Spreadsheet: 99cd6c62-c284-4ce4-8f36-58b0d4a29cf1
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Table S2: Selection of genes based on SNPs from lipid GWAS | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7
[NAME] and lead-SNPs used to select genes for RNAi screens. GWAS in italics appeared after start of the study. For 38 of the 56 loci all protein-coding genes within ±50kb of the respective lead SNPs were analyzed (locus in bold). The 18 remaining loci were represented by candidate genes close to the lead SNPs.
locus | lead SNP | location | nearest gene | traits | min p-value | references | genes selected
1p36.11 | rs12027135 | intron | TMEM57 | TC, LDL | 4e-11 | Teslovich 2010 | RHCE / TMEM57 / LDLRAP1
 | rs10903129 | intron | TMEM57 | TC | 5.4e-10 | [NAME] 2008
1p32.3 | [NAME] | coding | PCSK9 | LDL | 2e-44 | [NAME], Chasman 2009 | PCSK9
 | rs2479409 | intergenic | PCSK9 | LDL, TC | 2e-28 | Teslovich 2010
 | rs11206510 | intergenic | PCSK9 | LDL, CAD, MI | 3.5e-11 | [NAME], Willer 2008, [NAME], Waterworth 2010
1p31.3 | rs2131925 | intron | [NAME] | TG, [NAME], LDL | 9e-43 | Teslovich 2010 | DOCK7 / ANGPTL3 / ATG4C
 | rs1167998 | intron | [NAME] | TC, TG | 2e-12 | [NAME] 2008
 | rs10889353 | intron | [NAME] | TC, TG | 3.7e-12 | [NAME], Kathiresan 2009a
 | rs1748195 | intron | [NAME] | TG | 1.7e-10 | Willer 2008
 | rs12130333 | intergenic | [NAME] | TG | 2e-08 | [NAME] 2008
 | [NAME] | intron | [NAME] | TG | 6.4e-08 | Waterworth 2010
 | rs12042319 | intron | [NAME] | TG | 3.24e-07 | [NAME] 2008
1p13.3 | rs629301 | 3'UTR | CELSR2 | LDL, TC | 1e-170 | Teslovich 2010 | SARS / CELSR2 / PSRC1 / MYBPHL / SORT1
 | rs12740374 | 3'UTR | CELSR2 | LDL | 2e-42 | [NAME] 2009a
 | rs599839 | intergenic | [NAME] | LDL, CAD | 6.1e-33 | Willer 2008, [NAME] 2008, [NAME] 2007
 | rs646776 | intergenic | CELSR2 | TC, LDL, MI | 3e-29 | [NAME], [NAME] 2008, Sandhu 2008, Sabatti 2009, [NAME], Chasman 2009
 | rs660240 | 3'UTR | CELSR2 | LDL | 1.2e-26 | Waterworth 2010
 | rs4970834 | intron | CELSR2 | LDL | 3e-11 | Sandhu 2008
 | rs599839 | intergenic | [NAME] | CAD | 28900000000 | Schunkert 2011
1q24.2 | rs3917820 | intron | SELP | TG | 5.5e-06 | [NAME] 2008 | SELP / F5
1q32.1 | rs4844614 | intron | CR1L | LDL | 2.38e-07 | Sabatti 2009 | CR1L
1q41 | rs17465637 | intron | MIA3 | MI, CAD | 1.4e-09 | Samani 2007, [NAME], Schunkert 2011 | MIA3 / AIDA
1q42.13 | rs4846914 | intron | GALNT2 | HDL, TG | 4e-21 | [NAME], [NAME], Teslovich 2010 | GALNT2
 | rs2144300 | intron | GALNT2 | HDL, TG | 2.6e-14 | Willer 2008
 | rs10489615 | intron | GALNT2 | HDL | 3.8e-09 | Waterworth 2010
