Spreadsheet: ae674426-373d-43d5-9bd1-50dce2fc2e53
Sheet: Sheet1

Name | Description | [NAME] GeneID | Log ratio in aggregated dataset | Rank in aggregated dataset | Amout of regulators, derived from analysis of up-regulated genes, regulating gene's expression | Amout of regulators, derived from analysis of down-regulated genes, regulating gene's expression | Ariadne DiseasesFX | [NAME] (Ariadne DiseasesFX) | Available in Biofluids (Ariadne DiseasesFX) | Secreted (Ariadne DiseasesFX) | Inflammation | Fibrosis | Regeneration | Muscle-related | Energy Metabolism related | Obesity | Osteoporosis | Angiogenesis | Dilated Cardiomyopathy | Cardiac Diseases | Glucocorticoids/NR3C1 | GO Biological Process | GO Molecular Function
MYH3 | [NAME], heavy chain 3, skeletal muscle, embryonic | 4621 | 5.687202 | 20 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | - | - | [NAME]-based movement, muscle organ development, striated muscle contraction | nucleotide binding, ATP binding, [NAME], [NAME], motor activity, microfilament motor activity
[NAME] | [NAME], heavy chain 8, skeletal muscle, perinatal | 4626 | 4.160488 | 19 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | - | - | biological_process, striated muscle contraction | molecular_function, nucleotide binding, ATP binding, [NAME], [NAME], motor activity, structural constituent of muscle
ACTC1 | [NAME], alpha, cardiac muscle 1 | 70 | 3.40126 | 13 | 0 | 0 | + | + | - | - | - | - | - | - | - | - | - | - | + | - | - | cardiac myofibril assembly, muscle thin filament assembly, actin filament-based movement, actomyosin structure organization, apoptosis, cardiac muscle tissue morphogenesis, heart contraction, cardiac muscle contraction, response to drug, response to ethanol | protein binding, nucleotide binding, ATP binding, [NAME], ATPase activity
PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 5320 | 3.001097 | 133 | 6 | 0 | + | - | + | + | + | + | - | - | - | + | - | - | - | - | + | negative regulation of cell proliferation, somatic stem cell maintenance, negative regulation of epithelial cell proliferation, positive regulation of foam cell differentiation, positive regulation of inflammatory response, regulation of cell proliferation, regulation of epithelial cell proliferation, low-density lipoprotein particle remodeling, phospholipid metabolic process, phosphatidic acid metabolic process <more data available...> | calcium ion binding, phospholipid binding, hydrolase activity, phospholipase A2 activity, calcium-dependent phospholipase A2 activity
MYBPH | [NAME] binding protein H | 4608 | 2.865126 | 38 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | - | - | cell adhesion, regulation of striated muscle contraction, striated muscle contraction | protein binding, structural constituent of muscle
MYL4 | [NAME], light chain 4, alkali; atrial, embryonic | 4635 | 2.622774 | 33 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | - | - | regulation of the force of heart contraction, positive regulation of ATPase activity, muscle organ development, cardiac muscle contraction | calcium ion binding, actin filament binding, [NAME] binding, [NAME] heavy chain binding, motor activity, structural constituent of muscle
TNNT2 | troponin T type 2 (cardiac) | 7139 | 2.553952 | 100 | 2 | 2 | + | + | + | - | + | + | - | + | - | + | - | + | + | + | - | sarcomere organization, protein heterooligomerization, regulation of muscle contraction, regulation of heart contraction, negative regulation of ATPase activity, positive regulation of ATPase activity, actin crosslink formation, muscle filament sliding, atrial cardiac muscle morphogenesis, ventricular cardiac muscle morphogenesis <more data available...> | protein binding, bridging, actin binding, tropomyosin binding, troponin C binding, troponin I binding, structural constituent of cytoskeleton
LYZ | lysozyme | 4069 | 2.543096 | 23 | 5 | 2 | + | - | + | + | + | + | - | - | + | + | - | + | - | - | + | metabolic process, cytolysis, cell wall macromolecule catabolic process, defense response to bacterium, defense response to Gram-positive bacterium, defense response to Gram-negative bacterium, inflammatory response | catalytic activity, protein binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, lysozyme activity
C1QA | complement component 1, q subcomponent, A chain | 712 | 2.457634 | 2 | 1 | 1 | + | - | + | + | + | - | - | - | + | + | - | - | - | - | - | biological_process, complement activation, classical pathway, cell-cell signaling, immune response, innate immune response | molecular_function
[NAME] | prune homolog 2 (Drosophila) | 158471 | 2.454521 | 83 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | induction of apoptosis, [NAME] phase, apoptosis | metal ion binding, transition metal ion binding, manganese ion binding, oxidoreductase activity
TNC | tenascin C | 3371 | 2.446281 | 292 | 16 | 1 | + | - | + | + | + | + | + | + | - | + | - | + | + | - | + | cell adhesion, signal transduction, neuromuscular junction development, response to wounding | protein binding, fibronectin binding, receptor binding
CHRNA1 | [NAME], nicotinic, alpha 1 (muscle) | 1134 | 2.436217 | 34 | 0 | 1 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | signal transduction, muscle maintenance, neuron maintenance, regulation of membrane potential, regulation of action potential in neuron, neuromuscular synaptic transmission, neuromuscular junction development, skeletal muscle tissue growth, transport, ion transport <more data available...> | acetylcholine binding, acetylcholine receptor activity, neurotransmitter receptor activity, receptor activity, ion channel activity, nicotinic acetylcholine-activated cation-selective channel activity, extracellular ligand-gated ion channel activity
FKBP5 | FK506 binding protein 5 | 2289 | -2.431278 | 107 | 0 | 0 | + | - | - | - | + | - | - | - | - | - | - | - | - | - | + | protein folding | binding, protein binding, FK506 binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity
COL1A2 | collagen, type I, alpha 2 | 1278 | 2.399304 | 41 | 23 | 4 | + | - | - | + | - | - | - | - | - | - | + | - | - | - | - | [NAME] receptor [NAME] signaling pathway, transforming growth factor beta receptor signaling pathway, Rho protein signal transduction, regulation of blood pressure, collagen fibril organization, odontogenesis, skin morphogenesis, blood vessel development, skeletal system development | protein binding, identical protein binding, [NAME] binding, protein binding, bridging, platelet-derived growth factor binding, extracellular matrix structural constituent
SLC47A1 | solute carrier family 47, member 1 | 55244 | -2.352217 | 66 | 0 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | multidrug transport, transport | drug transporter activity, antiporter activity
[NAME] | lumican | 4060 | 2.342475 | 46 | 3 | 0 | + | - | - | + | + | + | - | - | - | - | - | - | - | - | - | collagen fibril organization, visual perception | protein binding, collagen binding, extracellular matrix structural constituent
TMEM52 | [NAME] 52 | 339456 | -2.342204 | 12 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
TYROBP | TYRO protein tyrosine kinase binding protein | 7305 | 2.293082 | 15 | 2 | 0 | + | - | + | + | + | - | - | - | - | + | - | - | - | - | - | intracellular signaling cascade, cellular defense response | protein binding, kinase activity, receptor signaling protein activity
TUBA1A | tubulin, alpha 1a | 7846 | 2.269667 | 24 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | protein polymerization, microtubule-based process, microtubule-based movement | structural molecule activity, nucleotide binding, GTP binding, protein domain specific binding, protein heterodimerization activity, GTPase activity
VCAN | versican | 1462 | 2.262041 | 29 | 8 | 1 | + | - | - | + | - | - | + | - | - | - | - | + | - | - | + | cell adhesion, cell motion, cell recognition, axon regeneration, SRP-dependent cotranslational protein targeting to membrane, multicellular organismal development, heart development, response to wounding | binding, sugar binding, hyaluronic acid binding, calcium ion binding, GTP binding, low-density lipoprotein binding
[NAME] | lymphocyte-specific protein 1 pseudogene | 654342 | 2.244243 | 31 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
TUBB6 | tubulin, beta 6 | 84617 | 2.202007 | 4 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | protein polymerization, microtubule-based process, microtubule-based movement | structural molecule activity, nucleotide binding, GTP binding, GTPase activity
COL5A2 | collagen, type V, alpha 2 | 1290 | 2.148482 | 51 | 1 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | collagen fibril organization, ossification, eye morphogenesis, skin development, skeletal system development | molecular_function, [NAME] binding, extracellular matrix structural constituent
[NAME] | runt-related transcription factor 1 | 861 | 2.113525 | 7 | 4 | 0 | + | - | - | + | - | + | - | + | - | - | - | + | - | - | + | positive regulation of angiogenesis, positive regulation of granulocyte differentiation, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, regulation of transcription, DNA-dependent, neuron development, neuron differentiation, multicellular organismal development, liver development, embryonic hemopoiesis <more data available...> | protein binding, chloride ion binding, DNA binding, transcription factor activity, ATP binding, transcription activator activity
TIMP1 | TIMP metallopeptidase inhibitor 1 | 7076 | 2.079193 | 3 | 27 | 3 | + | + | + | + | + | + | + | - | - | + | - | + | + | + | + | negative regulation of apoptosis, negative regulation of membrane protein ectodomain proteolysis, positive regulation of cell proliferation, erythrocyte maturation, C21-steroid hormone biosynthetic process, cell activation, aging, cartilage development, response to organic substance, response to cytokine stimulus <more data available...> | protein binding, enzyme inhibitor activity, metalloendopeptidase inhibitor activity
COL3A1 | collagen, type III, alpha 1 | 1281 | 2.065837 | 56 | 14 | 3 | + | - | + | + | - | + | - | - | - | + | - | + | - | - | - | cell-matrix adhesion, negative regulation of immune response, integrin-mediated signaling pathway, transforming growth factor beta receptor signaling pathway, platelet activation, collagen fibril organization, fibril organization, peptide cross-linking, heart development, gut development <more data available...> | protein binding, [NAME] binding, platelet-derived growth factor binding, [NAME], extracellular matrix structural constituent
ASPN | asporin | 54829 | 2.064479 | 39 | 2 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - |  | protein binding
PENK | proenkephalin | 5179 | 2.03979 | 10 | 11 | 0 | + | - | + | + | + | - | - | - | + | + | - | + | - | - | + | signal transduction, neuropeptide signaling pathway, behavioral fear response, sensory perception of pain, behavior | opioid peptide activity, neuropeptide hormone activity
CAPN6 | calpain 6 | 827 | 2.036549 | 40 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | + | - | - | - | proteolysis | cysteine-type endopeptidase activity, calcium-dependent cysteine-type endopeptidase activity
MXRA5 | matrix-remodelling associated 5 | 25878 | 2.029967 | 27 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - |  | protein binding
MYL5 | [NAME], light chain 5, regulatory | 4636 | 2.002366 | 85 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | - | - | regulation of muscle contraction | calcium ion binding, motor activity, structural constituent of muscle
IL17B | interleukin 17B | 27190 | 2.000618 | 80 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | cell-cell signaling, neutrophil chemotaxis, immune response, inflammatory response | protein binding, receptor binding, cytokine activity, signal transducer activity
ART3 | ADP-ribosyltransferase 3 | 419 | -1.996689 | 6 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | + | protein amino acid ADP-ribosylation | transferase activity, transferase activity, transferring glycosyl groups, [NAME] ADP-ribosyltransferase activity, NAD+ ADP-ribosyltransferase activity
LGMN | legumain | 5641 | 1.995658 | 79 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | + | - | - | - | negative regulation of multicellular organism growth, proteolysis | hydrolase activity, peptidase activity, cysteine-type peptidase activity, cysteine-type endopeptidase activity, protein serine-threonine kinase activity
S100A4 | S100 calcium binding protein A4 | 6275 | 1.968478 | 28 | 7 | 0 | + | - | + | + | + | + | - | - | - | + | - | + | - | - | - | epithelial to mesenchymal transition | protein binding, calcium ion binding, calcium-dependent protein binding, identical protein binding, protein homodimerization activity, protein heterodimerization activity
APOC1 | apolipoprotein C-I | 341 | 1.962187 | 86 | 2 | 2 | + | - | + | + | - | - | - | - | + | + | - | - | - | - | - | very-low-density lipoprotein particle assembly, negative regulation of receptor-mediated endocytosis, negative regulation of fatty acid biosynthetic process, negative regulation of lipid catabolic process, negative regulation of cholesterol transport, positive regulation of cholesterol esterification, negative regulation of lipoprotein lipase activity, very-low-density lipoprotein particle clearance, high-density lipoprotein particle remodeling, cholesterol metabolic process <more data available...> | molecular_function, fatty acid binding, phosphatidylcholine binding, phosphatidylcholine-sterol O-acyltransferase activator activity, phospholipase inhibitor activity
CD14 | CD14 molecule | 929 | 1.960164 | 14 | 12 | 0 | + | - | + | + | + | + | - | - | - | + | - | + | - | - | + | cell surface receptor linked signal transduction, apoptosis, phagocytosis, immune response, response to molecule of bacterial origin, inflammatory response | protein binding, peptidoglycan receptor activity, opsonin receptor activity
SRPX | sushi-repeat-containing protein, X-linked | 8406 | 1.94259 | 67 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, cell adhesion | molecular_function, protein binding
PCOLCE | procollagen C-endopeptidase enhancer | 5118 | 1.906638 | 78 | 0 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | multicellular organismal development, proteolysis | protein binding
LAPTM5 | lysosomal protein transmembrane 5 | 7805 | 1.903828 | 26 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | transport
SH3BGRL3 | SH3 domain binding glutamic acid-rich protein like 3 | 83442 | 1.888534 | 48 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | cell redox homeostasis | electron carrier activity, protein disulfide oxidoreductase activity
OGN | osteoglycin | 4969 | 1.880555 | 92 | 6 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | biological_process | molecular_function, protein binding, growth factor activity
APOE | apolipoprotein E | 348 | 1.869618 | 178 | 12 | 2 | + | - | + | + | + | - | + | - | + | + | + | + | + | + | - | negative regulation of platelet activation, anti-apoptosis, negative regulation of blood vessel endothelial cell migration, negative regulation of endothelial cell proliferation, negative regulation of inflammatory response, induction of apoptosis, positive regulation of cGMP biosynthetic process, positive regulation of low-density lipoprotein receptor catabolic process, positive regulation of membrane protein ectodomain proteolysis, regulation of neuronal synaptic plasticity <more data available...> | antioxidant activity, lipid binding, heparin binding, metal chelating activity, phospholipid binding, beta-amyloid binding, lipoprotein binding, tau protein binding, protein homodimerization activity, protein heterodimerization activity <more data available...>
EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 23136 | 1.86693 | 5 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, cortical actin cytoskeleton organization | binding, structural molecule activity, cytoskeletal protein binding, actin binding
RNASE6 | ribonuclease, RNase A family, k6 | 6039 | 1.856982 | 18 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | RNA catabolic process, defense response | nucleic acid binding, hydrolase activity, nuclease activity, endonuclease activity, ribonuclease activity, pancreatic ribonuclease activity
F13A1 | coagulation factor [NAME], [NAME] polypeptide | 2162 | 1.846202 | 128 | 3 | 0 | + | - | + | + | - | - | - | - | - | + | - | + | - | - | - | blood coagulation, peptide cross-linking, wound healing | metal ion binding, calcium ion binding, transferase activity, acyltransferase activity, protein-glutamine gamma-glutamyltransferase activity
MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | 64231 | 1.8272 | 1 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | signal transduction | receptor activity
S100A11 | S100 calcium binding protein A11 | 6282 | 1.8264 | 43 | 0 | 0 | + | - | - | + | + | - | - | - | - | - | - | - | - | - | - | negative regulation of cell proliferation, negative regulation of DNA replication, signal transduction | calcium ion binding, calcium-dependent protein binding, S100 beta binding, protein homodimerization activity
CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 1009 | 1.775532 | 242 | 1 | 0 | + | - | - | + | - | - | - | + | - | - | - | - | - | - | - | cell adhesion, cell-cell adhesion, homophilic cell adhesion, ossification, skeletal system development | protein binding, calcium ion binding
MEST | mesoderm specific transcript homolog (mouse) | 4232 | 1.77225 | 170 | 0 | 0 | + | - | + | - | - | - | - | - | - | + | - | - | - | - | - | mesoderm development, response to retinoic acid | catalytic activity, protein binding
DCLK1 | doublecortin-like kinase 1 | 9201 | 1.765727 | 8 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | intracellular signaling cascade, neuron migration, axonogenesis, dendrite morphogenesis, axon extension, central nervous system projection neuron axonogenesis, cell differentiation, endosome transport, protein amino acid phosphorylation, multicellular organismal development <more data available...> | protein binding, nucleotide binding, ATP binding, transferase activity, kinase activity, protein kinase activity, protein serine-threonine kinase activity, receptor signaling protein activity
POSTN | periostin, osteoblast specific factor | 10631 | 1.759388 | 443 | 5 | 0 | + | - | + | + | - | + | - | - | - | + | - | + | - | - | - | cell adhesion, extracellular matrix organization, tissue development, skeletal system development | protein binding, heparin binding
ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 2065 | 1.725462 | 273 | 0 | 1 | + | - | - | + | - | - | - | - | - | - | - | + | - | - | - | negative regulation of cell adhesion, negative regulation of signal transduction, negative regulation of neuron apoptosis, negative regulation of secretion, positive regulation of phosphoinositide 3-kinase cascade, positive regulation of glucose import, regulation of cell proliferation, transmembrane receptor [NAME] signaling pathway, axonogenesis, [NAME] cell differentiation <more data available...> | protein binding, nucleotide binding, ATP binding, growth factor binding, protein homodimerization activity, protein heterodimerization activity, transferase activity, kinase activity, protein kinase activity, protein tyrosine kinase activity <more data available...>
