Spreadsheet: 017b48d7-e079-4fb0-975e-477f7f8e346b
Sheet: Sheet1

Table S1. [NAME] targets Dataset
Key
[NAME] | Nodes are assigned a unique ID number in Cytoscape
Node label | Nodes are labelled by their protein names
Complex | If a protein complex was identified as playing a role in arenavirus infection, representative proteins of this complex were highlighted as viral targets.
Arenavirus protein | Arenavirus protein involved in viral-host protein-protein interaction,  or either responsible for, or targeted in, the phenotype described in Description and References
Description and References | Details on the role of the host target protein in virus infection or as identified by expression/ co-expression of viral proteins. Numbers in brackets refer to the primary study, as listed in the manuscript.
 | (v) refers to the identification of the phenotype in virus-infected cells or animal models. When a phenotype was identified using virus, but not during the course of an active infection, the technique used is indicated after the v denomination eg (v, VOPBA) (VOPBA=virus overlay protein blot assay)
 | (e) refers to the identification of the phenotype through expression of the viral protein(s) of interest, but not within the context of a virus infection, eg transient transfection of cells with an expression vector for an arenavirus protein
 | (ps) refers to the identification of the phenotype through the use of arenavirus GP-pseudotyped vectors.
[NAME] | Node label | Complex | Arenavirus protein | Description and References
95065 | ALIX |  | Z, NP | [NAME] protein interaction - MOPV Z and NP [46] (e). ALIX not required for LASV Z VLPs budding [64] (e), but required for cell entry by LCMV Cl13 (ps,v) and [NAME] (ps) [67]
175127 | PML |  | Z | [NAME] protein interaction - LCMV ARM, LASV Z [8] (e). Cytoplasmic redistribution of PML nuclear bodies can be observed upon LCMV infection or expression of LCMV Z [8, 11, 94] (v,e). PML levels decrease during LCMV infection [11](v).
4753 | [NAME] |  | Z | Protein-protein interaction - LCMV ARM Z [9, 10](e), LASV Z [47] (e). [NAME] is incorporated into LCMV virions [9](v). Z inhibits EIF4E-dependent translation by reducing [NAME] affinity for cap [10, 47] (e).
5033 | KRT1 |  | NP | Protein-protein interaction - LCMV MX NP [48](e). LCMV persistent infection stabilizes the keratin network against disassembly [48](v), intact keratin network is required for cell-cell transmission during persistent infection [48](v).
4855 | IKBKE |  | NP | Protein -protein interaction : LCMV ARM, LASV, JUNV, LATV, WWAV NP [49](e). LCMV NP colocalizes with IKBKE in infected cells [49](v). NP inhibits IKBKE kinase activity, and therefore downstream phosphorylation of IRF-3 [49](e).
104238 | TFRC |  | GP | Viral receptor : MACV, JUNV, GTOV, SABV, but not LCMV ARM and LASV [50](ps); MACV, GTOV, JUNV but not TCRV, AMAV [51](ps); MACV but not TCRV or WWAV [52](ps); JUNV XJ13 and JUNV Cd1 [53](ps). Host orthologs of hTfR-1 act as receptors for TCRV and AMAV [56](v)
33572 | DAG1 |  | GP | Viral receptor : LCMV (Cl13, ARM, WE54), LASV, MOBV, OLVV but not GTOV [54](v, VOPBA); [NAME], OLVV, Ippy but not AMAV or PARV [55](v, confirmed by VOPBA); OLVV, [NAME] but not PARV, PICV, AMAV, GTOV, JUNV, MACV [57] (ps); and not WWAV [52](ps); LCMV ARM53b exhibits lower affinity for alpha-dystroglycan than LCMV WE54 or LASV [55](v, VOPBA). LCMV infection interferes with expression of functional alpha-dystroglycan, perturbing DAG1-mediated assembly of laminin at the cell surface, and thus cell-matrix interactions [92](v).
120 | LARGE |  | GP | Protein-protein interaction - LASV GP [92](e). GP was found to associate with LARGE and DAG1 in the Golgi [92](e). Overexpression of LARGE restores expression of functional DAG1 in LCMV-infected cells [92](v).
