Spreadsheet: 292e57e4-0673-4d89-a404-4b932d1fbec6
Sheet: Sheet1

Supplementary [NAME]. HEK293 proteins decreased >95% confidencea | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10
Accession | HGNC | Name | 6 hpi |  |  |  | 24hpi
 |  |  | z-score |  |  | L:H ratiob | z-score |  |  | L:H ratiob
 |  |  | Expt 1 | Expt 2 | Expt 3 |  | Expt 1 | Expt 2 | Expt 3
Proteins measured in >1 experiment (at a single time point)
35700 | PRPS2 | unnamed protein product |  | -2.328548116093351 |  | 0.4978161289999999 | 0.4539599129982098 | -2.015831824070342 |  | 0.8033196827587984
7239177 | SHPK | CARKL | -0.3178791617943083 | -4.114422325941716 |  | 0.5083942363424749 | 0.1013646009095964 |  |  | 1.076060813
6063691 | VDAC1 | porin isoform 1 | -2.906269195848494 | -0.8118167594661002 | -2.884873971879769 | 0.5713884852516159 |  | 0.3638756346944375 |  | 1.139474517
16307253 | SNP29 | Synaptosomal-associated protein, 29kDa | -1.687274258289406 | -2.13749774104743 | -2.296015944474197 | 0.5868643056844467 | -0.5317026267104958 |  | -1.068822549124627 | 0.7961730394272628
9295343 | MRRP1 | HNYA |  | -2.671620280189796 | -0.8962810495548311 | 0.6145271915576529 |  |  | 0.9101864512380379 | 1.307613804192302
13112017 | Q9BTT9 | [NAME] protein | -0.2464460727411184 | -2.935235382834015 |  | 0.6190747118241724 | -0.4076988649371353 |  |  | 0.8794983750000002
45501009 | Q6NWZ1 | CKAP4 protein |  | -2.042952768186013 | -1.806114859984893 | 0.6219432444850462 |  | -0.401177560284354 | -0.2895317557654403 | 0.9121831369141383
13938553 | KAD6 | [NAME] polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa | -0.836152352701908 | -2.250203608867872 |  | 0.6282618947751691 | -0.6018692333562872 | 0.03252862956003928 |  | 0.9122867967946061
30354279 | AKTS1 | AKT1S1 protein | -1.03250315170288 | -2.045891521283037 |  | 0.6289914281585506 | -0.02777298370654176 | 0.04119797896327904 |  | 1.02363736541263
4885579 | RCD1 | RCD1 required for cell differentiation1 homolog | -1.457238273373747 |  |  | 0.6357566427962617 | -0.3306166629281295 |  | -2.313339583005047 | 0.6977120302985169
55959177 | VPS45 | vacuolar protein sorting 45A (yeast) | -0.8918555054224081 | -2.112895800297553 |  | 0.636370508081706 | -0.3255496718989401 |  |  | 0.90859767
577315 | AMPM1 | KIAA0094 | -2.2336779841968 |  | -0.9253880592291513 | 0.6466154833846918 | -0.07504798020033208 |  |  | 1.003411328
48145521 | RNF14 | RNF14 | 0.04000175425421628 | -2.356904312993946 |  | 0.709484320779474
48146107 | [NAME] | VAMP5 |  | -0.5331643697673147 | -2.825691672900058 | 0.7155851072099123 | 1.223495435627653 |  |  | 1.678563567
7741063 | NUDT4 | diphosphoinositol polyphosphate phosphohydrolase type 2 beta | 0.03832220934602416 | -2.011999923008473 |  | 0.7488847839794807 | -0.2705856768215656 |  |  | 0.9286029379999999
6537210 | PPP6 | serine/threonine protein phosphatase catalytic subunit | 0.6682983208763571 | -2.637048065354865 |  | 0.7496901542485348 | -0.2872437541583612 | -0.5638505125285215 |  | 0.8803771496569158
55957551 | Q5TB52 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.3909601600036791 |  | -2.37694461544092 | 0.752948651731145 | 0.2328950197023832 |  | -1.413197756680283 | 0.8833707769237091
