Spreadsheet: f9703852-358a-4619-be08-2be42049cf58
Sheet: Sheet1

PCDB ID | [NAME] ([NAME]) | Accession | Entry name | Protein names | Gene names | Organism | Domain Length | [NAME] | Subcellular locations | Protein family | Pathways involved | Keywords | Interactions | Features | InterPro | EC numbers | GO terms | GO IDs | Organism ID | PCD cause: mutation | PCD cause: ligand | PCD cause: oligomeric state | PCD cause: pH | Pair of structures exhibiting [NAME] (CATH Ids) | Sequential identity percentage between pair of structures exhibiting [NAME] | experimental method (structure 1) | experimental method (structure 2) | Rosetta free energy score (structure 1) | Rosetta free energy score (structure 2)
1115 | 3.53 | Q8WTS6 | SETD7_HUMAN | Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase [NAME]) (H3-K4-HMTase SETD7) (SET domain-containing protein 7) (SET7/9) (Lysine N-methyltransferase 7) | SETD7 KIAA1717 KMT7 SET7 SET9 | Homo sapiens (Human) | 134 | 366 | Nucleus. | Histone-lysine methyltransferase family; SET7 subfamily | no_data | 3D-structure; Activator; Chromatin regulator; Chromosomal protein; [NAME] proteome; Direct protein sequencing; Methyltransferase; [NAME]; Repeat; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase | P68431; P68433; Q12962; P04637 | Beta strand (21); Binding site (4); Chain (1); Compositional bias (1); Domain (1); Erroneous initiation (1); [NAME] (5); Mutagenesis (6); Region (4); Repeat (3); Turn (3) | IPR017155; IPR003409; IPR001214 | 2.1.1.43 | chromatin modification; chromosome; histone-lysine N-methyltransferase activity; nucleus; protein binding; regulation of transcription; DNA-dependent; transcription | GO:0016568; GO:0005694; GO:0018024; GO:0005634; GO:0005515; GO:0006355; GO:0006350 | 9606 | False | False | False | True | 1h3iA01 1mt6A01 | 98.5294 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -424.493398793 | -424.522075222
6687 | 2.16 | Q9BMI9 | Q9BMI9_SCHMA | Purine-nucleoside phosphorylase (EC 2.4.2.1) | no_data | Schistosoma mansoni (Blood fluke) | 271 | 287 | no_data | no_data | no_data | Glycosyltransferase; Transferase | no_data | no_data | IPR011268; IPR000845; IPR011270; IPR001369 | 2.4.2.1 | nucleoside metabolic process; purine-nucleoside phosphorylase activity | GO:0009116; GO:0004731 | 6183 | False | False | False | False | 1tcvA00 1td1B00 | 98.1752 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -884.658590168 | -884.784297314
2527 | 2.06 | [NAME] | IGHE_HUMAN | Ig epsilon chain C region | IGHE | Homo sapiens (Human) | 108 | 428 | no_data | no_data | no_data | 3D-structure; [NAME] proteome; Direct protein sequencing; Disulfide bond; [NAME]; Immunoglobulin C region; Immunoglobulin domain; Polymorphism; Repeat | no_data | Beta strand (23); Chain (1); Disulfide bond (8); Domain (4); Erroneous initiation (1); Glycosylation (6); [NAME] (8); Natural variant (2); Non-terminal residue (1); Turn (2) | IPR007110; IPR013783; IPR003006; IPR003597 | no_data | antigen binding; immune response | GO:0003823; GO:0006955 | 9606 | True | True | True | True | 1fp5A02 1o0vB03 | 98.1818 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -316.63989309 | -316.571762858
1135 | 2.12 | P54939 | TLN1_CHICK | Talin-1 | TLN1 TLN | Gallus gallus (Chicken) | 93 | 2541 | Cell projection ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº cytoskeleton. | no_data | no_data | 3D-structure; Cell membrane; Cell projection; Cytoplasm; Cytoskeleton; Direct protein sequencing; [NAME]; [NAME]; [NAME] | P05106; P18206 | Beta strand (8); Chain (1); Compositional bias (2); Domain (2); Glycosylation (2); [NAME] (13); Region (1); Turn (5) | IPR019749; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR002558; IPR002404; IPR011993; IPR015224; IPR015710; IPR015009 | no_data | [NAME]; cytoskeletal anchoring at plasma membrane; cytoskeleton; cytosol; focal adhesion; insulin receptor binding; ruffle membrane; structural constituent of cytoskeleton | GO:0003779; GO:0007016; GO:0005856; GO:0005829; GO:0005925; GO:0005158; GO:0032587; GO:0005200 | 9031 | False | False | True | True | 1mixA02 1mk7B02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -275.778855652 | -275.900244908
87 | 2.13 | P00183 | CPXA_PSEPU | Camphor 5-monooxygenase (EC 1.14.15.1) (Cytochrome P450-cam) (Cytochrome P450cam) | camC cyp101 | Pseudomonas putida | 429 | 415 | Cytoplasm. | Cytochrome P450 family | Terpene metabolism; (R)-camphor degradation. | 3D-structure; Cytoplasm; Direct protein sequencing; Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase | no_data | Beta strand (13); Chain (1); [NAME] (25); Initiator methionine (1); Metal binding (1); [NAME] conflict (4); Turn (6) | IPR001128; IPR002397; IPR017973; IPR017972 | 1.14.15.1 | camphor 5-monooxygenase activity; cytoplasm; electron carrier activity; heme binding; oxidation reduction | GO:0018683; GO:0005737; GO:0009055; GO:0020037; GO:0055114 | 303 | False | False | False | True | 1k2oA00 1gjmA00 | 99.7537 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1344.75825212 | -1344.00376379
1902 | 13.09 | Q94734 | NP4_RHOPR | Nitrophorin-4 (NP4) | no_data | Rhodnius prolixus (Triatomid bug) | 184 | 205 | Secreted. | Calycin superfamily; [NAME] family | no_data | 3D-structure; Disulfide bond; Heme; Iron; Metal-binding; Secreted; Signal; Vasoactive; Vasodilator | no_data | Beta strand (10); Chain (1); Disulfide bond (2); [NAME] (5); Metal binding (1); Signal peptide (1); Turn (1) | IPR012674; IPR011038; IPR002351 | no_data | extracellular region; metal ion binding; vasodilation | GO:0005576; GO:0046872; GO:0042311 | 13249 | False | False | False | True | 3c78X00 2ofmX00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -593.483443685 | -593.108088513
6818 | 4.08 | P00489 | PYGM_RABIT | Glycogen phosphorylase; muscle form (EC 2.4.1.1) (Myophosphorylase) | PYGM | Oryctolagus cuniculus (Rabbit) | 476 | 843 | no_data | Glycogen phosphorylase family | no_data | 3D-structure; Acetylation; Allosteric enzyme; Carbohydrate metabolism; Direct protein sequencing; Glycogen metabolism; Glycosyltransferase; Nucleotide-binding; [NAME]; Pyridoxal phosphate; Transferase | no_data | Beta strand (26); Binding site (1); Chain (1); [NAME] (47); Initiator methionine (1); Modified residue (5); [NAME] conflict (10); Site (3); Turn (7) | IPR011833; IPR000811 | 2.4.1.1 | glycogen metabolic process; nucleotide binding; phosphorylase activity; pyridoxal phosphate binding | GO:0005977; GO:0000166; GO:0004645; GO:0030170 | 9986 | False | False | True | False | 2pyiA01 2gpaA01 | 99.3763 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1618.02607267 | -1616.83212982
5178 | 2.15 | Q63537 | SYN2_RAT | Synapsin-2 (Synapsin II) | Syn2 | Rattus norvegicus (Rat) | 119 | 586 | Cell junction ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº synapse. | [NAME] family | no_data | 3D-structure; Alternative splicing; Cell junction; Direct protein sequencing; [NAME]; [NAME] | no_data | Alternative sequence (2); Beta strand (17); Chain (1); Compositional bias (2); [NAME] (10); Modified residue (2); Region (6); Turn (3) | IPR013816; IPR016185; IPR001359; IPR019735; IPR019569; IPR019736 | no_data | ATP binding; catalytic activity; cell junction; cytoskeletal protein binding; neurotransmitter secretion; regulation of neurotransmitter secretion | GO:0005524; GO:0003824; GO:0030054; GO:0008092; GO:0007269; GO:0046928 | 10116 | False | True | False | False | 1i7nA03 1i7lA03 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -367.640053151 | -367.323115087
1204 | 2.34 | [NAME] | DRK_DROME | Protein enhancer of sevenless 2B (Protein E(sev)2B) (SH2-SH3 adapter [NAME]) (Downstream of receptor kinase) | [NAME] | Drosophila melanogaster (Fruit fly) | 59 | 211 | Membrane; Peripheral membrane protein. | GRB2/sem-5/DRK family | no_data | 3D-structure; [NAME] proteome; Membrane; Repeat; SH2 domain; SH3 domain; Transducer | Q9W5C6; P22681; Q8T4F7; Q9W3N8; P26675 | Beta strand (4); Chain (1); Domain (3); Mutagenesis (5) | IPR000108; IPR000980; IPR001452; IPR020473 | no_data | [NAME] protein signal transduction; SH3/SH2 adaptor activity; actin filament organization; activation of JNKK activity; anterior/posterior axis specification; embryo; embryonic development via the syncytial blastoderm; imaginal disc-derived wing morphogenesis; plasma membrane; regulation of cell shape; sevenless binding; sevenless signaling pathway; torso signaling pathway | GO:0007265; GO:0005070; GO:0007015; GO:0007256; GO:0008595; GO:0001700; GO:0007476; GO:0005886; GO:0008360; GO:0005118; GO:0045500; GO:0008293 | 7227 | False | False | False | False | 2a36A00 2azsA00 | 100 | SOLUTION NMR | SOLUTION NMR | -148.659558665 | -148.455891521
5293 | 2.67 | P0A0N4 | QACR_STAAU | HTH-type transcriptional regulator qacR | qacR | Staphylococcus aureus | 137 | 188 | no_data | no_data | no_data | 3D-structure; DNA-binding; Direct protein sequencing; [NAME]; Repressor; Transcription; Transcription regulation | no_data | Beta strand (2); Chain (1); DNA binding (1); Domain (1); [NAME] (11); Mutagenesis (2); Turn (2) | IPR009057; IPR012287; IPR015893; IPR011075; IPR013571; IPR001647 | no_data | negative regulation of transcription; regulation of transcription; DNA-dependent; specific transcriptional repressor activity; transcription; transcription factor activity | GO:0016481; GO:0006355; GO:0016566; GO:0006350; GO:0003700 | 1280 | False | False | True | True | 2g0eA02 1jumA02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -460.82150065 | -460.319974999
1275 | 3.03 | P07597 | NLTP1_HORVU | Non-specific lipid-transfer protein 1 (LTP 1) (Probable amylase/protease inhibitor) | LTP1 PAPI | Hordeum vulgare (Barley) | 91 | 117 | no_data | Plant LTP family | no_data | 3D-structure; Direct protein sequencing; Disulfide bond; Lipid-binding; [NAME]; Signal; Transport | no_data | Chain (1); Disulfide bond (4); Erroneous gene model prediction (1); [NAME] (7); Lipidation (1); Signal peptide (1) | IPR016140; IPR013770; IPR003612; IPR000528 | no_data | lipid binding; lipid transport | GO:0008289; GO:0006869 | 4513 | False | False | False | True | 1jtbA00 1lipA00 | 100 | SOLUTION NMR | SOLUTION NMR | -245.403096084 | -245.788956571