75710 | AXL |  | GP | Viral receptor - LASV [59](ps), LCMV (Cl13, WE, ARM) [58](ps)
76626 | TYRO3 |  | GP | Viral receptor - LASV [59](ps), LCMV (Cl13, WE, ARM) [58](ps)
1165 | DCSIGN |  | GP | Viral receptor - LASV [59](ps), LCMV (Cl13, WE, ARM) [58](ps), expression of DCSIGN enhances JUNV IV4454 infection of NIH 3T3 cells [60](v)
12 | LSECtin |  | GP | Viral receptor - LASV [59](ps), LCMV (Cl13, WE, ARM) [58](ps)
95785 | LSIGN |  | _ | Expression of LSIGN enhances JUNV IV4454 infection of NIH 3T3 cells [60](v)
50028 | RPLP0 |  | Z | [NAME] protein interaction - LCMV ARM Z [11](e). Z co-precipitates with the nuclear but not cytoplasmic fraction of RPLP0 [11](e)
32967 | RIG-I |  | Z, NP | Protein-protein interaction - RIG-I - Z association : MACV, JUNV, GTOV, SABV but not LASV or LCMV ARM [61](e), New World arenavirus Z may block the RIG-I/MAVS complex formation, inhibiting downstream activation of NFKB and IRF3[61](e); NP : LCMV ARM [62](e), disputed in [49](e). NP-RIG-I association is controversial as a recently published study does not find evidence of RIG-I- NP association [49].
4413 | IFIH1 |  | NP | Protein-protein interaction - LCMV ARM NP [62] (e)
146558 | PRH |  | Z | Protein-protein interaction - LCMV-WE and and LCMV-ARM Z colocalize and interact with PRH [95, 96](v, e). Z alone does not decrease PRH levels, but PRH levels are decreased in hepatic cells and rhesus macaque livers when infected with LCMV-WE but not LCMV-ARM [95](v)
50767 | RPL10a |  | _ | Co-localization with virus-specific structures, detected with anti-NP antibody - JUNV Cd1, TCRV [108](v)
5212 | EIF4G |  | _ | Co-localization with virus-specific structures, detected with anti-NP antibody - JUNV Cd1, TCRV [108](v)
4197 | EIF4A |  | _ | Co-localization with virus-specific structures, detected with anti-NP antibody - JUNV Cd1, TCRV [108](v)
150432 | G3BP1 |  | _ | Co-localization with virus-specific structures, detected with anti-NP antibody - JUNV Cd1, TCRV [108](v)
196733 | RPS6 |  | _ | Co-localization with virus-specific structures, detected with anti-NP antibody - JUNV Cd1, TCRV [108](v)
77137 | TSG101 |  | Z | Required for Z budding - LCMV ARM [63](e), LASV [63, 64](e), but not TCRV [65](e), required for entry by LCMV Cl13  and LASV [67](ps). During LCMV entry, NP transiently colocalizes with Tsg101 before reaching the late endosomes [67](v)
95133, 94560, 57010, 57194, 57790, 57806, 95155, 94381, 94319, 58933, 57508 | PIK3C2A,PIK3C2B, PIK3C3,PIK3CA, PIK3CB, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R4, PIK3R6 | PI3K | Z, GP | Required for productive infection by LCMV Cl13 [66](v), JUNV [68](v). Required for LCMV Cl13 and LASV Z budding [66](e).  Required for LCMV and LASV entry [67](ps), but not LCMV ARM entry [66](ps). Role of the PI3K pathway identified through the use of the drugs wortmannin, LY294002 and BEZ235 [67-68](v). PI3K3C3 upregulated by [NAME], but not PICV P18 infection [14](v)
52868 | AKT1 |  | _ | Requirement for PI3K/[NAME] pathway for infection by LCMV Cl13 [66](v), and JUNV [68](v). Requirement identified through use of LY294002, which was found to prevent phosphorylation of [NAME] [66].
