Spreadsheet: a821f92a-da4d-4b65-96a6-8b74d420d6e7
Sheet: Sheet1

Table S9. Conservation scores of catalytic, allosteric, and surface residues of ATCase, GPb, and FBPase calculated by using ortholog sequences | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5
Conservation scores of catalytic, allosteric, and surface residues of ATCase
PDB | Chain | Type | Residue | Conservation Score | Surface Area (Å2)
2FZC | A | Catalytic Site | E50 | 0.907 | 57.73
 |  |  | A51 | 0.571 | 51.54
 |  |  | S52 | 1 | 17.37
 |  |  | T53 | 0.949 | 84.29
 |  |  | R54 | 0.988 | 131
 |  |  | T55 | 0.994 | 14.75
 |  |  | R105 | 0.988 | 28.81
 |  |  | A127 | 0.823 | 0
 |  |  | H134 | 0.988 | 8.61
 |  |  | Q137 | 0.988 | 17.28
 |  |  | R167 | 0.988 | 39.11
 |  |  | T168 | 0.868 | 14.87
 |  |  | R229 | 0.988 | 95.77
 |  |  | P266 | 0.946 | 32.22
 |  |  | L267 | 0.859 | 26.76
 |  |  | P268 | 0.946 | 61.16
2FZC | B | [NAME] | T2 | 0.369 | 94.58
 |  |  | H3 | 0.198 | 21.76
 |  |  | E10 | 0.593 | 12.48
 |  |  | A11 | 0.645 | 33.72
 |  |  | I12 | 0.895 | 8.77
 |  |  | K13 | 0.231 | 73.67
 |  |  | V17 | 0.889 | 13.92
 |  |  | [NAME] | 0.987 | 28.15
 |  |  | H20 | 0.994 | 66.21
 |  |  | [NAME] | 0.356 | 111.27
 |  |  | K56 | 0.981 | 25.47
 |  |  | [NAME] | 0.777 | 9.28
 |  |  | K60 | 0.981 | 6.26
 |  |  | T82 | 0.829 | 13.14
 |  |  | N84 | 0.869 | 10.03
 |  |  | I86 | 0.744 | 11.89
 |  |  | N88 | 0.402 | 119.15
 |  |  | [NAME] | 0.435 | 120.04
 |  |  | E90 | 0.073 | 116.42
 |  |  | [NAME] | 0.783 | 61.3
 |  |  | K94 | 0.981 | 150.23
2FZC | A | Surface | A1 | 0.11 | 92.57
 |  |  | P3 | 0.071 | 94.21
 |  |  | Y5 | 0.1 | 74.56
 |  |  | Q6 | 0.281 | 70.07
 |  |  | K7 | 0.336 | 84.91
 |  |  | H8 | 0.63 | 61.53
 |  |  | N13 | 0.184 | 76.82
 |  |  | D14 | 0.413 | 76.58
 |  |  | S16 | 0.255 | 54.54
 |  |  | R17 | 0.194 | 79.17
 |  |  | D18 | 0.039 | 106.67
 |  |  | N21 | 0.039 | 54.73
 |  |  | K29 | 0.088 | 76.13
 |  |  | K31 | 0.381 | 77.49
 |  |  | A32 | 0.094 | 73.66
 |  |  | N33 | 0.165 | 102.08
 |  |  | P34 | 0.362 | 95.99
 |  |  | Q35 | 0.288 | 54.55
 |  |  | [NAME] | 0.22 | 80.17
 |  |  | E37 | 0.239 | 105.56
 |  |  | K40 | 0.175 | 109.5
 |  |  | H41 | 0.649 | 158.21
 |  |  | K42 | 0.397 | 65.12
 |  |  | V43 | 0.588 | 50.73
 |  |  | R56 | 0.736 | 57.23
 |  |  | L57 | 0.494 | 96.4
 |  |  | T61 | 0.475 | 50.69
 |  |  | H64 | 0.484 | 104.73