5872 | 2.94 | O07897 | O07897_THETH | Heat resistant RNA dependent ATPase | HERA | [NAME] | 220 | 510 | no_data | DEAD box helicase family | no_data | ATP-binding; Helicase; [NAME]; Nucleotide-binding | no_data | no_data | IPR014001; IPR001650; IPR011545; IPR014021; IPR000629; IPR014014 | no_data | ATP binding; ATP-dependent helicase activity; nucleic acid binding | GO:0005524; GO:0008026; GO:0003676 | 274 | False | False | False | True | 2gxqA00 2gxsA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -706.24233052 | -705.269210247
264 | 2.62 | Q02054 | [NAME] | Actinorhodin polyketide synthase acyl carrier protein (ACP) (actI ORF3) | SCO5089 [NAME] | Streptomyces coelicolor | 86 | 86 | no_data | no_data | Antibiotic biosynthesis; actinorhodin biosynthesis. | 3D-structure; Antibiotic biosynthesis; Complete proteome; [NAME] | no_data | Chain (1); [NAME] (3); Modified residue (1); Turn (5) | IPR009081; IPR006163; IPR006162 | no_data | acyl carrier activity; antibiotic biosynthetic process; cofactor binding; phosphopantetheine binding | GO:0000036; GO:0017000; GO:0048037; GO:0031177 | 1902 | False | False | False | False | 1af8A00 2af8A00 | 100 | SOLUTION NMR | SOLUTION NMR | -235.983228014 | -236.372512405
5651 | 2.63 | P07591 | TRXM_SPIOL | [NAME]; chloroplastic (Trx-M) [Cleaved into: [NAME] Mc; [NAME] Md] | no_data | Spinacia oleracea ([NAME]) | 104 | 181 | Plastid ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº chloroplast. | [NAME] family; Plant M-type subfamily | no_data | 3D-structure; Chloroplast; Direct protein sequencing; Disulfide bond; Electron transport; Plastid; Redox-active center; Transit peptide; Transport | Q55389; Q9LU86 | Active site (2); Beta strand (4); Chain (3); Disulfide bond (1); Domain (1); [NAME] (4); Natural variant (3); [NAME] conflict (4); Site (3); Transit peptide (1); Turn (4) | IPR005746; IPR017936; IPR012336; IPR006662; IPR015467; IPR017937; IPR013766; IPR012335 | no_data | cell redox homeostasis; chloroplast; electron carrier activity; electron transport chain; glycerol ether metabolic process; protein binding; protein disulfide oxidoreductase activity; transport | GO:0045454; GO:0009507; GO:0009055; GO:0022900; GO:0006662; GO:0005515; GO:0015035; GO:0006810 | 3562 | False | False | False | True | 1fb6A00 1gl8A00 | 100 | X-RAY DIFFRACTION | SOLUTION NMR | -320.161188519 | -320.717265559
12 | 2.8 | P06019 | RPC1_BPMU | Repressor protein CI | CI 1 | Enterobacteria phage Mu (Bacteriophage Mu) | 69 | 174 | no_data | no_data | no_data | 3D-structure; DNA-binding; Repressor; Transcription; Transcription regulation | no_data | Beta strand (2); Chain (1); [NAME] (3); Turn (1) | IPR009061; IPR003314; IPR011991 | no_data | DNA binding; nucleotide binding; regulation of transcription; transcription | GO:0003677; GO:0000166; GO:0045449; GO:0006350 | 10677 | False | False | False | False | 1g4dA00 1qpmA00 | 100 | SOLUTION NMR | SOLUTION NMR | -200.935313648 | -201.309842165
961 | 5.5 | P01132 | EGF_MOUSE | Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor] | Egf | Mus musculus (Mouse) | 53 | 1217 | Membrane; Single-pass type I membrane protein. | no_data | no_data | 3D-structure; Direct protein sequencing; Disulfide bond; EGF-like domain; [NAME]; Growth factor; Membrane; Repeat; Signal; [NAME] | no_data | Beta strand (3); Chain (2); Disulfide bond (24); Domain (9); Frameshift (1); Glycosylation (4); Region (1); Repeat (8); Sequence conflict (4); Signal peptide (1); Topological domain (2); [NAME] (1); Turn (2) | IPR011042; IPR006209; IPR006210; IPR013032; IPR000152; IPR001336; IPR000742; IPR001881; IPR013091; IPR018097; IPR000033; IPR016317 | no_data | activation of MAPKK activity; branching morphogenesis of a tube; calcium ion binding; extracellular space; growth factor activity; integral to membrane; mammary gland alveolus development; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of granule cell precursor proliferation; regulation of peptidyl-tyrosine phosphorylation | GO:0000186; GO:0048754; GO:0005509; GO:0005615; GO:0008083; GO:0016021; GO:0060749; GO:0018108; GO:0005886; GO:0021940; GO:0050730 | 10090 | False | False | False | False | 1egfA00 1ephA00 | 100 | SOLUTION NMR | SOLUTION NMR | -109.907754349 | -109.566748019
4754 | 2.71 | P27616 | PUR7_YEAST | Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase) | ADE1 YAR015W | Saccharomyces cerevisiae ([NAME]'s yeast) | 111 | 306 | no_data | SAICAR synthetase family | Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. | 3D-structure; ATP-binding; Acetylation; [NAME] proteome; Ligase; Nucleotide-binding; [NAME]; Purine biosynthesis | Itself | Beta strand (11); Chain (1); [NAME] (9); Modified residue (2); [NAME] conflict (3); Turn (18) | IPR013816; IPR001636; IPR018236 | 6.3.2.6 | de novo' IMP biosynthetic process; ATP binding; cytoplasm; identical protein binding; nucleus; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; response to drug | GO:0006189; GO:0005524; GO:0005737; GO:0042802; GO:0005634; [NAME]; GO:0042493 | 4932 | False | False | False | True | 2cnqA01 2cnuA01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -336.310886682 | -335.593091305
5275 | 2.66 | P43405 | KSYK_HUMAN | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) | SYK | Homo sapiens (Human) | 112 | 635 | no_data | Protein kinase superfamily; [NAME] protein kinase family; SYK/ZAP-70 subfamily | no_data | 3D-structure; ATP-binding; Alternative splicing; [NAME] proteome; Host-virus interaction; [NAME]; Nucleotide-binding; [NAME]; Polymorphism; Repeat; SH2 domain; Transferase; Tyrosine-protein kinase; [NAME] conjugation | P20273; P30273; P05107 | Active site (1); Alternative sequence (1); Beta strand (16); Binding site (1); Chain (1); Domain (3); [NAME] (14); Modified residue (14); Natural variant (1); Nucleotide binding (1); Region (1); [NAME] conflict (2); Turn (1) | IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; [NAME]; IPR020635; IPR020685; IPR008266 | 2.7.10.2 | ATP binding; T cell receptor complex; cell proliferation; cytoplasm; [NAME]; integrin-mediated signaling pathway; interspecies interaction between organisms; [NAME] adhesion; neutrophil chemotaxis; non-membrane spanning protein tyrosine kinase activity; organ morphogenesis; protein complex assembly | GO:0005524; GO:0042101; GO:0008283; GO:0005737; GO:0005178; GO:0007229; GO:0044419; GO:0007159; GO:0030593; GO:0004715; GO:0009887; GO:0006461 | 9606 | False | False | False | False | 1csyA00 1cszA00 | 100 | SOLUTION NMR | SOLUTION NMR | -256.873422362 | -257.615764925
824 | 5.29 | P62799 | H4_XENLA | Histone H4 | no_data | [NAME] laevis (African clawed frog) | 82 | 103 | Nucleus. | Histone H4 family | no_data | 3D-structure; Acetylation; Chromosomal protein; Citrullination; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; [NAME]; [NAME]; [NAME] conjugation | no_data | Beta strand (2); Chain (1); Cross-link (1); DNA binding (1); [NAME] (4); Initiator methionine (1); Modified residue (19) | IPR009072; IPR007125; [NAME]; IPR019809 | no_data | DNA binding; nucleosome; nucleosome assembly; nucleus | GO:0003677; GO:0000786; GO:0006334; GO:0005634 | 8355 | True | True | True | True | 2hueC00 1p3lF00 | 98.7952 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -237.497785585 | -238.048845645
5024 | 3.99 | P12676 | CHOD_STRS0 | Cholesterol oxidase (CHOD) (EC 1.1.3.6) | choA | Streptomyces sp. (strain SA-COO) | 159 | 546 | Secreted. | GMC oxidoreductase family | Steroid metabolism; cholesterol metabolism. | 3D-structure; Cholesterol metabolism; FAD; [NAME]; Lipid metabolism; Oxidoreductase; Secreted; Signal; Steroid metabolism | no_data | Active site (2); Beta strand (23); Chain (1); [NAME] (19); Mutagenesis (2); Nucleotide binding (1); Signal peptide (1); Turn (4) | IPR000172; IPR007867; [NAME]; IPR017909 | 1.1.3.6 | FAD binding; [NAME] process; cholesterol oxidase activity; extracellular region; oxidation reduction | GO:0050660; GO:0008203; GO:0016995; GO:0005576; GO:0055114 | 74576 | True | False | False | True | 1n4wA02 2gewA02 | 98.7421 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -484.025194765 | -482.925420985
5248 | 2.45 | P05100 | 3MG1_ECOLI | DNA-3-methyladenine glycosylase 1 (EC 3.2.2.20) (DNA-3-methyladenine glycosylase I) (3-methyladenine-DNA glycosylase I; constitutive) (TAG I) (DNA-3-methyladenine glycosidase I) | tag b3549 JW3518 | Escherichia coli (strain K12) | 187 | 187 | no_data | no_data | no_data | 3D-structure; [NAME] proteome; DNA damage; DNA repair; Direct protein sequencing; [NAME]; Metal-binding; Zinc | P0AFG8 | Beta strand (3); Chain (1); [NAME] (10); Metal binding (4); Turn (2) | IPR005019; IPR011257; IPR004597 | 3.2.2.20 | DNA-3-methyladenine glycosylase I activity; base-excision repair; metal ion binding; protein binding | GO:0008725; GO:0006284; GO:0046872; GO:0005515 | 83333 | False | False | False | False | 1lmzA00 1p7mA00 | 100 | SOLUTION NMR | SOLUTION NMR | -563.513494539 | -564.939407394
6990 | 2.62 | P0AFJ5 | PHOB_ECOLI | Phosphate regulon transcriptional regulatory protein phoB | phoB b0399 JW0389 | Escherichia coli (strain K12) | 105 | 229 | Cytoplasm. | no_data | no_data | 3D-structure; Activator; [NAME] proteome; Cytoplasm; DNA-binding; Phosphate transport; [NAME]; Transcription; Transcription regulation; Transport; Two-component regulatory system | P60624 | Beta strand (13); Chain (1); Domain (1); [NAME] (10); Modified residue (1); Turn (3) | IPR011006; IPR001867; IPR011879; IPR001789; IPR011991 | no_data | DNA binding; cytoplasm; phosphate transport; protein binding; regulation of transcription; DNA-dependent; transcription; two-component response regulator activity; two-component signal transduction system (phosphorelay) | GO:0003677; GO:0005737; GO:0006817; GO:0005515; GO:0006355; GO:0006350; GO:0000156; GO:0000160 | 83333 | False | False | True | True | 1qqiA00 2z33A00 | 100 | SOLUTION NMR | SOLUTION NMR | -315.283699933 | -314.439514284
525 | 6.71 | P56210 | RL11_BACST | 50S ribosomal protein L11 (Fragment) | rplK | Bacillus stearothermophilus (Geobacillus stearothermophilus) | 76 | 133 | no_data | Ribosomal protein [NAME] family | no_data | 3D-structure; Direct protein sequencing; Methylation; RNA-binding; [NAME]; Ribosomal protein; rRNA-binding | no_data | Beta strand (2); Chain (1); [NAME] (4); Non-terminal residue (1); Turn (1) | IPR000911; IPR006519; IPR020783; IPR020785; IPR020784 | no_data | rRNA binding; ribosome; structural constituent of ribosome; translation | GO:0019843; GO:0005840; GO:0003735; GO:0006412 | 1422 | True | False | False | False | 1foxA00 2fowA00 | 100 | SOLUTION NMR | SOLUTION NMR | -203.306666946 | -203.971655731