57997480 | BAG6 | hypothetical protein |  | -0.3709930983018437 | -2.503812609991936 | 0.757040277892616 | -0.4204085844558661 |  |  | 0.8750802850000001
31542862 | GRWD1 | glutamate-rich WD repeat containing 1 | -0.8847863257570165 |  |  | 0.7617715734726572 | -0.7285845338020296 | -2.22550165993461 |  | 0.6140251890355519
50949588 | LS14A | hypothetical protein | 0.3385522183822795 |  | -3.152203799149766 | 0.7845318130875889 | -0.1246075412064634 | -0.2626727754458671 | -1.592653407136539 | 0.842413354036149
14041989 | UBP47 | unnamed protein product | -2.233484234145296 | 0.5683326246139867 |  | 0.7853197884422491 | -0.7990152887502887 |  |  | 0.75317461
51258951 | [NAME] | [NAME] protein | 0.4713713746319511 | -2.07067110149608 |  | 0.7945244775030249
5542014 | DKC1 | dyskerin | 0.6761118397831128 | -2.222976050619453 |  | 0.801189843212679 | -0.05796311816036109 |  |  | 1.010227146
27769298 | TRI25 | Tripartite motif-containing 25 | -0.2388274986663169 |  | -1.964549184978193 | 0.8022816522663911 | -0.08638008137530093 | -0.7554917677720805 | 4.59858022093308 | 1.418436166630715
51476912 | Q68D08 | hypothetical protein | -0.6940585532588256 |  |  | 0.8090780701914208 | -0.05591228364002273 | -2.428009639810567 |  | 0.6786119159623673
47605963 | ROCK2 | Rho-associated protein kinase 2 (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2) | -0.6883067486221616 |  |  | 0.8105494430090249 | -0.1298659776103628 | -2.438328262749108 |  | 0.6676093770021196
36122 | RPB2 | RNA polymerase II 140 kDa subunit | -0.592350893347228 |  |  | 0.8354944260006079 | -0.582654279319353 | -2.30652786171764 |  | 0.6236824979493548
27503838 | TPPC5 | Trafficking protein particle complex 5 | -1.577682609566317 | 0.4483440628810736 |  | 0.8547221731394458 | -0.2560112820111204 | -3.14133888933261 |  | 0.580136270138785
15559560 | BGLR | Glucuronidase, beta | -0.4700908496215482 |  |  | 0.868392843255705 | 0.01808994794759515 | -2.458997347145343 |  | 0.6851390957025215
56203612 | ARFG3 | OTTHUMP00000028526 | -0.4277619839373774 |  |  | 0.8800822693864764 | -0.08279421179827863 | -2.229188703898301 |  | 0.6974103376494365
50415798 | Q6DC98 | LMNB1 protein |  | -0.4829694044165883 |  | 0.890227081 | -1.409611893093832 | -2.356123414436273 |  | 0.5251377562688407
14124914 | GLYC | Serine hydroxymethyltransferase 1 (soluble) | -0.3470612610241486 |  |  | 0.9028061048239935 | -0.02035170226781479 |  | -1.987414039677281 | 0.7760999642842613
4503141 | CTSC | cathepsin C isoform a preproprotein | 0.1502950421685678 | -0.7854959724616013 | -0.04319363230113976 | 0.9475019283157485 | 0.4487900030693352 | -2.335886483679614 |  | 0.7614078185254386
56204970 | A8YXX4 | glutamate-ammonia ligase (glutamine synthase) | -0.139872442366868 |  |  | 0.9638699080708207 | -0.09524175072215364 | -8.219618658846423 |  | 0.2601242737141413
47496673 | Q6ICN0 | GRB2 | 0.08698236378827653 | 0.35456958117695 |  | 1.095464701684643 | 0.6932401017678695 | -2.966071491161115 |  | 0.7206188840942531
55958754 | PHP14 | RP11-216L13.10 | 0.5341512934432859 |  |  | 1.192577920235769 | 0.3012132996998416 | -5.518252708661778 |  | 0.4384839314843245
55960176 | [NAME] | laminin, gamma 1 (formerly LAMB2) | 0.1933651165135044 | 2.401427275130426 | -1.435242537508112 | 1.21705118651857 | -2.450331407396363 | -2.413226281352754 |  | 0.4233065507991958
