Spreadsheet: 15111c6c-dada-4a06-8768-70ef5fa8474b
Sheet: Sheet1

PRIME KEY | RECIPIENT | OTHER NAME | ZIP CODE | AWARD AMOUNT | EXPENDITURE | [NAME] OF WORK | JOB [NAME] | FTE JOB IMPACT
 | KEY | Prime recipient | Prime vendor | Subrecipient | Subrecipient vendor | prime recipient with no sub-awards
20093007431505ARC 0755725G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 991956 | 44243 | A three-year interdisciplinary research program will be undertaken at Cape Espenberg, located on the northern coast of the Seward Peninsula (Alaska), with a focus on the history of human settlement and response to climate change between AD 800 and 1400. D | Investigator, Post Doctorate, Graduate Student, Research Assistant | 19
20093007431505ARC 0755725G | UNIVERSITY OF ALASKA FAIRBANKS | UNIVERSITY OF ALASKA FAIRBANKS | 997757880 | 508138 | 8912.01
20093007431505ARC 0755725G | UNIVERSITY OF CALIFORNIA, DAVIS | DAVIS CAMPUS/NEWS SERVICE | 956168522 | 145623 | 0
20093007431505ATM 0936058G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 77451 | 40198 | This project aims to make the first airborne observations of polar mesospheric clouds. A campaign is proposed from approximately 25 June to 21 July, coinciding with the period when the occurrence frequency of polar mesospheric clouds is expected to peak. |  | 0
20093007431505ATM 0936058G | Aerospatial Systems LLC |  | 803025672 |  | 25742.25 | Field Flight Campaign
200930410963141S01RR025681-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 85925 | 85925 | The proposed project is to obtain equipment that utilizes the most modern technological advances inorder to update our laser capture microdissection (LCM) equipment. LCM is a technology for isolating pure populations of cells from tissue sections. Cells c |  | 0
200930410963141S01RR025681-01G | MDS Analytical Technologies (US) Inc |  | 940891136 |  | 85925 | Test and measurement equipment
20093187406538H391A090020G | EDUCATION, COLORADO BOARD OF |  | 802031799 | 148730571 | 4091882 | Grants to States for the Education of Children with Disabilities | Special education teachers, speech pathologists, personal care paraprofessionals, social workers, psychologists. | 166
20093187406538H391A090020G | ADAMS 12 FIVE STAR SCHOOLS |  | 802412601 | 7253765 | 0
20093187406538H391A090020G | ADAMS COUNTY SCHOOL DISTRICT #1 | MAPLETON SCHOOL DISTRICT | 802295806 | 1116443 | 0
20093187406538H391A090020G | ADAMS COUNTY SCHOOL DISTRICT #50 |  | 800305898 | 1946184 | 0
20093187406538H391A090020G | ADAMS COUNTY SCHOOL DISTRICT 14 CAPITAL FACILITY FEE FOUNDAT |  | 800223203 | 1432942 | 0
20093187406538H391A090020G | ARAPAHOE COUNTY SCHOOL DISTRICT 6 |  | 801202012 | 2653930 | 297149
20093187406538H391A090020G | BOULDER VALLEY SCHOOL DISTRICT RE-2 |  | 803019011 | 5125449 | 825038
20093187406538H391A090020G | DOUGLAS COUNTY SCHOOL DISTRICT |  | 801041739 | 9367575 | 1540074
20093187406538H391A090020G | FALCON SCHOOL DISTRICT 49 (INC) |  | 808318127 | 2187251 | 503220
20093187406538H391A090020G | HARRISON SCHOOL DISTRICT 2 |  | 809063543 | 2166466 | 27315
20093187406538H391A090020G | NORTHEAST COLORADO BOARD OF COOPERATIVE EDUCATIONAL SERVICES | NORTHEAST COLORADO BOCES | 807310098 | 799055 | 30229
20093187406538H391A090020G | POUDRE SCHOOL DISTRICT |  | 805212211 | 4477158 | 156050
20093187406538H391A090020G | SCHOOL DISTRICT 27J (INC) |  | 806013257 | 2382153 | 389661
20093187406538H391A090020G | SCHOOL DISTRICT FREMONT RE 1 |  | 812123564 | 684444 | 249890
20093187406538H391A090020G | Ute Pass Special Boces |  | 808663160 | 796370 | 73256
20093187406538H391A090020G | Rigby Products |  | 606930000 |  | 0
20093187406538H391A090020G | Spectrum K-12 |  | 212042600 |  | 0
20093187406538H391A090020G | The Children's Hospital |  | 800450000 |  | 0
20093187406538H392A090097G | EDUCATION, COLORADO BOARD OF |  | 802031799 | 5281455 | 0 | Assist States to make available special education and related services for children with disabilities age 3 through 5 years, and at a State's discretion, to 2 year old children with disabilities who will reach age three during the school year. |  | none
20093187406538H392A090097G | ADAMS 12 FIVE STAR SCHOOLS |  | 802412601 | 257867 | 0
20093187406538H392A090097G | ADAMS COUNTY SCHOOL DISTRICT #1 | MAPLETON SCHOOL DISTRICT | 802295806 | 39682 | 0
20093187406538H392A090097G | ADAMS COUNTY SCHOOL DISTRICT #50 |  | 800305898 | 69174 | 0
20093187406538H392A090097G | ADAMS COUNTY SCHOOL DISTRICT 14 CAPITAL FACILITY FEE FOUNDAT |  | 800223203 | 50915 | 0
20093187406538H392A090097G | SCHOOL DISTRICT 27J (INC) | BRIGHTON SCHOOL DISTRICT 27J | 806018519 | 84672 | 0
20093187406538S386A090006G | EDUCATION, COLORADO BOARD OF |  | 802031704 | 7032633 | 0 | Educational Technology State Grants to States to improve student academic achievement through the innovative use and the effective integration of new and emerging technology with teacher training, curriculum development, and successful research-based instructional methods.
20093187406538S386A090006G | ADAMS 12 FIVE STAR SCHOOLS |  | 802412601 | 111938 | 0
20093187406538S386A090006G | ADAMS 12 FIVE STAR SCHOOLS |  | 802412601 | 185805 | 0
20093187406538S386A090006G | ADAMS COUNTY SCHOOL DISTRICT #1 | MAPLETON SCHOOL DISTRICT | 802295806 | 24606 | 0
20093187406538S386A090006G | ADAMS COUNTY SCHOOL DISTRICT #50 |  | 800305898 | 79743 | 0
20093187406538S386A090006G | ADAMS COUNTY SCHOOL DISTRICT 14 CAPITAL FACILITY FEE FOUNDAT |  | 800223203 | 150000 | 0
20093187406538S386A090006G | ADAMS COUNTY SCHOOL DISTRICT 14 CAPITAL FACILITY FEE FOUNDAT |  | 800223203 | 53389 | 0
20093187406538S389A090006G | EDUCATION, COLORADO BOARD OF |  | 802031799 | 111135922 | 278962 | Title I, Part A--Improving Basic Programs Operated by Local Educational Agencies. | Reading interventionist and teacher retained | 2
20093187406538S389A090006G | ADAMS 12 FIVE STAR SCHOOLS |  | 802412601 | 3917680 | 0
20093187406538S389A090006G | ADAMS COUNTY SCHOOL DISTRICT #1 | MAPLETON SCHOOL DISTRICT | 802295806 | 701826 | 0
20093187406538S389A090006G | ADAMS COUNTY SCHOOL DISTRICT #50 |  | 800305898 | 2516600 | 0
20093187406538S389A090006G | ADAMS COUNTY SCHOOL DISTRICT 14 CAPITAL FACILITY FEE FOUNDAT |  | 800223203 | 1586786 | 0
20093187406538S389A090006G | ALAMOSA SCHOOL DISTRICT RE 11 J | ALAMOSA HIGH SCHOOL | 811014204 | 582371 | 0
20093187406538S389A090006G | BENNETT SCHOOL DISTRICT 29 J |  | 801028015 | 49553 | 0
20093187406538S389A090006G | Delta County Joint School District No.50 | Delta Mntrose Tchnical College | 814169364 | 449242 | 18387
20093187406538S389A090006G | ENGLEWOOD SCHOOL DISTRICT #1 | ARAPAHOE COUNTY SCHOOL DISTRICT #1 | 801104600 | 558697 | 0
20093187406538S389A090006G | HOEHNE REORGANIZED SCHOOL DIST 3 |  | 810820091 | 17775 | 13066
20093187406538S389A090006G | Huerfano School District | La Veta Elementary School | 810550085 | 20380 | 8667
20093187406538S389A090006G | IGNACIO JOINT SCHOOL DIST 11 |  | 811370460 | 94795 | 20000
20093187406538S389A090006G | LAMAR SCHOOL DISTRICT RE-2 |  | 810523163 | 360532 | 158006
20093187406538S389A090006G | SANGRE DE CRISTO DIST RE-22J | SANGRE DE CRISTO JR SR H S | 811460145 | 107134 | 0
20093187406538S389A090006G | SCHOOL DISTRICT 27J (INC) | BRIGHTON SCHOOL DISTRICT 27J | 806018519 | 475042 | 0
20093187406538S389A090006G | SHERIDAN SCHOOL DISTRICT 2 |  | 802363105 | 696328 | 0
20093187406538S389A090006G | STRASBURG SCHOOL DISTRICT |  | 801360207 | 50092 | 0
20093187406538S389A090006G | WELD COUNTY SCHOOL DISTRICT RE-8 | FORT LUPTON SCHOOLS | 806211329 | 234840 | 60836
20093187406538S389A090006G | CompassLearning |  | 303842099 |  | 0
20093187406538S389A090006G | Dale Furnish & Asooc |  | 992140988 |  | 0
20093187406538S389A090006G | MCPC, Inc |  | 152643283 |  | 0
20093187406538S389A090006G | Micro One |  | 430260848 |  | 0
20093188589402S394A090006G | EXECUTIVE OFFICE OF THE STATE OF COLORADO | GOVERNOR'S OFFICE | 802031941 | 416658526 | 232325921.78 | State Fiscal Stabalization Fund-Education Grants | As stipulated by the U.S. Department of Education, State Fiscal Stabilization Funds were primarily utilized to provide support for salaries and benefits related to the classroom and laboratory instruction, student services and administrative support within the Colorado public university system. As such, the majority of the positions covered related to the Professorial job series as well as Graduate Teaching Assistants. Other positions supported included accountants, administrative assistants, general professionals, IT support staff, as well as college and central level administrators. | 2673.1
20093188589402S394A090006G | School District 1 In The City and County of Denver and State of Colorado | Emily Griffith Oprtnty Schl | 802042114 | 3337290 | 1668645.03
20093188589402S394A090006G | AIMS COLLEGE |  | 806320069 | 3789384 | 3789384
20093188589402S394A090006G | COLORADO MOUNTAIN COLLEGE | COLORADO MOUNTAIN JUNIOR COLLEGE DISTRICT | 816013403 | 2787262 | 2087407.57
20093188589402S394A090006G | Delta County Joint School District 50 | Delta Montrose Area Vocational | 814167965 | 637576 | 486194.82
20093188589402S394A090006G | EXECUTIVE OFFICE OF THE STATE OF COLORADO | GOVERNOR'S OFFICE | 813289196 | 353040 | 353040
20093188589402S394A090006G | AIMS COLLEGE |  | 800119307 | 713092 | 587885.93
20093188589402S394A090006G | Rocky Mountain Chapter, IEC, Inc. |  | 802296215 |  | 0
20093188589402S397A090006G | EXECUTIVE OFFICE OF THE STATE OF COLORADO | GOVERNOR'S OFFICE | 802031776 | 138364142 | 37321569.45 | State Fiscal Stabilization Fund - Government Services | The Recovery Act State Fiscal Stabilization Fund - Government Service Fund funded correctional jobs within the Department of Corrections (DOC) are responsible for supervising and managing violent and non-violent offenders. Security and Housing personnel are responsible for monitoring, inspecting, searching, directing, transporting and restraining offenders; maintaining equipment, keeping inventories of keys, tools, and weapons; and conducting physical searches of persons and facilities to control contraband. | 524.27
20093188589402S397A090006G | UNIVERSITY OF DENVER |  | 800269403 | 169627 | 169627
20093188589402S397A090006G | EXECUTIVE OFFICE OF THE STATE OF COLORADO | GOVERNOR'S OFFICE | 802211099 | 118373 | 118373
2009380848980609RCHCO002G | GOVENOR'S COMMISSION ON COMMUNITY SERVICE |  | 802031762 | 832831 | 194430 | The purpose of the grant is to recruit, train, monitor and evaluate Americorps members to serve in a variety of programs including mentoring, early childhood, conservation, drug prevention and awareness. | none | 0
2009380848980609RCHCO002G | YEAR ONE, INC | [NAME] HIGH YOUTH CORPS | 802041724 | 832831 | 194430
2009380848980609RFHCO001G | GOVENOR'S COMMISSION ON COMMUNITY SERVICE |  | 802031762 | 1346904 | 17029.35 | ARRA AmeriCorps members will receive training and development by installing energy efficient measures into 350 low-income housing units. They will be active in local communities and engage 250 community members in meaningful service projects. \n\n\n\n
2009380848980609RFHCO001G | PARTNERS IN ROUTT COUNTY | PARTNERS IN ROUTT CO | 804774325 | 78600 | 0
2009380848980609RFHCO001G | SAGUACHE UNITED METHODIST CHURCH |  | 811250626 | 2550 | 0
2009380848980609RFHCO001G | DENVER, CITY & COUNTY OF | HUMAN SERVICES DEPT | 802043221 | 175231 | 0
2009380848980609RFHCO001G | WELD, COUNTY OF |  | 806319117 |  | 0
2009380848980609RFHCO001G | COLORADO YOUTH CORPS ASSOCIATION |  | 802031691 |  | 4649
20093848565532DE-EE0000079G | NATURAL RESOURCES, COLORADO DEPARTMENT OF | GOVERNOR'S ENERGY OFFICE | 802031940 | 79531213 | 5440892.55 | RECOVERY ACT - WEATHERIZATION ASSISTANCE FOR LOW INCOME PERSONS IN THE STATE OF COLORADO | 9.01 JOBS CREATED AT PRIMARY RECIPIENT LEVEL INCLUDING ADMINISTRATIVE, TRAINING, TECHNICAL ASSISTANCE AND QUALITY ASSURANCE POSITIONS.  112.37 JOBS CREATED AT SUBRECIPIENT LEVEL INCLUDING ADMINISTRATIVE, MANAGERIAL, AND WEATHERIZATION FIELD STAFF POSISTIONS.  FIELD STAFF INCLUDES ENERGY AUDITORS, WEATHERIZATION WORKERS, INSPECTORS, FIELD SUPERVISORS, AND HVAC TECHNICIANS. | 121.38
20093848565532DE-EE0000079G | US OFFICE OF PERSONNEL MGMT CL |  | 800140000 |  | 49647 | CUSTOMER WORKSHOPS
20093848565532DE-EE0000079G | HOUSING AUTHORITY OF BOULDER COUNTY | BOULDER COUNTY HOUSING AUTHORITY | 803044104 | 2232202 | 782615.29
20093848565532DE-EE0000079G | ARAPAHOE, COUNTY OF DONE | ARAPAHOE COUNTY GOVERNMENT | 800117816 | 2924575 | 937839.29
20093848565532DE-EE0000079G | SUN POWER, INC. |  | 802052314 | 1490907 | 352110.42
20093848565532DE-EE0000079G | ENERGY RESOURCE CENTER |  | 809152812 | 2049150 | 818979.37
20093848565532DE-EE0000079G | PUEBLO COUNTY GOVERNMENT | HOUSING & HUMAN SERVICES | 810014200 | 2045495 | 479854.57
20093848565532DE-EE0000079G | HOUSING RESOURCES OF WESTERN COLORADO | ENERGY OFFICE, THE | 815044437 | 1271919 | 369574.9
20093848565532DE-EE0000079G | NORTHWEST COLORADO COUNCIL OF GOVERNMENTS |  | 804982308 | 1575527 | 635719.1
20093848565532DE-EE0000079G | NORTH EASTERN COLORADO ASSOCIATION OF LOCAL GOVERNMENTS |  | 807012148 | 1533960 | 462952.91
20093848565532DE-EE0000079G | VETERANS GREEN-JOBS ALLIANCE |  | 802021162 | 652893 | 172530.6
20093848565532DE-EE0000079G | FOUR CORNERS OFFICE FOR RESOURCE EFFICIENCY |  | 813015474 | 547561 | 145080.2
20093848565532DE-EE0000079G | [NAME] |  | 809060000 |  | 0
20093848565532DE-EE0000079G | Lakewood Fordland |  | 802150000 |  | 0
20093848565532DE-EE0000079G | Phi Long Ford |  | 809200000 |  | 0
20093848565532DE-EE0000079G | Rush Enterpises |  | 802160000 |  | 0
20093848565532DE-EE0000079G | Sill-Terhar Motors Inc. |  | 800201678 |  | 0
20093878137389USDA-FSA-ARRA-AGP-5G | AGRICULTURE, COLORADO DEPARTMENT OF |  | 802158000 | 46421 | 53972.92 | 2008 Aquaculture Grant Program which provides assistance to eligible aquaculture producers
20093878137389USDA-FSA-ARRA-AGP-5G | COLORADO CATCH LLC |  | 811510210 |  | 32974.18 | DISTRIBUTIONS TO NONGOV/ORGAN
2009387814760209AACOC1RRG | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 802031702 | 847851 | 303089.8 | Congregate Meals - ARRA this is for the Elderly population 60 years and over including the at-risk population.  These meals are provided at a congregate nutrition site throughout the State of Colorado. | none | 0
2009387814760209AACOC1RRG | NORTH EASTERN COLORADO ASSOCIATION OF LOCAL GOVERNMENTS |  | 807012148 | 21907 | 12209
2009387814760209AACOC1RRG | PIKES PEAK AREA COUNCIL OF GOVERNMENTS | PIKES PEAK AREA AGENCY ON AGING | 809051501 | 93973 | 65872
2009387814760209AACOC1RRG | East Central Council of Governments | Eccog | 802030028 | 11351 | 10117
2009387814760209AACOC1RRG | CORPORATION FOR NATIONAL & COMMUNITY SERVICE | SENIOR CORPS | 810500494 | 19296 | 5759
2009387814760209AACOC1RRG | PUEBLO COUNTY GOVERNMENT | HOUSING & HUMAN SERVICES | 810014200 | 42493 | 11999
2009387814760209AACOC1RRG | South Central Colorado Seniors Inc | Area On Aging | 811012409 | 20874 | 9417
2009387814760209AACOC1RRG | San Juan Basin Area Agency On Aging | Area Agency On Aging | 813212748 | 28112 | 11084
2009387814760209AACOC1RRG | Region 10 League of Economics Assistance and Planning Inc | Region 10 | 814020849 | 32355 | 32355
2009387814760209AACOC1RRG | COUNTY OF MESA |  | 815025035 | 46540 | 9307
2009387814760209AACOC1RRG | NORTHWEST COLORADO COUNCIL OF GOVERNMENTS |  | 804982308 | 16458 | 0
2009387814760209AACOC1RRG | UPPER ARKANSAS AREA COUNCIL OF GOVERNMENTS |  | 812150510 | 21386 | 0
2009387814760209AACOC1RRG | HUERFANO-LAS ANIMAS AREA COUNCIL OF GOVERNMENTS | SOUTH CENTRAL COUNCIL OF GOVERNMENTS | 810822047 | 11772 | 7018
2009387814760209AACOC1RRG | County of Larimer | Office On Aging | 805242004 | 42686 | 22736
2009387814760209AACOC1RRG | WELD, COUNTY OF |  | 806321805 | 39502 | 21392.8
2009387814760209AACOC1RRG | Denver Regional Council of Governments | Drcog | 803025606 | 360305 | 72844
2009387814760209AACOC1RRG | BOULDER, COUNTY OF | BOULDER COUNTY | 803061824 | 38841 | 10980
2009387814760209AACOC1RRG | Housing Authority 2009 |  | 809051501 |  | 0
2009387814760209AACOC1RRG | Senior Nutrition Meal Provider |  | 803025606 |  | 0
2009387814760209AACOC1RRG | SRDA |  | 810014200 |  | 0
2009387814760209AACOC1RRG | University of Northern Colorado |  | 806321805 |  | 0
2009387814760209AACOC1RRG | Volunteers of America |  | 805242004 |  | 0
2009387814760209AACOC1RRG | Volunteers of America |  | 814020849 |  | 0
2009387814760209AACOC2RRG | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 802031702 | 417403 | 262009 | Home-Delivered Meals - ARRA - this is for the Elderly population 60 years and over including the at-risk population.  These home delivered meals will be distributed throughout the State of Colorado.
2009387814760209AACOC2RRG | NORTH EASTERN COLORADO ASSOCIATION OF LOCAL GOVERNMENTS |  | 807012148 | 10784 | 8615
2009387814760209AACOC2RRG | PIKES PEAK AREA COUNCIL OF GOVERNMENTS | PIKES PEAK AREA AGENCY ON AGING | 809051501 | 46263 | 4930
2009387814760209AACOC2RRG | East Central Council of Governments | Eccog | 808360028 | 5588 | 5104
2009387814760209AACOC2RRG | CORPORATION FOR NATIONAL & COMMUNITY SERVICE | SENIOR CORPS | 810500494 | 9500 | 3839
2009387814760209AACOC2RRG | PUEBLO COUNTY GOVERNMENT | HOUSING & HUMAN SERVICES | 810014200 | 20920 | 10836
2009387814760209AACOC2RRG | South Central Colorado Seniors Inc | Area On Aging | 811012409 | 10277 | 10277
2009387814760209AACOC2RRG | San Juan Basin Area Agency On Aging | Area Agency On Aging | 813212748 | 13840 | 10026
2009387814760209AACOC2RRG | Region 10 League of Economics Assistance and Planning Inc | Region 10 | 814020849 | 15929 | 15929
2009387814760209AACOC2RRG | COUNTY OF MESA |  | 815025035 | 22912 | 4584
2009387814760209AACOC2RRG | NORTHWEST COLORADO COUNCIL OF GOVERNMENTS |  | 804982308 | 8102 | 0
2009387814760209AACOC2RRG | UPPER ARKANSAS AREA COUNCIL OF GOVERNMENTS |  | 812150510 | 10528 | 0
2009387814760209AACOC2RRG | HUERFANO-LAS ANIMAS AREA COUNCIL OF GOVERNMENTS | SOUTH CENTRAL COUNCIL OF GOVERNMENTS | 810822047 | 5796 | 5794
2009387814760209AACOC2RRG | County of Larimer | Office On Aging | 805242004 | 21014 | 6284
2009387814760209AACOC2RRG | WELD, COUNTY OF |  | 806321805 | 19447 | 8288
2009387814760209AACOC2RRG | Denver Regional Council of Governments | Drcog | 803025606 | 177381 | 164390
2009387814760209AACOC2RRG | BOULDER, COUNTY OF | BOULDER COUNTY | 803061824 | 19122 | 3113
2009387814760209AACOC2RRG | El Paso Fountain Valley 2009 |  | 809051501 |  | 0
2009387814760209AACOC2RRG | Park County Senior Coalition 2009 |  | 809051501 |  | 0
2009387814760209AACOC2RRG | Teller Senior Coalition 2009 |  | 809051501 |  | 0
2009387814760209AACOC2RRG | Volunteers of America |  | 803025606 |  | 0
200938781476023C0840011G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 802031714 | 367982 | 363670 | [NAME] ADMIN (O) | Refrigeration Service Technicians | 2
200938781476023C0840011G | ADAMS, COUNTY OF |  | 800224811 | 42861.18 | 42861.18
200938781476023C0840011G | CARE AND SHARE, INC. | CARE AND SHARE FOOD BANK | 809151200 | 30000 | 30000
200938781476023C0840011G | UPPER ARKANSAS AREA COUNCIL OF GOVERNMENTS |  | 812150510 | 43641 | 43641
200938781476023C0840011G | PUEBLO COUNTY GOVERNMENT | HOUSING & HUMAN SERVICES | 810014200 | 41819.6 | 41819.6
200938781476023C0840011G | Colorado Food Bank Association |  | 802392906 | 44965.63 | 44965.63
200938781476023C0840011G | SUPERMARKETS, INC | BEST BRANDS PLUS | 811549990 | 5729.54 | 5729.54
200938781476023C0840011G | La Puente Home Inc | La Puente Home Shelter | 811019998 | 9021.15 | 9021.15
200938781476023C0840011G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 800039998 | 11799.68 | 11799.68
200938781476023C0840011G | FOODSERVICEWAREHOUSE.COM, LLC |  | 810209900 | 4595.36 | 4595.36
200938781476023C0840011G | CARE AND SHARE, INC. | CARE AND SHARE FOOD BANK | 810731602 | 1571.9 | 1571.9
200938781476023C0840011G | FOODSERVICEWAREHOUSE.COM, LLC |  | 810541716 | 4954 | 4954
200938781476023C0840011G | ADAMS, COUNTY OF |  | 807019998 | 19706.87 | 19706.87
200938781476023C0840011G | SEARS, ROEBUCK AND CO. | SEARS | 807512856 | 2089.97 | 2089.97
200938781476023C0840011G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 811529990 | 18946.15 | 18946.15
200938781476023C0840011G | SEARS, ROEBUCK AND CO. | SEARS | 812529990 | 10520.57 | 10520.57
200938781476023C0840011G | Rock Castle Inter-Church Task Force |  | 801049998 | 8725.93 | 8725.93
200938781476023C0840011G | FOOD BANK FOR LARIMER COUNTY |  | 805249997 | 9550 | 9550
200938781476023C0840011G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 816029998 | 6917.48 | 6917.48
200938781476023C0840011G | Mexican American Development Association, Inc | Mada | 814019929 | 774 | 774
200938781476023C0840011G | MONTEZUMA, COUNTY OF | [NAME] | 813219998 | 1312.44 | 1312.44
200938781476023C0840011G | SEARS, ROEBUCK AND CO. | SEARS | 814329997 | 509.48 | 509.48
200938781476023C0840011G | Sullivan's Appliance |  | 807341535 | 1748.31 | 1748.31
200938781476023C0840011G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 810522712 | 399.9 | 399.9
200938781476023C0840011G | FOODSERVICEWAREHOUSE.COM, LLC |  | 807379998 | 1399 | 1399
200938781476023C0840011G | Weld Food Bank |  | 806329998 | 14030.6 | 14030.6
200938781476023C0840011G | County of Yuma |  | 807581612 | 400 | 400
200938781476023C0840011G | Gradys |  | 810014200 |  | 0
200938781476023C0840011G | [NAME], LLC |  | 802393327 |  | 0
200938781476023C0840011G | [NAME], LLC |  | 802393327 |  | 0
200938781476023C0840011G | Penske Truck Leasing |  | 178015821 |  | 0
20093878147602AD-18357-09-60-A-8G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 802031702 | 240140 | 0 | Senior Community Service Employment Program | none | 0
20093878147602AD183570960A8G | SENIORS' RESOURCE CENTER, INC. | MOUNTAIN SERVICES | 802127033 | 127736 | 0
20093878147602AD183570960A8G | SENIORS!, INC. |  | 802225324 | 100363 | 0
20093878147602AD-18357-09-60-A-8G | SENIORS' RESOURCE CENTER, INC. | MOUNTAIN SERVICES | 802127033 | 127736 | 0
20093878147602AD-18357-09-60-A-8G | SENIORS!, INC. |  | 802225324 | 100363 | 0
20093878147602G0901C4115D7G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 802031702 | 24312305 | 10814012.25 | ARRA Supplemental Funding for the Child Care and Development Fund
20093878147602G0901C4115D7G | QUALISTAR COLORADO |  | 802054976 |  | 67983.99 | OTHER PURCHASED SERVICES
20093878147602G0901C4115D7G | ADAMS, COUNTY OF |  | 800224811 | 1176163.92 | 1176163.92
20093878147602G0901C4115D7G | ARAPAHOE, COUNTY OF DONE | ARAPAHOE COUNTY GOVERNMENT | 801600571 | 168338.1 | 168338.1
20093878147602G0901C4115D7G | County of Archuleta | Dept. of Social/Human Services | 811471507 | 28056.35 | 28056.35
20093878147602G0901C4115D7G | BOULDER, COUNTY OF | BOULDER COUNTY | 803060471 | 526237.13 | 526237.13
20093878147602G0901C4115D7G | County of Chaffee | Dept Health and Human Services | 812010249 | 32470.75 | 32470.75
20093878147602G0901C4115D7G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 808100157 | 8016.1 | 8016.1
20093878147602G0901C4115D7G | County of Conejos | [NAME] | 811400078 | 16032.2 | 16032.2
20093878147602G0901C4115D7G | County of Delta | Delta County Hlth & Humn Svcs | 814161766 | 33196.67 | 33196.67
20093878147602G0901C4115D7G | DENVER, CITY & COUNTY OF | HUMAN SERVICES DEPT | 802025328 | 5012411.78 | 5012411.78
20093878147602G0901C4115D7G | DOUGLAS, COUNTY OF |  | 801041208 | 131304.21 | 131304.21
20093878147602G0901C4115D7G | EAGLE, COUNTY OF |  | 816310850 | 66321.02 | 66321.02
20093878147602G0901C4115D7G | ELBERT, COUNTY OF |  | 801170067 | 26472.97 | 26472.97
20093878147602G0901C4115D7G | EL PASO, COUNTY OF |  | 809032208 | 116315.79 | 116315.79
20093878147602G0901C4115D7G | FREMONT, COUNTY OF | DEPARTMENT OF HUMAN SERVICES | 812123390 | 41154.23 | 41154.23
20093878147602G0901C4115D7G | GARFIELD, COUNTY OF |  | 816021069 | 20243.42 | 20243.42
20093878147602G0901C4115D7G | GUNNISON, COUNTY OF |  | 816021069 | 25645.46 | 25645.46
20093878147602G0901C4115D7G | Judiciary Courts of The State of Colorado | Huerfano County District Court | 810892045 | 34256.62 | 34256.62
20093878147602G0901C4115D7G | COUNTY OF JACKSON | CLERK OFFICE | 804800458 | 15770.49 | 15770.49
20093878147602G0901C4115D7G | JEFFERSON, COUNTY OF | [NAME] COUNTY HUMAN SER | 804194560 | 1378276.9 | 1378276.9
20093878147602G0901C4115D7G | [NAME], COUNTY OF |  | 808070396 | 28056.35 | 28056.35
20093878147602G0901C4115D7G | County of Lake | Lake County Health & Humn Svcs | 804610276 | 37277.04 | 37277.04
20093878147602G0901C4115D7G | LA PLATA COUNTY | LA PLATA COUNTY TREASURER | 813015113 | 50665.22 | 50665.22
20093878147602G0901C4115D7G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 805221250 | 400679.01 | 400679.01
20093878147602G0901C4115D7G | County of Lincoln | Clerks Office | 808210007 | 8016.1 | 8016.1
20093878147602G0901C4115D7G | LOGAN, COUNTY OF | LOGAN COUNTY DEPT SOCIAL SVCS | 807514373 | 20040.25 | 20040.25
20093878147602G0901C4115D7G | COUNTY OF MOFFAT |  | 816252732 | 42737.61 | 42737.61
20093878147602G0901C4115D7G | MONTROSE, COUNTY OF | MONTROSE ADMINISTRATION SERVICES | 814021289 | 193632.99 | 193632.99
20093878147602G0901C4115D7G | OURAY, COUNTY OF |  | 814720572 | 12024.15 | 12024.15
20093878147602G0901C4115D7G | PARK, COUNTY OF |  | 804400638 | 8117.69 | 8117.69
20093878147602G0901C4115D7G | PHILLIPS, COUNTY OF |  | 807340267 | 1292.4 | 1292.4
20093878147602G0901C4115D7G | PITKIN, COUNTY OF |  | 816111948 | 6461.99 | 6461.99
20093878147602G0901C4115D7G | County of Prowers | Prowers Cnty Dept Social Svcs | 810522868 | 8016.1 | 8016.1
20093878147602G0901C4115D7G | PUEBLO COUNTY GOVERNMENT | OFFICE OF BUDGET & FINANCE | 810032992 | 265878.12 | 265878.12
20093878147602G0901C4115D7G | RIO BLANCO, COUNTY OF |  | 816410247 | 30844.32 | 30844.32
20093878147602G0901C4115D7G | ROUTT, COUNTY OF | INFORMATION SYSTEMS | 804770907 | 31773.42 | 31773.42
20093878147602G0901C4115D7G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 811490476 | 17193.74 | 17193.74
20093878147602G0901C4115D7G | SAN MIGUEL, COUNTY OF |  | 814351170 | 6461.99 | 6461.99
20093878147602G0901C4115D7G | COUNTY OF SUMMIT |  | 804240289 | 218769.16 | 218769.16
20093878147602G0901C4115D7G | COUNTY OF TELLER | TELLER, COUNTY OF | 808130959 | 146829.83 | 146829.83
20093878147602G0901C4115D7G | Colorado Department of Human Services | Department of Human Services | 807200230 | 8117.69 | 8117.69
20093878147602G0901C4115D7G | WELD, COUNTY OF |  | 806320758 | 153423.35 | 153423.35
20093878147602G0901C4115D7G | County of Yuma |  | 807581800 | 153423.35 | 16235.37
20093878147602G0901C4115D7G | A CHILD'S TREASURE LEARNING CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | A CHILDS VIEW PRESCHOOL LLC |  | 802025328 |  | 0
20093878147602G0901C4115D7G | A CHILDS VIEW PRESCHOOL LLC |  | 804194560 |  | 0
20093878147602G0901C4115D7G | A NEW GENERATION |  | 800224811 |  | 0
20093878147602G0901C4115D7G | A PLUS LEARNING CENTER DBA IMAGINATION PLUS |  | 802025328 |  | 0
20093878147602G0901C4115D7G | ABC CHILD CARE, LLC |  | 802025328 |  | 0
20093878147602G0901C4115D7G | ACADEMIC PLAY LEARNING CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | AGAPE CREATIVE DAY CARE CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | ARMSTRONG CHILD DEVELOPMENT CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | AURARIA EARLY LEARNING CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | BROTHER BEAR CHILDCARE |  | 800224811 |  | 0
20093878147602G0901C4115D7G | BUNDLES OF BABIES II |  | 802025328 |  | 0
20093878147602G0901C4115D7G | BUNDLES OF BABIES II |  | 800224811 |  | 0
20093878147602G0901C4115D7G | [NAME] DEVELOPMENT |  | 802025328 |  | 0
20093878147602G0901C4115D7G | CATHOLIC CHARITIES M REED DAY NURSERY |  | 802025328 |  | 0
20093878147602G0901C4115D7G | CHERRY GROVE PRESCHOOL |  | 802025328 |  | 0
20093878147602G0901C4115D7G | CHILD QUEST LEARNING CENTER |  | 814021289 |  | 0
20093878147602G0901C4115D7G | CHILDREN ARE THE FUTURE INC |  | 802025328 |  | 0
20093878147602G0901C4115D7G | CHILDRENS CHALET INC |  | 802025328 |  | 0
20093878147602G0901C4115D7G | CHILDRENS HAVEN CHILD CARE CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | CLAYTON FAMILY FUTURES |  | 802025328 |  | 0
20093878147602G0901C4115D7G | CRAYON ACADEMY LEARNING CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | [NAME], INC. |  | 802025328 |  | 0
20093878147602G0901C4115D7G | CRESTMOOR LEARNING CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | DADDY MOM DAYCARE |  | 802025328 |  | 0
