Spreadsheet: 877b31f8-9fd0-4f1c-8a08-225d919a34f6
Sheet: Sheet1

Table S8 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6
This list contains the same genes as Table S7, but the genes are colored here according to the Venn Diagram in Figure S3B (bottom).
Note that in order to qualify for 'significantly regulated', genes must have an expression fold change greater than 2 AND a p-value < 0.05.
WT+CF VS WT | t-test P-value | age3+CF vs age3 | t-test P-value | common name | systematic name | description
30.348763 | 0.0029554828 | 8.124127 | 0.033017248 | [NAME] | orf19.4082 | Immunogenic stress-associated protein; regulated by filamentous growth pathways; induced by benomyl, caspofungin, or in azole-resistant strain; [NAME], farnesol, alkaline downregulated; similar to S. cerevisiae Ddr48p
17.430733 | 0.00085759786 | 7.6696815 | 0.015185689 | RTA2 | orf19.24 | Putative floppase; required for sphingolipid long chain base release; mediates calcineurin-dependent resistance to azoles; stress-associated protein; Ca2+, calcineurin-regulated; ketoconazole, [NAME] induced; Plc1p-regulated
16.55034 | 0.00021538703 | 5.038468 | 0.03543912 | SOD5 | [NAME] | [NAME] and zinc-containing superoxide dismutase; protective role against oxidative stress; induced by neutrophil contact, hyphal growth, caspofungin, osmotic or oxidative stress; member of a gene family including SOD1, SOD4, SOD5, and SOD6
15.317691 | 0.0052558053 | 5.5616984 | 0.036877688 |  | orf19.2125 | Predicted ORF in Assemblies 19, 20 and 21
11.518946 | 0.009722099 | 10.903233 | 0.00021105401 |  | orf19.5313 | Predicted ORF from Assembly 19; merged with orf19.1430 in Assembly 20
10.548088 | 0.0012222476 | 7.843598 | 0.0026796707 | CRZ2 | orf19.2356 | Putative transcription factor; zinc finger; similar to S. cerevisiae Crz1p; homozygous crz1, not crz2, null mutation suppresses fluconazole resistance of homozygous cka2 null (defective in CK2 kinase ); Rim101p-downregulated at pH 8
10.364206 | 0.0037141396 | 21.592148 | 0.0035911913 |  | orf19.4706 | Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type; fluconazole-induced; transcription is induced in response to alpha pheromone in SpiderM medium
8.613029 | 0.01321682 | 5.0458674 | 0.008264822 | [NAME] | orf19.6595 | Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Yor049cp, which is involved in fatty acid transport; transposon mutation affects filamentous growth; alkaline downregulated; caspofungin induced
8.516965 | 2.926161e-06 | 6.083935 | 0.018329395 | CHS2 | orf19.7298 | Chitin synthase; nonessential; required for wild-type chitin deposition in hyphae; transcription is regulated during dimorphic transition; Chs1p and Chs2p, but not Chs3p, are inhibited by the protoberberine HWY-289; fungal-specific
7.282239 | 0.025416397 | 6.376933 | 0.047751855 |  | orf19.1473 | Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
6.5622416 | 0.032061636 | 6.240636 | 0.022319386 |  | orf19.6840 | Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
6.555136 | 0.00488685 | 9.111152 | 0.0014036833 | ASR1 | orf19.2344 | Protein described as similar to heat shock proteins; transcription regulated by cAMP, osmotic stress, ciclopirox olamine, ketoconazole; negatively regulated by Cyr1p, Ras1p; shows colony morphology-related gene regulation by Ssn6p
6.250733 | 0.009509265 | 4.615246 | 0.001578406 |  | orf19.753 | Predicted ORF in Assemblies 19, 20 and 21
5.9824834 | 6.779592e-06 | 3.9587646 | 0.04347853 | PI-PLC | orf19.5797 | Phosphatidylinositol (PtdIns)-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; role in, and regulated by, filamentation, Nrg1p and Tup1p; no mouse systemic virulence role; orf19.5797 and orf19.1586 are almost identical
5.8488474 | 0.0010183313 | 3.169685 | 0.01206206 | FGR22 | orf19.1586 | Putative phosphatidylinositol-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; no S. cerevisiae ortholog; role in, and regulated by, filamentation; no mouse systemic virulence role; almost identical to orf19.5797
5.36679 | 0.012904176 | 3.9716132 | 0.043683395 | CRH11 | orf19.2706 | Putative ortholog of S. cerevisiae Crh1p; predicted glycosyl hydrolase domain; similar to Csf4p, to antigenic Aspergillus fumigatus Aspf9; predicted Kex2p substrate; putative GPI-anchor; localizes to cell wall; caspofungin-induced
5.353189 | 0.010038318 | 5.1072006 | 0.001925971 | [NAME] | orf19.1727 | Vacuolar calcium P-type ATPase; transcription is regulated by calcineurin and fluconazole; mutant shows increased resistance to fluconazole or lithium, and increased sensitivity to calcium
5.3138795 | 0.039589293 | 9.4690695 | 0.00016520216 | PGA31 | orf19.5302 | Cell wall protein; putative GPI anchor; expression is regulated upon white-opaque switching; induced during cell wall regeneration; possibly spurious ORF (Annotation Working Group prediction)
5.288666 | 0.0018400518 | 2.4147804 | 0.038708124 | BMT3 | orf19.3282 | Putative beta-mannosyltransferase, required for addition of the 2nd beta-mannose to the acid-stable fraction of cell wall phosphopeptidomannan and for elongation of beta-mannose chains on the phosphopeptidomannan acid-labile fraction
5.277997 | 0.012396272 | 4.3068833 | 0.0025315417 | PGA13 | orf19.6420 | Putative GPI-anchored protein; described as similar to mucins; induced during cell wall regeneration, and during core caspofungin response; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg and by Cyr1p, Nrg1p, Tup1p, Rlm1p
5.2479773 | 0.001074911 | 3.9510326 | 0.0074883406 |  | orf19.251 | ThiJ/PfpI protein family; antigenic (Cand a 3 allergen); binds human immunoglobulin E; 2 N-glycosylation motifs; alkaline, fluconazole, Hog1p-downregulated; induced in core stress response or by oxidative stress (via Cap1p)
5.2459855 | 0.015683908 | 3.9366026 | 0.0028198552 |  | orf19.7566 | Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; alkaline upregulated by Rim101p; fungal-specific (no human or murine homolog)
5.1022515 | 5.572352e-06 | 4.7497373 | 0.006384489 | FLC2 | orf19.1813 | Protein involved in heme uptake; putative FAD transporter, similar to S. cerevisiae Flc2p
5.0533357 | 3.0773484e-05 | 2.541327 | 0.025446378 | DAG7 | orf19.4688 | Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog; a-specific transcription; alpha-factor induced
4.8607883 | 0.015752729 | 3.3220682 | 0.0053837555 |  | orf19.6877 | Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in response to treatment with caspofungin, ciclopirox olamine or ketoconazole; gene of core caspofungin response
4.732777 | 0.010782561 | 2.940715 | 0.0055494616 | [NAME] | orf19.5612 | Putative beta-mannosyltransferase, required for elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan; member of a 9-gene family; regulated by Tsa1p, Tsa1Bp
4.7249875 | 0.00922799 | 4.4115343 | 0.004342582 | ALD6 | orf19.742 | Putative aldehyde dehydrogenase; expression is regulated upon white-opaque switching; protein detected by mass spec in stationary phase cultures; transcription is upregulated in both intermediate and mature biofilms
4.583258 | 0.00018347267 | 4.2317634 | 0.013655997 | UTR2 | orf19.1671 | Putative glycosidase; cell wall; role in adhesion; required for hyphal growth on [NAME] (not serum) medium; chitin-binding, glycosyl hydrolase, GPI anchor domains; induced during cell wall regeneration; mRNA detected in yeast-form cells
4.2553215 | 0.038771767 | 3.6155965 | 0.04162023 | PGA52 | orf19.1911 | Putative GPI-anchored protein of unknown function; fluconazole-induced
4.057104 | 0.035029616 | 2.415573 | 7.054436e-05 | CRZ1 | orf19.7359 | Putative transcription factor; similar to S. cerevisiae calcineurin-regulated transcription factor [NAME]; mutant is fluconazole hypersensitive; likely to act downstream of calcineurin; has C2H2 zinc fingers; not required for mouse virulence
4.0307255 | 0.00031017748 | 3.0469356 | 0.006043048 |  | orf19.5614 | Predicted ORF in Assemblies 19, 20 and 21
3.9643824 | 5.4806314e-05 | 3.0113363 | 2.215931e-08 | IFU5 | orf19.2568 | Predicted membrane protein; estradiol-induced; increased transcription is associated with CDR1 and CDR2 overexpression or fluphenazine treatment; gene has putative drug-responsive regulatory site; similar to S. cerevisiae Wwm1p
3.8279552 | 0.017487105 | 7.3164625 | 0.0076100254 |  | orf19.4476 | Predicted ORF in Assemblies 19, 20 and 21
3.6975105 | 0.001208533 | 2.143094 | 0.000980338 |  | orf19.1632 | Predicted ORF in Assemblies 19, 20 and 21
3.6779811 | 0.019645628 | 4.0710435 | 0.0002722118 |  | orf19.6554 | Predicted ORF in Assemblies 19, 20 and 21
3.624813 | 0.008623563 | 3.2439458 | 0.00438159 | FLC1 | orf19.2501 | Protein involved in heme uptake; putative FAD transporter, similar to S. cerevisiae Flc1p; regulated by iron; macrophage-induced gene; mutant shows defect in filamentous growth
3.616632 | 0.018917214 | 2.8565965 | 0.0045240717 | PGA1 | orf19.7625 | Putative GPI-anchored protein of unknown function; induced during cell wall regeneration
3.3486204 | 0.004149261 | 2.2342248 | 0.0034203832 | [NAME] | orf19.4679 | Protein described as an amino acid permease; hyphal downregulated; regulated upon white-opaque switching; induced in core caspofungin response, during cell wall regeneration, or by flucytosine; fungal-specific (no human or murine homolog)