 |  |  | R65 | 0.723 | 153.1
 |  |  | S69 | 0.378 | 59.85
 |  |  | [NAME] | 0.481 | 77.03
 |  |  | G72 | 0.52 | 51.97
 |  |  | F73 | 0.526 | 51.9
 |  |  | D75 | 0.42 | 96
 |  |  | A77 | 0.217 | 89.06
 |  |  | N78 | 0.371 | 78.82
 |  |  | S80 | 0.9 | 62.17
 |  |  | L81 | 0.852 | 55.02
 |  |  | K83 | 0.31 | 118.32
 |  |  | K84 | 0.959 | 133.88
 |  |  | G85 | 0.904 | 57.66
 |  |  | E86 | 0.959 | 64.05
 |  |  | D90 | 0.917 | 71.38
 |  |  | V94 | 0.771 | 59.89
 |  |  | T97 | 0.675 | 110.27
 |  |  | [NAME] | 0.794 | 141.05
 |  |  | D100 | 0.778 | 51.41
 |  |  | P107 | 0.197 | 54.74
 |  |  | E117 | 0.075 | 71.11
 |  |  | F118 | 0.233 | 61.23
 |  |  | G120 | 0.062 | 63.98
 |  |  | N121 | 0.136 | 121.97
 |  |  | S131 | 0.368 | 54.92
 |  |  | E147 | 0.407 | 77.07
 |  |  | G150 | 0.352 | 63.12
 |  |  | R151 | 0.039 | 99.49
 |  |  | N154 | 0.4 | 88.96
 |  |  | H156 | 0.259 | 53.17
 |  |  | K164 | 0.433 | 81.86
 |  |  | Y165 | 0.826 | 87.92
 |  |  | D180 | 0.507 | 84.01
 |  |  | R183 | 0.117 | 86.28
 |  |  | D190 | 0.126 | 140.95
 |  |  | A191 | 0.584 | 52.25
 |  |  | Q196 | 0.046 | 111.27
 |  |  | [NAME] | 0.168 | 118.63
 |  |  | D200 | 0.055 | 73.88
 |  |  | D203 | 0.046 | 81.78
 |  |  | E204 | 0.078 | 154.41
 |  |  | K205 | 0.21 | 109.05
 |  |  | G206 | 0.091 | 67.71
 |  |  | A208 | 0.3 | 54.56
 |  |  | W209 | 0.081 | 69.89
 |  |  | L211 | 0.049 | 108.78
 |  |  | S213 | 0.159 | 80.32
 |  |  | E216 | 0.513 | 101.84
 |  |  | E217 | 0.365 | 100.62
 |  |  | A220 | 0.223 | 54.47
 |  |  | E221 | 0.207 | 71.18
 |  |  | K232 | 0.384 | 109.15
 |  |  | E233 | 0.959 | 123.88
 |  |  | R234 | 0.41 | 119.76
 |  |  | D236 | 0.71 | 76.46
 |  |  | P237 | 0.146 | 88.76
 |  |  | S238 | 0.236 | 71.56
 |  |  | E239 | 0.681 | 67.67
 |  |  | A241 | 0.268 | 60.06
 |  |  | N242 | 0.155 | 126.15
 |  |  | K244 | 0.359 | 95.73
 |  |  | A245 | 0.652 | 67.91
 |  |  | Q246 | 0.471 | 73.38
 |  |  | R250 | 0.43 | 118.81
 |  |  | S252 | 0.113 | 79.15
 |  |  | H255 | 0.052 | 141.68
 |  |  | N256 | 0.039 | 62.96
 |  |  | K258 | 0.313 | 67.26
 |  |  | A259 | 0.065 | 100.27
 |  |  | N260 | 0.246 | 60.21
 |  |  | V270 | 0.704 | 102.62
 |  |  | D271 | 0.707 | 84.57
 |  |  | T275 | 0.404 | 89.63
 |  |  | D276 | 0.068 | 72.38
 |  |  | K279 | 0.452 | 150.18
 |  |  | P281 | 0.039 | 97.3
 |  |  | W284 | 0.394 | 59.23
 |  |  | F286 | 0.53 | 114.73
