Spreadsheet: 202fa145-b615-4ca1-a559-938668b2a625
Sheet: Sheet1

Supplemental Table 6. Enrichment of essential proteins in modules derived from the combined network | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4
E/NE(%) represent the percentage of essential/non essential components within the module.
42 essential functional modules were predicted at p-value < 0.1.
P-values were calculated based on expectation using 10000 random modules of equal size. * = p-value < 0.1; ** = p-value < 0.01; *** = p-value < 0.001
Module# | COGs | Size | E/NE (%) | p-value
1 | S | 64 | E 20 N 79 | 0***
2 | S | 55 | E 18 N 81 | 0***
3 | S | 36 | E 8 N 91 | 0***
4 | J | 34 | E 50 N 50 | 0***
5 | S | 31 | E 25 N 74 | 0***
6 | O | 24 | E 20 N 79 | 0***
7 | S | 21 | E 14 N 85 | 0***
8 | S | 20 | E 55 N 45 | 0***
9 | M | 18 | E 55 N 44 | 0***
10 | S | 17 | E 11 N 88 | 0***
11 | S | 16 | E 18 N 81 | 0***
12 | S | 16 | E 31 N 68 | 0***
13 | S | 15 | E 53 N 46 | 0.0005***
14 | L | 15 | E 33 N 66 | 0.0443*
15 | NT | 14 | E 28 N 71 | 0.1099
16 | G | 14 | N 100
17 | S | 14 | E 7 N 92 | 0.8666
18 | S | 13 | E 15 N 84 | 0.5328
19 | S | 13 | N 100
20 | J | 12 | E 41 N 58 | 0.015*
21 | NU | 12 | E 16 N 83 | 0.4978
22 | E | 12 | E 25 N 75 | 0.2191
23 | S | 12 | E 8 N 91 | 0.8274
24 | C | 11 | N 100
25 | G | 11 | E 9 N 90 | 0.792
26 | L | 10 | E 80 N 20 | 0***
27 | C | 10 | E 20 N 80 | 0.4018
28 | TK | 10 | E 10 N 90 | 0.769
29 | C | 9 | E 22 N 77 | 0.3428
30 | S | 9 | E 22 N 77 | 0.3428
31 | C | 9 | E 11 N 88 | 0.7304
32 | G | 9 | N 100
33 | S | 9 | E 22 N 77 | 0.3428
34 | S | 9 | N 100
35 | NU | 9 | N 100
36 | S | 9 | E 11 N 88 | 0.7304
37 | E | 8 | N 100
38 | S | 8 | E 12 N 87 | 0.6791
39 | S | 8 | E 25 N 75 | 0.2919
40 | S | 8 | E 12 N 87 | 0.6791
41 | S | 8 | N 100
42 | E | 8 | E 37 N 62 | 0.0792*
43 | E | 7 | N 100
44 | S | 7 | E 28 N 71 | 0.2385
45 | S | 7 | N 100
46 | H | 7 | E 57 N 42 | 0.0083**
47 | S | 7 | N 100
48 | L | 7 | E 14 N 85 | 0.6402
49 | S | 7 | N 100
50 | S | 7 | E 28 N 71 | 0.2385
51 | F | 7 | E 14 N 85 | 0.6402
52 | K | 7 | E 14 N 85 | 0.6402
53 | S | 7 | E 14 N 85 | 0.6402
54 | S | 7 | N 100
55 | S | 7 | N 100
56 | S | 7 | N 100
57 | C | 7 | N 100
58 | G | 7 | E 14 N 85 | 0.6402
59 | H | 7 | N 100
60 | S | 7 | E 14 N 85 | 0.6402
61 | E | 7 | E 14 N 85 | 0.6402
62 | P | 7 | N 100
63 | U | 6 | E 16 N 83 | 0.5765
64 | S | 6 | E 66 N 33 | 0.0038**
65 | S | 6 | E 33 N 66 | 0.1834
66 | S | 6 | N 100
67 | S | 6 | N 100
68 | S | 6 | E 16 N 83 | 0.5765
69 | S | 6 | E 16 N 83 | 0.5765
70 | S | 6 | N 100
71 | H | 6 | E 83 N 16 | 0.0002***
72 | S | 6 | N 100
73 | T | 6 | N 100
74 | S | 6 | E 16 N 83 | 0.5765
75 | S | 6 | E 16 N 83 | 0.5765
76 | H | 6 | N 100
77 | S | 6 | E 50 N 50 | 0.0337*
78 | S | 6 | E 16 N 83 | 0.5765
79 | S | 6 | E 16 N 83 | 0.5765
80 | S | 6 | E 33 N 66 | 0.1834
81 | S | 6 | E 33 N 66 | 0.1834