6719 | 4.7 | P16233 | LIPP_HUMAN | Pancreatic triacylglycerol lipase (Pancreatic lipase) (PL) (EC 3.1.1.3) | PNLIP | Homo sapiens (Human) | 338 | 465 | Secreted. | AB hydrolase superfamily; [NAME] family | no_data | 3D-structure; [NAME] proteome; Disulfide bond; [NAME]; Hydrolase; Lipid degradation; Secreted; Signal | no_data | Active site (3); Beta strand (24); Chain (1); Disulfide bond (6); Domain (1); Glycosylation (1); [NAME] (12); Signal peptide (1); Turn (9) | IPR000734; IPR008976; IPR013818; IPR002331; IPR001024; IPR016272 | 3.1.1.3 | lipid catabolic process; triglyceride lipase activity | GO:0016042; GO:0004806 | 9606 | False | True | False | False | 1lpbB01 1n8sA01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1089.51699819 | -1086.46671331
4349 | 3.02 | P09546 | PUTA_ECOLI | Bifunctional protein putA [Includes: Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase); Delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase) (EC 1.5.1.12)] | putA poaA b1014 JW0999 | Escherichia coli (strain K12) | 426 | 1320 | no_data | Proline dehydrogenase family; [NAME] dehydrogenase family | Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2. Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. | 3D-structure; [NAME] proteome; DNA-binding; FAD; [NAME]; Multifunctional enzyme; NAD; Oxidoreductase; Proline metabolism; Repressor; Transcription; Transcription regulation | P63389 | Active site (2); Beta strand (11); Chain (1); [NAME] (33); Region (2); [NAME] conflict (1); Turn (10) | IPR016161; IPR016160; IPR016162; IPR015590; IPR005933; IPR002872 | 1.5.99.8; 1.5.1.12 | 1-pyrroline-5-carboxylate dehydrogenase activity; FAD binding; glutamate biosynthetic process; oxidation reduction; proline biosynthetic process; proline catabolic process to glutamate; proline dehydrogenase activity; promoter binding; protein binding; regulation of transcription; specific transcriptional repressor activity; transcription; transcription factor activity | GO:0003842; GO:0050660; GO:0006537; GO:0055114; GO:0006561; GO:0010133; GO:0004657; GO:0010843; GO:0005515; GO:0045449; GO:0016566; GO:0006350; GO:0003700 | 83333 | False | False | False | False | 1tiwA01 1tj0A01 | 99.3039 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1485.18073266 | -1481.23158376
4014 | 2.99 | [NAME] | PYR5_HUMAN | Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)] | UMPS OK/SW-cl.21 | Homo sapiens (Human) | 257 | 480 | no_data | Purine/pyrimidine phosphoribosyltransferase family; OMP decarboxylase family | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. | 3D-structure; Acetylation; Alternative splicing; [NAME] proteome; Decarboxylase; Disease mutation; Glycosyltransferase; Lyase; Multifunctional enzyme; [NAME]; Polymorphism; Pyrimidine biosynthesis; Transferase | no_data | Active site (3); Alternative sequence (1); Beta strand (9); Chain (1); Erroneous termination (1); [NAME] (13); Initiator methionine (1); Modified residue (4); Mutagenesis (1); Natural variant (6); Region (3); [NAME] conflict (2); Turn (3) | IPR013785; IPR014732; IPR018089; [NAME]; IPR004467; IPR000836; IPR011060 | 2.4.2.10; 4.1.1.23 | de novo' pyrimidine base biosynthetic process; UMP biosynthetic process; cytoplasm; nucleus; orotate phosphoribosyltransferase activity; orotidine-5'-phosphate decarboxylase activity | GO:0006207; GO:0006222; GO:0005737; GO:0005634; GO:0004588; GO:0004590 | 9606 | False | False | False | False | 2qcfA00 2qcmA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -892.9197852 | -890.372168905
257 | 10.59 | P98170 | [NAME] | Baculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3 ubiquitin-protein ligase XIAP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) ([NAME]) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (ILP) (hILP) | XIAP API3 BIRC4 IAP3 | Homo sapiens (Human) | 117 | 497 | Cytoplasm. | IAP family | no_data | 3D-structure; Apoptosis; Complete proteome; Cytoplasm; Ligase; Metal-binding; [NAME]; Polymorphism; [NAME] inhibitor; Repeat; Thiol protease inhibitor; [NAME] conjugation; [NAME] conjugation pathway; Zinc; Zinc-finger | P55211; Q9NR28; O43464; Q9UHD2; P51668; P62837; P61077; P51965; P61088 | Beta strand (7); Chain (1); [NAME] (10); Metal binding (4); Modified residue (2); Mutagenesis (20); Natural variant (4); Region (1); Repeat (3); [NAME] conflict (1); Turn (4); Zinc finger (1) | IPR001370; IPR001841 | 6.3.2.- | anti-apoptosis; apoptosis; caspase inhibitor activity; cytosol; ligase activity; protein binding; response to DNA damage stimulus; zinc ion binding | GO:0006916; GO:0006915; GO:0043027; GO:0005829; GO:0016874; GO:0005515; GO:0006974; GO:0008270 | 9606 | False | False | False | False | 1f9xA00 1tfqA00 | 100 | SOLUTION NMR | SOLUTION NMR | -277.478124817 | -276.315536865
2132 | 3.19 | P84751 | Q6PJF1_HUMAN | Ig heavy chain Mem5 | no_data | no_data | 129 | no_data | no_data | no_data | no_data | no_data | no_data | no_data | no_data | no_data | no_data | no_data | no_data | False | True | True | True | 1rhhD01 2b4cH01 | 99.2308 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -411.157477046 | -409.872016138
6022 | 2.61 | Q5SL87 | RUVB_THET8 | Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-) | ruvB TTHA0406 | [NAME] thermophilus (strain HB8 / ATCC 27634 / DSM 579) | 164 | 324 | no_data | [NAME] family | no_data | 3D-structure; ATP-binding; [NAME] proteome; DNA damage; DNA recombination; DNA repair; Helicase; [NAME]; Nucleotide-binding; SOS response | Q9F1Q3 | Beta strand (10); Chain (1); [NAME] (13); Nucleotide binding (1); Turn (8) | IPR003593; IPR004605; IPR008823; IPR008824; IPR011991 | 3.6.1.- | ATP binding; DNA binding; DNA recombination; DNA repair; SOS response; four-way junction helicase activity; protein binding | GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0009432; GO:0009378; GO:0005515 | 300852 | True | False | True | False | 1hqcA01 1ixrC01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -473.505645862 | -475.323140345
4855 | 2.24 | P03051 | ROP_ECOLX | Regulatory protein rop (RNA one modulator) (ROM) | rop | Escherichia coli | 56 | 63 | no_data | no_data | no_data | 3D-structure; [NAME]; Transcription; Transcription regulation | no_data | Chain (1); [NAME] (2) | IPR000769 | no_data | regulation of transcription; transcription | GO:0045449; GO:0006350 | 562 | False | False | False | True | 1b6qA00 1gmgA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -187.170360598 | -187.810990854
1012 | 2.25 | P63159 | HMGB1_RAT | High mobility group protein B1 (High mobility group protein 1) (HMG-1) (Amphoterin) (Heparin-binding protein p30) | Hmgb1 Hmg-1 Hmg1 | Rattus norvegicus (Rat) | 77 | 215 | Nucleus. Cytoplasm. | HMGB family | no_data | 3D-structure; Acetylation; Chromosomal protein; Cytoplasm; DNA-binding; Direct protein sequencing; Heparin-binding; Isopeptide bond; [NAME]; [NAME]; Repeat; [NAME] conjugation | no_data | Chain (1); Compositional bias (1); Cross-link (1); DNA binding (2); [NAME] (7); Initiator methionine (1); Modified residue (4); Turn (1) | IPR017967; IPR000910; IPR000135; IPR009071 | no_data | 5S rRNA binding; DNA bending activity; DNA geometric change; RAGE receptor binding; [NAME] reorganization; bent DNA binding; cell morphogenesis; cellular response to interleukin-1; chemotaxis; chromosome; circadian rhythm; crossed form four-way junction DNA binding; cytokine activity; cytoplasm; double-stranded DNA binding; extracellular space; glycolipid binding; heparin binding; induction of positive chemotaxis; male-specific defense response to bacterium; myoblast proliferation; negative regulation of DNA replication; neuron projection development; nucleus; open form four-way junction DNA binding; positive regulation of mesenchymal cell proliferation; positive regulation of mitotic cell cycle; positive regulation of myeloid cell apoptosis; positive regulation of myoblast differentiation; positive regulation of neuron projection development; positive regulation of smooth muscle cell migration; protein dimerization activity; regulation of inflammatory response; response to drug; response to glucose stimulus; response to heat; response to insulin stimulus; response to interferon-gamma; response to lipopolysaccharide; single-stranded DNA binding | GO:0008097; GO:0008301; GO:0032392; GO:0050786; GO:0031532; GO:0003681; GO:0000902; GO:0071347; GO:0006935; GO:0005694; GO:0007623; [NAME]; GO:0005125; GO:0005737; [NAME]; GO:0005615; GO:0051861; GO:0008201; GO:0050930; GO:0050831; GO:0051450; GO:0008156; GO:0031175; GO:0005634; GO:0000401; GO:0002053; GO:0045931; GO:0033034; GO:0045663; GO:0010976; GO:0014911; GO:0046983; GO:0050727; GO:0042493; GO:0009749; GO:0009408; GO:0032868; GO:0034341; GO:0032496; GO:0003697 | 10116 | False | False | False | False | 1hmeA00 1hmfA00 | 100 | SOLUTION NMR | SOLUTION NMR | -222.719348942 | -221.831186708
5881 | 4.31 | Q01698 | EFTU_THEAQ | Elongation factor [NAME] (EF-Tu) | tuf tufA | [NAME] aquaticus | 213 | 406 | Cytoplasm. | GTP-binding elongation factor family; EF-Tu/EF-1A subfamily | no_data | 3D-structure; Cytoplasm; Direct protein sequencing; Elongation factor; GTP-binding; Nucleotide-binding; Protein biosynthesis | no_data | Beta strand (21); Chain (1); [NAME] (11); Initiator methionine (1); Nucleotide binding (3); Turn (5) | IPR000795; IPR005225; IPR009001; IPR004161; IPR004541; IPR004160; IPR009000 | no_data | GTP binding; GTPase activity; cytoplasm; translation elongation factor activity; translational elongation | GO:0005525; GO:0003924; GO:0005737; GO:0003746; GO:0006414 | 271 | False | False | True | False | 1tuiA01 1ob5A01 | 98.5577 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -657.625230619 | -655.153904257
5888 | 4.86 | P51157 | RAB28_HUMAN | Ras-related protein Rab-28 | RAB28 | Homo sapiens (Human) | 178 | 221 | Cell membrane; Lipid-anchor; Cytoplasmic side. | Small GTPase superfamily; Rab family | no_data | 3D-structure; Alternative splicing; Cell membrane; [NAME] proteome; GTP-binding; [NAME]; Membrane; Nucleotide-binding; Prenylation | no_data | Alternative sequence (1); Beta strand (5); Chain (1); [NAME] (9); Lipidation (1); [NAME] (1); Nucleotide binding (4); [NAME] conflict (1) | IPR013753; IPR001806; IPR005225; IPR020851 | no_data | GDP binding; GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction | GO:0019003; GO:0005525; GO:0003924; GO:0005886; GO:0007264 | 9606 | False | False | False | False | 2hxsA00 2hy4A00 | 99.4382 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -573.44928544 | -575.564418166