20093878147602G0901C4115D7G | DAY ONE DAY CARE LEARNING CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | DENVER CHILD CARE CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | DISCOVERY LAND CHILDCARE CENTER |  | 804194560 |  | 0
20093878147602G0901C4115D7G | DOTTIES DAY CARE AND PRESCHOOL INC |  | 800224811 |  | 0
20093878147602G0901C4115D7G | E AND R CANNON CHILD CARE CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | EARLY EXCELLENCE PROGRAM |  | 802025328 |  | 0
20093878147602G0901C4115D7G | EARLY LEARNING CENTER |  | 803060471 |  | 0
20093878147602G0901C4115D7G | EARLY SUCCESS ACADEMY |  | 802025328 |  | 0
20093878147602G0901C4115D7G | EDNA OLIVER CHILD DEVELOPMENT CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | EL MUNDO FELIZ, INC. |  | 802025328 |  | 0
20093878147602G0901C4115D7G | ENRIQUEZ SANCHEZ LAURA |  | 804240289 |  | 0
20093878147602G0901C4115D7G | FAMILY STAR |  | 802025328 |  | 0
20093878147602G0901C4115D7G | FAMILY STAR |  | 802025328 |  | 0
20093878147602G0901C4115D7G | FLORENCE CRITTENTON PARENT PATHWAYS, INC |  | 802025328 |  | 0
20093878147602G0901C4115D7G | GARCIA LAURA Q |  | 804240289 |  | 0
20093878147602G0901C4115D7G | GREENLEE METRO EXTENDED DAY |  | 802025328 |  | 0
20093878147602G0901C4115D7G | HOPE'S LEARNING CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | JUST FOR KIDS CHILDCARE |  | 808130959 |  | 0
20093878147602G0901C4115D7G | KIDS IN ACTION |  | 804194560 |  | 0
20093878147602G0901C4115D7G | KIDZ, INK |  | 802025328 |  | 0
20093878147602G0901C4115D7G | KIDZ, INK |  | 804194560 |  | 0
20093878147602G0901C4115D7G | KINDER CARE LEARNING CENTER  #355 |  | 802025328 |  | 0
20093878147602G0901C4115D7G | KINDER CARE LEARNING CENTER  764 |  | 804194560 |  | 0
20093878147602G0901C4115D7G | KINDER CARE LEARNING CENTER INC |  | 804194560 |  | 0
20093878147602G0901C4115D7G | [NAME] |  | 802025328 |  | 0
20093878147602G0901C4115D7G | KINDERCARE LEARNING CENTER |  | 803060471 |  | 0
20093878147602G0901C4115D7G | KINDERCARE LEARNING CENTER |  | 800224811 |  | 0
20093878147602G0901C4115D7G | KINDERCARE LEARNING CENTER |  | 804194560 |  | 0
20093878147602G0901C4115D7G | KINDERCARE LEARNING CENTER |  | 804194560 |  | 0
20093878147602G0901C4115D7G | KINDERCARE LEARNING CENTER |  | 804194560 |  | 0
20093878147602G0901C4115D7G | KINDERCARE LEARNING CENTER |  | 804194560 |  | 0
20093878147602G0901C4115D7G | LAKEWOOD LEARNING CENTER |  | 804194560 |  | 0
20093878147602G0901C4115D7G | LAKEWOOD LEARNING CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | LITTLE ANGEL'S DAYCARE |  | 802025328 |  | 0
20093878147602G0901C4115D7G | LITTLE BEAR'S CHILD CARE, INC. |  | 805221250 |  | 0
20093878147602G0901C4115D7G | LITTLE BRITCHES LEARNING CTR - WESTMINST |  | 800224811 |  | 0
20093878147602G0901C4115D7G | LITTLE DEBBIES DREAM CHILD CARE LRNG |  | 802025328 |  | 0
20093878147602G0901C4115D7G | LITTLE FRIENDS PRESCHOOL AND CHILD CTR |  | 802025328 |  | 0
20093878147602G0901C4115D7G | LITTLE GIANTS LEARNING CENTER |  | 800224811 |  | 0
20093878147602G0901C4115D7G | LITTLE HEARTS PRE-SCHOOL & CHILD CARE |  | 808130959 |  | 0
20093878147602G0901C4115D7G | LITTLE LEARNERS |  | 802025328 |  | 0
20093878147602G0901C4115D7G | LITTLE PEOPLE LANDING LEARNING CENTER |  | 804194560 |  | 0
20093878147602G0901C4115D7G | LITTLE PEOPLE'S LANDING LEARNING |  | 805221250 |  | 0
20093878147602G0901C4115D7G | LITTLE SAINTS DAY CARE AND LEARNING CENT |  | 802025328 |  | 0
20093878147602G0901C4115D7G | LITTLE STAR LEARNING CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | [NAME] IN LEARNING |  | 802025328 |  | 0
20093878147602G0901C4115D7G | LOWRY MONTESSORI |  | 802025328 |  | 0
20093878147602G0901C4115D7G | MOUNTAIN VIEW CHILD CARE CTR |  | 802025328 |  | 0
20093878147602G0901C4115D7G | MUNDO DE JUGUETE DAYCARE |  | 802025328 |  | 0
20093878147602G0901C4115D7G | PLAY-N-LEARN CHILD CARE |  | 802025328 |  | 0
20093878147602G0901C4115D7G | RENAISSANCE CHILDREN'S CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | RUDE PARK DAY CARE CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | SHINING STARS LEARNING CENTER |  | 803060471 |  | 0
20093878147602G0901C4115D7G | STEP BY STEP CHILD DEVELOPMENT CENTER |  | 800224811 |  | 0
20093878147602G0901C4115D7G | SUNSHINE ACADEMY LLC |  | 802025328 |  | 0
20093878147602G0901C4115D7G | THE COTTAGE SCHOOL |  | 803060471 |  | 0
20093878147602G0901C4115D7G | THREATS CHILDCARE CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | TINY HEARTS INC. |  | 802025328 |  | 0
20093878147602G0901C4115D7G | TINY TODDLE IN |  | 800224811 |  | 0
20093878147602G0901C4115D7G | VENTURE FOR SUCCESS CHILDCARE LEARNING |  | 802025328 |  | 0
20093878147602G0901C4115D7G | WARREN VILLAGE LEARNING CENTER I |  | 802025328 |  | 0
20093878147602G0901C4115D7G | WESTMINSTER LEARNING CENTER |  | 800224811 |  | 0
20093878147602G0901C4115D7G | WESTWOOD CHILD DEVELOPMENT CENTER |  | 802025328 |  | 0
20093878147602G0901C4115D7G | YOUNG ENTHUSIASTIC SCHOLARS |  | 802025328 |  | 0
20093878147602G0901C4115D7G | YOURS AND OUR LITTLE LOVES, INC. |  | 802025328 |  | 0
20093878147602H390A090006G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 802031702 | 7307044 | 176137 | Vocational Rehabilitation Services to States, Recovery Act | IT system related - Project Managers, Support Desk, Special Projects | 0.4
20093878147602H390A090006G | ALLIANCE ENTERPRISES INC |  | 985161312 |  | 176137 | CAP PERSONAL SVCS-IT/SOFTWARE
20093878192483B-09-DY-08-001G | LOCAL AFFAIRS, COLORADO DEPARTMENT OF |  | 802032241 | 2861220 | 0 | Public facility infrastructure projects in three (3) non-entitlement communities (Community Development Block Grants). | none | 0
20093878192483B-09-DY-08-001G | BENT, COUNTY OF | BENT COUNTY | 810540350 | 415000 | 0
20093878192483B-09-DY-08-001G | Boone Town Hall | Town of Boone | 810250013 | 1295000 | 0
20093878192483B-09-DY-08-001G | REDCLIFF, TOWN OF | REDCLIFF TOWN GOVERNMENT | 816490040 | 1122608 | 0
20093878192483G-0901COCOS2G | LOCAL AFFAIRS, COLORADO DEPARTMENT OF |  | 802032241 | 8684648 | 6536.23 | Community Service Block Grant (CSBG) ARRA funds for 40 eligible grantees to provide services to individuals at or below 200% of poverty. | Housing Counselor\n\nCareer Counselor\n\nAcademic Adviser\n\nDog Groomer\n\nOffice Assistant/Bookkeeper\n\n | 5
20093878192483G-0901COCOS2G | ARAPAHOE, COUNTY OF DONE | ARAPAHOE COUNTY GOVERNMENT | 801205707 | 618654 | 0
20093878192483G-0901COCOS2G | BACA COUNTY OF | BACA COUNTY COURT HOUSE | 810731425 | 16557 | 0
20093878192483G-0901COCOS2G | BENT, COUNTY OF | BENT COUNTY | 810541109 | 21840 | 0
20093878192483G-0901COCOS2G | BOULDER, COUNTY OF | BOULDER COUNTY | 803060471 | 570045 | 0
20093878192483G-0901COCOS2G | BROOMFIELD, CITY AND COUNTY OF |  | 800201730 | 35103 | 0
20093878192483G-0901COCOS2G | CLEAR CREEK, COUNTY OF |  | 804442000 | 11075 | 0
20093878192483G-0901COCOS2G | Colorado East Community Action Agency | Nu 2 U Khrift Store | 808360416 | 55926 | 1505.23
20093878192483G-0901COCOS2G | CROWLEY, COUNTY OF |  | 810631098 | 14435 | 0
20093878192483G-0901COCOS2G | DELTA, COUNTY OF | COUNTY COMMISSIONER OFFICE | 814161626 | 72328 | 0
20093878192483G-0901COCOS2G | DENVER, CITY & COUNTY OF | HUMAN SERVICES DEPT | 802043221 | 1720060 | 0
20093878192483G-0901COCOS2G | DOUGLAS, COUNTY OF |  | 801097804 | 81921 | 0
20093878192483G-0901COCOS2G | EAGLE COUNTY AIR TERMINAL CORPORATION |  | 816310660 | 71200 | 0
20093878192483G-0901COCOS2G | EL PASO, COUNTY OF |  | 809051409 | 891231 | 0
20093878192483G-0901COCOS2G | GARFIELD, COUNTY OF |  | 816014700 | 70869 | 0
20093878192483G-0901COCOS2G | GILPIN, COUNTY OF | HUMAN SERVICES | 804228771 | 4222 | 0
20093878192483G-0901COCOS2G | GUNNISON, COUNTY OF |  | 812302648 | 44343 | 0
20093878192483G-0901COCOS2G | COUNTY OF GRAND | GRAND COUNTY COURTHOUSE | 804510042 | 19917 | 0
20093878192483G-0901COCOS2G | COUNTY OF JACKSON | CLERK OFFICE | 804800338 | 4863 | 4863
20093878192483G-0901COCOS2G | KIOWA COUNTY |  | 810360100 | 4310 | 0
20093878192483G-0901COCOS2G | HOUSING SOLUTIONS FOR THE SOUTHWEST INC |  | 813036828 | 227262 | 0
20093878192483G-0901COCOS2G | HUERFANO-LAS ANIMAS AREA COUNCIL OF GOVERNMENTS | SOUTH CENTRAL COUNCIL OF GOVERNMENTS | 804772790 | 84441 | 0
20093878192483G-0901COCOS2G | JEFFERSON, COUNTY OF | COMMUNITY DEVELOPMENT | 804016001 | 592459 | 0
20093878192483G-0901COCOS2G | LARIMER, COUNTY OF |  | 805242004 | 499574 | 0
20093878192483G-0901COCOS2G | COUNTY OF MESA |  | 815025035 | 257546 | 0
20093878192483G-0901COCOS2G | Mexican American Development Association, Inc | Mada | 814013001 | 113045 | 0
20093878192483G-0901COCOS2G | COUNTY OF MOFFAT |  | 816252601 | 24006 | 0
20093878192483G-0901COCOS2G | NORTH EASTERN COLORADO ASSOCIATION OF LOCAL GOVERNMENTS |  | 807012168 | 179272 | 0
20093878192483G-0901COCOS2G | OTERO, COUNTY OF | COMMISIONERS OFFICE | 810500494 | 82076 | 0
20093878192483G-0901COCOS2G | Park County Senior Coalition |  | 804400309 | 17750 | 168
20093878192483G-0901COCOS2G | PITKIN, COUNTY OF |  | 816113125 | 20270 | 0
20093878192483G-0901COCOS2G | PROWERS, COUNTY OF |  | 810522842 | 60899 | 0
20093878192483G-0901COCOS2G | PUEBLO COUNTY GOVERNMENT | HOUSING & HUMAN SERVICES | 810014270 | 452026 | 0
20093878192483G-0901COCOS2G | RIO BLANCO, COUNTY OF |  | 816410345 | 12290 | 0
20093878192483G-0901COCOS2G | ROUTT, COUNTY OF | INFORMATION SYSTEMS | 804772790 | 26150 | 0
20093878192483G-0901COCOS2G | San Luis Valley Community Action Agency |  | 811400078 | 200428 | 0
20093878192483G-0901COCOS2G | COUNTY OF SUMMIT |  | 804431845 | 46376 | 0
20093878192483G-0901COCOS2G | COUNTY OF TELLER | TELLER, COUNTY OF | 808666956 | 24227 | 0
20093878192483G-0901COCOS2G | UPPER ARKANSAS AREA COUNCIL OF GOVERNMENTS |  | 812150510 | 165832 | 0
20093878192483G-0901COCOS2G | WELD, COUNTY OF |  | 806322014 | 486731 | 0
20093878192483S09-DY-08-0001G | LOCAL AFFAIRS, COLORADO DEPARTMENT OF |  | 802032241 | 8154036 | 0 | Will provide funds for homelessness prevention and re-housing in El Paso County and the City of Colorado Springs. | none | 0
20093878192483S09-DY-08-0001G | COLORADO COALITION FOR THE HOMELESS, THE | STOUT STREET CLINIC | 802052529 | 2182665 | 0
20093878192483S09-DY-08-0001G | COLORADO COALITION FOR THE HOMELESS, THE | STOUT STREET CLINIC | 802052529 | 5037663 | 0
20093878192483S09-DY-08-0001G | COLORADO SPRINGS CITY GOVERNMENT | [NAME] TRANSIT | 809033104 | 795668 | 0
200938782088262F-97881401-0G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802031942 | 34352000 | 960406 | Drinking Water State Revolving Fund | Construction and Administration Jobs, such as, plumbers, electricians, pipe fitters, laborers, heavy equipment operators, carpenters, painters and administrative and supervisory personnel. | 0
200938782088262F-97881401-0G | Seibert City Hall |  | 808340224 | 1719500 | 0
200938782088262F-97881401-0G | Hiland Acres Water & Sani |  | 806029999 | 1200000 | 102258
200938782088262F-97881401-0G | GEORGETOWN, TOWN OF | TOWN HALL | 804449999 | 3340000 | 0
200938782088262F-97881401-0G | Brighton City Government |  | 806019999 | 1044000 | 0
200938782088262F-97881401-0G | COLORADO CITY METROPOLITAN DISTRICT |  | 810199999 | 1780000 | 164930
200938782088262F-97881401-0G | DIVIDE MPC METROPOLITAN DISTRICT NO 1 |  | 808149999 | 145930 | 0
200938782088262F-97881401-0G | [NAME], Town Of, Inc |  | 804429999 | 652255 | 0
200938782088262F-97881401-0G | MANITOU SPRINGS, CITY OF | POLICE DEPARTMENT | 808299999 | 3852801 | 0
200938782088262F-97881401-0G | [NAME], TOWN OF |  | 808100125 | 1732517 | 56518
200938782088262F-97881401-0G | FLORENCE, CITY OF |  | 812261143 | 2000000 | 0
200938782088262F-97881401-0G | CITY OF LA JUNTA |  | 810509999 | 1830000 | 0
200938782088262F-97881401-0G | KREMMLING, TOWN OF |  | 804599999 | 2000000 | 0
200938782088262F-97881401-0G | BLANCA, TOWN OF | TOWN HALL | 811230190 | 50000 | 0
200938782088262F-97881401-0G | ROCKY FORD, CITY OF |  | 810679999 | 945337 | 0
200938782088262F-97881401-0G | City Hall of Kit Carson | Town Hall of Kit Carson | 808250375 | 392000 | 0
200938782088262F-97881401-0G | Town of Norwood | [NAME] | 814239999 | 540150 | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262F-97881401-0G |  |  |  |  | 0
200938782088262S-97881701-0G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 804224600 | 2160000 | 286301.82 | ARRA Hazardous Substances Response Trust Fund - Clear Creek Superfund Project | .01 for Project management/oversight and administrative support.\n\n4.87 Heavy equipment operators and laborers | 4.97
200938782088262S-97881701-0G | MCCOLLUMS EXCAVATING LLC |  | 804660000 |  | 274515.12 | PERSONAL SVCS - PROFESSIONAL
200938782088262W-97880801-0G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802031942 | 31347700 | 349006 | Clean Water State Revolving Fund | Construction and Administration Jobs, such as, plumbers, electricians, pipe fitters, laborers, heavy equipment operators, carpenters, painters and administrative and supervisory personnel. | 0
200938782088262W-97880801-0G | Town of Bayfield |  | 811229999 | 193956 | 0
200938782088262W-97880801-0G | ERIE, TOWN OF |  | 805169999 | 2000000 | 0
200938782088262W-97880801-0G | GEORGETOWN, TOWN OF | TOWN HALL | 804449999 | 5800000 | 0
200938782088262W-97880801-0G | GUNNISON, COUNTY OF |  | 812309999 | 474019 | 0
200938782088262W-97880801-0G | Pagosa Area Water & Sanitation District |  | 811579999 | 6111224 | 0
200938782088262W-97880801-0G | REDCLIFF, TOWN OF | REDCLIFF TOWN GOVERNMENT | 816499999 | 2000000 | 0
200938782088262W-97880801-0G | Fremont Sanitation District |  | 812129999 | 2000000 | 0
200938782088262W-97880801-0G | MANITOU SPRINGS, CITY OF | POLICE DEPARTMENT | 808299999 | 2083401 | 0
200938782088262W-97880801-0G | CITY OF PUEBLO |  | 810033488 | 1500000 | 0
200938782088262W-97880801-0G | MONUMENT SANITATION DISTRICT |  | 801329999 | 2000000 | 0
200938782088262W-97880801-0G | WIDEFIELD WATER & SANITATION COMPANY | WASTE WATER PLANT | 809119999 | 1728593 | 0
200938782088262W-97880801-0G |  |  |  |  | 0
200938782088262W-97880801-0G |  |  |  |  | 0
200938782088262W-97880801-0G |  |  |  |  | 0
200938782088262W-97880801-0G |  |  |  |  | 0
200938782088262W-97880801-0G |  |  |  |  | 0
200938782088262W-97880801-0G |  |  |  |  | 0
200938782088262W-97880801-0G |  |  |  |  | 0
200938782088262W-97880801-0G |  |  |  |  | 0
200938782088262W-97880801-0G |  |  |  |  | 0
200938782088262W-97880801-0G |  |  |  |  | 0
200938782088262W-97880801-0G |  |  |  |  | 0
20093878209295AA-17111-08-55-A-8G | LABOR & EMPLOYMENT, COLORADO DEPARTMENT OF |  | 802023660 | 31132248 | 8490976.51 | RECOVERY-ACT-WORKFORCE INVESTMENT ACT-DISLOCATED WORKERS FY09/RECOVERY-ACT-WIA-ADULT/RECOVERY-ACT-WIA-YOUTH FY09 | 1. WORKFORCE INVESTMENT ACT(WIA)-DISLOCATED WORKERS 19.10 FTE [CFDA 17.260]\n\n2. WORKFORCE INVESTMENT ACT -ADULT WORKERS 24.70 FTE \n\n[CFDA 17.258]\n\n3. WORKFORCE INVESTMENT ACT -YOUTH WORKERS 266.30 FTE \n\n[CFDA 17.259]\n\nCreated case management staff who provide employment and training related services to eligible adults and youth.  Also, for the Youth program, includes 201.54 FTE in summer youth placements. | 310.1
20093878209295AA-17111-08-55-A-8G | ADAMS, COUNTY OF |  | 802343424 | 774851 | 0
20093878209295AA-17111-08-55-A-8G | BOULDER, COUNTY OF | BOULDER COUNTY | 803041824 | 117629 | 0
20093878209295AA-17111-08-55-A-8G | DENVER, CITY & COUNTY OF | MAYOR'S OFFICE OF ECONOMIC DEVELOPMENT | 802025332 | 837159 | 0
20093878209295AA-17111-08-55-A-8G | EL PASO, COUNTY OF |  | 809096003 | 951755 | 0
20093878209295AA-17111-08-55-A-8G | County of Larimer | Employment & Training Services | 805222367 | 125046 | 0
20093878209295AA-17111-08-55-A-8G | WELD, COUNTY OF |  | 806312014 | 213221 | 0
20093878209295AA-17111-08-55-A-8G | COUNTY OF MESA |  | 815025035 | 94704 | 9173
20093878209295AA-17111-08-55-A-8G | ARAPAHOE, COUNTY OF DONE | ARAPAHOE COUNTY GOVERNMENT | 801111914 | 0 | 0
20093878209295AA-17111-08-55-A-8G | BROOMFIELD, CITY AND COUNTY OF |  | 800202495 | 62567 | 13519.06
20093878209295AA-17111-08-55-A-8G | UPPER ARKANSAS AREA COUNCIL OF GOVERNMENTS |  | 812129380 | 99513 | 8121.52
20093878209295AA-17111-08-55-A-8G | ROCKY MOUNTAIN S E R/ JOBS FOR PROGRESS INC |  | 802113057 | 264114 | 31163.64
20093878209295AA-17111-08-55-A-8G | ADAMS, COUNTY OF |  | 802343424 | 2858673 | 1548038.48
20093878209295AA-17111-08-55-A-8G | BOULDER, COUNTY OF | BOULDER COUNTY | 803041824 | 513769 | 288267.79
20093878209295AA-17111-08-55-A-8G | DENVER, CITY & COUNTY OF | MAYOR'S OFFICE OF ECONOMIC DEVELOPMENT | 802025332 | 1892436 | 1122539.18
20093878209295AA-17111-08-55-A-8G | EL PASO, COUNTY OF |  | 809096003 | 1472743 | 789058.53
20093878209295AA-17111-08-55-A-8G | JEFFERSON, COUNTY OF |  | 804016022 | 1762002 | 837955.83
20093878209295AA-17111-08-55-A-8G | County of Larimer | Employment & Training Services | 805222367 | 471691 | 372764.87
20093878209295AA-17111-08-55-A-8G | WELD, COUNTY OF |  | 806312014 | 634959 | 420998.48
20093878209295AA-17111-08-55-A-8G | ARAPAHOE, COUNTY OF DONE | ARAPAHOE COUNTY GOVERNMENT | 801111914 | 2613208 | 1152884.13
20093878209295AA-17111-08-55-A-8G | COUNTY OF MESA |  | 815015097 | 233940 | 186799
20093878209295AA-17111-08-55-A-8G | UPPER ARKANSAS AREA COUNCIL OF GOVERNMENTS |  | 812129380 | 95000 | 81879.51
20093878209295AA-17111-08-55-A-8G | SOUTHERN UTE COMMUNITY ACTION PROGRAMS INC | TRAINING ADVANTAGE , THE | 811370800 | 116700 | 84772.04
20093878209295AA-17111-08-55-A-8G | ADAMS, COUNTY OF |  | 802343424 | 2858673 | 0
20093878209295AA-17111-08-55-A-8G | EL PASO, COUNTY OF |  | 809096003 | 852593 | 0
20093878209295AA-17111-08-55-A-8G | County of Larimer | Employment & Training Services | 805222367 | 418176 | 0
20093878209295AA-17111-08-55-A-8G | WELD, COUNTY OF |  | 806312014 | 442413 | 0
20093878209295AA-17111-08-55-A-8G | ARAPAHOE, COUNTY OF DONE | ARAPAHOE COUNTY GOVERNMENT | 801111914 | 0 | 0
20093878209295AA-17111-08-55-A-8G | UPPER ARKANSAS AREA COUNCIL OF GOVERNMENTS |  | 812129380 | 121436 | 8006.56
20093878209295AA-17111-08-55-A-8G | SOUTHERN UTE COMMUNITY ACTION PROGRAMS INC | TRAINING ADVANTAGE , THE | 811370800 | 96537 | 19753.54
20093878209295AA-17111-08-55-A-8G | ROCKY MOUNTAIN S E R/ JOBS FOR PROGRESS INC |  | 802113057 | 219279 | 17329.01
20093878209295AA-17111-08-55-A-8G | COUNTY OF MESA |  | 815015097 | 159026 | 15119
20093878209295AA-17111-08-55-A-8G | BOULDER, COUNTY OF | BOULDER COUNTY | 803041824 | 383682 | 0
20093878209295AA-17111-08-55-A-8G | DENVER, CITY & COUNTY OF | MAYOR'S OFFICE OF ECONOMIC DEVELOPMENT | 802025332 | 1182537 | 0
20093878209295AA-17111-08-55-A-8G | SOUTHERN UTE COMMUNITY ACTION PROGRAMS INC | TRAINING ADVANTAGE , THE | 811370800 | 93607 | 13281.76
20093878209295AA-17111-08-55-A-8G | BROOMFIELD, CITY AND COUNTY OF |  | 800202495 | 91976 | 14279.33
20093878209295AA-17111-08-55-A-8G | ROCKY MOUNTAIN S E R/ JOBS FOR PROGRESS INC |  | 802113057 | 171000 | 149256.37
20093878209295AA-17111-08-55-A-8G | BROOMFIELD, CITY AND COUNTY OF |  | 800202495 | 93302 | 10842.09
20093878209295ES-17549-08-55-A-8G | LABOR & EMPLOYMENT, COLORADO DEPARTMENT OF |  | 802023660 | 6212434 | 723525.38 | RECOVERY ACT-EMPLOYMENT SERVICE FY09/RECOVERY ACT-RE-EMPLOYMENT SERVICES FY09 | WAGNER PEYSER-EMPLOYMENT SERVICES 13.2 FTE [CFDA 17.207] AND WAGNER PEYSER-REEMPLOYMENT SERVICES 10.2 FTE [CFDA 17.207]\n\nCreated workforce and administrative specialist's who help provide employment and training related services for both job seekers and business/employers.  Services include: assessment, job referral, job fairs, resume preparation, multi-level computer classes, interviewing skills, job readiness workshops, training and supportive services while attending training. | 23.4
20093878209295ES-17549-08-55-A-8G | County of Larimer | Employment & Training Services | 805222367 | 199493 | 23579.05
20093878209295ES-17549-08-55-A-8G | ADAMS, COUNTY OF |  | 802343424 | 0 | 0
20093878209295ES-17549-08-55-A-8G | BOULDER, COUNTY OF | BOULDER COUNTY | 803041824 | 89152 | 4168.84
20093878209295ES-17549-08-55-A-8G | DENVER, CITY & COUNTY OF | MAYOR'S OFFICE OF ECONOMIC DEVELOPMENT | 802025332 | 487054 | 104960.2
20093878209295ES-17549-08-55-A-8G | EL PASO, COUNTY OF |  | 809096003 | 260258 | 27433.33
20093878209295ES-17549-08-55-A-8G | JEFFERSON, COUNTY OF |  | 804016022 | 169297.35 | 92801.41
20093878209295ES-17549-08-55-A-8G | County of Larimer | Employment & Training Services | 805222367 | 119696 | 0
20093878209295ES-17549-08-55-A-8G | WELD, COUNTY OF |  | 806312014 | 121037 | 2299.85
20093878209295ES-17549-08-55-A-8G | COUNTY OF MESA |  | 815015097 | 90491 | 25638.17
20093878209295ES-17549-08-55-A-8G | BROOMFIELD, CITY AND COUNTY OF |  | 800202495 | 30362 | 1561.46
20093878209295ES-17549-08-55-A-8G | ARAPAHOE, COUNTY OF DONE | ARAPAHOE COUNTY GOVERNMENT | 801111914 | 264836 | 0
20093878209295ES-17549-08-55-A-8G | ADAMS, COUNTY OF |  | 802343424 | 568202 | 151359.42
20093878209295ES-17549-08-55-A-8G | ARAPAHOE, COUNTY OF DONE | ARAPAHOE COUNTY GOVERNMENT | 801111914 | 441394 | 0
20093878209295ES-17549-08-55-A-8G | BOULDER, COUNTY OF | BOULDER COUNTY | 803041824 | 148586 | 20358.78
20093878209295ES-17549-08-55-A-8G | DENVER, CITY & COUNTY OF | MAYOR'S OFFICE OF ECONOMIC DEVELOPMENT | 802025332 | 292232 | 103538.81
20093878209295ES-17549-08-55-A-8G | EL PASO, COUNTY OF |  | 809096003 | 433763 | 26675.77
20093878209295ES-17549-08-55-A-8G | WELD, COUNTY OF |  | 806312014 | 201729 | 8884.03
20093878209295ES-17549-08-55-A-8G | COUNTY OF MESA |  | 815015097 | 150817 | 14949.19
20093878209295ES-17549-08-55-A-8G | BROOMFIELD, CITY AND COUNTY OF |  | 800202495 | 50603 | 0
200938783555512009-EF-S6-0034G | PUBLIC SAFETY COLORADO DEPT | DIVISION OF CRIMINAL JUSTICE | 802155885 | 2306619 | 69346.23 | FY2009 Colorado VAWA Recovery Act Project | A total of 14.81 FTE was created or retained under the Community/Social/Victims Services category.  [NAME] of jobs included Legal and Victim Advocates, therapists and counselors, specialized prosecution and law enforcement, trainers, Sexual Assault Nurse Examiners, and Sexual Assault Response Team members. | 14.81
200938783555512009-EF-S6-0034G | COLORADO DISTRICT ATTORNEYS COUNCIL INC |  | 802031939 | 48949 | 0
200938783555512009-EF-S6-0034G | COLORADO COALITION AGAINST DOMESTIC VIOLENCE | C C A D V | 802032138 | 72500 | 0
200938783555512009-EF-S6-0034G | COLORADO COALITION AGAINST SEXUAL ASSAULT |  | 802030398 | 42022 | 0
200938783555512009-EF-S6-0034G | PARK, COUNTY OF |  | 804400604 | 35407 | 0
200938783555512009-EF-S6-0034G | HELP FOR ABUSED PARTNERS |  | 807511286 | 35898 | 0
200938783555512009-EF-S6-0034G | SARA INC |  | 807012312 | 41009 | 0
200938783555512009-EF-S6-0034G | 13TH JUDICIAL DISTRICT ATTORNEY OFFICE | VICTIM SERVICES | 807013614 | 72357 | 0
200938783555512009-EF-S6-0034G | GILPIN COUNTY VICTIMS ADVOCATE |  | 804228709 | 37990 | 0
200938783555512009-EF-S6-0034G | ARKANSAS VALLEY RESOURCE CENTER INC | ARVC | 810500716 | 30000 | 0
200938783555512009-EF-S6-0034G | ALTERNATIVE TO FAMILY VIOLENCE INC |  | 800370385 | 25655 | 0
200938783555512009-EF-S6-0034G | CHI COLORADO FOUNDATION |  | 802041335 | 100570 | 0
200938783555512009-EF-S6-0034G | GATEWAY BATTERED WOMEN'S SHELTER |  | 800400914 | 53887 | 0
200938783555512009-EF-S6-0034G | SAFEHOUSE PROGRESSIVE ALLIANCE FOR NONVIOLENCE, INC. |  | 803043223 | 59699 | 0
200938783555512009-EF-S6-0034G | DENVER, CITY & COUNTY OF | DISTRICT ATTORNEY- ADMIN | 802025328 | 185961 | 0
200938783555512009-EF-S6-0034G | SAFE HOUSE DENVER INC |  | 802181528 | 44213 | 0
200938783555512009-EF-S6-0034G | DENVER, CITY & COUNTY OF | POLICE DEPT | 802040098 | 286323 | 0
200938783555512009-EF-S6-0034G | DROSTE, MARIA SERVICES OF COLORADO |  | 802223305 | 63375 | 0
200938783555512009-EF-S6-0034G | DENVER, CITY & COUNTY OF | DISTRICT ATTORNEY- ADMIN | 802025328 | 105658 | 0
200938783555512009-EF-S6-0034G | CENTRO DE LA FAMILIA |  | [NAME] | 25740 | 0
200938783555512009-EF-S6-0034G | RESOURCE CENTER OF EAGLE COUNTY, THE | BRIGHT FUTURE FOUNDATION, THE | 816202558 | 40023 | 0
200938783555512009-EF-S6-0034G | VIOLENCE PREVENTION COALITION OF SW COLORADO |  | 813023269 | 84657 | 7000
200938783555512009-EF-S6-0034G | CROSSROADS SAFE HOUSE |  | 805220993 | 80159 | 0
200938783555512009-EF-S6-0034G | ALTERNATIVES TO VIOLENCE INC | ALTERNATIVES FOR BATTERED WOMEN | 805375603 | 38309 | 0
200938783555512009-EF-S6-0034G | LARIMER, COUNTY OF | 8TH JUDICIAL DISTRICT | 805212763 | 88819 | 0
200938783555512009-SF-B9-0133G | PUBLIC SAFETY COLORADO DEPT | DIVISION OF CRIMINAL JUSTICE | 802155885 | 929310 | 6786.51 | Recovery Act - OVC FY 09 VOCA Victim Compensation Formula Grant Program | none | 0
200938783555512009-SF-B9-0133G | ADAMS, COUNTY OF | DISTRICT ATTORNEY OFFICE-17TH JUDICIAL DISTRICT | 806018802 | 340000 | 0
200938783555512009-SG-B9-0142G | PUBLIC SAFETY COLORADO DEPT | DIVISION OF CRIMINAL JUSTICE | 802155885 | 827000 | 32347.38 | Recovery Act - OVC FY09 VOCA Victims Assistance Formula Grant Program | 11.3 FTE Community/Social/Victims Services jobs created or retained (e.g.  Victim Advocates, [NAME], [NAME]). | 11.3
200938783555512009-SG-B9-0142G | 13TH JUDICIAL DISTRICT ATTORNEY OFFICE | VICTIM SERVICES | 807013614 | 34515 | 0
200938783555512009-SG-B9-0142G | [NAME], COUNTY OF |  | 808076174 | 28060 | 0
200938783555512009-SG-B9-0142G | ADAMS, COUNTY OF | DISTRICT ATTORNEY OFFICE-17TH JUDICIAL DISTRICT | 806018802 | 82289 | 0
200938783555512009-SG-B9-0142G | KEMPE FOUNDATION FOR THE PREVENTION AND TREATMENT | KEMPE FOUNDATION , THE | 800457106 | 39150 | 0
200938783555512009-SG-B9-0142G | DOUGLAS, COUNTY OF |  | 801097543 | 36818 | 0
200938783555512009-SG-B9-0142G | SAFEHOUSE PROGRESSIVE ALLIANCE FOR NONVIOLENCE, INC. |  | 803043223 | 46502 | 0
200938783555512009-SG-B9-0142G | DENVER CENTER FOR CRIME VICTIMS, THE |  | 802180975 | 63000 | 0
200938783555512009-SG-B9-0142G | DENVER, CITY & COUNTY OF | DISTRICT ATTORNEY- ADMIN | 802020975 | 50909 | 0
200938783555512009-SG-B9-0142G | PROJECT PAVE INC |  | 802055713 | 34173 | 0
200938783555512009-SG-B9-0142G | SERVICIOS DE LA RAZA INC |  | 802112214 | 29895 | 0
200938783555512009-SG-B9-0142G | CASA OF PIKES PEAK REGION |  | 809033900 | 31050 | 0
200938783555512009-SG-B9-0142G | CHILD SAFE RESEARCH & TREATMENT FOUNDATION, INC. | CHILDSAFE | 805243926 | 43364 | 0
200938783555512009-SG-B9-0142G | CROSSROADS SAFE HOUSE |  | 805220993 | 50000 | 0
200938783555512009-SG-B9-0142G | SEXUAL ASSAULT VICTIM ADVOCATE CENTER | SAVA CENTER | 805212602 | 58500 | 0
200939607387710063031G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 815219999 | 686073 | 0 | Fruita - US 6 Trail Enhancement | To create or retain professional, technical, and labor jobs in the transportation industry | 0.7
200939607387710063031G | Fruita, City of (inc) | City Offices of Fruita | 815219999 | 433399 | 0
200939607387710063031G | Mays Construction Specialties |  | 815059999 |  | 0 | PED/BIKE TRAIL ALONG SH-6 BETWEEM K RD AMD COULSON RD.
20093960738771006A043G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 816579999 | 375000 | 0 | Minturn-Dowd [NAME] | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771006A043G | Minturn, Town Of |  | 816579999 | 375000 | 0
20093960738771006A043G | [NAME] |  | 804249999 |  | 0 | CONSTRUCT A BIKE/PED TRAIL.
200939607387710091032G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 804249999 | 8994331 | 2851330 | SH9: BRECKENRIDGE NORTH, WIDEN FROM 2 LANES TO 4, ADD CURB & GUTTER, STORM DRAIN | To create or retain professional, technical, and labor jobs in the transportation industry | 26.19
200939607387710091032G | ZAK DIRT INC |  | 805049999 |  | 2390952.91 | WIDEN FROM 2 LANES TO 4, ADD CURB & GUTTER, STORM DRAIN
200939607387710131055G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 816419999 | 10439448 | 90547 | SH 13 AT RIO BLANCO HILL IN RIO BLANCO COUNTY, RECONSTRUCTION AND OTHER IMPROVEMENTS | To create or retain professional, technical, and labor jobs in the transportation industry | 6.68
200939607387710131055G | ELAM CONSTRUCTION INC |  | 815019999 |  | 77146.33
200939607387710141020G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 805129999 | 5478898 | 2351886 | SH 14: HATCHERY TO CAMERON PASS, SURFACE TREATMENT ON SH 14 FROM CAMERON PASS EAST. | To create or retain professional, technical, and labor jobs in the transportation industry | 14.3
200939607387710141020G | LAFARGE NORTH AMERICA INC |  | 805049999 |  | 1974840.59 | SURFACE TREATMENT ON SH 14 FROM CAMERON PASS EAST.
