Spreadsheet: 946168f9-d149-457d-b0e5-f013c11e5e39
Sheet: Sheet1

Ka value calculated by MITOMI. | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Ka value normalized so strongest site for each variant = 1. | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12
DNA Seq | WQR | RQR | RTR | SAR | TRR |  | DNA Seq | WQR | RQR | RTR | SAR | TRR
AAA | 2.3543071219826e-05 | 4.606866536140361e-06 | 0.000119101824980864 | 0.000229020052510399 | 6.44633043524784e-05 |  | AAA | 0.1235395129160895 | 0.04244259891842853 | 0.322946260566661 | 0.8523342565546556 | 0.3602551670761317
GAA | 5.69330410658936e-05 | 2.255633900861515e-05 | 8.46689615388094e-05 | 0.00017363864150501 | 7.73699127606869e-05 |  | GAA | 0.2987494748004335 | 0.207809286876547 | 0.2295810708141055 | 0.6462235983009086 | 0.4323841467365824
AAC | 4.26917365750855e-05 | 1.123444296650386e-05 | 7.527397252613e-05 | 0.000208490858407715 | 6.77738185187072e-05 |  | AAC | 0.224019894973883 | 0.1035017952351542 | 0.20410642699402 | 0.7759316219321573 | 0.3787560777266545
GAC | 3.72919753830812e-05 | 1.15493736355019e-05 | 5.68404705221063e-05 | 0.000154004536296306 | 0.000178937903585587 |  | GAC | 0.1956852796089321 | 0.1064032198730371 | 0.1541237290605166 | 0.57315217821023 | 1
AAG | 4.88694484026633e-05 | 1.022132373371748e-05 | 7.5161872038919e-05 | 0.000181907373478523 | 6.04774125491781e-05 |  | AAG | 0.2564367153194049 | 0.09416802944958762 | 0.2038024649585238 | 0.6769969888492051 | 0.3379798876443827
GAG | 4.99384080952305e-05 | 1.28901929649313e-05 | 7.02576945452275e-05 | 0.000136007015519116 | 7.01027235628236e-05 |  | GAG | 0.2620459562936868 | 0.1187560537514689 | 0.1905047192439026 | 0.5061715652756632 | 0.3917712354850132
AAT | 4.08860172785584e-05 | 9.876466503914093e-06 | 7.90729238891881e-05 | 0.00012935721529025 | 5.52054850358153e-05 |  | AAT | 0.2145445941402226 | 0.09099089441130453 | 0.2144073366313941 | 0.4814232846243428 | 0.3085175579326613
GAT | 4.27210719930289e-05 | 1.214240555974574e-05 | 7.43621831884427e-05 | 0.000105721996312214 | 6.53277207469527e-05 |  | GAT | 0.2241738291488289 | 0.1118667634571742 | 0.2016340974803624 | 0.3934610884090743 | 0.3650859847908416
ACA | 0.000135161519241665 | 3.657354803439411e-05 | 9.18583081400191e-05 | 0.00017124919921756 | 6.607580556054289e-05 |  | ACA | 0.7092442653808261 | 0.3369484264565148 | 0.2490750844545459 | 0.6373309118600062 | 0.3692666798733252
GCA | 0.000190571183778399 | 7.019205986175216e-05 | 0.000159314918697723 | 0.000199053662617617 | 7.00759476599637e-05 |  | GCA | 1 | 0.6466724009909336 | 0.4319846253756207 | 0.740809608948824 | 0.3916215975250094
ACC | 6.08895177940528e-05 | 7.613670752646941e-05 | 0.000232336626385563 | 0.00015400624821098 | 6.78416797578325e-05 |  | ACC | 0.3195106237302732 | 0.7014398431483418 | 0.6299840048290308 | 0.573158549370768 | 0.3791353223571408
GCC | 5.59065811359378e-05 | 8.800139401652527e-05 | 0.000368797659312979 | 0.0001484218159174 | 6.82973190181516e-05 |  | GCC | 0.2933632463602019 | 0.8107480086964214 | 1 | 0.5523752035674034 | 0.3816816764341078
