Spreadsheet: 0752d9e4-7d9e-49fe-949b-89a614fc1af1
Sheet: Figure 2

 |  |  |  | Only Uses Cytoplasmic Metabolites |  |  |  | All Non-Transport Metabolites
Type of Limitation | Nutrient Name | Normalized Shadow Price (Normalized to maximum shadow price for condition) | Shadow Price | Growth Limitation | Metabolite Index |  |  | Type of Limitation | Nutrient Name | Normalized Shadow Price (Normalized to maximum shadow price for condition) | Shadow Price | Growth Limitation | Metabolite Index
Glucose | Pyruvate | -0.172297297297297 | -0.0368 | 0.844598819 | 1023 |  |  | Glucose | Pyruvate |  | -0.0368 | 0.844598819 | 1023
 | Dihydroxyacetone-Phosphate | -0.257 | -0.0549 | 0.69258 | 436 |  |  |  | Pyruvate |  | -0.0383 | 0.844598819 | 1025
 | Threonine | -0.344594594594594 | -0.0736 | 0.700085591 | 1110 |  |  |  | Pyruvate |  | -0.0267 | 0.844598819 | 1026
 | Arginine | -0.5641 | -0.1205 | 1.16 | 291 |  |  |  | Dihydroxyacetone-Phosphate |  | -0.0549 | 0.69258 | 436
 | N-acetyl-glucosamine-1-phosphate | -0.6825 | -0.1458 | 0.966 | 219 |  |  |  | Dihydroxyacetone-Phosphate |  | -0.0549 | 0.69258 | 437
 | Glutamate | -0.347972972972972 | -0.0743 | -0.470376237 | 578 |  |  |  | Threonine |  | -0.0736 | 0.700085591 | 1110
 | NAD+ | 0 | 0 | -0.567254951 | 841 |  |  |  | Threonine |  | -0.0751 | 0.700085591 | 1112
Ammonium | Glutamine | -0.4 | -0.3576 | 1.793905999 | 569 |  |  |  | Arginine |  | -0.1205 | 1.16 | 291
 | Arginine | -0.8 | -0.7152 | 1.867461707 | 291 |  |  |  | Arginine |  | -0.122 | 1.16 | 293
 | Serine | -0.2 | -0.1788 | 1.403000569 | 1052 |  |  |  | N-acetyl-glucosamine-1-phosphate |  | -0.1458 | 0.966 | 219
 | Ornithine | -0.4 | -0.3576 | 1.367755255 | 906 |  |  |  | Glutamate |  | -0.0743 | -0.470376237 | 578
 | Leucine/isoleucine | -0.2 | -0.1788 | 1.174856413 | 710 |  |  |  | Glutamate |  | -0.0743 | -0.470376237 | 580
 | Tryptophan | -0.4 | -0.3576 | 1.119659393 | 1166 |  |  |  | Glutamate |  | -0.0743 | -0.470376237 | 583
 | Histidine | -0.6 | -0.5364 | 1.784827952 | 673 |  |  |  | NAD+ |  | 0 | -0.567254951 | 844
 | Lysine | -0.4 | -0.3576 | 1.008454651568789 | 764 |  |  |  | NAD+ |  | 0 | -0.567254951 | 840
 | Alanine | -0.2 | -0.1788 | 0.9193850334864546 | 257 |  |  |  | NAD+ |  | 0 | -0.567254951 | 841
 | Phenylpyruvate | 0 | 0 | -0.818415757 | 957 |  |  | Ammonium | Glutamine |  | -0.3576 | 1.793905999 | 569
 | Trehalose | 0 | 0 | -1.397192183 | 1128 |  |  |  | Arginine |  | -0.7152 | 1.867461707 | 291