3.3230913 | 0.001675784 | 3.2663982 | 0.007391417 | MET13 | orf19.2887 | Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-induced; amphotericin B repressed
3.2926152 | 6.7705965e-05 | 3.0534637 | 0.016696317 |  | [NAME] | Protein similar to S. cerevisiae Sat4p; amphotericin B induced; clade-associated gene expression
3.1969535 | 0.019075878 | 3.6294634 | 0.00030604788 | HMX1 | orf19.6073 | Heme oxygenase; acts in utilization of hemin iron; gene transcriptionally activated by heat, low iron, or hemin; negatively regulated by Efg1p; expression greater in low iron; upregulated by Rim101p at pH 8
3.1272264 | 0.013141563 | 2.245391 | 0.011225865 | ROT1 | orf19.6029 | Similar to S. cerevisiae Rot1p, which is involved in cell wall 1,6-beta-glucan biosynthesis; has predicted transmembrane region
3.098998 | 0.009075197 | 2.5872254 | 0.037691124 |  | orf19.4563 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
3.069584 | 0.03679872 | 2.5854967 | 0.009958532 |  | orf19.3831 | Predicted ORF in Assemblies 19, 20 and 21
3.0226521 | 0.024642993 | 2.8830585 | 0.018864235 |  | orf19.6192 | Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; possibly spurious ORF (Annotation Working Group prediction)
3.0169234 | 0.003171297 | 3.119376 | 0.005422857 |  | orf19.6920 | Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation; possibly spurious ORF (Annotation Working Group prediction)
3.0107043 | 0.0064036194 | 3.1716106 | 0.0069222827 | CAR1 | orf19.3934 | Transcription is regulated by Nrg1p, Mig1p, and Tup1p; shows colony morphology-related gene regulation by Ssn6p; alkaline upregulated; protein level decreased in stationary phase cultures
2.9658267 | 0.03406243 | 2.2036057 | 0.0014009153 | PHR2 | orf19.6081 | Glycosidase; role in cell wall structure; may act on beta-1,3-glucan prior to beta-1,6-glucan linkage; role in vaginal but not systemic virulence (low pH, not neutral); low pH, high iron, fluconazole induced; Rim101p-downregulated at pH 8
2.9346852 | 0.000119418735 | 2.4400885 | 0.0005304196 |  | orf19.3615 | Predicted ORF in Assemblies 19, 20 and 21; induced in core caspofungin response; increased expression observed in an ssr1 homozygous null mutant; induced by nitric oxide in yhb1 mutant
2.8960164 | 0.010058961 | 2.7307281 | 0.0030910964 | CCH1 | orf19.3298 | Putative voltage-gated Ca2+ channel of the high affinity calcium uptake system; roles in thigmotropism, establishment of galvanotropism; transcription is regulated by Nrg1p and Mig1p
2.8331177 | 0.0058607925 | 2.4779742 | 0.04049865 |  | orf19.242.2 | ORF Predicted by Annotation Working Group
2.8192117 | 0.011987304 | 3.1128 | 0.020112986 | [NAME] | orf19.4765 | Putative GPI-anchored cell-wall protein of unknown function; similar to S. cerevisiae Ccw12p/Ylr110cp; transcriptionally regulated by iron; expression greater in high iron; upregulated upon Als2p depletion
2.8011148 | 0.02300813 | 2.3883507 | 0.017571826 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21
2.7641356 | 0.043149177 | 2.4826963 | 0.036337636 | CAS5 | orf19.4670 | Putative zinc finger transcription factor; cell wall damage response; required for wild-type transcriptional response to caspofungin; mutant caspofungin hypersensitive; downregulated in core stress response; avirulent, reduced CFU in mice
2.7625217 | 0.0018996457 | 4.4035153 | 0.030620161 |  | orf19.2959.1 | ORF Predicted by Annotation Working Group
2.7132978 | 0.0016142566 | 2.8408992 | 0.0007309738 | [NAME] | orf19.4183 | Protein not essential for viability; similar to S. cerevisiae Muc1p, which is a cell surface glycoprotein involved in filamentous growth; decreased transcription is observed upon benomyl treatment
2.7040207 | 0.03570539 | 3.370407 | 0.009849021 | IRS4 | orf19.6953 | Protein with roles in cell wall integrity, systemic (but not oral) murine infection, adherence, hyphal growth, and agar-embedded filamentous growth; antigenic in human infection; similar to S. cerevisiae Irs4p
2.7013557 | 0.0027033302 | 2.0284116 | 0.0211691 | SAC6 | orf19.5544 | Transcription is regulated by Nrg1p and Mig1p; protein level decreased in stationary phase cultures
2.674322 | 0.023598492 | 2.2825198 | 0.020535141 |  | orf19.7085 | Predicted ORF in Assemblies 19, 20 and 21; induced in core stress response; induced by heavy metal (cadmium) stress via Hog1p; oxidative stress-induced via Cap1p; induced by Mnl1p under weak acid stress; macrophage-downregulated
2.5788503 | 0.004058925 | 2.5521016 | 0.03747755 |  | orf19.3439 | Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type
2.568056 | 6.748876e-05 | 2.5374913 | 0.016953612 |  | orf19.1486 | Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction)
2.5244184 | 0.009174185 | 2.2086697 | 0.02582685 |  | orf19.5537 | Predicted ORF in Assemblies 19, 20 and 21
2.510556 | 0.011182223 | 3.1486235 | 0.00010971929 |  | orf19.4771 | Predicted ORF in Assemblies 19, 20 and 21
2.5025938 | 0.013289156 | 4.0294223 | 0.009262113 | SAC7 | [NAME] | Protein described as a GTPase activating protein (GAP) for [NAME]; downregulated upon adherence to polystyrene; macrophage/pseudohyphal-repressed; transcription is upregulated in RHE model of oral candidiasis and in clinical oral candidiasis
2.4869475 | 0.014286342 | 2.040727 | 0.0022712813 | PRC2 | orf19.4135 | Protein described as a carboxypeptidase; upregulated in the presence of human neutrophils
2.4843833 | 0.046336666 | 2.166743 | 0.025719551 |  | orf19.2204 | Predicted ORF in Assemblies 19, 20 and 21
2.4293158 | 0.044227205 | 6.1044936 | 0.040605318 |  | orf19.6484 | Predicted ORF in Assemblies 19, 20 and 21
2.4207542 | 0.025415367 | 3.5504236 | 0.0006820704 | HIS3 | orf19.183 | Imidazoleglycerol-phosphate dehydratase, enzyme of histidine biosynthesis; functionally complements S. cerevisiae his3-1 mutation; hyphal-induced expression; regulated by [NAME] and Gcn4p; fungal-specific (no human or murine homolog)
2.3226445 | 6.853848e-05 | 2.6091204 | 0.009902289 | INN1 | orf19.2832 | Protein with similarity to S. cerevisiae Inn1p, which is an essential protein of the contractile actomyosin ring required for ingression of the plasma membrane into the bud neck during cytokinesis; contains a C2 membrane targeting domain
2.2927125 | 0.028636359 | 2.0733166 | 0.040366627 | VPS1 | orf19.1949 | Protein described as a dynamin-family GTPase-related protein; induced upon adherence to polystyrene; regulated by [NAME] and Gcn4p
2.2743812 | 0.018975431 | 2.28168 | 0.0020927968 | ECM22 | orf19.2623 | Putative transcription factor with zinc cluster DNA-binding motif
2.267736 | 0.0012360861 | 2.2766292 | 0.020434275 | MET15 | orf19.5645 | O-acetylhomoserine O-acetylserine sulfhydrylase; involved in sulfur amino acid biosynthesis; immunogenic; Hog1p, biofilm, possibly adherence-induced; brown colony color of homozygous mutant in Pb(2+) medium is visual selection marker
2.2494564 | 0.008913354 | 2.0627568 | 0.0118309455 |  | orf19.5495 | Protein not essential for viability; transcription is induced in response to alpha pheromone in SpiderM medium
2.2480042 | 0.030921992 | 3.7743845 | 0.012864529 | CHO1 | orf19.677 | Putative phosphatidylserine synthase; similar to S. cerevisiae Cho1p, which is involved in phosphatidylserine biosynthesis; transposon mutation affects filamentous growth; regulated by Nrg1p, Tup1p; no human or murine homolog
2.2271786 | 0.046001144 | 2.5894237 | 0.00049923937 |  | orf19.7354 | Predicted ORF in Assemblies 19, 20 and 21; caspofungin induced
2.2055233 | 0.020919528 | 2.0681536 | 0.0019039784 |  | orf19.7583 | Putative transcription factor with zinc cluster DNA-binding motif; not essential for viability; filament induced
2.204474 | 0.0035957622 | 2.066199 | 0.0001592629 | MXR1 | orf19.2028 | Protein described as a methionine sulfoxide reductase; flucytosine induced; Plc1p-regulated; upregulated in the presence of human neutrophils; macrophage regulated (gene induced, protein decreased); possibly adherence-induced
2.1790864 | 0.010602548 | 2.2014978 | 0.00053860835 | FAD3 | orf19.4933 | Omega-3 fatty acid desaturase, involved in production of alpha-linolenic acid, which is a major component of membranes; caspofungin induced; Plc1p-regulated; shows colony morphology-related gene regulation by Ssn6p
2.1613057 | 0.0030950757 | 2.395827 | 0.0015240334 |  | orf19.5045 | Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress
2.1355183 | 0.043216012 | 3.192203 | 0.0019191562 | REI1 | orf19.59 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
2.1238647 | 0.002858718 | 2.1807272 | 0.001466211 | AMS1 | orf19.2768 | Putative alpha-mannosidase; transcription is regulated by Nrg1p; induced during cell wall regeneration
2.0501556 | 0.004404547 | 2.2949622 | 0.0021031322 | AKR1 | orf19.4950 | Ankyrin-repeat protein; increased transcription is observed upon fluphenazine treatment
2.0065465 | 0.0040481887 | 2.0524247 | 0.0013098497 | FOX3 | orf19.1704 | Putative peroxisomal 3-oxoacyl CoA thiolase; expression is regulated upon white-opaque switching
0.49958333 | 0.036458652 | 0.4661439 | 0.000517618 | MDH1-3 | orf19.5323 | Predicted malate dehydrogenase; farnesol regulated