ACG | 6.89178610427873e-05 | 3.578215022858456e-05 | 0.000140999892025639 | 0.000243101353320943 | 5.39937097417577e-05 |  | ACG | 0.3616384160310759 | 0.3296573579192786 | 0.3823231749580598 | 0.9047400390445208 | 0.3017455142807807
GCG | 6.37105753226268e-05 | 6.262423573249353e-05 | 0.000252463980120127 | 0.000261379720606433 | 7.43446717687601e-05 |  | GCG | 0.3343137931950461 | 0.5769507970148762 | 0.6845596053685206 | 0.9727658665672163 | 0.4154774940302161
ACT | 7.20072411595151e-05 | 6.36142938127055e-05 | 0.000173106401555094 | 0.000176481391597094 | 6.83455062316953e-05 |  | ACT | 0.3778495768974545 | 0.5860721027168623 | 0.4693804236110615 | 0.6568033412524436 | 0.3819509721650743
GCT | 6.66985762216611e-05 | 8.241155321677955e-05 | 0.000333536266755842 | 0.000176221898842856 | 6.47775232779732e-05 |  | GCT | 0.3499929784726524 | 0.7592493665672657 | 0.9043882419893221 | 0.655837598028912 | 0.3620111892447077
AGA | 5.84962259330523e-05 | 1.068655421161685e-05 | 8.43648729201381e-05 | 0.000245420513412425 | 6.4715933883287e-05 |  | AGA | 0.3069521045798466 | 0.098454151138421 | 0.2287565302808555 | 0.9133711592051225 | 0.3616669950105513
GGA | 6.48147363463426e-05 | 1.476229485076816e-05 | -2.64217315185597e-05 | 0.000133748780202221 | 6.467790813708989e-05 |  | GGA | 0.3401077490378126 | 0.1360035404871225 |  | 0.497767186275428 | 0.3614544869536491
AGC | 4.52064605648242e-05 | 1.163242207425882e-05 | 9.95330234805026e-05 | 0.000268697463171496 | 8.018278214408901e-05 |  | AGC | 0.2372156150186453 | 0.1071683368021494 | 0.2698851822051132 | 1 | 0.4481039541504248
GGC | 4.50418100235631e-05 | 1.59848729450273e-05 | 7.21812548137618e-05 | 0.000154390063284333 | 6.57857108182676e-05 |  | GGC | 0.2363516305588932 | 0.147267029736058 | 0.195720479756368 | 0.5745869777184819 | 0.3676454764476545
AGG | 5.39502897128611e-05 | 1.121789995059835e-05 | 7.80078004228686e-05 | 0.000195123610105765 | 8.50142786112454e-05 |  | AGG | 0.2830978359015487 | 0.1033493860903546 | 0.2115192394880888 | 0.7261832985048595 | 0.4751049213593954
GGG | 5.85553743534234e-05 | 1.189613850623112e-05 | 6.16704981546096e-05 | 0.000115380469629184 | 8.07230901280206e-05 |  | GGG | 0.3072624789984674 | 0.1095979298156636 | 0.1672204163917242 | 0.4294066206183066 | 0.4511234820039695
AGT | 4.55868335455832e-05 | 1.481250874787509e-05 | 6.372879575822019e-05 | 0.000253757271807974 | 7.98711381462513e-05 |  | AGT | 0.2392115777514019 | 0.1364661560802425 | 0.1728015190685821 | 0.9443977208151518 | 0.4463623220445772
GGT | 4.4137883651092e-05 | 1.530842213583571e-05 | 7.48643050561247e-05 | 0.000143499881826687 | 5.97474475880741e-05 |  | GGT | 0.2316083826315349 | 0.1410349563392413 | 0.2029956079319672 | 0.534057449344426 | 0.3339004559170805
ATA | 5.32412703813058e-05 | 1.172739511565798e-05 | 7.68382070435597e-05 | 0.000258413232829333 | 8.907527349632549e-05 |  | ATA | 0.2793773398774502 | 0.1080433138983048 | 0.208347870717778 | 0.9617256142995324 | 0.4977999166829418