 |  |  | Q287 | 0.23 | 81.84
 |  |  | A289 | 0.849 | 52.57
 |  |  | R306 | 0.107 | 150.14
 |  |  | D307 | 0.039 | 58.73
 |  |  | V309 | 0.039 | 120.35
 |  |  | L310 | 0.039 | 90.82
2FZC | B | Surface | D4 | 0.172 | 105.19
 |  |  | N5 | 0.27 | 82.41
 |  |  | K6 | 0.382 | 186.32
 |  |  | L7 | 0.797 | 129.31
 |  |  | Q8 | 0.356 | 66.83
 |  |  | R14 | 0.395 | 90.6
 |  |  | P22 | 0.461 | 55.78
 |  |  | Q24 | 0.606 | 76.34
 |  |  | K28 | 0.487 | 64.91
 |  |  | L32 | 0.514 | 54.92
 |  |  | K34 | 0.264 | 122.15
 |  |  | E37 | 0.257 | 113.99
 |  |  | D39 | 0.191 | 106.52
 |  |  | Q40 | 0.283 | 56.75
 |  |  | P49 | 0.119 | 63.86
 |  |  | G51 | 0.086 | 70.49
 |  |  | M53 | 0.204 | 164.93
 |  |  | R55 | 0.093 | 123.48
 |  |  | F65 | 0.316 | 70.71
 |  |  | E68 | 0.178 | 122.86
 |  |  | D69 | 0.185 | 95
 |  |  | Q70 | 0.77 | 91.49
 |  |  | P79 | 0.882 | 57.88
 |  |  | Q80 | 0.099 | 117.21
 |  |  | R85 | 0.678 | 103.15
 |  |  | D87 | 0.448 | 72.79
 |  |  | V92 | 0.481 | 116.78
 |  |  | S95 | 0.218 | 50.65
 |  |  | R96 | 0.106 | 123.98
 |  |  | S98 | 0.027 | 69.25
 |  |  | L99 | 0.415 | 52.99
 |  |  | E101 | 0.04 | 143.43
 |  |  | R102 | 0.047 | 123.29
 |  |  | N105 | 0.422 | 96.59
 |  |  | V108 | 0.29 | 69.81
 |  |  | S112 | 0.612 | 105.52
 |  |  | N113 | 0.652 | 58.94
 |  |  | H117 | 0.619 | 75.95
 |  |  | A118 | 0.25 | 80.63
 |  |  | P120 | 0.448 | 80.55
 |  |  | S122 | 0.007 | 58.45
 |  |  | R128 | 0.112 | 116.97
 |  |  | K129 | 0.165 | 129.98
 |  |  | R130 | 0.053 | 103.64
 |  |  | A131 | 0.02 | 92.15
 |  |  | N132 | 0.033 | 154.08
 |  |  | K137 | 0.428 | 71.7
 |  |  | K139 | 0.132 | 77.15
 |  |  | K143 | 0.468 | 66.54
 |  |  | E144 | 0.31 | 66.83
 |  |  | N148 | 0.125 | 90.24
 |  |  | V149 | 0.329 | 75.19
 |  |  | L151 | 0.06 | 63.28
 |  |  | A152 | 0.283 | 84.07
 |  |  | N153 | 0.158 | 126.06
Conservation scores of catalytic, allosteric, and surface residues of GPb
PDB | Chain | Type | Residue | Conservation Score | Surface Area (Å2)
7GPB | A | Catalytic Site | Y90 | 0.143 | 31.37
 |  |  | N133 | 0.929 | 41.24
 |  |  | G134 | 0.243 | 33.66
 |  |  | G135 | 0.243 | 47.65
 |  |  | R138 | 0.554 | 10.65
 |  |  | I486 | 0.877 | 1.58
 |  |  | W491 | 0.096 | 0.49
 |  |  | V567 | 0.752 | 15.77
 |  |  | K568 | 0.421 | 29.54
 |  |  | R569 | 0.554 | 128.98
 |  |  | K574 | 0.421 | 24.6
 |  |  | Y648 | 0.143 | 40.68
 |  |  | R649 | 0.554 | 47.49