MGP | matrix [NAME] protein | 4256 | 1.722882 | 140 | 7 | 0 | + | - | + | + | - | - | - | - | - | + | + | + | - | - | - | protein complex assembly, cartilage condensation, regulation of bone mineralization, cell differentiation, multicellular organismal development, ossification, branching morphogenesis of a tube, lung development, cartilage development, sensory perception of sound <more data available...> | calcium ion binding, calcium-dependent protein binding, structural constituent of bone, extracellular matrix structural constituent
DAB2 | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 1601 | 1.712345 | 37 | 3 | 0 | + | - | - | + | + | - | - | - | - | - | - | - | - | - | - | negative regulation of cell growth, cell proliferation, cell morphogenesis involved in differentiation, pinocytosis, receptor-mediated endocytosis, in utero embryonic development, excretion | protein binding, protein C-terminus binding
GPNMB | glycoprotein (transmembrane) nmb | 10457 | 1.687059 | 55 | 3 | 0 | + | - | - | + | + | + | - | - | - | - | - | - | - | - | - | cell adhesion, negative regulation of cell proliferation, osteoblast differentiation, bone mineralization | heparin binding, [NAME]
VCAM1 | vascular cell adhesion molecule 1 | 7412 | 1.68008 | 58 | 23 | 5 | + | - | + | + | + | - | - | + | + | + | - | + | - | - | + | cell adhesion, cell-cell adhesion, [NAME] adhesion, heterophilic cell adhesion, [NAME] or rolling, positive regulation of T cell proliferation, B cell differentiation, membrane to membrane docking, interspecies interaction between organisms | protein binding, cell adhesion molecule binding, [NAME]
HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | 3115 | 1.623969 | 68 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | + | - | - | immune response, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
HLA-DRA | major histocompatibility complex, class II, DR alpha | 3122 | 1.621847 | 45 | 7 | 2 | + | - | + | - | - | - | - | - | - | + | - | - | - | - | - | positive regulation of immune response, antigen processing and presentation, immune response, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, antigen processing and presentation of exogenous peptide antigen via MHC class II, immunoglobulin mediated immune response, defense response | MHC class II receptor activity
COL6A3 | collagen, type VI, alpha 3 | 1293 | 1.581325 | 70 | 0 | 0 | + | + | - | + | - | - | - | - | - | - | - | + | - | - | - | cell adhesion, muscle organ development | protein binding, serine-type endopeptidase inhibitor activity
COL14A1 | collagen, type XIV, alpha 1 | 7373 | 1.574008 | 190 | 1 | 0 | + | - | + | - | - | - | - | + | - | + | - | - | - | - | - | cell adhesion, cell-cell adhesion, collagen fibril organization | structural molecule activity, protein binding, protein binding, bridging, collagen binding, extracellular matrix structural constituent
S100A6 | S100 calcium binding protein A6 | 6277 | 1.573665 | 210 | 3 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | positive regulation of fibroblast proliferation, signal transduction, cell cycle, cell proliferation, axonogenesis | protein binding, calcium ion binding, zinc ion binding, calcium-dependent protein binding, S100 beta binding, protein homodimerization activity, growth factor activity, ion transmembrane transporter activity
GADD45A | growth arrest and DNA-damage-inducible, alpha | 1647 | 1.573015 | 216 | 10 | 1 | + | - | - | - | + | - | - | - | + | - | - | - | - | - | - | regulation of cell cycle, regulation of cyclin-dependent protein kinase activity, negative regulation of protein kinase activity, cell cycle, cell cycle arrest, G2-M transition of mitotic cell cycle, centrosome cycle, apoptosis, DNA repair, response to DNA damage stimulus | protein binding
HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 3113 | 1.56703 | 124 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | antigen processing and presentation, immune response, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | MHC class II receptor activity
IFI16 | interferon, gamma-inducible protein 16 | 3428 | 1.56598 | 91 | 3 | 1 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, regulation of transcription, DNA-dependent, cell proliferation, myeloid cell differentiation, [NAME] differentiation, transcription, response to virus | protein binding, DNA binding, double-stranded DNA binding, transcription repressor activity
AQP4 | aquaporin 4 | 361 | -1.563015 | 235 | 1 | 0 | + | + | + | + | - | - | + | - | - | + | - | - | - | - | - | protein homooligomerization, water homeostasis, nervous system development, transport, water transport, excretion | transporter activity, water transporter activity, water channel activity, porin activity
TSPAN8 | tetraspanin 8 | 7103 | -1.560982 | 602 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | + | - | - | - | negative regulation of blood coagulation, protein amino acid glycosylation | signal transducer activity
C20orf166 | chromosome 20 open reading frame 166 | 128826 | -1.558779 | 127 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
[NAME] | complement component 3 | 718 | 1.556652 | 88 | 3 | 1 | + | + | + | + | + | - | - | - | + | + | - | - | - | - | - | positive regulation of phagocytosis, positive regulation of type IIa hypersensitivity, complement activation, complement activation, alternative pathway, complement activation, classical pathway, signal transduction, G-protein coupled receptor protein signaling pathway, blood coagulation, immune response, innate immune response <more data available...> | molecular_function, protein binding, cofactor binding, receptor binding, endopeptidase inhibitor activity
AHNAK2 | AHNAK nucleoprotein 2 | 113146 | 1.555931 | 144 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | keratinization | protein binding, nucleic acid binding
SAT1 | spermidine/spermine N1-acetyltransferase 1 | 6303 | 1.547235 | 9 | 3 | 0 | + | - | + | - | + | - | - | - | + | + | - | - | - | - | - | metabolic process, regulation of cell proliferation, spermine catabolic process, polyamine metabolic process | spermidine binding, transferase activity, acyltransferase activity, N-acetyltransferase activity, diamine N-acetyltransferase activity
SAMD4A | sterile alpha motif domain containing 4A | 23034 | -1.546917 | 104 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | positive regulation of translation | translation repressor activity
RPL3 | ribosomal protein L3 | 6122 | 1.533074 | 47 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, translation, translational elongation | molecular_function, protein binding, RNA binding, structural constituent of ribosome
UCP3 | uncoupling protein 3 (mitochondrial, proton carrier) | 7352 | -1.510774 | 214 | 0 | 16 | + | - | + | + | + | - | - | - | + | + | - | - | - | - | + | mitochondrial transport, fatty acid metabolic process, transport, proton transport, lipid metabolic process, respiratory gaseous exchange, response to superoxide, response to hypoxia | binding, transporter activity, hydrogen ion transmembrane transporter activity, oxidative phosphorylation uncoupler activity
EMP3 | epithelial membrane protein 3 | 2014 | 1.498585 | 150 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | negative regulation of cell proliferation, cell growth
CLIC4 | chloride intracellular channel 4 | 25932 | 1.49604 | 36 | 2 | 0 | + | - | - | - | - | - | - | - | - | - | - | + | - | - | - | negative regulation of cell migration, cell differentiation, transport, ion transport, chloride transport | protein binding, chloride ion binding, protein complex binding, ion channel activity, chloride channel activity, voltage-gated chloride channel activity, voltage-gated ion channel activity
MYOF | myoferlin | 26509 | 1.487219 | 89 | 0 | 0 | NA | NA | NA | NA | - | - | - | - | - | - | - | - | - | - | -
CLIC1 | chloride intracellular channel 1 | 1192 | 1.481509 | 60 | 1 | 0 | + | - | + | - | - | - | - | - | - | + | - | - | - | - | - | signal transduction, transport, ion transport, chloride transport, response to unfolded protein, response to nutrient, defense response | protein binding, chloride ion binding, NF-kappaB binding, ion channel activity, chloride channel activity, voltage-gated chloride channel activity, voltage-gated ion channel activity
SFRP4 | secreted frizzled-related protein 4 | 6424 | 1.474596 | 227 | 1 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | signal transduction, Wnt receptor signaling pathway, cell differentiation, multicellular organismal development, embryo implantation | protein binding
ADSSL1 | adenylosuccinate synthase like 1 | 122622 | -1.472016 | 166 | 1 | 1 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | immune system process, purine nucleotide metabolic process, AMP biosynthetic process, purine nucleotide biosynthetic process | protein binding, nucleotide binding, phosphate binding, metal ion binding, magnesium ion binding, GTP binding, ligase activity, adenylosuccinate synthase activity
[NAME] | Thy-1 cell surface antigen | 7070 | 1.471912 | 138 | 0 | 0 | + | - | + | + | + | - | - | - | - | + | - | - | - | - | - | angiogenesis, focal adhesion formation, cell-cell adhesion, negative regulation of T cell receptor signaling pathway, negative regulation of apoptosis, negative regulation of axonogenesis, negative regulation of cell migration, negative regulation of fibroblast proliferation, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of T cell activation <more data available...> | protein binding, GPI anchor binding, enzyme binding, [NAME], Rho GTPase activator activity
PYCARD | PYD and CARD domain containing | 29108 | 1.471862 | 109 | 0 | 0 | + | - | + | + | + | - | + | - | - | + | - | - | - | - | - | negative regulation of cell cycle, induction of apoptosis, positive regulation of interleukin-1 beta secretion, signal transduction, regulation of apoptosis, regulation of caspase activity, activation of caspase activity, positive regulation of NF-kappaB transcription factor activity, tumor necrosis factor-mediated signaling pathway, cell cycle <more data available...> | protein binding, protein homodimerization activity, Pyrin domain binding, cysteine-type endopeptidase activity, caspase activator activity, apoptotic protease activator activity
ARPC1B | [NAME] related protein 2/3 complex, subunit 1B, 41kDa | 10095 | 1.467788 | 143 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of actin filament polymerization, cell motion | protein binding, actin binding, structural constituent of cytoskeleton
HIST1H1C | histone cluster 1, H1c | 3006 | -1.466049 | 274 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | nucleosome assembly, nucleosome positioning | protein binding, DNA binding
HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | 3119 | 1.465328 | 165 | 2 | 0 | + | - | - | + | - | - | - | - | + | - | - | - | + | - | - | immune response, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | MHC class II receptor activity
RPL3P7 | ribosomal protein L3 pseudogene 7 | 642741 | 1.461251 | 30 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
IGFBP4 | insulin-like growth factor binding protein 4 | 3487 | 1.458178 | 116 | 6 | 4 | + | - | + | + | + | - | + | + | - | + | - | + | - | - | - | signal transduction, regulation of cell growth, intracellular signaling cascade, cell proliferation, DNA metabolic process, skeletal system development, inflammatory response | growth factor binding, insulin-like growth factor binding
WWTR1 | WW domain containing transcription regulator 1 | 25937 | 1.455597 | 63 | 1 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | negative regulation of fat cell differentiation, negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, cilium morphogenesis, osteoblast differentiation, transcription, glomerulus development | transcription regulator activity, protein binding, protein homodimerization activity, transcription coactivator activity, transcription corepressor activity
MYLK2 | [NAME] chain kinase 2 | 85366 | -1.45127 | 160 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | positive regulation of cell motion, positive regulation of fast-twitch skeletal muscle fiber contraction, regulation of cell cycle, regulation of muscle filament sliding, regulation of MAPKKK cascade, regulation of neuronal synaptic plasticity, regulation of muscle contraction, neuromuscular synaptic transmission, peptidyl-serine phosphorylation, protein amino acid phosphorylation <more data available...> | nucleotide binding, ATP binding, [NAME], [NAME] light chain binding, transferase activity, kinase activity, protein kinase activity, protein serine-threonine kinase activity, [NAME] chain kinase activity, calmodulin-dependent protein kinase activity
COL16A1 | collagen, type XVI, alpha 1 | 1307 | 1.450811 | 269 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | cell adhesion, integrin-mediated signaling pathway, female pregnancy | structural molecule activity, protein binding, [NAME]
PEBP4 | phosphatidylethanolamine-binding protein 4 | 157310 | -1.443956 | 447 | 0 | 0 | NA | NA | NA | NA | - | - | - | - | - | - | - | - | - | - | -
OLFML2B | olfactomedin-like 2B | 25903 | 1.435785 | 25 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | extracellular matrix organization | extracellular matrix binding, protein homodimerization activity
[NAME] | [NAME] specific transcript 1 | 7940 | 1.422947 | 236 | 3 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | negative regulation of lymphocyte proliferation, regulation of cell shape, dendrite development, cell morphogenesis, anatomical structure morphogenesis, immune response | molecular_function, protein binding
[NAME] | calponin 3, acidic | 1266 | 1.419849 | 238 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | actomyosin structure organization, smooth muscle contraction | protein binding, [NAME], protein binding, bridging, actin binding, tropomyosin binding, troponin C binding, microtubule binding
COL6A1 | collagen, type VI, alpha 1 | 1291 | 1.415927 | 255 | 1 | 1 | + | + | - | + | - | + | - | - | - | - | - | - | - | - | - | biological_process, cell adhesion | molecular_function, protein binding, platelet-derived growth factor binding
TPPP3 | tubulin polymerization-promoting protein family member 3 | 51673 | 1.412662 | 321 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -
S100A13 | S100 calcium binding protein A13 | 6284 | 1.412186 | 181 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | cell differentiation | calcium ion binding
CFH | complement factor H | 3075 | 1.407406 | 123 | 1 | 0 | + | - | + | + | + | - | - | - | + | + | - | - | - | - | - | complement activation, complement activation, alternative pathway, regulation of complement activation, immune response, innate immune response | protein binding, heparin binding, eukaryotic cell surface binding, zinc ion binding, complement component [NAME] binding
HMGN1 | high-mobility group nucleosome binding domain 1 | 3150 | 1.406903 | 95 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | - | - |  | DNA binding, RNA polymerase II transcription factor activity, positive transcription elongation factor activity
HTRA1 | HtrA serine peptidase 1 | 5654 | 1.404192 | 61 | 0 | 0 | + | + | - | + | - | - | - | - | - | - | - | - | - | - | - | negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of BMP signaling pathway, regulation of cell growth, proteolysis | catalytic activity, protein binding, growth factor binding, insulin-like growth factor binding, hydrolase activity, peptidase activity, serine-type peptidase activity, serine-type endopeptidase activity
CHAF1B | chromatin assembly factor 1, subunit B (p60) | 8208 | -1.402768 | 247 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | DNA replication-dependent nucleosome assembly, protein complex assembly, regulation of transcription, DNA-dependent, cell cycle, DNA replication, transcription, DNA repair, response to DNA damage stimulus | chromatin binding, histone binding, unfolded protein binding
CCND2 | cyclin D2 | 894 | 1.398534 | 136 | 10 | 2 | + | - | - | - | - | - | + | - | - | - | - | - | - | - | + | positive regulation of cell proliferation, positive regulation of cyclin-dependent protein kinase activity, positive regulation of epithelial cell proliferation, positive regulation of protein amino acid phosphorylation, regulation of cell cycle, regulation of neuron differentiation, cell cycle, cell division, [NAME] transition of mitotic cell cycle, cellular response to insulin stimulus <more data available...> | protein binding, protein kinase binding
GPR137B | G protein-coupled receptor 137B | 7107 | 1.394481 | 176 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process | molecular_function
SLC7A7 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 | 9056 | 1.389835 | 57 | 1 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, protein complex assembly, amino acid metabolic process, transport, amino acid transport | molecular_function, amino acid transmembrane transporter activity
KIAA0101 | KIAA0101 | 9768 | 1.384747 | 258 | 1 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
FAP | fibroblast activation protein, alpha | 2191 | 1.380868 | 309 | 2 | 0 | + | - | - | + | - | + | - | - | - | - | - | - | - | - | - | proteolysis | protein homodimerization activity, hydrolase activity, peptidase activity, serine-type peptidase activity, metalloendopeptidase activity, serine-type endopeptidase activity, dipeptidyl-peptidase activity
NID2 | nidogen 2 (osteonidogen) | 22795 | 1.376082 | 106 | 0 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | cell adhesion, cell-matrix adhesion, bioluminescence, protein-chromophore linkage | protein binding, calcium ion binding, collagen binding
CRIP1 | cysteine-rich protein 1 (intestinal) | 1396 | 1.37446 | 267 | 0 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | + | cell proliferation | metal ion binding, zinc ion binding
TMSB10 | thymosin beta 10 | 9168 | 1.373928 | 71 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | + | - | - | - | sequestering of actin monomers, actin cytoskeleton organization | [NAME] binding
UPK3A | uroplakin 3A | 7380 | -1.373408 | 276 | 0 | 0 | + | - | + | - | - | - | - | - | - | + | - | - | - | - | - | potassium ion homeostasis, sodium ion homeostasis, cell morphogenesis, epithelial cell differentiation, kidney development, urinary bladder development, urea transport, water transport
CASQ2 | calsequestrin 2 (cardiac muscle) | 845 | 1.373003 | 217 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | + | - | biological_process, regulation of muscle contraction, heart development, striated muscle contraction | molecular_function, calcium ion binding