4067 | 2.48 | Q28943 | DPYD_PIG | Dihydropyrimidine dehydrogenase [NADP+] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrouracil dehydrogenase) (Dihydrothymine dehydrogenase) | DPYD | Sus scrofa (Pig) | 306 | 1025 | Cytoplasm. | Dihydropyrimidine dehydrogenase family | Amino-acid biosynthesis; beta-alanine biosynthesis. | 3D-structure; 4Fe-4S; Acetylation; Cytoplasm; Direct protein sequencing; FAD; FMN; [NAME]; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; [NAME]; Repeat | no_data | Beta strand (34); Chain (1); Domain (3); [NAME] (46); Metal binding (8); Modified residue (2); Nucleotide binding (2); Propeptide (1); Region (1); Turn (12) | IPR017896; IPR017900; IPR000759; IPR013785; IPR012135; IPR005720; IPR013027; IPR012285; IPR009051; IPR016040 | 1.3.1.2 | de novo' pyrimidine base biosynthetic process; 4 iron; 4 sulfur cluster binding; FAD binding; FMN binding; NADP or NADPH binding; UMP biosynthetic process; dihydroorotate oxidase activity; dihydropyrimidine dehydrogenase (NADP+) activity; electron carrier activity; metal ion binding; oxidation reduction; protein homodimerization activity; thymidine catabolic process; uracil catabolic process | GO:0006207; GO:0051539; GO:0050660; GO:0010181; GO:0050661; GO:0006222; GO:0004158; GO:0017113; GO:0009055; GO:0046872; GO:0055114; GO:0042803; GO:0006214; GO:0006212 | 9823 | False | False | False | True | 1h7wA05 1gthA05 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1039.15518118 | -1043.11785712
581 | 2.49 | O75400 | PR40A_HUMAN | Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (Huntingtin-interacting protein A) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Fas ligand-associated factor 1) (Renal carcinoma antigen NY-REN-6) | PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225 | Homo sapiens (Human) | 69 | 957 | [NAME] speckle. | PRPF40 family | no_data | 3D-structure; Acetylation; Alternative splicing; [NAME] proteome; [NAME]; [NAME]; Repeat; mRNA processing; mRNA splicing | Q12873; Q15287 | Alternative sequence (3); Beta strand (3); Chain (1); Domain (7); Erroneous initiation (3); Frameshift (2); [NAME] (8); Modified residue (16); Sequence caution (2); [NAME] conflict (4); Turn (2) | IPR002713; IPR001202 | no_data | RNA splicing; mRNA processing; nuclear speck; protein binding | GO:0008380; GO:0006397; GO:0016607; GO:0005515 | 9606 | False | False | False | False | 1uzcA00 1h40A00 | 100 | SOLUTION NMR | NMR, 25 STRUCTURES | -206.891577496 | -207.789097043
2510 | 3.1 | P12319 | FCERA_HUMAN | High affinity immunoglobulin epsilon receptor subunit alpha (IgE Fc receptor subunit alpha) (Fc-epsilon RI-alpha) (FcERI) | FCER1A FCE1A | Homo sapiens (Human) | 77 | 257 | Cell membrane; Single-pass type I membrane protein. | no_data | no_data | 3D-structure; Cell membrane; [NAME] proteome; Direct protein sequencing; Disulfide bond; [NAME]; IgE-binding protein; Immunoglobulin domain; Membrane; Polymorphism; Receptor; Repeat; Signal; [NAME] | no_data | Beta strand (15); Chain (1); Disulfide bond (2); Domain (2); Glycosylation (7); [NAME] (3); Natural variant (2); Signal peptide (1); Topological domain (2); [NAME] (1) | IPR007110; IPR013783; IPR003599; [NAME]; [NAME] | no_data | integral to plasma membrane | GO:0005887 | 9606 | True | False | True | True | 1j86A01 1j88A01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -220.662430196 | -219.646056581
3051 | 2.31 | Q8GSD2 | Q8GSD2_PTEAG | [NAME] (Fragment) | no_data | Pterocarpus angolensis (Kiaat tree) (Bleedwood tree) | 240 | 260 | no_data | no_data | no_data | Lectin; Signal | no_data | Chain (1); Non-terminal residue (1); Signal peptide (1) | IPR008985; IPR013320; IPR016363; IPR000985; IPR001220; IPR019825 | no_data | sugar binding | GO:0005529 | 182271 | False | False | False | True | 2areA00 1s1aA00 | 99.5851 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -778.483979633 | -781.660769782
971 | 2.9 | O14763 | TR10B_HUMAN | Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262) | TNFRSF10B DR5 KILLER TRAILR2 TRICK2 ZTNFR9 UNQ160/PRO186 | Homo sapiens (Human) | 40 | 440 | Membrane; Single-pass type I membrane protein. | no_data | no_data | 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Direct protein sequencing; Disulfide bond; [NAME]; Polymorphism; Receptor; Repeat; Signal; [NAME] | Q96P48 | Alternative sequence (2); Beta strand (11); Chain (1); Compositional bias (1); Disulfide bond (7); Domain (1); Natural variant (3); Repeat (4); [NAME] conflict (2); Signal peptide (1); Topological domain (2); [NAME] (1); Turn (1) | IPR000488; IPR011029; IPR017301; IPR020465; IPR001368 | no_data | TRAIL binding; activation of NF-kappaB-inducing kinase activity; activation of caspase activity; activation of pro-apoptotic gene products; caspase activator activity; cell surface receptor linked signaling pathway; induction of apoptosis via death domain receptors; integral to membrane; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; receptor activity | GO:0045569; GO:0007250; GO:0006919; GO:0008633; GO:0008656; GO:0007166; GO:0008625; GO:0016021; GO:0005886; GO:0043123; GO:0004872 | 9606 | False | True | True | True | 2h9gR02 1za3R02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -77.2932283746 | -77.826342242
6496 | 2.09 | Q60099 | HAD_XANAU | (S)-2-haloacid dehalogenase (EC 3.8.1.2) (2-haloalkanoic acid dehalogenase) (L-2-haloacid dehalogenase) (Halocarboxylic acid halidohydrolase) | dhlB | Xanthobacter autotrophicus | 166 | 253 | no_data | HAD-like hydrolase superfamily; S-2-haloalkanoic acid dehalogenase family | no_data | 3D-structure; Direct protein sequencing; [NAME] | no_data | Active site (1); Beta strand (6); Chain (1); [NAME] (17); [NAME] conflict (2); Turn (1) | IPR005834; IPR006388; IPR006328; IPR005833 | 3.8.1.2 | (S)-2-haloacid dehalogenase activity; metabolic process | GO:0018784; GO:0008152 | 280 | False | True | False | False | 1qq5A01 1aq6A01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -530.586071324 | -532.872509492
2810 | 2.56 | P43214 | [NAME] | Pollen allergen Phl p 2 (Allergen Phl p II) (allergen Phl p 2) | PHLPII | Phleum pratense (Common timothy) | 94 | 122 | Secreted. | [NAME] family; [NAME] B subfamily | no_data | 3D-structure; Allergen; Secreted; Signal | no_data | Beta strand (6); Chain (1); Domain (1); Signal peptide (1) | IPR005453; IPR007117 | no_data | extracellular region | GO:0005576 | 15957 | False | False | True | True | 1whoA00 1whpA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -286.782380087 | -288.124757784
2416 | 2.25 | Q569F4 | Q569F4_HUMAN | IGHG1 protein. | 0 | 0 | 120 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | False | True | True | True | 2fjfB01 2fjgB01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -380.962828313 | -382.676749001
5891 | 7.2 | P69441 | KAD_ECOLI | Adenylate [NAME] (AK) (EC 2.7.4.3) (ATP-AMP transphosphorylase) | adk dnaW plsA b0474 JW0463 | Escherichia coli (strain K12) | 214 | 214 | Cytoplasm. | Adenylate [NAME] family | Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. | 3D-structure; ATP-binding; Acetylation; [NAME] proteome; Cytoplasm; Direct protein sequencing; [NAME]; Nucleotide biosynthesis; Nucleotide-binding; Transferase | P0A8T7; P77806 | Beta strand (7); Chain (1); Erroneous initiation (1); [NAME] (12); Modified residue (1); Mutagenesis (3); Nucleotide binding (2); Region (1); Turn (5) | IPR006259; IPR000850; IPR007862 | 2.7.4.3 | AMP binding; ATP binding; adenylate kinase activity; cytoplasm; magnesium ion binding; protein binding; purine ribonucleotide biosynthetic process; purine ribonucleotide interconversion | GO:0016208; GO:0005524; GO:0004017; GO:0005737; GO:0000287; GO:0005515; GO:0009152; GO:0015951 | 83333 | False | True | True | False | 4akeA00 2eckA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -724.590041686 | -727.682400355
818 | 4.53 | O96910 | ATT_APLCA | Attractin | ATT | Aplysia californica (California sea hare) | 58 | 76 | Secreted. | no_data | no_data | 3D-structure; Direct protein sequencing; Disulfide bond; [NAME]; Pheromone; Secreted; Signal | no_data | Beta strand (2); Chain (1); Disulfide bond (3); Glycosylation (1); [NAME] (4); Mass spectrometry (1); Signal peptide (1); Turn (2) | IPR012529 | no_data | extracellular region; mating pheromone activity; sexual reproduction | GO:0005576; GO:0000772; GO:0019953 | 6500 | False | False | False | False | 1t50A00 1nj7A00 | 100 | SOLUTION NMR | NMR, 20 STRUCTURES | -123.534374362 | -124.409592793
755 | 2.7 | P05231 | IL6_HUMAN | Interleukin-6 (IL-6) (B-cell stimulatory factor 2) ([NAME]) (Interferon beta-2) (IFN-beta-2) (Hybridoma growth factor) (CTL differentiation factor) (CDF) | IL6 IFNB2 | Homo sapiens (Human) | 157 | 212 | Secreted. | IL-6 superfamily | no_data | 3D-structure; Acute phase; [NAME] proteome; Cytokine; Direct protein sequencing; Disulfide bond; [NAME]; Growth factor; Polymorphism; Secreted; Signal | no_data | Beta strand (1); Chain (1); Disulfide bond (2); Glycosylation (1); [NAME] (6); Mutagenesis (5); Natural variant (3); Signal peptide (1) | IPR009079; IPR003573; IPR003574 | no_data | acute-phase response; cytokine activity; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; defense response to virus; endocrine pancreas development; extracellular space; glucagon secretion; growth factor activity; hepatic immune response; humoral immune response; interleukin-6 receptor binding; interleukin-6 receptor complex; interleukin-6-mediated signaling pathway; [NAME] chemotaxis; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of chemokine biosynthetic process; negative regulation of collagen biosynthetic process; neuron projection development; neutrophil apoptosis; neutrophil mediated immunity; platelet activation; positive regulation of B cell activation; positive regulation of MAPKKK cascade; positive regulation of T cell proliferation; positive regulation of acute inflammatory response; positive regulation of anti-apoptosis; positive regulation of chemokine production; positive regulation of gene-specific transcription; positive regulation of immunoglobulin secretion; positive regulation of interleukin-6 production; positive regulation of leukocyte chemotaxis; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of translation; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of angiogenesis; regulation of vascular endothelial growth factor production; response to glucocorticoid stimulus; response to peptidoglycan | GO:0006953; GO:0005125; GO:0050829; [NAME]; GO:0051607; GO:0031018; GO:0005615; GO:0070091; GO:0008083; GO:0002384; GO:0006959; [NAME]; [NAME]; GO:0070102; GO:0002548; GO:0043066; GO:0008285; GO:0045079; GO:0032966; GO:0031175; GO:0001781; GO:0002446; GO:0030168; GO:0050871; GO:0043410; GO:0042102; GO:0002675; GO:0045768; GO:0032722; GO:0043193; GO:0051024; GO:0032755; GO:0002690; GO:0045669; [NAME]; GO:0048661; GO:0051091; GO:0045944; GO:0045727; GO:0042517; GO:0045765; GO:0010574; GO:0051384; GO:0032494 | 9606 | False | True | True | True | 1p9mB00 2il6A00 | 98.1928 | X-RAY DIFFRACTION | SOLUTION NMR | -498.677203263 | -501.122967089