 |  |  | V650 | 0.752 | 4.22
 |  |  | S651 | 1 | 2.89
 |  |  | A653 | 0.073 | 4.22
 |  |  | I657 | 0.877 | 1.45
 |  |  | Q665 | 0.641 | 8.93
 |  |  | E672 | 0.486 | 27.97
 |  |  | S674 | 1 | 5.61
 |  |  | G675 | 0.243 | 17.46
 |  |  | T676 | 0.971 | 12.14
 |  |  | G677 | 0.243 | 21.55
 |  |  | N678 | 0.929 | 4.19
 |  |  | K680 | 0.421 | 14.55
7GPB | A | [NAME] | W67 | 0.096 | 29
 |  |  | I68 | 0.877 | 7.46
 |  |  | R69 | 0.554 | 75.44
 |  |  | Q71 | 0.641 | 23.06
 |  |  | Q72 | 0.641 | 35.85
 |  |  | H73 | 0.666 | 61.93
 |  |  | Y75 | 0.143 | 56.36
 |  |  | E76 | 0.037 | 111.09
 |  |  | Y155 | 0.143 | 7.87
 |  |  | R193 | 0.554 | 11.98
 |  |  | F196 | 0.187 | 58.54
 |  |  | D227 | 0.606 | 1.76
 |  |  | R242 | 0.554 | 10.27
 |  |  | R309 | 0.554 | 79.92
 |  |  | R310 | 0.554 | 17.81
 |  |  | S313 | 1 | 63.74
 |  |  | S314 | 1 | 0.2
 |  |  | K315 | 0.421 | 109.37
7GPB | A | Surface | R10 | 0.554 | 135.79
 |  |  | K11 | 0.421 | 150.7
 |  |  | Q12 | 0.641 | 79.79
 |  |  | R16 | 0.554 | 167.15
 |  |  | G17 | 0.243 | 57.98
 |  |  | A19 | 0.821 | 56.04
 |  |  | V21 | 0.752 | 51.43
 |  |  | E22 | 0.486 | 88.9
 |  |  | N23 | 0.929 | 56.59
 |  |  | T25 | 0.075 | 82.02
 |  |  | E26 | 0.049 | 54.32
 |  |  | K29 | 0.421 | 114.11
 |  |  | R43 | 0.554 | 87.49
 |  |  | N44 | 0.929 | 100.89
 |  |  | V45 | 0.752 | 87.35
 |  |  | T47 | 0.971 | 61.41
 |  |  | P48 | 0.37 | 69.63
 |  |  | K77 | 0.421 | 130.57
 |  |  | E105 | 0.486 | 51.27
 |  |  | N106 | 0.929 | 128.63
 |  |  | D109 | 0.606 | 63.82
 |  |  | E110 | 0.486 | 64.12
 |  |  | Y113 | 0.143 | 142.77
 |  |  | Q114 | 0.641 | 67.88
 |  |  | D118 | 0.606 | 72.36
 |  |  | E120 | 0.486 | 134.6
 |  |  | E121 | 0.486 | 105.9
 |  |  | E124 | 0.486 | 69.49
 |  |  | E127 | 0.486 | 77.3
 |  |  | E162 | 0.486 | 51.85
 |  |  | K169 | 0.421 | 76.87
 |  |  | C171 | 0.005 | 74.79
 |  |  | G172 | 0.243 | 63.44
 |  |  | W174 | 0.096 | 59.51
 |  |  | M176 | 0.689 | 93.26
 |  |  | E178 | 0.486 | 83.23
 |  |  | A179 | 0.821 | 63.62
 |  |  | D181 | 0.052 | 57.43
 |  |  | R184 | 0.554 | 137.53
 |  |  | Y185 | 0.143 | 53.13
 |  |  | E195 | 0.486 | 70.01
 |  |  | P199 | 0.37 | 60.48
 |  |  | H201 | 0.666 | 61.31
 |  |  | Y203 | 0.143 | 56.1
 |  |  | R205 | 0.055 | 59.02
 |  |  | E207 | 0.486 | 59.83
 |  |  | H208 | 0.666 | 112.33
 |  |  | T209 | 0.971 | 52.26
 |  |  | S210 | 1 | 130.96