S100A10 | S100 calcium binding protein A10 | 6281 | 1.371111 | 164 | 0 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | signal transduction, regulation of cell growth, regulation of cell differentiation | protein binding, calcium ion binding, receptor binding
FN1 | fibronectin 1 | 2335 | 1.357821 | 359 | 21 | 5 | + | - | + | + | + | + | + | + | + | + | + | + | - | + | + | cell-substrate junction assembly, cell adhesion, cell-matrix adhesion, anti-apoptosis, regulation of cell shape, transmembrane receptor [NAME] signaling pathway, cell migration, extracellular matrix organization, peptide cross-linking, ossification <more data available...> | protein binding, heparin binding, mercury ion binding, collagen binding, protease binding, peptidase activator activity, extracellular matrix structural constituent
[NAME] | cat eye syndrome chromosome region, candidate 1 | 51816 | 1.353261 | 75 | 0 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | purine ribonucleoside monophosphate biosynthetic process, multicellular organismal development | growth factor activity, hydrolase activity, deaminase activity
BGN | biglycan | 633 | 1.348658 | 35 | 10 | 1 | + | + | + | + | + | + | - | - | - | + | - | - | - | - | - | biological_process, peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan, blood vessel remodeling | protein binding, extracellular matrix binding, glycosaminoglycan binding, extracellular matrix structural constituent
COL6A2 | collagen, type VI, alpha 2 | 1292 | 1.343984 | 234 | 1 | 0 | + | + | - | - | - | - | - | - | - | - | - | - | - | - | - | cell adhesion, cell-cell adhesion, extracellular matrix organization, response to glucose stimulus | molecular_function, protein binding, protein binding, bridging, extracellular matrix structural constituent
COTL1 | coactosin-like 1 (Dictyostelium) | 23406 | 1.342178 | 32 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, defense response to fungus | protein binding, enzyme binding, actin binding
LSP1 | lymphocyte-specific protein 1 | 4046 | 1.33696 | 93 | 0 | 0 | + | - | - | - | + | + | - | - | - | - | - | - | - | - | - | signal transduction, cell motion, apoptosis, cytoskeleton organization, chemotaxis, defense response, cellular defense response | [NAME], signal transducer activity
C8orf22 | chromosome 8 open reading frame 22 | 492307 | -1.33285 | 524 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
MARCKS | myristoylated alanine-rich protein kinase C substrate | 4082 | 1.331919 | 119 | 0 | 0 | + | - | - | + | - | - | - | - | + | - | - | - | - | - | - |  | [NAME], [NAME], actin filament binding, protein kinase C binding
HNMT | histamine N-methyltransferase | 3176 | 1.331191 | 62 | 0 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | regulation of neurotransmitter levels, respiratory gaseous exchange | transferase activity, methyltransferase activity, N-methyltransferase activity, histamine N-methyltransferase activity
UBE2D1 | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) | 7321 | -1.328159 | 99 | 2 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | positive regulation of protein ubiquitination, BMP signaling pathway, regulation of protein metabolic process, negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle, modification-dependent protein catabolic process, ubiquitin-dependent protein catabolic process, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, post-translational protein modification, protein polyubiquitination | ligase activity, small conjugating protein ligase activity, ubiquitin-protein ligase activity
SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 6678 | 1.327427 | 135 | 5 | 2 | + | - | + | + | + | + | - | - | - | + | + | + | - | - | - | signal transduction, regulation of cell proliferation, transmembrane receptor [NAME] signaling pathway, ossification, inner ear development, heart development, lung development, response to lipopolysaccharide, response to gravity, response to cytokine stimulus <more data available...> | extracellular matrix binding, calcium ion binding, copper ion binding, collagen binding
COL5A1 | collagen, type V, alpha 1 | 1289 | 1.326169 | 102 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, cell adhesion, regulation of cellular component organization, wound healing, spreading of epidermal cells, collagen fibril organization, fibril organization, integrin biosynthetic process, heart morphogenesis, eye morphogenesis, skin development <more data available...> | structural molecule activity, protein binding, heparin binding, proteoglycan binding, platelet-derived growth factor binding, [NAME], extracellular matrix structural constituent
CTSK | cathepsin K | 1513 | 1.324079 | 49 | 9 | 0 | + | - | + | + | + | + | - | - | - | + | + | - | - | + | - | bone resorption, intramembranous ossification, proteolysis | protein binding, hydrolase activity, peptidase activity, cysteine-type peptidase activity, cysteine-type endopeptidase activity
TGFBI | transforming growth factor, beta-induced, 68kDa | 7045 | 1.32004 | 239 | 7 | 0 | + | - | + | + | + | - | + | - | - | + | - | + | - | - | - | response to stimulus, cell adhesion, negative regulation of cell adhesion, cell proliferation, extracellular matrix organization, visual perception | protein binding, extracellular matrix binding, [NAME]
RAD23A | RAD23 homolog A (S. cerevisiae) | 5886 | -1.315194 | 16 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | proteasomal ubiquitin-dependent protein catabolic process, protein modification process, DNA repair, nucleotide-excision repair, interspecies interaction between organisms, response to DNA damage stimulus | protein binding, damaged DNA binding, single-stranded DNA binding
FAT1 | FAT tumor suppressor homolog 1 (Drosophila) | 2195 | 1.308619 | 39 | 0 | 0 | NA | NA | NA | NA | - | - | - | - | - | - | - | - | - | - | - | cell adhesion, cell-cell adhesion, homophilic cell adhesion, establishment or maintenance of cell polarity, actin filament organization, cell-cell signaling, anatomical structure morphogenesis | protein binding, calcium ion binding
PRMT2 | [NAME] 2 | 3275 | 1.306275 | 224 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | signal transduction, protein amino acid methylation | identical protein binding, transferase activity, methyltransferase activity, signal transducer activity
TP53I3 | tumor protein p53 inducible protein 3 | 9540 | 1.305338 | 77 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | induction of apoptosis by oxidative stress, oxidation reduction | binding, zinc ion binding, oxidoreductase activity
TUBA1B | tubulin, alpha 1b | 10376 | 1.3046 | 65 | 1 | 0 | + | + | + | + | - | - | - | - | - | + | - | - | - | - | - | protein polymerization, microtubule-based process, microtubule cytoskeleton organization, microtubule-based movement | structural molecule activity, nucleotide binding, GTP binding, GTPase activity, structural constituent of cytoskeleton
PHTF2 | putative homeodomain transcription factor 2 | 57157 | -1.304121 | 101 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of transcription, DNA-dependent, transcription | DNA binding
CXCL12 | chemokine (C-X-C motif) ligand 12 | 6387 | 1.29975 | 113 | 5 | 1 | + | - | + | + | + | + | + | + | + | + | - | + | - | - | - | patterning of blood vessels, cell adhesion, positive regulation of cell proliferation, positive regulation of neuron differentiation, positive regulation of axon extension involved in axon guidance, positive regulation of cell migration, positive regulation of endothelial cell proliferation, induction of positive chemotaxis, positive regulation of dopamine secretion, positive regulation of calcium ion transport via voltage-gated calcium channel activity <more data available...> | growth factor activity, cytokine activity, chemokine activity, signal transducer activity
LRRC20 | leucine rich repeat containing 20 | 55222 | -1.297401 | 82 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - |  | protein binding
CMYA5 | cardiomyopathy associated 5 | 202333 | -1.29561 | 421 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | + | - |  | identical protein binding
MN1 | meningioma (disrupted in balanced translocation) 1 | 4330 | -1.291868 | 17 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, negative regulation of cell cycle, intramembranous ossification | molecular_function
SNX7 | sorting nexin 7 | 51375 | 1.290635 | 152 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | cell communication, transport, protein transport | protein binding, phosphoinositide binding
FHL3 | four and a half LIM domains 3 | 2275 | -1.28711 | 42 | 0 | 0 | + | - | - | - | - | - | + | + | - | - | - | - | - | - | - | actin cytoskeleton organization, muscle organ development | metal ion binding, zinc ion binding, actin binding
EVI2B | ecotropic viral integration site 2B | 2124 | 1.278565 | 310 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
PGAM2 | phosphoglycerate mutase 2 (muscle) | 5224 | -1.27783 | 148 | 0 | 0 | + | + | - | - | - | - | - | - | - | - | - | - | - | - | - | metabolic process, gluconeogenesis, glycolysis, striated muscle contraction, spermatogenesis, response to inorganic substance, response to mercury ion | catalytic activity, cofactor binding, hydrolase activity, isomerase activity, 2,3-bisphospho-D-glycerate 2-phosphohydrolase activity, intramolecular transferase activity, phosphotransferases, phosphoglycerate mutase activity, bisphosphoglycerate mutase activity, 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 5255 | -1.273208 | 129 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | generation of precursor metabolites and energy, phosphatidylcholine biosynthetic process, glycogen metabolic process, protein amino acid autophosphorylation, carbohydrate metabolic process | catalytic activity, [NAME], transferase activity, kinase activity, phosphorylase kinase activity, choline-phosphate cytidylyltransferase activity
UGCG | UDP-glucose ceramide glucosyltransferase | 7357 | 1.272685 | 253 | 1 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | glycosphingolipid biosynthetic process, glucosylceramide biosynthetic process, epidermis development | molecular_function, transferase activity, transferase activity, transferring glycosyl groups, ceramide glucosyltransferase activity
FNDC5 | fibronectin type III domain containing 5 | 252995 | -1.2675 | 371 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process | protein binding
LOXL1 | lysyl oxidase-like 1 | 4016 | 1.265263 | 149 | 0 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | protein amino acid deamination, oxidation reduction | protein binding, metal ion binding, copper ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor, protein-lysine 6-oxidase activity
CCDC109B | coiled-coil domain containing 109B | 55013 | 1.264617 | 72 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
COLEC12 | collectin sub-family member 12 | 81035 | 1.263703 | 54 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | protein homooligomerization, carbohydrate mediated signaling, phagocytosis, recognition, immune response, innate immune response | binding, sugar binding, galactose binding, metal ion binding, calcium ion binding, low-density lipoprotein binding, receptor activity, pattern recognition receptor activity, scavenger receptor activity
SFXN3 | sideroflexin 3 | 81855 | 1.256931 | 248 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, transport, ion transport, cation transport, iron ion transport | molecular_function, iron ion binding, cation transmembrane transporter activity, tricarboxylate secondary active transmembrane transporter activity
LGALS3 | lectin, galactoside-binding, soluble, 3 | 3958 | 1.256818 | 146 | 7 | 0 | + | - | + | + | + | + | + | - | + | + | - | + | - | - | - | extracellular matrix organization, cell differentiation, skeletal system development | protein binding, sugar binding, IgE binding
PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 5156 | 1.254246 | 194 | 8 | 1 | + | - | + | + | - | + | - | - | - | + | - | + | - | - | - | positive regulation of cell proliferation, positive regulation of cell migration, positive regulation of fibroblast proliferation, positive regulation of DNA replication, transmembrane receptor [NAME] signaling pathway, platelet-derived growth factor receptor signaling pathway, cell activation, extracellular matrix organization, gliogenesis, peptidyl-tyrosine phosphorylation <more data available...> | nucleotide binding, ATP binding, protein dimerization activity, platelet-derived growth factor binding, protein homodimerization activity, protein heterodimerization activity, platelet-derived growth factor receptor binding, transferase activity, kinase activity, protein kinase activity <more data available...>
C1R | complement component 1, r subcomponent | 715 | 1.25137 | 81 | 1 | 1 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | biological_process, complement activation, classical pathway, immune response, innate immune response, proteolysis | molecular_function, catalytic activity, calcium ion binding, hydrolase activity, peptidase activity, serine-type peptidase activity, serine-type endopeptidase activity
DDAH2 | [NAME] 2 | 23564 | 1.251005 | 195 | 1 | 0 | + | - | + | - | + | - | - | - | - | + | - | + | - | - | - | anti-apoptosis, nitric oxide mediated signal transduction, arginine catabolic process, arginine metabolic process, nitric oxide biosynthetic process, response to unfolded protein, response to nutrient, defense response | protein binding, amino acid binding, NF-kappaB binding, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines, dimethylargininase activity
[NAME] | carboxypeptidase, vitellogenic-like | 54504 | 1.250881 | 157 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | proteolysis | hydrolase activity, peptidase activity, carboxypeptidase activity, serine-type carboxypeptidase activity
TUBB2A | tubulin, beta 2A | 7280 | 1.250289 | 251 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | protein polymerization, microtubule-based process, microtubule-based movement | structural molecule activity, protein binding, nucleotide binding, GTP binding, GTPase activity
HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 3123 | 1.239789 | 50 | 1 | 1 | + | - | - | + | - | + | - | - | - | - | - | - | + | + | + | antigen processing and presentation, immune response, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, antigen processing and presentation of exogenous peptide antigen via MHC class II | protein binding, MHC class II receptor activity
FBP2 | fructose-1,6-bisphosphatase 2 | 8789 | -1.23804 | 689 | 0 | 0 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | - | gluconeogenesis, fructose metabolic process, carbohydrate metabolic process | catalytic activity, metal ion binding, magnesium ion binding, hydrolase activity, phosphoric ester hydrolase activity, fructose 1,6-bisphosphate 1-phosphatase activity, fructose-2,6-bisphosphate 2-phosphatase activity
FGL2 | fibrinogen-like 2 | 10875 | 1.23606 | 291 | 3 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | signal transduction, cytolysis, parturition | receptor binding, peptidase activity
TMEM158 | [NAME] 158 (gene/pseudogene) | 25907 | 1.233134 | 114 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - |  | protein binding, peptide binding, receptor activity
SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 6542 | -1.231865 | 478 | 3 | 0 | + | - | + | - | + | - | - | - | - | + | - | - | - | - | - | regulation of inflammatory response, macrophage activation, amino acid metabolic process, nitric oxide biosynthetic process, transport, amino acid transport, L-amino acid transport, ornithine transport, arginine transport, lysine transport <more data available...> | amino acid transmembrane transporter activity, L-amino acid transmembrane transporter activity, basic amino acid transmembrane transporter activity, [NAME] transporter activity, L-lysine transmembrane transporter activity, high affinity arginine transmembrane transporter activity, L-ornithine transmembrane transporter activity
HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 3091 | 1.230951 | 328 | 17 | 6 | + | - | + | + | + | + | + | + | + | + | - | + | - | - | + | angiogenesis, positive regulation of angiogenesis, negative regulation of growth, positive regulation of cell proliferation, positive regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of erythrocyte differentiation, positive regulation of epithelial cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of endothelial cell proliferation, positive regulation of transcription <more data available...> | transcription regulator activity, protein binding, DNA binding, sequence-specific DNA binding, transcription factor activity, double-stranded DNA binding, RNA polymerase II transcription factor activity, enhancer binding, transcription factor binding, histone acetyltransferase binding, Hsp90 protein binding <more data available...>
[NAME] | vesicle-associated membrane protein 8 (endobrevin) | 8673 | 1.229586 | 44 | 1 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | protein complex assembly, vesicle-mediated transport, membrane fusion | protein binding
VIM | vimentin | 7431 | 1.227925 | 180 | 10 | 1 | + | - | + | + | - | - | + | + | + | + | - | + | - | - | - | biological_process, intermediate filament-based process, cell motion, interspecies interaction between organisms | structural molecule activity, protein binding, protein kinase binding, structural constituent of cytoskeleton
PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | 5502 | -1.224993 | 73 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | signal transduction, glycogen metabolic process, carbohydrate metabolic process | protein binding, phosphoprotein phosphatase inhibitor activity, protein serine-threonine phosphatase inhibitor activity
NCAM1 | neural cell adhesion molecule 1 | 4684 | 1.218762 | 118 | 6 | 1 | + | - | + | + | + | - | + | + | - | + | - | + | - | - | - | cell adhesion, homotypic cell-cell adhesion, calcium-independent cell-cell adhesion, positive regulation of calcium-mediated signaling, cell surface receptor linked signal transduction | protein binding, heparin binding, cytoskeletal protein binding, phosphatase binding, LRR domain binding, fibroblast growth factor receptor binding
RAB31 | RAB31, member RAS oncogene family | 11031 | 1.217867 | 22 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | small GTPase mediated signal transduction, protein transport | nucleotide binding, GTP binding, GTPase activity
PDLIM4 | PDZ and LIM domain 4 | 8572 | 1.217451 | 112 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | - | - |  | protein binding, metal ion binding, zinc ion binding
MAGED2 | melanoma antigen family D, 2 | 10916 | 1.208239 | 21 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process | molecular_function
CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, [NAME]) | 1026 | 1.207464 | 378 | 29 | 8 | + | - | + | + | + | + | + | + | + | + | - | + | - | - | + | negative regulation of cell proliferation, negative regulation of cell growth, negative regulation of cyclin-dependent protein kinase activity, negative regulation of apoptosis, positive regulation of anti-apoptosis, negative regulation of phosphorylation, positive regulation of B cell proliferation, positive regulation of programmed cell death, induction of apoptosis by intracellular signals, positive regulation of fibroblast proliferation <more data available...> | protein binding, metal ion binding, zinc ion binding, protein complex binding, cyclin binding, kinase activity, protein kinase inhibitor activity, cyclin-dependent protein kinase inhibitor activity
MT1X | metallothionein 1X | 4501 | -1.206868 | 895 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | response to metal ion | metal ion binding, cadmium ion binding, copper ion binding, zinc ion binding
FBN1 | fibrillin 1 | 2200 | 1.204759 | 383 | 2 | 0 | + | - | + | + | - | + | - | - | - | + | - | + | - | - | - | heart development, kidney development, skeletal system development | binding, protein binding, calcium ion binding, zinc ion binding, extracellular matrix structural constituent
NPC2 | Niemann-Pick disease, type C2 | 10577 | 1.202442 | 76 | 0 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | biological_process, regulation of isoprenoid metabolic process, cholesterol homeostasis, intracellular cholesterol transport, phospholipid transport, glycolipid transport | molecular_function, cholesterol binding, enzyme binding
ATP9A | ATPase, class II, type 9A | 10079 | 1.196657 | 192 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | metabolic process, ATP biosynthetic process, phospholipid transport | nucleotide binding, metal ion binding, magnesium ion binding, ATP binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, phospholipid-translocating ATPase activity
LMOD1 | leiomodin 1 (smooth muscle) | 25802 | -1.195346 | 737 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |  | tropomyosin binding
ZBTB16 | zinc finger and BTB domain containing 16 | 7704 | -1.19074 | 369 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | negative regulation of cell proliferation, negative regulation of myeloid cell differentiation, negative regulation of transcription, DNA-dependent, negative regulation of transcription from RNA polymerase II promoter, positive regulation of apoptosis, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, apoptosis, male germ-line stem cell division, transcription <more data available...> | protein binding, nucleic acid binding, metal ion binding, zinc ion binding, DNA binding, transcription factor activity, double-stranded DNA binding, protein C-terminus binding, protein homodimerization activity, transcription activator activity <more data available...>
LY96 | [NAME] 96 | 23643 | 1.188731 | 59 | 2 | 0 | + | - | + | + | + | - | - | - | - | + | - | - | - | - | - | cell surface receptor linked signal transduction, I-kappaB kinase-NF-kappaB cascade, immune response, inflammatory response, cellular defense response | protein binding, coreceptor activity
JAM3 | junctional adhesion molecule 3 | 83700 | 1.188519 | 159 | 0 | 0 | + | - | - | - | + | - | - | - | - | - | - | + | - | - | - | cell adhesion | protein binding
IL10RA | interleukin 10 receptor, alpha | 3587 | 1.18779 | 111 | 1 | 0 | + | - | - | + | + | + | - | - | - | - | - | + | - | - | + |  | protein binding, cytokine receptor activity, interleukin-10 receptor activity, receptor activity
SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 710 | 1.187163 | 121 | 3 | 0 | + | - | + | + | + | - | - | - | - | + | - | - | - | - | - | biological_process, negative regulation of complement activation, [NAME], complement activation, classical pathway, blood coagulation, immune response, innate immune response, blood circulation | molecular_function, complement binding, endopeptidase inhibitor activity, serine-type endopeptidase inhibitor activity
ANXA5 | annexin A5 | 308 | 1.185269 | 132 | 0 | 0 | + | - | + | + | + | - | - | - | - | + | - | - | - | - | - | protein homooligomerization, anti-apoptosis, negative regulation of coagulation, signal transduction, blood coagulation, response to organic substance | protein binding, eukaryotic cell surface binding, calcium ion binding, calcium-dependent phospholipid binding, receptor [NAME] binding, phospholipase inhibitor activity
ADCY7 | adenylate cyclase 7 | 113 | 1.185179 | 218 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | signal transduction, activation of adenylate cyclase activity, intracellular signaling cascade, cyclic nucleotide biosynthetic process, cAMP biosynthetic process | metal ion binding, magnesium ion binding, lyase activity, adenylate cyclase activity, phosphorus-oxygen lyase activity
CTSS | cathepsin S | 1520 | 1.183503 | 161 | 5 | 0 | + | - | + | + | + | + | - | - | - | + | - | + | - | - | - | immune response, proteolysis | hydrolase activity, peptidase activity, cysteine-type peptidase activity, cysteine-type endopeptidase activity
KCTD12 | potassium channel tetramerisation domain containing 12 | 115207 | 1.182908 | 221 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | potassium ion transport | protein binding, voltage-gated potassium channel activity
AHR | [NAME] receptor | 196 | 1.177777 | 332 | 6 | 0 | + | - | + | + | + | + | + | - | + | + | - | + | - | - | + | positive regulation of transcriptional preinitiation complex assembly, positive regulation of transcription, DNA-dependent, signal transduction, regulation of transcription, regulation of transcription, DNA-dependent, cell cycle, apoptosis, xenobiotic metabolic process, transcription, transcription from RNA polymerase II promoter <more data available...> | transcription regulator activity, DNA binding, transcription factor activity, transcription factor binding, Hsp90 protein binding, protein heterodimerization activity, signal transducer activity, receptor activity, ligand-dependent nuclear receptor activity, [NAME] receptor activity
TUBA1C | tubulin, alpha 1c | 84790 | 1.17515 | 52 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | protein polymerization, microtubule-based process, microtubule-based movement | structural molecule activity, protein binding, nucleotide binding, GTP binding, GTPase activity
SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 | 23380 | 1.17074 | 357 | 0 | 0 | + | - | - | - | - | - | + | - | - | - | - | - | - | - | - | signal transduction | protein binding, GTPase activator activity
RHOBTB1 | Rho-related BTB domain containing 1 | 9886 | -1.164244 | 442 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | small GTPase mediated signal transduction | protein binding, nucleotide binding, GTP binding
EZR | ezrin | 7430 | 1.158763 | 290 | 2 | 1 | + | - | + | + | - | - | - | - | - | + | - | + | - | - | - | actin filament bundle formation, [NAME] adhesion, regulation of cell shape, cytoskeletal anchoring at plasma membrane, establishment or maintenance of apical-basal cell polarity, epithelial cell differentiation, membrane to membrane docking | binding, structural molecule activity, protein binding, protein self-association, cell adhesion molecule binding, cytoskeletal protein binding, actin filament binding
NDUFV3 | NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa | 4731 | -1.158127 | 183 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | electron transport chain, mitochondrial electron transport, NADH to ubiquinone, transport | molecular_function, NADH dehydrogenase (ubiquinone) activity
IL1R1 | interleukin 1 receptor, type I | 3554 | 1.155472 | 240 | 9 | 1 | + | - | + | + | + | + | - | + | + | + | - | + | - | + | + | signal transduction, cell surface receptor linked signal transduction, cytokine-mediated signaling pathway, innate immune response | protein binding, interleukin-1 receptor activity, interleukin-1, Type I, activating receptor activity, platelet-derived growth factor receptor binding, signal transducer activity, receptor activity, transmembrane receptor activity
C14orf139 | chromosome 14 open reading frame 139 | 79686 | 1.154261 | 96 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
RPL3L | ribosomal protein L3-like | 6123 | -1.148317 | 167 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | translation, translational elongation | RNA binding, structural constituent of ribosome
CALD1 | caldesmon 1 | 800 | 1.14811 | 418 | 1 | 0 | + | - | + | - | - | + | - | + | - | + | - | - | - | - | + | cell motion, muscle contraction | [NAME], [NAME], [NAME], tropomyosin binding
PNPLA4 | patatin-like phospholipase domain containing 4 | 8228 | -1.141742 | 712 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | metabolic process, lipid catabolic process | molecular_function, hydrolase activity, triacylglycerol lipase activity
[NAME] | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa | 4716 | -1.137724 | 397 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, electron transport chain, mitochondrial electron transport, NADH to ubiquinone, transport | molecular_function, protein binding, NADH dehydrogenase (ubiquinone) activity
IFI30 | interferon, gamma-inducible protein 30 | 10437 | 1.133158 | 94 | 1 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | negative regulation of fibroblast proliferation, protein stabilization, antigen processing and presentation of exogenous peptide antigen via MHC class II, oxidation reduction | oxidoreductase activity, disulfide oxidoreductase activity
PLAU | plasminogen activator, urokinase | 5328 | 1.132427 | 105 | 15 | 2 | + | + | + | + | + | + | + | + | + | + | - | + | - | - | + | angiogenesis, fibrinolysis, signal transduction, regulation of cell proliferation, blood coagulation, smooth muscle cell migration, embryo implantation, blood vessel morphogenesis, skeletal muscle regeneration, chemotaxis <more data available...> | hydrolase activity, peptidase activity, serine-type peptidase activity, serine-type endopeptidase activity, kinase activity
PPIB | peptidylprolyl isomerase B (cyclophilin B) | 5479 | 1.127924 | 300 | 0 | 0 | + | - | + | + | + | - | - | - | - | + | - | - | - | - | - | nuclear transport, protein folding | peptide binding, unfolded protein binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity
BASP1 | brain abundant, membrane attached signal protein 1 | 10409 | 1.121826 | 145 | 0 | 0 | + | - | + | - | - | - | + | - | - | + | - | - | - | - | - |  | [NAME]
CYFIP1 | cytoplasmic FMR1 interacting protein 1 | 23191 | 1.118311 | 230 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | lamellipodium assembly, regulation of cell shape, ruffle organization, axon extension, cell differentiation, multicellular organismal development, nervous system development | protein binding, profilin binding, [NAME], actin filament binding, [NAME] binding
SCN1B | sodium channel, voltage-gated, type I, beta | 6324 | -1.115808 | 53 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | synaptic transmission, transport, ion transport, sodium ion transport | sodium ion binding, ion channel activity, sodium channel activity, voltage-gated sodium channel activity, voltage-gated ion channel activity
CMTM6 | CKLF-like MARVEL transmembrane domain containing 6 | 54918 | 1.112146 | 64 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | chemotaxis | cytokine activity
DMXL2 | Dmx-like 2 | 23312 | 1.108719 | 156 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process | Rab GTPase binding
NDN | necdin homolog (mouse) | 4692 | 1.107423 | 270 | 0 | 0 | + | - | - | - | - | - | + | + | + | - | - | - | - | - | - | regulation of growth, negative regulation of cell proliferation, regulation of cell growth, regulation of transcription, DNA-dependent, nerve growth factor receptor signaling pathway, cellular calcium ion homeostasis, glial cell migration, neuron migration, axonal fasciculation, axonogenesis <more data available...> | protein binding, DNA binding, protein C-terminus binding, receptor binding, gamma-tubulin binding, protein homodimerization activity
HN1 | hematological and neurological expressed 1 | 51155 | 1.106138 | 155 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | biological_process | molecular_function
PPP1R16A | protein phosphatase 1, regulatory (inhibitor) subunit 16A | 84988 | -1.099512 | 934 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - |  | protein binding
C9orf23 | chromosome 9 open reading frame 23 | 138716 | -1.099189 | 546 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |  | nucleic acid binding
FTL | ferritin, light polypeptide | 2512 | 1.095064 | 108 | 0 | 1 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | cellular iron ion homeostasis, iron ion transport | molecular_function, binding, metal ion binding, transition metal ion binding, iron ion binding, ferric iron binding, identical protein binding, oxidoreductase activity
PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 5207 | -1.09281 | 231 | 1 | 2 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | + | metabolic process, positive regulation of glucokinase activity, protein kinase cascade, gluconeogenesis, glycolysis, fructose metabolic process, fructose 2,6-bisphosphate metabolic process, carbohydrate phosphorylation, organ regeneration, response to glucagon stimulus <more data available...> | catalytic activity, nucleotide binding, fructose-6-phosphate binding, ATP binding, identical protein binding, kinase binding, hydrolase activity, transferase activity, fructose-2,6-bisphosphate 2-phosphatase activity, kinase activity <more data available...>
SEPP1 | selenoprotein P, plasma, 1 | 6414 | 1.090073 | 346 | 2 | 2 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | + | growth, selenium metabolic process, post-embryonic development, brain development, sexual reproduction, locomotory behavior, response to oxidative stress, response to selenium ion | selenium binding
CA2 | carbonic anhydrase II | 760 | -1.088311 | 268 | 3 | 1 | + | - | + | + | - | - | + | - | - | + | - | - | - | - | - | positive regulation of cellular pH reduction, positive regulation of osteoclast differentiation, positive regulation of bone resorption, regulation of bone resorption, regulation of cellular pH, osteoclast differentiation, one-carbon compound metabolic process, odontogenesis of dentine-containing tooth, morphogenesis of an epithelium, kidney development <more data available...> | protein binding, metal ion binding, zinc ion binding, lyase activity, carbonate dehydratase activity
RAP2B | RAP2B, member of RAS oncogene family | 5912 | 1.087267 | 266 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | signal transduction, small GTPase mediated signal transduction | nucleotide binding, GTP binding, protein domain specific binding
CHCHD10 | coiled-coil-helix-coiled-coil-helix domain containing 10 | 400916 | -1.082552 | 209 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -
LAMA4 | laminin, alpha 4 | 3910 | 1.081764 | 339 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | + | + | - | - | cell adhesion, regulation of cell adhesion, regulation of cell migration, regulation of embryonic development, brown fat cell differentiation, blood vessel development | protein binding, receptor binding, extracellular matrix structural constituent
CSF1R | colony stimulating factor 1 receptor | 1436 | 1.080936 | 110 | 11 | 1 | + | - | + | + | + | + | - | - | + | + | - | + | - | - | + | positive regulation of osteoclast differentiation, signal transduction, transmembrane receptor [NAME] signaling pathway, cell proliferation, protein amino acid phosphorylation, multicellular organismal development, skeletal muscle tissue development | molecular_function, protein binding, nucleotide binding, ATP binding, cytokine binding, protein homodimerization activity, transferase activity, kinase activity, protein kinase activity, protein tyrosine kinase activity <more data available...>
TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 7048 | 1.078344 | 120 | 5 | 3 | + | - | + | + | + | + | - | - | - | + | - | + | - | - | + | patterning of blood vessels, trachea formation, negative regulation of cell proliferation, negative regulation of cardiac muscle cell proliferation, positive regulation of NK T cell differentiation, positive regulation of mesenchymal cell proliferation, positive regulation of smooth muscle cell proliferation, positive regulation of skeletal muscle regeneration, positive regulation of T cell tolerance induction, positive regulation of tolerance induction to self antigen <more data available...> | protein binding, nucleotide binding, glycosaminoglycan binding, metal ion binding, manganese ion binding, magnesium ion binding, ATP binding, [NAME] binding, transforming growth factor beta binding, mitogen-activated protein kinase kinase kinase binding <more data available...>
GRN | granulin | 2896 | 1.075555 | 115 | 2 | 0 | + | - | + | + | + | - | - | - | - | + | - | + | - | - | - | positive regulation of epithelial cell proliferation, signal transduction, embryo implantation, blastocyst hatching | growth factor activity, cytokine activity
OPTN | optineurin | 10133 | -1.073876 | 174 | 1 | 0 | + | - | - | + | - | - | - | - | - | - | - | + | - | - | - | signal transduction, cell death, Golgi organization, cellular protein localization, Golgi to plasma membrane protein transport, protein targeting to Golgi | protein binding, protein C-terminus binding
PLAGL1 | pleiomorphic adenoma gene-like 1 | 5325 | 1.072232 | 211 | 2 | 0 | + | - | + | - | - | - | - | - | - | + | - | - | - | - | - | induction of apoptosis, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, cell cycle arrest, transcription | protein binding, metal ion binding, zinc ion binding, DNA binding
PGM1 | phosphoglucomutase 1 | 5236 | -1.072118 | 175 | 0 | 0 | + | - | + | - | - | - | - | - | + | + | - | - | - | - | - | cellular calcium ion homeostasis, glucose metabolic process, carbohydrate metabolic process, response to radiation | molecular_function, metal ion binding, magnesium ion binding, isomerase activity, intramolecular transferase activity, phosphotransferases, phosphoglucomutase activity
SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | 10560 | -1.070972 | 835 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, G-protein coupled receptor protein signaling pathway, thiamin and derivative metabolic process, transport, [NAME], sensory perception of sound | molecular_function, folic acid binding, folic acid transporter activity, [NAME] transporter activity, reduced folate carrier activity
TIMP2 | TIMP metallopeptidase inhibitor 2 | 7077 | 1.069506 | 225 | 13 | 2 | + | + | + | + | + | + | + | - | - | + | + | + | - | + | - | negative regulation of cell proliferation, negative regulation of [NAME] protein signal transduction, negative regulation of mitotic cell cycle, negative regulation of proteolysis, positive regulation of MAPKKK cascade, positive regulation of neuron differentiation, regulation of MAPKKK cascade, regulation of Rap protein signal transduction, regulation of neuron differentiation, positive regulation of adenylate cyclase activity <more data available...> | protein binding, [NAME], enzyme activator activity, enzyme inhibitor activity, metalloendopeptidase inhibitor activity
