Spreadsheet: 0ccf644e-6001-436a-b7af-79160857e6ea
Sheet: Sheet1

Unnamed: 0 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7
Accession | Fold | Protein name | length | subcellular location | function | [NAME] | mw
P27352 | 12 | Gastric intrinsic factor (Intrinsic factor) (INF) (IF) | 417 | Secreted. | FUNCTION: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum by specific receptor-mediated endocytosis. | GF (FMH) | 45416
P01037 | 12 | Cystatin-SN (Cystatin-1) ([NAME] cystatin-SA-1) (Cystain-SA-I) | 141 | Secreted. | FUNCTION: Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. [NAME], with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is [NAME], although both inhibit ficin equally well.  Note.  found as a new diagnostic marker for colon cancer.  found to be highly methylated in breast cancer cell | CST1 | 16362
[NAME] | 11 | Carboxypeptidase A2 (EC 3.4.17.15) | 417 | Secreted. |  | CPA2 | 46828
P35326 | 7 | Small proline-rich protein 2A (SPR-2A) (2-1) | 72 | Cytoplasm. | FUNCTION: Cross-linked envelope protein of [NAME] is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.i | SPRR2A | 7965
Q9UGM3 | 6 | Deleted in malignant brain tumors 1 protein ([NAME] 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein) (Hensin) | 2413 | Secreted. | FUNCTION: May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation (By similarity) | DMBT1 (GP340) | 260735
Q2M2E0 | 6 | Cadherin 17, (Cadherin 17, LI cadherin (Liver-intestine)) | 832 | i | Note.  Also called liver-intestine cadherin. Calcium-dependent transmembrane glycooprotein that mediates cell-cell adhesion in intestinal epithelium. Was reported in gastric, pancreatic and colorectal adenocarcinoma | CDH17 | 92206
P40199 | 6 | Carcinoembryonic antigen-related cell adhesion molecule 6 (Normal cross-reacting antigen) (Non-specific crossreacting antigen) (CD antigen CD66c) | 344 | Cell membrane; Lipid-anchor â€º GPI-anchor. |  | CEACAM6 (NCA) | 37237
Q53FA8 | 6 | Chromogranin A variant (Fragment) | 457 | 50674
Q6FHJ7 | 6 | Secreted frizzled-related protein 4 (sFRP-4) (Frizzled protein, human endometrium) (FrpHE) | 346 | Secreted. | FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function.ncreases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptakei | SFRP4 (FRPHE) | 39827
Q6ZMH5 | 6 | Zinc transporter [NAME] (Zrt- and Irt-like protein 5) ([NAME]) (Solute carrier family 39 member 5) | 539 | Basolateral cell membrane; Multi-pass membrane protein. | FUNCTION: May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Seems to play a central role in controlling organismal zinc status (By similarity).i | SLC39A5 (ZP5) | 56330
Q9BZP6 | 5 | Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (TSA1902) | 476 | Secreted.  Cytoplasm.  Cytoplasm. | FUNCTION: Degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogensi | CHA | 52271
Q6UX06 | 5 | Olfactomedin-4 (OLM4) (G-CSF-stimulated clone 1 protein) (hGC-1) (hOLfD) (Antiapoptotic protein [NAME]) | 510 | Secreted â€º extracellular space. | FUNCTION: An antiapoptotic factor that promotes tumor growth. Promotes proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. Facilitates cell adhesioni | OLFM4 ([NAME]) (UNQ362/PRO698) | 57280
Q99795 | 5 | Cell surface A33 antigen ([NAME]) | 319 | Membrane; Single-pass type I membrane protein. | FUNCTION: May play a role in cell-cell recognition and signalingi | GPA33 | 35632
Q53F21 | 5 | Lipase, gastric variant (Fragment) | 398 |  |  |  | 45181
P08254 | 5 | Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) | 477 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase | MMP3 (STMY1) | 53977
Q99972 | 5 | Myocilin (Trabecular meshwork-induced glucocorticoid response protein) | 504 | Rough endoplasmic reticulum. Secreted. Cell projection â€º cilium. | FUNCTION: May participate in the obstruction of fluid outflow in the trabecular meshwork | MYOC (GLC1A) (TGR) | 56972
P19957 | 5 | Elafin (Elastase-specific inhibitor) (ESI) (Skin-derived antileukoproteinase) (SKALP) (Peptidase inhibitor 3) (WAP four-disulfide core domain protein 14) (Protease inhibitor [NAME]) | 117 | Secreted. | FUNCTION: Neutrophil and pancreatic elastase-specific inhibitor of [NAME] may prevent elastase-mediated tissue proteolysis | P3 ([NAME]) (WFDC14) | 12270
Q8WUJ3 | 5 | Protein KIAA1199i | 1361 | i | FUNCTION: May be involved in hearingi | KAA1199 | 152998
O43915 | 5 | Vascular endothelial growth factor D (VEGF-D) (c-fos-induced growth factor) (FIGF) | 354 | Secreted. | FUNCTION: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (Flk1) and VEGFR-3 (Flt4) receptorsi | FGF (VEGFD) | 40444
O43653 | 5 | Prostate stem cell antigeni | 123 | Cell membrane; Lipid-anchor â€º GPI-anchor. | FUNCTION: May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitroi | PSCA (UNQ206/PRO232) | 12912
P25092 | 4 | Heat-stable enterotoxin receptor (STA receptor) (hSTAR) (EC 4.6.1.2) (Intestinal guanylate cyclase) (GC-C) | 1073 | Membrane; Single-pass type I membrane protein. | FUNCTION: Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide [NAME] | GUCY2C (GUC2C) (STAR) | 123369
Q6ISS4 | 4 | Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) (CD antigen CD306) | 152 | Secreted. | Note. Function is not known, but is thought to be secreted and may help modulate mucosal tolerance. This has been detected in urine of pregnant women in high amounts.  LAIR-2 competes with LAIR-1 to bind to the collagen.  LAIR-2 may function as a proinflammatory mediator by decreasing the inhibitory potential of the immune inhibitor LAIR-1, resulting in more highly activated immune cells.  Thus, LAIR-2 regulate the inhibitory potential of the membrane-bound hLAIR-1 via competing for the same ligands. | LAR2 (CD306) | 16280
Q8NAB7 | 4 | cDNA [NAME] fis, clone SPLEN2011805, highly similar to BONE/CARTILAGE PROTEOGLYCAN Ii | 325 |  |  |  | 36637
[NAME] | 4 | Seprase (EC 3.4.21.-) (Fibroblast activation protein alpha) (Integral membrane serine protease) (170 [NAME] melanoma membrane-bound gelatinase) | 760 | Cell membrane; Single-pass type II membrane protein. Cell projection â€º lamellipodium membrane; Single-pass type II membrane protein. Cell projection â€º invadopodium membrane; Single-pass type II membrane protein. | FUNCTION: May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancersi | FAP | 87739
P35443 | 4 | Thrombospondin-4i | 961 | i | FUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collageni | THBS4 (TSP4) | 105869