200939607387710242045G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 812119999 | 5064720 | 16480 | US24/285 JOHNSON VILLAGE NORTH, RESURFACING | To create or retain professional, technical, and labor jobs in the transportation industry | 10.85
200939607387710242045G | ASPHALT PAVING CO |  | 804039999 |  | 1380599.49 | resurfacing
200939607387710243076G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 808319999 | 3463203 | 0 | US 24 EAST BRIDGE (I-18-G OVER DRAW), REPLACEMENT OF SD BRIDGE/RELATED DRAINAGE IMPROVEMENTS | To create or retain professional, technical, and labor jobs in the transportation industry | 0.9
200939607387710243076G | SCOTT CONTRACTING INC |  | 806409999 |  | 0 | REPLACEMENT OF SD BRIDGE/RELATED DRAINAGE IMPROVEMENTS
200939607387710243076G | STATE OF COLORADO |  | 806409999 |  | 0 | REPLACEMENT OF SD BRIDGE/RELATED DRAINAGE IMPROVEMENTS
200939607387710251335G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 810829999 | 7044806 | 325294 | I-25 THROUGH TRINIDAD (LAS ANIMAS COUNTY VARIOUS IMPROVEMENT, RECONSTRUCTION (REALIGNMENT) OF SB I-25 BETWEEN COMMERCIAL S | To create or retain professional, technical, and labor jobs in the transportation industry | 6.17
200939607387710251335G | [NAME] |  | 801259999 |  | 271996.61 | RECONSTRUCTION (REALIGNMENT) OF SB I-25 BETWEEN COMMERCIAL S
200939607387710252402G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802049999 | 4190706 | 243935 | I-25:US6 TO 23RD AVE OVERLAY | To create or retain professional, technical, and labor jobs in the transportation industry | 20.5
200939607387710252402G | BRANNAN SAND & GRAVEL COMPANY LLC |  | 802299999 |  | 542228.4 | HMA MILL & OVERLAY
200939607387710253206G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 805389999 | 6859424 | 2011008 | I-25 Rubbilization N. of SH 34. | To create or retain professional, technical, and labor jobs in the transportation industry | 14.34
200939607387710253206G | AGGREGATE INDUSTRIES-WCR |  | 804013219 |  | 1669009.66 | RUBBILIZE EXISTING CONCRETE PAVEMENT AND OVERLAY W/ASPHALT
200939607387710253206G | STATE OF COLORADO |  | 804013219 |  | 0 | RUBBILIZE EXISTING CONCRETE PAVEMENT AND OVERLAY W/ASPHALT
200939607387710342050G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 806319999 | 462227 | 0 | US 34 & CR 49 (KERSEY) INTERSECTION SIGNAL, INTERSECTION SIGNALIZATION | To create or retain professional, technical, and labor jobs in the transportation industry | 0.04
200939607387710342050G | DKS ENTERPRISES INC |  | 806019999 |  | 0 | INTERSECTION SIGNALIZATION
200939607387710361089G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 805409999 | 1652568 | 0 | US 36 Chip Seal From Lyons To Estes Park | To create or retain professional, technical, and labor jobs in the transportation industry | 13.21
200939607387710361089G | OLDCASTLE SW GROUP INC |  | 815059999 |  | 505792.7 | CHIP SEAL ON US 36 (M.P. 1.55 TO 21.77)-ESTES PARK TO LYONS
200939607387710361090G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 803049999 | 386913 | 0 | US 36 & BROADWAY (BOULDER) INTERSECTION SIGNALIZATION, BUILD A NEW SIGNAL AND BIKE LANES | To create or retain professional, technical, and labor jobs in the transportation industry | 2
200939607387710361090G | DKS ENTERPRISES INC |  | 806019999 |  | 38700.5 | BUILD A NEW SIGNAL AND BIKE LANES
200939607387710361090G | STATE OF COLORADO |  | 806019999 |  | 0 | BUILD A NEW SIGNAL AND BIKE LANES
20093960738771052A031G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 805049999 | 4978205 | 0 | SH 52: AT BOULDER CR (W/O COUNTY LINE), REPLACEMENT OF A BRIDGE ON SH 52 IN BOULDER COUNTY | To create or retain professional, technical, and labor jobs in the transportation industry | 1.59
20093960738771052A031G | SEMA CONSTRUCTION, INC. |  | 801129999 |  | 0 | REPLACEMENT OF A BRIDGE ON SH 52 IN BOULDER COUNTY
20093960738771060A013G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 805349999 | 493383 | 48385 | SH60 & I-25 (JOHNSTOWN) INTERSECTION, SIGNALIZE I-25 ON&OFF RAMPS AND FRONTAGE RD. | To create or retain professional, technical, and labor jobs in the transportation industry | 3.03
20093960738771060A013G | W L CONTRACTORS INC |  | 800039999 |  | 40613.5 | SIGNALIZE I-25 ON&OFF RAMPS AND FRONTAGE RD.
20093960738771062A013G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 814309999 | 10236335 | 4000000 |  | To create or retain professional, technical, and labor jobs in the transportation industry | 41.01
20093960738771062A013G | [NAME] |  | 804039999 |  | 8206832.61 | HMA OVERLAY, GUARDRAIL REPLACE/MODIFY, SUPER CORRECTION
200939607387710701197G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 815269999 | 1339461 | 0 | [NAME] INTERCHANGE EXIT 42, SAFETY IMPROVEMENTS | To create or retain professional, technical, and labor jobs in the transportation industry | 0.53
200939607387710701197G | OLDCASTLE SW GROUP INC |  | 815059999 |  | 0 | SAFETY IMPROVEMENTS
200939607387710702283G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 804439999 | 9673746 | 6227629 | [NAME] PASS RESURFACING | To create or retain professional, technical, and labor jobs in the transportation industry | 36.55
200939607387710702283G | ASPHALT PAVING CO |  | 804039999 |  | 5599862.09 | RESURFACING
200939607387710703350G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 800029999 | 2240334 | 1417443 | I-70: KIPLING TO WADSWORTH RESURFACING, CONCRETE SLAB REPAIR WITH JOINT SEAL AND CROSS STITCH | To create or retain professional, technical, and labor jobs in the transportation industry | 17.14
200939607387710703350G | NEW DESIGN CONSTRUCTION COMPANY |  | 802297540 |  | 1179897 | CONCRETE SLAB REPAIR WITH JOINT SEAL AND CROSS STITCH
200939607387710703353G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 804529999 | 2014974 | 146268 | [NAME] | To create or retain professional, technical, and labor jobs in the transportation industry | 4.43
200939607387710703353G | STURGEON ELECTRIC CO INC |  | 802179999 |  | 187007 | ITS DEVICES FOR TRUCK PARKING ON I-70 WEST AT CHAIN STATIONS
200939607387710704217G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 800119999 | 328632 | 277910 | [NAME] TO TOWER RD, INSTALL MEDIAN CABLE BARRIER | To create or retain professional, technical, and labor jobs in the transportation industry | 2.13
200939607387710704217G | IDEAL FENCING CORPORATION |  | 805169477 |  | 230774.52 | INSTALL MEDIAN CABLE BARRIER
200939607387710761200G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 806409999 | 3767466 | 907179 | I-76 AND 96TH AVE ROUNDABOUTS | To create or retain professional, technical, and labor jobs in the transportation industry | 11.4
200939607387710761200G | CASTLE ROCK CONST CO OF COLO LLC |  | 801119999 |  | 757209.59 | ROUNDABOUTS AT I-76 AND 96TH AVE RAMP INTERSECTIONS
200939607387710761201G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 800229999 | 10876514 | 2575029 | I-76 OVER UPRR/SH-224 BRIDGE REPLACEMENT | To create or retain professional, technical, and labor jobs in the transportation industry | 10.82
200939607387710761201G | SEMA CONSTRUCTION, INC. |  | 801129999 |  | 2142160.5 | BRIDGE REPLACEMENT
200939607387710762045G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 807379999 | 15570336 | 2816256 | I-76: Sedgwick To NE St. Line Phase 3 | To create or retain professional, technical, and labor jobs in the transportation industry | 29.69
200939607387710762045G | INTERSTATE HIGHWAY CONST INC |  | 801559999 |  | 3141239.94 | RECONSTRUCTION
200939607387710821087G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 816019999 | 2674382 | 308304 | [NAME] 116 Improvements - Glenwood | To create or retain professional, technical, and labor jobs in the transportation industry | 21.19
200939607387710821087G | SCOTT CONTRACTING INC |  | 806409999 |  | 257479.05 | CONGESTION RELIEF AND INTERSECTION IMPROVEMENT
200939607387710821087G | STATE OF COLORADO |  | 806409999 |  | 0 | CONGESTION RELIEF AND INTERSECTION IMPROVEMENT
200939607387710852095G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 801259999 | 6384813 | 0 | US-85:C-470 TO CASTLE ROCK (WIDENING/OTHER IMPROVEMENTS), DOUGLAS COUNTY W/ PCCP, DRAINAGE, ROW, & RESURFACING | To create or retain professional, technical, and labor jobs in the transportation industry | 3.05
200939607387710852095G | LAWSON CONSTRUCTION COMPANY |  | 805015844 |  | 0 | DOUGLAS COUNTY W/ PCCP, DRAINAGE, ROW, & RESURFACING
20093960738771088A026G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 801209999 | 665530 | 425591 | BELLEVIEW: FEDERAL TO US 85 RESURFACING, RESURFACING | To create or retain professional, technical, and labor jobs in the transportation industry | 5.47
20093960738771088A026G | AGGREGATE INDUSTRIES-WCR |  | 802179999 |  | 354042.98 | RESURFACING
20093960738771092A022G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 814199999 | 9677646 | 282221 | SH 92 AUSTIN TO HOTCHKISS CORRIDOR, RECONSTRUCTION ADD SHOULDERS/CLIMBING LANES | To create or retain professional, technical, and labor jobs in the transportation industry | 11.55
20093960738771092A022G | TEZAK HEAVY EQUIPMENT COMPANY INC |  | 812123660 |  | 939522.16 | RECONSTRUCTION ADD SHOULDERS/CLIMBING LANES
200939607387711602122G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 811329999 | 1656292 | 0 | US 160 SHAW CREEK TO DEL NORTE, RESURFACING | To create or retain professional, technical, and labor jobs in the transportation industry | 4.89
200939607387711602122G | ELAM CONSTRUCTION INC |  | 815019999 |  | 0 | RESURFACING
200939607387711603027G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 811019999 | 3683041 | 2661126 | US 160 ALAMOSA EAST, RESURFACING | To create or retain professional, technical, and labor jobs in the transportation industry | 13.17
200939607387711603027G | ELAM CONSTRUCTION INC |  | 815019999 |  | 2207592.26 | RESURFACING
20093960738771160A010G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 813019999 | 3919600 |  | US 160 EAST OF DURANGO, NEW CONSTRUCTION | To create or retain professional, technical, and labor jobs in the transportation industry | 0.02
20093960738771160A010G | SEMA CONSTRUCTION, INC. |  | 801129999 |  | 0 | NEW CONSTRUCTION
20093960738771177A006G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 801229999 | 1941271 | 1540412 | UNIVERSITY: C470 TO ARAPAHOE RESURFACING, MILL AND OVERLAY | To create or retain professional, technical, and labor jobs in the transportation industry | 9.76
20093960738771177A006G | LAFARGE NORTH AMERICA INC |  | 805049999 |  | 1276598.09 | MILL AND OVERLAY
20093960738771257A007G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 805509999 | 344070 | 4703 | SH 257 & GARDEN DR. (WINDSOR) INTERSECTION SIGNALIZATION, SIGNALIZE INTERSECTION | To create or retain professional, technical, and labor jobs in the transportation industry | 0.06
20093960738771257A007G | W L CONTRACTORS INC |  | 800039999 |  | 85.33 | SIGNALIZE INTERSECTION
200939607387712852016G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 811499999 | 4779826 | 0 | US 285 SAGUACHE COUNTY, RESURFACING | To create or retain professional, technical, and labor jobs in the transportation industry | 16.98
200939607387712852016G | ELAM CONSTRUCTION INC |  | 815019999 |  | 0 | RESURFACING
200939607387712854117G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 804709999 | 8400000 | 0 | US 285: FOXTON RD TO PARK/JEFFERSON COUNTY LINE, CONSTRUCT A GRADE SEPARATED INTERCHANGE US285 AND ELK CR. RD | To create or retain professional, technical, and labor jobs in the transportation industry | 1.11
200939607387712854117G | HUDICK EXCAVATING INC |  | 801099999 |  | 119528.75 | CONSTRUCT A GRADE SEPARATED INTERCHANGE US285 AND ELK CR. RD
200939607387712871032G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 810739999 | 15677776 | 0 | SOUTH US 287: CAMPO TO HUGO, RECONSTRUCTION | To create or retain professional, technical, and labor jobs in the transportation industry | 0.22
200939607387712871032G | LAWSON CONSTRUCTION COMPANY |  | 805015844 |  | 0 | RECONSTRUCTION
20093960738771340A015G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 815219999 | 2065880 | 0 | [NAME] TO WEST MONUMENT CORRIDOR, SIGNALIZATION & IMPROV-RECONSTRUCTION | To create or retain professional, technical, and labor jobs in the transportation industry | 0.03
20093960738771340A015G | HEYL CONSTRUCTION INC |  | 816479999 |  | 0 | SIGNALIZATION & IMPROV-RECONSTRUCTION
200939607387714701118G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 801269999 | 31465789 | 2510484 | C-470: SANTA FE TO I-25 RESURFACING + C-470 BIKETRAIL, CPR/SMA OVERLAY FOR C-470 AND REHAB C-470 BIKE TRAIL | To create or retain professional, technical, and labor jobs in the transportation industry | 35.77
200939607387714701118G | CASTLE ROCK CONST CO OF COLO LLC |  | 801119999 |  | 2093688.82 | CPR/SMA OVERLAY FOR C-470 AND REHAB C-470 BIKE TRAIL
20093960738771C030035G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 805509999 | 625000 | 3940 | WCR 74: [NAME] 13 TO SH 257 (ARRA) (SURFACE TREATMENT), 3" MILL AND OVERLAY ON WELD COUNTY ROAD 74 | To create or retain professional, technical, and labor jobs in the transportation industry | 3.46
20093960738771C030035G | WELD, COUNTY OF |  | 805509999 | 625000 | 8268.82
20093960738771C030035G | Short [NAME], Inc |  | 802229999 |  | 8268.82
20093960738771C060049G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 805289999 | 600000 | 0 | ON SH 392, WEST OF THE CACHE LA POUDRE RIVER IN WINDSOR, CONCRETE BOX CULVERT FOR BIKE/PED TRAIL | To create or retain professional, technical, and labor jobs in the transportation industry | 1.1
20093960738771C060049G | County of Larimer | Public Works Admin | 805289999 | 600000 | 56220.39
20093960738771C060049G | Schmidt Earth Builders Inc |  | 805509999 |  | 56220.39 | CONCRETE BOX CULVERT FOR BIKE/PED TRAIL
20093960738771C060050G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 805269999 | 3485000 | 0 | LCR 1: FROM LCR 48 TO LCR 8, PATCHING AND RESURFACING ON LCR 17 | To create or retain professional, technical, and labor jobs in the transportation industry | 17.86
20093960738771C060050G | County of Larimer | Public Works Admin | 805269999 | 3485000 | 0
20093960738771C060050G | LaFarge West |  | 805219999 |  | 0 | PATCHING AND RESURFACING ON LCR 17
20093960738771C100028G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 801129999 | 1750200 | 446031 | INVERNESS DRIVE WEST, SOUTH OF DRY CREEK ROAD, CONSTRUCT NEW BIKE/PED BRIDGE OVER INVERNESS DRIVE | To create or retain professional, technical, and labor jobs in the transportation industry | 0.77
20093960738771C100028G | ARAPAHOE, COUNTY OF DONE | ARAPAHOE COUNTY GOVERNMENT | 801129999 | 637187 | 446031
20093960738771C100028G | White Construction |  | 801049999 |  | 446031 | CONSTRUCT NEW BIKE/PED BRIDGE OVER INVERNESS DRIVE
20093960738771CO-86-X001G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 804432179 | 10340000 | 0 | This grant allowed the county to build a new 42,000 sq. foot bus maintenance facility.  As a result of this project, the county will be more efficient in maintaining and servicing its fleet buses in a high altitude environment.\n\n | none | 0
20093960738771CO-86-X001G | AP Mountain States, LLC |  |  |  | 0 | Bus maintenance facility general contractor \n\n
20093960738771CO-86-X001G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 804432179 | 10300000 | 0
20093960738771M040017G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 800059999 | 300000 | 0 | W. 86TH PARKWAY BIKE LANES., COMPLETE MISSING LENGTH OF ATTACHED BIKE LANE ON SOUTH SIDE. | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M040017G | ARVADA, CITY OF (INC) |  | 800059999 | 300000 | 0
20093960738771M040017G | LaFarge North America Inc |  | 805049531 |  | 0 | COMPLETE MISSING LENGTH OF ATTACHED BIKE LANE ON SOUTH SIDE.
20093960738771M065003G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 811229999 | 250000 | 0 | BAYFIELD US 160 BUSINESS ROUTE PHASE II, CONSTRUCTION OF SIDEWALKS | To create or retain professional, technical, and labor jobs in the transportation industry | 5.81
20093960738771M065003G | Town of Bayfield |  | 811229999 | 200000 | 0
20093960738771M065003G | Schlessman Concrete Inc |  | 811229999 |  | 0 | CONSTRUCTION OF SIDEWALKS
20093960738771M110065G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 803049999 | 497624 | 0 | BOULDER ADA PEDESTRIAN ACCESS IMPROVEMENTS, ADA CURB RAMP INSTALLATIONS | To create or retain professional, technical, and labor jobs in the transportation industry | 0.23
20093960738771M110065G | BOULDER, CITY OF | FINANCE DEPARTMENT | 803049999 | 497624 | 0
20093960738771M110065G | Noraa Concrete |  | 806439999 |  | 0 | ADA CURB RAMP INSTALLATIONS
20093960738771M240121G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 809189999 | 35031818 | 0 | WOODMEN RD: I-25 TO POWERS BLVD, WIDEN WOODMEN ROAD WITH NEW INTERCHANGE AT ACADEMY BOULEVARD | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M240121G | COLORADO SPRINGS CITY GOVERNMENT | COLORADO SPRINGS CITY HALL | 809189999 | 35031818 | 0
20093960738771M240121G | Edward Kraemer & Sons |  | 535779999 |  | 0 | WIDEN WOODMEN ROAD WITH NEW INTERCHANGE AT ACADEMY BOULEVARD
20093960738771M356024G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 800309999 | 300000 | 0 | US36 TRAIL: BRADBURN BLVD. FROM 73RD AVE-TURNPIKE DRIVE, REPLACE 4' DETACHED SIDEWALK W/8' DETACHED SIDEWALK | To create or retain professional, technical, and labor jobs in the transportation industry | 5.35
20093960738771M356024G | WESTMINSTER, CITY OF |  | 800309999 | 260000 | 0
20093960738771M356024G | [NAME], Inc |  | 806438628 |  | 0 | REPLACE 4' DETACHED SIDEWALK W/8' DETACHED SIDEWALK
20093960738771M400004G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 805169999 | 733000 | 77606 | LEON A WURL BIKE LANES, FROM BONANZA DR. EAST TO I-25 INTERCHANGE (ERIE) | To create or retain professional, technical, and labor jobs in the transportation industry | 0.84
20093960738771M400004G | ERIE, TOWN OF |  |  | 90000 | 0
20093960738771M535004G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 816019999 | 649033 | 0 | I-70 PED BRIDGE-DEVEREUX RD. GLENWOOD, CONSTRUCT A PED BRIDGE OVER I-70 | To create or retain professional, technical, and labor jobs in the transportation industry | 1.34
20093960738771M535004G | GLENWOOD SPRINGS, CITY OF (INC) |  | 816019999 | 50000 | 0
20093960738771M535004G | Gould Construction |  | 816019999 |  | 0 | CONSTRUCT A PED BRIDGE OVER I-70
20093960738771M830047G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 805389999 | 250000 | 0 | US 34:WILSON INTERSECTION (ARRA) (INTERSECTION/SAFETY IMPRV), MEDIAN REPLACEMENT AND PAVING | To create or retain professional, technical, and labor jobs in the transportation industry | 2.37
20093960738771M830047G | LOVELAND, CITY OF |  | 805389999 | 250000 | 0
20093960738771M830047G | Mountain Constructors Inc |  | 806519999 |  | 0 | MEDIAN REPLACEMENT AND PAVING
20093960738771M935001G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 804669999 | 474000 | 0 | SH 119 ELDORA TO 2ND IN NEDERLAND BIKE, SIDEWALKS, CURB AND GUTTER, DRAINAGE | To create or retain professional, technical, and labor jobs in the transportation industry | 0.31
20093960738771M935001G | NEDERLAND, TOWN OF |  | 804669999 | 385000 | 40,000
20093960738771M935001G | New Design Construction |  | 802299999 |  | 40000 | SIDEWALKS, CURB AND GUTTER, DRAINAGE
20093960738771R100157G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 808219999 | 12248750 | 1777096 | US40/287:PORTS TO PLAINS CORRIDOR, CONCRETE RECONSTRUCTION, EMBANKMENT, DRAINAGE. | To create or retain professional, technical, and labor jobs in the transportation industry | 34.45
20093960738771R100157G | CASTLE ROCK CONST CO OF COLO LLC |  | 801119999 |  | 3274621.56 | CONCRETE RECONSTRUCTION, EMBANKMENT, DRAINAGE.
20093960738771R600340G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 801249999 | 333489 | 68705 | I-25, US 36 AND C-470 RAMP METERING (MULTIPLE LOCATIONS), INSTALL RAMP METERING | To create or retain professional, technical, and labor jobs in the transportation industry | 0.91
20093960738771R600340G | COLORADO BORING COMPANY |  | 805249999 |  | 57511.02 | INSTALL RAMP METERING
20093960738771R600343G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 804039999 | 886979 | 289462 | US6/ SH93/ SH58/ SH128 AT SIMMS -SIGNAL INSTALL/REPLACE, SIGNAL INSTALLATION AND UPGRADE | To create or retain professional, technical, and labor jobs in the transportation industry | 8.91
20093960738771R600343G | STURGEON ELECTRIC COMPANY, INC. |  | 802179999 |  | 285734.4 | SIGNAL INSTALLATION AND UPGRADE
20093960738771R600346G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802149999 | 3337195 | 1144633 | SH 40 (COLFAX): KIPLING TO SHERIDAN, RESURFACING | To create or retain professional, technical, and labor jobs in the transportation industry | 18.88
20093960738771R600346G | ASPHALT PAVING CO |  | 804039999 |  | 962616.39 | RESURFACING
200930074315051R01AI080709-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 370398 | 47000 | The envelope of Gram-negative bacteria consists of two membranes separated by the periplasmic compartment that contains the peptidoglycan wall. The inner membrane (IM) is in contact with the cytosol while the outer membrane (OM) contacts the extracellular | Post Doctorate, Graduate Student, Research Assistant | 3.2
200930074315051R01EB009115-01A1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 357192 | 51783.81 | Different electric and magnetic field (E/MF) configurations have been applied for non-invasive imaging therapies and surgery (laser) for many years. Unlike their higher energy counterparts, the biological mechanisms underlying the effects of exposure to l | Investigator, Post Doctorate, Graduate Student, Research Assistant | 2.32
200930074315051R01GM082917-01A1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 284529 | 0 | This work intends to survey specific RNAs associated with isolated membrane systems of cultured human cells. These RNAs are identified with specific sequences by array hybridization and massed sequencing. Identifed individual membrane-associated RNAs are subsequently screened for binding to purified phospholipid bilayers with the composition of human membranes, in the presence and absence of proteins. Residence on cellular membranes in vivo for RNAs with these biochemical properties is confirmed using FRET between RNA-complementary fluorescent oligonucleotides and membrane dyes introduced into living cells. The intended net effect ofthese three protocols is to detect a subset of membrane-resident RNAs in human cells that have bilayer affinity built into their covalent structures. |  | 0
200930074315051R01GM084133-01A1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 317292 | 73789.75 | The neural crest is a vertebrate innovation, sometimes referred to as the fourth germ layer; the neural crest gives rise to migrating cells that differentiate into cartilage, melanocytes, the peripheral nervous system, and the outflow tract of the heart. | Post Doctorate, Research Assistant | 3
200930074315051R01HL085705-01A2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 484032 | 16530.68 | Findings from survey studies indicate that the average American adult obtains an inadequate amount of sleep. Chronic sleep loss contributes to accidents and related deaths, poor job/school performance and poor health. In regards to health, short sleep dur | Post Doctorate, Graduate Student, Research Assistant | 2.78
200930074315051R03DA025740-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 189375 | 130236.18 | Opioid-induced glial activation, which compromises pain treatment and contributes to the development of drug addiction and abuse, is regulated via a signaling pathway downstream of toll-like receptor-4 (TLR4), a membrane spanning receptor that functions i | Graduate Student, Research Assistant | 2.5
200930074315051R03HD057270-01A2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 68050 | 0 | The health and nutrition of young children is of importance not only for the immediate improvement in their well-being but also because of the longer-term impacts on children's physical and cognitive development. It is believed that improvements in cognit |  | 0
200930074315051RC1DE020247-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 340875 | 0 | The critical features that predict the transition from acute to chronic pain remain unresolved. The present proposal explores whether microglial "priming" may be of particular importance in explaining the progression from acute to chronic pain. Activation |  | 0
200930074315051RC1MH088046-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 385018 | 0 | This application addresses Challenge Area 15 (Translational Science). Specific Challenge Topic 15-MH-109 Prefrontal cortex regulation of higher brain functions and complex behavior. There is growing emphasis on understanding what might produce resilience to the behavioral and neural impact of stress, and coping factors are thought to play a pivotal role. Behavioral control over the stressor is a key aspect of coping, and the presence of control not only blunts the effects of the stressor being controlled (Maier et al., 2006), but also reduces and even eliminates the behavioral and neurochemical changes produced by subsequent stressors, even if the subsequent stressor is not behaviorally controllable (Amat et al.,2006). That is, the experience of controlling a potent acute [NAME] appears to "immunize" the organism against the effects of later (acute) stress. Importantly, the ventral medial prefrontal cortex (vmPFC) has been shown to mediate both the immediate and proactive protective effects of behavioral control. The presence of control has been shown to activate top-down vmPFC inhibitory control over stress-responsive brainstem and limbic structures, thereby reducing the neurochemical impact of the stressor, as well as the behavioral sequelae of the activation of these structures (Amat et al.,2005). Furthermore, the experience of control over a potent stressor alters the vmPFC in such a way that subsequent stressors that are uncontrollable now activate vmPFC inhibitory control, thereby leading to protection against subsequent stressor exposure (Amat et al., 2006; Baratta et al, 2008). The research that has explored the resilience-inducing properties of control, as well as the role of the vmPFC in stress-resilience, has focused entirely on acute stress exposure. However, it is chronic stress that is most often implicated as an etiological factor in the development of a broad spectrum of psychiatric and somatic disorders. There has been virtually no study of experiential factors and mechanisms that might be important in producing resistance to the behavioral and neurochemical impact of chronic stress, and the present proposal is addressed at these issues. The research determines whether a) an experience with control over an acute stressor will prevent and/or reverse the impact of a chronic social stressor, adult social isolation, and b) the vmPFC is a critical mediator of these protective effects. Chronic stress is an etiological factor in the development of numerous disorders. Not all individuals exposed to chronic stress are severely impacted, and an understanding of factors that make individuals resilient are likely to lead to new treatments. The proposed research will determine whether a) the experience of behavioral control over a potent acute stressor before exposure to a different chronic stressor will prevent, and/or the experience of control after a chronic stressor reverse, the behavioral and neurochemical effects of the chronic stressor, and b) the protection is mediated by activation of the medial prefrontal cortex by control. |  | 0
200930074315051RC1NS067807-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 374730 | 0 | [NAME] pain remains intractable despite treatment with currently available therapeutic agents. Therefore, it is necessary to identify novel pharmacotherapeutics that can effectively attenuate neuropathic pain. Activation of microglia and astrocytes ( |  | 0
200930074315052R01GM059414-10A1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 294704 | 0 | Linear chromosomes terminate in specialized nucleoprotein structures called telomeres, which are required for genomic stability and cellular proliferation. Telomeres end in an unusual GT-rich 32 single-strand overhang that requires a special cap to preven |  | 0
200930074315052R01HD010333-31A2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 420846 | 2271.12 | The overarching goal of the Colorado Adoption Project (CAP) is to assess the genetic and environmental etiologies of individual differences in behavioral development. Toward this end, adoptive and nonadoptive probands and siblings have been tested almost | Investigator, Research Assistant | 2.5
200930074315052R56AI060841-06G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 368394 | 35848.13 | Cationic Antimicrobial Peptides (CAMPs) constitute a conserved branch of the innate immune system and is thus one of the first lines of defense against bacterial infections. Several clinical antibiotics, such as colistin and other polymyxins, also belong | Post Doctorate, Research Assistant | 2.6
200930074315053K22DE016608-04S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 11880 | 112.5 | This career transition award will provide the candidate with the opportunity to investigate new areas of research: mechanotransduction and mechanical stimulation for regenerating condylar cartilage of the temporomandibular joint (TMJ). The environment in | Research Assistant | 3
200930074315053P50HD027802-19S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 235369 | 0 | The Colorado Learning and Disablities Research Center (CLDRC) consists of an Administrative Cores and Five Component Projects that focus on the identification, characterization, validation and amelioration of reading disabilities (RD) and ADHD, the two most prevalent and often co-morbid disorders of childhood. The present application seeks ARRA Administrative Supplement funds in order to capitalize on our recent findings so as to significantly advance and augment important specific aims approved in the last competitive review of the CLDRC. We propose to collect additional data on our sample, expand our analyses (both behavioral and genetic), and further program development for intervention. Specifically, ARRA Subproject I will provide a more complete understanding of the stability of RD and ADHD and age differences by retesting some CLDRC participants that were previously tested approximately 5 years earlier, and conducting longitudinal analyses to complement the approved specific aim for cross-sectional development analyses in CLDRC Project I. ARRA Subproject 2 builds on our recent finding that outcomes of genetic analyses of independent variance for word recognition and reading comprehension vary depending of the specific test used to assess reading comprehension,  and will provide similar comparisons and analyses of other phenotypic measures including working memory, oral language , and word reading processes, complementing the specific aims to explore reading comprehension deficits in CLDRC Project II. ARRA Subproject 3 will advance our molecular genetic analyses with the latest DNA linkage and association analyses, complementing the specific aims for molecular-genetic analyses in CLDRC Project IV. ARRA Subproject 4 expands current work on program development, testing, and analyses for response to computer-based instruction for children with RD to complement the specific aims of CLDRC Project V that focus on response to instruction.  All of the proposed research supported by ARRA  funds will accelerate the achievement of previously approved specific aims, will enable additional analyses to augment those aims in ways that are consistent with peer-reviewed activities and aims approved within the parent grant, and will promote economic development. |  | 0
200930074315053R01AG006537-22S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 22422 | 2588.95 | This proposal seeks renewal of R01 AG006537 for years 20-24 to provide continuing support for our work in the integrative physiology of human aging. The proposed research will determine if caloric restriction- induced weight loss improves vascular endothe | Research Assistant | 1
200930074315053R01AG009000-15S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 11211 | 0 | Many older adults are less steady when exerting low forces and lifting light loads. The greater fluctuations in force exhibited by older adults can be caused either by increased discharge rate variability or by altered amounts of correlated activity among |  | 0
200930074315053R01AG031141-01A1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 22422 | 0 | This amended application seeks support for new work aimed at the treatment of vascular aging in humans. The proposed research will determine if habitual aerobic exercise improves endothelium-dependent dilation (EDD), a clinically important marker of vascu | Research Assistant | 0
200930074315053R01AI059764-05S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 20186 | 1522.42 | Herpes viruses comprise a large family of complex, double-stranded DNA viruses, a number of which are serious human pathogens. Herpes DNA replication requires a group of virally encoded proteins, and is the target of several antiviral drugs. However, the | Research Assistant | 2
200930074315053R01AI072492-03S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 86810 | 0 | Chronic bacterial infections cause significant morbidity and mortality worldwide. The World Health Organization estimates that 1.7 million people per year die from Mycobacterium tuberculosis infections, which can lie dormant in a healthy host for years. S |  | 0
200930074315053R01AR049446-05S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 157297 | 0 | Skeletal muscle is terminally differentiated and as such, cannot regenerate. The cells responsible for muscle regeneration are known as satellite cells, which are normally quiescent and reside between the basement membrane and the sarcolemma of the muscle |  | 0
200930074315053R01CA107098-06S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 342296 | 0 | Decreased levels of cell cycle inhibitor p27Kip1 due to excessive degradation occur in a variety of aggressive human tumors. Since reduced p27 expression has been associated with a poor prognosis in many human cancers and resistance to certain anti-tumor |  | 0
200930074315053R01CA107098-06S2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 99219 | 0 | The microbes that inhabit human bodies outnumber the human cells by an order of magnitude, and impact many aspects of health and disease including obesity, vaginosis, and Crohn's disease. Understanding this endogenous microbiota is emerging as a key exten |  | 0
200930074315053R01DA017670-05S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 42820 | 20338.57 | The core idea of this proposal is that: (a) substances released by neurons trigger the activation of glia, & (b) this glial activation, in turn, leads to the release of glial products that induce & maintain pain facilitation. It is clear from prior studie | Research Assistant | 4
200930074315053R01DA023132-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 42820 | 4119.98 | It has recently been discovered that glia become progressively more activated upon repeated exposure to morphine, & that this glial activation, in turn, [NAME] effects. This discovery was originally made in the context of studying the pain s | Research Assistant | 4
200930074315053R01DC006257-06S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 327480 | 0 | The aim of the proposed research is to assess the sensitivity of the latency of the P1 cortical auditory evoked potential as a marker of the development of the central auditory pathways in hearing impaired children who receive intervention through convent |  | 0
200930074315053R01DE017782-03S2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 21210 | 17287.14 | Chronic pain, including chronic orofacial pain, remains unsuccessfully treated in a large number of patients. Furthermore, the loss of analgesic efficacy with chronic administration of frontline analgesic drugs, such as morphine, severely limits their use | Research Assistant | 2
200930074315053R01EB006006-03S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 126713 | 3206.76 | Therapeutic proteins provide unique and critical treatments for many human diseases and conditions However, if a protein product cannot be stabilized adequately, its benefit to human health will never be realized. Proteins are highly susceptible to the fo | [NAME] | 2
200930074315053R01GM030228-21S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 205146 | 0 | The ability of cells, tissues, and organisms to sense and respond to changes in oxygen levels is often crucial to their survival. Cellular adaptation to hypoxia is a good example of this. Intermittent episodes of hypoxia are associated with a variety of h |  | 0
200930074315053R01GM051312-15S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 124812 | 0 | Centrosomes are the organelles at mitotic spindle poles that organize microtubules essential for chromosome segregation. Assembly of nascent centrosomes is a tightly regulated process that occurs exactly once each cell cycle. Defects in this process can l |  | 0
200930074315053R01GM055235-10S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 43060 | 0 | Interleukin-2 (IL-2) is a cytokine that functions in the mammalian immune response to infection. During an immune response, production of IL-2 is upregulated at the level of transcription by activators such as NFAT1 and cJun. The main goal of this researc |  | 0
200930074315053R01GM065505-06A1S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 246178 | 0 | Endosomes segregate endocytosed macromolecules destined to be degraded in the lysosome from molecules that are either recycled back to the cell surface or routed to other intracellular organelles. The multivesicular body (MVB) is a late endosome that contains vesicles formed by invagination of the endosomal membrane toward the compartmental lumen. Many growth factor receptors and stimulatory components of the immune system are sorted into MVB vesicles. Furthermore, human immunodeficiency virus-1 and other enveloped RNA viruses usurp components required for MVB vesicle formation in order to produce virions, thereby enabling the spread of viral infection. The objective of this application is to determine the molecular basis of MVB vesicle-mediated transport. Previous work on this project has identified mechanisms by which the [NAME] protein in Saccharomyces cerevisiae participates in the MVB cargo sorting pathway. The proposed work seeks to expand the scope of this analysis to understand the molecular mechanisms that regulate MVB vesicle formation. This process is impaired in cells lacking functional endosomal sorting complexes required for transport (ESCRTs) as a result of endosomes forming `class E compartments.' Preliminary studies suggest that class E compartment formation is driven by the accumulation of ubiquitinated proteins at endosomes and depends on endosomal tethering complexes. Specific aim 1 will determine the mechanism that regulates protein deubiquitination at endosomes, specific aim 2 will explore how ubiquitinated proteins and tethering components cooperate to create class E compartments, and specific aim 3 will investigate the mechanism that regulates polymerization of Snf7, which has been implicated as the driving force of MVB vesicle budding. All three specific aims will be pursued using a combination of genetic, biochemical, and microscopic studies to examine a variety of mutant yeast strains. PUBLIC HEALTH RELEVANCE: The proposed project seeks to understand the mechanistic regulation of the yeast ESCRT machinery, which is highly related to the ESCRT machinery that functions in human cells. In humans, the ESCRT machinery functions to downregulate many receptor-activated signal transduction pathways that control cell division, and tumorigenesis has been linked to mutations that disrupt ESCRT activity, making components of the ESCRT machinery candidate targets for gene therapy. The ESCRT machinery also is usurped by the human immunodeficiency virus-1 for the production of infectious virions, making components of the ESCRT machinery candidate targets for anti-viral therapies. |  | 0
200930074315053R01GM074746-04S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 53307 | 0 | Centrosomes are microtubule-organizing centers (MTOCs) consisting of two centrioles surrounded by pericentriolar material. Accurate centrosome duplication precisely once per cell cycle is required for formation of a bipolar mitotic spindle, the apparatus responsible for proper segregation of chromosomes during mitosis. Centrosome defects cause genetic instability and are evident in certain cancers. Centriole duplication is a critical event in centrosome duplication, and the events of centriole assembly are mechanistically similar to those of another MTOC, the basal body, which nucleates cilia or flagella. [NAME] and basal bodies are similar in structure, share many components, and the assembly of the two organelles require many of the same genes. We will investigate basal body assembly in the ciliated protozoan Tetrahymena thermophila. Among the conserved proteins found at centrioles and basal bodies is centrin, a small calcium-binding EF hand protein. We have studied four centrin genes in Tetrahymena. Of these, Cen1 localizes to basal bodies, and a CEN1 null allele reveals defects in basal body assembly and maintenance. We have identified additional components of basal bodies by Multidimensional Protein Identification Technololgy ([NAME]). This analysis has described well over 50 candidate basal body components which we propose to study. Initially, we will localize tagged versions of the proteins to confirm that they are basal body components. New components will be localized by [NAME] to identify those that localize to structures important in basal body assembly. These components will be subjected to genetic analysis, as done with Cen1, to determine whether they indeed have a role in basal body assembly or have another function at the basal body. Finally, the development of an in vitro assembly assay will contribute to a detailed understanding of centriole duplication. We believe that Tetrahymena is ideally suited for such an approach. We have established an in vitro centrin binding assay that has led to the identification of alpha and beta-tubulin as potential centrin binding partners at basal bodies, and we propose to study this interaction. We also will characterize an in vitro system that forms an early and important intermediate in basal body assembly. Overall, our approaches using Tetrahymena will identify new basal body and centriole components and define mechanisms for their roles in basal body and centriole assembly. |  | 0
200930074315053R01GM083849-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 204024 | 0 | This is a competitive revision of the grant GM083849 "Microfluidics-based selections for the optimization of red fluorescent proteins." The broad goal of this project is to develop fluorescent proteins with an 80-fold improvement in signal output (e.g. number of photons emitted before photobleaching). Over the last 10-15 years, fluorescent proteins have provided critical insights into the fundamental workings of the cell as they enable researchers to visualize protein movements, enzyme activities, gene expression, and to quantify important signaling molecules in real time in living cells. As a result, fluorescent proteins have truly revolutionized cell biology, shedding light on the basic biology of cellular function, while helping to elucidate what goes wrong in disease states. Substantial improvements in the signal output of fluorescent proteins are required for the next level: visualizing and monitoring of single molecules within individual living cells. We hypothesize that an 80-fold improvement in signal output can be obtained by explicitly engineering both the chromophore pocket and surface environment of fluorescent proteins. This revision will add a new specific aim to the original three aims. The two main goals of the new aim are: i) to use biophysical data to guide library design of red fluorescent proteins (RFPs) and ii) to provide a mechanistic link between improved photophysical properties and changes in protein structure and dynamics. This new aim expands upon the original aims by using state-of-the-art nuclear magnetic resonance (NMR) techniques to collect atomic level structural and dynamic data for RFP mutants, which will accelerate the overall goal of developing improved fluorescent proteins. These data will be used to develop correlations between changes in structure and dynamics and photophysical properties (photostability, dark-state conversion, and brightness). We propose a combination of NMR methodologies to investigate peptide backbone and side chain structure and dynamics. This information will define regions of local conformational flexibility to be targeted in library designs. This will provide a more informed starting point for library design and streamline our efforts to generate improved fluorescent proteins and thus will accelerate the goals of the original proposal. PUBLIC HEALTH RELEVANCE: The development of new fluorescent proteins with substantial increases in signal output will dramatically expand our ability to visualize and probe the inner workings of living cells. These imaging tools will impact public health by providing valuable insight into basic biology and mechanisms of disease progression. |  | 0
200930074315053R01GM084027-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 30382 | 0 | Transition metal ions are critical to life as we know it. 30% of all proteins contain a metal ion cofactor and these proteins play essential roles in fundamental processes such as respiration, oxygen transport and storage, cell division and migration, and |  | 0
200930074315053R01HG004872-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 326024 | 0 | The microbes that inhabit human bodies outnumber the human cells by an order of magnitude, and impact many aspects of health and disease including obesity, vaginosis, and Crohn's disease. Understanding this endogenous microbiota is emerging as a key exten |  | 0