82 | S | 6 | E 16 N 83 | 0.5765
83 | G | 6 | E 33 N 66 | 0.1834
84 | S | 6 | N 100
85 | M | 6 | N 100
86 | O | 6 | E 16 N 83 | 0.5765
87 | CP | 6 | N 100
88 | S | 6 | N 100
89 | S | 6 | N 100
90 | G | 6 | N 100
91 | S | 6 | E 16 N 83 | 0.5765
92 | S | 5 | E 40 N 60 | 0.1352
93 | Q | 5 | N 100
94 | M | 5 | N 100
95 | S | 5 | N 100
96 | S | 5 | N 100
97 | E | 5 | E 20 N 80 | 0.5037
98 | P | 5 | N 100
99 | S | 5 | E 40 N 60 | 0.1352
100 | G | 5 | N 100
101 | C | 5 | N 100
102 | S | 5 | N 100
103 | S | 5 | N 100
104 | F | 5 | E 20 N 80 | 0.5037
105 | S | 5 | E 60 N 40 | 0.0193*
106 | TK | 5 | N 100
107 | P | 5 | E 20 N 80 | 0.5037
108 | C | 5 | E 20 N 80 | 0.5037
109 | C | 5 | E 40 N 60 | 0.1352
110 | P | 5 | N 100
111 | H | 5 | N 100
112 | S | 5 | E 20 N 80 | 0.5037
113 | S | 5 | E 20 N 80 | 0.5037
114 | P | 5 | E 20 N 80 | 0.5037
115 | F | 5 | E 40 N 60 | 0.1352
116 | G | 5 | N 100
117 | L | 5 | N 100
118 | S | 5 | N 100
119 | S | 5 | E 20 N 80 | 0.5037
120 | S | 5 | N 100
121 | E | 4 | E 25 N 75 | 0.4382
122 | G | 4 | E 25 N 75 | 0.4382
123 | S | 4 | E 25 N 75 | 0.4382
124 | S | 4 | E 75 N 25 | 0.0101*
125 | E | 4 | E 25 N 75 | 0.4382
126 | C | 4 | N 100
127 | S | 4 | N 100
128 | S | 4 | N 100
129 | G | 4 | N 100
130 | S | 4 | N 100
131 | D | 4 | E 75 N 25 | 0.0101*
132 | D | 4 | E 25 N 75 | 0.4382
133 | NU | 4 | N 100
134 | H | 4 | E 25 N 75 | 0.4382
135 | C | 4 | E 50 N 50 | 0.091*
136 | I | 4 | E 25 N 75 | 0.4382
137 | S | 4 | N 100
138 | S | 4 | N 100
139 | P | 4 | N 100
140 | S | 4 | N 100
141 | S | 4 | E 25 N 75 | 0.4382
142 | P | 4 | N 100
143 | T | 4 | E 25 N 75 | 0.4382
144 | U | 4 | E 50 N 50 | 0.091*
145 | S | 4 | E 25 N 75 | 0.4382
146 | C | 4 | N 100
147 | S | 4 | E 25 N 75 | 0.4382
148 | M | 4 | N 100
149 | S | 4 | N 100
150 | C | 4 | N 100
151 | S | 4 | E 50 N 50 | 0.091*
152 | S | 4 | N 100
153 | E | 4 | E 25 N 75 | 0.4382
154 | C | 4 | N 100
155 | S | 4 | N 100
156 | S | 4 | N 100
157 | E | 4 | E 25 N 75 | 0.4382
158 | S | 4 | E 75 N 25 | 0.0101*
159 | P | 4 | N 100
160 | S | 4 | N 100
161 | S | 4 | E 25 N 75 | 0.4382
162 | C | 4 | E 25 N 75 | 0.4382
163 | S | 4 | E 25 N 75 | 0.4382
164 | S | 4 | E 25 N 75 | 0.4382
165 | S | 4 | E 75 N 25 | 0.0101*
166 | S | 4 | E 50 N 50 | 0.091*
167 | S | 4 | N 100
168 | S | 4 | E 25 N 75 | 0.4382
169 | S | 4 | N 100
170 | S | 4 | N 100
171 | S | 4 | N 100
172 | S | 4 | N 100
173 | S | 4 | N 100
174 | C | 4 | N 100
175 | S | 4 | E 25 N 75 | 0.4382
176 | G | 4 | E 25 N 75 | 0.4382
177 | C | 4 | N 100
178 | S | 4 | N 100
179 | S | 4 | N 100
180 | T | 4 | N 100
181 | S | 4 | N 100
182 | G | 4 | N 100
183 | S | 4 | N 100
184 | S | 4 | N 100
185 | M | 4 | N 100
186 | F | 4 | N 100
187 | S | 4 | N 100
188 | E | 3 | N 100
189 | E | 3 | E 100 | 0.0025**
190 | O | 3 | N 100
191 | S | 3 | E 66 N 33 | 0.049*
192 | J | 3 | E 33 N 66 | 0.3536