GTA | 5.59813323749608e-05 | 1.348380543941582e-05 | 8.19455453065316e-05 | 0.00021410343248531 | 6.97908030428413e-05 |  | GTA | 0.2937554947449836 | 0.1242249458866924 | 0.2221964896935226 | 0.7968197018244961 | 0.3900280580266213
ATC | 4.18344663382467e-05 | 1.274191579507557e-05 | 6.43684597027207e-05 | 0.000234303428899651 | 8.34482976927501e-05 |  | ATC | 0.2195214696619237 | 0.1173899910709948 | 0.1745359767809551 | 0.8719971753142565 | 0.4663533886370603
GTC | 3.9806831410412e-05 | 1.955507027668725e-05 | 5.37629656089878e-05 | 0.000263392666629362 | 7.9089304623808e-05 |  | GTC | 0.2088816925055175 | 0.1801588993438625 | 0.1457790315403331 | 0.9802573627621178 | 0.4419930212604684
ATG | 6.07653007698587e-05 | 1.154424239774458e-05 | 8.97286727369108e-05 | 0.000229552950723602 | 7.2345166803339e-05 |  | ATG | 0.31885880942272 | 0.1063559462946991 | 0.243300548338792 | 0.8543175213272852 | 0.404303198783906
GTG | 5.795459286589601e-05 | 1.246415324288912e-05 | 6.74379973599932e-05 | 0.000210745120060629 | 6.84336757656535e-05 |  | GTG | 0.3041099484027295 | 0.1148309925620244 | 0.1828590709757248 | 0.7843212123149857 | 0.3824437103283782
ATT | 5.03013182868689e-05 | 1.325640918439394e-05 | 7.68038747242572e-05 | 0.000216728739402865 | 8.0996061727627e-05 |  | ATT | 0.2639502850827675 | 0.1221299670172737 | 0.208254778154863 | 0.8065901956972998 | 0.4526489922180525
GTT | 3.8768848630271e-05 | 1.414619785702811e-05 | 6.97796671173878e-05 | 0.000216205019712857 | 6.58912761848305e-05 |  | GTT | 0.2034349992565109 | 0.1303275007331978 | 0.1892085412021813 | 0.8046410902467817 | 0.3682354317586733
CAA | 6.963699698911619e-05 | 1.537104411880275e-05 | 6.93011193498682e-05 | 0.000123764528306705 | 8.95905488553514e-05 |  | CAA | 0.3654119978080834 | 0.1416118863817543 | 0.1879109522521563 | 0.46060921768998 | 0.5006795489391644
TAA | 6.58015574129122e-05 | 1.467467206638908e-05 | 0.000189377823821723 | 6.22680605062158e-05 | 8.79676399044569e-05 |  | TAA | 0.3452859771781022 | 0.1351962805710076 | 0.5135006121636149 | 0.2317404108369763 | 0.4916098721497622
CAC | 4.97596543705161e-05 | 1.431297983740352e-05 | 7.43155841267117e-05 | 0.000133598795990516 | 8.03440338184335e-05 |  | CAC | 0.2611079670280995 | 0.131864046375309 | 0.2015077434741634 | 0.497208996369447 | 0.4490051141121394
TAC | 4.09628039090112e-05 | 1.539800599300853e-05 | 0.000364872841188952 | 6.72102272605341e-05 | 7.45479729138857e-05 |  | TAC | 0.2149475230034976 | 0.1418602834221348 | 0.9893578008837193 | 0.2501334641095483 | 0.4166136487579278
CAG | 5.58873044906578e-05 | 1.138714724667049e-05 | 5.50468900734431e-05 | 9.58664022375682e-05 | 8.526459100890829e-05 |  | CAG | 0.2932620944184561 | 0.1049086444384891 | 0.1492604106435712 | 0.3567819402015772 | 0.4765037999236744
TAG | 5.40735904043652e-05 | 9.741956600729623e-06 | 0.000252560355052228 | 4.0966076806485e-05 | 6.37912491131864e-05 |  | TAG | 0.2837448418604742 | 0.08975166817658967 | 0.6848209273418773 | 0.1524617178106308 | 0.3564993656174958
