Spreadsheet: e46ca93d-22cf-4c7a-a2c5-755765d685d0
Sheet: Sheet1

Table S8
Figure 5C -Genes with Steady, sustained induced temporal profile
 |  |  | Time
 |  |  | 2hr | Day 2 | Day 4 | Day 6 | Day 8 | Day 10 | Day 12 | Day 14
Gene | Common | Synonym | Ratio | Ratio | Ratio | Ratio | Ratio | Ratio | Ratio | Ratio | Description (Tuberculist annotation)
MT1627 |  |  | 0.92104495 | 1.0010988 | 1.1626757 | 1.2620419 | 1.2460926 | 1.2963293 | 1.5002682 | 1.5884054 | hypothetical protein
MT1802 |  |  | 0.7491251 | 0.67644006 | 0.75799346 | 0.75841975 | 0.7973938 | 0.80380607 | 0.9043503 | 0.9739946 | membrane protein, MmpL family
MT3204 |  |  | 1.0515921 | 1.0268098 | 1.0407678 | 1.0800567 | 1.1865561 | 1.1493355 | 1.3442239 | 1.4707258 | hypothetical protein
MT3248 |  |  | 0.82179594 | 0.7655975 | 0.87058455 | 0.93576634 | 0.8837458 | 0.95445323 | 1.1385381 | 1.0989583 | PPE family protein
[NAME] |  |  | 0.98404545 | 1.1578269 | 1.0883456 | 1.1256297 | 1.1652656 | 1.2152405 | 1.318039 | 1.4462771 | PE_PGRS family prote
MT4041.2 |  |  | 1.0448762 | 1.0137312 | 1.045221 | 1.162776 | 1.2377629 | 1.206308 | 1.2355403 | 1.3502117 | Hypothetical protein
Rv0024 | Rv0024 |  | 0.8021125 | 0.7903641 | 0.8587096 | 0.85563374 | 0.84468746 | 0.8685467 | 0.93636405 | 0.94754803 | Rv0024, (MTCY10H4.24), len: 281, similar to eg [NAME] protein p60 precursor (invasion-associated protein) (524 aa), [NAME] scores, opt: 245, E(): 1.5e-08, (37.0% identity in 100 aa overlap). Also similar to C.acetobutylicum Q45834 starch degrading enzyme E(): 1.7e-09. Similar to MTV021_23 E(): 1.8e-11, and [NAME] , E(): 9.8e-10.
Rv0094c | Rv0094c |  | 1.1643461 | 1.1247164 | 1.2560034 | 1.5083234 | 1.4742373 | 1.5477638 | 1.609146 | 1.818721 | Rv0094c, (MTCY251.13c), member of 13E12 repeat family, len: 317, also some similarity to gp|U15187|MLU15187_7 Mycobacterium leprae cosmid L296. (94 aa); 49.4% identity in 79 aa overlap
Rv0167 | Rv0167 | yrbE1A | 0.76247656 | 0.7230671 | 0.78345513 | 0.82807463 | 0.795605 | 0.866108 | 0.95226663 | 0.93211246 | Rv0167, (MTCI28.07), unknown, len: 265 aa; some similarity to several other hypothetical proteins eg. [NAME] [NAME] hypothetical protein hi1086 (261 aa), [NAME] scores opt: 328 z-score: 403.9 E(): 1.8e-15, 26.6% identity in 244 aa overlap. Also similar to downstream ORF MTCI28.08 (31.5% identity in 178 aa overlap) and to MTCY19H5_35
Rv0290 | Rv0290 |  | 0.70162386 | 0.676385 | 0.7862742 | 0.8390928 | 0.8296589 | 0.8387762 | 0.86059403 | 0.95071656 | Rv0290, (MTV035.18), len: 472. Hydrophobic protein unknown but similar to several others in mycobacteria e.g. MTCY77.20 (467 aa) and MLCB628.10c (480 aa). FASTA scores: Z95389|MTCY77_20 Mycobacterium tuberculosis cosmid (467 aa) opt: 429 z-score: 476.1 E(): 5.1e-19; 28.6% identity in 479 aa overlap; and Y14967|MLCB628_9 (480 aa) opt: 269z-score: 300.6 E(): 3.1e-09; 26.0% identity in 503 aa overlap. TBparse score is 0.892
Rv0335c | Rv0335c | PE6 | 1.0026969 | 1.0154753 | 1.0791401 | 1.1399083 | 1.2112697 | 1.1766686 | 1.3847423 | 1.3678539 | Rv0335c, (MTCY279.02c), len: 171. unknown, containsshort region of similarity to part of the unique N-terminusof the M. tuberculosis PGRS family of Glycine-rich proteinseg. Y03A_MYCTU Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), [NAME] scores; opt: 219 z-score: 280.8 E():1.1e-08, 51.5% identity in 66 aa overlap
[NAME] | Rv0509 |  | 0.85137695 | 0.88778305 | 0.89084446 | 0.9603017 | 0.9349408 | 0.99100286 | 0.9842176 | 0.9985979 | Rv0509, (MTCY20G9.36), len: 468,hemA, glutamyl-trna reductase, highly similar to HEM1_MYCLE P46724 (467 aa) FASTA scores, opt: 2377 z-score: 2571.8 E(): 0, (82.3% identity [NAME] aa overlap); contains PS00747 Glutamyl-tRNA reductase signature
Rv0513 | Rv0513 |  | 0.91086614 | 0.9559833 | 0.9283246 | 1.0196416 | 1.0352288 | 1.0652684 | 1.1054176 | 1.121707 | Rv0513, (MTCY20G10.03), len: 182, unknown, possiblemembrane protein, similar to, but longer than, M. leprae U00018_12 hypothetical protein TR:Q49831 B2168_C1_182 (103 aa), [NAME] scores; opt: 217 z-score: 372.7 E(): 8.2e-14, 45.3% identity in 106 aa overlap
[NAME] | Rv0527 | ccdA | 0.7394133 | 0.73531467 | 0.7659553 | 0.7802794 | 0.77155393 | 0.79821765 | 0.81548214 | 0.9079453 | Rv0527, (MTCY25D10.06), len: 259, [NAME], similar to CCDA_BACSU P45706 cytochrome c-type biogenesis protein (235 aa) opt: 307 z-score: 356.5 E(): 7.4e-13 (30.4% identity in 237aa overlap), highly similar to M. leprae Q49810 Q49810 B2168_C1_192 (262 aa), [NAME] scores, opt: 1341 z-score: 1519.2E(): 0, (79.0% identity in 262 aa overlap)