193 | S | 3 | E 33 N 66 | 0.3536
194 | S | 3 | N 100
195 | J | 3 | E 100 | 0.0025**
196 | I | 3 | E 33 N 66 | 0.3536
197 | F | 3 | N 100
198 | EF | 3 | N 100
199 | I | 3 | N 100
200 | I | 3 | N 100
201 | O | 3 | N 100
202 | EG | 3 | N 100
203 | EH | 3 | N 100
204 | K | 3 | N 100
205 | D | 3 | E 100 | 0.0025**
206 | S | 3 | N 100
207 | S | 3 | E 33 N 66 | 0.3536
208 | J | 3 | N 100
209 | M | 3 | N 100
210 | M | 3 | E 100 | 0.0025**
211 | NU | 3 | N 100
212 | E | 3 | N 100
213 | S | 3 | N 100
214 | S | 3 | N 100
215 | O | 3 | E 33 N 66 | 0.3536
216 | P | 3 | N 100
217 | G | 3 | N 100
218 | S | 3 | E 66 N 33 | 0.049*
219 | S | 3 | N 100
220 | S | 3 | N 100
221 | I | 3 | N 100
222 | P | 3 | E 33 N 66 | 0.3536
223 | G | 3 | N 100
224 | G | 3 | N 100
225 | S | 3 | N 100
226 | S | 3 | N 100
227 | S | 3 | E 33 N 66 | 0.3536
228 | S | 3 | E 33 N 66 | 0.3536
229 | O | 3 | E 33 N 66 | 0.3536
230 | S | 3 | E 33 N 66 | 0.3536
231 | V | 3 | N 100
232 | E | 3 | N 100
233 | T | 3 | N 100
234 | S | 3 | N 100
235 | V | 3 | N 100
236 | S | 3 | E 33 N 66 | 0.3536
237 | S | 3 | E 33 N 66 | 0.3536
238 | G | 3 | N 100
239 | S | 3 | N 100
240 | G | 3 | N 100
241 | S | 3 | N 100
242 | I | 3 | N 100
243 | S | 3 | N 100
244 | P | 3 | N 100
245 | O | 3 | N 100
246 | E | 3 | N 100
247 | S | 3 | E 66 N 33 | 0.049*
248 | S | 3 | N 100
249 | E | 3 | N 100
250 | S | 3 | E 33 N 66 | 0.3536
251 | V | 3 | N 100
252 | S | 3 | N 100
253 | V | 3 | N 100
254 | GEP | 3 | N 100
255 | O | 3 | N 100
256 | S | 3 | N 100
257 | S | 3 | N 100
258 | C | 3 | N 100
259 | S | 3 | N 100
260 | S | 3 | N 100
261 | K | 3 | N 100
262 | M | 3 | N 100
263 | G | 3 | N 100
264 | S | 3 | N 100
265 | J | 3 | E 66 N 33 | 0.049*
266 | S | 3 | E 66 N 33 | 0.049*
267 | G | 3 | N 100
268 | S | 3 | N 100
269 | S | 3 | N 100
270 | P | 3 | N 100
271 | S | 3 | N 100
272 | C | 3 | N 100
273 | S | 3 | N 100
274 | S | 3 | N 100
275 | L | 3 | E 66 N 33 | 0.049*
276 | C | 3 | N 100
277 | S | 3 | N 100
278 | G | 3 | N 100
279 | H | 3 | E 33 N 66 | 0.3536
280 | E | 3 | N 100
281 | H | 3 | N 100
282 | V | 3 | N 100
283 | G | 3 | N 100
284 | S | 3 | E 33 N 66 | 0.3536
285 | T | 3 | N 100
286 | O | 3 | N 100
287 | C | 3 | E 33 N 66 | 0.3536
288 | S | 3 | N 100
289 | C | 3 | N 100
290 | F | 3 | N 100
291 | S | 3 | N 100
292 | FP | 3 | N 100
293 | F | 3 | E 100 | 0.0025**
294 | E | 3 | N 100
295 | E | 3 | N 100
296 | S | 3 | N 100
297 | G | 3 | N 100
298 | E | 3 | N 100
299 | GT | 3 | E 33 N 66 | 0.3536
300 | E | 3 | N 100
301 | C | 3 | N 100
302 | C | 3 | N 100
303 | J | 3 | E 33 N 66 | 0.3536
304 | E | 3 | N 100
305 | G | 3 | E 33 N 66 | 0.3536
306 | P | 3 | N 100
307 | G | 3 | N 100
308 | G | 3 | N 100
309 | M | 3 | E 33 N 66 | 0.3536
310 | S | 3 | N 100
311 | M | 3 | N 100
312 | M | 3 | N 100
313 | S | 3 | E 66 N 33 | 0.049*
314 | G | 3 | N 100
315 | C | 3 | N 100
316 | NU | 3 | N 100