Spreadsheet: 91c8d3ec-2885-4040-a6de-342fc8404e99
Sheet: Sheet1

[NAME]. | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9
Supplementary Table 4: Homologs of focus mutants in eukaryotic species
% similarility as computed by BLAST search
Gene | H. sapiens | M. musculus | R. norvegicus | D. rerio | D. melanogaster | C. elegans | S. pombe | S. cerevisiae | C. albicans
[NAME] |  |  |  |  |  |  |  |  | Ahc1p (26%)
ATR1 | LOC124976 (22%) | BC011467 (22%) |  |  | CG9254 (27%); CG4330 (24%) | M01F1.5 (23%); Y51A2D.5 (27%) | Spbc1683.03cp (39%); Spcc1529.01p (22%) | Ymr279p (62%); Yor378p (40%); [NAME] (24%) | Atr1p (43%); Orf19.2350p (35%); Sge1p (24%)
BCK1 | MAP3K3 (40%); MAP3K2 (41%); MAP3K1 (28%) | MAP3K3 (38%); MAP3K2 (40%); MAP3K1 (27%) | MAP3K1 (28%); PAK3 (26%); PAK1 (29%) | NEK8 (35%); CDK5 (31%); [NAME] (31%) | PK92B (37%); MEKK1 (36%); CG5169 (34%) | NSY-1 (37%); [NAME] (34%); [NAME] (34%) | Mkh1p (28%); [NAME] (46%); Cdc7p (37%) | Mkh1p (28%); [NAME] (46%); Cdc7p (37%) | Bck1p (32%); Ste11p (45%); Cdc15p (33%)
BDF1 | BRDT (26%); [NAME] (25%); BRD3 (25%) | BRD3 (24%); BRD4 (26%); [NAME] (25%) | [NAME] (25%); BRDT (27%); CREBBP (32%) | SMARCA4 (23%) | FS(1)H (31%); TOU (34%); CG11375 (24%) | Y119C1B.8 (26%); F57C7.1 (22%) | Spcc191.13p (30%); Spac631.02p (29%) | Bdf2p (43%); Gcn5p (45%); Spt7p (24%) | Bdf1p (41%); Gcn5p (33%); Spt7p (33%)
BDF2 | BRDT (28%); [NAME] (23%); BRD4 (23%) | BRDT (28%); BRD3 (24%); [NAME] (27% | BRDT (29%); [NAME] (26%); CREBBP (24%) | SMARCA4 (22%); [NAME] (32%) | FS(1)H (30%); CG11375 (24%); NEJ (34%) | Y119C1B.8 (23%); F57C7.1 (25%) | Spcc191.13p (29%); Spac631.02p (27%) | Bdf1p (43%); Gcn5p (30%); Spt7p (21%) | Bdf1p (37%); [NAME] (22%); Gcn5p (26%)
BUB2 | [NAME] (23%); TBC1D8 (26%); TBC1D13 (27%) | TBC1D13 (28%); A630047E20RIK (23%) | TBC1D10A (24%); RUTBC3 (21%) |  | CG5978 (28%); CG4041 (24%); CG5916 (20%) | C33F10.2 (25%); F41D9.1 (26%) | Cdc16p (37%); Spbc215.01p (25%) | Mdr1p (21%); Gyp5p (26%) | Bub2p (44%); Gyp2p (23%); Orf19.4315p (24%)
BUD27 | [NAME] (26%) | UXT (27%) | UXT (24%) |  |  |  |  |  | Bud27p (25%)
CBT1 |  |  |  |  |  |  |  | Ynl311p (24%
COX16 | [NAME] (29%) | 1810020G14RIK (30%) |  |  |  |  | Spac1486.08p (34%) |  | Orf19.7665p (48%)
CTF19
CTF4 | WDHD1 (20%) | WDHD1 (21%) |  |  |  |  | Mcl1p (25%) |  | Ctf4p (29%)
DAK2 | DAK (36%) | DAK (36%) | RGD1311026 (36%) |  |  | W02H5.A (33%) | Dak2p (76%); Dak1p (75%) | Dak1p (44%) | Dak2p (45%)
DDC1 |  |  |  |  |  |  |  |  | Ddc1p (22%)
DDR2
ECM11 | NOLC1 (23%) |  |  |  | NOPP140 (25%) | UNC-89 (27%); W09G12.7 (22%) | Spbc354.10p (22%); Spac1142.04p (23%) | Uso1p (23%) | Orf19.497p (23%); Orf19.7492p (22%)