5679449 |  | OTTHUMP00000016179 |  |  |  |  | -2.212569140305808 | 0.2359638899651902 |  | 0.6855708826495179
34535789 | Q6ZR81 | unnamed protein product |  |  |  |  | 0.1430795580026833 | -2.350895947897547 |  | 0.7148960413897965
Proteins measured in only one experiment (at a single time point)
4507525 | SEC62 | translocation protein 1 |  | -4.967024040738184 |  | 0.216863969 |  | -0.2810752954919497 |  | 0.92195352
32967619 | RM21 | MRPL21 protein |  | -4.808181238832313 |  | 0.227988724
57165424 | CUL4A | cullin 4A isoform 1 | -3.738048795382952 |  |  | 0.3093070409118465 | 0.2341841960672455 |  |  | 1.134208685
55663525 | MINP1 | multiple inositol polyphosphate histidine phosphatase, 1 | -3.469782597458944 |  |  | 0.3366610381553343 | -0.7802069301094371 |  |  | 0.7588086839999999
49065378 | ZFAN6 | [NAME] | -3.454471611734831 |  |  | 0.3382932640016173 |  | -0.5746533804487959 |  | 0.837207566
14714481 | CD027 | Chromosome 4 open reading frame 27 | -3.326594314578418 |  |  | 0.3522383612771041 | -1.131656579185433 |  |  | 0.66016632
51105877 | FKBP9 | FK506 binding protein 9, 63 kDa | -3.0901237971952 |  |  | 0.3795576076703677 | -3.276649648049359 | 1.280555524506895 |  | 0.6591689663373199
55665395 | [NAME] | exportin 4 | -3.070417679835404 |  |  | 0.3819276972729763 | 0.6469570739996953 |  |  | 1.335748377
54696458 | CY1 | cytochrome c-1 |  | -3.070714566121991 |  | 0.3940560659999999 |  | 1.684103907204422 |  | 1.758010835
37674431 | PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -2.961708341468869 |  |  | 0.3952708899001222 | -3.178055597417031 |  |  | 0.293427251
4583149 | CASP8 | caspase 8 | -2.85674743820379 |  |  | 0.408596146239233
22761477 | [NAME] | unnamed protein product |  | -2.947164056297956 |  | 0.40969138 |  | 0.2254046645167831 |  | 1.088812663
8489095 | TR10B | Fas-like protein precusor | -2.799566141233847 |  |  | 0.41604363837123 | -1.722221875358459 |  |  | 0.522427961
6102939 | KCMF1 | hypothetical protein | -2.791186657316329 |  |  | 0.4171463568196301 | -0.4855525783641447 |  |  | 0.85278126
56377671 | Q5R2V8 | chromosome 2 open reading frame 4 short form | -2.737655526112466 |  |  | 0.4242602206987582
56208564 | NDK7 | non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) | -2.629296092951541 |  |  | 0.4390338313130762
55665275 | TMCO1 | putative membrane protein (LOC54499) | -2.579622405316324 |  |  | 0.4459771923374918
51479141 | ATP5J | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6 isoform b precursor |  | -2.549112511822146 |  | 0.464409326 |  | 0.0713951538571307 |  | 1.035107122
57208605 | B1AL37 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | -2.435197698148466 |  |  | 0.4667948607965864
55957523 | TRM1L | chromosome 1 open reading frame 25 | -2.431052803353843 |  |  | 0.467406446741744 | -0.7245551880288487 |  |  | 0.7757273030000001
45827731 | SCRIB | scribble isoform a |  | -2.497835311807092 |  | 0.4719700599999999
54696162 | STX5 | syntaxin 5A | -2.374196426994131 |  |  | 0.4758770298140323
37182260 | CWC27 | SDCCAG10 | -2.309293220086094 |  |  | 0.4857342410785994
44889481 | MYO1B | [NAME] | -2.294094503453207 |  |  | 0.4880719055214652
1800303 | TCPH | HIV-1 Nef interacting protein | -2.283736180749043 |  |  | 0.4896715281283727
