Spreadsheet: 3fbc7c08-0863-40c1-94a4-42bde9813cf7
Sheet: Sheet1

MedDRA (v12) Code | Code Desc | Preferred Desc | High Level Desc | Grade 1 | [NAME] | [NAME] | [NAME] | Grade 5
10000060 | A disorder characterized by swelling of the abdomen. | Abdominal distension |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; limiting instrumental ADL | Severe discomfort; limiting self care ADL | - | -
10000081 | A disorder characterized by a sensation of marked discomfort in the abdominal region. | Abdominal pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10000486 | A disorder characterized by abnormally high acidity (high hydrogen-ion concentration) of the blood and other body tissues. | Acidosis |  | pH <normal, but =>7.3 | - | pH <7.3 | Life-threatening consequences | Death
10000521 | A disorder characterized by involvement of the acoustic nerve (eighth cranial nerve). | Acoustic nerve disorder NOS |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10000636 | An abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment. | Activated partial thromboplastin time prolonged |  | >1 - 1.5 x ULN | >1.5 - 2.5 x ULN | >2.5 x ULN; hemorrhage | - | -
10001367 | A disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency. | Adrenal insufficiency |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; medical intervention indicated | Severe symptoms; hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death
10001409 | A disorder characterized by progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. | [NAME] respiratory distress syndrome |  | - | - | Present with radiologic findings; intubation not indicated | Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated | Death
10001497 | A disorder characterized by a state of restlessness associated with unpleasant feelings of irritability and tension. | Agitation |  | Mild mood alteration | Moderate mood alteration | Severe agitation; hospitalization not indicated | Life-threatening consequences; urgent intervention indicated | Death
10001540 | A disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs. | Akathisia |  | Mild restlessness or increased motor activity | Moderate restlessness or increased motor activity; limiting instrumental ADL | Severe restlessness or increased motor activity; limiting self care ADL | - | -
10001551 | A finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen. | Alanine aminotransferase increased |  | >ULN - 3.0 x ULN | Asymptomatic with ALT >3.0 - 5.0 x ULN;  >3 x ULN with the appearance of worsening of fatigue, nausea, vomiting, right upper quadrant pain or tenderness, fever, rash, or eosinophilia | >5.0 - 20.0 x ULN;  >5 x ULN for >2 weeks | >20.0 x ULN | -
10001598 | A disorder characterized by an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches. | Alcohol intolerance |  | - | Present | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10001675 | A finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen. | Alkaline phosphatase increased |  | >ULN - 2.5 x ULN | >2.5 - 5.0 x ULN | >5.0 - 20.0 x ULN | >20.0 x ULN | -
10001680 | A disorder characterized by abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues. | Alkalosis |  | pH >normal, but <=7.5 |  | pH >7.5 | Life-threatening consequences | Death
10001718 | A disorder characterized by an adverse local or general response from exposure to an allergen. | Allergic reaction |  | Transient flushing or rash, drug fever <38 degrees C (<100.4 degrees F); intervention not indicated | Intervention or infusion interruption indicated; responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics); prophylactic medications indicated for <=24 hrs | Prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates) | Life-threatening consequences; urgent intervention indicated | Death
10001723 | A disorder characterized by an inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea and itching. | Allergic rhinitis |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | - | - | -
10001760 | A disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location. | Alopecia |  | Hair loss of up to 50% of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but it does not require a wig or hair piece to camouflage | Hair loss of >50% normal for that individual that is readily apparent to others; a wig or hair piece is necessary if the patient desires to completely camouflage the hair loss; associated with psychosocial impact | - | - | -
10001949 | A disorder characterized by systematic and extensive loss of memory. | Amnesia |  | Mild; transient memory loss | Moderate; short term memory loss; limiting instrumental ADL | Severe; long term memory loss; limiting self care ADL | - | -
10002156 | A disorder characterized by an abnormal communication between the opening in the anal canal to the perianal skin. | Anal fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding, [NAME] or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10002167 | A disorder characterized by a sensation of marked discomfort in the anal region. | Anal pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10002176 | A disorder characterized by a narrowing of the lumen of the anal canal. | Anal stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Symptomatic and severely altered GI function; non-emergent operative intervention indicated; [NAME] or hospitalization indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10002180 | A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the anal canal. | Anal ulcer |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10002218 | A disorder characterized by an acute inflammatory reaction resulting from the release of histamine and histamine-like substances from mast cells, causing a hypersensitivity immune response. Clinically, it presents with breathing difficulty, dizziness, hypotension, cyanosis and loss of consciousness and may lead to death. | Anaphylaxis |  | - | - | Symptomatic bronchospasm, with or without urticaria; parenteral intervention indicated; allergy-related edema/angioedema; hypotension | Life-threatening consequences; urgent intervention indicated | Death
10002272 | A disorder characterized by an reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability. | Anemia |  | Hemoglobin (Hgb) <LLN - 10.0 g/dL; <LLN - 6.2 mmol/L; <LLN - 100 g/L | Hgb <10.0 - 8.0 g/dL; <6.2 - 4.9 mmol/L;  <100 - 80g/L | Hgb <8.0 - 6.5 g/dL; <4.9 - 4.0 mmol/L; <80 - 65 g/L; transfusion indicated | Life-threatening consequences; urgent intervention indicated | Death
10002544 | A finding of damage to the ankle joint characterized by a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot. | Ankle fracture |  | Mild; non-surgical intervention indicated | Limiting instrumental ADL; operative intervention indicated | Limiting self care ADL; elective surgery indicated | - | -
10002646 | A disorder characterized by a loss of appetite. | Anorexia |  | Loss of appetite without alteration in eating habits | Oral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated | Associated with significant weight loss or malnutrition (e.g., inadequate oral [NAME] intake); tube feeding or TPN indicated | Life-threatening consequences; urgent intervention indicated | Death
10002652 | A disorder characterized by an inability to achieve orgasm. | Anorgasmia |  | Inability to achieve orgasm not adversely affecting relationship | Inability to achieve orgasm adversely affecting relationship | - | - | -
10002855 | A disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus. | Anxiety |  | Mild symptoms; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL; hospitalization not indicated | Life-threatening; hospitalization indicated | Death
10002899 | A finding of damage to the aorta. | Aortic injury |  | - | - | Severe symptoms; limiting self care ADL; disabling; repair or revision indicated | Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated | Death
10002953 | A disorder characterized by the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic). | Aphonia |  | - | - | Voicelessness; unable to speak | - | -
10002972 | A disorder characterized by cessation of breathing. | Apnea |  | - | - | Present; medical intervention indicated | Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated | Death
10003011 | A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent. | Appendicitis |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10003012 | A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity. | Appendicitis perforated |  | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10003074 | A disorder characterized by inflammation of the arachnoid membrane and adjacent subarachnoid space. | Arachnoiditis |  | Mild symptoms | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10003162 | A finding of damage to an artery. | Arterial injury |  | Asymptomatic diagnostic finding; intervention not indicated | Symptomatic (e.g., claudication); repair or revision not indicated | Severe symptoms; limiting self care ADL; disabling; repair or revision indicated | Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated | Death
10003239 | A disorder characterized by a sensation of marked discomfort in a joint. | Arthralgia |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10003246 | A disorder characterized by inflammation involving a joint. | Arthritis |  | Mild pain with inflammation, erythema, or joint swelling | Moderate pain associated with signs of inflammation, erythema, or joint swelling; limiting instrumental ADL | Severe pain associated with signs of inflammation, erythema, or joint swelling; irreversible joint damage; disabling; limiting self care ADL | - | -
10003445 | A disorder characterized by accumulation of serous or hemorrhagic fluid in the peritoneal cavity. | Ascites |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; invasive intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10003481 | A finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen. | Aspartate aminotransferase increased |  | >ULN - 3.0 x ULN | Asymptomatic with AST >3.0 - 5.0 x ULN; >3 x ULN with the appearance of worsening of fatigue, nausea, vomiting, right upper quadrant pain or tenderness, fever, rash, or eosinophilia | >5.0 - 20.0 x ULN;  >5 x ULN for >2 weeks | >20.0 x ULN | -
10003504 | A disorder characterized by inhalation of solids or liquids into the lungs. | Aspiration |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Altered eating habits; coughing or choking episodes after eating or swallowing; medical intervention indicated (e.g., suction or oxygen) | Dyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally | Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated | Death
10003586 | A disorder characterized by a dysrhythmia without cardiac electrical activity. Typically, this is accompanied by cessation of the pumping function of the heart. | Asystole |  | Periods of asystole; non-urgent medical management indicated | - | - | Life-threatening consequences; urgent intervention indicated | Death
10003591 | A disorder characterized by lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities. | [NAME] |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL; mechanical assistance indicated | - | -
10003598 | A disorder characterized by the collapse of part or the entire lung. | Atelectasis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic (e.g., dyspnea, cough); medical intervention indicated (e.g., chest physiotherapy, suctioning); bronchoscopic suctioning | Oxygen indicated; hospitalization or elective operative intervention indicated (e.g., stent, laser) | Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated | Death
10003658 | A disorder characterized by a dysrhythmia without discernible P waves and an irregular ventricular response due to multiple reentry circuits. The rhythm disturbance originates above the ventricles. | Atrial fibrillation |  | Asymptomatic, intervention not indicated | Non-urgent medical intervention indicated | Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation | Life-threatening consequences; urgent intervention indicated | Death
10003662 | A disorder characterized by a dysrhythmia with organized rhythmic atrial contractions with a rate of 200-300 beats per minute. The rhythm disturbance originates in the atria. | Atrial flutter |  | Asymptomatic, intervention not indicated | Non-urgent medical intervention indicated | Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation | Life-threatening consequences; urgent intervention indicated | Death
10003673 | A disorder characterized by a dysrhythmia with complete failure of atrial electrical impulse conduction through the AV node to the ventricles. | Atrioventricular block complete |  |  | Non-urgent intervention indicated | Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) | Life-threatening consequences; urgent intervention indicated | Death
10003674 | A disorder characterized by a dysrhythmia with a delay in the time required for the conduction of an electrical impulse through the atrioventricular (AV) node beyond 0.2 seconds; prolongation of the PR interval greater than 200 milliseconds. | Atrioventricular block first degree |  | Asymptomatic, intervention not indicated | Non-urgent intervention indicated | -
10003883 | A disorder characterized by laboratory test results that indicate complete absence of spermatozoa in the semen. | Azoospermia |  | - | - | Absence of sperm in ejaculate | - | -
10003988 | A disorder characterized by marked discomfort sensation in the back region. | Back pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10004665 | A disorder characterized by an abnormal communication between the bile ducts and another organ or anatomic site. | Biliary fistula |  | - | Symptomatic and intervention not indicated | Severely altered GI function; TPN indicated; endoscopic intervention indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10005047 | A disorder characterized by an infectious process involving the bladder. | Bladder infection |  | - | Oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10005265 | A disorder characterized by subject-reported feeling of uncomfortable fullness of the abdomen. | Bloating |  | No change in bowel function or oral intake | Symptomatic, decreased oral intake; change in bowel function | - | - | -
10005329 |  | Blood and lymphatic system disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10005332 | A finding based on laboratory test results that indicate abnormal levels of antidiuretic hormone in the blood specimen. | Blood antidiuretic hormone abnormal |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Hospitalization indicated | - | -
10005364 | A finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice. | Blood bilirubin increased |  | >ULN - 1.5 x ULN | >1.5 - 3.0 x ULN | >3.0 - 10.0 x ULN | >10.0 x ULN | -
10005452 | A finding based on laboratory test results that indicate an decrease in levels of corticotrophin in a blood specimen. | Blood corticotrophin decreased |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Hospitalization indicated | - | -
10005561 | A finding based on laboratory test results that indicate abnormal levels of gonadotrophin hormone in a blood specimen. | Blood gonadotrophin abnormal |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10005778 | A finding based on laboratory test results that indicate abnormal levels of prolactin hormone in a blood specimen. | Blood prolactin abnormal |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | - | - | -
10005886 | A disorder characterized by visual perception of unclear or fuzzy images. | Blurred vision |  | Intervention not indicated | Symptomatic; limiting instrumental ADL | Limiting self care ADL | - | -
10005901 | A disorder characterized by an abnormal body smell resulting from the growth of bacteria on the body. | Body odor |  | Mild odor; physician intervention not indicated; self care interventions | Pronounced odor; psychosocial impact; patient seeks medical intervention | - | - | -
10006002 | A disorder characterized by marked discomfort sensation in the bones. | Bone pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10006179 | A disorder characterized by underdevelopment of the breast. | Breast atrophy |  | Minimal asymmetry; minimal atrophy | Moderate asymmetry; moderate atrophy | Asymmetry >1/3 of breast volume; severe atrophy | - | -
10006259 | A disorder characterized by an infectious process involving the breast. | Breast infection |  | - | Local infection with moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | Severe infection; axillary adenitis;  IV antibacterial, antifungal, or antiviral intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10006298 | A disorder characterized by marked discomfort sensation in the breast region. | Breast pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10006437 | A disorder characterized by an abnormal communication between the bronchus and another organ or anatomic site. | Bronchial fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) | Life-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated | Death
10006440 | A disorder characterized by blockage of a bronchus passage, most often by bronchial secretions and exudates. | Bronchial obstruction |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic (e.g., mild wheezing); endoscopic evaluation indicated; radiographic evidence of atelectasis/lobar collapse; medical management indicated (e.g., steroids, bronchodilators) | Shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement) | Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated | Death
10006482 | A disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall. | Bronchospasm |  | Mild symptoms; intervention not indicated | Symptomatic; medical intervention indicated; limiting instrumental ADL | Limiting self care ADL; oxygen saturation decreased | Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated | Death
10006504 | A finding of injury of the soft tissues or bone characterized by leakage of blood into surrounding tissues. | Bruising |  | Localized or in a dependent area | Generalized | - | - | -
10006556 | A disorder characterized by inflammation of the skin characterized by the presence of bullae which are filled with fluid. | Bullous dermatitis |  | Asymptomatic; blisters covering <10% BSA | Blisters covering 10 - 30% BSA; painful blisters; limiting instrumental ADL | Blisters covering >30% BSA; limiting self care ADL | Blisters covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated | Death
10006634 | A finding of impaired integrity to the anatomic site of an adverse thermal reaction. Burns can be caused by exposure to chemicals, direct heat, electricity, flames and radiation. The extent of damage depends on the length and intensity of exposure and time until provision of treatment. | Burn |  | Minimal symptoms; intervention not indicated | Medical intervention; minimal debridement indicated | Moderate to major debridement or reconstruction indicated | Life-threatening consequences | Death
10007196 | A disorder characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning.  It can lead to generalized edema and multiple organ failure. | Capillary leak syndrome |  | - | Symptomatic; medical intervention indicated | Severe symptoms; intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10007515 | A disorder characterized by cessation of the pumping function of the heart. | Cardiac arrest |  | - | - | - | Life-threatening consequences; urgent intervention indicated | Death
10007541 |  | Cardiac disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10007612 | A laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen. | Cardiac troponin I increased |  | Levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer | - | Levels consistent with myocardial infarction as defined by the manufacturer | - | -
10007613 | A laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen. | Cardiac troponin T increased |  | Levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer | - | Levels consistent with myocardial infarction as defined by the manufacturer | - | -
10007739 | A disorder characterized by partial or complete opacity of the crystalline lens of one or both eyes. This results in a decrease in visual acuity and eventual blindness if untreated. | Cataract |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; moderate decrease in visual acuity (20/40 or better) | Symptomatic with marked decrease in visual acuity (worse than 20/40 but better than 20/200); operative intervention indicated (e.g., cataract surgery) | Blindness (20/200 or worse) in the affected eye | -
10007810 | A disorder characterized by an infectious process that arises secondary to catheter use. | Catheter related infection |  | - | Localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10007839 | A finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen. | CD4 lymphocytes decreased |  | <LLN - 500/mm3;  <LLN - 0.5 x 10e9 /L | <500 - 200/mm3; <0.5 - 0.2 x 10e9 /L | <200 - 50/mm3; <0.2 x 0.05 - 10e9 /L | <50/mm3; <0.05 x 10e9 /L | -
10008164 | A disorder characterized by loss of cerebrospinal fluid into the surrounding tissues. | Cerebrospinal fluid leakage |  | Post-craniotomy: asymptomatic; Post-lumbar puncture: transient headache; postural care indicated | Post-craniotomy: moderate symptoms; medical intervention indicated; Post-lumbar puncture: persistent moderate symptoms; blood patch indicated | Severe symptoms; medical intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10008330 | A disorder characterized by an infectious process involving the uterine cervix. | Cervicitis infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10008417 | A disorder characterized by inflammation of the lip. | Cheilitis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL; intervention indicated | - | -
10008481 | A disorder characterized by substernal discomfort due to insufficient myocardial oxygenation. | Chest pain - cardiac |  | Mild pain | Moderate pain; limiting instrumental ADL | Pain at rest; limiting self care ADL | - | -
10008496 | A disorder characterized by marked discomfort sensation in the chest wall region. | Chest wall pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10008531 | A disorder characterized by a sensation of cold that often marks a physiologic response to sweating after a fever. | Chills |  | Mild sensation of cold; shivering; chattering of teeth | Moderate tremor of the entire body; narcotics indicated | Severe or prolonged, not responsive to narcotics | - | -
10008612 | A disorder characterized by inflammation involving the gallbladder. It may be associated with the presence of gallstones. | Cholecystitis |  | - | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10008661 | A finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen. | Cholesterol high |  | >ULN - 300 mg/dL; >ULN - 7.75 mmol/L | >300 - 400 mg/dL; >7.75 - 10.34 mmol/L | >400 - 500 mg/dL; >10.34 - 12.92 mmol/L | >500 mg/dL; >12.92 mmol/L | -
10009845 | A disorder characterized by a conspicuous change in cognitive function. | Cognitive disturbance |  | Mild cognitive disability; not interfering with work/school/life performance; specialized educational services/devices not indicated | Moderate cognitive disability; interfering with work/school/life performance but capable of independent living; specialized resources on part time basis indicated | Severe cognitive disability; significant impairment of work/school/life performance | - | -
10009887 | A disorder characterized by inflammation of the colon. | Colitis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Abdominal pain; mucus or blood in stool | Severe abdominal pain; change in bowel habits; medical intervention indicated; peritoneal signs | Life-threatening consequences; urgent intervention indicated | Death
10009995 | A disorder characterized by an abnormal communication between the large intestine and another organ or anatomic site. | Colonic fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; bowel rest, [NAME] or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10009998 | A disorder characterized by bleeding from the colon. | Colonic hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10010000 | A disorder characterized by blockage of the normal flow of the intestinal contents in the colon. | Colonic obstruction |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Hospitalization indicated; elective operative intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10010001 | A disorder characterized by a rupture in the colonic wall. | Colonic perforation |  |  | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10010004 | A disorder characterized by a narrowing of the lumen of the colon. | Colonic stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10010006 | A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the colon. | Colonic ulcer |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10010250 | A disorder characterized by a deterioration in the ability to concentrate. | Concentration impairment |  | Mild inattention or decreased level of concentration | Moderate impairment in attention or decreased level of concentration; limiting instrumental ADL | Severe impairment in attention or decreased level of concentration; limiting self care ADL | - | -
10010276 | A disorder characterized by pathological irregularities in the cardiac conduction system. | Conduction disorder |  | Mild symptoms; intervention not indicated | Moderate symptoms | Severe symptoms; intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10010300 | A disorder characterized by a lack of clear and orderly thought and behavior. | Confusion |  | Mild disorientation | Moderate disorientation; limiting instrumental ADL | Severe disorientation; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10010331 |  | Congenital, familial and genetic disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10010741 | A disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye. | Conjunctivitis |  | Asymptomatic or mild symptoms; intervention not indicated | Symptomatic; topical intervention indicated (e.g., antibiotics); limiting instrumental ADL | Limiting self care ADL | - | -
10010742 | A disorder characterized by an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes. | Conjunctivitis infective |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10010774 | A disorder characterized by irregular and infrequent or difficult evacuation of the bowels. | Constipation |  | Occasional or intermittent symptoms; occasional use of stool softeners, laxatives, dietary modification, or enema | Persistent symptoms with regular use of laxatives or enemas; limiting instrumental ADL | Obstipation with manual evacuation indicated; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10010783 | A disorder characterized by a thickened and fibrotic pericardial sac; these fibrotic changes impede normal myocardial function by restricting myocardial muscle action. | Constrictive pericarditis |  | - | - | Symptomatic heart failure or other cardiac symptoms, responsive to intervention | Refractory heart failure or other poorly controlled cardiac symptoms | Death