2p24.1 | rs1367117 | coding | APOB | LDL, TC | 4e-114 | Teslovich 2010, Chasman 2009 | APOB
 | rs1042034 | coding | APOB | TG, HDL | 1e-45 | Teslovich 2010
 | rs515135 | intergenic | APOB | LDL | 5e-29 | [NAME], Waterworth 2010
 | rs693 | coding | APOB | TC, LDL, TG | 8.7e-23 | [NAME] 2007, [NAME], [NAME] 2008, Sabatti 2009, Willer 2008, Sandhu 2008
 | rs562338 | intergenic | APOB | LDL, CAD | 5.6e-22 | Willer 2008, [NAME] 2008, Sandhu 2008
 | rs754523 | intergenic | AC010872.2 | LDL, CAD | 8.3e-12 | Willer 2008
 | rs7557067 | intergenic | APOB | TG | 9e-12 | [NAME] 2009a
 | rs1713222 | intergenic | APOB | LDL | 1e-08 | Sandhu 2008
 | rs673548 | intron | APOB | TG | 1.1e-08 | [NAME], Sabatti 2009
 | rs6754295 | intergenic | APOB | HDL, TG | 2.5e-08 | [NAME] 2008
 | rs6544366 | intergenic | APOB | TG | 1.9e-07 | Waterworth 2010
 | rs11902417 | intergenic | APOB | HDL | 3.7e-07 | Waterworth 2010
2p23.3 | rs1260326 | coding | GCKR | TG, [NAME], LDL | 6e-133 | [NAME], Sabatti 2009, Teslovich 2010, Chasman 2009 | GCKR
 | rs780094 | intron | GCKR | TG | 6.1e-32 | [NAME] 2007, [NAME] 2008, [NAME] 2008, Willer 2008, [NAME] 2008
 | rs1260333 | intergenic | GCKR | TG | 1.7e-19 | Waterworth 2010
 | rs11127129 | intron | RBKS | TG | 4.7e-07 | Willer 2008
2p21 | rs4299376 | intron | ABCG8 | LDL, TC | 2e-47 | Teslovich 2010 | ABCG5 / ABCG8
 | [NAME] | intron | ABCG8 | LDL | 2e-20 | [NAME] 2009a
 | rs6756629 | coding | ABCG5 | TC, LDL | 1.5e-11 | [NAME] 2008
 | rs11887534 | coding | ABCG5 | TG |  | Chasman 2009
2q33 | rs6725887 | intron | WDR12 | MI, CAD | 1.12e-09 | [NAME], Schunkert 2011 | ICA1L / WDR12 / ALS2CR8
3q13.3 | rs12695382 | intron | B4GALT4 | LDL, CAD | 1e-06 | Willer 2008 | B4GALT4 / UPK1B / ENSG00000251012
3q22.3 | rs9818870 | 3'UTR | [NAME] | CAD | 7.4e-13 | Erdmann 2009, Schunkert 2011 | [NAME]
5q13 | rs12916 | 3'UTR | HMGCR | TC, LDL | 9e-47 | Waterworth 2010, Teslovich 2010 | HMGCR
 | rs12654264 | intron | HMGCR | LDL | 1e-20 | [NAME] 2008
 | rs3846662 | intron | HMGCR | TC, LDL | 2.5e-19 | [NAME], Chasman 2009
 | [NAME] | intron | HMGCR | LDL | 8e-12 | [NAME], [NAME] 2008
5q21 | rs383830 | intergenic | FAM174A | CAD | 1.34e-05 | WTTC 2007 | FAM174A / ST8SI4
5q23 | rs6882076 | intergenic | TIMD4 | TC, LDL, TG | 7e-28 | Teslovich 2010 | TIMD4 / HAVCR1
 | rs1501908 | intergenic | TIMD4 | LDL | 1e-11 | [NAME] 2009a
6p24 | rs12526453 | intron | PHACTR1 | MI, CAD | 1.15e-09 | [NAME], Schunkert 2011 | PHACTR1
6p21.3 | rs2254287 | intron | COL11A2 | LDL, CAD | 5.1e-08 | Willer 2008 | B3GALT4
6q25 | rs6922269 | intron | MTHFD1L | CAD | 1.5e-05 | WTTC 2007, [NAME] 2007 | MTHFD1L
6q25.3 | rs1564348 | intron | SLC22A3 | LDL, TC | 2e-17 | Teslovich 2010 | SLC22A3 / LPAL2 / LPA / PLG