ELG1 | C17ORF41 (29%) | C130052G03RIK (24%) |  |  | CG16838 (22%) |  | Elg1p (28%) |  | Elg1p (25%)
ESC2 | SUMO2 (27%); SUMO3 (29%); [NAME] (26%) | SUMO2 (27%); SUMO3 (29%); [NAME] (26%) | LOC499417 (29%); SUMO2 (27%); [NAME] (26%) |  |  | SMO-1 (24%); M04C9.6 (21%); F16A11.3 (21%) | Ubl2p (25%) |  | Esc2p (26%)
GDH1 | GLUD2 (25%); GLUD1 (25%) | GLUD1 (25%) | GLUD1 (25%) |  | CG4434 (27%); GDH (27%) | ZK829.4 (26%) | [NAME] (61%) | Gdh3p (87%) | Gdh3p (73%)
GSH2 | GSS (36%) | GSS (36%) | GSS (37%) |  | CG32495 (36%); CG6835 (29%) | M176.2 (30%) | [NAME] (37%) |  | [NAME] (49%)
HPR1
HRT2 | C6ORF211 (31%) | 1700052N19RIK (31%) | RGD1305235 (31%) |  | CG11474 (29%); CG2921 (26%); CG11475 (29%) | F31D4.2 (31%) | Spac806.04cp (38%); Spcc1393.13p (38%) |  | Hrt2p (44%)
HST3 | SIRT1 (29%); SIRT2 (34%); SIRT3 (29%) | SIRT2 (32%); SIRT1 (32%); SIRT3 (30%) | SIRT2 (33%); SIRT5 (22%); SIRT6 (23%) |  | SIR2 (30%); SIRT2 (28%); SIRT6 (24%) | SIR-2.1 (25%); SIR-2.3 (25%) | Hst4p (37%); Sir2p (28%); Spcc132.02p (27%) | Hst4p (34%); Sir2p (30%); Hst1p (30%) | Hst3p (44%); Hst2p (29%); Sir2p (29%)
IRC10 |  |  |  |  |  |  |  | Ykr015p (28%)
IRC11 |  |  |  |  |  |  |  | Ydr391p (57%)
IRC13
IRC14
IRC15 | DLD (34%); GSR (25%); TXNRD1 (23%) | DLD (33%); GSR (26%); TXNRD2 (23%) | DLD (32%); TXNRD1 (23%); TXNRD2 (23%) | TXNRD1 (23%); TXNRD3 (24%) | CG7430 (35%); TRXR-2 (23%); [NAME] (22%) | LLC1.3 (35%); C46F11.2 (26%); TR-SE (23%) | Dld1p (36%); Pgr1p (25%) | Lpd1p (41%); Glr1p (26%) | Lpd1p (38%); Glr1p (22%)
IRC16
IRC18 |  |  |  |  |  |  |  | Yjl038p (38%)
IRC19
IRC2
IRC20 | SHPRH (21%); TTF2 (26%); SMARCA3 (24%) | TTF2 (26%); SHPRH (20%); SMARCA3 (26%) | TRIM39 (33%); SMARCA4 (26%) | SMARCA4 (27%); [NAME] (31%) | CG7376 (22%); LDS (24%); CG10445 (21%) | F54E12.2 (29%); T23H2.3 (29%) | Spac144.05p (24%); [NAME] (25%) | Ris1p (25%); Rad16p (30%); Rad5p (22%) | Rad16p (29%); Ris1p (25%); Rad5p (25%)
IRC21 | CYB5R4 (40%); FADS3 (39%); CYB5B (34%) | CYB5R4 (41%); CYB5B (34%); FADS3 (37%) | CYB5R4 (40%); FADS3 (37%); CYB5B (34%) | FADS2 (42%) | CG11257 (37%); CG6870 (38%); CYT-B5 (37%) | Y52B11A.3 (44%); F58B4.2 (34%) | Spcc330.03cp (33%); Spac1f12.10p (34%) | Cyb2p (42%); Cyb5p (31%) | Orf19.4522p (32%); Cyb5p (40%); Cyb3p (35%)
IRC22 |  |  |  |  |  |  |  |  | Orf19.1372p (26%); Orf19.1782p (25%)
IRC23 |  |  |  |  |  |  |  | Bsc2p (35%)
IRC24 | SPR (29%); MGC4172 (28%); HSD11B1 (31%) | SPR (29%); BC022224 (27%); HSD11B1 (30%) | SPR (28%); HSD11B1 (31%); [NAME] (24%) | CBR1 (25%); RDH1 (28%); CBR1L (30%) | CG3699 (31%); CG31549 (31%); CG31548 (30%) | [NAME] (27%); R11D1.11 (30%) | Spbc30d10.05cp (38%); Spcc663.09cp (25%) | Yir035p (52%); [NAME] (30%); Ayr1p (27%) | Orf19.5194.1p (46%); Orf19.6833.2p