10011224 | A disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound. | Cough |  | Mild symptoms; nonprescription intervention indicated | Moderate symptoms, medical intervention indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10011268 | A finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen. | CPK increased |  | >ULN - 2.5 x ULN | >2.5 x ULN - 5 x ULN | >5 x ULN - 10 x ULN | >10 x ULN | -
10011368 | A finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen. | Creatinine increased |  | >1 - 1.5 x baseline; >ULN - 1.5 x ULN | >1.5 - 3.0 x baseline; >1.5 - 3.0 x ULN | >3.0 baseline; >3.0 - 6.0 x ULN | >6.0 x ULN | -
10011655 | A disorder characterized by signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids. | Cushingoid |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | Severe symptoms, medical intervention or hospitalization indicated | - | -
10011912 | A disorder characterized by cessation of life occurring during the first 28 days of life. | Death neonatal |  | - | - | - | - | Death
10011914 | A cessation of life that cannot be attributed to a CTCAE term associated with Grade 5. | Death NOS |  | - | - | - | - | Death
10012174 | A disorder characterized by excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis. | Dehydration |  | Increased oral fluids indicated; dry mucous membranes; diminished skin turgor | IV fluids indicated <24 hrs | IV fluids or hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death
10012205 | A disorder characterized by unusually late sexual maturity. | Delayed puberty |  | - | No breast development by age 13 yrs for females; testes volume of <3 cc or no Tanner Stage 2 development by age 14.5 yrs for males | No breast development by age 14 yrs for females; no increase in testes volume or no Tanner Stage 2 by age 16 yrs for males; hormone replacement indicated | - | -
10012218 | A disorder characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Usually, it is a reversible condition. | Delirium |  | Mild acute confusional state | Moderate and acute confusional state; limiting instrumental ADL | Severe and acute confusional state; limiting self care ADL; hospitalization indicated | Life-threatening consequences,  threats of harm to self or others; hospitalization indicated | Death
10012260 | A disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense. | Delusions |  | - | Moderate delusional symptoms | Severe delusional symptoms; hospitalization not indicated | Life-threatening consequences,  threats of harm to self or others; hospitalization indicated | Death
10012318 | A disorder characterized by the decay of a tooth, in which it becomes softened, discolored and/or porous. | Dental caries |  | One or more dental caries, not involving the root | Dental caries involving the root | Dental caries resulting in pulpitis or periapical abscess or resulting in tooth loss | - | -
10012373 | A disorder characterized by a decrease in ability to perceive and respond. | Depressed level of consciousness |  | Decreased level of alertness | Sedation; slow response to stimuli; limiting instrumental ADL | Difficult to arouse | Life-threatening consequences | Death
10012378 | A disorder characterized by melancholic feelings of grief or unhappiness. | Depression |  | Mild depressive symptoms | Moderate depressive symptoms; limiting instrumental ADL | Severe depressive symptoms; limiting self care ADL; hospitalization not indicated | Life-threatening consequences,  threats of harm to self or others; hospitalization indicated | Death
10012727 | A disorder characterized by frequent and watery bowel movements. | Diarrhea |  | Increase of <4 stools per day over baseline; mild increase in ostomy output compared to baseline | Increase of 4 - 6 stools per day over baseline; moderate increase in ostomy output compared to baseline | Increase of >=7 stools per day over baseline; incontinence; hospitalization indicated; severe increase in ostomy output compared to baseline; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10013442 | A disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors. | Disseminated intravascular coagulation |  | - | Laboratory findings with no bleeding | Laboratory findings and bleeding | Life-threatening consequences; urgent intervention indicated | Death
10013573 | A disorder characterized by a disturbing sensation of lightheadedness, unsteadiness, giddiness, spinning or rocking. | Dizziness |  | Mild unsteadiness or sensation of movement | Moderate unsteadiness or sensation of movement; limiting instrumental ADL | Severe unsteadiness or sensation of movement; limiting self care ADL | - | -
10013774 | A disorder characterized by dryness of the cornea and conjunctiva. | Dry eye |  | Asymptomatic; clinical or diagnostic observations only; mild symptoms relieved by lubricants | Symptomatic; multiple agents indicated; limiting instrumental ADL | Decrease in visual acuity (<20/40); limiting self care ADL | - | -
10013781 | A disorder characterized by reduced salivary flow in the oral cavity. | Dry mouth |  | Symptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow >0.2 ml/min | Moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min | Inability to adequately aliment orally; tube feeding or TPN indicated; unstimulated saliva <0.1 ml/min | - | -
10013786 | A disorder characterized by flaky and dull skin; the pores are generally fine, the texture is a papery thin texture. | Dry skin |  | Covering <10% BSA and no associated erythema or pruritus | Covering 10 - 30% BSA and associated with erythema or pruritus; limiting instrumental ADL | Covering >30% BSA and associated with pruritus; limiting self care ADL | - | -
10013828 | A disorder characterized by an abnormal communication between the duodenum and another organ or anatomic site. | Duodenal fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding, [NAME] or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10013830 | A disorder characterized by blockage of the normal flow of stomach contents through the duodenum. | Duodenal obstruction |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Hospitalization or elective operative intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10013832 | A disorder characterized by a rupture in the duodenal wall. | Duodenal perforation |  | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10013836 | A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the duodenal wall. | Duodenal ulcer |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; medical intervention indicated; limiting instrumental ADL | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10013887 | A disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech. | Dysarthria |  | Mild slurred speech | Moderate impairment of articulation or slurred speech | Severe impairment of articulation or slurred speech | - | -
10013911 | A disorder characterized by abnormal sensual experience with the taste of foodstuffs; it can be related to a decrease in the sense of smell. | [NAME] |  | Altered taste but no change in diet | Altered taste with change in diet (e.g., oral supplements); noxious or unpleasant taste; loss of taste | - | - | -
10013934 | A disorder characterized by abnormally painful abdominal cramps during menses. | [NAME] |  | Mild symptoms; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10013941 | A disorder characterized by painful or difficult coitus. | Dyspareunia |  | Mild discomfort or pain associated with vaginal penetration; discomfort relieved with use of vaginal lubricants or estrogen | Moderate discomfort or pain associated with vaginal penetration; discomfort or pain partially relieved with use of vaginal lubricants or estrogen | Severe discomfort or pain associated with vaginal penetration; discomfort or pain unrelieved by vaginal lubricants or estrogen | - | -
10013946 | A disorder characterized by an uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach, bloating, heartburn, nausea and vomiting. | Dyspepsia |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | Severe symptoms; surgical intervention indicated
10013950 | A disorder characterized by difficulty in swallowing. | Dysphagia |  | Symptomatic, able to eat regular diet | Symptomatic and altered eating/swallowing | Severely altered eating/swallowing; tube feeding or [NAME] or hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death
10013951 | A disorder characterized by impairment of verbal communication skills, often resulting from brain damage. | Dysphasia |  | Awareness of receptive or expressive characteristics; not impairing ability to communicate | Moderate receptive or expressive characteristics; impairing ability to communicate spontaneously | Severe receptive or expressive characteristics; impairing ability to read, write or communicate intelligibly | - | -
10013963 | A disorder characterized by an uncomfortable sensation of difficulty breathing. | Dyspnea |  | Shortness of breath with moderate exertion | Shortness of breath with minimal exertion; limiting instrumental ADL | Shortness of breath at rest; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10013993 |  | Ear and labyrinth disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10014020 | A disorder characterized by a sensation of marked discomfort in the ear. | Ear pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10014217 | A disorder characterized by swelling due to an excessive accumulation of fluid in the brain. | Edema cerebral |  | - | - | - | Life-threatening consequences; urgent intervention indicated
10014222 | A disorder characterized by swelling due to excessive fluid accumulation in facial tissues. | Edema face |  | Localized facial edema | Moderate localized facial edema; limiting instrumental ADL | Severe swelling; limiting self care ADL | - | -
10014326 | A disorder characterized by problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation. | Ejaculation disorder |  | Diminished ejaculation | Anejaculation or retrograde ejaculation |  | - | -
10014383 | A finding of a cardiac dysrhythmia characterized by an abnormally long corrected QT interval. | [NAME] corrected interval prolonged |  | [NAME] ms | QTc 481 - 500 ms | QTc >= 501 ms on at least two separate ECGs | QTc >= 501 or >60 ms change from baseline and [NAME] or polymorphic ventricular tachycardia or signs/symptoms of serious arrhythmia | -
10014594 | A disorder characterized by an infectious process involving the brain tissue. | Encephalitis infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; severe changes in mental status; self-limited seizure activity; focal neurologic abnormalities | Life-threatening consequences; urgent intervention indicated | Death
10014621 | A disorder characterized by an infectious process involving the brain and spinal cord tissues. | Encephalomyelitis infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10014625 | A disorder characterized by a pathologic process involving the brain. | Encephalopathy |  | Mild symptoms | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10014678 | A disorder characterized by an infectious process involving the endocardial layer of the heart. | Endocarditis infective |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10014698 |  | Endocrine disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10014801 | A disorder characterized by an infectious process involving the internal structures of the eye. | Endophthalmitis |  | - | Local intervention indicated | Systemic intervention or hospitalization indicated | Blindness (20/200 or worse) | -
10014893 | A disorder characterized by inflammation of the small and large intestines. | Enterocolitis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Abdominal pain; mucus or blood in stool | Severe or persistent abdominal pain; fever; ileus; peritoneal signs | Life-threatening consequences; urgent intervention indicated | Death
10015090 | A disorder characterized by bleeding from the nose. | Epistaxis |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated (e.g., [NAME], cauterization; topical vasoconstrictors) | Transfusion, radiologic, endoscopic, or operative intervention indicated (e.g., hemostasis of bleeding site) | Life-threatening consequences; urgent intervention indicated | Death
10015218 | A disorder characterized by target lesions (a pink-red ring around a pale center). | Erythema multiforme |  | Target lesions covering <10% BSA and not associated with skin tenderness | Target lesions covering 10 - 30% BSA and associated with skin tenderness | Target lesions covering >30% BSA and associated with oral or genital erosions | Target lesions covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated | Death
10015277 | A disorder characterized by generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area. | Erythroderma |  | - | Erythema covering >90% BSA without associated symptoms; limiting instrumental ADL | Erythema covering >90% BSA with associated symptoms (e.g., pruritus or tenderness); limiting self care ADL | Erythema covering >90% BSA with associated fluid or electrolyte abnormalities; ICU care or burn unit indicated | Death
10015384 | A disorder characterized by bleeding from the esophagus. | Esophageal hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10015387 | A disorder characterized by blockage of the normal flow of the contents in the esophagus. | Esophageal obstruction |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Hospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent intervention indicated | Death
10015388 | A disorder characterized by a sensation of marked discomfort in the esophageal region. | Esophageal pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10015448 | A disorder characterized by a narrowing of the lumen of the esophagus. | Esophageal stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10015451 | A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the esophageal wall. | Esophageal ulcer |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10015453 | A disorder characterized by bleeding from esophageal varices. | Esophageal varices hemorrhage |  |  | Self-limited; intervention not indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10015461 | A disorder characterized by inflammation of the esophageal wall. | Esophagitis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered eating/swallowing;  oral supplements indicated | Severely altered eating/swallowing; tube feeding, [NAME] or hospitalization indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10015533 | A disorder characterized by an exaggerated feeling of well-being which is disproportionate to events and stimuli. | Euphoria |  | Mild mood elevation | Moderate mood elevation | Severe mood elevation (e.g., [NAME]) | - | -
10015688 | A disorder characterized by non-neoplastic overgrowth of bone. | Exostosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; limiting instrumental ADL | Severe symptoms; limiting self care ADL; elective operative intervention indicated | - | -
10015829 | A disorder characterized by incomplete paralysis of an extraocular muscle. | Extraocular muscle paresis |  | Asymptomatic; clinical or diagnostic observations only | Symptomatic; limiting instrumental ADL | Limiting self care ADL; disabling | - | -
10015832 | A disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness. | Extrapyramidal disorder |  | Mild involuntary movements | Moderate involuntary movements; limiting instrumental ADL | Severe involuntary movements or torticollis; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10015919 |  | Eye disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately sight-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Sight-threatening consequences; urgent intervention indicated; blindness (20/200 or worse) in the affected eye | -
10015929 | A disorder characterized by an infectious process involving the eye. | Eye infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated; enucleation | Death
10015958 | A disorder characterized by a sensation of marked discomfort in the eye. | Eye pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10016059 | A disorder characterized by a sensation of marked discomfort in the face. | Facial pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10016173 | A finding of sudden movement downward, usually resulting in injury. | Fall |  | Minor with no resultant injuries; intervention not indicated | Symptomatic; noninvasive intervention indicated | Hospitalization indicated | - | -
10016241 | A disorder characterized by shrinking of adipose tissue. | Fat atrophy |  | Covering <10% BSA and asymptomatic | Covering 10 - 30% BSA and associated with erythema or tenderness; limiting instrumental ADL | Covering >30% BSA; associated with erythema or tenderness; limiting self-care ADL | - | -
10016256 | A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities. | Fatigue |  | Fatigue relieved by rest | Fatigue not relieved by rest; limiting instrumental ADL | Fatigue not relieved by rest, limiting self care ADL | - | -
10016288 | A disorder characterized by a decrease in neutrophils associated with fever. | Febrile neutropenia |  | - | - | Present | Life-threatening consequences; urgent intervention indicated | Death
10016296 | A disorder characterized by inability to control the escape of stool from the rectum. | Fecal incontinence |  | Occasional use of pads required | Daily use of pads required | Severe symptoms; elective operative intervention indicated | - | -
10016479 | A disorder characterized by death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation. | Fetal death |  | - | - | - | - | Fetal loss at any gestational age
10016558 | A disorder characterized by elevation of the body's temperature above the upper limit of normal. | Fever |  | 38.0 - 39.0 degrees C  (100.4 - 102.2 degrees F) | >39.0 - 40.0 degrees C (102.3 - 104.0 degrees F) | >40.0 degrees C (>104.0 degrees F) for <=24 hrs | >40.0 degrees C (>104.0 degrees F) for >24 hrs | Death
10016596 | A finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen. | Fibrinogen decreased |  | <1.0 - 0.75 x LLN  or <25% decrease from baseline | <0.75 - 0.5 x LLN or 25 - <50% decrease from baseline | <0.5 - 0.25 x LLN or 50 - <75% decrease from baseline | <0.25 x LLN  or 75% decrease from baseline or absolute value <50 mg/dL | -
10016750 | A disorder characterized by marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip. | Flank pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10016757 | A disorder characterized by a sudden or brief burst of light. | Flashing lights |  | Symptomatic but not limiting ADL | Limiting instrumental ADL | Limiting self care ADL | - | -
10016766 | A disorder characterized by a state of excessive gas in the alimentary canal. | Flatulence |  | Mild symptoms; intervention not indicated | Moderate; persistent; psychosocial sequelae | - | - | -
10016778 | A disorder characterized by an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens. | Floaters |  | Symptomatic but not limiting ADL | Limiting instrumental ADL | Limiting self care ADL | - | -
10016791 | A disorder characterized by a group of symptoms similar to those observed in patients with the flu. It includes fever, chills, body aches, malaise, loss of appetite and dry cough. | Flu like symptoms |  | Mild flu-like symptoms present | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10016825 | A disorder characterized by episodic reddening of the face. | Flushing |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; medical intervention indicated; limiting instrumental ADL | Symptomatic, associated with hypotension and/or tachycardia; limiting self care ADL | - | -
10016987 | A finding based on test results that indicate a relative decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds. | Forced expiratory volume decreased |  | FEV1% (percentages of observed FEV1 and FVC related to their respective predicted values)  99 - 70% predicted | FEV1 60 - 69% | 50 - 59% | <= 49% | -
10017076 | A finding of traumatic injury to the bone in which the continuity of the bone is broken. | Fracture |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic but non-displaced; immobilization indicated | Severe symptoms; displaced or open wound with bone exposure; disabling; operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10017577 | A disorder characterized by walking difficulties. | Gait disturbance |  | Mild change in gait (e.g., wide-based, limping or hobbling) | Moderate change in gait (e.g., wide-based, limping or hobbling); assistive device indicated; limiting instrumental ADL | Disabling; limiting self care ADL | - | -
10017631 | A disorder characterized by an abnormal communication between the gallbladder and another organ or anatomic site. | Gallbladder fistula |  | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Symptomatic or severely altered GI function; TPN indicated; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10017636 | A disorder characterized by blockage of the normal flow of the contents of the gallbladder. | Gallbladder obstruction |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; IV fluids indicated  <24 hrs | Symptomatic and severely altered GI function; tube feeding, [NAME] or hospitalization indicated; non-emergent operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10017638 | A disorder characterized by a sensation of marked discomfort in the gallbladder region. | Gallbladder pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10017639 | A disorder characterized by a rupture in the gallbladder wall. | Gallbladder perforation |  | - | - | - | Life-threatening consequences; urgent intervention indicated | Death
10017789 | A disorder characterized by bleeding from the gastric wall. | Gastric hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10017815 | A disorder characterized by a rupture in the stomach wall. | Gastric perforation |  | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10017822 | A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the stomach. | Gastric ulcer |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; medical intervention indicated; limiting instrumental ADL | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10017853 | A disorder characterized by inflammation of the stomach. | Gastritis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; medical intervention indicated | Severely altered eating or gastric function; [NAME] or hospitalization indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10017877 | A disorder characterized by an abnormal communication between any part of the gastrointestinal system and another organ or anatomic site. | Gastrointestinal fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding, [NAME] or hospitalization indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10017947 |  | Gastrointestinal disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10017999 | A disorder characterized by a sensation of marked discomfort in the gastrointestinal region. | Gastrointestinal pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10018043 | A disorder characterized by an incomplete paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine. | Gastroparesis |  | Mild nausea, early satiety and bloating, able to maintain caloric intake on regular diet | Moderate symptoms; able to maintain nutrition with dietary and lifestyle modifications; may need pharmacologic intervention | Weight loss; refractory to medical intervention; unable to maintain nutrition orally | - | -
10018065 |  | General disorders and administration site conditions - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10018146 | A disorder characterized by swelling due to an excessive accumulation of fluid in the genitals. | Genital edema |  | Mild swelling or obscuration of anatomic architecture on close inspection | Readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour | Lymphorrhea; gross deviation from normal anatomic contour; limiting self care ADL | - | -
10018286 | A disorder characterized by a sensation of marked discomfort in the gingival region. | Gingival pain |  | Mild pain | Moderate pain interfering with oral intake | Severe pain; inability to aliment orally | - | -
10018304 | A disorder characterized by an increase in pressure in the eyeball due to obstruction of the aqueous humor outflow. | Glaucoma |  | Elevated intraocular pressure (EIOP) with single topical agent for intervention; no visual field deficit | EIOP causing early visual field deficits; multiple topical or oral agents indicated; limiting instrumental ADL | EIOP causing marked visual field deficits (e.g., involving both superior and inferior visual fields); operative intervention indicated; limiting self care ADL | Blindness (20/200 or worse) in the affected eye | -
10018746 | A disorder characterized by greater growth than expected for age. | Growth accelerated |  | - | >= +2 SD (standard deviation) above mid parental height or target height | - | - | -
10018748 | A finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen. | Growth hormone abnormal |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated; limiting instrumental ADL | - | - | -
10018761 | A disorder characterized by of stature that is smaller than normal as expected for age. | Growth suppression |  | Reduction in growth velocity by 10 - 29% ideally measured over the period of a year | Reduction in growth velocity by 30 - 49% ideally measured over the period of a year or 0 - 49% reduction in growth from the baseline growth curve | Reduction in growth velocity of >=50% ideally measured over the period of a year | - | -
10018784 | A disorder characterized by an infectious process involving the gums. | Gum infection |  | Local therapy indicated (swish and swallow) | Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10018801 | A disorder characterized by excessive development of the breasts in males. | Gynecomastia |  | Asymptomatic breast enlargement | Symptomatic (e.g., pain or psychosocial impact) | Severe symptoms; elective operative intervention indicated | - | -
10019077 | A disorder characterized by a false sensory perception in the absence of an external stimulus. | Hallucinations |  | Mild hallucinations (e.g., perceptual distortions) | Moderate hallucinations | Severe hallucinations; hospitalization not indicated | Life-threatening consequences,  threats of harm to self or others; hospitalization indicated | Death
