Spreadsheet: fd802ad2-80d5-4a6b-8662-4bc30f6d6b5a
Sheet: Sheet1

Average (min+rich) | [NAME] | [NAME] | Reaction ID | Name | [NAME] | [NAME] | EC number
1 | 1 | 1 | EC905 | anthranilate phosphoribosyltransferase | [c]anth + prpp --> ppi + pran | Tyrosine, Tryptophan, and [NAME] | EC-2.4.2.18
1 | 1 | 1 | EC903 | indole-3-glycerol-phosphate synthase | [c]2cpr5p + h --> 3ig3p + co2 + h2o | Tyrosine, Tryptophan, and [NAME] | EC-4.1.1.48
1 | 1 | 1 | EC902 | phosphoribosylanthranilate isomerase (irreversible) | [c]pran --> 2cpr5p | Tyrosine, Tryptophan, and [NAME] | EC-5.3.1.24
1 | 1 | 1 | EC895 | shikimate kinase | [c]atp + skm --> adp + h + skm5p | Tyrosine, Tryptophan, and [NAME] | [NAME]
1 | 1 | 1 | [NAME] | chorismate synthase | [c]3psme --> chor + pi | Tyrosine, Tryptophan, and [NAME] | EC-4.2.3.5
1 | 1 | 1 | EC889 | 3-phosphoshikimate 1-carboxyvinyltransferase | [c]pep + skm5p <==> 3psme + pi | Tyrosine, Tryptophan, and [NAME] | EC-2.5.1.19
1 | 1 | 1 | EC582 | dTMP kinase | [c]atp + dtmp <==> adp + dtdp | Nucleotide Salvage Pathways | EC-2.7.4.9
1 | 1 | 1 | EC569 | nucleoside-diphosphate kinase (ATP:dTDP) | [c]atp + dtdp <==> adp + dttp | Nucleotide Salvage Pathways | EC-2.7.4.6
1 | 1 | 1 | EC547 | [NAME] (GMP:ATP) | [c]atp + gmp <==> adp + gdp | Nucleotide Salvage Pathways | EC-2.7.4.8
1 | 1 | 1 | EC504 | Phosphatidylserine syntase (Ecoli) | [c](0.02) cdpdag1 + ser-L <==> cmp + h + (0.02) ps_EC | Membrane Lipid Metabolism | EC-2.7.8.8
1 | 1 | 1 | [NAME] | Phosphatidic acid synthase (Ecoli) | [c]glyc3p + (0.14) hdeACP + (0.04) myrsACP + octeACP + (0.72) palmACP + (0.1) tdeACP --> (2) ACP + (0.02) pa_EC | Membrane Lipid Metabolism
1 | 1 | 1 | EC501 | Phosphatidylglycerol synthase (Ecoli) | [c](0.02) cdpdag1 + glyc3p <==> cmp + h + (0.02) pgp_EC | Membrane Lipid Metabolism | EC-2.7.8.5
1 | 1 | 1 | EC500 | Phosphatidylglycerol phosphate phosphatase (Ecoli) | [c]h2o + (0.02) pgp_EC --> (0.02) pg_EC + pi | Membrane Lipid Metabolism | [NAME]
1 | 1 | 1 | EC496 | Fatty acid biosynthesis (n-C16:1) | [c]actACP + (19) h + (6) malACP + (13) nadph --> (6) ACP + (6) co2 + (7) h2o + hdeACP + (13) nadp | Membrane Lipid Metabolism
1 | 1 | 1 | EC493 | Fatty acid biosynthesis (n-C14:1) | [c]actACP + (16) h + (5) malACP + (11) nadph --> (5) ACP + (5) co2 + (6) h2o + (11) [NAME] | Membrane Lipid Metabolism
1 | 1 | 1 | [NAME] | Fatty acid biosynthesis (n-C18:1) | [c]actACP + (22) h + (7) malACP + (15) nadph --> (7) ACP + (7) co2 + (8) h2o + (15) [NAME] | Membrane Lipid Metabolism
1 | 1 | 1 | EC489 | Malonyl-CoA-ACP transacylase | [c]ACP + malcoa <==> coa + malACP | Membrane Lipid Metabolism | EC-2.3.1.39
1 | 1 | 1 | EC486 | Fatty acid biosynthesis (n-C12:0) | [c]actACP + (14) h + (4) malACP + (10) nadph --> (4) ACP + (4) co2 + ddcaACP + (5) h2o + (10) nadp | Membrane Lipid Metabolism
1 | 1 | 1 | EC485 | Fatty acid biosynthesis (n-C14:0) | [c]actACP + (17) h + (5) malACP + (12) nadph --> (5) ACP + (5) co2 + (6) h2o + myrsACP + (12) nadp | Membrane Lipid Metabolism
1 | 1 | 1 | EC484 | [NAME] (E.coli) | [c](0.04) pg_EC <==> (0.02) clpn_EC + glyc | Membrane Lipid Metabolism
1 | 1 | 1 | EC483 | CDP-Diacylglycerol synthetase (Ecoli) | [c]ctp + h + (0.02) pa_EC <==> (0.02) [NAME] | Membrane Lipid Metabolism | EC-2.7.7.41
1 | 1 | 1 | EC455 | glucose-1-phosphate adenylyltransferase | [c]atp + g1p + h --> adpglc + ppi | Glycolysis/Gluconeogenesis | EC-2.7.7.27
1 | 1 | 1 | EC454 | glycogen synthase (ADPGlc) | [c]adpglc --> adp + glycogen + h | Glycolysis/Gluconeogenesis | EC-2.4.1.21
1 | 1 | 1 | EC419 | NAD kinase | [c]atp + nad --> adp + h + nadp | Cofactor and Prosthetic Group Biosynthesis | EC-2.7.1.23
1 | 1 | 1 | EC398 | riboflavin synthase | [c](2) dmlz --> 4r5au + ribflv | Cofactor and Prosthetic Group Biosynthesis | EC-2.5.1.9
1 | 1 | 1 | EC397 | FMN adenylyltransferase | [c]atp + fmn + h --> fad + ppi | Cofactor and Prosthetic Group Biosynthesis | EC-2.7.7.2
1 | 1 | 1 | EC395 | riboflavin synthase | [[NAME] --> dmlz + (2) h2o + pi | Cofactor and Prosthetic Group Biosynthesis | EC-2.5.1.9
1 | 1 | 1 | EC394 | diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp) | [c]25drapp + h + h2o --> 5apru + nh4 | Cofactor and Prosthetic Group Biosynthesis | EC-3.5.4.26
1 | 1 | 1 | EC393 | 5-amino-6-(5-phosphoribosylamino)uracil reductase | [c]5apru + h + nadph --> 5aprbu + nadp | Cofactor and Prosthetic Group Biosynthesis | EC-1.1.1.193
1 | 1 | 1 | EC392 | 3,4-Dihydroxy-2-butanone-4-phosphate | [c]ru5p-D --> db4p + for + h | Cofactor and Prosthetic Group Biosynthesis
1 | 1 | 1 | [NAME] | GTP cyclohydrolase II (25drapp) | [c]gtp + (3) h2o --> 25drapp + for + (2) h + ppi | Cofactor and Prosthetic Group Biosynthesis
1 | 1 | 1 | EC326 | dihydrofolate synthase | [c]atp + dhpt + glu-L --> adp + dhf + pi | Cofactor and Prosthetic Group Biosynthesis | EC-6.3.2.12
1 | 1 | 1 | EC325 | dihydroneopterin aldolase | [c]dhnpt --> 6hmhpt + gcald | Cofactor and Prosthetic Group Biosynthesis
1 | 1 | 1 | EC307 | pantothenate kinase | [c]atp + pnto-R --> 4ppan + adp + h | Cofactor and Prosthetic Group Biosynthesis | EC-2.7.1.33
1 | 1 | 1 | EC291 | dephospho-CoA kinase | [c]atp + dpcoa --> adp + coa + h | Cofactor and Prosthetic Group Biosynthesis | EC-2.7.1.24
1 | 1 | 1 | EC290 | phosphopantothenoylcysteine decarboxylase | [c]4ppcys + h --> co2 + pan4p | Cofactor and Prosthetic Group Biosynthesis | EC-4.1.1.36
1 | 1 | 1 | EC285 | pyrimidine phosphatase | [c]5aprbu + h2o --> 4r5au + pi | Cofactor and Prosthetic Group Biosynthesis
1 | 1 | 1 | EC264 | UDP-sugar hydrolase | [c]h2o + u23ga --> (2) h + lipidX + ump | Cell Envelope Biosynthesis
1 | 1 | 1 | EC257 | Lipopolysaccharide synthesis (Ecoli) | [c](3) adphep-L,D + (2) cdpea + (3) ckdo + lipa + (2) udpg --> (3) adp + (2) cdp + (3) cmp + (10) h + lps_EC + (2) udp | Cell Envelope Biosynthesis
1 | 1 | 1 | EC256 | D-glycero-D-manno-heptose 7-phosphate kinase | [c]atp + gmhep7p --> adp + gmhep17bp + h | Cell Envelope Biosynthesis
1 | 1 | 1 | EC255 | D-glycero-D-manno-hepose 1-phosphate adenyltransferase | [c]atp + gmhep1p + h --> adphep-D,D + ppi | Cell Envelope Biosynthesis
1 | 1 | 1 | EC254 | ADP-D-glycero-D-manno-heptose epimerase | [c]adphep-D,D --> adphep-L,D | Cell Envelope Biosynthesis | EC-5.1.3.20
1 | 1 | 1 | EC243 | UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | [c]uacgam + uagmda --> h + uaagmda + udp | Cell Envelope Biosynthesis
1 | 1 | 1 | EC242 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase | [c]alaala + atp + ugmd --> adp + h + pi + ugmda | Cell Envelope Biosynthesis | EC-6.3.2.15
1 | 1 | 1 | EC241 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase | [c]26dap-M + atp + uamag --> adp + h + pi + ugmd | Cell Envelope Biosynthesis | EC-6.3.2.13
1 | 1 | 1 | EC240 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | [c]atp + glu-D + uama --> adp + h + pi + uamag | Cell Envelope Biosynthesis | EC-6.3.2.9
1 | 1 | 1 | EC239 | UDP-N-acetylmuramoyl-L-alanine synthetase | [c]ala-L + atp + uamr --> adp + h + pi + uama | Cell Envelope Biosynthesis | EC-6.3.2.8
1 | 1 | 1 | EC237 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | [c]pep + uacgam --> pi + uaccg | Cell Envelope Biosynthesis | EC-2.5.1.7
1 | 1 | 1 | [NAME] | [NAME] (myristoyl transferase) | [[NAME] --> ACP + lipa | Cell Envelope Biosynthesis
1 | 1 | 1 | EC233 | phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate) | [c]udcpp + ugmda --> uagmda + ump | Cell Envelope Biosynthesis | EC-2.7.8.13
1 | 1 | 1 | [NAME] | [NAME] (lauroyl transferase) | [c]ddcaACP + kdo2lipid4 --> ACP + kdo2lipid4L | Cell Envelope Biosynthesis
1 | 1 | 1 | EC229 | Tetraacyldisaccharide 4'kinase | [c]atp + lipidAds --> adp + h + lipidA | Cell Envelope Biosynthesis | EC-2.7.1.130
1 | 1 | 1 | EC228 | UDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferase | [c]3hmrsACP + u3hga --> ACP + h + u23ga | Cell Envelope Biosynthesis
1 | 1 | 1 | EC227 | UDP-3-O-acetylglucosamine deacetylase | [c]h2o + u3aga --> ac + u3hga | Cell Envelope Biosynthesis
1 | 1 | 1 | EC226 | Lipid A disaccaride synthase | [c]lipidX + u23ga --> h + lipidAds + udp | Cell Envelope Biosynthesis | EC-2.4.1.182
1 | 1 | 1 | EC225 | UDP-N-acetylglucosamine acyltransferase | [c]3hmrsACP + uacgam <==> ACP + u3aga | Cell Envelope Biosynthesis | EC-2.3.1.129
1 | 1 | 1 | EC224 | 3-deoxy-D-manno-octulosonic acid transferase | [c]ckdo + kdolipid4 --> cmp + h + kdo2lipid4 | Cell Envelope Biosynthesis
1 | 1 | 1 | EC223 | 3-deoxy-D-manno-octulosonic acid transferase | [c]ckdo + lipidA --> cmp + h + kdolipid4 | Cell Envelope Biosynthesis
1 | 1 | 1 | EC222 | 3-deoxy-manno-octulosonate cytidylyltransferase | [c]ctp + kdo --> ckdo + ppi | Cell Envelope Biosynthesis | EC-2.7.7.38
1 | 1 | 1 | EC220 | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase | [c]gmhep17bp + h2o --> gmhep1p + pi | Cell Envelope Biosynthesis
1 | 1 | 1 | EC219 | sedoheptulose 7-phosphate isomerase | [c]s7p --> gmhep7p | Cell Envelope Biosynthesis
1 | 1 | 1 | EC210 | glutamine-fructose-6-phosphate transaminase | [c]f6p + gln-L --> gam6p + glu-L | Cell Envelope Biosynthesis | EC-2.6.1.16
1 | 1 | 1 | EC203 | D-alanine-D-alanine ligase (reversible) | [c](2) ala-D + atp <==> adp + alaala + h + pi | Cell Envelope Biosynthesis | EC-6.3.2.4
1 | 1 | 1 | EC193 | undecaprenyl-diphosphatase | [c]h2o + udcpdp --> h + pi + udcpp | Cell Envelope Biosynthesis | EC-3.6.1.27
1 | 1 | 1 | EC192 | Peptidoglycan subunit synthesis | [c]uaagmda --> h + peptido_EC + udcpdp | Cell Envelope Biosynthesis
1 | 1 | 1 | EC188 | spermidine synthase | [c]ametam + ptrc --> 5mta + h + spmd | Arginine and Proline Metabolism | EC-2.5.1.16
1 | 1 | 1 | EC187 | Adenosylmethionine decarboxylase | [c]amet + h <==> ametam + co2 | Arginine and Proline Metabolism | EC-4.1.1.50
0.9965 | 1 | 0.993 | EC327 | GTP cyclohydrolase I | [c]gtp + h2o --> ahdt + for | Cofactor and Prosthetic Group Biosynthesis | EC-3.5.4.16
0.9965 | 0.998 | 0.995 | EC490 | Fatty acid biosynthesis (n-C16:0) | [c]actACP + (20) h + (6) malACP + (14) nadph --> (6) ACP + (6) co2 + (7) h2o + (14) nadp + palmACP | Membrane Lipid Metabolism
0.9865 | 0.983 | 0.99 | EC503 | Phosphatidylserine decarboxylase (Ecoli) | [c]h + (0.02) ps_EC --> co2 + (0.02) pe_EC | Membrane Lipid Metabolism | EC-4.1.1.65
0.9795 | 1 | 0.959 | EC894 | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase | [c]e4p + h2o + pep --> 2dda7p + pi | Tyrosine, Tryptophan, and [NAME] | EC-4.1.2.15
0.9795 | 1 | 0.959 | EC892 | 3-dehydroquinate dehydratase | [c]3dhq <==> 3dhsk + h2o | Tyrosine, Tryptophan, and [NAME] | EC-4.2.1.10
0.9795 | 1 | 0.959 | EC890 | 3-dehydroquinate synthase | [c]2dda7p --> 3dhq + pi | Tyrosine, Tryptophan, and [NAME]
0.969 | 0.98 | 0.958 | EC211 | UDP-N-acetylglucosamine diphosphorylase | [c]acgam1p + h + utp --> ppi + uacgam | Cell Envelope Biosynthesis | EC-2.7.7.23
0.919 | 0.942 | 0.896 | [NAME] | arabinose-5-phosphate isomerase | [c]ru5p-D <==> ara5p | Alternate Carbon Metabolism | EC-5.3.1.13
0.8915 | 0.937 | 0.846 | EC538 | UMP kinase | [c]atp + ump <==> adp + udp | Nucleotide Salvage Pathways
0.8855 | 0.87 | 0.901 | EC428 | [NAME] dehydrogenase | [c]gcald + h2o + nad --> glyclt + (2) h + nadh | Folate Metabolism | EC-1.2.1.21
0.86 | 0.868 | 0.852 | [NAME] | 4-aminobenzoate synthase | [c]4adcho --> 4abz + h + pyr | Cofactor and Prosthetic Group Biosynthesis
0.8505 | 0.89 | 0.811 | EC479 | phosphoribosylpyrophosphate synthetase | [c]atp + r5p <==> amp + h + prpp | Histidine Metabolism | EC-2.7.6.1
0.8475 | 0.849 | 0.846 | EC195 | ethanolamine phosphotransferase | [c]cmp + h + (0.02) pe_EC <==> (0.02) 12dgr_EC + cdpea | Cell Envelope Biosynthesis | EC-2.7.8.1
0.834 | 0.834 | 0.834 | EC204 | Diacylglycerol kinase | [c](0.02) 12dgr_EC + atp --> adp + h + (0.02) pa_EC | Cell Envelope Biosynthesis | EC-2.7.1.107
0.8 | 0.839 | 0.761 | [NAME] | glucosamine-1-phosphate N-acetyltransferase | [c]accoa + gam1p --> acgam1p + coa + h | Cell Envelope Biosynthesis | [NAME]
0.7835 | 0.817 | 0.75 | EC221 | 3-deoxy -D-manno-octulosonic -acid 8-phosphate | [c]ara5p + h2o + pep --> kdo8p + pi | Cell Envelope Biosynthesis | EC-4.1.2.16
0.7835 | 0.817 | 0.75 | EC194 | 3-deoxy-manno-octulosonate-8-phosphatase | [c]h2o + kdo8p --> kdo + pi | Cell Envelope Biosynthesis | EC-3.1.3.45
0.7135 | 0.75 | 0.677 | EC396 | [NAME] | [c]atp + ribflv --> adp + fmn + h | Cofactor and Prosthetic Group Biosynthesis | EC-2.7.1.26
0.697 | 0.458 | 0.936 | EC155 | 5-methylthioribose-1-phosphate isomerase | [c]5mdr1p <==> 5mdru1p | Arginine and Proline Metabolism | EC-5.3.1.23
0.697 | 0.458 | 0.936 | EC149 | 5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase | [c]5mdru1p --> dkmpp + h2o | Arginine and Proline Metabolism
0.6965 | 0.458 | 0.935 | EC512 | methionine adenosyltransferase | [c]atp + h2o + met-L --> amet + pi + ppi | [NAME] | EC-2.5.1.6
0.6755 | 0.826 | 0.525 | EC652 | ribose-5-phosphate isomerase | [c]r5p <==> ru5p-D | Pentose Phosphate Cycle | EC-5.3.1.6
0.6755 | 0.73 | 0.621 | EC575 | ribonucleoside-triphosphate reductase (GTP) | [c]gtp + trdrd --> dgtp + h2o + trdox | Nucleotide Salvage Pathways | EC-1.17.4.2
0.647 | 0.434 | 0.86 | EC158 | 2-keto-4-methylthiobutyrate transamination | [c]2kmb + glu-L --> akg + met-L | Arginine and Proline Metabolism
0.6435 | 0.687 | 0.6 | EC494 | b-ketoacyl synthase | [c]accoa + h + malACP --> actACP + co2 + coa | Membrane Lipid Metabolism
0.642 | 1 | 0.284 | EC371 | nicotinate-nucleotide adenylyltransferase | [c]atp + h + nicrnt --> dnad + ppi | Cofactor and Prosthetic Group Biosynthesis | EC-2.7.7.18
0.637 | 0.706 | 0.568 | EC901 | tryptophan synthase (indoleglycerol phosphate) | [c]3ig3p + ser-L --> g3p + h2o + trp-L | Tyrosine, Tryptophan, and [NAME] | EC-4.2.1.20
0.6295 | 0.717 | 0.542 | EC651 | ribulose 5-phosphate 3-epimerase | [c]ru5p-D <==> xu5p-D | Pentose Phosphate Cycle | EC-5.1.3.1
0.6115 | 0.652 | 0.571 | [NAME] | ribonucleoside-triphosphate reductase (CTP) | [c]ctp + trdrd --> dctp + h2o + trdox | Nucleotide Salvage Pathways | EC-1.17.4.2
0.608 | 1 | 0.216 | EC662 | adenylsuccinate lyase | [c]dcamp <==> amp + fum | Purine and Pyrimidine Biosynthesis | [NAME]
0.608 | 1 | 0.216 | [NAME] | adenylosuccinate synthase | [c]asp-L + gtp + imp --> dcamp + gdp + (2) h + pi | Purine and Pyrimidine Biosynthesis | [NAME]
0.604 | 0.584 | 0.624 | R04620 | 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) | 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate + 3 H2O <=> 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- dihydropteridine + 3 Orthophosphate | Folate biosynthesis | 3.1.3.1
0.599 | 0.604 | 0.594 | EC574 | ribonucleoside-triphosphate reductase (ATP) | [c]atp + trdrd --> datp + h2o + trdox | Nucleotide Salvage Pathways | EC-1.17.4.2
0.5965 | 0.561 | 0.632 | [NAME] | 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine:4- aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase | 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 4-Aminobenzoate <=> Dihydropteroate + H2O | Folate biosynthesis | 2.5.1.15
0.583 | 0.974 | 0.192 | EC657 | GMP synthase | [c]atp + gln-L + h2o + xmp --> amp + glu-L + gmp + (2) h + ppi | Purine and Pyrimidine Biosynthesis | EC-6.3.5.2
0.564 | 0.6 | 0.528 | EC581 | thymidylate synthase | [c]dump + mlthf --> dhf + dtmp | Nucleotide Salvage Pathways | EC-2.1.1.45
0.5565 | 0.492 | 0.621 | R07307 | dCTP aminohydrolase (dUMP-forming) | dCTP + 2 H2O <=> dUMP + Pyrophosphate + NH3 |  | 3.5.4.30
0.555 | 0.533 | 0.577 | EC654 | transketolase | [c]r5p + xu5p-D <==> [NAME] | Pentose Phosphate Cycle | EC-2.2.1.1
0.55 | 0.537 | 0.563 | EC653 | transaldolase | [c]g3p + s7p <==> e4p + f6p | Pentose Phosphate Cycle | EC-2.2.1.2
0.531 | 0.996 | 0.066 | EC365 | quinolinate synthase | [c]dhap + iasp --> h + (2) h2o + pi + quln | Cofactor and Prosthetic Group Biosynthesis
0.5305 | 0.564 | 0.497 | EC904 | anthranilate synthase | [c]chor + gln-L --> anth + glu-L + h + pyr | Tyrosine, Tryptophan, and [NAME] | [NAME]
0.522 | 1 | 0.044 | EC897 | chorismate mutase | [c]chor --> pphn | Tyrosine, Tryptophan, and [NAME] | EC-5.4.99.5
0.5175 | 0.967 | 0.068 | EC658 | IMP dehydrogenase | [c]h2o + imp + nad --> h + nadh + xmp | Purine and Pyrimidine Biosynthesis | EC-1.1.1.205
0.511 | 1 | 0.022 | EC679 | orotidine-5'-phosphate decarboxylase | [c]h + orot5p --> co2 + ump | Purine and Pyrimidine Biosynthesis | EC-4.1.1.23
0.511 | 1 | 0.022 | EC678 | orotate phosphoribosyltransferase | [c]orot5p + ppi <==> orot + prpp | Purine and Pyrimidine Biosynthesis | EC-2.4.2.10
0.511 | 1 | 0.022 | EC675 | dihydroorotase | [c]dhor-S + h2o <==> cbasp + h | Purine and Pyrimidine Biosynthesis | EC-3.5.2.3
0.511 | 1 | 0.022 | EC674 | aspartate carbamoyltransferase | [c]asp-L + cbp --> cbasp + h + pi | Purine and Pyrimidine Biosynthesis | EC-2.1.3.2
0.5085 | 0.587 | 0.43 | EC308 | pantetheine-phosphate adenylyltransferase | [c]atp + h + pan4p --> dpcoa + ppi | Cofactor and Prosthetic Group Biosynthesis | EC-2.7.7.3
0.5005 | 1 | 0.001 | [NAME] | phosphoribosylaminoimidazole synthase | [c]atp + fpram --> adp + air + (2) h + pi | Purine and Pyrimidine Biosynthesis | EC-6.3.3.1
0.5005 | 1 | 0.001 | EC670 | phosphoribosylformylglycinamidine synthase | [c]atp + fgam + gln-L + h2o --> adp + fpram + glu-L + h + pi | Purine and Pyrimidine Biosynthesis | EC-6.3.5.3
0.5005 | 1 | 0.001 | EC668 | IMP cyclohydrolase | [c]h2o + imp <==> fprica | Purine and Pyrimidine Biosynthesis | EC-3.5.4.10
0.5005 | 1 | 0.001 | [NAME] | phosphoribosylglycinamide synthase | [c]atp + gly + pram <==> adp + gar + h + pi | Purine and Pyrimidine Biosynthesis | EC-6.3.4.13
0.5005 | 1 | 0.001 | EC663 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | [c]5aizc + asp-L + atp <==> 25aics + adp + h + pi | Purine and Pyrimidine Biosynthesis | EC-6.3.2.6
0.5005 | 1 | 0.001 | EC661 | adenylosuccinate lyase | [c]25aics <==> aicar + fum | Purine and Pyrimidine Biosynthesis | [NAME]
0.5 | 1 | 0 | EC932 | 2-isopropylmalate hydratase | [c]2ippm + h2o <==> 3c3hmp | [NAME], leucine, and isoleucine metabolism | EC-4.2.1.33
0.5 | 1 | 0 | EC931 | 3-isopropylmalate dehydratase | [c]3c2hmp <==> 2ippm + h2o | [NAME], leucine, and isoleucine metabolism | EC-4.2.1.33
0.5 | 1 | 0 | EC930 | 2-Oxo-4-methyl-3-carboxypentanoate decarboxylation | [c]3c4mop + h --> 4mop + co2 | [NAME], leucine, and isoleucine metabolism
0.5 | 1 | 0 | EC929 | 3-isopropylmalate dehydrogenase | [c]3c2hmp + nad --> 3c4mop + h + nadh | [NAME], leucine, and isoleucine metabolism | EC-1.1.1.85
0.5 | 1 | 0 | EC928 | 2-isopropylmalate synthase | [c]3mob + accoa + h2o --> 3c3hmp + coa + h | [NAME], leucine, and isoleucine metabolism | EC-4.1.3.12
0.5 | 1 | 0 | EC923 | Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) | [c]23dhmp --> 3mop + h2o | [NAME], leucine, and isoleucine metabolism
0.5 | 1 | 0 | EC720 | diaminopimelate decarboxylase | [c]26dap-M + h --> co2 + lys-L | Threonine and Lysine Metabolism | EC-4.1.1.20
0.5 | 1 | 0 | EC713 | dihydrodipicolinate synthase | [c]aspsa + pyr --> 23dhdp + h + (2) h2o | Threonine and Lysine Metabolism | EC-4.2.1.52
0.5 | 1 | 0 | EC478 | phosphoribosyl-AMP cyclohydrolase | [c]h2o + prbamp --> prfp | Histidine Metabolism | EC-3.5.4.19
0.5 | 1 | 0 | EC477 | phosphoribosyl-ATP pyrophosphatase | [c]h2o + prbatp --> h + ppi + prbamp | Histidine Metabolism | EC-3.6.1.31
0.5 | 1 | 0 | EC476 | ATP phosphoribosyltransferase | [c]atp + prpp --> ppi + prbatp | Histidine Metabolism | EC-2.4.2.17
0.5 | 1 | 0 | EC475 | Imidazole-glycerol-3-phosphate synthase | [c]gln-L + prlp --> aicar + eig3p + glu-L + h | Histidine Metabolism
0.5 | 1 | 0 | EC473 | histidinol-phosphate transaminase | [c]glu-L + imacp --> akg + hisp | Histidine Metabolism | EC-2.6.1.9
0.5 | 1 | 0 | EC472 | histidinol-phosphatase | [c]h2o + hisp --> histd + pi | Histidine Metabolism | EC-3.1.3.15
0.5 | 1 | 0 | EC471 | imidazoleglycerol-phosphate dehydratase | [c]eig3p --> h2o + imacp | Histidine Metabolism | EC-4.2.1.19
0.5 | 1 | 0 | EC470 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (irreversible) | [c]prfp --> prlp | Histidine Metabolism | EC-5.3.1.16
0.5 | 1 | 0 | EC436 | glutamine synthetase | [c]atp + glu-L + nh4 --> adp + gln-L + h + pi | Glutamate metabolism | EC-6.3.1.2
0.5 | 1 | 0 | EC378 | pantothenate synthase | [c]ala-B + atp + pant-R --> amp + h + pnto-R + ppi | Cofactor and Prosthetic Group Biosynthesis | EC-6.3.2.1
0.4985 | 0.997 | 0 | EC166 | argininosuccinate lyase | [c]argsuc <==> arg-L + fum | Arginine and Proline Metabolism | EC-4.3.2.1
0.4985 | 0.997 | 0 | EC165 | argininosuccinate synthase | [c]asp-L + atp + citr-L --> amp + argsuc + h + ppi | Arginine and Proline Metabolism | EC-6.3.4.5
0.4965 | 0.553 | 0.44 | EC238 | UDP-N-acetylenolpyruvoylglucosamine reductase | [c]h + nadph + uaccg --> nadp + uamr | Cell Envelope Biosynthesis | EC-1.1.1.158
0.4965 | 0.442 | 0.551 | R00550 | D-Glucose-1-phosphate:riboflavin 5\'-phosphotransferase | D-Glucose 1-phosphate + Riboflavin <=> D-Glucose + FMN |  | 2.7.1.42
0.494 | 0.426 | 0.562 | [NAME] | Malonyl-CoA:pyruvate carboxyltransferase | Malonyl-CoA + Pyruvate <=> Acetyl-CoA + Oxaloacetate | Propanoate metabolism | 2.1.3.1
0.491 | 0.974 | 0.008 | EC443 | phosphoserine phosphatase (L-serine) | [c]h2o + pser-L --> pi + ser-L | Glycine and Serine Metabolism | EC-3.1.3.3
0.488 | 0.976 | 0 | EC380 | 2-dehydropantoate 2-reductase | [c]2dhp + h + nadph --> nadp + pant-R | Cofactor and Prosthetic Group Biosynthesis | EC-1.1.1.169
0.4875 | 0.975 | 0 | EC924 | dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) | [c]23dhmb --> 3mob + h2o | [NAME], leucine, and isoleucine metabolism | EC-4.2.1.9
0.4855 | 0.545 | 0.426 | EC491 | 3-hydroxy-myristoyl-ACP synthesis | [c]ddcaACP + (2) h + malACP + nadph --> 3hmrsACP + ACP + co2 + nadp | Membrane Lipid Metabolism
0.4725 | 0.945 | 0 | EC511 | methionine synthase | [c]5mthf + hcys-L --> met-L + thf | [NAME] | EC-2.1.1.13
0.4655 | 0.531 | 0.4 | EC098 | phosphoglucomutase | [c]g1p <==> g6p | Alternate Carbon Metabolism | EC-5.4.2.2
0.4645 | 0.869 | 0.06 | EC722 | aspartate kinase | [c]asp-L + atp <==> 4pasp + adp | Threonine and Lysine Metabolism | EC-2.7.2.4
0.461 | 0.501 | 0.421 | EC375 | 4-amino-4-deoxychorismate synthase | [c]chor + gln-L --> 4adcho + glu-L | Cofactor and Prosthetic Group Biosynthesis
0.4585 | 0.917 | 0 | EC474 | histidinol dehydrogenase | [c]h2o + histd + (2) nad --> (3) h + his-L + (2) nadh | Histidine Metabolism | EC-1.1.1.23
0.453 | 0.906 | 0 | EC921 | ketol-acid reductoisomerase (2-Aceto-2-hydroxybutanoate) | [c]2ahbut + h + nadph --> 23dhmp + nadp | [NAME], leucine, and isoleucine metabolism | EC-1.1.1.86
0.451 | 0.899 | 0.003 | EC272 | aconitase | [c]cit <==> icit | Citrate Cycle (TCA) | EC-4.2.1.3
0.449 | 0.369 | 0.529 | R04726 | Dodecanoyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) | Dodecanoyl-[acyl-carrier protein] + Malonyl-[acyl-carrier protein] <=> 3-Oxotetradecanoyl-[acp] + CO2 + Acyl-carrier protein | Fatty acid biosynthesis | 2.3.1.41        2.3.1.85        2.3.1.86
0.446 | 0.585 | 0.307 | EC460 | glucose-6-phosphate isomerase | [c]g6p <==> f6p | Glycolysis/Gluconeogenesis | EC-5.3.1.9
0.4455 | 0.891 | 0 | EC919 | 2-aceto-2-hydroxybutanoate synthase | [c]2obut + h + pyr --> 2ahbut + co2 | [NAME], leucine, and isoleucine metabolism
0.4415 | 0.373 | 0.51 | R03191 | UDP-N-acetylmuramate:NADP+ oxidoreductase | UDP-N-acetylmuramate + NAD+ <=> UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine + NADH | Aminosugars metabolism | 1.1.1.158
0.4405 | 0.496 | 0.385 | EC893 | shikimate dehydrogenase | [c]3dhsk + h + nadph <==> nadp + skm | Tyrosine, Tryptophan, and [NAME] | EC-1.1.1.25
0.4355 | 0.459 | 0.412 | EC186 | Ornithine Decarboxylase | [c]h + orn --> co2 + ptrc | Arginine and Proline Metabolism | EC-4.1.1.17
0.433 | 0.866 | 0 | EC922 | acetohydroxy acid isomeroreductase | [c]alac-S + h + nadph --> 23dhmb + nadp | [NAME], leucine, and isoleucine metabolism | EC-1.1.1.86
0.431 | 0.509 | 0.353 | R00671 | L-Ornithine ammonia-lyase(cyclizing) | L-Ornithine <=> L-Proline + NH3 | Arginine and proline metabolism | 4.3.1.12
0.43 | 0.808 | 0.052 | EC370 | nicotinate-nucleotide diphosphorylase (carboxylating) | [c](2) h + prpp + quln --> co2 + nicrnt + ppi | Cofactor and Prosthetic Group Biosynthesis | EC-2.4.2.19
0.4265 | 0.273 | 0.58 | R01402 | 5\'-Methylthioadenosine:orthophosphate methylthio-D-ribosyltransferase | 5\'-Methylthioadenosine + Orthophosphate <=> Adenine + S-Methyl-5-thio-D-ribose 1-phosphate | Methionine metabolism | 2.4.2.28
0.4235 | 0.832 | 0.015 | EC379 | aspartate 1-decarboxylase | [c]asp-L + h --> ala-B + co2 | Cofactor and Prosthetic Group Biosynthesis | EC-4.1.1.11
0.423 | 0.839 | 0.007 | EC444 | phosphoserine transaminase | [c]3php + glu-L --> akg + pser-L | Glycine and Serine Metabolism | EC-2.6.1.52
0.423 | 0.839 | 0.007 | EC442 | phosphoglycerate dehydrogenase | [c]3pg + nad --> 3php + h + nadh | Glycine and Serine Metabolism | EC-1.1.1.95
0.423 | 0.338 | 0.508 | R03036 | Dephospho-CoA nucleotidohydrolase | Dephospho-CoA + H2O <=> Pantetheine 4\'-phosphate + AMP | Pantothenate and CoA biosynthesis | 3.6.1.9
0.42 | 0.84 | 0 | EC920 | acetolactate synthase | [c]h + (2) pyr --> alac-S + co2 | [NAME], leucine, and isoleucine metabolism | EC-4.1.3.18
0.42 | 0.414 | 0.426 | EC045 | UTP-glucose-1-phosphate uridylyltransferase | [c]g1p + h + utp <==> ppi + udpg | Alternate Carbon Metabolism | EC-2.7.7.9
0.4095 | 0.469 | 0.35 | EC234 | phosphoglucosamine mutase | [c]gam1p <==> gam6p | Cell Envelope Biosynthesis | EC-5.4.2.10
0.409 | 0.818 | 0 | EC377 | 3-methyl-2-oxobutanoate hydroxymethyltransferase | [c]3mob + h2o + mlthf --> 2dhp + thf | Cofactor and Prosthetic Group Biosynthesis | EC-2.1.2.11
0.404 | 0.382 | 0.426 | R00708 | L-1-Pyrroline-5-carboxylate:NAD+ oxidoreductase | (S)-1-Pyrroline-5-carboxylate + NADP+ + 2 H2O <=> L-Glutamate + NADPH + H+ | Glutamate metabolism,Arginine and proline metabolism | 1.5.1.12
0.4015 | 0.41 | 0.393 | EC537 | cytidylate kinase (CMP) | [c]atp + cmp <==> adp + cdp | Nucleotide Salvage Pathways | EC-2.7.4.14
0.399 | 0.798 | 0 | EC717 | diaminopimelate epimerase | [c]26dap-LL <==> 26dap-M | Threonine and Lysine Metabolism | EC-5.1.1.7
0.3965 | 0.378 | 0.415 | EC646 | thioredoxin reductase (NADPH) | [c]h + nadph + trdox --> nadp + trdrd | Oxidative phosphorylation | EC-1.6.4.5
0.3935 | 0.235 | 0.552 | R00845 | sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase | sn-Glycerol 3-phosphate + NADP+ <=> (2R)-2-Hydroxy-3-(phosphonooxy)-propanal + NADPH + H+ |  | 1.1.1.177
0.388 | 0.377 | 0.399 | EC208 | UTP-glucose-1-phosphate uridylyltransferase (irreversible) | [c]g1p + h + utp --> ppi + udpg | Cell Envelope Biosynthesis | EC-2.7.7.9
0.385 | 0.58 | 0.19 | EC680 | CTP synthase (glutamine) | [c]atp + gln-L + h2o + utp --> adp + ctp + glu-L + (2) h + pi | Purine and Pyrimidine Biosynthesis | EC-6.3.4.2
0.383 | 0.766 | 0 | EC716 | succinyl-diaminopimelate desuccinylase | [c]h2o + sl26da --> 26dap-LL + succ | Threonine and Lysine Metabolism | EC-3.5.1.18
0.383 | 0.766 | 0 | EC715 | tetrahydropicolinate succinylase | [c]h2o + succoa + thdp --> coa + sl2a6o | Threonine and Lysine Metabolism | EC-2.3.1.117
0.383 | 0.766 | 0 | EC711 | succinyldiaminopimelate transaminase | [c]akg + sl26da <==> [NAME] sl2a6o | Threonine and Lysine Metabolism | EC-2.6.1.17
0.379 | 0.318 | 0.44 | R06847 | shikimate:NAD+ 3-oxidoreductase | Shikimate + NAD+ <=> 3-Dehydroshikimate + NADH + H+ |  | 1.1.1.282
0.3765 | 0.326 | 0.427 | R06613 | 5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase | 5,10-Methylenetetrahydrofolate + dUMP + FADH2 <=> Tetrahydrofolate + dTMP + FAD | Pyrimidine metabolism,One carbon pool by folate | 2.1.1.148
0.375 | 0.41 | 0.34 | EC329 | dihydropteroate synthase | [c]4abz + 6hmhptpp --> dhpt + h + ppi | Cofactor and Prosthetic Group Biosynthesis
0.375 | 0.41 | 0.34 | EC328 | 6-hydroxymethyl-dihydropterin pyrophosphokinase | [c]6hmhpt + atp --> 6hmhptpp + amp + h | Cofactor and Prosthetic Group Biosynthesis
0.3745 | 0.685 | 0.064 | R00175 | S-Adenosyl-L-methionine hydrolase | S-Adenosyl-L-methionine + H2O <=> 5\'-Methylthioadenosine + L-Homoserine |  | 3.3.1.2
0.371 | 0.533 | 0.209 | EC440 | glycine hydroxymethyltransferase | [c]ser-L + thf --> gly + h2o + mlthf | Glycine and Serine Metabolism | EC-2.1.2.1
0.3705 | 0.443 | 0.298 | EC480 | acetyl-CoA carboxylate, reversible reaction | [c]accoa + atp + hco3 <==> adp + h + malcoa + pi | Membrane Lipid Metabolism | EC-6.4.1.2
0.369 | 0.728 | 0.01 | EC896 | prephenate dehydratase | [c]h + pphn --> co2 + h2o + phpyr | Tyrosine, Tryptophan, and [NAME] | EC-4.2.1.51
0.369 | 0.328 | 0.41 | R00985 | Chorismate pyruvate-lyase (amino-accepting) | Chorismate + NH3 <=> Anthranilate + Pyruvate + H2O | Phenylalanine, tyrosine and tryptophan biosynthesis | 4.1.3.27
0.3685 | 0.316 | 0.421 | R05552 |  | Chorismate + NH3 <=> 4-Amino-4-deoxychorismate + H2O | Folate biosynthesis
0.3645 | 0.332 | 0.397 | EC570 | ribonucleoside-diphosphate reductase (ADP) | [c]adp + trdrd --> dadp + h2o + trdox | Nucleotide Salvage Pathways | [NAME]
0.3635 | 0.319 | 0.408 | R00936 | 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase | Tetrahydrofolate + NAD+ <=> Dihydrofolate + NADH + H+ | One carbon pool by folate | 1.5.1.3
0.363 | 0.38 | 0.346 | EC374 | Dihydroneopterin triphosphate pyrophosphatase | [c]ahdt + h2o --> dhpmp + h + ppi | Cofactor and Prosthetic Group Biosynthesis
0.363 | 0.38 | 0.346 | [NAME] | Dihydroneopterin monophosphate dephosphorylase | [c]dhpmp + h2o --> dhnpt + pi | Cofactor and Prosthetic Group Biosynthesis
0.3525 | 0.273 | 0.432 | EC900 | tryptophan synthase (indoleglycerol phosphate) | [c]3ig3p --> g3p + indole | Tyrosine, Tryptophan, and [NAME] | EC-4.2.1.20
0.3425 | 0.339 | 0.346 | R01148 | D-Alanine:2-oxoglutarate aminotransferase | D-Alanine + 2-Oxoglutarate <=> Pyruvate + D-Glutamate | D-Alanine metabolism | 2.6.1.21
0.3415 | 0.429 | 0.254 | EC324 | dihydrofolate reductase | [c]dhf + h + nadph <==> nadp + thf | Cofactor and Prosthetic Group Biosynthesis | EC-1.5.1.3
0.3415 | 0.283 | 0.4 | EC488 | b-ketoacyl synthase | [c]acACP + h + malACP --> ACP + actACP + co2 | Membrane Lipid Metabolism
0.3405 | 0.39 | 0.291 | EC244 | glutamate racemase | [c]glu-D <==> [NAME] | Cell Envelope Biosynthesis | EC-5.1.1.3
0.34 | 0.675 | 0.005 | [NAME] | [NAME] | [c]thr-L <==> acald + gly | Threonine and Lysine Metabolism | EC-4.1.2.5
0.34 | 0.307 | 0.373 | R02060 | D-Glucosamine 1-phosphate 1,6-phosphomutase; D-glucosamine 1,6-phosphomutase | alpha-D-Glucosamine 1-phosphate <=> D-Glucosamine 6-phosphate | Aminosugars metabolism | 5.4.2.10
0.3385 | 0.148 | 0.529 | R01221 | glycine synthase | Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NH3 + CO2 + NADH + H+ | Nitrogen metabolism | 2.1.2.10
0.338 | 0 | 0.676 | EC372 | nicotinamide-nucleotide adenylyltransferase | [c]atp + h + nmn --> nad + ppi | Cofactor and Prosthetic Group Biosynthesis | EC-2.7.7.1
0.333 | 0.326 | 0.34 | R07226 | acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase(glycine-forming) | Acetyl phosphate + NH3 + Oxidized thioredoxin <=> Glycine + Orthophosphate + Thioredoxin |  | 1.21.4.2
0.331 | 0.534 | 0.128 | [NAME] | NAD synthase (nh3) | [c]atp + dnad + nh4 --> amp + h + nad + ppi | Cofactor and Prosthetic Group Biosynthesis | EC-6.3.1.5
0.329 | 0.657 | 0.001 | EC167 | ornithine carbamoyltransferase | [c]cbp + orn <==> citr-L + h + pi | Arginine and Proline Metabolism | EC-2.1.3.3
0.3275 | 0.309 | 0.346 | R00670 | L-Ornithine carboxy-lyase | L-Ornithine <=> Putrescine + CO2 | Urea cycle and metabolism of amino groups,Arginine and proline metabolism | 4.1.1.17
0.3245 | 0.2 | 0.449 | EC150 | 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction | [c]dkmpp + (3) h2o --> 2kmb + for + (6) h + pi | Arginine and Proline Metabolism
0.324 | 0.647 | 0.001 | EC510 | [NAME] | [c]cyst-L + h2o --> hcys-L + nh4 + pyr | [NAME] | EC-4.4.1.8
0.319 | 0.361 | 0.277 | EC181 | pyrroline-5-carboxylate reductase | [c]1pyr5c + (2) h + nadph --> nadp + pro-L | Arginine and Proline Metabolism | EC-1.5.1.2
0.3085 | 0.206 | 0.411 | EC156 | 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction | [c]dkmpp + h2o + o2 --> 2kmb + for + (2) h + pi | Arginine and Proline Metabolism
0.3025 | 0.232 | 0.373 | EC571 | ribonucleoside-diphosphate reductase (GDP) | [c]gdp + trdrd --> dgdp + h2o + trdox | Nucleotide Salvage Pathways | [NAME]
0.301 | 0.59 | 0.012 | EC907 | [NAME] | [c]akg + tyr-L <==> 34hpp + glu-L | Tyrosine, Tryptophan, and [NAME] | EC-2.6.1.5
0.2955 | 0.396 | 0.195 | EC592 | 5'-nucleotidase (CMP) | [c]cmp + h2o --> cytd + pi | Nucleotide Salvage Pathways | EC-3.1.3.5
0.2955 | 0.265 | 0.326 | R01248 | L-Proline:NAD+ 5-oxidoreductase | L-Proline + NAD+ <=> (S)-1-Pyrroline-5-carboxylate + NADH + H+ | Urea cycle and metabolism of amino groups,Arginine and proline metabolism | 1.5.1.2
0.2955 | 0.25 | 0.341 | R01067 | D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase | D-Fructose 6-phosphate + (2R)-2-Hydroxy-3-(phosphonooxy)-propanal <=> D-Erythrose 4-phosphate + D-Xylulose 5-phosphate | Carbon fixation | 2.2.1.1
0.2925 | 0.584 | 0.001 | R04209 | 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase | 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate <=> Aminoimidazole ribotide + CO2 | Purine metabolism | 4.1.1.21
