Spreadsheet: ab6816e2-9c77-401d-9cca-52604a6c4f66
Sheet: Sheet1

Expression profiles of signalling pathways components encoding genes during adult heart organogenesis | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7
Symbol | [NAME] | Signal | SAM 5% | Profile | FC | Cluster | Function comments
Dpp pathway
dpp | decapentaplegic | - | No |  |  |  | ligand - TGFß homolog
tkv | thickveins | - | No |  |  |  | Dpp receptor
sax | saxophone | +/- | No |  |  |  | Dpp receptor
put | punt | + | No |  |  |  | Dpp receptor
Mad | Mothers against dpp | +/- | No |  |  |  | Smad1 homolog
Med | Medea | + | No |  |  |  | Smad4 homolog
Smox | [NAME] on X | +/- | No |  |  |  | Smad2-3 homolog
Dad | Daughters against dpp | + | No |  |  |  | [NAME] family - Dpp signal inhibitor
brk | brinker | + | Yes | up­ | 2.383225027225963 | 10 | transcription factor that negatively regulates Dpp target genes
EGF receptor signaling
argos | argos | - | No |  |  |  | [NAME]
grk | gurken | + | No |  |  |  | [NAME]
spi | spitz | + | Yes | up­ | 2.479775845744 | 6 | [NAME]
vn | [NAME] | + | No |  |  |  | [NAME] (weak)
[NAME] | Epidermal growth factor receptor | - | No |  |  |  | EGF receptor
pnt | pointed | +/- | No |  |  |  | a target of EGF signaling
ed | echinoid | + | Yes | up­ | 3.85327147528 | 8 | antagonist of EGF signaling
rho | rhomboid | + | Yes | up­ | 1.64154257842 |  | required for the production or processing of Spitz
ru | roughoid | - | No |  |  |  | acts with Rhomboid
S | Star | - | No |  |  |  | acts with Rhomboid
FGF receptor signaling
pyr | pyramus | + | Yes | up­ | 2.249155145752656 | 6 | ligand for Heartless
ths | thisbe | + | Yes | up­ | 3.5491827561512 | 7 | ligand for Heartless - closely linked to [NAME]
bnl | branchless | + | Yes | up­ | 4.9589797979 | 9 | ligand for Breathless
htl | heartless | + | No |  |  |  | FGF receptor - mesodermal development
btl | breathless | - | No |  |  |  | FGF receptor - tracheal development
sty | sprouty | + | Yes | up­ | 2.126732614167541 | 9 | antagonist of FGF signaling
stumps | stumps | + | Yes | down¯ | 3.495442997 | 13 | signal transduction protein
Cbl | Cbl | + | No |  |  |  | physically interacts with Sprouty
Hedgehog pathway
hh | hedgehog | - | No |  |  |  | signaling molecule - morphogen
smo | smoothened | +/- | No |  |  |  | a receptor for Hedgehog
ptc | patched | + | No |  |  |  | a receptor for Hedgehog
fu | fused | +/- | No |  |  |  | cytoplasmic component of Hedgehog signaling
Su(fu) | Suppressor of fused | + | Yes | up­ | 1.6859147543375 |  | antagonist of Hedgehog signaling
shf | shifted | + | Yes | up­ | 7.9279541823449 | 6 | required for Hh stability and for lipid-modified Hh diffusion
disp | dispatched | - | No |  |  |  | patched family protein regulating Hedgehog release
ci | cubitus interruptus | + | No |  |  |  | mediates Hedgehog signaling
cos | costa | + | Yes | up­ | 1.615869418676708 |  | a cytoplasmic anchor for ci
nej | nejire | +/- | No |  |  |  | coactivator of ci
Insulin receptor signaling & TOR pathways
chico | chico | +/- | No |  |  |  | insulin receptor substrate family
InR | Insulin-like receptor | - | No |  |  |  | insukin receptor
Akt1 | Akt1 | + | No |  |  |  | protein kinase B (PKB)
Pi3K92E | Pi3K92E | + | No |  |  |  | also known as Dp110
melt | melted | - | No |  |  |  | modulator of the insulin/PI3K signaling pathway