IRC25 |  |  |  |  |  |  |  |  | Orf19.5227p (28%)
IRC3 | DDX48 (23%); DDX52 (24%); [NAME] (25%) | DDX48 (23%); DDX52 (24%); [NAME] (25%) | DDX52 (24%); EIF4A2 (23%); EIF4A1 (20%) | DDX49 (21%) | PIT (21%); EIF-4A (22%); CG7483 (22%) | R05D11.4 (18%); F33D11.10 (21%) | Spbc3b8.12p (41%); Spac1093.05p (22%) | Dbp3p (21%); Drs1p (20%); Tif1p (20%) | Orf19.2798p (39%); Orf19.2797p (36%)
IRC4
IRC5 | HELLS (40%); SMARCA2 (35%); SMARCA1 (36%) | HELLS (39%); SMARCA2 (35%); SMARCA1 (35%) | SMARCA2 (35%); SMARCA4 (33%) | SMARCA4 (34%) | ISWI (34%); BRM (36%); KIS (34%); CHD1 (37%) | C52B9.8 (33%); PSA-4 (34%); T04D1.4 (31%) | Snf21p (33%); Snf22p (33%); Hrp1p (30%) | Snf2p (32%); Isw1p (37%); Chd1p (37%) | Orf19.1720p (40%); Isw2p (37%); Isw1p (37%)
IRC6 |  |  |  |  |  |  |  |  | Orf19.1420p (24%)
IRC7 | CTH (33%) | CTH (31%) | CTH (30%) |  | EIP55E (30%) | C12C8.2 (31%); [NAME] (35%) | Spcc11e10.01p (26%); [NAME] (25%) | Cys3p (28%); Met17p (26%); Str3p (27%) | Cys3p (26%); Str3p (27%); Met15p (27%)
IRC8 |  |  |  |  | CG6004 (22%) |  | Spcc320.02cp (26%); [NAME] (24%) |  | Orf19.4906p (22%)
IRC9
IZH2 | ADIPOR2 (39%); ADIPOR1 (38%); [NAME] (26%) | ADIPOR2 (39%); ADIPOR1 (38%); [NAME] (26%) | ADIPOR2 (39%); ADIPOR1 (38%); [NAME] (26%) | [NAME] (27%); MPRB (29%) | [NAME] (39%); CG7530 (24%); CG33203 (40%) | C43G2.1 (36%); Y32H12A.5 (34%) | Spbc12c2.09cp (40%); Spac30d11.11p (30%) | Ydr492p (44%); [NAME] (22%); Yol101p (28%) | Orf19.55p (39%); Orf19.5754p (31%)
LAG2
LCB5 | [NAME] (23%); SPHK1 (25%); CERK (31%) | SPHK1 (24%); [NAME] (23%); CERK (31%) | [NAME] (22%); SPHK1 (24%) |  | SK1 (25%); SK2 (25%); CG16708 (24%) | C34C6.5 (24%); T10B11.2 (26%) | Spac4a8.07cp (31%) | Lcb4p (52%) | Lcb4p (41%); Orf19.4680p (29%)
LRS4 |  |  |  |  |  |  |  |  | Pol0p (24%); Orf19.2372p (22%)
MAD1 |  |  |  |  |  |  | Mad1p (23%); Spac26a3.10p (28%) | Efr3p (22%) | Mad1p (26%)
MAD2 | MAD2L1 (43%); MAD2L2 (29%) | MAD2L1 (43%); MAD2L2 (29%) | MAD2L2 (34%) |  | CG17498 (36%); CG2948 (24%) | MDF-2 (40%) | [NAME] (48%); Spac12d12.09p (31%) |  | [NAME] (44%); Orf19.1406p (23%)
MAD3 | BUB1B (33%); BUB1 (21%) | BUB1B (34%); BUB1 (27%) |  |  | BUB1 (25%); CG14030 (25%) | SAN-1 (25%) | Mad3p (30%); [NAME] (30%) | Bub1p (35%) | Bub1p (29%)
MDM20 | C12ORF30 (21%) | C330023M02RIK (21%) | RGD1305685 (21%) |  | CG4845 (21%) |  | Arm1p (23%) |  | [NAME] (23%)
MED1
