Spreadsheet: 28551d8c-073a-4aed-a06d-8c5f130d0061
Sheet: Sheet1

Table S5. Hippocampal probe sets with involvement in neuronal regeneration and concordantly increased expression (One-way ANOVA, p-values based on F-distribution) in captopril-treated 18 month-old Tg2576 (Tg-18mo-ACEI) and 12 month-old Tg2576 (Tg-12mo) mice relative to 18 month-old Tg2576 mice (Tg-18mo). | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12
Affymetrix-ID | Descriptions | Mean Tg-18mo | Mean Tg-18mo-ACEI | Mean Tg-12mo | ANOVA (p value based on F-distribution) | Tg-18mo-1 | Tg-18mo-2 | Tg-18mo-ACEI-1 | Tg-18mo-ACEI-2 | Tg-12mo-1 | Tg-12mo-2 | Gene name
1422748_at | [NAME]:NM_015753.1 /DB_XREF=gi:7657694 /GEN=Zfhx1b /FEA=FLmRNA /CNT=37 /TID=Mm.37676.1 /TIER=FL+Stack /STK=15 /UG=Mm.37676 /LL=24136 /DEF=Mus musculus zinc finger homeobox 1b (Zfhx1b), mRNA. /PROD=zinc finger homeobox 1b /FL=gb:NM_015753.1 gb:AF033116.1 | 1514.15 | 5427.6 | 3174.9 | 0.000245993 | 1407.8 | 1620.5 | 5565.6 | 5289.6 | 3182.5 | 3167.3 | Zfhx1b
1427542_at | gb:BC027318.1 /DB_XREF=gi:20071233 /FEA=mRNA /CNT=5 /TID=Mm.153750.1 /TIER=[NAME] /STK=0 /UG=Mm.153750 /UG_TITLE=Mus musculus, clone IMAGE:3980989, mRNA /DEF=Mus musculus, clone IMAGE:3980989, mRNA. | 506.05 | 1508.25 | 1127.55 | 0.003338117 | 508.1 | 504 | 1607.9 | 1408.6 | 1085.6 | 1169.5 | Sobp
1431804_a_at | gb:AK004607.1 /DB_XREF=gi:12835892 /FEA=mRNA /CNT=1 /TID=Mm.28513.2 /TIER=[NAME] /STK=0 /UG=Mm.28513 /LL=20687 /UG_GENE=Sp3 /UG_TITLE=trans-acting transcription factor 3 /DEF=Mus musculus adult male lung cDNA, RIKEN full-length enriched library, clone:1200006A08:trans-acting transcription factor 3, full insert sequence. | 522.7 | 1307 | 1139.5 | 0.0003752941 | 543.5 | 501.9 | 1298.2 | 1315.8 | 1103.8 | 1175.2 | Sp3
1437801_at | [NAME]:BM115860 /DB_XREF=gi:17078878 /DB_XREF=L0826E05-3 /CLONE=L0826E05 /FEA=EST [NAME] /TID=Mm.196508.8 /TIER=Stack /STK=14 /UG=Mm.196508 /LL=21761 /UG_GENE=Tex189 /UG_TITLE=testis expressed gene 189 | 1886.05 | 3770.65 | 6523.3 | 0.0013871186 | 1744.7 | 2027.4 | 3836.4 | 3704.9 | 6187.6 | 6859 | Morf4l1
1418141_at | [NAME]:BM115908 /DB_XREF=gi:17078926 /DB_XREF=L0827D09-3 /CLONE=L0827D09 /FEA=FLmRNA /CNT=90 /TID=Mm.12871.1 /TIER=Stack /STK=10 /UG=Mm.12871 /LL=13193 /UG_GENE=Dcx /UG_TITLE=doublecortin /FL=gb:AB011678.1 gb:AF045547.1 [NAME]:NM_010025.1 | 186.2 | 431.95 | 402.6 | 0.00025027653 | 192.5 | 179.9 | 435.9 | 428 | 393.2 | 412 | Dcx