146118 | Hrs |  | _ | Required for entry - LCMV Cl13, rLCMV-LASVGP [67](v, [NAME]). Required for entry in A549 cells but not macrophages [67](v)
64062 | Vps22 |  | _ | Required for entry - LCMV Cl13, rLCMV-LASVGP [67](v, ps)
96548 | Vps24 |  | _ | Required for entry - LCMV Cl13, rLCMV-LASVGP [67](v,ps)
76055 | Vps4A |  | _ | Required for Z budding for LASV [64](e), and TCRV Z VLPs [65](e), required for entry for LCMV, LCMV-LASVGP [67](v,ps)
77321 | Vps4B |  | _ | Required for Z budding for LASV [64](e), and TCRV Z VLPs [65](e), required for entry for LCMV, rLCMV-LASVGP [67](v,ps)
1001 | ADAL |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
818798 | ARHGAP23 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
50483 | ATP6AP2 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
139685 | ATPIF1 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
139999 | BBC3 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
1002 | C14ORF111 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
834 | CARD14 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
96814, 96866, 96346, 96218, 95938, 97112 | COPA, COPB, COPB2, COPD, COPG, COPZ1 | Coatomer complex | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
32095 | DCAF13 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
32123 | DCD |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
14956 | EIF3A |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
14164 | EIF3G |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
14418 | EIF3S2 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
1003 | ERN2 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
184819 | FAU |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
150636 | FBL |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
151155 | FOXF2 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
150126 | FRS2 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
1005 | FAM167B |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
147135 | GRM2 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
150781 | GBF1 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
1006 | H1FOO |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
177027 | HNRPK |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
124737 | LAMC3 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
102348 | MAT2A |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
118779 | NHP2L1 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
118251 | NOL5A |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
118040 | NRL |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
57968 | PIWIL3 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
57396 | PPP1R15B |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
95039 | SLC46A1 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
64926 | SYVN1 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
1107 | CDK15 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
1008 | [NAME] |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
150315 | GABBR2 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
5590 | IFI35 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
1009 | LYSMD1 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
1011 | OR7A10 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
1100 | P2RY10 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
64435 | [NAME] |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
1101 | TAS2R48 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
1102 | [NAME] |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
75405 | UTP6 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
1104 | WDR46 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
71651 | ZNF446 |  | _ | Required for virus infection - LCMV ARM [69](v) - identified through siRNA screen
105075, 103417, 104949, 104935, 104220, 105123, 104004, 103886, 103425, 103471, 104128, 105115, 103896, 104592, 105097, 104433, 149891, 150697, 150943, 149917 | TUBAI, TUBA1A, TUBA1C, TUBA3C, TUBAE, TUBA4A, TUBA4B, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB6, TUBB8, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 | Tubulin | _ | Required for virus infection - JUNV replication [70, 71](v); intact microtubules required for entry by rLCMV-LASVGP [77](v), microtubule dynamics are essential for JUNV infection [72](v)
51946, 51704, 52282, 52421 | ACTA, ACTB, ACTC, ACTG | [NAME] | _ | Required for virus infection - JUNV replication [70, 71](v), JUNV entry [72](v), but not for rLCMV-LASVGP or LCMV entry [75-77](v), [NAME] expression levels - PICV P2, not P18 [13](v)
14620 | [NAME] |  | _ | Required for JUNV entry, but not rLCMV-LASVGP or LCMV Cl13 entry [76,77](v)
15486 | DNM2 |  | _ | Required for JUNV [74,77] but not rLCMV-LASVGP entry or LCMV Cl13 entry [76,77](v)
15204 | EPS15 |  | _ | Required for JUNV [74,77](v) but not rLCMV-LASVGP entry [77](v) or LCMV Cl13 entry [76](v)
50568, 50058, 50216 | RAB5A, RAB5B, RAB5C | Rab5 | _ | Required for JUNV entry [74](v), mild dependence on RAB5 for rLCMV-LASVGP entry [77](v)
49455 | [NAME] | [NAME] | _ | Required for JUNV entry [74](v), but not for rLCMV-LASVGP entry [77](v)
101230 | SKI-1 |  | _ | Required for cleavage of GP - LASV [79,80](e,v), LCMV [80](e), JUNV, MACV, GTOV [82](e), JUNV Cd1 [82](v). SKI-1 not required for cell surface expression of GP, but is required for virion infectivity [79,81](v). Arenavirus glycoproteins sequences mimic SKI-1 autoprocessing sites [83](e).