Pten | Pten | +/- | No |  |  |  | lipid and protein phosphatase acting in insulin pathway
Tor | Target of rapamycin | + | No |  |  |  | pivotal member of the TOR pathway
RpS6 | Ribosomal protein S6 | + | No |  |  |  | RPS6 phosphorylation is correlated with regulation of mRNA translation
S6k | RPS6-p70-protein kinase | + | No |  |  |  | targets Ribosomal protein S6 - target of TOR pathway
[NAME] | [NAME] | - | No |  |  |  | [NAME] binding
scyl | scylla | + | No |  |  |  | downstream of Akt1 and upstream of Tsc to regulate growth
chrb | charybde | + | Yes | down¯ | 2.579183889982837 | 13 | downstream of Akt1 and upstream of Tsc to regulate growth
foxo | forkhead box, sub-group O | +/- | Yes | down¯ | 1.4967552532644 |  | transcription factor - a target of the insulin pathway
gig | gigas | + | No |  |  |  | a modifier of the insulin pathway
Thor | Thor | + | Yes | down¯ | 2.299661299637 | 4 | [NAME] cap binding protein
JAK/STAT signaling pathway
os | outstretched | +/- | No |  |  |  | a cytokine - also known as unpaired
dome | domeless | + | No |  |  |  | a cytokine receptor
hop | hopscotch | +/- | No |  |  |  | Drosophila's Janus kinase (D-JAK)
Stat92E | Stat92E | + | Yes | down¯ | 1.9879938219158 | 3 | Signal-transducer and activator of transcription protein at 92E (D-STAT)
Stam | Stam | + | Yes | down¯ | 2.4238288591941 | 3 | Signal transducing adaptor molecule
JNK pathway
egr | [NAME] | + | Yes | down¯ | 4.627552813177 | 4 | a TNF superfamily ligand
bsk | basket | + | No |  |  |  | Jun N-terminal kinase (JNK)
hep | hemipterous | +/- | No |  |  |  | a kinase (MapKK/JunKK)
Jra | Jun-related antigen | + | No |  |  |  | D-Jun - transcription factor - basic leucine zipper
kay | kayak | - | No |  |  |  | D-Fos - transcription factor - basic leucine zipper
chm | chameau | + | No |  |  |  | recruited by DJun and DFos
puc | puckered | +/- | No |  |  |  | JNK specific phosphatase
msn | misshapen | + | No |  |  |  | SPS1 family kinase - functions upstream of Basket
Tak1 | TGF-b activated kinase 1 | - | No |  |  |  | induces JNK signaling activity
wgn | wengen | + | Yes | up­ | 2.9853895564416 | 9 | required for Eiger Signaling
Traf1 | TNF-receptor-associated factor 1 | + | Yes | down¯ | 1.491738722196655 |  | Traf domain protein - regulator of JNK pathway
Notch pathway
Dl | Delta | + | Yes | up­ | 2.2234338156479 | 9 | Notch ligand
Ser | Serrate | - | No |  |  |  | Notch ligand
N | Notch | + | No |  |  |  | transmembrane receptor
O-fut1 | O-fucosyltransferase 1 | +/- | Yes | down¯ | 1.5542977879373 |  | essential for the physical interaction of Notch with its ligand Delta
numb | numb | + | Yes | down¯ | 2.1 | 3 | an antagonist of the Notch signaling pathway
H | Hairless | + | No |  |  |  | a major antagonist of the Notch signaling pathway
Su(H) | Suppressor of Hairless | + | Yes | down¯ | 1.982979744242 | 4 | transcription factor - physically interacts with Notch
mam | mastermind | + | Yes | up­ | 3.266458135741328 | 8 | a transcriptional activator for Notch signaling with Su(H)
neur | neuralized | + | Yes | up­ | 2.723351689592 | 8 | modulates the Notch signal at the receptor/ligand level
dx | [NAME] | +/- | No |  |  |  | binds to the cytoplasmic domain of Notch that frees Su(H)
Su(dx) | Suppressor of deltex | + | Yes | up­ | 1.69285353232898 |  | regulator of the Notch pathway