1418431_at | [NAME]:BI328541 /DB_XREF=gi:15013198 /DB_XREF=602985332F1 /CLONE=IMAGE:5138167 /FEA=FLmRNA /CNT=397 /TID=Mm.3380.1 /TIER=Stack /STK=11 /UG=Mm.3380 /LL=16573 /UG_GENE=Kif5b /UG_TITLE=kinesin family member 5B /FL=gb:NM_008448.1 [NAME]:U86090.1 | 441.05 | 1974.55 | 1309.55 | 0.00014392672 | 456.1 | 426 | 1990.3 | 1958.8 | 1256.8 | 1362.3 | Kif5b
1419038_a_at | [NAME]:BB283759 /DB_XREF=gi:8984208 /DB_XREF=BB283759 /CLONE=A930103E12 /FEA=FLmRNA /CNT=162 /TID=Mm.23692.1 /TIER=Stack /STK=8 /UG=[NAME] /LL=12999 /UG_GENE=Csnk2a1-rs4 /UG_TITLE=casein kinase II, alpha 1 related sequence 4 /FL=gb:NM_007788.1 gb:U51866.1 gb:BC026149.1 | 870.4 | 3762.2 | 2290.2998 | 9.544039e-05 | 879.9 | 860.9 | 3689.9 | 3834.5 | 2348.9 | 2231.7 | Csnk2a1
1422553_at | [NAME]:NM_008960.1 /DB_XREF=gi:6679522 /GEN=Pten /FEA=FLmRNA /CNT=146 /TID[NAME] /TIER=FL+Stack /STK=37 /UG=Mm.1591 /LL=19211 /DEF=Mus musculus phosphatase and tensin homolog ([NAME]), mRNA. /PROD=phosphatase and tensin homolog /FL=gb:[NAME]:NM_008960.1 gb:U92437.1 | 1013.19995 | 3845.15 | 2828.25 | 5.855101e-06 | 1044.6 | 981.8 | 3845.4 | 3844.9 | 2809.5 | 2847 | Pten
1425533_a_at | [NAME]:BC025118.1 /DB_XREF=gi:19264082 /FEA=FLmRNA /CNT=45 /TID=Mm.41481.2 /TIER=FL /STK=1 /UG=Mm.41481 /LL=29819 /UG_GENE=Stau2 /DEF=Mus musculus, Similar to staufen, RNA binding protein, homolog 2 (Drosophila), clone MGC:36821 IMAGE:3670067, mRNA, complete cds. /PROD=Similar to staufen, RNA binding protein, homolog2 (Drosophila) /FL=gb:BC025118.1 | 1341.95 | 4204.4 | 2824.05 | 2.5719013e-05 | 1332.8 | 1351.1 | 4262.3 | 4146.5 | 2812.3 | 2835.8 | Stau2
1425597_a_at | [NAME]:AW060288 /DB_XREF=gi:6008004 /DB_XREF=UI-M-BH1-amv-b-05-0-UI.s1 /CLONE=UI-M-BH1-amv-b-05-0-UI /FEA=FLmRNA /CNT=22 /TID=Mm.2655.3 /TIER=Stack /STK=10 /UG=Mm.2655 /LL=19317 /UG_GENE=qk /UG_TITLE=quaking /FL=gb:U44940.1 | 281.05 | 1283.7 | 782.05 | 0.0008280794 | 249.7 | 312.4 | 1232.1 | 1335.3 | 810.8 | 753.3 | Qk
1426114_at | [NAME]:L36663.1 /DB_XREF=gi:840647 /FEA=FLmRNA /CNT=1 /TID=MmAffx.1.19 /TIER=FL /STK=1 /NOTE=sequence(s) not in UniGene /DEF=Mus musculus CArG box-binding factor mRNA, complete cds. /PROD=CArG box-binding factor /FL=gb:L36663.1 | 2549.9502 | 5837.95 | 11374.551 | 4.4026156e-06 | 2559.6 | 2540.3 | 5801.2 | 5874.7 | 11278.4 | 11470.7 | Hnrnpab