200930074315053R21CA138373-01S3G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 54050 | 0 | Although many therapeutic strategies exist for molecular targets accessible from the outside of the cell (e.g. therapeutic antibodies) or within the cytoplasm (e.g. small molecule inhibitors), they are not applicable to molecular targets that lie within the membrane bilayer. The hydrophobic phospholipid bilayer imposes an impenetrable barrier to water-soluble polar therapeutic agents. The [NAME] lab recently developed a computational method, Computed Helical Anti-Membrane Protein (CHAMP), to rationally design peptide probes that recognize protein transmembrane domains with high affinity and selectivity. This study utilizes this cutting edge technology to study the activation mechanism of oncogenic Latent Membrane Protein 1 (LMP-1) of [NAME] virus (EBV). EBV is a human tumor virus associated with a number of malignancies and lymphoproliferative syndromes. EBV's ability to infect and immortalize B lymphocytes underlies its contribution to human disease. EBV's transforming activity depends on the expression and activity of LMP-1, the viral oncoprotein expressed in many EBV-dependent lymphomas and lymphoproliferative syndromes. LMP-1 functions as a constitutively active Tumor Necrosis Factor Receptor (TNFR) whose activity requires the function of its hydrophobic transmembrane domain. LMP-1 most resembles the TNFR CD40 in its signaling. Unlike CD40, whose activity requires activation by ligand, LMP-1's activity is constitutive and ligand-independent. Constitutive homo-oligomerization and lipid raft association, activities of LMP-1's transmembrane domain, play a key role in activation of downstream signaling. This proposal focuses on LMP-1 as a model membrane protein target for the design of peptide inhibitors because of LMP-1's essential role in EBV-dependent B cell transformation, LMP-1's contribution to EBV-dependent lymphoma and lymphoproliferative syndromes, and EBV's dependence on LMP-1's hydrophobic transmembrane domain for activity. This study aims to develop an innovative approach to target LMP-1's transmembrane domain, using CHAMP-designed anti-peptide antagonists as probes to study the contribution of oligomerization and raft association to LMP-1 activation, with the goal of inhibiting downstream signaling. Results of this research will provide insight into the molecular interactions within the membrane environment and the mechanisms underlying constitutive/oncogenic receptor signal transduction across membranes, will reveal the mechanism of LMP-1's constitutive activation of signaling, and will be applicable to the future development of novel therapeutics targeting diseases dependent on critical transmembrane proteins. Specifically, this proposal addresses the following Aims: 1) Can anti-TMD-1 peptides probes be developed that have high affinity and specificity for LMP-1's TMD-1? 2) Do identified peptides bind specifically and with affinity to LMP-1's TMD-1 in vitro? and 3) Can peptides that target TMD-1 (identified in Aims 1 and 2) interfere with LMP-1 homo-oligomerization, raft association, and constitutive signaling in intact cells? |  | 0
200930074315053T32GM008759-09S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 128992 | 4934.51 | The goal of this training grant proposal is to prepare gifted predoctoral trainees for productive research careers in the field of signaling and cellular regulation. The training faculty consists of an outstanding, internationally recognized group of inve | [NAME], | 1
200930074315053T32GM065103-08S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 64382 | 0 | This renewal proposal seeks continuing support for the NIH/CU Molecular Biophysics Training Program at the University of Colorado, Boulder. The goal of this 4-year old program is to prepare exceptional, highly motivated biophysics students for productive |  | 0
20093007431505909347G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 685013 | 0 | Rapid changes in the arctic climate system that occurred in the relatively recent past can be compared with the output of climate models to improve the understanding of the processes responsible for nonlinear system change. This study focuses on the transition between the Holocene thermal maximum (HTM) and the onset of Neoglaciation, and on the step-like changes that occurred subsequently during the late [NAME]. The millennial-scale cooling trend that followed the HTM coincides with the decrease in Northern Hemisphere summer insolation driven by slow changes in Earth?s orbit. Despite the nearly linear forcing, the transition from the HTM to the Little Ice Age (1500-1900 AD) was neither gradual nor uniform. To understand how feedbacks and perturbations result in rapid changes, a geographically distributed network of proxy climate records will be used to study the spatial and temporal patterns of change, and to quantify the magnitude of change during these transitions. \n\n\n\nThe researchers of this collaborative project will use lacustrine sediments to produce 13 new high-resolution proxy climate records of the past 8000 years. The study sites form two focus regions (eastern Beringia and the NW Atlantic) that generally coincide with the nodes of the surface temperature expression of the Arctic Oscillation (AO). This effort will nearly double the number of high-resolution lacustrine records that extend through the last two millennia, and will generate some of the first high resolution records that capture the HTM. During the HTM, summer sea-ice cover over the Arctic Ocean was likely the smallest of the present interglacial period; certainly it was less extensive than at any time in the past 100 years, and therefore affords an opportunity to investigate a period of warmth similar to what is projected during the coming century. This study focuses on lakes because lakes are the most widely distributed sources of proxy climate records that consistently extend through the post-glacial interval. \n\n\n\nBecause climate change is amplified in the Arctic, the climate signal preserved in arctic lake sediments should be stronger than elsewhere. The proxy records generated in this project will use conventional and newly emerging techniques to document the spatio-temporal patterns of abrupt environmental changes, and to derive quantitative estimates of past summer temperature and hydroclimate variables. Most lakes have been cored previously and show potential for generating high-quality proxy records. Five of the lakes contain laminated sediment with annually resolved records; others have high sedimentation rates (>0.5 mm yr-1) for sub-decadal resolution across the climate transitions. Confidence in the paleoclimate reconstructions will be bolstered by a multi-proxy approach, and by replicate lake records in each of the focus regions that will be used to distinguish basin-scale thresholds from regional-scale climate shifts. \n\n\n\nThis project builds on on-going climate-modeling experiments that use NCAR?s Climate System Model (CCSM3) to study the sensitivities of the arctic system to volcanism and solar variability. A new data-model comparison proposed for this study will test whether the most prominent changes in the arctic system during the past 8 ka, as reconstructed from the proxy records, can be explained by a plausible combination of system-component conditions coincident with prolonged volcanism. The experiments, conducted with NCAR collaborators, will focus on the elements of the Arctic system (e.g., AO and extent of sea ice) that participate in abrupt transitions, and that might elicit nonlinear changes in the future. |  | 0
20093007431505941405G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 357357 | 0 | Scaling Up is a program of research and development that will enable virtual organizations in the Earth sciences to scale to massive interdisciplinary "communities of communities." A key element is commodity governance, which encodes social and technical aspects of governance in cyberinfrastructure to create virtual units capable of operating, aggregating, and coordinating in a decentralized fashion. This is a deeply integrative effort that synthesizes expertise in the physical sciences, computer science, political science, social science, and software engineering to propose a strategy for governing large-scale Earth science modeling collaborations that are technically, scientifically, and socially complex.\n\n\n\nInvestigators will conduct a sociotechnical study of three interlinked modeling projects in climate, weather, and surface dynamics, and formulate a conceptual framework that addresses the requirements, structures, and policies of virtual organizations in these and similar modeling domains as a basis for commodity governance implementation. Commodity governance units will be implemented on a base of cyberinfrastructure projects that are emerging as a means for expressing modeling activities as end-to-end workflows, accessible through science gateways. The units will be disseminated through the base cyberinfrastructure and demonstrated, to the extent possible, in the target modeling projects. It will be fully utilized in a pilot project focused on the intercomparison of atmospheric dynamical cores.\n\n\n\nThe commoditized governance elements, as their name implies, are expected to be applicable to many modeling virtual organizations, including disciplines such as space weather, ecosystem modeling and fusion. Products of the collaboration will be incorporated into and distributed with the widely used cyberinfrastructure products generated by the Earth System Grid and Earth System Modeling Framework, and introduced to the extent possible into several large virtual organizations. A pilot project that will demonstrate extensive use of tools and concepts introduced by the collaboration will involve graduate students in exemplary processes for model development - the careful, exhaustive analysis of specific components through rigorous collaborative testing. Commodity governance itself is intended to be a powerful democratizing force in the modeling community, as it lowers barriers of entry for smaller and marginalized groups by encouraging accessibility to modeling artifacts and transparent, decentralized decision making processes. The domain in which the proposed work is focusing - the interrelationships of climate, weather, and surface processes - is a key to understanding and addressing critical societal questions about the effects of climate change. |  | 0
20093007431505ANT 0839017G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 533416 | 105451.75 | Researchers from the University of Colorado at Boulder will construct and deploy a number of low powered UV photometers to be placed on long duration stratospheric super pressure (constant volume) balloons to be launched during the joint US-French CONCORD | Post Doctorate | 2
20093007431505ANT 0839020G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 495308 | 11152.88 | The research project will examine the relationship between physical drivers, biogeochemical processes, and microbial community composition in streams in the McMurdo Dry Valleys. The investigators will use molecular phylogenetic techniques, genomic network | Graduate Student, Research Assistant | 3
20093007431505ANT 0839091G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 240000 | 4798.41 | The project is to deploy a field-proven Fe Boltzmann temperature lidar to the U.S. Antarctic station [NAME], and to conduct there multi-year observations pursuing the following scientific objectives: (a) To establish a temperature record throughout the p | Graduate Research Assistant, Professional Research Assistant | 1.5
20093007431505ARC 0856559G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 598504 | 0 | This award supports a field campaign that will expand the Arctic Observing Network (AON) by adding cloud, atmosphere, and precipitation measurements, and associated higher-order data products, to Summit, Greenland, at the top of the Greenland Ice Sheet. T |  | 0
20093007431505ARC 0856634G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 1968016 | 2492.45 | This award supports the continued development of the Exchange for Local Observations and Knowledge of the Arctic (ELOKA). It provides data management and user support to facilitate the collection, preservation, exchange, and use of local observations and |  | 0
20093007431505ARC 0901962G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 862974 | 244.52 | The Arctic system is strongly defined by its seasonality. The extreme annual cycle of solar radiation, interactions between the Arctic and lower latitudes, within-Arctic interactions between the land, ocean, and atmosphere, and the energetics of freeze an |  | 0
20093007431505ARC 0902057G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 114868 | 0 | The primary goal of this project is to investigate the mechanisms underlying the seasonal response of the climate system to Arctic sea ice loss within the context of anthropogenic climate change. This research will utilize the NCAR Community Climate Syste |  | 0
20093007431505ARC 0902134G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 566517 | 0 | This project is an interdisciplinary effort to systematically document, model, and interpret key linkages between physical, biological and human systems in the context of changing seasonality (phenology) due to global and local climate change. In line wit |  | 0
20093007431505ARC 0903024G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 305887 | 364 | Proxies in continuous deep-sea sedimentary archives document slow cooling through much of the Cenozoic until a threshold was crossed leading to the onset of Northern Hemisphere continental glaciation ca. 2.8 Ma ago. Glacial cyclicity followed the obliquit | Investigator, Graduate Student, Research Assistant | 4.3
20093007431505ARC 0909497G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 150000 | 5077.89 | On March 24, 1989, the tanker vessel Exxon Valdez ran aground on Bligh Reef, a well-marked navigational hazard in the Valdez Arm of Prince William Sound (PWS), Alaska spilling 11 million gallons of crude oil into the surrounding ecosytem. In various ways, | Investigator, Research Assistant | 0.7
20093007431505ARC 0909503G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 100000 | 0 | Recent changes in the flow dynamics and overall geometry of the Greenland Ice Sheet have been concurrent with increased surface melting: the velocity of some outlet glaciers has increased, the ice sheet margins have thinned, and the overall mass of the ic |  | 0
20093007431505ARC 0941442G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 576514 | 0 | The goal of most climate research is to detect change over time. Much of the data are in the form of spatiallyarranged remote sensing data or model output. These data sets are voluminous and tend to be organized as separate geo-referenced files for a sing |  | 0
20093007431505AST 0907872G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 500000 | 460.56 | Dr. [NAME] will study the formation and growth of the most massive black holes in the cosmos. These are the powerhouses for the luminous active nuclei that are found at the centers of luminous galaxies. The black holes must grow rapidly, since luminous |  | 0
20093007431505AST 0908621G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 72000 | 6248.01 | The award is for a pilot program to explore two areas related to OH masers: an OH maser survey of the [NAME] galaxy (M 31) to study the dark matter distribution and kinematics in the Local Group, and an OH megamaser survey at redshift ~1 close to the p | [NAME], | 1
20093007431505ATM 0849976G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 99621 | 0 | This collaborative team plans to investigate the evolution of interplanetary coronal mass ejections (ICMEs) at large distances from the Sun. They expect to identify the reasons that existing models do not accurately describe this ICME evolution. With this |  | 0
20093007431505ATM 0852329G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 410736 | 48829.96 | The El Ni'o-Southern Oscillation (ENSO) corresponds to a sloshing of water in the equatorial upper Pacific: during an ENSO cycle water moves back and forth north to south and east to west. This suggests that the time-mean effects of ENSO are to homogenize | Investigator, [NAME], | 2
20093007431505ATM 0856007G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 1587712 | 0 | This project is creating a carefully validated global model that addresses how sea salt from the oceans, soil dust from major deserts, and smoke particles from natural fires enter the atmosphere, are transported and then impact the climate. The work makes | [NAME], | 1
20093007431505ATM 0902813G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 154025 | 13891.33 | A major objective of the Geospace Environment Modeling (GEM) Focus Group on Space Radiation Climatology is to investigate the relationships between interplanetary conditions and trapped radiation belt particles and how these relationships change on long t | [NAME], | 2
20093007431505ATM 0903179G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 574785 | 0 | This project aims to better delineate the global manifestations of non-migrating tides from the stratosphere through the thermosphere and to better determine the origin of the non-migrating tides which is largely in the troposphere. The investigation of t |  | 0
20093007431505ATM 0904139G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 208582 | 0 | This collaborative investigation into the forest atmosphere photochemistry will apply a unique set of collaborative approaches, focused on the chemistry occurring in the near-canopy environment. It is now well known that forests emit biogenic volatile org |  | 0
20093007431505ATM 0933997G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 52051 | 188.59 | The Investigator will develop a simple, effective, and inexpensive method of obtaining very high-vertical-resolution atmospheric measurements made in close proximity to the SOUSY radar beam in [NAME] (a NSF Upper Atmospheric Facilities funded cent | Investigator, | 0.16
20093007431505BCS 0847722G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 490780 | 0 | Under what conditions do people become environmentalists? What causes translocal and transnational efforts to protect biodiversity to be adopted and connected with local interests? What are the implications of trends in global conservation practice toward |  | 0
20093007431505BCS 0847872G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 432046 | 14445.25 | This collaborative project outlines a series of studies investigating the role of individual differences in executive functions (EFs) in expression of implicit racial bias. Executive functions refer to higher-order control processes that regulate thought | Research Assistant | 1.29
20093007431505CBET 0853554G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 280000 | 413.31 | The proposed research will provide new fundamental insights into the transport and rejection behavior of solutes through uniform pores on the sub-1-nm size regime (i.e., the realm of individual small molecules). Currently, very little is known or experime | Graduate Research Assistant , PostDoctoral Researcher | 2
20093007431505CBET 0854510G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 339089 | 60787.98 | Acid Mine Drainage (AMD) is a serious environmental problem resulting from oxidation reactions in sulfidic rock, which is mediated by iron-oxidizing bacteria (IOB). The principal objective of this proposal is to develop a fundamental quantitative understa | Investigator, Post Doctorate, [NAME], | 1.5
20093007431505CBET 0854527G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 350000 | 0 | The multidisciplinary research team assembled for this proposal will apply an integrated chemical, biological, and hydrological approach in field and laboratory studies to investigate the relationships between nutrient loading, endocrine-disrupting compou |  | 0
20093007431505CBET 0854542G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 178291 | 0 | This research program addresses the fundamental science of jet and vortex propulsion by Cephalopods (squid, cuttlefish, etc) and [NAME] (Jellyfish) in contrast to more well-investigated aquatic locomotion through body and fin undulations like most fish. W | [NAME], | 2
20093007431505CBET 0930940G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 295100 | 1368.8 | [NAME]: Metamaterials are a new class of nano/bio related materials which possess unique optical properties derived from the structural design of the constituents rather than their individual chemistry. The PIs propose to use an integrated app | [NAME], | 0.5
20093007431505CBET 0933828G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 275233 | 24218.87 | The formation of crosslinked thermosetting polymers is ubiquitous in our society in applications such as coatings, adhesives, composite materials, dental materials and rapid prototyping. Unfortunately, the same crosslinked structure that is the origin of | Graduate Research Assistants | 2
20093007431505CHE 0848663G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 1200000 | 19904.26 | The Analytical and Surface Chemistry (ASC) Program of the Division of Chemistry and the Solid State and Material chemistry (SSMC) Program of the Division of Material Research (DMR) supports the highly synergistic collaborative research project of Profs. J | Graduate Research Assistant | 1
20093007431505CMMI 0900607G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 249998 | 13372.88 | Recycling concrete aggregates from demolished infrastructure is becoming an important research topic for sustainable development of the construction industry in the U.S. and the world. To addresses this issue, the objective of the present research is to i | Research Assistant | 1
20093007431505CMMI 0928159G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 495093 | 2451.2 | The U.S. is currently pursuing technologies to improve the energy efficiency of buildings. One approach, which is the focus of this research, involves embedding geothermal heat exchange systems within deep foundations to gain improved energy efficiency of |  | 0
20093007431505CNS 0905418G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 125024 | 0 | Parallel, distributed, and Internet-based computing, communication, and information systems are heterogeneous mixtures of machines and networks. They frequently experience degraded performance due to uncertainties, such as unexpected machine failures, cha |  | 0
20093007431505DBI 0930344G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 75763 | 1286.4 | The second part of the 20th century was notable for the development of earth observation systems providing an unparalleled view of a changing world. In the 21st century, a new frontier is real time monitoring biological systems and how those systems are c | [NAME], | 0.25
20093007431505DEB 0918938G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 497774 | 3973.09 | Although the distribution of every species is limited to a particular range, the fundamental ecological processes that determine species' range boundaries are not understood well enough to predict how species will respond to environmental change. This pro | [NAME] | 0.5
20093007431505DGE 0946803G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 2000000 | 87500 | Graduate Research Fellowship Program | [NAME], | 16.4
20093007431505DMR 0847685G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 425000 | 0 | This CAREER award will support an integrated research and education program in the field of theoretical biophysics, with interdisciplinary support from the Division of Materials Research, the Division of Molecular and Cellular Biosystems, and the Division |  | 0
20093007431505DMS 0855010G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 805415 | 16407.9 | The vast range of scales occurring in the Earth's climate system\ncannot be explicitly captured in global climate models, even on\nemerging petascale computers. This project will further\nunderstanding of the effects of physics at a scale that is too small\nt | Post Doctorate, [NAME], | 3.5
20093007431505DMS 0905765G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 54417 | 0 | The proposed research will extend the program initiated by the PI in recent work, namely (a) to study topological and enumerative properties of CW subcomplexes of highly symmetric polytopes, (b) to understand the relationships between these polytopal subc |  | 0
20093007431505DMS 0908097G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 86911 | 21238.48 | This project is to investigate the role of convection on dynamic stability of the three-dimensional incompressible Euler and Navier-Stokes equations. The main objective is to show that convection together with incompressibility plays an essential role in | Investigator, | 0.22
20093007431505DMS 0908221G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 248054 | 11193.54 | Many important dynamical processes take place on networks. Examples include epidemic propagation, genetic regulation, synchronization, information propagation, and many more. Often, these dynamical processes have a modifying effect on the network structur | Graduate Student, Research Assistant | 1
20093007431505DMS 0908456G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 90912 | 0 | This project will apply the geometric theory of exterior differential systems and Cartan\\\\\\'s method of equivalence to a variety of problems arising in differential equations. Clelland will continue the study of sub-Finsler geometry, originally introduced |  | 0
20093007431505EAR 0922126G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 265801 | 13253.98 | Glacial erosion is accomplished by quarrying of rock from rough edges of the subglacial bed, and abrasion of rock that smoothes and polishes the bed. Yet there is little quantitative data how rock hardness and the degree of rock fracturing govern quarryin | Post Doctorate, | 1
20093007431505EAR 0922235G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 282710 | 12557.6 | Erosion of bedrock in river channels is a fundamental process governing the evolution of landscapes that has not yet been evaluated fully. The rate of this erosion and its location within a river channel depend on a river's energy available to do work on | Research Assistant | 1
20093007431505EAR 0934647G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 579965 | 2309.03 | Continuing climate change poses uncertainties on future water resources. The water cycle encompasses fundamental processes that link various elements of climate and water resources. Holding approximately 30% of Earth's fresh water, groundwater?s enormous | [NAME], | 0.25
20093007431505ECCS 0925636G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 299416 | 0 | The objective of this research is to develop a low-cost non-destructive, non-contact probing method for surface and sub-surface characterization of inhomogeneous materials and devices. New artificial and nano-material development requires fast, low-comple | [NAME], | 0.6
20093007431505EEC 0851849G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 300000 | 16989.41 | This three year REU site program will engage nine undergraduate students each year in hands-on-research in the area of functional materials. In addition, two international participants, from the Technological Institute of Monterrey, will join the student | Investigator, | 0.1
20093007431505EEC 0935209G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 58634 | 0 | This engineering education research award to Tufts University in collaboration with University of Colorado-Boulder and Michigan Technological University will study how service learning activities can best be used to enhance student learning about sustaina |  | 0
20093007431505HRD 0929828G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 173196 | 0 | While the number of women receiving advanced degrees in the geosciences has been rising, the face of scientific leaders in academia remains dominantly male. Through the establishment of infrastructure to support the Earth Science Women's Network (ESWN), t |  | 0
20093007431505IIS 0846024G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 608962 | 22986.9 | The increase in obesity and related chronic illnesses has motivated academic, government, and commercial sectors to address this epidemic. Assistive technology interventions provide an inexpensive method to disseminate information, track health metrics, a | Investigator, [NAME], | 0.6
20093007431505IOS 0919986G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 500000 | 0 | The origin of flowering plants represents one of the most significant evolutionary radiations of plants during the last 475 million years. With over 250,000 extant species, angiosperms are the largest and most diverse group of plants to have evolved. It h |  | 0
20093007431505MCB 0919617G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 895017 | 20244.36 | New enzymes can evolve by recruitment of enzymes that have a promiscuous ability to catalyze a newly needed reaction. This project addresses the early stages of evolution of a new activity using the promiscuous N-acetyl glutamyl phosphate (NAGP) reductase | Post Doctorate, | 2
20093007431505MCB 0919961G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 604327 | 4758.28 | To date, E. coli serves as the only cellular system for which a complete replication fork can be reconstituted from purified proteins. In this project, a highly divergent bacterium, Baccilus subtilis, will be explored to learn what principles established | Research Assistant | 1
20093007431505NNG09HP02CC4200309333 | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 26307665 |  | TOTAL AND SPECTRAL IRRADIANCE SENSOR (TSIS) project.  We will design, build, test, calibrate, and deliver the TSIS instrument to Northrop Grumman Space Technology Corporation for inclusion on the National Polar-Orbiting Operational Environmental Satellite System. | Research Assistants | 6.25
20093007431505OCE 0847605G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 610286 | 393.9 | Warming of the upper Indian Ocean since the 1950s has been detected and shown to have a complex vertical structure: near-surface warming accompanies upper-thermocline cooling in the tropics and weaker warming underneath. Causes for the complex structure a | [NAME] | 1
20093007431505OCE 0849695G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 449984 | 0 | The goal of this research is to determine the role of key biological and physical factors on fertilization rates in broadcast spawning, the reproductive strategy used by many benthic invertebrates. The objectives are to quantify the effect of gamete trait |  | 0
20093007431505OCI 0941405G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 357357 | 0 | Scaling Up is a program of research and development that will enable virtual organizations in the Earth sciences to scale to massive interdisciplinary "communities of communities." A key element is commodity governance, which encodes social and technical |  | 0
20093007431505P033A090748G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 307411 | 307411 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education. |  | 29
20093007431505PHY 0854918G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 210000 | 7753.77 | Advances in laser technology and computing power that have been made in the first few years of the 21st century allow one to enter a fundamentally new regime, where the inner workings of an atom or molecule - that is the complex, correlated dance of elect | Graduate Student, Research Assistant | 1
20093007431505PHY 0855664G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 200000 | 12523.71 | This group project aims to delve into a broad range of problems stemming from the desire to understand gases of ultracold atoms and molecules in full detail, and how to manipulate these gases to engineer systems of interest. Of particular interest will be | [NAME], | 2
20093007431505PHY 0903851G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 184400 | 0 | A theoretical study of magnetic reconnection involving magnetic field approaching and exceeding the quantum critical field of 40 terraGauss is the subject of this award. This is a fundamental plasma physics problem with important applications in high-ener |  | 0
20093007431505PHY 0904017G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 480000 | 3657.5 | The intellectual merit of this work stems from the desire to develop a new approach for scalable, neutral atom based, quantum computation and quantum simulation that exploits the electronic and nuclear degrees of freedom in alkaline-earth atoms. The uniqu | [NAME] | 1
20093007431505SC0001966G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO AT BOULDER | 803090572 | 241380 | 0 | 2005360 - The Center for Momentum Transport and Flow Organization in Plasmas\n\n |  | 0
200930106281700846923G | TRUSTEES OF THE COLORADO SCHOOL OF MINES | COLORADO SCHOOL OF MINES | 804011887 | 404658 | 11575.3 | This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).\n\n\n\nIntellectual Merit: This CAREER proposal integrates research and educational activities in the thematic area of gas-surface dynamics critical to nanoscale control of thin-film growth. The goals of the research program are aligned with the Colorado School of Mines? (CSM) focus on Earth resources, energy, and advanced materials. In particular, the study will concentrate on atomic and molecular layer deposition (ALD/MLD). These deposition techniques operate in alternating cycles of self-limiting, gas-solid surface reactions. Recently, ALD has been used in numerous applications due to its ability to deliver conformal films on large-area substrates with nanometer-scale control over the film?s composition and thickness. To date ALD process development has been largely empirical, and with the exception of a few metal oxides, there have been very few comprehensive studies. While ALD is largely limited to inorganic materials, MLD is an emerging technique to deposit organic films. There is a need to develop a molecular understanding of the heterogeneous chemistry that occurs in ALD/MLD processes, so that they may be developed to their fullest potential. The inherent compatibility of the two processes can be utilized for the formation of advanced inorganic-organic hybrid films. \n\n\n\nIn this research and education project, ALD/MLD processes will be examined taking a fundamental science approach. A combination of state-of-the-art surface and gas-phase diagnostics has been assembled that include in situ surface infrared spectroscopy, x-ray photoelectron spectroscopy, quartz crystal microbalance, spectroscopic ellipsometry, and quadrupole mass spectrometry. The powerful capabilities of this approach are demonstrated through the PI?s recent studies on the ALD of TiO2 using [NAME]. This project will illuminate the molecular pathways critical to ALD/MLD synthesis of metal oxides, functional polymers, and advanced metal films. Work on metal oxides will focus on the application of O3 and O radicals, which have received little attention despite becoming the oxidizers of choice for industrial processes. MLD studies will investigate two novel strategies to overcome key limitations facing organic thin film synthesis: (a) process chemistries that produce no reaction byproducts, and (b) ?smart assembly?, in which the initial reagent produces a masked functionality that is selectively activated using a second reagent. Investigation of metals will focus on the key issue of nucleation, with ruthenium serving as the model compound. The PI will further integrate the insights from these three topical areas to design molecular scaffolds for high density nucleation of ultrathin metal films on pre-functionalized surfaces. \n\n\n\nTransformative Aspects: This study can be potentially transformative as it will reveal the molecular transformations occurring during ALD/MLD processes, which will ultimately lead to novel strategies for film growth. Furthermore, this program will address one of the least understood processes in ALD, which is the initial nucleation of metals on different surfaces. \n\nBroader Impact: An inherent feature of the project is the emphasis on education and its integration with research. Specifically, three interrelated educational goals will be pursued: (a) development and assessment of a new interdisciplinary elective course in thin-film processing; (b) close mentorship and career counseling through research; and (c) participation in outreach programs designed to increase minority student recruitment and retention at the undergraduate level. The project also involves a graduate student exchange program with the Eindhoven University of Technology in The Netherlands, which will facilitate a intellectual and cultural experience for students at both institutions. \n\n\n\nThe project addresses fundamental research issues in a topical area of materials science h | Senior Personnel\n\nGraduate Student | 0.5
200930106281700854343G | TRUSTEES OF THE COLORADO SCHOOL OF MINES | COLORADO SCHOOL OF MINES | 804011887 | 320000 | 0 | The goal of this research is to study how lipophilic chemicals penetrate through the outermost layer of human skin, which is called the stratum corneum. The stratum corneum is a thin (20 to 40 um thick), composite membrane containing layers of flattened, dead skin cells called corneocytes surrounded by lipid (oily) molecules that are also organized into layers. The stratum corneum controls the rate at which many chemicals enter the body through the skin. Chemicals can penetrate the stratum corneum by two different paths: (1) through only the lipid layers, or (2) through the corneocytes and lipid layers in series. The prevailing opinion in the skin literature is that chemical penetration is restricted to the lipid layers alone, although no direct proof for this presently exists. Moreover, most arguments offered to support the claim that transport is through the lipid layers exclusively are equally applicable to the case of permeable corneocytes. The results of this research will provide direct evidence to answer the question: Can chemicals penetrate the stratum corneum through the corneocytes? \n\n\n\nThe model chemical chosen for study, 2-(trifluoromethyl) benzonitrile, was selected to simulate chemicals that can penetrate the skin to produce either therapeutic or toxic effects in humans. The diffusion of this molecule in the stratum corneum will be studied using a method called pulsed-field gradient spin-echo nuclear magnetic resonance (NMR). This method measures translational molecular motion (i.e., diffusion) over short periods of time (i.e., millisecond to seconds). It also provides information about restrictive boundaries over short distances (i.e., 0.1-100 um), which will be used to distinguish diffusion through corneocytes and the lipid layers. Although this method has been used widely to study colloids and solid-state engineered materials, its use in the study of biological membranes has been limited. \n\n\n\nThe new data generated in this project will improve our understanding of chemical permeation mechanisms in the stratum corneum, including how it changes with variations in water content. If diffusion within the corneocytes is shown to be a significant route for the absorption of lipophilic chemicals in human skin, the paradigm of skin science will shift, which will change existing strategies for transdermal drug delivery, treatment of skin diseases, and methods for predicting absorption of toxic chemicals through skin. The scientific challenges of using pulsed-field gradient spin-echo nuclear magnetic resonance to study diffusion in a composite medium like the stratum corneum arise in many other materials, both biological and non-biological, and the techniques used here will be applicable to these systems as well. \n\n\n\nThe proposed studies of diffusion in the stratum corneum will be used to train graduate and undergraduate student researchers in the fundamentals of chemical transport in heterogeneous membranes and in applications of the pulsed-field gradient spin-echo nuclear magnetic resonance technique to materials from either biological or engineered systems that contain multiple phases. Women and other underrepresented minorities will be actively recruited into the project, which is designed to develop strong communication and organizational/management skills through experiences that are uniquely available in a research environment. In collaboration with an existing and successful outreach program at the Colorado School of Mines, the research team will develop educational modules on the topic of barrier membranes for elementary, middle and high school students and teachers. | Post-doctoral researcher | 1
200930106281700854516G | TRUSTEES OF THE COLORADO SCHOOL OF MINES | COLORADO SCHOOL OF MINES | 804011887 | 79608 | 2843.88 | This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). \n\n\n\nIntellectual [NAME]: This project proposes to test the hypothesis that natural tracers measured at temporal resolution similar to water fluxes (i.e., daily or sub-daily) can be used to predict coupling between riverine hydrology, surface water-groundwater mixing, and biogeochemistry. The hypothesis will be tested with high temporal resolution monitoring and measurements of selected solutes. These results will inform and improve conceptual and numerical models of hydrologic, hydrogeologic, and chemical dynamics and fluxes. Hypothesis testing will address three specific science questions: 1) What are the temporal and longitudinal dynamics of surface/groundwater mixing, and how do these affect the delivery of ecologically relevant solutes (nitrate, phosphate, H+, dissolved organic carbon)? 2) How does assimilation of high resolution stream chemistry data into integrated, parallel watershed models (e.g., PARFLOW) improve predictions of stream flow, groundwater elevation, surface/groundwater mixing and solute transport? 3) How does the incorporation of high resolution chemical measurements and mission agency data into Bayesian network models improve real-time predictions of stream flow and surface/groundwater mixing ratios? The work will be focus on the Santa Fe River in North Florida. This river crosses the boundary of the confined and unconfined karstic [NAME], resulting in two chemically well-characterized source water end-members: surface runoff and groundwater. These end members mix in dynamic proportions depending on river discharge. The end members should be able to be discriminated using in situ continuous sensors, primarily for specific conductivity, and high resolution auto-sampling to allow complimentary measurements of color, pH, nitrate, phosphate, and major ion concentrations.\n\n\n\nBroader Impacts: This work will impact the scientific community by contributing to the development of distributed hydrologic sensing capabilities, which is the basis of the WATERS test-bed sites. High resolution sampling techniques and modeling of hydrologic and hydrogeologic dynamics will be tested across sites by interactions with the Baltimore WATERS test-bed site. The sampling will be co-located with existing flow infrastructure (e.g., USGS gaging stations) and results will be combined with agency data to discern where river water comes from, how long it took to get there, and what it carries. This information will be provided to cognizant water management agencies and stakeholder groups to better inform management and policy decisions. The data will be organized in the CUAHSI hydrologic information system for data storage and retrieval, concatenation with mission agency data, and to provide web-based access to archival data. The project will support on-going graduate and undergraduate research. | Graduate students | 0.23
200930106281700855060G | TRUSTEES OF THE COLORADO SCHOOL OF MINES | COLORADO SCHOOL OF MINES | 804011887 | 193628 | 6958.1 | This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).\n\n\n\nNumerous interesting applications have been enabled by embedded sensing technologies and significant research progress on wireless sensor networks. To further ensure a wider adoption of this emerging technology, seamless integration of wireless sensor networks with other existing networks such as [NAME] and the Internet is a must. In order to address challenges that arise from such an integrated infrastructure, this project builds HeteroNet, a heterogeneous networking infrastructure, by augmenting an existing flat and homogeneous sensor network test bed. HeteroNet integrates resource constrained sensor nodes and more powerful sensing devices, stationary nodes, mobile nodes, and resource sufficient servers. These nodes communicate in wireless or wired fashion. This test bed establishes an experimental infrastructure to serve as a platform for development, testing, validation, and evaluation of the investigator's current research on middleware services for emerging applications on hybrid networks.\n\n\n\nResearch benefiting from HeteroNet includes: integration of interoperable sensor networks to the Internet, amorphous event monitoring in sensor networks, and system status monitoring for QoS-aware mobile applications.\n\nHeteroNet enables research that is not possible via simulation or current small homogeneous sensor network test bed. The findings from the research enabled by HeteroNet have a profound impact on pushing the state-of-the-art of next-generation distributed systems and networks. The development of HeteroNet also benefits educational activities at the graduate and undergraduate levels. HeteroNet is used to facilitate and improve courses on networking, distributed systems, multimedia systems, and computer architectures at the graduate and undergraduate levels. The test bed is open to other research groups on campus to enable many as yet unforeseen CISE-relevant projects, stimulating more fruitful interactions among different researchers. | [NAME] | 0.08