Rv0557 | Rv0557 | pimB;mtfB | 0.94821167 | 0.9824714 | 0.92098683 | 1.1092002 | 1.0722477 | 1.1532017 | 1.3089675 | 1.3702254 | Rv0557, (MTCY25D10.36), len: 378 aa, similar to SYNECHOCYSTIS SP. Q55598 hypothetical 44.9 [NAME] protein (409 aa), [NAME] scores, opt: 703 z-score: 799.6 E(): 0, (33.9% identity in 378 aa overlap) and to GPI3_YEAST P32363 n-acetylglucosaminyl-phosphatidylinositol BIOSYNTHETIC PROTEIN (452 aa), [NAME] scores,opt: 230 z-score: 263.9 E(): 1.1e-07, (23.5% identity in 328 aa overlap)
Rv0804 | Rv0804 |  | 0.7603232 | 0.84463286 | 0.846874 | 0.9106868 | 0.95588654 | 0.90613186 | 1.0025793 | 1.095351 | Rv0804, (MTCY07H7A.05c), len: 209 aa; unknown; contains PS01151 Fimbrial biogenesis outer membrane usher protein signature, some similarity to MTCY359.10 (256 aa), fastascores, opt: 199, E(): 1.2e-05, (33.2% identity in 220 aa overlap)
Rv0832 | Rv0832 | PE_PGRS12 | 0.92610896 | 0.8762161 | 0.902131 | 0.9364163 | 0.96671444 | 0.95170635 | 1.0028228 | 1.0307506 | Rv0832, (MTV043.24), len: 137. Member of Mycobacterium tuberculosis PE family, possibly PGRS subfamily, similar to many others e.g. MTCY1A11.25c (498 aa). Appears to have incurred frameshift as next orf should be continuation, sequence has been checked but no error found. FASTA scores: [NAME] (498 aa) opt: 529 z-score: 529.9 E(): 5.2e-22; 61.8% identity in 136 aa overlap. TBparse score is 0.875
pstC | Rv0935 | pstC1 | 0.80369437 | 0.8025498 | 0.9163013 | 0.96980643 | 0.94915 | 0.9319336 | 1.0711397 | 1.0687624 | Rv0935, (MTCY08D9.04c), pstC, len: 338. Probable PstC component of phosphate uptake system. Contains binding-protein-dependent transport systems inner membrane comp signature (PS00402). [NAME] scores: P45191 PSTC_HAEIN PHOSPHATETRANSPORT SYSTEM permease (315 aa) opt: 667; E(): 0; (36.2%identity in 309 aa overlap). Also similar to MTCY21C12.23,(324 aa).FASTA score: opt: 487; E(): 4.1e-21; (32.3% identity in 303 aa overlap). Slight similarity to MTCY08D9.03c
Rv0960 | Rv0960 |  | 0.84660906 | 0.8672665 | 0.9601424 | 1.0583395 | 1.0331175 | 1.0387788 | 1.1034408 | 1.1459342 | Rv0960, (MTCY10D7.14c), len: 127. Similar to otherM. tuberculosis hypothetical proteins e.g. MTV030.08, fastascores; E(): 1.5e-14, 38.3% identity in 128 aa overlap
Rv1006 | Rv1006 |  | 1.2111565 | 1.4656303 | 1.3916379 | 1.4535117 | 1.4553703 | 1.4819043 | 1.8146746 | 1.9929372 | Rv1006, (MTCI237.23), len: 567 aa. Unknown.
coaA | Rv1092c |  | 0.86682856 | 0.8071333 | 0.8712044 | 0.89484304 | 0.8936662 | 0.9150905 | 1.0094792 | 1.053564 | Rv1092c, (MTV017.45c), [NAME], len: 312. Probable pantothenate kinase similar to many e.g. P15044|COAA_ECOLI (316 aa). Contains PS00017 [NAME]/GTP-binding site motif A (P-loop). FASTA scores: sp|P15044|COAA_ECOLI PANTOTHENATE KINASE(EC 2.7.1.33) (316 aa) opt: 1079 z-score: 1353.6 E(): 0; 52.7% identity in 311 aa overlap. TBparse score is 0.912
Rv1134 | Rv1134 |  | 0.81207526 | 0.73062074 | 0.8254171 | 0.85172814 | 0.88935417 | 0.8585164 | 0.9797771 | 1.0378217 | Rv1134, (MTCI65.01), len: 78. TBparse score is 0.838
narJ | Rv1163 |  | 0.897602 | 0.96822095 | 1.0020938 | 1.0610272 | 1.0718462 | 1.0545576 | 1.0856423 | 1.192615 | Rv1163, (MTCI65.30), narJ, len: 201. Probable respiratory nitrate reductase delta chain (EC 1.7.99.4). FASTA scores: NARJ_BACSU NITRATE REDUCTASE DELTA CHAIN, P42178, (184 aa) opt: 254; E(): 1.9e-10; 31.8% identity in 179 aa overlap. Strong similarity to region 260 - 410 of MTCY04C12.21c, 64.8%identity in 159 aa overlap. TBparse score is 0.892
Rv1209 | Rv1209 |  | 0.9027821 | 0.8883948 | 0.93256545 | 0.91665846 | 0.97774005 | 0.99919873 | 0.99585295 | 1.0025676 | Rv1209, (MTCI364.21), len: 122. similar to Q49956U1756M (114 aa), [NAME] scores, opt: 524, E(): 8.9e-29, (78.6%identity in 112 aa overlap)
Rv1216c | Rv1216c |  | 0.880883 | 0.8902461 | 0.8915152 | 0.90835416 | 0.9106382 | 0.95495194 | 1.0190315 | 1.0563372 | Rv1216c, (MTCI364.28c), len: 224. c-terminal regionsimilar to M. [NAME] U1756P (134 aa), [NAME] scores,opt: 311, E(): 3.3e-15, (52.2% identity in 113 aa overlap)
glgP | Rv1328 |  | 0.76553684 | 0.7415362 | 0.77672994 | 0.8543393 | 0.8280078 | 0.8432036 | 0.9197371 | 0.99145776 | Rv1328, (MTCY130.13), glgP, len: 863. Probable glycogen phosphorylase, similar to many e.g. PHSG_HAEIN P45180glycogen phosphorylase (ec 2.4.1.1) (821 aa), [NAME] scores;E(): 6.9e-08, 25.6% identity in 675 aa overlap
Rv1396c | Rv1396c | PE_PGRS25 | 0.93002045 | 0.9027902 | 0.9650765 | 1.073073 | 1.0470022 | 1.1432147 | 1.1870703 | 1.4027789 | Rv1396c, (MTCY21B4.13c), len: 576. Member of the PEfamily, PGRS subfamily of M. tuberculosis proteins, strongsimilarity to many e.g. glycine rich protein eg MTCY130.10C,E245019 hypothetical 49.6 kDa protein (603 aa), [NAME] scores, opt: 1945, E(): 0, (57.5% identity in 619 aa overlap); contains PS00017 [NAME]/GTP-binding site motif A, similar toother PGRS-type sequences