1426777_a_at | [NAME]:BF466143 /DB_XREF=gi:11535326 /DB_XREF=UI-M-CG0p-bqu-a-07-0-UI.s1 /CLONE=UI-M-CG0p-bqu-a-07-0-UI /FEA=mRNA /CNT=165 /TID=Mm.1574.1 /TIER=Stack /STK=30 /UG=Mm.1574 /LL=73178 /UG_GENE=Wasl /UG_TITLE=Wiskott-Aldrich syndrome-like (human) | 726.2 | 3073.65 | 1456.25 | 2.2847646e-05 | 713.4 | 739 | 3100.8 | 3046.5 | 1494 | 1418.5 | Wasl
1435520_at | [NAME]:BB418489 /DB_XREF=gi:16423415 /DB_XREF=BB418489 /CLONE=C530010I15 /FEA=EST /CNT=101 /TID=Mm.35930.1 /TIER=Stack /STK=15 /UG=Mm.35930 /LL=103787 /UG_GENE=AI563628 /UG_TITLE=expressed sequence AI563628 | 277.7 | 708.75 | 618.05 | 0.0022841508 | 288.6 | 266.8 | 749.2 | 668.3 | 626.3 | 609.8 | Msi2
1435521_at | [NAME]:BQ174527 /DB_XREF=gi:20350018 /DB_XREF=UI-M-DJ2-bvy-k-08-0-UI.s1 /CLONE=UI-M-DJ2-bvy-k-08-0-UI /FEA=EST /CNT=101 /TID=Mm.35930.1 /TIER=Stack /STK=60 /UG=Mm.35930 /LL=103787 /UG_GENE=AI563628 /UG_TITLE=expressed sequence AI563628 | 156.7 | 716.30005 | 987.10004 | 0.0005030066 | 148.7 | 164.7 | 745.2 | 687.4 | 1024.3 | 949.9 | Msi2
1436746_at | [NAME]:BI692255 /DB_XREF=gi:15654884 /DB_XREF=603342721F1 /CLONE=IMAGE:5370700 /FEA=EST /CNT=96 /TID=Mm.27341.1 /TIER=Stack /STK=69 /UG=Mm.27341 /UG_TITLE=ESTs, Moderately similar to protein kinase, lysine deficient 1 (Rattus norvegicus) (R.norvegicus) | 533.65 | 3708.7 | 1136.05 | 1.13442065e-05 | 583 | 484.3 | 3688.2 | 3729.2 | 1131.9 | 1140.2 | Wnk1
1436850_at | [NAME]:AV338277 /DB_XREF=gi:16396655 /DB_XREF=AV338277 /CLONE=6430408F09 /FEA=EST [NAME] /TID=Mm.122091.1 /TIER=Stack /STK=43 /UG=Mm.122091 /UG_TITLE=ESTs, Weakly similar to cellular repressor of E1A-stimulated genes (Mus musculus) (M.musculus) | 100.600006 | 954.9 | 383.90002 | 0.0014933811 | 101.3 | 99.9 | 1023.8 | 886 | 400.2 | 367.6 | Creg2
1437107_at | [NAME] /CLONE=C330006L04 /FEA=EST /CNT=110 /TID=Mm.193647.1 /TIER=Stack /STK=13 /UG=Mm.193647 /LL=52848 /UG_GENE=D9Bwg0185e /UG_TITLE=DNA segment, Chr 9, Brigham & Womens Genetics 0185 expressed | 371.45 | 2670 | 776.05 | 1.5795482e-06 | 382.1 | 360.8 | 2674.6 | 2665.4 | 759.5 | 792.6 | Rab6b
1438039_at | [NAME]gi:9913287 /DB_XREF=uu38b09.x1 /CLONE=IMAGE:3374201 /FEA=EST /CNT=21 /TID=Mm.36670.1 /TIER=Stack /STK=12 /UG=Mm.36670 /LL=104890 /UG_GENE=AI844876 /UG_TITLE=expressed sequence AI844876 | 546.30005 | 2026.35 | 1103.6499 | 9.389724e-05 | 561.7 | 530.9 | 2029.6 | 2023.1 | 1058.2 | 1149.1 | Hectd1
