Spreadsheet: 488dd515-126a-4ca2-9949-7cd33688fc37
Sheet: Sheet1

Supplementary File S1 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10
[NAME] et [NAME],
A Genome-wide Screen for Genetic Variants that Modify the Recruitment of REST to its Target Genes
 |  |  |  |  |  | Notes
 |  |  |  |  |  | Genes whose expression level directly responds to REST knockdown are indicated in the column “Known REST Target?”. The cell types where this has been observed are shown (HEK293, T47D, MCF10a from Wagoner et al, VASCULAR SMOOTH MUSCLE from Cheong et al).
pRE1 ID | Location (hg18) | FB Change (Minor - Major) | P-Value (t Test) | SNP ID | Frequency | Refseq ID | [NAME] | Location of pRE1 relative to gene TSS (- indicates upstream) | Known REST Target? | Disease Association
pRE1-1 | [NAME] | 0.143680244988131 | 0.002232632681385712 | rs591282 | CEU* | NM_024420 | PLA2G4A | 1184632 | - | Schizophrenia
pRE1-2 | chr10:16694444 | 0.1771151317609536 | 6.57281955286226e-05 | rs57270723 | ND | NM_001010908 | C1QL1 | -90434 | -
pRE1-3 | chr8:21916675 | 0.0475776617984105 | 0.06356319988413917 | rs34033679 | ND | NM_182795 | NPM2 | -20916 | -
pRE1-4 | chr22:14705804 | 0.1331204598041112 | 0.0002514113563167238 | rs2051229 | ND | NM_001136213 | POTEH | -37867 | -
pRE1-5-1 | chr14:90031546 | 0.220049648580453 | 0.0002048688236290431 | rs12893721 | ND | NM_006888 | [NAME] | 98420 | - | Osteoarthritis
pRE1-5-2 | chr14:90031546 | 0.2633813214831522 | 0.01023420847315179 | rs12893572 | ND | NM_006888 | [NAME] | 98420 | - | Osteoarthritis
pRE1-6 | chr10:83728154 | -0.156369792277421 | 1.097261920232677e-06 | rs11192022 | ND | NM_001010848 | NRG3 | 103077 | - | Schizophrenia
pRE1-7 | chr19:15052029 | -0.01462941030899911 | 0.06776525301084611 | rs58011966 | ND | NM_001004713 | OR1I1 | -6848 | -
pRE1-8 | chr1:207390270 | -0.006362021006039109 | 0.3653617391940803 | rs36021787 | ND | [NAME] | [NAME] | -433415 | -
pRE1-9 | chr18:39881775 | -0.2985884684862258 | 0.03126560708792253 | rs8092075 | CEU* | NM_015559 | SETBP1 | -633086 | - | Acute myeloid leukemia
pRE1-10 | [NAME] | 0.02544987923565156 | 1.305995126065603e-05 | [NAME] | CEU* | NM_000549 | TSHB | 27336 | - | Hypothyroidism
pRE1-11 | chr16:7829717 | 0.01466373701333462 | 0.1946494179782578 | rs61607025 | CEU* | NM_145893 | A2BP1 | 506965 | - | Primary billiary cirrhosis
pRE1-12 | chr3:43338484 | -0.03476029252250679 | 0.1266094722671982 | rs56225070 | ND | NM_017719 | SNRK | 35384 | -
pRE1-13 | chr11:88077514 | -0.08177763361329099 | 0.0004209062844243035 | rs4489745 | CHB,[NAME] | NM_000842 | GRM5 | 343324 | - | Schizophrenia
pRE1-14 | chr7:5225705 | -0.08282678358804696 | 0.001983771806806181 | rs28479319 | CEU* | NM_001033520 | WIPI2 | 5210 | -
pRE1-15 | chr6:117024868 | 0.1027483499631014 | 0.002390980858351657 | [NAME] | - | NM_001010892 | RSPH4A | -19475 | - | [NAME]
pRE1-16 | chr1:18261461 | -0.06870364441549279 | 0.03280157984514818 | rs12037125 | - | NM_032880 | IGSF21 | -45366 | HEK293
pRE1-17 | chr16:16698870 | 0.1016665900340499 | 0.001522808057256984 | rs62041546 | ND | NM_001004067 | NOMO3 | 464917 | -