Rv1397c | Rv1397c |  | 1.1717035 | 1.2823524 | 1.3339214 | 1.4917593 | 1.4401438 | 1.6056143 | 1.7768977 | 1.9064642 | Rv1397c, (MTCY21B4.14c), len: 133. Similar to M. tuberculosis protein MTCY159.08C,[NAME], [NAME] scores; E(): 2.3e-14, 42.4% identity in 125 aa overlap
ribC | Rv1412 |  | 0.8829351 | 0.8682006 | 0.97993165 | 1.0169597 | 1.0679566 | 1.0351841 | 1.1346031 | 1.1136522 | Rv1412, (MTCY21B4.29), ribC, len: 201. [NAME] synthase alpha chain, strong similarity to eg [NAME] (215 aa), [NAME] scores, opt: 586, E(): 1.8e-33, (50.8%identity in 197 aa overlap); contains 2 x PS00693 Riboflavinsynthase alphachain family signature
lipO | Rv1426c |  | 0.74191123 | 0.8279922 | 0.9197055 | 0.9764264 | 1.0149984 | 0.96123624 | 1.1202109 | 1.1105955 | Rv1426c, (MTCY493.28), len: 420. Unknown, possibleesterase, similar to MTCY493.28, MTCY08D5.15, [NAME] similar esp. in C-terminus to M. tuberculosis hypothetical protein Q50681 (431 aa) (50.1% identity in 411 aa overlap), and also similar in central region to AAAD_HUMAN P22760 arylacetamide deacetylase (398 aa), [NAME] scores; opt:210 z-score: 248.8 E(): 7.6e-07, 29.3% identity in 191 aaoverlap
Rv1452c | Rv1452c | PE_PGRS28 | 0.6880385 | 0.7127095 | 0.7869277 | 0.8362357 | 0.82521415 | 0.8190479 | 0.85619843 | 0.9331737 | Rv1452c, (MTCY493.02), len: 741. Member of the PGRS(PE) family of glycine-rich proteins, similar to eg. Y03A_MYCTU Q10637 hypothetical glycine-rich 49.6 kd protein (603aa), [NAME] scores; opt: 2090 z-score: 1407.8 E(): 0, 56.3%identity in 641aa overlap
Rv1488 | Rv1488 |  | 0.8950681 | 0.89390796 | 0.949679 | 1.0032827 | 1.0164568 | 0.98700494 | 1.0279217 | 1.06153 | Rv1488, (MTCY277.09), len: 381. Similar to YBBK_ECOLI (BAND 7/MEC-2 FAMILY) SPTREMBL:P77367 (305 aa). [NAME] scores, opt: 716 E(): 0; 37.1% identity in 307 aa overlap
Rv1582c | Rv1582c |  | 0.9137915 | 0.9497764 | 0.9977199 | 1.1061739 | 1.0040543 | 1.079777 | 1.2331325 | 1.2308792 | Rv1582c, ([NAME]), len: 471. Function: unknownbut N-terminus is similar to C-terminus of [NAME] and C-terminus to whole of ORF10 of Streptomyces phage phi-C31. FASTAresults, Q38031 ORF 10. (202 aa) opt: 353 z-score: 425.7 E(): 1e-16;31.1% identity in 190 aa overlap. Q38030 ORF 9 opt: 331; E(): 6.5e-15; 28.5% identity in 235 aa overlap. Alsoslightlysimilar to [NAME], E(): 0.0055; 36.0% identityin 75aa overlap; belongs to #[NAME] proteins
Rv1584c | Rv1584c |  | 1.0690848 | 1.0396662 | 1.1251599 | 1.1465759 | 1.2014563 | 1.235735 | 1.2020316 | 1.398082 | Rv1584c, (MTCY336.20), len: 73. Function: Unknown.TBparse score is 0.883
impA | Rv1604 |  | 0.7441612 | 0.71789455 | 0.79748607 | 0.8224 | 0.79456997 | 0.83013606 | 0.89528215 | 0.96155405 | Rv1604, (MTV046.02), impA, len: 270. Probable inositol monophosphatase, similar to e.g. gp|AF0059|AF005905_2 Mycobacterium smegmatis phosphori (276 aa), FASTA scores: opt: 1241 z-score: 1462.4 E(): 0; 70.5% identity in 261 aa overlap
chaA | Rv1607 |  | 0.79245645 | 0.7572575 | 0.91106814 | 0.9766217 | 0.95893985 | 0.9508669 | 1.0435114 | 1.1885822 | Rv1607, (MTV046.05), [NAME], len: 360. Probable ionictransporter, putative calcium/proton antiporter, similar tomany, e.g. sp|P31801|CHAA_ECOLI CALCIUM/PROTON ANTIPORTER. (366 aa), opt: 736 z-score: 894.7 E(): 0; 35.9% identityin351 aa overlap. TBparse score is 0.888
argJ | Rv1653 |  | 0.91440225 | 1.085213 | 1.1118349 | 1.1547375 | 1.1865959 | 1.1790334 | 1.3754936 | 1.4874773 | Rv1653, (MTCY06H11.18), argJ, len: 404. Glutamate n-acetyltransferase, similar to eg ARGJ_BACSU P36843, (406 aa), [NAME] scores, opt: 727, E(): 0, (36.3% identity in 410 aa overlap)
argD | Rv1655 |  | 0.92362463 | 1.0874411 | 1.1893591 | 1.235057 | 1.3224382 | 1.2753786 | 1.453316 | 1.6161569 | Rv1655, (MTCY06H11.20), argD, len: 400. [NAME] aminotransferase, similar to eg ARGD_ECOLI P18335 (406aa), [NAME] scores, opt: 958, E(): 0, (38.6% identity in 404aa overlap), contains PS00600 Aminotransferases class-IIIpyridoxal-phosphate attachment site
argR | Rv1657 |  | 0.76955247 | 0.83713704 | 0.80287963 | 0.92590904 | 0.9374596 | 0.88878506 | 1.003165 | 1.0981958 | Rv1657, (MTCY06H11.22), [NAME], len: 170. Argine repressor, ahrC or argR, Similar to eg [NAME] P17893 arginine hydroximate resistance protein (149 aa), [NAME] scores, opt: 283, E(): 1.8e-11, (34.5% identity in 142 aa overlap) and arginine repressor ARGR_ECOLI P15282 arginine repressor (156 aa), fastascores, opt: 194, E(): 6.4e-06 (30.8% identity in 146 aa overlap)
Rv1678 | Rv1678 |  | 0.8508044 | 0.85538363 | 0.94549775 | 1.0217761 | 1.0160724 | 0.9905148 | 1.1009252 | 1.1592802 | Rv1678, (MTV047.13), len: 300. Unknown, probable integral membrane protein.
