Spreadsheet: 2f87e50d-3fe3-4f2b-85da-3ac8f9e1f57a
Sheet: Sheet1

Table S4. Multinomial logistic regression of methylation class membership (Class 3 is referent) by patient demographic and tumor characteristics. | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8
 | Class 1 | Class 2 | Class 4 | Class 5 | Class 6 | Class 7 | Class 8
 | n = 59 | n = 33 | n = 12 | n = 5 | n = 4 | n = 3 | n = 5 | Overall
Covariate | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | Wald P
Age (per year) | 1.02 (1.02 - 1.02) | 0.97 (0.97 - 0.98) | 1.00 (1.00 - 1.00) | 0.98 (0.97 - 0.99) | 0.99 (0.98 - 0.99) | 0.98 (0.97 - 0.99) | 0.94 (0.93 - 0.95) | < 0.0001
Race |  |  |  |  |  |  |  | 0.65
Caucasian | Referent (Ref) | Ref | Ref | Ref | Ref | Ref | Ref
Hispanic | 1.00 (0.97 - 1.03) | 0.99 (0.97 - 1.00) | 1.00 (0.99 - 1.00) | 1.00 (0.99 - 1.00) | 1.01 (0.98 - 1.03) | 1.00 (0.99 - 1.00) | 1.00 (0.99 - 1.02)
African American | 0.97 (0.94 - 1.00) | 1.03 (0.99 - 1.06) | 1.01 (0.98 - 1.04) | 1.00 (0.99 - 1.00) | 1.00 (0.99 - 1.00) | 1.01 (0.98 - 1.03) | 0.99 (0.99 - 1.00)
Asian | 0.99 (0.96 - 1.03) | 1.00 (0.97 - 1.04) | 1.03 (0.99 - 1.07) | 1.00 (0.99 - 1.00) | 1.00 (0.99 - 1.00) | 1.00 (0.99 - 1.00) | 1.00 (0.99 - 1.00)
Other | 1.00 (0.96 - 1.03) | 0.98 (0.96 - 1.00) | 1.00 (0.98 - 1.02) | 1.01 (0.98 - 1.04) | 1.00 (0.99 - 1.00) | 1.01 (0.99 - 1.03) | 1.00 (0.98 - 1.03)
Alcohol (per g/day) | 0.99 (0.99 - 1.00) | 0.98 (0.97 - 0.99) | 0.92 (0.91 - 0.93) | 0.98 (0.96 - 0.99) | 0.99 (0.97 - 1.01) | 0.99 (0.97 - 1.01) | 1.01 (1.00 - 1.03) | < 0.0001
Total dietary folate | 0.99 (0.99 - 1.00) | 1.03 (1.02 - 1.04) | 0.97 (0.97 - 0.98) | 1.05 (1.02 - 1.07) | 1.10 (1.07 - 1.13) | 0.97 (0.96 - 0.98) | 1.04 (1.03 - 1.05) | < 0.0001
Node status |  |  |  |  |  |  |  | 0.75
Negative | Ref | Ref | Ref | Ref | Ref | Ref | Ref
Positive | 1.00 (0.95 - 1.05) | 1.01 (0.96 - 1.06) | 0.99 (0.96 - 1.02) | 0.99 (0.97 - 1.01) | 0.99 (0.97 - 1.01) | 1.00 (0.99 - 1.02) | 1.00 (0.98 - 1.01)
[NAME] (per mm) | 0.97 (0.96 - 0.98) | 1.01 (1.00 - 1.02) | 1.00 (0.99 - 1.01) | 0.95 (0.94 - 0.96) | 0.97 (0.96 - 0.98) | 0.91 (0.89 - 0.94) | 0.93 (0.93 - 0.94) | < 0.0001
Tumor grade |  |  |  |  |  |  |  | 0.59
Well differentiated | Ref | Ref | Ref | Ref | Ref | Ref | Ref
Moderately diff. | 1.03 (0.98 - 1.07) | 1.02 (0.98 - 1.07) | 0.99 (0.96 - 1.03) | 1.00 (0.97 - 1.03) | 0.99 (0.97 - 1.02) | 1.00 (0.97 - 1.02) | 0.99 (0.97 - 1.01)
Poorly diff. | 0.98 (0.94 - 1.01) | 1.00 (0.96 - 1.04) | 1.02 (0.98 - 1.06) | 0.99 (0.98 - 1.00) | 1.00 (0.98 - 1.02) | 1.00 (0.98 - 1.02) | 0.99 (0.98 - 1.00)
Undifferentiated | 1.00 (0.98 - 1.01) | 1.01 (0.99 - 1.03) | 1.00 (1.00 - 1.00) | 1.00 (1.00 - 1.00) | 1.00 (1.00 - 1.00) | 1.00 (1.00 - 1.00) | 1.00 (1.00 - 1.00)
Estrogen receptor |  |  |  |  |  |  |  | 0.67
Positive | Ref | Ref | Ref | Ref | Ref | Ref | Ref
Negative | 0.99 (0.95 - 1.03) | 1.00 (0.96 - 1.03) | 1.01 (0.98 - 1.05) | 1.00 (0.98 - 1.03) | 1.00 (0.99 - 1.00) | 1.01 (0.98 - 1.03) | 0.99 (0.98 - 1.00)
Histology |  |  |  |  |  |  |  | 0.96
Lobular | Ref | Ref | Ref | Ref | Ref | Ref | Ref
Ductal | 1.01 (0.96 - 1.05) | 0.99 (0.96 - 1.01) | 0.99 (0.99 - 1.00) | 1.01 (0.98 - 1.03) | 1.01 (0.98 - 1.03) | 1.00 (0.99 - 1.00) | 0.99 (0.98 - 1.00)
Adenocarcinoma | 0.99 (0.95 - 1.04) | 0.99 (0.95 - 1.04) | 1.01 (0.97 - 1.05) | 1 (0.98 - 1.03) | 1.01 (0.98 - 1.03) | 1.01 (0.99 - 1.03) | 1.00 (0.97 - 1.02)
The odds ratio (OR) for each covariate in each class is conditional on membership in the given class compared with class [NAME] (3) n=19. The model is controlled for all covariates listed in the table and restricted to samples with available data for all covariates. Results in bold and italics are considered statistically significant (P < 0.05), results in bold only (P ≤ 0.10). CI, confidence interval.