 | rs3798220 | coding | LPA | CAD | 3e-11 | Schunkert 2011
 | rs1084651 | intergenic | LPA | HDL | 3e-08 | Teslovich 2010
 | rs2048327 | intron | SLC22A3 | CAD | 4.34e-08 | Tregouet 2009
 | rs3127599 | intron | LPAL2 |  |  | Tregouet 2009
 | rs7767084 | intron | LPA |  |  | Tregouet 2009
 | rs10755578 | intron | LPA |  |  | Tregouet 2009
7p15.3 | rs12670798 | intron | DNAH11 | TC, LDL | 9e-10 | [NAME], Teslovich 2010 | DNAH11
7q11.23 | rs17145738 | intergenic | TBL2 | TG, HDL | 6e-58 | [NAME], Willer 2008, [NAME], Teslovich 2010 | FZD9 / BAZ1B / BCL7B / TBL2 / MLXIPL / VPS37D / DNAJC30 / WBSCR22
 | rs714052 | intron | BAZ1B | TG | 3e-15 | [NAME] 2009a
 | [NAME] | 3'UTR | BAZ1B | TG | 1.1e-12 | [NAME] 2008
 | rs1178979 | 3'UTR | BAZ1B | TG | 2.3e-12 | Waterworth 2010
 | rs3812316 | coding | MLXIPL | TG | 9.9e-08 | Kooner 2009
 | rs2074755 | intron | BAZ1B | TG | 3.51e-06 | [NAME] 2008
 | rs12056034 | intron | BAZ1B | TG | 0.0005 | Kooner 2009
 | rs799160 | intergenic | MLXIPL | TG | 0.04 | Kooner 2009
 | rs11974409 | intron | TBL2 | TG |  | Chasman 2009
8p23.1 | rs7819412 | intron | XKR6 | TG | 3e-08 | [NAME] 2009a | XKR6 / MTMR9 / AMAC1L2
8p21.3 | rs12678919 | intergenic | LPL | HDL, TG | 2e-115 | [NAME], Teslovich 2010 | LPL
 | rs328 | coding | LPL | HDL, TG | 2e-28 | [NAME], Saxena 2007, [NAME], Chasman 2009
 | rs10105606 | intergenic | LPL | TG | 3.6e-25 | Waterworth 2010
 | rs325 | intron | LPL | HDL, TG | 7.8e-25 | Kooner 2009, Waterworth 2010
 | rs10503669 | intergenic | LPL | HDL, TG | 3.9e-22 | Willer 2008
 | rs10096633 | intergenic | LPL | HDL, TG | 1.9e-18 | [NAME], Sabatti 2009
 | rs2083637 | intergenic | LPL | HDL, TG | 5.5e-18 | [NAME] 2008
 | rs17482753 | intergenic | LPL | TG | 5.2e-15 | [NAME] 2008, [NAME] 2008
 | rs2197089 | intergenic | LPL | HDL, TG | 1.1e-12 | Willer 2008
 | rs17411031 | intergenic | LPL | HDL | 1.3e-10 | [NAME] 2008
 | rs326 | intron | LPL | HDL, TG | 1.1e-08 | Kooner 2009
 | rs6586891 | intergenic | LPL | HDL, TG | 1.1e-06 | Willer 2008
 | rs331 | intron | LPL | HDL |  | Chasman 2009
8q24.13 | rs2954029 | intergenic | TRIB1 | TG, LDL | 3e-19 | [NAME], Waterworth 2010,Teslovich 2010 | TRIB1
 | rs17321515 | intergenic | TRIB1 | TG | 4e-17 | Willer 2008, [NAME] 2008
 | rs6987702 | intergenic | TRIB1 | TC | 3.3e-09 | [NAME] 2008
 | rs6982636 | intergenic | TRIB1 | TG |  | Chasman 2009
9p22.3 | [NAME] | intron | TTC39B | HDL, TC | 3e-12 | Teslovich 2010 | TTC39B
 | rs471364 | intron | TTC39B | HDL | 3e-10 | [NAME] 2009a
 | rs643531 | intron | TTC39B | HDL | 4.1e-08 | Waterworth 2010