200930106281700855680G | TRUSTEES OF THE COLORADO SCHOOL OF MINES | COLORADO SCHOOL OF MINES | 804011887 | 510000 | 40167.59 | This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).\n\n\n\nIt will support the CSM group to work on the Pierre Auger Observatory (PAO) [NAME] experiment. The high-energy cumulative exposure of the PAO has surpassed the summed exposures of all previous cosmic ray experiments. First measurements of the energy spectra, anisotropy and particle composition indicate that the observatory has an unprecedented view of the high-energy universe and particle physics at energies well beyond that of the Large [NAME] in Geneva, Switzerland. The observatory combines the collecting power of 1600 surface detectors (SD), the calorimetric energy measurement of a four-eye atmospheric fluorescence detector (FD), and the precision of two laser "test-beam" facilities near the array center. With this baseline configuration completed in late 2008, the observatory will collect data using its full complement of instrumentation. The CSM group has the responsibility for generating the critical hourly data base of atmospheric transmission constants, and overseeing the operation and data processing of these laser facilities. The sensitivity and the observation of anisotropy strongly motivate the need for a precise energy standard. \n\n\n\nFor the past few years, the CSM group has been engaged in outreach activities in southeastern Colorado. Cosmic-ray educational experiments built at CSM were made available for public events and use in classrooms. Recently, two demonstration surface detectors, identical to the detectors at the southern [NAME], were installed in two towns in southeastern Colorado. This installation was part of a continuing effort to enhance science education in this area. CSM undergraduates are naturally involved in the research, as they are required to complete a senior design project as part of their curriculum. | Senior Personnel\n\nGraduate Student\n\nUndergraduate Hourly student | 2.53
200930106281700903457G | TRUSTEES OF THE COLORADO SCHOOL OF MINES | COLORADO SCHOOL OF MINES | 804011887 | 352676 | 0 | This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This project will create and support an open source computer code for entangled quantum many-body dynamics called Time-Evolving Block Decimation (TEBD). Such open source efforts have had a tremendous impact on the solution of complex quantum problems; for example, when density functional theory (an important, now standard numerical solution method in quantum mechanics, quite different in aim and scope than TEBD), became open source, it led to a rapid development of advanced materials for renewable energy and other sectors of key national interest. TEBD uses entanglement as a convergence parameter to yield a huge advantage in solving quantum problems such as design of nano-systems in reduced dimensions. A goal of this research is to massively parallelize this method for use on the NSF-supported high performance computing (HPC) cluster at the Colorado School of Mines. The specific application focuses on ultracold heteronuclear polar molecules in optical lattices and simulations of these systems to aid experiments designed to explore their use for quantum computing.\n\n\n\nSeveral undergraduate researchers will be trained in HPC and quantum many body theory, with the goal of co-authoring publications on ultracold molecules. This will be done through CSM's senior thesis program, through summer REUs, and through the joint 5 year Engineering Physics BS / Mathematical and Computational Sciences MS program at CSM. Graduate student diversity will be increased through explicit recruiting programs in Africa and South America, as well as of Hispanic-Americans in the US. The award supports graduate students. | Graduate students | 1.67
200930106281700905513G | TRUSTEES OF THE COLORADO SCHOOL OF MINES | COLORADO SCHOOL OF MINES | 804011887 | 150000 | 0 | This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).\n\n\n\nThere is a growing need for wireless networks that can sustain high data rates, are robust to interference, make efficient use of battery resources, and offer secure communications. This project introduces cooperative beamforming (CB), a novel technique that enables high throughput and power efficient communications in a secure manner. CB consists of two stages. In the first stage, the sources share their data with neighboring nodes via low-power communications. Various approaches for such information sharing are considered, with a goal to minimize queuing delays, conserve energy, and achieve high throughput. In the second stage, the cooperative nodes apply a weight to the signal received during first stage, and transmit. The weights are such that a specific objective criterion (e.g., signal to interference at the destination) is maximized. In CB, although each node uses low power, all nodes together can deliver high power to a faraway destination. This increase in power offsets power reduction due to propagation attenuation. CB can be viewed as an alternative to multihop transmission and, unlike multihop transmission, does not deplete the power resources of other nodes. Since CB can achieve long distance communication, new paths can be found to improve the overall network performance. Also, CB improves network security by avoiding eavesdroppers; unlike traditional cryptographic-based protocols that operate at higher layers and are sensitive to the broadcast nature of the transmission medium, CB improves security at the physical layer. CB will be implemented on a hardware network testbed to demonstrate how the developed techniques can revolutionize wireless communications. |  | 0
200930106281700911734G | TRUSTEES OF THE COLORADO SCHOOL OF MINES | COLORADO SCHOOL OF MINES | 804011887 | 228306 | 0 | INTELLECTUAL MERITS. The extraction of melts from the lower crust and their subsequent emplacement at higher structural levels is possibly the most important crustal differentiation mechanism. A significant control on the trace element composition of melts generated in the crust and the residues left behind, hence the distribution of important trace and heat producing elements in the continental crust, is the melting behavior of key trace element-bearing minerals. However, the physico-chemical behavior of these accessory minerals during melting, melt segregation, and melt extraction remains to be quantified.\n\nUsing a natural laboratory approach this project will target metasedimentary and leucogneiss samples from two high-grade migmatite terrains in Prydz Bay, east Antarctica, where excellent exposures preserve evidence for in situ partial melting and melt mobilization. The study will determine where, when and how accessory minerals grow and decompose during key partial melting reactions and, using trace element signatures and equilibrium partitioning criteria, establish the reaction relationships that exist between accessory and major minerals involved in the process of melt generation and extraction. Trace element budgets determined by texturally constrained micro-analysis of the key trace element bearing major and accessory minerals will be integrated with P-T modeling of reaction and melting histories to predict where major periods of mineral growth and breakdown will occur in P-T space. Research results will provide a robust means with which to directly characterize the reaction processes and involvement of key accessory minerals that control liberation and retention of trace elements in the continental crust. An improved understanding of accessory mineral behavior in melts will be used to refine forward model mineral dissolution and growth during anatexis to ultimately predict trace element fluxes in different P-T or tectonic settings. Research outcomes will likely improve our understanding the behavior of dateable accessory and major minerals during high-temperature crustal events, leading to better understanding of the significance of radiometric ages with respect to tectonic processes and crustal evolution.\n\n\n\nBROADER IMPACTS. Central to this research is student participation. A significant component will be completed by PhD candidate Ms. [NAME], a promising young female scientist who will not only gain training in cutting edge analytical geochemistry in first class facilities, but interact with and learn from world leaders in microanalysis. Coupled with integrated thermodynamic modeling, and mentoring of two undergraduate students, this project provides a unique opportunity and important step in Ms. [NAME]' academic career. The two undergraduate positions will provide practical training in applied geochemistry, preparing these students for a future career in academic or applied geoscience, or other industrial applications such as ceramics or crystal optics. In addition, analytical collaborations will establish closer ties with two national laboratories - including the development of synergies for further local USGS support for student research - and allow development of approaches to in situ microanalysis for trace elements and isotopes. |  | 0
200930106281700914852G | TRUSTEES OF THE COLORADO SCHOOL OF MINES | COLORADO SCHOOL OF MINES | 804011887 | 253981 | 0 | This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).\n\n\n\nThe investigator and her colleagues consider a novel high order adaptive semi-Lagrangian approach for kinetic plasma simulations. The major challenge of kinetic simulations is the huge computational cost, from the high dimensionality (3-D in physical space and 3-D in phase\n\nspace) and from the spatial and temporal multi-scale features of the problem. To address these challenges, the proposed methodology consists of three advanced numerical techniques: 1) a conservative semi-Lagrangian method with high order weighted essentially non-oscillatory (WENO) reconstructions; 2) a high order Strang split spectral deferred correction method to bridge time scales of different species and integrate in time with high order accuracy; 3) mesh adaptivity by incorporating the Strang split Semi-Lagrangian WENO method into the framework of adaptive mesh refinement. As a result of high order accuracy and adaptivity in both space and time, the investigator and her collaborators hope to apply the algorithm in realistic plasma applications with affordable computational cost by using relatively coarse and dynamically adaptive mesh. The eventual goal is to enable large-scale parallel simulations in order to predict/confirm/explain the physical phenomenon observed in a broad range of applications.\n\n\n\nThe investigator and her collaborators aim at developing robust and highly efficient numerical algorithms. The well-developed algorithm will have a direct impact in plasma applications, such as developing fusion energy, the modeling of magnetosphere, among many others. Besides, there is large room for further extensions and applications. The algorithm can be extended to solve the more general [NAME] equation. It can served as a microscopic solver in a mix kinetic-hydrodynamic model via the heterogeneous multi-scale method. While designed for the plasma simulations, the proposed algorithm can be further extended to astrophysics applications, semi-conductor device simulations among many others. The broader impact comes from the multi-disciplinary nature of the proposed research. The proposed research will initiate and serve as a solid foundation for collaborative research work with applied mathematicians, plasma physicists and astrophysicists. The collaborative work will not only expedite the development of the research in both sides of collaborations, but also help training graduate students with a diverse background and multidisciplinary skills. | Senior personnel | 0.67
200930106281700923537G | TRUSTEES OF THE COLORADO SCHOOL OF MINES | COLORADO SCHOOL OF MINES | 804011887 | 551296 | 0 | This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).\n\n\n\nWith this award from the Major Research Instrumentation (MRI) program, [NAME] and colleagues [NAME], [NAME], [NAME] and [NAME] from the Colorado School of Mines (CSM) will acquire a 500 MHz NMR spectrometer for use with liquids, a pulsed-field diffusion probe and a new console to upgrade a 400 MHz spectrometer for solids. The suite of instruments will support research targeted towards renewable/alternative energy and materials such as 1) hydrogen fuel cells, 2) synthesis and characterization of organic compounds and polymers, 3) studies of gas hydrates, 4) polymer modified nanostructures to use in electronic devices, 5) mechanistic pathways of chemical transport in membranes, and 6) preparation of plastics from bio-components. It is noted that the instrumentation will be available to faculty members in Chemistry and Chemical Engineering and that there will be collaborative research and educational projects with higher educational institutions and national laboratories in the Denver Metro Region, including the University of Colorado at Denver, Red Rocks Community College, Metropolitan State College of Denver, and the National Renewable Energy Laboratory.\n\n\n\nNuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solutions and in solids. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in chemistry, materials research and renewable/alternative energy. These instruments will be an integral part of teaching as well as research. | Not started | 0
200930106281700931748G | TRUSTEES OF THE COLORADO SCHOOL OF MINES | COLORADO SCHOOL OF MINES | 804011887 | 1406023 | 18850.1 | This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).\n\n\n\nThe objective of this research is the development of methods for the control of energy flow in buildings, as enabled by cyber infrastructure. The approach is inherently interdisciplinary, bringing together electrical and mechanical engineers alongside computer scientists to advance the state of the art in simulation, design, specification and control of buildings with multiple forms of energy systems, including generation and storage. A significant novelty of this project lies in a fundamental view of a building as a set of overlapping, interacting networks. These networks include the thermal network of the physical building, the energy distribution network, the sensing and control network, as well as the human network, which in the past have been considered only separately. This work thus seeks to develop methods for simulating, optimizing, modeling, and control of complex, heterogeneous networks, with specific application to energy efficient buildings. The advent of maturing distributed and renewable energy sources for on-site cooling, heating, and power production and the concomitant developments in the areas of cyberphysical and microgrid systems present an enormous opportunity to substantially increase energy efficiency and reduce energy-related emissions in the commercial building energy sector. In addition, there is a direct impact of the proposed work in training students with backgrounds in the unique blend of engineering and computer science that is needed for the study of cyber-enabled energy efficient management of structures, as well as planned interactions at the undergraduate and K-12 level. | Graduate students | 0.33
20093010628170P033A090707G | TRUSTEES OF THE COLORADO SCHOOL OF MINES | COLORADO SCHOOL OF MINES | 804011887 | 29631 | 0 | Federal Work Study provides need-based financial aid to students | Part time student employment | 0
20093018058920P033A090708G | COLORADO STATE UNIVERSITY | OFFICE OF FINANCIAL AID | 805230100 | 186130 | 0 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education. |  | 0
20093040705659EAR-0911290G | FORT LEWIS COLLEGE |  | 813013999 | 138818 | 1188.92 | Petrological and Geochemistry Research\n\n | Principal investigator for NSF grant \n\n | 0.16
20093040705659P033A090715G | FORT LEWIS COLLEGE |  | 813013999 | 30004 | 132.81 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education.\n\n | Part time student employment | 1
20093040705899P033A090693G | ADAMS STATE COLLEGE |  | 811022373 | 50528 | 6266.66 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education.\n\n | Part time student employment\n\n | 1
20093040724981P033A090697G | ARAPAHOE COMMUNITY COLLEGE |  | 801609002 | 28665 | 0 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education.\n\n | Part time student employment\n\n | 0
200930410963141P30HL101295-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 527802 | 0 | This P30 application seeks to provide resources to recruit Dr. [NAME] to lead the Molecular Physiology and [NAME] (MPIC) in the Division of Pulmonary Sciences and Critical Care Medicine. The Division is based at the University of CO Denver and |  | 0
200930410963141R01CA112219-01A2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 318686 | 53777.36 | Recent studies revealed that EGFR signaling is not limited by signaling at the cell surface, but rather, allcmponents of the pathway move ithin the cell and may associate with and function in various intracellular compartments.  Activated EGFR is rapidly |  | 0
200930410963141R01DE018899-01A2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 370375 | 47901.13 | The goal of this project is to define the function of the basic helix-loop-helix transcription factor Hand2 during mammalian lower jaw development. Our hypothesis is that Hand2 contributes to the development of most lower jaw structures by establishing a |  | 0
200930410963141R01DK078542-01A2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 782003 | 0 | The overall goal of the SEARCH CVD study is to understand the contribution of metabolic, behavioral and diabetes-specific risk factors to the development of cardiovascular sub-clinical abnormalities in adolescents and young adults with type 1 diabetes, as |  | 0
200930410963141R01HD060882-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 370375 | 4974.33 | \tThe development and patterning of an embryo requires coordinate interactions between different tissue layers at appropriate times for successful outcome.  [NAME], this is driven by a group of conserved signaling molecules, their receptors, and t |  | 0
200930410963141R01LM010120-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 721448 | 37800.96 | The goals of this research are to test hypotheses about protein functional sites by validating high-throughput predictions derived from computational biology techniques. Our approach is to develop a revolutionary system that will automatically mine the [NAME] |  | 0
200930410963141R01NR011051-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 663005 | 90546.81 | Acute respiratory failure is a heterogeneous disorder that results in more than 300,000 Americans requiring admission to an intensive care unit for invasive mechanical ventilatory support each year. Though acute respiratory failure is a pulmonary disorder | Reseach Assistant | 2
200930410963141R01NS061940-01A2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 365915 | 0 | The axon?s growing tip, the nerve growth cone advances by amoeboid locomotion, a process that involves concerted regulation of the actin cytoskeleton and cell adhesion. Growth cone adhesion is not well understood, but recent data indicate that amyloid pre |  | 0
200930410963141R03AI082490-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 76965 | 16710.73 | Gammaherpesviruses cause lifelong infection and are associated with various diseases, particularly in immune deficient hosts.  The human gammaherpesviruses, [NAME] virus (EBV) and [NAME] sarcoma associated virus, are associated with a number of ma | [NAME] | 1
200930410963141R03HD058033-01A1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 76792 | 22555.38 | By early childhood, children who will later develop schizophrenia are already\ndemonstrating many of the deficits that are closely associated with the disease in the adult. This project will answer questions that are at the core of the neurodevelopmental h | Reseach Assistant | 0.34
200930410963141R03HL097009-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 76792 | 5240.41 | Bacterial infection of lung airways underlies some of the main complications of COPD, which impact significantly in disease progression and outcome. Acute exacerbations (AE) represent one of the major contributing factors of morbidity, clinical deteriorat | Reseach Assistant | 1
200930410963141R15GM088960-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 802021702 | 229708 | 0 | Pending |  | 0
200930410963141R21AA017754-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 219604 | 62888.84 | Chronic alcohol abuse has a variety of pathological consequences including damage to liver, brain and other organs. Some of these pathological effects can be attributed to ethanol metabolism. Ethanol is metabolized to acetaldehyde by the alcohol dehydroge | Reseach Assistant | 2
200930410963141R21HL097123-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 189200 | 6415.16 | Functional changes in the ?-adrenergic system play an important role in the pathophysiology of\nheart failure (HF) in adults. Experimental data has extensively defined many of the components\ninvolved in the ?-adrenergic receptor (?-AR) response in HF resul | Reseach Assistant | 1.5
200930410963141R56AI078246-01A1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 383958 | 5873.56 | Natural Killer T (iNKT) cells are a lymphocyte population that has evolved to recognize glycolipid antigens presented by CD1d. Upon recognition of glycolipids, iNKT cells respond within hours, reminiscent of innate rather than adaptive functions. These ce |  | 0
200930410963141R56AI084123-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 657523 | 0 | Despite decades of research, the immunological correlates of protection against HIV-1 infection in humans or SIV infection in nonhuman primates remain poorly understood. In contrast, studies on Friend retrovirus (FV) infection in mice highlighted the impo |  | 0
200930410963141RC1CA145581-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 297808 | 0 | Pending |  | 0
200930410963141RC1CA147371-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 500000 | 0 | Pending |  | 0
200930410963141RC1DE020480-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 446269 | 0 | This application addresses the broad Challenge Area (13) Smart Biomaterials ? Theranostics and the specific [NAME], 13-DE-102: Dental Resin Composites and Caries. With a majority of the more than 100,000 million dental restorative treatments perf |  | 0
200930410963141RC1DE020649-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 435105 | 5796.28 | Oral cancer survival has not improved for the past 20 yrs.  Recently, cancer stem cell (CSC)-based therapies have shown their potential to control cancer recurrence. However, the lack of in vivo models has hindered attempts to identify markers of oral CSC |  | 0
200930410963141RC1EY020361-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 499224 | 0 | Pending |  | 0
200930410963141RC1HL100333-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 499999 | 0 | The application will focus on the development of a phenotypic tool based on flow-based assays that will allow scientists and clinicians to clearly phenotype individuals with bleeding disorders and provide them with an effective instrument that will contri |  | 0
200930410963141RC1HL100849-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 500000 | 0 | This application addresses the Challenge Area 06 of ?Enabling Technologies and Prevention? and the specific Challenge Topic 06-HL-104 of ?enabling technologies involving the development of nanotools for pulmonary medicine, particularly aimed at safer and |  | 0
200930410963141RC1HL101071-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 499926 | 0 | Pending |  | 0
200930410963141RC1LM010513-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 500000 | 0 | Pending |  | 0
200930410963141RC1LM010641-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 802021702 | 311535 | 0 | Adaptation of the ensemble Kalman filter to the data assimilation problem for tracking epidemics. |  | 0
200930410963141RC1MH088623-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 477368 | 0 | This application addresses braod Challenge Area 03:  Biomarker Discovery and Validation and specific Challent Topic, 03-MH-101 "Biomarkers in mental disorders." |  | 0
200930410963141RC1MH088735-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 500000 | 43.18 | Progress in understanding and effectively treating diseases like schizophrenia is dependant on identifying reliable objective measures of disease in readily accessible tissues such as blood.  This proposal will verify and characterize a novel gene express |  | 0
200930410963141RC2CA148394-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 2549415 | 0 | Pending |  | 0
200930410963141RC2MD004738-01G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 809986 | 0 | American Indians and [NAME] (AI/ANs) are at increased risk for Type 2 diabetes when compared to other Americans, a gap that continues to widen. Cardiovascular disease (CVD) has become the number one cause of death among AI/ANs, is now more common |  | 0
200930410963142R01AA013618-06A1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 405833 | 0 | Pending |  | 0
200930410963142R01AG013983-22A2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 382055 | 0 | Pending |  | 0
200930410963142R01CA103618-17G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 281835 | 64568.43 | During the past 25 years, studies in epithelial cancers have defined genetic changes in the tumor cells themselves.  However, it is clear that cancer progression and metastasis requires complex interactions between tumor cells and the surrounding stroma. | Reseach Assistant | 2
200930410963142R01DK042549-19A1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 758518 | 2081.08 | The major intent of this project is to modify and expand a family weight gain prevention program that has previously been shown to be effective.  Our previous America On the Move (AOM) Family Program, which focused on helping families make small changes i | Reseach Assistant | 1.5
200930410963142R01DK060590-06A2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 465410 | 0 | Hepatitis C virus (HCV) is a major health problem affecting approximately 200 million throughout the world. Although new therapies have improved the rates of sustained response, a large proportion of patients (~50%) fail to respond to antiviral treatment |  | 0
200930410963142R01EY017533-04A2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 397828 | 0 | A rate limiting step in the development of therapeutic agents for treating diabetic retinopathy is retinal drug delivery. Although intravitreal injections allow significant drug delivery to the retina, repeated intravitreal injections can lead to endophth |  | 0
200930410963142R01GM061855-09A1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 322438 | 29324.93 | Pending |  | 0
200930410963142R01NS027975-18A2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 364149 | 98950.09 | The vasopressin (VP) neurons of the hypothalamo-neurohypophseal system (HNS) are innervated by numerous afferent pathways including projections from the brainstem and hypothalamus that carry information about two physiologically important parameters that | Post Doctorate and Research Assistant | 2
200930410963142R01NS044129-06A2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 370910 | 10181.3 | The potential role of extracellular proteases, namely the plasminogen activator/ plasminogen (PA/plgn) system in synaptic remodeling in the injured spinal cord of rodents will be the focus of these studies.  The PA/plgn system has been suggested to play a | Investigator and Research Assistant | 0
200930410963142R56AI042189-11G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 341095 | 27874.18 | Poliovirus and related human enteroviruses cause a diverse spectrum of human diseases including acute flaccid paralysis (paralytic poliomyelitis), aseptic meningitis, myocarditis, conjunctivitis and fatal systemic infections of neonates.  Poliovirus (PV), | Post Doctorate | 0
200930410963142R56DK046868-14A1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 187665 | 0 | Goals: The main goals of this proposal are to optimize the isolation of postnatal stem/progenitor cells (pSPCs)\nfrom adult pituitary cells derived from WT, dnEtsZ transgenic, and neuroendocrine-targeted menin [NAME]) mice; to quantitate the number o |  | 0
200930410963143G08LM009639-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 66015 | 1101.75 | There are many reasons to believe that the rate-limiting factor impeding progress on a variety of text mining task types is the lack of availability of the right kind of annotated data--particularly full-text journal articles--for training and testing lan |  | 0
200930410963143K01AA016922-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 36180 | 0 | The general research area of this supplement is\nto study the genetics of alcohol dependence. In particular, genetic\nvariations associated with the alcohol preference phenotype will be\nexamined through the analysis of data from a global gene expression\nstu |  | 0
200930410963143K07CA088811-06S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 54000 | 0 | The research involves development of a web-based system. The software will allow\nclinicians to use a web-based, graphical interface to calculate power and sample size for\nscreening trials. The software will be based on our published methods for power and\n |  | 0
200930410963143K08AI073525-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 50000 | 0 | My goals are to develop sensitive and specific new tools for the rapid diagnosis of the newly discovered human coronaviruses NL63 and HKU1; characterize their prevalence, diversity and clinical spectra; and identify a receptor for RM-BtCoVs.   These studi | No jobs | 0
200930410963143K08AI076518-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 49999 | 0 | Administrative Supplement NOT-OD-09-056 for 5K08AI076518-02 will provide additional funds to increase the speed of data acquisition for the parent grant by obtaining new resources: a professional research assistant and a gel documentation and quantificati | No jobs | 0
200930410963143K08DK067254-05S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 48695 | 5247.54 | T cells leave the circulation and enter lymphoid compartments, where antigens are presented, then recirculate thousands of times, returning to areas with a similar micro-environment to that found where they first recognized their cognate antigen.  To reci | No jobs | 0
200930410963143K08NS053610-04S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 70443 | 0 | Pending | No jobs | 0
200930410963143K22CA113700-03S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 100000 | 0 | This project investigates the role of Wnt 7a in the development of lung cancer. | No jobs | 0
200930410963143K24AI074343-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 50000 | 0 | A primary objective of the K24 grant is to provide mentorship to graduate and medical students, residents, postdoctoral fellows, and junior faculty who are interested in developing careers in patient-oriented, HIV-1 immunology research.  The research proj |  | 0
200930410963143P30CA046934-22S3G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 50000 | 0 | Pending | No jobs | 0
200930410963143P30CA046934-22S4G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 1461788 | 0 | Pending |  | 0
200930410963143P30CA046934-22S5G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 365042 | 0 | Pending |  | 0
200930410963143P30DC004657-09S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 212831 | 24173.77 | The Rocky Mountain Taste and Smell Center (RMTSC) P30 Core provides support services for 8 NIDCD-funded principal investigators studying the chemical senses including taste, smell and chemesthesis.  The core provides Service Cores for studies involving tr | Investigator, Research Assistant, Post Doctorate | 1.8
200930410963143P30DK048520-14S2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 295456 | 22727.85 | CNRU Capital Equipment | Post Doctorate | 1
200930410963143R01AA013973-05S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 133366 | 614.02 | Middle school and high school adolescents are at high risk for drinking alcohol, both experimentally and in more abusive ways, but little is known as to how this process is both initiated as well as perpetuated.  Nonhuman primates living in social groups |  | 0
200930410963143R01AG026529-03S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 82543 | 145 | Pending |  | 0
200930410963143R01AI052164-06S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 314823 | 0 | The overall objective of the project has been to identify the major allergens of peanuts using functional assays combined with the tools of proteomics.  This is important because these studies will identify those peanut allergens that have the greatest ab |  | 0
200930410963143R01AR052263-21S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 35564 | 16821.68 | Epidermolytic hyperkeratosis (EHK, OMIM #144200), also known as bullous congenital ichthyosic erytheroderma (BCIE), is a subtype of ichthyosis that is characterized by dry and scaly skin. EHK is caused by dominant mutations in the keratin 10 (Krt10) or Ke | Reseach Assistant | 3
200930410963143R01AR056292-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 616130 | 0 | Generalized vitiligo is the most common pigmentation disorder, autoimmune death of melanocytes resulting in white patches of skin and hair, and patients are at high risk of other autoimmune diseases such as thyroid disease, adult type 1 diabetes, rheumato | No jobs | 0
200930410963143R01CA087849-08S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 53103 | 13570.1 | Smads are signaling effectors of transforming growth factor beta.  We found that Smad2 and Smad4 expression is frequently reduced in human skin cancer and [NAME]-specific ablation of Smad2 or Smad4 in mice increases susceptibility to chemical skin c |  | 0
200930410963143R01CA100560-05S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 149896 | 0 | SA1 To determine if [NAME]?, RAR?, and PPAR? are necessary and/or sufficient to mediate the growth\ninhibitory effects of retinoids and thiazolidinediones on thyroid carcinoma cell lines.\nThe specific studies in this aim are focused on silencing of [NAME]?, RAR? | No jobs | 0
200930410963143R01CA102514-06S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 349606 | 0 | Pending |  | 0
200930410963143R01DA004216-21S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 68686 | 0 | Pending | No jobs | 0
200930410963143R01DC000566-20S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 65984 | 10098.06 | This proposal describes a 2-yr project in response to the American Recovery and Reinvestment Act of 2009 - NIDCD Administrative Supplement. This project will Accelerate the Science (ACC supplement) by:\n1) adding professional staff to pursue a specific sci | Investigator | 0.38
200930410963143R01DC000766-19S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 60235 | 8834.03 | The three aims of the parent grant are (1) to determine the role of specific receptors in umami taste transduction, (2) to determine the role of downstream signaling effectors in bitter and umami taste transduction, and (3) to determine the role of Type I | Reseach Assistant | 0.8
200930410963143R01DC006070-06A1S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 181924 | 7017.67 | This request seeks funds in accordance with the ?Accelerating the Science? program at NIDCD.  The additional research proposed follows logically from the experiments originally proposed in Aim 3 of the funded proposal and will provide a platform for desig | Investigator and Research Assistant | 0
200930410963143R01DC006865-06S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 51018 | 0 | Obtain equipment to accelerate the science in my lab |  | 0
200930410963143R01DC008297-03S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 160373 | 16461.47 | The goal is to characterize voltage and ligand-gated ion channels in type I hair cells and calyx terminals isolated from early postnatal and adult rodent vestibular system using whole cell patch clamp techniques (Specific Aim 1).  In Specific Aim 2, data |  | 0
200930410963143R01DC008373-03S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 133760 | 0 | In this ACC supplement, I request funds to expand [NAME] of the parent grant which focuses on the role of Wnt/?-catenin signaling in taste bud development, using molecular genetic manipulation of the Wnt/?-catenin signaling pathway. The studies outlined i | Reseach Assistant | 0
200930410963143R01DE012728-12S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 39643 | 0 | AP-2 transcription factors have important roles in many developmental processes and are linked with human birth defects affecting the facial skeleton.  Three of the mouse genes, Tcfap2a, Tcfap2b, and Tcfap2c ? which encode AP-2?, AP-2?, and AP-2?, respect |  | 0
200930410963143R01DE015648-07S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 125676 | 0 | The purpose of the supplement request is to: 1. Purchase a compound microscope and imaging system which will be used in the studies proposed in Aims 1-3 of the parent grant.  Many of our proposed studies, especially in Aims 1-3, require imaging of salivar |  | 0
200930410963143R01DE017699-03S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 53495 | 0 | In order to generate the craniofacial skeleton, neural crest progenitors need to adopt one specific fate verses another. It is the long-term goal of my laboratory to determine the molecular mechanisms that regulate cell fate determination of neural crest |  | 0
200930410963143R01DK052121-15S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 80986 | 0 | Pending |  | 0
200930410963143R01DK062245-05S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 9599 | 0 | (B) Tissue specific deletion of netrin-1 during acute lung injury. We are presently generating a floxed netrin-1 mouse model (see letter [NAME], these mice will be available to us in summer 2009). We will then cross these mice with cre-recombinase mice fo |  | 0
200930410963143R01DK064741-05S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 64158 | 0 | Purpose: To enable completion of breeding and analysis of transgenic mice with targeted loss of vascular\nCREB to test the hypothesis that loss of CREB accelerates progression of atherosclerosis.\nProposed scientific activities and methods:\nSA#1: Analyze th |  | 0
200930410963143R01DK074835-03S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 197612 | 0 | Pending |  | 0
200930410963143R01GM035078-19A1S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 236690 | 0 | The long-term objective of this proposal is to understand the cellular processes that regulate high-fidelity eukaryotic DNA replication. Low fidelity replication and error-prone post-replication DNA repair can result in chromosomal aneuploidy and mutation |  | 0
200930410963143R01GM064475-07S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 291175 | 49018.61 | This administrative supplement will enable us to extend our research to include fundamentally important studies that would otherwise not be performed until the next competitive renewal of the grant.  As such, it will allow us to markedly accelerate the pa | Post Doctorate | 1
200930410963143R01GM080334-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 108622 | 0 | Pending |  | 0
200930410963143R01HD046752-05S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 194788 | 0 | Pending |  | 0
200930410963143R01HL062410-10A2S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 235573 | 0 | Chronic beryllium disease (CBD) is a granulomatous lung disorder that is characterized by the accumulation of beryllium-specific CD4+ T cells in the lung. With the presence of a known antigen and an accessible target organ, CBD is an important model of im |  | 0
200930410963143R01HL083491-04S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 19256 | 8678.72 | Pending | None. | 0
200930410963143R01HL086680-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 272986 | 0 | Pending | None. | 0
200930410963143R01HL086783-01A2S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 333282 | 1448.96 | This project is aimed to investigate molecular mechanisms of pathologic vascular remodeling associated with pulmonary hypertension. The studies will facilitate specific aim 1 of parent [NAME] grant and will include extensive comparative characteristics of VV |  | 0
200930410963143R01HL089049-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 24587 | 24559.98 | Mammals that hibernate depress their metabolic, heart and respiratory rates, as well as their core body temperature (Tb) to enter a state called torpor. In hibernators such as ground squirrels, torpor is precisely controlled and fully reversible using onl | Reseach Assistant | 1.1
200930410963143R01HL089508-01A1S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 18090 | 0 | We have shown that PGIS promoter variants lead to functional differences in mRNA expression.  Because of the rich variety of promoter sequence variants and their close association with a variable number of tandem repeats, direct DNA sequencing has been th |  | 0
200930410963143R01HL090480-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 33880 | 14033.91 | Through funding of the parent grant for this project, histopathological evidence of plexiform lesions of HIV-related pulmonary arterial hypertension (HRPAH)  were identified in the lungs of macaques infected with a chimeric SIV containing the HIV nef gene | Reseach Assistant | 2
200930410963143R01HL092188-01A2S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 320525 | 32749.56 | :Extracellular nucleotides liberated at inflammatory tissue sites are metabolized to adenosine by surface-expressed ecto-nucleotidases (CD73 and CD39). Ongoing studies indicate that adenosine liberated by this process is available to activate surface aden |  | 0
200930410963143R01MH076919-03S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 18670 | 5595.27 | The parent grant is a R01 that funds a randomized controlled trial of the Fostering Healthy Futures preventive intervention for preadolescent children placed in out-of-home care as a result of abuse or neglect.  The intervention is designed to promote chi | Reseach Assistant | 1.5
200930410963143R01MH081177-03S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 301204 | 0 | Genetic linkage and biochemical studies support the investigation of the alpha 7 nicotinic acetylcholine receptor gene (CHRNA7) as a candidate gene in schizophrenia. The alpha7* receptor is the target of nicotine in tobacco, a product used excessively in |  | 0
200930410963143R01NS050138-05S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 76708 | 0 | Gene expression in experimental models of viral encephalitis |  | 0
200930410963143R21AI076161-01A2S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 229875 | 0 | The overall objective of the requested administrative supplement is to accelerate the tempo of research on the parent grant and to stimulate the United States economy as mandated by the Recovery Act by hiring a post-doctoral fellow with the specific skill |  | 0
200930410963143R21HL094921-01A1S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 175085 | 3072.53 | The specific aims of the parent project are to 1) determine the effectiveness of inhibitory RNA mediated purine analog resistance and purine analog treatment (iPAR/PA) in human hematopoietic progenitor cells and 2) determine the toxicity of lentivirus del | Post Doctorate | 1
200930410963143R24AA013162-08S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 913423 | 0 | The Rodent Gene Array Program (R-GAP) will create and continually improve a web-enabled database for analysis of genetic, genomic and phenomic data and eventually proteomic data. |  | 0
200930410963143T15LM009451-03S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 445637 | 15744.09 | Pre- and Post- doctoral training in computational biology | Post Doctorate | 2
200930410963143U01AA016653-04S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 302828 | 0 | The overarching goal of the Integrative Neuroscience Initiative on Alcoholism (INIA)-West Consortium is to identify the molecular, cellular, and behavioral neuroadaptations that occur in the brain reward circuits associated with the extended amygdala and |  | 0
200930410963143U01DK057151-11S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 150293 | 0 | Look AHEAD is randomized clinical trial examining the long-term health effects of an intensive weight loss intervention in approximately 5,145 overweight volunteers with type 2 diabetes. Participants are randomized to an intensive lifestyle intervention d |  | 0
200930410963143U01DK062402-08S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 300816 | 0 | The specific aims of the work to be supported by the requested administrative supplement will accelerate and expand the work plan contemplated under both randomized clinical trials in the HALT PKD network.\n\n1.\tMaintain and retain a large HALT study popula |  | 0
200930410963143U10HD038998-08S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 186131 | 0 | Pending |  | 0
200930410963143U54DE019259-02S1RG | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 13103 | 0 | ARRA Administrative Supplement: Providing Summer Research Experience for Students and Science Educators |  | 0
200930410963143UL1RR025780-02S1G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 557157 | 0 | This application for supplemental funding is in response to NCRR Administrative Supplements for Collaborative Community Engagement Research. The Colorado Clinical and Translational Science Institute (CCTSI) proposes to work with two of its partner communi |  | 0
200930410963143UL1RR025780-02S2G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 399387 | 0 | This NCRR administrative supplement application is in response to "NCRR Administrative Supplements for Enhancing NCRR Pilot Project Mechanism". Collaboration and disciplinary integration are at the heart of the Colorado Pilot and Collaborative Studies (CO |  | 0
200930410963143UL1RR025780-02S3G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 863573 | 0 | Pending |  | 0
200930410963143UL1RR025780-02S4G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 588815 | 0 | Pending |  | 0
200930410963143UL1RR025780-02S5G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 499942 | 0 | Pending |  | 0
20093041096314IOS-0920768G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 802021702 | 55947 | 7350.01 | The major goals of this project are to determine which wavelengths of light induce fluorescence in spiders, to quantify the wavelengths of light emitted, to measure how brightly spiders fluoresce, to map body regions where fluorescence occurs, and to asce |  | 0
20093041096314P033A090747G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 802021702 | 174463 | 169571.04 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education. |  | 16
