Spreadsheet: 301322ec-0da5-46c9-bfe8-7fa07cf735d7
Sheet: Sheet1

Unnamed: 0 | Unnamed: 1 | Legend | Unnamed: 3 | Unnamed: 4
 |  | +: Faster growth compared to BRD948
 |  | -: Slower growth compared to BRD948
 |  | 0: No difference from BRD948
Condition | Mode of Action | BRD948-pHCM1 | BRD948-pSTY7 | (MIC)
Sanguinarine | ATPase, Na+/K+ and Mg++ | 0 | +
5,7-Dichloro-8-hydroxy-quinaldine | chelator, lipophilic | + | 0
8-Hydroxyquinoline | chelator, lipophilic | - | 0
2-Phenylphenol | DNA intercalator | - | 0
Acriflavine | DNA intercalator | + | 0
Oxolinic acid | DNA unwinding, gyrase (GN), topoisomerase (GP), quinolone | + | 0
Trimethoprim | folate synthesis, dihyldrofolate reductase inhibitor | + | +
Benserazide | fungicide | + | 0
[NAME] | fungicide | 0 | +
Captan | fungicide, carbamate, multisite | + | -
[NAME] | fungicide, phenylsulphamide | + | +
Tolylfluanid | fungicide, phenylsulphamide | + | 0
D-Serine | inhibits 3PGA dehydrogenase (L-serine and pantothenate synthesis) | + | +
o-Cresol | membrane | - | -
Phenylethanol | membrane | + | +
Colistin | membrane, cyclic peptide | + | +
5% Potassium Chloride | osmotic sensitivity, KCl | + | +
6% Potassium Chloride | osmotic sensitivity, KCl | 0 | +
3% NaCl | osmotic sensitivity, [NAME] | 0 | +
4% NaCl | osmotic sensitivity, [NAME] | 0 | +
5% NaCl | osmotic sensitivity, [NAME] | 0 | +
2% Sodium Lactate | osmotic sensitivity, sodium lactate | + | +
1-Chloro-2,4-dinitrobenzene | oxidation, glutathione | 0 | -
Potassium superoxide | oxidizing agent | + | +
pH 9.5 + L-Serine | pH, deaminase | 0 | -
pH 9.5 + L-Threonine | pH, deaminase | 0 | -
pH 4.5 + L-Lysine | pH, decarboxylase | - | -
pH 10 | pH, growth at 10 | 0 | -
Chloramphenicol | protein synthesis | + | +
Streptomycin | protein synthesis, 30S ribosomal subunit, aminoglycoside | + | +
Rolitetracycline | protein synthesis, 30S ribosomal subunit, tetracycline | + | +
Gentamicin | protein synthesis, aminoglycoside | + | +
Streptomycin | protein synthesis, aminoglycoside | + | +
Troleandomycin | protein synthesis, macrolide | - | 0
Chlortetracycline | protein synthesis, tetracycline | + | +
Demeclocyline | protein synthesis, tetracycline | + | +
Doxycycline | protein synthesis, tetracycline | + | +
Minocycline | protein synthesis, tetracycline | + | +
Oxytetracycline | protein synthesis, tetracycline | + | +
Penimepicycline | protein synthesis, tetracycline | + | +
Tetracycline | protein synthesis, tetracycline | + | +
Iodonitro tetrazolium violet | respiration | - | -
Guanazole | ribonucleotide DP reductase | - | -
Rifampicin | RNA polymerase | - | -
[NAME] | RNA polymerase | + | +
Sodium cyanate | toxic anion | + | 0
Lithium chloride | toxic cation | - | -
Zinc chloride | toxic cation | + | 0
Phenylarsine oxide | tyrosine phosphatase inhibitor | - | -
Cefazolin | wall, cephalosporin | + | +
Cefotaxime | wall, cephalosporin | + | + | *MIC ≤0.125 mg/mL for both isolates; same for cefepime, ceftazidime
Ceftriaxone | wall, cephalosporin | + | +
Cephalothin | wall, cephalosporin | + | +
Cefmetazole | wall, cephalosporin second generation | 0 | +
Cefoxitin | wall, cephalosporin second generation | 0 | -
Cefoperazone | wall, cephalosporin third generation | + | +
Amoxicillin | wall, lactam | + | +
[NAME] | wall, lactam | + | +
[NAME] | wall, lactam | - | -
Nafcillin | wall, lactam | + | 0
Oxacillin | wall, lactam | + | +
Penicillin G | wall, lactam | + | +
Phenethicillin | wall, lactam | + | +
1-Hydroxy- pyridine-2-thione |  | + | 0