9p21 | rs4977574 | intergenic | CDKN2B | MI, CAD | 2.7e-44 | [NAME], Schunkert 2011 | CDKN2A / CDKN2B / MTAP
 | rs1333049 | intergenic | CDKN2B | CAD | 1.16e-13 | WTTC 2007, [NAME] 2007
 | rs10757274 | intergenic | CDKN2B | MI, CAD |  | [NAME] 2007, [NAME] 2007
 | rs2383206 | intergenic | CDKN2B | MI, CAD |  | [NAME] 2007, [NAME] 2007
9q31.1 | rs1323432 | intron | GRIN3A | HDL | 0.00077 | Willer 2008 | GRIN3A / PPP3R2
9q31.1 | rs1883025 | intron | ABCA1 | HDL, TC | 2e-33 | [NAME], Teslovich 2010 | ABCA1
 | rs3905000 | intron | ABCA1 | HDL | 8.6e-13 | [NAME] 2008
 | [NAME] | intron | ABCA1 | HDL | 1.2e-10 | Willer 2008
 | rs3890182 | intron | ABCA1 | HDL | 3e-10 | [NAME], [NAME] 2008, Waterworth 2010
 | rs9282541 | coding | ABCA1 | HDL | 3.2e-05 | Kooner 2009
 | rs2515614 | intron | ABCA1 | HDL |  | Chasman 2009
10q11 | rs1746048 | intergenic | CXCL12 | MI, CAD | 2.93e-10 | [NAME], Schunkert 2011 | CXCL12
 | rs501120 | intergenic | CXCL12 | CAD | 9.46e-08 | Samani 2007
11p11.2 | rs7395662 | intergenic | OR4A47 | HDL | 6e-11 | [NAME] 2008 | FOLH1 / OR4A47
11p11.2 | [NAME] | intron | NR1H3 | HDL | 3.6e-08 | Sabatti 2009 | NR1H / MADD
 | rs2167079 | coding | ACP2 | HDL | 5.1e-08 | Sabatti 2009
11q12.2 | rs174546 | 3'UTR | FADS1 | LDL | 5e-24 | Sabatti 2009, Teslovich 2010 | FADS1 / FADS2 / FADS3
 | rs174547 | intron | FADS1 | HDL, TG | 2e-14 | [NAME] 2009a
 | rs174570 | intron | FADS2 | TC, LDL | 4.4e-13 | [NAME] 2008
 | rs174548 | intron | FADS1 | HDL, TG | 8.8e-11 | Waterworth 2010
 | rs102275 | intron | C11orf10 | LDL | 1.5e-07 | Sabatti 2009
 | rs174537 | intron | C11orf9 | LDL | 2.1e-07 | Sabatti 2009
 | rs174556 | intron | FADS1 | LDL | 3.5e-07 | Sabatti 2009
 | rs1535 | intron | FADS2 | LDL | 3.7e-07 | Sabatti 2009
11q23.3 | rs964184 | 3'UTR | ZNF259 | HDL, TG | 7e-240 | [NAME], Waterworth 2010, Teslovich 2010 | APOA1 / APOA4 / APOA5 / APOC3 / SIK3 / BUD13 / ZNF259
 | rs1558861 | intergenic | [NAME] | TG, LDL | 1.6e-23 | Kooner 2009, Waterworth 2010
 | rs12286037 | intron | ZNF259 | TG | 1e-26 | Willer 2008
 | rs4938303 | intergenic | [NAME] | TG | 4.1e-21 | Waterworth 2010
 | rs964184 | 3'UTR | ZNF259 | CAD | 1.02e-17 | Schunkert 2011
 | rs28927680 | 3'UTR | [NAME] | TG, HDL | 2e-17 | [NAME] 2008
 | [NAME] | intergenic | APOA5 | TG | 2.4e-15 | Willer 2008
 | rs12272004 | intergenic | [NAME] | TG | 5.4e-13 | [NAME] 2008
 | rs6589566 | intron | ZNF259 | TG | 3.7e-12 | [NAME] 2008
 | rs2000571 | intergenic | [NAME] | TG | 5.7e-08 | Willer 2008
 | rs486394 | intergenic | [NAME] | TG | 7.4e-06 | Willer 2008
 | rs2075292 | intron | SIK3 | TG | 3.7e-05 | Kooner 2009
 | rs7124741 | intron | SIK3 | TG | 0.0006 | Kooner 2009