20093041096314T0AHP15944G | REGENTS OF THE UNIVERSITY OF COLORADO, THE | UNIVERSITY OF COLORADO- DENVER | 800452570 | 29168 | 0 | Scholarships for Disadvantaged Students |  | 0
20093057490187P033A090743G | COLORADO STATE UNIVERSITY-PUEBLO |  | 810014901 | 31469.73 | 24275.67 | Title IV Federal Student Financial Aid - Federal Work Study\n\n | Part Time Student University Employees or Student Employees working in Non-Profit Public Service Position.\n\n | 3
200930734101851R21DA026773G | UNIVERSITY OF NORTHERN COLORADO |  | 806396900 | 198260 | 25998.1 | Injection drug use (IDU) is a major public health problem that is associated with a host of medical complications, including blood-borne viral disease (e.g., HIV, Hepatitis C) and bacterial infections (e.g., skin abscesses, endocarditis) that often result from high-risk drug injection practices. There are no current interventions designed to reduce bacterial infections among injection drug users (IDUs), despite approximately 32% of IDUs reporting a current infection and almost 70% reporting a lifetime prevalence. The objective of this program of research is to reduce high-risk injection practices among active IDUs that lead to bacterial and viral infections by developing and establishing the efficacy of a skin and needle hygiene intervention that combines psychoeducation, skill-building, and motivational interviewing. The long-term objective of this program of research is to develop effective infection prevention programs that incorporate components of the Information-Motivation-Behavioral Skills theoretical model. In the first phase of the study, we will conduct focus group interviews with 24 IDUs in order to determine key areas of emphasis for an intervention with this population. We will then develop an infection-control intervention for active IDUs, pilot the intervention with 5 new participants in an open trial, and elicit their feedback regarding the intervention. Following refinement of the intervention, we will conduct a small randomized controlled trial (n = 60; 30 in each group) to examine the efficacy of the intervention compared to an assessment-only condition. We expect that participants randomized to the intervention will improve skin and needle cleaning behavioral skills and reduce high-risk injection practices for bacterial and viral infections. In addition, we will examine the acceptability and feasibility of the intervention to participants at all phases. This intervention will help to reduce the acquisition of bacterial infections and viral disease among IDUs, thus improving health outcomes for this population and reducing health care costs.\n\n | Faculty Research Summer & AY\n\n | 0.26
20093073410185P033A090752G | UNIVERSITY OF NORTHERN COLORADO |  | 806396900 | 66050 | 66050 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education.\n\n | Part time student employment\n\n | 6
20093075759837P033A090722G | MESA STATE COLLEGE | MESA STATE COLLEGE BOOKSTORE | 815013122 | 38759 | 15237.93 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education.\n\n | Part-time student employment\n\n | 2
20093078342102P033A090713G | PIKES PEAK COMMUNITY COLLEGE FOUNDATION, INC. |  | 809065498 | 63728 | 59261 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education.\n\n | Part time student employment\n\n | 5
2009308949818208SE0020/01G | OTERO JUNIOR COLLEGE FOUNDATION | OTERO JUNIOR COLLEGE | 810503449 | 211791 | 23338.44 | ARRA Funding for Personnel, [NAME], and Training.\n\n | Part-time student employment\n\n | 0.25
20093186192829CNS-0844983G | REGENTS OF THE UNIVERSITY OF COLORADO | COLORADO SPRINGS CAMPUS | 809183733 | 400000 | 0 | CAREER:  Building Resilient Internet Services with Learning and ControlThis CAREER project concentrates on building Internet services that are resilient to challenges with machine learning and control techniques. |  | 0
[NAME] | REGENTS OF THE UNIVERSITY OF COLORADO | COLORADO SPRINGS CAMPUS | 809183733 | 320510 | 9239.28 | REU Site for Artificial Intelligence, Natural Language Processing and Information Retrieval.  Broaden intellectual horizon of participants through exposure to opportunities available.  Utilize a combination of theoretical reading and research with a hands | Two student assistants were hired.  Groups of students will work in close cooperation with the PI and the Co-PI.  The students will work in classroom settings, perform research, write and evaluate sofware. | 0.64
20093186192829DMR-0907614G | REGENTS OF THE UNIVERSITY OF COLORADO | COLORADO SPRINGS CAMPUS | 809183733 | 254691 | 9217.39 | Size and Morphology Dependence of Hamaker Constant for Noble Metal Nanoparticles.  This project will investigate the size and morphology dependence of the Hamaker constant for noble metal nanoparticles. |  | 0
20093186192829ECCS-0922486G | REGENTS OF THE UNIVERSITY OF COLORADO | COLORADO SPRINGS CAMPUS | 809183733 | 415477 | 0 | MRI:  Acquisition of High-Power Energy Storage System Test Equipment.  The objective is to acquire instumentation for a new high-power energy storage system research laboratory facility. |  | 0
20093186192829P033A090749G | REGENTS OF THE UNIVERSITY OF COLORADO | COLORADO SPRINGS CAMPUS | 809183733 | 80053 | 57311.01 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education. |  | 6
200931874065383CO340001G | EDUCATION, COLORADO BOARD OF |  | 802031799 | 1034538 | 0 | Child Nutrition Recovery Act - National School Lunch Program Equipment. | This information was not available at October 7, 2009. | 0
20093187406538S387A090006G | EDUCATION, COLORADO BOARD OF |  | 802031704 | 924815 | 0 | Ensure that each homeless child and youth has equal access to the same free, appropriate public education, including a public preschool education, as other children and youth. |  | 0
2009360089640609-6188-2091G | COLORADO COUNCIL ON THE ARTS |  | 802024725 | 314100 | 88.29 | To support the preservation of jobs that are threatened by declines in philanthropic and other support economic downturn. |  | 0
2009360680535690SE0135/01G | CHILD DEVELOPMENT SERVICE |  | 810503449 | 240875 | 19634.5 | ARRA Funding for Personnel, [NAME], and Training.\n\n | Instructor/Teacher for Early Childhood Education-one located in Trinidad, CO and one in La Junta, CO.  In addition, a teacher mentor to assist with orientation and acclamation of new staff.\n\n | 0.25
200937859796180841602G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 782407 | 28679.79 | This project focuses on advancing understanding of critical issues in atmospheric ice nucleation, one of the most basic processes affecting precipitation and impacting the radiative properties of cold clouds. Incomplete understanding of ice initiation processes in clouds results in large uncertainties in the ability to model clouds and precipitation. Under prior support, the Principal Investigators (PIs) have made advancements in the area of real-time measurement of heterogeneous ice nuclei (IN) and in understanding the role of different aerosol particle types capable of initiating ice formation in the atmosphere. These measurements highlight significant remaining questions. For example, atmospheric studies have emphasized the importance of mineral dust as a significant IN source, but laboratory studies of natural dust particles up to 1 micron in size have shown no evidence for IN activity warmer than about -15 degrees Celsius. The second most prevalent IN composition that has been identified in the atmosphere are carbonaceous particles, but their sources are unresolved. Biological aerosols represent potential sources for primarily carbonaceous IN, but their number concentrations are poorly observed by existing measurement methods. Finally, apparent degradation of IN efficiency in polluted air has been observed but there is little fundamental basis for understanding the impacts of atmospheric processing on IN activation.  The Principal Investigators will use laboratory studies to investigate ice formation by natural dusts at sizes up to 5 microns to quantify the relation between IN activation temperature and mineral dust particle size for different mineralogical types. They also will quantify the changes in IN activation properties after exposure to realistic degrees of atmospheric processing. Examinations of supermicron-sized particles as ice nuclei in the PIs` continuous flow ice nuclei instrument is made possible by application of a new particle phase-discrimination detector (PPD) that identifies ice crystals and aerosol particles by their spatial scattering patterns rather than optical size alone. Use of the PPD will permit exploration of the impact of evaporation of IN containing droplets on ice nucleation, of interest due to inferences that this process spawns primary or secondary ice nucleation. The PIs will investigate the number concentrations of biological ice nuclei through studies that utilize a real-time IN detector and application of real-time mass spectrometric or post-application of microbiological methods (DNA analyses) on activated and collected IN. Using this approach, IN-active bacteria are identified at specific temperature and humidity conditions, enabling an assessment of their role across the full temperature regime of tropospheric clouds. After refining procedures through laboratory studies, The PIs will apply these methods to quantify the proportion of ambient IN, as a function of temperature, that are of biological origin. The opportunity also exists to identify heretofore unrecognized biological IN.  The complete abstract for this award is available in Research.gov at: www.research.gov . | .5 FTE Research Faculty; 1.0 FTE Postdoctoral Fellow | 1.5
200937859796180844213G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 454993 | 0 | Absolute ages for the deposition of sedimentary rocks can be determined by radiometric dating of organic material in carbon-rich shales, using the decay of rhenium (Re) to osmium (Os). In particular, fossils of organic-walled graptolites are commonly found in sufficient abundance for direct dating by Re-Os. Historically, correlation of sedimentary units across broad geographic space has relied on comparison of fossil assemblages to establish relative age (biostratigraphy). Most ages based on radiometric dating could only bracket the time of deposition by dating older or younger units. PIs propose that Re-Os dating of graptolites will provide accurate and precise ages at a resolution equal to biostratigraphy, but with the untapped advantage of pinning absolute time. Absolute ages for fossils in the geologic record will fix the time of geologic stage boundaries and graptolite biozones. In addition, increased resolution in the time scale greatly improves the definition of rates for a host of processes, including sedimentation, sea-level change, [NAME], and vertical and horizontal motion of lithospheric plates. PIs have assembled a diverse, cross-disciplinary team with expertise in Re-Os geochronology, sedimentology and stratigraphy of mud-rich systems, graptolite taxonomy and paleoecology, and tectonics. PIs will place time pins in the graptolite-rich Early and Middle Ordovician sedimentary sequence in western Newfoundland to provide solid age control in a critical interval of the Ordovician system with few currently available absolute ages. Moreover, these same graptolite assemblages are found on several other continents, opening the potential for defining temporal variations in the rate of biologic evolution in different geographic realms.Further development of this geochronologic tool and demonstration of its applicability under varied conditions is of immediate interest to the petroleum industry. Re-Os geochemistry shows promise as a tracer to link migrated oil with its source rocks, and simultaneously define the time of migration - information highly sought by the industry to refine basin-scale models. |  | 0
200937859796180846133G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 650001 | 47246.52 | Just like any other large social group, the honeybee colony critically relies on an efficient transfer of material and information among individuals. The interaction network which makes this possible is, however, also open to exploitation by pathogens or other harmful agents which can rapidly spread and infect the large number of available hosts, posing a serious challenge for the group. In a honeybee colony, the task based separation of individuals into behaviorally and spatially distinct subsets offers a potential mechanism by which the colony can resist the spread of an infectious pathogen and understanding its details can thus provide important insights into how the organizational structure of a social group can influence the transmission of an infectious disease. The objectives of this project are to understand the interaction network in a honeybee colony in terms of the behavioral and physiological mechanisms at the individual level, how the structural and functional properties of the network contribute to material flow within the colony, and how individual-level physiological and behavioral alterations could change the network structure and alter transmission patterns in response to infections. The project will also use inquiry-based investigations in animal behavior and disease ecology to get K-5 students, especially girls, involved in science and [NAME] teachers motivated to develop science curriculum based on actual hands-on research. The project will widen the career options for undergraduates by involving them in classroom teaching and contributing to their training as scientists and educators. Understanding the influence of social structure on honeybee diseases makes this study timely to address the recent concern about the health of honeybees, a topic of national importance but also important for extending our still incipient knowledge of biological networks in general. | .38 FTE Undergraduate student; .29 FTE [NAME]; .67 FTE Teaching Faculty | 1.34
200937859796180847641G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 413801 | 8981.5 | Polysaccharides provide structural and mechanical properties for tissues and organs, and they have binding domains for proteins such as enzymes, cytokines, growth factors, and other extracellular matrix components. They are therefore excellent candidate materials for introducing both biomechanical and biochemical functionality into materials for applications such as tissue engineering. Their chemical and physical properties are affected by their polyelectrolyte nature which arises from pendent carboxylic acid, amine, and sulfate moieties. These electrostatic interactions dominate such phenomena as self-assembly, protein binding, and interactions at surfaces and interfaces, and can be used to tune the nanostructure and surface properties of polysaccharide-based materials. The overall goal of this work is to develop techniques to tailor the assembly of complex polysaccharide nanostructures. To accomplish this goal, three research objectives will be achieved: (1) Construct a series of synthetic analogs of a biologically derived polysaccharide nanostructure, aggrecan, with tunable architecture, so that the effects of its nanostructure on solution structure and dynamics can be discerned. (2) Tune the nanoscale structure and composition of polysaccharide-based nanoparticles and surface coatings. (3) Develop complex assemblies of polysaccharide nanostructures, and use them to engineer mimics of biological nanostructures based on polysaccharides, such as the aggrecan aggregate. Polyelectrolyte multilayers, polyelectrolyte complex nanoparticles, and electrospun nanofibers will be employed to control the composition and organization of materials in rectangular, spherical, and cylindrical coordinates, respectively. In the third objective, we will develop techniques to combine these three types of nanostructures into more complex assemblies. BROADER IMPACTS: The success of this research program will provide a new understanding of the physical chemistry and nanoscale organization of an important class of biological materials. This will enable the engineering design of materials that mimic the structure and organization of tissues. The technology developed here will be incorporated into a new course at Colorado State University on the physical chemistry of biomacromolecules, for students in the new interdisciplinary School of Biomedical Engineering at Colorado State University. Participating graduate and undergraduate students will be trained to work at the interface of engineering and biology by applying their engineering expertise to problems in biology and medicine. The PI has established collaborations with researchers in the Colleges of Veterinary Medicine and Agriculture that will give students opportunities to interact with researchers from a variety of disciplines. The PI will develop and deliver a two week summer short course for high school students on polymers that will include daily morning lecture and afternoon laboratory components. The underlying theme for the short course will be that the properties and performance of polymers that they can witness over many length scales and time scales are ultimately related to the molecular architecture. The course will introduce students to polymers beginning with everyday examples and then discuss some of the interesting properties and familiar applications of polymers through topics they can relate to. Polymer production will be introduced through products they are familiar with such as kitchen wrap and disposable plastic kitchenware, polymer solubility will be introduced through discussions of recycling, and polymer solutions and viscoelasticity will be discussed through ?polymers in the kitchen.? Laboratory experiments will be designed that are low-cost and can be easily reproduced in a typical high school classroom. | .46 FTE [NAME] | 0.46
200937859796180847683G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 499984 | 25127.84 | Intensification of hydrologic regimes due to climate change will have important impacts on biogeochemical processes and ecosystem services, but quantifying these impacts experimentally remains a key challenge for earth scientists. My research goal is to investigate the potential impacts of increased precipitation on the interrelationship between biogeochemical cycling of iron and organic matter. In pursuit of this goal, the objectives of this CAREER proposal are to: 1) determine the impact of increasing water content on the iron mineralogy and chemical structure of humic substances along subalpine moisture gradients, 2) Elucidate the role of chemical structure and concentration of humic substances on iron biomineralization along these moisture gradients and in detailed laboratory studies, and 3) Reveal the influence of aqueous geochemistry on the spatial distribution and macromolecular structure of humic substances at the mineral?water interface. The research approach is integrative and will investigate biogeochemical transformations of iron minerals, humic substance structures, and iron organic matter interactions along subalpine moisture gradients at the USDA FS Fraser Experimental Forest in Colorado. In addition, well-characterized iron minerals will be inserted into the soil at multiple depths along the moisture transects to provide more information about the impact of moisture on iron biomineralization pathways under natural conditions. Microbial iron reduction and the spatial distribution, macromolecular structure and chemical composition of humic substances at the iron-water interface will be studied for the first time at the nanometer-scale by scanning transmission X-ray microscopy. My long-term educational goals are to: 1) educate and train future scientists with a tool box of analytical and problem solving skills to address the most complex challenges in environmental biogeochemistry, and 2) to get more woman and minorities interested in the field of Earth sciences. In pursuit of these goals, the objectives of this CAREER proposal are to: 1) Integrate today`s Environmental Biogeochemistry topics into the environmental science curriculum in a real time format, and 2) Launch MEB (Mentoring Environmental Biogeochemistry): an undergraduate research program that brings together multi-disciplinary participants to increase diversity in environmental science and enhance the pipeline for graduate studies. The educational approach is to develop a set of new courses that integrate the need for responsive environmental biogeochemistry topics in the environmental science curriculum and that will be evaluated and assessed professionally. Inquiry-based learning and peer-learning with a laboratory component will be especially valuable for training of scientists in an interdisciplinary field. MEB activities will also specifically address the need for representation of woman and minorities by focusing on topics that have demonstrated to attract underrepresented groups. [NAME]: It is important that we know the impact of climate change on biogeochemical cycling of iron because this could have significant impact on the fate and transport of pollutants and organic carbon. In fact, it was recently concluded that iron minerals are a major control in long-term organic carbon sequestration in soils. The complete abstract for this award is available in Research.gov at: www.research.gov . | .5 FTE Teaching Faculty; .37 FTE Graduate Student | 0.87
200937859796180848845G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 260000 | 4476.34 | This project seeks to develop a novel living and stereoselective anionic polymerization using novel dinuclear ambiphilic silicon catalysts. Building off the recently developed anionic polymerization catalyzed by silylium ions, this project will continue work on the development of new features that will enable this new polymerization system to become an important and versatile technique serving for a wide range of living polymerization reactions and precision polymer synthesis. Such new features include covalently linked dinuclear ambiphilic silicon catalysts for fast propagating rates, asymmetric silicon catalysts for stereoregular polymer synthesis, and efficient processes for converting biorenewable monomers to sustainable polymers. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor [NAME] of the Department of Chemistry at Colorado State University. Professor Chen`s research efforts revolve around the development of new organosilicon chemistry and polymerization catalysis by highly reactive silylium ions. Such chemistry and catalysis will contribute to the discovery and understanding in organic and organometallic chemistry, polymer synthesis, and sustainable chemistry. This research is important in chemical catalysis and polymer synthesis, areas central to the global economy. | .39 FTE Graduate Student | 0.39
200937859796180901770G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 195333 | 16615.8 | The PIs will study higher secant varieties of classically studied varieties such as Segre varieties, Grassmann varieties, and [NAME] varieties. These varieties correspond to parameter spaces for rank one tensors, alternating tensors, and hybrids of regular tensors and symmetric tensors, and their (closed) higher secant varieties correspond to compactifications of the parameter spaces for higher rank tensors. The main goal of the research is the classification of defective secant varieties of Segre varieties, Grassmann varieties and Segre-Veronese varieties. This is analogous to the celebrated theorem of [NAME] and [NAME], which asserts that higher secant varieties of Veronese varieties have the expected dimension (modulo a fully described list of exceptions). This work completed the Waring problem for polynomials which had stood for some time as an outstanding unsolved problem. There is a corresponding, conjectural complete list of defective secant varieties for Segre varieties and for Grassmann varieties. The first component of the project is on the refinement of existing methods and the development of new theoretical and algorithmic methods towards the solution of this classification problem. The second component of the project is concerned with decomposition of tensors. In many applications, it is natural to represent a collection of data as a multi-indexed list. Alternatively, one can think of the data as a multidimensional array (sometimes called a multi-way array). For example, a digital grayscale picture can be stored as a matrix of numbers where each pixel location in the picture corresponds to a location in the matrix and the number in the matrix corresponds to the darkness of the pixel. In a similar manner, a digital color picture can be stored as a three dimensional array of numbers. A mathematical framework that includes the study of multi-way arrays, and their representations as sums of more basic objects, is through parameter spaces of tensors. This project explores problems related to tensors, tensor decomposition, tensor rank and tensor border rank from an algebro-geometric point viewpoint. These subjects have significant applications in fields as diverse as signal processing, data analysis, computational biology, combinatorics, algebraic geometry and statistics. It is the expectation, therefore, that techniques developed through this research will advance our knowledge and understanding across multiple disciplines. | 1.30 FTE Graduate Students | 1.3
200937859796180901806G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 329786 | 5737.57 | The objective of this research is to demonstrate a new table top photolithography scheme capable to print sub-50 nm features. The approach is based on projection holographic lithography, consisting of printing photoresist with the reconstructed image of a computer-designed digital holographic mask. The illumination source is a highly coherent table-top extreme ultraviolet (EUV) laser. The project is significant as it promises to realize a nano-patterning scheme with nano-scale resolution thereby extending laser manufacturing to wavelengths only available until now at large synchrotron facilities. The holography projection lithography approach will allow printing in a matter of seconds patterns with arbitrary motives. Since the pattern smallest feature is mainly determined by the wavelength of the illumination, which for the table top EUV lasers used in this project ranges from 47 to 13 nm, the proposed scheme promises writing resolution in the few tens of nanometers. This project will have a broader impact in education through the training of graduate students in an innovative technology that combines optical engineering and metrology, laser design and material science. The proposed research also will provide exciting learning opportunities for undergraduate students through summer internships organized every year in CSU. The implementation of the proposed nanopatterning scheme will impact other areas of nanoscience and technology, including the development on nano-structured materials, nano-photonics, plasmonic structures, etc.. It promises the realization of a table-top patterning tool with similar capabilities as large synchrotron facilities that could be integrated with other processing tools in a small laboratory environment. | .32 FTE Graduate Student | 0.32
200937859796180901870G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 350000 | 30357 | Coherent nonlinear laser microscopy (CNLM) such as third harmonic (THG) and second harmonic (SHG) generation microscopes are widely used imaging tools. However, their application to date has eluded systems requiring rapid image acquisition. We propose to develop a method for rapidly acquiring three-dimensional (3D) images formed by nonlinear microscopy by means of digital holography coupled with rapid spatio-temporal scanning of the driving ultrafast laser pulses. Intellectual Merits: The proposed research will develop these capabilities which can be used to study fast dynamics of many processes. Making use of recent advances in spatio-temporal focusing, it will be possible to develop new forms of very high speed 3D imaging with coherent nonlinear contrast mechanisms. We will build an understanding of the capabilities of 3D nonlinear imaging and will better understand how to optimize both transverse and longitudinal (axial) resolution, while obtaining 3D information about an object. Broader Impacts: This research will primarily focus on THG microscopy; but the technique is applicable to other coherent nonlinear microscopes, such as second-harmonic generation (SHG) and coherent anti-Stokes Raman spectroscopy (CARS). Increased acquisition rates made possible with holographic microscopy will permit the study of micro- to millisecond-timescale dynamics. Undergraduate researchers will be involved in all aspects of this project focusing on research areas of ultrafast and nonlinear optics, and microscopy. Research findings will be incorporated into courses taught by the PI, particularly Ultrafast Optics and Nonlinear Optics. In addition, the PI will continue revising and delivering his "optics show" for K-2nd graders. | 1.0 FTE Teaching Faculty; .5 FTE Research Faculty; .18 FTE Graduate Student | 2.18
200937859796180902030G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 409117 | 0 | Arctic soils have large stores of carbon (C) and may act as a significant CO2 source with warming. However, the key to understanding tundra soil processes is nitrogen (N), as both plant growth and decomposition are severely N limited. However, current models of tundra ecosystems and their responses to climate change assume that while N limits plant growth, C limits decomposition. In addition, N availability is strongly seasonal with relatively high availability early in the growing season followed by a pronounced crash. There is a need to understand the controls on this seasonality to predict Arctic System responses to climate change, but there are multiple questions that need answers: 1) What causes the seasonal nutrient crash? 2) Does microbial activity switch seasonally between C and N limitation? 3) How will a lengthening of the growing season alter overall ecosystem C and N dynamics, as a result of differential extension of the periods before and after the nutrient crash? 4) What will be the larger impacts of these patterns on the Arctic system? Addressing these questions requires following plant and soil dynamics in a very tight time frame, coupling this understanding of the timing of C and N interactions to an enhanced mechanistic understanding of why the nutrient crash occurs, and then using transect sampling and ecosystem modeling to explore the large-scale implications of this seasonal crash. This proposed research will address our questions by: 1) Varying the length and timing of the growing season in the field by advancing snow melt and warming the ecosystem; 2) Establishing the fine scale seasonal time-courses of soil N availability, plant N content, leaf expansion, root growth and rhizodeposition, ecosystem respiration, microbial biomass and enzyme activity; 3) Conducting lab experiments to determine the extent to which microbial activity is limited by temperature, and C and N availability before and after the crash; 4) Determining how the timing of the nutrient crash and plant growth vary across a latitudinal transect; 5) Refining the Multiple Element Limitation model (MEL) that was developed for arctic ecosystems to better handle how plant and microbial systems respond to N limitation, and incorporating the specific drivers of the crash into MEL; 6) Testing the large-scale spatial and temporal effects of the seasonality of nutrient availability and how it may change in a warming Arctic with a lengthening growing season. This work will require intense mechanistic research focusing on transitions and transformations that occur over only a few weeks at most, but which have profound impacts on the tundra ecosystem. Researchers will scale this mechanistic work to the intermediate spatial scale by conducting transect measurements along a latitudinal transect to validate that patterns that occur locally are robust. They will scale to the whole Arctic system by integrating these mechanisms, and importantly, the N-effects on decomposition, into the [NAME] model that is designed to explore multiple limiting resource effects on ecosystem function. As an integrated package, this research will explore how the changing seasonal pattern that drives the crash in N availability in tundra soils will alter overall tundra C-cycling and its role as a source or sink of C and through this its role in the global climate system. |  | 0
200937859796180905315G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 169990 | 0 | The investigator and his colleagues propose and study a model which can be used to characterize extremes (specifically threshold exceedances) on a regular spatial lattice. A spatial model for threshold exceedance data needs to handle situations where data values exceed the threshold only in limited areas of the study region. The proposed model accomplishes this by creating an overall model composed of many smaller models. The spatial domain is covered by a number of small and overlapping subregions and data on these subregions is modeled with parametric multivariate extreme value models of low dimension. The investigators show that these subregion models can be combined in such a way that the angular measure of the overall model meets the requirements of an extreme value distribution. The idea of constructing an overall model from models of lower dimension is inspired by lattice models from spatial statistics, and the model`s foundation is based on ideas from traditional extreme value theory. Although they occur infrequently, understanding the nature of extreme events is important because of their significant human and economic impact. Recently, there has been much interest in spatial modeling of extremes, particularly in the context of modeling geophysical data such as precipitation. Despite the interest in this area, there still exists a need for extremes models which can describe the dependence in spatial data which are recorded at many locations. The goal of this proposal is to develop and study a model for threshold exceedance data that is recorded on a spatial lattice. While the research in this proposal is motivated by spatial, geophysical data, the methodologies could be utilized in extremes applications well beyond climate science. Because multivariate extremes models for high dimensions are lacking, advancements in this area are significant and are likely to be extended and adapted. |  | 0
200937859796180905399G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 1042470 | 10054.14 | Parallel, distributed, and Internet-based computing, communication, and information systems are heterogeneous mixtures of machines and networks. They frequently experience degraded performance due to uncertainties, such as unexpected machine failures, changes in system workload, or inaccurate estimates of system parameters. It is important for system performance to be robust against uncertainties. What does it mean for a computer system to be ?robust?? How can robustness be described? How does one determine if a claim of robustness is true, or if a system will fail? How can one decide which of two systems is more robust? These are the types of issues we address in this project, with our team of faculty, graduate students, and undergraduate students from Colorado State University and the University of Colorado, and colleagues in industry (DigitalGlobe) and a national laboratory (NCAR, National Center for Atmospheric Research). We are designing models, metrics, mathematical and algorithmic tools, and strategies for (1) deriving system resource management schemes that are robust, and (2) quantifying the probability of meeting performance requirements given uncertainties. We are validating our research by working with DigitalGlobe, which supplies images to Google Maps and Microsoft Virtual Earth, and NCAR, whose research activities include the prediction of severe and catastrophic weather. The robustness concepts being developed have broad applicability, and will significantly contribute to meeting national needs to build and maintain robust information technology infrastructures. | 1.5 FTE [NAME]; .03 FTE Undergraduate Student | 1.53
200937859796180905656G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 180000 | 18410.13 | The PI develops methods in function estimation and inference, using shape-restricted regression splines. The work includes three broad areas in estimation and inference. First, generalized multiple regression models is investigated, where the mean response function is assumed to be smooth and have a shape restriction such as monotone or convex. Second, a new maximum-likelihood method for smoothed unimodal density estimation is developed, that allows for heavy tails such as in the [NAME] family of densities. An application is a new robust regression method that estimates the error density estimation non-parametrically, simultaneously with the regression function. Finally, the proportional hazards model is developed, where the hazard function is assumed to be smooth and have a shape restriction such as monotonicity or convexity.  Many problems in data analysis involve estimation of a function. Standard methods require the specification of the function up to a few parameters, but the a priori knowledge about the function is often vague and qualitative. For example, the researcher might know that a growth curve is smooth, increasing, and concave. The expected number of nesting sites at a lake might be a decreasing function of some pollution measure. Perhaps a hazard rate function is known to be increasing and convex, as in modeling wear-out of a mechanical part, or bath-tub shaped, as in modeling organ transplant failures. Nonparametric methods in function estimation are appealing because they require minimal assumptions, but development of practical inference methods is more difficult. Many methods that assume only smoothness of the function are sensitive to user-defined choices of the smoothing parameters such as bandwidth, number of knots, or penalty parameter, and the user can not rely on inference results that change with these choices. However, when the researcher can also assume a shape such as increasing or convex, the fits to the data become more robust, for the simple reason that the ``wiggling`` associated with over-fitting is obviated. The PI develops inference methods in three important areas: first, generalized regression models, such as when the response is a count or binary. Second, a new method for robust regression is developed, where the error density is assumed to be unimodal and symmetric, to allow for either heavy-tailed or thin-tailed errors. Finally, the proportional hazards model is developed, under shape and smoothness assumptions for the hazard function. These models are often used in medical studies to compare treatments while accounting for possible mitigating factors, and in industry to model mechanical systems. All three of these research projects result in basic data-analysis tools that can be used in virtually any area of science. | 1.0 FTE Teaching Faculty | 1
200937859796180907706G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 324800 | 0 | Reducing the size of a magnetic material down to sub-micrometer or nanometer dimensions changes the energetics of the system and leads to vastly different magnetic landscapes and dynamic excitations that are important for a wide range of present and future technologies. As experimental capabilities for fabricating and investigating structure on the nanoscale continue to improve, there is a wealth of phenomena predicted by numerical models waiting to be explored. This project will explore the magnetization dynamics of magnetic nanostructures. In particular, the project will examine phenomena associated with the dynamics of magnetic vortices and antivortices, as well as, the generation and propagation of spin waves in nanopatterned magnetic systems. Spin waves are propagating disturbances in the ordering of a magnetic material. The project will use combined numerical and experimental investigations to explore and understand these processes. In additional to being of fundamental interest, magnetic nanostructures hold great potential for future information storage applications, non-volatile memory for ?instant-on? computers, and for spintronics applications, that is, for devices that utilize the spin of the electron rather than just its charge, which hold promise for future energy-efficient processing of information. The involvement and training of students at the undergraduate and graduate levels will play a vital role in this research. Students will participate in all aspects of the program, including the construction of new experimental set-ups. The project will also involve an outreach component related to the development of nanoscience and nanomagnetism resources for teachers and the general public. |  | 0
200937859796180909441G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232001 | 771369 | 2592.8 | The goal of this project is to determine how plants, microbes and soil invertebrates interact to drive changes in soil organic matter and carbon sequestration with ambient and increased soil nutrient availability in the dominant upland arctic tundra ecosystem in northern Alaska. The proponents will use a combination of field observation, experimental, laboratory, and modeling approaches to address four research objectives that include: 1. Understanding how well-documented changes in the plant community alter plant inputs to soils (roots and litter)  2. Determining how soil microbial and invertebrate communities respond to these inputs 3. Investigating if the loss of SOM occurs in response to an increase in soil activities and/or a change in community structure, and  4. Developing a model of soil pedogenesis based on the DAYCENT model (Parton et al. 2001) that incorporates the roles of plants, microbes, and invertebrates.  This work will be conducted at the Toolik Lake Long-Term Ecological Research site and will utilize a suite of long-term nutrient-addition plots (some extending back over 30 years) as well as more recently manipulated sites. A postdoctoral researcher, at least two graduate students, and several undergraduates will be trained as part of this project. The PIs will also conduct teacher development workshops and other K-12 outreach programs. | A postdoctoral researcher, at least two graduate students, and several undergraduates will be trained as part of this project. | 0.5
200937859796180914674G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 159601 | 0 | The methods of numerical algebraic geometry extend the reach of algebraic geometry to problems for which existing symbolic methods are not well suited, e.g., due to the number of variables or the inexactness of the coefficients. The value of these methods is continuing to gain recognition. For example, the algebraic geometry software packages [NAME] and CoCoA are both actively developing either new homotopy modules or interfaces to existing numerical software, such as Bertini and PHCpack. Despite the benefits of these numerical methods (e.g., parallelizability), there are a few drawbacks. For example, to find the real isolated solutions of a polynomial system using homotopy methods, one must first produce all complex isolated solutions and then sort out those with imaginary part below a pre-chosen tolerance. Also, one major benefit coming from numerical algebraic geometry is that it is simple to produce approximations of many generic points on any given irreducible component of an algebraic set. However, there is currently no way to recover exact defining equations for the component. This project has two directions. In one, a new set of techniques, based on [NAME] duality and the Khovanskii-Rolle theorem, for finding only the real solutions of polynomial systems will be developed. In the other, the simplicity of finding generic points on algebraic sets via numerical methods will be exploited. The latter direction will include work on recovering exact defining equations via lattice basis reduction techniques such as LLL or PSLQ. Both directions are expected to result in new, freely available software. Polynomial systems of equations are ubiquitous throughout mathematics, science, and engineering. An entire mathematical field - algebraic geometry - grew out of the need to find solutions to these sorts of equations. Until the 1960s, though, there was no known general technique for solving such systems of equations. However, the methods developed at that point require too much memory to be effective except for relatively small problems. More recently developed methods - the numerical methods of Sommese, [NAME], and Wampler, now collectively known as numerical algebraic geometry - allow for the solution of much larger polynomial systems, opening the application of algebraic geometry methods to a wider class of problems. However, there are still drawbacks to these numerical methods. The goals of this project include addressing two of these drawbacks. In particular, the PI will work on developing efficient methods to find only those solutions that are of interest in real-world applications (i.e., real solutions rather than complex solutions) and on recovering valuable exact data from the approximate data that is provided as the output of these powerful new numerical methods. |  | 0
200937859796180915253G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 128366 | 572.17 | The focus of the proposed research is to design, analyze, and implement accurate and efficient numerical methods for flow problems. As is well known, incompressibility and convection-dominance in flow problems pose significant challenges to numerical simulators. In this research project, the PI and his collaborators will develop numerical schemes based on the locally divergence-free (LDF) finite elements and characteristic tracking to overcome the aforementioned two major difficulties. The LDF finite elements have strong potentials for both h-adaptivity (due to the independence of the basis functions to element geometry) and p-adaptivity (due to the hierarchical structure of the basis functions). Discrete Helmholtz decomposition and hybridization will be utilized to decouple resulted discrete linear systems and reduce computational costs. Higher order characteristic methods are developed for long-term simulations with increased accuracy. These new techniques will be incorporated in the discontinuous [NAME] framework to develop fast and robust solvers for [NAME], Navier-Stokes, convection-diffusion-reaction, and magnetohydrodynamics equations.The success of the proposed research will have direct impact on the efficiency and robustness of a large class of numerical simulators for real world problems such as groundwater contamination remediation, intracellular protein trafficking, nuclear waste disposal, oil recovery, weather forecast, and wildfire control. The new mathematical methods and software modules developed in this project will provide reliable tools for a wide range of scientific computing tasks. This project will also provide hands-on training opportunities for graduate students to gain a wide knowledge base and sophisticated skills to apply mathematics and computer simulations to a variety of applications in sciences and engineering. |  | 0