 |  |  | Q211 | 0.641 | 136.83
 |  |  | K214 | 0.421 | 91.81
 |  |  | D217 | 0.606 | 97.32
 |  |  | Q219 | 0.641 | 58.89
 |  |  | R234 | 0.554 | 92.88
 |  |  | K247 | 0.421 | 81.31
 |  |  | N250 | 0.016 | 57.4
 |  |  | D251 | 0.041 | 55.62
 |  |  | F252 | 0.187 | 54.19
 |  |  | N253 | 0.929 | 71.21
 |  |  | L254 | 0.328 | 131
 |  |  | K255 | 0.421 | 108.58
 |  |  | D256 | 0.606 | 83.28
 |  |  | F257 | 0.187 | 138.55
 |  |  | N258 | 0.929 | 81.88
 |  |  | G260 | 0.243 | 63.36
 |  |  | G261 | 0.243 | 69.02
 |  |  | Y262 | 0.143 | 57.18
 |  |  | I263 | 0.877 | 57.01
 |  |  | Q264 | 0.641 | 55.16
 |  |  | L271 | 0.328 | 52.21
 |  |  | Y280 | 0.143 | 73.1
 |  |  | P281 | 0.37 | 89.57
 |  |  | E287 | 0.486 | 158.63
 |  |  | G288 | 0.243 | 55.41
 |  |  | K289 | 0.421 | 78.97
 |  |  | E290 | 0.486 | 52.17
 |  |  | Q305 | 0.641 | 56
 |  |  | K312 | 0.421 | 65.36
 |  |  | C318 | 0.02 | 136.46
 |  |  | R319 | 0.036 | 102.18
 |  |  | D320 | 0.606 | 54.59
 |  |  | P321 | 0.37 | 103.31
 |  |  | V322 | 0.752 | 72.04
 |  |  | R323 | 0.554 | 168.38
 |  |  | D327 | 0.606 | 64.2
 |  |  | D331 | 0.606 | 93.54
 |  |  | K332 | 0.421 | 54.71
 |  |  | L356 | 0.03 | 109.81
 |  |  | R358 | 0.554 | 182.8
 |  |  | D360 | 0.058 | 92.33
 |  |  | D362 | 0.058 | 85.99
 |  |  | K363 | 0.421 | 52.87
 |  |  | E366 | 0.017 | 76.83
 |  |  | K370 | 0.04 | 75.62
 |  |  | I380 | 0.328 | 74.17
 |  |  | P381 | 0.37 | 64.43
 |  |  | E382 | 0.486 | 113.36
 |  |  | A383 | 0.821 | 59.08
 |  |  | R386 | 0.554 | 70.8
 |  |  | H390 | 0.666 | 63.26
 |  |  | E393 | 0.486 | 91.2
 |  |  | T394 | 0.971 | 78.77
 |  |  | Q401 | 0.641 | 61
 |  |  | Y404 | 0.143 | 85.71
 |  |  | E405 | 0.486 | 60
 |  |  | Q408 | 0.641 | 118.17
 |  |  | R409 | 0.554 | 85.03
 |  |  | N412 | 0.929 | 98.98
 |  |  | R413 | 0.554 | 107.28
 |  |  | A416 | 0.821 | 88.35
 |  |  | P419 | 0.37 | 97.53
 |  |  | G420 | 0.243 | 76.62
 |  |  | V422 | 0.752 | 112.98
 |  |  | D423 | 0.606 | 59.24
 |  |  | R426 | 0.554 | 71.8
 |  |  | R427 | 0.554 | 105.96
 |  |  | E432 | 0.486 | 62.25
 |  |  | E433 | 0.486 | 88.73
 |  |  | V436 | 0.752 | 78.93
 |  |  | K437 | 0.421 | 69.21
 |  |  | R438 | 0.554 | 76.78
 |  |  | H450 | 0.666 | 66.67
 |  |  | R457 | 0.554 | 99.81
 |  |  | E461 | 0.486 | 64.53
 |  |  | K465 | 0.421 | 110.44
 |  |  | T466 | 0.971 | 97.66
 |  |  | K469 | 0.421 | 77.92
 |  |  | Y472 | 0.143 | 76.98