4465 | 2.65 | P63319 | KPCG_RAT | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Prkcg Pkcc Pkcg Prkcc | Rattus norvegicus (Rat) | 66 | 697 | no_data | Protein kinase superfamily; [NAME]/Thr protein kinase family; PKC subfamily | no_data | 3D-structure; ATP-binding; Acetylation; Calcium; Kinase; Metal-binding; Nucleotide-binding; [NAME]; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger | no_data | Active site (1); Beta strand (2); Binding site (1); Chain (1); Domain (3); Metal binding (14); Modified residue (10); Nucleotide binding (1); Turn (3); Zinc finger (2) | IPR000961; IPR000008; [NAME]; IPR018029; IPR020477; IPR020454; IPR011009; IPR015745; IPR017892; IPR002219; IPR000719; IPR017441; IPR014375; IPR017442; IPR008271; IPR002290 | 2.7.11.13 | ATP binding; cytosol; learning or memory; protein amino acid phosphorylation; protein kinase C activity; synaptic transmission; synaptosome; zinc ion binding | GO:0005524; GO:0005829; GO:0007611; GO:0006468; GO:0004697; GO:0007268; GO:0019717; GO:0008270 | 10116 | False | False | False | False | 1tbnA00 1tboA00 | 100 | SOLUTION NMR | SOLUTION NMR | -131.319423596 | -132.362767393
1171 | 2.06 | B2J9B4 | 0 | putative gamma-d-glutamyl-l-diamino acid endopeptidase (npun_r0659) | 0 | Nostoc punctiforme PCC 73102 | 74 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | False | False | False | False | 2evrA01 2fg0A01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -222.591522332 | -223.793276789
1758 | 2.19 | P27694 | RFA1_HUMAN | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) | RPA1 REPA1 RPA70 | Homo sapiens (Human) | 124 | 616 | Nucleus. | Replication factor A protein 1 family | no_data | 3D-structure; Acetylation; [NAME] proteome; DNA replication; DNA-binding; Direct protein sequencing; Metal-binding; [NAME]; [NAME]; Polymorphism; Zinc; Zinc-finger | [NAME]; P04637; [NAME] | Beta strand (16); Chain (1); Erroneous initiation (1); [NAME] (8); Initiator methionine (1); Modified residue (6); Natural variant (1); Turn (4); Zinc finger (1) | IPR012340; IPR016027; IPR004365; IPR007199; IPR013955; IPR004591 | no_data | DNA replication factor A complex; DNA-dependent DNA replication; PML body; [NAME]; cytoplasm; metal ion binding; nucleotide-excision repair; DNA damage removal; nucleotide-excision repair; DNA gap filling; protein binding; single-stranded DNA binding | GO:0005662; [NAME]; GO:0016605; GO:0015629; GO:0005737; GO:0046872; GO:0000718; GO:0006297; GO:0005515; GO:0003697 | 9606 | False | False | False | True | 1jmcA02 1fguA02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -377.73628059 | -379.816413596
198 | 2.3 | P00439 | PH4H_HUMAN | Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) | PAH | Homo sapiens (Human) | 307 | 452 | no_data | Biopterin-dependent aromatic amino acid hydroxylase family | Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. | 3D-structure; Allosteric enzyme; [NAME] proteome; Direct protein sequencing; Disease mutation; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Phenylalanine catabolism; Phenylketonuria; [NAME]; Polymorphism | no_data | Beta strand (9); Chain (1); Domain (1); [NAME] (17); Metal binding (3); Modified residue (1); Mutagenesis (1); Natural variant (196); [NAME] conflict (1); Turn (4) | IPR002912; IPR001273; IPR018301; IPR019774; IPR005961; IPR019773 | 1.14.16.1 | L-phenylalanine catabolic process; amino acid binding; catecholamine biosynthetic process; iron ion binding; neurotransmitter biosynthetic process; oxidation reduction; phenylalanine 4-monooxygenase activity | GO:0006559; GO:0016597; GO:0042423; GO:0005506; GO:0042136; GO:0055114; GO:0004505 | 9606 | False | False | True | False | 1j8tA00 1mmtA00 | 99.6753 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -996.94085517 | -1002.0968148
6406 | 2.24 | Q57366 | DMSA_RHOSH | Dimethyl sulfoxide reductase (DMSO reductase) (DMSOR) (EC 1.8.99.-) | dmsA dsrA | Rhodobacter sphaeroides ([NAME] sphaeroides) | 209 | 822 | Periplasm. | Prokaryotic molybdopterin-containing oxidoreductase family | no_data | 3D-structure; Direct protein sequencing; Molybdenum; Oxidoreductase; Periplasm; Signal | no_data | Active site (1); Beta strand (31); Chain (1); [NAME] (36); [NAME] conflict (11); Signal peptide (1); Turn (9) | IPR009010; IPR006658; IPR006657; IPR006656; IPR006655; [NAME]; IPR017909 | 1.8.99.- | electron carrier activity; molybdenum ion binding; oxidation reduction; oxidoreductase activity; periplasmic space | GO:0009055; GO:0030151; GO:0055114; GO:0016491; GO:0042597 | 1063 | False | False | False | False | 1eu1A01 1cxsA01 | 98.5646 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -683.391817991 | -687.02148412
1445 | 2.6 | [NAME] | METJ_ECOLI | Met repressor (Met regulon regulatory protein metJ) | metJ b3938 JW3909 | Escherichia coli (strain K12) | 104 | 105 | Cytoplasm. | MetJ family | no_data | 3D-structure; Amino-acid biosynthesis; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; [NAME] biosynthesis; Repressor; Transcription; Transcription regulation | no_data | Beta strand (2); Chain (1); [NAME] (4); Initiator methionine (1); Natural variant (2) | IPR002084; IPR010985 | no_data | cytoplasm; methionine biosynthetic process; negative regulation of transcription; DNA-dependent; transcription; transcription factor activity; transcription repressor activity | GO:0005737; GO:0009086; GO:0045892; GO:0006350; GO:0003700; GO:0016564 | 83333 | False | True | True | False | 1mjoA00 1mjmA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -299.716023876 | -301.532822007
6739 | 8.64 | Q7SIG1 | Q7SIG1_ALIAC | Hydrolase | no_data | Alicyclobacillus acidocaldarius (Bacillus acidocaldarius) | 308 | 310 | no_data | no_data | no_data | 3D-structure | no_data | no_data | no_data | no_data | no_data | no_data | 1388 | False | False | False | True | 1u4nA00 1qz3A00 | 99.6764 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1040.07227781 | -1034.62666931
5276 | 4.34 | O89100 | GRAP2_MOUSE | GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor-binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID) | Grap2 Gads Grb2l Grid Mona | Mus musculus (Mouse) | 100 | 322 | no_data | GRB2/sem-5/DRK family | no_data | 3D-structure; Acetylation; [NAME]; Repeat; SH2 domain; SH3 domain | no_data | Beta strand (11); Chain (1); Domain (3); [NAME] (3); Modified residue (2); Turn (1) | IPR000980; IPR001452; IPR020473 | no_data | protein binding | GO:0005515 | 10090 | False | False | False | False | 1r1pB00 1r1sG00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -278.295667173 | -276.440926483
1455 | 2.23 | P0A809 | RUVA_ECOLI | Holliday junction ATP-dependent DNA helicase ruvA (EC 3.6.1.-) | ruvA b1861 JW1850 | Escherichia coli (strain K12) | 76 | 203 | no_data | RuvA family | no_data | 3D-structure; ATP-binding; [NAME] proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; [NAME]; Nucleotide-binding; SOS response | no_data | Beta strand (6); Chain (1); [NAME] (10); [NAME] conflict (1); Turn (1) | [NAME]; [NAME]; IPR003583; IPR012340; IPR016027; IPR000085; IPR010994 | 3.6.1.- | ATP binding; DNA binding; DNA recombination; DNA repair; Holliday junction helicase complex; SOS response; four-way junction helicase activity | GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0009379; GO:0009432; GO:0009378 | 83333 | False | False | True | True | 1cukA02 1c7yA02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -238.782377277 | -237.338728701
3184 | 5.27 | P22216 | RAD53_YEAST | Serine/threonine-protein kinase RAD53 (EC 2.7.11.1) (Serine-protein kinase 1) (CHK2 homolog) | RAD53 MEC2 SAD1 [NAME] P2588 | Saccharomyces cerevisiae ([NAME]'s yeast) | 127 | 821 | Nucleus. | Protein kinase superfamily; CAMK Ser/Thr protein kinase family; CHK2 subfamily | no_data | 3D-structure; ATP-binding; Cell cycle; [NAME] proteome; DNA damage; [NAME]; Nucleotide-binding; [NAME]; [NAME]; Repeat; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase | [NAME]; P34217 | Active site (1); Beta strand (21); Binding site (1); Chain (1); Domain (3); [NAME] (6); Modified residue (21); Nucleotide binding (1); [NAME] conflict (1); Turn (1) | IPR020636; IPR000253; IPR011009; IPR000719; IPR017441; IPR017442; IPR008271; IPR020648; IPR002290; IPR016256; IPR008984 | 2.7.11.1 | ATP binding; DNA repair; DNA replication initiation; DNA replication origin binding; cell cycle; deoxyribonucleoside triphosphate biosynthetic process; nucleus; protein amino acid phosphorylation; protein binding; protein localization; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity | GO:0005524; GO:0006281; GO:0006270; GO:0003688; GO:0007049; GO:0009202; GO:0005634; GO:0006468; GO:0005515; GO:0008104; GO:0004674; GO:0004712; GO:0004713 | 4932 | False | False | False | True | 1j4oA00 1k3qA00 | 100 | SOLUTION NMR | SOLUTION NMR | -431.963169292 | -434.492230131
4836 | 2.37 | Q9UGP5 | DPOLL_HUMAN | DNA polymerase lambda ([NAME]) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase kappa) (DNA polymerase beta-2) ([NAME]) | POLL | Homo sapiens (Human) | 67 | 575 | Nucleus. | DNA polymerase type-X family | no_data | 3D-structure; [NAME] proteome; DNA damage; DNA repair; DNA replication; DNA synthesis; DNA-binding; DNA-directed DNA polymerase; Lyase; Manganese; Metal-binding; Nucleotidyltransferase; [NAME]; [NAME]; Polymorphism; Transferase | no_data | Active site (1); Beta strand (13); Chain (1); Domain (1); Erroneous initiation (1); [NAME] (24); Metal binding (3); Modified residue (1); Mutagenesis (3); Natural variant (2); Region (4); [NAME] conflict (2); Turn (2) | IPR001357; IPR002054; IPR002008; IPR010996; IPR022312; IPR019843; [NAME]; IPR003583 | 2.7.7.7; 4.2.99.- | DNA binding; DNA replication; DNA-directed DNA polymerase activity; lyase activity; metal ion binding; nucleotide-excision repair; nucleus; somatic hypermutation of immunoglobulin genes | GO:0003677; GO:0006260; GO:0003887; GO:0016829; GO:0046872; GO:0006289; GO:0005634; GO:0016446 | 9606 | True | False | False | True | 2bcqA04 1xslA04 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -195.666059982 | -197.008916143
