Spreadsheet: 2ec0c6a2-56a8-4a2f-8ff3-5bdf5e42bcad
Sheet: TS3

Table S3. Effect of sex and age on face shape in discovery cohorts
 |  | Male |  |  | Female
 |  | N=2433 |  |  | N=2955
Phenotype |  | Mean | SD |  | Mean | SD |  | P_sex |  | beta | P_age
Centroid Size |  | 151.249316537074 | 5.19021432396205 |  | 140.855290125824 | 4.68237477792449 |  | 0 |  | -0.0133553735098571 | 0.00373250007825601
ZygR-ZygL |  | 133.466689063908 | 5.3182972817715 |  | 125.190876399443 | 4.79669980917314 |  | 1.68763492924542e-12 |  | 0.0770757918569214 | 1.86477613466114e-111
ZygR-EyeR |  | 58.6766909655655 | 2.96228335758888 |  | 53.9256821280223 | 2.76750303500155 |  | 3.17719377059978e-45 |  | 0.0339211799519914 | 1.11560081454696e-53
[NAME] |  | 110.215819210676 | 4.20635197269843 |  | 103.032833667627 | 3.9213050182627 |  | 8.91531984124543e-17 |  | 0.0581930768499787 | 1.9757545976517e-113
ZygR-AlrR |  | 82.0114509509463 | 3.53567008486227 |  | 77.2518027368612 | 3.4120900243839 |  | 7.15745111344247e-28 |  | -0.0333970551920342 | 5.10122556777287e-63
[NAME] |  | 109.557339032207 | 4.08091971175309 |  | 101.768798929936 | 3.61857411896691 |  | 2.01691426475144e-21 |  | 0.00649241278214385 | 0.000228117437990175
[NAME] |  | 98.8960867943465 | 3.52452575253925 |  | 91.7890271200013 | 3.25839385617495 |  | 4.81043600159854e-96 |  | 0.0288390608858545 | 1.16721984687202e-38
[NAME] |  | 113.282365794385 | 4.34119721929635 |  | 104.492160725493 | 4.0904755021258 |  | 9.65001996605459e-51 |  | -0.0306605500670438 | 1.076467557346e-49
ZygR-Sbn |  | 101.797398249401 | 4.28075130023944 |  | 94.5664033261645 | 3.98895352879881 |  | 2.72685230629524e-07 |  | -0.0284322701877438 | 8.53001871983604e-56
ZygL-EyeR |  | 110.005889496111 | 4.31230499749275 |  | 102.987595043071 | 3.99207598074262 |  | 1.75240891924551e-08 |  | 0.0604256521019597 | 4.20735188531424e-116
ZygL-EyeL |  | 58.452741937736 | 3.02646116180642 |  | 53.8506250392447 | 2.82279407313911 |  | 2.40812845709511e-34 |  | 0.0426324855602552 | 1.16023940425401e-79
ZygL-AlrR |  | 108.792032623586 | 4.06308078898632 |  | 101.19149862306 | 3.58428653253442 |  | 1.87848510882772e-16 |  | 0.00565950438733191 | 0.00156643375122432
ZygL-AlrL |  | 81.6610183985537 | 3.49709419475789 |  | 76.972723607472 | 3.36007378243138 |  | 7.6970964439283e-36 |  | -0.0205887480195323 | 1.68273769742243e-26
ZygL-Nsn |  | 98.8440242516248 | 3.59356502724844 |  | 91.8562289220589 | 3.2823813307551 |  | 1.23442282732529e-79 |  | 0.0298290111810724 | 1.21735456203117e-39
[NAME] |  | 113.244140644661 | 4.36629123853545 |  | 104.458156838042 | 4.05163309154613 |  | 6.06942424164505e-52 |  | -0.0326491339325017 | 6.14015320395011e-57
ZygL-Sbn |  | 101.376749355197 | 4.20333523530641 |  | 94.2327005201433 | 3.84060797480407 |  | 6.91986070430586e-05 |  | -0.0296750630829632 | 5.98577899038296e-66
EyeR-EyeL |  | 65.1616136761391 | 3.28154614346797 |  | 61.5781991315108 | 3.12834645897162 |  | 0.00213974365844896 |  | 0.0267218515469201 | 1.19157755981742e-27
EyeR-AlrR |  | 46.1584411753358 | 4.2224678037338 |  | 44.4155837126238 | 3.89515372531145 |  | 7.15110095082465e-159 |  | -0.0395696490344381 | 8.60529306954622e-41
EyeR-AlrL |  | 68.7519165007821 | 3.83660906517712 |  | 64.3709089573448 | 3.15965396008873 |  | 1.7891620981297e-59 |  | -0.0039053508152253 | 0.0522152008694884
EyeR-Nsn |  | 41.4395768142081 | 2.18747321286287 |  | 39.046769021062 | 1.98744483430849 |  | 7.84289628850849e-09 |  | -0.00028577257007898 | 0.869882167226984
EyeR-Prn |  | 66.9140236922586 | 4.25902594879903 |  | 62.3130753965973 | 3.98017180018862 |  | 3.93655882907798e-25 |  | -0.0371991353441291 | 3.11996132219225e-40
EyeR-Sbn |  | 62.9027515683477 | 5.20338080618852 |  | 59.2149118141284 | 4.74893844098769 |  | 1.58725282375914e-128 |  | -0.0433318131965497 | 1.08962099597677e-38
EyeL-AlrR |  | 68.2692615905324 | 3.75791093708132 |  | 64.1121152067509 | 3.08910149603185 |  | 6.71452577797572e-66 |  | -0.00613264934510389 | 0.00203698344901823