200937859796180916314G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 161545 | 0 | This research program is motivated by the recognition that the volume of sensor data is expected to overwhelm even the enormous performance improvements in silicon technology expressed by [NAME]. The focus is the development of a low-complexity alternative to non-adaptive image formation through innovations in signal design. The objectives support closer monitoring of weather patterns and may lead to a more detailed understanding of climate change. They also impact a wider range of surveillance applications from microwave landing systems to through-wall imaging. The research program is highly interdisciplinary with signal processing as the bridge between application domains and the mathematics of sequence design. Current hardware allows transmission of wavefields that vary across space, polarization, time and frequency and which can be changed in rapid succession. However, sensing resolution is limited, not by hardware, but by the complexity of remote image formation. This research program develops new signal design principles that enable fast and reliable active sensing with minimal receiver signal processing complexity. The basic unit of transmission is a unitary matrix of phase coded waveforms indexed by array element and by pulse repetition interval, where the polarization of constituent waveforms may vary. Golay Complementary waveforms appear as entries of these matrices. Appropriate sequencing of unitary waveform matrices in time eliminates [NAME] induced range sidelobes and provides resilience to multipath without compromising the simplicity of signal processing. OFDM signaling of complementary waveforms improves performance beyond conventional matched filtering by introducing nonlinear signal processing that exchanges static sidelobes for more dynamic cross-terms. The development of a new mathematical framework based on group theory enables the systematic construction of new complementary sequences. |  | 0
200937859796180922142G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 447887 | 42.63 | Surveys represent a key source of data in a wide range of scientific disciplines, and are often an important input in public and corporate decision-making processes. While the primary use of survey data is to describe the population from which the sample was drawn, analysts are increasingly using those data to make inference about statistical models. This use of survey data in model estimation and analysis is referred to as analytic inference for survey data. Survey data producing organizations usually recommend that survey weights be used in all model fitting with survey data, in order to account for the sampling design and the post-sampling adjustments. This often significantly complicates the work of data analysts, in large part because the effect of survey weighting in analytic inference is still incompletely understood. This research will explore some long-standing open issues in analytic inference for surveys. First, within the survey-weighted mode of inference, the PIs will investigate improved variance estimation methods and distributional theory. Second, they will evaluate a number of alternatives to survey weighting in model fitting and inference. This research will advance the state of knowledge in how to properly conduct analytic inference for survey data by bringing together concepts, methods and approaches from survey statistics and other areas of statistics. Ultimately, it will enhance the ability of data analysts to conduct perform analytic inference for survey data. Because of the importance of survey data collection and analysis in so many disciplines, the results of the proposed research will be widely applicable. |  | 0
200937859796180922589G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 30435 | 11653.08 | Wood plays a critical goal in regulating the flow dynamics of headwater streams in mountain areas. The pine beetle is currently making its way across the forests of the Colorado Rocky Mountains and threatens to change the amount and distribution of wood in these stream environments. The speed of beetle infestation and tree die-off makes it imperative to quickly document pre-disturbance conditions in relatively unaffected headwater streams, not least because the recovery times of these streams are likely to be at least a century. The presence of numerous standing dead trees will initially increase wood load to adjacent stream channels, but the lag created by slow forest regrowth will eventually result in substantial decreases in wood load. Creation of baseline inventories of wood loads now, prior to widespread beetle die-off enable an analysis of the effects of forest changes on stream flow and geomorphology. This research will focus on a widespread survey of existing wood loads along undisturbed headwater streams of the Colorado Front Range. Additional objectives are to relate observed variations in wood load to geomorphic and ecological variables and to develop guidelines for use of wood in restoration of streams following timber harvest of beetle-killed trees. Since wood is so important in regulating the environment of headwater streams, stream restoration following timber harvest is likely to include artificial reintroduction of wood to channels. This project will provide needed information about optimal restoration strategies by carrying out a widespread survey of existing wood loads in a range of undisturbed headwater channels during summer 2009. The primary objective is to document wood loads along undisturbed headwater streams of the Colorado Front Range. Additional objectives are to relate observed variations in wood load to geomorphic and ecological variables and to develop guidelines for use of wood in restoration of streams. The project will conduct basic wood surveys along 20 stream reaches, each of which is 10 km in length. The significance of this project includes: development of the first extensive regional database for the semarid Rocky Mountains on spatial variations in wood load within undisturbed headwater streams; education of students; development of guidelines for management and restoration of instream wood; and outreach to the public regarding the effects of beetle kill and timber harvest on headwater streams. | .43 FTE Graduate Student | 0.43
200937859796180923386G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 627326 | 0 | This project, acquiring High [NAME] (HPC) instrumentation, aims to support much larger and more complex problems in science and engineering (especially for data intensive applications), add greater physical fidelity to existing models, facilitate application of HPC to new areas of research and discovery, and support training to attract new researchers. Filling the current void in cyberinfrastructure (CI) resources, the project is expected to change the culture of discovery at the institution, elevating HPC to the level of central infrastructure. Advanced networking will facilitate the interaction of Tier-3 system with other systems, and enhance researchers? abilities to utilize Tiers 1 and 2 systems worldwide. The principal focus of the system will be data- (and often compute-) intensive applications in NSF funded research areas, such as design of extreme ultraviolet lasers, weather forecasting, computational physics, climate change, atmospheric modeling, bioinformatics, network traffic analysis, robotics, computational electromagnetics, remote sensing, robust resource allocation, and magnetic materials. Tier -3 system will expand the domain and range of computations, allowing problems of greater fidelity including multi-physics algorithms and much finer spatial and temporal resolutions. The work is carried out with CSU-Pueblo, a Hispanic-serving institution, as full partner. |  | 0
200937859796180929282G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 270197 | 0 | This project addresses a significant area of uncertainty in our understanding of biogenic sources of gases and aerosols to the atmosphere by updating a 3-dimensional global model (Community Atmospheric Model - Chemistry coupled with Community Land Model). Emissions and processing of several sesquiterpenes will be explicitly simulated and possible new isoprene reaction mechanisms will be considered in the context of secondary organic aerosol formation. These mechanisms have important ramifications for the oxidative capacity of the atmosphere and will help to reduce uncertainties about sources, distributions, and composition of atmospheric organic aerosols. Broader impacts will include traditional student training and course development. An undergraduate will be recruited via the Significant Opportunities in Atmospheric Research and Science (SOARS) program, which provides an opportunity for students of historically underrepresented groups in science to participate in summer research activities. Traditional avenues of peer-reviewed journal articles and conference presentations will enhance scientific understanding. The societal benefit of this work will derive from improved understanding of how the Earth system currently functions and from an improved model framework for simulations of future climate scenarios. |  | 0
2009378597961809-DG-1102-82B1-028G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 4465000 | 9211.36 | Community Wild Fire Protection Plan - IMPLE | .25 FTE Administrative Support | 0.25
2009378597961809-DG-1102-82B1-029G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 6250000 | 12776.9 | Implement wildfire mitigation and forest restoration treatments in high-priority areas of Colorado. | .34 Administrative Support | 0.34
200937859796181DP2OD006450-01G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 1998452 | 0 | The global epidemic of tuberculosis continues unabated. A particularly dangerous family of clinical strains is the "W-Beijing" family, many of which are highly drug resistant [MDR]. The substantial and relatively rapid transmission of these strains across the world has led people to believe that these particular isolates have some capacity or property to resist, and even subvert, the host immune response. Innovative work in the applicant`s research group has uncovered the possibility that at least some of these isolates can induce Foxp3+ regulatory T cells that interfere with the proper expression of protective immunity in the mouse. Moreover, in the highly relevant guinea pig model, the applicant has published new flow cytometric technology to allow [for the very first time] the definition of the host pulmonary immune response. In this second model many of these W-Beijing strains cause extremely severe lung pathology, far worse than that seen using "laboratory strains" of Mycobacterium tuberculosis. This is a very important point, because all new vaccine candidates to date have only been tested against these laboratory strains. In this proposal we will use innovative new [NAME] models to address the role of newly identified T cell subsets in modulating or subverting host immunity to this very serious group of pathogens, using our state of the art level III biosafety facilities. In addition, we will continue to develop innovative new methods to apply these studies to the [currently reagent-limited] guinea pig model. These studies will include three W-Beijing strains that cause a range [moderate to extremely severe] lung pathology [and for which we are submitting a proposal to the NIH to have these three undergo full genomic sequencing], and several characterized examples of drugsensitive/ drug-resistant genetically matched pairs to test the concept that acquisition of drug resistance reduces bacterial fitness, and hence virulence. |  | 0
200937859796181G20RR025863-01G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 478393 | 0 | This proposal outlines a plan for capacity building at the Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University. The RMRBL is one component of the CSU Foothills Campus Infectious Disease Research Center (IDRC). By 2010, the IDRC will provide nearly 25,000 sq. ft of total animal space to serve the needs of over 30 current principal investigators and a dozen collaborative institutions. The IDRC supports research on select agents, emerging pathogens, arboviruses, and mycobacterial diseases at Animal Biosafety Levels 2 and 3, and as such, is a unique facility in the Rocky Mountain region, and nationally. We propose here to increase autoclave capacity at the RMRBL cagewash facility to optimize biosafety and biosecurity sterilization of animal caging and equipment. Installation of a large pass-through autoclave is proposed in an area adjacent to the RMRBL animal facility that will also allow emergency redundancy sterilization in the case of failure of the primary decontaminating autoclave. The size and footprint of the proposed equipment is modeled after a highly functional autoclave located in another cagewash facility on campus, allowing equipment redundancy and proof of concept for the proposed machinery. Funding is also requested for movable animal caging to provide high-level containment housing for species other than mice, and transport housing for animal movement between holding areas and manipulation space. Altogether this proposal will fully equip the IDRC, allowing for projected growth of animal use, and the capacity to efficiently and effectively process equipment needed for specialized research performed at the site. |  | 0
200937859796181R03AI078129-01A1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 73500 | 16486.96 | The emergence of multi-drug resistant (MDR) strains of Mycobacterium tuberculosis has led to a critical need for new therapeutic agents against tuberculosis. M. tuberculosis is endowed with a diverse range of glycosylphosphatidylinositides such as phosphatidylinositol mannosides (PIMs), [NAME] (LM) and [NAME] (LAM), which play an important role in the physiology as well as the immunopathogenesis of mycobacterial infection. Enormous progress has been made in delineating the structure and biosynthesis of PIMs, but until recently the enzymes and steps leading to LM/LAM biosynthesis were not known. The elucidation of the catalytic steps involved in the synthesis of these molecules will help define one of the most complex biosynthetic pathways of mycobacteria in addition to providing new targets for the identification of novel anti-mycobacterial agents. Mutants defective in their synthesis should also enable a precise contribution of these molecules to the immunopathogenesis of tuberculosis. We have recently identified two genes encoding mannosyltransferases responsible for the terminal steps of LM/LAM biosynthesis. In silico analysis of the genetic locale of these genes revealed a possible PIM/LM/LAM biosynthetic gene cluster in the genome of M. tuberculosis. In order to define the PIM/LM/LAM biosynthetic pathways of mycobacteria, we have begun the characterization of genes from this cluster. Thus, the specific aims of this proposal are: 1. Characterization of an acyltransferase by genetic and biochemical approaches; 2. Functional characterization of a protein potentially involved in the transport of PIMs across the plasma membrane. PUBLIC HEALTH RELEVANCE: Identification and characterization of a gene cluster for glycosylphosphatidylinositides of mycobacteria. Dissection of the glycosylphosphatidylinositide (GPI) pathway in mycobacteria will lead to the discovery of a novel class of essential enzymes of M. tuberculosis that may represent new targets for therapeutic intervention. In addition, the mutants defective in some aspects of GPI synthesis will help define the precise role of these molecules in immunopathogenesis. | .03 FTE Teaching Faculty; .62 FTE Research Faculty | 0.65
200937859796181R03DA026490-01G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 73500 | 1182.24 | This present project proposes a quantitative examination of the factors that impact program completion among a population of students in the first campus drug court program in the U.S. called Back on TRAC (BOT). The BOT program addresses a growing need to intervene and treat students whose drug and alcohol use has led to legal troubles, though empirical studies are needed to show its effectiveness among this university population. The specific aims of this current project will include: 1) to systematically examine what factors predict program completion among college students enrolled in the BOT program at CSU; 2) to develop a descriptive profile of students who graduate versus do not graduate from the BOT program; 3) to examine gender differences of BOT clients; and 4) to develop an analytic protocol to continue a large-scale evaluation of all seven BOT sites across the U.S. Based on this protocol, the Principal Investigator (PI) plans to write a future grant application to NIDA to conduct a full evaluation of all seven BOT sites. The PI anticipates applying for an R21 to further this research by examining similar models across all BOT programs. PUBLIC HEALTH RELEVANCE: The current project will be a secondary analysis of the first six years of an innovative program called "Back on TRAC". We will explore what variables at intake predict completion (graduated, withdrew, dismissed) of this first campus drug court substance abuse treatment program. We aim to develop a profile of students who have been successful in the program in terms of demographic variables, substance use history, academic variables, and program variables. | .19 FTE [NAME] | 0.19
200937859796181R21AI080351-01A1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 217351 | 63481.52 | HIV protease is a well established target for the inhibition of viral replication and there are a handful of FDA- approved drugs that are being used to weigh down HIV protease activity. However, these drugs are exclusively targeted to the catalytic site of HIV protease and constant emergence of drug-resistant strains in patients under the therapy underscores the urgent need for the discovery and development of therapeutics with novel mechanisms of action. Here, we seek to explore an unconventional approach that is aimed to interfere with protease maturation, a viral specific autoprocessing reaction responsible for the production of active protease. In the infected cell, HIV protease is initially translated as part of the [NAME]-Pol precursor. This embedded immature protease has intrinsic but very limited activity and the full proteolytic activity is only associated with the mature protease after it is released from the precursor. Extensive research has established that mature protease exists as stable dimers while protease precursors are predominantly monomer, and that precursor dimerization coupled with the cleavages releasing the amino terminus is critical for protease maturation. We recently discovered that changing a positively charged surface residue (H69) to negatively charged amino acids also abolished protease maturation in E. coli and transfected mammalian cells. Therefore, I hypothesize that masking the precursor at regions that are critical for the autoprocessing reaction through the use of high affinity molecules would interfere with protease maturation and inhibit the production of fully active protease. In order to test the feasibility of this concept, we plan to isolate RNA aptamers specific to the protease precursor (Aim 1). Among these, high affinity (Kd < 1 < medicines. anti-HIV novel of development the for maturation protease with interfere to way effective an establish is here goal Our process. this inhibit or block targeted that drug no there Currently, replication. HIV required absolutely enzyme indispensable protease, active production responsible process specific virus a Protease RELEVANCE: HEALTH PUBLIC 2). ([NAME] cells transfected in and vitro aptamers candidate identify evaluated further be will> | 1 FTE Postdoctoral Fellow; .40 FTE Teaching Faculty; .12 Undergraduate Student | 1.52
200937859796181R21AI083856-01G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 211884 | 14987.6 | In the early stages of Mycobacterium tuberculosis ([NAME]) infection, irreversible tissue necrosis occurs as the result of localized lung inflammation. The bactericidal mechanism of macrophages and neutrophils, that are supposed to control the infection, in fact cause lung tissue damage and thus create a microenvironment that favors [NAME] persistence. While [NAME] is primarily an intra- cellular pathogen, we and others have shown that drug-tolerant bacilli can persist extra- cellularly in lesions with necrosis. Our long term goals is to determine whether restoring antioxidant capacity therapeutically will prevent the establishment of persistent, drug-tolerant bacilli thus rendering conventional anti-tuberculosis therapy more effective in animals and humans. Central to our proposal is the use of experimental [NAME] infections in guinea pigs which develop primary lesion necrosis similar to humans with naturally occurring tuberculosis. Our hypothesis is that by restoring therapeutically the antioxidant defenses regulated by the host transcription factor nuclear redox [NAME] (Nrf2) in Mtb-infected guinea pigs, conventional anti-tuberculosis drug therapy will be more effective against persistent, drug-tolerant bacilli. Our preliminary data shows that oxidative stress exists in human and guinea pig [NAME] lesions. These lesions have excessive oxidative stress that depletes systemic and pulmonary antioxidant defenses. Oxidative defenses in the host are regulated, in part, by the transcription factor Nrf2. In human and guinea pig [NAME] lesions, Nrf2 is defective since it fails to translocate from the cytoplasm to the nucleus. As a result, other downstream antioxidant proteins are not expressed in lesions. The aim of this grant is to: Resolve whether Nrf2 targeted antioxidant therapy will increase the efficacy of anti-tuberculosis drugs. We will accomplish this aim by (1) further defining the role of oxidative stress and the depletion of Nrf2- regulated antioxidant defenses in the pathogenesis of lesion necrosis and [NAME] persistence, (2) determining whether antioxidant drugs can restore Nrf2-regulated endogenous antioxidant defenses and (3), determining whether Nrf2 inducing drugs can be used to enhance the effectiveness of current anti-tuberculosis drugs by eliminating the persistence of drug-tolerant bacilli. By better understanding the pathogenesis of [NAME] persistence and drug-tolerance, new treatment strategies can be added to the global fight to control human tuberculosis. PUBLIC HEALTH RELEVANCE: As the body fights the bacterium that causes human tuberculosis, permanent tissue damage occurs, which allows the bacterium to hide and avoid being killed by antimicrobial drugs. Our research is aimed at preventing tissue damage and bacterial persistence so that antibiotics are more effective and the length of time required for patient treatment is reduced. | 1.0 FTE Research Faculty; .10 FTE Teaching Faculty | 1.1
200937859796181R56DK070952-01A2G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 285891 | 9133.38 | The pituitary transcription factor, Pit-1, is responsible for both normal development of the anterior pituitary gland and cell specific expression of three of the pituitary peptide hormones. A clear understanding of the regulation of transcription and cell cycle progression by phosphorylation of Pit-1 will impact not only our understanding of pituitary development and the diseases associated with loss or mutation of Pit-1, but also developmental and disease states associated with other homeodomain transcription factors. | .68 FTE Research Faculty; .12 Undergraduate Student | 0.79
200937859796181RC1AI085992-01G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 500000 | 0 | This application addresses broad Challenge Area (15) Translational Science and specific [NAME], 15-AI-102*: Develop diagnostics and drugs for multiple or extensively drug-resistant tuberculosis (MDR/XDR TB). Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis (TB) in humans, currently infects one-third of the world`s population in its latent form. The emergence of multi-drug- and extremely drug- resistant (MDR/XDR) strains has highlighted the need for new drugs with bactericidal mechanisms different from those of presently available agents and capable of reducing treatment duration. We have identified a series of urea derivatives showing potent bactericidal activity on M. tb in vitro with MICs in the 0.1 1/4M range. These inhibitors appear to be specific to mycobacteria and to show best activity against M. tb, including MDR strains. Preliminary studies on their mode of action indicate that they inhibit in M. tb the synthesis of oxygenated mycolates, trehalose dimycolates (TDM) and phosphatidylinositol mannosides (PIM), all essential components of the mycobacterial cell envelope. These various effects seem to relate, at least in part, to their ability to inhibit in vitro multiple structurally-related ?/?-hydrolase fold enzymes. Their unique effects on the synthesis of mycolic acids and derived lipids suggest that their targets in these pathways differ from those of other anti-TB agents such as isoniazid, ethionamide, thiacetazone and Isoxyl. Likewise, although the importance of PIM in the immunopathogenesis of TB and as essential structural components of the mycobacterial cell envelope has been well documented, to our knowledge, no specific inhibitors of this biosynthetic pathway have yet been identified. Given the important impact of PIM content on the permeability of the cell envelope and susceptibility of M. tb to drugs, we expect inhibitors targeting PIM synthesis to not only be bactericidal to M. tb but also potentiate the effect of other drugs used concomitantly in the treatment of the disease, facilitating their entry inside mycobacterial cells. This could in turn result in the shortening of treatment duration. Based on their potent antimycobacterial activity, novelty of their mode of action and potential to reduce treatment duration, we propose to further develop this family of compounds with the explicit goals of identifying inhibitors efficacious in mice and delineating which aspect of their mode of action accounts for their bactericidal activity. Derivatives of existing products will be synthesized and their MIC/MBC values, toxicity, and bioavailability parameters determined. The most promising compounds, including already synthesized ones, will be tested for efficacy in a mouse model of TB infection. Toward the elucidation of their mode of action, we will assess and compare the macromolecular effects of two prototype urea derivatives on wild-type strains and urea-resistant mutants of M. tb and M. smegmatis that we have isolated. The mutations responsible for conferring urea-resistance in these mutants will be identified and their direct involvement in drug resistance validated using genetic approaches. Finally, in vitro assays will be developed for the most relevant enzymatic targets of this family of inhibitors so as to provide strong bases for the future rational design of optimized compounds. |  | 0
200937859796181RC1GM091424-01G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 324956 | 0 | This application addresses broad Challenge Area (06) Enabling Technologies, and specific Challenge Topic 06-CA-102: Transient Molecular Complexes in Cancer. Virtually all cellular processes, including those involved in cell growth, differentiation, and apoptosis, rely on specific and carefully regulated protein-protein association and dissociation reactions. Dysregulation of these reactions is characteristic and frequently a cause of many human cancers. Because the interactions that underlie protein complexes are often weak and transient, the identification and characterization of critical complexes often has been extremely difficult or unsuccessful. Nowhere has this problem been more evident than with ubiquitin conjugation (E3 ubiquitin ligase) and deubiquitination (DUB) enzymes. Covalent modification of proteins by one or more molecules of the 76-amino acid ubiquitin is the major route of regulated intracellular proteolysis in all eukaryotes, and as such it is responsible for the control of numerous key regulatory proteins. Additionally, depending upon the specific mono or polyubiquitin modification, ubiquitination also can lead to other fates. Thus, ubiquitin signals are used in endocytosis and protein trafficking, transcription activation, kinase activation cascades, and chromatin remodeling. Of the many hundreds of different E3 and DUB enzymes expressed in human cells, physiological substrates are known for only a handful. The transient nature and low-abundance of these enzyme.substrate complexes are among the principal reasons that most attempts to identify substrates by two- hybrid assays or affinity-based pulldown experiments have failed. The goal of this proposal is to overcome these limitations with a new approach termed cognate-complex biotin tagging ("CBiT"). In [NAME], modified biotin ligase and biotin acceptor peptide constructs will be designed to allow biotinylation only when these two components are brought together by interaction of an enzyme (E3 or DUB) with its substrate. By having the biotin acceptor peptide fused to ubiquitin, even transient E.S complexes in vivo will be subject to biotinylation, and only ubiquitin conjugates will be tagged. As a result, bona fide substrates should be highly enriched after affinity-isolation of biotinylated proteins and amenable to identification by mass spectrometry. The CBiT strategy will be tested in vivo in yeast with known E3.substrate and DUB.substrate pairs. In [NAME], cell lines and DNA vectors to implement CBiT will be optimized for efficient application with human E3s and DUBs; several E3s and DUBs that have been implicated in human cancers and other diseases will be used in tests of the CBiT approach. PUBLIC HEALTH RELEVANCE: Aberrant formation or stability of protein complexes is characteristic of many human cancers and other diseases. Because the interactions that underlie protein complexes are often weak and transient, attempts to identify and characterize critical protein interactions frequently are unsuccessful or extremely difficult. To overcome this problem, a new approach termed cognate-complex biotin tagging ("CBiT") will be developed and applied to complexes that regulate ubiquitin-dependent signaling. |  | 0
200937859796181U01AI082164-01G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 979210 | 0 | The long term goal of our program is to develop novel broad spectrum chemotherapeutics that can be used for Phase 1 clinical trials for treating the diseases caused by priority pathogens such as Francisella tularensis, Burkholderia pseudomallei and Yersinia pestis. We have developed a series of high affinity inhibitors of the fatty acid biosynthesis enoyl reductase (Fabl) enzyme that demonstrate in vitro potency against F. tularensis, M. tuberculosis and B. pseudomallei, and are active in an animal model of tularemia, confirming the validity of the target and of our approach. The goal of the present project is to dramatically improve the therapeutic dose by determining how factors such as formulation and modes of delivery, and structural modifications impact the in vivo antibacterial activity of the compounds. Studies will initially focus on the category A pathogen F. tularensis and the tularemia model of infection as this is the system in which we have had the most success. As the project evolves the information gained will be used to drive additional studies on B. pseudomallei and the melioidosis animal model of infection and Y. pestis. We will perform lead optimization studies on the Fabl inhibitors to: (i) improve pharmacology and reduce metabolic liability, (ii) facilitate deliverability/bioavailability, (iii) improve release kinetics, and (iv) assess alternative routes of delivery to optimize candidates for preclinical studies and performing required benchmarks for submission of an IND application. Our goal of developing inhibitors with enhanced in vivo efficacy will be achieved with the following Specific Aims: Aim 1: Effect of formulation and method of delivery on PK and in vivo antibacterial activity. [NAME] of structural modifications to improve PK/PD. [NAME] to Other Priority Pathogens. [NAME] (See instructions): This proposal is to enhance the therapeutic effect of broad spectrum chemotherapeutics with efficacy against F. tularensis and B. pseudomallei and Y. pestis infections. In addition, such chemotherapeutics can be used to treat bacterial agents with significant health relevance, particularly [NAME]-positive pathogens, including MRSA and Gram-negative pathogens including B. cenocepacia, [NAME], and P. aeruginosa |  | 0
200937859796182R01AI046435-09A1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 291358 | 16917.51 | Mosquito-borne viral diseases remain significant causes of morbidity and mortality throughout much of the world and impose tremendous burdens on human and animal care infrastructures. It is critical that we have a better understanding of the molecular basis of vector competence and arbovirus transmission by mosquitoes. Genome sequence information and other bioinformatics are available for three major vector species (Anopheles gambiae, Aedes aegypti and [NAME] pipiens). New techniques are still needed by vector biologists and arbovirologists to fully exploit this explosion of information and develop a more complete understanding of mosquito-borne disease transmission. For the last 15 years, AIDL researchers have been at the forefront developing molecular tools termed alphavirus transducing systems or ATS`s that allow gene expression in a variety of [NAME] (and insect) species. ATS`s have facilitated gene expression in adult mosquitoes, allowed functional analyses of vector and alphavirus genes, and have been used in the study of mosquito-alphavirus interactions. Vector biologists at AIDL, and elsewhere, are currently manipulating innate immune pathways in mosquitoes and need tools such as ATS`s to characterize the effects of these manipulations on arbovirus transmission. Virologists here and at other institutions are testing new antiviral vaccines and drugs in animal models and need tools that facilitate virus exposure of animals by the natural route of infection. We think that ATS`s technology coupled with fluorescent and bioluminescent technology can be an important addition in our arsenal of tools that allow us to observe (in real time) arbovirus transmission. This approach will have an added benefit of reducing the numbers of animals that are needed for transmission and pathogenesis analyses and in evaluating antiviral protection in animals. The specific aims of this grant renewal are as follows: 1) use ATS`s to develop mosquito transmission models for alphaviruses, 2) use these transmission models to understand and improve ATS`s induction of RNA interference (RNAi) in mosquitoes and its impact on transmission, and 3) generate novel [NAME] reporters of alphavirus infection and transmission. PUBLIC HEALTH RELEVANCE Mosquito-borne viral diseases are significant causes of illness and death throughout much of the world. We are only now beginning to understand how virus and mosquito genetics influence vector infection and virus transmission to a host. In this proposal we will develop new alphavirus-based tools to help us understand the effects of these virus and [NAME] genetic factors on infection and transmission. We will develop new methods to track virus transmission from mosquitoes to experimental animals in such a way that the entire transmission cycle may be directly visualized. In this study, we plan to use fluorescent and bioluminescent technology to readily observe and detect alphavirus transmission from mosquitoes to small animals. This grant proposal will use alphavirus transducing systems (ATS`s) to develop vector transmission models, identify specific alphavirus/[NAME] interactions affecting virus transmission, improve ATS`s ability to knock down targeted genes, and develop novel ATS-based biomarkers for mosquito infection. | .08 FTE Teaching Faculty; 1.29 FTE Research Faculty; .43 FTE Graduate Student | 1.8
200937859796182R01CA095056-06A2G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 251891 | 26298.91 | Oncogenesis occurs when mechanisms of cell growth control are deregulated. This generally develops in a multistep process that involves mutations in oncogenes and tumor suppressor genes. The understanding of this process has been greatly enhanced through the study of tumor viruses. The piscine retroviruses and their associated neoplasias are new models of tumorigenesis. Walleye dermal sarcomas (WDS) are etiologically associated with the complex retrovirus, walleye dermal sarcoma virus (WDSV). These sarcomas develop and regress on a seasonal basis, providing a unique model to study molecular mechanisms of tumor development and regression in vertebrates. WDSV expression is highly regulated and the differential expression of viral transcripts correlates with the stage of disease development. Infectious virus is only produced during regression. Our working hypothesis is that the three WDSV accessory proteins, Orf A (rv-cyclin), [NAME], and [NAME], control viral gene expression and function in tumor growth and regression. WDSV rv-cyclin regulates transcription, inhibits virus expression, and enhances cell proliferation. Associations of rv-cyclin with cyclin dependent kinases 3 and 8 (cdk3 and [NAME]), normally bound by host cyclin C, led to the hypothesis that rv-cyclin/cdk complexes alter viral and cellular gene expression and promote cell cycle progression. The long-term objective is to define novel mechanisms of tumor induction and control of gene expression. The proposed research has three specific aims: (1) Characterize rv-cyclin transregulation of transcription. The goals of this aim are to separate and define the mechanisms of rv-cyclin AD and cyclin box transcription control. These studies will focus on p53 and p53-responsive promoters that are regulated by both [NAME] and cyclin C/cdk8 and on NF-kB, which also contacts [NAME], and whose function is clearly inhibited by the rv-cyclin. (2) Define the functional outcome of rv-cyclin/cdk3 interaction. The identification of rv-cyclin-cdk3 interaction suggests a direct mechanism for cell cycle control by pRb phosphorylation. The kinase activity of rv-cyclin/cdk3 will be compared to cyclin C/cdk3, and the specific effects of the rv-cyclin on cell cycle regulation will be determined by flow cytometry. (3) Assess rv-cyclin function in control of virus expression and tumorigenesis. These studies will test wild type and mutated recombinant WDSV viruses with the rv-cyclin gene knocked out, with loss of function mutations in the cyclin box region and in the AD, and gain of function mutation of the AD. The replicative capacity of these infectious viruses will be tested in tissue culture cells and in fish, and the contribution of the rv-cyclin to tumor formation will be assessed. PUBLIC HEALTH RELEVANCE: The proposed research utilizes an efficient animal cancer model that combines tumor formation with natural and complete remission. The causative viral agent encodes a retroviral cyclin that controls cell growth and gene expression. These studies will identify targets for therapeutic intervention of cancer that are fundamental to all higher organisms. | .75 FTE Teaching Faculty; .50 FTE Reasearch Faculty | 1.25
200937859796182R56AI059130-06G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 324264 | 79990.76 | Poliovirus is the best-known member of a large family of viruses that have genomes made of RNA. These viruses carry a gene for a very specific RNA dependent [NAME] polymerase protein that is responsible for replicating the virus genome. The focus of this research project is to understand how this protein works during virus replication and find ways to interfere with its function, which will open the door to the development of antiviral drugs. |  | 0
200937859796183K08AR054903-02S1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 108000 | 0 | proposal is presented for the formal training of a veterinary surgeon in the molecular and genetic aspects of cartilage repair. The candidate is board certified with the American College of Veterinary Medicine, and possesses a Master of Science in Pharmacology and a PhD in Cellular and Molecular Biology. The training proposed in the grant would prepare the candidate for a career as an independent, nationally competitive research scientist. There are two phases in which the training is divided. Phase I will consist of intense training in the development of a gene therapeutic vector and microarray and proteomic analysis as they relate to cartilage repair. As the candidate masters various scientific and laboratory skills in vector development, genomics and proteomics, she will transition to Phase II and carry out the animal studies in a more independent manner while having her mentors available to consult on study design, execution and analysis. Arthritis is the most prevalent disease affecting humans. Despite extensive drug therapy, there is no cure. Growth factors are known to have important biologic effects in intrinsic repair. The aim of the proposed research is to develop a gene therapy protocol for the sustained local release of Insulin-Like Growth Factor-l (IGF-I) in amounts sufficient to promote healing of equine articular cartilage. IGF-I has an important role in cartilage development and homeostasis, and in previous studies has been shown to promote healing in experimentally injured cartilage. An important limitation however has been the inability to sustain therapeutic levels of IGF-I at the site of injury. To overcome this limitation, it is proposed to use an adenoassociated or lentiviral vector to introduce an IGF-I gene construct into equine chondrocytes and synoviocytes. After extensive testing in vitro, genetically modified chondrocytes would be imported into experimentally injured joints, with the resulting repair tissue examined at predetermined intervals. The outlined plan of training and the resources available provide the candidate with an outstanding opportunity to develop expertise and scientific independence in gene therapy approaches to cartilage disease. Lay:Despite extensive drug therapy for arthritis there is no cure. Gene therapy involves the transfer of therapeutic genes (DMA) to improve cartilage repair. This proposal involves the development of Insulin-Like Growth Factor-l gene therapy to improve cartilage health and reduce the incidence of osteoarthritis following cartilage injury. |  | 0
200937859796183R01AI063457-05S1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 150000 | 0 | Public Health Relevance:  Tuberculosis is one of the most important diseases in the world. As recently emphasized by an NIAID document, virtually nothing is known about the host response to, and basic biology of, the rapidly spreading epidemic of MDR strains of this disease, and their potential subversion of these mechanisms. Such information is critical to rational vaccine design. |  | 0
200937859796183R01AI080486-02S1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 99900 | 0 | Chromosomal aberrations figure prominently as the underlying cause of many untoward biological effects caused by exposure to ionizing radiation (IR). These include acute effects responsible for cell and organism death, as well as delayed effects, principally cancers, that arise years post-irradiation. Current technology (e.g., whole chromosome painting) permits adequate detection of most large-scale chromosomal events that occur between different chromosomes, such as translocations. However, in order to advance our understanding of basic mechanisms of radiation injury, there is a need to improve the sensitivity and resolution of detection of smaller scale events, such as the complementary processes of mis-rejoining of DNA double strand breaks (DSBs) that can occur within an arm of a given chromosome, and which lead to either small deletions or inversions. By facilitating an increased understanding of the contribution of these "cryptic" chromosomal changes, the studies proposed here will provide valuable clues into the processes involved in IR-induced injury to the genome and its biological consequences. Such an understanding will ultimately serve to guide the design and timing of possible intervention strategies following accidental exposure or terrorist attack. By facilitating increased detection and understanding of the contribution of "cryptic" intra-chromosomal changes (interstitial deletions and inversions), the studies proposed here will provide valuable clues into the processes involved in ionizing radiation-induced injury to the genome and its biological consequences. Such an understanding will ultimately serve to guide the design and timing of possible intervention strategies following accidental exposure or terrorist attack. |  | 0
200937859796183R01DK037124-21A2S1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 30576 | 5823.51 | The proposed experiments are designed to thoroughly test important aspects of the hypotheses presented in the parent grant. Thus the resulting data should greatly advance understanding of how mRNA stabilization is achieved and how this process mediates the regulation of an essential physiological response of the kidney that contributes greatly to maintenance of normal acid-base balance. | .47 FTE Undergraduate Student | 0.47