P35442 | 4 | Thrombospondin-2i | 1172 | i | FUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collageni | THBS2 (TSP2) | 129991
P10451 | 4 | [NAME] (Bone sialoprotein 1) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin) | 314 | Secreted. | FUNCTION: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.CC    FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity).i | SPP1 (BNSP) (OPN) (PSEC0156) | 35423
Q96CG8 | 4 | Collagen triple helix repeat-containing protein 1 ([NAME] protein) | 243 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: May act as a negative regulator of collagen matrix deposition (By similarity).i | [NAME] (UNQ762/PRO1550) | 26224
Q13087 | 4 | Protein disulfide-isomerase A2 (EC 5.3.4.1) (PDIp) | 525 | Endoplasmic reticulum lumen. | i | PDA2 (PDP) | 58206
Q6L7A0 | 4 | [NAME] transcript variant ci | 218 | i | i | AQP4 | 23623
P55001 | 4 | Microfibrillar-associated protein 2 (MFAP-2) (Microfibril-associated glycoprotein 1) ([NAME]) (MAGP) | 183 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Component of the elastin-associated microfibrilsi | MFAP2 (MAGP1) | 20826
P36222 | 4 | Chitinase-3-like protein 1 (Cartilage glycoprotein 39) (CGP-39) ([NAME]) ([NAME]) (39 [NAME] synovial protein) (YKL-40) | 383 | Secreted â€º extracellular space. | FUNCTION: May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens.i | CH3L1 | 42625
[NAME] | 3 | [NAME] 3 preproprotein (Kallikrein 1, renal/pancreas/salivary, isoform [NAME]) | 172 | i | i | KLK1 (hCG_22931) | 19239
Q99715 | 3 | Collagen alpha-1(XII) chaini | 3063 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity).  Note.  biological process involved in cell growth and maintenancei | COL12A1 (COL12A1L) | 333147
P22223 | 3 | Cadherin-3 (Placental cadherin) (P-cadherin) | 829 | Cell membrane; Single-pass type I membrane protein. | FUNCTION: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.i | CDH3 (CDHP) | 91418
[NAME] | 3 | ORM2 proteini | 201 | i | i | ORM2 | 23615
Q8NFT8 | 3 | Delta and Notch-like epidermal growth factor-related receptori | 737 | Cell membrane; Single-pass type I membrane protein. | FUNCTION: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).  Note.  Notch families signaling pathways have been shown to function in the control of stem cell populations in adult tissues.  Dysregulation of signaling in these popualtions frequently leads to malignant transformation.  Interaction of Notch receptors w/ ligands Delta0like or jagged leads to proteolytic cleavage and release of the active intracellular domain of Notch, which translocates to the nucleus where it interacts with transcriptional regulators.i | DNER (BET) (UNQ262/PRO299) | 78475
Q9NS71 | 3 | Gastrokine-1 (18 kDa antrum mucosa protein) (AMP-18) (Protein CA11) | 199 | Secreted. | FUNCTION: Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epitheliumi | GKN1 (AMP18) (CA11) (UNQ489/PRO1005) | 21999
Q8WW62 | 3 | Transmembrane emp24 domain-containing protein 6i | 240 | Endoplasmic reticulum membrane; Single-pass type I membrane protein. | i | TMED6 (UNQ9146/PRO34237) | 27631
P25311 | 3 | Zinc-alpha-2-glycoprotein (Zn-alpha-2-glycoprotein) (Zn-alpha-2-GP) | 295 | Secreted. | FUNCTION: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty [NAME] | AZGP1 (ZAG) (ZNGP1) | 33872
P23352 | 3 | Anosmin-1 ([NAME] syndrome protein) (Adhesion molecule-like X-linked) | 680 | Cell surface. | FUNCTION: May be an adhesion-like molecule with anti-protease activityi | KAL1 (ADMLX) (KAL) (KALG1) | 76112
O95450 | 3 | A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS-2) (ADAM-TS 2) (ADAM-TS2) (EC 3.4.24.14) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI) | 1211 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesisi | ADAMTS2 (PCNP) (PCPN) | 134755
[NAME] | 3 | [NAME] (Tyrosine-rich acidic matrix protein) (TRAMP) | 201 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity.nhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity) | DPT | 24005
P02452 | 3 | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | 1464 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Type I collagen is a member of group I collagen (fibrillar forming collagen) | COL1A1 | 138911
P19801 | 3 | Amiloride-sensitive amine oxidase [copper-containing] (Diamine oxidase) (DAO) (EC 1.4.3.22) (Amiloride-binding protein) (ABP) (Histaminase) (Kidney amine oxidase) (KAO) | 751 | Secreted â€º extracellular space. | FUNCTION: Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive functioni | [NAME] ([NAME]) ([NAME]) | 85342
Q03403 | 3 | Trefoil factor 2 (Spasmolytic polypeptide) (SP) (Spasmolysin) | 129 | Secreted. | FUNCTION: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).i | TFF2 (SML1) | 14284
Q9Y5X9 | 3 | Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL) | 500 | Secreted. | FUNCTION: Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.  Note.  Not sure what function it has. Maybe cancer cells have high expression of endothelial lipasei | [NAME] (UNQ387/PRO719) | 56795
Q03692 | 3 | [NAME]) chaini | 680 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Type X collagen is a product of hyperthrophic chondrotocytes and has been localized to presumptive mineralization zones of hyaline cartilage.i | COL10A1 | 66158
Q96IQ7 | 3 | V-set and immunoglobulin domain-containing protein 2 (CT-like protein) (Cortical thymocyte-like protein) | 327 | Membrane; Single-pass type I membrane protein. | Note.  Was identified as a marker for gastric cancer in previous studiesi | VSG2 (CTH) (CTXL) (UNQ2770/PRO7154) | 34348
Q8IWU6 | 3 | Extracellular sulfatase Sulf-1 (EC 3.1.6.-) (HSulf-1) | 871 | Endoplasmic reticulum. Golgi apparatus â€º Golgi stack. Cell surface. | FUNCTION: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity.t can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. [NAME] (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.  Note.  down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines. (another study suggest otherwise). found in bloodi | [NAME] (KAA1077) | 101027
P04216 | 3 | Thy-1 membrane glycoprotein (Thy-1 antigen) (CDw90) (CD antigen CD90) | 161 | Cell membrane; Lipid-anchor â€º GPI-anchor. | FUNCTION: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the braini | [NAME] | 17935
O95388 | 3 | WNT1-inducible-signaling pathway protein 1 (WISP-1) (Wnt-1-induced secreted protein) | 367 | Secreted. | FUNCTION: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts.n vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycani | WSP1 (CCN4) | 40331
