Spreadsheet: b346700b-a16b-4858-b114-b569477bd4aa
Sheet: Sheet1

[NAME] | Database | Full size | Pathway genes in BET subnetwork | BET enrichment q-value | Pathway genes in Lung subnetwork | Lung enrichment q-value
Adaptive Immune System | Reactome | 508 |  |  | RNF4, UBE2D2, SRC, TMEM189-UBE2V1, UBE2E3, PJA1, LRRC41, UBE2V1, [NAME], CDC42, UBE2L6, TAP1, RAC1, UBA1, SHC1, UBE2D4, UBE2Z, STUB1 | 0.0495549653561
Androgen receptor signaling pathway | Wikipathways | 85 | SUMO1, PARK7, HDAC1, PTK2, STUB1, RB1, JUN, RNF4, CDC42, UBE2I, RAC1, PTEN, RELA, CREB1 | 0.00091005343818 | NCOR2, ROCK2, STUB1, SRC, JUN, [NAME], RNF4, CDC42, UBE2I, BAG1, RAC1, STAT3 | 0.00113309961058
AndrogenReceptor | NetPath | 148 | JUN, [NAME], RB1, UBE2I, CREB1, RNF4, GTF2H1, PTEN, HSPA4, [NAME], [NAME], PARK7, PTK2, PXN, PPP1CA | 0.0022579628428 | JUN, SF1, UBE2I, BAG1, RNF4, SRC, [NAME], NCOR2, PXN, PPP1CA, STAT3 | 0.0205782698162
Antigen processing: Ubiquitination & Proteasome degradation | Reactome | 176 |  |  | UBE2E3, RNF4, UBE2D2, UBE2L6, UBE2Z, PJA1, LRRC41, UBA1, UBE2D4, STUB1, UBE2V1, [NAME], TMEM189-UBE2V1 | 0.00113309961058
AP-1 transcription factor network | PID | 70 | JUN, COPS5, MYC, CREB1, PTEN, TRIP6 | 0.0471611916599
Apoptosis Modulation and Signaling | Wikipathways | 90 | BNIP3, BCL2L1, BAG3, PTPN13, BIK, JUN, TOLLIP, FAS | 0.0193935688617 | IRAK1, BCL2L1, TNFRSF1A, BAG3, JUN, TOLLIP, MYD88 | 0.0495549653561
B Cell Receptor Signaling Pathway | Wikipathways | 93 | CDC42, CREB1, RAC1, MYC, JUN, RELA, SHC1 | 0.0354155178637
basic mechanisms of sumoylation | PID | 6 | SUMO3, SUMO2, UBE2I, UBA2, [NAME], SAE1 | 0.000469843598367 | SUMO3, UBE2I | 0.06823758820010001
BCR | NetPath | 132 | [NAME], RB1, PTK2, SHC1, CREB1, RELA, RPS6, HNRNPK | 0.0272425269707
Caspase cascade in apoptosis | PID | 53 | TFAP2A, LMNA, PTK2, [NAME], SREBF1 | 0.0471611916599
CD40/CD40L signaling | PID | 35 | JUN, BCL2L1, RELA, MYC | 0.0192011790591
Cell death signalling via NRAGE, NRIF and NADE | Reactome | 66 |  |  | APH1A, MCF2L, AATF, MAGED1, PSENEN, RAC1 | 0.0267114114015
Class I MHC mediated antigen processing & presentation | Reactome | 218 |  |  | LRRC41, RNF4, UBE2E3, UBE2D2, UBE2L6, PJA1, UBA1, UBE2D4, UBE2Z, STUB1, TAP1, UBE2V1, [NAME], TMEM189-UBE2V1 | 0.0177349602003
Cytosolic tRNA aminoacylation | PID | 24 | DARS, RARS, AIMP1, IARS, EPRS, KARS, AIMP2 | 0.0425149640826
DCC mediated attractive signaling | Reactome | 16 | RAC1, PTK2, CDC42 | 0.0471611916599 | SRC, RAC1, CDC42 | 0.0619796831837
