Spreadsheet: 2c36e4b0-6fc4-4546-b04e-8daaf0659356
Sheet: Sheet1

Supplementary Figure 3: Amino acid sites surrounding the serine active site (bold and underlined) of the catalytic triad for the serine proteases discovered in the spermathecae. Residues in bold represent the sites involved in substrate specificity. Residues in italics represent sites predicted to be under positive selection by PAML analysis. | Unnamed: 1 | Unnamed: 2
CG3066 | sim | FYRDSCDGDSGGPLMRRGFNQAWYQEGVVSFGNRCGLEGWPGVYTR
 | [NAME] | FYRDSCDGDSGGPLMRRGFDQAWYQEGVVSFGNRCGLEGWPGVYTR
 | sec | FYRDSCDGDSGGPLMRRGFNQAWYQEGVVSFGNRCGLEGWPGVYTR
 | [NAME] | FYRDSCDGDSGGPLMRRGFDQAWYQEGVVSFGNRCGLEGWPGVYTR
 | ere | FYRDSCDGDSGGPLMRRGFDQAWYQEGVVSFGNRCGLEGWPGVYTR
 | ana | FYKDSCDGDSGGPLMREGFNHAWYQEGVVSFGNRCGLEGWPGVYTR
 | pse | FYRDSCDGDSGGPLMRRGFEQAWFQEGVVSFGNRCGLEGWPGVYTS
CG10469 | sim | KKGLPCRGDSGGPMVLDDGTRTLVGIVSHGFDGECKLKLPDISTRV
 | [NAME] | KKGLPCRGDSGGPMVLDDGSRTLVGIVSHGFDGECKLKLPDVSTRV
 | sec | KKGLPCRGDSGGPMVLDDGTRTLVGIVSHGFDGECKLKLPDISTRV
 | [NAME] | KKGLPCRGDSGGPMVLDDGSKTLVGIVSHGFDGECKLKVPDISTRV
 | ere | KEGLPCRGDSGGPMVLDDSTRTLVGIVSHGFDGECKLKLPDISTRV
 | ana | KYGMPCQGDSGSPMVLADGSKTLVGIVSHGLDPACKRKVPDISMRV
 | pse | RAGLPCRGDSGGPLVLDDGSRTLVGIVSHGYDAKCQVKLPDVLTRV
etaTry | sim | GGKDACQGDSGGPLVVANKLAGIVSWGEGCARPNYPGVYANVAYFK
 | [NAME] | GGKDACQGDSGGPLVVANKLAGIVSWGEGCARPNYPGVYANVAYYK
 | sec | GGKDACQGDSGGPLVVANKLAGIVSWGEGCARPNYPGVYANVAYFK
 | [NAME] | GGKDACQGDSGGPLVVANKLSGIVSWGEGCAQPNYPGVYANVAYFK
 | ere | GGKDACQGDSGGPLVVANKLAGIVSWGEGCARPNYPGVYANVAYFK
 | ana | GGKDACQGDSGGPLVVGNKLAGIVSWGEGCARPNYPGVYANVAYFK
 | pse | GGKDACQGDSGGPLVVNNQLVGIVSWGEGCARPNTPGVYANVAHFK
CG17012 | sim | LGKAGCDGDSGGPLVFNDQLVGITSRKGNLLCLASSLYASVAYYRN
 | [NAME] | MGKGGCYGDSGGPLVFNGQLVGITSRTGNIVCLGSSLYASVARYRN
 | sec | IGKGGCDGDSGGPLVFNDQLVGITSRKGNLLCLSSTLYASVAYYRT
 | ana | VGHAHCFGDSGGPLVVEKTLVGISSRTGNAFCLSPGYYVSVAKFRP
CG17234 | sim | YRRTACHGDSGGPLVVNKQLVGVVSWGRKGCQSSTFFVSVPYFREW
 | [NAME] | YGRTACHGDSGGPLVVNKQLVGVVSWGRKGCVSSAFFVSVPYFREW