Q8IXT1 | 3 | Nitric oxide-inducible gene proteini | 998 | Cytoplasm. Nucleus. | FUNCTION: Acts as an anti-apoptotic factor and its absence increases cell death under normal and stress conditions. Can induce cell cycle arrest in the G1 or early S phase and this activity is independent of TP53/p53 (By similarity).i | NOXN (C11orf82) | 111616
P02774 | 3 | Vitamin D-binding protein (DBP) (VDB) (Group-specific component) (Gc-globulin) | 474 | Secreted. | FUNCTION: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types.n plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytesi | GC | 52964
O00300 | 3 | Tumor necrosis factor receptor superfamily member 11B (Osteoprotegerin) (Osteoclastogenesis inhibitory factor) | 401 | Secreted. | FUNCTION: Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis.nhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesisi | TNFRSF11B (OCF) (OPG) | 46040
Q86XP6 | 3 | Gastrokine-2 ([NAME]) (Trefoil factor interactions(z) 1) (Down-regulated in gastric cancer) | 184 | Secreted. | i | GKN2 (BLOT) (GDDR) (TFZ1) (UNQ465/PRO813) | 20487
Q8IUX8 | 3 | EGF-like domain-containing protein 6 (Multiple EGF-like domain protein 6) (Multiple epidermal growth factor-like domain protein 6) (MAM and EGF domains-containing gene protein) | 553 | Secreted â€º extracellular space â€º extracellular matrix â€º basement membrane. | FUNCTION: May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | EGFL6 (MAEG) (PP648) (UNQ281/PRO320) | 61317
Q96LR4 | 3 | Protein FAM19A4 (Chemokine-like protein TAFA-4) | 140 | Secreted. | i | FAM19A4 (TAFA4) | 15682
O43184 | 3 | ADAM 12 (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin-alpha) | 909 | Cell membrane; Single-pass type I membrane protein.  Secreted.  Secreted.  Secreted. | FUNCTION: Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity) | ADAM12 (MLTN) (UNQ346/PRO545) | 99641
Q13421 | 3 | [NAME] (Pre-pro-megakaryocyte-potentiating factor) (CAK1 antigen) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form]i | 630 | Cell membrane; Lipid-anchor â€º GPI-anchor. Golgi apparatus.  Secreted.  Secreted. | FUNCTION: Membrane-anchored forms may play a role in cellular adhesion.CC    FUNCTION: Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitroi | [NAME] (MPF) | 68986
P09544 | 3 | Protein Wnt-2 (Int-1-related protein) (IRP protein) | 360 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues.s likely to signal over only few cell diametersi | WNT2 (NT1L1) (RP) | 40418
Q53GF1 | 3 | Matrix metalloproteinase 7 preproprotein variant (Fragment) | 267 |  |  |  | 29598
Q9HBP0 | 3 | Putative uncharacterized proteini | 426 |  |  |  | 47454
Q59HB5 | 3 | Alpha 1 type XI collagen isoform C preproprotein variant (Fragment) | 1017 | 99966
Q9NRD8 | 3 | Dual oxidase 2 (EC 1.6.3.1) (EC 1.11.1.-) (NADPH oxidase/peroxidase [NAME]) (NADPH thyroid oxidase 2) (Large NOX 2) (Long NOX 2) ([NAME] oxidase 2) (NADH/NADPH thyroid oxidase p138-tox) (p138 thyroid oxidase) | 1548 | Apical cell membrane; Multi-pass membrane protein. | FUNCTION: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domaini | [NAME] (LNOX2) (THOX2) | 175363
O75556 | 3 | Mammaglobin-B (Mammaglobin-2) (Lipophilin-C) ([NAME]) ([NAME] family 2A member 1) | 95 | i | FUNCTION: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.i | SCGB2A1 (LPHC) ([NAME]) (UGB3) | 10884
Q99650 | 2 | Oncostatin-M specific receptor subunit betai | 979 | Membrane; Single-pass type I membrane protein. | FUNCTION: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling eventsi | OSMR (OSMRB) | 110509
P42702 | 2 | Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen [NAME]) | 1097 | Cell membrane; Single-pass type I membrane protein.  Secreted. | FUNCTION: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.i | LFR | 123743
Q8N8U9 | 2 | BMP-binding endothelial regulator protein (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2) | 685 | Secreted. | FUNCTION: Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytesi | BMPER ([NAME]) | 75997
P31997 | 2 | Carcinoembryonic antigen-related cell adhesion molecule 8 (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD67 antigen) (CD antigen CD66b) | 349 | Cell membrane; Lipid-anchor â€º GPI-anchor. | Note.nvolved in the control of proliferation in hematopoietic and epithelial cells and acts as a tumor supressori | CEACAM8 (CGM6) | 38154
P78324 | 2 | Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) ([NAME]) (Inhibitory receptor [NAME]) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha-3) (MyD-1 antigen) ([NAME] molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) ([NAME] antigen-like family member A) (CD antigen CD172a) | 503 | Membrane; Single-pass type I membrane protein. | FUNCTION: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity).nvolved in the negative regulation of receptor [NAME]-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.  Note.  downregulated in oncogene, suppression of cancer cells.  in other cancer cells, this is down-regulated (breast cancer)  Extracellular region seems to take part in inhibitory effect.  Suppressing effecti | SRPA (BT) (MFR) (MYD1) (PTPNS1) ([NAME]) (SRP) | 54813
P16422 | 2 | Tumor-associated calcium signal transducer 1 (Major gastrointestinal tumor-associated protein GA733-2) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Adenocarcinoma-associated antigen) (KSA) (KS 1/4 antigen) (Cell surface glycoprotein Trop-1) (CD antigen CD326) | 314 | Membrane; Single-pass type I membrane protein. | FUNCTION: GA733 tumor-associated antigen gene family may function as growth factor receptors.  Note.  Expressed in colorectal carcinoma cells, pancreatic carcinoma cells, lung and colon adenocarcinoma.  Calcium independen cell adhesion mollecule.  i | TACSTD1 (GA733-2) (M1S2) (M4S1) (MC18) (TROP1) | 34932
[NAME] | 2 | Neurexin-3-alpha ([NAME]) | 1643 | Membrane; Single-pass type I membrane protein. | FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.i | NRXN3 ([NAME]) | 180599
P09486 | 2 | SPARC (Secreted protein acidic and rich in cysteine) ([NAME]) (ON) (Basement-membrane protein 40) (BM-40) | 303 | Secreted â€º extracellular space â€º extracellular matrix â€º basement membrane. | FUNCTION: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinityi | SPARC (ON) | 34632
P10153 | 2 | Non-secretory ribonuclease (EC 3.1.27.5) ([NAME]) ([NAME]-derived neurotoxin) (RNase UpI-2) ([NAME]) (RNase 2) | 161 | Lysosome. Cytoplasmic granule. | FUNCTION: This is a non-secretory ribonuclease.t is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activitiesi | RNASE2 (EDN) (RNS2) | 18354