CAT | 6.04566129649328e-05 | 1.214039179462922e-05 | 6.8518884819042e-05 | 0.000120616326819286 | 7.5534563519642e-05 |  | CAT | 0.3172390062667254 | 0.1118482108413156 | 0.1857899124053107 | 0.4488926891814483 | 0.4221272408252698
TAT | 5.36705767227738e-05 | 1.308117667355138e-05 | 0.000332688019899615 | 5.94073641778643e-05 | 7.735947819425149e-05 |  | TAT | 0.2816300746978793 | 0.1205155674863094 | 0.9020882088009142 | 0.2210938781359003 | 0.4323258328398266
CCA | 0.000123059454993766 | 2.63534245098536e-05 | 8.22037592721946e-05 | 0.000101797631519591 | 8.88707279686354e-05 |  | CCA | 0.6457400985495407 | 0.2427914544135866 | 0.2228966404649348 | 0.3788559457095385 | 0.4966568076848404
TCA | 7.23958197894403e-05 | 8.888083069640721e-05 | 0.000112705132932781 | 8.12493169834864e-05 | 8.24431696719798e-05 |  | TCA | 0.3798885978145782 | 0.8188501705423461 | 0.3056015408089511 | 0.3023821513775478 | 0.4607361996534556
CCC | 5.17771674903711e-05 | 3.194784801868432e-05 | 8.96918981495918e-05 | 0.000132284370211605 | 7.10818052807135e-05 |  | CCC | 0.2716946311808552 | 0.2943323165814885 | 0.2432008335320671 | 0.4923171534640599 | 0.3972428639006306
TCC | 3.45189985018102e-05 | 0.0001085434599562202 | 0.000312595217390682 | 6.24882240415425e-05 | 7.147738548559229e-05 |  | TCC | 0.1811344077179567 | 1 | 0.847606294391904 | 0.2325597841675915 | 0.3994535760915756
CCG | 7.89243062892927e-05 | 2.120906593274168e-05 | 9.033733297399409e-05 | 0.000125704918406136 | 0.000100308044661174 |  | CCG | 0.4141460672305414 | 0.1953969952800116 | 0.2449509390658296 | 0.4678306855688656 | 0.5605746052188216
TCG | 8.10944982248366e-05 | 6.887815581420166e-05 | 0.0001303123418188 | 5.88107919825883e-05 | 8.28040033868179e-05 |  | TCG | 0.4255338956131758 | 0.634567534902452 | 0.3533437334216127 | 0.2188736405935189 | 0.4627527300117958
CCT | 8.66059387620426e-05 | 2.520918505848759e-05 | 8.66304886971115e-05 | 0.000130680625970014 | 8.481119938192179e-05 |  | CCT | 0.454454535281421 | 0.2322496912172823 | 0.234899779078025 | 0.486348566255749 | 0.4739700068149961
TCT | 5.74294069022032e-05 | 0.0001037866480173733 | 0.000236764749840856 | 6.96795116657139e-05 | 8.26117035785139e-05 |  | TCT | 0.3013540964775848 | 0.9561759691393152 | 0.6419909233749401 | 0.2593232955878001 | 0.4616780565946457
CGA | 7.04072189510565e-05 | 1.602950935394191e-05 | 8.866116719769389e-05 | 0.00011548692880663 | 0.000105386768030993 |  | CGA | 0.3694536474776154 | 0.1476782604903809 | 0.2404059921715823 | 0.4298028252426058 | 0.5889572076079784
TGA | 4.8172768052824e-05 | 1.197755090291253e-05 | 6.3748123471735e-05 | 4.43010418535311e-05 | 7.39100400524858e-05 |  | TGA | 0.2527809666588445 | 0.110347974053375 | 0.1728539264335063 | 0.1648733163708955 | 0.4130485412618808
CGC | 4.25642079138821e-05 | 1.670008252015644e-05 | 6.55938020149278e-05 | 0.000161816130269635 | 8.1721176760114e-05 |  | CGC | 0.2233507032384121 | 0.153856183752501 | 0.1778585095608262 | 0.6022242575708873 | 0.4567013199695072