0.292 | 0.584 | 0 | EC164 | acetylornithine deacetylase | [c]acorn + h2o --> ac + orn | Arginine and Proline Metabolism | EC-3.5.1.16
0.291 | 0.383 | 0.199 | EC655 | transketolase | [c]e4p + xu5p-D <==> f6p + g3p | Pentose Phosphate Cycle | EC-2.2.1.1
0.289 | 0.576 | 0.002 | EC667 | phosphoribosylaminoimidazolecarboxamide formyltransferase | [c]10fthf + aicar <==> fprica + thf | Purine and Pyrimidine Biosynthesis | EC-2.1.2.3
0.2885 | 0.577 | 0 | EC422 | Sulfate adenyltransferase | [c]atp + gtp + h2o + so4 --> aps + gdp + pi + ppi | Cysteine Metabolism
0.2885 | 0.25 | 0.327 | R04230 | (R)-4\'-Phosphopantothenate:L-cysteine ligase | ATP + D-4\'-Phosphopantothenate + L-Cysteine <=> ADP + Orthophosphate + (R)-4\'-Phosphopantothenoyl-L-cysteine | Pantothenate and CoA biosynthesis | 6.3.2.5
0.2835 | 0.333 | 0.234 | EC297 | phosphopantothenate-cysteine ligase | [c]4ppan + ctp + cys-L --> 4ppcys + cmp + h + ppi | Cofactor and Prosthetic Group Biosynthesis | EC-6.3.2.5
0.2825 | 0.443 | 0.122 | [NAME] | AMP,sulfite:thioredoxin-disulfide oxidoreductase(adenosine-5\'-phosphosulfate-forming) | AMP + Sulfite + Oxidized thioredoxin <=> Adenylylsulfate + Thioredoxin |  | 1.8.4.10
0.282 | 0.561 | 0.003 | EC927 | leucine transaminase (irreversible) | [c]4mop + glu-L --> akg + leu-L | [NAME], leucine, and isoleucine metabolism | EC-2.6.1.42
0.281 | 0.562 | 0 | EC714 | dihydrodipicolinate reductase (NADPH) | [c]23dhdp + h + nadph --> nadp + thdp | Threonine and Lysine Metabolism | EC-1.3.1.26
0.281 | 0.558 | 0.004 | EC161 | N-acetyl-g-glutamyl-phosphate reductase | [c]acg5sa + nadp + pi <==> acg5p + h + nadph | Arginine and Proline Metabolism | EC-1.2.1.38
0.281 | 0.558 | 0.004 | EC160 | acetylglutamate kinase | [c]acglu + atp --> acg5p + adp | Arginine and Proline Metabolism | EC-2.7.2.8
0.2795 | 0.247 | 0.312 | R04233 | (R)-4\'-Phosphopantothenate:L-cysteine ligase | CTP + D-4\'-Phosphopantothenate + L-Cysteine <=> CDP + Orthophosphate + (R)-4\'-Phosphopantothenoyl-L-cysteine | Pantothenate and CoA biosynthesis | 6.3.2.5
0.276 | 0.552 | 0 | EC666 | glutamine phosphoribosyldiphosphate amidotransferase | [c]gln-L + h2o + prpp --> glu-L + ppi + pram | Purine and Pyrimidine Biosynthesis | EC-2.4.2.14
0.2715 | 0.347 | 0.196 | [NAME] | UTP:ammonia ligase(ADP-forming) | ATP + UTP + NH3 <=> ADP + Orthophosphate + CTP | Pyrimidine metabolism | 6.3.4.2
0.2715 | 0.046 | 0.497 | EC533 | adenine phosphoribosyltransferase | [c]ade + prpp --> amp + ppi | Nucleotide Salvage Pathways | EC-2.4.2.7
0.2675 | 0.511 | 0.024 | EC712 | aspartate-semialdehyde dehydrogenase | [c]aspsa + nadp + pi <==> 4pasp + h + nadph | Threonine and Lysine Metabolism | EC-1.2.1.11
0.262 | 0.381 | 0.143 | R00257 | Deamido-NAD+:L-glutamine amido-ligase (AMP-forming) | ATP + Deamino-NAD+ + L-Glutamine + H2O <=> AMP + Pyrophosphate + NAD+ + L-Glutamate | Glutamate metabolism,Nicotinate and nicotinamide metabolism | 6.3.5.1
0.2605 | 0.52 | 0.001 | EC278 | isocitrate dehydrogenase (NADP) | [c]icit + nadp <==> akg + co2 + nadph | Citrate Cycle (TCA) | EC-1.1.1.42
0.2565 | 0.51 | 0.003 | EC918 | L-threonine deaminase | [c]thr-L --> 2obut + nh4 | [NAME], leucine, and isoleucine metabolism
0.2505 | 0.212 | 0.289 | R01224 | 5-Methyltetrahyfrofolate:(acceptor) oxidoreductase; 5-Methyltetrahydrofolate:NADP+ oxidoreductase | 5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+ | One carbon pool by folate,Methane metabolism | 1.5.1.20
0.249 | 0.173 | 0.325 | EC178 | methylthioadenosine nucleosidase | [c]5mta + h2o --> 5mtr + ade | Arginine and Proline Metabolism | EC-3.2.2.16
0.249 | 0.173 | 0.325 | EC154 | 5-methylthioribose kinase | [c]5mtr + atp --> 5mdr1p + adp + h | Arginine and Proline Metabolism | EC-2.7.1.100
0.247 | 0.464 | 0.03 | EC721 | homoserine dehydrogenase (NADPH) | [c]hom-L + nadp <==> aspsa + h + nadph | Threonine and Lysine Metabolism | EC-1.1.1.3
0.246 | 0.491 | 0.001 | EC277 | citrate synthase | [c]accoa + h2o + oaa --> cit + coa + h | Citrate Cycle (TCA) | EC-4.1.3.7
0.2455 | 0.211 | 0.28 | R00572 | CTP:pyruvate O2-phosphotransferase | CTP + Pyruvate <=> CDP + Phosphoenolpyruvate |  | 2.7.1.40
0.244 | 0.488 | 0 | [NAME] | acetylornithine transaminase | [c]acorn + akg <==> acg5sa + glu-L | Arginine and Proline Metabolism | EC-2.6.1.11
0.244 | 0.484 | 0.004 | EC159 | N-acetylglutamate synthase | [c]accoa + glu-L --> acglu + coa + h | Arginine and Proline Metabolism | EC-2.3.1.1
0.2405 | 0.229 | 0.252 | EC464 | triose-phosphate isomerase | [c]dhap <==> [NAME] | Glycolysis/Gluconeogenesis | EC-5.3.1.1
0.24 | 0.197 | 0.283 | R00432 | Succinate:CoA ligase (GDP-forming) | GTP + Succinate + CoA <=> GDP + Orthophosphate + Succinyl-CoA | Citrate cycle (TCA cycle),Propanoate metabolism | 6.2.1.4
0.24 | 0.184 | 0.296 | R01829 | Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase | Sedoheptulose 1,7-bisphosphate <=> Glycerone phosphate + D-Erythrose 4-phosphate | Carbon fixation | 4.1.2.13
0.239 | 0.207 | 0.271 | EC573 | ribonucleoside-diphosphate reductase (CDP) | [c]cdp + trdrd --> dcdp + h2o + trdox | Nucleotide Salvage Pathways | [NAME]
0.2385 | 0.2 | 0.277 | R00761 | D-Fructose-6-phosphate D-erythrose-4-phosphate-lyase | D-Fructose 6-phosphate + Orthophosphate <=> Acetyl phosphate + D-Erythrose 4-phosphate + H2O | Pentose phosphate pathway,Carbon fixation | 4.1.2.9         4.1.2.22
0.2355 | 0.36 | 0.111 | EC452 | fructose 6-phosphate aldolase | [c]f6p <==> dha + g3p | Glycolysis/Gluconeogenesis
0.2355 | 0.333 | 0.138 | EC450 | fructose-bisphosphate aldolase | [c]fdp <==> dhap + g3p | Glycolysis/Gluconeogenesis | EC-4.1.2.13
0.2345 | 0.188 | 0.281 | R01222 | 5-Methyltetrahyfrofolate:(acceptor) oxidoreductase | 5,10-Methylenetetrahydrofolate + FADH2 <=> 5-Methyltetrahydrofolate + FAD | One carbon pool by folate,Methane metabolism | 1.5.1.20
0.2325 | 0.099 | 0.366 | R00265 | 2-Oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating) | 2-Oxoglutarate + CoA + NADP+ <=> Succinyl-CoA + CO2 + NADPH |  | 1.2.1.52
0.232 | 0.221 | 0.243 | [NAME] | D-Xylulose 5-phosphate D-glyceraldehyde-3-phosphate-lyase | D-Xylulose 5-phosphate + Orthophosphate <=> Acetyl phosphate + (2R)-2-Hydroxy-3-(phosphonooxy)-propanal + H2O | Pentose phosphate pathway,Methane metabolism,Carbon fixation | 4.1.2.9
0.2285 | 0.253 | 0.204 | [NAME] | L-glutamate 5-semialdehyde dehydratase (spontaneous) | [c]glu5sa --> 1pyr5c + h + h2o | Arginine and Proline Metabolism
0.2255 | 0.366 | 0.085 | R00860 | AMP,sulfite:(acceptor) oxidoreductase | Sulfite + Acceptor + AMP <=> [NAME] acceptor | Sulfur metabolism | 1.8.99.2
0.225 | 0.288 | 0.162 | EC432 | 5,10-methylenetetrahydrofolate reductase (NADH) | [c]h + mlthf + nadh --> 5mthf + nad | Folate Metabolism
0.2245 | 0.448 | 0.001 | R06975 | 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5\'-monophosphate synthetase | Formate + ATP + 1-(5\'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide <=> ADP + Orthophosphate + 1-(5\'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide |  | 6.3.4.-
0.22 | 0.438 | 0.002 | R07274 | O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase | O-Phospho-L-serine + Hydrogen sulfide <=> L-Cysteine + Orthophosphate |  | 2.5.1.65
0.22 | 0.02 | 0.42 | EC553 | [NAME] | [c]atp + gsn --> adp + gmp + h | Nucleotide Salvage Pathways
0.217 | 0.43 | 0.004 | EC672 | phosphoribosylglycinamide formyltransferase | [c]10fthf + gar <==> fgam + h + thf | Purine and Pyrimidine Biosynthesis | EC-2.1.2.2
0.215 | 0.427 | 0.003 | EC673 | GAR transformylase-T | [c]atp + for + gar --> adp + fgam + h + pi | Purine and Pyrimidine Biosynthesis
0.214 | 0.29 | 0.138 | R00726 | ITP:oxaloacetate carboxy-lyase (transphosphorylating) | ITP + Oxaloacetate <=> IDP + Phosphoenolpyruvate + CO2 | Citrate cycle (TCA cycle),Pyruvate metabolism | 4.1.1.32
0.2125 | 0.425 | 0 | R01398 | Carbamoyl-phosphate:L-ornithine carbamoyltransferase | Carbamoyl phosphate + L-Ornithine <=> Orthophosphate + L-Citrulline | Urea cycle and metabolism of amino groups,Arginine and proline metabolism | 2.1.3.3
0.2115 | 0.233 | 0.19 | EC650 | phosphogluconate dehydrogenase | [c]6pgc + nadp --> co2 + nadph + ru5p-D | Pentose Phosphate Cycle | EC-1.1.1.44
0.2085 | 0.184 | 0.233 | EC567 | nucleoside-diphosphate kinase (ATP:dCDP) | [c]atp + dcdp <==> adp + dctp | Nucleotide Salvage Pathways | EC-2.7.4.6
0.204 | 0.407 | 0.001 | EC147 | phosphoenolpyruvate carboxylase | [c]co2 + h2o + pep --> h + oaa + pi | Anaplerotic reactions | EC-4.1.1.31
0.2015 | 0.281 | 0.122 | EC912 | HCO3 equilibration reaction | [c]co2 + h2o <==> h + hco3 | Unassigned
0.2015 | 0.169 | 0.234 | [NAME] | 3-Deoxy-D-manno-octulosonate D-arabinose-lyase | 3-Deoxy-D-manno-octulosonate <=> Pyruvate + D-Arabinose |  | 4.1.2.23
0.198 | 0.393 | 0.003 | R01001 | L-Cystathionine Lysteine-lyase (deaminating) | L-Cystathionine + H2O <=> L-Cysteine + NH3 + 2-Oxobutanoate | Glycine, serine and threonine metabolism,[NAME] metabolism,Nitrogen metabolism | 4.4.1.1
0.1975 | 0.007 | 0.388 | EC551 | guanine phosphoribosyltransferase | [c]gua + prpp --> gmp + ppi | Nucleotide Salvage Pathways
0.1965 | 0.224 | 0.169 | R00245 | L-Glutamate 5-semialdehyde:NAD+ oxidoreductase | L-Glutamate 5-semialdehyde + NAD+ + H2O <=> L-Glutamate + NADH + H+ | Arginine and proline metabolism | 1.5.1.12
0.195 | 0.228 | 0.162 | EC546 | dUTP diphosphatase | [c]dutp + h2o --> dump + h + ppi | Nucleotide Salvage Pathways | EC-3.6.1.23
0.194 | 0.388 | 0 | EC724 | threonine synthase | [c]h2o + phom --> pi + thr-L | Threonine and Lysine Metabolism | EC-4.2.3.1
0.194 | 0.388 | 0 | EC723 | [NAME] | [c]atp + hom-L --> adp + h + phom | Threonine and Lysine Metabolism | EC-2.7.1.39
0.194 | 0.385 | 0.003 | R00782 | L-Cysteine L-homocysteine-lyase (deaminating) | L-Cysteine + H2O <=> Hydrogen sulfide + Pyruvate + NH3 | Cysteine metabolism | 4.4.1.1         4.4.1.8
0.1915 | 0.129 | 0.254 | R00430 | GTP:pyruvate O2-phosphotransferase | GTP + Pyruvate <=> GDP + Phosphoenolpyruvate | Purine metabolism | 2.7.1.40
0.1865 | 0.216 | 0.157 | R00344 | Pyruvate:carbon-dioxide ligase (ADP-forming) | ATP + Pyruvate + HCO3- <=> ADP + Orthophosphate + Oxaloacetate | Citrate cycle (TCA cycle),Alanine and aspartate metabolism,Pyruvate metabolism | 6.4.1.1
0.186 | 0.372 | 0 | EC669 | phosphoribosylaminoimidazole carboxylase | [c]air + atp + hco3 --> 5caiz + adp + h + pi | Purine and Pyrimidine Biosynthesis
0.186 | 0.372 | 0 | EC665 | phosphoribosylaminoimidazole carboxylase (mutase rxn) | [c]5aizc <==> 5caiz | Purine and Pyrimidine Biosynthesis
0.186 | 0.153 | 0.219 | EC898 | Tryptophanase (L-tryptophan) | [c]h2o + trp-L <==> indole + nh4 + pyr | Tyrosine, Tryptophan, and [NAME] | EC-4.1.99.1
0.1855 | 0.182 | 0.189 | EC578 | uridylate kinase (dUMP) | [c]atp + dump <==> adp + dudp | Nucleotide Salvage Pathways
0.185 | 0.367 | 0.003 | R01088 | L-leucine:NAD+ oxidoreductase(deaminating) | L-Leucine + H2O + NAD+ <=> 4-Methyl-2-oxopentanoate + NH3 + NADH + H+ | [NAME], leucine and isoleucine degradation,[NAME], leucine and isoleucine biosynthesis | 1.4.1.9
0.184 | 0.126 | 0.242 | R00346 | Pyrophosphate:oxaloacetate carboxy-lyase (transphosphorylating) | Pyrophosphate + Oxaloacetate <=> Orthophosphate + Phosphoenolpyruvate + CO2 | Pyruvate metabolism | 4.1.1.38
0.1835 | 0.367 | 0 | R04198 | 2,3,4,5-Tetrahydrodipicolinate:NAD+ oxidoreductase | 2,3,4,5-Tetrahydrodipicolinate + NAD+ <=> L-2,3-Dihydrodipicolinate + NADH + H+ | Lysine biosynthesis | 1.3.1.26
0.1835 | 0.123 | 0.244 | R01197 |  | Reduced ferredoxin + Succinyl-CoA + CO2 <=> Oxidized ferredoxin + 2-Oxoglutarate + CoA | Citrate cycle (TCA cycle),Reductive carboxylate cycle (CO2 fixation) | 1.2.7.3
0.182 | 0.228 | 0.136 | EC063 | gluconokinase | [c]atp + glcn --> 6pgc + adp + h | Alternate Carbon Metabolism | EC-2.7.1.12
0.179 | 0.145 | 0.213 | EC899 | tryptophan synthase (indole) | [c]indole + ser-L --> h2o + trp-L | Tyrosine, Tryptophan, and [NAME] | EC-4.2.1.20
0.1785 | 0.352 | 0.005 | R00529 | ATP:sulfate adenylyltransferase | ATP + Sulfate <=> Pyrophosphate + Adenylylsulfate | Purine metabolism,[NAME] metabolism | 2.7.7.4
0.178 | 0.351 | 0.005 | R00709 | Isocitrate:NAD+ oxidoreductase (decarboxylating) | Isocitrate + NAD+ <=> 2-Oxoglutarate + CO2 + NADH + H+ | Citrate cycle (TCA cycle) | 1.1.1.41        1.1.1.286
0.1755 | 0.351 | 0 | EC508 | homoserine O-succinyltransferase | [c]hom-L + succoa --> coa + suchms | [NAME] | EC-2.3.1.46
0.174 | 0.347 | 0.001 | R01053 | Ribose-5-phosphate:ammonia ligase (ADP-forming) | ATP + D-Ribose 5-phosphate + NH3 <=> ADP + Orthophosphate + 5-Phosphoribosylamine | Purine metabolism | 6.3.4.7
0.174 | 0.149 | 0.199 | R00659 | UTP:pyruvate O2-phosphotransferase | UTP + Pyruvate <=> UDP + Phosphoenolpyruvate |  | 2.7.1.40
0.172 | 0.146 | 0.198 | EC495 | Acetyl-CoA ACP transacylase | [c]ACP + accoa <==> acACP + coa | Membrane Lipid Metabolism | EC-2.3.1.38
0.1695 | 0.338 | 0.001 | EC681 | Carbamate kinase | [c]atp + co2 + nh4 --> adp + cbp + (2) h | Putative | EC-2.7.2.2
0.168 | 0.334 | 0.002 | R00352 | ATP:citrate oxaloacetate-lyase ((pro-3S)-CH2COO- ->acetyl-CoA) (ATP-dephosphorylating) | ATP + Citrate + CoA <=> ADP + Orthophosphate + Acetyl-CoA + Oxaloacetate | Citrate cycle (TCA cycle),Reductive carboxylate cycle (CO2 fixation) | 2.3.3.8
0.165 | 0.143 | 0.187 | EC184 | arginine decarboxylase | [c]arg-L + h --> agm + co2 | Arginine and Proline Metabolism | EC-4.1.1.19
0.164 | 0.3 | 0.028 | R01773 | L-Homoserine:NAD+ oxidoreductase | L-Homoserine + NAD+ <=> L-Aspartate 4-semialdehyde + NADH + H+ | Glycine, serine and threonine metabolism,Lysine biosynthesis | 1.1.1.3
0.164 | 0.152 | 0.176 | R01860 | 4-Aminobenzoate carboxy-lyase | 4-Aminobenzoate <=> Aniline + CO2 |  | 4.1.1.24
0.164 | 0.152 | 0.176 | R00990 | 2-Aminobenzoate carboxy-lyase | Anthranilate <=> Aniline + CO2 |  | 4.1.1.24
0.1635 | 0.28 | 0.047 | R01058 | D-glyceraldehyde 3-phosphate:NADP+ oxidoreductase | (2R)-2-Hydroxy-3-(phosphonooxy)-propanal + NADP+ + H2O <=> 3-Phospho-D-glycerate + NADPH + H+ |  | 1.2.1.9
0.1635 | 0.126 | 0.201 | R00320 | Pyrophosphate:acetate phosphotransferase | Pyrophosphate + Acetate <=> Orthophosphate + Acetyl phosphate | Pyruvate metabolism | 2.7.2.12
0.1625 | 0.321 | 0.004 | EC906 | prephenate dehydrogenase | [c]nad + pphn --> 34hpp + co2 + nadh | Tyrosine, Tryptophan, and [NAME] | EC-1.3.1.12
0.1615 | 0.129 | 0.194 | R02086 | N-Acetyl-D-glucosamine 1-phosphate 1,6-phosphomutase | N-Acetyl-D-glucosamine 6-phosphate <=> N-Acetyl-D-glucosamine 1-phosphate | Aminosugars metabolism | 5.4.2.3
0.1615 | 0.121 | 0.202 | EC487 | Malonyl-ACP decarboxylase | [[NAME] --> acACP + co2 | Membrane Lipid Metabolism
0.1605 | 0.14 | 0.181 | [NAME] | CTP:D-fructose-6-phosphate 1-phosphotransferase | CTP + D-Fructose 6-phosphate <=> CDP + D-Fructose 1,6-bisphosphate |  | 2.7.1.11
0.16 | 0.285 | 0.035 | [NAME] | L-Aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating) | L-Aspartate 4-semialdehyde + Orthophosphate + NADP+ <=> 4-Phospho-L-aspartate + NADPH + H+ | Glycine, serine and threonine metabolism,Lysine biosynthesis | 1.2.1.11
0.16 | 0.15 | 0.17 | R00769 | UTP:D-fructose-6-phosphate 1-phosphotransferase | UTP + D-Fructose 6-phosphate <=> UDP + D-Fructose 1,6-bisphosphate |  | 2.7.1.11
0.16 | 0.102 | 0.218 | EC521 | CMP nucleosidase | [c]cmp + h2o --> csn + r5p | Nucleotide Salvage Pathways | EC-3.2.2.10
0.1565 | 0.151 | 0.162 | R02038 | CTP:ethanolamine-phosphate cytidylyltransferase | CTP + Ethanolamine phosphate <=> Pyrophosphate + CDP-ethanolamine | Glycerophospholipid metabolism | 2.7.7.14
0.1555 | 0.134 | 0.177 | EC431 | Glycine Cleavage System | [c]gly + nad + thf --> co2 + mlthf + nadh + nh4 | Folate Metabolism
0.1545 | 0.151 | 0.158 | R00764 | Pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase | Pyrophosphate + D-Fructose 6-phosphate <=> Orthophosphate + D-Fructose 1,6-bisphosphate |  | 2.7.1.90
0.154 | 0.084 | 0.224 | R01858 | dATP:pyruvate O2-phosphotransferase | dGTP + Pyruvate <=> dGDP + Phosphoenolpyruvate | Purine metabolism | 2.7.1.40
0.1535 | 0.142 | 0.165 | R00157 | Uridine triphosphate:AMP phosphotransferase | UTP + AMP <=> UDP + ADP | Pyrimidine metabolism | 2.7.4.10
0.153 | 0.303 | 0.003 | EC006 | asparagine synthase (glutamine-hydrolysing) | [c]asp-L + atp + gln-L + h2o --> amp + asn-L + glu-L + h + ppi | Alanine and aspartate metabolism | EC-6.3.5.4
0.153 | 0.008 | 0.298 | EC602 | purine-nucleoside phosphorylase (Adenosine) | [c]adn + pi <==> ade + r1p | Nucleotide Salvage Pathways | EC-2.4.2.1
0.1525 | 0.202 | 0.103 | R00667 | L-Ornithine:2-oxo-acid aminotransferase | L-Ornithine + 2-Oxoglutarate <=> L-Glutamate 5-semialdehyde + L-Glutamate | Urea cycle and metabolism of amino groups,Arginine and proline metabolism | 2.6.1.13
0.152 | 0.132 | 0.172 | R01573 | ATP:D-arabinose 5-phosphotransferase | ATP + D-Arabinose <=> ADP + D-Arabinose 5-phosphate |  | 2.7.1.54
0.1505 | 0.123 | 0.178 | R01217 | 5-methyltetrahydrofolate:ferredoxin oxidoreductase | 5,10-Methylenetetrahydrofolate + Reduced ferredoxin <=> 5-Methyltetrahydrofolate + Oxidized ferredoxin | One carbon pool by folate | 1.5.7.1         1.7.7.-
0.149 | 0.124 | 0.174 | R02058 | Acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase | Acetyl-CoA + D-Glucosamine 6-phosphate <=> CoA + N-Acetyl-D-glucosamine 6-phosphate | Glutamate metabolism,Aminosugars metabolism | 2.3.1.4
0.1485 | 0.134 | 0.163 | R05839 | pyridoxamine:2-oxoglutarate aminotransferase | Pyridoxamine + 2-Oxoglutarate <=> Pyridoxal + D-Glutamate | [NAME] metabolism | 2.6.1.54
0.148 | 0.296 | 0 | EC509 | O-succinylhomoserine lyase (L-cysteine) | [c]cys-L + suchms --> cyst-L + h + succ | [NAME] | EC-4.2.99.9
0.148 | 0.296 | 0 | [NAME] | asparagine synthetase | [c]asp-L + atp + nh4 --> amp + asn-L + h + ppi | Alanine and aspartate metabolism | EC-6.3.1.1
0.1475 | 0.164 | 0.131 | EC577 | ribonucleoside-triphosphate reductase (UTP) | [c]trdrd + utp --> dutp + h2o + trdox | Nucleotide Salvage Pathways | EC-1.17.4.2
0.1475 | 0 | 0.295 | R00568 | CTP aminohydrolase | CTP + H2O <=> UTP + NH3 | Pyrimidine metabolism | 3.5.4.13
0.147 | 0.286 | 0.008 | EC429 | methenyltetrahydrofolate cyclohydrolase | [c]h2o + methf <==> 10fthf | Folate Metabolism | EC-3.5.4.9
0.1465 | 0.292 | 0.001 | R02200 | Valine:(S)-3-methyl-2-oxopentanoate aminotransferase | L-Valine + (S)-3-Methyl-2-oxopentanoic acid <=> 3-Methyl-2-oxobutanoic acid + L-Isoleucine |  | 2.6.1.32
0.144 | 0.202 | 0.086 | EC528 | adentylate kinase (GTP) | [c]amp + gtp <==> adp + gdp | Nucleotide Salvage Pathways
0.144 | 0.118 | 0.17 | R01846 | CTP:Sedoheptulose 7-phosphate 1-phosphotransferase | CTP + Sedoheptulose 7-phosphate <=> CDP + Sedoheptulose 1,7-bisphosphate |  | 2.7.1.11
0.142 | 0.129 | 0.155 | EC565 | nucleoside-diphosphate kinase (ATP:dGDP) | [c]atp + dgdp <==> adp + dgtp | Nucleotide Salvage Pathways | EC-2.7.4.6
0.142 | 0.111 | 0.173 | R01830 | beta-D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase | beta-D-Fructose 6-phosphate + (2R)-2-Hydroxy-3-(phosphonooxy)-propanal <=> D-Erythrose 4-phosphate + D-Xylulose 5-phosphate | Pentose phosphate pathway | 2.2.1.1
0.138 | 0.133 | 0.143 | R01663 | dCMP aminohydrolase | dCMP + H2O <=> dUMP + NH3 | Pyrimidine metabolism | 3.5.4.12
0.138 | 0.126 | 0.15 | R00748 | Ethanolamine-phosphate phospho-lyase (deaminating) | Ethanolamine phosphate + H2O <=> Acetaldehyde + NH3 + Orthophosphate |  | 4.2.3.2
0.137 | 0.135 | 0.139 | EC572 | ribonucleoside-diphosphate reductase (UDP) | [c]trdrd + udp --> dudp + h2o + trdox | Nucleotide Salvage Pathways | [NAME]
0.136 | 0.12 | 0.152 | EC185 | agmatinase | [c]agm + h2o --> ptrc + urea | Arginine and Proline Metabolism | EC-3.5.3.11
0.1315 | 0.081 | 0.182 | EC539 | Cytosine deaminase | [c]csn + h + h2o --> nh4 + ura | Nucleotide Salvage Pathways | EC-3.5.4.1
0.1315 | 0.008 | 0.255 | EC534 | cytidine deaminase | [c]cytd + h + h2o --> nh4 + uri | Nucleotide Salvage Pathways | EC-3.5.4.5
0.13 | 0.11 | 0.15 | R01847 | UTP:Sedoheptulose 7-phosphate 1-phosphotransferase | UTP + Sedoheptulose 7-phosphate <=> UDP + Sedoheptulose 1,7-bisphosphate |  | 2.7.1.11
0.1295 | 0.095 | 0.164 | R04180 | 6-(D-Glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase | 6-(D-Glucose-1-phospho)-D-mannosylglycoprotein + H2O <=> D-Glucose 1-phosphate + D-Mannosylglycoprotein |  | 3.1.4.51
0.1295 | 0.095 | 0.164 | R04179 | UDPglucose:glycoprotein-D-mannose glucosephosphotransferase | UDP-glucose + D-Mannosylglycoprotein <=> UMP + 6-(D-Glucose-1-phospho)-D-mannosylglycoprotein |  | 2.7.8.19
0.1285 | 0.251 | 0.006 | EC173 | carbamoyl-phosphate synthase (glutamine-hydrolysing) | [c](2) atp + gln-L + h2o + hco3 --> (2) adp + cbp + glu-L + (2) h + pi | Arginine and Proline Metabolism | [NAME]
0.1285 | 0.231 | 0.026 | EC710 | pyruvate formate lyase | [c]coa + pyr --> accoa + for | Pyruvate metabolism | EC-Undetermined
0.127 | 0.004 | 0.25 | EC586 | uracil phosphoribosyltransferase | [c]prpp + ura --> ppi + ump | Nucleotide Salvage Pathways | EC-2.4.2.9
0.126 | 0.252 | 0 | EC003 | alanine racemase | [c]ala-L <==> ala-D | Alanine and aspartate metabolism | EC-5.1.1.1
0.126 | 0.105 | 0.147 | R05805 | ADP:D-fructose-6-phosphate 1-phosphotransferase | ADP + D-Fructose 6-phosphate <=> AMP + D-Fructose 1,6-bisphosphate |  | 2.7.1.146
0.1245 | 0.248 | 0.001 | EC425 | sulfite reductase (NADPH2) | [c](3) h2o + h2s + (3) nadp <==> (5) h + (3) nadph + so3 | Cysteine Metabolism | EC-1.8.2.2
0.124 | 0.248 | 0 | EC925 | isoleucine transaminase | [c]akg + ile-L <==> [NAME] | [NAME], leucine, and isoleucine metabolism | EC-2.6.1.42
0.124 | 0.236 | 0.012 | R00691 | L-Arogenate hydro-lyase (decarboxylating) | L-Arogenate <=> L-Phenylalanine + H2O + CO2 | Phenylalanine, tyrosine and tryptophan biosynthesis | 4.2.1.51        4.2.1.91
0.124 | 0.096 | 0.152 | R00848 | sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase | sn-Glycerol 3-phosphate + FAD <=> Glycerone phosphate + FADH2 | Glycerophospholipid metabolism | 1.1.99.5
0.123 | 0.245 | 0.001 | R00482 | L-Aspartate:ammonia ligase (ADP-forming) | ATP + L-Aspartate + NH3 <=> ADP + Orthophosphate + L-Asparagine | Nitrogen metabolism | 6.3.1.4
0.123 | 0.242 | 0.004 | R01776 | Acetyl-CoA:L-homoserine O-acetyltransferase | Acetyl-CoA + L-Homoserine <=> CoA + O-Acetyl-L-homoserine | Methionine metabolism,[NAME] metabolism | 2.3.1.31
0.1225 | 0.239 | 0.006 | R00149 | Carbon-dioxide:ammonia ligase (ADP-forming,carbamate-phosphorylating) | 2 ATP + NH3 + CO2 + H2O <=> 2 ADP + Orthophosphate + Carbamoyl phosphate | Urea cycle and metabolism of amino groups,Glutamate metabolism,Arginine and proline metabolism,Nitrogen metabolism | 6.3.4.16
0.122 | 0.216 | 0.028 | R00943 | Formate:tetrahydrofolate ligase (ADP-forming) | Tetrahydrofolate + Formate + ATP <=> ADP + Orthophosphate + 10-Formyltetrahydrofolate | Glyoxylate and dicarboxylate metabolism,One carbon pool by folate | 3.5.4.9         6.3.4.3
0.121 | 0.178 | 0.064 | EC563 | nucleoside-diphosphate kinase (ATP:UDP) | [c]atp + udp <==> adp + utp | Nucleotide Salvage Pathways | EC-2.7.4.6
0.121 | 0.166 | 0.076 | EC562 | nucleoside-diphosphate kinase (ATP:GDP) | [c]atp + gdp <==> adp + gtp | Nucleotide Salvage Pathways | EC-2.7.4.6
0.1205 | 0.1 | 0.141 | R06836 | Ribose 1,5-biphosphokinase | D-Ribose 1,5-bisphosphate + ATP <=> 5-Phospho-alpha-D-ribose 1-diphosphate + ADP | Pentose phosphate pathway
0.1205 | 0.1 | 0.141 | R01050 | ATP:D-ribose-5-phosphate 1-phosphotransferase | ATP + D-Ribose 5-phosphate <=> ADP + D-Ribose 1,5-bisphosphate |  | 2.7.1.18
0.1205 | 0.004 | 0.237 | EC603 | purine-nucleoside phosphorylase ([NAME]) | [c]gsn + pi <==> gua + r1p | Nucleotide Salvage Pathways | EC-2.4.2.1
0.12 | 0.232 | 0.008 | R01730 | Prephenate:NADP+ oxidoreductase(decarboxylating) | Prephenate + NADP+ <=> 3-(4-Hydroxyphenyl)pyruvate + CO2 + NADPH + H+ | Phenylalanine, tyrosine and tryptophan biosynthesis | 1.3.1.13        1.3.1.43
0.1195 | 0.086 | 0.153 | R00085 | ATP diphosphohydrolase | ATP + 2 H2O <=> AMP + 2 Orthophosphate |  | 3.6.1.5
0.119 | 0.146 | 0.092 | R07164 | L-aspartate:NAD+ oxidoreductase (deaminating) | L-Aspartate + H2O + NAD+ <=> Oxaloacetate + NH3 + NADH + H+ |  | 1.4.1.21
0.119 | 0.102 | 0.136 | R01568 | ADP:thymidine 5\'-phosphotransferase | ADP + Thymidine <=> AMP + dTMP |  | 2.7.1.118
0.1185 | 0.182 | 0.055 | EC564 | nucleoside-diphosphate kinase (ATP:CDP) | [c]atp + cdp <==> adp + ctp | Nucleotide Salvage Pathways | EC-2.7.4.6
0.1175 | 0.186 | 0.049 | R00695 | L-Aspartate:phenylpyruvate aminotransferase | L-Aspartate + Phenylpyruvate <=> Oxaloacetate + L-Phenylalanine |  | 2.6.1.70
0.117 | 0.135 | 0.099 | R00208 | Phosphoenolpyruvate phosphohydrolase | Phosphoenolpyruvate + H2O <=> Pyruvate + Orthophosphate |  | 3.1.3.60
0.117 | 0.127 | 0.107 | R00206 | ATP:pyruvate,orthophosphate phosphotransferase | ATP + Pyruvate + Orthophosphate <=> AMP + Phosphoenolpyruvate + Pyrophosphate | Pyruvate metabolism,Carbon fixation | 2.7.9.1
0.1165 | 0.197 | 0.036 | R00740 | 3-Oxopropanoate:NADP+ oxidoreductase (decarboxylating, CoA-acetylating) | 3-Oxopropanoate + CoA + NADP+ <=> Malonyl-CoA + NADPH | Propanoate metabolism | 1.2.1.18
0.1165 | 0.117 | 0.116 | R01469 | Ethanolamine:oxygen oxidoreductase (deaminating) | Ethanolamine + H2O + Oxygen <=> Glycolaldehyde + NH3 + H2O2 |  | 1.4.3.8
0.116 | 0.027 | 0.205 | EC029 | phosphopentomutase | [c]r1p <==> r5p | Alternate Carbon Metabolism | EC-5.4.2.7
0.1145 | 0.141 | 0.088 | R07165 | L-aspartate:NADP+ oxidoreductase (deaminating) | L-Aspartate + H2O + NADP+ <=> Oxaloacetate + NH3 + NADPH + H+ |  | 1.4.1.21
0.1145 | 0.051 | 0.178 | R01827 | Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase | D-Sedoheptulose 7-phosphate + (2R)-2-Hydroxy-3-(phosphonooxy)-propanal <=> D-Erythrose 4-phosphate + D-Fructose 6-phosphate | Pentose phosphate pathway | 2.2.1.2
0.1135 | 0.041 | 0.186 | R00551 | L-Arginine amidinohydrolase | L-Arginine + H2O <=> L-Ornithine + Urea | Urea cycle and metabolism of amino groups,Arginine and proline metabolism | 3.5.3.1
0.113 | 0.222 | 0.004 | EC430 | methylenetetrahydrofolate dehydrogenase (NADP) | [c]mlthf + nadp <==> h + methf + nadph | Folate Metabolism | EC-1.5.1.5
0.112 | 0.104 | 0.12 | R01138 | dATP:pyruvate O2-phosphotransferase | dATP + Pyruvate <=> dADP + Phosphoenolpyruvate | Purine metabolism | 2.7.1.40
0.11 | 0.199 | 0.021 | R05861 | D-alanine:oxygen oxidoreductase (deaminating) | D-Alanine + H2O + Oxygen <=> Pyruvate + NH3 + H2O2 |  | 1.4.3.3         1.4.3.19
0.109 | 0.218 | 0 | [NAME] | L-Isoleucine:NAD+ oxidoreductase(deaminating) | L-Isoleucine + NAD+ + H2O <=> (S)-3-Methyl-2-oxopentanoic acid + NH3 + NADH + H+ | [NAME], leucine and isoleucine biosynthesis | 1.4.1.9
0.1065 | 0.107 | 0.106 | R00849 | sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase | sn-Glycerol 3-phosphate + Acceptor <=> Glycerone phosphate + Reduced acceptor |  | 1.1.99.4        1.1.99.5
0.106 | 0.101 | 0.111 | R00842 | sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase | sn-Glycerol 3-phosphate + NAD+ <=> Glycerone phosphate + NADH + H+ | Glycerophospholipid metabolism | 1.1.1.8         1.1.1.94
0.106 | 0.1 | 0.112 | R00834 | D-Sorbitol 6-phosphate:NADP+ 1-oxidoreductase | Sorbitol 6-phosphate + NADP+ <=> D-Glucose 6-phosphate + NADPH + H+ |  | 1.1.1.200
0.1055 | 0.104 | 0.107 | R00846 | sn-Glycerol-3-phosphate:oxygen 2-oxidoreductase | sn-Glycerol 3-phosphate + Oxygen <=> Glycerone phosphate + H2O2 | Glycerophospholipid metabolism | 1.1.3.21
0.105 | 0.152 | 0.058 | R01517 | GTP:3-phospho-D-glycerate 1-phosphotransferase | GTP + 3-Phospho-D-glycerate <=> GDP + 3-Phospho-D-glyceroyl phosphate |  | 2.7.2.10
0.104 | 0.198 | 0.01 | [NAME] | L-arogenate:NAD+ oxidoreductase | L-Arogenate + NADP+ <=> L-Tyrosine + CO2 + NADPH | Phenylalanine, tyrosine and tryptophan biosynthesis | 1.3.1.43        1.3.1.78        1.3.1.79
0.104 | 0.061 | 0.147 | R00959 | alpha-D-Glucose 1-phosphate 1,6-phosphomutase | D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate | Glycolysis / Gluconeogenesis,Galactose metabolism,Starch and sucrose metabolism,Streptomycin biosynthesis | 5.4.2.2         5.4.2.5
0.1035 | 0.162 | 0.045 | R07159 | D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase | (2R)-2-Hydroxy-3-(phosphonooxy)-propanal + H2O + 2 Oxidized ferredoxin <=> 3-Phospho-D-glycerate + 2 H+ + 2 Reduced ferredoxin |  | 1.2.7.6
0.1025 | 0.156 | 0.049 | R00373 | Glycine:oxaloacetate aminotransferase | Glycine + Oxaloacetate <=> Glyoxylate + L-Aspartate |  | 2.6.1.35
0.1025 | 0.059 | 0.146 | R00878 | alpha-D-Glucose ketol-isomerase | alpha-D-Glucose <=> D-Fructose | Fructose and mannose metabolism | 5.3.1.5
0.102 | 0.204 | 0 | [NAME] | O-Succinyl-L-homoserine succinate-lyase (adding cysteine) | O-Succinyl-L-homoserine + H2O <=> 2-Oxobutanoate + Succinate + NH3 | Methionine metabolism | 2.5.1.48
0.101 | 0.197 | 0.005 | EC142 | Isocitrate lyase | [c]icit --> glx + succ | Anaplerotic reactions | EC-4.1.3.1
0.1005 | 0.201 | 0 | R04326 |  | 5\'-Phosphoribosylglycinamide + 5,10-Methenyltetrahydrofolate + H2O <=> 5\'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolate | One carbon pool by folate | 2.1.2.2
0.1 | 0.036 | 0.164 | R00210 | Pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating) | Pyruvate + CoA + NADP+ <=> Acetyl-CoA + CO2 + NADPH | Glycolysis / Gluconeogenesis,[NAME] and aspartate metabolism,Pyruvate metabolism | 1.2.1.51        1.2.4.1         1.8.1.4         2.3.1.12
0.0995 | 0.199 | 0 | R04336 |  | L-2-Amino-6-oxoheptanedioate <=> 2,3,4,5-Tetrahydrodipicolinate + H2O | Lysine biosynthesis
0.0995 | 0.199 | 0 | R02755 | meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating) | [NAME] H2O <=> L-2-Amino-6-oxoheptanedioate + NH3 + NADPH + H+ | Lysine biosynthesis | 1.4.1.16
0.0995 | 0.04 | 0.159 | R00211 | Glyoxylate:oxygen oxidoreductase | Pyruvate + CoA + Oxygen <=> H2O2 + Acetyl-CoA + CO2 | Pyruvate metabolism | 1.2.3.6
0.099 | 0.1 | 0.098 | R02415 | Shikimate:pyrroloquinoline-quinone 5-oxidoreductase | Shikimate + PQQ <=> 3-Dehydroshikimate + PQQH2 | Phenylalanine, tyrosine and tryptophan biosynthesis | 1.1.99.25
0.099 | 0.042 | 0.156 | [NAME] | Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase | D-Sedoheptulose 7-phosphate + (2R)-2-Hydroxy-3-(phosphonooxy)-propanal <=> D-Ribose 5-phosphate + D-Xylulose 5-phosphate | Pentose phosphate pathway,Carbon fixation | 2.2.1.1
0.099 | 0.01 | 0.188 | EC585 | pyrimidine-nucleoside phosphorylase (uracil) | [c]pi + uri <==> r1p + ura | Nucleotide Salvage Pathways | EC-2.4.2.2
0.0985 | 0.018 | 0.179 | R01128 | 5\'-Inosinate phosphoribohydrolase | IMP + H2O <=> Hypoxanthine + D-Ribose 5-phosphate | Purine metabolism | 3.2.2.12
0.098 | 0.191 | 0.005 | [NAME] | O-Acetyl-L-homoserine acetate-lyase (adding methanethiol) | O-Acetyl-L-homoserine + Hydrogen sulfide <=> L-Homocysteine + Acetate | Methionine metabolism | 2.5.1.49
0.098 | 0.191 | 0.005 | EC008 | aspartate transaminase | [c]akg + asp-L <==> glu-L + oaa | Alanine and aspartate metabolism | EC-2.6.1.1
0.096 | 0.057 | 0.135 | R01526 | ATP:D-ribulose 5-phosphotransferase | ATP + D-Ribulose <=> ADP + D-Ribulose 5-phosphate | Pentose and glucuronate interconversions | 2.7.1.16        2.7.1.47
0.0955 | 0.19 | 0.001 | R02282 | N2-Acetyl-L-ornithine:L-glutamate N-acetyltransferase | N-Acetylornithine + L-Glutamate <=> L-Ornithine + N-Acetyl-L-glutamate | Urea cycle and metabolism of amino groups | 2.3.1.35
0.0955 | 0.19 | 0.001 | R00858 | hydrogen-sulfide:NADP+ oxidoreductase | Hydrogen sulfide + 3 NADP+ + 3 H2O <=> Sulfite + 3 NADPH + 3 H+ | Sulfur metabolism | 1.8.1.2
0.0955 | 0.048 | 0.143 | R00317 | Acetyl phosphate phosphohydrolase | Acetyl phosphate + H2O <=> Acetate + Orthophosphate | Pyruvate metabolism | 3.6.1.7
0.095 | 0.182 | 0.008 | EC453 | glyceraldehyde-3-phosphate dehydrogenase | [c]g3p + nad + pi <==> 13dpg + h + nadh | Glycolysis/Gluconeogenesis | EC-1.2.1.12
0.095 | 0.172 | 0.018 | R01218 | 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase | 5,10-Methylenetetrahydrofolate + NAD+ <=> 5,10-Methenyltetrahydrofolate + NADH + H+ | One carbon pool by folate | 1.5.1.15
0.0945 | 0.098 | 0.091 | R01010 | Glycerone phosphate phosphohydrolase (alkaline optimum) | Glycerone phosphate + H2O <=> Glycerone + Orthophosphate |  | 3.1.3.1
0.094 | 0.114 | 0.074 | EC279 | 2-Oxogluterate dehydrogenase | [c]akg + coa + nad --> co2 + nadh + succoa | Citrate Cycle (TCA) | EC-Undetermined
0.0935 | 0.186 | 0.001 | R02199 | L-Isoleucine:2-oxoglutarate aminotransferase | L-Isoleucine + 2-Oxoglutarate <=> (S)-3-Methyl-2-oxopentanoic acid + L-Glutamate | [NAME], leucine and isoleucine biosynthesis | 2.6.1.42
0.0915 | 0.101 | 0.082 | EC541 | dCTP deaminase | [c]dctp + h + h2o --> dutp + nh4 | Nucleotide Salvage Pathways | EC-3.5.4.13
0.091 | 0.181 | 0.001 | EC926 | valine transaminase | [c]akg + val-L <==> 3mob + glu-L | [NAME], leucine, and isoleucine metabolism | EC-2.6.1.42
0.0905 | 0.153 | 0.028 | R05717 | AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5\'-phosphosulfate-forming) | AMP + Sulfite + Oxidized glutathione <=> Adenylylsulfate + 2 Glutathione |  | 1.8.4.9