Rv1680 | Rv1680 |  | 0.9119829 | 0.9779844 | 1.0356604 | 1.020993 | 1.0196445 | 1.0733918 | 1.1151376 | 1.1239334 | Rv1680, (MTCI125.02), len: 274. Unknown.
cycA | Rv1704c |  | 0.8579547 | 0.7714658 | 0.85660416 | 0.92047656 | 0.9541021 | 0.95724344 | 1.0944251 | 1.2298521 | Rv1704c, (MTCI125.26c), cycA, len: 556. D-serine/d-alanine/glycine transporter, highly similar to CYCA_ECOLI P39312 d-serine/d-alanine/glycine transporter (470 aa), [NAME] scores; opt: 1906 z-score: 2124.4 E(): 0, 59.3% identityin 459 aa overlap, and to other amino-acid pemeases. Contains PS00218 Amino acid permeases signature. Also similar toother M.tuberculosis amino-acid permeases eg. MTCY13E10.06c (38.1%identity in 465 aa overlap)
Rv1714 | Rv1714 |  | 0.7314607 | 0.7418723 | 0.88380706 | 1.0274814 | 0.97960126 | 1.1328257 | 1.1996297 | 1.3861583 | Rv1714, (MTV048.01), len: 270. Probable oxidoreductase / gluconate 3-dehydrogenase similar to many e.g. gp|AE0010|AE001021_4 Archaeoglobus fulgidus section 79 (281 aa),opt: 578 z-score: 695.0 E(): 3.3e-31, 38.9% identity in 265aa overlap. Also similar to MTCY9F9_23 M. tuberculosis cosmid (256 aa), 36.6% identity in 254 aa overlap and MTY13E12_38 M. tuberculosis cosmid (314 aa), opt: 405 z-score: 489.0 E(): 9.9e-20; 32.9% identity in 255 aa overlap
fadB3 | Rv1715 |  | 0.8558858 | 0.97248816 | 1.0306973 | 1.253696 | 1.1748286 | 1.2864311 | 1.3424187 | 1.6441525 | Rv1715, (MTV048.02), len: 304; fadB3, Probable 3-hydroxybutyryl-CoA dehydrogenase, similar to many, e.g.gp|U29084|BSU29084_2 Bacillus subtilis (mmgA), (mmgB), (287 aa), FASTA scores:opt:488 z-score: 575.4 E(): 1.5e-24. 38.7% identity in 279 aaoverlap
Rv1718 | Rv1718 |  | 0.78596383 | 0.8269032 | 1.014392 | 1.3180915 | 1.144807 | 1.3526483 | 1.6580513 | 1.9859791 | Rv1718, (MTCY04C12.03), len: 272. Similar to hypothetical protein from Archeoglobus, TR:O29058 (EMBL:AE001021)AF1210 (313 aa), fatsta scores; opt: 301 z-score: 539.0 E(): 8e-23, 31.6% identity in 301 aa overlap
[NAME] | [NAME] |  | 0.76920366 | 0.7495842 | 0.859261 | 0.886151 | 0.9246856 | 0.9228399 | 1.1283131 | 1.1793607 | [NAME], (MTCY04C12.04), len: 259, Similar to transcriptional regulators eg YIAJ_ECOLI P37671 hypothetical transcriptional regulator (282 aa), [NAME] scores, opt: 353, E(): 3.2e-15, (31.1% identity in 235 aa overlap). Helix-turnhelix motif from aa 34-55(+6.94 SD)
Rv1824 | Rv1824 |  | 0.7963087 | 0.75793177 | 0.8914551 | 0.9766473 | 1.0563185 | 0.95239496 | 1.1895738 | 1.1667253 | Rv1824, (MTCY1A11.19c), len:121, similar to SBP_BACSU P28265 sbp protein (121 aa), FASTA scores, opt: 261, z-score: 348.2, E(): 1.9e-12, (38.9% identity in 113 aa overlap)
gcvB | Rv1832 |  | 0.77693707 | 0.761545 | 0.8073336 | 0.8638182 | 0.8590586 | 0.9027196 | 1.029672 | 1.155957 | Rv1832, (MTCY1A11.11c), gcvB, glycine decarboxylase, len: 941, highly similar to eg GCSP_ECOLI P33195 glycine dehydrogenase (decarboxylating) (957 aa), FASTA scores, opt: 2194, z-score: 2375.9, E(): 0, (55.4% identity in 961 aa overlap)
ureC | Rv1850 |  | 0.8265145 | 0.8052921 | 0.89599764 | 1.0010192 | 0.92878515 | 0.94988877 | 1.0663573 | 1.1181382 | Rv1850, ([NAME]), len: 577. Function: ureC, urease alpha subunit; has PS00145 Urease active site motif. FASTA best: URE1_MYCTU P50042, (577 aa), opt: 3794, E(): 0, (98.3% identity in 577 aa overlap. TBPARSE score is 0.898)
modD | Rv1860 | apa;mpt32 | 0.68016434 | 0.7007896 | 0.7638968 | 0.84324455 | 0.81792456 | 0.8041568 | 1.0023386 | 0.9562982 | Rv1860, (MTCY359.0013), modD, len: 325. Function: Precursor of Apa, Ala-Pro rich 45/47 [NAME] secreted protein. Identical to G1008136 45/47 gene precursor (325 aa), also referred to as modD in submission X99258, possibly involved in molybdate uptake. Very similar to P46842|N43L_MYCLE ANTIGEN 43L PRECURSOR. - MYCOBAC (287 aa) opt: 1166; E(): 0; 66.4% identity in 298 aa overlap. TBPARSE score is 0.924
lldD2 | Rv1872c |  | 0.9521873 | 0.9514398 | 1.0857228 | 1.1050022 | 1.0964483 | 1.1228257 | 1.2781081 | 1.2587026 | Rv1872c, (MTCY180.46, MTCY359.01), lldD2, probable oxidoreductase, len: 414. Similar to lactate dehydrogenase and other oxidases. Start uncertain. FASTA results: Q51135 LACTATE DEHYDROGENASE (390 aa) opt: 309; E(): 4.1e-15; 42.5% identity in 113 aa overlap. TBparse score is 0.893. Also shows weak similarity to M. tuberculosis protein MTCY210.11(34.0% identity in 103 aa overlap).MTCY359.01, lldD. [NAME]: 283 (partial),contains PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. FASTA best: LLDD_ECOLI P33232 l-lactate dehydrogenase (cytochrome) (396 aa), opt: 674, E(): 1.1e-37, (40.5% identity in 279 aa overlap). Also similar to Rv0694, (396 aa, 35.8% identity in 377 aa overlap), TBPARSE score is 0.905
[NAME] | Rv2064 |  | 0.6878519 | 0.6656847 | 0.751902 | 0.7282856 | 0.7506565 | 0.7667619 | 0.88379925 | 0.9047803 | Rv2064, ([NAME]), len: 363, Some similarity to COBG_PSEDE P21637 cobg protein. pseudomona (459 aa) FASTA scores, opt: 240, z-score: 271.9, E(): 1.3e-08, (27.5% identity in 407 aa overlap); contains PS01156 TonB-dependent receptor proteins signature 2