12698037 | [NAME] | [NAME] | -2.26002462643677 |  |  | 0.4933530377484124
20380411 | OTUD5 | OTUD5 protein | -2.222471703368261 |  |  | 0.4992403027861883
5902128 | STXBP2 | syntaxin binding protein 2 | -2.20660281292348 |  |  | 0.5017491761518112
5138924 | FKBP7 | FK506-binding protein | -2.189368389364054 |  |  | 0.5044882246422256 | 1.59846373282538 |  |  | 1.947439204
7108333 | APAF | apoptotic protease activating factor isoform a | -2.174894632531137 |  |  | 0.5068000715548994
40555890 | NOB1 | NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) | -2.161093837538492 |  |  | 0.5090142944804571
31657111 | LTN1 | listerin E3 ubiquitin protein ligase 1 | -2.14350525837215 |  |  | 0.5118502625871184 | -0.685567345996822 |  |  | 0.787804158
4589594 | NISCH | KIAA0975 protein | -2.108002302462278 |  |  | 0.5176229572999297 | -1.292078189219218 |  |  | 0.619508602
54696984 | SNW1 | SKI-interacting protein | -2.090804670432665 |  |  | 0.5204426121265348 | -0.102314961746845 |  |  | 0.992628598
4505779 | PHKA1 | phosphorylase kinase, alpha 1 (muscle) | -2.070363715176574 |  |  | 0.5238140137686452 | -0.7743193317984765 |  |  | 0.76058097
12804933 | T2AG | General transcription factor IIA, 2, 12kDa | -2.052496466719146 |  |  | 0.5267788078063497 | -2.083862048702865 |  |  | 0.4526826569999999
6005990 | ARSA | arylsulfatase A precursor | -2.003066323947892 |  |  | 0.5350686978125561 | -1.531586991031175 |  |  | 0.563419226
54673708 | Q5U5Z3 | Paraneoplastic antigen MA2 | -2.001569719552051 |  |  | 0.5353217166147568 | -1.369550875881178 |  |  | 0.600780069
6468766 | LCAP | oxytocinase/insulin-responsive aminopeptidase, variant 1 |  | -2.086794763861303 |  | 0.537198939
54611158 | DHX30 | DEAH (Asp-Glu-Ala-His) box polypeptide 30 |  | -2.064637801226129 |  | 0.540960679 |  | -0.2361101163743653 |  | 0.935670302
31563330 | [NAME] | A-kinase anchor protein 13 isoform 1 |  | -2.04542104275811 |  | 0.544244564
37693452 | LS14A | alphaSNBP(A) |  | -2.006516818163494 |  | 0.550953929
55958562 | PTK7 | PTK7 protein tyrosine kinase 7 | -1.687547773863497 |  |  | 0.5911464406654867 | -2.715156333785759 |  |  | 0.352499163
37589006 | TMED9 | Transmembrane emp24 protein transport domain containing 9 |  |  | -2.752435520784931 | 0.5926136917470897
45827739 | A6NIQ6 | vitamin K epoxide reductase complex, subunit 1 isoform 2 |  |  | -2.666602016889475 | 0.6024218502983509
2352904 | DNJA2 | Dnj3/Cpr3 |  |  | -2.161307239100363 | 0.6635425160736622 | 0.4224899350672698 |  |  | 1.222073732
4557701 | [NAME] | keratin 17 |  |  | -1.960091118213602 | 0.6895743067481935 |  | 0.6824335984167127 | -0.9373037569962369 | 0.9965943528269485
16741721 | PLOD1 | Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | -1.133176081354733 |  |  | 0.7042851488976702 | -2.436341264807205 |  |  | 0.393674927
56204070 | LRC41 | MUF1 protein (MUF1) | -1.219898673206052 | -1.108168345331584 |  | 0.7078149381982624 | -2.260074987538367 |  |  | 0.4221535009999999
531122 | [NAME] | beta-adrenergic receptor kinase | -0.8171203344492387 |  |  | 0.778229630006754 |  | -3.887261794913193 |  | 0.282048478
57012964 | SMRC1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 [NAME] subunit) (BRG1-associated factor 155) | -1.050598152055824 |  | -0.1713036939864219 | 0.837749983680012 | -2.074540030988783 |  |  | 0.4543578420000001