fng | fringe | +/- | No |  |  |  | antagonist by targeting extracellular domain of Notch
[NAME] | Presenilin | + | Yes | down¯ | 2.423153464528 | 4 | [NAME] involved in proteolysis of Notch
nct | nicastrin | + | Yes | down¯ | 2.2235569933863 | 3 | component of a proteolytic complex, along with Presenilin
fred | friend of echinoid | - | No |  |  |  | interacts with the Notch pathway
E(spl) | Enhancer of split | ND |  |  |  |  | transcription factor - target of Notch pathway
Toll pathway
spz | spatzle | - | No |  |  |  | Toll ligand - secreted
Tl | Toll | + | Yes | up­ | 2.1963587664276 | 8 | transmembrane receptor
Myd88 | Myd88 | + | Yes | down¯ | 1.975788165982 | 3 | an adapter protein in the signal transduction pathway
tub | tube | +/- | No |  |  |  | cofactor with pelle to activate [NAME]
pll | pelle | + | No |  |  |  | S/T kinase - signal transduction protein
cact | cactus | + | Yes | up­ | 2.58163776665 | 11 | IkappaB homolog - regulates the nuclear transport of [NAME]
Dif | Dorsal-related immunity factor | + | Yes | up­ | 6.4975262174792 | 10 | transcription factor - NFkappaB/rel homolog
dl | dorsal | + | Yes | up­ | 2.52136441764 | 9 | transcription factor - NFkappaB/rel homolog
Torso pathway
trk | trunk | + | Yes | down¯ | 2.366715513337 | 4 | Torso ligand - secreted
tor | torso | - | No |  |  |  | [NAME] receptor [NAME]
cic | capicua | + | Yes | down¯ | 2.371274939549539 | 3 | transcription factor
tsl | torso-like | +/- | No |  |  |  | localized determinant for activation of Torso
PDGF-VEGF pathway
Pvf1 | PDGF- and VEGF-related factor 1 | + | No |  |  |  | ligand for [NAME]
Pvf2 | PDGF- and VEGF-related factor 2 | + | Yes | up­ | 3.167474134231 | 6 | ligand for [NAME]
Pvf3 | PDGF- and VEGF-related factor 3 | - | No |  |  |  | ligand for [NAME]
[NAME] | PDGF- and VEGF-receptor related | + | Yes | up­ | 1.955361615979302 | 9 | Ig C-2 type domain receptor [NAME]
Wnt pathway
wg | wingless | + | No |  |  |  | [NAME] family
Wnt2 | Wnt oncogene analog 2 | - | No |  |  |  | ligand - Wnt homolog - male reproductive tract/testis morphogenesis
Wnt4 | Wnt oncogene analog 4 | + | Yes | up­ | 5.968358354843 | 7 | ligand - TGF-B homolog - mesodermal - a Wingless antagonist
fz | frizzled | + | Yes | up­ | 2.587625427593405 | 8 | [NAME] receptor for Wingless
fz2 | frizzled 2 | + | No |  |  |  | [NAME] receptor for Wingless
fz3 | frizzled 3 | - | No |  |  |  | [NAME] Wingless signal
dally | division abnormally delayed | + | Yes | up­ | 3.2965461142746 | 7 | membrane bound glypican related proteoglycan
dlp | dally-like | + | Yes | up­ | 2.513875286173798 | 11 | membrane bound glypican related proteoglycan
dsh | dishevelled | + | No |  |  |  | a major component in the Wingless pathway
Axn | Axin | - | No |  |  |  | binds to beta-catenin to inhibit Wnt signaling
arm | armadillo | + | No |  |  |  | beta catenin homolog -signal transduction protein
pan | pangolin | - | No |  |  |  | dTCF - transcription factor - acts to transduce the Wingless signal
pygo | pygopus | +/- | No |  |  |  | acts downstream of or at the level of Pangolin in Wingless signaling
lgs | legless | + | No |  |  |  | permits ß-catenin to activate Wnt target genes
nkd | naked cuticle | + | Yes | down¯ | 1.922279755682271 | 3 | inducible antagonist for the Wnt signal Wingless
[NAME] | lines | ND |  |  |  |  | acting downstream or in parallel to Armadillo