MLH1 | MLH1 (37%); PMS2 (32%); PMS1 (25%) | MLH1 (37%); PMS2 (26%); [NAME] (24%) | MLH1 (37%); [NAME] (25%) |  | MLH1 (28%); PMS2 (24%) | MLH-1 (32%); PMS-2 (25%) | Mlh1p (38%); Pms1p (30%) | Pms1p (26%); Mlh3p (22%); Mlh2p (25%) | Mlh1p (45%); Pms1p (27%); Mlh3p (24%)
MMS1
MRP17 | [NAME] (29%) | [NAME] (30%) |  |  | [NAME] (23%) |  | Mrp17p (37%) |  | Mrp17p (48%)
MRPL1 |  |  |  |  |  |  | Spac1610.02cp (29%) |  | [NAME] (38%)
MRPS16 | MRPS16 (40%) | MRPS16 (38%) |  |  | MRPS16 (36%) | F56D1.3 (35%) | [NAME] (51%) |  | Lpa4p (47%) [
MUS81 | MUS81 (24%) | MUS81 (23%) | MUS81 (24%) |  | MUS81 (31%) | C43E11.2 (24%) | Mus81p (28%) |  | Orf19.4206p (33%)
NUP133 |  |  |  |  |  |  | Nup132p (21%); [NAME] (21%) |  | Nup133p (24%)
NUP60 | DSPP (20%); [NAME] (25%) | NOLC1 (20%) | NEFH (23%); MUC4 (22%) |  | CG6004 (20%); DP (24%); CG32580 (22%) | [NAME] (21%); [NAME] (21%); ZC449.5 (24%) | Spcc285.13cp (23%); Spapb15e9.01cp (21%) | Muc1p (21%); Msb2p (22%); Ymr317p (22%) | Nup60p (25%); Pga55p (21%); Orf19.4906p (20%)
PAC10 | VBP1 (42%) | VBP1 (43%) |  |  | CG6719 (37%); CG15676 (24%) | VBP-1 (33%) | Spac3h8.07cp (43%) |  | Pac10p (49%)
PDR10 | ABCG2 (29%); [NAME] (26%); [NAME] (28%) | ABCG2 (28%); [NAME] (28%); ABCG5 (25%) | ABCG2 (27%); [NAME] (28%); ABCG8 (26%) |  | W (27%); ST (31%); CG9664 (27%); CG5853 (27%) | T26A5.1 (30%); C10C6.5 (30%) | Bfr1p (38%); Spapb24d3.09cp (28%) | Pdr5p (67%); Pdr15p (66%); Snq2p (40%) | Cdr1p (52%); Cdr2p (52%); Cdr4p (51%)
POM152 |  |  |  |  |  |  | Spbc29a10.07p (30%) |  | Pom152p (29%)
RAD51 | RAD51 (67%); DMC1 (48%); [NAME] (27%) | RAD51 (66%); DMC1H (48%); [NAME] (27%) |  |  | RAD51 (56%); SPN-D (31%); SPN-B (31%) | RAD-51 (52%) | Rhp51p (71%); Dmc1p (47%); Rhp57p (27%) | Dmc1p (46%); Rad57p (33%) | Rad51p (72%); Dlh1p (42%); Rad57p (23%)
RAD54 | RAD54L (44%); RAD54B (42%); [NAME] (33%) | RAD54L (45%); E130016E03RIK (40%) | SMARCA4 (33%); SMARCA2 (32%) | SMARCA4 (33%) | OKR (42%); KIS (30%); ISWI (32%); CHD3 (30%) | RAD-54 (47%); Y116A8C.13 (35%) | Rad54p (54%); [NAME] (35%); [NAME] (35%) | Rdh54p (36%); Isw2p (31%); [NAME] (34%) | Rad54p (58%); [NAME] (39%); [NAME] (34%)
RAD57 | XRCC3 (30%); [NAME] (28%); RAD51C (27%) | DMC1H (28%); [NAME] (31%); RAD51C (29%) |  |  | SPN-B (33%); RAD51 (34%); SPN-D (30%) | RAD-51 (30%) | Rhp57p (37%); Rhp51p (32%); Dmc1p (27%) | Dmc1p (33%); Rad51p (33%) | Rad57p (27%); Rad51p (36%); Dlh1p (33%)
RAD59 | RAD52 (38%) | RAD52 (39%) |  |  |  |  | Rti1p (31%); Rad22p (30%) | Rad52p (29%) | Rad59p (27%); [NAME] (31%)
RCO1 | PHF12 (22%); CHD5 (28%); [NAME] (45%) | PHF12 (23%); TRIM33 (29%); CHD3 (42%) | [NAME] (36%); [NAME] (35%); MYST3 (33%) |  | CG3815 (37%); MI-2 (47%); CHD3 (41%) | CHD-3 (44%); LET-418 (45%); C44B9.4 (22%) | Spac2f7.07cp (26%); Spac16c9.05p (25%) | Yjr119p (41%) | Orf19.6506p (27%); Orf19.5651p (36%)