Q9HC56 | 2 | Protocadherin-9i | 1237 | Cell membrane; Single-pass type I membrane protein. | FUNCTION: Potential calcium-dependent cell-adhesion protein. | PCDH9 | 136064
Q12860 | 2 | Contactin-1 (Neural cell surface protein F3) (Glycoprotein gp135) | 1018 | Cell membrane; Lipid-anchor â€º GPI-anchor; Extracellular side.  Cell membrane; Lipid-anchor â€º GPI-anchor; Extracellular side. | FUNCTION: Contactins mediate cell surface interactions during nervous system development.nvolved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1.ts association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus.nteraction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity) | CNTN1 | 113320
Q96RW7 | 2 | Hemicentin-1 (Fibulin-6) (FIBL-6) | 5635 | Secreted â€º extracellular space â€º extracellular matrix â€º basement membrane. | Note.  Cause age related macular degenerate type 1.  irreversible vision loss (dye disease) | HMCN1 (FBL6) | 613390
Q53G30 | 2 | Carcinoembryonic antigen-related cell adhesion molecule 5 variant (Fragment) | 702 |  |  |  | 76868
[NAME] | 2 | KIRREL protein (Kin of IRRE like (Drosophila)) (Kin of IRRE like (Drosophila), isoform [NAME]) | 757 | i | According to NCBI.  Is a member of the nephrin-like protein family.  The cytoplasmic domains of these proteins interact with the C terminus of podocin. Expressed in kidney podocytes, ensure size- charge- selective ultrafiltration  Note.  [NAME] domain cell adhesion molecule subfamily (maybe has to do with the cell adhesion?) | [NAME] (RP11-444M10.2-001) (hCG_39953) | 83536
Q8TF66 | 2 | Leucine-rich repeat-containing protein 15 (hLib) | 581 | Membrane; Single-pass type I membrane protein. | i | LRRC15 (LB) | 64396
P55290 | 2 | [NAME] ([NAME] cadherin) (T-cadherin) (T-cad) (Heart cadherin) (H-cadherin) (P105) | 713 | Cell membrane; Lipid-anchor â€º GPI-anchor. | FUNCTION: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growthi | [NAME] (CDHH) | 78287
P17301 | 2 | Integrin alpha-2 (Platelet membrane glycoprotein Ia) (GPIa) (Collagen receptor) (VLA-2 alpha chain) (CD49 antigen-like family member B) (CD antigen CD49b) | 1181 | Membrane; Single-pass type I membrane protein. | FUNCTION: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin.t recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.t is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrixi | TGA2 (CD49B) | 129295
Q9UKZ9 | 2 | [NAME] enhancer 2 (Procollagen COOH-terminal proteinase enhancer 2) ([NAME] enhancer 2) (PCPE-2) | 415 | Secreted. | FUNCTION: Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1i | PCOLCE2 (PCPE2) (UNQ250/PRO287) | 45717
P25815 | 2 | Protein S100-P (S100 calcium-binding protein P) | 95 | Nucleus. Cytoplasm. | i | S100P (S100E) | 10400
P17643 | 2 | 5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA oxidase) (EC 1.14.18.-) (Tyrosinase-related protein 1) (TRP-1) ([NAME]) (TRP) (Catalase B) ([NAME] 75) (Melanoma antigen [NAME]) | 537 | Melanosome membrane; Single-pass type I membrane protein. | FUNCTION: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesizedi | TYRP1 (CAS2) (TYRP) (TYRRP) | 60724
Q53HV3 | 2 | Lysyl oxidase-like 2 variant (Fragment) | 774 |  |  |  | 86635
Q14956 | 2 | Transmembrane glycoprotein NMB ([NAME] glycoprotein HGFIN) | 572 | Membrane; Single-pass type I membrane protein. Melanosome. | FUNCTION: Could be a melanogenic enzyme (By similarity) | GPNMB (HGFN) (NMB) (UNQ1725/PRO9925) | 63923
Q9Y5C1 | 2 | Angiopoietin-related protein 3 (Angiopoietin-like 3) (Angiopoietin-5) (ANG-5) | 460 | Secreted. | Note.  Cell growth, cell surfce bindingi | ANGPTL3 (ANGPT5) (UNQ153/PRO179) | 53637
[NAME] | 2 | APOC2 proteini | 72 | i | i | APOC2 | 8146
Q96AY3 | 2 | FK506-binding protein 10 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (Immunophilin FKBP65) (65 kDa FK506-binding protein) (FKBP65) | 582 | Endoplasmic reticulum lumen. | FUNCTION: PPIases accelerate the folding of proteins during protein synthesis. Note. Regulate multiple signaling pathways, including mTOR.  activation of mTOR in the pathogenesis of melanoma, and suggest that [NAME] and mTOR may be targets for melanoma therapi | FKBP10 (FKBP65) (PSEC0056) | 64245
P02751 | 2 | Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Ugl-Y1; Ugl-Y2; Ugl-Y3]i | 2386 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.nteraction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity). Note.  found high expressing in luncg carcinoma.  i | FN1 (FN) | 262607
Q969Z4 | 2 | Tumor necrosis factor receptor superfamily member 19L (Receptor expressed in lymphoid tissues) | 430 | Cell membrane; Single-pass type I membrane protein. Cytoplasm. | FUNCTION: Mediates activation of NF-kappa-B. May play a role in T- cell activation.i | RELT (TNFRSF19L) | 46092
Q68BL8 | 2 | Olfactomedin-like protein 2B (Photomedin-2) | 750 | Secreted. | i | OLFML2B | 83999
P29323 | 2 | Ephrin type-B receptor 2 (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (Tyrosine-protein kinase TYRO5) (Renal carcinoma antigen NY-REN-47) | 1055 | Membrane; Single-pass type I membrane protein. | FUNCTION: Receptor for members of the ephrin-B family. Acts as a tumor suppressori | EPHB2 (DRT) (EPHT3) (EPTH3) (ERK) (HEK5) (TYRO5) | 117493
P27487 | 2 | Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (Adenosine deaminase complexing protein 2) (ADABP) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]i | 766 | Secreted.  Cell membrane; Single-pass type II membrane protein. | FUNCTION: Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Plays a role in T-cell activationi | [NAME] (ADCP2) (CD26) | 88279
Q9BUG9 | 2 | Integrin betai | 439 | Membrane; Single-pass type I membrane protein. | i | TGB8 (hCG_37311) | 48419
Q549C7 | 2 | Transthyretin (Transthyretin (Prealbumin, amyloidosis type I), isoform [NAME]) (cDNA, FLJ92332, Homo sapiens transthyretin (prealbumin, amyloidosis type I) (TTR),mRNA) | 147 | i | i | [NAME] (hCG_25470) | 15887
Q7Z304 | 2 | MAM domain-containing protein 2 (MAM domain-containing proteoglycan) (Mamcan) | 686 | Secreted â€º extracellular space â€º extracellular matrix. | i | MAMDC2 | 77583
Q16270 | 2 | Insulin-like growth factor-binding protein 7 (IGF-binding protein 7) (IGFBP-7) (IBP-7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1) (Tumor-derived adhesion factor) (TAF) | 282 | Secreted. | FUNCTION: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesioni | GFBP7 (MAC25) (PSF) | 29130