494080, 96658, 494085 | CLTA, CLTB, CLTC | Clathrin | _ | Clathrin-mediated endocytosis required for JUNV entry [73](v), but not LCMV [75](v) or rLCMV-LASVGP [77](v), clathrin heavy chain 2 downregulated in PICV P2 [14](v)
76676, 76319, 76518, 75562, 76558, 76269, 76885, 76113, 76925, 75800, 193245, 75756, 77045, 76231, 75860, 77369, 76447 | ATP6V1A, ATP6V1B1, ATP6V1C1, [NAME], ATP6V1E2, ATP6V1F, ATP6V1H, ATP6V1G1 ,ATP6V1G2, ATP6V1B2, ATP6V1E1, ATP6V1G3, ATP6V0A1, ATP6V0B, ATP6V0C, ATP6V0E1, ATP6V0D1, ATP6V0A4, ATP6V0E2, ATP6V0A2, ATP6V1C2, ATP6V0D2 | V-ATPase complex | _ | Required for virus infection - JUNV [78](v), ATP6V0B and ATP6V0D1 required for productive infection by LCMV ARM [69](v); change in expression levels - PICV P2, P18 [13](v)
1105 | BST-2 |  | _ | Inhibits virion release - LASV [109], MACV VLPs [109], LASV VLPs [110]
4501 | IRF3 |  | NP | Is inhibited by virus - LCMV [84](v); is inhibited by NP - LCMV,LASV, WWAV, PICV, JUNV, MACV, [NAME] but lesser inhibitory effect of TCRV [85](e)
155979, 228738, 104931, 49197, 50727 | NFKB1, [NAME], RelA, RelB, c-Rel | NF-κB | NP | Is inhibited by NP - LCMV, LASV, WWAV, PICV, JUNV, MACV, [NAME] but lesser inhibitory effect of TCRV [86](e).Is inhibited by JUNV Z [61](e). RelA is upregulated in PICV infected cells [14](v). Differential NF-κB dimer formation in PICV-infected cells: formation of both p65/p50 and p50 homodimers complexes in avirulent P2 strain, but only p50 homodimers detected in virulent P18 strain infection [89](v). Activity of a NF-KB dependent reporter was induced by infection with LCMV-ARM, but not by infection with LCMV-WE or LCMV Cl13 [90](v)
145644 | HNRPD |  | _ | Differential expression levels - PICV P2, P18 [13](v)
50095 | HNRNPA2/B1 |  | _ | Differential expression levels - PICV P2, P18 [13](v)
145385 | HNRPL |  | _ | Differential expression levels - PICV P2, P18 [13](v)
50148 | UQCRC1 |  | _ | Differential expression levels - PICV P2, P18 [13](v)
31865 | DLG4 |  | _ | Upregulated - PICV P2, P18 [14](v)
139915 | BCAR1 |  | _ | Upregulated - PICV P2, P18 [14](v)
15914 | EDNRA |  | _ | Upregulated - PICV P2, P18 [14](v)
1482 | [NAME] |  | _ | Upregulated - PICV P2, P18 [14](v)
151260 | FAS |  | _ | Upregulated - PICV P2, P18 [14](v)
32675 | DCTN1 |  | _ | Upregulated - PICV P2, P18 [14](v)
139124 | DDEF1/ASAP1 |  | _ | Upregulated - PICV P2, P18 [14](v)
63215 | TJP2 |  | _ | Upregulated - PICV P2, P18 [14](v)
102703 | MSN |  | _ | Upregulated - PICV P2, P18 [14](v)
140332 | BTK |  | _ | Upregulated - PICV P2, P18 [14](v)
102124 | LYN |  | _ | Upregulated - PICV P2, P18 [14](v)
57932 | PTEN |  | _ | Upregulated - PICV P2, P18 [14](v)
102256 | MAPK8 |  | _ | Upregulated - PICV P2, P18 [14](v)
32233 | CK2 |  | _ | Upregulated - PICV P2, P18 [14](v)
63491 | SUPT5H |  | _ | Upregulated - PICV P2, P18 [14](v)
63900 | STRN3 |  | _ | Upregulated - PICV P2, P18 [14](v)
140742 | STK6 |  | _ | Upregulated - PICV P2, P18 [14](v)
64552 | STAT1 |  | _ | Upregulated - PICV P2, P18 [14](v)
