Spreadsheet: 1664d334-7f7b-48e4-b604-6562ae49621c
Sheet: Sheet1

Abbreviation | Name | Equation | Subsystem | Gene | Protein | Protein Classification
NH3t | ammonia reversible transport | nh3[e] <==> nh3[c]
ADSL1 | adenylosuccinate lyase | [c] : dcamp --> amp + fum |  | RHE_CH02273 | PurB | [NAME]
3AIBT | [NAME] transaminase | [c] : glu-L + mmtsa <==> 3aib + akg |  | RHE_PF00434 | [NAME] | EC-2.6.1.22
HCO3E | HCO3 equilibration reaction | [c] : co2 + h2o <==> h + hco3 |  |  |  | EC-4.2.1.1
MALt2_2 | Malate transport via proton symport (2 H) | (2) h[e] + mal-L[e] --> (2) h[c] + mal-L[c] |  | RHE_CH02971 | DctA
FRNDPRR | [NAME] : nadp reductase | [c] : (2) fdred + h + nadp <==> (2) [NAME] |  | RHE_CH02078 | Fpr | EC-1.18.1.2
[NAME] | glutathione peridoxase | [c] : (2) [NAME] <==> gthox + (2) h2o |  | RHE_CH01597 | BtuE | EC-1.11.1.9
NH3e | Ammonium dissociation, extracellular | [e] : nh4 <==> h + nh3
SUCCt2_2 | succinate transport via proton symport (2 H) | (2) h[e] + succ[e] --> (2) h[c] + succ[c] |  | RHE_CH02971 | DctA
TMDPP | thymidine phosphorylase | [c] : pi + thymd <==> 2dr1p + thym |  | RHE_CH00194 | DeoA | EC-2.4.2.4
ASPt2r | L-aspartate reversible transport via proton symport | asp-L[e] + h[e] <==> asp-L[c] + h[c]
THD2 | NAD(P) transhydrogenase | (2) h[e] + nadh[c] + nadp[c] --> (2) h[c] + nad[c] + nadph[c] |  | RHE_CH03611, RHE_CH03613, RHE_CH03612 | PntB+PntA2+PntA1 | [NAME],
PRMICIi | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (irreversible) | [c] : prfp --> prlp |  | RHE_CH00043 | [NAME] | EC-5.3.1.16
ARGSS | argininosuccinate synthase | [c] : asp-L + atp + citr-L --> amp + argsuc + h + ppi |  | RHE_CH03924 | ArgG2 | EC-6.3.4.5
H2Ot | H2O transport via diffusion | h2o[e] <==> h2o[c] |  | RHE_PD00339 | Ypd00054
METACH | O-Acetyl-L-homoserine acetate-lyase (adding methanethiol) | [c] : achms + h2s <==> ac + h + hcys-L |  | RHE_CH01577 | Ypch00547 | EC-4.2.99.10
ALAt2r | L-alanine reversible transport via proton symport | ala-L[e] + h[e] <==> ala-L[c] + h[c]
PPA | inorganic diphosphatase | [c] : h2o + ppi --> h + (2) pi |  |  |  | EC-3.6.1.1
NH3c | Ammomnium proton dissociation | [c] : h + nh3 <==> nh4
HSTPTr | histidinol-phosphate transaminase reversible | [c] : glu-L + imacp <==> akg + hisp |  | RHE_PD00233, RHE_CH01331, RHE_CH04010, RHE_CH03810 | HisCd+HisCch1+HisCch3+HisCch2 | EC-2.6.1.9
ATPM | ATP maintenance requirement | [c] : atp + h2o --> adp + h + pi | ATP maintenance
ASPTRS | Aspartyl-tRNA synthetase | [c] : asp-L + atp + trnaasp --> amp + asptrna + ppi | [NAME] Metabolism | RHE_CH01497 | AspS | EC-6.1.1.12
ASPR | Aspartate racemase | [c] : asp-D <==> asp-L | [NAME] Metabolism | RHE_CH02763 | Ypch00952 | EC-5.1.1.13
ARGSL | argininosuccinate lyase | [c] : argsuc <==> arg-L + fum | [NAME] Metabolism | RHE_CH03796 | ArgH | EC-4.3.2.1
ASPT_rev | L-aspartase | [c] : asp-L <==> fum + nh4 | Alanine and Aspartate Metabolism | RHE_PE00351 | AnsB | EC-4.3.1.1
ASNS1_r | asparagine synthase (glutamine-hydrolysing) | [c] : asp-L + atp + gln-L + h2o <==> amp + asn-L + glu-L + h + ppi | Alanine and Aspartate Metabolism | RHE_CH00758 | AsnB | EC-6.3.5.4
ALATRS | Alanyl-tRNA synthetase | [c] : ala-L + atp + trnaala --> alatrna + amp + ppi | Alanine and Aspartate Metabolism | RHE_CH02322 | AlaS2 | EC-6.1.1.7
ASPCT | aspartate carbamoyltransferase | [c] : asp-L + cbp --> cbasp + h + pi | Alanine and Aspartate Metabolism | RHE_CH01642 | PyrB | EC-2.1.3.2
ADSS | adenylosuccinate synthase | [c] : asp-L + gtp + imp --> dcamp + gdp + (2) h + pi | Alanine and Aspartate Metabolism | RHE_CH03344 | PurA | [NAME]
ALAR | alanine racemase | [c] : ala-L <==> ala-D | Alanine and Aspartate Metabolism | RHE_PF00437, RHE_CH01432 | DadX+Alr | EC-5.1.1.1
[NAME] | aspartate transaminase | [c] : akg + asp-L <==> glu-L + oaa | Alanine and Aspartate Metabolism | RHE_PC00186, RHE_CH00568, RHE_CH01873, RHE_CH02998, RHE_PF00273 | AatAc+AspB1+AspB2+AatAch+Ypf00130 | EC-2.6.1.1
PHETRS | Phenylalanyl-tRNA synthetase | [c] : atp + phe-L + trnaphe --> amp + phetrna + ppi | Aminoacyl-tRNA biosynthesis | RHE_CH00264, RHE_CH00263 | PheT+PheS | EC-6.1.1.20
TYRTRS | tyrosyl-tRNA synthetase | [c] : atp + trnatyr + tyr-L --> amp + ppi + tyrtrna | Aminoacyl-tRNA biosynthesis | RHE_CH02258 | TyrS | EC-6.1.1.1
ARGTRS | [NAME]-tRNA synthetase | [c] : arg-L + atp + trnaarg --> amp + argtrna + ppi | Aminoacyl-tRNA biosynthesis | RHE_CH01818 | ArgS | EC-6.1.1.19
TRPTRS | Tryptophanyl-tRNA synthetase | [c] : atp + trnatrp + trp-L --> amp + ppi + trptrna | Aminoacyl-tRNA biosynthesis | RHE_CH00383 | TrpS | EC-6.1.1.2
HISTRS | Histidyl-tRNA synthetase | [c] : atp + his-L + trnahis --> amp + histrna + ppi | Aminoacyl-tRNA biosynthesis | RHE_CH00821 | HisS | EC-6.1.1.21
CYSTRS | Cysteinyl-tRNA synthetase | [c] : atp + cys-L + trnacys --> amp + cystrna + ppi | Aminoacyl-tRNA biosynthesis | RHE_CH01425 | CysS | EC-6.1.1.16
ORNDC | Ornithine Decarboxylase | [c] : h + orn --> co2 + ptrc | Arginine and Proline Metabolism | RHE_CH03629 | Ypch01283 | EC-4.1.1.17
ORNCD | ornithine cyclodeaminase | [c] : orn --> nh4 + pro-L | Arginine and Proline Metabolism | RHE_CH00058, [NAME], RHE_CH02026 | Ocdch1+Ocdf+Ocdch2 | EC-4.3.1.12
CBMKr | Carbamate kinase | [c] : atp + co2 + nh4 <==> adp + cbp + (2) h | Arginine and Proline Metabolism |  |  | EC-2.7.2.2
ARGDr | arginine deiminase | [c] : arg-L + h2o <==> citr-L + nh4 | Arginine and Proline Metabolism |  |  | EC-3.5.3.6
AMPTASEPG | aminopeptidase (pro-gly) | [c] : h2o + progly --> gly + pro-L | Arginine and Proline Metabolism | RHE_PB00090, RHE_CH01420, RHE_CH02208 | Pipb2+Pipch1+Pipch2 | EC-3.4.11.2
AGMT | agmatinase | [c] : agm + h2o --> ptrc + urea | Arginine and Proline Metabolism | RHE_CH02143, RHE_CH01568 | SpeB2+SpeB1 | EC-3.5.3.11
PROL_RA | proline racemase | [c] : pro-L --> pro-D | Arginine and Proline Metabolism | RHE_PF00391 | Ypf00209
ASDH | aspartate dehydrogenase | [c] : h + nadh + nh4 + oaa --> asp-L + h2o + nad | Aspartate metabolism
FUM | fumarase | [c] : fum + h2o <==> mal-L | Citric Acid Cycle | [NAME], RHE_CH02383 | FumB, FumC | EC-4.2.1.2
SUCOAS | succinyl-CoA synthetase (ADP-forming) | [c] : atp + coa + succ <==> adp + pi + succoa | Citric Acid Cycle | RHE_CH03890, RHE_CH03889 | SucC, SucD | EC-6.2.1.5
CS | citrate synthase | [c] : accoa + h2o + oaa --> cit + coa + h | Citric Acid Cycle | RHE_CH02183, RHE_CH01926 | Ypch00716, GltA
ACONTb | aconitase (half-reaction B, Isocitrate hydro-lyase) | [c] : acon-C + h2o <==> icit | Citric Acid Cycle | RHE_CH03944 | AcnA | EC-4.2.1.3
SUCD1 | succinate dehydrogenase | [c] : fad + succ <==> fadh2 + fum | Citric Acid Cycle | RHE_CH03896, RHE_CH03897, [NAME], RHE_CH03895 | SdhD+SdhC+SdhB+SdhA | [NAME]
OORr | 2-oxoglutarate synthase (reversible) | [c] : akg + coa + (2) fdox <==> co2 + (2) fdred + h + succoa | Citric Acid Cycle | RHE_CH03888 | SucA | EC-1.2.7.3
ICDHx | isocitrate dehydrogenase (NAD) | [c] : icit + nad <==> akg + co2 + nadh | Citric Acid Cycle | RHE_CH02318 | Icd | EC-1.1.1.41