pRE1-18 | chr14:77935587 | 0.07884094427145161 | 0.001888532984610296 | rs11159355 | CEU* | NM_004796 | NRXN3 | -251734 | - | Waist circumference, addiction
pRE1-19 | chr22:28204664 | 0.1879030152710234 | 0.0019392369121306 | rs59221441 | ND | NM_021076 | NEFH | -1555 | HEK293 | Amyotrophic lateral sclerosis
pRE1-20 | chr19:11320989 | 0.258537384891587 | 2.396523987964371e-06 | rs12984429 | ND | NM_198536 | TMEM205 | -3267 | -
pRE1-21 | chr7:1719768 | 0.1061921561058246 | 0.01825394145239483 | rs11767622 | ND | NM_032302 | PSMG3 | -143613 | -
pRE1-22 | chr22:25675371 | -0.1249385394152451 | 0.01204609405376812 | rs5761858 | CEU | NR_003491 | MIAT | 272933 | - | Myocardial infarction
pRE1-23 | chr17:23114277 | 0.2537338348228591 | 5.89470043551902e-05 | rs28944187 | ND | NM_000625 | NOS2 | 37405 | HEK293 | Hypertension, malaria infection
pRE1-24 | chr8:143374761 | -0.2534361180372053 | 7.638607426050405e-05 | rs28396985 | CEU* | NM_145003 | TSNARE1 | 107683 | -
pRE1-25 | chr5:162925224 | 0.1252467872490131 | 0.002924320317494262 | rs17061938 | YRI | NM_013283 | MAT2B | 60061 | -
pRE1-26 | chr20:59960608 | 0.02564156165620374 | 0.128528039122793 | [NAME] | ND | NM_003185 | TAF4 | 113653 | - | Huntington's disease
pRE1-27 | chr19:60383380 | 0.1108771291401939 | 0.00481992936660363 | [NAME] | CEU* | NM_003180 | SYT5 | 152 | T47D
pRE1-28 | chr3:67247090 | -0.005346242381643607 | 0.4126116185141167 | rs57994085 | ND | NM_032505 | KBTBD8 | 114997 | - | Height
pRE1-29 | chr20:30660276 | 0.05844114840394793 | 0.03060587605975118 | rs41293136 | ND | NM_182584 | CR20ORF203 | 22813 | -
pRE1-30 | chr11:983956 | 0.0298701559100053 | 0.1044507976876239 | rs35001393 | ND | NM_005961 | MUC6 | 42750 | -
pRE1-31-1 | chr5:1476347 | 0.2551142185994681 | 1.270771952711539e-05 | rs423091 | ND | NM_001044 | SLC6A3 | 20012 | - | Attention deficit hyperactivity disorder, major affective disorder, tobacco addiction
pRE1-31-2 | chr5:1476347 | 0.07626146717494497 | 0.001282389687637654 | rs28380002 | ND | NM_001044 | SLC6A3 | 20012 | - | Attention deficit hyperactivity disorder, major affective disorder, tobacco addiction
pRE1-32 | chr1:241249144 | 0.2485424362901094 | 4.209244901950072e-06 | rs61823647 | ND | NM_001042405 | CEP170 | 236102 | -
pRE1-33 | chr15:81129125 | 0.347908443212842 | 1.717833815601736e-07 | rs2303988 | ND | NM_030594 | CPEB1 | -15342 | HEK293 | Chronic lymphocytic leukemia
pRE1-34 | chr3:13901643 | 0.3031117521020135 | 7.856368313011289e-06 | rs12629044 | CEU* | NM_004625 | WNT7A | -5024 | - | Limb deformity
pRE1-35 | chr16:47121638 | 0.2357943210000025 | 6.636229863581151e-06 | rs6500392 | CEU* | NM_153029 | N4BP1 | 79983 | -
pRE1-36 | chr20:58929675 | -0.5299065422069846 | 8.59126483051368e-07 | rs6093022 | CEU* | NM_001794 | CDH4 | -331290 | HEK293 | Colorectal cancer, gastric cancer
pRE1-37 | chr1:11828357 | 0.4682056605208955 | 1.282048567144241e-06 | rs12565 | ND | NM_006172 | NPPA | 2070 | VASCULAR SMOOTH MUSCLE | Familial atrial fibrillation
pRE1-38-1 | chr2:91125788 | 0.06272476532940563 | 0.008831716469328703 | [NAME] | ND | NM_144563 | RPIA | 2353497 | - | Ribose 5-phosphate isomerase deficiency