63675 | STAT3 |  | _ | Upregulated - PICV P2, P18 [14](v)
51622 | MLLT4 |  | _ | Upregulated - PICV P2, P18 [14](v)
424 | CBL |  | _ | Upregulated - PICV P2, P18 [14](v)
15526 | TCEB3 |  | _ | Upregulated - PICV P2, P18 [14](v)
118104 | NR4A2 |  | _ | Upregulated - PICV P2, P18 [14](v)
149331 | FEN1 |  | _ | Upregulated - PICV P2, P18 [14](v)
104614 | TGFI1 |  | _ | Upregulated - PICV P2, P18 [14](v)
150496 | FEZ1 |  | _ | Upregulated - PICV P2, P18 [14](v)
87394 | SHIP |  | _ | Upregulated- [NAME], not P18 [14](v)
539920 | HSP90 |  | _ | Upregulated- [NAME], not P18 [14](v)
64610 | SPTC1 |  | _ | Upregulated - PICV P2, P18 [14](v)
118791 | NLN |  | _ | Upregulated- PICV P, not P18 [14](v)
63663 | STAT5A |  | _ | Upregulated - PICV P2, P18 [14](v); differential phosphorylation PICV P2 [15](v)
64239 | SRPK2 |  | _ | Upregulated - PICV P2, P18 [14](v)
57162 | PLEK2 |  | _ | Upregulated - PICV P2, P18 [14](v)
57812 | PLCB1 |  | _ | Upregulated- [NAME], not P18 [14](v)
76528 | UBC9 |  | _ | Upregulated - PICV P2, P18 [14](v)
72401 | XPA |  | _ | Upregulated- [NAME], not P18 [14](v)
98 | CD9 |  | _ | Upregulated- [NAME], not P18 [14](v)
52956 | 4EBP1 |  | _ | Upregulated- [NAME], not P18 [14](v)
5718 | [NAME] |  | _ | Upregulated- [NAME], not P18 [14](v)
1007 | IGTP |  | _ | Upregulated - PICV P2, P18 [14](v)
228251 | STK3 |  | _ | Upregulated- [NAME], not P18 [14](v)
15732 | E2F1 |  | _ | Upregulated- [NAME], not P18 [14](v)
64026 | SOD2 |  | _ | Downregulated - PICV P2, not P18 [14](v)
51389 | AMPKb |  | _ | Downregulated - PICV P2, not P18 [14](v)
124949 | LCP2 |  | _ | Downregulated - PICV P2, not P18 [14](v)
118094 | MXI1 |  | _ | Downregulated - PICV P2, not P18 [14](v)
58444 | PRP17 |  | _ | Downregulated - PICV P2, P18 [14](v)
145918 | HRK |  | _ | Downregulated - PICV P2, not P18 [14](v)
101740 | MEF2D |  | _ | Downregulated - PICV P2, not P18 [14](v)
33376 | CTDSL |  | _ | Downregulated - PICV P2, not P18 [14](v)
49414 | RAB11 |  | _ | Downregulated - PICV P2, not P18 [14](v)
124515 | KATNB1 |  | _ | Downregulated - PICV P2, not P18 [14](v)
33592 | CYBB |  | _ | Downregulated - PICV P2, not P18 [14](v)
95829 | HSP60 |  | _ | Differential expression levels [13, 14](v)
4171 | PRKAR1B |  | _ | Downregulated - PICV P2, P18 [14](v)
14668 | E2AK2 |  | _ | Downregulated - PICV P2, not P18 [14](v)
118377 | NEK3 |  | _ | Downregulated - PICV P2, not P18 [14](v)
103523 | TIAR |  | _ | Downregulated - PICV P2, P18 [14](v)
4409 | i-CAM1 |  | _ | Upregulated - JUNV P3441, JUNV XJ44 [87](v)
75744 | v-CAM1 |  | _ | Upregulated - JUNV P3441, JUNV XJ44 [87](v)
32199 | DAF |  | _ | Upregulated - JUNV P3441, JUNV XJ44 [87](v), greater increase for JUNV P3441 than JUNV XJ44 [87](v)
104206 | TNFA |  | _ | Upregulated in AHF patients [94](v) and LCMV-ARM [107](v), produced in response to TCRV but JUNV (Romero strain) in monocytes and macrophages [103](v), TNFA not upregulated in [NAME] fever patients [105](v). adPICV but not PICV 3739 resulted in upregulation of TNF-alpha levels [93](v).