ACONTa | aconitase (half-reaction A, Citrate hydro-lyase) | [c] : cit <==> acon-C + h2o | Citric Acid Cycle | RHE_CH03944 | AcnA | EC-4.2.1.3
AKGDH | 2-Oxogluterate dehydrogenase | [c] : akg + coa + nad --> co2 + nadh + succoa | Citric Acid Cycle |  |  | EC-Undetermined
EDA | 2-dehydro-3-deoxy-phosphogluconate aldolase | [c] : 2ddg6p --> g3p + pyr | Entner-Doudoroff pathwway | RHE_CH03635 | Eda | EC-4.1.2.14
EDD | 6-phosphogluconate dehydratase | [c] : 6pgc --> 2ddg6p + h2o | Entner-Doudoroff pathwway | RHE_CH00702 | Edd | EC-4.2.1.12
AMCPC | aminocyclopropanecarboxylate oxidase | [c] : 1acpr1cx + ascb-L + o2 --> co2 + cyan + dhdascb + ethy + (2) h2o | Ethylene metabolism
ECOAH1 | 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) | [c] : 3hbcoa <==> b2coa + h2o | Fatty Acid Metabolism | RHE_CH00906, RHE_CH00559, [NAME], [NAME], RHE_PF00542, RHE_CH01573, RHE_CH00356 | Ypch00296+FadB2+Ypch00578+Ypch00209+Ypf00266+Ypch00545+FadB1 | EC-4.2.1.17
FACOAL160 | fatty-acid--CoA ligase (hexadecanoate) | [c] : atp + coa + hdca <==> amp + pmtcoa + ppi | Fatty Acid Metabolism | RHE_CH00478, RHE_CH00921, RHE_PF00013 | FadD+MatB+Ypf00005 | EC-6.2.1.3
HACD1 | 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) | [c] : aacoa + h + nadh <==> 3hbcoa + nad | Fatty Acid Metabolism | RHE_PC00126, RHE_CH00559, RHE_CH03794, RHE_PC00067 | Ypc00064+FadB2+HbdA+Ypc00039 | EC-1.1.1.35
FA05 | Fatty acids oxidation | [c] : atp + (10) coa + eico + (9) fad + (9) h2o + (9) nad --> (10) accoa + amp + (9) fadh2 + (9) h + (9) nadh + ppi | Fatty Acid Oxidation
FAO3 | Fatty acid oxidation (octadecanoate) | [c] : atp + (9) coa + (8) fad + (8) h2o + (8) nad + ocdca --> (9) accoa + amp + (8) fadh2 + (8) h + (8) nadh + ppi | Fatty Acid Oxidation
FAO2 | Fatty acid oxidation (n-C16:0) | [c] : atp + (8) coa + (7) fad + (7) h2o + hdca + (7) nad --> (8) accoa + amp + (7) fadh2 + (7) h + (7) nadh + ppi | Fatty acid oxidation
[NAME] | Fatty acid oxidation | [c] : atp + (7) coa + (7) fad + (8) h2o + hpdca + (7) nad --> (7) accoa + amp + (7) fadh2 + (8) h + (7) nadh + ppa + ppi | Fatty acid oxidation
GLUCYS | gamma-glutamylcysteine synthetase | [c] : atp + cys-L + glu-L --> adp + glucys + h + pi | Glutamate Metabolism | RHE_CH00803 | Gsh | EC-6.3.2.2
GLUR | glutamate racemase | [c] : glu-D <==> [NAME] | Glutamate Metabolism | RHE_CH02314 | MurI | EC-5.1.1.3
GLUTRS | Glutamyl-tRNA synthetase | [c] : atp + glu-L + trnaglu --> amp + glutrna + ppi | Glutamate Metabolism | RHE_CH03656 | GltX1 | EC-6.1.1.17
GTHOr | glutathione oxidoreductase | [c] : gthox + h + nadph <==> (2) [NAME] | Glutamate Metabolism | RHE_CH02377 | Gor | EC-1.8.1.7
CBPS | carbamoyl-phosphate synthase (glutamine-hydrolysing) | [c] : (2) atp + gln-L + h2o + hco3 --> (2) adp + cbp + glu-L + (2) h + pi | Glutamate metabolism | RHE_CH02966, RHE_CH02957 | CarB, CarA | [NAME]
[NAME] | glutamine-fructose-6-phosphate transaminase | [c] : f6p + gln-L --> gam6p + glu-L | Glutamate metabolism | RHE_CH02091, RHE_CH04036 | [NAME] | EC-2.6.1.16
GTHS | glutathione synthetase | [c] : atp + glucys + gly --> adp + gthrd + h + pi | Glutamate metabolism | RHE_CH00322 | GshB | EC-6.3.2.3
GPAT_Rhizobium | glutamine-pyruvate aminotransferase | [c] : gln-L + h + pyr <==> 2oxgltrm + ala-L | Glutamate/Nitrogen Metabolism |  |  | EC-2.6.1.15
GLUN | glutaminase | [c] : gln-L + h2o --> glu-L + nh4 | Glutamate/Nitrogen Metabolism | RHE_CH02311 | GAM | EC-3.5.1.2
AMID6 | amidase | [c] : 2oxgltrm + h2o --> akg + h + nh4 | Glutamate/Nitrogen Metabolism |  |  | EC-3.5.1.4
ABTA | 4-aminobutyrate transaminase | [c] : 4abut + akg --> glu-L + sucsal | Glutamate/Nitrogen Metabolism | RHE_CH00093 | GabT | EC-2.6.1.19
GLNS | glutamine synthetase | [c] : atp + glu-L + nh4 --> adp + gln-L + h + pi | Glutamate/Nitrogen Metabolism | RHE_PE00418, RHE_CH03104, RHE_CH02102, RHE_CH00706, RHE_CH02886, RHE_CH01315 | GlnT+GlnII+GlnA2+GlnA1+GlnA3+Ypch00448 | EC-6.3.1.2
SSALy | succinate-semialdehyde dehydrogenase (NADP) | [c] : h2o + nadp + sucsal --> (2) h + nadph + succ | Glutamate/Nitrogen Metabolism | RHE_CH00092, RHE_PF00201, RHE_PC00032, RHE_PF00340, RHE_PF00364 | GabDch+Ypf00097+GabDc+GabDf1+GabDf2 | EC-1.2.1.16
GLUDC | Glutamate Decarboxylase | [c] : glu-L + h --> 4abut + co2 | Glutamate/Nitrogen Metabolism |  |  | EC-4.1.1.15
GLUSy | glutamate synthase (NADPH) | [c] : akg + gln-L + h + nadph --> (2) [NAME] | Glutamate/Nitrogen Metabolism |  |  | EC-1.4.1.13
GTr_Retli | glutamine-glyoxylate Transaminase | [c] : gln-L + glx + h <==> 2oxgltrm + gly | Glutamine degradation
AMPTASECG | alanyl aminopeptidase (cys-gly) | [c] : cgly + h2o --> cys-L + gly | Glutathione Metabolism | RHE_CH01298 | PepN | EC-3.4.11.2
GTMLT | g-glutamyltransferase | [c] : ala-L + gthrd --> cgly + gluala | Glutathione Metabolism | RHE_CH03536, RHE_CH02146 | Ggt2+Ggt1 | EC-2.3.2.2
PGCDr | phosphoglycerate dehydrogenase reversible | [c] : 3pg + nad <==> 3php + h + nadh | Glycine and Serine Metabolism | RHE_CH03454, RHE_PF00379 | SerA+Ypf00200 | EC-1.1.1.95
SERD_Lr | L-serine deaminase (rev) | [c] : ser-L <==> nh4 + pyr | Glycine and Serine Metabolism | RHE_CH02214, RHE_PF00182, RHE_CH04092, RHE_CH02027, [NAME], RHE_CH03537 | Sda, [NAME], [NAME], Ypch00645, IlvA, Ypch01250 | EC-4.3.1.17
PSSYNi | CDP-diacylglycerol-serine O-phosphatidyltransferase | [c] : cdpdag + ser-L --> cmp + (2) h + ps | Glycine, Serine, and Threonine Metabolism | RHE_CH01410 | PssA1 | EC-2.7.8.8
HSDy | homoserine dehydrogenase (NADPH) | [c] : hom-L + nadp <==> aspsa + h + nadph | Glycine, Serine, and Threonine Metabolism | RHE_CH01878 | Thra | EC-1.1.1.3
ASADi | aspartate-semialdehyde dehydrogenase, irreversible | [c] : 4pasp + h + nadph --> aspsa + nadp + pi | Glycine, Serine, and Threonine Metabolism | RHE_CH04100 | Asd | EC-1.2.1.11
THRD_L | L-threonine deaminase | [c] : [NAME] --> 2obut + nh4 | Glycine, Serine, and Threonine Metabolism | RHE_CH01759, RHE_CH04092, RHE_PF00182, RHE_CH03537, RHE_CH02027 | IlvA, [NAME], [NAME], Ypch01250, Ypch00645 | EC-4.3.1.19
SERTRS | [NAME]-tRNA synthetase | [c] : atp + ser-L + trnaser --> amp + ppi + sertrna | Glycine, Serine, and Threonine Metabolism | RHE_CH01826, RHE_CH04045 | SerS+Ypch01429 | EC-6.1.1.11
THRTRS | Threonyl-tRNA synthetase | [c] : atp + thr-L + trnathr --> amp + ppi + thrtrna | Glycine, Serine, and Threonine Metabolism | RHE_CH02196 | ThrS | EC-6.1.1.3
PSERTr | phosphoserine transaminase reversible | [c] : 3php + glu-L <==> akg + pser-L | Glycine, Serine, and Threonine Metabolism | RHE_CH03455 | SerC | EC-2.6.1.52
PSD-Rhizobium | phosphatidylserine decarboxylase | [c] : h + ps --> co2 + pe | Glycine, Serine, and Threonine Metabolism | RHE_CH01411 | Psd | EC-4.1.1.65
CYSTS | cystathionine beta-synthase | [c] : hcys-L + ser-L --> cyst-L + h2o | Glycine, Serine, and Threonine Metabolism | RHE_CH01775 | CysK2 | EC-4.2.1.22
HSK | [NAME] | [c] : atp + hom-L --> adp + h + phom | Glycine, Serine, and Threonine Metabolism | RHE_CH00962 | ThrB | EC-2.7.1.39