0.49835938 | 0.0058439006 | 0.4913282 | 0.00017031288 |  | orf19.1172 | Protein similar to phosphate transporters; regulated upon white-opaque switching or biofilm formation; Hog1p, ciclopirox olamine or alkaline induced; caspofungin or stress repressed; merged with orf19.655 in Assembly 20
0.49803567 | 0.008006836 | 0.31924424 | 0.023140047 | SUR2 | orf19.5818 | Protein described as similar to ceramide hydroxylase; predicted enzyme of sphingolipid biosynthesis; upregulated in biofilm; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions
0.49719265 | 0.00045025398 | 0.29216734 | 0.004061338 | GCV2 | orf19.385 | Putative protein of glycine catabolism; downregulated by Efg1p; Hog1p-induced; upregulated by Rim101p at acid pH; transcription is activated in the presence of elevated CO2; protein detected by mass spec in stationary phase cultures
0.49425712 | 0.03828502 | 0.39902037 | 0.019389352 | XKS1 | orf19.1290 | Predicted ORF in Assemblies 19, 20 and 21; increased expression in response to prostaglandins
0.4868477 | 0.0024300714 | 0.4569183 | 0.019077934 |  | orf19.3175 | Predicted ORF in Assemblies 19, 20 and 21; alkaline downregulated; repressed by nitric oxide; virulence-group-correlated expression
0.48240423 | 0.014772329 | 0.38474315 | 0.046933718 | FMP27 | orf19.3422 | Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog)
0.48045638 | 0.0066765943 | 0.43439743 | 0.0021431262 |  | orf19.4185 | Predicted ORF in Assemblies 19, 20 and 21
0.4768771 | 0.012049179 | 0.47277796 | 0.00019159738 | PTR2 | orf19.6937 | Putative oligopeptide transporter; regulated by Stp2p and Stp3p; transcriptionally induced upon phagocytosis by macrophage; downregulated by Rim101p at pH 8
0.47410733 | 0.03991145 | 0.41449606 | 0.02245734 |  | orf19.3364 | Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction)
0.47098738 | 0.010679897 | 0.44126818 | 0.002366813 | CAF16 | orf19.388 | ABC family protein, predicted not to be a transporter; [NAME] repressed
0.46868983 | 0.0010994098 | 0.4647538 | 0.009525454 |  | orf19.6770 | Predicted ORF in Assemblies 19, 20 and 21
0.46374467 | 0.009859431 | 0.4105178 | 0.011140995 |  | orf19.5293 | Predicted ORF in Assemblies 19, 20 and 21
0.46185136 | 0.00032728224 | 0.4503451 | 0.015957605 |  | orf19.3004 | Predicted ORF in Assemblies 19, 20 and 21
0.46033567 | 0.044036355 | 0.32988715 | 0.0025390487 |  | orf19.4738 | Predicted ORF in Assemblies 19, 20 and 21
0.4586014 | 0.0009927002 | 0.35904378 | 0.00024476924 | PGA48 | orf19.6321 | Putative GPI-anchored protein of unknown function; similar to S. cerevisiae Spi1p, which is induced at stationary phase; transcriptionally regulated by iron; expression greater in high iron
0.45801294 | 0.027004778 | 0.3502704 | 0.031988144 | PHO84 | orf19.655 | Protein similar to high-affinity phosphate transporters; expression is regulated upon white-opaque switching or biofilm formation; Hog1p, ciclopirox olamine or alkaline induced; caspofungin or stress repressed; upregulated in RHE model
0.45782298 | 0.016256412 | 0.2075196 | 0.00063909515 | SCW11 | orf19.3893 | Cell wall protein; transcription is decreased in mutant lacking [NAME]; downregulated in core caspofungin response; transcriptionally regulated by iron; expression greater in high iron
0.4563012 | 0.0011126201 | 0.4287367 | 0.0016747281 | MIG1 | orf19.4318 | Transcriptional repressor; regulates genes for utilization of carbon sources; Tup1p-dependent and -independent functions; upregulated in biofilm; hyphal downregulated; [NAME] repressed; functional homolog of S. cerevisiae Mig1p
0.4560062 | 0.0313738 | 0.4716832 | 3.086585e-05 |  | orf19.846 | Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress
0.45057642 | 0.03708171 | 0.44811437 | 0.00052309723 | [NAME] | orf19.4195.1 | Cytosine deaminase; enzyme of pyrimidine salvage; functional homolog of S. cerevisiae Fcy1p; mutation is associated with resistance to flucytosine (5-FC) in a clinical isolate; hyphal downregulated; gene has intron
0.44920862 | 4.173099e-05 | 0.43874708 | 0.0036820087 | CDC20 | orf19.122 | Protein similar to S. cerevisiae Cdc20p, which is a cell-cycle regulated activator of the anaphase promoting complex; induced under Cdc5p depletion; member of conserved Mcm1p regulon; periodic mRNA expression, peak at cell-cycle G2/M phase
0.44826254 | 0.0028188617 | 0.49903584 | 0.034329005 |  | orf19.2261 | Predicted ORF in Assemblies 19, 20 and 21
0.44682434 | 0.0031643896 | 0.31130424 | 0.0053450908 |  | orf19.7459 | Predicted ORF in Assemblies 19, 20 and 21; fluconazole-induced; ketoconazole-repressed
0.44537985 | 0.0011791766 | 0.3748606 | 0.0046119257 |  | orf19.5282 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in hyphae compared to yeast-form cells; regulated by Efg1p and Efh1p; intron in 5'-UTR; transcriptionally activated by Mnl1p under weak acid stress
0.43830004 | 0.0065707727 | 0.39353997 | 0.012397251 |  | orf19.2414 | Predicted ORF in Assemblies 19, 20 and 21
0.43407208 | 0.026765766 | 0.40094954 | 0.03442296 |  | orf19.951 | Predicted ORF in Assemblies 19, 20 and 21; transcription downregulated upon yeast-hyphal switch; fluconazole-induced; possibly spurious ORF (Annotation Working Group prediction)
0.43319443 | 0.000464275 | 0.36334264 | 0.0050640022 |  | orf19.6816 | Predicted ORF in Assemblies 19, 20 and 21
0.4267928 | 0.02070912 | 0.46799722 | 0.0039794324 | PTC8 | orf19.4698 | Predicted type 2C protein phosphatase, serine/threonine-specific; required for hyphal growth; induced under stress
0.4259395 | 0.0056045316 | 0.39441574 | 3.6138354e-05 |  | orf19.5334 | Predicted ORF in Assemblies 19, 20 and 21; transcription regulated upon yeast-hyphal switch
0.41910246 | 0.0017381185 | 0.45882955 | 0.020912936 |  | orf19.6983 | Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide
0.41872215 | 0.005449375 | 0.34804222 | 0.010518065 |  | orf19.3302 | Predicted ORF in Assemblies 19, 20 and 21; transcription downregulated upon yeast-hyphal switch; transcriptionally activated by Mnl1p under weak acid stress
0.41367024 | 0.0014417503 | 0.42542347 | 0.03521051 | PGA53 | orf19.4651 | Putative GPI-anchored protein of unknown function; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type
0.4088575 | 0.01136028 | 0.34169522 | 0.007707224 |  | orf19.4450.1 | ORF Predicted by Annotation Working Group
0.40773854 | 0.0108704055 | 0.41150275 | 0.0031246487 | PHO15 | orf19.4444 | Protein described as 4-nitrophenyl phosphatase; hyphal downregulated; induced in core stress response; induced by heavy metal (cadmium) stress via Hog1p
0.40028128 | 0.0053041195 | 0.39155212 | 0.00504139 |  | orf19.2658 | Predicted ORF from Assembly 19; merged with orf19.1352 in Assembly 20
0.3905495 | 0.0018777864 | 0.44049332 | 0.009226458 | CTA9 | orf19.3315 | Protein induced during the mating process; activates transcription in 1-hybrid assay in S. cerevisiae
0.39046904 | 0.00014626989 | 0.33822313 | 4.9028862e-05 | RIB3 | [NAME] | 3,4-Dihydroxy-2-butanone 4-phosphate synthase; homodimeric enzyme of riboflavin biosynthesis; converts ribulose 5-phosphate to L-3,4-dihydroxy-2-butanone 4-phosphate; transcription regulated on yeast-hyphal switch, macrophage interaction
0.389388 | 0.00580854 | 0.36424565 | 0.013640719 | RAD16 | orf19.2969 | Protein similar to S. cerevisiae Rad16p; flucytosine induced
0.38668296 | 0.00020287198 | 0.30379742 | 0.00018507769 | PDX3 | orf19.550 | Transcription is regulated upon yeast-hyphal switch; regulated by Nrg1p, Mig1p, and Tup1p; [NAME] repressed; protein detected by mass spec in exponential and stationary phase cultures
0.3823355 | 0.007117097 | 0.26867107 | 0.012959343 | QDR1 | orf19.508 | Putative transporter of antibiotic resistance; transcription is regulated by Nrg1p and Tup1p; [NAME] repressed; expression is regulated upon white-opaque switching
0.3806331 | 0.0016425234 | 0.34837148 | 0.001098515 |  | orf19.3448 | Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-repressed; possibly spurious ORF (Annotation Working Group prediction)
0.38001648 | 0.012095371 | 0.44854805 | 0.014028477 | PCL7 | orf19.6225 | Protein described as cyclin-like, possible Pho85p cyclin; hyphal downregulated; transcriptionally activated by Mnl1p under weak acid stress
0.37994578 | 1.02528575e-05 | 0.13346376 | 1.534215e-07 | FGR41 | orf19.4910 | Putative GPI-anchored protein; transposon mutation affects filamentous growth; possibly spurious ORF (Annotation Working Group prediction)
0.37760392 | 9.1790374e-05 | 0.42745343 | 0.012894197 |  | orf19.2125.1 | ORF Predicted by Annotation Working Group; removed from Assembly 20
0.3768348 | 0.022437595 | 0.3375747 | 0.02265839 | UCF1 | orf19.1354 | Transcriptionally regulated by iron or by yeast-hyphal switch; expression greater in high iron, decreased upon yeast-hyphal switch; downregulation correlates with clinical development of fluconazole resistance; Ras1p-regulated
0.36311838 | 0.0006034675 | 0.30466664 | 0.0236821 |  | orf19.7227 | Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog
0.36125982 | 0.0026259788 | 0.33528996 | 0.00019778969 |  | orf19.6119 | Predicted ORF in Assemblies 19, 20 and 21
0.3590428 | 0.037926476 | 0.22645053 | 8.1367674e-05 |  | orf19.2048 | Transcription is positively regulated by Sfu1p
0.35887364 | 0.021687146 | 0.43131188 | 0.032595515 |  | orf19.1653 | Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction)