Q9NZC2 | 2 | Triggering receptor expressed on myeloid cells 2 (Triggering receptor expressed on monocytes 2) (TREM-2) | 230 | Cell membrane; Single-pass type I membrane protein.  Secreted.  Secreted. | FUNCTION: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cellsi | TREM2 | 25447
Q6UW01 | 2 | Cerebellin-3i | 205 | Secreted. Cell junction â€º synapse. | FUNCTION: May be involved in synaptic functions in the CNSi | CBLN3 (UNQ755/PRO1486) | 21521
Q14114 | 2 | Low-density lipoprotein receptor-related protein 8 (Apolipoprotein E receptor 2) | 963 | Cell membrane; Single-pass type I membrane protein. Secreted. | FUNCTION: Cell surface receptor for [NAME] (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular [NAME] signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. [NAME] acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for [NAME] than VLDLR. LRP8 is thus a key component of the [NAME] pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptori | LRP8 (APOER2) | 105662
P05997 | 2 | [NAME]) chaini | 1499 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Type V collagen is a member of group I collagen (fibrillar forming collagen).t is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue- specific matrices (By similarity) | COL5A2 | 144910
Q9NR99 | 2 | Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican) | 2828 | Secreted. | i | MXRA5 | 312280
Q9NQ36 | 2 | Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein CEGP1) | 999 | i | i | SCUBE2 (CEGP1) | 109957
Q5ZPR3 | 2 | CD276 antigen (Costimulatory molecule) (B7 homolog 3) ([NAME]) (4Ig-B7-H3) (CD antigen CD276) | 534 | Membrane; Single-pass type I membrane protein. | FUNCTION: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses.soform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signalingi | CD276 (B7H3) (PSEC0249) (UNQ309/PRO352) | 57235
P13284 | 2 | Gamma-interferon-inducible lysosomal thiol reductase (Gamma-interferon-inducible protein IP-30) | 261 | Lysosome. | FUNCTION: Cleaves disulfide bonds in proteins by reduction. May facilitate the complete unfolding of proteins destined for lysosomal degradation. May be involved in MHC class II-restricted antigen processingi | F30 (GLT) | 29149
P15018 | 2 | Leukemia inhibitory factor (LIF) (Differentiation-stimulating factor) (D factor) (Melanoma-derived LPL inhibitor) (MLPLI) ([NAME]) | 202 | Secreted. | FUNCTION: LIF has the capacity to induce terminal differentiation in leukemic cells.ts activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytesi | LF (HLDA) | 22008
P58397 | 2 | A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS-12) (ADAM-TS 12) (ADAM-TS12) (EC 3.4.24.-) | 1593 | Secreted â€º extracellular space â€º extracellular matrix. | i | ADAMTS12 (UNQ1918/PRO4389) | 177545
Q9UBX7 | 2 | [NAME] (hK11) (EC 3.4.21.-) (Hippostasin) (Trypsin-like protease) ([NAME] protease 20) [Cleaved into: Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2]i | 282 | Secreted. | FUNCTION: Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residuesi | KLK11 (PRSS20) (TLSP) (UNQ649/PRO1279) | 31059
[NAME] | 2 | [NAME]-like protein 2 (Chordin-related protein 2) (Breast tumor novel factor 1) (BNF-1) | 429 | Secreted.  Secreted.  Cytoplasm.  Cytoplasm.  Cytoplasm. | FUNCTION: May inhibits BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity).mplicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturationi | CHRDL2 (BNF1) (CHL2) (UNQ765/PRO1557) | 47495
P02462 | 2 | Collagen alpha-1(IV) chain (Arresten) | 1669 | Secreted â€º extracellular space â€º extracellular matrix â€º basement membrane. | FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits endothelial cell proliferation and angiogenesis.nhibits angiogenesis potentially via mechanisms involving cell surface proteoglycans and the alpha and beta integrins of endothelial cellsi | COL4A1 | 160615
Q6UW10 | 2 | Surfactant-associated protein 2 (Surfactant-associated protein G) | 78 | Secreted. | i | SFTA2 (SFTPG) (UNQ541/PRO1098) | 8396
Q96RL6 | 2 | Sialic acid-binding Ig-like lectin 11 (Sialic acid-binding lectin 11) (Siglec-11) | 686 | Membrane; Single-pass type I membrane protein. | FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.n the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling moleculesi | SGLEC11 (UNQ9222/PRO28718) | 74544
P08123 | 2 | [NAME]) chain (Alpha-2 type I collagen) | 1366 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Type I collagen is a member of group I collagen (fibrillar forming collagen) | COL1A2 | 129288
O60687 | 2 | Sushi repeat-containing protein SRPX2i | 465 | Secreted. | FUNCTION: May have a role in the perisylvian region, critical for language and cognitive developmenti | SRPX2 (SRPUL) | 52972
P15428 | 2 | 15-hydroxyprostaglandin dehydrogenase [NAD+] (PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) | 266 | Cytoplasm. | FUNCTION: Inactivation of prostaglandinsi | HPGD (PGDH1) | 28977
P04155 | 2 | Trefoil factor 1 (pS2 protein) (HP1.A) (Breast cancer estrogen-inducible protein) (PNR-2) | 84 | Secreted. | FUNCTION: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urinei | TFF1 (BCE) (PS2) | 9150
[NAME] | 2 | Nidogen-2 (NID-2) (Osteonidogen) | 1375 | Secreted â€º extracellular space â€º extracellular matrix â€º basement membrane. | FUNCTION: Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins.t probably has a role in cell-extracellular matrix interactions.  Note.n cancer cells, CpG islands of NID2 are aberrantly methylated, result in loss of gene transcription.n previous study, the NID2 promoter was found to be methylated in 29% of colon and 95% of gastric cancers.  Suggesting, the loss of NID2 expression has a potential pathogenetic role in colon and stomach tumorigenesii | ND2 | 151395
Q96SM3 | 2 | Probable carboxypeptidase X1 (EC 3.4.17.-) (Metallocarboxypeptidase CPX-1) | 734 | Secreted. | FUNCTION: May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).i | CPXM1 (CPX1) (CPXM) (UNQ3015/PRO9782) | 81668
[NAME] | 2 | Mucin-13 (MUC-13) (Down-regulated in colon cancer 1) | 512 | Cell membrane; Single-pass type I membrane protein. Secreted. | FUNCTION: Epithelial and hemopoietic transmembrane mucin that may play a role in cell signalingi | MUC13 (DRCC1) (RECC) (UNQ6194/PRO20221) | 54604
P39060 | 2 | Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin]i | 1754 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.CC    FUNCTION: Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.i | COL18A1 | 178188