 | Sucrose | 0 | 0 | -1.397192183 | 1082 |  |  |  | Arginine |  | -0.7152 | 1.867461707 | 293
Phosphate | ATP | -1 | -15.1745 | 0.6997623 | 314 |  |  |  | Serine |  | -0.1788 | 1.403000569 | 1052
 | Ribose-phosphate | -0.333333333333333 | -5.0582 | 2.035591456 | 1031 |  |  |  | Serine |  | -0.1788 | 1.403000569 | 1054
 | D-sedoheptulose-7-phosphate | -0.333333333333333 | -5.0582 | 1.470061686 | 1043 |  |  |  | Ornithine |  | -0.3576 | 1.367755255 | 906
 | 6-phospho-d-gluconate | -0.333333333333333 | -5.0582 | 2.325754767 | 171 |  |  |  | Ornithine |  | -0.3576 | 1.367755255 | 908
 | NAD+ | 0 | 0 | 0.38 | 841 |  |  |  | Leucine/isoleucine |  | -0.1788 | 1.174856413 | 710
 | Fructose-1,6-bisphosphate | -0.666666666666666 | -10.1163 | 2.590906528 | 510 |  |  |  | Leucine/isoleucine |  | -0.1788 | 1.174856413 | 754
 | UDP-D-glucose | -0.666666666666666 | -10.1163 | 0.77245413 | 1191 |  |  |  | Leucine/isoleucine |  | -0.1788 | 1.174856413 | 756
 | N-acetyl-glucosamine-1-phosphate | -0.333 | -5.0582 | 1.54 | 219 |  |  |  | Leucine/isoleucine |  | -0.1788 | 1.174856413 | 712
 | CTP | -1 | -15.1745 | 0.718712663 | 388 |  |  |  | Tryptophan |  | -0.3576 | 1.119659393 | 1166
 | UTP | -1 | -15.1745 | 1.126480962 | 1205 |  |  |  | Tryptophan |  | -0.3576 | 1.119659393 | 1168
 | Choline | 0 | 0 | -1.895886942 | 354 |  |  |  | Histidine |  | -0.5364 | 1.784827952 | 673
 | Deoxyguanosine | 0 | 0 | -1.318965371 | 432 |  |  |  | Histidine |  | -0.5364 | 1.784827952 | 675
 | Cytosine | 0 | 0 | -1.849070073 | 386 |  |  |  | Lysine |  | -0.3576 | 1.008454651568789 | 764
 | [NAME] | 0 | 0 | -2.111004263 | 606 |  |  |  | Lysine |  | -0.3576 | 1.008454651568789 | 766
 | Adenosine | 0 | 0 | -1.386737341 | 235 |  |  |  | Alanine |  | -0.1788 | 0.9193850334864546 | 257
 | Cytidine | -2.34123831432887e-16 | 0 | -1.835201644 | 395 |  |  |  | Alanine |  | -0.1788 | 0.9193850334864546 | 259
 | Inosine | 0 | 0 | -2.747895523 | 727 |  |  |  | Phenylpyruvate |  | 0 | -0.818415757 | 957
Leucine | Nicotinate | 0 | 0 | 1.216210256 | 837 |  |  |  | Trehalose |  | 0 | -1.397192183 | 1128
 | Pyruvate | 0 | 0 | -0.486558139 | 1023 |  |  |  | Trehalose |  | 0 | -1.397192183 | 1130
 | Phenylpyruvate | 0 | 0 | -1.408510173 | 957 |  |  |  | Sucrose |  | 0 | -1.397192183 | 1082
 | Choline | 0 | 0 | -2.096536781 | 354 |  |  | Phosphate | ATP |  | -15.1745 | 0.6997623 | 314
Uracil | UTP | -1 | -9.0416 | 1.180584663 | 1205 |  |  |  | ATP |  | -15.1745 | 0.6997623 | 316
 | CTP | -1 | -9.0416 | 0.737528044 | 388 |  |  |  | ATP |  | 0 | 0.6997623 | 317