Destabilization of mRNA by [NAME] | Reactome | 16 | EXOSC8, EXOSC4, EXOSC7 | 0.0249435574096
DNA damage response (only ATM dependent) | Wikipathways | 91 | MYC, CDC42, RAC1, BIK, JUN, PTEN, [NAME], SHC1 | 0.0403050237178
EGFR1 | NetPath | 462 | PDLIM4, TRIP6, IQGAP1, FLNB, PXN, ACTB, TOLLIP, [NAME], TRIM29, [NAME], PTEN, ANXA2, ENO1, RELA, [NAME], CLTC, RPLP0, JUN, CDC42, CREB1, PRKAR1A, RAC1, ANXA1, PTK2, MYC, SHC1, VCL, STAMBP | 0.0275428388448
EPHA2 forward signaling | PID | 18 | SHC1, PTK2, EPHA2, RAC1 | 0.0272425269707
ErbB2/ErbB3 signaling events | PID | 42 |  |  | SHC1, SRC, CDC42, RAC1, JUN, STAT3 | 0.0267114114015
erythropoietin mediated neuroprotection through nf-kb | PID | 13 | JUN, RELA, COPS5, CREB1 | 0.0272425269707
Eukaryotic Translation Elongation | Reactome | 148 | RPS3A, RPL28, RPL10, [NAME], EEF1G, RPS8, RPL7A, [NAME], RPS14, [NAME], RPS4X, RPL6, RPS6, [NAME], RPL15, RPLP0 | 0.0471611916599 | RPL28, RPL10, EEF1G, RPS8, RPL7A, [NAME], EEF1D, RPS14, [NAME], RPL15, RPLP0 | 0.0425471218621
Fc-epsilon receptor I signaling in mast cells | PID | 64 | PTK2, JUN, RELA, PXN, SHC1, PTPN13 | 0.0143747581872
[NAME] | Reactome | 994 | GTF2H1, EXOSC7, KARS, TAF9, [NAME], SNRPB, ANP32A, RPL7A, RPS14, EXOSC4, RPS4X, [NAME], [NAME], RPL28, AIMP2, [NAME], IARS, TRAM1, RPS6, [NAME], RPL15, RPLP0, POLR2G, RPS3A, [NAME], HNRNPC, NCBP1, LSM1, SSRP1, RARS, AIMP1, HNRNPK, [NAME], SEC61G, EPRS, [NAME], RPL10, EEF1G, RPS8, HNRNPD, [NAME], [NAME], RPL6, LSM7 | 0.0249435574096
HIF-1-alpha transcription factor network | PID | 66 | JUN, ENO1, COPS5, CREB1, SLC2A1, [NAME], BHLHE40 | 0.0471611916599
[NAME] negative effector of fas and tnf | PID | 54 | FAS, RB1, LMNA, PTK2, RELA | 0.0411626902139
IL-1 JNK | INOH | 62 |  |  | IRAK1, JUN, PSMC4, MYD88, UBE2V1, TOLLIP, TMEM189-UBE2V1 | 0.0385921566339
IL1 | NetPath | 56 |  |  | JUN, MYD88, IRAK1, UBE2V1, TOLLIP, TMEM189-UBE2V1 | 0.0267114114015
IL1-mediated signaling events | PID | 38 |  |  | IRAK1, JUN, MYD88, UBE2V1, TOLLIP, TMEM189-UBE2V1 | 0.0205782698162
IL2 signaling events mediated by PI3K | PID | 39 | RPS6, RELA, BCL2L1, RAC1, SHC1, MYC | 0.0101338642778
IL6 | NetPath | 78 | JUN, [NAME], [NAME], [NAME], RAC1, SHC1 | 0.0471611916599
Integrated Breast Cancer Pathway | Wikipathways | 152 | RHEB, CDC42, CREB1, ANXA1, RAC1, MYC, JUN, PHB, HDAC1, PTEN, RB1 | 0.0185024670464
Integrin-linked kinase signaling | PID | 46 | JUN, ZYX, CDC42, PXN, RAC1, CREB1, IQGAP1, [NAME] | 0.00908625127589 | JUN, ZYX, CDC42, NCK2, PXN, RAC1 | 0.0541797523707