33150554 | ARPC5L | [NAME] related protein 2/3 complex, subunit 5-like |  |  | -0.8767022420596352 | 0.8483276273601181 | -2.148548073673082 |  |  | 0.441227339
34594664 | GPSM1 | G-protein signalling modulator 1 (AGS3-like, C. elegans) | -0.4693353837296609 |  |  | 0.8686001037311777 |  | -2.101014524632566 |  | 0.507123211
55660889 | CHK2 | OTTHUMP00000028871 | -0.2700216038427848 |  |  | 0.9250462489129007 | -2.090821045945666 |  |  | 0.451436139
22713625 | PLOD2 | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -1.982857498643933 | 1.67234932690311 |  | 0.9721647804897877 | -2.369603671517889 |  |  | 0.4042241349999999
54673572 | ARP5L | Hypothetical protein LOC90624 |  |  | -0.02814024260325458 | 0.9977971074492463 |  | -2.375393567604191 |  | 0.463421471
20563689 | Q8NHZ6 | mannose phosphate isomerase isoform |  | -0.01361203761956846 |  | 1.032043184 |  | -2.988332577610841 |  | 0.3789193040000001
6969579 | GLSK | glutaminase kidney isoform |  | 0.2017395828843122 |  | 1.104467436 |  |  | -2.26357227364757 | 0.5442792757923369
520587 | KPCD | protein kinase C delta-type |  | 1.009178222717616 |  | 1.424267502 | -1.996226916113541 |  |  | 0.4686779019999999
56206367 | GPAN1 | HLA-B associated transcript 4 |  |  |  |  |  | -9.269261446901075 |  | 0.04815452300000001
55665386 | SRRM1 | serine\/arginine repetitive matrix 1 |  |  |  |  | -6.195373123700214 |  |  | 0.088770323
7023178 | INT9 | unnamed protein product |  |  |  |  | -4.194882352398016 |  |  | 0.196119436
40548403 | DCP1B | decapping enzyme Dcp1b |  |  |  |  | -3.871704695767765 |  |  | 0.222912489
5911846 | TSYL1 | TSPYL |  |  |  |  | -3.739379367444388 |  |  | 0.23491216
7022048 | NOB1 | unnamed protein product |  |  |  |  | -2.941899221126627 |  |  | 0.3222101550000001
20072832 | KISHA | Hypothetical protein MGC23909 |  |  |  |  | -2.84849624491521 |  |  | 0.334358524
4502131 | APBB1 | amyloid beta A4 precursor protein-binding, family B, member 1 isoform E9 |  |  |  |  | -2.657083418748275 |  |  | 0.360704467
9187612 | DUS3L | hypothetical protein, similar to (AF091072.1) predicted protein |  |  |  |  | -2.617450759008936 |  |  | 0.366413676
12052738 | SMG9 | hypothetical protein |  |  |  |  | -2.52730168666116 |  |  | 0.37973874
55958826 | URM1 | RP11-339B21.4 |  |  |  |  | -2.370357068791573 |  |  | 0.404103482
40850975 | ARMC9 | Armadillo repeat containing 9 |  |  |  |  | -2.207637592121586 |  |  | 0.431016645
5138916 | CK054 | PTD012 |  |  |  |  | -2.160007056218028 |  |  | 0.4392284920000001
51094708 | BRAT1 | chromosome 7 open reading frame 27 |  |  |  |  | -2.057297933020655 |  |  | 0.457472635
14279233 | BRE1A | RING finger protein 20 |  |  |  |  | -1.971624495855955 |  |  | 0.473269116
18426915 | DREB | drebrin 1 isoform a |  |  |  |  |  |  | -2.545347993188037 | 0.503530611378404
a Protein is included if at least half of the biologic z-score values are ≤ -1.960σ (indicated by blue bolding) at any time point and there are no major disagreements between biological replicates of the same time point.
b L/H ratio refers to the geometric mean of all log2 L/H values for each given gi number, expressed as relative protein quantity in infected cultures.