0.0905 | 0.052 | 0.129 | R02599 | CTP:N-acylneuraminate cytidylyltransferase | CTP + N-Acylneuraminate <=> Pyrophosphate + CMP-N-acylneuraminate |  | 2.7.7.43
0.0905 | 0.052 | 0.129 | R02598 | CMP-N-acylneuraminate N-acylneuraminohydrolase | CMP-N-acylneuraminate + H2O <=> CMP + N-Acylneuraminate |  | 3.1.4.40
0.0895 | 0.179 | 0 | R01216 | 2-Hydroxy-2-isopropylbutanedioate formaldehyde-lyase | 2-Dehydropantoate <=> 3-Methyl-2-oxobutanoic acid + Formaldehyde |  | 4.1.2.12
0.0895 | 0.063 | 0.116 | R05804 | ADP:D-glucose 6-phosphotransferase | ADP + D-Glucose <=> AMP + D-Glucose 6-phosphate |  | 2.7.1.147
0.0895 | 0.012 | 0.167 | R01571 | ATP:thymidine 5\'-phosphotransferase | AMP + Thymidine <=> Adenosine + dTMP |  | 2.7.1.114
0.089 | 0.178 | 0 | EC011 | alanine racemase (irreversible) | [c]ala-L --> ala-D | Alanine and aspartate metabolism | EC-5.1.1.1
0.0875 | 0.173 | 0.002 | R00861 | Hydrogen-sulfide:(acceptor) oxidoreductase | Hydrogen sulfide + Acceptor + 3 H2O <=> Sulfite + Reduced acceptor | Sulfur metabolism | 1.8.99.1
0.0875 | 0.151 | 0.024 | R00688 | L-phenylalanine:NAD+ oxidoreductase (deaminating) | L-Phenylalanine + H2O + NAD+ <=> Phenylpyruvate + NH3 + NADH + H+ | Phenylalanine metabolism,[NAME], tyrosine and tryptophan biosynthesis | 1.4.1.20
0.087 | 0.047 | 0.127 | R01196 |  | Reduced ferredoxin + Acetyl-CoA + CO2 <=> Oxidized ferredoxin + Pyruvate + CoA | Pyruvate metabolism,Butanoate metabolism,Reductive carboxylate cycle (CO2 fixation) | 1.2.7.1
0.0865 | 0.173 | 0 | EC426 | cysteine synthase | [c]acser + h2s --> ac + cys-L + h | Cysteine Metabolism | EC-4.2.99.8
0.0855 | 0.159 | 0.012 | R01726 |  | Nicotinate + CO2 <=> Pyridine-2,3-dicarboxylate | Alkaloid biosynthesis II
0.0855 | 0.142 | 0.029 | R07276 | L-arogenate:2-oxoglutarate aminotransferase | L-Arogenate + 2-Oxoglutarate <=> Prephenate + L-Glutamate |  | 2.6.1.79
0.085 | 0.142 | 0.028 | R01731 | L-Aspartate:2-oxoglutarate aminotransferase | Oxaloacetate + L-Arogenate <=> L-Aspartate + Prephenate | Phenylalanine, tyrosine and tryptophan biosynthesis | 2.6.1.57        2.6.1.78
0.0845 | 0.141 | 0.028 | R07407 | L-aspartate:NADP+ oxidoreductase (deaminating) | L-Aspartate + NADP+ <=> Iminoaspartate + NADPH + H+ | Nicotinate and nicotinamide metabolism | 1.4.1.21
0.0845 | 0.132 | 0.037 | R01063 | D-Glyceraldehyde-3-phosphate:NADP+ oxidoreductase(phosphorylating) | (2R)-2-Hydroxy-3-(phosphonooxy)-propanal + Orthophosphate + NADP+ <=> 3-Phospho-D-glyceroyl phosphate + NADPH + H+ | Glycolysis / Gluconeogenesis,Carbon fixation | 1.2.1.12        1.2.1.13        1.2.1.59
0.0845 | 0.068 | 0.101 | R02236 | Dihydrofolate:NADP+ oxidoreductase | Dihydrofolate + NADP+ <=> Folate + NADPH + H+ | One carbon pool by folate,Folate biosynthesis | 1.5.1.3
0.0835 | 0.117 | 0.05 | R00604 | Formaldehyde:NAD+ oxidoreductase | Formaldehyde + NAD+ + H2O <=> Formate + NADH + H+ | Urea cycle and metabolism of amino groups,Methane metabolism | 1.2.1.46
0.0835 | 0.079 | 0.088 | R01139 | dATP:D-hexose 6-phosphotransferase | dATP + D-Glucose <=> dADP + D-Glucose 6-phosphate |  | 2.7.1.1
0.0835 | 0.034 | 0.133 | R02405 | Itaconate:CoA ligase (IDP-forming) | GTP + Itaconate + CoA <=> GDP + Orthophosphate + Itaconyl-CoA |  | 6.2.1.4
0.083 | 0.081 | 0.085 | R00850 | sn-Glycerol-3-phosphate:D-glucose 6-phosphotransferase | sn-Glycerol 3-phosphate + D-Glucose <=> Glycerol + D-Glucose 6-phosphate |  | 2.7.1.142
0.083 | 0.064 | 0.102 | R00514 | CDP diphosphohydrolase | CDP + H2O <=> CMP + Orthophosphate | Pyrimidine metabolism | 3.6.1.5
0.0825 | 0.165 | 0 | EC423 | serine O-acetyltransferase | [c]accoa + ser-L <==> acser + coa | Cysteine Metabolism | EC-2.3.1.30
0.0825 | 0.064 | 0.101 | R01140 | dATP:D-hexose 6-phosphotransferase | dATP + D-Fructose <=> dADP + D-Fructose 6-phosphate |  | 2.7.1.1
0.0825 | 0.056 | 0.109 | R01577 | D-Arabinose ketol-isomerase | D-Arabinose <=> D-Ribulose |  | 5.3.1.3
0.081 | 0.076 | 0.086 | [NAME] | Succinate:CoA ligase (GDP-forming) | ITP + Succinate + CoA <=> IDP + Orthophosphate + Succinyl-CoA | Citrate cycle (TCA cycle) | 6.2.1.4
0.0805 | 0.161 | 0 | R01283 | L-Homocysteine hydrogen-sulfide-lyase (deaminating) | L-Homocysteine + H2O <=> Hydrogen sulfide + NH3 + 2-Oxobutanoate | Nitrogen metabolism,[NAME] metabolism | 4.4.1.2
0.0805 | 0.144 | 0.017 | EC648 | 2-dehydro-3-deoxy-phosphogluconate aldolase | [c]2ddg6p --> g3p + pyr | Pentose Phosphate Cycle | EC-4.1.2.14
0.0805 | 0.135 | 0.026 | R00907 | L-Alanine:3-oxopropanoate aminotransferase | L-Alanine + 3-Oxopropanoate <=> Pyruvate + beta-Alanine | Alanine and aspartate metabolism,beta-Alanine metabolism,Propanoate metabolism | 2.6.1.18
0.0805 | 0.064 | 0.097 | R00940 | 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase | Tetrahydrofolate + NADP+ <=> Folate + NADPH | Folate biosynthesis | 1.5.1.3
0.08 | 0.16 | 0 | R01434 | L-Valine:NAD+ oxidoreductase(deaminating) | L-Valine + H2O + NAD+ <=> 3-Methyl-2-oxobutanoic acid + NH3 + NADH | [NAME], leucine and isoleucine biosynthesis | 1.4.1.9
0.08 | 0.032 | 0.128 | R01117 | CTP:N-acylneuraminate cytidylyltransferase | CTP + N-Acetylneuraminate <=> Pyrophosphate + CMP-N-acetylneuraminate | Aminosugars metabolism | 2.7.7.43
0.0795 | 0.135 | 0.024 | EC054 | glycerol-3-phosphate dehydrogenase (NADP) | [c]glyc3p + nadp <==> dhap + h + nadph | Alternate Carbon Metabolism | EC-1.1.1.94
0.0795 | 0.119 | 0.04 | EC709 | phosphotransacetylase | [c]accoa + pi <==> actp + coa | Pyruvate metabolism | EC-2.3.1.8
0.0795 | 0.069 | 0.09 | [NAME] | 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase | Tetrahydrofolate + NAD+ <=> Folate + NADH | Folate biosynthesis | 1.5.1.3
0.0795 | 0.067 | 0.092 | [NAME] | Dihydrofolate:NAD+ oxidoreductase | Dihydrofolate + NAD+ <=> Folate + NADH + H+ | Folate biosynthesis | 1.5.1.3
0.0785 | 0.157 | 0 | EC009 | Valine-pyruvate aminotransferase | [c]3mob + ala-L --> pyr + val-L | Alanine and aspartate metabolism | EC-2.6.1.66
0.0785 | 0.146 | 0.011 | R00014 | 2-(alpha-Hydroxyethyl)thiamine diphosphate pyruvate-lyase (carboxylating) | 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2 <=> Thiamin diphosphate + Pyruvate | Glycolysis / Gluconeogenesis,[NAME], leucine and isoleucine biosynthesis,Butanoate metabolism | 1.2.4.1         2.2.1.6         4.1.1.1
0.0775 | 0.145 | 0.01 | R00134 | Formate:NADP+ oxidoreductase | Formate + NADP+ <=> CO2 + NADPH | Methane metabolism | 1.2.1.43
0.0775 | 0.106 | 0.049 | R00224 | Pyruvate carboxy-lyase | Pyruvate <=> Acetaldehyde + CO2 |  | 4.1.1.1
0.0775 | 0.095 | 0.06 | R01713 | Pyridoxamine:oxaloacetate aminotransferase | Pyridoxamine + Oxaloacetate <=> Pyridoxal + L-Aspartate | [NAME] metabolism | 2.6.1.31
0.077 | 0.147 | 0.007 | R01869 | (S)-Dihydroorotate:(acceptor) oxidoreductase; (S)-Dihydroorotate:NAD+ oxidoreductase | (S)-Dihydroorotate + NAD+ <=> Orotate + H+ + NADH | Pyrimidine metabolism | 1.3.1.14        1.3.99.11
0.077 | 0.13 | 0.024 | R00692 | L-Phenylalanine(L-histidine):pyruvate aminotransferase | L-Phenylalanine + Pyruvate <=> Phenylpyruvate + L-Alanine |  | 2.6.1.58
0.077 | 0.061 | 0.093 | R02568 | D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase | D-Fructose 1-phosphate <=> Glycerone phosphate + D-Glyceraldehyde | Fructose and mannose metabolism | 4.1.2.13
0.0765 | 0.146 | 0.007 | R01866 | (S)-dihydroorotate:NADP+ oxidoreductase | (S)-Dihydroorotate + NADP+ <=> Orotate + NADPH + H+ |  | 1.3.1.15
0.0765 | 0.127 | 0.026 | R00908 | 3-Aminopropanoate:2-oxoglutarate aminotransferase | beta-Alanine + 2-Oxoglutarate <=> 3-Oxopropanoate + L-Glutamate | Alanine and aspartate metabolism,beta-Alanine metabolism,Propanoate metabolism | 2.6.1.19        2.6.1.55
0.0765 | 0.068 | 0.085 | R01724 | Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase | Nicotinate D-ribonucleotide + Pyrophosphate <=> Nicotinate + 5-Phospho-alpha-D-ribose 1-diphosphate | Nicotinate and nicotinamide metabolism | 2.4.2.11
0.076 | 0.105 | 0.047 | R01343 | L-Ornithine:2-oxo-acid aminotransferase | L-Ornithine + 2-Oxo acid <=> L-Glutamate 5-semialdehyde + L-Amino acid |  | 2.6.1.13
0.076 | 0.028 | 0.124 | EC549 | xanthine phosphoribosyltransferase | [c]prpp + xan --> ppi + xmp | Nucleotide Salvage Pathways | EC-2.4.2.22
0.0755 | 0.134 | 0.017 | EC462 | phosphoenolpyruvate synthase | [c]atp + h2o + pyr --> amp + (2) h + pep + pi | Glycolysis/Gluconeogenesis | [NAME]
0.0755 | 0.058 | 0.093 | R00021 | L-Glutamate:ferredoxin oxidoreductase (transaminating) | 2 L-Glutamate + 2 Oxidized ferredoxin <=> L-Glutamine + 2-Oxoglutarate + 2 Reduced ferredoxin | Nitrogen metabolism | 1.4.7.1
0.075 | 0.15 | 0 | EC002 | L-alanine transaminase | [c]akg + ala-L <==> glu-L + pyr | Alanine and aspartate metabolism | EC-2.6.1.2
0.0745 | 0.068 | 0.081 | R03237 | CTP:D-Tagatose 6-phosphate 1-phosphotransferase | CTP + D-Tagatose 6-phosphate <=> CDP + D-Tagatose 1,6-bisphosphate | Galactose metabolism | 2.7.1.11
0.074 | 0.145 | 0.003 | EC908 | phenylalanine transaminase | [c]akg + phe-L <==> glu-L + phpyr | Tyrosine, Tryptophan, and [NAME] | EC-2.6.1.58
0.074 | 0.12 | 0.028 | EC449 | enolase | [c]2pg <==> h2o + pep | Glycolysis/Gluconeogenesis | EC-4.2.1.11
0.0735 | 0.138 | 0.009 | EC368 | L-aspartate oxidase | [c]asp-L + fum --> iasp + succ | Cofactor and Prosthetic Group Biosynthesis
0.0735 | 0.002 | 0.145 | EC659 | GMP reductase | [c]gmp + (2) h + nadph --> imp + nadp + nh4 | Purine and Pyrimidine Biosynthesis | EC-1.6.6.8
0.073 | 0.146 | 0 | R01795 | L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) | Tetrahydrobiopterin + L-Phenylalanine + Oxygen <=> Dihydrobiopterin + L-Tyrosine + H2O | Phenylalanine, tyrosine and tryptophan biosynthesis | 1.14.16.1
0.0725 | 0.061 | 0.084 | R00337 | GDPglucose glucohydrolase | GDP-glucose + H2O <=> GDP + D-Glucose |  | 3.2.1.42
0.0725 | 0.06 | 0.085 | R01233 | GDPglucose sugarphosphohydrolase | GDP-glucose + H2O <=> GMP + D-Glucose 1-phosphate | Starch and sucrose metabolism | 3.6.1.21
0.072 | 0.063 | 0.081 | R01070 | beta-D-Fructose 1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase | beta-D-Fructose 1,6-bisphosphate <=> Glycerone phosphate + (2R)-2-Hydroxy-3-(phosphonooxy)-propanal | Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism,Carbon fixation | 4.1.2.13
0.0715 | 0.028 | 0.115 | R01081 | D-Ribose ketol-isomerase | D-Ribose <=> D-Ribulose |  | 5.3.1.20
0.071 | 0.09 | 0.052 | EC205 | Ethanolamine ammonia-lyase | [c]etha --> acald + nh4 | Cell Envelope Biosynthesis | EC-4.3.1.7
0.071 | 0.076 | 0.066 | R03238 | UTP:D-Tagatose 6-phosphate 1-phosphotransferase | UTP + D-Tagatose 6-phosphate <=> UDP + D-Tagatose 1,6-bisphosphate | Galactose metabolism | 2.7.1.11
0.0705 | 0.136 | 0.005 | R00859 | Hydrogen-sulfide:ferredoxin oxidoreductase | Hydrogen sulfide + 3 Oxidized ferredoxin + 3 H2O <=> Sulfite + 3 Reduced ferredoxin | Sulfur metabolism | 1.8.7.1
0.07 | 0.062 | 0.078 | R01848 | ITP:Sedoheptulose 7-phosphate 1-phosphotransferase | ITP + Sedoheptulose 7-phosphate <=> IDP + Sedoheptulose 1,7-bisphosphate |  | 2.7.1.11
0.07 | 0.033 | 0.107 | R00760 | ATP:D-fructose 6-phosphotransferase | ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate |  | 2.7.1.1         2.7.1.4
0.0695 | 0 | 0.139 | EC295 | nicotinamide-nucleotide amidase | [c]h2o + nmn --> nh4 + nicrnt | Cofactor and Prosthetic Group Biosynthesis | EC-3.5.1.42
0.0685 | 0.035 | 0.102 | R00876 | ITP:D-hexose 6-phosphotransferase | ITP + D-Fructose <=> IDP + D-Fructose 6-phosphate |  | 2.7.1.1
0.068 | 0.081 | 0.055 | R00372 | Glycine:2-oxoglutarate aminotransferase | Glycine + 2-Oxoglutarate <=> Glyoxylate + L-Glutamate | Glycine, serine and threonine metabolism | 2.6.1.4
0.0675 | 0.134 | 0.001 | R00669 | N2-Acetyl-L-ornithine amidohydrolase | N-Acetylornithine + H2O <=> Acetate + L-Ornithine | Urea cycle and metabolism of amino groups | 3.5.1.14        3.5.1.16
0.0675 | 0.133 | 0.002 | R01212 | L-valine:NADP+ oxidoreductase (deaminating) | L-Valine + NADP+ + H2O <=> 3-Methyl-2-oxobutanoic acid + NH3 + NADPH + H+ |  | 1.4.1.8
0.0675 | 0.061 | 0.074 | R00770 | ITP:D-fructose-6-phosphate 1-phosphotransferase | ITP + D-Fructose 6-phosphate <=> IDP + D-Fructose 1,6-bisphosphate |  | 2.7.1.11
0.067 | 0.089 | 0.045 | R00711 | Acetaldehyde:NADP+ oxidoreductase | Acetaldehyde + NADP+ + H2O <=> Acetate + NADPH + H+ | Glycolysis / Gluconeogenesis,Pyruvate metabolism | 1.2.1.3         1.2.1.5
0.0665 | 0.127 | 0.006 | EC369 | L-aspartate oxidase | [c]asp-L + o2 --> h2o2 + iasp | Cofactor and Prosthetic Group Biosynthesis
0.0665 | 0.03 | 0.103 | [NAME] | dCDP nucleotidohydrolase | dCDP + H2O <=> dCMP + Orthophosphate | Pyrimidine metabolism | 3.6.1.12
0.066 | 0.077 | 0.055 | R01710 | Pyridoxamine:oxygen oxidoreductase (deaminating) | Pyridoxamine + H2O + Oxygen <=> Pyridoxal + NH3 + H2O2 | [NAME] metabolism | 1.4.3.5
0.066 | 0.006 | 0.126 | EC524 | adenosine kinase | [c]adn + atp --> adp + amp + h | Nucleotide Salvage Pathways | EC-2.7.1.20
0.0655 | 0.076 | 0.055 | R00686 | L-Phenylalanine racemase (ATP-hydrolysing) | ATP + L-Phenylalanine + H2O <=> AMP + Pyrophosphate + D-Phenylalanine | Phenylalanine metabolism | 5.1.1.11
0.0645 | 0.075 | 0.054 | R01582 | D-Phenylalanine:2-oxoglutarate aminotransferase | D-Phenylalanine + 2-Oxoglutarate <=> Phenylpyruvate + D-Glutamate | Phenylalanine metabolism | 2.6.1.21
0.0645 | 0.068 | 0.061 | R01195 | [NAME]:NADP+ oxidoreductase | Reduced ferredoxin + NADP+ <=> Oxidized ferredoxin + NADPH + H+ |  | 1.18.1.2
0.0645 | 0.066 | 0.063 | R07227 | acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase(N-methylglycine-forming) | Acetyl phosphate + Methylamine + Oxidized thioredoxin <=> Sarcosine + Orthophosphate + Thioredoxin |  | 1.21.4.3
0.064 | 0.128 | 0 | EC676 | dihydoorotic acid dehydrogenase ([NAME]) | [c]dhor-S + q8 --> orot + q8h2 | Purine and Pyrimidine Biosynthesis | EC-1.3.3.1
0.064 | 0.051 | 0.077 | R01843 | ATP:Sedoheptulose 7-phosphate 1-phosphotransferase | ATP + Sedoheptulose 7-phosphate <=> ADP + Sedoheptulose 1,7-bisphosphate |  | 2.7.1.11
0.0635 | 0.036 | 0.091 | [NAME] | D-Glutamine amidohydrolase | D-Glutamine + H2O <=> D-Glutamate + NH3 | D-Glutamine and D-glutamate metabolism,Nitrogen metabolism | 3.5.1.2         3.5.1.35        3.5.1.38
0.0635 | 0.036 | 0.091 | R00579 | L-Glutamine racemase | L-Glutamine <=> D-Glutamine | D-Glutamine and D-glutamate metabolism | 5.1.1.9         5.1.1.10
0.063 | 0.035 | 0.091 | R00243 | L-Glutamate:NAD+ oxidoreductase (deaminating) | L-Glutamate + NAD+ + H2O <=> 2-Oxoglutarate + NH3 + NADH + H+ | Urea cycle and metabolism of amino groups,Glutamate metabolism,Arginine and proline metabolism,D-Glutamine and D-glutamate metabolism,Nitrogen metabolism | 1.4.1.2         1.4.1.3         1.4.1.4
0.0625 | 0.123 | 0.002 | R03217 | O-Acetyl-L-homoserine succinate-lyase (adding cysteine) | O-Acetyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Acetate | Methionine metabolism | 2.5.1.49
0.0625 | 0.116 | 0.009 | R01868 | (S)-Dihydroorotate:(acceptor) oxidoreductase | (S)-Dihydroorotate + Acceptor <=> Orotate + Reduced acceptor |  | 1.3.99.11
0.062 | 0.124 | 0 | R02508 |  | Cystathionine + Succinate <=> O-Succinyl-L-homoserine + L-Cysteine | Sulfur metabolism | 2.5.1.48
0.0615 | 0.092 | 0.031 | R00326 | Acetaldehyde:(acceptor) oxidoreductase | Acetaldehyde + Acceptor + H2O <=> Acetate + Reduced acceptor | Pyruvate metabolism | 1.2.99.6
0.061 | 0.121 | 0.001 | EC421 | adenylyl-sulfate kinase | [c]aps + atp --> adp + h + paps | Cysteine Metabolism | EC-2.7.1.25
0.0605 | 0.108 | 0.013 | EC649 | 6-phosphogluconate dehydratase | [c]6pgc --> 2ddg6p + h2o | Pentose Phosphate Cycle
0.06 | 0.075 | 0.045 | R00400 | L-Alanine:2-oxo-acid aminotransferase | L-Alanine + Oxaloacetate <=> Pyruvate + L-Aspartate | Alanine and aspartate metabolism | 2.6.1.12
0.06 | 0.038 | 0.082 | R02740 | alpha-D-Glucose 6-phosphate ketol-isomerase | alpha-D-Glucose 6-phosphate <=> beta-D-Fructose 6-phosphate | Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Starch and sucrose metabolism | 5.3.1.9
0.0595 | 0.116 | 0.003 | EC366 | L-aspartate oxidase | [c]asp-L + q8 --> iasp + q8h2 | Cofactor and Prosthetic Group Biosynthesis
0.059 | 0.053 | 0.065 | R05875 | Ferredoxin:NAD oxidoreductase | Reduced ferredoxin + NAD+ <=> Oxidized ferredoxin + NADH + H+ | Toluene and xylene degradation | 1.18.1.3
0.059 | 0.017 | 0.101 | EC104 | ribokinase | [c]atp + rib-D --> adp + h + r5p | Alternate Carbon Metabolism | EC-2.7.1.15
0.0585 | 0.116 | 0.001 | EC143 | malate synthase | [c]accoa + glx + h2o --> coa + h + mal-L | Anaplerotic reactions | EC-4.1.3.2
0.058 | 0.073 | 0.043 | R01712 | Pyridoxamine:pyruvate aminotransferase | Pyridoxamine + Pyruvate <=> Pyridoxal + L-Alanine | [NAME] metabolism | 2.6.1.30
0.0575 | 0.043 | 0.072 | R02073 | Pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase | Pyrophosphate + beta-D-Fructose 6-phosphate <=> Orthophosphate + beta-D-Fructose 1,6-bisphosphate | Fructose and mannose metabolism | 2.7.1.90
0.0575 | 0.029 | 0.086 | R00093 | L-glutamate:NAD+ oxidoreductase (transaminating) | 2 L-Glutamate + NAD+ <=> L-Glutamine + 2-Oxoglutarate + NADH + H+ | Glutamate metabolism,Nitrogen metabolism | 1.4.1.14
0.0565 | 0.113 | 0 | EC445 | L-serine deaminase | [c]ser-L --> nh4 + pyr | Glycine and Serine Metabolism | EC-Undetermined
0.056 | 0.058 | 0.054 | R00925 | Propanoate:CoA ligase (AMP-forming) | ATP + Propanoate + CoA <=> AMP + Pyrophosphate + Propanoyl-CoA |  | 6.2.1.17
0.0555 | 0.097 | 0.014 | EC458 | phosphoglycerate mutase | [c]2pg <==> 3pg | Glycolysis/Gluconeogenesis | EC-5.4.2.1
0.0555 | 0.091 | 0.02 | EC525 | adenylate kinase | [c]amp + atp <==> (2) adp | Nucleotide Salvage Pathways | EC-2.7.4.3
0.0555 | 0.045 | 0.066 | R02069 | D-Fructose 1,6-bisphosphate phosphohydrolase | D-Fructose 1,6-bisphosphate + H2O <=> D-Fructose 1-phosphate + Orthophosphate |  | 3.1.3.68
0.054 | 0.108 | 0 | R01290 | L-Serine hydro-lyase (adding homocysteine) | L-Serine + L-Homocysteine <=> L-Cystathionine + H2O | Glycine, serine and threonine metabolism,[NAME] metabolism | 4.2.1.22
0.054 | 0.102 | 0.006 | R01867 | (S)-Dihydroorotate:oxygen oxidoreductase | (S)-Dihydroorotate + Oxygen <=> Orotate + H2O2 | Pyrimidine metabolism | 1.3.3.1         1.3.99.11
0.054 | 0.002 | 0.106 | R01677 | [NAME] ribohydrolase | [NAME] <=> Guanine + D-Ribose | Purine metabolism | 3.2.2.1         3.2.2.8
0.0535 | 0.104 | 0.003 | R00584 | Pyrophosphate:L-serine O-phosphotransferase | Pyrophosphate + L-Serine <=> Orthophosphate + O-Phospho-L-serine |  | 2.7.1.80
0.0535 | 0.08 | 0.027 | EC111 | sorbitol-6-phosphate dehydrogenase | [c]nad + sbt6p <==> f6p + h + nadh | Alternate Carbon Metabolism | EC-1.1.1.140
0.0535 | 0.068 | 0.039 | R00365 | glycine:NAD+ oxidoreductase (deaminating) | Glycine + H2O + NAD+ <=> Glyoxylate + NH3 + NADH + H+ |  | 1.4.1.10
0.0525 | 0.065 | 0.04 | R01440 | D-Xylulose-5-phosphate:formaldehyde glycolaldehydetransferase | D-Xylulose 5-phosphate + Formaldehyde <=> (2R)-2-Hydroxy-3-(phosphonooxy)-propanal + Glycerone | Methane metabolism | 2.2.1.3
0.0515 | 0.098 | 0.005 | EC163 | N-acetylornithine deacetylase | [c]acg5sa + h2o --> ac + glu5sa | Arginine and Proline Metabolism
0.0515 | 0.095 | 0.008 | EC461 | phosphoglycerate kinase | [c]3pg + atp <==> 13dpg + adp | Glycolysis/Gluconeogenesis | EC-2.7.2.3
0.0515 | 0.076 | 0.027 | EC390 | nicotinic acid mononucleotide pyrophosphorylase | [c]atp + h2o + nac + prpp --> adp + nicrnt + pi + ppi | Cofactor and Prosthetic Group Biosynthesis
0.0515 | 0.036 | 0.067 | R01468 | ATP:ethanolamine O-phosphotransferase | ATP + Ethanolamine <=> ADP + Ethanolamine phosphate | Glycerophospholipid metabolism | 2.7.1.82
0.051 | 0.06 | 0.042 | R01019 |  | PQQ + Acetaldehyde + H2O <=> PQQH2 + Acetate | Pyruvate metabolism | 1.2.99.3
0.0505 | 0.09 | 0.011 | EC527 | adentylate [NAME] (ITP) | [c]amp + itp <==> adp + idp | Nucleotide Salvage Pathways
0.0505 | 0.047 | 0.054 | EC191 | ornithine transaminase | [c]akg + orn --> glu-L + glu5sa | Arginine and Proline Metabolism | EC-2.6.1.13
0.05 | 0.069 | 0.031 | EC554 | Nucleoside triphosphate pyrophosphorylase (dctp) | [c]dctp + h2o --> dcmp + h + ppi | Nucleotide Salvage Pathways
0.05 | 0.046 | 0.054 | R01044 | Pyrophosphate:glycerol 1-phosphotransferase | Pyrophosphate + Glycerol <=> Orthophosphate + Glycerol 1-phosphate |  | 2.7.1.79
0.05 | 0.038 | 0.062 | R00841 | Glycerol-3-phosphate phosphohydrolase | sn-Glycerol 3-phosphate + H2O <=> Glycerol + Orthophosphate | Glycerolipid metabolism | 3.1.3.21
0.049 | 0.095 | 0.003 | R00718 |  | H+ + 3\'-Phosphoadenylyl sulfate + Reduced acceptor <=> Sulfite + Acceptor + ADP
0.049 | 0.035 | 0.063 | R03239 | ITP:D-Tagatose 6-phosphate 1-phosphotransferase | ITP + D-Tagatose 6-phosphate <=> IDP + D-Tagatose 1,6-bisphosphate | Galactose metabolism | 2.7.1.11
0.0485 | 0.056 | 0.041 | EC044 | UDPglucose--hexose-1-phosphate uridylyltransferase | [[NAME] + udpg <==> g1p + udpgal | Alternate Carbon Metabolism | EC-2.7.7.12
0.0485 | 0.043 | 0.054 | R04386 | Acetyl-CoA:carbon-dioxide ligase (ADP-forming) | Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein <=> Malonyl-CoA + Holo-[carboxylase] | Fatty acid biosynthesis | 6.4.1.2
0.0485 | 0.043 | 0.054 | R04385 | Biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) | ATP + Holo-[carboxylase] + HCO3- <=> ADP + Orthophosphate + Carboxybiotin-carboxyl-carrier protein | Fatty acid biosynthesis | 6.3.4.14
0.0485 | 0.03 | 0.067 | R00229 | Acetate:CoA ligase (ADP-forming) | ATP + Acetate + CoA <=> ADP + Acetyl-CoA + Orthophosphate | Pyruvate metabolism | 6.2.1.13
0.0485 | 0.028 | 0.069 | R00947 | D-Glucose-1-phosphate phosphohydrolase | D-Glucose 1-phosphate + H2O <=> alpha-D-Glucose + Orthophosphate | Glycolysis / Gluconeogenesis | 3.1.3.10
0.0485 | 0.021 | 0.076 | R00250 | L-Glutamate:oxygen oxidoreductase (deaminating) | L-Glutamate + Oxygen + H2O <=> 2-Oxoglutarate + NH3 + H2O2 |  | 1.4.3.11
0.048 | 0.083 | 0.013 | EC704 | acetate kinase | [c]ac + atp <==> actp + adp | Pyruvate metabolism | EC-2.7.2.1
0.048 | 0.053 | 0.043 | EC647 | 6-phosphogluconolactonase | [c]6pgl + h2o --> 6pgc + h | Pentose Phosphate Cycle | EC-3.1.1.31
0.048 | 0.035 | 0.061 | R02628 | Phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase | Phosphoenolpyruvate + Protein histidine <=> Pyruvate + Protein N(pi)-phospho-L-histidine |  | 2.7.3.9
0.048 | 0.03 | 0.066 | R02868 | dATP:D-hexose 6-phosphotransferase | dATP + D-Sorbitol <=> dADP + Sorbitol 6-phosphate |  | 2.7.1.1
0.047 | 0.094 | 0 | [NAME] | (R)-2,3-Dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) | (R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid + NADPH | [NAME], leucine and isoleucine biosynthesis | 1.1.1.86
0.047 | 0.022 | 0.072 | R07364 | 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming) | 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one + Oxygen <=> 4-Methylthio-2-oxobutanoic acid + Formate | Methionine metabolism | 1.13.11.54
0.0465 | 0.052 | 0.041 | [NAME] | UTP:alpha-D-hexose-1-phosphate uridylyltransferase | UTP + alpha-D-Galactose 1-phosphate <=> Pyrophosphate + UDP-D-galactose | Galactose metabolism,Nucleotide sugars metabolism | 2.7.7.10
0.0465 | 0.033 | 0.06 | [NAME] | Acetate:CoA ligase (AMP-forming) | ATP + Acetate <=> Pyrophosphate + Acetyl adenylate | Pyruvate metabolism | 6.2.1.1
0.0465 | 0.033 | 0.06 | R00236 | Acetyl adenylate:CoA ligase (AMP-forming) | Acetyl adenylate + CoA <=> AMP + Acetyl-CoA | Pyruvate metabolism | 6.2.1.1
0.046 | 0.036 | 0.056 | R00207 | Pyruvate:oxygen 2-oxidoreductase (phosphorylating) | Pyruvate + Orthophosphate + Oxygen <=> Acetyl phosphate + H2O2 + CO2 | Pyruvate metabolism | 1.2.3.3
0.046 | 0.02 | 0.072 | R00431 | GTP:oxaloacetate carboxy-lyase (transphosphorylating) | GTP + Oxaloacetate <=> GDP + Phosphoenolpyruvate + CO2 | Citrate cycle (TCA cycle),Pyruvate metabolism | 4.1.1.32
0.0455 | 0.045 | 0.046 | R00665 | L-Citrulline N5-carbamoyldihydrolase | L-Citrulline + H2O <=> L-Ornithine + CO2 + NH3 |  | 3.5.1.20
0.0455 | 0.043 | 0.048 | R00725 | ITP:D-hexose 6-phosphotransferase | ITP + D-Glucose <=> IDP + D-Glucose 6-phosphate |  | 2.7.1.1
0.0455 | 0.005 | 0.086 | R00516 | UTP:cytidine 5\'-phosphotransferase | UTP + Cytidine <=> UDP + CMP | Pyrimidine metabolism | 2.7.1.48
0.0435 | 0.081 | 0.006 | R01289 | L-Serine hydro-lyase (adding homocysteine) | L-Serine + L-Homocysteine <=> Cystathionine + H2O |  | 4.2.1.22
0.0435 | 0.017 | 0.07 | R01879 | 2-Deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2\'-hydroxylating) | [NAME] <=> Uridine + Succinate + CO2 |  | 1.14.11.3
0.0435 | 0.005 | 0.082 | R00962 | ITP:cytidine 5\'-phosphotransferase | ITP + Cytidine <=> IDP + CMP | Pyrimidine metabolism | 2.7.1.48
0.043 | 0.081 | 0.005 | EC284 | succinyl-CoA synthetase (ADP-forming) | [c]atp + coa + succ <==> adp + pi + succoa | Citrate Cycle (TCA) | EC-6.2.1.5
0.0425 | 0.063 | 0.022 | R01580 | Pyridoxamine-5\'-phosphate:2-oxoglutarate aminotransferase | Pyridoxamine phosphate + 2-Oxoglutarate <=> Pyridoxal phosphate + D-Glutamate | [NAME] metabolism | 2.6.1.54
0.0425 | 0.032 | 0.053 | R05607 | D-sorbitol-6-phosphate:NAD 2-oxidoreductase | Sorbitol 6-phosphate + NAD+ <=> beta-D-Fructose 6-phosphate + NADH + H+ | Fructose and mannose metabolism | 1.1.1.140
0.042 | 0.082 | 0.002 | R01900 | Isocitrate hydro-lyase | Isocitrate <=> cis-Aconitate + H2O | Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,Reductive carboxylate cycle (CO2 fixation) | 4.2.1.3
0.042 | 0.082 | 0.002 | R01325 | Citrate hydro-lyase | Citrate <=> cis-Aconitate + H2O | Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,Reductive carboxylate cycle (CO2 fixation) | 4.2.1.3         4.2.1.4
0.042 | 0.049 | 0.035 | EC656 | glucose 6-phosphate dehydrogenase | [c]g6p + nadp <==> 6pgl + h + nadph | Pentose Phosphate Cycle | EC-1.1.1.49
0.0415 | 0.001 | 0.082 | R00357 | L-Aspartic acid:oxygen oxidoreductase (deaminating) | L-Aspartate + H2O + Oxygen <=> Oxaloacetate + NH3 + H2O2 | Alanine and aspartate metabolism | 1.4.3.2         1.4.3.16
0.0415 | 0 | 0.083 | R00513 | ATP:cytidine 5\'-phosphotransferase | ATP + Cytidine <=> ADP + CMP | Pyrimidine metabolism | 2.7.1.48
0.0405 | 0.028 | 0.053 | R00928 | Acetyl-CoA:propanoate CoA-transferase | Acetyl-CoA + Propanoate <=> Acetate + Propanoyl-CoA | Pyruvate metabolism,Propanoate metabolism | 2.8.3.1
0.0405 | 0.019 | 0.062 | EC543 | deoxyuridine phosphorylase | [c]duri + pi <==> 2dr1p + ura | Nucleotide Salvage Pathways
0.04 | 0.009 | 0.071 | R01052 | ADP:D-ribose-5-phosphate adenylyltransferase | ADP + D-Ribose 5-phosphate <=> Orthophosphate + ADP-ribose |  | 2.7.7.35
0.0395 | 0.047 | 0.032 | R05862 | sarcosine:oxygen oxidoreductase (deaminating) | Sarcosine + H2O + Oxygen <=> Glyoxylate + Methylamine + H2O2 |  | 1.4.3.19
0.0395 | 0.027 | 0.052 | R00303 | D-Glucose-6-phosphate phosphohydrolase | D-Glucose 6-phosphate + H2O <=> D-Glucose + Orthophosphate |  | 3.1.3.9         3.1.3.58
0.0395 | 0.023 | 0.056 | R02407 | Succinyl-CoA:citramalate CoA-transferase | Succinyl-CoA + Itaconate <=> Succinate + Itaconyl-CoA | C5-Branched dibasic acid metabolism | 2.8.3.7
0.0395 | 0.021 | 0.058 | R02738 | Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase | Protein N(pi)-phospho-L-histidine + D-Glucose <=> Protein histidine + alpha-D-Glucose 6-phosphate | Glycolysis / Gluconeogenesis | 2.7.1.69
0.0395 | 0.017 | 0.062 | R07395 | 5-(Methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing) | 2,3-Diketo-5-methylthiopentyl-1-phosphate + H2O <=> 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one + Orthophosphate |  | 3.1.3.77
0.0395 | 0 | 0.079 | EC389 | nicotinamidase | [c]h2o + ncam --> nac + nh4 | Cofactor and Prosthetic Group Biosynthesis | EC-3.5.1.19
0.039 | 0.078 | 0 | EC516 | methylglyoxal synthase | [c]dhap --> mthgxl + pi | [NAME] | EC-4.2.3.3
0.0385 | 0.024 | 0.053 | R00875 | D-Glucitol:NAD+ 2-oxidoreductase | D-Sorbitol + NAD+ <=> D-Fructose + NADH + H+ | Fructose and mannose metabolism | 1.1.1.14        1.1.1.15
0.0385 | 0.023 | 0.054 | R01787 | alpha-D-Glucose:NADP+ 1-oxidoreductase | D-Sorbitol + NADP+ <=> alpha-D-Glucose + NADPH + H+ | Fructose and mannose metabolism | 1.1.1.21
0.0385 | 0.019 | 0.058 | EC579 | deoxyuridine kinase (ATP:[NAME]) | [c]atp + duri --> adp + dump + h | Nucleotide Salvage Pathways
0.038 | 0.076 | 0 | R04673 | (S)-2-Aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating) | 2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate | [NAME], leucine and isoleucine biosynthesis | 2.2.1.6
0.038 | 0.076 | 0 | R01794 | NADPH:6,7-dihydropteridine oxidoreductase | Dihydrobiopterin + NADPH + H+ <=> Tetrahydrobiopterin + NADP+ | Folate biosynthesis | 1.5.1.34
0.038 | 0.076 | 0 | R01515 | 3-Phospho-D-glyceroyl phosphate phosphohydrolase | 3-Phospho-D-glyceroyl phosphate + H2O <=> 3-Phospho-D-glycerate + Orthophosphate | Glycolysis / Gluconeogenesis | 3.6.1.7
0.038 | 0.07 | 0.006 | R01285 | [NAME]-lyase (deaminating) | Cystathionine + H2O <=> L-Homocysteine + NH3 + Pyruvate | Nitrogen metabolism,[NAME] metabolism | 4.4.1.8
0.038 | 0.034 | 0.042 | R00866 | ATP:D-fructose 1-phosphotransferase | ATP + D-Fructose <=> ADP + D-Fructose 1-phosphate | Fructose and mannose metabolism | 2.7.1.3
0.038 | 0.034 | 0.042 | R00722 | ATP:nucleoside-diphosphate phosphatransferase | ATP + IDP <=> ADP + ITP | Purine metabolism | 2.7.4.6
0.038 | 0.026 | 0.05 | R02154 | L-Glutamate:histamine ligase | ATP + L-Glutamate + 1H-Imidazole-4-ethanamine <=> AMP + N(alpha)-gamma-L-Glutamylhistamine + Pyrophosphate |  | 6.3.2.18
0.038 | 0.026 | 0.05 | R02153 | L-Glutamate:histamine ligase | ATP + L-Glutamate + 1H-Imidazole-4-ethanamine <=> ADP + N(alpha)-gamma-L-Glutamylhistamine + Orthophosphate |  | 6.3.2.18
0.0375 | 0.027 | 0.048 | R07296 | choloyl-CoA hydrolase | Choloyl-CoA + H2O <=> 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + CoA |  | 3.1.2.27
0.0375 | 0.027 | 0.048 | R02794 | Cholate:CoA ligase (AMP-forming) | ATP + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + CoA <=> AMP + Pyrophosphate + Choloyl-CoA | Bile acid biosynthesis | 6.2.1.7
0.037 | 0.073 | 0.001 | R00354 | (3S)-Citryl-CoA oxaloacetate-lyase | (3S)-Citryl-CoA <=> Acetyl-CoA + Oxaloacetate | Citrate cycle (TCA cycle) | 4.1.3.34
0.037 | 0.057 | 0.017 | EC180 | glutamate 5-kinase | [c]atp + glu-L --> adp + glu5p | Arginine and Proline Metabolism | EC-2.7.2.11
0.037 | 0.057 | 0.017 | EC179 | glutamate-5-semialdehyde dehydrogenase | [c]glu5p + h + nadph --> glu5sa + nadp + pi | Arginine and Proline Metabolism | EC-1.2.1.41
0.037 | 0.049 | 0.025 | R00614 | Formaldehyde:formaldehyde oxidoreductase | 2 Formaldehyde + H2O <=> Formate + Methanol |  | 1.2.99.4
0.037 | 0.031 | 0.043 | R07315 | carbamate hydro-lyase | Cyanate + H2O <=> Carbamate |  | 4.2.1.104
0.037 | 0.031 | 0.043 | R03546 | Cyanate C-N-lyase | Cyanate + H+ + HCO3- <=> CO2 + Carbamate | Nitrogen metabolism | 4.2.1.104
0.0365 | 0.063 | 0.01 | R01344 | D-Amino acid:pyruvate aminotransferase | D-Amino acid + Pyruvate <=> 2-Oxo acid + D-Alanine | D-Alanine metabolism | 2.6.1.41
0.0365 | 0.022 | 0.051 | R01965 | dATP:D-hexose 6-phosphotransferase | dATP + D-Glucosamine <=> dADP + D-Glucosamine 6-phosphate |  | 2.7.1.1
0.0365 | 0.02 | 0.053 | R01620 | Acetyl-phosphate:L-lysine N6-acetyltransferase | Acetyl phosphate + L-Lysine <=> Orthophosphate + N6-Acetyl-L-lysine | Lysine degradation | 2.3.1.32
0.0365 | 0.01 | 0.063 | R02404 | Itaconate:CoA ligase (ADP-forming) | ATP + Itaconate + CoA <=> ADP + Orthophosphate + Itaconyl-CoA | C5-Branched dibasic acid metabolism | 6.2.1.5
0.036 | 0.052 | 0.02 | [NAME] | L-Alanine:2-oxo-acid aminotransferase | L-Alanine + 2-Oxo acid <=> Pyruvate + L-Amino acid |  | 2.6.1.12
0.036 | 0.028 | 0.044 | R02625 | ATP:protein-L-histidine N(pi)-phosphotransferase | ATP + Protein histidine <=> ADP + Protein N(pi)-phospho-L-histidine |  | 2.7.13.1
0.0355 | 0.071 | 0 | R05069 | (S)-2-Aceto-2-hydroxybutanoate:NADP+ oxidoreductase (isomerizing) | (S)-2-Aceto-2-hydroxybutanoate <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate | [NAME], leucine and isoleucine biosynthesis | 1.1.1.86        5.4.99.3
0.0355 | 0.071 | 0 | R05068 | (R)-2,3-Dihydroxy-3-methylpentanoate:NADP+ oxidoreductase (isomerizing) | (R)-2,3-Dihydroxy-3-methylpentanoate + NADP+ <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate + NADPH + H+ | [NAME], leucine and isoleucine biosynthesis | 1.1.1.86
0.0355 | 0.071 | 0 | R04672 | (S)-2-Acetolactate pyruvate-lyase (carboxylating) | (S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate | [NAME], leucine and isoleucine biosynthesis | 2.2.1.6
0.0355 | 0.069 | 0.002 | EC588 | 5'-nucleotidase (dTMP) | [c]dtmp + h2o --> pi + thymd | Nucleotide Salvage Pathways | EC-3.1.3.5
0.0355 | 0.021 | 0.05 | R02406 | Itaconate:CoA ligase (IDP-forming) | ITP + Itaconate + CoA <=> IDP + Orthophosphate + Itaconyl-CoA |  | 6.2.1.4
0.0345 | 0.026 | 0.043 | R02867 | ITP:D-hexose 6-phosphotransferase | ITP + D-Sorbitol <=> IDP + Sorbitol 6-phosphate |  | 2.7.1.1
0.0345 | 0 | 0.069 | R01768 | [NAME]:NAD+ oxidoreductase | Hypoxanthine + NAD+ + H2O <=> [NAME] | Purine metabolism | 1.17.1.4
0.034 | 0.041 | 0.027 | R00412 | Succinate:(acceptor) oxidoreductase | Succinate + Acceptor <=> Fumarate + Reduced acceptor | Citrate cycle (TCA cycle),Benzoate degradation via CoA ligation | 1.3.99.1