10019150 | A finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen. | Haptoglobin decreased |  | <LLN | - | - | - | -
10019211 | A disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve. | Headache |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10019245 | A disorder characterized by partial or complete loss of the ability to detect or understand sounds resulting from damage to ear structures. | Hearing impaired |  | Adults enrolled on a monitoring program (a 1, 2, 3, 4, 6 and 8 kHz audiogram): threshold shift of 15 - 25 dB averaged at 2 contiguous test frequencies in at least one ear or subjective change in the absence of a Grade 1 threshold shift  Pediatric (a 1, 2, 3, 4, 6 and 8 kHz audiogram): >20 dB at any frequency tested and does not meet criteria for >Grade 2 | Adults enrolled in monitoring program (a 1, 2, 3, 4, 6 and 8 kHz  audiogram):  threshold shift of >25 dB averaged at 2 contiguous test frequencies in at least one ear  [NAME] not enrolled in monitoring program: hearing loss but hearing aid or intervention not indicated; limiting instrumental ADL  Pediatric (a 1, 2, 3, 4, 6 and 8 kHz audiogram):  >20 dB at >4 kHz | Adults enrolled in monitoring program (a 1, 2, 3, 4, 6 and 8 kHz audiogram): threshold shift of >25 dB averaged at 3 contiguous test frequencies in at least one ear; therapeutic intervention indicated   Adults not enrolled in monitoring program:  hearing loss with hearing aid or intervention indicated; limiting self care ADL   Pediatric (a 1, 2, 3, 4, 6 and 8 kHz audiogram): hearing loss sufficient to indicate therapeutic intervention, including hearing aids; >20 dB at 3 kHz and above in one ear; additional speech-language related services indicated | Adults: profound bilateral hearing loss (>80 dB at 2 kHz and above); non-serviceable hearing  Pediatric: audiologic indication for cochlear implant and additional speech-language related services indicated | -
10019279 | A disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure. | Heart failure |  | Asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities | Symptoms with mild to moderate activity or exertion | Severe with symptoms at rest or with minimal activity or exertion; intervention indicated | Life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support) | Death
10019428 | A disorder characterized by a localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel. | Hematoma |  | Mild symptoms; intervention not indicated | Minimally invasive evacuation or aspiration indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10019450 | A disorder characterized by laboratory test results that indicate blood in the urine. | Hematuria |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; urinary catheter or bladder irrigation indicated; limiting instrumental ADL | Gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated; limiting self care ADL | Life-threatening consequences; urgent radiologic or operative intervention indicated | Death
10019489 | A disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine. | Hemoglobinuria |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | - | - | - | -
10019491 | A disorder characterized by laboratory test results that indicate widespread erythrocyte cell membrane destruction. | Hemolysis |  | Laboratory evidence of hemolysis only (e.g., direct antiglobulin test; DAT; Coombs'; schistocytes; decreased haptoglobin) | Evidence of hemolysis and >=2 gm decrease in hemoglobin, no transfusion | Transfusion or medical intervention indicated (e.g., steroids) | Life-threatening consequences; urgent intervention indicated | Death
10019515 | A disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia. | Hemolytic uremic syndrome |  | Evidence of RBC destruction (schistocytosis) without clinical consequences | - | Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae) | Life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure) | Death
10019611 | A disorder characterized by the presence of dilated veins in the rectum and surrounding area. | Hemorrhoids |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; banding or medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | - | -
10019663 | A disorder characterized by the inability of the liver to metabolize chemicals in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase. | Hepatic failure |  | - | - | Asterixis; mild encephalopathy; limiting self care ADL | Moderate to severe encephalopathy; coma; life-threatening consequences | Death
10019678 | A disorder characterized by bleeding from the liver. | Hepatic hemorrhage |  | Mild; intervention not indicated | Symptomatic; medical intervention indicated | Transfusion indicated | Life-threatening consequences; urgent intervention indicated | Death
10019692 | A disorder characterized by a necrotic process occurring in the hepatic parenchyma. | Hepatic necrosis |  | - | - | - | Life-threatening consequences; urgent radiologic or operative intervention indicated | Death
10019705 | A disorder characterized by a sensation of marked discomfort in the liver region. | Hepatic pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10019799 | A disorder characterized by a viral pathologic process involving the liver parenchyma. | Hepatitis viral |  | Asymptomatic, treatment not indicated | - | Symptomatic liver dysfunction; fibrosis by biopsy; compensated cirrhosis; reactivation of chronic hepatitis | Decompensated liver function (e.g., ascites, coagulopathy, encephalopathy, coma) | Death
10019805 |  | Hepatobiliary disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10020039 | A disorder characterized by repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm. | Hiccups |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated; limiting instrumental ADL | Severe symptoms; interfering with sleep; limiting self care ADL | - | -
10020100 | A finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken. | Hip fracture |  | - | Hairline fracture; mild pain; limiting instrumental ADL; non-surgical intervention indicated | Severe pain; hospitalization or intervention indicated for pain control (e.g., traction); operative intervention indicated | Life-threatening consequences; symptoms associated with neurovascular compromise | -
10020112 | A disorder characterized by the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen). | Hirsutism |  | In women, increase in length, thickness or density of hair in a male distribution that the patient is able to camouflage by periodic shaving, bleaching, or removal of hair | In women, increase in length, thickness or density of hair in a male distribution that requires daily shaving or consistent destructive means of hair removal to camouflage; associated with psychosocial impact | - | - | -
10020201 | A disorder characterized by harsh and [NAME] voice arising from or spreading to the larynx. | Hoarseness |  | Mild or intermittent voice change; fully understandable; self-resolves | Moderate or persistent voice changes; may require occasional repetition but understandable on telephone; medical evaluation indicated | Severe voice changes including predominantly whispered speech | - | -
10020407 | A disorder characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling. | Hot flashes |  | Mild symptoms; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10020508 | A disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain. | Hydrocephalus |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; intervention not indicated | Severe symptoms or neurological deficit; intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10020587 | A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium in blood. | Hypercalcemia |  | >ULN - 11.5 mg/dL; >ULN - 2.9 mmol/L;  Ionized calcium  >ULN - 1.5 mmol/L | >11.5 - 12.5 mg/dL; >2.9 - 3.1 mmol/L;  Ionized calcium >1.5 - 1.6 mmol/L; symptomatic | >12.5 - 13.5 mg/dL;>3.1 - 3.4 mmol/L;  Ionized calcium  >1.6 - 1.8 mmol/L; hospitalization indicated | >13.5 mg/dL; >3.4 mmol/L;  Ionized calcium  >1.8 mmol/L; life-threatening consequences | Death
10020639 | A disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance. | Hyperglycemia |  | Fasting glucose value >ULN - 160 mg/dL; Fasting glucose value >ULN - 8.9 mmol/L | Fasting glucose value >160 - 250 mg/dL; Fasting glucose value >8.9 - 13.9 mmol/L | >250 - 500 mg/dL; >13.9 - 27.8 mmol/L; hospitalization indicated | >500 mg/dL; >27.8 mmol/L; life-threatening consequences | Death
10020642 | A disorder characterized by excessive perspiration. | Hyperhidrosis |  | Limited to one site (palms, soles, or axillae); self care interventions | Involving >1 site; patient seeks medical intervention; associated with psychosocial impact | Generalized involving sites other than palms, soles, or axillae; associated with electrolyte/hemodynamic imbalance | - | -
10020647 | A disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs. | Hyperkalemia |  | >ULN - 5.5 mmol/L | >5.5 - 6.0 mmol/L | >6.0 - 7.0 mmol/L; hospitalization indicated | >7.0 mmol/L; life-threatening consequences | Death
10020670 | A disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the  blood. | Hypermagnesemia |  | >ULN - 3.0 mg/dL; >ULN - 1.23 mmol/L | - | >3.0 - 8.0 mg/dL; >1.23 - 3.30 mmol/L | >8.0 mg/dL; >3.30 mmol/L; life-threatening consequences | Death
10020680 | A disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the  blood. | Hypernatremia |  | >ULN - 150 mmol/L | >150 - 155 mmol/L | >155 - 160 mmol/L; hospitalization indicated | >160 mmol/L; life-threatening consequences | Death
10020705 | A disorder characterized by an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood). | Hyperparathyroidism |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | - | - | -
10020765 | A disorder characterized by characterized by excessive sleepiness during the daytime. | Hypersomnia |  | Mild increased need for sleep | Moderate increased need for sleep | Severe increased need for sleep | - | -
10020772 | A disorder characterized by a pathological increase in blood pressure; a repeatedly elevation in the blood pressure exceeding 140 over 90 mm Hg. | Hypertension |  | Prehypertension (systolic BP 120 - 139 mm Hg or diastolic BP  80 - 89 [NAME]) | Stage 1 hypertension (systolic BP 140 - 159 mm Hg or diastolic BP 90 - 99 mm Hg); medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg if previously WNL; monotherapy indicated  Pediatric: recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated | Stage 2 hypertension (systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg); medical intervention indicated; more than one drug or more intensive therapy than previously used indicated  Pediatric: Same as adult | Life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated  Pediatric: Same as adult | Death
10020850 | A disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose. | Hyperthyroidism |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; thyroid suppression therapy indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL; hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death
10020864 | A disorder characterized by hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race. | Hypertrichosis |  | Increase in length, thickness or density of hair that the patient is either able to camouflage by periodic shaving or removal of hairs or is not concerned enough about the overgrowth to use any form of hair removal | Increase in length, thickness or density of hair at least on the usual exposed areas of the body [face (not limited to beard/moustache area) plus/minus arms] that requires frequent  shaving or use of destructive means of hair removal to camouflage; associated with psychosocial impact | - | - | -
10020870 | A disorder characterized by laboratory test results that indicate an elevation in the concentration of triglyceride concentration in the blood. | Hypertriglyceridemia |  | 150 mg/dL - 300 mg/dL; 1.71 mmol/L - 3.42 mmol/L | >300 mg/dL - 500 mg/dL;  >3.42 mmol/L - 5.7 mmol/L | >500 mg/dL - 1000 mg/dL;  >5.7 mmol/L - 11.4 mmol/L | >1000 mg/dL; >11.4 mmol/L;  life-threatening consequences | Death
10020907 | A disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid. | Hyperuricemia |  | >ULN - 10 mg/dL; <=0.59 mmol/L without physiologic consequences | - | >ULN - 10 mg/dL; <=0.59 mmol/L with physiologic consequences | >10 mg/dL; >0.59 mmol/L; life-threatening consequences | Death
10020943 | A disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood. | Hypoalbuminemia |  | <LLN - 3 g/dL; <LLN - 30 g/L | <3 - 2 g/dL; <30 - 20 g/L | <2 g/dL; <20 g/L | Life-threatening consequences; urgent intervention indicated | Death
10020949 | A disorder characterized by laboratory test results that indicate a low concentration of calcium in the  blood. | Hypocalcemia |  | <LLN - 8.0 mg/dL; <LLN - 2.0 mmol/L; Ionized calcium  <LLN - 1.0 mmol/L | <8.0 - 7.0 mg/dL; <2.0 - 1.75 mmol/L; Ionized calcium  <1.0 - 0.9 mmol/L; symptomatic | <7.0 - 6.0 mg/dL; <1.75 - 1.5 mmol/L;  Ionized calcium  <0.9 - 0.8 mmol/L; hospitalization indicated | <6.0 mg/dL; <1.5 mmol/L;  Ionized calcium  <0.8 mmol/L; life-threatening consequences | Death
10021005 | A disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood. | Hypoglycemia |  | <LLN - 55 mg/dL; <LLN - 3.0 mmol/L | <55 - 40 mg/dL; <3.0 - 2.2 mmol/L | <40 - 30 mg/dL; <2.2 - 1.7 mmol/L | <30 mg/dL; <1.7 mmol/L; life-threatening consequences; seizures | Death
10021013 | A disorder characterized by reduced sweating. | Hypohidrosis |  | - | Symptomatic; limiting instrumental ADL | Increase in body temperature; limiting self care ADL | Heat stroke | Death
10021018 | A disorder characterized by laboratory test results that indicate a low concentration of potassium in the  blood. | Hypokalemia |  | <LLN - 3.0 mmol/L | <LLN - 3.0 mmol/L; symptomatic; intervention indicated | <3.0 - 2.5 mmol/L; hospitalization indicated | <2.5 mmol/L; life-threatening consequences | Death
10021028 | A disorder characterized by laboratory test results that indicate a low concentration of magnesium in the  blood. | Hypomagnesemia |  | <LLN - 1.2 mg/dL; <LLN - 0.5 mmol/L | <1.2 - 0.9 mg/dL; <0.5 - 0.4 mmol/L | <0.9 - 0.7 mg/dL; <0.4 - 0.3 mmol/L | <0.7 mg/dL; <0.3 mmol/L; life-threatening consequences | Death
10021038 | A disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood. | Hyponatremia |  | <LLN - 130 mmol/L | - | <130 - 120 mmol/L | <120 mmol/L; life-threatening consequences | Death
10021041 | A disorder characterized by a decrease in production of parathyroid hormone by the parathyroid glands. | Hypoparathyroidism |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; medical intervention indicated | Severe symptoms; medical intervention or hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death
10021059 | A disorder characterized by laboratory test results that indicate a low concentration of phosphates in the  blood. | Hypophosphatemia |  | <LLN - 2.5 mg/dL; <LLN - 0.8 mmol/L | <2.5 - 2.0 mg/dL; <0.8 - 0.6 mmol/L | <2.0 - 1.0 mg/dL; <0.6 - 0.3 mmol/L | <1.0 mg/dL; <0.3 mmol/L; life-threatening consequences | Death
10021097 | A disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment. | Hypotension |  | Asymptomatic, intervention not indicated | Non-urgent medical intervention indicated | Medical intervention or hospitalization indicated | Life-threatening and urgent intervention indicated | Death
10021113 | A disorder characterized by an abnormally low body temperature. Treatment is required when the body temperature is 35C (95F) or below. | Hypothermia |  | - | 35 - >32 degrees C;  95 - >89.6 degrees F | 32 - >28 degrees C;  89.6 - >82.4 degrees F | <=28 degrees C; 82.4 degrees F; life-threatening consequences (e.g., coma, hypotension, pulmonary edema, acidemia, ventricular fibrillation) | Death
10021114 | A disorder characterized by a decrease in production of thyroid hormone by the thyroid gland. | Hypothyroidism |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; thyroid replacement indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL; hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death
10021143 | A disorder characterized by a decrease in the level of oxygen in the body. | Hypoxia |  | - | Decreased oxygen saturation with exercise (e.g., pulse oximeter <88%); intermittent supplemental oxygen | Decreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 <=55 mm Hg) | Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) | Death
10021305 | A disorder characterized by a rupture in the ileal wall. | Ileal perforation |  | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10021307 | A disorder characterized by a narrowing of the lumen of the ileum. | Ileal stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10021309 | A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the ileum. | Ileal ulcer |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10021328 | A disorder characterized by failure of the ileum to transport intestinal contents. | Ileus |  | - | Symptomatic; altered GI function; bowel rest indicated | Severely altered GI function; TPN indicated | Life-threatening consequences; urgent intervention indicated | Death
10021428 |  | Immune system disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10021881 |  | Infections and infestations - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10021918 | A disorder characterized by an infectious process involving the skeletal muscles. | Infective myositis |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10022095 | A disorder characterized by an intense adverse reaction (usually immunologic) developing at the site of an injection. | Injection site reaction |  | Tenderness with or without associated symptoms (e.g., warmth, erythema, itching) | Pain; lipodystrophy; edema; phlebitis | Ulceration or necrosis; severe tissue damage; operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10022117 |  | Injury, poisoning and procedural complications - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10022161 | A finding of damage to the carotid artery. | Injury to carotid artery |  | - | - | Severe symptoms; limiting self care ADL (e.g., transient cerebral ischemia); repair or revision indicated | Life-threatening consequences; urgent intervention indicated | Death
10022213 | A finding of damage to the inferior vena cava. | Injury to inferior vena cava |  | - | - | - | Life-threatening consequences; urgent intervention indicated | Death
10022356 | A finding of damage to the superior vena cava. | Injury to superior vena cava |  | Asymptomatic diagnostic finding; intervention not indicated | Symptomatic; repair or revision not indicated | Severe symptoms; limiting self care ADL; disabling; repair or revision indicated | Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated | Death
10022402 | A finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood. | INR increased |  | >1 - 1.5 x ULN; >1 - 1.5 times above baseline if on anticoagulation | >1.5 - 2.5 x ULN; >1.5 - 2.5 times above baseline if on anticoagulation | >2.5 x ULN; >2.5 times above baseline if on anticoagulation | - | -
10022437 | A disorder characterized by difficulty in falling asleep and/or remaining asleep. | Insomnia |  | Mild difficulty falling asleep, staying asleep or waking up early | Moderate difficulty falling asleep, staying asleep or waking up early | Severe difficulty in falling asleep, staying asleep or waking up early | - | -
10022763 | A disorder characterized by bleeding from the cranium. | Intracranial hemorrhage |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; medical intervention indicated | [NAME], ICP monitoring, intraventricular thrombolysis, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10022891 |  | Investigations - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10022992 | A disorder characterized by irregular cycle or duration of menses. | Irregular menstruation |  | Intermittent menses with skipped menses for no more than 1 to 3 months | Intermittent menses with skipped menses for more than 4 to 6 months | Persistent amenorrhea for more than 6 months | - | -
10022998 | A disorder characterized by an abnormal responsiveness to stimuli or physiological arousal; may be in response to pain, fright, a drug, an emotional situation or a medical condition. | Irritability |  | Mild; easily consolable | Moderate; limiting instrumental ADL; increased attention indicated | Severe abnormal or excessive response; limiting self care ADL; inconsolable | - | -
10023030 | A disorder characterized by a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage. | Ischemia cerebrovascular |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms | - | - | -
10023174 | A disorder characterized by a rupture in the jejunal wall. | Jejunal perforation |  | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10023176 | A disorder characterized by a narrowing of the lumen of the jejunum. | Jejunal stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10023177 | A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the jejunum. | Jejunal ulcer |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10023215 | A disorder characterized by excessive fluid in a joint, usually as a result of joint inflammation. | Joint effusion |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; limiting instrumental ADL | Severe symptoms; limiting self care ADL; elective operative intervention indicated; disabling | - | -
10023216 | A disorder characterized by an infectious process involving a joint. | Joint infection |  | - | Localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral); needle aspiration indicated (single or multiple) | Arthroscopic intervention indicated (e.g., drainage) or arthrotomy (e.g., open surgical drainage) | Life-threatening consequences; urgent intervention indicated | Death
10023332 | A disorder characterized by inflammation to the cornea of the eye. | Keratitis |  | - | Symptomatic; medical intervention indicated (e.g., topical agents); limiting instrumental ADL | Decline in vision (worse than 20/40 but better than 20/200); limiting self care ADL | Perforation or blindness (20/200 or worse) in the affected eye | -
10023424 | A disorder characterized by an infectious process involving the kidney. | Kidney infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10023509 | A disorder characterized by an abnormal increase in the curvature of the thoracic portion of the spine. | Kyphosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate accentuation; limiting instrumental ADL | Severe accentuation; operative intervention indicated; limiting self care ADL | - | -
10023838 | A disorder characterized by swelling due to an excessive accumulation of fluid in the larynx. | Laryngeal edema |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated (e.g., dexamethasone, epinephrine, antihistamines) | Stridor; respiratory distress; hospitalization indicated | Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) | Death
10023862 | A disorder characterized by a narrowing of the laryngeal airway. | Laryngeal stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids) | Limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) | Life-threatening consequences; urgent intervention indicated | Death
10023874 | A disorder characterized by an inflammatory process involving the larynx. | Laryngitis |  | - | Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10023891 | A disorder characterized by paroxysmal spasmodic muscular contraction of the vocal cords. | Laryngospasm |  | - | Transient episode; intervention not indicated | Recurrent episodes; noninvasive intervention indicated (e.g., breathing technique, pressure point massage) | Persistent or severe episodes associated with syncope; urgent intervention indicated (e.g., fiberoptic laryngoscopy, intubation, botox injection) | Death
10024264 | A disorder characterized by a decrease in consciousness characterized by mental and physical inertness. | Lethargy |  | Mild symptoms; reduced alertness and awareness | Moderate symptoms; limiting instrumental ADL | - | - | -
10024378 | A disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood. | Leukocytosis |  | - | - | >100,000/mm3 | Clinical manifestations of leucostasis; urgent intervention indicated | Death
10024382 | A disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation. | [NAME] |  | Asymptomatic; small focal T2/FLAIR hyperintensities; involving periventricular white matter or <1/3 of susceptible areas of cerebrum +/- mild increase in subarachnoid space (SAS) and/or mild ventriculomegaly | Moderate symptoms; focal T2/FLAIR hyperintensities, involving periventricular white matter extending into centrum semiovale or involving 1/3 to 2/3 of susceptible areas of cerebrum +/- moderate increase in SAS and/or moderate ventriculomegaly | Severe symptoms; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving 2/3 or more of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly | Life-threatening consequences; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving most of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly | Death
10024419 | A disorder characterized by a decrease in sexual desire. | Libido decreased |  | Decrease in sexual interest not adversely affecting relationship | Decrease in sexual interest adversely affecting relationship | - | - | -
10024421 | A disorder characterized by an increase in sexual desire. | Libido increased |  | Mild increase in sexual interest not adversely affecting relationship | Moderate increase in sexual interest adversely affecting relationship | Severe increase in sexual interest leading to dangerous behavior | - | -
10024561 | A disorder characterized by a sensation of marked discomfort of the lip. | Lip pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10024574 | A finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen. | Lipase increased |  | >ULN - 1.5 x ULN | >1.5 - 2.0 x ULN | >2.0 - 5.0 x ULN | >5.0 x ULN | -
10024842 | A disorder characterized by an abnormal increase in the curvature of the lumbar portion of the spine. | Lordosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate accentuation; limiting instrumental ADL | Severe accentuation; operative intervention indicated; limiting self care ADL | - | -
10025182 | A disorder characterized by a sensation of marked discomfort in a lymph node. | Lymph node pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | -
10025233 | A disorder characterized by excessive fluid collection in tissues that causes swelling. | Lymphedema |  | Trace thickening or faint discoloration | Marked discoloration; leathery skin texture; papillary formation; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10025256 | A finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen. | [NAME] count decreased |  | <LLN - 800/mm3; <LLN x 0.8 - 10e9 /L | <800 - 500/mm3; <0.8 - 0.5 x 10e9 /L | <500 - 200/mm3; <0.5 - 0.2 x 10e9 /L | <200/mm3; <0.2 x 10e9 /L | -
10025258 | A finding based on laboratory test results that indicate an abnormal increase in the number of lymphocytes in the blood, effusions or bone marrow. | [NAME] count increased |  |  | >4000/mm3 - 20,000/mm3 | >20,000/mm3 | - | -
10025476 | A disorder characterized by inadequate absorption of nutrients in the small intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea. | Malabsorption |  | - | Altered diet; oral intervention indicated | Inability to aliment adequately; TPN indicated | Life-threatening consequences; urgent intervention indicated | Death
10025482 | A disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling. | Malaise |  | Uneasiness or lack of well being | Uneasiness or lack of well being; limiting instrumental ADL | - | - | -
10026749 | A disorder characterized by excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood. | Mania |  | Mild manic symptoms (e.g., elevated mood, rapid thoughts, rapid speech, decreased need for sleep) | Moderate manic symptoms (e.g., relationship and work difficulties; poor hygiene) | Severe manic symptoms (e.g., [NAME]; major sexual or financial indiscretions); hospitalization not indicated | Life-threatening consequences,  threats of harm to self or others; hospitalization indicated | Death
10027175 | A disorder characterized by a deterioration in memory function. | Memory impairment |  | Mild memory impairment | Moderate memory impairment; limiting instrumental ADL | Severe memory impairment; limiting self care ADL | - | -
10027198 | A disorder characterized by neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges. | Meningismus |  | Mild symptoms | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10027199 | A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord. | Meningitis |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated; focal neurologic deficit | Life-threatening consequences; urgent intervention indicated | Death
10027308 | A disorder characterized by the permanent cessation of menses, usually defined by 12 consecutive months of amenorrhea in a woman over 45 years of age. | Menopause |  | Menopause occurring at age 46 - 53 years of age | Menopause occurring at age 40 - 45 years of age | Menopause occurring before age 40 years of age | - | -
10027313 | A disorder characterized by abnormally heavy vaginal bleeding during menses. | Menorrhagia |  | Mild; iron supplements indicated | Moderate symptoms; medical intervention indicated (e.g., hormones) | Severe; transfusion indicated; surgical intervention indicated (e.g., hysterectomy) | Life-threatening consequences; urgent intervention indicated | Death
10027433 |  | Metabolism and nutrition disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10027786 | A disorder characterized by a dysrhythmia with relatively constant PR interval prior to the block of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles. | Mobitz (type) II atrioventricular block |  | Asymptomatic, intervention not indicated | Symptomatic; medical intervention indicated | Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) | Life-threatening consequences; urgent intervention indicated | Death
10027787 | A disorder characterized by a dysrhythmia with a progressively lengthening PR interval prior to the blocking of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles. | Mobitz type I |  | Asymptomatic, intervention not indicated | Symptomatic; medical intervention indicated | Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) | Life-threatening consequences; urgent intervention indicated | Death
10028041 | A disorder characterized by uncontrolled and purposeless movements. | Movements involuntary |  | Mild symptoms | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10028130 | A disorder characterized by inflammation of the oral mucosal. | Mucositis oral |  | Asymptomatic or mild symptoms; intervention not indicated | Moderate pain; not interfering with oral intake; modified diet indicated | Severe pain; interfering with oral intake | Life-threatening consequences; urgent intervention indicated | Death
10028154 | A disorder characterized by progressive deterioration of the lungs, liver, kidney and clotting mechanisms. | Multi-organ failure |  | - | - | Shock with azotemia and acid-base disturbances; significant coagulation abnormalities | Life-threatening consequences (e.g., vasopressor dependent and oliguric or anuric or ischemic colitis or lactic acidosis) | Death
10028395 | - | Musculoskeletal and connective tissue disorder -  Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10028411 | A disorder characterized by marked discomfort sensation originating from a muscle or group of muscles. | Myalgia |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10028524 | A disorder characterized by inflammation involving the spinal cord. Symptoms include weakness, paresthesia, sensory loss, marked discomfort and incontinence. | Myelitis |  | Asymptomatic; mild signs (e.g., [NAME]'s reflex or Lhermitte's sign) | Moderate weakness or sensory loss; limiting instrumental ADL | Severe weakness or sensory loss; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10028533 | A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow. | Myelodysplastic syndrome |  | - | - | - | Life-threatening consequences; urgent intervention indicated | Death
10028596 | A disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area. | Myocardial infarction |  | - | Asymptomatic and cardiac enzymes minimally abnormal and no evidence of ischemic ECG changes | Severe symptoms; cardiac enzymes abnormal; hemodynamically stable; ECG changes consistent with infarction | Life-threatening consequences; hemodynamically unstable | Death
10028606 | A disorder characterized by inflammation of the muscle tissue of the heart. | Myocarditis |  | Asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities | Symptoms with mild to moderate activity or exertion | Severe with symptoms at rest or with minimal activity or exertion; intervention indicated | Life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support) | Death
10028653 | A disorder characterized by inflammation involving the skeletal muscles. | Myositis |  | Mild pain | Moderate pain associated with weakness; pain limiting instrumental ADL | Pain associated with severe weakness; limiting self care ADL | - | -
10028691 | A disorder characterized by a change in the color of the nail plate. | Nail discoloration |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated |  | - | - | -
10028735 | A disorder characterized by obstruction of the nasal passage due to mucosal edema. | Nasal congestion |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | Associated with bloody nasal discharge or epistaxis | - | -
10028813 | A disorder characterized by a queasy sensation and/or the urge to vomit. | Nausea |  | Loss of appetite without alteration in eating habits | Oral intake decreased without significant weight loss, dehydration or malnutrition | Inadequate oral caloric or fluid intake; tube feeding, [NAME], or hospitalization indicated | - | -
10028836 | A disorder characterized by marked discomfort sensation in the neck area. | Neck pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10029104 | - | Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10029205 | - | Nervous system disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10029223 | A disorder characterized by intense painful sensation along a nerve or group of nerves. | Neuralgia |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10029366 | A finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen. | Neutrophil count decreased |  | <LLN - 1500/mm3; <LLN - 1.5 x 10e9 /L | <1500 - 1000/mm3; <1.5 - 1.0 x 10e9 /L | <1000 - 500/mm3; <1.0 - 0.5 x 10e9 /L | <500/mm3; <0.5 x 10e9 /L | -
10029404 | A disorder characterized by an inability to see clearly in dim light. | Night blindness |  | Symptomatic but not limiting ADL | Limiting instrumental ADL | Limiting self care ADL | Blindness (20/200 or worse) in the affected eye | -
10029864 | A disorder characterized by involuntary movements of the eyeballs. | Nystagmus |  | - | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10029883 | A disorder characterized by having a high amount of body fat. | Obesity |  | - | BMI 25 - 29.9 kg/m2 | BMI 30 - 39.9 kg/m2 | BMI >=40 kg/m2
10029957 | A disorder characterized by blockage of the normal flow of the contents in the stomach. | Obstruction gastric |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Hospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10030300 | A disorder characterized by a decrease in the number of spermatozoa in the semen. | Oligospermia |  | Sperm concentration >48 million/mL or motility >68% | Sperm concentration 13 - 48 million/mL or motility 32 - 68% | Sperm concentration <13 million/mL or motility <32% | - | -
10030980 | A disorder characterized by bleeding from the mouth. | Oral hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10031009 | A disorder characterized by a sensation of marked discomfort in the mouth, tongue or lips. | Oral pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10031282 | A disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. | Osteoporosis |  | Radiologic evidence of osteoporosis or Bone Mineral Density (BMD) t-score -1 to -2.5 (osteopenia); no loss of height or intervention indicated | BMD t-score <-2.5; loss of height <2 cm; anti-osteoporotic therapy indicated; limiting instrumental ADL | Loss of height >=2 cm; hospitalization indicated; limiting self care ADL | - | -
10033072 | A disorder characterized by an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage. | Otitis externa |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10033078 | A disorder characterized by an infectious process involving the middle ear. | Otitis media |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10033279 | A disorder characterized by tearing or disruption of the ovarian tissue. | Ovarian rupture |  | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10033314 | A disorder characterized by marked discomfort sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle. | Ovulation pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10033371 | A disorder characterized by the sensation of marked discomfort, distress or agony. | Pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10033425 | A disorder characterized by marked discomfort sensation in the upper or lower extremities. | Pain in extremity |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10033474 | A disorder characterized by marked discomfort sensation in the skin. | Pain of skin |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10033557 | A disorder characterized by an unpleasant sensation of irregular and/or forceful beating of the heart. | Palpitations |  | Mild symptoms; intervention not indicated | Intervention indicated | - | - | -
10033626 | A disorder characterized by bleeding from the pancreas. | Pancreatic hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10033645 | A disorder characterized by inflammation of the pancreas. | Pancreatitis |  | - | Enzyme elevation or radiologic findings only | Severe pain; vomiting; medical intervention indicated (e.g., [NAME], nutritional support) | Life-threatening consequences; urgent intervention indicated | Death
10033703 | A disorder characterized by swelling around the optic disc. | Papilledema |  | Asymptomatic; no visual field defects | Symptomatic decline in vision; visual field defect present sparing the central 20 degrees | Marked visual field defect (worse than 20/40 but better than 20/200) | Blindness (20/200 or worse) in the affected eye | -
10033987 | A disorder characterized by functional disturbances of sensory neurons resulting in abnormal cutaneous sensations of tingling, numbness, pressure, cold, and warmth that are experienced in the absence of a stimulus. | Paresthesia |  | Mild symptoms | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10034016 | A disorder characterized by an infectious process involving the soft tissues around the nail. | Paronychia |  | Nail fold edema or erythema; disruption of the cuticle | Localized intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral); nail fold edema or erythema with pain; associated with discharge or nail plate separation; limiting instrumental ADL | Surgical intervention or IV antibiotics indicated; limiting self care ADL | - | -
10034040 | A disorder characterized by a dysrhythmia with abrupt onset and sudden termination of atrial contractions with a rate of 150-250 beats per minute. The rhythm disturbance originates in the atria. | Paroxysmal atrial tachycardia |  | Asymptomatic, intervention not indicated | Symptomatic; medical management indicated | IV medication indicated | Life-threatening consequences; incompletely controlled medically; cardioversion indicated | Death
10034263 | A disorder characterized by marked discomfort sensation in the pelvis. | Pelvic pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10034310 | A disorder characterized by marked discomfort sensation in the penis. | Penile pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10034405 | A disorder characterized by a rupture in the wall of the extrahepatic or intrahepatic bile duct. | Perforation bile duct |  | - | - | Radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10034474 | A disorder characterized by fluid collection within the pericardial sac, usually due to inflammation. | Pericardial effusion |  | - | Asymptomatic effusion size small to moderate | Effusion with physiologic consequences | Life-threatening consequences; urgent intervention indicated | Death
10034484 | A disorder characterized by irritation to the layers of the pericardium (the protective sac around the heart). | Pericarditis |  | Asymptomatic, ECG or physical findings (e.g., rub) consistent with pericarditis | Symptomatic pericarditis (e.g., chest pain) | Pericarditis with physiologic consequences (e.g., pericardial constriction) | Life-threatening consequences; urgent intervention indicated | Death
10034536 | A disorder in the gingival tissue around the teeth. | Periodontal disease |  | Gingival recession or gingivitis; limited bleeding on probing; mild local bone loss | Moderate gingival recession or gingivitis; multiple sites of bleeding on probing; moderate bone loss | Spontaneous bleeding; severe bone loss with or without tooth loss; osteonecrosis of maxilla or mandible | - | -
10034578 | A disorder characterized by impaired circulation to an extremity. | Peripheral ischemia |  | - | Brief (<24 hrs) episode of ischemia managed non-surgically and without permanent deficit | Recurring or prolonged (>=24 hrs) and/or invasive intervention indicated | Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated | Death
10034580 | A disorder characterized by inflammation or degeneration of the peripheral motor nerves. | Peripheral motor neuropathy |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL; assistive device indicated | Life-threatening consequences; urgent intervention indicated | Death
10034620 | A disorder characterized by inflammation or degeneration of the peripheral sensory nerves. | Peripheral sensory neuropathy |  | Asymptomatic; loss of deep tendon reflexes or paresthesia | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10034719 | A disorder characterized by a conspicuous change in a person's behavior and thinking. | Personality change |  | Mild personality change | Moderate personality change | Severe personality change; hospitalization not indicated | Life-threatening consequences,  threats of harm to self or others; hospitalization indicated | Death
10034825 | A disorder characterized by an abnormal communication between the pharynx and another organ or anatomic site. | Pharyngeal fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) | Life-threatening consequences; urgent intervention indicated | Death
10034835 | A disorder characterized by inflammation of the throat. | Pharyngitis |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10034844 | A disorder characterized by marked discomfort sensation in the pharyngolaryngeal region. | Pharyngolaryngeal pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL
10034879 | A disorder characterized by inflammation of the wall of a vein. | Phlebitis |  | - | Present | - | - | -
10034960 | A disorder characterized by fear and avoidance of light. | Photophobia |  | Symptomatic but not limiting ADL | Limiting instrumental ADL | Limiting self care ADL | - | -
10034966 | A disorder characterized by an increase in sensitivity of the skin to light. | Photosensitivity |  | Painless erythema and erythema covering <10% BSA | Tender erythema covering 10 - 30% BSA | Erythema covering >30% BSA and erythema with blistering; photosensitivity; oral corticosteroid therapy indicated; pain control indicated (e.g., narcotics or NSAIDs) | Life-threatening consequences; urgent intervention indicated | Death
10035528 | A finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen. | Platelet count decreased |  | <LLN - 75,000/mm3; <LLN - 75.0 x 10e9 /L | <75,000 - 50,000/mm3; <75.0 - 50.0 x 10e9 /L | <50,000 - 25,000/mm3; <50.0 - 25.0 x 10e9 /L | <25,000/mm3; <25.0 x 10e9 /L | -
10035598 | A disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort. | Pleural effusion |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; intervention indicated (e.g., diuretics or limited therapeutic thoracentesis) | Symptomatic with respiratory distress and hypoxia; surgical intervention including chest tube or pleurodesis indicated | Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated | Death
10035623 | A disorder characterized by marked discomfort sensation in the pleura. | Pleuritic pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10035742 | A disorder characterized by inflammation focally or diffusely affecting the lung parenchyma. | Pneumonitis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL; oxygen indicated | Life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation) | Death
10035759 | A disorder characterized by abnormal presence of air in the pleural cavity resulting in the collapse of the lung. | Pneumothorax |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; intervention indicated (e.g., tube placement without sclerosis) | Sclerosis and/or operative intervention indicated; hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death
10036200 | A disorder characterized by an increase in blood pressure in the portal venous system. | Portal hypertension |  | - | Decreased portal vein flow | [NAME]/retrograde portal vein flow; associated with varices and/or ascites | Life-threatening consequences; urgent intervention indicated | Death
10036206 | A disorder characterized by the formation of a thrombus (blood clot) in the portal vein. | Portal vein thrombosis |  | - | Intervention not indicated | Medical intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10036402 | A disorder characterized by excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing. | Postnasal drip |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | - | - | -
10036585 | - | Pregnancy, puerperium and perinatal conditions - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate, local or noninvasive intervention indicated; limiting instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10036595 | A disorder characterized by delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation. | Premature delivery |  | Delivery of a liveborn infant at >34 to 37 weeks gestation | Delivery of a liveborn infant at >28 to 34 weeks gestation | Delivery of a liveborn infant at 24 to 28 weeks gestation | Delivery of a liveborn infant at 24 weeks of gestation or less | -
10036601 | A disorder characterized by ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive. | Premature menopause |  |  | - | Present | - | -
10036653 | A disorder characterized by an episode of lightheadedness and dizziness which may precede an episode of syncope. | Presyncope |  |  | Present (e.g., near fainting) | - | - | -
10036774 | A disorder characterized by inflammation of the rectum. | Proctitis |  | Rectal discomfort, intervention not indicated | Symptoms (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental ADL | Severe symptoms; fecal urgency or stool incontinence; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10036790 | A disorder characterized by expectorated secretions upon coughing. | Productive cough |  | Occasional/minimal production of sputum with cough | Moderate sputum production; limiting instrumental ADL | Persistent or copious production of sputum; limiting self care ADL | - | -
10036968 | A disorder characterized by a sensation of marked discomfort in the prostate gland. | Prostatic pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10037032 | A disorder characterized by laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin. | Proteinuria |  | 1+ proteinuria; urinary protein <1.0 g/24 hrs | Adults: 2+ proteinuria; urinary protein 1.0 - 3.4 g/24 hrs; Pediatric: urine P/C (Protein/Creatinine) ratio 0.5 - 1.9 | Adults: urinary protein >3.5 g/24 hrs;  Pediatric: urine P/C >1.9 | - | -
10037087 | A disorder characterized by an intense itching sensation. | Pruritus |  | Mild or localized; topical intervention indicated | Intense or widespread; intermittent; skin changes from scratching (e.g., edema, papulation, excoriations, lichenification, oozing/crusts); oral intervention indicated; limiting instrumental ADL | Intense or widespread; constant; limiting self care ADL or sleep; oral corticosteroid or immunosuppressive therapy indicated | - | -
10037175 | - | Psychiatric disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; disabling;  limiting self care ADL | Life-threatening consequences; hospitalization or urgent intervention indicated | Death
10037234 | A disorder characterized by personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor. | Psychosis |  | Mild psychotic symptoms | Moderate psychotic symptoms (e.g., disorganized speech; impaired reality testing) | Severe psychotic symptoms (e.g., paranoid; extreme disorganization); hospitalization not indicated | Life-threatening consequences,  threats of harm to self or others; hospitalization indicated | Death
10037375 | A disorder characterized by accumulation of fluid in the lung tissues that causes a disturbance of the gas exchange that may lead to respiratory failure. | [NAME] edema |  | Radiologic findings only; minimal dyspnea on exertion | Moderate dyspnea on exertion; medical intervention indicated; limiting instrumental ADL | Severe dyspnea or dyspnea at rest; oxygen indicated; limiting self care ADL | Life-threatening respiratory compromise; urgent intervention or intubation with ventilatory support indicated | Death
10037383 | A disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure or right heart failure. | [NAME] fibrosis |  | Mild hypoxemia; radiologic pulmonary fibrosis <25% of lung volume | Moderate hypoxemia; evidence of pulmonary hypertension; radiographic pulmonary fibrosis 25 - 50% | Severe hypoxemia; evidence of right-sided heart failure; radiographic pulmonary fibrosis >50 - 75% | Life-threatening consequences (e.g., hemodynamic/pulmonary complications); intubation with ventilatory support indicated; radiographic pulmonary fibrosis >75% with severe honeycombing | Death
10037400 | A disorder characterized by an increase in pressure within the pulmonary circulation due to lung or heart disorder. | [NAME] hypertension |  | Minimal dyspnea; findings on physical exam or other evaluation | Moderate dyspnea, cough; requiring evaluation by cardiac catheterization and medical intervention | Severe symptoms, associated with hypoxemia, right heart failure; oxygen indicated | Life-threatening airway consequences; urgent intervention indicated (e.g., tracheotomy or intubation) | Death
10037549 | A disorder characterized by hemorrhagic areas of the skin and mucous membrane. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color. | Purpura |  | Combined area of lesions covering <10% BSA | Combined area of lesions covering 10 - 30% BSA; bleeding with trauma | Combined area of lesions covering >30% BSA; spontaneous bleeding | - | -
10037767 | A finding of acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, for weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmaceutical agent. | Radiation recall reaction (dermatologic) |  | Faint erythema or dry desquamation | Moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema | Moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion | Life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated | Death
10037847 | A disorder characterized by an eruption of papules and pustules, typically appearing in face, scalp, upper chest and back. | Rash acneiform |  | [NAME] covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness | [NAME] covering 10 - 30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL | [NAME] covering >30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; limiting self care ADL; associated with local superinfection with oral antibiotics indicated | [NAME] covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences | Death
10037868 | A disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbillform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally and associated with pruritis. | Rash maculo-papular |  | Macules/papules covering <10% BSA with or without symptoms (e.g., pruritus, burning, tightness) | Macules/papules covering 10 - 30% BSA with or without symptoms (e.g., pruritus, burning, tightness); limiting instrumental ADL | Macules/papules covering >30% BSA with or without associated symptoms; limiting self care ADL | - | -
10037888 | A disorder characterized by a circumscribed and elevated skin lesion filled with pus. | Rash pustular |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | - | -
10038062 | A disorder characterized by an abnormal communication between the rectum and another organ or anatomic site. | Rectal fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; [NAME] or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10038064 | A disorder characterized by bleeding from the rectal wall and discharged from the anus. | Rectal hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10038072 | A disorder characterized by a sensation of marked discomfort in the rectal region. | Rectal pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10038073 | A disorder characterized by a rupture in the rectal wall. | Rectal perforation |  | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10038079 | A disorder characterized by a narrowing of the lumen of the rectum. | Rectal stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10038080 | A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the rectum. | Rectal ulcer |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function (e.g. altered dietary habits, vomiting, diarrhea) | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10038130 | A disorder characterized by paralysis of the recurrent laryngeal nerve. | Recurrent laryngeal nerve palsy |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms | Severe symptoms; medical intervention indicated (e.g., thyroplasty, vocal cord injection) | Life-threatening consequences; urgent intervention indicated | Death
10038359 |  | Renal and urinary disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate, local or noninvasive intervention indicated; limiting instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10038385 | A disorder characterized by the formation of crystals in the pelvis of the kidney. | Renal calculi |  | Asymptomatic or mild symptoms; occasional use of nonprescription analgesics indicated | Symptomatic; oral antiemetics indicated; around the clock nonprescription analgesics or any oral narcotic analgesics indicated | Hospitalization indicated; IV intervention (e.g., analgesics, antiemetics); elective endoscopic or radiologic intervention indicated | Life-threatening consequences; urgent radiologic, endoscopic or operative intervention indicated | Death
10038419 | A disorder characterized by paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of kidney stones. | Renal colic |  | Mild pain not interfering with activity; nonprescription medication indicated | Moderate pain; limiting instrumental ADL; prescription medication indicated | Hospitalization indicated; limiting self care ADL | - | -
10038463 | A disorder characterized by bleeding from the kidney. | Renal hemorrhage |  | Mild symptoms; intervention not indicated | Analgesics and hematocrit monitoring indicated | Transfusion, radiation, or hospitalization indicated; elective radiologic, endoscopic or operative intervention indicated | Life-threatening consequences; urgent radiologic or operative intervention indicated | Death
10038604 | - | Reproductive system and breast disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10038695 | A disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxemia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide. | Respiratory failure |  |  | - | - | Life-threatening consequences; urgent intervention, intubation, or ventilatory support indicated | Death
10038738 | - | Respiratory, thoracic and mediastinal disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10038743 | A disorder characterized by an inability to rest, relax or be still. | Restlessness |  | Mild symptoms; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10038748 | A disorder characterized by an inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and loses its flexibility. | Restrictive cardiomyopathy |  | - | - | Symptomatic heart failure or other cardiac symptoms, responsive to intervention | Refractory heart failure or other poorly controlled cardiac symptoms | Death
10038848 | A disorder characterized by the separation of the inner retina layers from the underlying pigment epithelium. | Retinal detachment |  | Asymptomatic | Exudative and visual acuity 20/40 or better | Rhegmatogenous or exudative detachment; operative intervention indicated; decline in vision (worse than 20/40 but better than 20/200) | Blindness (20/200 or worse) in the affected eye | -
10038897 | A disorder characterized by a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters. | Retinal tear |  | - | Laser therapy or pneumopexy indicated | Vitroretinal surgical repair indicated | Blindness (20/200 or worse) in the affected eye | -
10038901 | A disorder characterized by pathological retinal blood vessels that adversely affects vision. | Retinal vascular disorder |  | - | Topical medication indicated | Intravitreal medication; operative intervention indicated | - | -
10038921 | A disorder characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid. | Retinoic acid syndrome |  | Fluid retention; <3 kg of weight gain; intervention with fluid restriction and/or diuretics indicated | Moderate signs or symptoms; steroids indicated | Severe symptoms; hospitalization indicated | Life-threatening consequences; ventilatory support indicated | Death
10038923 | A disorder involving the retina. | Retinopathy |  | Asymptomatic; clinical or diagnostic observations only | Symptomatic with moderate decrease in visual acuity (20/40 or better); limiting instrumental ADL | Symptomatic with marked decrease in visual acuity (worse than 20/40); disabling; limiting self care ADL | Blindness (20/200 or worse) in the affected eye | -
10038981 | A disorder characterized by bleeding from the retroperitoneal area. | Retroperitoneal hemorrhage |  | - | Self-limited; intervention indicated | Transfusion, medical, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10039411 | A disorder characterized by an abnormal communication between a salivary gland and another organ or anatomic site. | [NAME] gland fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; tube feeding indicated | Severely altered GI function; hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10039413 | A disorder characterized by an infectious process involving the salivary gland. | [NAME] gland infection |  | - | Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10039722 | A disorder characterized by a malformed, lateral curvature of the spine. | Scoliosis |  | <20 degrees; clinically undetectable | >20 - 45 degrees; visible by forward flexion; limiting instrumental ADL | >45 degrees; scapular prominence in forward flexion; operative intervention indicated; limiting self care ADL; disabling | - | -
10039757 | A disorder characterized by marked discomfort sensation in the scrotal area. | Scrotal pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10039906 | A disorder characterized by a sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. | Seizure |  | Brief partial seizure; no loss of consciousness | Brief generalized seizure | Multiple seizures despite medical intervention | Life-threatening; prolonged repetitive seizures | Death
10040047 | A disorder characterized by the presence of pathogenic microorganisms in the blood stream that cause a rapidly progressing systemic reaction that may lead to shock. | Sepsis |  | - | - | - | Life-threatening consequences; urgent intervention indicated | Death
10040102 | A finding of tumor-like collection of serum in the tissues. | [NAME] |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; simple aspiration indicated | Symptomatic, elective radiologic or operative intervention indicated | - | -
10040139 | A finding based on laboratory test results that indicate an increase in the levels of amylase in a serum specimen. | Serum amylase increased |  | >ULN - 1.5 x ULN | >1.5 - 2.0 x ULN | >2.0 - 5.0 x ULN | >5.0 x ULN | -
10040400 | A disorder characterized by a delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty-one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest marked discomfort and dyspnea. | Serum sickness |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate arthralgia; fever, rash, urticaria, antihistamines indicated | Severe arthralgia or arthritis; extensive rash; steroids or IV fluids indicated | Life-threatening consequences; pressor or ventilatory support indicated | Death
10040639 | A disorder characterized by a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness. | Sick sinus syndrome |  | Asymptomatic, intervention not indicated | Non-urgent intervention indicated | Severe, medically significant; medical intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10040741 | A disorder characterized by a dysrhythmia with a heart rate less than 60 beats per minute that originates in the sinus node. | Sinus bradycardia |  | Asymptomatic, intervention not indicated | Symptomatic, medical intervention indicated | Severe, medically significant, medical intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10040747 | A disorder characterized by marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses. | Sinus pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10040752 | A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node. | Sinus tachycardia |  | Asymptomatic, intervention not indicated | Symptomatic; non-urgent medical intervention indicated | Urgent medical intervention indicated | - | -
10040753 | A disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses. | Sinusitis |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10040785 | - | Skin and subcutaneous tissue disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10040799 | A disorder characterized by the degeneration and thinning of the epidermis and dermis. | Skin atrophy |  | Covering <10% BSA; associated with telangiectasias or changes in skin color | Covering 10 - 30% BSA; associated with striae or [NAME] loss | Covering >30% BSA; associated with ulceration | - | -
10040865 | A disorder characterized by darkening of the skin due to excessive melanin deposition. | Skin hyperpigmentation |  | Hyperpigmentation covering <10% BSA; no psychosocial impact | Hyperpigmentation covering >10% BSA; associated psychosocial impact | - | - | -
10040868 | A disorder characterized by loss of skin pigment. | Skin hypopigmentation |  | Hypopigmentation or depigmentation covering <10% BSA; no psychosocial impact | Hypopigmentation or depigmentation covering >10% BSA; associated psychosocial impact | - | - | -
10040872 | A disorder characterized by an infectious process involving the skin. | Skin infection |  | Localized, local intervention indicated | Oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10040947 | A disorder characterized by circumscribed, inflammatory and necrotic erosive lesion on the skin. | Skin ulceration |  | Combined area of ulcers <1 cm; nonblanchable erythema of intact skin with associated warmth or edema | Combined area of ulcers 1 - 2 cm; partial thickness skin loss involving skin or subcutaneous fat | Combined area of ulcers >2 cm; full-thickness skin loss involving damage to or necrosis of subcutaneous tissue that may extend down to fascia | Any size ulcer with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures with or without full thickness skin loss | Death
10040975 | A disorder characterized by cessation of breathing for short periods during sleep. | Sleep apnea |  | Snoring and nocturnal sleep arousal without apneic periods | Moderate apnea and oxygen desaturation; excessive daytime sleepiness; medical evaluation indicated; limiting instrumental ADL | Oxygen desaturation; associated with hypertension; medical intervention indicated;  limiting self care ADL | Cardiovascular or neuropsychiatric symptoms; urgent operative intervention indicated | Death
10041101 | A disorder characterized by blockage of the normal flow of the intestinal contents. | Small intestinal obstruction |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Hospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10041103 | A disorder characterized by a rupture in the small intestine wall. | Small intestinal perforation |  | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10041133 | A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the small intestine. | Small intestine ulcer |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10041232 | A disorder characterized by the involuntary expulsion of air from the nose. | Sneezing |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | - | - | -
10041244 | - | Social circumstances - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10041349 | A disorder characterized by characterized by excessive sleepiness and drowsiness. | Somnolence |  | Mild but more than usual drowsiness or sleepiness | Moderate sedation; limiting instrumental ADL | Obtundation or stupor | Life-threatening consequences; urgent intervention indicated | Death
10041367 | A disorder characterized by of marked discomfort in the throat | Sore throat |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL; limiting ability to swallow | - | -
10041416 | A disorder characterized by increased involuntary muscle tone that affects the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances. | Spasticity |  | Mild or slight increase in muscle tone | Moderate increase in muscle tone and increase in resistance through range of motion | Severe increase in muscle tone and increase in resistance through range of motion | Life-threatening; unable to move active or passive range of motion | Death
10041569 | A finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken. | Spinal fracture |  | Mild back pain; nonprescription analgesics indicated | Moderate back pain; prescription analgesics indicated; limiting instrumental ADL | Severe back pain; hospitalization or intervention indicated for pain control (e.g., vertebroplasty); limiting self care ADL; disability | Life-threatening consequences; symptoms associated with neurovascular compromise | Death
10041633 | A disorder of the spleen. | Spleen disorder |  | Incidental findings (e.g., Howell-Jolly bodies); mild degree of thrombocytosis and leukocytosis | Prophylactic antibiotics indicated | - | Life-threatening consequences; urgent intervention indicated | Death
10042033 | A disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes. | [NAME] syndrome |  |  |  | Skin sloughing covering <10% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment) | Skin sloughing covering 10 - 30% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment) | Death
10042112 | A disorder characterized by a sensation of marked discomfort in the stomach. | Stomach pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10042127 | A disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the jejunal mucosal surface close to the anastomosis site following a gastroenterostomy procedure. | Stomal ulcer |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | - | -
10042241 | A disorder characterized by a high pitched breathing sound due to laryngeal or upper airway obstruction. | Stridor |  | - | - | Respiratory distress limiting self care ADL; medical intervention indicated | Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) | Death
10042244 | A disorder characterized by a sudden loss of sensory function due to an intracranial vascular event. | Stroke |  | Asymptomatic or mild neurologic deficit; radiographic findings only | Moderate neurologic deficit | Severe neurologic deficit | Life-threatening consequences; urgent intervention indicated | Death
10042435 | An unexpected cessation of life that cannot be attributed to a CTCAE term associated with Grade 5. | Sudden death NOS |  | - | - | - | - | Death
10042458 | A disorder characterized by thoughts of taking one's own life. | Suicidal ideation |  | Increased thoughts of death but no wish to kill oneself | Suicidal ideation with no specific plan or intent | Specific plan to commit suicide without serious intent to die which may not require hospitalization | Specific plan to commit suicide with serious intent to die which requires hospitalization | -
10042464 | A disorder characterized by self-inflicted harm in an attempt to end one's own life. | Suicide attempt |  | - | - | Suicide attempt or gesture without intent to die which may not require hospitalization | Suicide attempt with intent to die which requires hospitalization | Death
10042554 | A disorder characterized by a blood clot and inflammation involving a superficial vein of the extremities. | Superficial thrombophlebitis |  | - | Present | - | - | -
10042569 | A disorder characterized by obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache. | Superior vena cava syndrome |  | Asymptomatic; incidental finding of SVC thrombosis | Symptomatic; medical intervention indicated (e.g., anticoagulation, radiation or chemotherapy) | Severe symptoms; multi-modality intervention indicated  (e.g., anticoagulation, chemotherapy, radiation, stenting) | Life-threatening consequences; urgent multi-modality intervention indicated (e.g., lysis, thrombectomy, surgery) | Death
10042604 | A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates above the ventricles. | Supraventricular tachycardia |  | Asymptomatic, intervention not indicated | Non-urgent medical intervention indicated | Medical intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10042613 | - | Surgical and medical procedures - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10042772 | A disorder characterized by spontaneous loss of consciousness caused by insufficient blood supply to the brain. | Syncope |  | - | - | Fainting; orthostatic collapse | - | -
10043189 | A disorder characterized by local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes. | Telangiectasia |  | Telangiectasias covering <10% BSA | Telangiectasias covering >10% BSA; associated with psychosocial impact | - | - | -
10043306 | A disorder characterized by involvement of the testis. | Testicular disorder |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic but not interfering with urination or sexual activities; intervention not indicated; limiting instrumental ADL | Severe symptoms; interfering with urination or sexual function; limiting self care ADL; intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10043345 | A disorder characterized by a sensation of marked discomfort in the testis. | Testicular pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10043565 | A disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream. | Thromboembolic event |  | Venous thrombosis (e.g., superficial thrombosis) | Venous thrombosis (e.g., uncomplicated deep vein thrombosis), medical intervention indicated | Thrombosis (e.g., uncomplicated pulmonary embolism [venous], non-embolic cardiac mural [arterial] thrombus), medical intervention indicated | Life-threatening (e.g., pulmonary embolism, cerebrovascular event, arterial insufficiency); hemodynamic or neurologic instability; urgent intervention indicated | Death
10043648 | A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition. | Thrombotic thrombocytopenic purpura |  | Evidence of RBC destruction (schistocytosis) without clinical consequences | - | Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae) | Life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure) | Death
10043882 | A disorder characterized by noise in the ears, such as ringing, buzzing, roaring or clicking. | Tinnitus |  | Mild symptoms; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10044030 | A disorder characterized by a pathological process of the teeth occurring during tooth development. | Tooth development disorder |  | Asymptomatic; [NAME] of tooth or enamel | Impairment correctable with oral surgery | Maldevelopment with impairment not surgically correctable; disabling | - | -
10044031 | A disorder characterized by a change in tooth hue or tint. | Tooth discoloration |  | Surface stains | - | - | - | -
10044055 | A disorder characterized by a sensation of marked discomfort in the tooth. | Toothache |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10044223 | A disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes. | Toxic epidermal necrolysis |  | - | - | - | Skin sloughing covering >=30% BSA with associated symptoms (e.g., erythema, purpura, or epidermal detachment) | Death
10044291 | A finding of blockage of the lumen of the trachea. | Tracheal obstruction |  | Partial asymptomatic obstruction on examination (e.g., visual, radiologic or endoscopic) | Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL | Stridor; radiologic or endoscopic intervention indicated (e.g., stent, laser); limiting self care ADL | Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) | Death
10044302 | A disorder characterized by an infectious process involving the trachea. | Tracheitis |  | - | Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10044391 | A disorder characterized by a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit. | Transient ischemic attacks |  | Mild neurologic deficit with or without imaging confirmation | Moderate neurologic deficit with or without imaging confirmation | - | - | -
10044565 | A disorder characterized by the uncontrolled shaking movement of the whole body or individual parts. | Tremor |  | Mild symptoms | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10044684 | A disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication. | Trismus |  | Decreased ROM (range of motion) without impaired eating | Decreased ROM requiring small bites, soft foods or purees | Decreased ROM with inability to adequately aliment or hydrate orally | - | -
10045152 | A disorder characterized by metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. | Tumor lysis syndrome |  | - | - | Present | Life-threatening consequences; urgent intervention indicated | Death
10045158 | A disorder characterized by marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis. | Tumor pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10045271 | A disorder characterized by inflammation of the cecum. | Typhlitis |  | - | - | Symptomatic (e.g., abdominal pain, fever, change in bowel habits with ileus); peritoneal signs | Life-threatening consequences; urgent operative intervention indicated | Death
10045542 | A disorder characterized by an unexpected pregnancy at the time of conception. | Unintended pregnancy |  | - | - | Unintended pregnancy | - | -
10046300 | A disorder characterized by an infectious process involving the upper respiratory tract (nose, paranasal sinuses, pharynx, [NAME], or trachea). | Upper respiratory infection |  | - | Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10046539 | A disorder characterized by urination at short intervals. | Urinary frequency |  | Present | Limiting instrumental ADL; medical management indicated | - | - | -
10046543 | A disorder characterized by inability to control the flow of urine from the bladder. | Urinary incontinence |  | Occasional (e.g., with coughing, sneezing, etc.), pads not indicated | Spontaneous; pads indicated; limiting instrumental ADL | Intervention indicated (e.g., clamp, collagen injections); operative intervention indicated; limiting self care ADL | - | -
10046555 | A disorder characterized by accumulation of urine within the bladder because of the inability to urinate. | Urinary retention |  | Urinary, suprapubic or intermittent catheter placement not indicated; able to void with some residual | Placement of urinary, suprapubic or intermittent catheter placement indicated; medication indicated | Elective operative or radiologic intervention indicated; substantial loss of affected kidney function or mass | Life-threatening consequences; organ failure; urgent operative intervention indicated | Death
10046571 | A disorder characterized by an infectious process involving the urinary tract, most commonly the bladder and the urethra. | Urinary tract infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10046593 | A disorder characterized by a sudden compelling urge to urinate. | Urinary urgency |  | Present | Limiting instrumental ADL; medical management indicated | - | - | -
10046628 | A disorder characterized by a change in the color of the urine. | [NAME] discoloration |  | Present | - | - | - | -
10046735 | A disorder characterized by an itchy skin eruption characterized by wheals with pale interiors and well-defined red margins. | Urticaria |  | Urticarial lesions covering <10% BSA; topical intervention indicated | Urticarial lesions covering 10 - 30% BSA; oral intervention indicated | Urticarial lesions covering >30% BSA; IV intervention indicated | - | -
10046789 | A disorder characterized by bleeding from the uterus. | Uterine hemorrhage |  | Minimal bleeding identified on imaging study; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10046809 | A disorder characterized by a sensation of marked discomfort in the uterus. | Uterine pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10046810 | A disorder characterized by a rupture in the uterine wall. | Uterine perforation |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10046851 | A disorder characterized by inflammation to the uvea of the eye. | Uveitis |  | Asymptomatic; clinical or diagnostic observations only | Anterior uveitis; medical intervention indicated | Posterior or pan-uveitis | Blindness (20/200 or worse) in the affected eye | -
10046901 | A disorder characterized by vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. | Vaginal discharge |  | Mild vaginal discharge (greater than baseline for patient) | Moderate to heavy vaginal discharge; use of perineal pad or tampon indicated | - | - | -
10046904 | A disorder characterized by an uncomfortable feeling of itching and burning in the vagina. | Vaginal dryness |  | Mild vaginal dryness not interfering with sexual function | Moderate vaginal dryness interfering with sexual function or causing frequent discomfort | Severe vaginal dryness resulting in dyspareunia or severe discomfort | - | -
10046912 | A disorder characterized by bleeding from the vagina. | Vaginal hemorrhage |  | Minimal bleeding identified on clinical exam or imaging study; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10046914 | A disorder characterized by an infectious process involving the vagina. | Vaginal infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10046916 | A disorder characterized by inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge. | Vaginal inflammation |  | Mild discomfort or pain, edema, or redness | Moderate discomfort or pain, edema, or redness; limiting instrumental ADL | Severe discomfort or pain, edema, or redness; limiting self care ADL; small areas of mucosal ulceration | Widespread areas of mucosal ulceration; life-threatening consequences; urgent intervention indicated | Death
10046937 | A disorder characterized by a sensation of marked discomfort in the vagina. | Vaginal pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10046947 | A disorder characterized by involuntary spasms of the pelvic floor muscles, resulting in pathologic tightness of the vaginal wall during penetration such as during sexual intercourse. | Vaginismus |  | Mild discomfort or pain associated with vaginal spasm/tightening; no impact upon sexual function or physical examination | Moderate discomfort or pain associated with vaginal spasm/tightening; disruption in sexual function and physical examination | Severe discomfort or pain associated with vaginal spasm/tightening; unable to tolerate vaginal penetration or physical examination | - | -