 | rs17120139 | intron | SIK3 | TG | 0.0016 | Kooner 2009
 | rs3135506 | coding | APOA5 | TG |  | Chasman 2009
 | rs618923 | intron | ZNF259 | HDL |  | Chasman 2009
12q24.11 | rs7134594 | intron | MMAB | HDL | 7e-15 | Teslovich 2010 | MMAB / MVK
 | rs2338104 | intron | [NAME] | HDL | 1e-10 | [NAME], Willer 2008
 | rs9943753 | intron | MYO1H | HDL | 3.2e-06 | Waterworth 2010
12q24.31 | rs1169288 | coding | HNF1A | TC, LDL | 1e-14 | Teslovich 2010 | HNF1A / C12orf43 / OASL
 | [NAME] | intergenic | HNF1A | LDL | 2e-08 | [NAME] 2009a
 | rs2259816 | coding | HNF1A | CAD | 4.81e-07 | Erdmann 2009
 | rs1169300 | intron | HNF1A | LDL |  | Chasman 2009
15q22.1 | rs1532085 | intergenic | LIPC | HDL, TC, TG | 3e-96 | [NAME], Sabatti 2009, Teslovich 2010 | LIPC
 | rs10468017 | intergenic | LIPC | HDL | 8e-23 | [NAME] 2009a
 | rs261334 | intron CDH13 | LIPC | HDL | 4.9e-22 | Waterworth 2010
 | rs1800588 | intron | LIPC | HDL | 2e-20 | [NAME], Chasman 2009
 | rs4775041 | intergenic | LIPC | HDL, TG | 3.2e-20 | Willer 2008
 | [NAME] | intron | LIPC | HDL | 2.3e-15 | [NAME] 2008, [NAME] 2008
 | rs11858164 | intron | LIPC | HDL | 4.6e-05 | Kooner 2009
15q22 | rs17228212 | intron | SMAD3 | CAD | 1.98e-07 | Samani 2007 | SMAD3 / AAGAB
16q13 | [NAME] | intergenic | CETP | HDL, [NAME], LDL, TG | 7.0E-380 | Willer 2008, Sabatti 2009, Teslovich 2010 | CETP
 | rs1532624 | intron | CETP | HDL | 9.4e-94 | [NAME] 2008
 | rs173539 | intergenic | CETP | HDL | 4e-75 | [NAME] 2009a
 | rs1800775 | intergenic | CETP | HDL, TG | 1e-73 | [NAME], Chasman 2009
 | rs1864163 | intron | CETP | HDL | 6.9e-39 | Willer 2008
 | rs9989419 | intergenic | HERPUD1 | HDL | 1.3e-32 | Willer 2008, [NAME] 2008, Waterworth 2010
 | rs12596776 | intron | SLC12A3 | HDL | 2.8e-08 | Willer 2008
 | [NAME] | intron | NLRC5 | HDL | 3.3e-08 | Willer 2008
 | rs16965220 | intron | NLRC5 | TG | 9.6e-06 | Waterworth 2010
16q22.1 | rs16942887 | intron | PSKH1 | HDL | 8e-33 | Teslovich 2010 | CTCF / LCAT
 | rs2271293 | intron | NUTF2 | HDL | 8.3e-16 | [NAME], Kathiresan 2009a
 | rs255049 | intron | [NAME] | HDL | 3.06e-08 | Sabatti 2009
 | rs255052 | intron | DPEP2 | HDL | 1.2e-07 | Willer 2008
 | rs12449157 | 3'UTR | [NAME] | HDL | 2.3e-07 | Waterworth 2010
16q23 | rs8055236 | intron | CDH13 | CAD | 5.6e-06 | WTTC 2007 | CDH13
17p13.3 | rs9891572 | intergenic | METTL16 | HDL | 2.33e-07 | Sabatti 2009 | PAFAH1B1 / METTL16
18p11.2 | rs7229921 | intergenic | CIDEA | TG | 9.9e-06 | [NAME] 2008 | CIDEA
18q21 | rs7241918 | intergenic | [NAME] | HDL, TC | 3e-49 | Teslovich 2010 | [NAME], [NAME]
 | rs4939883 | intergenic | [NAME] | HDL | 7e-15 | [NAME], [NAME], Chasman 2009