0.3587896 | 0.04974962 | 0.29471633 | 0.0039215502 | TPS2 | orf19.3038 | Trehalose-6-phosphate (Tre6P) phosphatase; mutation causes heat sensitivity, Tre6P accumulation, and decreased mouse virulence; possible drug target; two conserved phospohydrolase motifs; no human or murine homolog
0.35645595 | 0.04294161 | 0.31426176 | 0.04423577 | BUB3 | orf19.2655 | Protein similar to S. cerevisiae Bub3p, which is a kinetochore checkpoint component; induced under hydroxyurea treatment
0.3528407 | 0.046776336 | 0.26958197 | 0.0019724532 |  | orf19.2659 | Predicted ORF from Assembly 19; downregulation correlates with clinical development of fluconazole resistance; decreased expression in hyphae compared to yeast-form cells; Ras1p-regulated; merged with orf19.1354 in Assembly 20
0.34421912 | 0.040699787 | 0.34239718 | 0.002286907 |  | orf19.4013 | Predicted ORF in Assemblies 19, 20 and 21
0.34175608 | 0.008396501 | 0.35548896 | 7.727762e-05 |  | orf19.1381 | Predicted ORF in Assemblies 19, 20 and 21
0.34113958 | 4.033517e-08 | 0.3219811 | 0.0009786418 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21
0.33635756 | 0.032545146 | 0.22834322 | 0.004391227 | DAK2 | orf19.4777 | Protein described as similar to dihydroxyacetone kinase; transcription is decreased upon yeast-hyphal switch; fluconazole-induced; [NAME] repressed; protein detected by mass spec in stationary phase cultures
0.33393317 | 0.03655556 | 0.2635654 | 8.32959e-05 | MAF1 | orf19.2173 | Protein described as affecting nucleocytoplasmic transport and synthesis of RNA Polymerase III; decreased expression in hyphae compared to yeast-form cells; [NAME] repressed
0.33292112 | 0.019036083 | 0.24080324 | 0.018149769 | [NAME] | orf19.3656 | Transcription is regulated by Nrg1p and Tup1p; alkaline downregulated
0.3292037 | 0.042441063 | 0.28567427 | 0.002456299 | CMK1 | orf19.5911 | Expression is regulated upon white-opaque switching; biochemically purified Ca2+/CaM-dependent kinase is soluble, cytosolic, monomeric, and serine-autophosphorylated
0.32697767 | 4.9682396e-05 | 0.26013958 | 0.0010645814 | [NAME] | orf19.3278 | Protein described as glycogen synthase; enzyme of glycogen metabolism; transcription downregulated upon yeast-hyphal switch and regulated by Efg1p; strong oxidative stress induced; shows colony morphology-related gene regulation by Ssn6p
0.32037836 | 0.0021185952 | 0.34495637 | 0.011682603 | ERG3 | orf19.767 | C-5 sterol desaturase; introduces C-5(6) double bond into episterol in ergosterol biosynthesis; clinically-isolated homozygous null mutants show azole resistance, defects in hyphal growth and virulence; Efg1p-repressed; fluconazole-induced
0.31770763 | 0.020448307 | 0.36453938 | 0.035252005 | CBF1 | orf19.2876 | Transcription factor that binds to a conserved sequence at ribosomal protein genes and the rDNA locus, with Tbf1p; also regulates sulfur starvation-response and other genes; binds centromeres and has a role in centromere maintenance
0.31306788 | 0.013504587 | 0.28428292 | 0.00046347862 | MSN4 | orf19.4752 | Putative zinc finger transcription factor; similar to S. cerevisiae Msn4p, but not a significant stress response regulator in C. albicans; partly complements STRE-activation defect of S. cerevisiae msn2 msn4 double mutant
0.31172392 | 0.033328258 | 0.27122936 | 0.0056890706 | HEM13 | orf19.2803 | Coproporphyrinogen III oxidase; antigenic in human, mouse; localizes to yeast-form cell surface, not hyphae; soluble in hyphae; iron-regulated expression; macrophage-downregulated protein; not Rfg1p regulated, farnesol-induced
0.3073995 | 0.0052762358 | 0.33115032 | 0.0029271157 |  | orf19.2223 | Predicted ORF from Assembly 19; removed from Assembly 20
0.3063148 | 0.0022401144 | 0.30003726 | 0.0020242746 |  | [NAME] | Predicted ORF from Assembly 19; merged with orf19.2866 in Assembly 20
0.28706756 | 0.020877115 | 0.22013174 | 0.04611718 | TPO3 | orf19.4737 | Possible role in polyamine transport; MFS-MDR family; transcription induced by Sfu1p, regulated upon white-opaque switching; decreased expression in hyphae compared to yeast-form cells; regulated by Nrg1p; fungal-specific
0.2857035 | 0.016475782 | 0.2584426 | 0.018521722 | FET34 | orf19.4215 | Protein similar to multicopper ferroxidase; expression greater in low iron and reduced in a fluconazole-resistant isolate; downregulated by Sfu1p, Hog1p; alkaline upregulated by Rim101p; ciclopirox olamine induced
0.2779241 | 0.009417992 | 0.13401951 | 0.0004636419 | PGA38 | orf19.2758 | Putative GPI-anchored protein of unknown function; repressed during cell wall regeneration
0.27428 | 0.0007912598 | 0.26219735 | 0.009956836 | MAE1 | [NAME] | Malic enzyme, mitochondrial; transcription regulated by Mig1p and Tup1p; shows colony morphology-related gene regulation by Ssn6p
0.26876774 | 0.004461973 | 0.33438686 | 0.03254456 |  | orf19.2866 | Predicted ORF in Assemblies 19, 20 and 21
0.2593295 | 0.00021357073 | 0.29772502 | 0.02408652 |  | orf19.3820 | Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression
0.25600266 | 0.00014273296 | 0.2679407 | 0.024442542 | ERG1 | orf19.406 | Squalene epoxidase, catalyzes epoxidation of squalene to 2,3(S)-oxidosqualene in the ergosterol biosynthetic pathway; essential; target of allylamine antifungal drugs; uses NADH as a reducing cofactor, while S. cerevisiae Erg1p uses NADPH
0.24326801 | 5.351327e-06 | 0.27446398 | 0.0010863992 |  | orf19.7396 | Predicted ORF in Assemblies 19, 20 and 21
0.24180937 | 0.012260687 | 0.31805933 | 0.0047800783 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21
0.23523526 | 0.013503813 | 0.34952223 | 0.013076252 | SYG1 | [NAME] | Protein not essential for viability; similar to S. cerevisiae Syg1p, which is a plasma membrane protein that may be involved in signal transduction
0.20612183 | 7.8626756e-05 | 0.11839119 | 0.021954529 | [NAME] | orf19.7586 | Chitinase, major; functional homolog of S. cerevisiae Cts1p; 4 N-glycosylation motifs; possible O-mannosylated region; putative signal peptide; hyphal-repressed; farnesol upregulated in biofilm; regulated by Efg1p, Cyr1p, Ras1p
0.2006374 | 0.023015514 | 0.12780175 | 0.00018589558 |  | orf19.670.2 | ORF Predicted by Annotation Working Group
0.19217211 | 0.011031903 | 0.22362427 | 0.00039662508 | FRE10 | orf19.1415 | Major cell-surface ferric reductase under low-iron conditions; 7 transmembrane regions and a secretion signal predicted; repressed by Tup1p, Rim101p, Ssn6p, Hog1p, caspofungin; ciclopirox olamine induced; not required for filamentous growth
0.1888397 | 0.0006050968 | 0.15700036 | 3.8113172e-05 | IFE2 | orf19.5288 | Protein described as an alcohol dehydrogenase; decreased expression in hyphae compared to yeast-form cells; Efg1p-regulated; fluconazole-induced; Hog1p-induced; increased expression in response to prostaglandins
0.18282996 | 0.015410599 | 0.08351415 | 0.0028572606 |  | orf19.5267 | Putative cell wall protein; downregulated in core caspofungin response; transcription is repressed in response to alpha pheromone in SpiderM medium; transcription repressed in ace2 null mutant
0.1561372 | 0.002825068 | 0.16945897 | 0.0052426276 | CDR4 | orf19.5079 | Putative transporter of ATP-binding cassette (ABC) superfamily; fluconazole, Sfu1p, Hog1p, core stress response induced; [NAME]; fluconazole resistance is not affected by mutation or correlated with expression
0.15320598 | 0.00579381 | 0.14886455 | 0.00058118126 | RNR22 | orf19.1868 | Protein described as ribonucleoside diphosphate reductase; shows colony morphology-related gene regulation by Ssn6p; RNA abundance regulated by tyrosol and cell density
0.13723235 | 0.0024513516 | 0.17398725 | 0.029423524 | HGT6 | orf19.2020 | Putative glucose transporter of major facilitator superfamily; 20 members of C. albicans glucose transporter family; 12 probable membrane-spanning segments; core stress response, fluconazole-induced; expressed in rich medium with 2% glucose
WT+CF VS WT | t-test P-value | age3+CF vs age3 | t-test P-value | common name | systematic name | description
12.222304 | 0.0067945905 | 8.800638 | 0.053781312 |  | orf19.1765 | Predicted ORF in Assemblies 19, 20 and 21
9.906688 | 0.020897904 | 7.2683206 | 0.08699828 |  | orf19.675 | Similar to cell wall proteins; induced in core stress response, core caspofungin response; iron-regulated; amphotericin B induced; regulated by Cyr1p, Ssn6p; possibly spurious ORF (Annotation Working Group prediction)
6.4996886 | 0.0024260385 | 3.8710246 | 0.052460033 |  | orf19.2030 | Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type
6.3491364 | 0.0038428227 | 3.5796711 | 0.1001633 | SAP9 | orf19.6928 | Secreted aspartyl proteinase; roles in adhesion, cell surface integrity; induced by antifungal drugs, stationary phase, or in white-phase cells; farnesol-downregulated in biofilm; autocatalytic processing; GPI-anchor; N-glycosylated
6.271349 | 0.00699716 | 3.5944412 | 0.079909444 | ALS1 | orf19.5741 | [NAME]; ALS family of cell-surface glycoproteins; adhesion, virulence roles; immunoprotective; in band at hyphal base; amyloid domain; biofilm-induced; Rfg1p, Ssk1p, growth-regulated; strain background affects expression