76425 | VWF |  | _ | Downregulated - JUNV P3441, JUNV XJ44 [87](v), upregulated in AHF patients [88](v)
15878 | DTNA |  | _ | Downregulated - PICV P2, P18 [14](v)
15576 | DTNB |  | _ | Downregulated - PICV P2, P18 [14](v)
52629 | ANXA4 |  | _ | Downregulated - PICV P2, P18 [14](v)
150801 | FHIT |  | _ | Downregulated - PICV P2, P18 [14](v)
544314 | GNB2L1 |  | _ | Downregulated - PICV P2, P18 [14](v)
5882 | [NAME] |  | _ | Downregulated - PICV P2, P18 [14](v)
102266 | MSH6 |  | _ | Downregulated - PICV P2, P18 [14](v)
72143 | XRCC4 |  | _ | Downregulated - PICV P2, P18 [14](v)
101998 | CDC25B |  | _ | Downregulated - PICV P2, P18 [14](v)
96780 | CHEK2 |  | _ | Downregulated - PICV P2, P18 [14](v)
32761 | [NAME] |  | _ | Downregulated - PICV P2, P18 [14](v)
72469 | XPO1 |  | _ | Downregulated - PICV P2, P18 [14](v)
64095 | SMARCD1 |  | _ | Downregulated - PICV P2, P18 [14](v)
93464 | TP53 |  | _ | Downregulated - PICV P2, P18 [14](v)
65233 | STMN1 |  | _ | Downregulated - PICV P2, P18 [12](v). Downregulation of stathmin was more pronounced in P2 -infected cells than P18 [12](v). Differential phosphorylation [NAME], P18 [15](v)
49891 | [NAME] |  | _ | Downregulation of protein levels - LCMV [11](v).
50615 | RPLP2 |  | _ | Downregulation of protein levels - LCMV [11](v).
57330 | PTMA |  | _ | Altered secretion - PICV [12](v)
124392 | LGALS3 |  | _ | Upregulation of protein levels - JUNV [96](v); differential phosphorylation - PICV P2, P18 [15](v)
102867 | MAPK10 |  | _ | Downregulated - PICV P2, not 18 [14](v)
64163 | SRP54 |  | _ | Downregulated - PICV P2, not 18 [14](v)
50032 | RANBP3 |  | _ | Downregulated - PICV P2, not 18 [14](v)
430274 | NUTF2 |  | _ | Downregulated - PICV P2, not 18 [14](v)
101478 | MTX-1 |  | _ | [NAME], upregulated PICV P18 [14](v)
146560 | HMOX1 |  | _ | Downregulated - PICV P2, not 18 [14](v)
1108 | ZFP37 |  | _ | Downregulated - PICV P2, P18 [14](v)
73107 | XRCC6 |  | _ | Downregulated - PICV P2, P18 [14](v)
14620 | [NAME] |  | _ | Downregulated - PICV P2, P18 [14](v)
33108 | CTBP1 |  | _ | Downregulated - PICV P2, not 18 [14](v)
534616 | FAK |  | _ | Downregulated - PICV P2, P18 [14](v)
50218 | RAC1 |  | _ | Downregulated - PICV P2, not 18 [14](v)
64503 | STX11 |  | _ | Downregulated - PICV P2, P18 [14](v)
145948 | GRP78 |  | _ | Downregulated - PICV P2, not 18 [14](v)
14216 | EPM2A |  | _ | Downregulated - PICV P2, P18 [14](v)
63563 | SNCA |  | _ | Downregulated - PICV P2, P18 [14](v)
50903 | RAB8A |  | _ | Downregulated - PICV P2, P18 [14](v)
4981 | ITCH |  | _ | Downregulated - PICV P2, not 18 [14](v)
1010 | CALB2 |  | _ | Downregulated - PICV P2, not 18 [14](v)
1790 | CASP6 |  | _ | Downregulated - PICV P2, not 18 [14](v)
1742 | CDC37 |  | _ | Upregulated - PICV P18, not P2 [14](v)
547739 | SNAPIN |  | _ | Upregulated - PICV P18, not P2 [14](v)
138889 | GOLIM3 |  | _ | Upregulated - PICV P18, not P2 [14](v)
145824 | GSK3B |  | _ | Upregulated - PICV P18, not P2 [14](v)
57068 | PKN2 |  | _ | Upregulated - PICV P18, not P2 [14](v)
57142 | PPME1 |  | _ | Upregulated - PICV P18, not P2 [14](v)
13968 | POLD1 |  | _ | Upregulated - PICV P18, not P2 [14](v)
124077 | PRKCA |  | _ | Upregulated - PICV P18, not P2 [14](v)
117660 | NLRP2 |  | _ | Upregulated - PICV P18, not P2 [14](v)
71531 | ZNF148 |  | _ | Upregulated - PICV P18, not P2 [14](v)
118334 | NCK1 |  | _ | Upregulated - PICV P18, not P2 [14](v)
50791 | RBBP9 |  | _ | Downregulated - PICV P18, not P2 [14](v)
102407 | [NAME] |  | _ | Downregulated - PICV P18, not P2 [14](v)
139530 | ARRB1 |  | _ | Downregulated - PICV P18, not P2 [14](v)
51630 | AIMP1 |  | _ | Downregulated - PICV P18, not P2 [14](v)
14050 | ERCC2 |  | _ | Downregulated - PICV P18, not P2 [14](v)
145607 | HSF4 |  | _ | Downregulated - PICV P18, not P2 [14](v)
49935 | PTPRT |  | _ | Downregulated - PICV P18, not P2 [14](v)
95900 | COX7A2L |  | _ | Downregulated - PICV P2, not [NAME])
