Spreadsheet: 3df9f365-3035-4af3-9fda-9af4da357896
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Table S6: Human orthologs and functional classification of confirmed dEGFRλ;dp110CAAX modifier kinases | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7
Table legend: Orthologs were curated from http://kinase.com/ and names for each were updated according to current Gene ID numbers and NCBI annotations.  GO terms from GOEast, http://omicslab.genetics.ac.cn/GOEAST/.
[NAME] name | CG number | [NAME] family | human orthologs | dEGFRλ; dp110CAAX | annotation by Flybase,       literature searches | KEGG ortholog, cancer involved | Selected GO enriched terms
For | CG10033 | AGC:PKG | PRKG1 , PRKG2 | SS | other signaling pathway |  | GO:0019538: protein metabolic process
[NAME] | CG10079 | TK:EGFR | EGFR, ERBB2, ERBB3, ERBB4 | SS | core RTK, cell cycle/growth control, apoptosis, cell migration/shape change | yes | GO:0030154: cellular differentiation, GO:0007049: cell cycle,                   GO:0019538: protein metabolic process,  GO:0007399: nervous system development
S6K | CG10539 | AGC:RSK:RSK | [NAME], RPS6KB2 | SS | core PI3K, cell cycle/growth, translation, metabolism |  | GO:0008361: regulation of cell size, GO:0030154: cellular differentiation, GO:0019538: protein metabolic process, GO:0007399: nervous system development
Cdk8 | CG10572 | CMGC:CDK | CDK8 | WS | transcription, other signaling pathway | yes | GO:0030154: cellular differentiation, GO:0007049: cell cycle,                   GO:0019538: protein metabolic process, GO:0007399: nervous system development
Eip63E | CG10579 | CMGC:CDK:PFTAIRE | PFTK1, PFTK2 | S | cell migration/shape change |  | GO:0019538: protein metabolic process
Madm | CG1098 | Other:NRBP | NRBP1, NRBP2 | S | unknown, cell cycle/growth control |  | GO:0008361: regulation of cell size, GO:0019538: protein metabolic process
CG11221 | CG11221 | Other:[NAME] | [NAME], [NAME], NUAK1 | S | unknown, cell cycle | yes | GO:0019538: protein metabolic process
Hippo | CG11228 | STE:STE20:MST | [NAME], MST2 | E | other signaling pathway, cell cycle/growth control | yes
CG11660 | CG11660 | Atypical:RIO:RIO1 | RIOK1 | SS | unknown, cell cycle/growth control, translational control
CG11859 | CG11859 | Atypical:RIO:RIO2 | RIOK2 | SS | translational control, cell cycle/growth control, unknown |  | GO:0019538: protein metabolic process
Warts | CG12072 | AGC:NDR | LATS1, [NAME] | E | other signaling pathway, cell cycle/growth control | yes
Rolled | CG12559 | CMGC:MAPK:ERK1 | [NAME], ERK2 | SS | core RTK pathway, cell cycle/growth control, cell migration/shape change | yes
Tkv | CG14026 | TKL:STKR:TypeI | ACVRL1, ACVR1, ACVR1B, ACVR1C, BMPR1A, BMPR1B, TGFBR1 | S | other signaling pathway, cell cycle/growth, apoptosis |  | GO:0008361: regulation of cell size, GO:0030154: cellular differentiation, GO:0019538: protein metabolic process
Tao-1 | CG14217 | STE:STE20:[NAME] | TAOK1, TAOK2, TAOK3 | E | cell cycle/growth control, cell migration/shape change |  | GO:0019538: protein metabolic process
Ack | CG14992 | TK:Ack | TNK1, TNK2 | S | cell cycle/growth, protein trafficking | yes | GO:0019538: protein metabolic process
Dsor | CG15793 | STE:STE7:MEK1 | MAP2K1, MAP2K2 | SS | core RTK pathway, cell cycle/growth control | yes
Taf1 | CG17603 | Atypical:TAF1 | TAF1, TAF1L | SS | transcription |  | GO:0016568: chromatin modification,  GO:0007049: cell cycle,                    GO:0019538: protein metabolic process
InR | CG18402 | TK:InsR | IGF1R,  INSR, INSRR | S | core RTK pathway, cell cycle/growth, metabolism, protein translation | yes | GO:0008361: regulation of cell size, GO:0030154: cellular differentiation, GO:0019538: protein metabolic process, GO:0007399: nervous system development
Sax | CG1891 | TKL:STKR:TypeI | ACVRL1, ACVR1, ACVR1B, ACVR1C, BMPR1A, BMPR1B, TGFBR1 | WS | other signaling pathway, cell cycle/growth, apoptosis |  | GO:0030154: cellular differentiation, GO:0019538: protein metabolic process, GO:0007399: nervous system development
CK1alpha | CG2028 | CK1:CK1 | CSNK1A1 | SS | other signaling pathway, cell cycle control
Phl/Raf | CG2845 | TKL:RAF:RAF | ARAF, BRAF, [NAME] | SS | core RTK pathway, cell cycle/growth control | yes | GO:0030154: cellular differentiation, GO:0019538: protein metabolic process, GO:0007399: nervous system development
Ksr | CG2899 | TKL:RAF:KSR | KSR1, [NAME] | SS | core RTK pathway, cell cycle/growth control |  | GO:0019538: protein metabolic process