10047065 | - | Vascular disorders - Other, specify |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling;  limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10047115 | A disorder characterized by inflammation involving the wall of a vessel. | Vasculitis |  | Asymptomatic, intervention not indicated | Moderate symptoms, medical intervention indicated | Severe symptoms, medical intervention indicated (e.g., steroids) | Life-threatening; evidence of peripheral or visceral ischemia; urgent intervention indicated | Death
10047166 | A disorder characterized by a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve. | Vasovagal reaction |  | - | - | Present | Life-threatening consequences; urgent intervention indicated | Death
10047228 | A finding of damage to a vein. | Venous injury |  | Asymptomatic diagnostic finding; intervention not indicated | Symptomatic (e.g., claudication); repair or revision not indicated | Severe symptoms; limiting self care ADL; repair or revision indicated; disabling | Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated | Death
10047281 | A disorder characterized by a dysrhythmia that originates in the ventricles. | Ventricular arrhythmia |  | Asymptomatic, intervention not indicated | Non-urgent medical intervention indicated | Medical intervention indicated | Life-threatening consequences; hemodynamic compromise; urgent intervention indicated | Death
10047290 | A disorder characterized by a dysrhythmia without discernible QRS complexes due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricles. | Ventricular fibrillation |  | - | - | - | Life-threatening consequences; hemodynamic compromise; urgent intervention indicated | Death
10047302 | A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates distal to the bundle of His. | Ventricular tachycardia |  | - | Non-urgent medical intervention indicated | Medical intervention indicated | Life-threatening consequences; hemodynamic compromise; urgent intervention indicated | Death
10047340 | A disorder characterized by a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo). | Vertigo |  | Mild symptoms | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10047386 | A disorder characterized by dizziness, imbalance, nausea, and vision problems. | Vestibular disorder |  | - | Symptomatic; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10047488 | A disorder characterized by inappropriate masculinization occurring in a female or prepubertal male. | Virilization |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | - | - | -
10047580 | A finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value. | Vital capacity abnormal |  | 90 - 75% of predicted value | <75 - 50% of predicted value; limiting instrumental ADL | <50% of predicted value; limiting self care ADL | - | -
10047656 | A disorder characterized by blood extravasation into the vitreous humor. | Vitreous hemorrhage |  | Asymptomatic or mild symptoms; clinical or diagnostic observations only | Symptomatic; limiting instrumental ADL | Limiting self care ADL; vitrectomy indicated | Blindness (20/200 or worse) in the affected eye | -
10047681 | A disorder characterized by a change in the sound and/or speed of the voice. | Voice alteration |  | Mild or intermittent change from normal voice | Moderate or persistent change from normal voice; still understandable | Severe voice changes including predominantly whispered speech; may require frequent repetition or face-to-face contact for understandability; may require assistive technology | - | -
10047700 | A disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth. | Vomiting |  | 1 - 2 episodes (separated by 5 minutes) in 24 hrs | 3 - 5 episodes (separated by 5 minutes) in 24 hrs | >=6 episodes (separated by 5 minutes) in 24 hrs; tube feeding, [NAME] or hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death
10047848 | A disorder of excessive tearing in the eyes; it can be caused by overproduction of tears or impaired drainage of the tear duct. | Watering eyes |  | Intervention not indicated | Intervention indicated | Operative intervention indicated | - | -
10047896 | A finding characterized by an increase in overall body weight; for pediatrics, greater than the baseline growth curve. | Weight gain |  | 5 - <10% from baseline | 10 - <20% from baseline | >=20% from baseline | - | -
10047900 | A finding characterized by a decrease in overall body weight; for pediatrics, less than the baseline growth curve. | Weight loss |  | 5 to <10% from baseline; intervention not indicated | 10 - <20% from baseline; nutritional support indicated | >=20% from baseline; tube feeding or TPN indicated | - | -
10047924 | A disorder characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways. | [NAME] |  | Detectable airway noise with minimal symptoms | Moderate symptoms; medical intervention indicated; limiting instrumental ADL | Severe respiratory symptoms limiting self care ADL; oxygen therapy or hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death
10048015 | A disorder characterized by the presence of an accessory conductive pathway between the atria and the ventricles that causes premature ventricular activation. | Wolff-Parkinson-White syndrome |  | Asymptomatic, intervention not indicated | Non-urgent medical intervention indicated | Symptomatic and incompletely controlled medically or controlled with procedure | Life-threatening consequences; urgent intervention indicated | Death
10048031 | A finding of separation of the approximated margins of a surgical wound. | Wound dehiscence |  | Incisional separation of <=25% of wound, no deeper than superficial fascia | Incisional separation >25% of wound with local care; asymptomatic hernia or symptomatic hernia without evidence of strangulation | Fascial disruption or dehiscence without evisceration; primary wound closure or revision by operative intervention indicated | Life-threatening consequences; symptomatic hernia with evidence of strangulation; fascial disruption with evisceration; major reconstruction flap, grafting, resection, or amputation indicated | Death
10048038 | A disorder characterized by an infectious process involving the wound. | Wound infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10048049 | A finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken. | Wrist fracture |  | Mild; non-surgical intervention indicated | Limiting instrumental ADL; operative intervention indicated | Limiting self care ADL; elective surgery indicated | - | -
10048293 | A disorder characterized by leukemia arising as a result of the mutagenic effect of chemotherapy agents. | Leukemia secondary to oncology chemotherapy |  | - | - | - | Present | Death
10048492 | A disorder characterized by an area of epithelial tissue loss on the surface of the cornea. It is associated with inflammatory cells in the cornea and anterior chamber. | Corneal ulcer |  | - | Symptomatic; medical intervention indicated (e.g., topical agents); limiting instrumental ADL | Limiting self care ADL; declining vision (worse than 20/40 but better than 20/200) | Perforation or blindness (20/200 or worse) in the affected eye | -
10048580 | A disorder characterized by the inability of the bone marrow to produce hematopoietic elements. | Bone marrow hypocellular |  | Mildly hypocellular or <=25% reduction from normal cellularity for age | Moderately hypocellular or >25 - <50% reduction from normal cellularity for age | Severely hypocellular or >50 - <=75% reduction cellularity from normal for age | Aplastic persistent for longer than 2 weeks | Death
10048642 | A disorder characterized by a cystic lesion containing lymph. | Lymphocele |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | - | -
10048677 | A disorder characterized by marked discomfort sensation in the buttocks. | Buttock pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10048706 | A disorder characterized by a decrease in joint flexibility of any joint. | Joint range of motion decreased |  | <=25% loss of ROM (range of motion); decreased ROM limiting athletic activity | >25 - 50% decrease in ROM; limiting instrumental ADL | >50% decrease in ROM; limiting self care ADL; disabling | - | -
10048762 | A disorder characterized by an infectious process involving a tooth. | Tooth infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10048994 | A disorder characterized by a sudden and involuntary contraction of the bladder wall. | Bladder spasm |  | Intervention not indicated | Antispasmodics indicated | Hospitalization indicated | - | -
10049120 | A disorder characterized by marked discomfort sensation in the skin covering the top and the back of the head. | Scalp pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10049182 | A finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen. | White blood cell decreased |  | <LLN - 3000/mm3; <LLN - 3.0 x 10e9 /L | <3000 - 2000/mm3; <3.0 - 2.0 x 10e9 /L | <2000 - 1000/mm3; <2.0 - 1.0 x 10e9 /L | <1000/mm3; <1.0 x 10e9 /L | -
10049192 | A disorder characterized by an abnormal communication between the pancreas and another organ or anatomic site. | Pancreatic fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding or [NAME] or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10049281 | A disorder characterized by loss of all or a portion of the nail. | Nail loss |  | Asymptomatic separation of the nail bed from the nail plate or nail loss | Symptomatic separation of the nail bed from the nail plate or nail loss; limiting instrumental ADL | - | - | -
10049468 | A finding of blood leakage from the intestinal stoma. | Intestinal stoma site bleeding |  | Minimal bleeding identified on clinical exam; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10049737 | A disorder characterized by development of a malignancy most probably as a result of treatment for a previously existing malignancy. | Treatment related secondary malignancy |  | - | - | Non life-threatening secondary malignancy | Acute life-threatening secondary malignancy; blast crisis in leukemia | Death
10050028 | A disorder characterized by a narrowing of the pharyngeal airway. | Pharyngeal stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL | Limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) | Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) | Death
10050068 | A disorder characterized by swelling due to excessive fluid accumulation in the upper or lower extremities. | Edema limbs |  | 5 - 10% inter-limb discrepancy in volume or circumference at point of greatest visible difference; swelling or obscuration of anatomic architecture on close inspection | >10 - 30% inter-limb discrepancy in volume or circumference at point of greatest visible difference; readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental ADL | >30% inter-limb discrepancy in volume; gross deviation from normal anatomic contour; limiting self care ADL | - | -
10050094 | A disorder characterized by a narrowing of the lumen of the duodenum. | Duodenal stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10050457 | A finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures). | Pancreatic anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10050458 | A finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures). | Biliary anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10050528 | The percentage computed when the amount of blood ejected during a ventricular contraction of the heart is compared to the amount that was present prior to the contraction. | Ejection fraction decreased |  | - | Resting ejection fraction (EF) 50 - 40%; 10 - 19% drop from baseline | Resting ejection fraction (EF) 39 - 20%; >20% drop from baseline | Resting ejection fraction (EF) <20% | -
10050662 | A disorder characterized by an infectious process involving the prostate gland. | Prostate infection |  | - | Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10050816 | A disorder characterized by a narrowing of the trachea. | Tracheal stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids) | Stridor or respiratory distress limiting self care ADL; endoscopic intervention indicated (e.g., stent, laser) | Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) | Death
10050823 | A disorder characterized by an infectious process involving the lymph nodes. | Lymph gland infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10051228 | A disorder characterized by milky pleural effusion (abnormal collection of fluid) resulting from accumulation of lymph fluid in the pleural cavity. | [NAME] |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; thoracentesis or tube drainage indicated | Severe symptoms; elective operative intervention indicated | Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated | Death
10051272 | A disorder characterized by a reduction in the strength of the facial muscles. | Facial muscle weakness |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10051341 | A disorder characterized by a narrowing of the lumen of the bile duct. | Bile duct stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; IV fluids indicated <24 hrs | Severely altered GI function; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10051472 | A disorder characterized by an infectious process involving the orbit of the eye. | Periorbital infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10051592 | A disorder characterized by signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction. | Acute coronary syndrome |  | - | Symptomatic, progressive angina; cardiac enzymes normal; hemodynamically stable | Symptomatic, unstable angina and/or acute myocardial infarction, cardiac enzymes abnormal, hemodynamically stable | Symptomatic, unstable angina and/or acute myocardial infarction, cardiac enzymes abnormal, hemodynamically unstable | Death
10051741 | A disorder characterized by an infectious process involving the pancreas. | Pancreas infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10051746 | A disorder characterized by bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus). | Lower gastrointestinal hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10051792 | A disorder characterized by adverse reaction to the infusion of pharmacological or biological substances. | Infusion related reaction |  | Mild transient reaction; infusion interruption not indicated; intervention not indicated | Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24 hrs | Prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae | Life-threatening consequences; urgent intervention indicated | Death
10051837 | A disorder characterized by an area of hardness in the skin. | Skin induration |  | Mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) | Moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL | Severe induration, unable to slide or pinch skin; limiting joint movement or orifice (e.g., mouth, anus); limiting self care ADL | Generalized; associated with signs or symptoms of impaired breathing or feeding | Death
10051886 | A disorder characterized by a necrotic process occurring in the gastric wall. | Gastric necrosis |  | - | - | Inability to aliment adequately by GI tract; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10052015 | A disorder characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath; it is caused by the release of cytokines from the cells. | Cytokine release syndrome |  | Mild reaction; infusion interruption not indicated; intervention not indicated | Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24 hrs | Prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates) | Life-threatening consequences; pressor or ventilatory support indicated | Death
10052298 | A disorder characterized by an infectious process involving the urethra. | Urethral infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10052426 | A disorder characterized by an inability to properly metabolize glucose. | Glucose intolerance |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; dietary modification or oral agent indicated | Severe symptoms; insulin indicated | Life-threatening consequences; urgent intervention indicated | Death
10053481 | A disorder characterized by an abnormal communication between a bronchus and the pleural cavity. | Bronchopleural fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) | Life-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated | Death
10053496 | A disorder characterized by a narrowing of the vaginal canal. | Vaginal stricture |  | Asymptomatic; mild vaginal shortening or narrowing | Vaginal narrowing and/or shortening not interfering with physical examination | Vaginal narrowing and/or shortening interfering with the use of tampons, sexual activity or physical examination | - | Death
10053565 | A disorder characterized by an increase in intrapericardial pressure due to the collection of blood or fluid in the pericardium. | Pericardial tamponade |  | - | - | - | Life-threatening consequences; urgent intervention indicated | Death
10053661 | A disorder characterized by involvement of the oculomotor nerve (third cranial nerve). | Oculomotor nerve disorder |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10053662 | A disorder characterized by involvement of the abducens nerve (sixth cranial nerve). | Abducens nerve disorder |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10053692 | A finding of development of a new problem at the site of an existing wound. | Wound complication |  | Incisional separation of <=25% of wound, no deeper than superficial fascia | Incisional separation >25% of wound; local care indicated | Hernia without evidence of strangulation; fascial disruption/dehiscence; primary wound closure or revision by operative intervention indicated | Hernia with evidence of strangulation; major reconstruction flap, grafting, resection, or amputation indicated | Death
10054382 | A disorder characterized by the development of secondary female sex characteristics in males due to extrinsic factors. | Feminization acquired |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | - | - | -
10054482 | A disorder characterized by swelling due to an accumulation of excessive fluid in the neck. | Neck edema |  | Asymptomatic localized neck edema | Moderate neck edema; slight obliteration of anatomic landmarks; limiting instrumental ADL | Generalized neck edema (e.g., difficulty in turning neck); limiting self care ADL | - | -
10054520 | A disorder characterized by a burning or tingling sensation on the lips, tongue or entire mouth. | Oral dysesthesia |  | Mild discomfort; not interfering with oral intake | Moderate pain; interfering with oral intake | Disabling pain; tube feeding or TPN indicated | - | -
10054524 | A disorder characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet. | Palmar-plantar erythrodysesthesia syndrome |  | Minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain | Skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental ADL | Severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self care ADL | - | -
10054541 | A disorder characterized by swelling due to an excessive accumulation of fluid around the orbits of the face. | Periorbital edema |  | Soft or non-pitting | Indurated or pitting edema; topical intervention indicated | Edema associated with visual disturbance; increased intraocular pressure, glaucoma or retinal hemorrhage; optic neuritis; diuretics indicated; operative intervention indicated | - | -
10054692 | A disorder characterized by a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery. | Visceral arterial ischemia |  | - | Brief (<24 hrs) episode of ischemia managed medically and without permanent deficit | Prolonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated | Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated | Death
10054746 | A disorder characterized by inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight. | Fetal growth retardation |  | - | <10% percentile of weight for gestational age | <5% percentile of weight for gestational age | <1% percentile of weight for gestational age | -
10055005 | A disorder characterized by an infectious process involving the ovary. | Ovarian infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10055026 | A disorder characterized by compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder). | Prostatic obstruction |  | Diagnostic observations only; intervention not indicated | Mild symptoms; elective intervention indicated | Severe symptoms; elective operative intervention indicated | - | -
10055078 | A disorder characterized by an infectious process involving the bronchi. | Bronchial infection |  | - | Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10055226 | A disorder characterized by bleeding from the anal region. | Anal hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10055242 | A disorder characterized by bleeding from the duodenum. | Duodenal hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10055287 | A disorder characterized by bleeding from the ileal wall. | Ileal hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10055291 | A disorder characterized by bleeding in the abdominal cavity. | Intra-abdominal hemorrhage |  | - | Medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10055298 | A finding of uncontrolled bleeding during a surgical procedure. | Intraoperative hemorrhage |  | - | - | Postoperative radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10055300 | A disorder characterized by bleeding from the jejunal wall. | Jejunal hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10055315 | A disorder characterized by bleeding from the pharynx. | Pharyngeal hemorrhage |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | Transfusion, radiologic, endoscopic, or operative intervention indicated (e.g., hemostasis of bleeding site) | Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated | Death
10055319 | A disorder characterized by bleeding from the pleural cavity. | Pleural hemorrhage |  | Asymptomatic; mild hemorrhage confirmed by thoracentesis | Symptomatic or associated with pneumothorax; chest tube drainage indicated | >1000 ml of blood evacuated; persistent bleeding (150-200 ml/hr for 2 - 4 hr); persistent transfusion indicated; elective operative intervention indicated | Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated | Death
10055322 | A finding of bleeding occurring after a surgical procedure. | Postoperative hemorrhage |  | Minimal bleeding identified on clinical exam; intervention not indicated | Moderate bleeding; radiologic, endoscopic, or operative intervention indicated | Transfusion indicated of >=2 units (10 cc/kg for pediatrics) pRBCs beyond protocol specification; urgent radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10055325 | A disorder characterized by bleeding from the prostate gland. | Prostatic hemorrhage |  | Minimal bleeding identified on imaging study; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10055347 | A disorder characterized by bleeding from the testis. | Testicular hemorrhage |  | Minimal bleeding identified on imaging study; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10055356 | A disorder characterized by bleeding from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach). | Upper gastrointestinal hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10055472 | A disorder characterized by a rupture in the wall of the esophagus. | Esophageal perforation |  | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10055599 | A finding based on laboratory test results that indicate increased levels of hemoglobin in a biological specimen. | Hemoglobin increased |  | Increase in >0 - 2 gm/dL above ULN or above baseline if baseline is above ULN | Increase in >2 - 4 gm/dL above ULN or above baseline if baseline is above ULN | Increase in >4 gm/dL above ULN or above baseline if baseline is above ULN | - | -
10056238 | A disorder characterized by marked discomfort related to a limb or an organ that is removed from or is not physically part of the body. | Phantom pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10056356 | A disorder characterized by bleeding from the mediastinum. | Mediastinal hemorrhage |  | Radiologic evidence only; minimal symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated (e.g., hemostasis of bleeding site) | Life-threatening consequences; urgent intervention indicated | Death
10056388 | A disorder characterized by involvement of the olfactory nerve (first cranial nerve). | Olfactory nerve disorder |  | - | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10056519 | A disorder characterized by an infectious process involving the abdominal cavity. | Abdominal infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10056522 | A disorder characterized by an infectious process involving the liver. | Hepatic infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10056627 | A disorder characterized by an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein. | Phlebitis infective |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10056681 | A disorder characterized by inflammation of the salivary duct. | [NAME] duct inflammation |  | Slightly thickened saliva; slightly altered taste (e.g., metallic) | Thick, ropy, sticky saliva; markedly altered taste; alteration in diet indicated; secretion-induced symptoms; limiting instrumental ADL | Acute salivary gland necrosis; severe secretion-induced symptoms (e.g., [NAME]/oral secretions or gagging);  tube feeding or TPN indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent intervention indicated | Death
10056745 | A finding of a previously undocumented problem that occurs after a thoracic procedure. | Postoperative thoracic procedure complication |  | - | Extubated within 24 - 72 hrs postoperatively | Extubated >72 hrs postoperatively, but before tracheostomy indicated | Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) | Death
10056910 | A finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water. | GGT increased |  | >ULN - 2.5 x ULN | >2.5 - 5.0 x ULN | >5.0 - 20.0 x ULN | >20.0 x ULN | -
10057066 | A disorder characterized by sexual dysfunction characterized by a delay in climax. | Delayed orgasm |  | Delay in achieving orgasm not adversely affecting relationship | Delay in achieving orgasm adversely affecting relationship | - | - | -