murD | Rv2155c |  | 0.7388819 | 0.6963382 | 0.81330895 | 0.8694118 | 0.8682563 | 0.8624842 | 0.9663384 | 0.9765706 | Rv2155c, (MTCY270.13), len: 486. Function: probableUDP-N-acetylmuramoylalanine-D-glutamate ligase (EC 6.3.2.9). FASTA best: MURD_BACSU Q03522 (451 aa) opt: 534 z-score:579.8 E(): 2.7e-25; (28.8% identity in 483 aa overlap); containsPS01011 Folylpolyglutamate synthase signature 1
Rv2164c | Rv2164c |  | 0.70986736 | 0.79250425 | 0.8325235 | 0.9011656 | 0.89944786 | 0.9078606 | 1.0681876 | 1.0913527 | Rv2164c, ([NAME]), len: 384. Function: unknown proline rich protein
[NAME] | Rv2192c |  | 0.69500655 | 0.68467396 | 0.70852953 | 0.73832726 | 0.75621855 | 0.7385759 | 0.7853658 | 0.77743393 | Rv2192c, ([NAME]), len: 370. Probable anthranilate phosphoribosyltransferase, TRPD, similar to eg SW:TRPD_LACCA P17170, (43.2% identity in 308 aa overlap), initiatiation codon uncertain, gtg at 4086 favoured by homology butthis has no clear ribosome binding site
accD6 | Rv2247 |  | 0.890146 | 0.8830342 | 1.0084031 | 0.9852454 | 0.97081983 | 1.0464472 | 1.1866589 | 1.1791203 | Rv2247, (MTCY427.28), len: 520, accD6 - Acetyl/Propionyl CoA Carboxylase beta subunit, highly similar to SW:PCCB_RHOSO Q06101 propionyl-CoA carboxylase beta chain (75.1%identity in 437 aa overlap). Similar to many other M. tuberculosis Acetyl/Propionyl CoA Carboxylases
Rv2248 | Rv2248 |  | 0.9307762 | 0.910399 | 1.0977594 | 1.1389093 | 1.15612 | 1.2067094 | 1.4390233 | 1.4464743 | Rv2248, (MTCY427.29), len: 271. Very similar to hypothetical M. tuberculosis proteins [NAME] and MTCY06G11.02c. FASTA score: MTCY06G11.02c MTCY6G11 NID: g1877284 - (289 aa) opt: 366 E(): 5.3e-18; (32.1% identity in 249 aa overlap). Some similarity to M. avium protein AF002133|AF0021339 AF002133 NID: g2183254 - Mycoba (346 aa)opt: 308 E():5.2e-14; (28.3% identity in 254 aa overlap)
Rv2434c | Rv2434c |  | 0.8246233 | 0.83697563 | 0.8818518 | 0.99387497 | 1.0239785 | 0.9941844 | 1.0409049 | 1.1036249 | Rv2434c, (MTCY428.12), len: 481. Probable membrane protein with some similarity to YGGB_ECOLI P11666 hypothetical 30.9 kd protein in sbm- (286 aa), [NAME] scores, opt: 187, E(): 2.1e-05, (22.4% identity in 241 aa overlap)
proB | Rv2439c |  | 0.6661353 | 0.6478797 | 0.7421539 | 0.7836952 | 0.75138485 | 0.7503171 | 0.8876608 | 0.99212784 | Rv2439c, (MTCY428.07), len: 376. Probable proB, glutamate 5-kinase, similar to eg PROB_CORGL P46546 glutamate 5-kinase (369 aa), [NAME] scores, opt: 1241, E(): 0, (54.3% identity in 368 aa overlap); contains PS00902 Glutamate 5-kinase signature
Rv2468c | Rv2468c |  | 0.6860795 | 0.6327113 | 0.69884014 | 0.7298442 | 0.7125635 | 0.7449975 | 0.81521416 | 0.8979985 | Rv2468c, (MTV008.24c), len: 167 aa. Unknown
pdhB | Rv2496c |  | 0.8047157 | 0.77805686 | 0.8264463 | 0.8518239 | 0.84955335 | 0.85802275 | 0.9173611 | 0.9933086 | Rv2496c, (MTCY07A7.02c), len: 348 aa. pdhB, similar to eg ODPB_BACST P21874 pyruvate dehydrogenase e1 component, BETA SUBUNIT (EC 1.2.4.1) (324 aa), [NAME] scores, opt: 951 z-score: 1108.3 E(): 0, (47.7% identity in 321 aa overlap)
Rv2508c | Rv2508c |  | 0.7714689 | 0.8034197 | 0.8375105 | 0.89162666 | 0.887469 | 0.85599995 | 0.97623706 | 1.0041349 | Rv2508c, (MTCY07A7.14c), len: 445 aa. Unknown membrane protein, equivalent to Mycobacterium leprae [NAME] (464 aa) [NAME] scores: opt: 2205 z-score: 2631.5 E(): 0; 75.7% identity in 441 aa overlap; also similar to YXIO_BACSU P42306 hypothetical 47.3 kd protein in wapa- (428 aa) opt: 220 z-score: 257.8 E(): 2.4e-07 (19.7% identity in 412 aa overlap)
hisS | [NAME] |  | 0.79798967 | 0.8124235 | 0.79977036 | 0.83134186 | 0.85736257 | 0.8308565 | 0.9124853 | 0.9382101 | [NAME], (MTCY227.21), len: 423. hisS, histidyl-trna synthetase, highly similar to SYH_MYCLE P46696 histidyl-trna synthetase (427 aa), FASTA scores, opt: 2375, z-score: 2558.1, E(): 0, 84.9% identity in 424 aa overlap; contains PS00017 [NAME]/GTP-binding site motif A
ruvB | Rv2592c |  | 0.78126174 | 0.7216614 | 0.80083597 | 0.8112617 | 0.8701176 | 0.8666704 | 0.99904335 | 1.0385164 | Rv2592c, (MTCY227.09), len: 344 aa. Holliday junction binding protein ruvB, RUVB_MYCLE P40833 probable holliday junction dna helicase (369 aa) FASTA scores, opt: 1929, z-score: 2176.5 E(): 0, (94.4% identity in 321 aa overlap); contains PS00017 [NAME]/GTP-binding site motif A
Rv2609c | Rv2609c |  | 0.79287636 | 0.8471712 | 0.9232022 | 0.92554265 | 0.87359565 | 0.9623074 | 1.0211158 | 1.0649515 | Rv2609c, (MTCY01A10.24), len: 351 aa. Unknown; equivalent to Z96801|MLCL581_7 Mycobacterium leprae cosmid L581; (349 aa) [NAME] score: opt: 1675 z-score: 2006.1 E(): 0; 77.8% identity in 334 aa overlap. Contains PS00893mutTdomain signature
pgsA | Rv2612c | pgsA1 | 0.8479788 | 0.76399934 | 0.88585204 | 0.9467467 | 1.1108527 | 1.0003008 | 1.1431968 | 1.240121 | Rv2612c, (MTCY01A10.21), len: 217 aa. Probable pgsAsimilarity to CDP-diacylglycerol--glycerol-3-phosphate phosphatidyltransferases, equivalent to Z96801|MLCL581_10 Mycobacterium leprae cosmid L581; (239 aa) [NAME] scores: opt: 1141 z-score: 1451.6 E(): 0; 79.3% identity in 213 aaoverlap; contains PS00379 CDP-alcohol phosphatidyltransferases signature, similar to eg PIS_YEAST P06197 cdp-diacylglycerol--inositol 3-phosphatidyltransferase (220 aa) opt: 124z-score: 162.5 E(): 0.048, (32.9% identity in 85 aa overlap)