5818, | CAMK2A |  | _ | Upregulated - PICV P2, not P18 [14](v); differential phosphorylation - PICV P2, P18 [15](v)
145401 | GRIA2 |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
288 | CFTR |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
58 | [NAME] |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
102226 | MARCKS |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
14516 | EGFR |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
139422 | BLK |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
117998 | NCF1 |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
146903 | [NAME] |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
161395 | NPM1 |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
101374 | MGP |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
87720 | SCN2A1 |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
33498 | CSF1R |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
123691 | KIT |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
4293 | IL1R1 |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
279819 | RET |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
5254 | INSR |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
58546 | PDGFRB |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
76470 | VIM |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
51618 | ACACA |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
124565 | PKLR |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
104443 | MAPT |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
93700 | PCYT1A |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
49765 | RAB4A |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
65333 | SRF |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
123583 | LMNA |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
123278 | LMNB1 |  | _ | Differential phosphorylation - PICV P2, P18 [15](v)
150795 | FGA |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
139731 | ATP1A1 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
93992 | PLA2G4A |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
102504 | MBP |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
97098 | COL1A2 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
64085 | SYN1 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
51526 | ANXA1 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
52180 | ANXA2 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
145991 | GRIK2 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
146086 | GLRA1 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
117478 | MPZ |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
64872 | STOM |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
139643 | ATP2B1 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
52787 | HLAB |  | _ | Differential phosphorylation - PICV P2, not P18 [14](v); upregulation in LASV-infected monkeys [106](v)
15798 | ERBB2 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
14460 | [NAME] |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
101498 | MET |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
52743 | ADRB2 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
57936 | PLCG1 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
123557 | PRKCD |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
49536 | RASA1 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
94576 | PXN |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
1057 | CALD1 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
146689 | HMGCR |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
87366 | S100A9 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
52394 | YWHAQ |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
145852 | [NAME] |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
145999 | HS90A |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