pRE1-38-2 | chr2:91125788 | 0.2555636380828377 | 0.002743938840289986 | [NAME] | ND | NM_144563 | RPIA | 2353497 | - | Ribose 5-phosphate isomerase deficiency
pRE1-38-3 | chr2:91125788 | 0.1367468531497252 | 9.636150045113073e-05 | rs2891918 | ND | NM_144563 | RPIA | 2353497 | - | Ribose 5-phosphate isomerase deficiency
pRE1-39 | chr1:38314496 | 0.03289254366842059 | 0.07882584650304751 | rs12129855 | - | NM_002699 | POU3F1 | -29443 | - | Schizophrenia
pRE1-40 | chr3:86414208 | -0.06312975254528075 | 0.008988626294002516 | [NAME] | ND | NM_153184 | CADM2 | 555886 | -
pRE1-41 | chr22:33578108 | 0.182338959122646 | 6.882198844260939e-05 | rs9610164 | ND | NM_001008494 | ISX | -214022 | - | Vitamin A metabolism
pRE1-42 | chr20:43577393 | 0.2028222294684959 | 0.002364905915136476 | rs6130854 | ND | NM_080827 | WFDC6 | 24155 | MCF10a
pRE1-43 | chr19:38576373 | 0.2389704908855418 | 0.0002662015415457781 | [NAME] | ND | NM_001806 | CEBPG | 19924 | - | Acute myeloid leukemia
pRE1-44 | chr19:41256390 | 0.1467844918576899 | 0.0005593499899652607 | rs56218447 | ND | NM_001083961 | WDR62 | 18730 | -
pRE1-45 | chr5:169971519 | 0.04192890787098968 | 0.001861805113072372 | rs35408805 | ND | NM_014592 | KCNIP1 | 107364 | - | Schizophrenia
pRE1-46 | chr1:6985569 | 0.05026024524265305 | 0.02231505106437854 | rs11120813 | CHB,CEU,[NAME],YRI | NM_015215 | CAMTA1 | 217598 | - | Neuroblastoma
pRE1-47 | [NAME] | 0.04950040339147688 | 0.008452864930301195 | rs35657407 | ND | NM_018014 | BCL11A | 267250 | - | Foetal haemoglobin
pRE1-48 | chr11:126052725 | 0.06467168912765553 | 0.008289827510728464 | rs12291640 | - | NM_032531 | [NAME] | -114703 | - | Mental retardation
pRE1-49 | chr20:40686144 | 0.185163224049621 | 4.38139630625093e-05 | rs1040480 | CHB,CEU,[NAME],YRI | NM_133170 | PTPRT | 565643 | - | Various cancers
pRE1-50 | chr7:64922879 | 0.2156138095165625 | 9.086259031793049e-06 | rs62469938 | ND | [NAME] | VKORC1L1 | -52880 | -
pRE1-51 | chr11:49830461 | 0.1509477858016762 | 0.02072330820467392 | rs61904469 | CEU* | NM_001001955 | OR4C13 | -100090 | -
pRE1-52 | chr19:41062717 | 0.02673165218974619 | 0.07532241710878755 | rs61623584 | ND | NM_001024807 | APLP1 | 11476 | HEK293 | Tumour suppressor
pRE1-53 | chr10:125222245 | -0.08800333626594115 | 0.007200430049254847 | rs12244739 | CEU,YRI | NM_153442 | GPR26 | -193616 | - | Glioblastoma
pRE1-54 | chr13:29431404 | 0.09807513500236142 | 0.008803463732040273 | rs745252 | ND | NM_007106 | UBL3 | -108584 | -
pRE1-55 | [NAME] | 0.205784232156372 | 2.9757324234345e-05 | rs6062472 | ND | NM_015894 | STMN3 | 8012 | HEK293, T47D, MCF10a
pRE1-56 | chr4:3840072 | -0.1080670342746501 | 0.001355633510724544 | rs3979 | CEU* | NM_000683 | ADRA2C | 101978 | - | Congestive heart failure
pRE1-57 | chr8:137199432 | 0.2718293020718415 | 0.002798637640270353 | rs62526589 | CEU* | NM_006558 | KHDRBS3 | 660550 | - | Medulloblastoma, childhood absence epilepsy
pRE1-58 | chr8:143374733 | 0.1062832187844316 | 0.003623618657196457 | rs28396985 | ND | NM_145003 | TSNARE1 | 107711 | -
pRE1-59 | chr9:118157319 | -0.1597485728063079 | 0.0001560461161746463 | rs11356865 | ND | NM_002581 | PAPPA | 201427 | - | Cardiac disease, birthweight