Drak | CG32666 | DAPK:DRAK | STK17A/DRAK1, STK17B/DRAK2 | S | apoptosis, unknown, cell cycle/growth, cell migration/shape change |  | GO:0008360: regulation of cell shape, GO:0019538: protein metabolic process
Smg1 | CG32743 | PIKK:SMG1 | SMG1 | E | translation, unknown, transcription
Cdk7 | CG3319 | CMGC:CDK | CDK7 | SS | transcription, cell cycle |  | GO:0007049: cell cycle,                    GO:0019538: protein metabolic process
Nipped-A | CG33554 | PIKK:TRRAP | TRAPP | S | cell cycle, core PI3K, transcription | yes
[NAME] | CG34412 | Other:TLK | TLK1, TLK2 | SS | cell cycle |  | GO:0008360: regulation of cell shape, GO:0016568: chromatin modification,  GO:0007049: cell cycle,                    GO:0019538: protein metabolic process
Akt1 | CG4006 | AGC:[NAME] | AKT1, AKT2, AKT3 | SS | core PI3K, cell cycle/growth, metabolism, translation, cell migration/cell shape change | yes | GO:0008360: regulation of cell shape, GO:0008361: regulation of cell size, GO:0030154: cellular differentiation, GO:0019538: protein metabolic process, GO:0007399: nervous system development
dp110 (PI3K92E) | CG4141 | PI3K class I | PIK3CA (p110alpha), [NAME] (p110beta), PIK3CD (p110delta), [NAME] (p110gamma) | SS | core PI3K, cell cycle/growth, metabolism, translation, cell migration/cell shape change | yes | GO:0008361: regulation of cell size, GO:0007399: nervous system development, GO:0030154: cellular differentiation,
CG42366 | CG42366 | RCK:MAK | MAK | SS | unknown, cell migration |  | GO:0019538: protein metabolic process
Pitslre | CG4268 | CMGC:CDK | CDK11B, CDK11A | E | cell cycle/growth, cell migration/shape change |  | GO:0008360: regulation of cell shape, GO:0007049: cell cycle,                   GO:0019538: protein metabolic process
Cdk4 | CG5072 | CMGC:CDK | CDK4, [NAME] | WS | cell cycle/growth, metabolism, protein translation | yes | GO:0008361: regulation of cell size, GO:0007049: cell cycle,                                        GO:0019538: protein metabolic process
Tor | CG5092 | PIKK:FRAP | MTOR | SS | core PI3K, cell cycle/growth, metabolism, protein translation |  | GO:0008361: regulation of cell size, GO:0030154: cellular differentiation, GO:0019538: protein metabolic process, GO:0007399: nervous system development
Cdk9 | CG5179 | CMGC:CDK | [NAME] | SS | transcription |  | GO:0008360: regulation of cell shape, GO:0007049: cell cycle,                   GO:0019538: protein metabolic process
Cdc2 | CG5363 | CMGC:CDK:CDK1 | [NAME] | S | cell cycle |  | GO:0030154: cellular differentiation, GO:0007049: cell cycle,                   GO:0019538: protein metabolic process, GO:0007399: nervous system development
JIL-1 | CG6297 | AGC:RSK:MSK | RPS6KA5, RPS6KA4 | WS | transcription |  | GO:0016568: chromatin modification,  GO:0007049: cell cycle,                    GO:0019538: protein metabolic process
CG6498 | CG6498 | MAST | MAST1, MAST2, MAST4, MAST3 | E | cell cycle/growth control, unknown |  | GO:0019538: protein metabolic process
ial (auroraB) | CG6620 | Other:Aur | AURKB | S | cell cycle |  | GO:0016568: chromatin modification,  GO:0007049: cell cycle,                   GO:0019538: protein metabolic process
Cdk12 | CG7597 | CDK:CRK7 | CDK12 | SS | cell cycle/cell growth |  | GO:0019538: protein metabolic process
Fray | CG7693 | STE:STE20:FRAY | STL39/SPAK, OXSR1 | S | ion homeostasis |  | GO:0030154: cellular differentiation, GO:0019538: protein metabolic process, GO:0007399: nervous system development
[NAME] | CG7826 | CMGC:DYRK:DYRK1 | DYRK1A, DYRK1B | WS | cell cycle |  | GO:0019538: protein metabolic process, GO:0007399: nervous system development
Src42A | CG7873 | TK:Src | SRC, YES, FYN, LYN, HCK, LCK | SS | core RTK, cell cycle/growth, cell migration/shape change | yes | GO:0019538: protein metabolic process
Punt | CG7904 |  | ACVR2A, ACVR2B, BMPR2, AMHR2, [NAME] | S | other signaling pathway, cell cycle/growth, apoptosis
[NAME] | CG8222 | TK:VEGFR | PDGFRalpha, PDGFRbeta, KDR, FLT4, FLT1 | S | core RTK, cell cycle/growth, cell migration/shape change | yes | GO:0008360: regulation of cell shape, GO:0030154: cellular differentiation, GO:0007049: cell cycle,                   GO:0019538: protein metabolic process, GO:0007399: nervous system development
CG8878 | CG8878 | CK1:VRK: | VRK1, VRK2 | SS | unknown, cell cycle/growth |  | GO:0019538: protein metabolic process