Rv2644c | Rv2644c |  | 0.99009526 | 1.0703394 | 1.1686267 | 1.2688088 | 1.2059801 | 1.3199666 | 1.3076133 | 1.4083588 | Rv2644c, (MTCY441.14c), len: 105. Unknown
dut | Rv2697c |  | 1.0800785 | 1.1274979 | 1.0729349 | 1.1254843 | 1.1551626 | 1.256539 | 1.3505915 | 1.305946 | Rv2697c, (MTCY05A6.18c), len: 154. dut, deoxyuridine 5'-triphosphate nucleotidohydrolase. Highly similar to M.leprae protein and also to other deoxyuridine 5'-triphosphate nucleotidohydrolases (e.g. P43058). FASTA best: G699195COSMID B1764 opt: 932; E(): 0; 90.9% identity in 154 aa overlap. TBparse score is 0.897
Rv2713 | Rv2713 | sthA | 1.1736463 | 1.3018162 | 1.3181267 | 1.5435417 | 1.4932214 | 1.5763443 | 1.6553342 | 1.6438472 | Rv2713, (MTCY05A6.34), len: 468. Function: unknown dehydrogenase showing strong similarity to various dehydrogenases (e.g. lipoamide dehydrogenase). Has ATP/GTP-binding site motif A (P-loop; PS00017). FASTA best: UDHA_ECOLI P27306 unknown dehydrogenase a (ec 1.-.-.-). (444 aa)opt: 1180;E(): 0; 42.4% identity in 441 aa overlap. Some similarity to MTCY359.04, 3.1e-08; MTCY210.05, 3.4e-08. TBparse score is 0.884
Rv2732c | Rv2732c |  | 0.7810156 | 0.72562444 | 0.789809 | 0.80824566 | 0.8423441 | 0.85817266 | 0.96962917 | 0.9946344 | Rv2732c, (MTCY174.12c), len: 204 aa. Similar to M. leprae hypothetical protein TR:Q49834 B2235_C1_155 (209 aa), [NAME] scores; opt: 932 z-score: 916.4 E(): 0, 70.6% identity in 201 aa overlap. Contains PS00343 Gram-positive coccisurface proteins 'anchoring' hexapeptide
Rv2772c | Rv2772c |  | 0.7961102 | 0.75805163 | 0.81262195 | 0.8950793 | 0.8526295 | 0.8642142 | 0.9516091 | 0.9959592 | Rv2772c, (MTV002.37c), len: 157 aa. Unknown; similar to M. bovis hypothetical protein YDAB_MYCBO P46830 hypothetical 19.3 kd protein in dapb 3' region (177 aa), [NAME] scores; opt: 337 z-score: 536.6 E(): 9.8e-23, 40.7% identity in 135 aa overlap
ugpC | Rv2832c |  | 0.7898499 | 0.8849041 | 0.85243607 | 0.8790887 | 0.8886704 | 0.91330254 | 1.0045487 | 1.0533917 | Rv2832c, ([NAME]), len: 360 aa. ugpC homologuesimilar to UGPC_ECOLI P10907 sn-glycerol-3-phosphate transport atp-binding protein (356 aa), [NAME] scores, opt: 953, E(): 0, (44.8% identity in 366 aa overlap) also MTCY9C4.04c,(37.1% identity in 213 aa overlap); and S. reticuli sp|P96483|P96483 GENE ENCODING MSIK PROTEIN AND ORF1. (377 aa) opt: 1277 z-score: 1450.2 E(): 0; 58.0% identity in 379 aa overlap; contains PS00017 [NAME]/GTP-binding site motifA,PS00211 ABC transporters family signature
Rv2837c | Rv2837c |  | 0.7481566 | 0.7980814 | 0.8199981 | 1.0035328 | 1.0197164 | 1.0077368 | 1.1049093 | 1.1394607 | Rv2837c, (MTCY16B7.05), len: 336. Unknown but slight similarity to [NAME] burgdorferi (section 4 (330 aa) [NAME] score, opt: 302 z-score: 375.1 E(): 2.3e-13; 26.3% identity in 293 aa overlap; and to G1046081 hypothetical 37.2 kDa protein (324 aa), [NAME] scores, opt: 256, E(): 4e-10, (22.6% identity in 292 aa overlap)
efpA | Rv2846c |  | 0.9033728 | 1.047889 | 1.0896046 | 1.1874971 | 1.1332971 | 1.1746043 | 1.3932703 | 1.3586445 | Rv2846c, (MTCY24A1.11), len: 530 aa. efpA, putativeefflux protein, almost identical to EMBL; L39922; G1161051EFFLUX PROTEIN
Rv2869c | Rv2869c |  | 0.7619286 | 0.82768357 | 0.89069104 | 0.9522342 | 0.9539967 | 0.94297117 | 1.1010715 | 1.1136705 | Rv2869c, (MTV003.15c), len: 404 aa. Probable integral membrane protein; weakly similar to hypothetical proteins from many organisms eg. YAEL_ECOLI P37764 hypothetical 49.1 kd protein in cdsA-hlpA intergenic region (450 aa), [NAME] scores; opt: 297 z-score: 387.8 E(): 1.9e-14, 23.8% identity in 442 aa overlap
Rv2897c | Rv2897c |  | 1.0901383 | 1.2198076 | 1.2003592 | 1.2575773 | 1.3522344 | 1.2598013 | 1.3863491 | 1.4521177 | Rv2897c, (MTCY274.28c), yifB, len: 503, similar to YIFB_ECOLI P22787 hypothetical 56.2 kd protein in pssr-ilvlintergenic region (516 aa), FASTA scores, opt: 1080, z-score: 1075.3, E(): 0, (38.9% identity in 501 aa overlap), alsoto [NAME] P45049 hypothetical protein [NAME]. (509 aa)FASTA scores, opt: 1049, z-score: 1044.7, E(): 0, (38.1% identity in 506 aa overlap); contains PS00017 [NAME]/GTP-binding site motif A
Rv2994 | Rv2994 |  | 0.8296519 | 0.8801679 | 1.0083705 | 1.0403477 | 1.0151181 | 0.997462 | 1.2562982 | 1.3055687 | Rv2994, (MTV012.08), len: 445. Unknown membrane protein similar to fluoroquinolone efflux proteins of Staphylococci and in part to probable pseudogene product, hypothetical protein MLCB637.27c, of Mycobacterium leprae. FASTA scores: sp|P21191|NORA_STAAU QUINOLONE RESISTANCE NORA PROTEIN(388 aa) opt: 230 z-score: 258.5 E(): 6.5e-07; (22.0% identity in 373 aa overlap) and gp|Z99263|MLCB637_27 Mycobacterium leprae (134 aa) opt: 483 z-score: 540.7 E(): 1.2e-22;(60.9% identity in 138 aa overlap). First start taken, similarity to NorA suggests alternative start at 7319 but thennopositively charged aa before first transmembrane segment. TBparse score is 0.925