pRE1-60 | chr19:4720717 | 0.2300701216252805 | 0.0002703830899674833 | rs28713481 | ND | NR_027148 | PGSF3 | 600 | -
pRE1-61 | chr22:32763132 | 0.2821424366083541 | 1.597008406003319e-05 | rs5994827 | ND | NM_133642 | LARGE | -116722 | - | Muscular dystrophy
pRE1-62 | chr3:10153511 | 0.215473112513111 | 1.042904830050741e-07 | rs6796538 | CEU* | NM_198156 | VHL | -4808 | - | Erythrocytosis, pheochromocytoma, renal cell carcinoma
pRE1-63 | chr1:157444668 | 0.1059226299296312 | 0.001390368132468449 | rs34154675 | ND | NM_002036 | DARC | 4947 | - | Malaria, white blood cell count
pRE1-64 | chr11:129340555 | 0.4978563882601153 | 1.207396563690036e-06 | rs12802622 | CEU,[NAME],YRI | NM_199439 | PRDM10 | -17828 | -
pRE1-65 | chr11:11345063 | 0.270903368658141 | 4.399376909973505e-06 | rs16909532 | - | NM_198516 | GALNTL4 | 255062 | -
pRE1-66 | chr15:41449889 | 0.1028487921565979 | 0.01280840625272914 | [NAME] | ND | NM_152455 | ZSCAN29 | -339 | -
pRE1-67 | chr16:88422513 | 0.3738051653444823 | 0.0001210749191726901 | rs2376876 | ND | NM_032451 | SPIRE2 | 105 | MCF10a
pRE1-68 | chr17:69101976 | -0.05335951699574881 | 0.0002791133523080701 | rs34261915 | ND | NM_001144952 | SDK2 | 49846 | - | Panic disorder
pRE1-69 | chr22:33141085 | -0.1241244665726622 | 0.002740819320785412 | rs9621935 | ND | NM_133642 | LARGE | -494675 | - | Muscular dystrophy
pRE1-70 | chr10:94137238 | 0.265451227045745 | 0.0001914849936864045 | [NAME] | - | NM_017824 | [NAME] | 96338 | -
pRE1-71 | chr14:102663364 | -0.0330044121764258 | 0.03437976063519711 | rs12884397 | ND | NM_006291 | TNFAIP2 | 947 | -
pRE1-72 | chr15:75894622 | 0.1935314740495198 | 1.299208131354704e-05 | rs55805135 | ND | NM_032808 | LINGO1 | -182858 | - | Essential tremor
pRE1-73 | chr16:88422513 | 0.531165395456757 | 8.916349580388008e-07 | rs1079556 | ND | NM_032451 | SPIRE2 | 105 | MCF10a
pRE1-74 | chr16:59634345 | 0.1009857856625321 | 0.0006193809300567132 | rs62047917 | ND | NM_001796 | CDH8 | 993895 | - | Non small cell lung cancer
pRE1-75 | chr19:56617234 | 0.1765454255322745 | 3.076491390273989e-06 | rs10405072 | ND | NM_033130 | SIGLEC10 | -3971 | -
pRE1-76 | chr19:45318825 | 0.3652225503196881 | 1.35422161200395e-07 | rs12461190 | - | [NAME] | [NAME] | -30140 | -
pRE1-77 | chr2:77135761 | -0.0718454146534595 | 0.003756669676174564 | rs57715014 | ND | NM_024993 | [NAME] | 464741 | -
pRE1-78 | chr21:42269254 | 0.1020472711484215 | 0.0002913823392722744 | rs34532428 | ND | NM_015500 | C2CD2 | -22186 | -
pRE1-79 | chr4:26728358 | 0.5547951851405141 | 7.722377463835944e-08 | rs16878854 | CEU* | NM_020860 | STIM2 | 256947 | -
pRE1-80 | chr6:89304738 | 0.008624880303275684 | 0.1225093247258697 | rs7742156 | CEU* | NM_016083 | CNR1 | -392935 | - | Obesity, bipolar disorder, depression, heroin addiction
pRE1-81 | chr6:89250020 | 0.01518863922065927 | 0.1146270865592054 | rs62430860 | ND | NM_016083 | CNR1 | -338217 | - | Obesity, bipolar disorder, depression, heroin addiction
pRE1-82 | chr9:130021147 | 0.3185509000570182 | 2.204951772516385e-05 | rs36009729 | ND | NM_001005336 | [NAME] | 15663 | - | Nicotine dependence