THRA2r | L-allo-Threonine Aldolase | [c] : athr-L <==> acald + gly | Glycine, Serine, and Threonine Metabolism | RHE_CH03568 | Ypch01258 | EC-4.1.2.5
THRS | threonine synthase | [c] : h2o + phom --> pi + thr-L | Glycine, Serine, and Threonine Metabolism | RHE_CH00979, RHE_CH04092 | ThrC, [NAME] | EC-4.2.3.1
THRD | L-threonine dehydrogenase | [c] : [NAME] --> 2aobut + h + nadh | Glycine, Serine, and Threonine Metabolism | RHE_CH02951 | Tdh | EC-1.1.1.103
THRAr | [NAME] | [c] : thr-L <==> acald + gly | Glycine, Serine, and Threonine Metabolism | RHE_CH03568 | Ypch01258 | EC-4.1.2.5
GHMT2 | glycine hydroxymethyltransferase | [c] : ser-L + thf --> gly + h2o + mlthf | Glycine, Serine, and Threonine Metabolism | RHE_CH01508 | GlyA | EC-2.1.2.1
ALAS | 5-aminolevulinate synthase | [c] : gly + h + succoa --> 5aop + co2 + coa | Glycine, Serine, and Threonine Metabolism | RHE_PF00489 | HemAf | EC-2.3.1.37
GLYAT | glycine C-acetyltransferase | [c] : accoa + gly <==> 2aobut + coa | Glycine, Serine, and Threonine Metabolism | RHE_PF00489, RHE_CH02952 | HemAf, [NAME] | EC-2.3.1.29
ASPKi | aspartate kinase, irreversible | [c] : asp-L + atp --> 4pasp + adp | Glycine, Serine, and Threonine Metabolism | RHE_CH03758 | [NAME] | EC-2.7.2.4
PSP_L | phosphoserine phosphatase (L-serine) | [c] : h2o + pser-L --> pi + ser-L | Glycine, Serine, and Threonine Metabolism | RHE_CH02794 | SerB | EC-3.1.3.3
GLYTRS | [NAME]-tRNA synthetase | [c] : atp + gly + trnagly --> amp + glytrna + ppi | Glycine, Serine, and Threonine Metabolism | RHE_CH00890 | [NAME] | EC-6.1.1.14
GLCS1 | glycogen synthase (ADPGlc) | [c] : adpglc --> adp + glycogen + h | [NAME] synthesis | RHE_CH03596 | GlgA | EC-2.4.1.21
[NAME] | glucose-1-phosphate adenylyltransferase | [c] : atp + g1p + h --> adpglc + ppi | [NAME] synthesis | RHE_CH03595 | GlgC | EC-2.7.7.27
PYK | pyruvate kinase | [c] : adp + h + pep --> atp + pyr | Glycolysis | RHE_CH03542 | PykA | EC-2.7.1.40
PFK | phosphofructokinase | [c] : atp + f6p --> adp + fdp + h | Glycolysis | RHE_CH02862 | Pfk | EC-2.7.1.11
FBP | fructose-bisphosphatase | [c] : fdp + h2o --> f6p + pi | Glycolysis/Gluconeogenesis |  |  | EC-3.1.3.11
GAPD | glyceraldehyde-3-phosphate dehydrogenase | [c] : [NAME] <==> 13dpg + h + nadh | Glycolysis/Gluconeogenesis | RHE_CH03496 | Gap | EC-1.2.1.12
PGI | glucose-6-phosphate isomerase | [c] : g6p <==> f6p | Glycolysis/Gluconeogenesis | RHE_CH00477 | Pgi | EC-5.3.1.9
PGM | phosphoglycerate mutase | [c] : 2pg <==> 3pg | Glycolysis/Gluconeogenesis | RHE_CH00169 | GpmA | EC-5.4.2.1
PGK | phosphoglycerate kinase | [c] : 3pg + atp <==> 13dpg + adp | Glycolysis/Gluconeogenesis | RHE_CH03499 | Pgk | EC-2.7.2.3
PPCK | phosphoenolpyruvate carboxykinase | [c] : atp + oaa --> adp + co2 + pep | Glycolysis/Gluconeogenesis | RHE_CH00037 | PckA | EC-4.1.1.49
PGMT | phosphoglucomutase | [c] : g1p <==> g6p | Glycolysis/Gluconeogenesis | RHE_CH03597 | Pgm | EC-5.4.2.2
ENO | enolase | [c] : 2pg <==> h2o + pep | Glycolysis/Gluconeogenesis | RHE_CH01931 | Eno | EC-4.2.1.11
FBA | fructose-bisphosphate aldolase | [c] : fdp <==> dhap + g3p | Glycolysis/Gluconeogenesis | RHE_CH03500 | FbaB | EC-4.1.2.13
PC | pyruvate carboxylase | [c] : atp + hco3 + pyr --> adp + h + oaa + pi | Glycolysis/Gluconeogenesis | [NAME] | Pyc | EC-6.4.1.1
ICL | Isocitrate lyase | [c] : icit --> glx + succ | Glycoxylate Metabolism | RHE_CH00712 | AceA | EC-4.1.3.1
MALS | malate synthase | [c] : accoa + glx + h2o --> coa + h + mal-L | Glycoxylate Metabolism |  |  | EC-4.1.3.2
MDH | malate dehydrogenase | [c] : mal-L + nad <==> h + nadh + oaa | Glyoxylate and Dicarboxylate Metabolism | RHE_PF00428, [NAME], RHE_PF00366 | Ypf00228+Mdh+Ypf00191 | EC-1.1.1.37
MALS_rhizobia | malate synthase | [c] : accoa + glx + h2o <==> coa + h + mal-L | Glyoxylate and Dicarboxylate Metabolism | RHE_CH00052 | GlcB | EC-4.1.3.2
IG3PS | Imidazole-glycerol-3-phosphate synthase | [c] : gln-L + prlp --> aicar + eig3p + glu-L + h | Histidine Metabolism
PRATPP | phosphoribosyl-ATP pyrophosphatase | [c] : h2o + prbatp --> h + ppi + prbamp | Histidine Metabolism | RHE_CH00041 | [NAME] | EC-3.6.1.31
HISD | histidase | [c] : his-L --> nh4 + urcan | Histidine Metabolism | RHE_PE00072, RHE_PE00081 | HutHe1+HutHe2 | EC-4.3.1.3
HISTD | histidinol dehydrogenase | [c] : h2o + histd + (2) nad --> (3) h + his-L + (2) nadh | Histidine Metabolism | RHE_CH00581 | HisD | EC-1.1.1.23
ATPPRTr | ATP phosphoribosyltransferase reversible | [c] : atp + prpp <==> ppi + prbatp | Histidine Metabolism | RHE_CH00823 | HisG | EC-2.4.2.17
PRAMPC | phosphoribosyl-AMP cyclohydrolase | [c] : h2o + prbamp --> prfp | Histidine Metabolism | RHE_CH00041, RHE_CH02202 | HisE+HisI | EC-3.5.4.19
IZPN | imidazolonepropionase | [c] : 4izp + h2o --> forglu + h | Histidine Metabolism | RHE_PE00073 | HutI | EC-3.5.2.7
FGLU | formimidoylglutamase | [c] : forglu + h + h2o --> frmd + glu-L | Histidine Metabolism | RHE_PE00071 | HutG | EC-3.5.3.8
URCN | urocanase | [c] : h2o + urcan --> 4izp | Histidine Metabolism | RHE_PE00070 | HutUe | EC-4.2.1.49
HISTP | histidinol-phosphatase | [c] : h2o + hisp --> histd + pi | Histidine Metabolism |  |  | EC-3.1.3.15
IGPDH | imidazoleglycerol-phosphate dehydratase | [c] : eig3p --> h2o + imacp | Histidine Metabolism | RHE_CH00047 | HisB | EC-4.2.1.19
TPI | triose-phosphate isomerase | [c] : dhap <==> [NAME] | Inositol Metabolism | RHE_CH02186, RHE_PF00040 | TpiAch+TpiAf | EC-5.3.1.1
MMSAD3 | methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde) | [c] : coa + msa + nad --> accoa + co2 + nadh | Inositol Metabolism | RHE_CH00731 | IolA | EC-1.2.1.27
INS2D | inositol 2-dehydrogenase | [c] : inost + nad --> 2ins + h + nadh | Inositol Metabolism | RHE_CH03170, RHE_CH01209 | IdhA+Ypch00405 | EC-1.1.1.18
INSCR | inositol catabolic reactions (lumped) | [c] : 2ins + atp --> adp + dhap + (2) h + msa | Inositol Metabolism
DHDPRy | dihydrodipicolinate reductase (NADPH) | [c] : 23dhdp + h + nadph --> nadp + thdp | Lysine Biosynthesis |  |  | EC-1.3.1.26
DHDPRx | dihydrodipicolinate reductase (NADH) | [c] : 23dhdp + h + nadh --> nad + thdp | Lysine Biosynthesis |  |  | EC-1.3.1.26
DAPDC | diaminopimelate decarboxylase | [c] : 26dap-M + h --> co2 + lys-L | Lysine Biosynthesis | RHE_CH03797 | IysA | EC-4.1.1.20
UAAGDS | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase | [c] : 26dap-M + atp + uamag --> adp + h + pi + ugmd | Lysine Biosynthesis | RHE_CH02852 | MurE | EC-6.3.2.13
UGMDDS | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase | [c] : alaala + atp + ugmd --> adp + h + pi + ugmda | Lysine Biosynthesis | RHE_CH02851 | MurF | EC-6.3.2.15
DHDPS | dihydrodipicolinate synthase | [c] : aspsa + pyr --> 23dhdp + h + (2) h2o | Lysine Metabolism | RHE_PF00398, RHE_PC00042, [NAME], RHE_CH00606, RHE_CH01381, RHE_CH02792 | DapAf3, Ypc00025, DapAf1, DapAch1, DapAch2, DapAch3 | EC-4.2.1.52