1447763_at | [NAME]:AV160090 /DB_XREF=gi:5403725 /DB_XREF=AV160090 /CLONE=3010040M24 /FEA=EST /CNT=2 /TID=Mm.45283.1 /TIER=[NAME] /STK=2 /UG=Mm.45283 /UG_TITLE=ESTs | 468.15 | 1113.6 | 2184.4 | 0.00017782042 | 473.9 | 462.4 | 1107.1 | 1120.1 | 2252.9 | 2115.9 | Snap25
1448885_at | [NAME]:BB645629 /DB_XREF=gi:15402342 /DB_XREF=BB645629 /CLONE=[NAME] /FEA=FLmRNA /CNT=101 /TID=Mm.26939.1 /TIER=Stack /STK=25 /UG=[NAME]=Rap2b /UG_TITLE=RAP2B, member of RAS oncogene family /FL=gb:NM_028712.1 | 639.19995 | 1823.4 | 1576.9 | 0.00038912115 | 587.6 | 690.8 | 1829 | 1817.8 | 1615.5 | 1538.3 | Rap2b
1449961_at | [NAME] /DB_XREF=gi:16945961 /GEN=Rph3a /FEA=FLmRNA /CNT=11 /TID=Mm.181166.1 /TIER=FL /STK=3 /UG=Mm.181166 /LL=19894 /DEF=Mus musculus rabphilin 3A (Rph3a), mRNA. /PROD=rabphilin 3A /FL=gb:D29965.1 gb:NM_011286.1 | 407.3 | 1520.3 | 912.4 | 5.403592e-06 | 400.1 | 414.5 | 1532.1 | 1508.5 | 911.9 | 912.9 | Rph3a
1450368_a_at | [NAME] /DB_XREF=[NAME] /GEN=Ppp3r1 /FEA=FLmRNA /CNT=2 /TID=Mm.41840.1 /TIER=FL /STK=2 /UG=Mm.41840 /LL=19058 /DEF=Mus musculus protein phospatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) (Ppp3r1), mRNA. /PROD=protein phospatase 3, regulatory subunit B,alpha isoform (calcineurin B, type I) /FL=gb:[NAME]:BC002267.1 | 199.6 | 473.2 | 408.75 | 0.0029161102 | 210.8 | 188.4 | 493.5 | 452.9 | 426.5 | 391 | Cnb1
1452722_a_at | [NAME]:BB702110 /DB_XREF=gi:16050934 /DB_XREF=BB702110 /CLONE=7420437M16 /FEA=mRNA /CNT=238 /TID=Mm.46579.1 /TIER=Stack /STK=62 /UG=[NAME] /LL=75717 /UG_GENE=4921514I20Rik /UG_TITLE=RIKEN cDNA 4921514I20 gene | 147.5 | 705.5 | 430.65 | 0.00017530604 | 168.8 | 126.2 | 709.1 | 701.9 | 425.9 | 435.4 | Cul5
1456088_at | [NAME] /DB_XREF=gi:10973240 /DB_XREF=601778893F1 /CLONE=IMAGE:4007134 /FEA=EST [NAME] /TID=Mm.149115.6 /TIER=Stack /STK=16 /UG=Mm.149115 /LL=11798 /UG_GENE=Birc4 /UG_TITLE=baculoviral IAP repeat-containing 4 | 188.8 | 632.4 | 427.1 | 9.1969625e-05 | 186.1 | 191.5 | 640.4 | 624.4 | 438.5 | 415.7 | Xiap
1456656_at | [NAME] /DB_XREF=gi:5492611 /DB_XREF=UI-M-AH1-agv-h-06-0-UI.s1 /CLONE=UI-M-AH1-agv-h-06-0-UI /FEA=EST /CNT=10 /TID=Mm.40698.1 /TIER=Stack /STK=8 /UG=Mm.40698 /LL=103301 /UG_GENE=AI848705 /UG_TITLE=expressed sequence AI848705 | 208.85 | 827.5 | 537 | 0.0002931135 | 225 | 192.7 | 844.4 | 810.6 | 519.6 | 554.4 | Veli1
