Spreadsheet: d426921a-d19a-4636-bfec-81aea22cbc0f
Sheet: eGFRcrea vs eGFRcys

Effects of novel and known loci on eGFRcrea and on [NAME]
Origin | SNP ID | Chr | Position | Genes nearby | Reference allele (eGFRcrea lowering allele) | eGFRcrea |  |  | [NAME]
 |  |  |  |  |  | b | SE | P value | b | SE | P value
Novel loci (N = 130,600) | rs3925584 | 11 | 30716911 | MPPED2 | T | -0.0075 | 0.0009 | 8.38e-18 | -0.0061 | 0.002239163080144704 | 0.00558566463992466
 | rs6431731 | 2 | 15780453 | DDX1 | T | -0.0127 | 0.0023 | 4.27e-08 | -0.0067 | 0.006412148820414377 | 0.297516990130804
 | rs12124078 | 1 | 15742486 | CASP9 | G | -0.0091 | 0.001 | 9.49e-22 | -0.0069 | 0.002442723360157858 | 0.00392563827998304
 | rs2453580 | 17 | 19378913 | SLC47A1 | C | -0.0052 | 0.001 | 5.16e-08 | -0.0047 | 0.002544503500164436 | 0.0596491265431046
 | rs11078903 | 17 | 34885450 | CRKRS | A | -0.0067 | 0.0011 | 3.07e-09 | -0.0019 | 0.002646283640171013 | 0.47095967371188
 | rs2928148 | 15 | 39188841 | INO80 | G | -0.0051 | 0.0009 | 4.04e-08 | -0.0028 | 0.002137382940138126 | 0.204138488242408
Known loci possibly related to renal function (N = 74,354) | rs10109414 | 8 | 23807096 | [NAME] | T | -0.0077 | 0.00126003503173385 | 2.07902406825578e-09 | -0.0085 | 0.002239163080144704 | 0.000142414370222939
 | rs11959928 | 5 | 39432889 | DAB2 | A | -0.0093 | 0.00126003503173385 | 5.1926193119622e-13 | -0.008 | 0.002239163080144704 | 0.000403270545362273
 | rs12460876 | 19 | 38048731 | SLC7A9 | T | -0.0085 | 0.00126003503173385 | 8.6259386807881e-11 | -0.0063 | 0.002239163080144704 | 0.00585950757662022
 | rs1260326 | 2 | 27584444 | GCKR | C | -0.0089 | 0.00126003503173385 | 4.48273340230352e-12 | -0.0061 | 0.002239163080144704 | 0.00564768289911306
 | rs12917707 | 16 | 20275191 | UMOD | G | -0.0168 | 0.00168004670897846 | 2.15760221754887e-23 | -0.0189 | 0.002849843920184168 | 3.48286678438654e-11
 | rs13538 | 2 | 73721836 | NAT8 | A | -0.0095 | 0.00157504378966731 | 6.98255846224854e-10 | -0.0101 | 0.002748063780177591 | 0.000223919646740805
 | rs1394125 | 15 | 73946038 | UBE2Q2 | A | -0.0093 | 0.00147004087035615 | 7.4220307929238e-11 | -0.0086 | 0.002544503500164436 | 0.00091402259770913
 | rs17319721 | 4 | 77587871 | SHROOM3 | A | -0.0122 | 0.00126003503173385 | 1.53252736627062e-21 | -0.0143 | 0.002239163080144704 | 1.84115835719293e-10
 | [NAME] | 1 | 109801361 | SYPL2 | A | -0.0071 | 0.001365037951045 | 3.17545986079793e-07 | -0.0053 | 0.002442723360157858 | 0.0293218186889541
 | rs2453533 | 15 | 43428517 | GATM | A | -0.0126 | 0.00126003503173385 | 4.02806320374653e-22 | -0.0015 | 0.002239163080144704 | 0.50604178906847
 | rs267734 | 1 | 149218101 | ANXA9 | T | -0.0093 | 0.00157504378966731 | 3.65650317239677e-09 | -0.0056 | 0.002748063780177591 | 0.0386956543847095
 | rs347685 | 3 | 143289827 | TFDP2 | A | -0.0082 | 0.001365037951045 | 4.95727557020304e-09 | -0.008 | 0.002442723360157858 | 0.00104789305485228
 | rs4744712 | 9 | 70624527 | PIP5K1B | A | -0.0084 | 0.00126003503173385 | 7.67130488653232e-11 | -0.0061 | 0.002239163080144704 | 0.00610932274820726
 | rs626277 | 13 | 71245697 | DACH1 | A | -0.0083 | 0.001365037951045 | 2.85087096876799e-10 | -0.0072 | 0.002340943220151281 | 0.00210081622798523
 | rs6420094 | 5 | 176750242 | SLC34A1 | G | -0.0111 | 0.00147004087035615 | 5.74885092616369e-14 | -0.0092 | 0.002748063780177591 | 0.000884081421808152
 | rs653178 | 12 | 110492139 | ATXN2 | C | -0.0032 | 0.00126003503173385 | 0.0119710837694769 | -0.0128 | 0.002239163080144704 | 1.04668931003381e-08
 | rs7805747 | 7 | 151038734 | PRKAG2 | A | -0.0128 | 0.00178504962828961 | 2.72005504775176e-13 | -0.016 | 0.003765865180243365 | 1.81503401900856e-05
 | rs881858 | 6 | 43914587 | VEGFA | A | -0.0097 | 0.00147004087035615 | 1.60122401422555e-10 | -0.0117 | 0.002646283640171013 | 6.22431266322196e-06
Known loci suspected to be related to creatinine metabolism (N = 74,354) | rs10774021 | 12 | 219559 | SLC6A13 | T | -0.0067 | 0.001365037951045 | 4.66622850114581e-07 | -0.0003 | 0.002340943220151281 | 0.913926118239346
 | rs10794720 | 10 | 1146165 | [NAME] | T | -0.013 | 0.00241506714415654 | 4.95962530126215e-08 | -0.0061 | 0.003867645320249942 | 0.115845604008694
 | rs2279463 | 6 | 160588379 | SLC22A2 | G | -0.0133 | 0.00199505546691192 | 1.10228393864245e-11 | -0.0026 | 0.003358744620217055 | 0.434136960402807
 | rs491567 | 15 | 51733885 | WDR72 | A | -0.0101 | 0.00157504378966731 | 3.54320854338966e-11 | -0.0051 | 0.002748063780177591 | 0.0602354382919638
 | rs6465825 | 7 | 77254375 | TMEM60 | C | -0.0072 | 0.00126003503173385 | 2.04598546637526e-08 | 0.0003 | 0.002239163080144704 | 0.880903839764514
 | rs7422339 | 2 | 211248752 | CPS1 | A | -0.0095 | 0.00147004087035615 | 1.34777679232402e-10 | 0.0036 | 0.002748063780177591 | 0.184999071089363
 | rs9895661 | 17 | 56811371 | [NAME] | C | -0.0095 | 0.00178504962828961 | 4.85013178202804e-08 | -0.0038 | 0.003053404200197323 | 0.212932623853702