76805 | TH |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
117313 | NFM |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
94223 | PDHA1 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
14434 | [NAME] |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
1369 | CDK2 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
49714 | RB1 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
4091 | JUN |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
145616 | HCLS1 |  | _ | Differential phosphorylation - PICV P2, not P18 [15](v)
51658 | AGT |  | _ | Differential phosphorylation - PICV P18, not P2 [15](v)
4871 | ITPR1 |  | _ | Differential phosphorylation - PICV P18, not P2 [15](v)
1013 | PKIR |  | _ | Differential phosphorylation - PICV P18, not P2 [15](v)
76177 | VTN |  | _ | Differential phosphorylation - PICV P18, not P2 [15](v)
14726 | ENO1 |  | _ | Differential phosphorylation - PICV P18, not P2 [15](v), differential expression levels [NAME], not P18 [13](v)
58346 | PDC |  | _ | Differential phosphorylation - PICV P18, not P2 [15](v)
52535 | ACO1 |  | _ | Differential phosphorylation - PICV P18, not P2 [15](v)
140260 | ATF2 |  | _ | Differential phosphorylation - PICV P18, not P2 [15](v)
51119 | GOT2 |  | _ | Differential expression levels - PICV P2, not P18 [13](v)
104358 | VCP |  | _ | Differential expression levels - PICV P2, not P18 [13](v)
146848 | HSPA6 |  | _ | Differential expression levels - PICV P2, not P18 [13](v)
146490 | HSPA8 |  | _ | Differential expression levels - PICV P2, not P18 [13](v)
117054 | NONO |  | _ | Differential expression levels - PICV P2, not P18 [13](v)
104012 | TARDBP |  | _ | Differential expression levels - PICV P2, not P18 [13](v)
147227 | HBD |  | _ | Differential expression levels - PICV P2, not P18 [13](v)
76101 | UQCRFS1 |  | _ | Differential expression levels - PICV P2, not P18 [13](v)
101912 | MAPRE1 |  | _ | Differential expression levels - PICV P18, not P2 [13](v)
4963 | IDH3A |  | _ | Differential expression levels - PICV P18, not P2 [13](v)
57246 | PHB |  | _ | Differential expression levels - PICV P18, not P2 [13](v)
50022 | RBM3 |  | _ | Differential expression levels - PICV P18, not P2 [13](v)
140300, 140556 | ATP5A1, ATP5B | Mitochondrial F1-F0 ATP synthase | _ | Differential expression levels - ATP5A1: [NAME], P18 [13](v); ATP5B: PICV P18, not P2 [13](v)
118711 | NOS3 |  | _ | Upregulated- JUNV P3441, not JUNV XJ44 [87](v)
5890 | IL6 |  | _ | Upregulated - JUNVv (AHF patients) [94](v); upregulated - TCRV, not JUNV in macrophages/ monocytes [103](v); upregulated in LASV-infected monkeys in terminal stages [106](v)
5464 | IL8 |  | _ | Upregulated - JUNVv (AHF patients) [94](v) and LASV (HF patients) [105](v), but not in LASV-infected monkeys [106](v)
4227 | IL10 |  | _ | Upregulated - JUNVv (AHF patients) [94](v); Upregulated - TCRV, not JUNV in macrophages/ monocytes [103](v)
5136 | IFNB |  | _ | Produced in macrophages and monocytes upon infection with JUNV Cd1 [98, 99](v), but not [NAME] strain [98, 103](v) or TCRV [103](v). Both viruses are insensitive to IFN [98](v).
52262 | A1AT |  | _ | Upregulated - JUNVv (AHF patients) [94](v)
103954 | TLR2 |  | _ | Activated by both JUNV Parodi and Cd1 strains GP [99](v), activated and upregulated by LCMV ARM [107](v)
4905 | IFNA |  | _ | No effect on IFN-alpha during infection of macrophages by TCRV or JUNV (Romero strain) [103](v). [NAME] detected in guinea pigs upon infection with JUNV XJ13 strain [100](v), and lower levels for MC2 strain [101](v). High levels of IFN-alpha found in AHF patients [102](v). Upregulation of IFN-alpha levels in LASV-infected monkeys [106](v)
14646 | EPO |  | _ | Differential expression levels of erythropoietin in AHF patients [104](v)
103924 | [NAME] |  | _ | Increase in thrombopoietin in AHF patients [104](v)
33458 | G-CSF |  | _ | Correlation between G-CSF and TNF-alpha levels in AHF patients [104](v)