[NAME] | [NAME] |  | 0.8222612 | 0.83333766 | 0.8911837 | 0.9209213 | 0.8902405 | 0.91283613 | 1.016792 | 0.9992585 | Rv3030, (MTV012.45), len: 274. Equivalent to Mycobacterium leprae hypothetical protein MLCB637.02c, N-terminushas similarity to hypothetical proteins from a number of organisms and to TR:Q54303 EMBL:X86780) methyltransferase from Streptomyces hygroscopicus (317 aa). FASTA score: Z99263|MLCB637_2 (280 aa) opt: 1388 z-score: 1710.5 E(): 0; (78.2%identity in 280 aa overlap). TBparse score is 0.902
atsF | Rv3077 |  | 0.85135156 | 0.84652346 | 0.8642483 | 0.9225893 | 0.951641 | 0.97446275 | 1.0794592 | 1.1021527 | Rv3077, (MTCY22D7.04c), len: 603. atsF, some similarity to variety of aryl- and steryl sulfatases. FASTA best: G1177864 PHOSPHONATE MONOESTER HYDROLASE (514 aa) opt: 239 z-score: 265.5 E(): 8.4e-08. (24.0% identity in 413 aa overlap). TBparse score is 1.002
Rv3081 | Rv3081 |  | 0.915291 | 0.9030009 | 0.9657764 | 1.1240278 | 1.1531365 | 1.0302091 | 1.313455 | 1.3545599 | Rv3081, (MTV013.02), len: 412. Unknown. Contains PS00850 Glycine radical signature and possible helix-turn-helix motif at positions 53-74. TBparse score is 0.940
fadE23 | Rv3140 |  | 0.7678131 | 0.83299863 | 0.9554482 | 1.0209249 | 1.0215446 | 1.0198402 | 1.1020622 | 1.1380872 | Rv3140, (MTCY03A2.18c), len: 401.fadE23, PUTATIVE ACYL-COA DEHYDROGENASE, similar to ACDS_HUMAN P16219 acyl-CoA dehydrogenase, short-chain (412 aa), FASTA scores: opt:575, E(): 6.4e-30, (31.2% identity in 394 aa overlap). EQUIVALENT to MLCB1779_21 Mycobacterium leprae (400 aa, 89.5%identity in 401 aa overlap) TBparse score is 0.890
nuoB | Rv3146 |  | 1.1338333 | 1.117599 | 1.1051335 | 1.1180675 | 1.1934762 | 1.214126 | 1.366397 | 1.3147367 | Rv3146, (MTCY03A2.12c), len: 184, nuoB, NADH dehydrogenase subunit. FASTA best: sp|Q56218|NQO6_THETH NADH dehydrogenase I,subunit NQO6 (181 aa), opt: 720, E(): 0, (64.5%identity in 152 aa overlap), TBparse score is 0.912
[NAME] | Rv3154 |  | 0.7739263 | 0.75632006 | 0.73683196 | 0.8024432 | 0.8294915 | 0.8500151 | 0.85878915 | 0.9043732 | Rv3154, (MTCY03A2.04c), len: 262, NuoJ, NADH dehydrogenase transmembrane subunit. FASTA best: NU6C_PLEBO [NAME] nadh-plastoquinone oxidoreductase cha (199 aa) initn: 231 init1: 160 opt: 287 z-score: 336.8 E(): 8.9e-12; 34.4% identity in 195 aa overlap. TBparse score is 0.890
Rv3284 | Rv3284 |  | 0.8432468 | 0.9527214 | 0.99057996 | 1.0766016 | 1.067339 | 1.0381379 | 1.2307122 | 1.206658 | Rv3284, (MTCY71.24, unknown), len: 143 aa, similar to E. coli [NAME] (147 aa), [NAME] scores, opt: 187, E(): 2.3e-06, (29.5% identity in 139 aa overlap)
Rv3384c | Rv3384c |  | 0.9341287 | 0.8767863 | 1.0176595 | 1.0676341 | 1.0938115 | 1.0989368 | 1.1553625 | 1.2729945 | Rv3384c, (MTV004.42c), len: 130 aa; unknown, similar to other M. tuberculosis hypothetical proteins TR:P95252 (EMBL:Z84498) MTCY09F9.02 (135 aa) (43.1% identity in 130 aa overlap) and Y09L_MYCTU Q50717 MTCY78.20c (136 aa) (35.1%identity in 131 aa overlap)
rimI | Rv3420c |  | 0.68560225 | 0.65114707 | 0.71265346 | 0.76321334 | 0.78352404 | 0.7837908 | 0.84325784 | 0.8978967 | Rv3420c, (MTCY78.09), len: 158 rimI, acetyltransferase, highly similar to U00020_6 (G467109) M. leprae cosmid B229 (359 aa) [NAME] scores, opt: 772, z-score: 888.2, E(): 0, (72.1% identity in 154 aa overlap) and similar to RIMI_ECOLI P09453 ribosomal-protein-alanine acetyltransferase (161 aa) [NAME] scores, opt: 204, z-score: 245.8, E(): 9.5e-07,(34.0% identity in 153 aa overlap)
rpoA | Rv3457c |  | 0.9120814 | 0.91450745 | 0.910751 | 1.0376302 | 1.0910093 | 1.1027099 | 1.3074394 | 1.2628644 | Rv3457c, (MTCY13E12.10c), len: 347. rpoA. Function:probable alpha subunit of RNA polymerase. Contains ATP/GTP-binding site motif A (P-loop; PS00017). FASTA results: RPOA_STRCO P72404 dna-directed rna polymerase alpha chain (339aa) opt: 1644; E(): 0; (75.0% identity in 348 aa overlap)
[NAME] | [NAME] | mce4D | 0.8467102 | 0.77891624 | 0.8384488 | 0.9015255 | 0.8776708 | 0.9196304 | 1.0353878 | 1.0119716 | [NAME], (MTV023.03c), len: 451. Unknown but similar to Mycobacterium tuberculosis proteins MTCI28.12 (530 aa), MTCY19H5.30c (508 aa) (MTV051.07). Hydrophobic region at N-terminus. FASTA scores: [NAME] (530 aa) opt:838 z-score: 711.0 E(): 4.3e-32; 35.1% identity in 473 aaoverlap; and Z97182|MTCY19H5_30 (508 aa) opt: 821 z-score:697.0 E(): 2.6e-31; 35.1% identity in 453 aa overlap.TBparse score is 0.891
ilvX | Rv3509c |  | 0.8381762 | 0.9629428 | 0.9812855 | 1.0736885 | 1.0381382 | 1.0637196 | 1.3293916 | 1.2193515 | Rv3509c, (MTV023.16), len: 515. [NAME]. Probable acetohydroxyacid synthase equivalent to Mycobacterium leprae protein described as Acetolactate synthase I, valine sensitive, large subunit U00020_36 (515 aa). Other M. tuberculosis proteins e.g. MTV012.17c, show better similarity to Acetolactate synthase I. Also weakly similar to other acetohydroxyacid synthases. FASTA scores: U00020|U00020_36 (515 aa)opt: 2762 z-score: 2961.4 E(): 0; 82.9% identity in 515aaoverlap. TBparse score is 0.902