 |  |  | E473 | 0.486 | 89.56
 |  |  | P476 | 0.37 | 59.21
 |  |  | H477 | 0.666 | 144.99
 |  |  | P497 | 0.37 | 81.29
 |  |  | E501 | 0.486 | 117.51
 |  |  | E505 | 0.486 | 122.54
 |  |  | E509 | 0.486 | 74.45
 |  |  | E510 | 0.002 | 97.37
 |  |  | D516 | 0.606 | 72.81
 |  |  | R519 | 0.554 | 94.15
 |  |  | K520 | 0.421 | 96.37
 |  |  | L522 | 0.328 | 63.58
 |  |  | S523 | 1 | 89.8
 |  |  | Y524 | 0.023 | 57.03
 |  |  | D526 | 0.606 | 76.1
 |  |  | D527 | 0.606 | 52.97
 |  |  | E528 | 0.043 | 76.02
 |  |  | R532 | 0.554 | 140.75
 |  |  | K536 | 0.421 | 95.93
 |  |  | Q539 | 0.641 | 97.06
 |  |  | E540 | 0.486 | 70.14
 |  |  | L543 | 0.328 | 79.8
 |  |  | K544 | 0.421 | 134.55
 |  |  | E550 | 0.486 | 78.65
 |  |  | R551 | 0.006 | 154.01
 |  |  | E552 | 0.486 | 64.31
 |  |  | Y553 | 0.143 | 86.82
 |  |  | K554 | 0.421 | 168.59
 |  |  | H556 | 0.666 | 102.06
 |  |  | N560 | 0.929 | 119.02
 |  |  | R589 | 0.554 | 82.11
 |  |  | K591 | 0.421 | 71.17
 |  |  | K592 | 0.021 | 160.66
 |  |  | E593 | 0.486 | 90.66
 |  |  | N595 | 0.929 | 154.22
 |  |  | K596 | 0.042 | 131.54
 |  |  | F597 | 0.187 | 125.02
 |  |  | P611 | 0.37 | 57.95
 |  |  | G612 | 0.243 | 68.89
 |  |  | Y613 | 0.025 | 53.5
 |  |  | H614 | 0.666 | 94
 |  |  | D628 | 0.606 | 82.78
 |  |  | H632 | 0.666 | 134.85
 |  |  | P634 | 0.37 | 119.32
 |  |  | V635 | 0.008 | 63.15
 |  |  | D638 | 0.606 | 50.38
 |  |  | R639 | 0.554 | 53.88
 |  |  | K655 | 0.421 | 54.79
 |  |  | E701 | 0.486 | 83.81
 |  |  | E705 | 0.486 | 83.42
 |  |  | E706 | 0.049 | 135.1
 |  |  | R714 | 0.554 | 96.18
 |  |  | V715 | 0.752 | 64.3
 |  |  | E716 | 0.486 | 104.28
 |  |  | D719 | 0.01 | 88.61
 |  |  | R720 | 0.053 | 133.07
 |  |  | Q723 | 0.641 | 110.19
 |  |  | R724 | 0.054 | 122.41
 |  |  | E730 | 0.486 | 53.22
 |  |  | D733 | 0.606 | 87.25
 |  |  | R734 | 0.554 | 146.27
 |  |  | P736 | 0.37 | 92.1
 |  |  | R739 | 0.554 | 70.91
 |  |  | Q740 | 0.059 | 79.86
 |  |  | E743 | 0.05 | 102.61
 |  |  | S747 | 1 | 78.2
 |  |  | F749 | 0.187 | 93.18
 |  |  | P752 | 0.37 | 90.7
 |  |  | K753 | 0.421 | 163.49
 |  |  | D756 | 0.606 | 68.2
 |  |  | K759 | 0.421 | 90.1
 |  |  | D760 | 0.606 | 50.74
 |  |  | N763 | 0.929 | 57.78
 |  |  | H767 | 0.666 | 94.81
 |  |  | H768 | 0.666 | 114.36
 |  |  | R770 | 0.554 | 155
 |  |  | E778 | 0.486 | 90.96
 |  |  | E779 | 0.047 | 75.58