GKAP1 | G kinase anchoring protein 1 | 80318 | -1.06908 | 392 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | signal transduction, G-protein signaling, coupled to cGMP nucleotide second messenger | protein binding
LRRC2 | leucine rich repeat containing 2 | 79442 | -1.06133 | 275 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - |  | protein binding
ACTG1 | [NAME], gamma 1 | 71 | 1.058086 | 141 | 2 | 1 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | sarcomere organization, cell motion, sensory perception of sound, response to calcium ion | molecular_function, protein binding, nucleotide binding, ATP binding, identical protein binding, structural constituent of cytoskeleton
XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | 7518 | 1.053454 | 422 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | negative regulation of neuron apoptosis, positive regulation of neurogenesis, positive regulation of fibroblast proliferation, positive regulation of ligase activity, isotype switching, T cell differentiation in the thymus, pro-B cell differentiation, DNA repair, DNA recombination, DNA ligation <more data available...> | protein binding, DNA binding, protein C-terminus binding, ligase activity
WBP5 | WW domain binding protein 5 | 51186 | 1.052994 | 172 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process | protein binding, WW domain binding
RORC | RAR-related orphan receptor C | 6097 | -1.051456 | 476 | 2 | 0 | + | - | - | + | + | - | - | - | + | - | - | - | - | - | - | regulation of transcription, DNA-dependent, T cell differentiation in the thymus, alpha-beta T cell differentiation, cell differentiation, transcription, protein amino acid phosphorylation, lymph node development, mucosal-associated lymphoid tissue development | metal ion binding, zinc ion binding, DNA binding, sequence-specific DNA binding, transcription factor activity, receptor activity, ligand-dependent nuclear receptor activity, steroid hormone receptor activity
PABPC1 | poly(A) binding protein, cytoplasmic 1 | 26986 | 1.05053 | 177 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | mRNA stabilization, mRNA processing, mRNA polyadenylation, RNA splicing | nucleic acid binding, nucleotide binding, RNA binding, mRNA binding, poly(A) binding, translation activator activity, protein C-terminus binding
TMOD4 | [NAME] (muscle) | 29765 | -1.047478 | 241 | 0 | 0 | - | - | - | - | - | - | - | + | - | - | - | - | - | - | - | muscle contraction | [NAME], tropomyosin binding
LMO1 | LIM domain only 1 (rhombotin 1) | 4004 | -1.045458 | 496 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of transcription, DNA-dependent, cell proliferation, transcription, multicellular organismal development | metal ion binding, zinc ion binding, transcription factor activity
FAM46A | family with sequence similarity 46, member A | 55603 | 1.044581 | 313 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
DHRS7C | dehydrogenase/reductase (SDR family) member 7C | 201140 | -1.044109 | 794 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -
CD302 | CD302 molecule | 9936 | 1.042893 | 184 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - |  | binding, sugar binding
PPP1R3C | protein phosphatase 1, regulatory (inhibitor) subunit 3C | 5507 | -1.040682 | 882 | 0 | 0 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | - | regulation of glycogen biosynthetic process, regulation of glycogen catabolic process, protein targeting, glycogen biosynthetic process, glycogen metabolic process, carbohydrate metabolic process | protein binding, enzyme binding, phosphoprotein phosphatase activity, protein serine-threonine phosphatase activity
C6orf136 | chromosome 6 open reading frame 136 | 221545 | -1.038877 | 344 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -
PHKG1 | phosphorylase kinase, gamma 1 (muscle) | 5260 | -1.036658 | 1067 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | glycogen biosynthetic process, glycogen metabolic process, protein amino acid phosphorylation, carbohydrate metabolic process | nucleotide binding, ATP binding, [NAME], enzyme binding, transferase activity, kinase activity, protein kinase activity, protein serine-threonine kinase activity, phosphorylase kinase activity
PDE4D | phosphodiesterase 4D, cAMP-specific | 5144 | -1.035658 | 281 | 2 | 0 | + | - | + | + | + | - | - | + | + | + | + | - | - | - | - | signal transduction, regulation of G-protein coupled receptor protein signaling pathway, cAMP catabolic process, smooth muscle contraction, memory | catalytic activity, metal ion binding, hydrolase activity, cyclic-nucleotide phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, 3',5'-cyclic-AMP phosphodiesterase activity
NRAP | nebulin-related anchoring protein | 4892 | -1.035348 | 1284 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | - | - | biological_process, actin cytoskeleton organization | protein binding, metal ion binding, zinc ion binding, actin binding, vinculin binding, muscle alpha-actinin binding
SLC25A12 | solute carrier family 25 (mitochondrial carrier, Aralar), member 12 | 8604 | -1.035163 | 464 | 0 | 0 | + | - | - | + | - | - | - | - | + | - | - | - | - | - | - | malate-aspartate shuttle, transport, aspartate transport, L-glutamate transport, response to calcium ion | binding, transporter activity, protein binding, calcium ion binding, L-aspartate transmembrane transporter activity, L-glutamate transmembrane transporter activity
RNF123 | ring finger protein 123 | 63891 | -1.035103 | 90 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, modification-dependent protein catabolic process | molecular_function, protein binding, metal ion binding, zinc ion binding, ligase activity
PLXDC1 | plexin domain containing 1 | 57125 | 1.034038 | 335 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | angiogenesis | molecular_function
ZEB2 | zinc finger E-box binding homeobox 2 | 9839 | 1.030619 | 280 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, neural tube closure, negative regulation of transcription, positive regulation of Wnt receptor signaling pathway, positive regulation of JUN kinase activity, regulation of transcription, DNA-dependent, neural crest cell migration, cell proliferation in forebrain, transcription, hippocampus development <more data available...> | molecular_function, transcription regulator activity, nucleic acid binding, metal ion binding, zinc ion binding, DNA binding, sequence-specific DNA binding, transcription factor activity, [NAME] binding, phosphatase regulator activity <more data available...>
CKAP4 | cytoskeleton-associated protein 4 | 10970 | 1.025938 | 213 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process | protein binding
IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 3613 | -1.020409 | 237 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | signal transduction, inositol metabolic process, phosphate metabolic process | metal ion binding, lithium ion binding, magnesium ion binding, hydrolase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1(or 4)-monophosphatase activity
PXDN | peroxidasin homolog (Drosophila) | 7837 | 1.016025 | 142 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | hydrogen peroxide catabolic process, immune response, oxidation reduction, response to oxidative stress | peroxidase activity, protein binding, metal ion binding, calcium ion binding, iron ion binding, heme binding, interleukin-1 receptor antagonist activity, oxidoreductase activity
ACADM | acyl-CoA dehydrogenase, [NAME] to C-12 straight chain | 34 | -1.012745 | 637 | 0 | 4 | + | - | + | - | + | - | - | - | + | + | - | - | - | - | + | metabolic process, cardiac muscle cell differentiation, organic acid metabolic process, [NAME] process, fatty acid beta-oxidation, fatty acid metabolic process, post-embryonic development, heart development, liver development, oxidation reduction <more data available...> | electron carrier activity, FAD binding, oxidoreductase activity, isomerase activity, oxidoreductase activity, acting on the CH-CH group of donors, acyl-CoA dehydrogenase activity
TCEA3 | transcription elongation factor A (SII), 3 | 6920 | -1.012691 | 226 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription, RNA elongation | transcription regulator activity, protein binding, nucleic acid binding, metal ion binding, zinc ion binding, DNA binding, translation elongation factor activity, transcription elongation regulator activity, RNA polymerase II transcription factor activity
HCLS1 | hematopoietic cell-specific [NAME] substrate 1 | 3059 | 1.011496 | 340 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | positive regulation of cell proliferation, positive regulation of tyrosine phosphorylation of STAT protein, regulation of transcription, DNA-dependent, intracellular signaling cascade, erythrocyte differentiation, response to hormone stimulus | protein binding, transcription factor activity, SH3 domain binding
NCF4 | neutrophil cytosolic factor 4, 40kDa | 4689 | 1.009269 | 254 | 0 | 0 | + | - | + | + | - | - | - | - | + | + | - | - | - | - | - | cell communication, immune response, oxidation reduction | protein binding, phosphoinositide binding, protein dimerization activity
MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 2872 | -1.008933 | 688 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of translation, cell surface receptor linked signal transduction, protein kinase cascade, protein amino acid phosphorylation, response to stress | protein binding, nucleotide binding, metal ion binding, zinc ion binding, magnesium ion binding, ATP binding, transferase activity, kinase activity, protein kinase activity, protein serine-threonine kinase activity
ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | 5244 | -1.007474 | 330 | 1 | 0 | + | - | + | + | - | + | - | - | - | + | - | - | - | - | - | transport, lipid metabolic process, response to drug, response to glucocorticoid stimulus | protein binding, nucleotide binding, ATP binding, hydrolase activity, ATPase activity, coupled to transmembrane movement of substances, xenobiotic-transporting ATPase activity, nucleoside-triphosphatase activity, ATPase activity
IGFBP7 | insulin-like growth factor binding protein 7 | 3490 | 1.005181 | 244 | 3 | 0 | + | - | + | + | - | - | - | - | - | + | - | + | - | - | + | cell adhesion, negative regulation of cell proliferation, regulation of cell growth, regulation of steroid biosynthetic process, cellular response to hormone stimulus, embryo implantation, response to heat, response to cortisol stimulus, response to retinoic acid, response to organic cyclic substance | molecular_function, growth factor binding, insulin-like growth factor binding
SH3BGRL | SH3 domain binding glutamic acid-rich protein like | 6451 | 1.002533 | 173 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process | molecular_function, SH3-SH2 adaptor activity, SH3 domain binding
OLFML2A | olfactomedin-like 2A | 169611 | 0.9972448 | 360 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | extracellular matrix organization | extracellular matrix binding, protein homodimerization activity
TRIM63 | tripartite motif-containing 63 | 84676 | -0.9965785 | 465 | 3 | 3 | + | + | - | - | - | - | - | + | + | - | - | - | - | - | + | signal transduction, modification-dependent protein catabolic process, proteasomal ubiquitin-dependent protein catabolic process, muscle contraction | protein binding, metal ion binding, zinc ion binding, [NAME], ligase activity, ubiquitin-protein ligase activity, signal transducer activity
MVP | major vault protein | 9961 | 0.996507 | 98 | 2 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | intracellular protein transmembrane transport, protein transport, mRNA transport, response to drug | protein binding
[NAME] | protein phosphatase 1, regulatory (inhibitor) subunit 3A | 5506 | -0.9957124 | 659 | 0 | 0 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | - | biological_process, glycogen metabolic process, carbohydrate metabolic process | molecular_function, protein serine-threonine phosphatase activity
ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 10096 | 0.9895481 | 222 | 0 | 0 | + | - | + | - | - | - | - | - | - | + | - | - | - | - | - | positive regulation of lamellipodium assembly, positive regulation of filopodium assembly, regulation of actin filament polymerization, positive regulation of actin filament polymerization, positive regulation of neuron differentiation, positive regulation of dendrite morphogenesis, regulation of myosin II filament assembly or disassembly, cell motion, response to antibiotic, response to protein stimulus <more data available...> | protein binding, nucleotide binding, ATP binding, actin binding
CXCR4 | chemokine (C-X-C motif) receptor 4 | 7852 | 0.9858736 | 368 | 16 | 0 | + | - | + | + | + | + | + | + | - | + | - | + | - | - | + | patterning of blood vessels, signal transduction, regulation of programmed cell death, regulation of cell migration, activation of MAPK activity, G-protein coupled receptor protein signaling pathway, regulation of calcium ion transport, regulation of chemotaxis, elevation of cytosolic calcium ion concentration, T cell proliferation <more data available...> | protein binding, C-X-C chemokine receptor activity, C-C chemokine receptor activity, [NAME], [NAME] light chain binding, signal transducer activity, receptor activity, coreceptor activity, G-protein coupled receptor activity
SEC24D | SEC24 family, member D (S. cerevisiae) | 9871 | 0.984475 | 168 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | vesicle-mediated transport, membrane organization, intracellular protein transport, ER to Golgi vesicle-mediated transport, transport, protein transport | molecular_function, protein binding, zinc ion binding
VDAC1 | voltage-dependent anion channel 1 | 7416 | -0.9819035 | 117 | 0 | 0 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | - | synaptic transmission, nerve-nerve synaptic transmission, apoptosis, mitochondrial calcium ion transport, transport, ion transport, anion transport, interspecies interaction between organisms, behavioral fear response, learning | protein binding, nucleotide binding, anion channel activity, voltage-gated anion channel activity
TUBB3 | tubulin, beta 3 | 10381 | 0.9800151 | 153 | 2 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | spindle assembly, protein polymerization, microtubule-based process, mitosis, neuron differentiation, microtubule-based movement | structural molecule activity, protein binding, nucleotide binding, GTP binding, MHC class I protein binding, GTPase activity, structural constituent of cytoskeleton
SAR1B | SAR1 homolog B (S. cerevisiae) | 51128 | -0.9722249 | 830 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, vesicle-mediated transport, membrane organization, intracellular protein transport, ER to Golgi vesicle-mediated transport, transport, protein transport | molecular_function, nucleotide binding, metal ion binding, magnesium ion binding, GTP binding
PYGM | phosphorylase, glycogen, muscle | 5837 | -0.9673011 | 103 | 0 | 0 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | - | cellular calcium ion homeostasis, glycogen metabolic process, glycogen catabolic process, carbohydrate metabolic process, response to organic substance, response to cAMP, response to hypoxia | catalytic activity, protein binding, nucleotide binding, drug binding, sugar binding, pyridoxal phosphate binding, AMP binding, protein homodimerization activity, transferase activity, transferase activity, transferring glycosyl groups <more data available...>
ERBB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | 2066 | -0.9665681 | 613 | 1 | 0 | + | - | + | + | - | - | - | - | + | + | - | + | + | - | - | positive regulation of anti-apoptosis, positive regulation of synaptic transmission, GABAergic, positive regulation of cell migration, positive regulation of epithelial cell proliferation, positive regulation of glucose import, signal transduction, transmembrane receptor [NAME] signaling pathway, surfactant homeostasis, cell proliferation, synapse maturation <more data available...> | protein binding, nucleotide binding, ATP binding, protein heterodimerization activity, transferase activity, kinase activity, protein kinase activity, protein tyrosine kinase activity, transmembrane receptor [NAME] activity, receptor activity
ARPC5 | [NAME] related protein 2/3 complex, subunit 5, 16kDa | 10092 | 0.96245 | 74 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of actin filament polymerization, cell motion, actin cytoskeleton organization | protein binding, actin binding, structural constituent of cytoskeleton
SULF1 | sulfatase 1 | 23213 | 0.9602403 | 403 | 1 | 0 | + | - | - | + | - | - | - | - | - | - | - | + | - | - | - | metabolic process, apoptosis, [NAME] process, heparan sulfate proteoglycan metabolic process | catalytic activity, metal ion binding, calcium ion binding, hydrolase activity, sulfuric ester hydrolase activity, alkyl sulfatase activity, arylsulfatase activity, N-acetylglucosamine-6-sulfatase activity
TBC1D4 | TBC1 domain family, member 4 | 9882 | -0.9591703 | 203 | 0 | 0 | + | - | - | + | - | - | - | - | + | - | - | - | - | - | - | regulation of Rab GTPase activity | GTPase activator activity, Rab GTPase activator activity
TRIP10 | thyroid hormone receptor interactor 10 | 9322 | -0.956052 | 122 | 0 | 0 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | - | signal transduction, actin cytoskeleton organization, endocytosis, hyperosmotic salinity response | protein binding, lipid binding, identical protein binding
IFFO1 | intermediate filament family orphan 1 | 25900 | 0.9522336 | 69 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
DTNA | dystrobrevin, alpha | 1837 | -0.9480224 | 723 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | + | - | signal transduction, neuromuscular synaptic transmission, striated muscle contraction | protein binding, metal ion binding, calcium ion binding, zinc ion binding
TPSB2 | tryptase beta 2 (gene/pseudogene) | 64499 | 0.94624 | 379 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | proteolysis, inflammatory response | protein binding, heparin binding, hydrolase activity, peptidase activity, serine-type peptidase activity, serine-type endopeptidase activity
ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | 217 | -0.942503 | 316 | 0 | 1 | + | - | - | - | - | + | - | - | + | - | - | - | - | - | - | metabolic process, cellular alcohol metabolic process, cellular response to hormone stimulus, liver development, oxidation reduction, carbohydrate metabolic process, response to progesterone stimulus, response to testosterone stimulus, response to nicotine, response to hyperoxia | molecular_function, electron carrier activity, identical protein binding, oxidoreductase activity, aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity
PRKCQ | protein kinase C, theta | 5588 | -0.9408487 | 212 | 1 | 0 | + | - | - | + | + | - | - | - | - | + | - | - | - | - | - | positive regulation of stress fiber formation, positive regulation of filopodium assembly, positive regulation of T cell activation, positive regulation of T cell proliferation, positive regulation of interleukin-2 biosynthetic process, positive regulation of NF-kappaB import into nucleus, positive regulation of protein secretion, regulation of cell growth, regulation of G2-M transition of mitotic cell cycle, positive regulation of NF-kappaB transcription factor activity <more data available...> | protein binding, nucleotide binding, metal ion binding, zinc ion binding, magnesium ion binding, diacylglycerol binding, ATP binding, transferase activity, kinase activity, protein kinase activity <more data available...>
CAMK2G | calcium/calmodulin-dependent protein kinase II gamma | 818 | -0.9386625 | 202 | 1 | 0 | + | - | - | + | - | - | - | + | + | - | - | - | - | - | - | regulation of long-term neuronal synaptic plasticity, insulin secretion, [NAME] transition of mitotic cell cycle, protein amino acid phosphorylation, protein amino acid autophosphorylation, calcium ion transport, response to oxidative stress, response to hypoxia | nucleotide binding, ATP binding, [NAME], transferase activity, calcium-dependent protein serine-threonine phosphatase activity, kinase activity, protein kinase activity, protein serine-threonine kinase activity, calmodulin-dependent protein kinase activity
PLN | phospholamban | 5350 | -0.9366985 | 456 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | + | + | - | negative regulation of heart contraction, regulation of calcium ion transport, regulation of the force of heart contraction, cellular calcium ion homeostasis, cardiac muscle tissue development, blood circulation | calcium channel regulator activity, protein binding, ATPase inhibitor activity
GLUL | glutamate-ammonia ligase | 2752 | -0.9240395 | 728 | 3 | 1 | + | - | + | + | - | + | - | - | - | + | - | - | - | - | + | glutamine biosynthetic process, nitrogen compound metabolic process, response to glucose stimulus | catalytic activity, ligase activity, glutamate-ammonia ligase activity
PPT1 | palmitoyl-protein thioesterase 1 | 5538 | 0.923888 | 193 | 0 | 0 | + | - | - | + | - | - | + | - | - | - | - | - | - | - | - | response to stimulus, negative regulation of cell growth, negative regulation of neuron apoptosis, positive regulation of pinocytosis, positive regulation of receptor-mediated endocytosis, regulation of synaptic plasticity, regulation of synapse structure and activity, lysosomal lumen acidification, neurotransmitter secretion, regulation of phospholipase A2 activity <more data available...> | hydrolase activity, palmitoyl-(protein) hydrolase activity, palmitoyl-CoA hydrolase activity
LPPR4 | lipid phosphate phosphatase-related protein type 4 | 9890 | 0.9238422 | 171 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | axonogenesis, phospholipid dephosphorylation | catalytic activity, hydrolase activity, lipid phosphatase activity, phosphatidate phosphatase activity
TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 25816 | 0.9234643 | 284 | 1 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | negative regulation of anti-apoptosis, apoptosis | protein binding, caspase inhibitor activity
AMPD1 | adenosine monophosphate deaminase 1 | 270 | -0.9207188 | 370 | 1 | 2 | + | + | + | - | - | - | - | + | - | + | - | - | - | + | - | purine base metabolic process, nucleotide metabolic process, purine ribonucleoside monophosphate biosynthetic process, response to organic substance | protein binding, hydrolase activity, deaminase activity, AMP deaminase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
WLS | wntless homolog (Drosophila) | 79971 | 0.917545 | 286 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - |  | - | - | -
P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 8974 | 0.9133277 | 163 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | peptidyl-proline hydroxylation to 4-hydroxy-L-proline, oxidation reduction, protein metabolic process | electron carrier activity, binding, protein binding, metal ion binding, iron ion binding, L-ascorbic acid binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, procollagen-proline 4-dioxygenase activity
[NAME] | dual specificity phosphatase 13 | 51207 | -0.9103321 | 718 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | - | - | meiosis, protein amino acid dephosphorylation, dephosphorylation, spermatogenesis | hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine-serine-threonine phosphatase activity
BTG3 | BTG family, member 3 | 10950 | 0.9063971 | 372 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | negative regulation of cell proliferation, negative regulation of mitotic cell cycle, response to oxidative stress | protein binding
MRPL27 | mitochondrial ribosomal protein L27 | 51264 | -0.9047786 | 570 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | translation | structural constituent of ribosome
[NAME] | junctional adhesion molecule 2 | 58494 | 0.9035049 | 137 | 1 | 0 | + | - | - | - | + | - | - | - | - | - | - | - | - | - | - | cell-cell adhesion
KCNS3 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | 3790 | -0.902696 | 604 | 1 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | transport, ion transport, potassium ion transport | potassium channel regulator activity, protein binding, potassium ion binding, ion channel activity, potassium channel activity, voltage-gated potassium channel activity, delayed rectifier potassium channel activity, voltage-gated ion channel activity
ACO2 | aconitase 2, mitochondrial | 50 | -0.9026474 | 812 | 0 | 0 | + | - | - | + | - | - | - | - | + | - | - | - | - | - | - | metabolic process, generation of precursor metabolites and energy, tricarboxylic acid cycle, citrate metabolic process | metal ion binding, iron ion binding, iron-sulfur cluster binding, 4 iron, 4 sulfur cluster binding, lyase activity, aconitate hydratase activity
FABP7 | fatty acid binding protein 7, brain | 2173 | -0.9024471 | 1335 | 0 | 0 | + | - | + | - | - | - | - | - | - | + | - | - | - | - | - | negative regulation of cell proliferation, prepulse inhibition, epithelial cell proliferation, cell proliferation in forebrain, neurogenesis, nervous system development, transport, startle response | binding, transporter activity, lipid binding, fatty acid binding
LASP1 | LIM and SH3 protein 1 | 3927 | 0.901861 | 322 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | cortical cytoskeleton organization, transport, ion transport | protein binding, metal ion binding, zinc ion binding, SH3-SH2 adaptor activity, [NAME], actin filament binding, ion transmembrane transporter activity
CABC1 | chaperone, ABC1 activity of bc1 complex homolog (S. pombe) | 56997 | -0.9012158 | 188 | 0 | 0 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | - | cell death | nucleotide binding, ATP binding, transferase activity, kinase activity
MRPS15 | mitochondrial ribosomal protein S15 | 64960 | -0.8997327 | 614 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | translation | structural constituent of ribosome
SHC1 | SHC ([NAME] homology 2 domain containing) transforming protein 1 | 6464 | 0.8992045 | 223 | 1 | 0 | + | - | + | - | + | - | - | - | + | + | - | + | - | - | - | angiogenesis, cell-cell adhesion, regulation of growth, positive regulation of cell proliferation, positive regulation of mitosis, positive regulation of smooth muscle cell proliferation, positive regulation of DNA replication, positive regulation of vasoconstriction, regulation of epidermal growth factor receptor activity, activation of MAPK activity <more data available...> | protein binding, phospholipid binding, transmembrane receptor [NAME] adaptor protein activity, protein complex binding, phosphoprotein binding, phosphotyrosine binding, insulin receptor binding, insulin-like growth factor receptor binding, epidermal growth factor receptor binding
EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 1915 | 0.8985183 | 287 | 2 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | translational elongation | protein binding, nucleotide binding, translation elongation factor activity, GTP binding, GTPase activity
SLCO2B1 | solute carrier organic anion transporter family, member 2B1 | 11309 | 0.897944 | 318 | 1 | 0 | + | - | + | - | - | - | - | - | - | + | - | - | - | - | + | transport, ion transport, organic anion transport | transporter activity, organic anion transmembrane transporter activity, sodium-independent organic anion transmembrane transporter activity
EIF4A1 | eukaryotic translation initiation factor 4A1 | 1973 | 0.891856 | 373 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | translation | protein binding, nucleic acid binding, nucleotide binding, RNA binding, mRNA binding, RNA cap binding, translation initiation factor activity, ATP binding, hydrolase activity, helicase activity <more data available...>
USP25 | ubiquitin specific peptidase 25 | 29761 | -0.888464 | 277 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | modification-dependent protein catabolic process, ubiquitin-dependent protein catabolic process, protein modification process, proteolysis | hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, cysteine-type peptidase activity, ubiquitin-specific protease activity
ACTB | actin, beta | 60 | 0.8856498 | 199 | 3 | 1 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | cell motion, axonogenesis, sensory perception of sound | protein binding, nucleotide binding, ATP binding, nitric-oxide synthase binding, protein kinase binding, structural constituent of cytoskeleton
DCXR | dicarbonyl/L-xylulose reductase | 51181 | -0.8829195 | 577 | 0 | 0 | + | - | - | + | - | - | - | - | + | - | - | - | - | - | - | metabolic process, [NAME] process, D-xylose metabolic process, xylulose metabolic process, NADP metabolic process, oxidation reduction, carbohydrate metabolic process | binding, catalytic activity, protein binding, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors, L-xylulose reductase activity
DHCR24 | 24-dehydrocholesterol reductase | 1718 | -0.8811062 | 704 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | negative regulation of cell proliferation, anti-apoptosis, negative regulation of caspase activity, neuroprotection, [NAME] protein signal transduction, cell cycle arrest, apoptosis, membrane organization, [NAME] process, sterol biosynthetic process <more data available...> | catalytic activity, peptide antigen binding, FAD binding, enzyme binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor, delta24-sterol reductase activity
ANXA2P2 | annexin A2 pseudogene 2 | 304 | 0.8750207 | 130 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | angiogenesis, fibrinolysis, collagen fibril organization | calcium ion binding, calcium-dependent phospholipid binding, phosphatidylinositol-4,5-bisphosphate binding, cytoskeletal protein binding, phospholipase inhibitor activity
GAMT | guanidinoacetate N-methyltransferase | 2593 | -0.8736085 | 351 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of multicellular organism growth, S-adenosylhomocysteine metabolic process, S-adenosylmethionine metabolic process, creatine biosynthetic process, organ morphogenesis, muscle contraction, spermatogenesis | protein homodimerization activity, transferase activity, methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, guanidinoacetate N-methyltransferase activity
TXNDC5 | thioredoxin domain containing 5 (endoplasmic reticulum) | 81567 | 0.873596 | 147 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | anti-apoptosis, cell redox homeostasis | isomerase activity
ASB8 | ankyrin repeat and SOCS box-containing 8 | 140461 | -0.8636313 | 179 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | intracellular signaling cascade, modification-dependent protein catabolic process
DBN1 | drebrin 1 | 1627 | 0.8633031 | 250 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of neuronal synaptic plasticity, regulation of dendrite development, actin filament organization, cell differentiation, multicellular organismal development, nervous system development | profilin binding, actin binding
GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | 2819 | -0.861118 | 989 | 2 | 1 | + | - | + | - | - | - | - | - | + | + | - | - | - | - | + | metabolic process, gluconeogenesis, glycerol-3-phosphate catabolic process, glycerol-3-phosphate metabolic process, glycerolipid metabolic process, NADH metabolic process, NADH oxidation, oxidation reduction, carbohydrate metabolic process | binding, catalytic activity, coenzyme binding, NAD or NADH binding, protein homodimerization activity, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors, glycerol-3-phosphate dehydrogenase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, glycerol-3-phosphate dehydrogenase (NAD+) activity
SEPT8 | septin 8 | 23176 | 0.8591971 | 410 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | cell cycle | protein binding, nucleotide binding, GTP binding
TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 7035 | 0.8573849 | 426 | 4 | 0 | + | - | + | + | + | - | - | - | - | + | - | + | - | - | - | blood coagulation, blood coagulation, extrinsic pathway | peptidase inhibitor activity, endopeptidase inhibitor activity, serine-type endopeptidase inhibitor activity
STUB1 | STIP1 homology and U-box containing protein 1 | 10273 | -0.8571803 | 816 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein ubiquitination, regulation of glucocorticoid metabolic process, ubiquitin-dependent SMAD protein catabolic process, modification-dependent protein catabolic process, protein folding, protein ubiquitination, protein polyubiquitination, protein maturation | binding, [NAME] binding, protein binding, bridging, Hsp70 protein binding, Hsp90 protein binding, protein homodimerization activity, TPR domain binding, ligase activity, ubiquitin-protein ligase activity, ubiquitin-ubiquitin ligase activity
TMED3 | transmembrane emp24 protein transport domain containing 3 | 23423 | 0.8570312 | 259 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | transport, protein transport
PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 5305 | 0.8569219 | 295 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | phosphatidylinositol metabolic process, phosphorylation | nucleotide binding, ATP binding, transferase activity, kinase activity, phosphatidylinositol phosphate kinase activity, 1-phosphatidylinositol-4-phosphate 5-kinase activity, 1-phosphatidylinositol-5-phosphate 4-kinase activity
ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 477 | -0.8553344 | 243 | 0 | 0 | + | - | + | - | - | - | - | + | - | + | - | - | - | - | - | locomotion, metabolic process, negative regulation of heart contraction, negative regulation of striated muscle contraction, regulation of respiratory gaseous exchange by neurological process, regulation of muscle contraction, regulation of vasoconstriction, regulation of the force of heart contraction, regulation of smooth muscle contraction, regulation of striated muscle contraction <more data available...> | catalytic activity, protein binding, nucleotide binding, metal ion binding, potassium ion binding, sodium ion binding, magnesium ion binding, ATP binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances <more data available...>
MRC2 | mannose receptor, C type 2 | 9902 | 0.8376657 | 169 | 2 | 0 | + | - | - | - | - | + | - | - | - | - | - | + | - | - | - | endocytosis | binding, sugar binding, calcium ion binding, collagen binding, receptor activity
MYBPC2 | [NAME] binding protein C, fast type | 4606 | -0.8340567 | 893 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | + | - | cell adhesion, muscle contraction, striated muscle contraction | protein binding, actin binding, structural constituent of cytoskeleton, structural constituent of muscle
CFL1 | cofilin 1 (non-muscle) | 1072 | 0.832675 | 345 | 0 | 0 | + | - | + | + | - | - | - | - | - | + | - | + | - | - | - | neural fold formation, anti-apoptosis, positive regulation of actin filament depolymerization, Rho protein signal transduction, negative regulation of cell size, cell motion, actin filament organization, cytokinesis, neural crest cell migration, cell projection organization <more data available...> | protein binding, actin binding
ENSA | endosulfine alpha | 2029 | -0.8306046 | 620 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | regulation of insulin secretion, transport, response to nutrient, response to glucose stimulus | potassium channel regulator activity, ion channel inhibitor activity, potassium channel inhibitor activity, receptor binding
NDUFS7 | NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) | 374291 | -0.8305923 | 837 | 0 | 0 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | - | biological_process, mitochondrial respiratory chain complex I assembly, electron transport chain, mitochondrial electron transport, NADH to ubiquinone, transport, oxidation reduction | molecular_function, protein binding, quinone binding, metal ion binding, iron ion binding, iron-sulfur cluster binding, 4 iron, 4 sulfur cluster binding, oxidoreductase activity, oxidoreductase activity, acting on NADH or NADPH, NADH dehydrogenase activity <more data available...>
SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | 8801 | -0.8264255 | 474 | 0 | 0 | - | - | - | - | - | - | - | - | + | - | - | - | - | - | - | metabolic process, tricarboxylic acid cycle, succinyl-CoA metabolic process | catalytic activity, ATP binding, ligase activity, succinate-CoA ligase (GDP-forming) activity, succinate-semialdehyde dehydrogenase activity
MAN2A2 | mannosidase, alpha, class 2A, member 2 | 4122 | -0.8264064 | 640 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | metabolic process, mannose metabolic process, carbohydrate metabolic process | carbohydrate binding, metal ion binding, zinc ion binding, alpha-mannosidase activity, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
ENO3 | enolase 3 (beta, muscle) | 2027 | -0.8253944 | 580 | 0 | 0 | + | + | + | - | - | - | - | + | + | + | - | - | - | - | - | glycolysis, aging, skeletal muscle regeneration, response to drug | metal ion binding, magnesium ion binding, protein homodimerization activity, protein heterodimerization activity, lyase activity, phosphopyruvate hydratase activity
FYN | FYN oncogene related to SRC, FGR, YES | 2534 | 0.8253328 | 262 | 1 | 1 | + | - | + | + | + | - | - | - | - | + | - | - | - | - | - | T cell receptor signaling pathway, regulation of cell shape, cell surface receptor linked signal transduction, ionotropic glutamate receptor signaling pathway, protein kinase cascade, myelination, activated T cell proliferation, neuron migration, peptidyl-tyrosine phosphorylation, protein amino acid phosphorylation <more data available...> | protein binding, nucleotide binding, metal ion binding, manganese ion binding, ATP binding, glycoprotein binding, identical protein binding, tubulin binding, transferase activity, kinase activity <more data available...>