cysS | Rv3580c | cysS1 | 1.0219685 | 0.9625551 | 0.9637885 | 1.1330034 | 1.1046293 | 1.2209429 | 1.2311858 | 1.4173977 | Rv3580c, (MTCY06G11.27c), cysS, len: 469. Cysteinyl-trna synthetase, similar to eg SYC_ECOLI P21888 cysteinyl-trna synthetase (461 aa), [NAME] scores, opt: 1189, E(): 0,(42.8% identity in 463 aa overlap)
Rv3588c | Rv3588c |  | 0.8453782 | 0.98506397 | 0.93558943 | 1.0464095 | 0.96688443 | 1.2030951 | 1.2489991 | 1.2254226 | Rv3588c, (MTV024.06c), len: 207. PUTATIVE CARBONICANHYDRASE, similar to many, e.g. gp|D64001|SYCCPNC_32 Synechocystis sp. [NAME] complet (263 aa); opt: 401 z-score: 517.0 E(): 2.8e-21; 37.6% identity in 194 aa overlap. Belongs to theplant and prokaryotic carbonic anhydrases family.Contains PS00704 and PS00705 Prokaryotic-type carbonic anhydrasessignature 1 and 2. TBparse score is 0.899
Rv3605c | Rv3605c |  | 0.73494494 | 0.8091266 | 0.7718806 | 0.8974106 | 0.878928 | 0.90059865 | 0.9437726 | 0.965787 | Rv3605c, (MTCY07H7B.17), len: 158. Unknown, contains possible N-terminal signal sequence
folE | Rv3609c |  | 1.0361598 | 1.1967267 | 1.1454104 | 1.1627156 | 1.266282 | 1.2675239 | 1.379044 | 1.3681681 | Rv3609c, (MTCY07H7B.13), [NAME], len: 202. GTP cyclohydrolase I, similar to e.g. [NAME] P19465 gtp cyclohydrolase i (ec 3.5.4.16) FIRST STEP INTHE BIOSYNTHESIS OF TETRAHYDROFOLATE (190 aa), [NAME] scores, opt: 750, E(): 0, (58.9% identity in 190 aa overlap); contains PS00860 GTP cyclohydrolase I signature 2
Rv3691 | Rv3691 |  | 0.7021901 | 0.68993163 | 0.8050219 | 0.8145326 | 0.8199142 | 0.84579676 | 0.9678674 | 1.0020978 | Rv3691, ([NAME]), len: 333. Unknown. TBparse score is 0.931
[NAME] | Rv3692 |  | 0.75075346 | 0.6651761 | 0.7297921 | 0.7226008 | 0.79661435 | 0.8202405 | 0.9332116 | 0.9722071 | Rv3692, (MTV025.040), len: 358. Probable regulatory protein; similar to many, e.g. B. subtilis YEAC (320 aa);MTV014_8 M. tuberculosis putative regulatory protein; BBGIDBMOX_2B.burgdorferi gidB moxR genes (329 aa); AE001108_10Archaeoglobus fulgidus MoxR (324 aa),putative methanol dehydrogenaseregulatory protein. Also similar to MTV007_26 M. tuberculosis, AF002133_6 Mycobacterium avium. FASTA scores:gp|Z99107|BSUB0004_80 Bacillus subtilis complete genom (320aa);opt: 949 z-score: 914.8 E(): 0; 48.8% identity in 299aaoverlap.TBparse score is 0.912
Rv3722c | Rv3722c |  | 0.9387016 | 0.9094151 | 0.938687 | 1.0114797 | 1.0060569 | 0.97947586 | 1.0788809 | 1.0949833 | Rv3722c, (MTV025.070c), len: 408. Unknown. TBparsescore is 0.900
Rv3726 | Rv3726 |  | 0.83584285 | 0.8722434 | 0.90774524 | 0.9416356 | 0.90685874 | 0.93253785 | 1.0308809 | 1.0182292 | Rv3726, (MTV025.074), len: 397. Putative alcohol dehydrogenase, similar to zinc-type alcohol dehydrogenase, e.g. sp|P39400|YJJN_ECOLI HYPOTHETICAL ZINC-TYPE ALCOHOL DE (345 aa)FASTA scores: opt: 321 z-score: 387.4 E(): 4.6e-14. 30.5% identity in 256 aa overlap. ALSO similar to L-iditol 2-dehydrogenase/BSUB0004_71, Bacillus subtilis, 29.6%identityin 395aa overlap. TBparse score is 0.922
Rv3783 | Rv3783 | rfbD | 0.85764855 | 0.8387312 | 0.94648165 | 0.96741825 | 1.0230486 | 0.9907356 | 1.115269 | 1.1277261 | Rv3783, (MTCY13D12.17), len: 280. Probable transport system permease, similar to e.g. [NAME] export system permease prot (259 aa), [NAME] scores; opt: 566 z-score: 934.5 E(): 0, 28.0% identity in 264 aa overlap
embC | Rv3793 |  | 0.82166064 | 0.82678527 | 0.8567882 | 0.9319184 | 0.89144313 | 0.9470388 | 1.0272169 | 1.0509694 | Rv3793, (MTCY13D12.27), embC, len: 1094. Probable arabinosyltransferase, highly similar to fragment sequence of MYCOBACTERIUM [NAME], G1197631 embC (257 aa), [NAME] scores, opt: 1431, E(): 0, (78.3% identity in 258 aa overlap), similar to G1197633 embB, (1066 aa) opt: 2742, E(): 0, (44.8% identity in 1096 aa overlap); contains PS00044 Bacterial regulatory proteins, [NAME] family signature; PS00017 [NAME]/GTP-binding site motif A
pks13 | Rv3800c |  | 0.7148625 | 0.7155776 | 0.73128116 | 0.8040536 | 0.82385135 | 0.8798314 | 0.98929006 | 1.0960742 | Rv3800c, (MTV026.05c), len: 1733. Probable polyketide synthase, similar to many. e.g. gp|M63676|SERERYAA_1 S.erythraea first ORF of eryA gene, involved in complex polyketide formation in erythromycin biosynthesis. FASTA scores: opt: 1329 z-score: 1411.0 E(): 0, 33.6% identity in 1232 aa overlap or to AF040570_9 Amycolatopsis mediterranei rifamycin biosynthetic gene cluster (3413 aa), 34.3% identity in 1162 aa overlap. ALSO highly similar to mycobacterial putative polyketide synthase: MTCY338_19, [NAME], MTCY22G10_2,MTCY19H9_2, U00023_6 M. leprae, contains PS00606 Beta-ketoacyl synthases active site
Rv3863 | Rv3863 |  | 0.9678308 | 1.0649855 | 1.1180154 | 1.1681483 | 1.1942904 | 1.1511747 | 1.3859471 | 1.4365033 | Rv3863, (MTCY01A6.05c), len: 392. Unknown
Rv3877 | Rv3877 |  | 0.8906544 | 0.8785949 | 0.90143573 | 0.9590656 | 0.925112 | 0.9508058 | 1.0116787 | 1.0229536 | Rv3877, (MTV027.12), len: 511. Unknown, highly similar to M. leprae equivalent TR:O33081 MLCB628.10C (EMBL:Y14967) (480 aa), [NAME] scores; opt: 2346, E(): 0, 74.2% identity in 480aa overlap. Also similar to M. tuberculosis hypothetical protein MTCY77.20; E(): 7e-11, 28.8% identity in 507 aa overlap