RIM9 |  |  |  |  |  |  | Spcc1739.10p (22%) | Tos7p (27%) | Rim9p (30%)
RMI1 |  |  |  |  |  |  | Rmi1p (23%) |  | Nce4p (26%) [
RRM3 | [NAME] (36%) | AI449441 (35%) |  | WU_FE11D03 (37%) | CG3238 (33%) | PIF-1 (35%); C11G6.2 (34%) | Rph1p (41%) | Pif1p (38%); Dna2p (24%) | Pif1p (35%); Pif2p (37%)
RTT101 | CUL2 (22%); CUL1 (23%); CUL4B (20%) | CUL1 (23%); CUL2 (22%) |  |  | LIN19 (21%); GFT (25%) | CUL-4 (23%); CUL-1 (21%); [NAME] (21%) | Pcu4p (21%) | Cdc53p (21%) | Cul4p (21%)
RTT103 | C20ORF77 (25%); P15RS (30%); KIAA0460 (21%) | 2610304G08RIK (25%); [NAME] (24%) |  |  | CG15160 (24%); CG9018 (27%); CG9297 (31%) | C02F5.4 (19%) | Spbc337.03p (23%) |  | Rtt103p (27%); Pch1p (25%)
RTT107 |  |  |  |  | CG32133 (27%) |  | Brc1p (21%); Rad4p (26%) |  | [NAME] (24%)
RTT109 |  |  |  |  |  |  | Spbc342.06cp (27%) |  | [NAME] (32%)
SAE2
SGO1 |  |  |  |  |  |  |  |  | Orf19.3550p (26%)
SGS1 | BLM (34%); RECQL (39%); WRN (28%) | RECQL (36%); BLM (31%); [NAME] (38%) | RECQL (40%); DDX52 (21%); DDX5 (24%) | EIF4A1 (21%); PL10 (21%); [NAME] (21%) | MUS309 (30%); RECQ5 (36%); [NAME] (31%) | HIM-6 (32%); K02F3.12 (34%); WRN-1 (27%) | Hus2p (37%); Spac212.11p (24%) | Dhh1p (23%); Prp5p (21%); Dbp3p (24%) | Sgs1p (42%); [NAME] (24%); Dhh1p (24%)
SLX8 | [NAME] (32%); [NAME] (35%); RNF5 (36%) | [NAME] (32%); [NAME] (35%); RNF5 (36%) | [NAME] (31%); MGC109455 (36%); BRCA1 (33%) |  | CG32581 (28%); CG8974 (28%); CG12099 (36%) | Y38F1A.2 (31%); [NAME] (35%) | Slx8p (26%); Spcc548.05cp (30%) | Rad5p (28%) | Orf19.5438p (31%); Orf19.2223p (29%)
[NAME] | FAM44A (22%) | WBP11 (23%) | WBP11 (26%); [NAME] (19%) | STM (21%) | CG3996 (21%); PPN (21%); CG15040 (18%) |  | Spbc1711.05p (22%); Rhp16p (22%) | Net1p (22%); Ymr086p (20%); Srp40p (18%) | Orf19.267p (21%); Srp40p (20%); Nsr1p (26%)
TRF4 | POLS (37%); PAPD5 (33%); [NAME] (21%) | POLS (34%); 5730445M16RIK (38%) | PAPD4 (20%) |  | CG11265 (37%); CG17462 (32%); CG7163 (25%) | TRF-4 (35%); [NAME] (24%); F31C3.2 (26%) | [NAME] (31%); Cid12p (29%); Cid11p (27%) | Trf5p (57%) | Trf4p (48%); Papap (30%); Pap1p (24%)
VPS71 | ZNHIT1 (47%) | ZNHIT1 (47%) |  |  | CG14038 (29%) |  | [NAME] (30%) |  | Vsp71p (26%); Orf19.6597p (25%)
VPS72 | VPS72 (26%); C9ORF78 (24%) | VPS72 (26%); DSPP (18%); JMJD1C (23%) | DSPP (30%) |  |  | T06D8.1 (22%) | Spbc1711.05p (21%); Swc2p (24%) | Muc1p (24%); Srp40p (18%); Yif2p (23%) | Vps72p (28%); Hyr10p (22%); Rts1p (22%)
WSS1 |  |  |  |  |  |  | Spcc1442.07cp (28%); Spac521.02p (39%) |  | Wss1p (33%)
[NAME]