5.790668 | 8.6698696e-05 | 5.1261697 | 0.06894313 |  | orf19.2726 | Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated
4.3430605 | 0.00049953 | 1.5489705 | 0.11696522 | PUT1 | orf19.4274 | Alkaline upregulated by Rim101p
3.9698887 | 0.0050146114 | 3.659122 | 0.05450469 |  | orf19.6264.3 | ORF Predicted by Annotation Working Group
3.8738575 | 0.0018745849 | 1.8375864 | 0.15842718 | ENA21 | orf19.5170 | Predicted ORF similar to S. cerevisiae sodium transporters Ena1p and Ena5p; Gcn4p-regulated; flucytosine, amphotericin B, or ketoconazole-induced; osmotic stress-induced; overlaps orf19.5170.1, which is annotated as a blocked reading frame
3.6531665 | 0.005231933 | 2.8409085 | 0.05857651 | CRL1 | orf19.3330 | Predicted GTPase of RHO family; CAAX motif geranylgeranylated; expression in S. cerevisiae causes dominant-negative inhibition of pheromone response
3.1682966 | 0.003980299 | 2.8213382 | 0.160428 | WH11 | orf19.3548.1 | Cytoplasmic protein expressed specifically in white phase yeast-form cells; expression in opaque cells increases virulence and frequency of opaque-to-white switching; null mutant shows wild-type switching; similar to S. cerevisiae Hsp12p
2.9383392 | 0.023253102 | 1.3739855 | 0.24500069 |  | orf19.7350 | Soluble protein in hyphae; fluconazole-induced; mRNA abundance is elevated in a cyr1 or ras1 null mutant and decreased mRNA abundance in an efg1 null mutant; regulated by Nrg1p, Tup1p, Tbf1p, Ssn6p
2.8244095 | 2.2640386e-05 | 1.1014196 | 0.64886785 | PUT2 | orf19.3974 | Alkaline upregulated; protein detected by mass spec in exponential and stationary phase cultures
2.6362274 | 0.042555016 | 2.469289 | 0.07102771 | KTR4 | orf19.4475 | Protein with similarity to mannosyltransferases; induced during cell wall regeneration; fungal-specific (no human or murine homolog)
2.6332057 | 0.043060746 | 2.2378335 | 0.07386462 | CEK1 | orf19.2886 | ERK-family protein kinase, required for wild-type yeast-hyphal switching, mating efficiency, and virulence in a mouse model; Cst20p-Hst7p-Cek1p-Cph1p MAPK pathway regulates mating, and invasive hyphal growth under some conditions
2.6251628 | 0.0010616924 | 1.980613 | 0.07880248 |  | orf19.1809 | Predicted 3-hydroxyacyl-CoA epimerase; upregulated upon phagocytosis; transcription is regulated by Mig1p; expression is regulated upon white-opaque switching; merged with orf19.1288 in Assembly 20
2.604817 | 0.047660634 | 1.7693262 | 0.15865572 |  | orf19.5037 | Protein not essential for viability
2.5901263 | 8.259461e-05 | 2.582415 | 0.057285264 |  | orf19.3438 | Predicted ORF in Assemblies 19, 20 and 21
2.5178814 | 0.035405878 | 2.1426914 | 0.07585845 | [NAME] | orf19.5995 | Putative cysteine protease with similarity to S. cerevisiae Mca1p; has a role in apoptotic cell death upon [NAME] treatment; fungal-specific (no human or murine homolog); farnesol-induced
2.4897523 | 0.04432702 | 2.3656864 | 0.07376586 | OPY2 | orf19.5110 | Predicted ORF in Assemblies 19, 20 and 21
2.4848979 | 0.049741663 | 2.3099282 | 0.06742871 | SCP1 | orf19.17 | Predicted ORF in Assemblies 19, 20 and 21; constitutive expression independent of MTL or white-opaque status
2.4048898 | 0.040805075 | 1.6836157 | 0.046980575 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; possibly spurious ORF (Annotation Working Group prediction)
2.3887475 | 0.00029574314 | 1.8620216 | 0.01801806 | HUT1 | orf19.6803 | Predicted ORF in Assemblies 19, 20 and 21
2.355913 | 0.0020091813 | 1.6147379 | 0.16099109 | ENA2 | orf19.6070 | Protein described as sodium transporter; transcription is upregulated in response to ciclopirox olamine; alkaline upregulated by Rim101p; repressed upon high-level peroxide stress; upregulated in oral candidiasis clinical isolates
2.2967002 | 0.00012710302 | 1.7165105 | 0.07249761 | [NAME] | [NAME] | Protein involved in sphingolipid biosynthesis; required for mannosylation of inositol phosphoceramide (IPC) to form mannosylated sphingolipids [NAME] and M(IP)2C; fluconazole, caspofungin induced; macrophage-downregulated gene
2.2871614 | 0.042587414 | 2.2414508 | 0.12631266 |  | orf19.1766 | Predicted ORF in Assemblies 19, 20 and 21
2.2760618 | 0.0034406888 | 1.445928 | 0.005449065 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21; induced in core caspofungin response; increased expression observed in an ssr1 homozygous null mutant; induced by nitric oxide in yhb1 mutant
2.2695272 | 0.013459668 | 1.7124382 | 0.24608967 | BGL2 | orf19.4565 | 1,3-beta-Glucosyltransferase, cell wall enzyme; one of multiple 1,3-beta-glucosyltransferases; mutant has cell-wall and growth defects, but wild-type 1,3- or 1,6-beta-glucan content; antigenic; virulence role in mouse systemic infection
2.2646608 | 0.04688363 | 2.8162887 | 0.05686006 |  | orf19.1642 | Predicted ORF in Assemblies 19, 20 and 21
2.2514186 | 0.004792942 | 1.8916864 | 0.071662724 |  | orf19.6474 | Predicted ORF in Assemblies 19, 20 and 21
2.2490091 | 0.00057356624 | 1.8814588 | 0.0007052128 | [NAME] | orf19.2699 | Protein similar to S. cerevisiae Abp1p, which is an actin-binding protein of the cortical actin cytoskeleton; caspofungin induced; protein detected by mass spec in stationary phase cultures
2.19712 | 0.01306635 | 1.3744885 | 0.0012464343 | SOU1 | orf19.2896 | Enzyme involved in utilization of L-sorbose; has sorbitol dehydrogenase, fructose reductase, and sorbose reductase activities; has NAD-binding site motif; transcriptional regulation affected by chromosome 5 copy number
2.1895587 | 0.020344686 | 1.5040867 | 0.15929963 |  | orf19.727 | Predicted ORF in Assemblies 19, 20 and 21; member of a family encoded by [NAME]-related genes in the RB2 repeat sequence; possibly spurious ORF (Annotation Working Group prediction)
2.1671102 | 0.0005688019 | 1.577713 | 0.14805214 |  | orf19.5250 | Predicted ORF in Assemblies 19, 20 and 21
2.1543329 | 0.00187998 | 2.4323893 | 0.050286204 |  | orf19.1139 | Predicted ORF in Assemblies 19, 20 and 21
2.138891 | 5.653113e-06 | 1.8580406 | 0.15175775 | BMT6 | orf19.5602 | Putative beta-mannosyltransferase, member of a 9-gene family that includes characterized genes BMT1, [NAME], BMT3, and [NAME] with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; predicted ORF in Assemblies 19, 20 and 21
2.133835 | 0.0007948865 | 1.6027666 | 0.0047309846 | PRO3 | [NAME] | Protein induced during the mating process; alkaline upregulated
2.1254165 | 0.013250163 | 2.0636709 | 0.06423158 |  | orf19.3815 | Predicted ORF in Assemblies 19, 20 and 21
2.1229985 | 0.011205327 | 1.9452046 | 0.06580135 | CNS1 | orf19.6052 | Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to radicicol
2.1218317 | 0.0012474059 | 1.7874432 | 0.043706935 |  | orf19.3007.2 | ORF Predicted by Annotation Working Group
2.1061885 | 0.039996807 | 1.9728754 | 0.05640295 |  | orf19.5924 | Predicted zinc-finger protein of unknown function
2.10546 | 0.003185755 | 1.7277054 | 0.12385332 |  | orf19.7495 | Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide
2.0990882 | 0.033978906 | 1.7353106 | 0.14624174 |  | orf19.246 | Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog)
2.0969846 | 0.01808828 | 1.4970636 | 0.020207804 | SSR1 | orf19.7030 | Beta-glucan associated cell-wall protein with role in cell wall structure; S/T rich protein, GPI anchor; similar mRNA abundance in yeast-form and germ tube; detected at germ tube plasma membrane by mass spec; similar to S. cerevisiae Ssr1p
2.090006 | 0.001890997 | 1.7177606 | 0.04663551 |  | orf19.14 | Predicted ORF from Assembly 19; removed from Assembly 20
2.0891328 | 0.019301271 | 2.155844 | 0.085796274 |  | orf19.5431 | Predicted ORF in Assemblies 19, 20 and 21
2.0824208 | 0.0022841808 | 1.966059 | 0.048894063 |  | orf19.158 | Predicted ORF in Assemblies 19, 20 and 21
2.0798783 | 0.035365645 | 1.9161639 | 0.042518117 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21
2.0661738 | 0.021316664 | 1.8597447 | 0.06035943 |  | orf19.3501 | Predicted ORF in Assemblies 19, 20 and 21; Hog1p-downregulated
2.0628226 | 6.703258e-05 | 1.5161996 | 0.028729107 | SEC18 | orf19.4993 | Functional homolog of S. cerevisiae Sec18p, which acts in protein transport; conserved ATP binding site; not glycosylated
2.0508323 | 0.0025566167 | 2.4511986 | 0.05854553 | [NAME] | orf19.5025 | Putative ATP sulfurlyase of sulfate assimilation; repressed by Met or [NAME], Sfu1p, or in fluconazole-resistant isolate; strongly induced on biofilm formation, even in presence of Met and [NAME]; Hog1p-, caspofungin-, possibly adherence-induced
2.0332491 | 0.01051463 | 1.6012306 | 0.0552431 | BMT5 | orf19.1464 | Putative beta-mannosyltransferase, member of a 9-gene family that includes characterized genes BMT1, [NAME], BMT3, and [NAME] with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; predicted ORF in Assemblies 19, 20 and 21
2.018132 | 0.017951736 | 1.8413825 | 0.045681898 |  | orf19.7531 | Predicted ORF in Assemblies 19, 20 and 21; transcription is induced upon yeast-hyphal transition; benomyl or caspofungin induced; protein detected by mass spec in stationary phase cultures
0.49577934 | 3.2772383e-05 | 0.5334233 | 1.8870196e-05 | ACS1 | orf19.1743 | Putative acetyl-CoA synthetase, similar to S. cerevisiae Acs1p; upregulated in the presence of human neutrophils; fluconazole-downregulated; regulated by Nrg1p and Mig1p; shows colony morphology-related gene regulation by Ssn6p