3276 | 2.01 | P17900 | SAP3_HUMAN | Ganglioside GM2 activator (GM2-AP) (Cerebroside sulfate activator protein) (Shingolipid activator protein 3) (SAP-3) [Cleaved into: Ganglioside GM2 activator isoform short] | GM2A | Homo sapiens (Human) | 164 | 193 | Lysosome. | no_data | no_data | 3D-structure; [NAME] proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Gangliosidosis; [NAME]; Lipid metabolism; Lysosome; Polymorphism; Signal; Sphingolipid metabolism | no_data | Beta strand (8); Chain (2); Disulfide bond (4); Erroneous initiation (1); Glycosylation (1); [NAME] (2); Natural variant (6); Propeptide (1); Signal peptide (1); Turn (2) | IPR003172 | no_data | lysosome; sphingolipid activator protein activity | GO:0005764; GO:0030290 | 9606 | False | False | False | True | 2ag4A00 1pu5A00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -475.528356775 | -472.235985843
7176 | 2.96 | P53779 | MK10_HUMAN | Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | MAPK10 JNK3 JNK3A PRKM10 | Homo sapiens (Human) | 205 | 464 | Cytoplasm. | Protein kinase superfamily; [NAME]/Thr protein kinase family; MAP kinase subfamily | no_data | 3D-structure; ATP-binding; Alternative splicing; Chromosomal rearrangement; [NAME] proteome; Cytoplasm; Direct protein sequencing; Epilepsy; [NAME]; Nucleotide-binding; [NAME]; [NAME]/threonine-protein kinase; Transferase | P49407 | Active site (1); Alternative sequence (1); Beta strand (10); Binding site (1); Chain (1); Domain (1); [NAME] (16); Mass spectrometry (1); Modified residue (4); [NAME] (1); Nucleotide binding (1); Turn (5) | IPR008351; IPR011009; IPR003527; IPR000719; IPR017442; IPR008271; IPR002290 | 2.7.11.24 | ATP binding; JNK cascade; JUN kinase activity; MAP kinase kinase activity; nucleoplasm; protein amino acid phosphorylation; protein binding | GO:0005524; GO:0007254; GO:0004705; GO:0004708; GO:0005654; GO:0006468; GO:0005515 | 9606 | False | False | False | True | 1jnkA02 1pmuA02 | 98.1395 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -653.747192818 | -657.887220798
4468 | 2.48 | P67954 | IOVO_LOPNY | Ovomucoid (Fragment) | no_data | Lophura nycthemera (Silver pheasant) | 56 | 56 | Secreted. | no_data | no_data | 3D-structure; Direct protein sequencing; Disulfide bond; [NAME]; Protease inhibitor; Repeat; Secreted; Serine protease inhibitor | no_data | Beta strand (3); Chain (1); Disulfide bond (3); Domain (1); Glycosylation (1); [NAME] (1); Non-terminal residue (2); Site (1); Turn (1) | IPR002350; IPR001239 | no_data | extracellular region; serine-type endopeptidase inhibitor activity | GO:0005576; GO:0004867 | 9046 | False | False | True | False | 2ovoA00 4ovoA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -134.596635329 | -133.45633006
6880 | 3.16 | P0AE67 | CHEY_ECOLI | Chemotaxis protein cheY | cheY b1882 JW1871 | Escherichia coli (strain K12) | 128 | 129 | Cytoplasm. | no_data | no_data | 3D-structure; Acetylation; [NAME]; [NAME] proteome; Cytoplasm; Direct protein sequencing; Flagellar rotation; Magnesium; Metal-binding; [NAME]; Two-component regulatory system | no_data | Beta strand (6); Chain (1); Domain (1); [NAME] (5); Initiator methionine (1); Mass spectrometry (2); Metal binding (4); Modified residue (3); Mutagenesis (4); [NAME] conflict (1) | IPR011006; IPR001789 | no_data | chemotaxis; ciliary or flagellar motility; cytoplasm; metal ion binding; protein amino acid acetylation; regulation of transcription; DNA-dependent; two-component response regulator activity; two-component signal transduction system (phosphorelay) | GO:0006935; GO:0001539; GO:0005737; GO:0046872; GO:0006473; GO:0006355; GO:0000156; GO:0000160 | 83333 | True | True | True | True | 3chyA00 1chnA00 | 98.4375 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -431.976352724 | -429.368644938
1817 | 2.28 | [NAME] | A3FH86_9HIV1 | Protease (Fragment) | pol | Human immunodeficiency virus 1 | 99 | 99 | no_data | no_data | no_data | Aspartyl protease; [NAME]; [NAME] | no_data | Non-terminal residue (2) | IPR018061; [NAME]; IPR021109; IPR001969; IPR009007 | no_data | aspartic-type endopeptidase activity; proteolysis | GO:0004190; GO:0006508 | 11676 | True | True | True | True | 2pc0A00 2az8A00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -282.331257135 | -280.30751778
458 | 4.84 | P68699 | ATPL_ECOLI | ATP synthase subunit c (ATP synthase F(0) sector subunit c) (F-type ATPase subunit c) (F-ATPase subunit c) (Lipid-binding protein) (Dicyclohexylcarbodiimide-binding protein) | atpE papH [NAME] | Escherichia coli (strain K12) | 79 | 79 | Cell inner membrane; Multi-pass membrane protein. | ATPase C chain family | no_data | 3D-structure; ATP synthesis; CF(0); Cell inner membrane; Cell membrane; [NAME] proteome; Direct protein sequencing; Formylation; Hydrogen ion transport; Ion transport; Lipid-binding; Membrane; [NAME]; Transport | no_data | Beta strand (1); Chain (1); [NAME] (2); Modified residue (1); Mutagenesis (4); [NAME] conflict (1); Site (1); Topological domain (3); [NAME] (2) | IPR000454; IPR005953; IPR020537; IPR002379 | no_data | ATP synthesis coupled proton transport; hydrogen ion transporting ATP synthase activity; rotational mechanism; integral to membrane; lipid binding; plasma membrane; proton-transporting ATP synthase complex; coupling factor F(o) | GO:0015986; GO:0046933; GO:0016021; GO:0008289; GO:0005886; GO:0045263 | 83333 | False | False | False | True | 1c0vA00 1c99A00 | 100 | SOLUTION NMR | SOLUTION NMR | -260.174654196 | -261.795545923
1950 | 3.29 | P02692 | FABPL_RAT | Fatty acid-binding protein; liver (Liver-type fatty acid-binding protein) (L-FABP) (Fatty acid-binding protein 1) (Squalene- and sterol-carrier protein) (SCP) (Z-protein) (p14) | Fabp1 | Rattus norvegicus (Rat) | 127 | 127 | Cytoplasm. | Calycin superfamily; Fatty-acid binding protein (FABP) family | no_data | 3D-structure; Acetylation; Cytoplasm; Direct protein sequencing; Lipid-binding; [NAME]; Transport | no_data | Beta strand (11); Binding site (3); Chain (1); [NAME] (2); Modified residue (3); Region (1) | IPR012674; IPR011038; IPR000463; IPR000566 | no_data | apical cortex; bile acid binding; cytosol; drug binding; fatty acid binding; intestinal absorption; long-chain fatty acid transport; long-chain fatty acid transporter activity; lysophospholipid transporter activity; mitosis; nucleus; peroxisomal matrix; phospholipid binding; positive regulation of cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of hydrolase activity | GO:0045179; GO:0032052; GO:0005829; GO:0008144; GO:0005504; GO:0050892; GO:0015909; GO:0005324; GO:0051978; GO:0007067; GO:0005634; GO:0005782; GO:0005543; GO:0008284; GO:0032000; GO:0051345 | 10116 | False | False | False | True | 2ju3A00 2ju7A00 | 100 | SOLUTION NMR | SOLUTION NMR | -400.625185803 | -403.281328247
1820 | 2.38 | P35963 | [NAME] | Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); [NAME] peptide p2; Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); [NAME] (EC 3.4.23.16) ([NAME]) (PR); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (p66 [NAME]); p51 RT; p15; [NAME] (IN)] | gag-pol | Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1) | 99 | 1435 | Virion. Host nucleus. Host cytoplasm. Host cell membrane; Lipid-anchor.  Virion.  Virion. Host nucleus. Host cytoplasm. | no_data | no_data | 3D-structure; AIDS; Aspartyl protease; Capsid maturation; Capsid protein; DNA integration; DNA recombination; DNA-directed DNA polymerase; Endonuclease; Host cell membrane; Host cytoplasm; Host membrane; Host nucleus; [NAME]; [NAME]; Magnesium; Membrane; Metal-binding; Multifunctional enzyme; Myristate; Nuclease; Nucleotidyltransferase; [NAME]; [NAME]; RNA-binding; RNA-directed DNA polymerase; Repeat; Ribosomal frameshifting; Transferase; Viral nucleoprotein; Virion; Zinc; Zinc-finger | no_data | Active site (1); Beta strand (7); Chain (10); DNA binding (1); Domain (4); [NAME] (6); Initiator methionine (1); Lipidation (1); Metal binding (9); Modified residue (1); [NAME] (3); [NAME] (2); Region (1); Site (12); Turn (1); Zinc finger (3) | IPR000721; IPR001037; [NAME]; [NAME]; IPR003308; IPR000071; IPR018061; [NAME]; IPR021109; IPR001969; IPR009007; IPR012337; IPR008916; IPR008919; IPR010999; IPR000477; IPR002156; IPR010659; IPR010661; IPR013084; IPR001878 | 3.4.23.16; 2.7.7.49; 2.7.7.7; 3.1.26.13 | DNA binding; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; cytosol; host cell cytoplasm; host cell nucleus; host cell plasma membrane; initiation of viral infection; integrase activity; membrane; proteolysis; provirus integration; ribonuclease H activity; structural molecule activity; viral capsid; viral procapsid maturation; zinc ion binding | GO:0003677; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0005829; GO:0030430; GO:0042025; GO:0020002; GO:0019059; GO:0008907; GO:0016020; GO:0006508; GO:0019047; GO:0004523; GO:0005198; GO:0019028; GO:0046797; GO:0008270 | 362651 | False | False | False | False | 1k6vA00 1t7jA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -276.89206751 | -274.782247576
2062 | 2.92 | P63018 | HSP7C_RAT | Heat shock cognate 71 [NAME] protein (Heat shock 70 kDa protein 8) | [NAME] | Rattus norvegicus (Rat) | 159 | 646 | Cytoplasm. Melanosome. | Heat shock protein 70 family | no_data | 3D-structure; ATP-binding; Acetylation; Chaperone; Cytoplasm; Direct protein sequencing; Nucleotide-binding; [NAME]; Stress response | no_data | Beta strand (12); Chain (1); [NAME] (6); Initiator methionine (1); Modified residue (23); Region (1); Turn (6) | IPR018181; IPR001023; IPR013126 | no_data | ATP binding; melanosome; response to stress; ribonucleoprotein complex | GO:0005524; GO:0042470; GO:0006950; GO:0030529 | 10116 | False | False | False | False | 1ckrA00 7hscA00 | 100 | SOLUTION NMR | SOLUTION NMR | -451.050023697 | -447.433846072