200937859796183R01ES012941-05S1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 17137 | 13371.91 | Chronic intoxication with manganese (Mn) is the cause of a degenerative movement disorder, termed manganism, with clinical features that resemble Parkinson`s disease. Recent findings suggest that injury to this region of the brain involves perturbation of the normally supportive function of glial cells to an activated state that results in increased expression of inflammatory genes such as inducible nitric oxide synthase (NOS2), that can subsequently produce neurotoxic levels of nitric oxide (NO). Similar deleterious neuro-glial interactions occur in other degenerative disorders of the basal ganglia, such as Parkinson`s and Huntington`s diseases, highlighting the need to elucidate the mechanisms underlying these damaging interactions. The long-term goal of this research program is to better understand role of glial cells in the pathogenesis of diseases of the basal ganglia. The objective of this application is to identify mechanisms underlying glial-mediated neuronal injury in an experimental model of manganism. The central hypothesis is that Mn exposure results in glial activation and expression of NOS2 that contributes to age-dependent neuronal injury and debilitation of basal ganglia function through overproduction of NO. This hypothesis will be tested by pursuing two specific aims: 1) Determine the Mn-dependent signals that cause induction of NOS2 in astroglial cells. The working hypothesis for this aim is that Mn increases NF-KappaB-dependent expression of NOS2 by activating specific MAP kinases. 2) Identify the mechanisms underlying age-dependent susceptibility of the basal ganglia to manganese. It is postulated under this aim that Mn-mediated production of NO during development results in glial activation and neuronal injury that decreases the threshold for basal ganglia dysfunction upon subsequent exposures. The experimental approach proposed utilizes genetic interdiction of specific signaling molecules in the NF-KappaB pathway to identify critical upstream activators of NOS2 expression in astroglial cells. The activity of the factors identified will be quantified in relation to activity of NF-KappaB and expression of NOS2 in neonatal and adult wildtype and transgenic mice exposed to Mn. It is expected that this innovative approach will identify important early targets of Mn that promote neuronal injury by increased synthesis of NO. The proposed research is significant, because it is expected to advance understanding of the pathogenic role of glial-derived NO in disorders of the basal ganglia and, thereby, to foster the development of neuroprotective therapeutic strategies that target inflammatory signaling pathways in glial cells. | .57 FTE Undergraduate Student | 0.57
200937859796183R01GM072481-12S1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 110250 | 2784.28 | Our overall goal is to elucidate the pathways and mechanisms involved in regulated mRNA stability and post-transcriptional control in general. These processes play a very important role in controlling gene expression related to cell growth and differentiation. Our approach is three-fold. First, we will expand our studies on nucleophosmin, a protein that is deposited on mRNAs as a novel polyadenylation mark, and determine its role in the coordination of gene expression. This work will involve the identification of auxiliary proteins involved in the polyadenylation mark, a determination of the requirements and mechanism of nucleophosmin deposition, the delineation of mRNA targets and a determination of the function(s) of nucleophosmin in post-transcriptional control. Second, we will perform a series of in vivo and in vitro assays to elucidate the full impact of CUG-BP, a regulator of poly(A) tail shortening in human cells, along with its target deadenylase enzyme PARN on the control of gene expression via the modulation of mRNA stability. Finally, we have identified a novel function of for a cytoplasmic [NAME] complex in mRNA stability. The goal of the third aim of this proposal is to determine the underlying mechanism for Lsm-mediated stabilization of targeted mRNAs. In summary, these studies should provide new insights into the mechanisms and regulation of mRNA stability as well as post-transcriptional control in general. Given the impact of RNA biology on cellular growth control, these studies may well provide significant insights into the molecular basis of disease (e.g. cancer, myotonic dystrophy) and possibly improved strategies for molecular therapeutics. |  | 0
200937859796183R01GM084136-01A1S1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 423151 | 0 | Tremendous advances in ion channel research have been made with respect to channel structure and function. However, there is a lack of information regarding how living cells process ion channel proteins in real time. Such information is important since rapid modulation of ion channel surface expression is likely to represent a central mechanism in the regulation of cellular electrical excitability. Human diseases have already been linked to ion channel localization and trafficking defects. The [NAME] delayed-rectifier K+ channel targets to unique cell surface clusters in hippocampal neurons. Since these structures are regulated in vivo by stimuli associated with neuronal injury, i.e. hypoxia, ischemia, and excess neurotransmitter release, these microdomains are likely to participate in the neuro-protective response during such insults. However, [NAME] also plays a role in apoptosis, with this Kv isoform providing the increased K+ permeability required for the completion of the apoptotic program in cortical neurons. These diverse functions mandate that [NAME] activity and trafficking be tightly regulated. Our overall hypothesis is that the [NAME] surface clusters are central in the regulation of both [NAME] trafficking and function. Thus, a better understanding of cluster function will improve our ability to manage stroke-related issues. By clustering these channels within a defined surface compartment that serves as a platform for both insertion and retrieval, the regulation of trafficking is more efficient than if the channel is homogenously distributed over the cell surface. In addition, our preliminary data suggest that channels within the surface clusters do not conduct K+ until released from these cell surface domains, suggesting that K+ current density is controlled by more than transport to the cell surface. The proposed research will employ a multidisciplinary approach utilizing live cell imaging, single channel detection/tracking, site-directed mutagenesis and electrophysiology. The three Specific Aims will test the hypotheses that 1) Kv2.1 clusters represent cell surface platforms for channel insertion and retrieval, 2) stimulus-induced modification of the cortical cytoskeleton causes immediate release from the cell surface cluster and 3) Kv2.1 surface clusters are cell surface storage sites containing non-conducting channel. This research will have implications far beyond neurobiology, for [NAME] is the most widely expressed Kv channel and is also physiologically important to the cardiovascular and endocrine systems.  PUBLIC HEALTH RELEVANCE:  The proposed research examines the localization of the [NAME] potassium channel in brain neurons. This localization is essential in the neuro-protective response to stroke injury and hyperactivity in the brain. Mice lacking the [NAME] channel are epileptic and hyper-excitable. Understanding the molecular mechanisms underlying Kv2.1 localization will enhance the treatment of stroke and epilepsy. |  | 0
200937859796183R01HD009618-30S1 G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 7163 | 5690 | The long-term objective of this work is to understand the molecular mechanisms by which hormones influence uterine smooth muscle contraction and relaxation. This proposal focuses on defining cellular and subcellular mechanisms involved in crosstalk between major contractant and relaxant signaling pathways in the myometrium, in particular the role of scaffolding proteins and compartmentalization of signaling units in these mechanisms. [NAME] will determine the mechanism responsible for the decline in myometrial plasma membrane-associated PKA prior to delivery in the pregnant rat and the relationship of this decline to the regulation of uterine contractile activity by cAMP. We will use a combination of muscle strip, cell culture and whole animal models to study basic mechanism and relate biochemical changes to effects on uterine contractile activity. [NAME] will determine if similar changes in myometrial plasma membrane PKA occur in primate pregnancy in relation to labor. We will examine changes in tissue from both fundus and lower uterine segment in pregnant baboons at different stages in the transition from contractures to contractions and in myometrial tissues from women obtained at the time of cesarean section before or after the onset of labor. Mechanisms of regulation will be explored in vivo and in a pregnant human myometrial cell line. [NAME] will determine the importance of the association of PKA and PP2B with AKAP79/150 in the control of myometrial PLCbeta3 phosphorylation. We will determine the phosphorylation status of PLCbeta3 in response to PKA activation in cells and tissue under conditions where we know Galpha(q) coupling is affected and will explore mechanisms by which PKA can influence activity and membrane association of itself, PP2B subunits and AKAP79/150 in cell culture and pregnant rat myometrial strip models. [NAME] will determine how the constituents of OTR and cAMP regulatory pathways and K(Ca) channels are distributed between plasma membrane microdomains and assess whether distribution is affected by contractant or relaxant signals to influence signaling crosstalk. For these studies we will immunoblot, confocal microscopic immunolocalization and patch clamp methodology. Understanding the mechanisms for the changes in the influence of the cAMP pathway and signaling crosstalk balance will enhance understanding of myometrial activity during pregnancy and labor and may lead to design of improved methods for management of uterine contractile activity and the prevention of premature labor. | Undergraduate Student Laboratory Assistant | 0.2
200937859796183R01HL091905-01A1S1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 152830 | 10067.9 | The luminal diameter of muscular arteries and arterioles of the microcirculation is the principal site of control of vascular resistance. These small blood vessels are significant regulators of blood pressure and local blood flow distribution, and impaired control of their luminal diameter is a major contributor to cardiovascular-related diseases. Vascular smooth muscle cell membrane potential depolarization is central to the actions of vasoconstrictors, including intravascular pressure. Despite considerable investigation, the mechanisms underlying membrane potential depolarization remain obscure. In this proposal, we will examine the novel concept that activation of the melastatin transient receptor potential (TRP) channel TRPM4 in arterial myocytes integrates signals activated by vasoconstrictor stimuli to cause membrane potential depolarization. Evidence is provided that activation of TRPM4 channels causes membrane depolarization, Ca2+ influx via voltage-dependent Ca2+ channels, and vasoconstriction. Thus, TRPM4 appears to be an important mediator of smooth muscle cell depolarization. As such, an increase in TRPM4 activity or channel number could contribute to vascular pathologies such as hypertension, which are characterized by smooth muscle membrane potential depolarization and vasoconstriction. TRPM4 therefore presents an attractive target for drug-discovery efforts, but currently, little is known about how activity of the channel is controlled under physiological conditions. Phospholipase C (PLC), protein kinase C (PKC), and intracellular Ca2+ dynamics contribute to the control of arterial tone in vivo, and are thought to be important regulators of TRPM4. This proposal will address the central hypothesis that these factors elicit vasoconstriction, in part, by modulating the activity of TRPM4. Experiments are proposed that will use patch-clamp electrophysiology and live-cell confocal imaging experiments to elucidate how TRPM4 activity is regulated by PLC and PKC activity in vascular smooth muscle cells (Specific Aim 1), and by dynamic Ca2+ events involving IP3-mediated Ca2+ release from intracellular stores (Specific Aim 2). Specific Aim 3 will extend these studies to the level of the intact vasculature and investigate the role of PLC, PKC, and Ca2+-dependent regulation of TRPM4 in pressure and agonist-induced vasoconstriction. These experiments will utilize intact cerebral arteries for intracellular microelectrode recordings of smooth muscle membrane potential confocal Ca2+ imaging, and simultaneous contractile and Ca2+ imaging studies. Additional experiments will employ siRNA technology to suppress TRPM4 expression in intact blood vessels. The outcome of these experiments will significantly enhance our understanding of the role of TRPM4 in blood pressure and blood flow regulation, findings that will contribute to the development of novel therapies for the treatment of cardiovascular-related diseases. PUBLIC HEALTH RELEVANCE: Experiments described in this proposal will examine how TRPM4, an ion channel protein present in smooth muscle cells that line the walls of blood vessels, controls the diameter of small arteries and arterioles. This is important because these small blood vessels regulate blood flow and pressure, and impaired control of their diameter contributes to cardiovascular-related disease, such as hypertension, stroke, and coronary artery disease. The ultimate goal of this project is to improve human health by stimulating the development of new pharmaceuticals that act through TRPM4 to control and prevent cardiovascular-related diseases. | .5 FTE Graduate Student | 0.5
200937859796183R25RR020469-05S1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 110979 | 40.07 | Program ENERGY`s long-term goal is to reduce the rate of obesity & type 2 diabetes (T2D) in elementary school students by teaching & reinforcing healthy behavior choices. Obesity & T2D are epidemics among our children and effective, feasible, sustainable, outcomes-based prevention in children is needed and MUST be implemented in elementary schools over the next decade. An intervention of this type will protect the health & quality of life of children and, therefore, ensure the nation`s productivity & competitiveness. Research has provided the data & tools necessary to prevent these diseases, but the missing link has been a flexible, successful, research-based prevention program that can be replicated in most US classrooms. Program ENERGY will be developed with the intention of filling this gap & has proven to be a successful & promising model. Our initial program is a science-inquiry learning enrichment program combining 90 min/wk of classroom & physical activity activities designed to prevent obesity & T2D in 2nd - 4thgrade children throughout the school year. Over 2yrs, the intervention had high rates of enrollment & retention and sustained positive evaluations by children, educators & families. It produced significant health outcomes [increased health/science knowledge, attitudes (healthy food selection) and behaviors, (e.g., increased daily steps, increased body acceptance)] compared to the control school. Increased interest in science/health-related careers was also observed. Effective translation of innovative "prevention platforms," like the proposed Program ENERGY, into the elementary schools and into the daily lives of children & their families is a worthy & important goal. Goal of this SEPA combined Phase l/Phase II application, is to combine the most appropriate menu of program elements & resources, & to effectively disseminate the program. The sustainability of Program ENERGY is expected to come from a combination of future program income, sponsorships, & local support. For the present application, the specific aims to address the long-term goals are to develop & evaluate: 1) a major program focus on the prevention of T2D in addition to the prevention of obesity; 2) expand the current program to grades 5 & 6, allowing the ongoing longitudinal evaluation of the effectiveness of the program on BMI, body image, eating & physical activity behaviors, science & math achievement & interest in science and/or health care careers; 3) dissemination of combinations of "stand alone" elements of a mini-Program ENERGY to at least 10 other elementary schools; and 4) dissemination of the full Program ENERGY in 2-4 additional classrooms in low income rural & suburban elementary schools with large Hispanic enrollments. |  | 0
200937859796183U54AI065357-05S1G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 1710939 | 0 | This application proposes to continue the Rocky Mountain Regional Center of Excellence (RMRCE) for Biodefense and Emerging Infectious Diseases Research located in Region VIII. The RMRCE consists of a highly integrated consortium of universities and federal agencies with significant interactions with multiple commercial entities. The RMRCE has completed three years since funding, and for the renewal, plans to build upon the strengths, synergies, and newly developed expertise that have emerged from the past efforts of this program. The renewed research program will be centered around three integrated research focus (IRF) groups that target the thematic research efforts on 1) immunomodulation, adjuvants and vaccines; 2) bacterial therapeutics; and 3) viral therapeutics. The research and product development efforts of the IRF groups will be facilitated by five scientific cores. Research efforts will be directed at a variety of NIH Category A-C pathogens and will exploit the extensive BSL3 facilities within the region so that studies will be performed almost entirely with virulent forms of the pathogens. Training objectives of the RMRCE will include a competitive career development program structured similar to the NIH K-awards and group training efforts for biosafety and product development. The progress of individual projects and cores, as well as the progress and synergy of the overall program will be continually monitored and managed via a robust evaluation process that encompasses input from NIH program personnel, RMRCE leadership from multiple institutions, and external reviewers. Adding to the flexibility of this program will be the continuation of a highly successful program for the funding of Developmental Research Projects. Overall the goals of the RMRCE are summarized as: 1) continue investigator-directed research programs that address basic and translational research for biodefense and emerging infectious diseases, including understudied Select Agents; 2) provide career development and group training that exploits the strengths of the RMRCE; 3) utilize well integrated scientific core facilities to accelerate research and product development activities; 4) enable programmatic flexibility and responsiveness through a strong project evaluation process and continuation of a program for Developmental Research Projects; and 5) establish an emergency response program that is based on the resources of the RMRCE and that is managed by a single individual. |  | 0
20093785979618R01CA085419-10G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 328947 | 131004.98 | The primary focus of this application is to study the total synthesis and biosynthesis of complex, biomedically significant natural products constituted of tetrahydroisoquinolines. The synthetic chemistry that will be developed shall be utilized to prepare analogues of the natural substances as biological, biosynthetic and mechanistic probes. This proposal is primarily hypothesis-driven, and extensively employs new synthetic methodologies developed in this laboratory for the construction of such agents. The specific aims of this program are to study the interaction of the natural antitumor antibiotics and mechanistically inspired synthetic analogs, including ecteinascidin 743 (Et-743), saframycin, jorumycin, tetrazomine, lemonomycin and the bioxalomycins with cellular nucleic acids. The DNA-alkylating capacity of these drugs compared with their ability to cause oxidative damage to nucleic acids will be explored. The synthesis of members of this class of antitumor drugs will continue to be developed with the objective of harnessing the synthetic methodology developed to make new, less toxic, more selective and more potent antitumor drugs. In addition, the tools of synthesis will be exploited to synthesize mechanistic probes for the interaction of these substances with cellular nucleic acids and proteins that bind to cellular nucleic acids. We have recently discovered that bioxalomycin 12 specifically cross-links duplex DNA at 54dCpG34 steps. We propose to elucidate the exact molecular structure of the covalent adduct. This finding has inspired new design concepts for simpler analogs based on the tetrahydroisoquinoline core that may be capable of alkylating and cross-linking DNA as well as potentially cross-linking DNA to DNA-binding proteins. The antiproliferative activity of this family of alkaloids is intimately associated with the capacity of these agents to bind to and covalently modify DNA. This is particularly evident in the case of Et-743. Plans are presented to mechanistically separate the DNA alkylation and cross-linking chemistry of these agents from their capacity to inflict oxidative damage on cells. The investigation of the biosynthesis of Et-743 with a particular focus on the late-stage assembly of the macrocyclic sulfide-bridged spiro-tetrahydroisoquinoline ring system will be pursued. We plan to apply high throughput genome sequencing methods using 454 technology to identify the Et-743 biosynthetic gene cluster from Ecteinascidia turbinata. The ultimate goals of the biosynthesis studies are to genetically engineer a fermentable microorganism to produce Et-743 for clinical use. PUBLIC HEALTH RELEVANCE: The purpose of this application is to utilize the tools of chemical synthesis to study the molecular details of how Nature biosynthesizes anti-cancer drugs. In particular, this program will deploy new technologies to produce the clinically relevant anticancer drug ecteinascidin 743 (Et-743) on industrially practical scale through genetic engineering of a microbial host. In addition, the chemical technologies being developed will be applied to the design and synthesis of new anti-cancer drugs. | 1.27 FTE [NAME], 1.0 Postdoctoral Fellow | 2.27
20093785979618R03AI083254-01G | COLORADO STATE UNIVERSITY | SPONSORED PROGRAMS | 805232002 | 73500 | 10464.69 | We will develop controlled vocabularies (sets of standardized and defined terms) and ontologies (sets of standardized and defined controlled vocabulary terms and their inter-relationships) for vector surveillance and vector management. Use of these controlled vocabularies and ontologies in decision support systems for vector-borne diseases will: 1) remedy the current use of nebulous vector surveillance and vector management terms without formal definitions and relationships, 2) improve data quality and data integration and 3) facilitate standardized monitoring and evaluation of vector control interventions. | .12 FTE Teaching Faculty; .79 FTE Research Faculty | 0.92
20093795492396P0033A096961G | STATE BOARD FOR COMMUNITY COLLEGES AND OCCUPATIONAL EDUCATIONAL SYSTEM | RED ROCKS COMMUNITY COLLEGE | 802281255 | 26196 | 12330.11 | The FWS Program provided funds that are earned through part-time employment to assist students in financing the cost of postsecondary education.\n\n | Part-time student employment\n\n | 1
20093795492396P033A096967G | STATE BOARD FOR COMMUNITY COLLEGES AND OCCUPATIONAL EDUCATIONAL SYSTEM | RED ROCKS COMMUNITY COLLEGE | 800312105 | 66159 | 66159 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education.\n\n | Part time student employment\n\n | 3
20093796082550P033A096435G | STATE BOARD FOR COMMUNITY COLLEGES AND OCCUPATIONAL EDUCATIONAL SYSTEM | COMMUNITY COLLEGE OF AURORA | 800119057 | 26196 | 26196 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education.\n\n | Part time student employment | 2
20093796082600P033A096962G | STATE BOARD FOR COMMUNITY COLLEGES AND OCCUPATIONAL EDUCATIONAL SYSTEM | COMMUNITY COLLEGE OF DENVER | 802173363 | 42563 | 0 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education.\n\n | Part Time Student Employment\n\n | 1
200937962597031D1NHP15413-01-00G | STATE BOARD FOR COMMUNITY COLLEGES AND OCCUPATIONAL EDUCATIONAL SYSTEM | PUEBLO COMMUNITY COLLEGE | 810041499 | 791491 | 0 | Health Resources and Services Administration (HRSA) Nursing Workforce Diversity Program\n\n |  | 0
20093796259703P033A095573 G | STATE BOARD FOR COMMUNITY COLLEGES AND OCCUPATIONAL EDUCATIONAL SYSTEM | PUEBLO COMMUNITY COLLEGE | 810041499 | 45291 | 1000 | The FWS Program provides funds that are earned through part-time employment to assist students in financing the costs of postsecondary education.\n\n | Part time student employment\n\n | 1
20093835449125POO033A090723G | METROPOLITAN STATE COLLEGE OF DENVER |  | 802173362 | 131834 | 58005.18 | The Federal Work Study program provides funds that are earned through part time employment to assist students in financing the costs of post secondary education.\n\n | Part time student employment\n\n | 6
20093848565532DE-EE0000082G | NATURAL RESOURCES, COLORADO DEPARTMENT OF | GOVERNOR'S ENERGY OFFICE | 802031940 | 49222000 | 298883.88 |  | For the 1st quarter ending 09/30/2009, 13.05998 FTE jobs were created or retained by the primary recipient and .14 FTE jobs were created or retained in the form of legal services. | 13.2
20093848565532DE-EE0000913G | NATURAL RESOURCES, COLORADO DEPARTMENT OF | GOVERNOR'S ENERGY OFFICE | 802031940 | 9593500 | 0 | Fund energy efficiency and renewable energy programs and projects in small communities of 35,000 and less in Colorado. | No Jobs have been created as of 09/30/2009 | 0
20093848565532DE-EE0001579G | NATURAL RESOURCES, COLORADO DEPARTMENT OF | GOVERNOR'S ENERGY OFFICE | 802031940 | 4739000 | 0 | Offers consumer incentives for the purchase of ENERGY STAR appliances to replace an inefficient unit; includes refrigerators, clothes dryers, clothes washers, furnaces, boilers and hot water heaters. | No Jobs have been created as of 09/30/2009. | 0
20093848565532DE-OE0000066G | NATURAL RESOURCES, COLORADO DEPARTMENT OF | GOVERNOR'S ENERGY OFFICE | 802031940 | 653209 | 0 | To build regional energy assurance capability to allow the State of Colorado to coordinate and communicate statewide and with critical energy infrastructure partners on the following issues: a) energy security b) grid reliability c) emergency response and d) large scale disruptions. | No Jobs have been created as of 09/30/2009. | 0
20093878147602H393A090097G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 802031774 | 7954827 | 71499.64 | Assist States in the implementation of a statewide, comprehensive, coordinated, multidisciplinary, interagency system of early intervention services for infants and toddlers with disabilities and their families. | Professional development project staff | 4.42
20093878147602H398A090009G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 802031702 | 242913 | 0 | A state program to provide independent living services to individuals with significant disabilities, support the operation of centers for independent living and the Statewide Independent Living Council, provide training on the independent living philosophy and outreach to unserved and underserved populations, conduct studies and analysis and present information to policymakers to enhance independent living services, and support activities that increase the capacity of independent living service providers. |  | 0
20093878147602H399A090006G | HUMAN SERVICES, COLORADO DEPARTMENT OF |  | 802031702 | 497578 | 0 | A state program to provide independent living services to older individuals who are blind, conduct activities that will improve or expand such services and help improve public understanding of the problems of such individuals. |  | 0
200938782088262A-97881001-0G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 850000 | 368.36 | The intent of the ARRA-fortified DERA funds is to provide cost effective air pollution reduction for public health benefits, especially in areas with air toxics concerns.  Fuel savings via idling reduction and job creation or preservation are important secondary goals.  Funds awarded under the competitive grant will be used to retrofit approximately 180 over-the-road trucks with auxilary power units, which significantly reduce idling time, thus reducing emissions and conserving diesel fuel.\n\n | Program manager to write the Request for Proposal (RFP) | 0
200938782088262B-97863101-0G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 1350000 | 0 | This award provides stimulus funding to CDPHE to utilize funding to provide a Revolving Loan Fund for the community to assist funding cleanup planning and remediation activities.  The purpose of these activities is to promote redevelopment of the funded sites and future reuse of the property that does not pose a threat to human health and the environment.\n\n | No jobs created to date | 0
200938782088262D-97878401-0G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 1730000 | 60468.72 | The intent of the ARRA-fortified DERA funds is to provide cost effective air pollution reduction for public health benefits, especially in areas with air toxics concerns.  Fuel savings via idling reduction and job creation or preservation are important secondary goals.  Funds awarded under the non-competitive grant will be used to retrofit approximately 330 school buses in Weld, El Paso and Mesa counties.\n\n | The CDPHE (Prime Recipient) has allocated 0.48 FTE to this project for this reporting period. Positions include: 1 Project Manager, 1 Program Manager, and 3 Installation Quality Assurance personnel. All 5 of the positions contribute to Program outreach. CDPHE's Vendor, Instrument Sales and Service, Inc., devotes portions of several positions:  1 Production Manager, 1 Inventory Coordinator, 1 Sales Manager, 1 Operations Manager, 1 Business Manager, 1 Project Coordinator, and 2 Retrofit Equipment Installers--one of which is a newly created position . Total Vendor FTE dedicated to this project for the reporting period is 0.86 FTE. Combined FTE for Prime-recipient and Vendor: 0.48 FTE + 0.86 FTE = 1.34 FTE for the reporting period.    \n\n | 1.34
200938782088262P-97881901-0G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 317100 | 0 | This project will involve updating water quality planning to identify cost effective and locally-derived point and non-point controls to maintain state water quality standards for surface and ground waters in each of the principle river basins in Colorado. | No jobs created to date | 0
200938782088262S-97842001-0G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 811329513 | 17000000 | 4272.06 | Funding for remedial design and construction costs at the Summitville Superfund project. \n\n | Haul truck driver, large equipment operator, laborer. | 2.02
200938782088262S-97882701-0G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 804442000 | 1400000 | 0 | This  award will fund portions of the Central City/Clear Creek Superfund Site Operable Unit 4 remedial design, specifically the design of a new water treatment plant.  This plant will treat acid mine drainage from the National Tunnel and Gregory Incline.\n\n | No jobs created to date | 0
200938782088263H23IP822564-07S1G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 490402 | 0 | Funding will be used to develop the capacity for billing health insurance plans for services provided to health plan members by state and local health department clinics.\n\n | No jobs created to date | 0
200938782088263H23IP822564-07S2G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 267602 | 0 | Funding will be used to develop ôbest practicesö for monitoring school vaccination coverage, entry requirements and exemption rates, using innovative approaches\n\n | No jobs created or retained to date | 0
200938782088263H23IP822564-07S3G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 144699 | 0 | Funding will be used to improve data quality and enhancing assessment at Immunization Information Systems Sentinel Sites\n\n | No jobs created to date | 0
200938782088263H23IP822564-07S4G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 1686998 | 0 | Increase the number of children and adults vaccinated against vaccine-preventable diseases.\n\n | No jobs created to date | 0
200938782088263U01CI000305-05S1G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 414402 | 16 | The Colorado Department of Public Health and Environment (CDPHE) is applying for a five- year continuation of its existing Emerging Infections Program (EIP) which was established in 2000. The Colorado EIP will participate in the national network of population-basedcenters to collectively assess the public health impact of emerging infections and respond to emerging infections of public health importance. Proposed activities include: active, population-based surveillance for selected pathogens and syndromes; applied public health epidemiology and laboratorytesting; and the piloting and evaluation of methods for prevention and control of emerging infectious diseases. Specific projects being proposed include: 1) Active Bacterial Core Surveillance (ABCs), including MRSA surveillance and supplemental surveillance for invasive pneumococcal infections in children 24-59 months of age; 2) Foodborne Disease Active Surveillance (FoodNet), including completion of infant Salmonella and Campylocbacter case-control studies, completion of Giardia case-control study, implementing a study of health consequences of antimicrobial-resistant Salmonella, a retail food study to better understand regional differences in Campylocbacter, and molecular subtyping of norovirus strains; 3) Surveillance for Respiratory Diseases and Syndromes, including developing capacity to investigate outbreaks of unknown acute respiratory illness; 4) Flexible response to emerging problems; 5) Rapid population surveys; 6) Integrated hepatitis surveillance; and 7) Creutzfeld-Jakob Disease (CJD) surveillance, including the hunter license project.\n\n | No new positions created to date | 0
200938782088263U01CI000305-05S2G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 189797 | 0 | The Colorado Department of Public Health and Environment (CDPHE) is applying for a five- year continuation of its existing Emerging Infections Program (EIP) which was established in 2000. The Colorado EIP will participate in the national network of population-basedcenters to collectively assess the public health impact of emerging infections and respond to emerging infections of public health importance. Proposed activities include: active, population-based surveillance for selected pathogens and syndromes; applied public health epidemiology and laboratorytesting; and the piloting and evaluation of methods for prevention and control of emerging infectious diseases. Specific projects being proposed include: 1) Active Bacterial Core Surveillance (ABCs), including MRSA surveillance and supplemental surveillance for invasive pneumococcal infections in children 24-59 months of age; 2) Foodborne Disease Active Surveillance (FoodNet), including completion of infant Salmonella and Campylocbacter case-control studies, completion of Giardia case-control study, implementing a study of health consequences of antimicrobial-resistant Salmonella, a retail food study to better understand regional differences in Campylocbacter, and molecular subtyping of norovirus strains; 3) Surveillance for Respiratory Diseases and Syndromes, including developing capacity to investigate outbreaks of unknown acute respiratory illness; 4) Flexible response to emerging problems; 5) Rapid population surveys; 6) Integrated hepatitis surveillance; and 7) Creutzfeld-Jakob Disease (CJD) surveillance, including the hunter license project. | No jobs created to date | 0
200938782088263U50CI823801-05S1G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 977516 | 0 | Enhance capacity to investigate, control and report Healthcare associated infections.  [NAME] out activities to reduce healthcare-associated infections (HAI's). | We are presently recruiting for 3 new positions:  A public health nurse consultant, an epidemiologist, and .5 FTE quality improvement specialist. We expect to have the new hires on board no later than November.\n\n | 0
20093878208826H5BHP16811G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 800000 | 0 | Funds to support the state's ability to support recruitment and retention of primary health practitioners in areas of Colorado determined to have a shortage of providers.  Funding will be used to forgive a portion of the provider's educational loan debt in exhange for a contracted period of service in identified health professional shortage areas. \n\n | No jobs created to date | 0
20093878208826U6AHP16564G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 35840 | 0 | Assist State Primary Care Offices in coordination of activities for the delivery of Primary Care Services, recruitment and retention of Critical Health Care Providers\n\nAdministration of the State Primary Care Office | No jobs created to date | 0
20093878208826WIEBT-ARRA-09-CO-02G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 444066 | 0 | These funds will be used to determine if Electronic Benefits Transfer (EBT) is feasible for the Colorado WIC program.  If EBT is determined to be feasbile, the program would pursue funding for implementation.  If implemented, WIC would provide food benefits to participants via an electronic transaction at the grocery store instead of paper checks.\n\n | No jobs created to date | 0
20093878208826WISA-09-CO-01G | PUBLIC HEALTH AND ENVIRONMENT, COLORADO DEPARTMENT OF |  | 802461530 | 1022022 | 0 | These funds will promote the development of model WIC systems by consortiums, referred to as State Agency Models.  These processes support the agency's goal to improve the stewardship of federal funds by replacing state agency legacy systems to increase the efficiency, capability and consistency for tracking program expenditures, infant formula rebates, program income and other financial aspects.\n\n | No jobs created to date | 0
200938782092952L-97882301-0G | LABOR & EMPLOYMENT, COLORADO DEPARTMENT OF |  | 802023660 | 2540000 | 7870.26 | ARRA ACT-LEAKING UNDERGROUND STORAGE TANK (LUST) \n\n66.805\n\nAdditional financial assistance source to assess and cleanup petroleum releases from underground storage tanks (LUST) sites in Colorado. \n\n | Environmental Protection Agency LEAKING UNDERGROUND STORAGE TANK (LUST).93 FTE [CFDA 66.805]\n\nTwo administrative assistants were hired to assist with filing, copying, and scanning of documents associated with the ARRA LUST Grant and other applicable duties. | 0.93
20093878209295UI-18010-09-55-A-8G | LABOR & EMPLOYMENT, COLORADO DEPARTMENT OF |  | 802023660 | 1505306 | 1012132.97 | 1. RECOVERY ACT-FEDERAL ADDITIONAL UNEMPLOYMENT  COMPENSATION ADMIN (FEUC)FY09\n\n09-A220-AUET-4123-5UCR1-000/17.225/PMS# UI180106T0/\n\n2. RECOVERY ACT-EMERGENCY UNEMPLOYMENT COMPENSATION ADMIN ([NAME] 09-A220-AXAA-4110-5UIR2-000/17.225/PMS# [NAME]. RECOVERY ACT-STATE EXTENDED BENFIT ADMIN/17.225\n\nProvides funding to extend the number of weeks an eligible claimant can receive unemployment benefits. In addition, increased the amount of weekly benefit payments by $25. | 1: FEDERAL ADDITIONAL UNEMPLOYMENT COMPENSATION ADMIN (FAUC) 0 FTE [CFDA 17.225/PMS#UI180106T0] 2.EMERGENCY UNEMPLOYMENT COMPENSATION ADMIN (EUC)[CFDA 17.225/PMS# UI180109M0] 9.02 FTE 3.STATE EXTENDED BENEFITS ADMIN 6.27 FTE\n\n These are Labor and Employment Specialist's who communicate with claimants through a call center environment, assist in the processing of claims and provide adjudication of claims. | 15.29
200938783555512009-SU-B9-0020G | PUBLIC SAFETY COLORADO DEPT | DIVISION OF CRIMINAL JUSTICE | 802155885 | 18323383 | 117445.54 | The [NAME] Justice [NAME] ([NAME] is the primary provider of federal criminal justice funding to state and local jurisdictions.  JAG funds support all components of the criminal justice system, from multi-jurisdictional drug and gang task forces to crime prevention and domestic violence programs, courts, corrections, treatment, and justice information sharing initiatives.  JAG funded projects may address crime through the provision of services directly to individuals and/or communities and by improving the effectiveness and efficiency of criminal justice systems, processes and procedures. | 1.79 FTE created or retained at the Division of Criminal Justice for grant administration.  These include in whole or in part, 2 grant managers, 1 contract and grant administrator, and 1 administrative assistant. | 1.79
20093879015899L09AC15621G | NATURAL RESOURCES, COLORADO DEPARTMENT OF | EXECUTIVE DIRECTOR'S OFFICE | 802032273 | 30000 | 8600 | Construction activites to close hazardous mine openings within the area of the BLM Gunnison field office.  These openings pose the threat of injury or death to visitors on public land. |  | 0
20093879015899L09AC15878G | NATURAL RESOURCES, COLORADO DEPARTMENT OF | EXECUTIVE DIRECTOR'S OFFICE | 802032273 | 30000 | 0 | Construction activities to close hazardous mines that have been open.  They will be closed so that the general public cannot enter the mine and be hurt or killed. Openings will be closed by backfilling, blasting or installing a grate to cover the opening. |  | 0
20093879015899L09AC15879G | NATURAL RESOURCES, COLORADO DEPARTMENT OF | EXECUTIVE DIRECTOR'S OFFICE | 802032273 | 30000 | 0 | Construction activities to close hazardous mines that have been open.  They will be closed so that the general public cannot enter the mine and be hurt or killed. Openings will be closed by backfilling, blasting or installing a grate to cover the opening. |  | 0
20093879015899L09AC15883G | NATURAL RESOURCES, COLORADO DEPARTMENT OF | EXECUTIVE DIRECTOR'S OFFICE | 802032273 | 5000 | 0 | Construction activities to close hazardous mines that have been open.  They will be closed so that the general public cannot enter the mine and be hurt or killed. Openings will be closed by backfilling, blasting or installing a grate to cover the opening. |  | 0
20093879015899L09AC15884G | NATURAL RESOURCES, COLORADO DEPARTMENT OF | EXECUTIVE DIRECTOR'S OFFICE | 802032273 | 5000 | 0 | Construction activities to close hazardous mines that have been open.  They will be closed so that the general public cannot enter the mine and be hurt or killed. Openings will be closed by backfilling, blasting or installing a grate to cover the opening. |  | 0
20093879015899L09AC16008G | NATURAL RESOURCES, COLORADO DEPARTMENT OF | EXECUTIVE DIRECTOR'S OFFICE | 802032273 | 5000 | 0 | Construction activities to close hazardous mines that have been open.  They will be closed so that the general public cannot enter the mine and be hurt or killed. Openings will be closed by backfilling, blasting or installing a grate to cover the opening. |  | 0
200939607387710253207G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 4159565 | 0 | Highway Infrastructure Investment Grant: Available for Use in Any Area (flexible) | To create or retain professional, technical, and labor jobs in the transportation industry | 0
200939607387710405033G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 555000 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771050A009G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 798753 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
200939607387712254078G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 1077890 | 0 | Highway Infrastructure Investment Grant: Available for Use in Any Area (flexible) | To create or retain professional, technical, and labor jobs in the transportation industry | 0
200939607387715502064G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 5000 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771C010103G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 13079880 | 0 | Highway Infrastructure Investment Grant: Urbanized Areas over 200K Population | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771C120018G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 15225565 | 0 | Highway Infrastructure Investment Grant: Urbanized Areas over 200K Population | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771C200006G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 273733 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M070002G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 20500 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M070002G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 20500 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M110066G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 318270 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M190003G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 838000 | 0 | Highway Infrastructure Investment Grant: Urbanized Areas over 200K Population | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M256012G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 40000 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M320064G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802099999 | 250000 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M405013G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 140000 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M415012G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 354000 | 0 | Highway Infrastructure Investment Grant: Urbanized Areas over 200K Population | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M465007G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 20000 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M470009G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 280000 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M560002G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 204888 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M830046G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 130000 | 0 | Highway Infrastructure Investment Grant: Urbanized Areas over 200K Population | To create or retain professional, technical, and labor jobs in the transportation industry | 0
20093960738771M835002G | TRANSPORTATION, COLORADO DEPARTMENT OF |  | 802223406 | 968095 | 0 | Highway Infrastructure Investment Grant: Transportation Enhancements | To create or retain professional, technical, and labor jobs in the transportation industry | 0