[NAME] | tetrahydrodipicolinate succinylase | [c] : h2o + succoa + thdp --> coa + sl2a6o | Lysine Metabolism | RHE_CH00418 | DapD | EC-2.3.1.117
SDPTA | succinyldiaminopimelate transaminase | [c] : akg + sl26da <==> [NAME] sl2a6o | Lysine Metabolism | RHE_PD00118, RHE_CH01877 | AatCD+AatCch | EC-2.6.1.17
DAPE | diaminopimelate epimerase | [c] : 26dap-LL <==> 26dap-M | Lysine Metabolism | RHE_CH03955 | DapF | EC-5.1.1.7
LYSTRS | Lysyl-tRNA synthetase | [c] : atp + lys-L + trnalys --> amp + lystrna + ppi | Lysine Metabolism | RHE_CH03657, RHE_CH04041 | IysS+GenX | EC-6.1.1.6
SDPDS | succinyl-diaminopimelate desuccinylase | [c] : h2o + sl26da --> 26dap-LL + succ | Lysine Metabolism | RHE_CH00417 | DapE2 | EC-3.5.1.18
METTRS | Methionyl-tRNA synthetase | [c] : atp + met-L + trnamet --> amp + mettrna + ppi | [NAME] | RHE_CH02157, RHE_CH03014, RHE_PD00315 | MetS, CsaA, Ypd00050 | EC-6.1.1.10
AHC | adenosylhomocysteinase | [c] : ahcys + h2o <==> adn + hcys-L | [NAME] | RHE_CH00031 | AhcY | [NAME]
METS | methionine synthase | [c] : 5mthf + hcys-L --> h + met-L + thf | [NAME] | RHE_CH02901 | MetH | EC-2.1.1.13
[NAME] | [NAME] (rev) | [c] : achms + cys-L <==> ac + cyst-L + h | [NAME] | RHE_PF00019, RHE_PE00244, RHE_PF00461, RHE_CH00522 | MdeAf, MdeAe, VbsL, MetZ | EC-4.2.99.9
SSHy_Rhizobium | L-Serine hydro-lyase (adding homocysteine) | [c] : h + hs- + ser-L --> cys-L + h2o | [NAME] | RHE_CH01775 | CysK2 | EC-4.2.1.22
METAT | methionine adenosyltransferase | [c] : atp + h2o + met-L --> amet + pi + ppi | [NAME] | RHE_CH00370 | MetK | EC-2.5.1.6
FMETTRS | Methionyl-tRNA formyltransferase | [c] : 10fthf + mettrna --> fmettrna + h + thf | [NAME] | RHE_CH00414 | Fmt | EC-2.1.2.9
HSST | homoserine O-succinyltransferase | [c] : hom-L + succoa --> coa + suchms | [NAME] | RHE_CH04033 | MetA | EC-2.3.1.46
AHCYSNS | S-adenosylhomocysteine nucleosidase | [c] : ahcys + h2o --> ade + rhcys | [NAME] | RHE_CH00298 | Pfs | EC-3.2.2.9
SHSL1 | O-succinylhomoserine lyase (L-cysteine) | [c] : cys-L + suchms --> cyst-L + h + succ | [NAME] | RHE_PE00244, [NAME], RHE_CH00522, [NAME], RHE_PF00461, RHE_PE00244, RHE_PF00461 | MdeAe, [NAME], MetZ+MdeAf+VbsL+MdeAe, VbsL | EC-4.2.99.9
SHSL4r | O-succinylhomoserine lyase (elimination), reversible | [c] : h2o + suchms <==> 2obut + h + nh4 + succ | [NAME] | RHE_CH00522, RHE_PE00244, RHE_PF00461, RHE_PF00019 | MetZ, MdeAe, VbsL, [NAME] | EC-4.2.99.9
HCYSMT | homocysteine S-methyltransferase | [c] : amet + hcys-L --> ahcys + h + met-L | [NAME] | RHE_PC00163 | Ypc00089 | EC-2.1.1.10
DNAMTn2 | DNA (cytosine-5-)-methyltransferase | [c] : amet + dna --> ahcys + dna5mtc + h | [NAME] | RHE_PF00108 | Ypf00052 | EC-2.1.1.37
[NAME] | O-Succinyl-L-homoserine succinate-lyase (adding cysteine) | [c] : hs- + suchms <==> hcys-L + succ | [NAME] | RHE_CH00522, [NAME], RHE_PE00244, RHE_PF00461 | MetZ, [NAME], MdeAe, VbsL
CYSTL | [NAME] | [c] : cyst-L + h2o --> hcys-L + nh4 + pyr | [NAME] | RHE_CH01899 | MetC | EC-4.4.1.8
NAPRTr | NAPRTase (rev) | [c] : h + nac + prpp <==> nicrnt + ppi | Nicotinate and Nicotinamide | RHE_CH00181 | PncB | EC-2.4.2.11
NNATr | nicotinate-nucleotide adenylyltransferase | [c] : atp + h + nicrnt <==> dnad + ppi | Nicotinate and Nicotinamide | RHE_CH04070 | NadD | EC-2.7.7.18
NADS2 | NAD synthase (glutamine-hydrolysing) | [c] : atp + dnad + gln-L + h2o --> amp + glu-L + h + nad + ppi | Nicotinate and Nicotinamide | RHE_CH01195, RHE_CH02371 | Ypch00397+NadE | EC-6.3.5.1
NT5C | 5'-nucleotidase | [c] : h2o + nicrnt --> nicrns + pi | Nicotinate and Nicotinamide | RHE_CH03555 | [NAME] | EC-3.1.3.5
NTD5_a | 5'-nucleotidase (dTMP) | [c] : h2o + nmn --> pi + rnam | Nicotinate and Nicotinamide | RHE_CH03555 | [NAME] | EC-3.1.3.5
NADTRHD | NAD transhydrogenase | [c] : nad + nadph --> nadh + nadp | Nicotinate and Nicotinamide | RHE_CH01846, RHE_CH01651 | Ypch00610, [NAME] | EC-Undetermined
NP1_r | nucleotide phosphatase | [c] : h + nac + r1p <==> nicrns + pi | Nicotinate and Nicotinamide | RHE_CH00192 | DeoD | EC-2.4.2.1
NNAM | nicotinamidase | [c] : h2o + ncam --> nac + nh4 | Nicotinate and Nicotinamide | RHE_CH02821 | PncA | EC-3.5.1.19
PNP | purine-nucleoside phosphorylase | [c] : pi + rnam <==> h + ncam + r1p | Nicotinate and Nicotinamide | RHE_CH00192 | DeoD | EC-2.4.2.1
[NAME] | nicotinate-nucleotide diphosphorylase (carboxylating) | [c] : (2) h + prpp + quln --> co2 + nicrnt + ppi | Nicotinate and Nicotinamide | RHE_PE00439 | NadC | EC-2.4.2.19
NMNATr | nicotinamide-nucleotide adenylyltransferase | [c] : atp + h + nmn <==> [NAME] | Nicotinate and Nicotinamide | RHE_CH04070 | NadD | EC-2.7.7.1
NMNN | NMN nucleosidase | [c] : h2o + nmn --> h + ncam + r5p | Nicotinate and Nicotinamide | RHE_CH02485 | IunH2 | EC-3.2.2.14
NIT | nitrogenase | [c] : (16) atp + (6) fdred + (16) h2o + n2 --> (16) adp + (6) [NAME]8) h + (2) nh4 + (16) pi | Nitrogen Metabolism | RHE_PD00201, RHE_PD00307, RHE_PD00306, RHE_PD00202, RHE_PD00200, RHE_PD00260, RHE_PD00308 | NifD3+NifD1+NifK1+NifH3+NifK2+NifH2+NifH1 | EC-1.18.6.1
CYTOX | Cytochrome oxidase | (4) h[c] + o2[c] + (2) qh2[c] --> (4) h[e] + (2) h2o[c] + (2) q[c] | Oxidative Phosphorylation |  |  | EC-Undetermined, TC-Undetermined
SUCD3 | succinate dehydrogenase cytochrome b | [c] : fadh2 + q <==> fad + qh2 | Oxidative Phosphorylation
ATPS2 | ATP synthase (two protons for one ATP) | adp[c] + (2) h[e] + pi[c] --> atp[c] + h[c] + h2o[c] | Oxidative Phosphorylation |  |  | EC-3.6.3.14,
[NAME] | Cytochrome oxidase (rhizobium) | (2) h[c] + o2[c] + (2) qh2[c] --> (2) h[e] + (2) h2o[c] + (2) q[c] | Oxidative Phosphorylation |  |  | EC-Undetermined, TC-Undetermined
NADH (Rhizobium) | NADH dehydrogenase | (5) h[c] + nadh[c] + q[c] --> (4) h[e] + nad[c] + qh2[c] | Oxidative Phosphorylation |  |  | EC-Undetermined, TC-Undetermined
PHBS | PHB synthase | [c] : 3hbcoa-R --> coa + phb | PHB synthesis
ACACT1r | acetyl-CoA C-acetyltransferase | [c] : (2) accoa <==> aacoa + coa | PHB synthesis | RHE_CH00558, RHE_PE00203, RHE_CH04018, RHE_PF00014 | FadA+PcaF, PhbAch, PhbAf | EC-2.3.1.9
PHB_deg_1 | PHB depolymerase | [c] : h2o + (2) phb --> 3hbb-RR + h | PHB synthesis
PHPB | acetoacetyl-CoA reductase | [c] : aacoa + h + nadph <==> 3hbcoa-R + nadp | PHB synthesis | RHE_CH04019 | PhbB | EC-1.1.1.36
[NAME] | hydroxybutyrate-dimer hydrolase; | [c] : 3hbb-RR + h2o <==> (2) bhb + h | PHB synthesis
AACOAT_1 | acetoacetyl-CoA synthetase | [c] : acac + atp + coa --> aacoa + amp + ppi | PHB synthesis | RHE_CH00719 | AcsA1
BDH | (R)-3-Hydroxybutanoate:NAD+ oxidoreductase | [c] : bhb + nad <==> acac + h + nadh | PHB synthesis | RHE_CH03123 | BdhA | EC-1.1.1.30
OCOAT1r | 3-oxoacid CoA-transferase | [c] : acac + succoa <==> aacoa + succ | PHB synthesis | RHE_PE00202, RHE_PE00201 | PcaJ+PcaI | EC-2.8.3.5
PANTS | pantothenate synthase | [c] : ala-B + atp + pant-R --> amp + h + pnto-R + ppi | Pantothenate and CoA Biosynthesis | RHE_PF00001 | PanC | EC-6.3.2.1
PPCDC | phosphopantothenoylcysteine decarboxylase | [c] : 4ppcys + h --> co2 + pan4p | Pantothenate and CoA Biosynthesis | RHE_CH00342 | Dfp | EC-4.1.1.36