0.0335 | 0.023 | 0.044 | R02145 | [NAME] aminohydrolase | [NAME] <=> Xanthosine + NH3 |  | 3.5.4.15
0.0335 | 0.02 | 0.047 | R00867 | ATP:D-fructose 6-phosphotransferase | ATP + D-Fructose <=> ADP + beta-D-Fructose 6-phosphate | Fructose and mannose metabolism | 2.7.1.1         2.7.1.4
0.0335 | 0.012 | 0.055 | R02295 | Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase | Nicotinate D-ribonucleoside + Orthophosphate <=> Nicotinate + alpha-D-Ribose 1-phosphate | Nicotinate and nicotinamide metabolism | 2.4.2.1
0.0335 | 0.011 | 0.056 | R07396 |  | 4-Methylthio-2-oxobutanoic acid + L-Glutamate <=> L-Methionine + 2-Oxoglutarate | Methionine metabolism | 2.6.1.5         2.6.1.57
0.033 | 0.066 | 0 | EC677 | dihydroorotic acid (menaquinone-8) | [c]dhor-S + mqn8 --> mql8 + orot | Purine and Pyrimidine Biosynthesis | EC-1.3.3.1
0.033 | 0.021 | 0.045 | R07298 | glycerol-1-phosphate phosphohydrolase | Glycerol 1-phosphate + H2O <=> Glycerol + Orthophosphate |  | 3.1.3.21
0.0325 | 0.065 | 0 | R03012 | L-Histidinol:NAD+ oxidoreductase | L-Histidinol + NAD+ <=> L-Histidinal + NADH + H+ | Histidine metabolism | 1.1.1.23
0.0325 | 0.065 | 0 | R01793 | NADH:6,7-dihydropteridine oxidoreductase | Dihydrobiopterin + NADH + H+ <=> Tetrahydrobiopterin + NAD+ | Folate biosynthesis | 1.5.1.34
0.0325 | 0.065 | 0 | R01163 | L-Histidinal:NAD+ oxidoreductase | L-Histidinal + H2O + 2 NAD+ <=> L-Histidine + 2 NADH + H+ | Histidine metabolism | 1.1.1.23
0.0325 | 0.065 | 0 | R00397 | L-Aspartate 4-carboxy-lyase | L-Aspartate <=> L-Alanine + CO2 | Alanine and aspartate metabolism | 4.1.1.12
0.0325 | 0.021 | 0.044 | R02296 | Cytidine:orthophosphate alpha-D-ribosyltransferase | Cytidine + Orthophosphate <=> Cytosine + alpha-D-Ribose 1-phosphate | Pyrimidine metabolism | 2.4.2.2
0.032 | 0.061 | 0.003 | EC274 | fumarate reductase | [c]fum + mql8 --> mqn8 + succ | Citrate Cycle (TCA) | [NAME]
0.032 | 0.049 | 0.015 | EC568 | nucleoside-diphosphate kinase (ATP:dADP) | [c]atp + dadp <==> adp + datp | Nucleotide Salvage Pathways | EC-2.7.4.6
0.032 | 0.029 | 0.035 | R02071 | ATP:D-fructose-1-phosphate 6-phosphotransferase | ATP + D-Fructose 1-phosphate <=> ADP + beta-D-Fructose 1,6-bisphosphate | Fructose and mannose metabolism | 2.7.1.56
0.0315 | 0.035 | 0.028 | EC536 | cytidylate kinase (dCMP) | [c]atp + dcmp <==> adp + dcdp | Nucleotide Salvage Pathways | EC-2.7.4.14
0.0315 | 0.021 | 0.042 | R01964 | ITP:D-hexose 6-phosphotransferase | ITP + D-Glucosamine <=> IDP + D-Glucosamine 6-phosphate |  | 2.7.1.1
0.0315 | 0 | 0.063 | R02096 | dTTP:cytidine 5\'-phosphotransferase | dTTP + Cytidine <=> dTDP + CMP | Pyrimidine metabolism | 2.7.1.48
0.031 | 0.062 | 0 | EC427 | Tryptophanase (L-cysteine) | [c]cys-L + h2o --> h2s + nh4 + pyr | Cysteine Metabolism | EC-4.1.99.1
0.031 | 0.028 | 0.034 | EC566 | nucleoside-diphosphate kinase (ATP:dUDP) | [c]atp + dudp <==> adp + dutp | Nucleotide Salvage Pathways | EC-2.7.4.6
0.031 | 0.018 | 0.044 | [NAME] | Sorbitol-6-phosphate phosphohydrolase | Sorbitol 6-phosphate + H2O <=> D-Sorbitol + Orthophosphate |  | 3.1.3.50
0.0305 | 0.061 | 0 | R05071 | (S)-2-Acetolactate methylmutase | (S)-2-Acetolactate <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid | [NAME], leucine and isoleucine biosynthesis | 1.1.1.86        5.4.99.3
0.0305 | 0.048 | 0.013 | EC447 | pyruvate dehydrogenase | [c]coa + nad + pyr --> accoa + co2 + nadh | Glycolysis/Gluconeogenesis
0.0305 | 0.035 | 0.026 | R01039 | Glycerol:NADP+ 2-oxidoreductase | Glycerol + NADP+ <=> Glycerone + NADPH + H+ | Glycerolipid metabolism | 1.1.1.156
0.0305 | 0.035 | 0.026 | [NAME] | Acetyl-CoA:malonate CoA-transferase | Acetyl-CoA + Malonate <=> Acetate + Malonyl-CoA | beta-Alanine metabolism,Propanoate metabolism | 2.8.3.3
0.03 | 0.058 | 0.002 | R01393 | Hydroxypyruvate carboxy-lyase | Hydroxypyruvate <=> [NAME] | Glyoxylate and dicarboxylate metabolism | 4.1.1.40
0.03 | 0.035 | 0.025 | R00369 | L-Alanine:glyoxylate aminotransferase | L-Alanine + Glyoxylate <=> Pyruvate + Glycine | Alanine and aspartate metabolism,Glycine, serine and threonine metabolism | 2.6.1.44
0.03 | 0.021 | 0.039 | R01207 | N-Acyl-D-glucosamine 2-epimerase | N-Acetyl-D-glucosamine <=> N-Acetyl-D-mannosamine | Aminosugars metabolism | 5.1.3.8
0.03 | 0.015 | 0.045 | R00569 | CTP diphosphohydrolase | CTP + H2O <=> CDP + Orthophosphate | Pyrimidine metabolism | 3.6.1.5
0.03 | 0.013 | 0.047 | EC597 | 5'-nucleotidase (UMP) | [c]h2o + ump --> pi + uri | Nucleotide Salvage Pathways | EC-3.1.3.5
0.0295 | 0.05 | 0.009 | R06973 |  | 3-Oxopropanoate <=> Acetaldehyde + CO2 | 3-Chloroacrylic acid degradation | 4.1.1.-
0.0295 | 0.026 | 0.033 | R01845 | Sedoheptulose 1,7-bisphosphate 1-phosphohydrolase | Sedoheptulose 1,7-bisphosphate + H2O <=> Sedoheptulose 7-phosphate + Orthophosphate | Carbon fixation | 3.1.3.11        3.1.3.37
0.0295 | 0.02 | 0.039 | R01330 | dATP:D-hexose 6-phosphotransferase | dATP + D-Mannose <=> dADP + D-Mannose 6-phosphate |  | 2.7.1.1
0.0295 | 0.02 | 0.039 | R00414 | UDP-N-acetyl-D-glucosamine 2-epimerase | UDP-N-acetyl-D-glucosamine + H2O <=> N-Acetyl-D-mannosamine + UDP | Aminosugars metabolism | 5.1.3.14
0.029 | 0.054 | 0.004 | EC459 | phosphofructokinase | [c]atp + f6p --> adp + fdp + h | Glycolysis/Gluconeogenesis | EC-2.7.1.11
0.029 | 0.036 | 0.022 | R01655 | 5,10-Methenyltetrahydrofolate 5-hydrolase(decyclizing) | 5,10-Methenyltetrahydrofolate + H2O <=> 10-Formyltetrahydrofolate + H+ | Glyoxylate and dicarboxylate metabolism,One carbon pool by folate | 3.5.4.9         6.3.4.3
0.0285 | 0.045 | 0.012 | R01011 | ATP:glycerone phosphotransferase | ATP + Glycerone <=> ADP + Glycerone phosphate | Glycerolipid metabolism | 2.7.1.29
0.0285 | 0.03 | 0.027 | R01257 | (S)-Malate:(acceptor) oxidoreductase | (S)-Malate + FAD <=> FADH2 + Oxaloacetate | Pyruvate metabolism | 1.1.99.16
0.0285 | 0.026 | 0.031 | R01510 | 2,3-Dihydroxybenzoate:L-serine ligase | ATP + 2,3-Dihydroxybenzoate + L-Serine <=> AMP + N-(2,3-Dihydroxybenzoyl)-L-serine + Pyrophosphate |  | 6.3.2.14
0.0285 | 0.026 | 0.031 | R01509 | 2,3-Dihydroxybenzoate:L-serine ligase | ATP + 2,3-Dihydroxybenzoate + L-Serine <=> ADP + N-(2,3-Dihydroxybenzoyl)-L-serine + Orthophosphate |  | 6.3.2.14
0.028 | 0.055 | 0.001 | EC367 | L-aspartate oxidase | [c]asp-L + mqn8 --> iasp + mql8 | Cofactor and Prosthetic Group Biosynthesis
0.028 | 0.047 | 0.009 | R00094 | NADPH:oxidized-glutathione oxidoreductase | NAD+ + 2 Glutathione <=> Oxidized glutathione + NADH + H+ | Glutamate metabolism | 1.8.1.7
0.028 | 0.023 | 0.033 | R01511 | D-Glycerate-3-phosphate phosphohydrolase | 3-Phospho-D-glycerate + H2O <=> D-Glycerate + Orthophosphate | Glycine, serine and threonine metabolism | 3.1.3.38
0.028 | 0.004 | 0.052 | R02371 | dCTP:cytidine 5\'-phosphotransferase | dCTP + Cytidine <=> dCDP + CMP | Pyrimidine metabolism | 2.7.1.48
0.028 | 0.003 | 0.053 | EC529 | AMP nucleosidase | [c]amp + h2o --> ade + r5p | Nucleotide Salvage Pathways | EC-3.2.2.4
0.0275 | 0.043 | 0.012 | R01322 | Citrate:CoA ligase (ADP-forming) | ATP + Citrate + CoA <=> ADP + Orthophosphate + (3S)-Citryl-CoA | Citrate cycle (TCA cycle) | 6.2.1.18
0.0275 | 0.035 | 0.02 | R01258 | L-amino-aicd:NAD+ oxidoreductase (deaminating) | L-Amino acid + NAD+ + H2O <=> 2-Oxo acid + NH3 + NADH + H+ |  | 1.4.1.5
0.0275 | 0.016 | 0.039 | R00269 | 2-Oxoglutaramate amidohydrolase | 2-Oxoglutaramate + H2O <=> 2-Oxoglutarate + NH3 | Glutamate metabolism | 3.5.1.3
0.0275 | 0.013 | 0.042 | R00652 | L-Methionine:glyoxylate aminotransferase | L-Methionine + Glyoxylate <=> 4-Methylthio-2-oxobutanoic acid + Glycine |  | 2.6.1.73
0.0275 | 0.013 | 0.042 | R00454 |  | L-Lysine + Acetyl-CoA <=> N6-Acetyl-L-lysine + CoA | Lysine degradation | 2.3.1.-
0.0275 | 0.001 | 0.054 | R01627 | 3-Dehydroshikimate hydro-lyase | 3-Dehydroshikimate <=> 3,4-Dihydroxybenzoate + H2O | Phenylalanine, tyrosine and tryptophan biosynthesis | 4.2.1.10
0.027 | 0.054 | 0 | R00006 | 2-Acetolactate pyruvate-lyase (carboxylating) | 2-Acetolactate + CO2 <=> 2 Pyruvate | Pantothenate and CoA biosynthesis | 2.2.1.6
0.027 | 0.049 | 0.005 | R00753 | (S)-Lactate acetaldehyde-lyase | (S)-Lactate <=> Formate + Acetaldehyde | Pyruvate metabolism | 4.1.2.36
0.027 | 0.04 | 0.014 | R01259 | L-Amino-acid:oxygen oxidoreductase (deaminating) | L-Amino acid + H2O + Oxygen <=> 2-Oxo acid + NH3 + H2O2 |  | 1.4.3.2
0.027 | 0.001 | 0.053 | R00967 | UTP:uridine 5\'-phosphotransferase | UTP + Uridine <=> UDP + UMP | Pyrimidine metabolism | 2.7.1.48
0.0265 | 0.051 | 0.002 | R01851 | Methanethiol:oxygen oxidoreductase | [NAME] H2O <=> Hydrogen sulfide + Formaldehyde + H2O2 |  | 1.8.3.4
0.0265 | 0.045 | 0.008 | R00800 |  | Nitrite + H2O <=> Nitrate + 2 H+ | Nitrogen metabolism
0.0265 | 0.029 | 0.024 | R00576 | L-Glutamine:pyruvate aminotransferase | L-Glutamine + Pyruvate <=> 2-Oxoglutaramate + L-Alanine | Glutamate metabolism | 2.6.1.15
0.0265 | 0.025 | 0.028 | R00402 | succinate:NAD+ oxidoreductase | Succinate + NAD+ <=> Fumarate + NADH + H+ |  | 1.3.1.6
0.0265 | 0.001 | 0.052 | R01548 | dATP:cytidine 5\'-phosphotransferase | dATP + Cytidine <=> dADP + CMP | Pyrimidine metabolism | 2.7.1.48
0.026 | 0.052 | 0 | R00997 | 1-Aminocyclopropane-1-carboxylate endolyase (deaminating) | 1-Aminocyclopropane-1-carboxylate + H2O <=> 2-Oxobutanoate + NH3 | Propanoate metabolism | 3.5.99.7
0.026 | 0.052 | 0 | R00179 | S-Adenosyl-L-methionine methylthioadenosine-lyase | S-Adenosyl-L-methionine <=> 1-Aminocyclopropane-1-carboxylate + 5\'-Methylthioadenosine | Propanoate metabolism | 4.4.1.14
0.026 | 0.02 | 0.032 | [NAME] |  | D-arabino-3-Hexulose 6-phosphate <=> D-Fructose 6-phosphate | Pentose and glucuronate interconversions,Methane metabolism | 5.-.-.-
0.026 | 0.02 | 0.032 | [NAME] | D-arabino-3-Hexulose 6-phosphate formaldehyde-lyase | D-Ribulose 5-phosphate + Formaldehyde <=> D-arabino-3-Hexulose 6-phosphate | Pentose and glucuronate interconversions,Methane metabolism | 4.1.2.-
0.026 | 0.018 | 0.034 | R04780 | beta-D-Fructose 1,6-bisphosphate 1-phosphohydrolase | beta-D-Fructose 1,6-bisphosphate + H2O <=> beta-D-Fructose 6-phosphate + Orthophosphate | Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism | 3.1.3.11
0.0255 | 0.04 | 0.011 | R01751 | (R,R)-Tartrate carboxy-lyase | (R,R)-Tartaric acid <=> D-Glycerate + CO2 |  | 4.1.1.73
0.0255 | 0.01 | 0.041 | R01602 | alpha-D-Glucose 1-epimerase | alpha-D-Glucose <=> beta-D-Glucose | Glycolysis / Gluconeogenesis | 5.1.3.3
0.0255 | 0.004 | 0.047 | EC599 | purine-nucleoside phosphorylase (Inosine) | [c]ins + pi <==> hxan + r1p | Nucleotide Salvage Pathways | EC-2.4.2.1
0.025 | 0.045 | 0.005 | R00121 |  | Oxygen + H2O + 2 Sulfur <=> Hydrogen sulfide + Sulfite | Sulfur metabolism | 1.13.99.-
0.025 | 0.037 | 0.013 | R00703 | (S)-Lactate:NAD+ oxidoreductase | (S)-Lactate + NAD+ <=> Pyruvate + NADH + H+ | Glycolysis / Gluconeogenesis,Pyruvate metabolism | 1.1.1.27
0.025 | 0.028 | 0.022 | R01375 | L-Glutamine:phenylpyruvate aminotransferase | L-Glutamine + Phenylpyruvate <=> 2-Oxoglutaramate + L-Phenylalanine |  | 2.6.1.64
0.025 | 0.023 | 0.027 | EC587 | 5'-nucleotidase (dUMP) | [c]dump + h2o --> duri + pi | Nucleotide Salvage Pathways | EC-3.1.3.5
0.025 | 0.022 | 0.028 | R02330 | dUTP nucleotidohydrolase | dUTP + H2O <=> dUDP + Orthophosphate | Pyrimidine metabolism | 3.6.1.39
0.0245 | 0.033 | 0.016 | R00120 | Glutathione:oxygen oxidoreductase | [NAME] <=> Oxidized glutathione + H2O2 | Glutathione metabolism | 1.8.3.3         1.8.4.1         1.8.4.4
0.0245 | 0.029 | 0.02 | R00343 | (S)-Malate:NADP+ oxidoreductase | (S)-Malate + NADP+ <=> Oxaloacetate + NADPH + H+ | Pyruvate metabolism,Carbon fixation | 1.1.1.82
0.0245 | 0.02 | 0.029 | R01416 | Agmatine iminohydrolase | [NAME] <=> N-Carbamoylputrescine + NH3 | Arginine and proline metabolism | 3.5.3.12
0.024 | 0.02 | 0.028 | R04779 | ATP:D-fructose-6-phosphate 1-phosphotransferase | ATP + beta-D-Fructose 6-phosphate <=> ADP + beta-D-Fructose 1,6-bisphosphate | Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism | 2.7.1.11
0.024 | 0.018 | 0.03 | R03154 | Succinyl-CoA:citramalate CoA-transferase | Succinyl-CoA + (S)-2-Methylmalate <=> Succinate + (3S)-Citramalyl-CoA | C5-Branched dibasic acid metabolism | 2.8.3.7
0.024 | 0.014 | 0.034 | R05820 | Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase | Protein N(pi)-phospho-L-histidine + D-Sorbitol <=> Protein histidine + Sorbitol 6-phosphate | Fructose and mannose metabolism | 2.7.1.69
0.024 | 0.013 | 0.035 | EC601 | purine-nucleoside phosphorylase (Deoxyguanosine) | [c]dgsn + pi <==> 2dr1p + gua | Nucleotide Salvage Pathways | EC-2.4.2.1
0.024 | 0.003 | 0.045 | R00970 | ITP:uridine 5\'-phosphotransferase | ITP + Uridine <=> IDP + UMP | Pyrimidine metabolism | 2.7.1.48
0.0235 | 0.047 | 0 | EC420 | 3',5'-bisphosphate nucleotidase | [c]h2o + pap --> amp + pi | Cysteine Metabolism | EC-3.1.3.7
0.0235 | 0.041 | 0.006 | EC276 | fumarase | [c]fum + h2o <==> mal-L | Citrate Cycle (TCA) | EC-4.2.1.2
0.0235 | 0.02 | 0.027 | R05679 | sn-Glycerol-1-phosphate:NAD 2-oxidoreductase | Glycerol 1-phosphate + NAD+ <=> Glycerone phosphate + NADH + H+ |  | 1.1.1.261
0.0235 | 0.01 | 0.037 | R02865 | ATP:D-hexose 6-phosphotransferase | ATP + D-Sorbitol <=> ADP + Sorbitol 6-phosphate |  | 2.7.1.1
0.0235 | 0.007 | 0.04 | R01885 |  | ADP-ribose + H2O <=> alpha-D-Ribose 1-phosphate + AMP | Purine metabolism | 3.6.1.21
0.0235 | 0.006 | 0.041 | R01990 | 4-Guanidinobutanoate amidinohydrolase | 4-Guanidinobutanoate + H2O <=> 4-Aminobutanoate + Urea | Arginine and proline metabolism | 3.5.3.7
0.0235 | 0.006 | 0.041 | R01989 | L-Arginine:glycine amidinotransferase | L-Arginine + 4-Aminobutanoate <=> L-Ornithine + 4-Guanidinobutanoate | Arginine and proline metabolism | 2.1.4.1
0.023 | 0.009 | 0.037 | R01788 | alpha-D-Glucose 6-phosphate phosphohydrolase | alpha-D-Glucose 6-phosphate + H2O <=> alpha-D-Glucose + Orthophosphate | Glycolysis / Gluconeogenesis,Galactose metabolism,Starch and sucrose metabolism | 3.1.3.9
0.0225 | 0.045 | 0 | R01899 | Isocitrate:NADP+ oxidoreductase (decarboxylating) | Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+ | Citrate cycle (TCA cycle) | 1.1.1.42
0.0225 | 0.045 | 0 | R00268 | Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) | Oxalosuccinate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+ | Citrate cycle (TCA cycle) | 1.1.1.42
0.0225 | 0.045 | 0 | EC424 | phosphoadenylyl-sulfate reductase (thioredoxin) | [c]paps + trdrd --> (2) h + pap + so3 + trdox | Cysteine Metabolism | EC-1.8.4.8
0.0225 | 0.042 | 0.003 | R00585 | L-Serine:pyruvate aminotransferase | L-Serine + Pyruvate <=> Hydroxypyruvate + L-Alanine | Glycine, serine and threonine metabolism | 2.6.1.51
0.0225 | 0.038 | 0.007 | R01340 | D-Amino-acid:oxygen oxidoreductase (deaminating) | D-Amino acid + H2O + Oxygen <=> 2-Oxo acid + NH3 + H2O2 |  | 1.4.3.3
0.0225 | 0.032 | 0.013 | R01376 | L-Tryptophan:phenylpyruvate aminotransferase | L-Tryptophan + Phenylpyruvate <=> Indolepyruvate + L-Phenylalanine |  | 2.6.1.28
0.0225 | 0.025 | 0.02 | R05198 |  | Ethanol + PQQ <=> PQQH2 + Acetaldehyde | Glycolysis / Gluconeogenesis | 1.1.99.8
0.0225 | 0.025 | 0.02 | R00605 | methanol:NAD+ oxidoreductase | Methanol + NAD+ <=> Formaldehyde + NADH + H+ | Methane metabolism | 1.1.1.244
0.0225 | 0.02 | 0.025 | R01045 | Glycerol:(acceptor) 1-oxidoreductase | Glycerol + Acceptor <=> Glycerone + Reduced acceptor |  | 1.1.99.22
0.0225 | 0.015 | 0.03 | EC146 | inorganic diphosphatase | [c]h2o + ppi --> h + (2) pi | Anaplerotic reactions | EC-3.6.1.1
0.0225 | 0.005 | 0.04 | R00775 | Guanidinoacetate amidohydrolase | Guanidinoacetate + H2O <=> Glycine + Urea |  | 3.5.3.2
0.0225 | 0.005 | 0.04 | R00565 | L-Arginine:glycine amidinotransferase | L-Arginine + Glycine <=> L-Ornithine + Guanidinoacetate | Urea cycle and metabolism of amino groups,Glycine, serine and threonine metabolism,Arginine and proline metabolism | 2.1.4.1
0.022 | 0.044 | 0 | R03052 | 2-Acetolactate methylmutase | 2-Acetolactate <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid |  | 5.4.99.3
0.022 | 0.044 | 0 | R00732 | L-arogenate:NAD+ oxidoreductase | L-Arogenate + NAD+ <=> L-Tyrosine + CO2 + NADH | Phenylalanine, tyrosine and tryptophan biosynthesis | 1.3.1.43        1.3.1.79
0.022 | 0.027 | 0.017 | R00361 | (S)-Malate:(acceptor) oxidoreductase | (S)-Malate + Acceptor <=> Oxaloacetate + Reduced acceptor |  | 1.1.99.16
0.022 | 0.024 | 0.02 | R05680 | sn-Glycerol-1-phosphate:NADP 2-oxidoreductase | Glycerol 1-phosphate + NADP+ <=> Glycerone phosphate + NADPH + H+ |  | 1.1.1.261
0.022 | 0.02 | 0.024 | R02712 | 4-Methylene-L-glutamine amidohydrolase | 4-Methylene-L-glutamine + H2O <=> 4-Methylene-L-glutamate + NH3 | C5-Branched dibasic acid metabolism | 3.5.1.67
0.022 | 0.02 | 0.024 | R02711 | 4-Methylene-L-glutamate:ammonia ligase (AMP-forming) | ATP + 4-Methylene-L-glutamate + NH3 <=> AMP + Pyrophosphate + 4-Methylene-L-glutamine | C5-Branched dibasic acid metabolism | 6.3.1.7
0.0215 | 0.041 | 0.002 | R00651 | O-Acetyl-L-homoserine acetate-lyase (adding methanethiol) | O-Acetyl-L-homoserine + Methanethiol <=> L-Methionine + Acetate |  | 2.5.1.49
0.0215 | 0.037 | 0.006 | EC102 | acetate-CoA ligase (ADP-forming) | [c]atp + coa + ppa --> adp + pi + ppcoa | Alternate Carbon Metabolism | EC-6.2.1.13
0.0215 | 0.03 | 0.013 | EC333 | alanine transaminase | [c]ala-L + pydx5p --> pyam5p + pyr | Cofactor and Prosthetic Group Biosynthesis
0.0215 | 0.018 | 0.025 | R01201 | ATP:N-acetyl-D-glucosamine 6-phosphotransferase | ATP + N-Acetyl-D-glucosamine <=> ADP + N-Acetyl-D-glucosamine 6-phosphate | Glutamate metabolism,Aminosugars metabolism | 2.7.1.59
0.0215 | 0.017 | 0.026 | R01752 | D-Glyceraldehyde:NAD+ oxidoreductase | D-Glyceraldehyde + NAD+ + H2O <=> D-Glycerate + NADH + H+ | Glycerolipid metabolism | 1.2.1.3
0.0215 | 0.012 | 0.031 | EC606 | adenine deaminase | [c]ade + h + h2o --> hxan + nh4 | Nucleotide Salvage Pathways | EC-3.5.4.2
0.0215 | 0.009 | 0.034 | EC535 | deoxycytidine deaminase | [c]dcyt + h + h2o --> duri + nh4 | Nucleotide Salvage Pathways | EC-3.5.4.14
0.0215 | 0 | 0.043 | R02097 | dTTP:uridine 5\'-phosphotransferase | dTTP + Uridine <=> dTDP + UMP | Pyrimidine metabolism | 2.7.1.48
0.0215 | 0 | 0.043 | R00964 | ATP:uridine 5\'-phosphotransferase | ATP + Uridine <=> ADP + UMP | Pyrimidine metabolism | 2.7.1.48
0.021 | 0.036 | 0.006 | R00781 | Sulfur:oxygen oxidoreductase | [NAME] H2O <=> Sulfite | Sulfur metabolism | 1.13.11.18
0.021 | 0.014 | 0.028 | R03153 | Acetyl-CoA:citramalate CoA-transferase | Acetyl-CoA + (S)-2-Methylmalate <=> Acetate + (3S)-Citramalyl-CoA | C5-Branched dibasic acid metabolism | 2.8.3.11        4.1.3.22
0.021 | 0.013 | 0.029 | R01200 | N-Acetyl-D-glucosamine amidohydrolase | N-Acetyl-D-glucosamine + H2O <=> D-Glucosamine + Acetate | Aminosugars metabolism | 3.5.1.33
0.0205 | 0.039 | 0.002 | R01859 | Propanoyl-CoA:carbon-dioxide ligase (ADP-forming) | ATP + Propanoyl-CoA + HCO3- <=> ADP + Orthophosphate + (S)-2-Methyl-3-oxopropanoyl-CoA | [NAME], leucine and isoleucine degradation,Propanoate metabolism | 6.4.1.3
0.0205 | 0 | 0.041 | R02091 | dGTP:cytidine 5\'-phosphotransferase | dGTP + Cytidine <=> dGDP + CMP | Pyrimidine metabolism | 2.7.1.48
0.02 | 0.04 | 0 | R00203 | [NAME]:NAD+ oxidoreductase; [NAME]:NAD+ 2-oxidoreductase | Methylglyoxal + NAD+ + H2O <=> Pyruvate + NADH + H+ | Pyruvate metabolism | 1.2.1.22        1.2.1.23
0.02 | 0.037 | 0.003 | EC640 | succinate dehyrdogenase | [c]fadh2 + q8 <==> fad + q8h2 | Oxidative phosphorylation | EC-Undetermined
0.02 | 0.036 | 0.004 | [NAME] | 2-dehydro-3-deoxygluconokinase | [c]2ddglcn + atp --> 2ddg6p + adp + h | Alternate Carbon Metabolism | EC-2.7.1.45
0.02 | 0.034 | 0.006 | EC089 | acetaldehyde dehydrogenase (acetylating) | [c]acald + coa + nad --> accoa + h + nadh | Alternate Carbon Metabolism | [NAME]
0.02 | 0.02 | 0.02 | R01516 | 3-Phospho-D-glycerate 1,2-phosphomutase | 2,3-Bisphospho-D-glycerate + H2O <=> 3-Phospho-D-glycerate + Orthophosphate | Glycolysis / Gluconeogenesis | 3.1.3.13        5.4.2.4
0.0195 | 0.037 | 0.002 | R00930 | (S)-2-Methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase | (S)-2-Methyl-3-oxopropanoyl-CoA + Pyruvate <=> Propanoyl-CoA + Oxaloacetate | Propanoate metabolism | 2.1.3.1
0.0195 | 0.035 | 0.004 | R01538 | D-Gluconate hydro-lyase | D-Gluconic acid <=> 2-Dehydro-3-deoxy-D-gluconate + H2O | Pentose phosphate pathway | 4.2.1.39
0.0195 | 0.015 | 0.024 | R06861 | D-xylulose-5-phosphate:thiamin diphosphate glycolaldehydetransferase; alpha,beta-dihydroxyethyl-TPP:D-glyceraldehyde-3-phosphate glycolaldehydetransferase | D-Xylulose 5-phosphate + Thiamin diphosphate <=> alpha,beta-Dihydroxyethyl-TPP + (2R)-2-Hydroxy-3-(phosphonooxy)-propanal |  | 2.2.1.1         2.2.1.3
0.0195 | 0.013 | 0.026 | R01786 | ATP:D-glucose 6-phosphotransferase | ATP + alpha-D-Glucose <=> ADP + alpha-D-Glucose 6-phosphate | Glycolysis / Gluconeogenesis,Galactose metabolism,Starch and sucrose metabolism,Streptomycin biosynthesis | 2.7.1.1         2.7.1.2
0.0195 | 0.013 | 0.026 | R01339 |  | 2-Oxo acid + L-Glutamate <=> alpha-Amino acid + 2-Oxoglutarate | Nitrogen metabolism
0.0195 | 0.012 | 0.027 | R03321 | beta-D-Glucose 6-phosphate ketol-isomerase | beta-D-Glucose 6-phosphate <=> beta-D-Fructose 6-phosphate | Glycolysis / Gluconeogenesis | 5.3.1.9
0.0195 | 0.012 | 0.027 | R00763 | D-Fructose-2,6-bisphosphate 2-phosphohydrolase | beta-D-Fructose 2,6-bisphosphate + H2O <=> D-Fructose 6-phosphate + Orthophosphate |  | 3.1.3.46
0.0195 | 0.01 | 0.029 | R01789 | D-Glucose 6-sulfate sulfohydrolase | D-Glucose 6-sulfate + H2O <=> alpha-D-Glucose + Sulfate | Glycolysis / Gluconeogenesis | 3.1.6.3
0.0195 | 0.009 | 0.03 | R00874 | D-Glucose:D-fructose oxidoreductase | D-Fructose + D-Glucose <=> D-Glucono-1,5-lactone + D-Sorbitol |  | 1.1.99.28
0.0195 | 0.007 | 0.032 | EC600 | purine-nucleoside phosphorylase (Deoxyadenosine) | [c]dad-2 + pi <==> 2dr1p + ade | Nucleotide Salvage Pathways | EC-2.4.2.1
0.0195 | 0.004 | 0.035 | R02294 | N-Ribosylnicotinamide:orthophosphate ribosyltransferase | N-Ribosylnicotinamide + Orthophosphate <=> Nicotinamide + alpha-D-Ribose 1-phosphate | Nicotinate and nicotinamide metabolism | 2.4.2.1
0.0195 | 0.003 | 0.036 | R02298 | Pyrimidine-nucleoside:orthophosphate alpha-D-ribosyltransferase | Pyrimidine nucleoside + Orthophosphate <=> Pyrimidine + alpha-D-Ribose 1-phosphate |  | 2.4.2.2
0.0195 | 0.003 | 0.036 | R02172 | N-D-Ribosylpyrimidine ribohydrolase | Pyrimidine nucleoside + H2O <=> Pyrimidine + D-Ribose |  | 3.2.2.8
0.019 | 0.037 | 0.001 | EC706 | Acetaldehyde dehydrogenase | [c]accoa + (2) h + (2) nadh <==> coa + etoh + (2) nad | Pyruvate metabolism | EC-Undetermined
0.019 | 0.037 | 0.001 | EC052 | glycerol kinase | [c]atp + glyc --> adp + glyc3p + h | Alternate Carbon Metabolism | EC-2.7.1.30
0.019 | 0.003 | 0.035 | EC604 | purine-nucleoside phosphorylase (Xanthosine) | [c]pi + xtsn <==> r1p + xan | Nucleotide Salvage Pathways | EC-2.4.2.1
0.019 | 0 | 0.038 | R01549 | dATP:uridine 5\'-phosphotransferase | dATP + Uridine <=> dADP + UMP | Pyrimidine metabolism | 2.7.1.48
0.0185 | 0.037 | 0 | EC118 | L(+)-tartrate dehydratase | [c]tartr-L --> h2o + oaa | Alternate Carbon Metabolism | EC-4.2.1.32
0.0185 | 0.026 | 0.011 | R01323 | Acetyl-CoA:citrate CoA-transferase | Acetyl-CoA + Citrate <=> Acetate + (3S)-Citryl-CoA | Citrate cycle (TCA cycle) | 2.8.3.10
0.0185 | 0.021 | 0.016 | R01662 | 3-Phospho-D-glyceroyl phosphate 2,3-phosphomutase | 3-Phospho-D-glyceroyl phosphate <=> 2,3-Bisphospho-D-glycerate | Glycolysis / Gluconeogenesis | 5.4.2.1         5.4.2.4
0.0185 | 0.011 | 0.026 | R01256 | (S)-Malate:CoA ligase (ADP-forming) | ATP + (S)-Malate + CoA <=> ADP + Orthophosphate + (3S)-3-Carboxy-3-hydroxypropanoyl-CoA | Glyoxylate and dicarboxylate metabolism | 6.2.1.9
0.0185 | 0.009 | 0.028 | EC591 | 5'-nucleotidase (dCMP) | [c]dcmp + h2o --> dcyt + pi | Nucleotide Salvage Pathways | EC-3.1.3.5
0.0185 | 0.003 | 0.034 | R01271 | Nicotinamide-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase | Nicotinamide D-ribonucleotide + Pyrophosphate <=> Nicotinamide + 5-Phospho-alpha-D-ribose 1-diphosphate | Nicotinate and nicotinamide metabolism | 2.4.2.12
0.018 | 0.032 | 0.004 | EC435 | glutamate dehydrogenase (NADP) | [c]glu-L + h2o + nadp <==> akg + h + nadph + nh4 | Glutamate metabolism | EC-1.4.1.4
0.018 | 0.014 | 0.022 | R01742 | D-Gluconate:(acceptor) 2-oxidoreductase | D-Gluconic acid + Acceptor <=> 2-Dehydro-D-gluconate + Reduced acceptor |  | 1.1.99.3
0.018 | 0.012 | 0.024 | R02850 | dATP:D-hexose 6-phosphotransferase | dATP + D-Hexose <=> dADP + D-Hexose 6-phosphate |  | 2.7.1.1
0.0175 | 0.03 | 0.005 | EC097 | Phosphofructokinase | [c]atp + tag6p-D --> adp + h + tagdp-D | Alternate Carbon Metabolism | EC-2.7.1.11
0.0175 | 0.016 | 0.019 | R05652 | taurine:pyruvate aminotransferase | Taurine + Pyruvate <=> [NAME] + L-Alanine | Taurine and hypotaurine metabolism | 2.6.1.77
0.0175 | 0.016 | 0.019 | R01873 | Quinate:pyrroloquinoline-quinone 5-oxidoreductase | Quinate + PQQ <=> PQQH2 + 3-Dehydroquinate | Phenylalanine, tyrosine and tryptophan biosynthesis | 1.1.99.25
0.0175 | 0.005 | 0.03 | R03346 | Nicotinate D-ribonucleotide phosphohydrolase | Nicotinate D-ribonucleotide + H2O <=> Nicotinate D-ribonucleoside + Orthophosphate | Nicotinate and nicotinamide metabolism | 3.1.3.5
0.0175 | 0.004 | 0.031 | R01175 | Butanoyl-CoA:oxygen 2-oxidoreductase | Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA | Fatty acid metabolism | 1.3.3.6         1.3.99.2        1.3.99.3        1.3.99.-
0.017 | 0.032 | 0.002 | [NAME] | glutamate synthase (NADPH) | [c]akg + gln-L + h + nadph --> (2) [NAME] | Glutamate metabolism | EC-1.4.1.13
0.017 | 0.03 | 0.004 | EC034 | Dihydroxyacetone phosphotransferase | [c]dha + pep --> dhap + pyr | Alternate Carbon Metabolism
0.017 | 0.025 | 0.009 | EC332 | D-alanine transaminase | [c]ala-D + pydx5p --> pyam5p + pyr | Cofactor and Prosthetic Group Biosynthesis
0.017 | 0.023 | 0.011 | R00755 |  | Acetaldehyde + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate | Glycolysis / Gluconeogenesis | 4.1.1.1
0.017 | 0.011 | 0.023 | [NAME] | Acylneuraminyl hydrolase | GT1b + N-Acetylneuraminate <=> GQ1 + H2O |  | 3.2.1.18
0.017 | 0.011 | 0.023 | R05114 |  | CMP-N-acetylneuraminate + GT1b <=> CMP + GQ1 |  | 2.4.99.-
0.017 | 0.008 | 0.026 | R06863 | D-Sedoheptulose-7-phosphate:thiamin diphosphate glycolaldehydetransferase | D-Sedoheptulose 7-phosphate + Thiamin diphosphate <=> alpha,beta-Dihydroxyethyl-TPP + D-Ribose 5-phosphate |  | 2.2.1.1
0.0165 | 0.033 | 0 | R00654 | L-Methionine methanethiol-lyase (deaminating) | L-Methionine + H2O <=> Methanethiol + NH3 + 2-Oxobutanoate |  | 4.4.1.11
0.0165 | 0.032 | 0.001 | EC283 | succinate dehydrogenase | [c]fad + succ --> fadh2 + fum | Citrate Cycle (TCA) | [NAME]
0.0165 | 0.031 | 0.002 | R00588 | L-Serine:glyoxylate aminotransferase | L-Serine + Glyoxylate <=> Hydroxypyruvate + Glycine | Glycine, serine and threonine metabolism | 2.6.1.45
0.0165 | 0.025 | 0.008 | EC596 | 5'-nucleotidase (XMP) | [c]h2o + xmp --> pi + xtsn | Nucleotide Salvage Pathways | EC-3.1.3.5
0.0165 | 0.016 | 0.017 | R01819 | D-Mannose-6-phosphate ketol-isomerase | D-Mannose 6-phosphate <=> beta-D-Fructose 6-phosphate | Fructose and mannose metabolism | 5.3.1.8
0.0165 | 0.012 | 0.021 | [NAME] | D-Glucose 6-sulfate sulfohydrolase | D-Glucose 6-sulfate + H2O <=> D-Glucose + Sulfate |  | 3.1.6.3
0.0165 | 0.007 | 0.026 | R01152 | N-Carbamoylputrescine amidohydrolase | N-Carbamoylputrescine + H2O <=> Putrescine + CO2 + NH3 | Arginine and proline metabolism | 3.5.1.53
0.0165 | 0.006 | 0.027 | R04634 |  | N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D- glucosylceramide + H2O <=> GA2 + N-Acetylneuraminate |  | 3.2.1.18
0.0165 | 0.006 | 0.027 | R04630 | CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase | CMP-N-acetylneuraminate + GA2 <=> CMP + N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D- glucosylceramide |  | 2.4.99.9
0.0165 | 0.006 | 0.027 | EC589 | 5'-nucleotidase (dAMP) | [c]damp + h2o --> dad-2 + pi | Nucleotide Salvage Pathways | EC-3.1.3.5
0.0165 | 0.005 | 0.028 | R01279 | Palmitoyl-CoA:oxygen 2-oxidoreductase | Palmitoyl-CoA + FAD <=> trans-Hexadec-2-enoyl-CoA + FADH2 | Fatty acid metabolism | 1.3.3.6         1.3.99.3        1.3.99.13       1.3.99.-
0.0165 | 0 | 0.033 | R01886 | N(omega)-(ADP-D-ribosyl)-L-arginine ADPribosylhydrolase | N(omega)-(ADP-D-ribosyl)-L-arginine + H2O <=> L-Arginine + ADP-ribose |  | 3.2.2.19
0.0165 | 0 | 0.033 | R00555 | NAD+:L-arginine ADP-D-ribosyltransferase | NAD+ + L-Arginine <=> Nicotinamide + N(omega)-(ADP-D-ribosyl)-L-arginine |  | 2.4.2.31
0.0165 | 0 | 0.033 | R00396 | L-Alanine:NAD+ oxidoreductase (deaminating) | L-Alanine + NAD+ + H2O <=> Pyruvate + NH3 + NADH + H+ | Taurine and hypotaurine metabolism,Reductive carboxylate cycle (CO2 fixation) | 1.4.1.1
0.016 | 0.032 | 0 | R04467 |  | N6-Acetyl-LL-2,6-diaminoheptanedioate + 2-Oxoglutarate <=> N-Acetyl-L-2-amino-6-oxopimelate + L-Glutamate | Lysine biosynthesis | 2.6.1.-
0.016 | 0.032 | 0 | R04364 | Acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase | 2,3,4,5-Tetrahydrodipicolinate + Acetyl-CoA + H2O <=> N-Acetyl-L-2-amino-6-oxopimelate + CoA | Lysine biosynthesis | 2.3.1.89
0.016 | 0.032 | 0 | R02733 | N6-Acetyl-LL-2,6-diaminoheptanedioate amidohydrolase | N6-Acetyl-LL-2,6-diaminoheptanedioate + H2O <=> Acetate + LL-2,6-Diaminoheptanedioate | Lysine biosynthesis | 3.5.1.47
0.016 | 0.032 | 0 | EC433 | formyltetrahydrofolate deformylase | [c]10fthf + h2o --> for + h + thf | Folate Metabolism | EC-3.5.1.10
0.016 | 0.025 | 0.007 | R07166 | D-amino-acid:(acceptor) oxidoreductase (deaminating) | D-Amino acid + H2O + Acceptor <=> 2-Oxo acid + NH3 + Reduced acceptor |  | 1.4.99.1
0.016 | 0.021 | 0.011 | R01748 | D-Glycerate-2-phosphate phosphohydrolase | 2-Phospho-D-glycerate + H2O <=> D-Glycerate + Orthophosphate |  | 3.1.3.20
0.016 | 0.011 | 0.021 | R01741 | D-Gluconate:(acceptor) 2-oxidoreductase | D-Gluconic acid + FAD <=> 2-Dehydro-D-gluconate + FADH2 | Pentose phosphate pathway | 1.1.99.3
0.016 | 0.01 | 0.022 | R01327 | ITP:D-hexose 6-phosphotransferase | ITP + D-Mannose <=> IDP + D-Mannose 6-phosphate |  | 2.7.1.1
0.016 | 0.009 | 0.023 | R01204 | Acetyl-CoA:D-glucosamine N-acetyltransferase | Acetyl-CoA + D-Glucosamine <=> CoA + N-Acetyl-D-glucosamine | Aminosugars metabolism | 2.3.1.3
0.016 | 0.006 | 0.026 | R02372 | dUTP:cytidine 5\'-phosphotransferase | dUTP + Cytidine <=> dUDP + CMP | Pyrimidine metabolism | 2.7.1.48
0.016 | 0.006 | 0.026 | R01684 | Taurine:2-oxoglutarate aminotransferase | Taurine + 2-Oxoglutarate <=> [NAME] + L-Glutamate |  | 2.6.1.55
0.016 | 0.002 | 0.03 | [NAME] | Uridine ribohydrolase | Uridine + H2O <=> Uracil + D-Ribose | Pyrimidine metabolism | 3.2.2.3
0.0155 | 0.031 | 0 | EC334 | glutathione oxidoreductase | [c]gthox + h + nadph <==> (2) [NAME] | Cofactor and Prosthetic Group Biosynthesis | EC-1.6.4.2
0.0155 | 0.028 | 0.003 | R00466 | Glyoxylate:oxygen oxidoreductase | Glyoxylate + Oxygen + H2O <=> Oxalate + H2O2 | Glyoxylate and dicarboxylate metabolism | 1.2.3.5
0.0155 | 0.002 | 0.029 | R04648 | CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase | CMP-N-acetylneuraminate + D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D- galactosyl-D-glucosylceramide <=> CMP + N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosylceramide |  | 2.4.99.2        2.4.99.4
0.015 | 0.024 | 0.006 | R01265 | L-Amino acid racemase | L-Amino acid <=> D-Amino acid |  | 5.1.1.10
0.015 | 0.021 | 0.009 | [NAME] | D-Amino acid dehydrogenase | [c]ala-D + fad + h2o --> fadh2 + nh4 + pyr | Alanine and aspartate metabolism | EC-1.4.99.1
0.015 | 0.013 | 0.017 | R07167 | taurine:(acceptor) oxidoreductase (deaminating) | Taurine + H2O + Acceptor <=> Sulfoacetaldehyde + NH3 + Reduced acceptor |  | 1.4.99.2
0.015 | 0.007 | 0.023 | R03347 |  | Nicotinate D-ribonucleotide + ADP <=> Nicotinate D-ribonucleoside + ATP | Nicotinate and nicotinamide metabolism | 2.7.1.-
0.015 | 0.006 | 0.024 | R02111 | 1,4-alpha-D-Glucan:orthophosphate alpha-D-glucosyltransferase | [NAME] <=> Amylose + D-Glucose 1-phosphate | Starch and sucrose metabolism | 2.4.1.1
0.015 | 0.006 | 0.024 | R02109 | Dextrin 6-alpha-D-glucanohydrolase | Starch + H2O <=> Amylose + alpha-D-Glucose | Starch and sucrose metabolism | 3.2.1.33
0.015 | 0.002 | 0.028 | EC550 | [NAME] (Hypoxanthine) | [c]hxan + prpp --> imp + ppi | Nucleotide Salvage Pathways | EC-2.4.2.8
0.0145 | 0.029 | 0 | R01769 | Hypoxanthine:oxygen oxidoreductase | [NAME] <=> Xanthine + H2O2 | Purine metabolism | 1.17.3.2
0.0145 | 0.029 | 0 | R00533 | Sulfite:oxygen oxidoreductase | Sulfite + Oxygen + H2O <=> Sulfate + H2O2 | Sulfur metabolism | 1.8.3.1
0.0145 | 0.029 | 0 | EC446 | L-threonine dehydrogenase | [[NAME] --> 2aobut + h + nadh | Glycine and Serine Metabolism | EC-1.1.1.103
0.0145 | 0.029 | 0 | EC441 | glycine C-acetyltransferase (irreversible) | [c]2aobut + coa --> accoa + gly | Glycine and Serine Metabolism | EC-2.3.1.29
0.0145 | 0.028 | 0.001 | R07316 | carbamate hydro-lyase | Carbamate <=> NH3 + CO2 |  | 4.2.1.104