 |  |  | K782 | 0.421 | 68.1
 |  |  | E785 | 0.047 | 76.75
 |  |  | R786 | 0.018 | 124.25
 |  |  | L790 | 0.328 | 50.53
 |  |  | K792 | 0.421 | 115.31
 |  |  | N793 | 0.929 | 69.93
 |  |  | P794 | 0.37 | 100.4
 |  |  | R795 | 0.554 | 95.81
 |  |  | E796 | 0.486 | 51.67
 |  |  | R803 | 0.554 | 79.81
 |  |  | R815 | 0.554 | 54.04
 |  |  | Q819 | 0.641 | 61.29
 |  |  | R822 | 0.554 | 133.27
 |  |  | E823 | 0.486 | 92.66
 |  |  | G826 | 0.243 | 50.95
 |  |  | E828 | 0.486 | 114.19
 |  |  | R831 | 0.554 | 88.92
 |  |  | Q832 | 0.641 | 131.38
 |  |  | R833 | 0.554 | 118.33
 |  |  | P835 | 0.37 | 104.44
 |  |  | P837 | 0.37 | 78.51
Conservation scores of catalytic, allosteric, and surface residues of FBPase
PDB | Chain | Type | Residue | Conservation Score | Surface Area (Å2)
2Q8M | A | Catalytic Site | E89 | 0.961 | 40.68
 |  |  | E90 | 0.991 | 77.4
 |  |  | D110 | 0.97 | 7.82
 |  |  | L112 | 0.913 | 42.07
 |  |  | D113 | 1 | 7.62
 |  |  | G114 | 0.976 | 17.62
 |  |  | S115 | 0.985 | 62.3
 |  |  | S116 | 0.943 | 89.23
 |  |  | N206 | 0.949 | 57.13
 |  |  | N209 | 0.813 | 41.8
 |  |  | Y239 | 0.904 | 77.11
 |  |  | G241 | 0.916 | 40.32
 |  |  | S242 | 0.813 | 0.42
 |  |  | L243 | 0.786 | 13.84
 |  |  | V244 | 0.925 | 2.99
 |  |  | D246 | 0.871 | 0.22
 |  |  | [NAME] | 0.822 | 6.56
 |  |  | Y259 | 0.955 | 19.18
 |  |  | H265 | 0.315 | 47.99
 |  |  | K269 | 0.865 | 88.59
 |  |  | L270 | 0.901 | 9.33
 |  |  | E275 | 0.991 | 21.77
2Q8M | A | [NAME] (B6G) | Y203 | 0.641 | 10.35
 |  |  | E207 | 0.611 | 64.45
 |  |  | Y210 | 0.23 | 75.21
 |  |  | K218 | 0.396 | 48.1
 |  |  | I221 | 0.357 | 7.13
 |  |  | K222 | 0.475 | 120.79
 |  |  | Q225 | 0.565 | 99.86
2Q8M | A | [NAME] (AMP) | F7 | 0.284 | 6.61
 |  |  | I8 | 0.629 | 7.15
 |  |  | V9 | 0.281 | 55.82
 |  |  | K11 | 0.2 | 40.76
 |  |  | Q12 | 0.417 | 43.6
 |  |  | F15 | 0.106 | 131.11
 |  |  | H17 | 0.04 | 170.3
 |  |  | A18 | 0.221 | 43.49
 |  |  | T19 | 0.227 | 94.22
 |  |  | G20 | 0.158 | 17.96
 |  |  | E21 | 0.224 | 46.89
 |  |  | L22 | 0.411 | 44.33
 |  |  | T23 | 0.345 | 22.46
 |  |  | L26 | 0.342 | 14.16
 |  |  | K104 | 0.203 | 53.2
 |  |  | Y105 | 0.535 | 11.44
 |  |  | R132 | 0.312 | 125.27
 |  |  | V154 | 0.508 | 27.73
 |  |  | Y169 | 0.372 | 5.84
 |  |  | T171 | 0.324 | 45.75
2Q8M | A | Surface | K2 | 0.266 | 108.46
 |  |  | E10 | 0.257 | 71.69