 | sec | YRRTACHGDSGGPLVVNKQLVGVVSWGRKGCQSSTFFVSVPYFREW
 | [NAME] | YGKTVCEGDSGGPLVVNKQLVGVVSWGKRDCSSRAFFASVPYYREW
 | ere | TGRAACRGDSGGPLVANKQLVGVVSGGSEYCEKSSYYSSVPYFHEW
 | pse | SHKSTLFEDSGGPLTVNKQLVGVVCGGRYG--SPIMYSSVIYHKDW
CG17239 | sim | PGKDACSGDSGGPLVSGDKLVGIVSFGKECAHSKFPGVYANVAELK
 | [NAME] | PGKDACSGDSGGPLVSGNKLVGIVSFGKECAHPEYPGVYANVAELK
 | sec | PGKDACSGDSGGPLVSGNKLVGIVSFGKECAHSKFPGVYANVAELK
 | [NAME] | PGKDACSGDSGGPLVSDGKLVGIVSFGAKCALPKYPGVYANVAVLK
 | ere | PGKDACTGDSGGPLVSGGQLVGIVSFGAECALPQFPGVYANVAELK
 | ana | PGKDACQGDSGGPLVSGGKLVGIVSFGNGCAHPRYPGVYSNVAVLR
Ser12 | sim | LGRDACRGDSGGPLVSGGQLVGIVSYGIGCANPFFPGVYANVAVLK
 | [NAME] | LLKDSCHGDSGGPLVSGGQLVGIVSYGIGCANPFFPGVYANVAELK
 | [NAME] | LLKDSCQGDSGGPLVSGGQLVGIVSHGMLCAIPFYPGVYTNVAVLK
 | ere | LGKDSCQGDSGGPLVSGGQLVGIVSFGYGCANPFFPGVYANVAHLK
CG18125 | sim | YGRTACNGDSGGPLVVGQQLVGVVSGGSEDCTYSALYTSVPYFREW
 | [NAME] | FGRAACKGDSGGPLVFDQQLVGVVSGGTKDCTYSSIYTSVPYFREW
 | sec | YGRTACNGDSGGPLVVGQQLVGVVSGGSEDCTYSALYTSVPYFREW
CG30371 | sim | TGRDSCQFDSGGPVILRKSRQFLVGIISYGKSCAESQYPMGVNTRI
 | [NAME] | TGRDSCQFDSGGPVILRKSRQFLVGIISYGKSCAESQYPMGVNTRI
 | sec | TGRDSCQFDSGGPVILRKSRQFLVGIISYGKSCAESQYPMGVNTRI
 | [NAME] | TGRDSCQFDSGGPVILRKSRQFLVGIISYGMSCAATQYPMGVNTRI
 | ere | TGRDSCQFDSGGPVILRKSRQFLVGIISYGKSCAETQYPMGVNTRI
 | ana | TSRDSCQYDSGGPVILRKSKQFLLGVISFGKSCAETSYPMGVNTRV
 | pse | NARDSCQYDSGGPVILRSSKQFLLGIISFGKSCAANAYPMGVNTRI
CG31681 | sim | HRWDSCEGDSGGPLIEITTGG-HELVGIVSWGEGCGTNLGVYEDIA
 | [NAME] | QRWDTCQGDSGGPLIETTKGGHRQLIGMVSWGDGCGTNPGVYEDIA
 | [NAME] | HRGDTCEGDSGGPLVDTKN---KKLVGIVSWGVGCGINPGVYADVA
 | ere | PGRSACRGDSGGPLVEMET---RKLIGIVSWGFRCGTAPGVYADVA
CG32834 | sim | ~-----------APLVKDGQLVGILSEGGCTTKPDVFANVPWFTGWI
 | [NAME] | NGAGGCSYDTGAPLVIDGQLVGILSEGGCTTKPDVYANVPWFTGWI
 | sec | YGAGGCSYDTGAPLVKDGQLVGILSEGGCTTKPDVFANVPWFTGWI
 | [NAME] | YGAGGCSYDTGAPLVQDDVLVGILSEGGCKTKPDVYASVGWFKDWI
 | ere | YGAGGCSYDTGAALVKDGELVGILSEGGCSTKPDVYASVAWFKGWI
 | ana | SGVGACSYDTGAPLVKDDKLVGILSEGGCTTYPDVYANVAGFKSWI
 | pse | RGTGACYLDEGAPLVVNGFLVGNLGTVGCAGKPDVYANLAQHKSWL