0.0145 | 0.028 | 0.001 | [NAME] | ATP:carbamate phosphotransferase | [NAME] <=> ADP + Carbamoyl phosphate | Nitrogen metabolism | 2.7.2.2
0.0145 | 0.017 | 0.012 | R00282 | NADPH:(quinone-acceptor) oxidoreductase | Acceptor + NADPH + H+ <=> Reduced acceptor + NADP+ |  | 1.6.99.1        1.6.99.6
0.0145 | 0.011 | 0.018 | R02658 | ATP:2-dehydro-D-gluconate 6-phosphate | ATP + 2-Dehydro-D-gluconate <=> ADP + 6-Phospho-2-dehydro-D-gluconate | Pentose phosphate pathway | 2.7.1.13
0.0145 | 0.006 | 0.023 | R03491 |  | beta-D-Galactosyl-1,4-beta-D-glucosylceramide + N-Acetylneuraminate <=> GM3 + H2O |  | 3.2.1.18
0.0145 | 0.003 | 0.026 | EC595 | 5'-nucleotidase (IMP) | [c]h2o + imp --> ins + pi | Nucleotide Salvage Pathways | EC-3.1.3.5
0.0145 | 0.002 | 0.027 | [NAME] |  | D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D- galactosyl-D-glucosylceramide + N-Acetylneuraminate <=> N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosylceramide + H2O |  | 3.2.1.18
0.0145 | 0 | 0.029 | R00181 | AMP aminohydrolase | AMP + H2O <=> IMP + NH3 | Purine metabolism | 3.5.4.6         3.5.4.17
0.014 | 0.016 | 0.012 | R01607 | 3-Oxopropanoate:NADP+ oxidoreductase | 3-Oxopropanoate + NADP+ + H2O <=> Malonate + NADPH + H+ | beta-Alanine metabolism | 1.2.1.15
0.014 | 0.014 | 0.014 | [NAME] | Sarcosine:oxygen oxidoreductase (demethylating) | Sarcosine + H2O + Oxygen <=> Glycine + Formaldehyde + H2O2 | Glycine, serine and threonine metabolism | 1.5.3.1
0.014 | 0.013 | 0.015 | R00366 | Aminoacetic acid:oxygen oxidoreductase (deaminating) | Glycine + H2O + Oxygen <=> Glyoxylate + NH3 + H2O2 | Glycine, serine and threonine metabolism | 1.4.3.3         1.4.3.19
0.014 | 0.008 | 0.02 | R00957 | alpha-D-Glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating) | 2 D-Glucose 1-phosphate + H2O <=> [NAME] |  | 2.4.1.139
0.014 | 0.007 | 0.021 | R01178 | Butanoyl-CoA:(acceptor) 2,3-oxidoreductase | Butanoyl-CoA + Acceptor <=> Crotonoyl-CoA + Reduced acceptor |  | 1.3.99.2
0.014 | 0.006 | 0.022 | [NAME] |  | GT1b + H2O <=> GD1b + N-Acetylneuraminate |  | 3.2.1.18
0.014 | 0.003 | 0.025 | [NAME] | ATP:N-ribosylnicotinamide 5\'-phosphotransferase | ATP + N-Ribosylnicotinamide <=> ADP + Nicotinamide D-ribonucleotide | Nicotinate and nicotinamide metabolism | 2.7.1.22
0.0135 | 0.027 | 0 | EC114 | 2-Oxobutanoate formate lyase | [c]2obut + coa --> for + ppcoa | Alternate Carbon Metabolism
0.0135 | 0.026 | 0.001 | EC134 | Propanoyl-CoA: succinate CoA-transferase | [c]ppcoa + succ --> ppa + succoa | Alternate Carbon Metabolism
0.0135 | 0.018 | 0.009 | R00476 | Glycolate:(acceptor) 2-oxidoreductase | Glycolate + Acceptor <=> Glyoxylate + Reduced acceptor | Glyoxylate and dicarboxylate metabolism | 1.1.99.14
0.0135 | 0.015 | 0.012 | EC196 | Phosphatidate phosphatase | [c]h2o + (0.02) pa_EC --> (0.02) 12dgr_EC + pi | Cell Envelope Biosynthesis | EC-3.1.3.4
0.0135 | 0.012 | 0.015 | [NAME] | 2-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase | 2-Methylbutanoyl-CoA + FAD <=> 2-Methylbut-2-enoyl-CoA + FADH2 | [NAME], leucine and isoleucine degradation | 1.3.99.3        1.3.99.12
0.0135 | 0.012 | 0.015 | R02293 | L-2,4-Diaminobutanoate:pyruvate aminotransferase | L-2,4-Diaminobutanoate + Pyruvate <=> L-Aspartate 4-semialdehyde + L-Alanine |  | 2.6.1.46
0.0135 | 0.01 | 0.017 | R02050 | (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase | (R)-3-Amino-2-methylpropanoate + Pyruvate <=> 2-Methyl-3-oxopropanoate + L-Alanine |  | 2.6.1.40
0.0135 | 0.01 | 0.017 | R02048 | (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase | (R)-3-Amino-2-methylpropanoate + 2-Oxoglutarate <=> 2-Methyl-3-oxopropanoate + L-Glutamate |  | 2.6.1.40
0.0135 | 0.008 | 0.019 | R00724 | ITP:pyruvate O2-phosphotransferase | ITP + Pyruvate <=> IDP + Phosphoenolpyruvate |  | 2.7.1.40
0.0135 | 0.007 | 0.02 | R00155 | UDP diphosphohydrolase | UDP + H2O <=> UMP + Orthophosphate | Pyrimidine metabolism | 3.6.1.5         3.6.1.6
0.0135 | 0.006 | 0.021 | R00689 | L-Phenylalanine:oxygen oxidoreductase (deaminating) | L-Phenylalanine + H2O + Oxygen <=> Phenylpyruvate + NH3 + H2O2 | Phenylalanine metabolism,[NAME], tyrosine and tryptophan biosynthesis | 1.4.3.2
0.0135 | 0.005 | 0.022 | R03488 | CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase | CMP-N-acetylneuraminate + beta-D-Galactosyl-1,4-beta-D-glucosylceramide <=> CMP + GM3 |  | 2.4.99.9
0.0135 | 0.001 | 0.026 | R02139 | Barbiturate amidohydrolase | Barbiturate + 2 H2O <=> Malonate + Urea | Pyrimidine metabolism | 3.5.2.1
0.0135 | 0.001 | 0.026 | R00976 | uracil:acceptor oxidoreductase | Uracil + Acceptor + H2O <=> Barbiturate + Reduced acceptor | Pyrimidine metabolism | 1.17.99.4
0.013 | 0.026 | 0 | R00205 | 2-Oxopropanal:NADP+ oxidoreductase | Methylglyoxal + NADP+ + H2O <=> Pyruvate + NADPH | Pyruvate metabolism | 1.2.1.49
0.013 | 0.025 | 0.001 | EC457 | hexokinase (D-glucose:ATP) | [c]atp + glc-D --> adp + g6p + h | Glycolysis/Gluconeogenesis | EC-2.7.1.1
0.013 | 0.022 | 0.004 | R01220 | 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase | 5,10-Methylenetetrahydrofolate + NADP+ <=> 5,10-Methenyltetrahydrofolate + NADPH + H+ | Glyoxylate and dicarboxylate metabolism,One carbon pool by folate | 1.5.1.5
0.013 | 0.021 | 0.005 | R00864 |  | Sulfite + Sulfur <=> Thiosulfate | Sulfur metabolism
0.013 | 0.016 | 0.01 | R00410 | [NAME] CoA-transferase | Succinyl-CoA + Acetoacetate <=> Succinate + Acetoacetyl-CoA | Synthesis and degradation of ketone bodies,[NAME], leucine and isoleucine degradation,Butanoate metabolism | 2.8.3.5
0.013 | 0.014 | 0.012 | R01559 | Succinyl-CoA:oxalate CoA-transferase | Succinyl-CoA + Oxalate <=> Succinate + Oxalyl-CoA | Glyoxylate and dicarboxylate metabolism | 2.8.3.2
0.013 | 0.014 | 0.012 | R00611 | Sarcosine:(acceptor) oxidoreductase (demethylating) | Sarcosine + Acceptor + H2O <=> Glycine + Formaldehyde + Reduced acceptor | Urea cycle and metabolism of amino groups,Glycine, serine and threonine metabolism | 1.5.99.1
0.013 | 0.013 | 0.013 | R01146 |  | Methanol + PQQ <=> PQQH2 + Formaldehyde | Methane metabolism | 1.1.99.8
0.013 | 0.01 | 0.016 | R01326 | ATP:D-glucose 6-phosphotransferase | ATP + D-Mannose <=> ADP + D-Mannose 6-phosphate | Fructose and mannose metabolism | 2.7.1.1         2.7.1.7
0.013 | 0.009 | 0.017 | R00300 | D-Glucose:NAD+ 1-oxidoreductase | D-Glucose + NAD+ <=> D-Glucono-1,5-lactone + NADH + H+ |  | 1.1.1.118
0.013 | 0.007 | 0.019 | R00919 |  | Propanoyl-CoA + NADP+ <=> Propenoyl-CoA + NADPH | Propanoate metabolism | 1.3.1.-
0.013 | 0.006 | 0.02 | R05116 |  | CMP-N-acetylneuraminate + GD1b <=> CMP + GT1b |  | 2.4.99.4
0.013 | 0.005 | 0.021 | EC526 | deoxyadenylate kinase | [c]atp + damp <==> adp + dadp | Nucleotide Salvage Pathways | EC-2.7.4.11
0.013 | 0.003 | 0.023 | R01967 | ATP:deoxyguanosine 5\'-phosphotransferase | ATP + Deoxyguanosine <=> ADP + dGMP | Purine metabolism | 2.7.1.113
0.013 | 0.001 | 0.025 | R00552 | L-Arginine iminohydrolase | L-Arginine + H2O <=> L-Citrulline + NH3 | Arginine and proline metabolism | 3.5.3.6
0.013 | 0.001 | 0.025 | EC552 | insosine kinase | [c]atp + ins --> adp + h + imp | Nucleotide Salvage Pathways | EC-2.7.1.73
0.0125 | 0.022 | 0.003 | R00338 | Oxaloacetate acetylhydrolase | Oxaloacetate + H2O <=> Oxalate + Acetate |  | 3.7.1.1
0.0125 | 0.02 | 0.005 | R02026 | O-Acetyl-L-homoserine acetate-lyase (adding methanethiol) | O-Acetyl-L-homoserine + Thiosulfate + Thioredoxin + H+ <=> L-Homocysteine + Sulfite + Oxidized thioredoxin + Acetate | Methionine metabolism | 2.5.1.49
0.0125 | 0.018 | 0.007 | EC145 | phosphoenolpyruvate carboxykinase | [c]atp + oaa --> adp + co2 + pep | Anaplerotic reactions | EC-4.1.1.49
0.0125 | 0.016 | 0.009 | EC030 | deoxyribose-phosphate aldolase | [c]2dr5p --> [NAME] | Alternate Carbon Metabolism | EC-4.1.2.4
0.0125 | 0.016 | 0.009 | [NAME] | phosphopentomutase 2 (deoxyribose) | [c]2dr1p <==> 2dr5p | Alternate Carbon Metabolism | EC-5.4.2.7
0.0125 | 0.014 | 0.011 | [NAME] | Ethanol:NAD+ oxidoreductase | Ethanol + NAD+ <=> Acetaldehyde + NADH + H+ | Glycolysis / Gluconeogenesis | 1.1.1.1         1.1.1.71
0.0125 | 0.011 | 0.014 | R00672 | L-Ornithine racemase | L-Ornithine <=> D-Ornithine | D-Arginine and D-ornithine metabolism | 5.1.1.9         5.1.1.10        5.1.1.12
0.0125 | 0.009 | 0.016 | R00159 | UTP diphosphohydrolase | UTP + H2O <=> UDP + Orthophosphate | Pyrimidine metabolism | 3.6.1.5         3.6.1.39
0.0125 | 0.008 | 0.017 | R01519 | D-Glucono-1,5-lactone lactonohydrolase | D-Glucono-1,5-lactone + H2O <=> D-Gluconic acid | Pentose phosphate pathway | 3.1.1.17
0.0125 | 0.006 | 0.019 | R02739 | alpha-D-Glucose 6-phosphate ketol-isomerase | alpha-D-Glucose 6-phosphate <=> beta-D-Glucose 6-phosphate | Glycolysis / Gluconeogenesis,Pentose phosphate pathway | 5.1.3.15        5.3.1.9
0.0125 | 0.006 | 0.019 | R00458 | N6-Acyl-L-lysine amidohydrolase | N6-Acetyl-L-lysine + H2O <=> Acetate + L-Lysine | Lysine degradation | 3.5.1.17
0.012 | 0.024 | 0 | R02300 | S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) | 5-Formyltetrahydrofolate <=> 5,10-Methenyltetrahydrofolate + H2O | One carbon pool by folate | 2.1.2.10
0.012 | 0.022 | 0.002 | R00676 | L-Tryptophan:NADP+ oxidoreductase (deaminating) | L-Tryptophan + NADP+ + H2O <=> Indolepyruvate + NH3 + NADPH + H+ |  | 1.4.1.19
0.012 | 0.016 | 0.008 | R01604 | 3-Oxopropanoate:NAD+ oxidoreductase | 3-Oxopropanoate + NAD+ + H2O <=> Malonate + NADH + H+ | beta-Alanine metabolism | 1.2.1.15
0.012 | 0.015 | 0.009 | R00280 | Nitric-oxide:(acceptor) oxidoreductase | Acceptor + 2 Nitric oxide + 2 H2O <=> Reduced acceptor + 2 Nitrite |  | 1.7.2.1
0.012 | 0.014 | 0.01 | R00602 | Hydorogen-peroxide:hydrogen-peroxide oxidoreductase | Methanol + H2O2 <=> Formaldehyde + 2 H2O | Methane metabolism | 1.11.1.6        1.11.1.7
0.012 | 0.012 | 0.012 | R06154 | methylamine:oxygen oxidoreductase (deaminating) (copper-containing) | Methylamine + Oxygen + H2O <=> Formaldehyde + NH3 + H2O2 |  | 1.4.3.6
0.012 | 0.012 | 0.012 | R00606 | Methylamine:(acceptor) oxidoreductase (deaminating) | Methylamine + H2O <=> Formaldehyde + NH3 + 2 H+ | Methane metabolism | 1.4.99.3
0.012 | 0.009 | 0.015 | R06977 | L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase | L-Glutamate + L-Aspartate 4-semialdehyde <=> 2-Oxoglutarate + L-2,4-Diaminobutanoate | Glycine, serine and threonine metabolism | 2.6.1.76
0.012 | 0.009 | 0.015 | R00791 | Nitrite:ferredoxin oxidoreductase | Nitrite + H2O + 2 Oxidized ferredoxin <=> Nitrate + 2 Reduced ferredoxin | Nitrogen metabolism | 1.7.7.2
0.012 | 0.009 | 0.015 | R00473 | (3S)-3-Carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase | (3S)-3-Carboxy-3-hydroxypropanoyl-CoA <=> Acetyl-CoA + Glyoxylate | Glyoxylate and dicarboxylate metabolism | 4.1.3.24
0.012 | 0.006 | 0.018 | R01961 | ATP:D-glucosamine phosphotransferase | ATP + D-Glucosamine <=> ADP + D-Glucosamine 6-phosphate | Aminosugars metabolism | 2.7.1.1         2.7.1.8
0.012 | 0.005 | 0.019 | R01230 | Xanthosine-5\'-phosphate:ammonia ligase (AMP-forming) | ATP + Xanthosine 5\'-phosphate + NH3 <=> AMP + Pyrophosphate + GMP | Purine metabolism | 6.3.4.1
0.012 | 0.004 | 0.02 | R00924 | Propanoyl-CoA:(acceptor) 2,3-oxidoreductase | Propanoyl-CoA + FAD <=> FADH2 + Propenoyl-CoA | beta-Alanine metabolism | 1.3.99.3
0.012 | 0.002 | 0.022 | R00088 | ATP aminohydrolase | ATP + H2O <=> ITP + NH3 |  | 3.5.4.18
0.012 | 0.002 | 0.022 | EC548 | deoxyguanylate [NAME] (dGMP:ATP) | [c]atp + dgmp <==> adp + dgdp | Nucleotide Salvage Pathways | EC-2.7.4.8
0.012 | 0.001 | 0.023 | R06540 | leucocyanidin,2-oxoglutarate:oxygen oxidoreductase | cis-3,4-Leucopelargonidin + 2-Oxoglutarate + Oxygen <=> Dihydrokaempferol + Succinate + CO2 + H2O | Flavonoid biosynthesis | 1.14.11.19
0.012 | 0.001 | 0.023 | R03123 | cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase | cis-3,4-Leucopelargonidin + NADP+ <=> Dihydrokaempferol + NADPH + H+ | Flavonoid biosynthesis | 1.1.1.219
0.0115 | 0.023 | 0 | R07211 | L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating) | L-Phenylalanine + Tetrahydrobiopterin + Oxygen <=> L-Tyrosine + 4a-Hydroxytetrahydrobiopterin |  | 1.14.16.1
0.0115 | 0.023 | 0 | R03051 | 2,3-Dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) | 2-Acetolactate + NADPH + H+ <=> 2,3-Dihydroxy-3-methylbutanoate + NADP+ | Pantothenate and CoA biosynthesis | 1.1.1.86
0.0115 | 0.023 | 0 | R01209 | 2,3-Dihydroxy-3-methylbutanoate hydro-lyase | 2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O | Pantothenate and CoA biosynthesis | 4.2.1.9
0.0115 | 0.014 | 0.009 | EC467 | glycerate kinase | [c]atp + glyc-R --> 3pg + adp + h | Glyoxylate Metabolism | EC-2.7.1.31
0.0115 | 0.012 | 0.011 | R00017 | Ferrocytochrome-c:hydrogen-peroxide oxidoreductase | H2O2 + 2 Ferrocytochrome c <=> 2 Ferricytochrome c + 2 H2O |  | 1.11.1.5
0.0115 | 0.01 | 0.013 | R01872 | Quinate:NAD+ 5-oxidoreductase | Quinate + NAD+ <=> 3-Dehydroquinate + NADH + H+ | Phenylalanine, tyrosine and tryptophan biosynthesis | 1.1.1.24        1.1.1.282
0.0115 | 0.009 | 0.014 | R04188 | [NAME] aminotransferase | [NAME] <=> (S)-Methylmalonate semialdehyde + L-Glutamate | [NAME], leucine and isoleucine degradation | 2.6.1.22
0.0115 | 0.009 | 0.014 | R04187 | L-Alanine:3-oxopropanoate aminotransferase | L-Alanine + (S)-Methylmalonate semialdehyde <=> Pyruvate + L-3-Amino-isobutanoate | [NAME], leucine and isoleucine degradation | 2.6.1.18
0.0115 | 0.008 | 0.015 | R02570 | Succinyl-CoA:dihydrolipoamide S-succinyltransferase | Succinyl-CoA + Dihydrolipoamide <=> CoA + S-Succinyldihydrolipoamide | Citrate cycle (TCA cycle) | 2.3.1.61
0.0115 | 0.005 | 0.018 | R02732 | ATP:D-fructose-6-phosphate 2-phosphotransferase | ATP + beta-D-Fructose 6-phosphate <=> ADP + beta-D-Fructose 2,6-bisphosphate | Fructose and mannose metabolism | 2.7.1.105
0.0115 | 0.003 | 0.02 | R00122 | ATP pyrophosphohydrolase | ADP + H2O <=> AMP + Orthophosphate | Purine metabolism | 3.6.1.5
0.0115 | 0.001 | 0.022 | R01308 |  | 4-Hydroxybenzoate + Acetate + NADH + H+ <=> 4-Coumarate + 2 H2O + NAD+ | Phenylalanine metabolism
0.011 | 0.022 | 0 | R03198 | (R)-4-dehydropantoate:NAD+ 4-oxidoreductase | (R)-4-Dehydropantoate + NAD+ + H2O <=> (R)-3,3-Dimethylmalate + NADH + H+ | Pantothenate and CoA biosynthesis | 1.2.1.33
0.011 | 0.022 | 0 | R02471 |  | (R)-Pantoate + NAD+ <=> (R)-4-Dehydropantoate + NADH + H+ | Pantothenate and CoA biosynthesis | 1.1.1.106
0.011 | 0.022 | 0 | R01211 | (R)-3,3-Dimethylmalate:NAD+ oxidoreductase (decarboxylating) | (R)-3,3-Dimethylmalate + NAD+ <=> 3-Methyl-2-oxobutanoic acid + CO2 + NADH | Pantothenate and CoA biosynthesis | 1.1.1.84
0.011 | 0.015 | 0.007 | [NAME] | Ethanol:NADP+ oxidoreductase | Ethanol + NADP+ <=> Acetaldehyde + NADPH | Glycolysis / Gluconeogenesis | 1.1.1.2         1.1.1.71
0.011 | 0.01 | 0.012 | [NAME] | alpha,beta-Dihydroxyethyl-TPP:formaldehyde glycolaldehydetransferase | alpha,beta-Dihydroxyethyl-TPP + Formaldehyde <=> Thiamin diphosphate + Glycerone |  | 2.2.1.3
0.011 | 0.01 | 0.012 | R03232 | Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase | Protein N(pi)-phospho-L-histidine + D-Fructose <=> Protein histidine + D-Fructose 1-phosphate | Fructose and mannose metabolism | 2.7.1.69
0.011 | 0.009 | 0.013 | R02664 |  | 2-Phospho-D-glycerate + ATP <=> 2,3-Bisphospho-D-glycerate + ADP | Glycolysis / Gluconeogenesis | 2.7.2.-
0.011 | 0.007 | 0.015 | R01698 | Dihydrolipoamide:NAD+ oxidoreductase | Dihydrolipoamide + NAD+ <=> Lipoamide + NADH | Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle) | 1.8.1.4
0.011 | 0.006 | 0.016 | R00806 | UDPglucose:D-fructose 2-alpha-D-glucosyltransferase | UDP-glucose + D-Fructose <=> UDP + Sucrose | Starch and sucrose metabolism | 2.4.1.13
0.011 | 0.004 | 0.018 | [NAME] | Cellobiose:orthophosphate alpha-D-glucosyltransferase | Cellobiose + Orthophosphate <=> D-Glucose 1-phosphate + D-Glucose | Starch and sucrose metabolism | 2.4.1.20
0.011 | 0.003 | 0.019 | R02327 | dCTP:uridine 5\'-phosphotransferase | dCTP + Uridine <=> dCDP + UMP | Pyrimidine metabolism | 2.7.1.48
0.011 | 0.003 | 0.019 | R02143 | Xanthosine ribohydrolase | [NAME] <=> Xanthine + D-Ribose | Purine metabolism | 3.2.2.1
0.011 | 0.003 | 0.019 | [NAME] | beta-D-Glucose:NAD+ 1-oxoreductase | beta-D-Glucose + NAD+ <=> D-Glucono-1,5-lactone + NADH + H+ | Pentose phosphate pathway | 1.1.1.47
0.011 | 0.002 | 0.02 | R00123 | ADP aminohydrolase | ADP + H2O <=> IDP + NH3 |  | 3.5.4.7
0.011 | 0.001 | 0.021 | R01880 | dGTP:uridine 5\'-phosphotransferase | dGTP + Uridine <=> dGDP + UMP | Pyrimidine metabolism | 2.7.1.48
0.0105 | 0.02 | 0.001 | R00675 | L-Tryptophan:NAD+ oxidoreductase (deaminating) | L-Tryptophan + NAD+ + H2O <=> Indolepyruvate + NH3 + NADH + H+ |  | 1.4.1.19
0.0105 | 0.018 | 0.003 | EC705 | acetyl-CoA synthetase | [c]ac + atp + coa --> accoa + amp + ppi | Pyruvate metabolism | EC-6.2.1.1
0.0105 | 0.01 | 0.011 | R02703 | D-Mannitol-1-phosphate:NAD+ 5-oxidoreductase | D-Mannitol 1-phosphate + NAD+ <=> beta-D-Fructose 6-phosphate + NADH | Fructose and mannose metabolism | 1.1.1.17
0.0105 | 0.009 | 0.012 | R03527 | D-Glucoside glucohydrolase | D-Glucoside + H2O <=> [NAME] + alpha-D-Glucose | Starch and sucrose metabolism | 3.2.1.21
0.0105 | 0.009 | 0.012 | R03526 | UDPglucose:phenol beta-D-glucosyltransferase | UDP-glucose + [NAME] <=> UDP + D-Glucoside | Starch and sucrose metabolism | 2.4.1.35
0.0105 | 0.007 | 0.014 | R03294 | trans-4-Hydroxy-L-proline:NAD+ oxidoreductase | trans-4-Hydroxy-L-proline + FAD <=> L-1-Pyrroline-3-hydroxy-5-carboxylate + FADH2 | Arginine and proline metabolism | 1.5.1.12
0.0105 | 0.006 | 0.015 | R00557 | L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) | L-Arginine + Oxygen + NADPH <=> Nitric oxide + L-Citrulline + NADP+ | Arginine and proline metabolism | 1.14.13.39
0.0105 | 0.005 | 0.016 | R01521 | beta-D-Glucose:NADP+ 1-oxoreductase | beta-D-Glucose + NADP+ <=> D-Glucono-1,5-lactone + NADPH + H+ | Pentose phosphate pathway | 1.1.1.47
0.0105 | 0.004 | 0.017 | R03777 | Octanoyl-CoA:oxygen 2-oxidoreductase | Octanoyl-CoA + FAD <=> trans-Oct-2-enoyl-CoA + FADH2 | Fatty acid metabolism | 1.3.3.6         1.3.99.3        1.3.99.13       1.3.99.-
0.0105 | 0.004 | 0.017 | R03776 | trans-Oct-2-enoyl-CoA reductase | Octanoyl-CoA + NADP+ <=> trans-Oct-2-enoyl-CoA + NADPH + H+ | Fatty acid elongation in mitochondria | 1.3.1.38
0.0105 | 0.004 | 0.017 | R01441 | ATP:cellobiose 6-phosphotransferase | ATP + Cellobiose <=> ADP + 6-Phospho-beta-D-glucosyl-(1,4)-D-glucose |  | 2.7.1.85
0.0105 | 0.004 | 0.017 | R00839 | 6-Phospho-beta-D-glucosyl-(1,4)-D-gluxose glucohydrolase | 6-Phospho-beta-D-glucosyl-(1,4)-D-glucose + H2O <=> D-Glucose + D-Glucose 6-phosphate |  | 3.2.1.86
0.0105 | 0.001 | 0.02 | R00279 | D-Glutamate(D-aspartate):oxygen oxidoreductase (deaminating) | D-Glutamate + H2O + Oxygen <=> 2-Oxoglutarate + NH3 + H2O2 | D-Glutamine and D-glutamate metabolism | 1.4.3.7         1.4.3.15
0.01 | 0.02 | 0 | R07212 | L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase(3-hydroxylating) | L-Tyrosine + Tetrahydrobiopterin + Oxygen <=> 3,4-Dihydroxy-L-phenylalanine + 4a-Hydroxytetrahydrobiopterin |  | 1.14.16.2
0.01 | 0.02 | 0 | R05704 | glycine:acceptor oxidoreductase (hydrogen-cyanide-forming) | Glycine + 2 Acceptor <=> Hydrogen cyanide + CO2 + 2 Reduced acceptor |  | 1.4.99.5
0.01 | 0.02 | 0 | R01653 |  | 10-Formyltetrahydrofolate + Orthophosphate + ADP <=> 5-Formyltetrahydrofolate + ATP + H2O | One carbon pool by folate
0.01 | 0.02 | 0 | R01199 | 2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating) | Oxidized ferredoxin + 2-Oxobutanoate + CoA <=> Reduced ferredoxin + Propanoyl-CoA + CO2 | Propanoate metabolism | 1.2.7.1         1.2.7.2
0.01 | 0.019 | 0.001 | EC183 | Proline dehydrogenase | [c]fad + pro-L --> 1pyr5c + fadh2 + h | Arginine and Proline Metabolism | EC-1.5.99.8
0.01 | 0.015 | 0.005 | R00297 | (R)-2-Hydroxy-acid:(acceptor) 2-oxidoreductase | (R)-Lactate + Acceptor <=> Pyruvate + Reduced acceptor |  | 1.1.99.6
0.01 | 0.009 | 0.011 | R02084 | succinyl-CoA:3-hydroxy-3-methylglutarate CoA-transferase | Succinyl-CoA + 3-Hydroxy-3-methylglutarate <=> Succinate + (S)-3-Hydroxy-3-methylglutaryl-CoA |  | 2.8.3.13
0.01 | 0.009 | 0.011 | R02083 | (S)-3-Hydroxy-3-methylglutaryl-CoA hydrolase | (S)-3-Hydroxy-3-methylglutaryl-CoA + H2O <=> CoA + 3-Hydroxy-3-methylglutarate |  | 3.1.2.5
0.01 | 0.009 | 0.011 | R00281 | NADH:(quinone-acceptor) oxidoreductase | Acceptor + NADH + H+ <=> Reduced acceptor + NAD+ |  | 1.6.99.3        1.6.99.5
0.01 | 0.008 | 0.012 | R01700 | 2-Oxoglutarate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) | 2-Oxoglutarate + Lipoamide <=> S-Succinyldihydrolipoamide + CO2 |  | 1.2.4.2
0.01 | 0.007 | 0.013 | R02849 | ITP:D-hexose 6-phosphotransferase | ITP + D-Hexose <=> IDP + D-Hexose 6-phosphate |  | 2.7.1.1
0.01 | 0.007 | 0.013 | R02848 | ATP:D-hexose 6-phosphotransferase | ATP + D-Hexose <=> ADP + D-Hexose 6-phosphate |  | 2.7.1.1
0.01 | 0.005 | 0.015 | R03001 | D-Methionine:pyruvate aminotransferase | D-Methionine + Pyruvate <=> 4-Methylthio-2-oxobutanoic acid + L-Alanine |  | 2.6.1.41
0.01 | 0.005 | 0.015 | R01171 | Butanoyl-CoA:(acceptor) 2,3-oxidoreductase; Butanoyl-CoA:NAD+ trans-2-oxidoreductase | Butanoyl-CoA + NAD+ <=> Crotonoyl-CoA + NADH + H+ | Butanoate metabolism | 1.3.1.44        1.3.99.2
0.01 | 0.005 | 0.015 | EC556 | Nucleoside triphosphate pyrophosphorylase (datp) | [c]datp + h2o --> damp + h + ppi | Nucleotide Salvage Pathways
0.01 | 0 | 0.02 | R01298 | 4-hydroxybenzoate,NADH:oxygen oxidoreductase (3-hydroxylating) | 4-Hydroxybenzoate + Oxygen + NADPH + H+ <=> 3,4-Dihydroxybenzoate + NADP+ + H2O | Benzoate degradation via hydroxylation,2,4-Dichlorobenzoate degradation | 1.14.13.2       1.14.13.33
0.0095 | 0.019 | 0 | R03524 | L-cysteine hydrogen-sulfide-lyase (adding HCN) | L-Cysteine + Hydrogen cyanide <=> Hydrogen sulfide + 3-Cyano-L-alanine |  | 4.4.1.9
0.0095 | 0.017 | 0.002 | EC275 | fumarate reductase | [c]2dmmql8 + fum --> 2dmmq8 + succ | Citrate Cycle (TCA) | [NAME]
0.0095 | 0.016 | 0.003 | R04942 | L-Serine hydro-lyase (adding homocysteine) | L-Serine + Selenohomocysteine <=> Selenocystathionine + H2O | Selenoamino acid metabolism | 4.2.1.22
0.0095 | 0.016 | 0.003 | R04941 | [NAME] (deaminating) | [NAME] <=> Selenohomocysteine + NH3 + Pyruvate | Selenoamino acid metabolism | 4.4.1.8
0.0095 | 0.016 | 0.003 | R02573 | Trimethylsulfonium:tetrahydrofolate N-methyltransferase | Trimethylsulfonium + Tetrahydrofolate <=> Dimethyl sulfide + 5-Methyltetrahydrofolate | One carbon pool by folate | 2.1.1.19
0.0095 | 0.016 | 0.003 | R02572 | S-Adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase | S-Adenosyl-L-methionine + Dimethyl sulfide <=> S-Adenosyl-L-homocysteine + Trimethylsulfonium |  | 2.1.1.96
0.0095 | 0.015 | 0.004 | R03140 | D-Ribulose 1,5-bisphosphate carboxy-lyase (dimerizing) | D-Ribulose 1,5-bisphosphate + Oxygen <=> 3-Phospho-D-glycerate + 2-Phosphoglycolate | Glyoxylate and dicarboxylate metabolism | 4.1.1.39
0.0095 | 0.015 | 0.004 | EC053 | Phosphoglycolate phosphatase | [c]2pglyc + h2o --> glyclt + pi | Alternate Carbon Metabolism | EC-3.1.3.18
0.0095 | 0.013 | 0.006 | [NAME] | mannose-6-phosphate isomerase | [c]man6p <==> f6p | Alternate Carbon Metabolism | EC-5.3.1.8
0.0095 | 0.012 | 0.007 | R00705 | 3-Oxopropanoate:NAD+ oxidoreductase (decarboxylating, CoA-acetylating) | 3-Oxopropanoate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+ | Inositol metabolism,Alanine and aspartate metabolism,beta-Alanine metabolism,Propanoate metabolism | 1.2.1.18        1.2.1.27
0.0095 | 0.009 | 0.01 | R00706 | 3-Oxopropanoate:NADP+ oxidoreductase (decarboxylating, CoA-acetylating) | 3-Oxopropanoate + CoA + NADP+ <=> Acetyl-CoA + CO2 + NADPH + H+ | Inositol metabolism,Alanine and aspartate metabolism,beta-Alanine metabolism,Propanoate metabolism | 1.2.1.18
0.0095 | 0.008 | 0.011 | R02731 | D-Fructose-2,6-bisphosphate 2-phosphohydrolase | beta-D-Fructose 2,6-bisphosphate + H2O <=> beta-D-Fructose 6-phosphate + Orthophosphate | Fructose and mannose metabolism | 3.1.3.46
0.0095 | 0.008 | 0.011 | R00475 | (S)-2-Hydroxy-acid:oxygen 2-oxidoreductase | Glycolate + Oxygen <=> Glyoxylate + H2O2 | Glyoxylate and dicarboxylate metabolism | 1.1.3.15
0.0095 | 0.004 | 0.015 | R00011 | Mn(II):hydrogen-peroxide oxidoreductase | 2 Manganese + 2 H2O <=> H2O2 + 2 Manganese + 2 H+ |  | 1.11.1.13
0.0095 | 0 | 0.019 | R00728 | L-Tyrosine phenol-lyase (deaminating) | L-Tyrosine + H2O <=> Phenol + Pyruvate + NH3 | Tyrosine metabolism,Nitrogen metabolism | 4.1.99.2
0.009 | 0.018 | 0 | R00650 | S-Adenosyl-L-methionine:L-homocysteine S-methyltransferase | S-Adenosyl-L-methionine + L-Homocysteine <=> S-Adenosyl-L-homocysteine + L-Methionine | Methionine metabolism | 2.1.1.10
0.009 | 0.015 | 0.003 | R01523 | ATP:D-ribulose-5-phosphate 1-phosphotransferase | ATP + D-Ribulose 5-phosphate <=> ADP + D-Ribulose 1,5-bisphosphate | Carbon fixation | 2.7.1.19
0.009 | 0.014 | 0.004 | EC037 | fructose-1-phosphate kinase | [c]atp + f1p --> adp + fdp + h | Alternate Carbon Metabolism | EC-2.7.1.56
0.009 | 0.01 | 0.008 | R01354 | Propanoate:CoA ligase (AMP-forming) | ATP + Propanoate <=> Pyrophosphate + Propinol adenylate | Propanoate metabolism | 6.2.1.1         6.2.1.17
0.009 | 0.01 | 0.008 | R00926 | Propinol adenylate:CoA ligase (AMP-forming) | Propinol adenylate + CoA <=> AMP + Propanoyl-CoA | Propanoate metabolism | 6.2.1.1         6.2.1.17
0.009 | 0.007 | 0.011 | R03173 | 2-Methylbutanoyl-CoA:(acceptor) oxidoreductase | 2-Methylbutanoyl-CoA + Acceptor <=> 2-Methylbut-2-enoyl-CoA + Reduced acceptor |  | 1.3.99.12
0.009 | 0.005 | 0.013 | R07171 | NADH:oxygen oxidoreductase | NADH + H+ + Oxygen <=> NAD+ + H2O2 |  | 1.6.3.1
0.009 | 0.005 | 0.013 | R00305 | D-Glucose:(pyrroloquinone-quinone) 1-oxidoreductase | D-Glucose + Acceptor <=> D-Glucono-1,5-lactone + Reduced acceptor | Pentose phosphate pathway | 1.1.99.10
0.009 | 0.004 | 0.014 | R02206 | L-Pipecolate:(acceptor) 1,6-oxidoreductase | L-Pipecolate + Acceptor <=> 2,3,4,5-Tetrahydropyridine-2-carboxylate + Reduced acceptor |  | 1.5.99.3
0.009 | 0.004 | 0.014 | R02205 | L-Pipecolate:(acceptor) 1,6-oxidoreductase | L-Pipecolate + FAD <=> FADH2 + 2,3,4,5-Tetrahydropyridine-2-carboxylate | Lysine degradation | 1.5.99.3
0.009 | 0.003 | 0.015 | R01282 |  | Palmitoyl-CoA + Acceptor <=> trans-Hexadec-2-enoyl-CoA + Reduced acceptor
0.009 | 0.001 | 0.017 | R00737 | L-Tyrosine ammonia-lyase | L-Tyrosine <=> 4-Coumarate + NH3 | Tyrosine metabolism | 4.3.1.5
0.0085 | 0.017 | 0 | R01090 | L-Leucine:2-oxoglutarate aminotransferase | L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate | [NAME], leucine and isoleucine degradation,[NAME], leucine and isoleucine biosynthesis | 2.6.1.6         2.6.1.42
0.0085 | 0.017 | 0 | R01078 | [NAME]:sulfur sulfurtransferase | Dethiobiotin + Sulfur <=> Biotin | Biotin metabolism | 2.8.1.6
0.0085 | 0.017 | 0 | EC300 | [NAME] synthase (ala-L producing) | [c]cys-L + dtbt <==> ala-L + btn + (2) h | Cofactor and Prosthetic Group Biosynthesis
0.0085 | 0.012 | 0.005 | R03248 | 2,5-Diaminopentanoate:2-oxoglutarate aminotransferase | [NAME] <=> 5-Amino-2-oxopentanoic acid + L-Glutamate |  | 2.6.1.8
0.0085 | 0.009 | 0.008 | R02164 | Succinate:ubiquinone oxidoreductase | Ubiquinone + Succinate <=> Ubiquinol + Fumarate | Citrate cycle (TCA cycle) | 1.3.5.1
0.0085 | 0.007 | 0.01 | R00364 | Glycine:ferricytochrome-c oxidoreductase (deaminating) | Glycine + H2O + 2 Ferricytochrome c <=> Glyoxylate + NH3 + 2 Ferrocytochrome c | Glycine, serine and threonine metabolism | 1.4.2.1
0.0085 | 0.007 | 0.01 | EC560 | Nucleoside triphosphate pyrophosphorylase (dgtp) | [c]dgtp + h2o --> dgmp + h + ppi | Nucleotide Salvage Pathways
0.0085 | 0.006 | 0.011 | R00113 | NADPH:hydrogen-peroxide oxidoreductase | H2O2 + NADPH + H+ <=> NADP+ + 2 H2O |  | 1.11.1.2
0.0085 | 0.006 | 0.011 | R00081 | Ferrocytochrome-c:oxygen oxidoreductase | Oxygen + 4 Ferrocytochrome c <=> 4 Ferricytochrome c + 2 H2O |  | 1.9.3.1
0.0085 | 0.005 | 0.012 | R00028 | alpha-D-Glucoside glucohydrolase | Maltose + H2O <=> 2 alpha-D-Glucose | Starch and sucrose metabolism | 3.2.1.20
0.0085 | 0.002 | 0.015 | R07147 | D-glucose:NADP+ 1-oxidoreductase | D-Glucose + NADP+ <=> D-Glucono-1,5-lactone + NADPH + H+ |  | 1.1.1.119
0.0085 | 0.002 | 0.015 | R00961 | IDP diphosphohydrolase | IDP + H2O <=> IMP + Orthophosphate | Purine metabolism | 3.6.1.5         3.6.1.6
0.0085 | 0.002 | 0.015 | R00648 | L-Methionine:oxygen oxidoreductase (deaminating) | L-Methionine + H2O + Oxygen <=> 4-Methylthio-2-oxobutanoic acid + NH3 + H2O2 | Methionine metabolism | 1.4.3.2
0.0085 | 0 | 0.017 | [NAME] | L-aspartate:NAD+ oxidoreductase (deaminating) | L-Aspartate + NAD+ <=> Iminoaspartate + NADH + H+ | Nicotinate and nicotinamide metabolism | 1.4.1.21
0.008 | 0.016 | 0 | R03134 | O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase | O-Acetyl-L-serine + Pyrazole <=> 3-(Pyrazol-1-yl)-L-alanine + Acetate |  | 2.5.1.51
0.008 | 0.016 | 0 | R02378 | L-Serine hydro-lyase (adding pyrazole) | L-Serine + Pyrazole <=> 3-(Pyrazol-1-yl)-L-alanine + H2O |  | 4.2.1.50
0.008 | 0.016 | 0 | EC281 | Malate dehydrogenase (ubiquinone 8 as acceptor) | [c]mal-L + q8 --> oaa + q8h2 | Citrate Cycle (TCA) | EC-1.1.99.16
0.008 | 0.014 | 0.002 | R00719 | ITP diphosphohydrolase | ITP + H2O <=> IDP + Orthophosphate | Purine metabolism | 3.6.1.5
0.008 | 0.011 | 0.005 | R00684 | L-Tryptophan:2-oxoglutarate aminotransferase | L-Tryptophan + 2-Oxoglutarate <=> Indolepyruvate + L-Glutamate | Tryptophan metabolism | 2.6.1.27
0.008 | 0.009 | 0.007 | R01558 | Oxalate:CoA ligase (AMP-forming) | ATP + Oxalate + CoA <=> AMP + Pyrophosphate + Oxalyl-CoA | Glyoxylate and dicarboxylate metabolism | 6.2.1.8
0.008 | 0.009 | 0.007 | R00678 | L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) | L-Tryptophan + Oxygen <=> L-Formylkynurenine | Tryptophan metabolism | 1.13.11.11      1.13.11.52
0.008 | 0.007 | 0.009 | EC016 | alcohol dehydrogenase (glycerol) | [c]glyald + h + nadh <==> glyc + nad | Alternate Carbon Metabolism | EC-1.1.1.1
0.008 | 0.006 | 0.01 | R02034 | 6-Phospho-D-gluconate:NADP+ 2-oxidoreductase | 6-Phospho-D-gluconate + NADP+ <=> 6-Phospho-2-dehydro-D-gluconate + NADPH + H+ | Pentose phosphate pathway,Glutathione metabolism | 1.1.1.43
0.008 | 0.005 | 0.011 | R04095 | 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase | 3-Methylbutanoyl-CoA + FAD <=> 3-Methylcrotonyl-CoA + FADH2 | [NAME], leucine and isoleucine degradation | 1.3.99.3        1.3.99.10
0.008 | 0.004 | 0.012 | R01600 | ATP:D-glucose 6-phosphotransferase | ATP + beta-D-Glucose <=> ADP + beta-D-Glucose 6-phosphate | Glycolysis / Gluconeogenesis | 2.7.1.1         2.7.1.2
0.008 | 0.004 | 0.012 | R01059 | ATP:D-glyceraldehyde 3-phosphotransferase | ATP + D-Glyceraldehyde <=> ADP + (2R)-2-Hydroxy-3-(phosphonooxy)-propanal | Fructose and mannose metabolism | 2.7.1.28
0.008 | 0.003 | 0.013 | R05723 | leucocyanidin,2-oxoglutarate:oxygen oxidoreductase | Leucocyanidin + 2-Oxoglutarate + Oxygen <=> Taxifolin + Succinate + CO2 + H2O | Flavonoid biosynthesis | 1.14.11.19
0.008 | 0.003 | 0.013 | R03636 | Leucocyanidin:NADP+ 4-oxidoreductase; cis-3,4-Leucopelargonidin:NADP+ 4-oxidoreductase | Leucocyanidin + NADP+ <=> [NAME] | Flavonoid biosynthesis | 1.1.1.219
0.008 | 0.003 | 0.013 | R00877 | D-Mannose ketol-isomerase | D-Mannose <=> D-Fructose | Fructose and mannose metabolism | 5.3.1.7
0.008 | 0.003 | 0.013 | [NAME] | Sucrose:(acceptor) 3-oxidoreductase | Sucrose + Acceptor <=> 3-Ketosucrose + Reduced acceptor |  | 1.1.99.13
0.008 | 0.003 | 0.013 | R00807 | Sucrose:(acceptor) 3-oxidoreductase | Sucrose + FAD <=> 3-Ketosucrose + FADH2 | Starch and sucrose metabolism | 1.1.99.13
0.008 | 0.002 | 0.014 | EC598 | purine-nucleoside phosphorylase (Deoxyinosine) | [c]din + pi <==> 2dr1p + hxan | Nucleotide Salvage Pathways | EC-2.4.2.1
0.008 | 0.002 | 0.014 | [NAME] | Deoxyadenosine deaminase | [c]dad-2 + h + h2o --> din + nh4 | Nucleotide Salvage Pathways
0.008 | 0 | 0.016 | R00491 | L-Aspartate racemase | L-Aspartate <=> D-Aspartate | Alanine and aspartate metabolism | 5.1.1.13
0.008 | 0 | 0.016 | R00359 | D-Aspartate:oxygen oxidoreductase (deaminating) | D-Aspartate + H2O + Oxygen <=> Oxaloacetate + NH3 + H2O2 | Alanine and aspartate metabolism | 1.4.3.1         1.4.3.15
0.008 | 0 | 0.016 | EC007 | L-aspartase | [c]asp-L --> fum + nh4 | Alanine and aspartate metabolism | EC-4.3.1.1
0.0075 | 0.015 | 0 | EC048 | Glycolate oxidase | [c]glyclt + q8 --> glx + q8h2 | Alternate Carbon Metabolism
0.0075 | 0.012 | 0.003 | R01399 | Carbamoyl-phosphate:putrescine carbamoyltransferase | Carbamoyl phosphate + Putrescine <=> Orthophosphate + N-Carbamoylputrescine |  | 2.1.3.6
0.0075 | 0.011 | 0.004 | R00522 | Oxalate carboxy-lyase | Oxalate <=> Formate + CO2 | Glyoxylate and dicarboxylate metabolism | 4.1.1.2
0.0075 | 0.004 | 0.011 | R04096 | 3-Methylbutanoyl-CoA:(acceptor) oxidoreductase | 3-Methylbutanoyl-CoA + Acceptor <=> 3-Methylcrotonyl-CoA + Reduced acceptor |  | 1.3.99.10
0.0075 | 0.002 | 0.013 | R01278 | trans-Hexadec-2-enoyl-CoA reductase | Palmitoyl-CoA + NADP+ <=> trans-Hexadec-2-enoyl-CoA + NADPH + H+ | Fatty acid elongation in mitochondria | 1.3.1.38