PTPAT | pantetheine-phosphate adenylyltransferase | [c] : atp + h + pan4p <==> dpcoa + ppi | Pantothenate and CoA Biosynthesis | RHE_CH02113 | CoaD | EC-2.7.7.3
ACPpds | [acyl-carrier-protein] phosphodiesterase | [c] : ACP + h2o --> apoACP + h + pan4p | Pantothenate and CoA Biosynthesis | RHE_PC00047, RHE_CH01764 | Ypc00027+AcpD | EC-3.1.4.14
PNCDC | pantothenoylcysteine decarboxylase | [c] : h + ptcys --> co2 + ptth | Pantothenate and CoA Biosynthesis | RHE_CH00040 | [NAME] | EC-2.7.1.33
MOHMT | 3-methyl-2-oxobutanoate hydroxymethyltransferase | [c] : 3mob + h2o + mlthf --> 2dhp + thf | Pantothenate and CoA Biosynthesis | RHE_PF00002, RHE_PE00443 | PanB+Ype00224 | EC-2.1.2.11
PTHK | pantetheine kinase | [c] : atp + ptth --> adp + h + pan4p | Pantothenate and CoA Biosynthesis | RHE_CH00040 | [NAME] | EC-2.7.1.34
DPCOAK | dephospho-CoA kinase | [c] : atp + dpcoa --> adp + coa + h | Pantothenate and CoA Biosynthesis | RHE_CH00004 | CoaE | EC-2.7.1.24
PPNCL3 | phosphopantothenate-cysteine ligase | [c] : 4ppan + atp + cys-L --> 4ppcys + amp + h + ppi | Pantothenate and CoA Biosynthesis | RHE_CH00342 | Dfp | EC-6.3.2.5
ACPS1 | acyl-carrier protein synthase | [c] : apoACP + coa --> ACP + h + pap | Pantothenate and CoA Biosynthesis | RHE_CH01388 | AcpS | EC-2.7.8.7
DPR | 2-dehydropantoate 2-reductase | [c] : 2dhp + h + nadph --> nadp + pant-R | Pantothenate and CoA Biosynthesis | RHE_CH01710 | Ypch00569 | EC-1.1.1.169
PNTK | pantothenate kinase | [c] : atp + pnto-R --> 4ppan + adp + h | Pantothenate and CoA Biosynthesis | RHE_CH00040 | [NAME] | EC-2.7.1.33
TKT2 | transketolase | [c] : e4p + xu5p-D <==> f6p + g3p | Pentose Phosphate Pathway | RHE_CH02398, RHE_CH03495, RHE_CH02397 | TktB+Tkt+TktA | EC-2.2.1.1
RBKr | ribokinase reversible | [c] : atp + rib-D <==> adp + h + r5p | Pentose Phosphate Pathway | RHE_PC00098, RHE_CH00409 | Ypc00049, RbsK | EC-2.7.1.15
GND | phosphogluconate dehydrogenase | [c] : 6pgc + nadp --> co2 + nadph + ru5p-D | Pentose Phosphate Pathway | [NAME], RHE_CH02468 | [NAME] | EC-1.1.1.44
TALA | transaldolase | [c] : [NAME] <==> e4p + f6p | Pentose Phosphate Pathway | RHE_CH03667 | Tal | EC-2.2.1.2
TKT1 | transketolase | [c] : r5p + xu5p-D <==> [NAME] | Pentose Phosphate Pathway | RHE_CH02398, RHE_CH03495, RHE_CH02397 | TktB+Tkt+TktA | EC-2.2.1.1
G6PDH2 | glucose 6-phosphate dehydrogenase | [c] : g6p + nadp --> 6pgl + h + nadph | Pentose Phosphate Pathway | RHE_CH01185, RHE_CH00704 | Zwf2, Zwf1 | EC-1.1.1.49
RPE | ribulose 5-phosphate 3-epimerase | [c] : ru5p-D <==> xu5p-D | Pentose Phosphate Pathway | RHE_CH02270 | Rpe | EC-5.1.3.1
RPI | ribose-5-phosphate isomerase | [c] : r5p <==> ru5p-D | Pentose Phosphate Pathway | RHE_CH02380, RHE_PF00039 | RpiA+RpiB | EC-5.3.1.6
PGL | 6-phosphogluconolactonase | [c] : 6pgl + h2o --> 6pgc + h | Pentose Phosphate Pathway | RHE_CH00703 | Pgl | EC-3.1.1.31
[NAME] | anthranilate phosphoribosyltransferase | [c] : anth + prpp --> ppi + pran | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH02174 | [NAME] | EC-2.4.2.18
TRPS3r | tryptophan synthase (indoleglycerol phosphate) | [c] : 3ig3p <==> [NAME] | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH00021 | TrpB | EC-4.2.1.20
IGPS | indole-3-glycerol-phosphate synthase | [c] : 2cpr5p + h --> 3ig3p + co2 + h2o | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH02175 | TrpC | EC-4.1.1.48
DHQD | 3-dehydroquinate dehydratase | [c] : 3dhq <==> 3dhsk + h2o | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH01931, RHE_CH01871, RHE_CH02289 | Eno, AroQ1+AroQ2 | EC-4.2.1.10
ANS | anthranilate synthase | [c] : chor + gln-L --> anth + glu-L + h + pyr | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH03075 | TrpE | [NAME]
PHETHPTOX | L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) | [c] : o2 + phe-L + thbpt --> dhbpt + h2o + tyr-L | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH01742 | PhhA | EC-1.14.16.1
TRPS2 | tryptophan synthase (indole) | [c] : indole + ser-L --> h2o + trp-L | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH00021 | TrpB | EC-4.2.1.20
PPNDHr | prephenate dehydratase | [c] : h + pphn <==> co2 + h2o + phpyr | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH00131 | PheA | EC-4.2.1.51
TRPS1r | tryptophan synthase (indoleglycerol phosphate) | [c] : 3ig3p + ser-L <==> g3p + h2o + trp-L | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH00021 | TrpB | EC-4.2.1.20
PHETA1 | phenylalanine transaminase | [c] : akg + phe-L <==> glu-L + phpyr | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH01331, RHE_CH04010, RHE_CH03810 | HisCch1+HisCch3+HisCch2 | EC-2.6.1.58
PRAI | phosphoribosylanthranilate isomerase | [c] : pran <==> 2cpr5p | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH00020 | TrpF | EC-5.3.1.24
AROH | L-Arogenate hydro-lyase | [c] : Largn --> co2 + h2o + phe-L | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH00131 | PheA | EC-4.2.1.51
TYRTA | [NAME] | [c] : akg + tyr-L <==> 34hpp + glu-L | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH01331, RHE_CH04010, RHE_CH03810, RHE_PC00186, RHE_CH00568, RHE_PF00273, RHE_CH02998, RHE_CH01873 | HisCch1+HisCch3+HisCch2, AatAc+AspB1+Ypf00130+AatAch+AspB2 | EC-2.6.1.5
DDPA | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase | [c] : e4p + h2o + pep --> 2dda7p + pi | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH02375, RHE_CH02369 | AroF+AroG | EC-4.1.2.15
SHK3Dr | shikimate dehydrogenase | [c] : 3dhsk + h + nadph <==> nadp + skm | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH00003, RHE_CH02291, RHE_PC00214 | AroEch1+AroEch2+AroEc | EC-1.1.1.25
PSCVT | 3-phosphoshikimate 1-carboxyvinyltransferase | [c] : pep + skm5p <==> 3psme + pi | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH00884 | AroA | EC-2.5.1.19
DHQS | 3-dehydroquinate synthase | [c] : 2dda7p --> 3dhq + pi | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH03825 | AroB | EC-4.2.3.4
CHORS | chorismate synthase | [c] : 3psme --> chor + pi | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH00935 | AroC | EC-4.2.3.5
SHKK | shikimate kinase | [c] : atp + skm --> adp + h + skm5p | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH03826 | AroK | [NAME]
CHORM | chorismate mutase | [c] : chor --> pphn | Phenylalanine Tyrosine Tryptophan Biosynthesis | RHE_CH03958 | TyrA | EC-5.4.99.5
PRO1x | proline oxidase (L-proline, NAD) | [c] : nad + pro-L --> 1pyr5c + (2) h + nadh | Proline Biosynthesis |  |  | EC-1.5.1.2
PROTRS | Prolyl-tRNA synthetase | [c] : atp + pro-L + trnapro --> amp + ppi + protrna | Proline Biosynthesis | RHE_CH01623 | ProS | EC-6.1.1.15
G5SADr | L-glutamate 5-semialdehyde dehydratase, reversible | [c] : glu5sa <==> 1pyr5c + h + h2o | Proline Biosynthesis
1ACPCE_Rhizobium | 1-aminocyclopropane-1-carboxylate endolyase (deaminating) | [c] : 1acpr1cx + h2o --> 2obut + h + nh3 | Propanoate Metabolism |  |  | EC-3.5.99.7