211 | 2.08 | P06876 | MYB_MOUSE | Transcriptional activator Myb (Proto-oncogene c-Myb) | Myb | Mus musculus (Mouse) | 46 | 636 | Nucleus. | no_data | no_data | 3D-structure; Acetylation; [NAME]; DNA-binding; [NAME]; Proto-oncogene; Repeat; Transcription; Transcription regulation; [NAME] conjugation | Q9QZR5; O54949 | Chain (1); DNA binding (3); Domain (4); [NAME] (10); Modified residue (2); Region (3); [NAME] conflict (7) | IPR015395; IPR009057; IPR012287; [NAME]; IPR014778; IPR015495; IPR001005; IPR012642 | no_data | G1/S transition of mitotic cell cycle; calcium ion transport; [NAME] development; in utero embryonic development; nucleus; protein binding; regulation of transcription; DNA-dependent; transcription; transcription factor activity | GO:0000082; GO:0006816; GO:0048566; GO:0001701; GO:0005634; GO:0005515; GO:0006355; GO:0006350; GO:0003700 | 10090 | True | False | True | True | 1mbjA00 1mbkA00 | 100 | SOLUTION NMR | SOLUTION NMR | -147.475795415 | -148.530368925
6328 | 5.38 | P56255 | PCRA_BACST | ATP-dependent DNA helicase [NAME] (EC 3.6.1.-) | [NAME] | Bacillus stearothermophilus (Geobacillus stearothermophilus) | 140 | 724 | no_data | [NAME] family; UvrD subfamily | no_data | 3D-structure; ATP-binding; DNA-binding; Helicase; [NAME]; Nucleotide-binding | no_data | Beta strand (15); Chain (1); Domain (2); [NAME] (38); Nucleotide binding (1); Turn (10) | IPR005751; IPR014017; IPR000212; IPR014016 | 3.6.1.- | ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA repair; DNA unwinding involved in replication; cytoplasm | GO:0005524; GO:0004003; GO:0003677; GO:0006281; GO:0006268; GO:0005737 | 1422 | False | True | True | True | 1pjrA04 1qhgA04 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -460.416430929 | -457.178129044
1384 | 3.64 | P35049 | TRYP_FUSOX | [NAME] (EC 3.4.21.4) | no_data | Fusarium oxysporum (Panama disease fungus) | 100 | 248 | Secreted. | [NAME] family | no_data | 3D-structure; Disulfide bond; [NAME]; [NAME]; Secreted; Serine protease; Signal; Zymogen | no_data | Active site (3); Beta strand (14); Chain (1); Disulfide bond (3); Domain (1); [NAME] (4); Propeptide (1); Signal peptide (1); Site (1); Turn (2) | IPR018114; [NAME]; IPR001314; IPR009003 | 3.4.21.4 | extracellular region; proteolysis; serine-type endopeptidase activity | GO:0005576; GO:0006508; GO:0004252 | 5507 | False | True | True | True | 1pq7A02 1pqaA02 | 99 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -302.893701913 | -300.551364976
266 | 2.25 | P13479 | IMM9_ECOLX | Colicin-E9 immunity protein (ImmE9) (Microcin-E9 immunity protein) | imm ceiE9 | Escherichia coli | 83 | 86 | no_data | Colicins ColE2/ColE8/ColE9 and pyocins S1/S2 family | no_data | 3D-structure; Bacteriocin immunity; [NAME] | P09883 | Beta strand (1); Chain (1); [NAME] (5); [NAME] conflict (1); Turn (1) | IPR000290 | no_data | bacteriocin immunity; protein binding; toxin binding | GO:0030153; GO:0005515; GO:0015643 | 562 | False | False | False | True | 1e0hA00 1imqA00 | 100 | SOLUTION NMR | SOLUTION NMR | -242.453921942 | -244.461266435
86 | 2.75 | P00183 | CPXA_PSEPU | Camphor 5-monooxygenase (EC 1.14.15.1) (Cytochrome P450-cam) (Cytochrome P450cam) | camC cyp101 | Pseudomonas putida | 405 | 415 | Cytoplasm. | Cytochrome P450 family | Terpene metabolism; (R)-camphor degradation. | 3D-structure; Cytoplasm; Direct protein sequencing; Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase | no_data | Beta strand (13); Chain (1); [NAME] (25); Initiator methionine (1); Metal binding (1); [NAME] conflict (4); Turn (6) | IPR001128; IPR002397; IPR017973; IPR017972 | 1.14.15.1 | camphor 5-monooxygenase activity; cytoplasm; electron carrier activity; heme binding; oxidation reduction | GO:0018683; GO:0005737; GO:0009055; GO:0020037; GO:0055114 | 303 | False | False | False | True | 2h7qA00 2zaxA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1361.46692812 | -1371.3035766
2626 | 2.66 | P12830 | CADH1_HUMAN | Cadherin-1 (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CAM 120/80) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | CDH1 CDHE UVO | Homo sapiens (Human) | 104 | 882 | Cell junction. Cell membrane; Single-pass type I membrane protein. | no_data | no_data | 3D-structure; Calcium; Cell adhesion; Cell junction; Cell membrane; Cleavage on pair of basic residues; [NAME] proteome; Direct protein sequencing; Disease mutation; Disulfide bond; [NAME]; [NAME]; [NAME]; Polymorphism; Repeat; Signal; [NAME] | P35222; P11362; P25146; P62136; Q15139 | Beta strand (16); Chain (4); Compositional bias (1); Disulfide bond (1); Domain (5); Frameshift (1); Glycosylation (2); [NAME] (1); Modified residue (3); Mutagenesis (1); Natural variant (31); Propeptide (1); Region (2); [NAME] conflict (11); Signal peptide (1); Site (3); Topological domain (2); [NAME] (1); Turn (7) | IPR002126; IPR015919; IPR020894; IPR000233; IPR014868 | no_data | [NAME]; apical junction complex; beta-catenin binding; catenin complex; cell adhesion molecule binding; cell-cell adherens junction; cellular response to lithium ion; gamma-catenin binding; homophilic cell adhesion; integral to membrane; lateral plasma membrane; perinuclear region of cytoplasm; positive regulation of transcription factor import into nucleus; transcription activator activity | GO:0015629; GO:0043296; GO:0008013; GO:0016342; GO:0050839; GO:0005913; GO:0071285; GO:0045295; GO:0007156; GO:0016021; GO:0016328; GO:0048471; GO:0042993; GO:0016563 | 9606 | True | True | False | False | 2omzB00 2omvB00 | 98.0952 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -304.864216166 | -302.27961441
2735 | 4.66 | P06703 | S10A6_HUMAN | Protein S100-A6 (S100 calcium-binding protein A6) ([NAME]) (Prolactin receptor-associated protein) (PRA) (Growth factor-inducible protein 2A9) (MLN 4) | S100A6 CACY | Homo sapiens (Human) | 89 | 90 | Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. | S-100 family | no_data | 3D-structure; Acetylation; Calcium; Cell membrane; [NAME] proteome; Cytoplasm; Direct protein sequencing; Membrane; Metal-binding; [NAME]; Polymorphism; Repeat | P04271 | Beta strand (3); [NAME] binding (2); Chain (1); Domain (2); [NAME] (6); Modified residue (1); Natural variant (4); Turn (1) | IPR011992; IPR018247; IPR018249; IPR001751; IPR013787 | no_data | S100 beta binding; axonogenesis; calcium ion binding; calcium-dependent protein binding; cytosol; extrinsic to internal side of plasma membrane; nuclear envelope; perinuclear region of cytoplasm; positive regulation of fibroblast proliferation; protein homodimerization activity; ruffle; signal transduction; tropomyosin binding | GO:0048154; GO:0007409; GO:0005509; GO:0048306; GO:0005829; GO:0031234; GO:0005635; GO:0048471; GO:0048146; GO:0042803; GO:0001726; GO:0007165; GO:0005523 | 9606 | False | False | False | True | 1k9kA00 1k9pA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -297.808817163 | -300.036355579
2048 | 2.21 | P02528 | CRGE_RAT | [NAME] E (Gamma-E-crystallin) ([NAME] 3-1) (Gamma-2) | Cryge | Rattus norvegicus (Rat) | 94 | 174 | no_data | Beta/gamma-crystallin family | no_data | 3D-structure; Eye lens protein; Repeat | no_data | Beta strand (14); Chain (1); Domain (4); [NAME] (4); Initiator methionine (1); Region (1); Turn (4) | IPR001064; IPR011024 | no_data | lens development in camera-type eye; structural constituent of eye lens | GO:0002088; GO:0005212 | 10116 | False | True | False | True | 1zgtA02 1a5dA02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -270.907719155 | -268.543195147
6608 | 2.04 | P0A786 | PYRB_ECOLI | Aspartate carbamoyltransferase catalytic chain (EC 2.1.3.2) (Aspartate transcarbamylase) (ATCase) | pyrB b4245 JW4204 | Escherichia coli (strain K12) | 158 | 311 | no_data | ATCase/OTCase family | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. | 3D-structure; [NAME] proteome; Direct protein sequencing; Pyrimidine biosynthesis; Transferase | no_data | Beta strand (13); Chain (1); [NAME] (16); Initiator methionine (1); [NAME] conflict (12); Turn (6) | IPR006132; IPR006130; IPR006131; IPR002082 | 2.1.3.2 | de novo' pyrimidine base biosynthetic process; amino acid binding; aspartate carbamoyltransferase activity; cellular amino acid metabolic process; cytoplasm; pyrimidine nucleotide biosynthetic process | GO:0006207; GO:0016597; GO:0004070; GO:0006520; GO:0005737; GO:0006221 | 83333 | False | False | False | True | 1f1bA02 1ezzA02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -485.133170306 | -481.149633147
1905 | 2.52 | Q94734 | NP4_RHOPR | Nitrophorin-4 (NP4) | no_data | Rhodnius prolixus (Triatomid bug) | 184 | 205 | Secreted. | Calycin superfamily; [NAME] family | no_data | 3D-structure; Disulfide bond; Heme; Iron; Metal-binding; Secreted; Signal; Vasoactive; Vasodilator | no_data | Beta strand (10); Chain (1); Disulfide bond (2); [NAME] (5); Metal binding (1); Signal peptide (1); Turn (1) | IPR012674; IPR011038; IPR002351 | no_data | extracellular region; metal ion binding; vasodilation | GO:0005576; GO:0046872; GO:0042311 | 13249 | False | False | False | True | 2at0X00 3c76X00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -592.72695868 | -587.987893954
1278 | 17.16 | P01008 | ANT3_HUMAN | [NAME] (ATIII) (Serpin C1) | SERPINC1 AT3 PRO0309 | Homo sapiens (Human) | 140 | 464 | Secreted ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº extracellular space. | Serpin family | no_data | 3D-structure; Blood coagulation; [NAME] proteome; Direct protein sequencing; Disease mutation; Disulfide bond; [NAME]; [NAME]-binding; [NAME]; Polymorphism; [NAME] inhibitor; Secreted; Serine protease inhibitor; Signal; Thrombophilia | P19174 | Beta strand (17); Binding site (3); Chain (1); Disulfide bond (3); Glycosylation (4); [NAME] (14); Mass spectrometry (2); Modified residue (1); Mutagenesis (2); Natural variant (91); [NAME] conflict (8); Signal peptide (1); Site (1); Turn (8) | IPR000215; IPR015555 | no_data | blood coagulation; extracellular space; heparin binding; plasma membrane; protease binding; serine-type endopeptidase inhibitor activity | GO:0007596; GO:0005615; GO:0008201; GO:0005886; GO:0002020; GO:0004867 | 9606 | True | True | True | True | 1jvqL01 2gd4C02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -360.731624875 | -364.435846873