0.0075 | 0.001 | 0.014 | R01296 | 4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating) | 4-Hydroxybenzoate + Oxygen + NADH + H+ <=> 3,4-Dihydroxybenzoate + NAD+ + H2O | Benzoate degradation via hydroxylation,2,4-Dichlorobenzoate degradation | 1.14.13.33
0.007 | 0.014 | 0 | EC580 | [NAME] (ATP:thymidine) | [c]atp + thymd --> adp + dtmp + h | Nucleotide Salvage Pathways | EC-2.7.1.21
0.007 | 0.013 | 0.001 | EC451 | fructose-bisphosphatase | [c]fdp + h2o --> f6p + pi | Glycolysis/Gluconeogenesis | EC-3.1.3.11
0.007 | 0.013 | 0.001 | EC280 | malate dehydrogenase | [c]mal-L + nad <==> h + nadh + oaa | Citrate Cycle (TCA) | EC-1.1.1.37
0.007 | 0.013 | 0.001 | EC090 | mannitol-1-phosphate 5-dehydrogenase | [c]mnl1p + nad <==> f6p + h + nadh | Alternate Carbon Metabolism | EC-1.1.1.17
0.007 | 0.012 | 0.002 | R00360 | (S)-Malate:oxygen oxidoreductase | (S)-Malate + Oxygen <=> Oxaloacetate + H2O2 | Pyruvate metabolism | 1.1.3.3
0.007 | 0.012 | 0.002 | EC131 | Hydroxypyruvate reductase (NADPH) | [c]h + hpyr + nadph --> glyc-R + nadp | Alternate Carbon Metabolism
0.007 | 0.011 | 0.003 | EC130 | Hydroxypyruvate reductase (NADH) | [c]h + hpyr + nadh --> glyc-R + nad | Alternate Carbon Metabolism
0.007 | 0.008 | 0.006 | R05724 | nitric oxide, NAD(P)H2:oxygen oxidoreductase | 2 Nitric oxide + 2 Oxygen + NADH + H+ <=> 2 Nitrate + NAD+ |  | 1.14.12.17
0.007 | 0.008 | 0.006 | R01253 | L-proline:(acceptor) oxidoreductase | L-Proline + Acceptor <=> (S)-1-Pyrroline-5-carboxylate + Reduced acceptor | Arginine and proline metabolism | 1.5.99.8
0.007 | 0.007 | 0.007 | R01695 | L-Sorbose:oxygen 5-oxidoreductase | L-Sorbose + Oxygen <=> 5-Dehydro-D-fructose + H2O2 |  | 1.1.3.11
0.007 | 0.007 | 0.007 | EC466 | glyoxalate carboligase | [c](2) glx + h --> 2h3oppan + co2 | Glyoxylate Metabolism | EC-4.1.1.47
0.007 | 0.006 | 0.008 | EC590 | 5'-nucleotidase (dGMP) | [c]dgmp + h2o --> dgsn + pi | Nucleotide Salvage Pathways | EC-3.1.3.5
0.007 | 0.005 | 0.009 | R00655 | L-Methionine racemase | L-Methionine <=> D-Methionine |  | 5.1.1.2
0.007 | 0.004 | 0.01 | [NAME] | D-Glucose 6-sulfate sulfohydrolase | D-Glucose 6-sulfate + H2O <=> beta-D-Glucose + Sulfate | Glycolysis / Gluconeogenesis | 3.1.6.3
0.007 | 0.004 | 0.01 | R00233 | Malonyl-CoA carboxy-lyase | Malonyl-CoA <=> Acetyl-CoA + CO2 | beta-Alanine metabolism,Propanoate metabolism | 4.1.1.9
0.007 | 0.003 | 0.011 | R00090 | NADH:hydrogen-peroxide oxidoreductase | H2O2 + NADH + H+ <=> NAD+ + 2 H2O |  | 1.11.1.1
0.007 | 0.002 | 0.012 | R07172 | NADPH:oxygen oxidoreductase | NADPH + H+ + Oxygen <=> NADP+ + H2O2 |  | 1.6.3.1
0.007 | 0.002 | 0.012 | [NAME] | dUTP:uridine 5\'-phosphotransferase | dUTP + Uridine <=> dUDP + UMP | Pyrimidine metabolism | 2.7.1.48
0.0065 | 0.012 | 0.001 | EC625 | glycerol-3-phosphate dehydrogenase (ubiquinone-8) | [c]glyc3p + q8 --> dhap + q8h2 | Oxidative phosphorylation | EC-1.1.99.5
0.0065 | 0.011 | 0.002 | EC639 | pyruvate oxidase | [c]h2o + pyr + q8 --> ac + co2 + q8h2 | Oxidative phosphorylation | [NAME]
0.0065 | 0.007 | 0.006 | R01557 | Maltose alpha-D-glucosylmutase | Maltose <=> alpha,alpha-Trehalose | Starch and sucrose metabolism | 5.4.99.16
0.0065 | 0.005 | 0.008 | R07394 |  | 2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O <=> 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one + Orthophosphate | Methionine metabolism | 3.1.3.77
0.0065 | 0.005 | 0.008 | R07393 |  | 2,3-Diketo-5-methylthiopentyl-1-phosphate <=> 2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate | Methionine metabolism | 3.1.3.77
0.0065 | 0.005 | 0.008 | R03169 | 2-methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase | 2-Methylbutanoyl-CoA + NAD+ <=> 2-Methylbut-2-enoyl-CoA + NADH + H+ |  | 1.3.1.52
0.0065 | 0.004 | 0.009 | R03920 | ATP:D-fructose 6-phosphotransferase | ATP + beta-D-Fructose <=> ADP + beta-D-Fructose 6-phosphate | Starch and sucrose metabolism | 2.7.1.1         2.7.1.4
0.0065 | 0.004 | 0.009 | R00272 | 2-Oxoglutarate carboxy-lyase | 2-Oxoglutarate <=> Succinate semialdehyde + CO2 |  | 4.1.1.71
0.0065 | 0.004 | 0.009 | R00217 | Oxaloacetate carboxy-lyase | Oxaloacetate <=> Pyruvate + CO2 | Pyruvate metabolism | 4.1.1.3
0.0065 | 0.003 | 0.01 | R03990 | Tetradecanoyl-CoA:(acceptor) 2,3-oxidoreductase | Tetradecanoyl-CoA + FAD <=> trans-Tetradec-2-enoyl-CoA + FADH2 | Fatty acid metabolism | 1.3.3.6         1.3.99.3        1.3.99.13       1.3.99.-
0.0065 | 0.003 | 0.01 | R03989 | trans-Tetradec-2-enoyl-CoA reductase | Tetradecanoyl-CoA + NADP+ <=> trans-Tetradec-2-enoyl-CoA + NADPH + H+ | Fatty acid elongation in mitochondria | 1.3.1.38
0.0065 | 0.003 | 0.01 | R00803 | Sucrose:orthophosphate alpha-D-glucosyltransferase | Sucrose + Orthophosphate <=> D-Fructose + D-Glucose 1-phosphate | Starch and sucrose metabolism | 2.4.1.7
0.0065 | 0.002 | 0.011 | R00406 |  | Succinyl-CoA + (S)-Malate <=> Succinate + (3S)-3-Carboxy-3-hydroxypropanoyl-CoA
0.0065 | 0.001 | 0.012 | EC175 | 4-aminobutyrate transaminase | [c]4abut + akg --> glu-L + sucsal | Arginine and Proline Metabolism | EC-2.6.1.19
0.0065 | 0 | 0.013 | R01245 | Adenosine ribohydrolase | Adenosine + H2O <=> Adenine + D-Ribose | Purine metabolism | 3.2.2.1         3.2.2.7         3.2.2.8
0.006 | 0.011 | 0.001 | EC042 | UDPglucose 4-epimerase | [c]udpg <==> udpgal | Alternate Carbon Metabolism | EC-5.1.3.2
0.006 | 0.01 | 0.002 | [NAME] | D-Cysteine sulfide-lyase (deaminating) | D-Cysteine + H2O <=> Hydrogen sulfide + NH3 + Pyruvate | Cysteine metabolism | 4.4.1.15
0.006 | 0.01 | 0.002 | R00903 | L-2-Amino-3-mercaptopropionic acid racemase | L-Cysteine <=> D-Cysteine | Cysteine metabolism | 5.1.1.10
0.006 | 0.01 | 0.002 | R00581 | L-serine:NAD+ oxidoreductase (deaminating) | L-Serine + NAD+ + H2O <=> Hydroxypyruvate + NH3 + NADH + H+ |  | 1.4.1.7
0.006 | 0.01 | 0.002 | EC051 | Glycerol dehydrogenase | [c]glyc + nad --> dha + h + nadh | Alternate Carbon Metabolism | EC-1.1.1.6
0.006 | 0.007 | 0.005 | R05725 | nitric oxide, [NAME]:oxygen oxidoreductase | 2 Nitric oxide + 2 Oxygen + NADPH + H+ <=> 2 Nitrate + NADP+ |  | 1.14.12.17
0.006 | 0.006 | 0.006 | R06846 | L-quinate:NADP+ 3-oxidoreductase | Quinate + NADP+ <=> 3-Dehydroquinate + NADPH + H+ |  | 1.1.1.282
0.006 | 0.006 | 0.006 | R01696 | L-Sorbose:(acceptor) 5-oxidoreductase | L-Sorbose + Acceptor <=> 5-Dehydro-D-fructose + Reduced acceptor |  | 1.1.99.12
0.006 | 0.005 | 0.007 | R00628 | Acetic-ester acetylhydrolase | Acetic ester + H2O <=> Alcohol + Acetate |  | 3.1.1.6
0.006 | 0.005 | 0.007 | R00627 | Acetyl-CoA:alcohol O-acetyltransferase | Acetyl-CoA + Alcohol <=> CoA + Acetic ester |  | 2.3.1.84
0.006 | 0.005 | 0.007 | EC593 | 5'-nucleotidase (AMP) | [c]amp + h2o --> adn + pi | Nucleotide Salvage Pathways | EC-3.1.3.5
0.006 | 0.003 | 0.009 | R01697 | D-Sorbitol:(acceptor) 1-oxidoreductase | D-Sorbitol + Acceptor <=> L-Sorbose + Reduced acceptor |  | 1.1.99.21
0.006 | 0.003 | 0.009 | R00873 | D-Fructose:(acceptor) 5-oxidoreductase | D-Fructose + Acceptor <=> 5-Dehydro-D-fructose + Reduced acceptor |  | 1.1.99.11
0.006 | 0.003 | 0.009 | EC152 | succinate-semialdehyde dehydrogenase (NAD) | [c]h2o + nad + sucsal --> (2) h + nadh + succ | Arginine and Proline Metabolism | EC-1.2.1.16
0.006 | 0.002 | 0.01 | R07346 | D-glucitol:NADP+ oxidoreductase | D-Sorbitol + NADP+ <=> L-Sorbose + NADPH + H+ |  | 1.1.1.289
0.006 | 0.001 | 0.011 | [NAME] | Decanoyl-CoA:(acceptor) 2,3-oxidoreductase | Decanoyl-CoA + FAD <=> trans-Dec-2-enoyl-CoA + FADH2 | Fatty acid metabolism | 1.3.3.6         1.3.99.3        1.3.99.13       1.3.99.-
0.006 | 0.001 | 0.011 | R04753 | trans-Dec-2-enoyl-CoA reductase | Decanoyl-CoA + NADP+ <=> trans-Dec-2-enoyl-CoA + NADPH + H+ | Fatty acid elongation in mitochondria | 1.3.1.38
0.006 | 0.001 | 0.011 | EC522 | Adenosine deaminase | [c]adn + h + h2o --> ins + nh4 | Nucleotide Salvage Pathways | EC-3.5.4.4
0.006 | 0 | 0.012 | R00720 | Inosine 5\'-triphosphate pyrophosphohydrolase | ITP + H2O <=> IMP + Pyrophosphate | Purine metabolism | 3.6.1.8         3.6.1.19
0.006 | 0 | 0.012 | R00567 | L-Arginine racemase | L-Arginine <=> D-Arginine | D-Arginine and D-ornithine metabolism | 5.1.1.9
0.0055 | 0.011 | 0 | R01267 | L-Asparagine hydro-lyase | L-Asparagine <=> 3-Cyano-L-alanine + H2O | Cyanoamino acid metabolism | 4.2.1.65
0.0055 | 0.009 | 0.002 | R00503 | UDPgalactose:D-glucose 4-beta-D-galactosyltransferase | UDP-D-galactose + D-Glucose <=> UDP + Lactose | Galactose metabolism | 2.4.1.22
0.0055 | 0.008 | 0.003 | R02457 | D-Ornithine:oxygen oxidoreductase (deaminating) | D-Ornithine + H2O + Oxygen <=> 5-Amino-2-oxopentanoic acid + NH3 + H2O2 | D-Arginine and D-ornithine metabolism | 1.4.3.3
0.0055 | 0.007 | 0.004 | R00335 | GTP phosphohydrolase (vesicle-releasing) | GTP + H2O <=> GDP + Orthophosphate | Purine metabolism | 3.6.1.5         3.6.5.1         3.6.5.2         3.6.5.3 3.6.5.4         3.6.5.5         3.6.5.6
0.0055 | 0.006 | 0.005 | R01564 | N,N-Dimethylglycine:oxygen oxidoreductase (demethylating) | N,N-Dimethylglycine + H2O + Oxygen <=> Sarcosine + Formaldehyde + H2O2 |  | 1.5.3.10
0.0055 | 0.005 | 0.006 | R02167 | D-Mannitol-1-phosphate phosphohydrolase | D-Mannitol 1-phosphate + H2O <=> Mannitol + Orthophosphate | Fructose and mannose metabolism | 3.1.3.22
0.0055 | 0.005 | 0.006 | R01694 | L-Sorbose:NADP+ 5-oxidoreductase | L-Sorbose + NADP+ <=> 5-Dehydro-D-fructose + NADPH + H+ |  | 1.1.1.123
0.0055 | 0.005 | 0.006 | R01374 | D-phenylalanine:(acceptor) oxidoreductase (deaminating) | D-Phenylalanine + H2O + Acceptor <=> Phenylpyruvate + NH3 + Reduced acceptor | Phenylalanine metabolism | 1.4.99.1
0.0055 | 0.005 | 0.006 | R00468 | Glyoxylate:NADP+ oxidoreductase (CoA-oxalylating) | Glyoxylate + CoA + NADP+ <=> Oxalyl-CoA + NADPH + H+ | Glyoxylate and dicarboxylate metabolism | 1.2.1.17
0.0055 | 0.004 | 0.007 | R02736 | beta-D-Glucose-6-phosphate:NADP+ 1-oxoreductase | beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+ | Pentose phosphate pathway,Glutathione metabolism | 1.1.1.49
0.0055 | 0.004 | 0.007 | R01022 | Choline:oxygen 1-oxidoreductase | [NAME] <=> [NAME] aldehyde + H2O2 |  | 1.1.3.17
0.0055 | 0.001 | 0.01 | EC174 | succinate-semialdehyde dehydrogenase (NADP) | [c]h2o + nadp + sucsal --> (2) h + nadph + succ | Arginine and Proline Metabolism | EC-1.2.1.16
0.0055 | 0 | 0.011 | R02137 | Cytidine ribohydrolase | Cytidine + H2O <=> Cytosine + D-Ribose | Pyrimidine metabolism | 3.2.2.8
0.0055 | 0 | 0.011 | R01238 | 4-Hydroxybenzoate carboxy-lyase | 4-Hydroxybenzoate <=> Phenol + CO2 | Benzoate degradation via CoA ligation | 4.1.1.61
0.005 | 0.01 | 0 | R00731 | L-Tyrosine:oxygen oxidoreductase | L-Tyrosine + Oxygen <=> 3,4-Dihydroxy-L-phenylalanine + H2O | Tyrosine metabolism | 1.14.18.1
0.005 | 0.01 | 0 | R00589 | L-2-Amino-3-hydroxypropionic acid racemase | L-Serine <=> D-Serine | Glycine, serine and threonine metabolism | 5.1.1.10
0.005 | 0.01 | 0 | EC618 | Trimethylamine N-oxide reductase (menaquinol 8) | [c]h + mql8 + tmao --> h2o + mqn8 + tma | Oxidative phosphorylation
0.005 | 0.01 | 0 | EC439 | D-serine deaminase | [c]ser-D --> nh4 + pyr | Glycine and Serine Metabolism
0.005 | 0.007 | 0.003 | R03121 | Aromatic-amino-acid:glyoxylate aminotransferase | Aromatic amino acid + Glyoxylate <=> Aromatic oxo acid + Glycine |  | 2.6.1.60
0.005 | 0.007 | 0.003 | R03120 | Aromatic-amino-acid:2-oxoglutarate aminotransferase | Aromatic amino acid + 2-Oxoglutarate <=> Aromatic oxo acid + L-Glutamate |  | 2.6.1.57
0.005 | 0.007 | 0.003 | R02559 | NADH:trimethylamine-N-oxide oxidoreductase | Trimethylamine + NAD+ + H2O <=> Trimethylamine N-oxide + NADH + H+ |  | 1.6.6.9
0.005 | 0.007 | 0.003 | R00227 | Acetyl-CoA hydrolase | Acetyl-CoA + H2O <=> CoA + Acetate | Pyruvate metabolism | 3.1.2.1
0.005 | 0.005 | 0.005 | R03936 | Formylkynurenine hydrolase | L-Formylkynurenine + H2O <=> Formylanthranilate + L-Alanine | Tryptophan metabolism | 3.7.1.3
0.005 | 0.005 | 0.005 | R02161 | Ubiquinol:ferricytochrome-c oxidoreductase | Ubiquinol + 2 Ferricytochrome c <=> Ubiquinone + 2 Ferrocytochrome c |  | 1.10.2.2
0.005 | 0.005 | 0.005 | R00988 | N-Formylanthranilate amidohydrolase | Formylanthranilate + H2O <=> Formate + Anthranilate | Tryptophan metabolism | 3.5.1.9
0.005 | 0.005 | 0.005 | R00407 | Succinyl-CoA hydrolase | Succinyl-CoA + H2O <=> CoA + Succinate | Citrate cycle (TCA cycle) | 3.1.2.3
0.005 | 0.003 | 0.007 | [NAME] | Biuret amidohydrolase | Biuret + H2O <=> Urea-1-carboxylate + NH3 | Atrazine degradation | 3.5.1.84
0.005 | 0.003 | 0.007 | R05562 | Biuret amidohydrolase | Biuret + H2O <=> Urea + CO2 + NH3 | Atrazine degradation | 3.5.1.84
0.005 | 0.003 | 0.007 | R03291 | trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase | trans-4-Hydroxy-L-proline + NAD+ <=> L-1-Pyrroline-3-hydroxy-5-carboxylate + NADH + H+ | Arginine and proline metabolism | 1.5.1.2
0.005 | 0.003 | 0.007 | R01277 | hexadecanal:NAD+ oxidoreductase (CoA-acylating) | Hexadecanal + CoA + NAD+ <=> Palmitoyl-CoA + NADH + H+ |  | 1.2.1.42
0.005 | 0.003 | 0.007 | R00774 | Urea:carbon-dioxide ligase (ADP-forming) | ATP + Urea + HCO3- <=> ADP + Orthophosphate + Urea-1-carboxylate | Urea cycle and metabolism of amino groups | 6.3.4.6
0.005 | 0.003 | 0.007 | R00146 |  | alpha-Amino acid + H2O + NADP+ <=> 2-Oxo acid + NH3 + NADPH + H+ | Nitrogen metabolism | 1.4.1.1         1.4.1.2         1.4.1.3         1.4.1.4 1.4.1.5         1.4.1.7         1.4.1.8         1.4.1.9 1.4.1.10        1.4.1.12        1.4.1.15        1.4.1.19 1.4.1.20
0.005 | 0.002 | 0.008 | R06124 |  | alpha-Amino acid + H2O + Oxygen <=> 2-Oxo acid + NH3 + H2O2 | Nitrogen metabolism | 1.4.3.1         1.4.3.2         1.4.3.3         1.4.3.7 1.4.3.11
0.005 | 0.002 | 0.008 | R05882 | UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase | UDP-glucose + Vomilenine <=> UDP + Raucaffricine | Indole and ipecac alkaloid biosynthesis | 2.4.1.219
0.005 | 0.002 | 0.008 | R03703 | Raucaffricine beta-D-glucohydrolase | Raucaffricine + H2O <=> Vomilenine + D-Glucose | Indole and ipecac alkaloid biosynthesis | 3.2.1.125
0.005 | 0.002 | 0.008 | R00801 | alpha-D-Glucoside glucohydrolase | Sucrose + H2O <=> D-Fructose + D-Glucose | Galactose metabolism | 3.2.1.20
0.005 | 0.001 | 0.009 | R02089 | ATP:deoxyadenosine 5\'-phosphotransferase | ATP + Deoxyadenosine <=> ADP + dAMP | Purine metabolism | 2.7.1.76
0.005 | 0.001 | 0.009 | R01357 | Acetoacetate:CoA ligase (AMP-forming) | ATP + Acetoacetate + CoA <=> AMP + Pyrophosphate + Acetoacetyl-CoA | Butanoate metabolism | 6.2.1.16
0.005 | 0.001 | 0.009 | R00868 | D-Mannitol:NAD+ 2-oxidoreductase | [NAME] + NAD+ <=> D-Fructose + NADH + H+ | Fructose and mannose metabolism | 1.1.1.11        1.1.1.67
0.005 | 0 | 0.01 | R02458 | D-Arginine amidinohydrolase | D-Arginine + H2O <=> D-Ornithine + Urea | D-Arginine and D-ornithine metabolism | 3.5.3.10
0.005 | 0 | 0.01 | R02323 | Nicotinamide ribonucleotide phosphohydrolase | Nicotinamide D-ribonucleotide + H2O <=> N-Ribosylnicotinamide + Orthophosphate | Nicotinate and nicotinamide metabolism | 3.1.3.5
0.0045 | 0.009 | 0 | R01450 |  | (S)-Lactate <=> (R)-Lactate | Pyruvate metabolism | 5.1.2.1
0.0045 | 0.009 | 0 | R00528 | Sulfite:ferricytochrome-c oxidoreductase | Sulfite + H2O + 2 Ferricytochrome c <=> Sulfate + 2 Ferrocytochrome c | Sulfur metabolism | 1.8.2.1
0.0045 | 0.009 | 0 | [NAME] | [NAME]:oxygen oxidoreductase | [NAME] <=> 2 3,4-Dihydroxy-L-phenylalanine | Tyrosine metabolism | 1.10.3.1
0.0045 | 0.009 | 0 | EC555 | Nucleoside triphosphate pyrophosphorylase (ctp) | [c]ctp + h2o --> cmp + h + ppi | Nucleotide Salvage Pathways
0.0045 | 0.006 | 0.003 | R00766 | UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase | UDP-glucose + D-Fructose 6-phosphate <=> UDP + Sucrose 6-phosphate | Starch and sucrose metabolism | 2.4.1.14
0.0045 | 0.006 | 0.003 | EC095 | trehalose-phosphatase | [c]h2o + tre6p --> pi + tre | Alternate Carbon Metabolism | EC-3.1.3.12
0.0045 | 0.006 | 0.003 | [NAME] | alpha,alpha-trehalose-phosphate synthase (UDP-forming) | [c]g6p + udpg --> h + tre6p + udp | Alternate Carbon Metabolism | EC-2.4.1.15
0.0045 | 0.005 | 0.004 | R07265 | alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase | alpha,alpha-Trehalose + Orthophosphate <=> alpha-D-Glucose + D-Glucose 1-phosphate |  | 2.4.1.231
0.0045 | 0.005 | 0.004 | R02032 | 6-Phospho-2-dehydro-D-gluconate:NAD+ 2-oxidoreductase | 6-Phospho-D-gluconate + NAD+ <=> 6-Phospho-2-dehydro-D-gluconate + NADH + H+ | Pentose phosphate pathway | 1.1.1.43
0.0045 | 0.004 | 0.005 | R01498 | D-Glucosyl-N-acylsphingosine glucohydrolase | Glucosylceramide + H2O <=> D-Glucose + N-Acylsphingosine | Sphingolipid metabolism | 3.2.1.45
0.0045 | 0.004 | 0.005 | R01497 | UDPglucose:N-acylsphingosine D-glucosyltransferase | UDP-glucose + N-Acylsphingosine <=> UDP + Glucosylceramide | Sphingolipid metabolism | 2.4.1.80
0.0045 | 0.004 | 0.005 | R00870 | D-Mannitol:NADP+ 2-oxidoreductase | [NAME] <=> D-Fructose + NADPH + H+ | Fructose and mannose metabolism | 1.1.1.138
0.0045 | 0.003 | 0.006 | R06620 | D-glucose:ubiquinone oxidoreductase | D-Glucose + Ubiquinone <=> D-Glucono-1,5-lactone + Ubiquinol | Pentose phosphate pathway | 1.1.5.2
0.0045 | 0.003 | 0.006 | R00802 | alpha-D-Glucoside glucohydrolase | Sucrose + H2O <=> beta-D-Fructose + alpha-D-Glucose | Starch and sucrose metabolism | 3.2.1.20        3.2.1.26        3.2.1.48
0.0045 | 0.003 | 0.006 | R00637 | Primary alcohol:oxygen oxidereductase | Primary alcohol + Oxygen <=> [NAME] |  | 1.1.3.13
0.0045 | 0.002 | 0.007 | R01704 | [NAME]:NAD+ oxidoreductase | Hexadecanal + NAD+ + H2O <=> Hexadecanoic acid + NADH + H+ | Fatty acid metabolism | 1.2.1.48
0.0045 | 0.002 | 0.007 | R01280 | Palmitate:CoA ligase (AMP-forming) | ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Pyrophosphate | Fatty acid metabolism | 6.2.1.3
0.0045 | 0.002 | 0.007 | R00319 | (S)-Lactate:oxygen 2-oxidoreductase(decarboxylating) | (S)-Lactate + Oxygen <=> Acetate + CO2 + H2O | Pyruvate metabolism | 1.13.12.4
0.0045 | 0.001 | 0.008 | R02630 | Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase | Protein N(pi)-phospho-L-histidine + D-Mannose <=> Protein histidine + D-Mannose 6-phosphate | Fructose and mannose metabolism | 2.7.1.69
0.0045 | 0.001 | 0.008 | R02595 | Coniferin beta-D-glucosidase | Coniferin + H2O <=> Coniferyl alcohol + D-Glucose | Stilbene, coumarine and lignin biosynthesis | 3.2.1.126
0.0045 | 0.001 | 0.008 | R02594 | UDPglucose:coniferyl-alcohol 4\'-beta-D-glucosyltransferase | UDP-glucose + Coniferyl alcohol <=> UDP + Coniferin | Stilbene, coumarine and lignin biosynthesis | 2.4.1.111
0.0045 | 0 | 0.009 | R05280 |  | 3,4-Dihydroxybenzoate + NH3 <=> 4-Aminobenzoate + Oxygen + 2 H+ | 2,4-Dichlorobenzoate degradation | 1.14.12.-
0.0045 | 0 | 0.009 | R04006 | 4-Hydroxycinnamyl alcohol 4-D-glucoside beta-D-glucosidase | 4-Hydroxycinnamyl alcohol 4-D-glucoside + H2O <=> 4-Coumaryl alcohol + D-Glucose | Stilbene, coumarine and lignin biosynthesis | 3.2.1.126
0.0045 | 0 | 0.009 | R04005 | UDPglucose:coniferyl-alcohol 4\'-beta-D-glucosyltransferase | UDP-glucose + 4-Coumaryl alcohol <=> UDP + 4-Hydroxycinnamyl alcohol 4-D-glucoside | Stilbene, coumarine and lignin biosynthesis | 2.4.1.111
0.0045 | 0 | 0.009 | R03605 | UDPglucose:coniferyl-alcohol 4\'-beta-D-glucosyltransferase | UDP-glucose + Sinapyl alcohol <=> UDP + Syringin | Stilbene, coumarine and lignin biosynthesis | 2.4.1.111
0.0045 | 0 | 0.009 | R03604 | Syringin beta-D-glucosidase | Syringin + H2O <=> Sinapyl alcohol + D-Glucose | Stilbene, coumarine and lignin biosynthesis | 3.2.1.126
0.0045 | 0 | 0.009 | R00822 | Protocatechuate carboxy-lyase | 3,4-Dihydroxybenzoate <=> Catechol + CO2 | Benzoate degradation via hydroxylation | 4.1.1.63
0.004 | 0.008 | 0 | R04859 | [NAME] acetate-lyase (adding hydrogen sulfide) | O-Acetyl-L-serine + Thiosulfate + Thioredoxin + H+ <=> L-Cysteine + Sulfite + Oxidized thioredoxin + Acetate | Cysteine metabolism | 2.5.1.47        2.5.1.49
0.004 | 0.008 | 0 | R03050 | 2-Acetolactate pyruvate-lyase (carboxylating) | 2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate | Butanoate metabolism | 2.2.1.6
0.004 | 0.008 | 0 | R00486 | 3-Cyano-L-alanine aminohydrolase | 3-Cyano-L-alanine + 2 H2O <=> L-Aspartate + NH3 | Cyanoamino acid metabolism | 3.5.5.4
0.004 | 0.007 | 0.001 | R03139 | 1,3-Diaminopropane:oxygen oxidoreductase (deaminating) (copper-containing) | 1,3-Diaminopropane + Oxygen + H2O <=> beta-Aminopropion aldehyde + NH3 + H2O2 | beta-Alanine metabolism | 1.4.3.6
0.004 | 0.007 | 0.001 | R00904 | beta-Aminopropion aldehyde:NAD+ oxidoreductase | beta-Aminopropion aldehyde + NAD+ + H2O <=> beta-Alanine + NADH | beta-Alanine metabolism | 1.2.1.3
0.004 | 0.006 | 0.002 | [NAME] | S-adenosyl-L-methionine:sarcosine N-methyltransferase | S-Adenosyl-L-methionine + Sarcosine <=> S-Adenosyl-L-homocysteine + N,N-Dimethylglycine |  | 2.1.1.156       2.1.1.157
0.004 | 0.006 | 0.002 | R05623 |  | Trimethylamine + NADH + H+ + Oxygen <=> Trimethylamine N-oxide + NAD+ + H2O | Methane metabolism | 1.14.13.-
0.004 | 0.006 | 0.002 | R00508 | 3\'-Phospho-5\'-adenylyl sulfate 3\'(2\')-phosphohydrolase | 3\'-Phosphoadenylyl sulfate + H2O <=> Adenylylsulfate + Orthophosphate | Sulfur metabolism | 3.1.3.7
0.004 | 0.006 | 0.002 | EC465 | tartronate semialdehyde reductase | [c]2h3oppan + h + nadh --> glyc-R + nad | Glyoxylate Metabolism | EC-1.1.1.60
0.004 | 0.005 | 0.003 | R07182 | hydrogen:(acceptor) oxidoreductase | Hydrogen + Acceptor <=> Reduced acceptor |  | 1.12.99.6
0.004 | 0.004 | 0.004 | R03293 | trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase | trans-4-Hydroxy-L-proline + NADP+ <=> L-1-Pyrroline-3-hydroxy-5-carboxylate + NADPH + H+ | Arginine and proline metabolism | 1.5.1.2
0.004 | 0.004 | 0.004 | R02569 | Acetyl-CoA:dihydrolipoamide S-acetyltransferase | Acetyl-CoA + Dihydrolipoamide <=> CoA + S-Acetyldihydrolipoamide | Glycolysis / Gluconeogenesis | 2.3.1.12
0.004 | 0.003 | 0.005 | R06985 | trans-Hex-2-enoyl-CoA reductase | trans-Hex-2-enoyl-CoA + NADPH + H+ <=> Hexanoyl-CoA + NADP+ | Fatty acid elongation in mitochondria | 1.3.1.38
0.004 | 0.003 | 0.005 | R04751 | Hexanoyl-CoA:(acceptor) 2,3-oxidoreductase | Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2 | Fatty acid metabolism | 1.3.3.6         1.3.99.2        1.3.99.3        1.3.99.13 1.3.99.-
0.004 | 0.003 | 0.005 | R01747 | (R)-Glycerate:NADP+ oxidoreductase | D-Glycerate + NADP+ <=> 2-Hydroxy-3-oxopropanoate + NADPH + H+ | Glyoxylate and dicarboxylate metabolism | 1.1.1.60
0.004 | 0.002 | 0.006 | [NAME] | NADH:ubiquinone oxidoreductase | Ubiquinol + NAD+ <=> Ubiquinone + NADH + H+ |  | 1.6.5.3
0.004 | 0.002 | 0.006 | R01962 |  | D-Glucosamine + Oxygen + H2O <=> 2-Amino-2-deoxy-D-gluconate + H2O2 | Aminosugars metabolism
0.004 | 0.002 | 0.006 | R01544 | 2-amino-2-deoxy-D-gluconate ammonia-lyase; D-Glucosaminate ammonia-lyase (isomerizing) | 2-Amino-2-deoxy-D-gluconate <=> 2-Dehydro-3-deoxy-D-gluconate + NH3 | Pentose phosphate pathway | 4.3.1.9
0.004 | 0.002 | 0.006 | R01041 | Glycerol:NADP+ oxidoreductase | Glycerol + NADP+ <=> D-Glyceraldehyde + NADPH + H+ | Glycerolipid metabolism | 1.1.1.1         1.1.1.2         1.1.1.21        1.1.1.72
0.004 | 0.002 | 0.006 | R00145 |  | alpha-Amino acid + H2O + NAD+ <=> 2-Oxo acid + NH3 + NADH + H+ | Nitrogen metabolism | 1.4.1.1         1.4.1.2         1.4.1.3         1.4.1.4 1.4.1.5         1.4.1.7         1.4.1.8         1.4.1.9 1.4.1.10        1.4.1.12        1.4.1.15        1.4.1.19 1.4.1.20
0.004 | 0.001 | 0.007 | R01273 | N-Ribosylnicotinamide ribohydrolase | N-Ribosylnicotinamide + H2O <=> Nicotinamide + D-Ribose | Nicotinate and nicotinamide metabolism | 3.2.2.1
0.004 | 0 | 0.008 | R00102 | NAD+ glycohydrolase | NAD+ + H2O <=> Nicotinamide + ADP-ribose | Nicotinate and nicotinamide metabolism | 3.2.2.5         3.2.2.6
0.0035 | 0.007 | 0 | R04269 |  | L-threo-3-Methylaspartate + 2-Oxoglutarate <=> Methyloxaloacetate + L-Glutamate | C5-Branched dibasic acid metabolism
0.0035 | 0.007 | 0 | R02260 | (S)-Lactaldehyde:NADP+ oxidoreductase | (S)-Lactaldehyde + NADP+ <=> Methylglyoxal + NADPH + H+ | Pyruvate metabolism | 1.2.1.49
0.0035 | 0.007 | 0 | R00995 |  | 2-Oxobutanoate + CO2 <=> Methyloxaloacetate | C5-Branched dibasic acid metabolism
0.0035 | 0.007 | 0 | R00525 | N-Formyl-L-glutamate amidohydrolase | N-Formyl-L-glutamate + H2O <=> Formate + L-Glutamate | Histidine metabolism,Glyoxylate and dicarboxylate metabolism | 3.5.1.68
0.0035 | 0.007 | 0 | R00262 | L-threo-3-Methylaspartate carboxy-aminomethylmutase | L-threo-3-Methylaspartate <=> L-Glutamate | C5-Branched dibasic acid metabolism | 5.4.99.1
0.0035 | 0.007 | 0 | EC561 | Nucleoside triphosphate pyrophosphorylase (gtp) | [c]gtp + h2o --> gmp + h + ppi | Nucleotide Salvage Pathways
0.0035 | 0.007 | 0 | EC282 | Malate dehydrogenase (menaquinone 8 as acceptor) | [c]mal-L + mqn8 --> mql8 + oaa | Citrate Cycle (TCA) | EC-1.1.99.16
0.0035 | 0.007 | 0 | EC273 | Citrate lyase | [c]cit --> ac + oaa | Citrate Cycle (TCA) | EC-4.1.3.6
0.0035 | 0.006 | 0.001 | EC024 | acetyl-CoA:acetoacetyl-CoA transferase | [c]acac + accoa --> aacoa + ac | Alternate Carbon Metabolism
0.0035 | 0.004 | 0.003 | R07409 | choline,reduced-ferredoxin:oxygen oxidoreductase | [NAME] ferredoxin + 2 H+ <=> [NAME] aldehyde + 2 H2O + 2 Oxidized ferredoxin | Glycine, serine and threonine metabolism | 1.14.15.7
0.0035 | 0.004 | 0.003 | R07154 | pyridoxine:(acceptor) 5-oxidoreductase | Pyridoxine + Acceptor <=> [NAME] acceptor |  | 1.1.99.9
0.0035 | 0.004 | 0.003 | R02560 | NADH:trimethylamine-N-oxide oxidoreductase | Trimethylamine + FAD + H2O <=> FADH2 + Trimethylamine N-oxide | Methane metabolism | 1.6.6.9
0.0035 | 0.004 | 0.003 | R01910 | Primary alcohol:(acceptor) oxidoreductase | Pyridoxine + Oxygen <=> Isopyridoxal + H2O2 | [NAME] metabolism | 1.1.99.9
0.0035 | 0.004 | 0.003 | R01346 | L-Asparagine:2-oxo-acid aminotransferase | L-Asparagine + 2-Oxo acid <=> 2-Oxosuccinamate + L-Amino acid | Alanine and aspartate metabolism,Tetracycline biosynthesis | 2.6.1.14
0.0035 | 0.004 | 0.003 | R00608 | Methanol:oxygen oxidereductase | Methanol + Oxygen <=> Formaldehyde + H2O2 | Methane metabolism | 1.1.3.13
0.0035 | 0.004 | 0.003 | R00348 | 2-Oxosuccinamate amidohydrolase | 2-Oxosuccinamate + H2O <=> Oxaloacetate + NH3 | Alanine and aspartate metabolism | 3.5.1.3
0.0035 | 0.004 | 0.003 | EC583 | uridine kinase (GTP:Uridine) | [c]gtp + uri --> gdp + h + ump | Nucleotide Salvage Pathways | EC-2.7.1.48
0.0035 | 0.004 | 0.003 | EC544 | Nucleoside triphosphate tripolyhydrolase | [c]dgtp + h2o --> dgsn + pppi | Nucleotide Salvage Pathways | EC-3.1.5.1
0.0035 | 0.002 | 0.005 | R01054 | ADPribose ribophosphohydrolase | ADP-ribose + H2O <=> AMP + D-Ribose 5-phosphate | Purine metabolism | 3.6.1.13
0.0035 | 0.002 | 0.005 | R00975 | 5,6-Dihydrouracil:oxygen oxidoreductase | 5,6-Dihydrouracil + Oxygen <=> Uracil + H2O2 |  | 1.3.3.7
0.0035 | 0.001 | 0.006 | R02319 | NTP phosphohydrolase | Nucleoside triphosphate + H2O <=> NDP + Orthophosphate |  | 3.6.1.15
0.0035 | 0.001 | 0.006 | R01685 | Taurine:ferricytochrome-c oxidoreductase (deaminating) | Taurine + H2O + 2 Ferricytochrome c <=> Sulfoacetaldehyde + NH3 + 2 Ferrocytochrome c | Taurine and hypotaurine metabolism,Nitrogen metabolism | 1.4.2.-
0.0035 | 0.001 | 0.006 | R00453 | L-Lysine:pyruvate aminotransferase | L-Lysine + Pyruvate <=> L-2-Aminoadipate 6-semialdehyde + L-Alanine |  | 2.6.1.71
0.003 | 0.006 | 0 | R07139 | lactaldehyde:NADP+ oxidoreductase | [NAME] <=> Methylglyoxal + NADPH + H+ |  | 1.1.1.283
0.003 | 0.006 | 0 | R03601 | [NAME] acetate-lyase (adding hydrogen sulfide) | O-Acetyl-L-serine + Selenide <=> Selenocysteine + Acetate | Selenoamino acid metabolism | 2.5.1.47
0.003 | 0.006 | 0 | R03599 | Selenocysteine reductase | Selenocysteine + Reduced acceptor <=> Selenide + L-Alanine + Acceptor | Selenoamino acid metabolism | 4.4.1.16
0.003 | 0.006 | 0 | R02198 | L-Isoleucine:2-oxoglutarate aminotransferase | L-Isoleucine + 2-Oxoglutarate <=> 3-Methyl-2-oxopentanoate + L-Glutamate | [NAME], leucine and isoleucine degradation | 2.6.1.42
0.003 | 0.006 | 0 | R02197 | L-Isoleucine:oxygen oxidoreductase (deaminating) | L-Isoleucine + Oxygen + H2O <=> 3-Methyl-2-oxopentanoate + NH3 + H2O2 | [NAME], leucine and isoleucine degradation | 1.4.3.2
0.003 | 0.006 | 0 | R02166 | NADH:ubiquinone oxidoreductase | Ubiquinol <=> Ubiquinone + 2 H+ | Ubiquinone biosynthesis | 1.6.5.3
0.003 | 0.006 | 0 | R01342 | D-Amino-acid:(acceptor) oxidoreductase (deaminating) | alpha-Amino acid + H2O + Acceptor <=> 2-Oxo acid + NH3 + Reduced acceptor | Nitrogen metabolism | 1.4.99.1
0.003 | 0.006 | 0 | EC624 | glycerol-3-phosphate dehydrogenase (menaquinone-8) | [c]glyc3p + mqn8 --> dhap + mql8 | Oxidative phosphorylation | EC-1.1.99.5
0.003 | 0.006 | 0 | EC481 | acetyl-CoA C-acetyltransferase | [c](2) accoa <==> aacoa + coa | Membrane Lipid Metabolism | EC-2.3.1.9
0.003 | 0.006 | 0 | [NAME] | malic enzyme (NADP) | [c]mal-L + nadp --> co2 + nadph + pyr | Anaplerotic reactions | EC-1.1.1.40
0.003 | 0.005 | 0.001 | R05112 | [NAME] galactohydrolase | GA1 + H2O <=> GA2 + D-Galactose |  | 3.2.1.23
0.003 | 0.005 | 0.001 | R05111 |  | UDP-D-galactose + GA2 <=> UDP + GA1 |  | 2.4.1.62
0.003 | 0.005 | 0.001 | R01151 | Putrescine:oxygen oxidoreductase (deaminating) | [NAME] H2O <=> 4-Aminobutanal + NH3 + H2O2 | Arginine and proline metabolism | 1.4.3.6         1.4.3.10
0.003 | 0.005 | 0.001 | R00500 |  | 2 Glutathione <=> Oxidized glutathione | Glutamate metabolism | 1.8.4.-
0.003 | 0.004 | 0.002 | [NAME] | Glutathione:protein-disulfide oxidoreductase | Protein dithiol + Oxidized glutathione <=> Protein disulfide + 2 Glutathione | Glutathione metabolism | 1.8.4.2
0.003 | 0.004 | 0.002 | R01959 | N-Formyl-L-kynurenine amidohydrolase | L-Formylkynurenine + H2O <=> Formate + L-Kynurenine | Tryptophan metabolism,Glyoxylate and dicarboxylate metabolism | 3.5.1.9
0.003 | 0.004 | 0.002 | R00987 | L-Kynurenine hydrolase | L-Kynurenine + H2O <=> Anthranilate + L-Alanine | Tryptophan metabolism | 3.7.1.3
0.003 | 0.004 | 0.002 | [NAME] | Ammonia:(acceptor) oxidoreductase | Acceptor + NH3 + H2O <=> Hydroxylamine + Reduced acceptor |  | 1.7.99.1
0.003 | 0.003 | 0.003 | R02631 | Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase | Protein N(pi)-phospho-L-histidine + D-Glucosamine <=> Protein histidine + D-Glucosamine 6-phosphate | Aminosugars metabolism | 2.7.1.69
0.003 | 0.003 | 0.003 | R01565 | N,N-Dimethylglycine:(acceptor) oxidoreductase (demethylating) | N,N-Dimethylglycine + Acceptor + H2O <=> Sarcosine + Formaldehyde + Reduced acceptor | Glycine, serine and threonine metabolism | 1.5.99.2
0.003 | 0.002 | 0.004 | R04968 | Tetradecanoyl-[acyl-carrier protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) | Tetradecanoyl-[acp] + Malonyl-[acyl-carrier protein] <=> 3-Oxohexadecanoyl-[acp] + CO2 + Acyl-carrier protein | Fatty acid biosynthesis | 2.3.1.41        2.3.1.85        2.3.1.86
0.003 | 0.002 | 0.004 | R04544 | (3R)-3-Hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase | (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] <=> trans-Hexadec-2-enoyl-[acp] + H2O | Fatty acid biosynthesis | 2.3.1.85        2.3.1.86        4.2.1.61
0.003 | 0.002 | 0.004 | R04543 | (3R)-3-Hydroxypalmitoyl-[acyl-carrier-protein]:NADP+ oxidoreductase | (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxohexadecanoyl-[acp] + NADPH | Fatty acid biosynthesis | 1.1.1.100       2.3.1.85        2.3.1.86
0.003 | 0.002 | 0.004 | R02459 | D-Ornithine:2-oxoglutarate aminotransferase | D-Ornithine + 2-Oxo acid <=> 5-Amino-2-oxopentanoic acid + D-Amino acid | D-Arginine and D-ornithine metabolism | 2.6.1.21
0.003 | 0.002 | 0.004 | R01699 | Pyruvate:lipoamide 2-oxidoreductase(decarboxylating and acceptor-acetylating) | Pyruvate + Lipoamide <=> S-Acetyldihydrolipoamide + CO2 |  | 1.2.4.1
0.003 | 0.002 | 0.004 | R01449 | Acetyl-CoA:propanoate CoA-transferase | Lactoyl-CoA + Propanoate <=> (S)-Lactate + Propanoyl-CoA | Propanoate metabolism | 2.8.3.1
0.003 | 0.002 | 0.004 | [NAME] | ADP:sulfate adenylyltransferase | ADP + Sulfate <=> Orthophosphate + Adenylylsulfate | Sulfur metabolism | 2.7.7.5
0.003 | 0.001 | 0.005 | R07160 | 3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating;CoA-2-methylpropanoylating) | 3-Methyl-2-oxobutanoic acid + CoA + Oxidized ferredoxin <=> 2-Methylpropanoyl-CoA + CO2 + Reduced ferredoxin |  | 1.2.7.7
0.003 | 0.001 | 0.005 | R05199 | Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase | Protein N(pi)-phospho-L-histidine + N-Acetyl-D-glucosamine <=> Protein histidine + N-Acetyl-D-glucosamine 6-phosphate | Aminosugars metabolism | 2.7.1.69
0.003 | 0.001 | 0.005 | R01210 | 3-Methyl-2-oxobutanoate:NAD+ oxidoreductase (CoA-mehtylpropanoylating) | 3-Methyl-2-oxobutanoic acid + CoA + NAD+ <=> 2-Methylpropanoyl-CoA + CO2 + NADH | [NAME], leucine and isoleucine degradation | 1.2.1.25
0.003 | 0.001 | 0.005 | R00333 | nucleoside-triphosphate:AMP phosphotransferase | Nucleoside triphosphate + AMP <=> NDP + ADP |  | 2.7.4.10