PPMi | phosphopentomutase | [c] : r5p --> r1p | Purine Metabolism | RHE_CH00198, RHE_CH03597 | DeoB, Pgm | EC-5.4.2.7
DADA | Deoxyadenosine deaminase | [c] : dad-2 + h + h2o --> din + nh4 | Purine Metabolism | RHE_CH00197 | Add
NTD11 | 5'-nucleotidase (IMP) | [c] : h2o + imp --> ins + pi | Purine Metabolism | RHE_CH03555 | [NAME] | EC-3.1.3.5
ADD | adenine deaminase | [c] : ade + h + h2o --> hxan + nh4 | Purine Metabolism | RHE_CH03094, RHE_CH03420 | AdeC1+AdeC2 | EC-3.5.4.2
ADA | Adenosine deaminase | [c] : adn + h + h2o --> ins + nh4 | Purine Metabolism | RHE_CH00197 | Add | EC-3.5.4.4
PYOPT | dATP:pyruvate O2-phosphotransferase | [c] : dadp + h + pep <==> datp + pyr | Purine Metabolism | RHE_CH03542 | PykA | EC-2.7.1.40
GARFTi | phosphoribosylglycinamide formyltransferase, irreversible | [c] : 10fthf + gar --> fgam + h + thf | Purine Metabolism | RHE_CH01487 | PurN | EC-2.1.2.2
ADNUC | adenosine hydrolase | [c] : adn + h2o --> ade + rib-D | Purine Metabolism | RHE_CH02485 | IunH2 | EC-3.2.2.8
[NAME] | 5'-nucleotidase (dGMP) | [c] : dgmp + h2o --> dgsn + pi | Purine Metabolism | RHE_CH03555 | [NAME] | EC-3.1.3.5
[NAME] | [NAME] 3'-diphosphate 5'-triphosphate | [c] : gdptp + h2o <==> h + pi + ppgpp | Purine Metabolism | RHE_CH00788, RHE_CH01492 | Ppx1+Ppx2 | EC-3.6.1.11
GLUPRT | glutamine phosphoribosyldiphosphate amidotransferase | [c] : gln-L + h2o + prpp --> glu-L + ppi + pram | Purine Metabolism | RHE_CH01428 | PurF | EC-2.4.2.14
HXPRTr | [NAME] (Hypoxanthine) | [c] : hxan + prpp <==> imp + ppi | Purine Metabolism | RHE_CH03800 | Hpt | EC-2.4.2.8
AIRCr | phosphoribosylaminoimidazole carboxylase | [c] : air + co2 <==> 5aizc + h | Purine Metabolism | RHE_CH03531, RHE_CH03532 | PurE+PurK | EC-4.1.1.21
PUNP5 | purine-nucleoside phosphorylase (Inosine) | [c] : ins + pi <==> hxan + r1p | Purine Metabolism | RHE_CH00192 | DeoD | EC-2.4.2.1
PUNP1 | purine-nucleoside phosphorylase (Adenosine) | [c] : adn + pi <==> ade + r1p | Purine Metabolism | RHE_CH00192 | DeoD | EC-2.4.2.1
GMPS2 | GMP synthase | [c] : atp + gln-L + h2o + xmp --> amp + glu-L + gmp + (2) h + ppi | Purine Metabolism | RHE_CH00297 | GuaA1 | EC-6.3.5.2
[NAME] | 5'-nucleotidase (AMP) | [c] : amp + h2o --> adn + pi | Purine Metabolism | RHE_CH03555 | [NAME] | EC-3.1.3.5
PUNP2 | purine-nucleoside phosphorylase (Deoxyadenosine) | [c] : dad-2 + pi <==> 2dr1p + ade | Purine Metabolism | RHE_CH00192 | DeoD | EC-2.4.2.1
[NAME] | nucleoside-diphosphate kinase (ATP:GDP) | [c] : atp + gdp <==> adp + gtp | Purine Metabolism | RHE_CH01472 | Ndk | EC-2.7.4.6
GUAD | guanine deaminase | [c] : gua + h + h2o --> nh4 + xan | Purine Metabolism | RHE_CH03130 | GuaD | EC-3.5.4.3
GTPDPK | GTP diphosphokinase | [c] : atp + gtp --> amp + gdptp + h | Purine Metabolism | RHE_CH01385 | RelA | EC-2.7.6.5
PRPPSi | phosphoribosylpyrophosphate synthetase | [c] : atp + r5p --> amp + h + prpp | Purine Metabolism | RHE_CH03023 | PrsAch | EC-2.7.6.1
PUNP7 | purine-nucleoside phosphorylase (Xanthosine) | [c] : pi + xtsn <==> r1p + xan | Purine Metabolism | RHE_CH00192 | DeoD | EC-2.4.2.1
NTPTP1 | Nucleoside triphosphate tripolyhydrolase | [c] : dgtp + h2o --> dgsn + pppi | Purine Metabolism | RHE_CH01817 | Dgt | EC-3.1.5.1
ADKd | adenylate [NAME] (d form) | [c] : damp + datp <==> (2) dadp | Purine Metabolism | RHE_CH01696 | Adk | EC-2.7.4.3
IMPD | IMP dehydrogenase | [c] : h2o + imp + nad --> h + nadh + xmp | Purine Metabolism | RHE_CH00794 | GuaB | EC-1.1.1.205
PRFGS | phosphoribosylformylglycinamidine synthase | [c] : atp + fgam + gln-L + h2o --> adp + fpram + glu-L + h + pi | Purine Metabolism | RHE_CH02281, RHE_CH02286 | PurQ+PurL | EC-6.3.5.3
IMPC | IMP cyclohydrolase | [c] : h2o + imp <==> fprica | Purine Metabolism | RHE_CH04107 | PurH | EC-3.5.4.10
PPGPPDP | guanosine-3',5'-bis(diphosphate) 3'-diphosphatase | [c] : h2o + ppgpp --> gdp + ppi | Purine Metabolism | RHE_CH01385 | RelA | EC-3.1.7.2
PRAGS | phosphoribosylglycinamide synthetase | [c] : atp + gly + pram --> adp + gar + h + pi | Purine Metabolism | RHE_CH00886 | PurD | EC-6.3.4.13
ADK1 | adenylate kinase | [c] : amp + atp <==> (2) adp | Purine Metabolism | RHE_CH01696 | Adk | EC-2.7.4.3
PRASCS | phosphoribosylaminoimidazolesuccinocarboxamide synthase | [c] : 5aizc + asp-L + atp <==> 25aics + adp + h + pi | Purine Metabolism | RHE_CH03409, RHE_CH02278 | PurC2+PurC1 | EC-6.3.2.6
GUAPRTr | guanine phosphoribosyltransferase | [c] : gua + prpp <==> gmp + ppi | Purine Metabolism | RHE_CH03800, RHE_CH03035, RHE_PD00341 | Hpt, [NAME], [NAME] | EC-2.4.2.8
PUNP3 | purine-nucleoside phosphorylase ([NAME]) | [c] : gsn + pi <==> gua + r1p | Purine Metabolism | RHE_CH00192 | DeoD | EC-2.4.2.1
NDPK5 | nucleoside-diphosphate kinase (ATP:dGDP) | [c] : atp + dgdp <==> adp + dgtp | Purine Metabolism | RHE_CH01472 | Ndk | EC-2.7.4.6
NTD9 | 5'-nucleotidase (GMP) | [c] : gmp + h2o --> gsn + pi | Purine Metabolism | RHE_CH03555 | [NAME] | EC-3.1.3.5
PRAIS | phosphoribosylaminoimidazole synthase | [c] : atp + fpram --> adp + air + (2) h + pi | Purine Metabolism | RHE_CH01488 | PurM | EC-6.3.3.1
PUNP4 | purine-nucleoside phosphorylase (Deoxyguanosine) | [c] : dgsn + pi <==> 2dr1p + gua | Purine Metabolism | RHE_CH00192 | DeoD | EC-2.4.2.1
NTD10 | 5'-nucleotidase (XMP) | [c] : h2o + xmp --> pi + xtsn | Purine Metabolism | RHE_CH03555 | [NAME] | EC-3.1.3.5
[NAME] | 5'-nucleotidase (dAMP) | [c] : damp + h2o <==> dad-2 + pi | Purine Metabolism | RHE_CH03555 | [NAME] | EC-3.1.3.5
DGK1 | deoxyguanylate [NAME] (dGMP:ATP) | [c] : atp + dgmp <==> adp + dgdp | Purine Metabolism | RHE_CH01448 | Gmk2 | EC-2.7.4.8
ADSL2r | adenylosuccinate lyase | [c] : 25aics <==> aicar + fum | Purine Metabolism | RHE_CH02273 | PurB | [NAME]
XPPT | xanthine phosphoribosyltransferase | [c] : [NAME] --> ppi + xmp | Purine Metabolism | RHE_CH03800 | Hpt | EC-2.4.2.22
PUNP6 | purine-nucleoside phosphorylase (Deoxyinosine) | [c] : din + pi <==> 2dr1p + hxan | Purine Metabolism | RHE_CH00192 | DeoD | EC-2.4.2.1
GK1 | [NAME] (GMP:ATP) | [c] : atp + gmp <==> adp + gdp | Purine Metabolism | RHE_CH01448 | Gmk2 | EC-2.7.4.8
AICARTi | phosphoribosylaminoimidazolecarboxamide formyltransferase | [c] : 10fthf + aicar --> fprica + thf | Purine Metabolism | RHE_CH04107 | PurH | EC-2.1.2.3
PYPRTr | pyrophosphate phosphoribosyltransferase | [c] : [NAME] <==> ppi + xmp | Purine Metabolism | RHE_CH03800 | Hpt | EC-2.4.2.8
ADPTr | adenine phosphoribosyltransferase (r) | [c] : ade + prpp <==> amp + ppi | Purine Metabolism | RHE_CH03035, RHE_PD00341, RHE_CH03800 | Aptch, [NAME], Hpt | EC-2.4.2.7
ADPRDP | ADPribose diphosphatase | [c] : adprib + h2o --> amp + (2) h + r5p | Purine Metabolism | RHE_CH01485 | Ypch00514 | EC-3.6.1.13
DCTPD2 | dCTP deaminase | [c] : ctp + h + h2o --> nh4 + utp | Pyrimidine Biosynthesis | RHE_CH00524 | Dcd | EC-3.5.4.13
NTD2 | 5'-nucleotidase (UMP) | [c] : h2o + ump --> pi + uri | Pyrimidine Biosynthesis | RHE_CH03555 | [NAME] | EC-3.1.3.5