Q9GZN4 | 2 | Brain-specific serine protease 4 (BSSP-4) (EC 3.4.21.-) ([NAME] protease 22) (Serine protease 26) (Tryptase epsilon) | 317 | Secreted. | FUNCTION: Preferentially cleaves the synthetic substrate H-D-Leu- Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNAi | PRSS22 (BSSP4) (PRSS26) (SP001LA) (UNQ302/PRO343) | 33732
O14944 | 2 | Proepiregulin [Cleaved into: [NAME] (EPR)]i | 169 | Secreted â€º extracellular space.  Cell membrane; Single-pass type I membrane protein. | FUNCTION: May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesisi | EREG | 19044
P02461 | 2 | Collagen alpha-1(III) chaini | 1466 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Collagen type III occurs in most soft connective tissues along with type I collagen.i | COL3A1 | 138564
O15393 | 2 | [NAME] protease, serine 2 (EC 3.4.21.-) ([NAME] protease 10) [Cleaved into: [NAME] protease, serine 2 non-catalytic chain; [NAME] protease, serine 2 catalytic chain]i | 492 | Cell membrane; Single-pass type II membrane protein.  Secreted. | i | TMPRSS2 (PRSS10) | 53859
P01033 | 2 | Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases) (TIMP-1) (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) | 207 | Secreted. | FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, [NAME], MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14i | TMP1 (CLG) (TMP) | 23171
P20702 | 2 | Integrin alpha-X ([NAME] adhesion glycoprotein p150,95 alpha chain) ([NAME] adhesion receptor p150,95) ([NAME]) (CD11 antigen-like family member C) (CD antigen CD11c) | 1163 | Membrane; Single-pass type I membrane protein. | FUNCTION: Integrin alpha-X/beta-2 is a receptor for [NAME] recognizes the sequence G-P-R in fibrinogen.t mediates cell-cell interaction during inflammatory [NAME] is especially important in monocyte adhesion and chemotaxisi | TGAX (CD11C) | 127829
P12314 | 2 | High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (CD antigen CD64) | 374 | Cell membrane; Single-pass type I membrane protein. | FUNCTION: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.  Note.  Maybe acts as a suppressor.  i | FCGR1A (FCG1) (FCGR1) (GFR1) | 42632
Q9BQS7 | 2 | Hephaestin (EC 1.-.-.-) | 1158 | Membrane; Single-pass type I membrane protein. | FUNCTION: May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis.mplicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1i | HEPH (KAA0698) (UNQ2562/PRO6242) | 130449
Q6NZX3 | 2 | 5'-nucleotidase, ecto (CD73) | 574 | i | i | NT5E | 63308
Q96D15 | 2 | [NAME] (EF-hand calcium-binding protein RLP49) | 328 | Endoplasmic reticulum lumen. | i | RCN3 (UNQ239/PRO272) | 37493
P22303 | 2 | Acetylcholinesterase (AChE) (EC 3.1.1.7) | 614 | Cell junction â€º synapse. Secreted. Cell membrane; Peripheral membrane protein.  [NAME].  Cell membrane; Lipid-anchor â€º GPI-anchor; Extracellular side. | FUNCTION: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosisi | ACHE | 67796
P22455 | 2 | Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334) | 802 | Membrane; Single-pass type I membrane protein. | FUNCTION: Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. [NAME] | FGFR4 (JTK2) (TKF) | 87954
O75326 | 2 | Semaphorin-7A (Semaphorin-L) ([NAME]) ([NAME]) ([NAME]) ([NAME] human blood group Ag) (JMH blood group antigen) (CDw108) (CD antigen [NAME]) | 666 | Cell membrane; Lipid-anchor â€º GPI-anchor. | FUNCTION: May play an imortant role in the nervous system and in modulating immune functioni | SEMA7A ([NAME]) (SEMAL) | 74824
P09238 | 2 | Stromelysin-2 (SL-2) (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) | 476 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and [NAME] procollagenasei | MMP10 (STMY2) | 54151
P55774 | 2 | C-C motif chemokine 18 (Small-inducible cytokine A18) (Macrophage inflammatory protein 4) (MIP-4) ([NAME] and activation-regulated chemokine) (CC chemokine PARC) (Alternative macrophage activation-associated CC chemokine 1) (AMAC-1) (Dendritic cell chemokine 1) (DC-CK1) [Cleaved into: CCL18(1-68); CCL18(3-69); CCL18(4-69)]i | 89 | Secreted. | FUNCTION: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responsesi | CCL18 (AMAC1) (DCCK1) (MP4) (PARC) (SCYA18) | 9849
Q92824 | 2 | Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) ([NAME] convertase PC5) (Subtilisin/kexin-like protease PC5) (hPC6) (PC6) | 913 | Secreted. | FUNCTION: Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motifi | PCSK5 (PC5) (PC6) | 101649
P56159 | 2 | GDNF family receptor alpha-1 (GFR-alpha-1) (GDNF receptor alpha) (GDNFR-alpha) (TGF-beta-related neurotrophic factor receptor 1) (RET ligand 1) | 465 | Cell membrane; Lipid-anchor â€º GPI-anchor. | FUNCTION: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | [NAME] (GDNFRA) (RETL1) (TRNR1) | 51456
Q6UXB8 | 2 | Peptidase inhibitor 16 (Cysteine-rich secretory protein 9) ([NAME]) (PSP94-binding protein) | 463 | Membrane; Single-pass type I membrane protein. | FUNCTION: Putative serine protease inhibitor (By similarity).i | P16 (CRSP9) (PSPBP) (PSEC0164) (UNQ289/PRO328) | 49471
P05120 | 2 | Plasminogen activator inhibitor 2 (PAI-2) (Placental plasminogen activator inhibitor) ([NAME]) (Urokinase inhibitor) | 415 | Cytoplasm. Secreted â€º extracellular space. | FUNCTION: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1i | SERPNB2 (PA2) ([NAME]) | 46596
P09758 | 2 | Tumor-associated calcium signal transducer 2 (Pancreatic carcinoma marker protein GA733-1) (Cell surface glycoprotein Trop-2) | 323 | Membrane; Single-pass type I membrane protein. | FUNCTION: GA733 tumor-associated antigen gene family may function as growth factor receptorsi | TACSTD2 (GA733-1) (M1S1) (TROP2) | 35709
Q8IWU5 | 2 | Extracellular sulfatase Sulf-2 (EC 3.1.6.-) (HSulf-2) | 870 | Endoplasmic reticulum. Golgi apparatus â€º Golgi stack. Cell surface. | FUNCTION: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity.t can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparini | SULF2 (KAA1247) (UNQ559/PRO1120) | 100455
Q96S86 | 2 | Hyaluronan and proteoglycan link protein 3i | 360 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: May function in hyaluronic acid binding.i | HAPLN3 (EXLD1) (UNQ238/PRO271) | 40894
Q59EQ1 | 2 | Cadherin 11, type 2 isoform 1 preproprotein variant (Fragment) | 798 | Membrane; Single-pass type I membrane protein. | FUNCTION: Cadherins are calcium dependent cell adhesion proteins (By similarity) | 88175
P02649 | 2 | Apolipoprotein E (Apo-E) | 317 | Secreted. | FUNCTION: Mediates the binding, internalization, and catabolism of [NAME] can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.i | APOE | 36154