NDUFB11 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa | 54539 | -0.824858 | 601 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | electron transport chain, transport
SGSH | N-sulfoglucosamine sulfohydrolase | 6448 | 0.8247777 | 220 | 0 | 0 | + | - | + | + | - | - | - | - | - | + | - | - | - | - | - | metabolic process, proteoglycan metabolic process, glycosaminoglycan metabolic process, heparan sulfate proteoglycan metabolic process | protein binding, calcium ion binding, hydrolase activity, N-sulfoglucosamine sulfohydrolase activity, sulfuric ester hydrolase activity
CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast) | 10486 | -0.8189907 | 311 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | signal transduction, activation of adenylate cyclase activity, establishment or maintenance of cell polarity, cytoskeleton organization | binding, actin binding
DUSP26 | dual specificity phosphatase 26 (putative) | 78986 | -0.8175273 | 408 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | protein amino acid dephosphorylation, dephosphorylation | hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine-serine-threonine phosphatase activity
PRKCDBP | protein kinase C, delta binding protein | 112464 | 0.817284 | 215 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | negative regulation of cell cycle, regulation of cell growth, cell cycle | protein kinase C binding
CCNG1 | cyclin G1 | 900 | -0.8166573 | 1017 | 1 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of cyclin-dependent protein kinase activity, cell growth, cell cycle, cell division, mitosis
ANKRD23 | ankyrin repeat domain 23 | 200539 | -0.8137043 | 338 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | - | - | fatty acid metabolic process | molecular_function
[NAME] | tetraspanin 13 | 27075 | 0.8133109 | 306 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
WBP4 | WW domain binding protein 4 (formin binding protein 21) | 11193 | -0.8107992 | 297 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | mRNA processing, RNA splicing | protein binding, nucleic acid binding, metal ion binding, zinc ion binding
FAM55C | family with sequence similarity 55, member C | 91775 | -0.8069978 | 911 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -
GOT1 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 2805 | -0.8066311 | 785 | 0 | 1 | + | + | + | - | - | - | - | - | + | + | - | - | - | - | + | fatty acid homeostasis, glycerol biosynthetic process, amino acid metabolic process, aspartate biosynthetic process, aspartate catabolic process, glutamate catabolic process to 2-oxoglutarate, glutamate catabolic process to aspartate, aspartate metabolic process, dicarboxylic acid metabolic process, oxaloacetate metabolic process <more data available...> | catalytic activity, carboxylic acid binding, pyridoxal phosphate binding, transferase activity, phosphatidylserine decarboxylase activity, transferase activity, transferring nitrogenous groups, transaminase activity, L-aspartate:2-oxoglutarate aminotransferase activity
DCUN1D2 | DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae) | 55208 | -0.8025502 | 201 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | modification-dependent protein catabolic process
OLFML3 | olfactomedin-like 3 | 56944 | 0.8004894 | 232 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | multicellular organismal development
POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 5438 | -0.7989496 | 452 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | transcription initiation from RNA polymerase II promoter, regulation of transcription, transcription, RNA elongation from RNA polymerase II promoter, nuclear mRNA splicing, via spliceosome | transcription regulator activity, nucleic acid binding, metal ion binding, zinc ion binding, DNA binding, DNA-directed RNA polymerase activity
USP13 | ubiquitin specific peptidase 13 (isopeptidase T-3) | 8975 | -0.794769 | 653 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | modification-dependent protein catabolic process, ubiquitin-dependent protein catabolic process | metal ion binding, zinc ion binding, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, cysteine-type peptidase activity, cysteine-type endopeptidase activity, ubiquitin-specific protease activity
IPO7 | importin 7 | 10527 | -0.7941059 | 293 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | protein import into nucleus, docking, signal transduction, intracellular protein transport, protein import into nucleus, transport, protein transport, interspecies interaction between organisms | binding, transporter activity, protein binding, histone binding, [NAME] binding, small GTPase regulator activity, protein transporter activity
MITF | microphthalmia-associated transcription factor | 4286 | -0.794089 | 713 | 5 | 0 | + | - | - | - | - | - | - | - | - | - | + | - | - | - | - | biological_process, pigmentation, negative regulation of apoptosis, positive regulation of transcription, DNA-dependent, positive regulation of transcription from RNA polymerase II promoter, regulation of cell proliferation, regulation of apoptosis, regulation of osteoclast differentiation, regulation of transcription, regulation of transcription, DNA-dependent <more data available...> | molecular_function, transcription regulator activity, chromatin binding, DNA binding, sequence-specific DNA binding, transcription factor activity, RNA polymerase II transcription factor activity, enhancer binding, transcription activator activity
MXRA7 | matrix-remodelling associated 7 | 439921 | 0.7895102 | 358 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
OSBPL11 | [NAME]like 11 | 114885 | -0.789103 | 1053 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | steroid metabolic process, transport, lipid transport
MRPL14 | mitochondrial ribosomal protein L14 | 64928 | -0.7804945 | 995 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | translation | structural constituent of ribosome
GYG1 | glycogenin 1 | 2992 | -0.7802188 | 701 | 0 | 0 | - | - | - | - | - | - | - | - | + | - | - | - | - | - | - | glycogen biosynthetic process | protein binding, glucose binding, transferase activity, transferase activity, transferring glycosyl groups, glycogenin glucosyltransferase activity
CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | 10217 | 0.7784797 | 317 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process | molecular_function, hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity
TSPO | translocator protein (18kDa) | 706 | 0.7772055 | 354 | 0 | 0 | + | - | + | + | + | - | - | + | + | + | - | - | - | - | - | regulation of cholesterol transport, cell proliferation, apoptosis, protein targeting to mitochondrion, steroid metabolic process, heme biosynthetic process, ion transport, anion transport | [NAME], benzodiazepine receptor activity, receptor activity
SDCBP | syndecan binding protein (syntenin) | 6386 | 0.7760141 | 425 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | substrate-bound cell migration, cell extension, intracellular signaling cascade, [NAME] protein signal transduction, actin cytoskeleton organization, synaptic transmission, protein targeting to membrane | protein binding, cytoskeletal adaptor activity, protein N-terminus binding, neurexin binding, syndecan binding, protein heterodimerization activity, interleukin-5 receptor binding
TMEM110 | [NAME] 110 | 375346 | -0.775754 | 1080 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process | molecular_function
PHKB | phosphorylase kinase, beta | 5257 | -0.7746448 | 823 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | generation of precursor metabolites and energy, glycogen metabolic process, carbohydrate metabolic process | catalytic activity, [NAME], transferase activity, kinase activity, phosphorylase kinase activity
SNTA1 | syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) | 6640 | -0.77079 | 363 | 0 | 0 | + | - | - | - | - | - | + | + | - | - | - | - | - | - | - | neuromuscular junction development, muscle contraction | protein binding, calcium ion binding, [NAME], actin binding, PDZ domain binding
[NAME] | protein phosphatase, Mg2+/Mn2+ dependent, 1F | 9647 | 0.7702579 | 437 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | apoptosis, protein amino acid dephosphorylation | catalytic activity, metal ion binding, manganese ion binding, magnesium ion binding, hydrolase activity, phosphoprotein phosphatase activity, protein serine-threonine phosphatase activity
CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 1051 | -0.7700915 | 747 | 8 | 6 | + | - | + | + | + | + | + | - | + | + | - | - | - | - | + | anti-apoptosis, induction of apoptosis, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of interleukin-6 biosynthetic process, regulation of transcription, DNA-dependent, neuron differentiation, fat cell differentiation, transcription, [NAME] development <more data available...> | protein binding, DNA binding, sequence-specific DNA binding, transcription factor activity, RNA polymerase II transcription factor activity, enhancer binding, protein dimerization activity, protein homodimerization activity, protein heterodimerization activity, transcription activator activity
PFKM | phosphofructokinase, muscle | 5213 | -0.7688932 | 477 | 0 | 0 | + | - | - | + | - | - | - | - | + | - | - | - | - | - | - | protein oligomerization, protein homotetramerization, positive regulation of insulin secretion, muscle maintenance, cellular glucose homeostasis, glucose homeostasis, glycolysis, fructose 1,6-bisphosphate metabolic process, fructose 6-phosphate metabolic process, glycogen metabolic process | catalytic activity, nucleotide binding, sugar binding, fructose-6-phosphate binding, metal ion binding, magnesium ion binding, AMP binding, ATP binding, protein C-terminus binding, identical protein binding <more data available...>
SGCA | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) | 6442 | -0.7607582 | 1188 | 0 | 2 | + | + | - | - | - | - | - | + | - | - | - | - | - | - | - | biological_process, membrane organization, muscle organ development, muscle contraction | molecular_function, protein binding, calcium ion binding
COX6A2 | cytochrome c oxidase subunit VIa polypeptide 2 | 1339 | -0.760675 | 586 | 0 | 0 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | - | generation of precursor metabolites and energy | cytochrome-c oxidase activity
ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | 487 | -0.7604934 | 970 | 0 | 1 | + | - | - | - | - | - | - | + | - | - | - | - | - | - | - | metabolic process, positive regulation of fast-twitch skeletal muscle fiber contraction, regulation of muscle contraction, regulation of striated muscle contraction, ATP biosynthetic process, transport, ion transport, cation transport, calcium ion transport | catalytic activity, protein binding, nucleotide binding, metal ion binding, calcium ion binding, magnesium ion binding, ATP binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism <more data available...>
PARVB | parvin, beta | 29780 | -0.7603214 | 609 | 0 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | - | - | - | cell adhesion | protein binding, actin binding
HPN | hepsin | 3249 | -0.7579112 | 679 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | + | cell growth, proteolysis | catalytic activity, hydrolase activity, peptidase activity, serine-type peptidase activity, serine-type endopeptidase activity, scavenger receptor activity
PTTG1IP | pituitary tumor-transforming 1 interacting protein | 754 | 0.7545177 | 342 | 1 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | protein import into nucleus | molecular_function
SAMM50 | sorting and assembly machinery component 50 homolog (S. cerevisiae) | 25813 | -0.7518265 | 525 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | biological_process, mitochondrial outer membrane translocase complex assembly | molecular_function
PPIA | peptidylprolyl isomerase A (cyclophilin A) | 5478 | 0.7517511 | 315 | 0 | 0 | + | - | + | + | + | - | - | - | - | + | - | - | - | - | - | regulation of viral genome replication, protein folding, provirus integration, interspecies interaction between organisms, initiation of viral infection | virion binding, peptide binding, unfolded protein binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity
EGLN1 | egl nine homolog 1 (C. elegans) | 54583 | -0.7498418 | 428 | 2 | 0 | + | - | - | - | - | - | - | + | - | - | - | - | + | - | - | negative regulation of transcription factor activity, oxygen homeostasis, [NAME], heart development, oxidation reduction, protein metabolic process, response to hypoxia | protein binding, metal ion binding, zinc ion binding, iron ion binding, L-ascorbic acid binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, peptidyl-proline dioxygenase activity
VEZF1 | vascular endothelial zinc finger 1 | 7716 | -0.7489519 | 528 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | + | - | - | - | angiogenesis, regulation of transcription from RNA polymerase II promoter, endothelial cell development, transcription, cellular defense response | nucleic acid binding, metal ion binding, zinc ion binding, DNA binding, specific RNA polymerase II transcription factor activity
SIVA1 | SIVA1, apoptosis-inducing factor | 10572 | -0.7485027 | 787 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | positive regulation of apoptosis, induction of apoptosis, apoptosis, interspecies interaction between organisms | protein binding, metal ion binding, zinc ion binding, tumor necrosis factor receptor binding, CD27 receptor binding, viral receptor activity
PGAM1 | phosphoglycerate mutase 1 (brain) | 5223 | 0.74708 | 186 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | metabolic process, regulation of pentose-phosphate shunt, regulation of glycolysis, glycolysis, respiratory burst | catalytic activity, protein kinase binding, hydrolase activity, isomerase activity, 2,3-bisphospho-D-glycerate 2-phosphohydrolase activity, intramolecular transferase activity, phosphotransferases, phosphoglycerate mutase activity, bisphosphoglycerate mutase activity
SESN1 | sestrin 1 | 27244 | -0.7440621 | 709 | 1 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | negative regulation of cell proliferation, cell cycle arrest, response to DNA damage stimulus
UBE2G1 | ubiquitin-conjugating enzyme [NAME] (UBC7 homolog, yeast) | 7326 | -0.7364407 | 646 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of protein metabolic process, modification-dependent protein catabolic process, ubiquitin-dependent protein catabolic process, post-translational protein modification, protein ubiquitination | ligase activity, small conjugating protein ligase activity, ubiquitin-protein ligase activity
PHYH | phytanoyl-CoA 2-hydroxylase | 5264 | -0.7364302 | 590 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | response to stimulus, fatty acid alpha-oxidation, nervous system development, oxidation reduction, lipid metabolic process, visual perception, sensory perception of sound | electron carrier activity, catalytic activity, protein binding, metal ion binding, iron ion binding, L-ascorbic acid binding, oxidoreductase activity, phytanoyl-CoA dioxygenase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
C11orf67 | chromosome 11 open reading frame 67 | 28971 | -0.7332999 | 607 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -
FAF1 | Fas (TNFRSF6) associated factor 1 | 11124 | -0.7303874 | 448 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | positive regulation of protein complex assembly, regulation of cell adhesion, cytoplasmic sequestering of NF-kappaB, positive regulation of apoptosis, regulation of protein catabolic process, cell death, apoptosis, proteasomal ubiquitin-dependent protein catabolic process | protein binding, heat shock protein binding, protein domain specific binding, protein kinase binding, NF-kappaB binding
[NAME] | DDB1 and CUL4 associated factor 6 | 55827 | -0.7197289 | 252 | 0 | 0 | NA | NA | NA | NA | - | - | - | - | - | - | - | - | - | - | -
MID1IP1 | MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) | 58526 | -0.7158336 | 743 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | negative regulation of microtubule depolymerization | protein binding, protein C-terminus binding
ACACB | acetyl-CoA carboxylase beta | 32 | -0.7148234 | 1118 | 0 | 2 | + | - | - | - | - | - | - | - | + | + | - | - | - | - | - | metabolic process, regulation of fatty acid oxidation, fatty acid biosynthetic process, acetyl-CoA metabolic process, response to drug, response to organic cyclic substance | nucleotide binding, metal ion binding, manganese ion binding, ATP binding, biotin binding, ligase activity, acetyl-CoA carboxylase activity, biotin carboxylase activity
EPM2A | epilepsy, progressive myoclonus type 2A, [NAME] disease (laforin) | 7957 | -0.7145185 | 451 | 0 | 0 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | - | glycogen metabolic process, protein amino acid dephosphorylation, dephosphorylation, nervous system development, carbohydrate metabolic process, behavior | catalytic activity, protein binding, carbohydrate binding, hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity, protein serine-threonine phosphatase activity, protein tyrosine-serine-threonine phosphatase activity
CCDC21 | coiled-coil domain containing 21 | 64793 | -0.714093 | 946 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
PLCL1 | phospholipase C-like 1 | 5334 | -0.7140181 | 851 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | intracellular signaling cascade, lipid metabolic process | calcium ion binding, phosphoinositide phospholipase C activity, signal transducer activity
FHOD1 | formin homology 2 domain containing 1 | 29109 | -0.7134495 | 582 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | cellular component organization, actin cytoskeleton organization | protein binding, actin binding
SATB1 | SATB homeobox 1 | 6304 | -0.7131208 | 752 | 0 | 0 | + | - | + | - | - | - | - | - | - | + | - | - | - | - | - | negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, T cell activation, CD8-positive, alpha-beta T cell differentiation, CD4-positive, alpha beta T cell differentiation, activated T cell proliferation, establishment or maintenance of chromatin architecture, histone methylation, reflex | transcription regulator activity, DNA binding, sequence-specific DNA binding, transcription factor activity, double-stranded DNA binding, transcription repressor activity
PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | 5532 | -0.7086505 | 581 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | negative regulation of T cell mediated cytotoxicity, signal transduction, regulation of gene expression, muscle maintenance, T cell homeostasis, T cell differentiation, protein amino acid dephosphorylation, heart development, response to cytokine stimulus, response to amphetamine | protein binding, metal ion binding, calcium ion binding, zinc ion binding, iron ion binding, [NAME], protein heterodimerization activity, hydrolase activity, phosphoprotein phosphatase activity, protein serine-threonine phosphatase activity <more data available...>
MYH14 | [NAME], heavy chain 14, non-muscle | 79784 | -0.7042131 | 920 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, regulation of cell shape, actin filament-based movement, sensory perception of sound | molecular_function, nucleotide binding, ATP binding, [NAME], [NAME], actin filament binding, motor activity, actin-dependent ATPase activity, microfilament motor activity
ANXA3 | annexin [NAME] | 306 | -0.6994975 | 922 | 0 | 0 | + | - | + | + | - | - | + | - | - | + | - | - | - | - | - | signal transduction | calcium ion binding, calcium-dependent phospholipid binding, phospholipase inhibitor activity, phospholipase A2 inhibitor activity
TPP1 | tripeptidyl peptidase I | 1200 | 0.6962268 | 260 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | bone resorption, lysosome organization, peptide catabolic process, nervous system development, protein catabolic process, proteolysis, lipid metabolic process, neuromuscular process controlling balance | protein binding, peptide binding, hydrolase activity, peptidase activity, endopeptidase activity, serine-type peptidase activity, serine-type endopeptidase activity, tripeptidyl-peptidase activity
PDK2 | pyruvate dehydrogenase kinase, isozyme 2 | 5164 | -0.6919173 | 878 | 0 | 2 | + | - | - | - | - | - | - | - | + | + | - | - | - | - | - | signal transduction, [NAME] process, peptidyl-histidine phosphorylation, protein amino acid phosphorylation, carbohydrate metabolic process | protein binding, ATP binding, transferase activity, kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity, protein histidine kinase activity, two-component sensor activity
AKTIP | AKT interacting protein | 64400 | -0.6916484 | 960 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | positive regulation of protein amino acid phosphorylation, regulation of protein metabolic process, positive regulation of protein binding, apoptosis, modification-dependent protein catabolic process, post-translational protein modification | protein binding, small conjugating protein ligase activity
FLII | flightless I homolog (Drosophila) | 2314 | -0.6906866 | 763 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | regulation of transcription, DNA-dependent, actin filament severing, actin cytoskeleton organization, transcription, multicellular organismal development, muscle contraction | protein binding, actin binding
SOS2 | son of sevenless homolog 2 (Drosophila) | 6655 | -0.6853376 | 1185 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of small GTPase mediated signal transduction, regulation of Rho protein signal transduction, intracellular signaling cascade, small GTPase mediated signal transduction | protein binding, DNA binding, guanyl-nucleotide exchange factor activity, [NAME] guanyl-nucleotide exchange factor activity, Rho guanyl-nucleotide exchange factor activity
BCL7A | B-cell CLL/lymphoma 7A | 605 | -0.6836637 | 840 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, negative regulation of transcription | molecular_function
FAM50B | family with sequence similarity 50, member B | 26240 | -0.682857 | 299 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -
[NAME] | ribonuclease P/MRP 14kDa subunit | 11102 | -0.6803194 | 983 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | tRNA processing | RNA binding, identical protein binding, hydrolase activity, ribonuclease activity, ribonuclease P activity
NDUFB4 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa | 4710 | -0.6784723 | 531 | 0 | 0 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | - | electron transport chain, mitochondrial electron transport, NADH to ubiquinone, transport, response to oxidative stress | NADH dehydrogenase (ubiquinone) activity
CAPN3 | calpain 3, (p94) | 825 | -0.6745806 | 803 | 0 | 0 | + | + | - | - | - | - | - | + | - | - | - | - | - | - | - | myofibril assembly, sarcomere organization, muscle organ development, proteolysis, response to drug, response to calcium ion | protein binding, calcium ion binding, hydrolase activity, peptidase activity, cysteine-type peptidase activity, cysteine-type endopeptidase activity, calcium-dependent cysteine-type endopeptidase activity, signal transducer activity
FIGF | c-fos induced growth factor (vascular endothelial growth factor D) | 2277 | -0.6736075 | 991 | 1 | 0 | + | - | + | + | + | - | - | - | - | + | - | + | - | - | - | angiogenesis, positive regulation of angiogenesis, positive regulation of cell proliferation, vascular endothelial growth factor receptor signaling pathway, cell proliferation, cell differentiation, multicellular organismal development | protein binding, protein homodimerization activity, vascular endothelial growth factor receptor binding, growth factor activity, platelet-derived growth factor receptor binding, vascular endothelial growth factor receptor 2 binding, vascular endothelial growth factor receptor 3 binding
PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | 5774 | -0.6691778 | 694 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | negative regulation of membrane protein ectodomain proteolysis, protein amino acid dephosphorylation | cytoskeletal protein binding, hydrolase activity, phosphatase activity, protein tyrosine phosphatase activity
CDC42SE1 | CDC42 small effector 1 | 56882 | 0.6674954 | 394 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | negative regulation of JNK cascade, signal transduction, regulation of cell shape, small GTPase mediated signal transduction, phagocytosis | molecular_function, protein binding, GTPase inhibitor activity
PARP4 | poly (ADP-ribose) polymerase family, member 4 | 143 | 0.6665693 | 348 | 0 | 0 | + | - | + | - | - | - | - | - | - | + | - | - | - | - | - | telomere maintenance via telomerase, cell death, protein modification process, protein amino acid ADP-ribosylation, DNA repair, transport, response to drug, inflammatory response, response to DNA damage stimulus | protein binding, DNA binding, enzyme binding, transferase activity, transferring glycosyl groups, NAD+ ADP-ribosyltransferase activity
FXYD5 | FXYD domain containing ion transport regulator 5 | 53827 | 0.661157 | 307 | 1 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | microvillus assembly, negative regulation of calcium-dependent cell-cell adhesion, transport, ion transport | cadherin binding, actin binding, ion channel activity
MDH2 | malate dehydrogenase 2, NAD (mitochondrial) | 4191 | -0.6602175 | 530 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | metabolic process, cellular carbohydrate metabolic process, glycolysis, tricarboxylic acid cycle, NADH metabolic process, malate metabolic process, oxidation reduction, carbohydrate metabolic process | binding, catalytic activity, protein binding, protein self-association, oxidoreductase activity, malate dehydrogenase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, L-malate dehydrogenase activity, malate dehydrogenase (NADP+) activity
ZNF672 | zinc finger protein 672 | 79894 | -0.656697 | 910 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of transcription, DNA-dependent, transcription | nucleic acid binding, metal ion binding, zinc ion binding, DNA binding
KPNA3 | [NAME] alpha 3 (importin alpha 4) | 3839 | -0.6553343 | 1000 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | protein complex assembly, intracellular protein transport, protein import into nucleus, NLS-bearing substrate import into nucleus, transport, protein transport | binding, protein binding, nuclear localization sequence binding, protein transporter activity
RPA1 | replication protein A1, 70kDa | 6117 | -0.652552 | 880 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | positive regulation of cell proliferation, homeostasis of number of cells within a tissue, meiosis, chromosome organization, DNA replication, DNA-dependent DNA replication, nucleotide-excision repair, DNA damage removal, DNA repair, nucleotide-excision repair, DNA gap filling, DNA recombination <more data available...> | protein binding, nucleic acid binding, chromatin binding, metal ion binding, zinc ion binding, DNA binding, single-stranded DNA binding
C9orf16 | chromosome 9 open reading frame 16 | 79095 | 0.6487215 | 282 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process | molecular_function
WDR47 | WD repeat domain 47 | 22911 | -0.6474259 | 879 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
TMEM50A | [NAME] 50A | 23585 | 0.6427024 | 395 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
KIAA0564 | KIAA0564 | 23078 | -0.6398145 | 633 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - |  | nucleotide binding, ATP binding, nucleoside-triphosphatase activity, ATPase activity
POLDIP2 | polymerase (DNA-directed), delta interacting protein 2 | 26073 | -0.6395173 | 971 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |  | protein binding, bridging
C1orf43 | chromosome 1 open reading frame 43 | 25912 | -0.6393079 | 655 | 0 | 0 | NA | NA | NA | NA | - | - | - | - | - | - | - | - | - | - | -
VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | 23230 | -0.6350526 | 815 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, Golgi to endosome transport, nervous system development, transport, protein transport, protein localization, social behavior, locomotory behavior | molecular_function, binding, transporter activity, protein binding
HOXA10 | homeobox A10 | 3206 | -0.6280907 | 1217 | 0 | 0 | + | - | + | - | - | - | - | - | - | + | - | - | - | - | - | regulation of transcription, regulation of transcription, DNA-dependent, transcription, multicellular organismal development, embryonic limb morphogenesis, skeletal system development, anterior-posterior pattern formation, proximal-distal pattern formation, spermatogenesis | transcription regulator activity, protein binding, DNA binding, sequence-specific DNA binding, transcription factor activity
IDE | insulin-degrading enzyme | 3416 | -0.6264969 | 938 | 1 | 1 | + | - | + | + | - | + | - | - | + | + | - | - | - | - | - | protein heterooligomerization, protein homotetramerization, negative regulation of proteolysis, signal transduction, hormone catabolic process, peptide catabolic process, cellular protein catabolic process, proteolysis involved in cellular protein catabolic process, beta-amyloid metabolic process, sex differentiation <more data available...> | catalytic activity, peptide hormone binding, insulin binding, metal ion binding, zinc ion binding, beta-endorphin binding, ATP binding, protein homodimerization activity, hydrolase activity, peptidase activity <more data available...>
CLTCL1 | clathrin, heavy chain-like 1 | 8218 | -0.6215233 | 1008 | 0 | 1 | + | - | + | - | - | - | - | - | - | + | - | - | - | - | - | vesicle-mediated transport, receptor-mediated endocytosis, intracellular protein transport, anatomical structure morphogenesis | structural molecule activity, protein binding, signal transducer activity
CANX | calnexin | 821 | 0.6212855 | 430 | 1 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | protein secretion, protein folding | protein binding, sugar binding, calcium ion binding, unfolded protein binding
CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 79745 | -0.6194884 | 1204 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -
EIF1 | eukaryotic translation initiation factor 1 | 10209 | -0.6104875 | 380 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of translational initiation, translational initiation, translation, response to stress | translation initiation factor activity
PBX1 | pre-B-cell leukemia homeobox 1 | 5087 | -0.6029513 | 641 | 0 | 0 | + | - | + | - | - | - | - | - | - | + | - | + | - | - | - | biological_process, negative regulation of neuron differentiation, positive regulation of cell proliferation, positive regulation of transcription from RNA polymerase II promoter, regulation of cell proliferation, regulation of transcription, regulation of transcription, DNA-dependent, regulation of ossification, C21-steroid hormone biosynthetic process, cell differentiation <more data available...> | molecular_function, transcription regulator activity, protein binding, DNA binding, sequence-specific DNA binding, transcription factor activity, protein heterodimerization activity
SH3BGR | SH3 domain binding glutamic acid-rich protein | 6450 | -0.6028403 | 1140 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, protein complex assembly | molecular_function, SH3-SH2 adaptor activity, SH3 domain binding
CBX7 | chromobox homolog 7 | 23492 | -0.6012797 | 669 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of transcription, DNA-dependent, chromatin assembly or disassembly, chromatin modification, transcription | protein binding, chromatin binding
ADSL | adenylosuccinate lyase | 158 | -0.5866614 | 789 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | protein tetramerization, aerobic respiration, purine nucleotide metabolic process, AMP biosynthetic process, purine nucleotide biosynthetic process, purine ribonucleotide biosynthetic process, response to nutrient, response to hypoxia | catalytic activity, lyase activity, N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
PPP6C | protein phosphatase 6, catalytic subunit | 5537 | -0.5818602 | 1103 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | cell cycle, [NAME] transition of mitotic cell cycle, protein amino acid dephosphorylation | protein binding, metal ion binding, iron ion binding, manganese ion binding, hydrolase activity, phosphoprotein phosphatase activity, protein serine-threonine phosphatase activity
SYPL1 | synaptophysin-like 1 | 6856 | -0.5785557 | 1032 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | synaptic transmission, transport | transporter activity
C20orf111 | chromosome 20 open reading frame 111 | 51526 | -0.5700606 | 738 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | -
SLC25A4 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | 291 | -0.5681647 | 719 | 1 | 0 | + | + | + | + | - | - | - | - | + | + | - | - | + | + | - | glutamate uptake during transmission of nerve impulse, mitochondrial genome maintenance, generation of precursor metabolites and energy, transport, ADP transport, ATP transport, interspecies interaction between organisms | binding, transporter activity, protein binding, adenine transmembrane transporter activity, adenine nucleotide transmembrane transporter activity, ATP:ADP antiporter activity
HSF2 | heat shock transcription factor 2 | 3298 | -0.5640826 | 943 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of transcription, regulation of transcription, DNA-dependent, transcription, transcription from RNA polymerase II promoter, spermatogenesis, response to stress | DNA binding, sequence-specific DNA binding, transcription factor activity, protein homodimerization activity, transcription coactivator activity
NDUFS3 | NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) | 4722 | -0.563968 | 1114 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | biological_process, negative regulation of cell growth, induction of apoptosis, oxygen and reactive oxygen species metabolic process, electron transport chain, mitochondrial electron transport, NADH to ubiquinone, transport, oxidation reduction | molecular_function, electron carrier activity, protein binding, oxidoreductase activity, oxidoreductase activity, acting on NADH or NADPH, NADH dehydrogenase activity, NADH dehydrogenase (ubiquinone) activity
HSPA9 | heat shock 70kDa protein 9 (mortalin) | 3313 | -0.5627162 | 1011 | 0 | 0 | + | - | + | + | + | - | - | - | - | + | - | - | - | - | - | anti-apoptosis, protein export from nucleus, protein folding, response to stress | protein binding, nucleotide binding, ATP binding, unfolded protein binding
CYC1 | cytochrome c-1 | 1537 | -0.5566498 | 974 | 0 | 0 | + | - | - | - | - | - | - | - | + | - | - | - | - | - | - | electron transport chain, transport, response to glucagon stimulus | molecular_function, electron carrier activity, metal ion binding, iron ion binding, heme binding, electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 481 | -0.550798 | 1194 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | + | ATP biosynthetic process, transport, ion transport, metal ion transport, potassium ion transport, sodium ion transport, response to hypoxia | protein binding, potassium ion binding, sodium ion binding, sodium:potassium-exchanging ATPase activity
ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 6767 | -0.533246 | 1156 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | protein folding, chaperone cofactor-dependent protein refolding | binding, protein complex binding, identical protein binding, protein domain specific binding, protein binding, bridging, Hsp70 protein binding
PTCD3 | Pentatricopeptide repeat domain 3 | 55037 | -0.5232793 | 1033 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - |  | protein binding
OGFOD1 | 2-oxoglutarate and iron-dependent oxygenase domain containing 1 | 55239 | -0.5199186 | 800 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | oxidation reduction, protein metabolic process | metal ion binding, iron ion binding, L-ascorbic acid binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
MRPL48 | mitochondrial ribosomal protein L48 | 51642 | -0.4637066 | 749 | 0 | 0 | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | translation | structural constituent of ribosome
EIF4A2 | eukaryotic translation initiation factor 4A2 | 1974 | -0.4505456 | 1040 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | regulation of translational initiation, translation, interspecies interaction between organisms, response to protein stimulus | protein binding, nucleic acid binding, nucleotide binding, RNA binding, translation initiation factor activity, ATP binding, hydrolase activity, helicase activity, ATP-dependent helicase activity
MOSC2 | MOCO sulphurase C-terminal domain containing 2 | 54996 | -0.4148994 | 1210 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | oxidation reduction | catalytic activity, pyridoxal phosphate binding, molybdenum ion binding, oxidoreductase activity
KARS | lysyl-tRNA synthetase | 3735 | -0.4032712 | 1155 | 0 | 0 | + | - | - | + | - | - | - | - | - | - | - | - | - | - | - | tRNA aminoacylation for protein translation, lysyl-tRNA aminoacylation, translation, diadenosine tetraphosphate biosynthetic process | protein binding, nucleic acid binding, nucleotide binding, amino acid binding, tRNA binding, ATP binding, ligase activity, aminoacyl-tRNA ligase activity, lysine-tRNA ligase activity