Interleukin-1 signaling | PID | 31 |  |  | IRAK1, TOLLIP, MYD88, UBE2V1, TMEM189-UBE2V1 | 0.0267114114015
Internalization of ErbB1 | PID | 39 | STAMBP, CDC42, PTK2, SHC1, UBE2D3 | 0.0557238375965 | UBE2D2, SRC, CDC42, SHC1, HGS | 0.0355734672359
Leptin signaling pathway | Wikipathways | 61 | BCL2L1, CDC42, RAC1, SHC1, RPS6, CREB1, RELA | 0.0244397228337
mechanism of gene regulation by peroxisome proliferators via ppara | PID | 52 | [NAME], RB1, RELA, PRKAR1A, MYC | 0.0471611916599
Metabolism of mRNA | Reactome | 230 | RPL36, RPL6, PABPC1, RPL28, RPL10, EXOSC7, [NAME], RPS8, RPL15, ANP32A, RPS3A, HNRNPD, [NAME], NCBP1, RPL7A, [NAME], RPS14, LSM1, EXOSC4, RPS4X, RPS6, LSM7, [NAME], [NAME], RPLP0 | 0.00337171329179 | RPL36, RPL28, RPL10, RPS8, RPL15, HNRNPD, RPL7A, [NAME], RPS14, UPF1, [NAME], [NAME], RPLP0 | 0.0650366619167
Metabolism of RNA | Reactome | 278 | RPL36, PABPC1, RPL28, RPL10, [NAME], ANP32A, EXOSC7, SNRPB, RPS3A, HNRNPD, NCBP1, RPL7A, [NAME], RPL15, RPS14, LSM1, EXOSC4, [NAME], RPS4X, RPS6, RPL6, LSM7, [NAME], RPS8, EXOSC8, RPLP0 | 0.0103993034935 | RPL36, RPL28, RPL10, HNRNPD, RPL7A, [NAME], RPL15, RPS14, UPF1, [NAME], [NAME], RPS8, RPLP0 | 0.074427755714
mRNA Decay by 3, to 5, Exoribonuclease | Reactome | 11 | EXOSC8, EXOSC4, EXOSC7 | 0.0249435574096
mRNA Decay by 3&#x27; to 5&#x27; Exoribonuclease | PID | 11 | EXOSC8, EXOSC4, EXOSC7 | 0.0249435574096
Nonsense Mediated Decay Enhanced by the Exon Junction Complex | Reactome | 159 | RPS3A, PABPC1, RPL28, RPL10, [NAME], RPS8, NCBP1, RPL7A, [NAME], RPS14, [NAME], RPS4X, RPL6, RPS6, [NAME], RPL15, RPLP0 | 0.0354155178637 | RPL28, RPL10, RPS8, RPL7A, [NAME], RPS14, UPF1, [NAME], [NAME], RPL15, RPLP0 | 0.0495549653561
Nonsense Mediated Decay Independent of the Exon Junction Complex | Reactome | 147 | RPS3A, PABPC1, RPL28, RPL10, [NAME], RPS8, NCBP1, RPL7A, [NAME], RPS14, [NAME], RPS4X, RPL6, RPS6, [NAME], RPL15, RPLP0 | 0.0272425269707 | RPL28, RPL10, RPS8, RPL7A, [NAME], RPS14, UPF1, [NAME], RPL15, RPLP0 | 0.0619796831837
Nonsense-Mediated Decay | Reactome | 159 | RPS3A, PABPC1, RPL28, RPL10, [NAME], RPS8, NCBP1, RPL7A, [NAME], RPS14, [NAME], RPS4X, RPL6, RPS6, [NAME], RPL15, RPLP0 | 0.0354155178637 | RPL28, RPL10, RPS8, RPL7A, [NAME], RPS14, UPF1, [NAME], [NAME], RPL15, RPLP0 | 0.0495549653561
p38 mapk signaling pathway | PID | 35 | [NAME], CREB1, RAC1, MYC, CDC42 | 0.0185024670464
p38 MAPK Signaling Pathway | Wikipathways | 34 | SHC1, MYC, CDC42, [NAME], CREB1, RAC1 | 0.0101338642778 | SHC1, CDC42, [NAME], RAC1 | 0.0613982025591