 | rs2156552 | intergenic | [NAME] | HDL | 1.7e-12 | Willer 2008, [NAME], Waterworth 2010
19p13.2 | [NAME] | intron | ANGPTL4 | HDL | 3e-08 | Teslovich 2010 | ANGPTL4
 | rs2967605 | intergenic | RAB11B | HDL | 4e-08 | [NAME] 2009a
19p13.2 | rs6511720 | intron | LDLR | LDL, TC, CAD | 4e-117 | [NAME], [NAME], Willer 2008, Chasman 2009, Teslovich 2010 | LDLR / SMARCA4 / SPC24 / KANK2
 | rs2228671 | coding | LDLR | TC, LDL | 9.3e-24 | [NAME], Sandhu 2008
 | [NAME] | intron | SMARCA4 | MI, CAD | 9.7e-10 | [NAME], Schunkert 2011
 | rs11668477 | intergenic | LDLR | LDL | 1.5e-07 | Sabatti 2009, Sandhu 2008
 | rs688 | coding | LDLR | LDL | 7.3e-07 | [NAME] 2008
19p12 | rs10401969 | intron | SUGP1 | TC, TG, LDL | 3e-38 | [NAME], Waterworth 2010, Teslovich 2010 | ZNF101/ ZNF14 / NCAN / PBX4 / GATAD2A / HAPLN4 / MAU2 / NDUFA13 / SUGP1 / TM6SF2 / TSSK6 / YJEFN3 / CILP2 / LPAR2 / GMIP / ATP13A1
 | rs2304130 | intron | [NAME] | TC | 2e-15 | [NAME], Waterworth 2010
 | rs17216525 | intergenic | CILP2 | TG | 4e-11 | [NAME] 2009a
 | rs16996148 | intergenic | CILP2 | LDL, TG, CAD | 2.5e-09 | [NAME], Willer 2008
19q12 | rs7250581 | intergenic | POP4 | CAD | 2.5e-05 | WTTC 2007 | VSTMB2 / POP4
19q13.32 | rs4420638 | intergenic | APOC1 | LDL, TC, HDL, CAD | 9e-147 | [NAME] 2007, [NAME], [NAME], Sandhu 2008, [NAME] 2008, Willer 2008, [NAME], [NAME] 2008, Waterworth 2010 | APOE / APOC1 / APOC4 / APOC2 / TOMM40 / BCAM / BCL3 / CLPTM1 / CEACAM16 / CBLC / PVRL2 / RELB
 | rs439401 | intergenic | APOC1 | TG | 1e-30 | [NAME], Chasman 2009, Teslovich 2010
 | rs157580 | intron | TOMM40 | TC, LDL, TG | 2.1e-19 | [NAME], Sabatti 2009
 | rs2075650 | intron | TOMM40 | TC, LDL | 2.9e-19 | [NAME], Sandhu 2008
 | rs10402271 | intergenic | [NAME] | LDL, CAD | 1.2e-09 | Willer 2008, Sandhu 2008
 | rs4803750 | intergenic | BCL3 | LDL | 2.4e-08 | Sandhu 2008, Chasman 2009
 | rs4605275 | intergenic | PVRL2 |  | 4.7e-08 | Sandhu 2008
 | rs16979595 | intron | CLPTM1 | HDL | 5.8e-08 | [NAME] 2008
 | rs769449 | intron | APOE | HDL |  | Chasman 2009
20q12 | rs2902940 | intergenic | MAFB | TC, LDL | 6e-11 | Teslovich 2010 | MAFB
 | rs6102059 | intergenic | MAFB | LDL | 4e-09 | [NAME] 2009a
20q13.12 | rs1800961 | coding | HNF4A | HDL | 1e-15 | [NAME], Teslovich 2010 | HNF4A
20q13.12 | rs6065906 | intergenic | PCIF1 | HDL, TG | 2e-22 | Chasman 2009, Teslovich 2010 | PLTP
 | rs7679 | 3'UTR | PCIF1 | HDL, TG | 7e-11 | [NAME] 2009a
21q22 | rs9982601 | intergenic | [NAME] | MI, CAD | 6.4e-11 | [NAME], Schunkert 2011 | SLC5A3 / MRPS6 / KCNE2
22q12 | rs688034 | intron | SEZ6L | CAD | 3.8e-06 | WTTC 2007 | SEZ6L
X | rs5031002 | intron | AR | LDL | 2.37e-07 | Sabatti 2009 | AR