 | Serine | 0 | 0 | 0.73899016 | 1052 |  |  |  | ATP |  | 0 | 0.6997623 | 318
 |  |  |  |  |  |  |  |  | ATP |  | 0 | 0.6997623 | 319
 |  |  |  |  |  |  |  |  | ATP |  | 0 | 0.6997623 | 320
 |  |  |  |  |  |  |  |  | Ribose-phosphate |  | -5.0582 | 2.035591456 | 1031
 |  |  |  |  |  |  |  |  | Ribose-phosphate |  | -5.0582 | 2.035591456 | 1032
 |  |  |  |  |  |  |  |  | D-sedoheptulose-7-phosphate |  | -5.0582 | 1.470061686 | 1043
 |  |  |  |  |  |  |  |  | 6-phospho-d-gluconate |  | -5.0582 | 2.325754767 | 171
 |  |  |  |  |  |  |  |  | NAD+ |  | 0 | 0.38 | 841
 |  |  |  |  |  |  |  |  | NAD+ |  | 0 | 0.38 | 844
 |  |  |  |  |  |  |  |  | Fructose-1,6-bisphosphate |  | -10.1163 | 2.590906528 | 510
 |  |  |  |  |  |  |  |  | UDP-D-glucose |  | -10.1163 | 0.77245413 | 1191
 |  |  |  |  |  |  |  |  | N-acetyl-glucosamine-1-phosphate |  | -5.0582 | 1.54 | 219
 |  |  |  |  |  |  |  |  | CTP |  | -15.1745 | 0.718712663 | 388
 |  |  |  |  |  |  |  |  | CTP |  | -10.1163 | 0.718712663 | 389
 |  |  |  |  |  |  |  |  | UTP |  | -15.1745 | 1.126480962 | 1205
 |  |  |  |  |  |  |  |  | UTP |  | 0 | 1.126480962 | 1206
 |  |  |  |  |  |  |  |  | Choline |  | 0 | -1.895886942 | 354
 |  |  |  |  |  |  |  |  | Deoxyguanosine |  | 0 | -1.318965371 | 432
 |  |  |  |  |  |  |  |  | Cytosine |  | 0 | -1.849070073 | 386
 |  |  |  |  |  |  |  |  | [NAME] |  | 0 | -2.111004263 | 606
 |  |  |  |  |  |  |  |  | [NAME] |  | 0 | -2.111004263 | 608
 |  |  |  |  |  |  |  |  | Adenosine |  | 0 | -1.386737341 | 235
 |  |  |  |  |  |  |  |  | Adenosine |  | 0 | -1.386737341 | 237
 |  |  |  |  |  |  |  |  | Cytidine |  | 0 | -1.835201644 | 395
 |  |  |  |  |  |  |  |  | Inosine |  | 0 | -2.747895523 | 727
 |  |  |  |  |  |  |  | Leucine | Nicotinate | 0 | 0 | 1.216210256 | 837
 |  |  |  |  |  |  |  |  | Nicotinate | 0 | 0 | 1.216210256 | 839
 |  |  |  |  |  |  |  |  | Pyruvate | 0 | 0 | -0.486558139 | 1023
 |  |  |  |  |  |  |  |  | Pyruvate | 0 | 0 | -0.486558139 | 1025
 |  |  |  |  |  |  |  |  | Pyruvate | 0 | 0 | -0.486558139 | 1026
 |  |  |  |  |  |  |  |  | Phenylpyruvate | 0 | 0 | -1.408510173 | 957
 |  |  |  |  |  |  |  |  | Choline | 0 | 0 | -2.096536781 | 354
 |  |  |  |  |  |  |  | Uracil | UTP |  | -9.0416 | 1.180584663 | 1205
 |  |  |  |  |  |  |  |  | CTP |  | -9.0416 | 0.737528044 | 388
 |  |  |  |  |  |  |  |  | CTP |  | 0 | 0.737528044 | 389
 |  |  |  |  |  |  |  |  | Serine |  | 0 | 0.73899016 | 1052
 |  |  |  |  |  |  |  |  | Serine |  | 0 | 0.73899016 | 1054