p75 NTR receptor-mediated signalling | Reactome | 88 |  |  | IRAK1, MCF2L, MAGED1, MYD88, RAC1, APH1A, AATF, PSENEN | 0.0205782698162
p75(NTR)-mediated signaling | PID | 71 |  |  | IRAK1, MYD88, RAC1, APH1A, SHC1, MAGED1, PSENEN | 0.0245924769958
[NAME] | Wikipathways | 75 | RAC1, PXN, PTK2, MYC, JUN, SHC1, RPS6, RELA | 0.0245165185549
pten dependent cell cycle arrest and apoptosis | PID | 15 | PTEN, PTK2, SHC1 | 0.0471611916599
RANKL-RANK Signaling Pathway | Wikipathways | 55 | PTK2, CDC42, JUN, RELA, RAC1 | 0.0283724328918
Regulation of gene expression in beta cells | PID | 153 | RPS3A, RPL10, RPL28, [NAME], RPS8, RPL7A, [NAME], RPS14, [NAME], RPS4X, RPS6, RPL6, [NAME], RPL15, RPLP0 | 0.0483680950279
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements | Reactome | 40 | HSPB1, PABPC1, ANP32A, EXOSC4, EXOSC7, [NAME], HNRNPD | 0.0103820574394
regulation of transcriptional activity by pml | PID | 10 | UBE2I, [NAME], RB1 | 0.0249435574096
repression of pain sensation by the transcriptional regulator dream | PID | 15 | JUN, PRKAR1A, CREB1 | 0.0249435574096
Signaling events mediated by focal adhesion kinase | PID | 62 |  |  | RAC1, JUN, ROCK2, SRC, NCK2, PXN, VCL | 0.0267114114015
Signaling events mediated by HDAC Class I | PID | 57 | UBE2I, HDAC1, [NAME], RELA, CHD4, HDAC3 | 0.0435576323034
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | PID | 84 | JUN, RAC1, SHC1, KPNB1, CDC42, PTK2, PXN | 0.0666728604234 | JUN, SRC, RAC1, SHC1, HGS, CDC42, NCK2, PXN | 0.0267114114015
Signaling events regulated by Ret tyrosine kinase | PID | 40 | JUN, PTK2, PXN, RAC1, SHC1, CREB1 | 0.0249435574096 | JUN, SRC, PXN, RAC1, SHC1 | 0.0512249813465
Sumoylation by RanBP2 regulates transcriptional repression | PID | 15 | UBE2I, [NAME], HDAC1 | 0.0471611916599
TCR Signaling Pathway | Wikipathways | 91 | CDC42, CREB1, RELA, JUN, SHC1, FAS | 0.0471611916599
TGF beta Signaling Pathway | Wikipathways | 117 | UBE2I, PTK2, CDC42, COPS5, RAC1, [NAME], MYC, JUN, HDAC1, SHC1 | 0.0272425269707 | UBE2I, CDC42, SRC, NEDD9, HGS, PJA1, RAC1, JUN, SHC1 | 0.0490173233328
TLR ECSIT MEKK1 JNK | INOH | 26 |  |  | IRAK1, JUN, MYD88, TOLLIP | 0.0495549653561
TLR JNK | INOH | 62 |  |  | IRAK1, JUN, MYD88, UBE2V1, PSMC4, TOLLIP, TMEM189-UBE2V1 | 0.0385921566339
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | Reactome | 13 |  |  | IRAK1, UBE2V1, MYD88, TMEM189-UBE2V1 | 0.0267114114015
TSH signaling pathway | Wikipathways | 65 | RB1, MYC, JUN, APEX1, RPS6, CREB1 | 0.0471611916599