0.4945748 | 7.7475124e-05 | 0.5347172 | 0.0038960862 |  | orf19.3881 | Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction)
0.4897612 | 0.025611037 | 0.62145656 | 0.06861019 | LEU1 | orf19.7498 | Protein described as 3-isopropylmalate dehydratase; antigenic in human; decreased expression in hyphae compared to yeast-form cells; alkaline downregulated; upregulated in the presence of human whole blood or polymorphonuclear (PMN) cells
0.4886887 | 0.03212984 | 0.4375879 | 0.093813315 | IDP2 | orf19.3733 | Putative isocitrate dehydrogenase; expression is regulated upon white-opaque switching; shows colony morphology-related gene regulation by Ssn6p; protein detected by mass spec in exponential and stationary phase cultures
0.4832665 | 0.0011004619 | 0.6722261 | 0.059542045 |  | orf19.822 | Protein detected in some, not all, biofilm extracts; fluconazole-downregulated; greater mRNA abundance observed in cyr1 or ras1 homozygous null mutant than in wild type; protein detected by mass spec in stationary phase cultures
0.48249394 | 0.046266742 | 0.5239277 | 0.06709664 |  | orf19.3406 | Predicted ORF in Assemblies 19, 20 and 21; member of conserved Mcm1p regulon
0.4765929 | 0.03106616 | 0.57831305 | 0.16065362 | XYL2 | orf19.7676 | Protein described as similar to D-xylulose reductase; immunogenic in mouse; soluble protein in hyphae; Hog1p-induced; induced during cell wall regeneration; caspofungin or fluconazole-induced; Mnl1p-induced in weak acid stress
0.47580636 | 0.014525355 | 0.41091135 | 0.050274983 | RHD3 | orf19.5305 | Putative GPI-anchored protein that localizes to the cell wall; transcription is decreased upon yeast-hyphal switch; transcriptionally regulated by iron; expression greater in high iron; clade-associated gene expression
0.4676785 | 0.023556247 | 0.60706294 | 0.07127426 |  | orf19.1189 | Predicted ORF in Assemblies 19, 20 and 21; transcription regulated upon yeast-hyphal switch; transcriptionally activated by Mnl1p under weak acid stress
0.46395278 | 0.016092721 | 0.43505678 | 0.06594499 |  | orf19.4998 | Predicted ORF in Assemblies 19, 20 and 21; [NAME] repressed
0.45851052 | 0.035630293 | 0.45146632 | 0.08337521 | EAF6 | orf19.396 | Subunit of the NuA4 histone acetyltransferase complex
0.4524146 | 0.0131409215 | 0.56352806 | 0.03214246 |  | orf19.6978 | Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction)
0.45241424 | 0.048133966 | 0.4095938 | 0.08630359 | [NAME] | [NAME] | Protein similar to phosphate permeases; transcription is negatively regulated by Rim101p at pH 8; expression is regulated upon white-opaque switching; [NAME] repressed; biofilm-regulated; virulence-group-correlated expression
0.450901 | 0.0024598406 | 0.50508034 | 0.00017643734 |  | orf19.7473 | Predicted ORF in Assemblies 19, 20 and 21
0.44940725 | 0.035729334 | 0.5366325 | 0.0047407895 |  | orf19.6833 | Predicted ORF from Assembly 19; merged with orf19.6832 in Assembly 20
0.44109556 | 0.014229362 | 0.64169884 | 0.06109834 | PDR16 | orf19.1027 | Phosphatidylinositol transfer protein; increased transcription correlates with CDR1 and CDR2 overexpression and azole resistance; induced by fluphenazine, 17-beta-estradiol, ethynyl estradiol, nitric oxide; farnesol-downregulated in biofilm
0.43323562 | 0.00500336 | 0.8091057 | 0.1529504 |  | orf19.4964 | Predicted ORF in Assemblies 19, 20 and 21
0.4141365 | 0.035923988 | 0.6051747 | 0.13361093 | PFK1 | orf19.3967 | Alpha subunit of phosphofructokinase (PFK), which is Pfk1p, Pfk2p heteromultimer; PFK is activated by fructose 2,6-bisphosphate or AMP, inhibited by ATP; activity reduced on hyphal induction; phagocytosis-downregulated; fluconazole-induced
0.40076563 | 0.029458238 | 0.36042398 | 0.05848094 | CBP1 | orf19.7323 | Corticosteroid binding protein; transcription induced at late log-phase or upon adherence to polystyrene; not induced by corticosterone; contains a possible NAD/FAD binding region; regulated by Nrg1p, Tup1p
0.39727882 | 0.018767625 | 0.5290698 | 0.0032899862 | HOM32 | orf19.6959 | [NAME] 4-P-transferase; fungal-specific (no human or murine homolog); removed from Assembly 20
WT+CF VS WT | t-test P-value | age3+CF vs age3 | t-test P-value | common name | systematic name | description
7.178476 | 0.08711812 | 10.226856 | 0.0005863729 | PGA23 | orf19.3740 | Putative GPI-anchored protein of unknown function; transcription is negatively regulated by Rim101p; regulated by Cyr1p; shows colony morphology-related gene regulation by Ssn6p
5.2205257 | 0.16325486 | 6.745825 | 0.03892476 |  | orf19.7296 | Predicted ORF in Assemblies 19, 20 and 21; similar to stomatin mechanoreception protein; induced by Rgt1p
3.7449605 | 0.06262431 | 5.1480894 | 0.022659574 | ICL1 | orf19.6844 | Isocitrate lyase; enzyme of glyoxylate cycle; required for wild-type virulence in murine systemic infection; no mammalian homolog; gene induced upon phagocytosis by macrophage; farnesol regulated; Pex5p-dependent peroxisomal localization
4.4277744 | 0.1136623 | 5.024851 | 0.029065173 | [NAME] | orf19.4377 | Predicted GPI-anchor, role in 1,6-beta-D-glucan biosynthesis; production in S. cerevisiae increases glucan content and complements killer toxin sensitivity of [NAME] mutant; possible N-linked glycosylation at Asn109; caspofungin induced
3.3198152 | 0.103131734 | 4.6468964 | 9.8071636e-05 |  | orf19.7504 | Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; induced in core caspofungin response
5.324931 | 0.08816517 | 4.4819894 | 0.010670369 | CSH1 | orf19.4477 | Member of aldo-keto reductase family, similar to aryl alcohol dehydrogenases; role in adhesion to fibronectin, cell surface hydrophobicity; regulated by temperature, growth phase, benomyl, macrophage interaction; azole resistance associated
2.7936876 | 0.054587614 | 4.2508855 | 0.042393617 | LDG3 | orf19.6486 | Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation
1.8109454 | 0.17394671 | 4.1156116 | 0.0438155 |  | orf19.6487 | Predicted ORF in Assemblies 19, 20 and 21
4.77714 | 0.13393976 | 3.9093342 | 0.0004268178 | ECM331 | [NAME] | GPI-anchored protein; mainly at plasma membrane, also at cell wall; caspofungin induced; Plc1p-regulated; repressed by Rim101p, Hog1p; colony morphology-related gene regulation by Ssn6p; induced in cyr1 homozygous null mutant yeast-form cel
2.5872002 | 0.06870198 | 3.3190894 | 0.007858315 | NOG2 | orf19.5732 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
4.276519 | 0.08656753 | 3.275366 | 0.005169157 | PHR1 | orf19.3829 | Glycosidase of cell surface; may act on cell-wall beta-1,3-glucan prior to beta-1,6-glucan linkage; E169 and E270 at active site; role in systemic but not vaginal virulence (neutral, not low pH); high pH or filamentation induced
1.2270132 | 0.04316499 | 3.0838943 | 0.025538042 | RBR1 | orf19.535 | [NAME] (GPI)-anchored cell wall protein required for filamentous growth at acidic pH; expression is repressed by Rim101p and activated by Nrg1p
2.2072341 | 0.11629283 | 3.0764928 | 0.025075046 | DPP3 | orf19.6459 | Protein similar to S. cerevisiae pyrophosphate phosphatase Dpp1p; required for farnesol biosynthesis; downregulated in response to 17-beta-estradiol, ethynyl estradiol
2.3594062 | 0.17742589 | 3.0623198 | 0.04776691 |  | orf19.5070 | Predicted ORF in Assemblies 19, 20 and 21; transcriptionally regulated by iron; expression greater in low iron; similar to cell-wall mannoproteins; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; regulated by osmotic and oxidative stress via Hog1p; possibly spurious ORF (Annotation Working Group prediction)
1.683163 | 0.020614594 | 2.9622347 | 0.022642158 | DIM1 | orf19.5010 | Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Dim1p, which is an 18S rRNA dimethylase involved in rRNA modification and processing; induced upon biofilm formation
1.9354535 | 0.14210872 | 2.9608397 | 0.019370101 | [NAME] | orf19.5500 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
2.2494385 | 0.09188119 | 2.8232374 | 0.0044308566 |  | orf19.2431 | Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
1.7779903 | 0.07733421 | 2.7100403 | 0.03339241 |  | orf19.2167 | Predicted ORF in Assemblies 19, 20 and 21
2.534456 | 0.075085364 | 2.689919 | 0.0021217405 | CZF1 | orf19.3127 | Transcriptional regulator of white-opaque switching frequency; hyphal growth regulator; has C-terminal zinc finger and central [NAME]-rich region; expression in S. cerevisiae causes dominant-negative inhibition of pheromone response
1.7315643 | 0.058007676 | 2.6581054 | 0.002496833 | KRR1 | orf19.661 | Decreased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses [NAME]; induced upon biofilm formation
2.2906225 | 0.13418299 | 2.6332955 | 0.003985739 |  | orf19.192 | Predicted ORF in Assemblies 19, 20 and 21
2.2943451 | 0.104932725 | 2.5847085 | 0.00166528 |  | orf19.2244 | Similar to oxidoreductases and to S. cerevisiae Yjr096wp; transcription is negatively regulated by Sfu1p; increased transcription is observed upon benomyl treatment; decreased expression observed in an ssr1 homozygous null mutant
1.9430412 | 0.05872231 | 2.5721967 | 0.043413736 |  | orf19.1091 | Putative ortholog of S. cerevisiae Nop8p, which is a nucleolar protein required for 60S ribosomal subunit biogenesis