1456911_at | gb:BB831639 /DB_XREF=gi:17009882 /DB_XREF=BB831639 /CLONE=G930018E16 /FEA=EST /CNT=8 /TID=Mm.214961.1 /TIER=[NAME] /STK=6 /UG=Mm.214961 /UG_TITLE=ESTs, Weakly similar to T00386 hypothetical protein KIAA0627 (H.sapiens) | 66.7 | 245.95 | 170.79999 | 0.002083384 | 72 | 61.4 | 232.6 | 259.3 | 162.9 | 178.7 | Clasp2
1418230_a_at | [NAME]:BC005621.1 /DB_XREF=gi:13542843 /FEA=FLmRNA /CNT=178 /TID=Mm.29097.1 /TIER=FL+Stack /STK=27 /UG=Mm.29097 /LL=110829 /UG_GENE=Lims1l /DEF=Mus musculus, RIKEN cDNA 4921524A02 gene, clone MGC:11585 IMAGE:3711611, mRNA, complete cds. /PROD=RIKEN cDNA 4921524A02 gene /FL=gb:NM_026148.1 gb:BC005621.1 | 153.95 | 409.85 | 322.95 | 0.00066901406 | 162.9 | 145 | 396.5 | 423.2 | 324.6 | 321.3 | Lims1l
1420402_at | [NAME]:NM_009723.1 /DB_XREF=gi:6753139 /GEN=Atp2b2 /FEA=FLmRNA /CNT=26 /TID=Mm.20441.1 /TIER=FL /STK=5 /UG=Mm.20441 /LL=11941 /DEF=Mus musculus ATPase, Ca++ transporting, plasma membrane 2 (Atp2b2), mRNA. /PROD=ATPase, Ca++ transporting, plasma membrane 2 /FL=gb:AF053471.1 gb:NM_009723.1 gb:AB030738.1 gb:AB030737.1 | 517.8 | 2312.9 | 2565.7 | 3.6514186e-05 | 566.1 | 469.5 | 2329.9 | 2295.9 | 2576.9 | 2554.5 | Atp2b2
1421929_at | [NAME]:BB706548 /DB_XREF=gi:16055383 /DB_XREF=BB706548 /CLONE=7420491D14 /FEA=FLmRNA /CNT=39 /TID=Mm.3249.1 /TIER=Stack /STK=18 /UG=Mm.3249 /LL=13838 /UG_GENE=Epha4 /UG_TITLE=Eph receptor A4 /FL=gb:NM_007936.1 gb:BC004782.1 | 413 | 2338.75 | 955.9 | 0.00056282716 | 426.9 | 399.1 | 2448.4 | 2229.1 | 919.6 | 992.2 | Epha4
1422834_at | [NAME]:NM_019697.1 /DB_XREF=gi:9790092 /GEN=Kcnd2 /FEA=FLmRNA /CNT=51 /TID=Mm.132309.1 /TIER=FL+Stack /STK=10 /UG=Mm.132309 /LL=16508 /DEF=Mus musculus potassium voltage-gated channel, Shal-related family, member 2 ([NAME]), mRNA. /PROD=potassium voltage-gated channel, Shal-relatedfamily, member 2 /FL=gb:AF107780.1 gb:NM_019697.1 | 584.95 | 2094.85 | 1264.75 | 1.4734671e-06 | 587.9 | 582 | 2092.4 | 2097.3 | 1253.2 | 1276.3 | Kcnd2
1423559_at | [NAME]:BB750192 /DB_XREF=gi:16154428 /DB_XREF=BB750192 /CLONE=[NAME] /FEA=FLmRNA [NAME] /TID=Mm.1926.1 /TIER=Stack /STK=11 /UG=[NAME]=Kcnc1 /UG_TITLE=potassium voltage gated channel, Shaw-related subfamily, member 1 /FL=gb:NM_008421.1 | 696.9 | 2099.05 | 999.35 | 0.00024658808 | 649.9 | 743.9 | 2054.3 | 2143.8 | 990 | 1008.7 | Kcnc1