P43235 | 2 | Cathepsin K (EC 3.4.22.38) ([NAME] O) (Cathepsin X) (Cathepsin O2) | 329 | Lysosome. | FUNCTION: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradationi | CTSK (CTSO) (CTSO2) | 36966
O95711 | 2 | [NAME] antigen 86 (Protein MD-1) | 162 | Secreted â€º extracellular space. | FUNCTION: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production.mportant for efficient CD180 cell surface expression (By similarity) | LY86 (MD1) | 17906
Q8NHJ6 | 2 | [NAME] immunoglobulin-like receptor subfamily B member 4 ([NAME] immunoglobulin-like receptor 5) (LIR-5) (Immunoglobulin-like transcript 3) (ILT-3) (Monocyte inhibitory receptor [NAME]) (CD85 antigen-like family member K) (CD antigen CD85k) | 448 | Cell membrane; Single-pass type I membrane protein. | FUNCTION: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.nvolved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants.nterferes with TNFRSF5- signaling and NF-kappa-B up-regulation.nhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ionsi | LLRB4 (LT3) (LR5) | 49298
Q9Y240 | 2 | C-type lectin domain family 11 member A (Stem cell growth factor) ([NAME] secreted C-type lectin) (p47) (C-type lectin superfamily member 3) | 323 | Cytoplasm. Secreted. | FUNCTION: Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferationi | CLEC11A ([NAME]) (LSLCL) (SCGF) | 35695
Q59FL3 | 2 | Notch homolog 3 variant (Fragment) | 1289 |  |  |  | 134543
P41221 | 2 | Protein Wnt-5ai | 380 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context.n the presence of FZD4, activates beta-catenin signaling.n the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle.nhibits type II collagen expression in chondrocytesi | WNT5A | 42339
P24347 | 2 | [NAME] (SL-3) (ST3) (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11) | 488 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: May play an important role in the progression of epithelial malignancies.i | MMP11 (STMY3) | 54618
O14958 | 2 | Calsequestrin-2 (Calsequestrin, cardiac muscle isoform) | 399 | Sarcoplasmic reticulum lumen. | FUNCTION: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium (By similarity) | CASQ2 | 46436
O14498 | 2 | Immunoglobulin superfamily containing leucine-rich repeat proteini | 428 | Secreted. | i | SLR (UNQ189/PRO215) | 45997
Q92876 | 2 | Kallikrein-6 (EC 3.4.21.-) (Protease M) (Neurosin) (Zyme) (SP59) (Serine protease 9) ([NAME] protease 18) | 244 | Secreted. Nucleus â€º nucleolus. Cytoplasm. Mitochondrion. Microsome. | FUNCTION: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasisi | KLK6 (PRSS18) (PRSS9) | 26856
Q7Z5F4 | 2 | Protease serine 4 isoform Bi | 261 | 28199
Q16790 | 2 | Carbonic anhydrase 9 (EC 4.2.1.1) (Carbonic anhydrase IX) (CA-IX) (CAIX) (Carbonate dehydratase IX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC-associated antigen G250) (pMW1) | 459 | Nucleus. Nucleus â€º nucleolus. Cell membrane; Single-pass type I membrane protein. Cell projection â€º microvillus membrane; Single-pass type I membrane protein. | FUNCTION: Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.i | CA9 (G250) (MN) | 49698
O95389 | 2 | WNT1-inducible-signaling pathway protein 3 (WISP-3) | 354 | Secreted. | FUNCTION: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis.i | WSP3 (CCN6) (UNQ462/PRO790/PRO956) | 39293
[NAME] | 2 | Anthrax toxin receptor 1 (Tumor endothelial marker 8) | 564 | Membrane; Single-pass type I membrane protein. | FUNCTION: Cellular role is not yet knowni | ANTXR1 (ATR) (TEM8) | 62789
Q8IUX7 | 2 | [NAME] enhancer-binding protein 1 (AE-binding protein 1) (Aortic carboxypeptidase-like protein) | 1158 | Secreted.  Cytoplasm. Nucleus. | FUNCTION: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor (By similarity).i | AEBP1 (ACLP) | 130929
Q8NC67 | 2 | [NAME] and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2) | 525 | Membrane; Single-pass type I membrane protein. | FUNCTION: May play a role in the development and/or maintenance of neuronal circuitry (By similarity) | NETO2 (BTCL2) (UNQ1926/PRO4401) | 59393
Q8IZW8 | 2 | Tensin-4 (C-terminal tensin-like protein) | 715 | Cell junction â€º focal adhesion. Cytoplasm â€º cytoskeleton. | FUNCTION: May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3i | [NAME] (CTEN) (PP14434) | 76904
Q32P28 | 2 | [NAME] 1 (EC 1.14.11.7) ([NAME] and proline-enriched proteoglycan 1) (Leprecan-1) (Growth suppressor 1) | 736 | Endoplasmic reticulum. Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and [NAME] be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblastsi | LEPRE1 (GROS1) (P3H1) (PSEC0109) | 83394
P48764 | 2 | Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) | 834 | Membrane; Multi-pass membrane protein. | FUNCTION: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transductioni | [NAME] (NHE3) | 92908
Q5D0C4 | 2 | SERPINE2 protein (Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform [NAME]) | 397 | i | i | SERPNE2 (hCG_21438) | 44000
Q6X4U4 | 2 | Sclerostin domain-containing protein 1 (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1) | 206 | Secreted. | FUNCTION: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, [NAME] and BMP7 in a dose-dependent manneri | SOSTDC1 (USAG1) (CDA019) | 23307
P52797 | 2 | [NAME] (EPH-related receptor [NAME] ligand 3) (LERK-3) ([NAME]) ([NAME]) (EFL-2) | 238 | Cell membrane; Lipid-anchor â€º GPI-anchor. | i | EFNA3 (EFL2) (EPLG3) ([NAME]) | 26350
P51690 | 2 | Arylsulfatase E (ASE) (EC 3.1.6.-) | 589 | Golgi apparatus â€º Golgi stack. | FUNCTION: May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfatesi | ARSE | 65669
P05121 | 2 | Plasminogen activator inhibitor 1 (PAI-1) (PAI) (Endothelial plasminogen activator inhibitor) | 402 | Secreted. | FUNCTION: This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C.ts rapid interaction with TPA may function as a major control point in the regulation of fibrinolysisi | SERPNE1 (PA1) (PLANH1) | 45060
P42830 | 2 | C-X-C motif chemokine 5 (Small-inducible cytokine B5) (Epithelial-derived neutrophil-activating protein 78) (Neutrophil-activating peptide ENA-78) (ENA-78(1-78)) [Cleaved into: ENA-78(8-78); ENA-78(9-78)]i | 114 | Secreted. | FUNCTION: Involved in neutrophil activation.n vitro, ENA-78(8- 78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.i | [NAME] (ENA78) (SCYB5) | 11972