0.003 | 0 | 0.006 | R05048 | GTP 7,8-8,9-dihydrolase | 2,5-Diaminopyrimidine nucleoside triphosphate <=> 2,5-Diamino-6-(5\'-triphosphoryl-3\',4\'-trihydroxy-2\'-oxopentyl)- amino-4-oxopyrimidine | Folate biosynthesis | 3.5.4.16        6.-.-.-
0.003 | 0 | 0.006 | R05046 | Formamidopyrimidine nucleoside triphosphate 7,8-8,9-dihydrolase | Formamidopyrimidine nucleoside triphosphate + H2O <=> 2,5-Diaminopyrimidine nucleoside triphosphate + Formate | Folate biosynthesis | 3.5.4.16
0.003 | 0 | 0.006 | R04639 | 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate 7,8-8,9-dihydrolase | 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate + H2O <=> 2,5-Diamino-6-(5\'-triphosphoryl-3\',4\'-trihydroxy-2\'-oxopentyl)- amino-4-oxopyrimidine | Folate biosynthesis | 3.5.4.16
0.003 | 0 | 0.006 | R00815 | phenol,NADPH:oxogen oxidoreductase (2-hydroxylating) | [NAME] H+ <=> Catechol + NADP+ + H2O | Nitrobenzene degradation | 1.14.13.7
0.003 | 0 | 0.006 | R00697 | L-Phenylalanine ammonia-lyase | L-Phenylalanine <=> trans-Cinnamate + NH3 | Phenylalanine metabolism,Nitrogen metabolism,Alkaloid biosynthesis II | 4.3.1.5
0.003 | 0 | 0.006 | [NAME] | L-Lysine:2-oxoglutarate 6-aminotransferase | L-Lysine + 2-Oxoglutarate <=> L-2-Aminoadipate 6-semialdehyde + L-Glutamate | Lysine biosynthesis | 2.6.1.36
0.003 | 0 | 0.006 | R00428 | GTP 7,8-8,9-dihydrolase | GTP + H2O <=> Formamidopyrimidine nucleoside triphosphate | Folate biosynthesis | 3.5.4.16
0.003 | 0 | 0.006 | R00287 | UDPglucose pyrophosphohydrolase | UDP-glucose + H2O <=> UMP + D-Glucose 1-phosphate | Pyrimidine metabolism,Starch and sucrose metabolism | 3.6.1.8         3.6.1.9
0.003 | 0 | 0.006 | EC584 | [NAME] (GTP) | [c]cytd + gtp --> cmp + gdp + h | Nucleotide Salvage Pathways
0.003 | 0 | 0.006 | EC438 | glutaminase | [c]gln-L + h2o --> glu-L + nh4 | Glutamate metabolism | EC-3.5.1.2
0.0025 | 0.005 | 0 | R07286 | 3-mercaptopyruvate:cyanide sulfurtransferase | Mercaptopyruvate + Cyanide <=> Pyruvate + Thiocyanate |  | 2.8.1.2
0.0025 | 0.005 | 0 | R01048 | Glycerol hydro-lyase | Glycerol <=> Lactaldehyde + H2O | Glycerolipid metabolism | 4.2.1.30
0.0025 | 0.005 | 0 | R00895 | L-Cysteine:2-oxoglutarate aminotransferase | L-Cysteine + 2-Oxoglutarate <=> Mercaptopyruvate + L-Glutamate | Cysteine metabolism | 2.6.1.3
0.0025 | 0.005 | 0 | R00790 | Ammonia:ferredoxin oxidoreductase | NH3 + 2 H2O + 6 Oxidized ferredoxin <=> Nitrite + 6 Reduced ferredoxin + 7 H+ | Nitrogen metabolism | 1.7.7.1
0.0025 | 0.005 | 0 | [NAME] | Cyanide sulfurtransferase | [c]cyan + tsul --> h + so3 + tcynt | Unassigned | [NAME]
0.0025 | 0.005 | 0 | EC707 | D-lactate dehydrogenase | [c]lac-D + nad <==> h + nadh + pyr | Pyruvate metabolism | EC-1.1.1.28
0.0025 | 0.005 | 0 | EC468 | Glycolate dehydrogenase (NADP) | [c]glx + h + nadph --> glyclt + nadp | Glyoxylate Metabolism
0.0025 | 0.005 | 0 | EC456 | glycogen phosphorylase | [c]glycogen + pi --> g1p | Glycolysis/Gluconeogenesis | [NAME]
0.0025 | 0.005 | 0 | EC049 | Glycolate oxidase | [c]glyclt + mqn8 --> glx + mql8 | Alternate Carbon Metabolism
0.0025 | 0.004 | 0.001 | R03441 | Kynurenate,acceptor:oxygen oxidoreductase (hydroxylating) | 4-Hydroxy-2-quinolinecarboxylic acid + Reduced acceptor + Oxygen <=> 7,8-Dihydro-7,8-dihydroxykynurenate + Acceptor |  | 1.14.99.2
0.0025 | 0.004 | 0.001 | R01914 | Spermidine:(acceptor) oxidoreductase | [NAME] H2O <=> 1,3-Diaminopropane + 4-Aminobutanal + H2O2 | beta-Alanine metabolism | 1.5.99.6
0.0025 | 0.004 | 0.001 | R00921 | acetyl-CoA:phosphate acetyltransferase | Propanoyl-CoA + Orthophosphate <=> Propanoyl phosphate + CoA | Propanoate metabolism | 2.3.1.8
0.0025 | 0.004 | 0.001 | [NAME] | (3S)-citramalate pyruvate-lyase | (S)-2-Methylmalate <=> Acetate + Pyruvate | C5-Branched dibasic acid metabolism | 4.1.3.22
0.0025 | 0.004 | 0.001 | R00237 | (3S)-Citramalyl-CoA pyruvate-lyase | (3S)-Citramalyl-CoA <=> Acetyl-CoA + Pyruvate | Pyruvate metabolism,C5-Branched dibasic acid metabolism | 4.1.3.22        4.1.3.25
0.0025 | 0.004 | 0.001 | EC126 | [NAME] | [c]fru --> glc-D | Alternate Carbon Metabolism | [NAME]
0.0025 | 0.004 | 0.001 | EC113 | Propionate kinase | [c]adp + ppap <==> atp + ppa | Alternate Carbon Metabolism
0.0025 | 0.003 | 0.002 | R05318 | Ferrocytochrome-c:Fe3+ oxidoreductase | Ferrocytochrome c + Fe3+ <=> Ferricytochrome c + Fe2+ |  | 1.9.99.1
0.0025 | 0.003 | 0.002 | R02057 | CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase | CDP-ethanolamine + 1,2-Diacyl-sn-glycerol <=> CMP + Phosphatidylethanolamine | Glycerophospholipid metabolism | 2.7.8.1
0.0025 | 0.003 | 0.002 | R02052 | Phosphatidylethanolamine cholinephosphohydrolase | Phosphatidylethanolamine + H2O <=> 1,2-Diacyl-sn-glycerol + Ethanolamine phosphate | Glycine, serine and threonine metabolism,Glycerophospholipid metabolism | 3.1.4.3
0.0025 | 0.003 | 0.002 | R01112 | Glutathione:dehydroascorbate oxidoreductase | Dehydroascorbate + 2 Glutathione <=> Oxidized glutathione + Ascorbate | Glutamate metabolism,Glutathione metabolism | 1.8.5.1
0.0025 | 0.002 | 0.003 | R03857 | Lauroyl-CoA:(acceptor) 2,3-oxidoreductase | Lauroyl-CoA + FAD <=> 2-trans-Dodecenoyl-CoA + FADH2 | Fatty acid metabolism | 1.3.3.6         1.3.99.3        1.3.99.13       1.3.99.-
0.0025 | 0.002 | 0.003 | R03856 | [NAME] reductase | Lauroyl-CoA + NADP+ <=> 2-trans-Dodecenoyl-CoA + NADPH + H+ | Fatty acid elongation in mitochondria | 1.3.1.38
0.0025 | 0.002 | 0.003 | R02728 | beta-D-Glucose 1-phosphate 1,6-phosphomutase | beta-D-Glucose 1-phosphate <=> beta-D-Glucose 6-phosphate | Starch and sucrose metabolism | 5.4.2.6
0.0025 | 0.002 | 0.003 | R01817 | D-mannitol-1-phosphate:NADP+ 6-oxidoreductase | D-Mannitol 1-phosphate + NADP+ <=> D-Mannose 6-phosphate + NADPH + H+ |  | 1.1.1.224
0.0025 | 0.002 | 0.003 | R00977 | 5,6-Dihydrouracil:NAD+ oxidoreductase | 5,6-Dihydrouracil + NAD+ <=> Uracil + NADH + H+ | Pyrimidine metabolism,beta-Alanine metabolism,Pantothenate and CoA biosynthesis | 1.3.1.1
0.0025 | 0.002 | 0.003 | R00783 | Ferrocytochrome-c:oxygen oxidoreductase | Nitric oxide + H2O + Ferricytochrome c <=> Nitrite + Ferrocytochrome c + 2 H+ | Nitrogen metabolism | 1.7.2.1
0.0025 | 0.002 | 0.003 | R00631 | [NAME]:NAD+ oxidoreductase | [NAME] + NAD+ + H2O <=> Fatty acid + NADH | Fatty acid metabolism | 1.2.1.3
0.0025 | 0.001 | 0.004 | R00538 | [NAME]:NAD+ oxidoreductase | [NAME] + NAD+ + H2O <=> Carboxylate + NADH |  | 1.2.1.3
0.0025 | 0 | 0.005 | R05735 | acetone:carbon-dioxide ligase (AMP-forming) | Acetone + CO2 + ATP + 2 H2O <=> Acetoacetate + AMP + 2 Orthophosphate |  | 6.4.1.6
0.0025 | 0 | 0.005 | R02321 | NTP:deoxycitidine 5\'-phosphotransferase | Nucleoside triphosphate + Deoxycytidine <=> NDP + dCMP |  | 2.7.1.74
0.0025 | 0 | 0.005 | [NAME] | Acetoacetate carboxy-lyase | Acetoacetate <=> Acetone + CO2 | Synthesis and degradation of ketone bodies,Propanoate metabolism | 4.1.1.4
0.0025 | 0 | 0.005 | R01018 | CTP:dolichol O-phosphotransferase | CTP + Dolichol <=> CDP + Dolichyl phosphate | N-Glycan biosynthesis | 2.7.1.108
0.0025 | 0 | 0.005 | R01003 | Dolichyl-phosphate phosphohydrolase | Dolichyl phosphate + H2O <=> Dolichol + Orthophosphate | N-Glycan biosynthesis | 3.1.3.51
0.0025 | 0 | 0.005 | R00026 | beta-D-Glucoside glucohydrolase | Cellobiose + H2O <=> 2 beta-D-Glucose | Starch and sucrose metabolism | 3.2.1.21
0.002 | 0.004 | 0 | R04293 |  | Pyridine-2,3-dicarboxylate + H2O <=> 2-Amino-3-carboxymuconate semialdehyde | Tryptophan metabolism
0.002 | 0.004 | 0 | R03189 | 5-Formyltetrahydrofolate:L-glutamate N-formiminotransferase | 5-Formyltetrahydrofolate + L-Glutamate <=> Tetrahydrofolate + N-Formyl-L-glutamate | One carbon pool by folate | 2.1.2.5
0.002 | 0.004 | 0 | R02665 | 3-Hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing) | 3-Hydroxyanthranilate + Oxygen <=> 2-Amino-3-carboxymuconate semialdehyde | Tryptophan metabolism | 1.13.11.6
0.002 | 0.004 | 0 | R02527 | (R)-Lactaldehyde:NAD+ oxidoreductase | (R)-Lactaldehyde + NAD+ <=> Methylglyoxal + NADH + H+ | Pyruvate metabolism | 1.1.1.78        1.1.1.79
0.002 | 0.004 | 0 | R01816 | Anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) | Tetrahydrobiopterin + Anthranilate + Oxygen <=> 3-Hydroxyanthranilate + Dihydrobiopterin + H2O | Tryptophan metabolism | 1.14.16.3
0.002 | 0.004 | 0 | R01735 | (R)-Lactaldehyde:NAD+ 2-oxidoreductase | (R)-Lactaldehyde + NAD+ + H2O <=> (R)-Lactate + NADH | Pyruvate metabolism | 1.2.1.23
0.002 | 0.004 | 0 | EC594 | 5'-nucleotidase (GMP) | [c]gmp + h2o --> gsn + pi | Nucleotide Salvage Pathways | EC-3.1.3.5
0.002 | 0.004 | 0 | EC558 | Nucleoside triphosphate pyrophosphorylase (dttp) | [c]dttp + h2o --> dtmp + h + ppi | Nucleotide Salvage Pathways
0.002 | 0.004 | 0 | EC482 | CDP-Diacylglycerol pyrophostatase (Ecoli) | [c](0.02) cdpdag1 + h2o --> cmp + (2) h + (0.02) pa_EC | Membrane Lipid Metabolism | EC-3.6.1.26
0.002 | 0.004 | 0 | EC137 | 2-dehydro-D-gluconate reductase (NADPH) | [c]2dhglcn + h + nadph --> glcn + nadp | Alternate Carbon Metabolism | EC-1.1.1.215
0.002 | 0.004 | 0 | EC043 | galactokinase | [c]atp + gal <==> adp + gal1p + h | Alternate Carbon Metabolism | EC-2.7.1.6
0.002 | 0.004 | 0 | EC019 | lactaldehyde dehydrogenase | [c]h2o + lald-L + nad <==> (2) h + lac-L + nadh | Alternate Carbon Metabolism | EC-1.2.1.22
0.002 | 0.004 | 0 | EC012 | beta-fructofuranosidase | [c]h2o + suc6p --> fru + g6p | Alternate Carbon Metabolism | EC-3.2.1.26
0.002 | 0.003 | 0.001 | R03914 | NADPH:protein-disulfide oxidoreductase | Protein dithiol + NADP+ <=> Protein disulfide + NADPH + H+ |  | 1.8.1.8
0.002 | 0.003 | 0.001 | R03793 |  | (S)-Mandelate + Acceptor <=> alpha-Oxo-benzeneacetic acid + Reduced acceptor |  | 1.1.99.-
0.002 | 0.003 | 0.001 | R03792 |  | (S)-Mandelate + NAD+ <=> alpha-Oxo-benzeneacetic acid + NADH |  | 1.1.1.-
0.002 | 0.003 | 0.001 | R02963 | Lactoyl-CoA hydro-lyase | Lactoyl-CoA <=> Propenoyl-CoA + H2O | Propanoate metabolism,[NAME] degradation | 4.2.1.54
0.002 | 0.003 | 0.001 | R02212 | Progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating) | Progesterone + Reduced acceptor + Oxygen <=> Testosterone acetate + Acceptor + H2O |  | 1.14.99.4
0.002 | 0.003 | 0.001 | R02210 | Ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing) | Progesterone + Oxygen + NADPH <=> Testosterone acetate + NADP+ + H2O |  | 1.14.13.54
0.002 | 0.003 | 0.001 | R01854 | RCH2NH2:(acceptor) oxidoreductase (deaminating) | RCH2NH2 + H2O + Acceptor <=> Aldehyde + NH3 + Reduced acceptor |  | 1.4.99.3        1.4.99.4
0.002 | 0.003 | 0.001 | R01853 | RCH2NH2:oxygen oxidoreductase(deaminating)(flavin-containing); RCH2NH2:oxygen oxidoreductase (deaminating) (copper-containing) | RCH2NH2 + H2O + Oxygen <=> Aldehyde + NH3 + H2O2 |  | 1.4.3.4         1.4.3.6
0.002 | 0.003 | 0.001 | EC060 | hydroxypyruvate isomerase | [c]hpyr <==> 2h3oppan | Alternate Carbon Metabolism | EC-5.3.1.22
0.002 | 0.002 | 0.002 | R04919 |  | 3-Hydroxypropionyl-CoA + NADP+ <=> 3-Oxopropionyl-CoA + NADPH | Propanoate metabolism
0.002 | 0.002 | 0.002 | R02269 | 5,6-Dihydrouracil amidohydrolase | 5,6-Dihydrouracil + H2O <=> 3-Ureidopropionate | Pyrimidine metabolism,beta-Alanine metabolism,Pantothenate and CoA biosynthesis | 3.5.2.2
0.002 | 0.002 | 0.002 | R01443 | Cellobiose:(acceptor) 1-oxidoreductase | Cellobiose + Acceptor <=> Cellobiono-1,5-lactone + Reduced acceptor |  | 1.1.99.18
0.002 | 0.002 | 0.002 | R01442 | Cellobiose:oxygen 1-oxidoreductase | [NAME] <=> Cellobiono-1,5-lactone + H2O2 |  | 1.1.99.18
0.002 | 0.002 | 0.002 | R00905 | N-Carbamoyl-beta-alanine amidohydrolase | 3-Ureidopropionate + H2O <=> beta-Alanine + CO2 + NH3 | Pyrimidine metabolism,beta-Alanine metabolism,Pantothenate and CoA biosynthesis | 3.5.1.6
0.002 | 0.002 | 0.002 | R00793 | Hydroxylamine:oxygen oxidoreductase | Nitrite + H2O <=> Hydroxylamine + Oxygen | Nitrogen metabolism | 1.7.3.4
0.002 | 0.002 | 0.002 | R00744 |  | Malonyl-CoA + H2O + NADP+ <=> 3-Oxopropionyl-CoA + Oxygen + NADPH | Propanoate metabolism
0.002 | 0.002 | 0.002 | R00677 | L-Tryptophan:oxygen oxidoreductase (deaminating) | L-Tryptophan + H2O + Oxygen <=> Indolepyruvate + NH3 + H2O2 | Tryptophan metabolism | 1.4.3.2
0.002 | 0.002 | 0.002 | R00638 |  | [NAME] + Acceptor + H2O <=> Fatty acid + Reduced acceptor | Fatty acid metabolism | 1.2.99.3
0.002 | 0.002 | 0.002 | R00035 | L-Ascorbate:oxygen oxidoreductase | Oxygen + 2 Ascorbate <=> 2 Dehydroascorbate + 2 H2O |  | 1.10.3.3
0.002 | 0.001 | 0.003 | R05508 |  | Lactoyl-CoA + Acetate <=> (S)-Lactate + Acetyl-CoA | Styrene degradation | 2.8.3.1
0.002 | 0.001 | 0.003 | R04970 | Hexadecanoyl-[acyl-carrier protein:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) | Hexadecanoyl-[acp] + NADP+ <=> trans-Hexadec-2-enoyl-[acp] + NADPH | Fatty acid biosynthesis | 1.3.1.10        2.3.1.85
0.002 | 0.001 | 0.003 | R03921 | Sucrose 6-phosphate fructohydrolase | Sucrose 6-phosphate + H2O <=> beta-D-Fructose + alpha-D-Glucose 6-phosphate | Starch and sucrose metabolism | 3.2.1.26
0.002 | 0.001 | 0.003 | R00805 | Sucrose-6-phosphate phosphohydrolase | Sucrose 6-phosphate + H2O <=> Sucrose + Orthophosphate | Starch and sucrose metabolism | 3.1.3.24
0.002 | 0.001 | 0.003 | [NAME] | [NAME]:oxygen oxidoreductase | [NAME] H2O <=> Carboxylate + H2O2 |  | 1.2.3.1
0.002 | 0.001 | 0.003 | R00625 | primary_alcohol:NADP+ oxidoreductase | Primary alcohol + NADP+ <=> [NAME] H+ |  | 1.1.1.2         1.1.1.71
0.002 | 0.001 | 0.003 | R00274 | Glutathione:hydrogen-peroxide oxidoreductase | H2O2 + 2 Glutathione <=> Oxidized glutathione + 2 H2O | Glutathione metabolism | 1.11.1.9
0.002 | 0 | 0.004 | R02704 | Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase | Protein N(pi)-phospho-L-histidine + [NAME] <=> Protein histidine + D-Mannitol 1-phosphate | Fructose and mannose metabolism | 2.7.1.69
0.002 | 0 | 0.004 | R00951 | ADPglucose sugarphosphohydrolase | ADP-glucose + H2O <=> AMP + D-Glucose 1-phosphate | Starch and sucrose metabolism | 3.6.1.21
0.002 | 0 | 0.004 | R00184 | P1,P4-Bis(5\'-adenosyl) tetraphosphate nucleotidohydrolase | P1,P4-Bis(5\'-adenosyl) tetraphosphate + H2O <=> ATP + AMP | Purine metabolism | 3.6.1.17
0.002 | 0 | 0.004 | R00126 | ADP:ATP adenylyltransferase | ADP + ATP <=> Orthophosphate + P1,P4-Bis(5\'-adenosyl) tetraphosphate | Purine metabolism | 2.7.7.53
0.002 | 0 | 0.004 | [NAME] | NMN nucleosidase | [c]h2o + nmn --> h + ncam + r5p | Cofactor and Prosthetic Group Biosynthesis | EC-3.2.2.14
0.0015 | 0.003 | 0 | R07213 | L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating) | L-Tryptophan + Tetrahydrobiopterin + Oxygen <=> 5-Hydroxy-L-tryptophan + 4a-Hydroxytetrahydrobiopterin |  | 1.14.16.4
0.0015 | 0.003 | 0 | R03972 |  | 3-Cyano-L-alanine <=> L-2,4-Diaminobutanoate | Cyanoamino acid metabolism
0.0015 | 0.003 | 0 | R03439 | kynurenate:oxygen oxidoreductase (hydroxylating) | 4-Hydroxy-2-quinolinecarboxylic acid + Oxygen + NADH + H+ <=> 7,8-Dihydro-7,8-dihydroxykynurenate + NAD+ | Tryptophan metabolism | 1.14.99.2
0.0015 | 0.003 | 0 | R02914 | 4,5-Dihydro-4-oxo-5-imidazolepropanoate hydro-lyase | 4-Imidazolone-5-propanoate <=> Urocanate + H2O | Histidine metabolism | 4.2.1.49
0.0015 | 0.003 | 0 | [NAME] | 4-imidazolone-5-propanoate amidohydrolase | 4-Imidazolone-5-propanoate + H2O <=> N-Formimino-L-glutamate + H+ | Histidine metabolism | 3.5.2.7
0.0015 | 0.003 | 0 | R02286 | N-Formimino-L-glutamate iminohydrolase | N-Formimino-L-glutamate + H2O <=> N-Formyl-L-glutamate + NH3 | Histidine metabolism | 3.5.3.13
0.0015 | 0.003 | 0 | R01814 | L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) | Tetrahydrobiopterin + L-Tryptophan + Oxygen <=> 5-Hydroxy-L-tryptophan + Dihydrobiopterin + H2O | Tryptophan metabolism | 1.14.16.4
0.0015 | 0.003 | 0 | R01365 | Butanoyl-CoA:acetoacetate CoA-transferase | Butanoyl-CoA + Acetoacetate <=> Butanoic acid + Acetoacetyl-CoA |  | 2.8.3.9
0.0015 | 0.003 | 0 | R01168 | L-Histidine ammonia-lyase | L-Histidine <=> Urocanate + NH3 | Histidine metabolism,Nitrogen metabolism | 4.3.1.3
0.0015 | 0.003 | 0 | R01098 | D-Galactose:oxygen 6-oxidoreductase | D-Galactose + Oxygen + H2O <=> D-Galactonate + H2O2 | Galactose metabolism | 1.1.3.9
0.0015 | 0.003 | 0 | R00941 | 10-formyltetrahydrofolate:NADP+ oxidoreductase | 10-Formyltetrahydrofolate + NADP+ + H2O <=> Tetrahydrofolate + CO2 + NADPH + H+ | One carbon pool by folate | 1.5.1.6
0.0015 | 0.003 | 0 | R00833 | (R)-2-Methyl-3-oxopropanoyl-CoA CoA-carbonylmutase | (R)-2-Methyl-3-oxopropanoyl-CoA <=> Succinyl-CoA | [NAME], leucine and isoleucine degradation,Propanoate metabolism | 5.4.99.2
0.0015 | 0.003 | 0 | R00136 | ATP:polyphosphate phosphotransferase | ATP + Pyrophosphate <=> ADP + Triphosphate |  | 2.7.4.1
0.0015 | 0.003 | 0 | EC914 | catalase | [c](2) h2o2 --> (2) h2o + o2 | Unassigned | EC-1.11.1.6
0.0015 | 0.003 | 0 | EC559 | Nucleoside triphosphate pyrophosphorylase (utp) | [c]h2o + utp --> h + ppi + ump | Nucleotide Salvage Pathways
0.0015 | 0.003 | 0 | EC469 | Glycolate dehydrogenase (NAD) | [c]glx + h + nadh --> glyclt + nad | Glyoxylate Metabolism
0.0015 | 0.003 | 0 | EC386 | pyridoxamine kinase | [c]atp + pydam --> adp + h + pyam5p | Cofactor and Prosthetic Group Biosynthesis | EC-2.7.1.35
0.0015 | 0.003 | 0 | EC293 | Pyridoxal 5-phosphate phosphatase | [c]h2o + pydx5p --> pi + pydx | Cofactor and Prosthetic Group Biosynthesis
0.0015 | 0.003 | 0 | EC153 | [NAME] dehydrogenase | [c]4abutn + h2o + nad --> 4abut + (2) h + nadh | Arginine and Proline Metabolism | EC-1.2.1.19
0.0015 | 0.003 | 0 | EC148 | malic enzyme (NAD) | [c]mal-L + nad --> co2 + nadh + pyr | Anaplerotic reactions | EC-1.1.1.38
0.0015 | 0.003 | 0 | EC033 | 2-dehydro-3-deoxygalactonokinase | [c]2dh3dgal + atp --> 2dh3dgal6p + adp + h | Alternate Carbon Metabolism | EC-2.7.1.58
0.0015 | 0.003 | 0 | EC032 | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase | [c]2dh3dgal6p <==> g3p + pyr | Alternate Carbon Metabolism | EC-4.1.2.21
0.0015 | 0.003 | 0 | EC031 | galactonate dehydratase | [c]galctn-D --> 2dh3dgal + h2o | Alternate Carbon Metabolism | EC-4.2.1.6
0.0015 | 0.002 | 0.001 | R07153 | 2-dehydro-D-gluconate:acceptor 2-oxidoreductase | 2-Dehydro-D-gluconate + Acceptor <=> 2,5-Didehydro-D-gluconate + Reduced acceptor |  | 1.1.99.4
0.0015 | 0.002 | 0.001 | R05823 | 2-dehydro-D-gluconate:NADP+ 2-oxidoreductase | 2-Dehydro-D-gluconate + NADP+ <=> 2,5-Didehydro-D-gluconate + NADPH + H+ |  | 1.1.1.274
0.0015 | 0.002 | 0.001 | R05714 | glutathione:NADP+ oxidoreductase (CoA-acylating) | CoA + Glutathione + NADP+ <=> CoA-glutathione + NADPH + H+ |  | 1.8.1.10
0.0015 | 0.002 | 0.001 | [NAME] | (R)-Malate hydro-lyase | (R)-Malate <=> Maleic acid + H2O | Butanoate metabolism | 4.2.1.31
0.0015 | 0.002 | 0.001 | R01706 | Oleoyl-[acyl-carrier-protein] hydrolase | Hexadecanoyl-[acp] + H2O <=> Acyl-carrier protein + Hexadecanoic acid | Fatty acid biosynthesis | 2.3.1.85        3.1.2.14
0.0015 | 0.002 | 0.001 | R01608 | 3-hydroxypropanoate:NAD+ oxidoreductase | 3-Hydroxypropanoate + NAD+ <=> 3-Oxopropanoate + NADH + H+ | beta-Alanine metabolism,Propanoate metabolism | 1.1.1.59
0.0015 | 0.002 | 0.001 | [NAME] | [NAME] 3\',5\'-cyclic phosphate 5\'-nucleotidohydrolase | 3\',5\'-Cyclic GMP + H2O <=> GMP | Purine metabolism | 3.1.4.17        3.1.4.35
0.0015 | 0.002 | 0.001 | R01111 | Coenzyme A:oxidized-glutathione oxidoreductase | Oxidized glutathione + CoA <=> CoA-glutathione + Glutathione | Glutathione metabolism | 1.8.4.3
0.0015 | 0.002 | 0.001 | R01087 | Maleate cis-trans-isomerase | Maleic acid <=> Fumarate | Butanoate metabolism,Nicotinate and nicotinamide metabolism | 5.2.1.1
0.0015 | 0.002 | 0.001 | R00954 | GTP:alpha-D-glucose-1-phosphate guanylyltransferase | GTP + D-Glucose 1-phosphate <=> Pyrophosphate + GDP-glucose | Starch and sucrose metabolism | 2.7.7.34
0.0015 | 0.002 | 0.001 | R00639 | Alkan-1-ol dehydrogenase (acceptor) | Primary alcohol + Acceptor <=> [NAME] acceptor | Fatty acid metabolism | 1.1.99.8        1.1.99.9        1.1.99.20
0.0015 | 0.002 | 0.001 | R00434 | GTP pyrophosphate-lyase (cyclizing) | GTP <=> 3\',5\'-Cyclic GMP + Pyrophosphate | Purine metabolism | 4.6.1.1         4.6.1.2
0.0015 | 0.002 | 0.001 | R00215 | (R)-Malate:NAD+ oxidoreductase (decarboxylating) | (R)-Malate + NAD+ <=> Pyruvate + CO2 + NADH | Butanoate metabolism | 1.1.1.83
0.0015 | 0.002 | 0.001 | [NAME] | [NAME] phosphohydrolase | Triphosphate + H2O <=> Pyrophosphate + Orthophosphate |  | 3.6.1.25
0.0015 | 0.002 | 0.001 | R00092 | NADH:Fe2+ oxidoreductase | NAD+ + 2 Fe2+ <=> NADH + H+ + 2 Fe3+ |  | 1.16.1.7
0.0015 | 0.002 | 0.001 | EC505 | adenosylhomocysteinase | [c]ahcys + h2o <==> adn + hcys-L | [NAME] | [NAME]
0.0015 | 0.002 | 0.001 | EC497 | Fatty acid oxidation (n-C16:0) | [c]atp + (8) coa + (7) fad + (7) h2o + hdca + (7) nad --> (8) accoa + amp + (7) fadh2 + (7) h + (7) nadh + ppi | Membrane Lipid Metabolism
0.0015 | 0.001 | 0.002 | R05185 | reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) | 16 ATP + Nitrogen + 8 Reduced ferredoxin + 8 H+ + 16 H2O <=> 16 Orthophosphate + 16 ADP + 8 Oxidized ferredoxin + 2 NH3 + Hydrogen | Nitrogen metabolism | 1.18.6.1
0.0015 | 0.001 | 0.002 | R01849 | Reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) | Hydrogen + 2 NH3 + 16 Orthophosphate + 16 ADP <=> Nitrogen + 8 e- + 16 ATP + 16 H2O + 8 H+ |  | 1.18.6.1
0.0015 | 0.001 | 0.002 | R00642 | L-Ascorbate:hydrogen-peroxide oxidoreductase | Ascorbate + H2O2 <=> Dehydroascorbate + 2 H2O |  | 1.11.1.11
0.0015 | 0.001 | 0.002 | R00623 | primary_alcohol:NAD+ oxidoreductase | Primary alcohol + NAD+ <=> [NAME] H+ | Fatty acid metabolism | 1.1.1.1         1.1.1.71
0.0015 | 0.001 | 0.002 | R00002 | Reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) | 16 ATP + 16 H2O <=> 8 e- + 8 H+ + 16 Orthophosphate + 16 ADP |  | 1.18.6.1
0.0015 | 0 | 0.003 | R07135 | [NAME]:NAD+ 1-oxidoreductase | [NAME] + NAD+ <=> D-Mannose + NADH + H+ |  | 1.1.1.255
0.0015 | 0 | 0.003 | R03250 |  | 5-Amino-2-oxopentanoic acid + Urea <=> 5-Guanidino-2-oxopentanoate + H2O | D-Arginine and D-ornithine metabolism
0.0015 | 0 | 0.003 | R03099 |  | L-2-Aminoadipate + ATP + H2O <=> L-2-Aminoadipate adenylate + 2 Orthophosphate
0.0015 | 0 | 0.003 | R03098 | L-2-Aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase | L-2-Aminoadipate + ATP <=> L-2-Aminoadipate adenylate + Pyrophosphate | Lysine biosynthesis | 1.2.1.31
0.0015 | 0 | 0.003 | R02253 | trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating) | trans-Cinnamate + Oxygen + NADPH + H+ <=> 4-Coumarate + NADP+ + H2O | Phenylalanine metabolism,Stilbene, coumarine and lignin biosynthesis | 1.14.13.11
0.0015 | 0 | 0.003 | R01426 |  | Benzoate + Acetate + NADH + H+ <=> trans-Cinnamate + 2 H2O + NAD+ | Phenylalanine metabolism
0.0015 | 0 | 0.003 | R01203 | N-Acyl-D-hexosamine:oxygen 1-oxidoreductase | N-Acetyl-D-glucosamine + Oxygen + H2O <=> N-Acetyl-D-glucosaminate + H2O2 |  | 1.1.3.29
0.0015 | 0 | 0.003 | R01202 | N-Acetyl-D-glucosamine:NAD+ 1-oxidoreductase | N-Acetyl-D-glucosamine + NAD+ + H2O <=> N-Acetyl-D-glucosaminate + NADH + H+ |  | 1.1.1.240
0.0015 | 0 | 0.003 | R00978 | 5,6-Dihydrouracil:NADP+ oxidoreductase | 5,6-Dihydrouracil + NADP+ <=> Uracil + NADPH + H+ | Pyrimidine metabolism,beta-Alanine metabolism,Pantothenate and CoA biosynthesis | 1.3.1.2
0.0015 | 0 | 0.003 | R00558 | L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) | L-Arginine + Oxygen + NADPH <=> N-(omega)-Hydroxyarginine + NADP+ + H2O | Arginine and proline metabolism | 1.14.13.39
0.0015 | 0 | 0.003 | R00331 | ATP:nucleoside-diphosphate phosphatransferase | ATP + NDP <=> ADP + Nucleoside triphosphate |  | 2.7.4.6
0.0015 | 0 | 0.003 | R00111 | N-(omega)-Hydroxyarginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) | NADPH + 2 N-(omega)-Hydroxyarginine + Oxygen + H+ <=> NADP+ + 2 Nitric oxide + 2 L-Citrulline | Arginine and proline metabolism | 1.14.13.39
0.001 | 0.002 | 0 | R07244 | S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase | S-Adenosyl-L-methionine + N,N-Dimethylglycine <=> S-Adenosyl-L-homocysteine + Betaine |  | 2.1.1.157
0.001 | 0.002 | 0 | R07144 | D-arabinitol:NADP+ oxidoreductase | D-Arabitol + NADP+ <=> D-Ribulose + NADPH + H+ |  | 1.1.1.287
0.001 | 0.002 | 0 | R06982 | S-(hydroxymethyl)glutathione synthase | Glutathione + Formaldehyde <=> S-(Hydroxymethyl)glutathione | Methane metabolism | 4.4.1.22
0.001 | 0.002 | 0 | R06870 | Phosphoethanolamine phosphohydrolase | Ethanolamine phosphate + H2O <=> [NAME] | Glycerophospholipid metabolism | 3.1.3.75
0.001 | 0.002 | 0 | R05767 | trehalose 6-phosphate:phosphate b-D-glucosyltransferase | alpha,alpha\'-Trehalose 6-phosphate + Orthophosphate <=> D-Glucose 6-phosphate + beta-D-Glucose 1-phosphate |  | 2.4.1.216
0.001 | 0.002 | 0 | R05554 | Ureidoglycine aminohydrolase | Ureidoglycine + H2O <=> (-)-Ureidoglycolate + NH3 | Purine metabolism | 3.5.3.9
0.001 | 0.002 | 0 | R03046 | beta-Alanyl-CoA cmmonia-lyase | beta-Alanyl-CoA <=> Propenoyl-CoA + NH3 | beta-Alanine metabolism,Propanoate metabolism | 4.3.1.6
0.001 | 0.002 | 0 | R02821 | Trimethylaminoacetate:L-homosysteine S-methyltransferase | [NAME] <=> N,N-Dimethylglycine + L-Methionine | Glycine, serine and threonine metabolism,[NAME] metabolism | 2.1.1.5
0.001 | 0.002 | 0 | R02765 | (R)-2-Methyl-3-oxopropanoyl-CoA 2-epimerase | (R)-2-Methyl-3-oxopropanoyl-CoA <=> (S)-2-Methyl-3-oxopropanoyl-CoA | [NAME], leucine and isoleucine degradation,Propanoate metabolism | 5.1.99.1
0.001 | 0.002 | 0 | R02423 | Allantoate amidinohydrolase (decarboxylating) | Allantoate + H2O <=> Ureidoglycine + NH3 + CO2 | Purine metabolism | 3.5.3.9
0.001 | 0.002 | 0 | R01915 | Spermidine:(acceptor) oxidoreductase | [NAME] <=> 1,3-Diaminopropane + 4-Aminobutanal + Reduced acceptor | Arginine and proline metabolism | 1.5.99.6
0.001 | 0.002 | 0 | R00914 |  | beta-Alanine + CoA <=> beta-Alanyl-CoA + H2O | Propanoate metabolism
0.001 | 0.002 | 0 | R00527 | S-Formylglutathione hydrolase | S-Formylglutathione + H2O <=> Formate + Glutathione | Methane metabolism | 3.1.2.12
0.001 | 0.002 | 0 | R00488 | N-Acetyl-L-aspartate amidohydrolase | N-Acetyl-L-aspartate + H2O <=> Acetate + L-Aspartate | Alanine and aspartate metabolism | 3.5.1.15
0.001 | 0.002 | 0 | R00487 | Acetyl-CoA:L-aspartate N-acetyltransferase | Acetyl-CoA + L-Aspartate <=> CoA + N-Acetyl-L-aspartate |  | 2.3.1.17
0.001 | 0.002 | 0 | EC615 | D-lactate dehydrogenase | [c]lac-D + q8 --> pyr + q8h2 | Oxidative phosphorylation | EC-1.1.2.4
0.001 | 0.002 | 0 | EC519 | Allantoate amidohydrolase | [c]alltt + h2o --> urdglyc + urea | Nitrogen | EC-3.5.3.4
0.001 | 0.002 | 0 | EC384 | pyridoxamine 5'-phosphate oxidase | [c]h2o + o2 + pyam5p --> h2o2 + nh4 + pydx5p | Cofactor and Prosthetic Group Biosynthesis | EC-1.4.3.5
0.001 | 0.002 | 0 | EC151 | Putrescine Transaminase | [c]akg + ptrc --> 4abutn + glu-L | Arginine and Proline Metabolism
0.001 | 0.002 | 0 | EC136 | 2-dehydro-D-gluconate reductase (NADH) | [c]2dhglcn + h + nadh --> glcn + nad | Alternate Carbon Metabolism
0.001 | 0.002 | 0 | EC128 | xylulokinase | [c]atp + xylu-D --> adp + h + xu5p-D | Alternate Carbon Metabolism | EC-2.7.1.17
0.001 | 0.002 | 0 | EC116 | trehalose-6-phosphate hydrolase | [c]h2o + tre6p --> g6p + glc-D | Alternate Carbon Metabolism | EC-3.2.1.93
0.001 | 0.002 | 0 | EC108 | Methylmalonyl-CoA mutase | [c]succoa --> mmcoa-R | Alternate Carbon Metabolism | EC-5.4.99.2
0.001 | 0.002 | 0 | EC025 | Acetyl-CoA:butyrate-CoA transferase | [c]accoa + but --> ac + btcoa | Alternate Carbon Metabolism | EC-2.8.3.8
0.001 | 0.002 | 0 | EC020 | aldehyde dehydrogenase (acetaldehyde, NAD) | [c]acald + h2o + nad --> ac + (2) h + nadh | Alternate Carbon Metabolism | EC-1.2.1.3
0.001 | 0.002 | 0 | EC017 | lactaldehyde dehydrogenase | [c]h2o + lald-L + nad --> (2) h + lac-L + nadh | Alternate Carbon Metabolism | EC-1.2.1.22
0.001 | 0.002 | 0 | EC014 | methylmalonyl-CoA epimerase | [c]mmcoa-R <==> mmcoa-S | Alternate Carbon Metabolism | EC-5.1.99.1
0.001 | 0.002 | 0 | EC004 | L-asparaginase | [c]asn-L + h2o --> asp-L + nh4 | Alanine and aspartate metabolism | [NAME]
0.001 | 0.001 | 0.001 | R07384 |  | O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP <=> 1-Alkenyl-2-acylglycerol + CDP-ethanolamine | Ether lipid metabolism | 2.7.8.1
0.001 | 0.001 | 0.001 | R07220 | deoxycholate:FAD oxidoreductase (7alpha-dehydroxylating) | 3alpha,12alpha-Dihydroxy-5beta-cholanate + FAD + H2O <=> 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + FADH2 |  | 1.17.99.5
0.001 | 0.001 | 0.001 | R05836 |  | 3alpha,12alpha-Dihydroxy-5beta-chol-6-enoate + 2 H+ <=> 3alpha,12alpha-Dihydroxy-5beta-cholanate | Bile acid biosynthesis
0.001 | 0.001 | 0.001 | R05817 | (3Z)-phycocyanobilin:ferredoxin oxidoreductase | [NAME] ferredoxin <=> (3Z)-Phycocyanobilin + Oxidized ferredoxin | Porphyrin and chlorophyll metabolism | 1.3.7.5
0.001 | 0.001 | 0.001 | R05712 | ammonia:ferricytochrome-c oxidoreductase | NH3 + 2 H2O + 6 Ferricytochrome c <=> Nitrite + 6 Ferrocytochrome c + 7 H+ | Nitrogen metabolism | 1.7.2.2
0.001 | 0.001 | 0.001 | R05651 | acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming) | Sulfoacetaldehyde + Orthophosphate <=> Acetyl phosphate + Sulfite | Taurine and hypotaurine metabolism | 2.3.3.15
0.001 | 0.001 | 0.001 | R05040 |  | (3Z)-Phycocyanobilin + Acceptor <=> (3Z)-Phytochromobilin + Reduced acceptor + 2 H+ | Porphyrin and chlorophyll metabolism
0.001 | 0.001 | 0.001 | R04969 | Hexadecanoyl-[acyl-carrier protein]:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing) | Hexadecanoyl-[acp] + NAD+ <=> trans-Hexadec-2-enoyl-[acp] + NADH | Fatty acid biosynthesis | 1.3.1.9         2.3.1.86
0.001 | 0.001 | 0.001 | R04788 |  | Phytofluene + Acceptor <=> zeta-Carotene + Hydrogen + Reduced acceptor | Biosynthesis of steroids
0.001 | 0.001 | 0.001 | R04787 |  | Phytofluene <=> zeta-Carotene | Biosynthesis of steroids | 1.3.99.-
0.001 | 0.001 | 0.001 | R03913 | NADH:protein-disulfide oxidoreductase | Protein dithiol + NAD+ <=> Protein disulfide + NADH + H+ |  | 1.8.1.8
0.001 | 0.001 | 0.001 | R03678 | (3Z)-phytochromobilin:ferredoxin oxidoreductase | (3Z)-Phytochromobilin + Oxidized ferredoxin <=> [NAME] ferredoxin | Porphyrin and chlorophyll metabolism | 1.3.7.4
0.001 | 0.001 | 0.001 | [NAME] | kynurenate:oxygen oxidoreductase (hydroxylating) | 4-Hydroxy-2-quinolinecarboxylic acid + Oxygen + NADPH + H+ <=> 7,8-Dihydro-7,8-dihydroxykynurenate + NADP+ | Tryptophan metabolism | 1.14.99.2
0.001 | 0.001 | 0.001 | R03249 |  | 5-Amino-2-oxopentanoic acid <=> 1-Pyrroline-2-carboxylate + H2O | Arginine and proline metabolism,D-Arginine and D-ornithine metabolism
0.001 | 0.001 | 0.001 | R03158 |  | 3-Hydroxypropanoate + CoA <=> 3-Hydroxypropionyl-CoA + H2O | beta-Alanine metabolism,Propanoate metabolism | 3.1.2.4
0.001 | 0.001 | 0.001 | [NAME] | D-Proline:oxygen oxidoreductase (deaminating) | D-Proline + Oxygen <=> 1-Pyrroline-2-carboxylate + H2O2 | Arginine and proline metabolism | 1.4.3.3
0.001 | 0.001 | 0.001 | [NAME] |  | 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate <=> 3alpha,12alpha-Dihydroxy-5beta-chol-6-enoate + H2O | Bile acid biosynthesis
0.001 | 0.001 | 0.001 | R02737 | UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase | UDP-glucose + alpha-D-Glucose 6-phosphate <=> UDP + alpha,alpha\'-Trehalose 6-phosphate | Starch and sucrose metabolism | 2.4.1.15
0.001 | 0.001 | 0.001 | R02259 | Propane-1,2-diol:NADP+ oxidoreductase | Propane-1,2-diol + NADP+ <=> (S)-Lactaldehyde + NADPH + H+ |  | 1.1.1.55
0.001 | 0.001 | 0.001 | R02168 | GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase | GDP-glucose + D-Glucose 6-phosphate <=> GDP + alpha,alpha\'-Trehalose 6-phosphate |  | 2.4.1.36
0.001 | 0.001 | 0.001 | R01908 | Oxalyl-CoA carboxy-lyase | Oxalyl-CoA <=> Formyl-CoA + CO2 | Glyoxylate and dicarboxylate metabolism | 4.1.1.8
0.001 | 0.001 | 0.001 | R01809 | N-Acetylneuraminate,hydrogen-donor:oxygen oxidoreductase (N-acetyl-hydroxylating) | N-Acetylneuraminate + Reduced acceptor + Oxygen <=> N-Glycoloyl-neuraminate + Acceptor + H2O
0.001 | 0.001 | 0.001 | R01682 | 3-Sulfoalanine carboxy-lyase | L-Cysteate <=> Taurine + CO2 | Taurine and hypotaurine metabolism | 4.1.1.15        4.1.1.29
0.001 | 0.001 | 0.001 | R01281 | Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) | Palmitoyl-CoA + L-Serine <=> 3-Dehydrosphinganine + CoA + CO2 | Sphingolipid metabolism | 2.3.1.50
0.001 | 0.001 | 0.001 | R01255 | L-Proline racemase | L-Proline <=> D-Proline | Arginine and proline metabolism | 5.1.1.4
0.001 | 0.001 | 0.001 | R01108 | Glutathione:dehydroascorbate oxidoreductase | L-Dehydroascorbate + 2 Glutathione <=> Oxidized glutathione + Ascorbate | Ascorbate and aldarate metabolism | 1.8.5.1
0.001 | 0.001 | 0.001 | R01025 | Choline:(acceptor) 1-oxidoreductase | [NAME] <=> [NAME] aldehyde + Reduced acceptor | Glycine, serine and threonine metabolism | 1.1.99.1
0.001 | 0.001 | 0.001 | R00901 | L-Cysteine hydrogen-sulfide-lyase (adding sulfite) | L-Cysteine + Sulfite <=> Hydrogen sulfide + L-Cysteate | Cysteine metabolism,Taurine and hypotaurine metabolism | 4.4.1.10
0.001 | 0.001 | 0.001 | R00729 | L-Tyrosine:oxygen oxidoreductase (deaminating) | L-Tyrosine + H2O + Oxygen <=> 3-(4-Hydroxyphenyl)pyruvate + NH3 + H2O2 | Tyrosine metabolism,[NAME], tyrosine and tryptophan biosynthesis,Alkaloid biosynthesis I | 1.4.3.2