1423597_at | [NAME]:BB303874 /DB_XREF=gi:15411244 /DB_XREF=BB303874 /CLONE=B230107D19 /FEA=FLmRNA /CNT=81 /TID=Mm.33083.1 /TIER=Stack /STK=9 /UG=Mm.33083 /LL=11980 /UG_GENE=Atp8a1 /UG_TITLE=ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 /FL=gb:[NAME]:U75321.1 | 1472.45 | 6920.6 | 3048.4 | 6.9124153e-06 | 1489 | 1455.9 | 6994.1 | 6847.1 | 3053.9 | 3042.9 | Atp3a2
1439940_at | [NAME] /DB_XREF=gi:15406324 /DB_XREF=AV328280 /CLONE=6330440N14 /FEA=EST /CNT=7 /TID=Mm.44658.1 /TIER=[NAME] /STK=6 /UG=Mm.44658 /UG_TITLE=ESTs | 2005.15 | 6287.55 | 5778.5996 | 0.0006239059 | 2151.6 | 1858.7 | 6186.9 | 6388.2 | 5557.4 | 5999.8 | Slc1a2
1441728_at | [NAME]:BI731739 /DB_XREF=gi:15708752 /DB_XREF=603353512F1 /CLONE=IMAGE:5361050 /FEA=EST /CNT=4 /TID=Mm.206118.1 /TIER=[NAME] /STK=4 /UG=Mm.206118 /UG_TITLE=ESTs, Moderately similar to voltage gated Na channel Scn8a (M.musculus) | 79.100006 | 526.44995 | 316.75 | 2.126656e-05 | 82.3 | 75.9 | 523.1 | 529.8 | 309.3 | 324.2 | Scn1a
1450120_at | [NAME]:NM_018733.1 /DB_XREF=[NAME] /GEN=Scn1a /FEA=FLmRNA /CNT=29 /TID=Mm.142733.1 /TIER=FL /STK=2 /UG=Mm.142733 /LL=20265 /DEF=Mus musculus sodium channel, voltage-gated, type I, alpha polypeptide (Scn1a), mRNA. /PROD=sodium channel, voltage-gated, type I, alphapolypeptide /FL=gb:NM_018733.1 gb:L42339.1 | 217.4 | 1309.6 | 544.25 | 0.00031715346 | 211.9 | 222.9 | 1265.6 | 1353.6 | 513.1 | 575.4 | Scn1a
1452089_at | [NAME]:AW106929 /DB_XREF=gi:6077729 /DB_XREF=um34d04.x1 /CLONE=IMAGE:2236423 /FEA=FLmRNA /CNT=79 /TID=Mm.28404.1 /TIER=Stack /STK=71 /UG=Mm.28404 /UG_TITLE=Mus musculus, clone MGC:31529 IMAGE:4501980, mRNA, complete cds /FL=gb:[NAME] | 891.75 | 2582.7002 | 2049.4502 | 0.00015816085 | 918.1 | 865.4 | 2531.8 | 2633.6 | 2016.3 | 2082.6 | Cacnb4
1456119_at | [NAME]:AV334671 /DB_XREF=gi:16396307 /DB_XREF=AV334671 /CLONE=6330563B19 /FEA=EST /CNT=30 /TID=Mm.101058.1 /TIER=Stack /STK=15 /UG=Mm.101058 /LL=101677 /UG_GENE=AI850523 /UG_TITLE=expressed sequence AI850523 | 1043.2 | 2978.85 | 2713 | 0.00020250898 | 1065.5 | 1020.9 | 3023.2 | 2934.5 | 2784.8 | 2641.2 | Grm5
1456863_at | [NAME]:AI385584 /DB_XREF=gi:4199047 /DB_XREF=mb18d08.x1 /CLONE=IMAGE:329775 /FEA=EST /CNT=7 /TID=Mm.200233.1 /TIER=[NAME] /UG=Mm.200233 /LL=98323 /UG_GENE=AI385584 /UG_TITLE=expressed sequence AI385584 | 97.7 | 840.75 | 305.15 | 0.0011435286 | 98.7 | 96.7 | 897 | 784.5 | 314.4 | 295.9 | Epha4