EyeL-AlrL |  | 46.3218251074254 | 4.2424379275681 |  | 44.5731658202191 | 3.94305365030018 |  | 3.2877179846505e-162 |  | -0.027626126066514 | 2.34713211047111e-20
EyeL-Nsn |  | 41.6479995980813 | 2.23787653689017 |  | 39.2399957210232 | 1.98369947399671 |  | 2.98998109937054e-09 |  | -0.00729426344636307 | 3.52864443007177e-05
EyeL-Prn |  | 67.1440687798951 | 4.30123545385602 |  | 62.5670751703709 | 4.00860210919891 |  | 2.97970782058079e-25 |  | -0.041242690469511 | 8.92075490453997e-48
EyeL-Sbn |  | 62.8303893874392 | 5.15674121850178 |  | 59.2522069653292 | 4.64363057613537 |  | 3.54560285941117e-127 |  | -0.0445785361935496 | 1.24147047175453e-41
AlrR-AlrL |  | 39.1513651702918 | 2.98449462149606 |  | 34.7770616760002 | 2.54841607414217 |  | 1.56602694157486e-87 |  | 0.0207531902304234 | 1.45899889139092e-18
AlrR-Nsn |  | 50.3680723393492 | 4.21871486550857 |  | 46.6918487883606 | 3.51205579358378 |  | 8.52874700807825e-14 |  | -0.0106801522699107 | 0.000309998455873907
[NAME] |  | 33.035467537082 | 2.273800215605 |  | 29.0017443316241 | 2.00959214159155 |  | 2.71289317917401e-141 |  | -0.00996506102557268 | 1.68937537735865e-08
AlrR-Sbn |  | 22.1315962708408 | 1.92703553749908 |  | 19.5142420278237 | 1.46956617900913 |  | 1.0996608505756e-32 |  | 0.00718632543246715 | 7.2603044825476e-08
AlrL-Nsn |  | 50.8154991613887 | 4.23026867550182 |  | 46.942009832757 | 3.53605627042405 |  | 7.15900898230063e-12 |  | -0.00931631432828551 | 0.00156731486443489
AlrL-Prn |  | 33.419783387965 | 2.29615088428654 |  | 29.2427082581294 | 2.0868151986642 |  | 9.33120519420809e-158 |  | -0.0234901861254478 | 9.14893423788756e-39
AlrL-Sbn |  | 22.2189457610309 | 1.82882956072121 |  | 19.5947490627413 | 1.44884529210981 |  | 8.98771931384513e-61 |  | -0.00561300406638283 | 2.46291888135818e-05
[NAME] |  | 47.7024232009112 | 4.62665488957301 |  | 43.8185623249969 | 4.20521658807495 |  | 1.88751879442956e-21 |  | -0.016782171181535 | 7.37425424847643e-07
[NAME] |  | 52.6602924130684 | 5.95597131046779 |  | 48.9209163073933 | 5.26574830027065 |  | 3.42176249099843e-54 |  | -0.0392099388395404 | 8.59998359104263e-20
Prn-Sbn |  | 21.0905112393127 | 2.03669364140943 |  | 18.9345133230881 | 1.95352836759752 |  | 2.68843012938175e-23 |  | -0.0321358224924722 | 2.74715046584362e-78
PC1 |  | 5.34893859360602 | 6.04003546915989 |  | -4.40404994864414 | 5.47162750720139 |  | 3.87269935471612e-72 |  | -0.0338533174708651 | 4.45293171462672e-69
PC2 |  | 2.27319491962889 | 5.11155985883593 |  | -1.87163561402947 | 4.80620926822697 |  | 5.39232376837159e-94 |  | 0.0679018168802675 | 1.6922746585196e-49
PC3 |  | -0.0377873942495459 | 4.12228837662786 |  | 0.0311122606460779 | 3.55029430100156 |  | 3.59236005149704e-05 |  | -0.0892312232062208 | 4.82341956706334e-146
PC4 |  | -0.0147455211931317 | 2.71311785238498 |  | 0.0121407286168777 | 2.59478923812026 |  | 0.00170835325832545 |  | -0.0104563241138598 | 2.43466628753993e-05
PC5 |  | 0.321344798733107 | 2.28505580439347 |  | -0.264579321596494 | 2.10790532427554 |  | 4.81929362685615e-36 |  | 0.0129950492580136 | 1.72986760624115e-10
PC6 |  | -0.54256462968477 | 1.88453488780859 |  | 0.446720725557718 | 1.89642052411591 |  | 5.45256449623499e-192 |  | 0.0121513111066836 | 6.24504815314201e-13
PC7 |  | -0.0119916637243739 | 1.9863942166194 |  | 0.00987333937102695 | 1.73167649225045 |  | 0.358593804694046 |  | -0.0132559684897396 | 1.85663376668561e-14
PC8 |  | -0.00494036434067313 | 1.82026775352003 |  | 0.00406765023379539 | 1.57901906124161 |  | 0.653501577896666 |  | 0.00248606962213593 | 0.117090378652934
PC9 |  | 0.11572410634567 | 1.70396299659228 |  | -0.0952814723313133 | 1.55529143275818 |  | 6.72498809208733e-12 |  | 0.013704684273227 | 1.30872866867784e-19
PC10 |  | -0.0435640394012551 | 1.41255815384343 |  | 0.0358684628978903 | 1.20430558986822 |  | 0.00171702708286665 |  | -0.00936030131724241 | 1.45766762324351e-14
PC11 |  | 0.0283172160747176 | 1.36633675240641 |  | -0.023314987042231 | 1.1839939470626 |  | 0.00388649377546767 |  | -0.00326404002298628 | 0.00605998329901427
Distances are presented in millimeters. P values were adjusted for centroid size.