TGC | 4.66619952660165e-05 | 1.451611723469687e-05 | 7.42564465321043e-05 | 6.35077292944074e-05 | 7.283851697695939e-05 |  | TGC | 0.2448533631415978 | 0.133735530823799 | 0.201347391061088 | 0.2363540338074336 | 0.4070603014644145
CGG | 6.06277411321648e-05 | 1.031713107144118e-05 | 9.41014560190216e-05 | 0.000101875289865897 | 8.95585686756408e-05 |  | CGG | 0.3181369813112158 | 0.09505069283402691 | 0.2551574112328155 | 0.3791449634970135 | 0.5005008267172664
TGG | 4.61989964224204e-05 | 1.137950939307701e-05 | 6.09489862622484e-05 | 4.09211693263631e-05 | 8.83042363116235e-05 |  | TGG | 0.2424238308565148 | 0.1048382776600894 | 0.1652640268264941 | 0.15229458753857 | 0.4934909515657038
CGT | 4.96148333621678e-05 | 1.567747735087292e-05 | 5.65688447194962e-05 | 0.00014829788360295 | 7.77597296434257e-05 |  | CGT | 0.2603480357232874 | 0.1444350249862706 | 0.1533872119060528 | 0.5519139699071106 | 0.43456265042377
TGT | 5.40524729829634e-05 | 1.435056192399945e-05 | 8.502968767196119e-05 | 7.56572725730749e-05 | 7.59492059153353e-05 |  | TGT | 0.2836340306613039 | 0.1322102863662867 | 0.2305591847582769 | 0.2815704758804763 | 0.4244444826582444
CTA | 6.90884355970904e-05 | 1.266420454568901e-05 | 0.000105218454588136 | 0.000131847235226885 | 0.000102124072372725 |  | CTA | 0.3625334860564657 | 0.1166740451317562 | 0.285301307996759 | 0.4906902866542271 | 0.5707235321658862
TTA | 5.48163826484866e-05 | 1.463861547105223e-05 | 6.51500325296093e-05 | 5.42496454219031e-05 | 9.27664417360311e-05 |  | TTA | 0.2876425572935962 | 0.1348640947778572 | 0.1766552224083394 | 0.2018986140828516 | 0.5184281243781331
CTC | 4.64927485051711e-05 | 1.177655079060336e-05 | 7.41594070774679e-05 | 0.000147212379577003 | 7.95692639065675e-05 |  | CTC | 0.2439652605570947 | 0.1084961801968843 | 0.2010842672256028 | 0.5478740954210081 | 0.4446752885338743
TTC | 3.74782523440032e-05 | 1.735719441630844e-05 | 7.641822096909469e-05 | 6.82382860126176e-05 | 8.03339173419977e-05 |  | TTC | 0.196662746176693 | 0.1599100896848993 | 0.207209072615731 | 0.2539595469461672 | 0.4489485778711693
CTG | 8.42228731123229e-05 | 1.829170833865196e-05 | 0 | 0.000140115027385508 | 0.000105245031793579 |  | CTG | 0.4419496769787576 | 0.1685196726364695 |  | 0.5214601795331416 | 0.5881651102682094
TTG | 7.71715457393381e-05 | 2.098003023518544e-05 | 0.000191012403092773 | 5.13594388645633e-05 | 0.000119052848629762 |  | TTG | 0.4049486612261123 | 0.1932869123911058 | 0.5179327966685139 | 0.1911422544089415 | 0.665330521058767
CTT | 6.50002940569608e-05 | 1.707469813791295e-05 | 0.000266651185156702 | 0.000136540745675752 | 0.000103046678209295 |  | CTT | 0.341081441423719 | 0.1573074798315794 | 0.7230284098153922 | 0.5081579262570296 | 0.5758795433747059
TTT | 4.12840577589075e-05 | 2.318332852583057e-05 | 0.000264001945700326 | 5.65220351435926e-05 | 9.642582829856e-05 |  | TTT | 0.2166332650109034 | 0.2135856783557601 | 0.7158449600578446 | 0.2103556709335861 | 0.538878719188967