DCYTD | deoxycytidine deaminase | [c] : dcyt + h + h2o --> duri + nh4 | Pyrimidine Biosynthesis | RHE_CH00191 | Cdd | EC-3.5.4.14
NTD4 | 5'-nucleotidase (CMP) | [c] : cmp + h2o --> cytd + pi | Pyrimidine Biosynthesis | RHE_CH03555 | [NAME] | EC-3.1.3.5
DUTPDP | dUTP diphosphatase | [c] : dutp + h2o --> dump + h + ppi | Pyrimidine Biosynthesis | RHE_CH00330 | Dut | EC-3.6.1.23
DURIPP | deoxyuridine phosphorylase | [c] : duri + pi <==> 2dr1p + ura | Pyrimidine Biosynthesis | RHE_CH00194, RHE_CH00192 | DeoA, DeoD
TMDS | thymidylate synthase | [c] : dump + mlthf --> dhf + dtmp | Pyrimidine Biosynthesis | RHE_CH02799 | ThyA | EC-2.1.1.45
UPPN | b-ureidopropionase | [c] : cala + (2) h + h2o --> ala-B + co2 + nh4 | Pyrimidine Biosynthesis | RHE_CH03290 | AmaB | EC-3.5.1.6
CSND | Cytosine deaminase | [c] : csn + h + h2o --> nh4 + ura | Pyrimidine Biosynthesis | RHE_CH02043, RHE_PB00107 | CodAch2, CodAB | EC-3.5.4.1
NDPK7 | nucleoside-diphosphate kinase (ATP:dCDP) | [c] : atp + dcdp <==> adp + dctp | Pyrimidine Biosynthesis | RHE_CH01472 | Ndk | EC-2.7.4.6
DHORD | dihydoorotic acid dehydrogenase | [c] : dhor-S + o2 <==> h2o2 + orot | Pyrimidine Biosynthesis | RHE_CH03278, RHE_CH00540 | Ypch01135+PyrD | EC-1.3.3.1
NTD3 | 5'-nucleotidase (dCMP) | [c] : [NAME] --> dcyt + pi | Pyrimidine Biosynthesis | RHE_CH03555 | [NAME] | EC-3.1.3.5
TMDK1 | [NAME] (ATP:thymidine) | [c] : atp + thymd --> adp + dtmp + h | Pyrimidine Biosynthesis | RHE_CH03084 | Tdk | EC-2.7.1.21
[NAME] | dihydroorotase | [c] : dhor-S + h2o <==> cbasp + h | Pyrimidine Biosynthesis | RHE_CH00351, RHE_CH03292, RHE_CH00469, RHE_CH01641 | Ypch00138+Dht+PyrC+Ypch00562 | EC-3.5.2.3
DTMPK | dTMP kinase | [c] : atp + dtmp <==> adp + dtdp | Pyrimidine Biosynthesis | RHE_CH02160 | [NAME] | EC-2.7.4.9
TRDRr | [NAME] reductase (NADPH) reversible | [c] : h + nadph + trdox <==> nadp + trdrd | Pyrimidine Biosynthesis | RHE_CH02975, RHE_PF00137 | TrxBch+TrxBf | EC-1.8.1.9
NDPK6 | nucleoside-diphosphate kinase (ATP:dUDP) | [c] : atp + dudp <==> adp + dutp | Pyrimidine Biosynthesis | RHE_CH01472 | Ndk | EC-2.7.4.6
RNDR3 | ribonucleoside-diphosphate reductase (CDP) | [c] : cdp + trdrd --> dcdp + h2o + trdox | Pyrimidine Biosynthesis |  |  | [NAME]
DURAD2 | dihydrothymin dehydrogenase (NADP) | [c] : 56dthm + nadp <==> h + nadph + thym | Pyrimidine Biosynthesis |  |  | EC-1.3.1.2
CYTDH | Cytidine hydrolase | [c] : cytd + h2o --> csn + rib-D | Pyrimidine Biosynthesis |  |  | EC-3.2.2.8
UPPRTr | uracil phosphoribosyltransferase (r) | [c] : [NAME] <==> ppi + ump | Pyrimidine Biosynthesis | RHE_CH00196 | Upp | EC-2.4.2.9
ORPT | orotate phosphoribosyltransferase | [c] : orot5p + ppi <==> orot + prpp | Pyrimidine Biosynthesis | RHE_CH00474 | PyrE | EC-2.4.2.10
NTD5 | 5'-nucleotidase (dTMP) | [c] : dtmp + h2o --> pi + thymd | Pyrimidine Biosynthesis | RHE_CH03555 | [NAME] | EC-3.1.3.5
NDPK4 | nucleoside-diphosphate kinase (ATP:dTDP) | [c] : atp + dtdp <==> adp + dttp | Pyrimidine Biosynthesis | RHE_CH01472 | Ndk | EC-2.7.4.6
UMPK | UMP kinase | [c] : atp + ump <==> adp + udp | Pyrimidine Biosynthesis | RHE_CH00098 | Cmk | EC-2.7.4.14
[NAME] | nucleoside-diphosphate kinase (ATP:UDP) | [c] : atp + udp <==> adp + utp | Pyrimidine Biosynthesis | RHE_CH01472 | Ndk | EC-2.7.4.6
DHPM2 | dihydropyrimidinase (dihydrothymine) | [c] : 56dthm + h2o --> 3uib + h | Pyrimidine Biosynthesis | RHE_CH03292 | [NAME] | EC-3.5.2.2
DURIK2 | deoxyuridine kinase (GTP:[NAME]) | [c] : duri + gtp --> dump + gdp + h | Pyrimidine Biosynthesis | RHE_CH03084 | Tdk
NDPK3 | nucleoside-diphosphate kinase (ATP:CDP) | [c] : atp + cdp <==> adp + ctp | Pyrimidine Biosynthesis | RHE_CH01472 | Ndk | EC-2.7.4.6
NDP8 | nucleoside-diphosphatase (dUDP) | [c] : [NAME] --> dump + h + pi | Pyrimidine Biosynthesis | RHE_CH02160 | [NAME] | EC-3.6.1.6
CYTD | cytidine deaminase | [c] : cytd + h + h2o --> nh4 + uri | Pyrimidine Biosynthesis | RHE_CH00191 | Cdd | EC-3.5.4.5
CTPS2 | CTP synthase (glutamine) | [c] : atp + gln-L + h2o + utp --> adp + ctp + glu-L + (2) h + pi | Pyrimidine Biosynthesis | RHE_CH02184 | PyrG | EC-6.3.4.2
CYTK1 | cytidylate kinase (CMP) | [c] : atp + cmp <==> adp + cdp | [NAME] | RHE_CH00098 | Cmk | EC-2.7.4.14
CYTK11 | cytidylate kinase (dCMP,dGTP) | [c] : [NAME] <==> dcdp + dgdp | [NAME] | RHE_CH00098 | Cmk | EC-2.7.4.14
MCSNAH | 5-Methylcytosine aminohydrolase | [c] : 5mcsn + h + h2o --> nh4 + thym | [NAME] | RHE_PB00107, RHE_CH02043 | CodAB+CodAch2 | EC-3.5.2.3
DHPM1 | dihydropyrimidinase (5,6-dihydrouracil) | [c] : 56dura + h2o --> cala + h | [NAME] | RHE_CH03292 | [NAME] | EC-3.5.2.2
DCTPD | dCTP deaminase | [c] : dctp + h + h2o --> dutp + nh4 | [NAME] | RHE_CH00524 | Dcd | EC-3.5.4.13
DURADx | dihydrouracil dehydrogenase (NAD) | [c] : 56dura + nad <==> h + nadh + ura | [NAME] |  |  | EC-1.3.1.1
BUP | beta-ureidopropionase | [c] : 3uib + (2) h + h2o --> 3aib + co2 + nh4 | [NAME] | RHE_CH03290 | AmaB | EC-3.5.1.6
OMPDC | orotidine-5'-phosphate decarboxylase | [c] : h + orot5p --> co2 + ump | [NAME] | RHE_CH00314 | PyrF | EC-4.1.1.23
ALAD_R | L-alanine dehydrogenase | [c] : ala-L + h2o + nad <==> h + nadh + nh4 + pyr | Reductive carboxylate cycle | RHE_CH01770 | AldA | [NAME]
DB4PS | 3,4-Dihydroxy-2-butanone-4-phosphate synthase | [c] : ru5p-D --> db4p + for + h | [NAME]
FMNAT | FMN adenylyltransferase | [c] : atp + fmn + h --> fad + ppi | [NAME] | RHE_CH00831 | RibF | EC-2.7.7.2
APRAUR | 5-amino-6-(5-phosphoribosylamino)uracil reductase | [c] : 5apru + h + nadph --> 5aprbu + nadp | [NAME] | RHE_CH01510, RHE_PD00036 | RibD, Ypd00011 | EC-1.1.1.193
RBFK | [NAME] | [c] : atp + ribflv --> adp + fmn + h | [NAME] | RHE_CH00831 | RibF | EC-2.7.1.26
RBFSa | riboflavin synthase | [c] : [NAME] --> dmlz + (2) h2o + pi | [NAME] |  |  | EC-2.5.1.9
ACP1(FMN) | acid phosphatase (FMN) | [c] : fmn + h2o --> pi + ribflv | [NAME] | RHE_CH01827 | SurE | EC-3.1.3.2
RBFSb | riboflavin synthase | [c] : (2) dmlz --> 4r5au + ribflv | [NAME] | RHE_CH02688, RHE_CH01511, RHE_CH01525 | RibH2+RibE+RibH1 | EC-2.5.1.9
PMDPHT | pyrimidine phosphatase | [c] : 5aprbu + h2o --> 4r5au + pi | [NAME]
DHPPDA | diaminohydroxyphosphoribosylaminopyrimidine deaminase | [c] : 25dhpp + h + h2o --> 5apru + nh4 | [NAME] | RHE_CH01510 | RibD | EC-3.5.4.26
SERATi | serine O-acetyltransferase, irreversible | [c] : accoa + ser-L --> acser + coa | Sulfur Metabolism | RHE_CH03627, RHE_CH01903 | CysE2+CysE1 | EC-2.3.1.30
SADT | sulfate adenylyltransferase | [c] : atp + h + so4 --> aps + ppi | Sulfur Metabolism | RHE_CH01130, RHE_CH01131 | CysN+CysD_r | [NAME]
SULRi | sulfite reductase (NADPH2) | [c] : (5) h + (3) nadph + so3 --> (3) h2o + h2s + (3) nadp | Sulfur Metabolism | RHE_CH01960 | CysI | EC-1.8.2.2
APS | APS-reductase | [c] : aps + (2) gthrd <==> amp + gthox + (2) h + so3 | Sulfur Metabolism
CYSS | cysteine synthase | [c] : acser + h2s --> ac + cys-L + h | Sulfur Metabolism | RHE_CH01775, RHE_CH00325 | CysK2+CysK1
PDH | pyruvate dehydrogenase | [c] : coa + nad + pyr --> accoa + co2 + nadh | [NAME]