P00746 | 2 | Complement factor D (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin) | 253 | Secreted. | FUNCTION: Factor D cleaves factor B when the latter is complexed with factor [NAME], activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway.ts function is homologous to that of C1s in the classical pathwayi | CFD (DF) (PFD) | 27033
Q9UNS1 | 2 | Protein timeless homolog ([NAME]) | 1208 | Nucleus. | FUNCTION: Required for normal progression of S-phase.nvolved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation.nvolved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubulesi | TMELESS (TM) (TM1) (TMELESS1) | 138630
P09341 | 2 | Growth-regulated alpha protein (C-X-C motif chemokine 1) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) (GRO-alpha(1-73)) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)]i | 107 | Secreted. | FUNCTION: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion.n vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activityi | CXCL1 (GRO) ([NAME]) (GROA) (MGSA) (SCYB1) | 11301
P02042 | 2 | Hemoglobin subunit delta (Hemoglobin delta chain) (Delta-globin) | 147 | i | FUNCTION: Involved in oxygen transport from the lung to the various peripheral tissues.i | HBD | 16055
Q5T848 | 2 | Probable G-protein coupled receptor 158i | 1215 | Cell membrane; Multi-pass membrane protein. | FUNCTION: Orphan receptori | GPR158 (KAA1136) | 135489
[NAME] | 2 | Nicotinic acetylcholine alpha-7 subuniti | 502 | Membrane; Multi-pass membrane protein. | i | CHRNA7 | 56504
Q59E99 | 2 | Thrombospondin 1 variant (Fragment) | 1225 | 134849
O60565 | 2 | Gremlin-1 (Cysteine knot superfamily 1, BMP antagonist 1) (Increased in high glucose protein 2) (IHG-2) (Down-regulated in Mos-transformed cells protein) (DAN domain family member 2) (Cell proliferation-inducing gene 2 protein) | 184 | Secreted. | FUNCTION: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity) | GREM1 (CKTSF1B1) (DAND2) (DRM) (PG2) | 20697
P50281 | 2 | Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) ([NAME]) (MT1MMP) (MMP-X1) | 582 | Membrane; Single-pass type I membrane protein. Melanosome. | FUNCTION: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surfacei | MMP14 | 65884
Q66K79 | 2 | Carboxypeptidase Z (CPZ) (EC 3.4.17.-) | 652 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processingi | CPZ | 73627
Q9NP99 | 2 | Triggering receptor expressed on myeloid cells 1 (Triggering receptor expressed on monocytes 1) (TREM-1) | 234 | Cell membrane; Single-pass type I membrane protein.  Secreted. | FUNCTION: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic [NAME] | TREM1 | 26387
Q2M1N2 | 2 | Laminin, gamma 2i | 1111 | i | i | LAMC2 | 121634
Q4V9L6 | 2 | [NAME] protein 119i | 283 | Membrane; Single-pass type I membrane protein. | i | TMEM119 (PSEC0199) (UNQ731/PRO1415) | 29203
Q9NQ84 | 2 | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | 441 | Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. | FUNCTION: Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways (By similarity).i | GPRC5C (RAG3) (PSEC0087) | 48193
Q9NP84 | 2 | Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266) | 129 | Membrane; Single-pass type I membrane protein. | FUNCTION: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteinsi | TNFRSF12A (FN14) | 13911
P22352 | 2 | Glutathione peroxidase 3 (EC 1.11.1.9) (GSHPx-3) (GPx-3) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GSHPx-P) (GPx-P) | 226 | Secreted. | FUNCTION: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathionei | GPX3 (GPXP) | 25552
Q59EE7 | 2 | Pro-alpha-1 type V collagen variant (Fragment) | 1792 | 178517
P58499 | 2 | Protein FAM3B (Cytokine-like protein 2-21) | 235 | Secreted. | FUNCTION: Has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner (By similarity) | FAM3B (C21orf11) (PRED44) (UNQ320/PRO365) | 25982
[NAME] | 2 | C-X-C motif chemokine 11 (Small-inducible cytokine B11) (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Interferon-gamma-inducible protein 9) (IP-9) (H174) (Beta-R1) | 94 | Secreted. | FUNCTION: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes.nduces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responsesi | CXCL11 (TAC) (SCYB11) (SCYB9B) | 10365
Q53G57 | 2 | [NAME] antigen 6 complex, locus E variant (Fragment) | 131 | 13477
P49788 | 2 | Retinoic acid receptor responder protein 1 (RAR-responsive protein TIG1) (Tazarotene-induced gene 1 protein) | 294 | Membrane; Single-pass type II membrane protein. | i | RARRES1 (TG1) | 33285
P00352 | 2 | Retinal dehydrogenase 1 (RALDH 1) (RalDH1) (EC 1.2.1.36) ([NAME] dehydrogenase family 1 member [NAME]) ([NAME] dehydrogenase, cytosolic) (ALHDII) (ALDH-E1) | 501 | Cytoplasm. | FUNCTION: Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).i | ALDH1A1 (ALDC) (ALDH1) (PUMB1) | 54862
Q67BC3 | 2 | Endogenous granzyme Bi | 281 | 31392
P68871 | 2 | Hemoglobin subunit beta ([NAME] beta chain) (Beta-globin) [Cleaved into: LVV-hemorphin-7]i | 147 | i | FUNCTION: Involved in oxygen transport from the lung to the various peripheral tissues.CC    FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.i | HBB | 15998
P02778 | 2 | C-X-C motif chemokine 10 (Small-inducible cytokine B10) (10 kDa interferon-gamma-induced protein) (Gamma-IP10) (IP-10) [Cleaved into: CXCL10(1-73)]i | 98 | Secreted. | FUNCTION: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.i | CXCL10 (NP10) (SCYB10) | 10881
Q08397 | 2 | Lysyl oxidase homolog 1 (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL) | 574 | Secreted â€º extracellular space. | FUNCTION: Active on elastin and collagen substrates (By similarity) | LOXL1 (LOXL) | 63110
Q08629 | 2 | Testican-1 (Protein SPOCK) | 439 | Secreted â€º extracellular space â€º extracellular matrix. | FUNCTION: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.i | SPOCK1 (SPOCK) (TC1) (TCN1) | 49124
Q13093 | 2 | Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (PAF 2-acylhydrolase) (LDL-associated phospholipase A2) (LDL-PLA(2)) (2-acetyl-1-alkylglycerophosphocholine esterase) (1-alkyl-2-acetylglycerophosphocholine esterase) | 441 | Secreted â€º extracellular space. | FUNCTION: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position.t is inactive against long-chain phospholipidsi | PLA2G7 (PAFAH) | 50077
Q6ZMB0 | 2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (Beta-1,3-N-acetylglucosaminyltransferase-6) (Beta3Gn-T6) (BGnT-6) (EC 2.4.1.-) (Core 3 synthase) | 384 | Golgi apparatus membrane; Single-pass type II membrane protein. | FUNCTION: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organsi | B3GNT6 | 42748