Spreadsheet: 23e72da9-f850-4b3a-9725-e930f811dba8
Sheet: Sheet1

Table S4 Comparisons between CSB-PGBD3 binding sites and genes up and down regulated by CSB, CSB-PGBD3, or both in UVSS1KO and by CSB rescue of CS1AN | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8
1 Mb [NAME] |  | All Peaks (2087) | MER85 peaks (331) | TRE Peaks (585) | TEAD Peaks (269) | CTCF Peaks(58) | [NAME] (105) | Other peaks (803)
Cell Line | 2-fold direction | p-value | p-value | p-value | p-value | p-value | p-value | p-value
[NAME] | Down | 8.245208e-05 | 0.8644152 | 0.003633917 | 0.09334439 | 0.001417107 | 0.016203 | 0.01725974
[NAME] | Up | 0.06126812 | 0.2215662 | 0.04541507 | 0.04456326 | 0.09254548 | 0.4706667 | 0.7018108
[NAME] | Down | 1.899721e-11 | 0.1033286 | 0.0001392842 | 0.002197183 | 0.1156809 | 0.09878553 | 1.068591e-06
[NAME] | Up | 1.268986e-08 | 0.1615441 | 1.374968e-05 | 0.08533801 | 0.00646022 | 0.06380306 | 0.0004332603
UVSS1KO + CSB + CSB-PGBD3 | Down | 1.411487e-06 | 0.2913613 | 0.0004099889 | 0.5871975 | 0.03251938 | 0.02182432 | 0.0005163929
UVSS1KO + CSB + CSB-PGBD3 | Up | 4.840108e-15 | 0.07055151 | 5.805314e-06 | 0.0004301851 | 0.008811373 | 8.695553e-06 | 6.359102e-06
CS1AN CSB Rescue | Down | 2.818981e-20 | 0.3341354 | 2.73069e-09 | 5.315366e-06 | 0.00197388 | 0.003184938 | 8.642948e-10
CS1AN CSB Rescue | Up | 0.04689999 | 0.538103 | 0.05583023 | 0.09837071 | 0.1346166 | 0.01246591 | 0.5375694
250kb Regulatory Domains |  | All Peaks (2087) | MER85 peaks (331) | TRE Peaks (585) | TEAD Peaks (269) | CTCF Peaks(58) | [NAME] (105) | Other peaks (803)
Cell Line | 2-fold direction | p-value | p-value | p-value | p-value | p-value | p-value | p-value
[NAME] | Down | 0.03669714 | 0.8505367 | 0.07907143 | 0.3738345 | 0.1549645 | 0.12897 | 0.1058787
[NAME] | Up | 0.4258849 | 0.2587592 | 0.3663031 | 0.3492718 | 0.3507271 | 1 | 0.7291078
[NAME] | Down | 2.896084e-11 | 0.03019853 | 3.466365e-05 | 0.0003599061 | 0.1101144 | 0.1287358 | 3.901528e-05
[NAME] | Up | 1.728607e-05 | 0.2328041 | 3.907639e-05 | 0.006111932 | 0.01574565 | 0.04078319 | 0.1947056
UVSS1KO + CSB + CSB-PGBD3 | Down | 0.1351443 | 0.8836564 | 0.1196203 | 0.3150597 | 0.01287684 | 0.5049475 | 0.3392557
UVSS1KO + CSB + CSB-PGBD3 | Up | 4.957025e-13 | 0.0182704 | 0.0002393959 | 0.001397599 | 0.01555173 | 9.481335e-07 | 0.0003236795
CS1AN CSB Rescue | Down | 1.201374e-25 | 0.116389 | 1.685878e-07 | 1.932902e-07 | 0.004678493 | 0.009793764 | 3.265964e-12
CS1AN CSB Rescue | Up | 0.2324702 | 0.6054397 | 0.05184685 | 0.1764011 | 0.3250469 | 0.000623879 | 0.9286159
100kb Regulatory Domains |  | All Peaks (2087) | MER85 peaks (331) | TRE Peaks (585) | TEAD Peaks (269) | CTCF Peaks(58) | [NAME] (105) | Other peaks (803)
Cell Line | 2-fold direction | p-value | p-value | p-value | p-value | p-value | p-value | p-value
[NAME] | Down | 0.5594269 | 0.6501219 | 0.6571514 | 0.9142648 | 0.01152149 | 0.5285498 | 0.5526144
[NAME] | Up | 0.6502104 | 0.4009479 | 0.4059092 | 0.2115935 | 1 | 1 | 0.9208775
[NAME] | Down | 1.316097e-05 | 0.07221847 | 0.006212448 | 0.07063596 | 0.05431494 | 0.3243661 | 0.01738921
[NAME] | Up | 0.007066947 | 0.102795 | 0.002790983 | 0.1525671 | 0.005269085 | 0.3939123 | 0.6858682
UVSS1KO + CSB + CSB-PGBD3 | Down | 0.215784 | 0.6862215 | 0.4507601 | 0.2135611 | 0.07647882 | 0.9623257 | 0.3006345
UVSS1KO + CSB + CSB-PGBD3 | Up | 7.53921e-06 | 0.05646706 | 0.004644702 | 0.009568987 | 0.2861811 | 0.003647069 | 0.09974358
CS1AN CSB Rescue | Down | 1.369329e-18 | 0.02707996 | 1.763415e-05 | 1.170564e-06 | 0.05893174 | 0.002211591 | 1.813054e-07
CS1AN CSB Rescue | Up | 0.8944263 | 0.816324 | 0.3732825 | 0.1941731 | 1 | 0.6291598 | 0.9913427