10057262 | A disorder characterized by an infectious process involving the peritoneum. | Peritoneal infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10057483 | A disorder characterized by an infectious process involving the mediastinum. | Mediastinal infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10058084 | A disorder characterized by unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys. | Precocious puberty |  | Physical signs of puberty with no biochemical markers for females <8 years and males <9 years | Physical signs and biochemical markers of puberty for females <8 years and males <9 years | - | - | -
10058096 | A disorder characterized by a necrotic process occurring in the pancreas. | Pancreatic necrosis |  | - | - | Tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10058597 | A disorder characterized by impairment of right ventricular function associated with low ejection fraction and a decrease in motility of the right ventricular wall. | Right ventricular dysfunction |  | Asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities | Symptoms with mild to moderate activity or exertion | Severe symptoms, associated with hypoxemia, right heart failure; oxygen indicated | Life-threatening consequences; urgent intervention indicated (e.g., ventricular assist device); heart transplant indicated | Death
10058674 | A disorder characterized by an infectious process involving the pelvic cavity. | Pelvic infection |  | - | Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10058720 | A disorder characterized by swelling due to excessive fluid accumulation in the trunk area. | Edema trunk |  | Swelling or obscuration of anatomic architecture on close inspection | Readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental ADL | Gross deviation from normal anatomic contour; limiting self care ADL | - | -
10058804 | A disorder characterized by an infectious process involving the esophagus. | Esophageal infection |  | - | Local intervention indicated (e.g., oral antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10058838 | A disorder characterized by an infectious process involving the small and large intestines. | Enterocolitis infectious |  | - | Passage of >3 unformed stools per 24 hrs or duration of illness >48 hrs; moderate abdominal pain | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated; profuse watery diarrhea with signs of hypovolemia;  bloody diarrhea; fever; severe abdominal pain; hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death
10059094 | A finding of blockage of the normal flow of the contents of the intestinal stoma. | Intestinal stoma obstruction |  |  | Self-limited; intervention not indicated | Severe symptoms; IV fluids, tube feeding, or TPN indicated >=24 hrs; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10059095 | A finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body). | Intestinal stoma leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10059446 | A disorder characterized by a necrotic process occurring in the gallbladder. | Gallbladder necrosis |  | - | - | - | Life-threatening consequences; urgent radiologic or operative intervention indicated | Death
10059639 | A disorder characterized by blockage of the laryngeal airway. | Laryngeal obstruction |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL | Limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) | Life-threatening consequences; urgent intervention indicated | Death
10059827 | A disorder characterized by an infectious process involving the nasal mucosal. | Rhinitis infective |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | - | - | -
10059895 | A finding based on test results that indicate urine production is less relative to previous output. | [NAME] output decreased |  | - | - | Oliguria (<80 ml in 8 hr) | Anuria (<240 ml in 24 hr) | -
10060602 | A disorder characterized by the presence of blood in a fallopian tube. | Hematosalpinx |  | Minimal bleeding identified on imaging study or laparoscopy; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10060640 | A disorder characterized by bleeding from the hemorrhoids. | Hemorrhoidal hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10060890 | A disorder characterized by involvement of the trigeminal nerve (fifth cranial nerve). | Trigeminal nerve disorder |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10060929 | A disorder characterized by involvement of the accessory nerve (eleventh cranial nerve). | Accessory nerve disorder |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10061017 | A disorder characterized by an infectious process involving the bones. | Bone infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10061103 | A finding of cutaneous inflammatory reaction occurring as a result of exposure to biologically effective levels of ionizing radiation. | Dermatitis radiation |  | Faint erythema or dry desquamation | Moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema | Moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion | Life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated | Death
10061145 | A disorder characterized by impaired eyelid function. | Eyelid function disorder |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; nonoperative intervention indicated; limiting instrumental ADL | Limiting self care ADL; operative intervention indicated | - | -
10061149 | A disorder characterized by an abnormal communication between a female reproductive system organ and another organ or anatomic site. | Female genital tract fistula |  | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10061185 | A disorder characterized by involvement of the glossopharyngeal nerve (ninth cranial nerve). | Glossopharyngeal nerve disorder |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10061212 | A disorder characterized by involvement of the hypoglossal nerve (twelfth cranial nerve). | Hypoglossal nerve disorder |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10061229 | A disorder characterized by an infectious process involving the lungs. | Lung infection |  | - | Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10061261 | A disorder characterized by disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males. | Lactation disorder |  | Mild changes in lactation, not significantly affecting production or expression of breast milk | Changes in lactation, significantly affecting breast production or expression of breast milk | - | - | -
10061304 | A disorder characterized by an infectious process involving the nail. | Nail infection |  | Localized, local intervention indicated | Oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | - | -
10061322 | A disorder characterized by involvement of the optic nerve (second cranial nerve). | Optic nerve disorder |  | Asymptomatic; clinical or diagnostic observations only | Limiting vision of the affected eye (20/40 or better) | Limiting vision in the affected eye (worse than 20/40 but better than 20/200) | Blindness (20/200 or worse) in the affected eye | -
10061339 | A disorder characterized by a sensation of marked discomfort in the area between the genital organs and the anus. | Perineal pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10061351 | A disorder characterized by an infectious process involving the pleura. | Pleural infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10061389 | A disorder characterized by a defect in tricuspid valve function or structure. | Tricuspid valve disease |  | Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis | Asymptomatic; moderate regurgitation or stenosis by imaging | Symptomatic; severe regurgitation or stenosis; symptoms controlled with medical intervention | Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) | Death
10061403 | A disorder characterized by involvement of the vagus nerve (tenth cranial nerve). | Vagus nerve disorder |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10061457 | A disorder characterized by involvement of the facial nerve (seventh cranial nerve). | Facial nerve disorder |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10061461 | A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity. | Erectile dysfunction |  | Decrease in erectile function (frequency or rigidity of erections) but intervention not indicated (e.g., medication or use of mechanical device, penile pump) | Decrease in erectile function (frequency/rigidity of erections), erectile intervention indicated, (e.g., medication or mechanical devices such as penile pump) | Decrease in erectile function (frequency/rigidity of erections) but erectile intervention not helpful (e.g., medication or mechanical devices such as penile pump); placement of a permanent penile prosthesis indicated (not previously present) | - | -
10061510 | A disorder characterized by involvement of the sclera of the eye. | Scleral disorder |  | Asymptomatic; clinical or diagnostic observations only | Symptomatic, limiting instrumental ADL; moderate decrease in visual acuity (20/40 or better) | Symptomatic, limiting self care ADL; marked decrease in visual acuity (worse than 20/40) | Blindness (20/200 or worse) in the affected eye | -
10061532 | A disorder characterized by a defect in mitral valve function or structure. | Mitral valve disease |  | Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging | Asymptomatic; moderate regurgitation or stenosis by imaging | Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention | Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) | Death
10061541 | A disorder characterized by a defect in pulmonary valve function or structure. | [NAME] valve disease |  | Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging | Asymptomatic; moderate regurgitation or stenosis by imaging | Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention | Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) | Death
10061574 | A disorder characterized by blockage of the normal flow of contents of the urinary tract. | Urinary tract obstruction |  | Asymptomatic; clinical or diagnostic observations only | Symptomatic but no hydronephrosis, sepsis or renal dysfunction; urethral dilation, urinary or suprapubic catheter indicated | Symptomatic and altered organ function (e.g., hydronephrosis, or renal dysfunction); elective radiologic, endoscopic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10061589 | A disorder characterized by a defect in aortic valve function or structure. | Aortic valve disease |  | Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging | Asymptomatic; moderate regurgitation or stenosis by imaging | Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention | Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) | Death
10061640 | A disorder characterized by an infectious process involving the anal area and the rectum. | Anorectal infection |  | Localized; local intervention indicated | Oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10061664 | A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents. | Autoimmune disorder |  | Asymptomatic; serologic or other evidence of autoimmune reaction, with normal organ function;  intervention not indicated | Evidence of autoimmune reaction involving a non-essential organ or function (e.g., hypothyroidism) | Autoimmune reactions involving major organ (e.g., colitis, anemia, myocarditis, kidney) | Life-threatening consequences; urgent intervention indicated | Death
10061695 | A disorder characterized by an infectious process involving the biliary tract. | Biliary tract infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10061788 | A disorder characterized by an infectious process involving the cornea. | Corneal infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10061912 | A disorder characterized by an infectious process involving the penis. | Penile infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10061928 | A disorder characterized by inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root. | Radiculitis |  | Mild symptoms | Moderate symptoms; limiting instrumental ADL; medical intervention indicated | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10061970 | A disorder characterized by a narrowing of the lumen of the stomach. | Gastric stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10062112 | A disorder characterized by an infectious process involving the spleen. | Splenic infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10062156 | A disorder characterized by an infectious process involving the scrotum. | Scrotal infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10062169 | A finding of a previously undocumented problem related to the vascular access site. | Vascular access complication |  | - | Device dislodgement, blockage, leak, or malposition; device replacement indicated | Deep vein or cardiac thrombosis; intervention indicated (e.g., anticoagulation, lysis, filter, invasive procedure) | Embolic event including pulmonary embolism or life-threatening thrombus | Death
10062225 | A disorder characterized by a sensation of marked discomfort in the urinary tract. | Urinary tract pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10062233 | A disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues. | Uterine infection |  | - | Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10062244 | A disorder characterized by involvement of the paranasal sinuses. | Sinus disorder |  | Asymptomatic mucosal crusting; blood-tinged secretions | Symptomatic stenosis or edema/narrowing interfering with airflow; limiting instrumental ADL | Stenosis with significant nasal obstruction; limiting self care ADL | Necrosis of soft tissue or bone; urgent operative intervention indicated | Death
10062255 | A disorder characterized by an infectious process involving soft tissues. | Soft tissue infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10062263 | A disorder characterized by a narrowing of the lumen of the small intestine. | Small intestinal stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Symptomatic and severely altered GI function; tube feeding, [NAME] or hospitalization indicated; non-emergent operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10062283 | A disorder characterized by vertical or horizontal ridges on the nails. | Nail ridging |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | - | - | - | -
10062315 | A disorder characterized by hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin. | Lipohypertrophy |  | Asymptomatic and covering <10% BSA | Covering 10 - 30% BSA and associated tenderness; limiting instrumental ADL | Covering >30% BSA and associated tenderness and narcotics or NSAIDs indicated; lipohypertrophy; limiting self care ADL | - | -
10062466 | A disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site. | Localized edema |  | Localized to dependent areas, no disability or functional impairment | Moderate localized edema and intervention indicated; limiting instrumental ADL | Severe localized edema and intervention indicated; limiting self care ADL | - | -
10062501 | A disorder characterized by discomfort in the chest unrelated to a heart disorder. | Non-cardiac chest pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10062548 | A finding of bleeding from the trachea. | Tracheal hemorrhage |  | Minimal bleeding identified on clinical or diagnostic exam; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10062570 | A disorder characterized by an abnormal communication between the urinary bladder and the intestine. | Enterovesical fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; noninvasive intervention indicated | Severe, medically significant; medical intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10062572 | A disorder characterized by a reduction in the strength of muscles in multiple anatomic sites. | Generalized muscle weakness |  | Symptomatic; weakness perceived by patient but not evident on physical exam | Symptomatic; weakness evident on physical exam; weakness limiting instrumental ADL | Weakness limiting self care ADL; disabling | - | -
10062632 | A disorder characterized by an infectious process involving the gallbladder. | Gallbladder infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10062646 | A finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen. | Pancreatic enzymes decreased |  | <LLN and asymptomatic | Increase in stool frequency, bulk, or odor; steatorrhea | Sequelae of absorption deficiency | - | -
10062667 | A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx. | Laryngopharyngeal dysesthesia |  | Mild symptoms; no anxiety; intervention not indicated | Moderate symptoms; mild anxiety, but no dyspnea; short duration of observation and or anxiolytic indicated; limiting instrumental ADL | Severe symptoms; dyspnea and swallowing difficulty; limiting self care ADL | Life-threatening consequences | Death
10062872 | A disorder characterized by distortion of sensory perception, resulting in an abnormal and unpleasant sensation. | Dysesthesia |  | Mild sensory alteration | Moderate sensory alteration; limiting instrumental ADL | Severe sensory alteration; limiting self care ADL | - | -
10063057 | A disorder characterized by inflammation of the bladder which is not caused by an infection of the urinary tract. | Cystitis noninfective |  | Microscopic hematuria; minimal increase in frequency, urgency, dysuria, or nocturia; new onset of incontinence | Moderate hematuria; moderate increase in frequency, urgency, dysuria, nocturia or incontinence; urinary catheter placement or bladder irrigation indicated; limiting instrumental ADL | Gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated | Life-threatening consequences; urgent radiologic or operative intervention indicated | Death
10063190 | A disorder characterized by inflammation of the mucous membrane of the rectum. | Rectal mucositis |  | Asymptomatic or mild symptoms; intervention not indicated | Symptomatic; medical intervention indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent operative intervention indicated | Death
10063524 | A disorder characterized by a narrowing of the bronchial tube. | Bronchial stricture |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic (e.g., rhonchi or wheezing) but without respiratory distress; medical intervention indicated (e.g., steroids, bronchodilators) | Shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement) | Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated | Death
10063575 | A disorder characterized by a rupture in the bladder wall. | Bladder perforation |  | - | Extraperitoneal perforation, indwelling catheter indicated | Intraperitoneal perforation; elective radiologic, endoscopic or operative intervention indicated | Life-threatening consequences; organ failure; urgent operative intervention indicated | Death
10063636 | A disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include  an increase in the muscle tone in the lower extremities, hyperreflexia, positive [NAME] and a decrease in fine motor coordination. | Pyramidal tract syndrome |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10063761 | A disorder characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. It is an acute or subacute reversible condition. | Reversible posterior leukoencephalopathy syndrome |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; abnormal imaging studies; limiting instrumental ADL | Severe symptoms; very abnormal imaging studies; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10064026 | A disorder characterized by a reduction in the strength of the muscles of the pelvic floor. | Pelvic floor muscle weakness |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic, not interfering with bladder, bowel, or vaginal function; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10064505 | A disorder characterized by an infectious process involving a stoma (surgically created opening on the surface of the body). | Stoma site infection |  | Localized, local intervention indicated | Oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10064658 | A disorder characterized by a necrotic process occurring in the bone of the mandible. | Osteonecrosis of jaw |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated (e.g., topical agents); limiting instrumental ADL | Severe symptoms; limiting self care ADL; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10064687 | A disorder characterized by an infectious process involving the use of a medical device. | Device related infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10064774 | A disorder characterized by leakage of a pharmacologic or a biologic substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation and marked discomfort at the infusion site. | Infusion site extravasation |  |  | Erythema with associated symptoms (e.g., edema, pain, induration, phlebitis) | Ulceration or necrosis; severe tissue damage; operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10064848 | A disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure. | Chronic kidney disease |  | eGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) <LLN - 60 ml/min/1.73 m2 or proteinuria 2+ present; urine protein/creatinine >0.5 | eGFR or CrCl 59 - 30 ml/min/1.73 m2 | eGFR or CrCl 29 - 15 ml/min/1.73 m2 | eGFR or CrCl <15 ml/min/1.73 m2; dialysis or renal transplant indicated | Death
10065368 | A disorder characterized by an abnormal communication between any part of the urinary system and another organ or anatomic site. | Urinary fistula |  | - | Noninvasive intervention indicated; urinary or suprapubic catheter placement indicated | Limiting self care ADL; elective radiologic, endoscopic or operative intervention indicated; permanent urinary diversion indicated | Life-threatening consequences; urgent radiologic or operative intervention indicated | Death
10065417 | A disorder characterized by regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand. | Brachial plexopathy |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10065703 | A disorder characterized by a narrowing of the lumen of the pancreatic duct. | Pancreatic duct stenosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065704 | A disorder characterized by a necrotic process occurring in the peritoneum. | Peritoneal necrosis |  | - | - | Tube feeding or [NAME]  indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065705 | A finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures). | Pharyngeal anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065706 | A disorder characterized by a necrotic process occurring in the pharynx. | Pharyngeal necrosis |  | - | - | Inability to aliment adequately by GI tract; tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065707 | A disorder characterized by blockage of the normal flow of the intestinal contents in the rectum. | Rectal obstruction |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Hospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10065709 | A disorder characterized by a necrotic process occurring in the rectal wall. | Rectal necrosis |  | - | - | Tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065710 | A disorder characterized by inflammation of the mucous membrane of the small intestine. | Small intestinal mucositis |  | Asymptomatic or mild symptoms; intervention not indicated | Symptomatic; medical intervention indicated; limiting instrumental ADL | Severe pain; interfering with oral intake; tube feeding, [NAME] or hospitalization indicated; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10065712 | A finding of a necrotic process occurring in the gastrointestinal tract stoma. | Gastrointestinal stoma necrosis |  | - | Superficial necrosis; intervention not indicated | Severe symptoms; hospitalization or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065713 | A disorder characterized by an abnormal communication between the stomach and another organ or anatomic site. | Gastric fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; bowel rest; tube feeding, [NAME] or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065719 | A disorder characterized by an abnormal communication between the jejunum and another organ or anatomic site. | Jejunal fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; [NAME] or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065720 | A disorder characterized by an abnormal communication between the oral cavity and another organ or anatomic site. | Oral cavity fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; [NAME] or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065721 | A disorder characterized by inflammation of the mucous membrane of the anus. | Anal mucositis |  | Asymptomatic or mild symptoms; intervention not indicated | Symptomatic; medical intervention indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10065722 | A disorder characterized by a necrotic process occurring in the anal region. | Anal necrosis |  | - | - | TPN or hospitalization indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065727 | A disorder characterized by a necrotic process occurring in the esophageal wall. | Esophageal necrosis |  | - | - | Inability to aliment adequately by GI tract; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065728 | A disorder characterized by an abnormal communication between the ileum and another organ or anatomic site. | Ileal fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; [NAME] or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065730 | A disorder characterized by blockage of the normal flow of the intestinal contents in the ileum. | Ileal obstruction |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Hospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10065732 | A disorder characterized by blockage of the normal flow of the intestinal contents in the jejunum. | Jejunal obstruction |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Hospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death
10065735 | A disorder characterized by an inflammation involving the larynx. | Laryngeal inflammation |  | Mild sore throat; [NAME] voice | Moderate sore throat; analgesics indicated | Severe throat pain; endoscopic intervention indicated | - | -
10065738 | A disorder characterized by of a discrepancy between the lengths of the lower or upper extremities. | Unequal limb length |  | Mild length discrepancy <2 cm | Moderate length discrepancy 2 - 5 cm; shoe lift indicated; limiting instrumental ADL | Severe length discrepancy >5 cm; limiting self care ADL; disabling; operative intervention indicated | - | -