1.6623243 | 0.19937776 | 2.5570436 | 0.033380806 |  | orf19.2734 | Protein not essential for viability
1.3675982 | 0.15730396 | 2.5522456 | 0.0465079 |  | orf19.1146 | Predicted ORF in Assemblies 19, 20 and 21
1.8168745 | 0.13597928 | 2.5095897 | 0.03806551 |  | orf19.3252 | Predicted zinc-finger protein of unknown function; has similarity to S. cerevisiae Dal81p, which is a transcription factor involved in the regulation of nitrogen-degradation genes
2.0314605 | 0.077783845 | 2.4375582 | 0.0009597667 | DFG5 | orf19.2075 | N-linked mannoprotein of cell wall and membrane; possible signal transducer; role in hyphal growth and HWP1 induction in alkaline pH; GPI modification predicted; dfg5 dcw1 double mutant is inviable; caspofungin-induced, fungal-specific
1.600189 | 0.01967619 | 2.4071434 | 0.028410543 |  | orf19.3535 | Predicted ORF in Assemblies 19, 20 and 21
2.0853548 | 0.056625143 | 2.3739424 | 0.009013342 |  | orf19.5876 | Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; transcription is induced in response to alpha pheromone in SpiderM medium
1.6001545 | 0.13541746 | 2.3187988 | 0.026253253 |  | orf19.6236 | Predicted ORF in Assemblies 19, 20 and 21
1.7924125 | 0.13304353 | 2.2818475 | 0.04800539 | RRP15 | orf19.563 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
1.8155482 | 0.03136399 | 2.2751675 | 0.03160799 | FRP2 | orf19.7112 | Protein described as ferric reductase; alkaline upregulated by Rim101p; fluconazole-downregulated; upregulated in the presence of human neutrophils; possibly adherence-induced
1.8743839 | 0.080642626 | 2.234045 | 0.0072081713 | PCL1 | orf19.2649 | Cyclin homolog; expression induced upon filamentous growth; transcription is induced in response to alpha pheromone in SpiderM medium
1.8071615 | 0.09917392 | 2.1902544 | 0.0070808004 |  | orf19.5905 | Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation
1.6556586 | 0.020744557 | 2.1850944 | 0.00026099314 |  | orf19.6992 | Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS)
1.7010177 | 0.043013375 | 2.1759307 | 0.011196898 | [NAME] | orf19.5867 | Protein described as a cell wall component; increased mRNA abundance observed in cyr1 homozygous null mutant (yeast-form or hyphal cells)
2.0729904 | 0.05336355 | 2.1741154 | 0.009094706 |  | orf19.270 | Predicted ORF in Assemblies 19, 20 and 21
1.2710342 | 0.26293018 | 2.1520634 | 0.034820028 |  | orf19.2330 | Predicted ORF in Assemblies 19, 20 and 21; transposon mutation affects filamentous growth; decreased expression in response to prostaglandins
1.6673793 | 0.006387083 | 2.1355667 | 0.0285177 |  | orf19.7672 | Predicted ORF in Assemblies 19, 20 and 21
1.219551 | 0.069852866 | 2.1326556 | 0.0017421079 | RRN3 | orf19.1923 | Predicted ORF in Assemblies 19, 20 and 21; caspofungin induced, flucytosine repressed; downregulated in core stress response; decreased expression in response to prostaglandins
1.5294594 | 0.000102774786 | 2.1292052 | 0.0031778396 |  | orf19.1404 | Predicted ORF in Assemblies 19, 20 and 21
1.5894716 | 0.058273673 | 2.1190953 | 0.0038525295 | ENP1 | orf19.5507 | Protein similar to S. cerevisiae Enp1p; transposon mutation affects filamentous growth; decreased expression in response to prostaglandins
2.1312504 | 0.063439906 | 2.116114 | 0.0378066 |  | orf19.7084
1.6438124 | 0.0025281466 | 2.0735946 | 0.0051542083 |  | orf19.3826 | Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated
1.7770356 | 0.06541339 | 2.072257 | 0.0019454736 | UAP1 | orf19.4265 | UDP-N-acetylglucosamine pyrophosphorylase, catalyzes biosynthesis of UDP-N-acetylglucosamine from UTP and N-acetylglucosamine 1-phosphate; functional homolog of S. cerevisiae Qri1p; alkaline upregulated
1.8696955 | 0.0980815 | 2.0669441 | 0.0057873297 | RIM101 | orf19.7247 | Transcription factor involved in alkaline pH response; required for alkaline-induced hyphal growth; role in virulence in mouse systemic infection; activated by C-terminal proteolytic cleavage; mediates both positive and negative regulation
1.9452044 | 0.028387677 | 2.0587735 | 0.044640757 |  | orf19.6264 | Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction)
2.076022 | 0.06424507 | 2.0513575 | 0.0040311995 |  | orf19.4900 | Predicted ORF in Assemblies 19, 20 and 21
1.8462824 | 0.016978214 | 2.0347557 | 0.0020682707 | [NAME] | orf19.4890 | S/T kinase of Ste20p family; required for wild-type filamentous growth and for wild-type organ colonization and virulence in mouse systemic infection; role in chlamydospore formation; functional homolog of S. cerevisiae Cla4p
1.8832952 | 0.1358328 | 2.013936 | 0.039207812 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21; hyphal-induced expression, regulated by Cyr1p, Ras1p, Efg1p; possibly spurious ORF (Annotation Working Group prediction)
1.8811563 | 0.008070869 | 2.012281 | 0.00014937605 |  | orf19.6527 | Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p; transcriptionally activated by Mnl1p under weak acid stress
1.6218369 | 0.12794296 | 2.0019295 | 0.0056409454 |  | orf19.5517 | Similar to alcohol dehydrogenases; increased transcription is observed upon benomyl treatment; induced by nitric oxide; induced in core stress response; oxidative stress-induced via Cap1p
0.3559798 | 0.07392754 | 0.49746096 | 0.026363907 | PGA10 | orf19.5674 | Plasma membrane protein involved in heme-iron utilization; allows utilization of hemin and hemoglobin as iron sources in host tissues; predicted GPI anchor; hypoxia, ketoconazole, ciclopirox, or hyphal-induced; upregulated by Rim101p at pH8
0.65289176 | 0.16110957 | 0.49573272 | 0.011235987 | NDE1 | orf19.339 | Putative NADH dehydrogenase that could act alternatively to complex I in respiration; [NAME] repressed; fungal-specific (no human or murine homolog); transcription is upregulated in both intermediate and mature biofilms
0.48926273 | 0.07311399 | 0.4883039 | 0.022705507 |  | orf19.5620 | Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment); increased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses [NAME]
0.6489676 | 0.01241236 | 0.4868682 | 0.018656686 |  | orf19.149 | Predicted ORF in Assemblies 19, 20 and 21
0.5524067 | 0.014179363 | 0.48502615 | 0.008752176 |  | orf19.719 | Predicted ORF in Assemblies 19, 20 and 21
0.5211565 | 0.07457521 | 0.48424459 | 2.2754235e-05 | TPS3 | orf19.5348 | Protein described as regulatory subunit of trehalose-phosphate synthase; regulated by Efg1p; biofilm-repressed expression; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions
0.55113876 | 0.056385078 | 0.48150748 | 0.018801806 | [NAME] | orf19.3554 | Protein described as aspartate aminotransferase; soluble protein in hyphae; macrophage-induced protein; alkaline upregulated; amphotericin B repressed; gene used for strain identification by multilocus sequence typing, farnesol-induced
0.4760511 | 0.08159966 | 0.4808673 | 0.0499243 | AOX2 | orf19.4773 | Alternative oxidase; induced by antimycin A, some oxidants; growth- and carbon-source-regulated; one of two isoforms (Aox1p and Aox2p); involved in cyanide-resistant respiratory pathway that is absent from S. cerevisiae
0.5813506 | 0.03848107 | 0.48033988 | 0.04518981 | MGE1 | orf19.2524 | Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed
0.61014533 | 0.00040329713 | 0.4791938 | 0.009160954 | ADE5,7 | orf19.5061 | Enzyme of adenine biosynthesis; interacts with Vps34p; required for hyphal growth and virulence; flucytosine induced; not induced during GCN response, in contrast to the S. cerevisiae ortholog
0.5265443 | 0.24863715 | 0.47898614 | 0.0005179409 |  | orf19.461 | Protein similar to S. cerevisiae Mhp1p, which is involved in microtubule stabilization; transposon mutation affects filamentous growth; merged with orf19.6621 in Assembly 20
0.50217104 | 0.0006215898 | 0.46653014 | 3.381433e-07 | DES1 | orf19.4048 | Putative delta-4 sphingolipid desaturase
0.48983443 | 0.077410504 | 0.4648914 | 0.032340687 | DAP1 | orf19.489 | Protein similar to S. cerevisiae Dap1p, which is a protein related to mammalian membrane-associated progesterone receptors involved in response to DNA damage; induced in core stress response; Hog1p regulated; clade-associated expression
0.5510601 | 0.11222534 | 0.463088 | 0.00012447672 |  | orf19.1352 | Predicted ORF in Assemblies 19, 20 and 21
0.45558214 | 0.06804055 | 0.46003634 | 0.000754397 |  | orf19.5628 | Predicted ORF in Assemblies 19, 20 and 21
0.5582442 | 0.016034395 | 0.44655192 | 0.044996656 | MIS11 | orf19.2364 | Similar to precursor of mitochondrial C1-tetrahydrofolate synthase; putative protein of glycine catabolism; downregulated by Efg1p; fluconazole-induced; protein detected by mass spec in stationary phase cultures
0.5329354 | 0.005866491 | 0.445297 | 0.04009216 |  | orf19.7325 | Predicted ORF in Assemblies 19, 20 and 21
0.5846122 | 0.025130847 | 0.43935433 | 0.027836733 |  | orf19.5408 | Predicted ORF in Assemblies 19, 20 and 21
0.660447 | 0.11816548 | 0.43914855 | 0.027954567 |  | orf19.921 | Predicted ORF in Assemblies 19, 20 and 21
0.55880016 | 0.096819036 | 0.43643582 | 0.0042609135 | NPR1 | orf19.6232 | Predicted ORF in Assemblies 19, 20 and 21; induced in core stress response