 |  |  | [NAME] | 0.248 | 101.69
 |  |  | E14 | 0.082 | 118.6
 |  |  | S16 | 0.218 | 103.02
 |  |  | R38 | 0.182 | 77.45
 |  |  | D39 | 0.194 | 53.13
 |  |  | K42 | 0.318 | 112.48
 |  |  | G44 | 0.59 | 93.71
 |  |  | L45 | 0.659 | 154.38
 |  |  | F68 | 0.291 | 198.03
 |  |  | E71 | 0.191 | 116.02
 |  |  | K78 | 0.079 | 102.04
 |  |  | A79 | 0.167 | 83.3
 |  |  | R80 | 0.399 | 63.87
 |  |  | D81 | 0.303 | 63.05
 |  |  | [NAME] | 0.354 | 114.92
 |  |  | E93 | 0.07 | 124.43
 |  |  | V96 | 0.046 | 64.51
 |  |  | E98 | 0.212 | 148.32
 |  |  | E101 | 0.161 | 51.17
 |  |  | H102 | 0.112 | 111.49
 |  |  | I118 | 0.771 | 63.14
 |  |  | D119 | 0.795 | 122.42
 |  |  | V134 | 0.206 | 81.91
 |  |  | P136 | 0.052 | 93.3
 |  |  | V137 | 0.076 | 80.64
 |  |  | T139 | 0.085 | 53.86
 |  |  | P140 | 0.091 | 78.99
 |  |  | T142 | 0.103 | 61.26
 |  |  | E143 | 0.088 | 75.82
 |  |  | E144 | 0.04 | 107.82
 |  |  | N151 | 0.109 | 64.44
 |  |  | K152 | 0.1 | 112.75
 |  |  | C173 | 0.058 | 63.52
 |  |  | P182 | 0.408 | 104.51
 |  |  | L189 | 0.605 | 51.2
 |  |  | C190 | 0.599 | 76.68
 |  |  | Q191 | 0.278 | 86.81
 |  |  | E192 | 0.121 | 98.96
 |  |  | R193 | 0.209 | 118.11
 |  |  | R195 | 0.04 | 155.27
 |  |  | E198 | 0.061 | 143.14
 |  |  | K199 | 0.124 | 109.32
 |  |  | K201 | 0.073 | 112.32
 |  |  | I211 | 0.423 | 126.77
 |  |  | K212 | 0.454 | 123.02
 |  |  | N215 | 0.04 | 62.42
 |  |  | K219 | 0.336 | 87.06
 |  |  | E226 | 0.448 | 86.91
 |  |  | E227 | 0.118 | 135.36
 |  |  | K229 | 0.366 | 174
 |  |  | S230 | 0.297 | 99.36
 |  |  | T231 | 0.62 | 64.66
 |  |  | N232 | 0.097 | 62.25
 |  |  | L252 | 0.185 | 94.33
 |  |  | K253 | 0.825 | 150.74
 |  |  | S264 | 0.127 | 83.11
 |  |  | P266 | 0.351 | 97.26
 |  |  | D267 | 0.067 | 99.58
 |  |  | G287 | 0.849 | 51.34
 |  |  | K289 | 0.197 | 64.89
 |  |  | K294 | 0.176 | 168.15
 |  |  | E295 | 0.04 | 80.08
 |  |  | R296 | 0.469 | 105.17
 |  |  | D299 | 0.556 | 67.1
 |  |  | I301 | 0.04 | 115.87
 |  |  | E303 | 0.04 | 134.57
 |  |  | T304 | 0.04 | 74.54
 |  |  | R308 | 0.886 | 78.46
 |  |  | R309 | 0.562 | 62.23
 |  |  | D316 | 0.094 | 61.59
 |  |  | H317 | 0.152 | 70.26
 |  |  | E320 | 0.058 | 84.85
 |  |  | R324 | 0.04 | 86.28
 |  |  | R327 | 0.04 | 154.23
 |  |  | E328 | 0.04 | 97.62
 |  |  | F329 | 0.04 | 81.48
 |  |  | P330 | 0.04 | 94.52
 |  |  | D331 | 0.046 | 77.54
 |  |  | A332 | 0.04 | 162.49