10065744 | A disorder characterized by an infectious process involving an artery. | Arteritis infective |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065745 | A finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface. | Prolapse of intestinal stoma |  | Asymptomatic; reducible | Recurrent after manual reduction; local irritation or stool leakage; difficulty to fit appliance; limiting instrumental ADL | Severe symptoms; elective operative intervention indicated; limiting self care ADL | Life-threatening consequences; urgent operative intervention indicated | Death
10065746 | A disorder characterized by bleeding from the bronchial wall and/or lung parenchyma. | [NAME] hemorrhage |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | Transfusion, radiologic, endoscopic, or operative intervention indicated (e.g., hemostasis of bleeding site) | Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated | Death
10065747 | A disorder characterized by bleeding from the cecum. | Cecal hemorrhage |  | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065748 | A finding of bleeding from the urostomy site. | Urostomy site bleeding |  | Minimal bleeding identified on clinical exam; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065749 | A finding of blood leakage from the tracheostomy site. | Tracheostomy site bleeding |  | Minimal bleeding identified on clinical exam; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065752 | A disorder characterized by an infectious process involving the duodenum. | Duodenal infection |  | - | Moderate symptoms; medical intervention indicated (e.g., oral antibiotics) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065755 | A disorder characterized by an infectious process involving the lips. | Lip infection |  | Localized, local intervention indicated | Oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | - | -
10065759 | A disorder characterized by bleeding from the larynx. | Laryngeal hemorrhage |  | Mild cough or trace hemoptysis; laryngoscopic findings | Moderate symptoms; medical intervention indicated | Transfusion, radiologic, endoscopic, or operative intervention indicated (e.g., hemostasis of bleeding site) | Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) | Death
10065761 | A disorder characterized by an infectious process involving the cecum. | Cecal infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065762 | A disorder characterized by bleeding from the spermatic cord. | Spermatic cord hemorrhage |  | Minimal bleeding identified on imaging study; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065763 | A disorder characterized by bleeding from the ovary. | Ovarian hemorrhage |  | Minimal bleeding identified on imaging study or laproscopy; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic  intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065764 | A disorder characterized by an infectious process involving a mucosal surface. | Mucosal infection |  | Localized, local intervention indicated | Oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065765 | A disorder characterized by an infectious process involving a cranial nerve. | Cranial nerve infection |  | - | - | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065766 | A disorder characterized by an infectious process involving the peripheral nerves. | Peripheral nerve infection |  | - | Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065771 | A disorder characterized by an infectious process involving the small intestine. | Small intestine infection |  | - | Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065772 | A disorder characterized by an infectious process involving the vulva. | Vulval infection |  | Localized, local intervention indicated | Oral intervention indicated (e.g., antibiotic, antifungal, antiviral) | IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065773 | A disorder characterized by the loss of lymph fluid into the surrounding tissue or body cavity. | Lymph leakage |  | - | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065775 | A disorder characterized by a necrotic process occurring in the soft tissues of the abdominal wall. | Abdominal soft tissue necrosis |  | - | Local wound care; medical intervention indicated (e.g., dressings or topical medications) | Operative debridement or other invasive intervention indicated (e.g. tissue reconstruction, flap or grafting) | Life-threatening consequences; urgent intervention indicated | Death
10065776 | A disorder characterized by a reduction in the strength of the lower limb muscles. | Muscle weakness lower limb |  | Symptomatic; perceived by patient but not evident on physical exam | Symptomatic; evident on physical exam; limiting instrumental ADL | Limiting self care ADL; disabling | - | -
10065777 | A disorder characterized by a necrotic process occurring in the soft tissues of the lower extremity. | Soft tissue necrosis lower limb |  | - | Local wound care; medical intervention indicated (e.g., dressings or topical medications) | Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) | Life-threatening consequences; urgent intervention indicated | Death
10065778 | A disorder characterized by a necrotic process occurring in the soft tissues of the upper extremity. | Soft tissue necrosis upper limb |  | - | Local wound care; medical intervention indicated (e.g., dressings or topical medications) | Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) | Life-threatening consequences; urgent intervention indicated | Death
10065779 | A disorder characterized by a necrotic process occurring in the soft tissues of the head. | Head soft tissue necrosis |  |  | Local wound care; medical intervention indicated (e.g., dressings or topical medications) | Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) | Life-threatening consequences; urgent intervention indicated | Death
10065780 | A disorder characterized by a reduction in the strength of the muscles on the left side of the body. | Muscle weakness left-sided |  | Symptomatic; perceived by patient but not evident on physical exam | Symptomatic; evident on physical exam; limiting instrumental ADL | Limiting self care ADL; disabling | - | -
10065781 | A disorder characterized by a necrotic process occurring in the soft tissues of the neck. | Neck soft tissue necrosis |  | - | Local wound care; medical intervention indicated (e.g., dressings or topical medications) | Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) | Life-threatening consequences; urgent intervention indicated | Death
10065783 | A disorder characterized by of a malformation of the musculoskeletal system. | Musculoskeletal deformity |  | Cosmetically and functionally insignificant hypoplasia | Deformity, hypoplasia, or asymmetry able to be remediated by prosthesis (e.g., shoe insert) or covered by clothing | Significant deformity, hypoplasia, or asymmetry, unable to be remediated by prosthesis or covered by clothing; disabling | - | -
10065784 | A disorder characterized by a necrotic process occurring in the brain and/or spinal cord. | Central nervous system necrosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; corticosteroids indicated | Severe symptoms; medical intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065785 | A disorder characterized by a sensation of marked discomfort in the external ear region. | External ear pain |  | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | -
10065786 | A disorder characterized by an abnormal communication between the larynx and another organ or anatomic site. | Laryngeal fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) | Life-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies) | Death
10065787 | A disorder characterized by an abnormal communication between the trachea and another organ or anatomic site. | Tracheal fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) | Life-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies) | Death
10065788 | A finding of leakage due to breakdown of a fallopian tube anastomosis (surgical connection of two separate anatomic structures). | Fallopian tube anastomotic leak |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065789 | A disorder characterized by blockage of the normal flow of the contents in the fallopian tube. | Fallopian tube obstruction |  | Diagnostic observations only; intervention not indicated | Mild symptoms; elective intervention indicated | Severe symptoms; elective operative intervention indicated | - | -
10065790 | A finding of rupture of the fallopian tube wall. | Fallopian tube perforation |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated (e.g., organ resection) | Death
10065791 | A disorder characterized by a narrowing of the fallopian tube lumen. | Fallopian tube stenosis |  | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated (e.g., organ resection) | Death
10065793 | A disorder characterized by a necrotic process occurring in the soft tissues of the pelvis. | Pelvic soft tissue necrosis |  | - | Local wound care; medical intervention indicated (e.g., dressings or topical medications) | Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) | Life-threatening consequences; urgent intervention indicated | Death
10065794 | A disorder characterized by a reduction in the strength of the muscles on the right side of the body. | Muscle weakness right-sided |  | Symptomatic; perceived by patient but not evident on physical exam | Symptomatic; evident on physical exam; limiting instrumental ADL | Limiting self care ADL; disabling | - | -
10065795 | A disorder characterized by a reduction in the strength of the trunk muscles. | Muscle weakness trunk |  | Symptomatic; perceived by patient but not evident on physical exam | Symptomatic; evident on physical exam; limiting instrumental ADL | Limiting self care ADL; disabling | - | -
10065796 | A disorder characterized by a decrease in flexibility of a cervical spine joint. | Joint range of motion decreased cervical spine |  | Mild restriction of rotation or flexion between 60 - 70 degrees | Rotation <60 degrees to right or left; <60 degrees of flexion | Ankylosed/fused over multiple segments with no C-spine rotation | - | -
10065798 | A disorder characterized by fibrotic degeneration of the superficial soft tissues. | Superficial soft tissue fibrosis |  | Mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) | Moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL | Severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL | Generalized; associated with signs or symptoms of impaired breathing or feeding | Death
10065799 | A disorder characterized by fibrotic degeneration of the deep connective tissues. | Fibrosis deep connective tissue |  | Mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) | Moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL | Severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g. mouth, anus); limiting self care ADL | Generalized; associated with signs or symptoms of impaired breathing or feeding | Death
10065800 | A disorder characterized by a decrease in flexibility of a lumbar spine joint. | Joint range of motion decreased lumbar spine |  | Stiffness; difficulty bending to the floor to pick up a very light object but able to do athletic activity | Pain with range of motion (ROM) in lumbar spine; requires a reaching aid to pick up a very light object from the floor | <50% lumbar spine flexion; associated with symptoms of ankylosis or fused over multiple segments with no L-spine flexion (e.g., unable to reach to floor to pick up a very light object) | - | -
10065802 | A finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures). | Bladder anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065803 | A finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures). | Kidney anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065805 | A disorder characterized by blockage of the normal flow of the contents of the spermatic cord. | Spermatic cord obstruction |  | Diagnostic observations only; intervention not indicated | Mild symptoms; elective intervention indicated | Severe symptoms; elective operative intervention indicated | - | -
10065811 | A disorder characterized by an abnormal communication between the uterus and another organ or anatomic site. | Uterine fistula |  | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065813 | A disorder characterized by an abnormal communication between the vagina and another organ or anatomic site. | Vaginal fistula |  | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065814 | A finding of leakage due to breakdown of a ureteral anastomosis (surgical connection of two separate anatomic structures). | Ureteric anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065815 | A finding of leakage due to breakdown of a urethral anastomosis (surgical connection of two separate anatomic structures). | Urethral anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065817 | A disorder characterized by blockage of vaginal canal. | Vaginal obstruction |  | Diagnostic observations only; intervention not indicated | Mild symptoms; elective intervention indicated | Severe symptoms; elective operative intervention indicated | - | -
10065818 | A disorder characterized by a rupture in the vaginal wall. | Vaginal perforation |  | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065822 | A finding of displacement of the urostomy. | Prolapse of urostomy |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Local care or maintenance; minor revision indicated | Dysfunctional stoma; elective operative intervention or major stomal revision indicated | Life-threatening consequences; urgent intervention indicated | Death
10065823 | A disorder characterized by a malformation of the nipple. | Nipple deformity |  | Asymptomatic; asymmetry with slight retraction and/or thickening of the nipple areolar complex | Symptomatic; asymmetry of nipple areolar complex with moderate retraction and/or thickening of the nipple areolar complex | - | - | -
10065825 | A finding of damage to the gastrointestinal system during a surgical procedure. | Intraoperative gastrointestinal injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065826 | A finding of damage to an artery during a surgical procedure. | Intraoperative arterial injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065827 | A finding of damage to the hepatic parenchyma and/or biliary tract during a surgical procedure. | Intraoperative hepatobiliary injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065828 | A finding of damage to the urinary system during a surgical procedure. | Intraoperative urinary injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065829 | A finding of damage to the musculoskeletal system during a surgical procedure. | Intraoperative musculoskeletal injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065830 | A finding of damage to the nervous system during a surgical procedure. | Intraoperative neurological injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065831 | A finding of damage to the breast parenchyma during a surgical procedure. | Intraoperative breast injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065832 | A finding of damage to the respiratory system during a surgical procedure. | Intraoperative respiratory injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065834 | A finding of damage to the endocrine gland during a surgical procedure. | Intraoperative endocrine injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065836 | A disorder characterized by involvement of the trochlear nerve (fourth cranial nerve). | IVth nerve disorder |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | -
10065837 | A disorder characterized by inflammation, swelling and redness to the outer ear and ear canal. | External ear inflammation |  | External otitis with erythema or dry desquamation | External otitis with moist desquamation, edema, enhanced cerumen or discharge; tympanic membrane perforation; tympanostomy | External otitis with mastoiditis; stenosis or osteomyelitis; necrosis of soft tissue or bone | Urgent operative intervention indicated | Death
10065838 | A disorder characterized by inflammation (physiologic response to irritation), swelling and redness to the middle ear. | Middle ear inflammation |  | Serous otitis | Serous otitis, medical intervention indicated | Mastoiditis; necrosis of canal soft tissue or bone | Life-threatening consequences; urgent intervention indicated | Death
10065840 | A finding of damage to the reproductive organs during a surgical procedure. | Intraoperative reproductive tract injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065841 | A finding of damage to the eye during a surgical procedure. | Intraoperative ocular injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065842 | A finding of damage to the head and neck during a surgical procedure. | Intraoperative head and neck injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065843 | A finding of damage to the heart during a surgical procedure. | Intraoperative cardiac injury |  | - | - | Primary repair of injured organ/structure indicated | Life-threatening consequences; urgent intervention indicated | Death
10065844 | A finding of damage to the ear during a surgical procedure. | Intraoperative ear injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection of injured organ/structure indicated; disabling (e.g., impaired hearing; impaired balance) | Life-threatening consequences; urgent intervention indicated | Death
10065845 | A finding of damage to the kidney during a surgical procedure. | Intraoperative renal injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065846 | A finding of damage to the skin during a surgical procedure. | Intraoperative skin injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065847 | A finding of damage to the spleen during a surgical procedure. | Intraoperative splenic injury |  | - | Primary repair of injured organ/structure indicated | Resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065848 | A finding of damage to a vein during a surgical procedure. | Intraoperative venous injury |  | Primary repair of injured organ/structure indicated | Partial resection of injured organ/structure indicated | Complete resection or reconstruction of injured organ/structure indicated; disabling | Life-threatening consequences; urgent intervention indicated | Death
10065849 | A finding of damage to the jugular vein. | Injury to [NAME] |  | - | - | Symptomatic limiting self care ADL; disabling; repair or revision indicated | Life-threatening consequences; urgent intervention indicated | Death
10065851 | A disorder characterized by an abnormal communication between the esophagus and another organ or anatomic site. | Esophageal fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding, [NAME] or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10065873 | A disorder characterized by an abnormal communication between the lung and another organ or anatomic site. | [NAME] fistula |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL | Limiting self care ADL; endoscopic stenting or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065879 | A finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical connection of two separate anatomic structures). | Gastrointestinal anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065880 | A disorder characterized by an inflammation involving the mucous membrane of the larynx. | Laryngeal mucositis |  | Endoscopic findings only; mild discomfort with normal intake | Moderate discomfort; altered oral intake | Severe pain; severely altered eating/swallowing; medical intervention indicated | Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) | Death
10065881 | A disorder characterized by an inflammation involving the mucous membrane of the pharynx. | Pharyngeal mucositis |  | Endoscopic findings only; minimal symptoms with normal oral intake; mild pain but analgesics not indicated | Moderate pain and analgesics indicated; altered oral intake; limiting instrumental ADL | Severe pain; unable to adequately aliment or hydrate orally; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10065882 | A finding of leakage of contents from a urostomy. | Urostomy leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065883 | A finding of blockage of the urostomy. | Urostomy obstruction |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; dilation or endoscopic repair or stent placement indicated | Altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); elective operative intervention indicated | Life-threatening consequences; organ failure; urgent operative intervention indicated | Death
10065885 | A finding of narrowing of the opening of a urostomy. | Urostomy stenosis |  | - | Symptomatic but no hydronephrosis, no sepsis or no renal dysfunction; dilation or endoscopic repair or stent placement indicated | Symptomatic (e.g., hydronephrosis, or renal dysfunction); elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065886 | A finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures). | Uterine anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065887 | A finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures). | Vaginal anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065888 | A finding of leakage due to breakdown of a vas deferens anastomosis (surgical connection of two separate anatomic structures). | Vas deferens anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065891 | A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine. | Large intestinal anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065892 | A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the small bowel. | Small intestinal anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065893 | A finding of leakage due to breakdown of a gastric anastomosis (surgical connection of two separate anatomic structures). | Gastric anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065894 | A finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures). | Rectal anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065895 | A disorder characterized by a reduction in the strength of the upper limb muscles. | Muscle weakness upper limb |  | Symptomatic; perceived by patient but not evident on physical exam | Symptomatic; evident on physical exam; limiting instrumental ADL | Limiting self care ADL; disabling | - | -
10065897 | A finding of leakage due to breakdown of a spermatic cord anastomosis (surgical connection of two separate anatomic structures). | Spermatic cord anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065898 | A finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body). | Stenosis of gastrointestinal stoma |  | - | Symptomatic; IV fluids indicated <24 hrs; manual dilation at bedside | Severely altered GI function; tube feeding, [NAME] or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065900 | A disorder characterized by an inflammation involving the mucous membrane of the trachea. | Tracheal mucositis |  | Endoscopic findings only; minimal hemoptysis, pain, or respiratory symptoms | Moderate symptoms; medical intervention indicated; limiting instrumental ADL | Severe pain; hemorrhage or respiratory symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death
10065906 | A finding based on lung function test results that indicate  a decrease in the lung capacity to absorb carbon monoxide. | Carbon monoxide diffusing capacity decreased |  | 3 - 5 units below LLN; for follow-up, a decrease of 3 - 5 units (ml/sec/[NAME]) below the baseline value | 6 - 8 units below LLN; for follow-up, an asymptomatic decrease of >5 - 8 units (ml/sec/[NAME]) below the baseline value | Asymptomatic decrease  of >8 units drop;  >5 units drop along with the presence of pulmonary symptoms (e.g. , >Grade 2  hypoxia or >Grade 2 or higher dyspnea) | - | -
10065928 | A disorder characterized by blockage of the uterine outlet. | Uterine obstruction |  | Diagnostic observations only; intervention not indicated | Mild symptoms; elective intervention indicated | Severe symptoms; elective operative intervention indicated | - | -
10065961 | A finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures). | Esophageal anastomotic leak |  | Asymptomatic diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death
10065973 | A disorder characterized by accumulation of iron in the tissues. | Iron overload |  | - | Moderate symptoms; intervention not indicated | Severe symptoms; intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10066480 | A disorder characterized by necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure. | Avascular necrosis |  | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; limiting instrumental ADL | Severe symptoms; limiting self care ADL; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death
10066874 | A disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is chronic in nature and usually caused by incompetence of the lower esophageal sphincter, and may result in injury to the esophageal mucosal. Symptoms include heartburn and acid indigestion. | Gastroesophageal reflux disease |  | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | Severe symptoms; surgical intervention indicated | - | -
10069138 | A disorder characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back Unlike acne, this rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions. | Papulopustular rash |  | [NAME] covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness | [NAME] covering 10-30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL | [NAME] covering >30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; limiting self-care ADL; associated with local superinfection with oral antibiotics indicated | [NAME] covering  any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences | Death
10069339 | A disorder characterized by the acute loss of renal function and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction). | Acute kidney injury |  | Creatinine level increase of >0.3 mg/dL; creatinine 1.5 - 2.0 x above baseline | [NAME] x above baseline | Creatinine >3 x baseline or >4.0 mg/dL; hospitalization indicated | Life-threatening consequences; dialysis indicated | Death
10069501 | A disorder characterized by failure of the left ventricle to produce adequate output despite an increase in distending pressure and in end-diastolic volume. Clinical manifestations may include dyspnea, orthopnea, and other signs and symptoms of pulmonary congestion and edema. | Left ventricular systolic dysfunction |  | - | - | Symptomatic due to drop in ejection fraction responsive to intervention | Refractory or poorly controlled heart failure due to drop in ejection fraction; intervention such as ventricular assist device, intravenous vasopressor support, or heart transplant indicated | Death