GLUt2r | L-glutamate transport via proton symport, reversible | [NAME]] + h[e] <==> [NAME]] + h[c] | Tansport, [NAME]
PIt | Inorganic phosphate exchange, diffusion | pi[c] <==> pi[e] | Transport
[NAME] | Nitrogen exchange, diffusion | n2[e] <==> n2[c] | Transport
CO2t | CO2 transporter via diffusion | co2[e] <==> co2[c] | Transport
O2t | o2 transport (diffusion) | o2[e] <==> o2[c] | Transport
ORNTAC | ornithine transacetylase | [c] : acorn + glu-L <==> acglu + orn | Urea cycle/amino group metabolism | RHE_CH03768 | ArgJ | EC-2.3.1.35
ORNTAr | ornithine transaminase reversible | [c] : akg + orn <==> [NAME] | Urea cycle/amino group metabolism | RHE_CH03852 | RocD | EC-2.6.1.13
ACGS | N-acetylglutamate synthase | [c] : accoa [NAME] --> acglu + coa + h | Urea cycle/amino group metabolism | RHE_CH03768 | ArgJ | EC-2.3.1.1
AGPR | N-acetyl-g-glutamyl-phosphate reductase | [c] : acg5sa + nadp + pi <==> acg5p + h + nadph | Urea cycle/amino group metabolism | RHE_CH01567 | ArgC | EC-1.2.1.38
ACODA | acetylornithine deacetylase | [c] : acorn + h2o --> ac + orn | Urea cycle/amino group metabolism | RHE_PF00335 | ArgE | EC-3.5.1.16
GLU5K | glutamate 5-kinase | [c] : atp + glu-L --> adp + glu5p | Urea cycle/amino group metabolism | RHE_CH04068 | ProB | EC-2.7.2.11
UREA | urease | [c] : (2) h + h2o + urea --> co2 + (2) nh4 | Urea cycle/amino group metabolism | RHE_CH03310, RHE_CH03305, RHE_CH03308 | UreA+UreC+UreB | EC-3.5.1.5
G5SD | glutamate-5-semialdehyde dehydrogenase | [c] : glu5p + h + nadph --> glu5sa + nadp + pi | Urea cycle/amino group metabolism | RHE_CH04069 | ProA | EC-1.2.1.41
ARGN | arginase | [c] : arg-L + h2o --> orn + urea | Urea cycle/amino group metabolism | RHE_CH03851 | Argl | EC-3.5.3.1
ACGK | acetylglutamate kinase | [c] : acglu + atp --> acg5p + adp | Urea cycle/amino group metabolism | RHE_CH00428 | ArgB | EC-2.7.2.8
ACOTA | acetylornithine transaminase | [c] : acorn + akg <==> acg5sa + glu-L | Urea cycle/amino group metabolism | RHE_CH00516 | ArgD1 | EC-2.6.1.11
OCBTi | ornithine carbamoyltransferase, irreversible | [c] : cbp + orn --> citr-L + h + pi | Urea cycle/amino group metabolism |  |  | EC-2.1.3.3
DHAD2 | Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) | [c] : 23dhmp --> 3mop + h2o | [NAME], [NAME], and Isoleucine Metabolism | RHE_PC00044, RHE_CH01704, RHE_CH03160, RHE_CH03347 | IlvDc+IlvDch1+IlvDch2+Ypch01167
KARA2 | ketol-acid reductoisomerase (2-Acetolactate) | [c] : 2ahbut + h + nadph <==> 23dhmp + nadp | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH02744 | IlvC | EC-1.1.1.86
VALTRS | Valyl-tRNA synthetase | [c] : atp + trnaval + val-L --> amp + ppi + valtrna | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH01811 | ValS | [NAME]
ilvg | Isoleucine biosynthesi step i | [c] : 2obut + hethmpp --> 2ahbut + thmpp | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH02878, RHE_PF00274, RHE_CH02790, RHE_CH02789 | IlvG+IlvB+IlvI+IlvH
OMCDC | 2-Oxo-4-methyl-3-carboxypentanoate decarboxylation | [c] : 3c4mop + h --> 4mop + co2 | [NAME], [NAME], and Isoleucine Metabolism
KARA1 | ketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate) | [c] : 23dhmb + nadp <==> alac-S + h + nadph | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH02744 | IlvC | EC-1.1.1.86
IPMDr | 3-isopropylmalate dehydrogenase reversible | [c] : 3c2hmp + nad <==> 3c4mop + h + nadh | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH04093 | LeuB | EC-1.1.1.85
IPPS | 2-isopropylmalate synthase | [c] : 3mob + accoa + h2o --> 3c3hmp + coa + h | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH03067, RHE_CH01419 | LeuA2+LeuA1 | EC-4.1.3.12
ILETAi | isoleucine transaminase | [c] : 3mop + glu-L --> akg + ile-L | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH01190, RHE_CH02730 | IlvE1+IlvE2 | EC-2.6.1.42
IPPMIb | 2-isopropylmalate hydratase | [c] : 2ippm + h2o <==> 3c3hmp | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH04091, RHE_CH03965 | LeuD+LeuC | EC-4.2.1.33
ACLS_b | acetolactate synthase | [c] : hethmpp + pyr --> alac-S + thmpp | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH02878, RHE_PF00274, RHE_CH02790, RHE_CH02789 | IlvG+IlvB+IlvI+IlvH | EC-4.1.3.18
ACLS_a | acetolactate synthase | [c] : h + pyr + thmpp --> co2 + hethmpp | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH02878, RHE_PF00274, RHE_CH02790, RHE_CH02789 | IlvG+IlvB+IlvI+IlvH | EC-4.1.3.18
LEUTRS | Leucyl-tRNA synthetase | [c] : atp + leu-L + trnaleu --> amp + leutrna + ppi | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH04116 | LeuS | EC-6.1.1.4
LEUTAi | leucine transaminase (irreversible) | [c] : 4mop + glu-L --> akg + leu-L | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH01190, RHE_CH02730 | IlvE1+IlvE2 | EC-2.6.1.42
VALTAi | valine transaminase | [c] : 3mob + glu-L --> akg + val-L | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH01190, RHE_CH02730 | IlvE1+IlvE2 | EC-2.6.1.42
ILETRS | Isoleucyl-tRNA synthetase | [c] : atp + ile-L + trnaile --> amp + iletrna + ppi | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH00832 | IleS | EC-6.1.1.5
IPPMIa | 3-isopropylmalate dehydratase | [c] : 3c2hmp <==> 2ippm + h2o | [NAME], [NAME], and Isoleucine Metabolism | RHE_CH04091, RHE_CH03965 | LeuD+LeuC | EC-4.2.1.33
DHAD1 | dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) | [c] : 23dhmb --> 3mob + h2o | [NAME], [NAME], and Isoleucine Metabolism | RHE_PC00044, RHE_CH01704, RHE_CH03160, RHE_CH03347 | IlvDc+IlvDch1+IlvDch2+Ypch01167 | EC-4.2.1.9
Exchange Reactions
 | Exchange reaction for alanine | [e] : ala-L <==>
 | Exchange reaction for aspartate | [e] : asp-L <==>
 | Exchange reaction for CO2 | [e] : co2 <==>
 | Exchange reaction for glutamate | [e] : glu-L <==>
 | Exchange reaction for proton | [e] : h <==>
 | Exchange reaction for water | [e] : h2o <==>
 | Exchange reaction for n2 | [e] : n2 <==>
 | Exchange reaction for oxygen | [e] : o2 <==>
 | Exchange reaction for phosphate | [e] : pi <==>
 | Exchange reaction for succinate | [e] : succ <==>
 | Exchange reaction for arginine | [e] : arg-L <==> | Used only in Arginine Deiminase Mutant Simulations
 | Exchange reaction for ornithine | [e] : orn <==> | Used only in Arginine Deiminase Mutant Simulations
Sinks
 | Cytosolic source for myo-inositol | [c] : inost <==>
Objectives Function
OF14e_Retli  (Original Objective function) | Wildtype Objective Function | [e] : ala-L + asp-L + glycogen + lys-L + nh4 + phb --> | Objective function in wild type
OF14ae_Retli (OF with phb deletion) | Objective Function w/out PHB | [e] : ala-L + asp-L + glycogen + lys-L + nh4 --> | Objective function in PHB mutant
OF14be_Retli (OF with glycogen deletion) | Objective Function w/out Glycogen | [e] : ala-L + asp-L + lys-L + nh4 + phb --> | Objective function in Glycogen mutant
OF14ce_Retli (OF with phb and glycogen deletion) | Objective Function w/out PHB and Glycogen | [e] : ala-L + asp-L + lys-L + nh4 --> | Objective function in PHB and Glycogen mutant