0.6178115 | 0.18939707 | 0.42569807 | 0.01596076 |  | orf19.4581 | Predicted ORF in Assemblies 19, 20 and 21; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions
0.55145437 | 0.0017143058 | 0.42007333 | 1.6840773e-05 |  | orf19.1593 | Protein not essential for viability; similar to S. cerevisiae Rim11p, which is a protein kinase involved in meiosis and sporulation; merged with orf19.791 in Assembly 20
0.5596668 | 0.013049904 | 0.418614 | 0.0005788437 | SHM2 | orf19.5750 | Cytoplasmic serine hydroxymethyltransferase; complements the glycine auxotrophy of an S. cerevisiae shm1 null shm2 null gly1-1 triple mutant; antigenic in human; soluble protein in hyphae; farnesol-upregulated in biofilm
0.5265973 | 0.005660757 | 0.41415262 | 0.007109539 | HRT2 | orf19.4624 | Protein described as having a role in Ty3 transposition; decreased expression in hyphae compared to yeast-form cells; protein detected by mass spec in stationary phase cultures
0.48555195 | 0.059656765 | 0.41300184 | 0.014120996 | STF2 | orf19.2107.1 | Protein involved in ATP biosynthesis; decreased expression in hyphae compared to yeast-form cells; downregulated by Efg1p; transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis
0.42857867 | 0.053251922 | 0.4091151 | 0.049161073 |  | orf19.1788 | Predicted ORF from Assembly 19; merged with orf19.1290 in Assembly 20
0.5392976 | 0.013107595 | 0.40537277 | 1.1683345e-05 |  | orf19.3678 | Protein not essential for viability
0.52885824 | 0.12856762 | 0.40508085 | 0.03912713 | TPS1 | orf19.6640 | Trehalose-6-phosphate synthase; role in hyphal growth and virulence in mouse systemic infection; upregulated in presence of human neutrophils; macrophage/pseudohyphal-repressed after 16h; detected by mass spec in stationary phase cultures
0.34086224 | 0.08202909 | 0.4016507 | 0.024623757 | VTC3 | orf19.4381 | Putative polyphosphate synthetase; downregulated in core caspofungin response; Hog1p-induced; transcription is opaque-specific; fungal-specific (no human or murine homolog)
0.6813601 | 0.048723344 | 0.3972848 | 0.01348807 | ADE6 | orf19.6317 | Enzyme of adenine biosynthesis; not induced during GCN response, in contrast to the S. cerevisiae ortholog; protein detected by mass spec in stationary phase cultures
0.52941835 | 0.13452089 | 0.39068946 | 0.030846713 |  | orf19.4550 | Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS)
0.30107993 | 0.14090459 | 0.38160792 | 0.0095820865 |  | orf19.4907 | Predicted ORF in Assemblies 19, 20 and 21; increased transcription is observed upon fluphenazine treatment; possibly transcriptionally regulated by Tac1p; induced by nitric oxide; fungal-specific (no human or murine homolog)
0.59461683 | 0.11840787 | 0.3669064 | 0.02836888 |  | orf19.1802 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
0.52670765 | 0.025383078 | 0.3651114 | 0.012259108 | ADE13 | orf19.3870 | Enzyme of adenine biosynthesis; soluble protein in hyphae; not induced during GCN response, in contrast to the S. cerevisiae ortholog; repressed by nitric oxide
0.46656835 | 0.14531708 | 0.364035 | 0.0038842978 |  | orf19.3641 | Expression is regulated upon white-opaque switching; merged with orf19.84 in Assembly 20
0.3909906 | 0.071157694 | 0.36099005 | 0.04550101 | [NAME] | orf19.3618 | Protein with suggested role in dispersal in host; mutation causes increased adhesion and biofilm formation; putative GPI-anchor; cell wall and secreted; has stable propeptide; regulated by growth phase, phosphate, Ssk1p, Ssn6p, Efg1p, Efh1p
0.66516596 | 0.001249517 | 0.35407907 | 0.00018464372 | GCV1 | orf19.5519 | Protein described as T subunit of glycine decarboxylase; transcription is negatively regulated by Sfu1p
0.38342348 | 0.13402204 | 0.34877068 | 0.0044039823 | OPT9 | orf19.2584 | Probable pseudogene similar to fragments of OPT1 oligopeptide transporter gene; decreased expression in hyphae compared to yeast-form cells; transcriptionally induced upon phagocytosis by macrophage
0.5862544 | 0.13951291 | 0.3459363 | 0.00084649154 | ERG251 | orf19.4631 | Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-induced; amphotericin B, [NAME] repressed
0.5623348 | 0.117255725 | 0.34286198 | 0.04816914 |  | orf19.1433 | Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p
0.27915823 | 0.055206 | 0.3311585 | 0.019895187 |  | orf19.1314 | Predicted ORF in Assemblies 19, 20 and 21
0.58914167 | 0.0014168501 | 0.3298646 | 0.0010020783 |  | orf19.1306 | Predicted ORF in Assemblies 19, 20 and 21
0.38287294 | 0.10102204 | 0.32866833 | 0.019298812 |  | orf19.915 | Predicted ORF in Assemblies 19, 20 and 21
0.5907703 | 0.00883005 | 0.323695 | 0.00010978178 | [NAME] | orf19.2948 | Protein of unknown function expressed during stationary phase; transcription is regulated by Tup1p, Efg1p
0.39946228 | 0.07567399 | 0.3215935 | 0.0018123008 | VTC4 | orf19.3363 | Protein described as polyphosphate synthetase; decreased expression in hyphae compared to yeast-form cells; fungal-specific (no human or murine homolog); virulence-group-correlated expression
0.5180137 | 0.05545738 | 0.3165508 | 0.041467372 | GPD1 | orf19.1756 | Protein similar to S. cerevisiae glycerol-3-phosphate dehydrogenase (enzyme of glycerol biosynthesis); biofilm-induced expression; regulated by Efg1p; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions
0.5888956 | 0.08390255 | 0.3138566 | 0.033113427 | GAL10 | orf19.3672 | UDP-glucose 4-epimerase, required for galactose utilization; mutant shows cell wall defects and increased filamentation; fluconazole-induced; protein detected by mass spec in stationary phase cultures
0.4114094 | 0.16085583 | 0.30831984 | 0.02861394 | GPM2 | orf19.1067 | Protein described as phosphoglycerate mutase; decreased expression in hyphae compared to yeast-form cells; macrophage/pseudohyphal-repressed; induced by high levels of peroxide stress, farnesol-induced
0.2394259 | 0.110238634 | 0.29028556 | 0.0067090113 | PGA45 | orf19.2451 | Cell wall protein; putative GPI-anchor; downregulated in core caspofungin response; Hog1p-induced; regulated by Ssn6p; Mob2p-dependent hyphal regulation; possibly spurious ORF (Annotation Working Group prediction)
0.38374084 | 0.11211367 | 0.28998893 | 0.046453446 |  | orf19.13 | Putative glucokinase; regulated upon yeast-hyphal switch; regulated by Efg1p; fluconazole-induced; induced in core stress response; shows colony morphology-related gene regulation by Ssn6p; merged with orf19.734 in Assembly 20
0.26337495 | 0.068386026 | 0.2855061 | 0.024451831 |  | orf19.411 | Protein described as similar to GTPase regulators; possibly spurious ORF (Annotation Working Group prediction); transcriptionally regulated by iron; expression greater in low iron; transcriptionally activated by Mnl1p under weak acid stress
0.5860682 | 0.2337279 | 0.28451315 | 0.013563075 |  | orf19.1522 | Predicted ORF in Assemblies 19, 20 and 21
0.46333572 | 0.06437406 | 0.2831269 | 0.041968815 | ZRT2 | orf19.1585 | Protein described as predicted zinc transporter; ciclopirox olamine, fluconazole, or alkaline downregulated; transcriptionally induced by interaction with macrophage; amphotericin B induced
0.34390938 | 0.07398416 | 0.27618423 | 0.024011642 |  | orf19.1034 | Predicted ORF in Assemblies 19, 20 and 21; [NAME] repressed
0.36688262 | 0.07810491 | 0.27192068 | 0.011976172 | GLK1 | [NAME] | Putative glucokinase; transcription is regulated upon yeast-hyphal switch; transcriptionally regulated by Efg1p; fluconazole-induced; induced in core stress response; shows colony morphology-related gene regulation by Ssn6p
0.4293848 | 0.054902036 | 0.2702304 | 0.00012935535 | GAL7 | orf19.3675 | Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed
0.27820563 | 0.053748753 | 0.25246796 | 0.004675149 | UPC2 | orf19.391 | Transcriptional regulator of ergosterol biosynthetic genes and sterol uptake; binds ERG2 promoter; has Zn(2)-Cys(6) binuclear cluster; induced upon ergosterol depletion, by azoles, anaerobicity; macrophage/pseudohyphal-repressed
0.4280886 | 0.06398753 | 0.242905 | 0.005558295 |  | orf19.7104 | Predicted ORF in Assemblies 19, 20 and 21; similar to mucins and to a Litomosoides microfilarial sheath protein
0.3713699 | 0.090128444 | 0.23376276 | 0.03277181 | FTR1 | orf19.7219 | High-affinity iron permease (ferric citrate, ferrioxamines E or B, transferrin); required for mouse virulence, low-iron growth; iron, amphotericin B, caspofungin, ciclopirox, Hog1p regulated; complements S. cerevisiae ftr1 iron transport
0.3866209 | 0.20986752 | 0.19877298 | 0.0027193534 | OPT1 | orf19.2602 | Oligopeptide transporter; transports 3-to-5-residue peptides; alleles are distinct, one has intron; not ABC or PTR type transporter; suppresses S. cerevisiae ptr2-2 mutant defects; induced by BSA or peptides; Stp3p, Hog1p regulated
0.29592723 | 0.09477046 | 0.15564646 | 0.017973823 | ENG1 | orf19.3066 | Endo-1,3-beta-glucanase required for cell separation after division, orthologous to S. cerevisiae Dse4p; [NAME] repressed; fungal-specific (no human or murine homolog); repressed in response to alpha pheromone in SpiderM medium
0.13717963 | 0.061640505 | 0.10090931 | 2.158713e-05 |  | orf19.1691 | Predicted ORF in Assemblies 19, 20 and 21; fluconazole-induced; filament induced; Hog1p-induced; regulated by Nrg1p, Tup1p; increased expression in response to prostaglandins