0.001 | 0.001 | 0.001 | R00100 | NADH:ferricytochrome-b5 oxidoreductase | NADH + 2 Ferricytochrome b5 + H+ <=> NAD+ + 2 Ferrocytochrome b5 | Aminosugars metabolism | 1.6.2.2
0.001 | 0.001 | 0.001 | R00095 | NADH:monodehydroascorbate oxidoreductase | NAD+ + 2 Ascorbate <=> NADH + 2 Monodehydroascorbate + H+ | Ascorbate and aldarate metabolism | 1.6.5.4
0.001 | 0.001 | 0.001 | R00078 | Fe(II):oxygen oxidoreductase | Oxygen + 4 Fe2+ + 4 H+ <=> 4 Fe3+ + 2 H2O | Porphyrin and chlorophyll metabolism | 1.16.3.1
0.001 | 0.001 | 0.001 | EC182 | 1-pyrroline-5-carboxylate dehydrogenase | [c]1pyr5c + (2) h2o + nad --> glu-L + h + nadh | Arginine and Proline Metabolism | EC-1.5.1.12
0.001 | 0 | 0.002 | R07181 | hydrogen:NADP+ oxidoreductase | Hydrogen + NADP+ <=> NADPH + H+ |  | 1.12.1.2
0.001 | 0 | 0.002 | R05698 | [NAME]:oxygen oxidoreductase (cyclizing) | [NAME] <=> D-Mannose + H2O2 |  | 1.1.3.40
0.001 | 0 | 0.002 | R05641 | ergosterol:NADP+ D24(241)-oxidoreductase | [NAME] <=> Ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+ |  | 1.3.1.71
0.001 | 0 | 0.002 | [NAME] | [NAME] glucohydrolase | [NAME] H2O <=> Salicyl alcohol + beta-D-Glucose 6-phosphate | Glycolysis / Gluconeogenesis | 3.2.1.86
0.001 | 0 | 0.002 | R04661 |  | CMP-N-acetylneuraminate + N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosylceramide <=> CMP + GT1b |  | 2.4.99.8
0.001 | 0 | 0.002 | R04649 |  | CMP-N-acetylneuraminate + D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D- galactosyl-D-glucosylceramide <=> CMP + GD1b |  | 2.4.99.8
0.001 | 0 | 0.002 | R04586 | N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D- glucosylceramide N-acetylhexosaminohydrolase | N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D- glucosylceramide + H2O <=> GM3 + N-Acetyl-D-galactosamine |  | 3.2.1.52
0.001 | 0 | 0.002 | R04452 | 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase | 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-Organyl-2-lyso-sn-glycero-3-phosphocholine + Acetate | Ether lipid metabolism | 3.1.1.47
0.001 | 0 | 0.002 | R04394 | Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase | Protein N(pi)-phospho-L-histidine [NAME] <=> Protein histidine + Salicin 6-phosphate | Glycolysis / Gluconeogenesis | 2.7.1.69
0.001 | 0 | 0.002 | R03676 |  | Ergosterol + Acceptor <=> Ergosta-5,7,22,24(28)-tetraen-3beta-ol + Reduced acceptor + 2 H+ | Biosynthesis of steroids
0.001 | 0 | 0.002 | R03558 | UDPglucose:salicyl-alcohol beta-D-glucosyltransferase | UDP-glucose + Salicyl alcohol <=> UDP + Salicin |  | 2.4.1.172
0.001 | 0 | 0.002 | R03492 | beta-D-Galactosyl-1,4-beta-D-glucosylceramide N-acetylhexosaminohydrolase | GA2 + H2O <=> beta-D-Galactosyl-1,4-beta-D-glucosylceramide + N-Acetyl-D-galactosamine |  | 3.2.1.52
0.001 | 0 | 0.002 | R03437 | Acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase | Acetyl-CoA + 1-Organyl-2-lyso-sn-glycero-3-phosphocholine <=> CoA + 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine | Ether lipid metabolism | 2.3.1.67
0.001 | 0 | 0.002 | R02956 | Succinyl-CoA:citramalate CoA-transferase | Succinyl-CoA + Citramalate <=> Succinate + Citramalyl-CoA |  | 2.8.3.7
0.001 | 0 | 0.002 | R02955 | Acetyl-CoA:citramalate CoA-transferase | Acetyl-CoA + Citramalate <=> Acetate + (3S)-Citramalyl-CoA |  | 2.8.3.11
0.001 | 0 | 0.002 | R02925 | D-Sorbitol:(acceptor) 1-oxidoreductase | D-Sorbitol + FAD <=> FADH2 + L-Sorbose | Fructose and mannose metabolism | 1.1.99.21
0.001 | 0 | 0.002 | R02730 | D-Fructose-2,6-bisphosphate 6-phosphohydrolase | beta-D-Fructose 2,6-bisphosphate + H2O <=> beta-D-Fructose 2-phosphate + Orthophosphate | Fructose and mannose metabolism | 3.1.3.54
0.001 | 0 | 0.002 | R02491 | L-Citramalyl-CoA hydro-lyase | (3S)-Citramalyl-CoA <=> Itaconyl-CoA + H2O | C5-Branched dibasic acid metabolism | 4.2.1.56
0.001 | 0 | 0.002 | R02490 | Citramalyl-CoA hydro-lyase | Citramalyl-CoA <=> Itaconyl-CoA + H2O |  | 4.2.1.56
0.001 | 0 | 0.002 | R01770 | Inosine ribohydrolase | Inosine + H2O <=> Hypoxanthine + D-Ribose | Purine metabolism | 3.2.2.1         3.2.2.2         3.2.2.8
0.001 | 0 | 0.002 | R01711 | Pyridoxine:oxygen oxidoreductase (deaminating) | Pyridoxine + Oxygen <=> Pyridoxal + H2O2 | [NAME] metabolism | 1.1.3.12        1.4.3.5
0.001 | 0 | 0.002 | R01708 | Pyridoxine:NADP+ 4-oxidoreductase | Pyridoxine + NADP+ <=> Pyridoxal + NADPH + H+ | [NAME] metabolism | 1.1.1.65
0.001 | 0 | 0.002 | R01555 | Maltose:orthophosphate 1-beta-D-glucosyltransferase | [NAME] <=> D-Glucose + beta-D-Glucose 1-phosphate | Starch and sucrose metabolism | 2.4.1.8
0.001 | 0 | 0.002 | R01295 | benzoate,NADPH:oxygen oxidoreductase(4-hydroxylating) | Benzoate + Oxygen + NADPH + H+ <=> 4-Hydroxybenzoate + NADP+ + H2O | Benzoate degradation via hydroxylation,Benzoate degradation via CoA ligation | 1.14.13.12
0.001 | 0 | 0.002 | [NAME] | P1,P4-Bis(5\'-nucleosyl)-tetraphosphate nucleotidohydrolase | P1,P4-Bis(5\'-guanosyl) tetraphosphate + H2O <=> GTP + GMP | Purine metabolism | 3.6.1.17
0.001 | 0 | 0.002 | R00885 | GTP:alpha-D-mannose-1-phosphate guanylyltransferase | GTP + D-Mannose 1-phosphate <=> Pyrophosphate + GDP-mannose | Fructose and mannose metabolism | 2.7.7.13
0.001 | 0 | 0.002 | R00881 | GDPmannose sugarphosphohydrolase | GDP-mannose + H2O <=> GMP + D-Mannose 1-phosphate | Fructose and mannose metabolism | 3.6.1.21
0.001 | 0 | 0.002 | [NAME] | D-Fructose 2-phosphate phosphatase | beta-D-Fructose 2-phosphate + H2O <=> D-Fructose + Orthophosphate | Fructose and mannose metabolism | 3.1.3.-
0.001 | 0 | 0.002 | R00865 | D-Mannitol:ferricytochrome-c 2-oxidoreductase | Mannitol + 2 Ferricytochrome c <=> D-Fructose + 2 Ferrocytochrome c | Fructose and mannose metabolism | 1.1.2.2
0.001 | 0 | 0.002 | R00825 | Anthranilate,NADPH:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating) | Anthranilate + Oxygen + NADPH + H+ <=> Catechol + NH3 + CO2 + NADP+ | Benzoate degradation via hydroxylation,Carbazole degradation,Nitrogen metabolism | 1.14.12.1
0.001 | 0 | 0.002 | R00813 | cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase | 1,6-Dihydroxy-cis-2,4-cyclohexadiene-1-carboxylic acid + NAD+ <=> Catechol + NADH + CO2 + H+ | Benzoate degradation via hydroxylation,Benzoate degradation via CoA ligation | 1.3.1.25
0.001 | 0 | 0.002 | R00363 | Oxaloacetate keto-enol-isomerase | Oxaloacetate <=> 2-Hydroxyethylenedicarboxylate |  | 5.3.2.2
0.001 | 0 | 0.002 | R00219 |  | Pyruvate + CO2 <=> 2-Hydroxyethylenedicarboxylate | Pyruvate metabolism | 4.1.1.-
0.001 | 0 | 0.002 | R00040 | Choline:oxygen 1-oxidoreductase | Oxygen + 2 Choline <=> 2 Betaine aldehyde + 2 H2O | Glycine, serine and threonine metabolism | 1.1.3.17
0.001 | 0 | 0.002 | R00012 | GTP:GTP guanylyltransferase | 2 GTP <=> Pyrophosphate + P1,P4-Bis(5\'-guanosyl) tetraphosphate |  | 2.7.7.45
0.001 | 0 | 0.002 | EC092 | glucosamine-6-phosphate deaminase | [c]gam6p + h2o --> f6p + nh4 | Alternate Carbon Metabolism | EC-3.5.99.6
0.0005 | 0.001 | 0 | R07381 | Plasmenylethanolamine ethanolamine phosphohydrolase | O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-Alkenyl-2-acylglycerol + Ethanolamine phosphate | Ether lipid metabolism | 3.1.4.3
0.0005 | 0.001 | 0 | R07290 | formyl-CoA:oxalate CoA-transferase | Formyl-CoA + Oxalate <=> Formate + Oxalyl-CoA |  | 2.8.3.16
0.0005 | 0.001 | 0 | R07229 | selenite:reduced acceptor oxidoreductase | Selenite + H2O + Acceptor <=> Selenate + Reduced acceptor |  | 1.97.1.9
0.0005 | 0.001 | 0 | R07200 | zeaxanthin,NAD(P)H:oxygen oxidoreductase | [NAME] H+ + Oxygen <=> Violaxanthin + NADP+ + H2O |  | 1.14.13.90
0.0005 | 0.001 | 0 | R07178 | violaxanthin:ascorbate oxidoreductase | Violaxanthin + Ascorbate <=> [NAME] |  | 1.10.99.3
0.0005 | 0.001 | 0 | R07143 | D-arabinitol:NADP+ oxidoreductase | D-Arabitol + NADP+ <=> D-Xylulose + NADPH + H+ |  | 1.1.1.287
0.0005 | 0.001 | 0 | R07140 | S-(hydroxymethyl)glutathione:NADP+ oxidoreductase | S-(Hydroxymethyl)glutathione + NADP+ <=> S-Formylglutathione + NADPH + H+ |  | 1.1.1.284
0.0005 | 0.001 | 0 | R06983 | S-(hydroxymethyl)glutathione dehydrogenase | S-(Hydroxymethyl)glutathione + NAD+ <=> S-Formylglutathione + NADH + H+ | Methane metabolism | 1.1.1.284
0.0005 | 0.001 | 0 | R05492 |  | 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane + Oxygen <=> cis-2,3-Dihydrodiol 1,1,1-Trichloro-2,2-bis(4\'-chlorophenyl)ethane | 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT), | 1.14.99.-
0.0005 | 0.001 | 0 | R05260 |  | 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane + Reduced acceptor + Oxygen <=> cis-2,3-Dihydrodiol 1,1,1-Trichloro-2,2-bis(4\'-chlorophenyl)ethane + Acceptor
0.0005 | 0.001 | 0 | R04929 | ATP:sulfate adenylyltransferase | ATP + Selenate <=> Pyrophosphate + Adenylylselenate | Selenoamino acid metabolism | 2.7.7.4
0.0005 | 0.001 | 0 | R04927 | AMP,sulfite:(acceptor) oxidoreductase | Ferricytochrome c + Selenite + AMP <=> Ferrocytochrome c + Adenylylselenate | Selenoamino acid metabolism | 1.8.99.2
0.0005 | 0.001 | 0 | R04584 | (N-Acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase | UDP-N-acetyl-D-galactosamine + GM3 <=> UDP + N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D- glucosylceramide |  | 2.4.1.92
0.0005 | 0.001 | 0 | [NAME] | 3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) | ATP + 3-Methylcrotonyl-CoA + HCO3- <=> ADP + Orthophosphate + 3-Methylglutaconyl-CoA | [NAME], leucine and isoleucine degradation | 6.4.1.4
0.0005 | 0.001 | 0 | R04097 |  | 3-Methylbutanoyl-CoA + Dihydrolipoamide <=> S-(3-Methylbutanoyl)-dihydrolipoamide + CoA | [NAME], leucine and isoleucine degradation | 2.3.1.-
0.0005 | 0.001 | 0 | R03490 | UDP-N-Acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl--D- glucosylceramide N-acetyl-D-galactrosaminyltransferase | UDP-N-acetyl-D-galactosamine + beta-D-Galactosyl-1,4-beta-D-glucosylceramide <=> UDP + GA2 |  | 2.4.1.92
0.0005 | 0.001 | 0 | R03405 | 3\'-phosphoadenylylsulfate:alcohol sulfotransferase | 3\'-Phosphoadenylyl sulfate + 3beta-Hydroxyandrost-5-en-17-one <=> Adenosine 3\',5\'-bisphosphate + 3beta-Hydroxyandrost-5-en-17-one 3-sulfate | Androgen and estrogen metabolism | 2.8.2.2
0.0005 | 0.001 | 0 | R03404 | 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase | 3beta-Hydroxyandrost-5-en-17-one 3-sulfate + H2O <=> 3beta-Hydroxyandrost-5-en-17-one + Sulfate | Androgen and estrogen metabolism | 3.1.6.2
0.0005 | 0.001 | 0 | R03270 | 2-(alpha-Hydroxyethyl)thiamine diphosphate:lipoamide 2-oxidoreductase(decarboxylating and acceptor-acetylating) | 2-(alpha-Hydroxyethyl)thiamine diphosphate + Lipoamide <=> S-Acetyldihydrolipoamide + Thiamin diphosphate | Glycolysis / Gluconeogenesis | 1.2.4.1
0.0005 | 0.001 | 0 | R03185 |  | Monodehydroascorbate + Acceptor <=> L-Dehydroascorbate + Reduced acceptor | Ascorbate and aldarate metabolism
0.0005 | 0.001 | 0 | R03181 | 4-Maleylacetoacetate cis-trans-isomerase | 4-Maleylacetoacetate <=> 4-Fumarylacetoacetate | Tyrosine metabolism,[NAME] degradation | 5.2.1.2
0.0005 | 0.001 | 0 | R03157 |  | 3-Hydroxypropionyl-CoA + Orthophosphate + ADP <=> 3-Hydroxypropanoate + CoA + ATP | Propanoate metabolism | 3.1.2.4         6.2.1.-
0.0005 | 0.001 | 0 | R03064 | acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase | [NAME] <=> Deacetylcephalosporin C + Acetyl-CoA | Penicillins and cephalosporins biosynthesis | 2.3.1.175
0.0005 | 0.001 | 0 | R03062 | Cephalosporin-C acetylhdrolase | Cephalosporin C + H2O <=> Deacetylcephalosporin C + Acetate | Penicillins and cephalosporins biosynthesis | 3.1.1.41
0.0005 | 0.001 | 0 | R02978 | Sphinganine:NADP+ 3-oxidoreductase | Sphinganine + NADP+ <=> 3-Dehydrosphinganine + NADPH + H+ | Sphingolipid metabolism | 1.1.1.102
0.0005 | 0.001 | 0 | R02976 | ATP:sphinganine 1-phosphotransferase | ATP + Sphinganine <=> ADP + Sphinganine 1-phosphate | Sphingolipid metabolism | 2.7.1.91
0.0005 | 0.001 | 0 | R02965 | Hydrogen:quinone oxidoreductase | Menaquinone + Hydrogen <=> Menaquinol |  | 1.12.5.1
0.0005 | 0.001 | 0 | R02964 |  | Menaquinone + 2 H+ <=> Menaquinol |  | 1.6.5.-
0.0005 | 0.001 | 0 | R02577 | Propane-1,2-diol:NAD+ 1-oxidoreductase | Propane-1,2-diol + NADP+ <=> [NAME] H+ | Glycerolipid metabolism,Pyruvate metabolism | 1.1.1.21
0.0005 | 0.001 | 0 | [NAME] | 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating) | 3-(4-Hydroxyphenyl)pyruvate + Oxygen <=> Homogentisate + CO2 | Tyrosine metabolism | 1.13.11.27
0.0005 | 0.001 | 0 | R02519 | Homogentisate:oxygen 1,2-oxidoreductase (decyclizing) | Homogentisate + Oxygen <=> 4-Maleylacetoacetate | Tyrosine metabolism,[NAME] degradation | 1.13.11.5
0.0005 | 0.001 | 0 | R02464 | Sphinganine-1-phosphate pamlmitaldehyde-lyase | Sphinganine 1-phosphate <=> Ethanolamine phosphate + Hexadecanal | Sphingolipid metabolism | 4.1.2.27
0.0005 | 0.001 | 0 | R02315 | [NAME]:NADP+ oxidoreductase | [NAME] H2O <=> L-Glutamate + L-2-Aminoadipate 6-semialdehyde + NADPH + H+ | Lysine biosynthesis,Lysine degradation | 1.5.1.10
0.0005 | 0.001 | 0 | R02302 | 5-Formiminotetrahydrofolate ammonia-lyase (cyclizing) | 5-Formiminotetrahydrofolate <=> 5,10-Methenyltetrahydrofolate + NH3 | One carbon pool by folate | 4.3.1.4
0.0005 | 0.001 | 0 | R02287 | 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase | 5-Formiminotetrahydrofolate + L-Glutamate <=> Tetrahydrofolate + N-Formimino-L-glutamate | Histidine metabolism,One carbon pool by folate | 2.1.2.5
0.0005 | 0.001 | 0 | R02085 | (S)-3-Hydroxy-3-methylglutaryl-CoA hydro-lyase | (S)-3-Hydroxy-3-methylglutaryl-CoA <=> 3-Methylglutaconyl-CoA + H2O | [NAME], leucine and isoleucine degradation | 4.2.1.18
0.0005 | 0.001 | 0 | R01986 | 4-Aminobutyraldehyde:NAD+ oxidoreductase | 4-Aminobutanal + NADP+ + H2O <=> 4-Aminobutanoate + NADPH | Arginine and proline metabolism | 1.2.1.3
0.0005 | 0.001 | 0 | R01916 | N1-Acetylspermidine amidohydrolase | N1-Acetylspermidine + H2O <=> Acetate + Spermidine |  | 3.5.1.48
0.0005 | 0.001 | 0 | R01803 | N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) | N-Acetylneuraminate + 2 Ferrocytochrome [NAME] H+ <=> N-Glycoloyl-neuraminate + 2 Ferricytochrome b5 + H2O | Aminosugars metabolism | 1.14.18.2
0.0005 | 0.001 | 0 | R01702 | 4-methyl-2-oxopentanoate:lipoamide oxidoreductase(decarboxylating and acceptor-3-methylbutanoylating) | 4-Methyl-2-oxopentanoate + Lipoamide <=> S-(3-Methylbutanoyl)-dihydrolipoamide + CO2 | [NAME], leucine and isoleucine degradation | 1.2.4.4
0.0005 | 0.001 | 0 | R01586 | Methylamine:L-glutamate N-methyltransferase | Methylamine + L-Glutamate <=> NH3 + N-Methyl-L-glutamate | Methane metabolism | 2.1.1.21
0.0005 | 0.001 | 0 | R01408 | Formamide hydro-lyase | Formamide <=> Hydrogen cyanide + H2O | Cyanoamino acid metabolism | 4.2.1.66
0.0005 | 0.001 | 0 | R01364 | 4-Fumarylacetoacetate fumarylhydrola | Acetoacetate + Fumarate <=> 4-Fumarylacetoacetate + H2O | Tyrosine metabolism,[NAME] degradation | 3.7.1.2
0.0005 | 0.001 | 0 | R01360 | (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetate-lyase | (S)-3-Hydroxy-3-methylglutaryl-CoA <=> Acetyl-CoA + Acetoacetate | Synthesis and degradation of ketone bodies,[NAME], leucine and isoleucine degradation,Butanoate metabolism | 4.1.3.4
0.0005 | 0.001 | 0 | R01358 | Acetoacetyl-CoA hydrolase | Acetoacetyl-CoA + H2O <=> Acetoacetate + CoA | Butanoate metabolism | 3.1.2.11
0.0005 | 0.001 | 0 | R01291 | S-Ribosyl-L-homocysteine ribohydrolase | S-Ribosyl-L-homocysteine + H2O <=> D-Ribose + L-Homocysteine | Methionine metabolism | 4.4.1.21
0.0005 | 0.001 | 0 | R01176 | Butanoate:CoA ligase (AMP-forming) | ATP + Butanoic acid + CoA <=> AMP + Pyrophosphate + Butanoyl-CoA | Butanoate metabolism | 6.2.1.2
0.0005 | 0.001 | 0 | R00716 | [NAME]:NADP+ oxidoreductase (L-lysine-forming) | [NAME] H2O <=> L-Lysine + 2-Oxoglutarate + NADPH + H+ | Lysine biosynthesis,Lysine degradation | 1.5.1.8
0.0005 | 0.001 | 0 | R00609 | N-Methyl-L-glutamate:(acceptor) oxidoreductase (demethylating) | N-Methyl-L-glutamate + Acceptor + H2O <=> L-Glutamate + Formaldehyde + Reduced acceptor | Methane metabolism | 1.5.99.5
0.0005 | 0.001 | 0 | R00531 | Adenylylsulfate sulfohydrolase | Adenylylsulfate + H2O <=> AMP + Sulfate | Sulfur metabolism | 3.6.2.1
0.0005 | 0.001 | 0 | R00524 | Formamide amidohydrolase | Formamide + H2O <=> Formate + NH3 | Glyoxylate and dicarboxylate metabolism,Nitrogen metabolism | 3.5.1.49
0.0005 | 0.001 | 0 | R00507 | 3\'-Phosphoadenylylsulfate nucleotidohydrolase | 3\'-Phosphoadenylyl sulfate + H2O <=> Sulfate + Adenosine 3\',5\'-bisphosphate | Purine metabolism,[NAME] metabolism | 3.6.1.9         3.6.2.2
0.0005 | 0.001 | 0 | R00367 | S-Adenosyl-L-methionine:glycine methyltransferase | S-Adenosyl-L-methionine + Glycine <=> S-Adenosyl-L-homocysteine + Sarcosine | Glycine, serine and threonine metabolism | 2.1.1.20        2.1.1.156
0.0005 | 0.001 | 0 | R00273 | oxalate:oxygen oxidoreductase | Oxalate + Oxygen <=> H2O2 + 2 CO2 | Glyoxylate and dicarboxylate metabolism | 1.2.3.4
0.0005 | 0.001 | 0 | R00148 |  | NH3 + Oxygen <=> Hydroxylamine + H2O | Nitrogen metabolism | 1.13.12.-
0.0005 | 0.001 | 0 | EC718 | lysine decarboxylase | [c]h + lys-L --> 15dap + co2 | Threonine and Lysine Metabolism | EC-4.1.1.18
0.0005 | 0.001 | 0 | EC708 | Formate-hydrogen lyase | [c]for + h --> co2 + h2 | Pyruvate metabolism
0.0005 | 0.001 | 0 | EC683 | N-acetyl-D-mannosamine kinase | [c]acmana + atp --> acmanap + adp + h | Putative | EC-2.7.1.60
0.0005 | 0.001 | 0 | EC682 | N-acetylmannosamine 6-phoshpate epimerase | [c]acmanap --> acgam6p | Putative
0.0005 | 0.001 | 0 | EC623 | glycerol-3-phosphate dehydrogenase (demethylmenaquinone-8) | [c]2dmmq8 + glyc3p --> 2dmmql8 + dhap | Oxidative phosphorylation | EC-1.1.99.5
0.0005 | 0.001 | 0 | EC619 | Trimethylamine N-oxide reductase (demethylmenaquinol 8) | [c]2dmmql8 + h + tmao --> 2dmmq8 + h2o + tma | Oxidative phosphorylation
0.0005 | 0.001 | 0 | EC607 | L-Lactate dehydrogenase (ubiquinone) | [c]lac-L + q8 --> pyr + q8h2 | Oxidative phosphorylation | EC-1.1.2.3
0.0005 | 0.001 | 0 | EC545 | Nucleoside triphosphate tripolyhydrolase | [c]gtp + h2o --> gsn + pppi | Nucleotide Salvage Pathways | EC-3.1.5.1
0.0005 | 0.001 | 0 | EC515 | hydroxyacylglutathione hydrolase | [c]h2o + lgt-S --> gthrd + h + lac-D | [NAME] | EC-3.1.2.6
0.0005 | 0.001 | 0 | EC513 | S-adenosylhomocysteine nucleosidase | [c]ahcys + h2o --> ade + rhcys | [NAME] | EC-3.2.2.9
0.0005 | 0.001 | 0 | EC448 | Glucose-1-phosphatase | [c]g1p + h2o --> glc-D + pi | Glycolysis/Gluconeogenesis | EC-3.1.3.10
0.0005 | 0.001 | 0 | EC387 | [NAME] | [c]atp + pydx --> adp + h + pydx5p | Cofactor and Prosthetic Group Biosynthesis | EC-2.7.1.35
0.0005 | 0.001 | 0 | EC292 | hypothetical enyme | [c]h2o + pyam5p --> pi + pydam | Cofactor and Prosthetic Group Biosynthesis
0.0005 | 0.001 | 0 | [NAME] | Spermidine acetyltransferase | [c]accoa + spmd --> N1aspmd + coa + h | Arginine and Proline Metabolism | EC-2.3.1.57
0.0005 | 0.001 | 0 | EC133 | Methylmalonyl-CoA decarboxylase | [c]h + mmcoa-S --> co2 + ppcoa | Alternate Carbon Metabolism | EC-4.1.1.41
0.0005 | 0.001 | 0 | EC066 | b-galactosidase | [c]h2o + lcts --> gal + glc-D | Alternate Carbon Metabolism | EC-3.2.1.23
0.0005 | 0 | 0.001 | R07385 |  | O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphate + Ethanolamine | Ether lipid metabolism | 3.1.4.4
0.0005 | 0 | 0.001 | R07383 |  | 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphate + H2O <=> 1-Alkenyl-2-acylglycerol + Orthophosphate | Ether lipid metabolism | 3.1.3.-
0.0005 | 0 | 0.001 | R06872 | Acyl-CoA:sn-glycerol-3-phosphate 2-O-acyltransferase | sn-Glycerol 3-phosphate + Acyl-CoA <=> 2-Acyl-sn-glycerol 3-phosphate + CoA | Glycerophospholipid metabolism
0.0005 | 0 | 0.001 | R05701 | Coniferyl aldehyde:NADP oxidoreductase | Coniferyl aldehyde + H2O + NADP+ <=> Ferulate + NADPH + H+ |  | 1.2.1.68
0.0005 | 0 | 0.001 | R05700 | Coniferyl aldehyde:NAD oxidoreductase | Coniferyl aldehyde + H2O + NAD+ <=> Ferulate + NADH + H+ |  | 1.2.1.68
0.0005 | 0 | 0.001 | R05622 |  | Benzoate + NADPH + H+ + Oxygen <=> 1,6-Dihydroxy-cis-2,4-cyclohexadiene-1-carboxylic acid + NADP+ | Benzoate degradation via hydroxylation,Benzoate degradation via CoA ligation | 1.14.12.10
0.0005 | 0 | 0.001 | R05621 |  | Benzoate + NADH + H+ + Oxygen <=> 1,6-Dihydroxy-cis-2,4-cyclohexadiene-1-carboxylic acid + NAD+ | Benzoate degradation via hydroxylation,Benzoate degradation via CoA ligation | 1.14.12.10
0.0005 | 0 | 0.001 | R05103 |  | 3-Ketosphingosine + CO2 + CoA <=> trans-Hexadec-2-enoyl-CoA + L-Serine
0.0005 | 0 | 0.001 | R04967 | Tetradecanoyl-[acyl-carrier protein]:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) | Tetradecanoyl-[acp] + NADP+ <=> trans-Tetradec-2-enoyl-[acp] + NADPH | Fatty acid biosynthesis | 1.3.1.10        2.3.1.85
0.0005 | 0 | 0.001 | R04966 | Tetradecanoyl-[acyl-carrier protein]:malonyl-CoA C-acyltransferase(decarboxylating, oxoacyl- and enoyl-reducing) | Tetradecanoyl-[acp] + NAD+ <=> trans-Tetradec-2-enoyl-[acp] + NADH | Fatty acid biosynthesis | 1.3.1.9         2.3.1.86
0.0005 | 0 | 0.001 | R04488 |  | 4-Carboxy-2-hydroxymuconate semialdehyde + H2O <=> 4-Carboxy-2-oxo-4-pentanoate + Formate | Benzoate degradation via hydroxylation | 3.7.1.-
0.0005 | 0 | 0.001 | R04433 | Electron-transferring-flavoprotein:ubiquinone oxidoreductase | Reduced electron-transferring flavoprotein + Ubiquinone <=> Electron-transferring flavoprotein + Ubiquinol |  | 1.5.5.1
0.0005 | 0 | 0.001 | R04432 | Propanoyl-CoA:(acceptor) 2,3-oxidoreductase | Electron-transferring flavoprotein + Propanoyl-CoA <=> Reduced electron-transferring flavoprotein + Propenoyl-CoA | Propanoate metabolism | 1.3.99.3
0.0005 | 0 | 0.001 | R04417 |  | 4-Hydroxy-4-methyl-2-oxoglutarate <=> 4-Carboxy-2-oxo-4-pentanoate + H2O | Benzoate degradation via hydroxylation | 4.2.1.-
0.0005 | 0 | 0.001 | R04215 | CTP:N-acylneuraminate cytidylyltransferase | CTP + N-Glycoloyl-neuraminate <=> Pyrophosphate + CMP-N-glycoloylneuraminate | Aminosugars metabolism | 2.7.7.43
0.0005 | 0 | 0.001 | R04200 | D-threo-2,4-diaminopentanoate:NAD+ oxidoreductase (deaminating) | (2R,4S)-2,4-Diaminopentanoate + H2O + NAD+ <=> 2-Amino-4-oxopentanoic acid + NH3 + NADH + H+ | D-Arginine and D-ornithine metabolism | 1.4.1.12
0.0005 | 0 | 0.001 | R04126 | ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase | ATP + 1-Alkyl-sn-glycerol <=> ADP + 1-Alkyl-sn-glycero-3-phosphate | Ether lipid metabolism | 2.7.1.93
0.0005 | 0 | 0.001 | R04092 |  | 3-Dehydrosphinganine + FAD <=> 3-Ketosphingosine + FADH2
0.0005 | 0 | 0.001 | R04045 |  | 2,3-Dihydroxyindole + H2O <=> Indoxyl + Oxygen | Tryptophan metabolism
0.0005 | 0 | 0.001 | R04043 | 2-Acetyl-1-alkyl-sn-glycerol acetylhydrolase | 1-Alkyl-2-acetyl-sn-glycerol + H2O <=> 1-Alkyl-sn-glycerol + Acetate |  | 3.1.1.71
0.0005 | 0 | 0.001 | R04008 |  | 4-Guanidinobutanal + CO2 <=> 2-Oxoarginine | Arginine and proline metabolism | 4.1.1.-
0.0005 | 0 | 0.001 | R03891 | Benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing) | Benzene-1,2,4-triol + [NAME] <=> 2-Maleylacetate | 1,4-Dichlorobenzene degradation | 1.13.11.37
0.0005 | 0 | 0.001 | R03455 | Acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase | Acetyl-CoA + 1-Alkyl-sn-glycero-3-phosphate <=> CoA + 2-Acetyl-1-alkyl-sn-glycero-3-phosphate | Ether lipid metabolism | 2.3.1.105
0.0005 | 0 | 0.001 | R03454 | 1-Alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase | 2-Acetyl-1-alkyl-sn-glycero-3-phosphate + H2O <=> 1-Alkyl-2-acetyl-sn-glycerol + Orthophosphate | Ether lipid metabolism | 3.1.3.59
0.0005 | 0 | 0.001 | R03316 | 3-Carboxy-1-hydroxypropyl-ThPP:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) | 3-Carboxy-1-hydroxypropyl-ThPP + Lipoamide <=> S-Succinyldihydrolipoamide + Thiamin diphosphate | Citrate cycle (TCA cycle) | 1.2.4.2
0.0005 | 0 | 0.001 | R03288 | beta-Alanyl-N(pai)-methyl-L-histidine  hydrolase | beta-Alanyl-N(pi)-methyl-L-histidine + H2O <=> beta-Alanine + N(pi)-Methyl-L-histidine | Histidine metabolism,beta-Alanine metabolism | 3.4.13.5
0.0005 | 0 | 0.001 | R03286 | N(pai)-Methyl-L-histidine:beta-alanine ligase (AMP-forming) | ATP + N(pi)-Methyl-L-histidine + beta-Alanine <=> AMP + Pyrophosphate + beta-Alanyl-N(pi)-methyl-L-histidine | Histidine metabolism,beta-Alanine metabolism | 3.4.13.20       6.3.2.11
0.0005 | 0 | 0.001 | R03276 | (S)-3-Hydroxybutanoyl-CoA 3-epimerase | (S)-3-Hydroxybutanoyl-CoA <=> ([NAME] | Butanoate metabolism | 5.1.2.3
0.0005 | 0 | 0.001 | R03178 | 2-oxo-5-Guanidinopentanoate carboxy-lyase | 5-Guanidino-2-oxopentanoate <=> 4-Guanidinobutanal + CO2 |  | 4.1.1.75
0.0005 | 0 | 0.001 | R03109 | Acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase; Acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase | Acyl-CoA + 1-(1-Alkenyl)-sn-glycero-3-phosphocholine <=> CoA + Plasmenylcholine | Ether lipid metabolism | 2.3.1.25        2.3.1.104
0.0005 | 0 | 0.001 | R03107 | Plasmenylcholine 2-acylhydrolase | Plasmenylcholine + H2O <=> 1-(1-Alkenyl)-sn-glycero-3-phosphocholine + Fatty acid anion |  | 3.1.1.4
0.0005 | 0 | 0.001 | R03045 | 3-Hydroxypropionyl-CoA hydro-lyase | 3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O | beta-Alanine metabolism,Propanoate metabolism | 4.2.1.17
0.0005 | 0 | 0.001 | R03032 | D-Arabinonate hydro-lyase | D-Arabinonate <=> 2-Dehydro-3-deoxy-D-xylonate + H2O |  | 4.2.1.5
0.0005 | 0 | 0.001 | R03027 | (3R)-3-Hydroxybutanoyl-CoA hydro-lyase | ([NAME] <=> Crotonoyl-CoA + H2O | Butanoate metabolism | 4.2.1.55
0.0005 | 0 | 0.001 | R02990 | [NAME] CoA-transferase | Succinyl-CoA + 3-Oxoadipate <=> Succinate + 3-Oxoadipyl-CoA | Benzoate degradation via hydroxylation | 2.8.3.6
0.0005 | 0 | 0.001 | R02989 | 3-oxoadipate:NADP+ oxidoreductase | 3-Oxoadipate + NADP+ <=> 2-Maleylacetate + NADPH + H+ | Benzoate degradation via hydroxylation | 1.3.1.32
0.0005 | 0 | 0.001 | [NAME] | D-Arginine:2-oxoglutarate aminotransferase | D-Arginine + 2-Oxo acid <=> 5-Guanidino-2-oxopentanoate + D-Amino acid | D-Arginine and D-ornithine metabolism | 2.6.1.21
0.0005 | 0 | 0.001 | R02923 | D-Arginine:oxygen oxidoreductase (deaminating) | D-Arginine + H2O + Oxygen <=> 5-Guanidino-2-oxopentanoate + NH3 + H2O2 | D-Arginine and D-ornithine metabolism | 1.4.3.3
0.0005 | 0 | 0.001 | R02758 | ATP:acylglycerol 3-phosphotransferase | ATP + 2-Acylglycerol <=> ADP + 2-Acyl-sn-glycerol 3-phosphate |  | 2.7.1.94
0.0005 | 0 | 0.001 | R02727 | alpha,alpha-Trehalose:orthophosphate beta-D-glucosyltransferase | alpha,alpha-Trehalose + Orthophosphate <=> D-Glucose + beta-D-Glucose 1-phosphate | Starch and sucrose metabolism | 2.4.1.64
0.0005 | 0 | 0.001 | R02714 | D-Arabinono-1,4-lactone lactonohydrolase | D-Arabinono-1,4-lactone + H2O <=> D-Arabinonate |  | 3.1.1.30
0.0005 | 0 | 0.001 | R02697 | 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase | 4-Hydroxyphenylacetaldehyde + NADP+ + H2O <=> 4-Hydroxyphenylacetate + NADPH + H+ | Tyrosine metabolism | 1.2.1.5
0.0005 | 0 | 0.001 | R02695 | 4-Hydroxyphenylacetaldehyde:NAD+ oxidoreductase | 4-Hydroxyphenylacetaldehyde + NAD+ + H2O <=> 4-Hydroxyphenylacetate + NADH + H+ | Tyrosine metabolism | 1.2.1.5         1.2.1.29        1.2.1.53
0.0005 | 0 | 0.001 | R02461 | D-Ornithine 4,5-aminomutase | D-Ornithine <=> (2R,4S)-2,4-Diaminopentanoate | D-Arginine and D-ornithine metabolism | 5.4.3.5
0.0005 | 0 | 0.001 | R02339 |  | Indole + Oxygen <=> Indoxyl + H2O | Tryptophan metabolism | 1.14.16.-
0.0005 | 0 | 0.001 | R02277 | Secondary-alcohol:oxygen oxidoreductase | Secondary alcohol + Oxygen <=> Ketone + H2O2 |  | 1.1.3.18
0.0005 | 0 | 0.001 | R02257 | Propane-1,2-diol:NAD+ oxidoreductase | Propane-1,2-diol + NAD+ <=> (S)-Lactaldehyde + NADH | Pyruvate metabolism | 1.1.1.77
0.0005 | 0 | 0.001 | R01976 | (S)-3-Hydroxybutanoyl-CoA:NADP+ oxidoreductase | (S)-3-Hydroxybutanoyl-CoA + NADP+ <=> Acetoacetyl-CoA + NADPH + H+ | Butanoate metabolism | 1.1.1.157
0.0005 | 0 | 0.001 | R01782 | 2-Dehydro-3-deoxy-D-pentanoate glycoaldehyde-lyase | 2-Dehydro-3-deoxy-D-xylonate <=> Pyruvate + Glycolaldehyde | Pentose and glucuronate interconversions | 4.1.2.28
0.0005 | 0 | 0.001 | R01678 | Lactose galactohydrolase | Lactose + H2O <=> alpha-D-Glucose + D-Galactose | Galactose metabolism | 3.2.1.23        3.2.1.108
0.0005 | 0 | 0.001 | R01632 | Protocatechuate:oxygen 4,5-oxidoreductase (decyclizing) | 3,4-Dihydroxybenzoate + Oxygen <=> 4-Carboxy-2-hydroxymuconate semialdehyde | Benzoate degradation via hydroxylation,2,4-Dichlorobenzoate degradation | 1.13.11.8
0.0005 | 0 | 0.001 | R01574 | D-Arabinose:NAD+ 1-oxidoreductase | D-Arabinose + NAD+ <=> D-Arabinono-1,4-lactone + NADH + H+ |  | 1.1.1.116       1.1.1.117
0.0005 | 0 | 0.001 | R01371 | Phenyllactate:NADP+ oxidoreductase | Phenyllactate + NADP+ <=> Phenylpyruvate + NADPH | Phenylalanine metabolism | 1.1.1.222       1.1.1.237
0.0005 | 0 | 0.001 | R01370 | Phenyllactate:NAD+ oxidoreductase | Phenyllactate + NAD+ <=> Phenylpyruvate + NADH | Phenylalanine metabolism | 1.1.1.222       1.1.1.237
0.0005 | 0 | 0.001 | R01352 | Glycerol-ester acylhydrolase | 2-Acylglycerol + H2O <=> Glycerol + Fatty acid |  | 3.1.1.23
0.0005 | 0 | 0.001 | R01299 | 4-hydroxybenzoate,NADPH:oxygen oxidoreductase (1-hydroxylating, decarboxylating) | 4-Hydroxybenzoate + Oxygen + NADPH + H+ <=> p-Benzenediol + CO2 + NADP+ + H2O |  | 1.14.13.64
0.0005 | 0 | 0.001 | R01297 | 4-hydroxybenzoate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating) | 4-Hydroxybenzoate + Oxygen + NADH + H+ <=> p-Benzenediol + CO2 + NAD+ + H2O |  | 1.14.13.64
0.0005 | 0 | 0.001 | R01115 | CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) | CMP-N-acetylneuraminate + 2 Ferrocytochrome [NAME] Oxygen + 2 H+ <=> CMP-N-glycoloylneuraminate + 2 Ferricytochrome b5 + H2O | Aminosugars metabolism | 1.14.18.2
0.0005 | 0 | 0.001 | R01026 | Acetylcholine aectylhydrolase | Acetylcholine + H2O <=> Choline + Acetate | Glycerophospholipid metabolism | 3.1.1.7
0.0005 | 0 | 0.001 | R01023 | Acetyl-CoA:choline O-acetyltransferase | Acetyl-CoA + Choline <=> CoA + Acetylcholine | Glycerophospholipid metabolism | 2.3.1.6
0.0005 | 0 | 0.001 | R00983 | 2,3-Dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) | 2,3-Dihydroxyindole + Oxygen <=> Anthranilate + CO2 | Tryptophan metabolism | 1.13.11.23
0.0005 | 0 | 0.001 | R00856 | CTP:sn-glycerol-3-phosphate cytidylyltransferase | CTP + sn-Glycerol 3-phosphate <=> Pyrophosphate + CDP-glycerol | Glycerophospholipid metabolism | 2.7.7.39
0.0005 | 0 | 0.001 | R00855 | CDPglycerol phosphoglycerohydrolase | CDP-glycerol + H2O <=> CMP + sn-Glycerol 3-phosphate | Glycerophospholipid metabolism | 3.6.1.16
0.0005 | 0 | 0.001 | R00829 | Succinyl-CoA:acetyl-CoA C-acyltransferase | Succinyl-CoA + Acetyl-CoA <=> CoA + 3-Oxoadipyl-CoA | Benzoate degradation via hydroxylation | 2.3.1.16        2.3.1.174
0.0005 | 0 | 0.001 | R00819 | Benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating) | Benzoate + Oxygen + NADH <=> Catechol + CO2 + NAD+ |  | 1.14.12.10
0.0005 | 0 | 0.001 | R00645 |  | Ascorbate <=> Monodehydroascorbate + H+ | Ascorbate and aldarate metabolism | 1.14.-.-
0.0005 | 0 | 0.001 | R00624 | Secondary_alcohol:NAD+ oxidoreductase | Secondary alcohol + NAD+ <=> Ketone + NADH + H+ |  | 1.1.1.1
0.0005 | 0 | 0.001 | [NAME] | 2-Oxoglutarate:Thiamin diphosphate 2-oxidoreductase(decarboxylating and acceptor-succinylating) | 2-Oxoglutarate + Thiamin diphosphate <=> 3-Carboxy-1-hydroxypropyl-ThPP + CO2 | Citrate cycle (TCA cycle) | 1.2.4.2
0.0005 | 0 | 0.001 | R00556 |  | L-Arginine + Oxygen + H2O <=> 2-Oxoarginine + H2O2 + NH3 | Arginine and proline metabolism | 1.4.3.-
0.0005 | 0 | 0.001 | R00521 | Formyl-CoA hydrolase | Formyl-CoA + H2O <=> CoA + Formate | Glyoxylate and dicarboxylate metabolism | 3.1.2.10
0.0005 | 0 | 0.001 | R00399 |  | L-Alanine + Acetyl-CoA <=> 2-Amino-4-oxopentanoic acid + CoA | D-Arginine and D-ornithine metabolism | 2.3.1.-
0.0005 | 0 | 0.001 | R00393 | Acyl-CoA:acetate CoA-transferase | Acyl-CoA + Acetate <=> Fatty acid anion + Acetyl-CoA |  | 2.8.3.8
0.0005 | 0 | 0.001 | R00383 | Acyl-CoA hydrolase | Acyl-CoA + H2O <=> CoA + Carboxylate |  | 3.1.2.18        3.1.2.19        3.1.2.20
0.0005 | 0 | 0.001 | R00306 | 1,4-beta-D-Glucan glucohydrolase | Cellobiose + H2O <=> 2 D-Glucose | Starch and sucrose metabolism | 3.2.1.74
0.0005 | 0 | 0.001 | R00197 | (R)-Lactate:ferricytochrome-c 2-oxidoreductase | (R)-Lactate + 2 Ferricytochrome c <=> Pyruvate + 2 Ferrocytochrome c | Pyruvate metabolism | 1.1.2.4
0.0005 | 0 | 0.001 | R00160 | FAD nucleotidohydrolase | FAD + H2O <=> AMP + FMN | [NAME] metabolism | 3.6.1.9         3.6.1.18
0.0005 | 0 | 0.001 | R00068 | L-Ascorbate:oxygen oxidoreductase | Oxygen + 2 Ascorbate <=> 2 L-Dehydroascorbate + 2 H2O | Ascorbate and aldarate metabolism | 1.10.3.3
0.0005 | 0 | 0.001 | R00024 | D-Ribulose 1,5-bisphosphate carboxy-lyase (dimerizing) | D-Ribulose 1,5-bisphosphate + CO2 + H2O <=> 2 3-Phospho-D-glycerate | Carbon fixation | 4.1.1.39
0.0005 | 0 | 0.001 | R00007 | 4-Hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase | 4-Hydroxy-4-methyl-2-oxoglutarate <=> 2 Pyruvate | Benzoate degradation via hydroxylation | 4.1.3.17
0.0005 | 0 | 0.001 | EC035 | fatty acid oxidation (Butanoyl-CoA ) | [c]btcoa + fad + h2o + nad --> aacoa + fadh2 + h + nadh | Alternate Carbon Metabolism