640 | 4.96 | Q92831 | KAT2B_HUMAN | Histone acetyltransferase KAT2B (EC 2.3.1.48) (Lysine acetyltransferase 2B) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (P300/CBP-associated factor) (P/CAF) | [NAME] PCAF | Homo sapiens (Human) | 118 | 832 | Nucleus. | GCN5 family | no_data | 3D-structure; Acetylation; Acyltransferase; Bromodomain; Cell cycle; [NAME] proteome; Host-virus interaction; [NAME]; [NAME]; Polymorphism; Transcription; Transcription regulation; Transferase | Q92793; Q09472; Q86YP4; Q8WXI9; Q16665; P02299; P84040; Q8IXJ6; Q16594; [NAME] | Beta strand (11); Chain (1); Domain (2); [NAME] (12); Modified residue (3); Mutagenesis (4); Natural variant (1); [NAME] conflict (1); Turn (3) | IPR016181; IPR001487; IPR018359; IPR000182; IPR016376; IPR009464 | 2.3.1.48 | N-terminal peptidyl-lysine acetylation; PCAF complex; cell cycle arrest; cellular response to insulin stimulus; chromatin remodeling; chromatin remodeling complex; cyclin-dependent protein kinase inhibitor activity; histone acetylation; histone acetyltransferase activity; histone deacetylase binding; interspecies interaction between organisms; negative regulation of cell proliferation; protein kinase binding; regulation of transcription; DNA-dependent; transcription; transcription coactivator activity | GO:0018076; GO:0000125; GO:0007050; [NAME]; GO:0006338; GO:0016585; GO:0004861; GO:0016573; [NAME]; GO:0042826; GO:0044419; GO:0008285; [NAME]; GO:0006355; GO:0006350; GO:0003713 | 9606 | False | False | False | False | 1jm4B00 1wumA00 | 100 | SOLUTION NMR | SOLUTION NMR | -329.434349077 | -332.588875045
7209 | 3.86 | P42128 | FOXK1_MOUSE | Forkhead box protein [NAME] (Myocyte nuclear factor) (MNF) | [NAME] | Mus musculus (Mouse) | 101 | 719 | Nucleus. | no_data | no_data | 3D-structure; Acetylation; [NAME]; DNA-binding; Developmental protein; Differentiation; Myogenesis; [NAME]; [NAME]; Repressor; Transcription; Transcription regulation | Q62141-2; Q62141-2 | Beta strand (6); Chain (1); Compositional bias (2); DNA binding (1); Domain (1); Erroneous initiation (1); Frameshift (2); [NAME] (4); Initiator methionine (1); Modified residue (19); [NAME] conflict (5) | IPR000253; IPR008984; IPR001766; IPR018122 | no_data | DNA binding; cell differentiation; muscle organ development; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of transcription; DNA-dependent; nucleus; positive regulation of transcription; DNA-dependent; protein binding; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription; transcription activator activity; transcription factor activity; transcription repressor activity | GO:0003677; GO:0030154; GO:0007517; GO:0045786; GO:0030308; GO:0045892; GO:0005634; GO:0045893; GO:0005515; GO:0006357; GO:0043565; GO:0006350; GO:0016563; GO:0003700; GO:0016564 | 10090 | False | False | False | False | 2a3sA00 2d2wA00 | 100 | SOLUTION NMR | SOLUTION NMR | -247.646950126 | -250.359510721
1656 | 11.77 | P47992 | XCL1_HUMAN | Lymphotactin (C motif chemokine 1) (Cytokine SCM-1) (ATAC) (Lymphotaxin) (SCM-1-alpha) (Small-inducible cytokine C1) (XC chemokine ligand 1) | XCL1 LTN SCYC1 | Homo sapiens (Human) | 93 | 114 | Secreted. | Intercrine gamma family | no_data | 3D-structure; [NAME]; [NAME] proteome; Cytokine; Disulfide bond; Secreted; Signal | no_data | Beta strand (4); Chain (1); Disulfide bond (1); [NAME] (3); Signal peptide (1) | IPR001811; IPR008105 | no_data | cell-cell signaling; cellular calcium ion homeostasis; chemokine activity; chemotaxis; extracellular space; immune response; signal transduction | GO:0007267; GO:0006874; GO:0008009; GO:0006935; GO:0005615; GO:0006955; GO:0007165 | 9606 | False | False | False | False | 1j8iA00 1j9oA00 | 100 | SOLUTION NMR | SOLUTION NMR | -193.062015666 | -195.682665256
5894 | 5.86 | O66490 | KAD_AQUAE | Adenylate [NAME] (AK) (EC 2.7.4.3) (ATP-AMP transphosphorylase) | adk aq_078 | Aquifex aeolicus | 203 | 206 | Cytoplasm. | Adenylate [NAME] family | no_data | 3D-structure; ATP-binding; [NAME] proteome; Cytoplasm; [NAME]; Nucleotide-binding; Transferase | no_data | Beta strand (6); Chain (1); [NAME] (9); Nucleotide binding (1); Turn (1) | IPR006259; IPR000850; IPR007862 | 2.7.4.3 | ATP binding; adenylate kinase activity; cytoplasm; nucleotide biosynthetic process | GO:0005524; GO:0004017; GO:0005737; GO:0009165 | 63363 | False | True | False | True | 2rgxA00 2rh5A00 | 99.5074 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -702.714040329 | -696.918734698
5421 | 2.16 | P60906 | SYH_ECOLI | Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS) | hisS b2514 JW2498 | Escherichia coli (strain K12) | 288 | 424 | Cytoplasm. | Class-II aminoacyl-tRNA synthetase family | no_data | 3D-structure; ATP-binding; Aminoacyl-tRNA synthetase; [NAME] proteome; Cytoplasm; Direct protein sequencing; Ligase; Nucleotide-binding; Protein biosynthesis | no_data | Beta strand (16); Chain (1); [NAME] (15); Initiator methionine (1); Turn (2) | IPR002314; IPR006195; IPR004154; IPR015807; IPR004516 | 6.1.1.21 | ATP binding; cytoplasm; histidine-tRNA ligase activity; histidyl-tRNA aminoacylation | GO:0005524; GO:0005737; GO:0004821; GO:0006427 | 83333 | False | False | False | False | 1kmmC01 1kmnC01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -941.028872335 | -932.805729894
4933 | 2.34 | P04964 | DDH_CORGL | Meso-diaminopimelate D-dehydrogenase (Meso-DAP dehydrogenase) (EC 1.4.1.16) | ddh Cgl2617 cg2900 | Corynebacterium glutamicum (Brevibacterium flavum) | 138 | 320 | no_data | no_data | Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2;6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1. | 3D-structure; [NAME] proteome; NADP; Oxidoreductase | no_data | Beta strand (15); Chain (1); [NAME] (16); Turn (5) | IPR000846; IPR010190; IPR016040 | 1.4.1.16 | binding; diaminopimelate dehydrogenase activity; dihydrodipicolinate reductase activity; lysine biosynthetic process via diaminopimelate; oxidation reduction | GO:0005488; GO:0047850; GO:0008839; GO:0009089; GO:0055114 | 1718 | False | False | True | False | 1dapA02 2dapA02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -446.598951209 | -442.644688958
6049 | 2.77 | P00829 | ATPB_BOVIN | ATP synthase subunit beta; mitochondrial (EC 3.6.3.14) | ATP5B | [NAME] taurus ([NAME]) | 277 | 528 | Mitochondrion. Mitochondrion inner membrane. | ATPase alpha/beta chains family | no_data | 3D-structure; ATP synthesis; ATP-binding; Acetylation; CF(1); Direct protein sequencing; Hydrogen ion transport; [NAME]; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Transit peptide; Transport | no_data | Beta strand (17); Chain (1); [NAME] (21); Modified residue (5); Natural variant (1); Nucleotide binding (1); [NAME] conflict (15); Transit peptide (1); Turn (4) | IPR003593; IPR005722; IPR018118; IPR000793; IPR004100; IPR020003; IPR000194 | 3.6.3.14 | ATP binding; ATP catabolic process; ATP synthesis coupled proton transport; hydrogen ion transporting ATP synthase activity; rotational mechanism; hydrogen-exporting ATPase activity; phosphorylative mechanism; mitochondrial inner membrane; proton-transporting ATP synthase complex; catalytic core F(1) | GO:0005524; GO:0006200; GO:0015986; GO:0046933; GO:0008553; GO:0005743; GO:0045261 | 9913 | False | False | True | True | 2jdiD02 1e79E02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -901.324791526 | -909.298318503
1961 | 2.2 | [NAME] | SAV_STRAV | Streptavidin | no_data | Streptomyces avidinii | 119 | 183 | Secreted. | Avidin/streptavidin family | no_data | 3D-structure; Biotin; Direct protein sequencing; Secreted; Signal | no_data | Beta strand (10); Binding site (5); Chain (1); Domain (1); [NAME] (2); [NAME] (1); Signal peptide (1) | IPR005469; IPR017889; IPR005468 | no_data | extracellular region | GO:0005576 | 1895 | False | False | False | False | 1n9yD00 1n9mA00 | 98.3471 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -373.563523188 | -376.997604124
204 | 2.57 | P56277 | MTCPA_HUMAN | Protein p8 MTCP-1 (p8MTCP1) (Mature T-cell proliferation-1 type A) (MTCP-1 type A) | MTCP1 C6.1B | Homo sapiens (Human) | 68 | 68 | Mitochondrion. | no_data | no_data | 3D-structure; Alternative splicing; Chromosomal rearrangement; [NAME] proteome; Disulfide bond; Mitochondrion; Proto-oncogene | no_data | Chain (1); Compositional bias (1); Disulfide bond (3); [NAME] (5); Turn (2) | IPR009069 | no_data | cell proliferation; mitochondrion | GO:0008283; GO:0005739 | 9606 | False | False | False | False | 1hp8A00 2hp8A00 | 100 | SOLUTION NMR | SOLUTION NMR | -211.376016353 | -213.375206194
4012 | 2.06 | A2RJT9 | PYRDA_LACLM | Dihydroorotate dehydrogenase A (EC 1.3.3.1) (Dihydroorotate oxidase A) (DHOdehase A) (DHODase A) (DHOD A) | pyrDA llmg_0952 | Lactococcus lactis subsp. [NAME] (strain MG1363) | 267 | 311 | Cytoplasm. | Dihydroorotate dehydrogenase family; Type 1 subfamily | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (O2 route): step 1/1. | Complete proteome; Cytoplasm; FMN; [NAME]; Oxidoreductase; Pyrimidine biosynthesis | no_data | Active site (1); Chain (1) | IPR013785; IPR012135; IPR005720; IPR001295 | 1.3.3.1 | de novo' pyrimidine base biosynthetic process; UMP biosynthetic process; cytoplasm; dihydroorotate oxidase activity; oxidation reduction | GO:0006207; GO:0006222; GO:0005737; GO:0004158; GO:0055114 | 416870 | False | False | False | False | 1jubA01 1ovdA01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -916.222266607 | -908.120045337
4887 | 3.02 | P00778 | [NAME] | Alpha-lytic protease (EC 3.4.21.12) (Alpha-lytic endopeptidase) | alpha-LP | Lysobacter enzymogenes | 79 | 397 | no_data | [NAME] family | no_data | 3D-structure; Direct protein sequencing; Disulfide bond; [NAME]; [NAME]; Serine protease; Signal; Zymogen | no_data | Active site (3); Beta strand (24); Chain (1); Disulfide bond (3); [NAME] (10); Propeptide (1); [NAME] conflict (1); Signal peptide (1); Turn (3) | IPR004236; IPR001316; IPR018114; [NAME]; IPR009003 | 3.4.21.12 | proteolysis; serine-type endopeptidase activity | GO:0006508; GO:0004252 | 69 | True | True | True | True | 4proC01 2proB01 | 98.7342 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -230.709444004 | -233.120716124
833 | 2.98 | Q14974 | IMB1_HUMAN | Importin subunit beta-1 (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) (Importin-90) | [NAME] | Homo sapiens (Human) | 871 | 876 | Cytoplasm. Nucleus envelope. | Importin beta family | no_data | 3D-structure; Acetylation; [NAME] proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Isopeptide bond; [NAME]; [NAME]; Protein transport; Repeat; Transport; [NAME] conjugation | Q16637-3; O75940 | Beta strand (4); Chain (1); Compositional bias (1); Cross-link (2); Domain (1); [NAME] (53); Modified residue (5); Mutagenesis (2); Region (2); Repeat (8); Sequence conflict (3); Turn (8) | IPR011989; IPR016024; IPR000225; IPR000357; IPR021133; IPR001494 | no_data | NLS-bearing substrate import into nucleus; cytosol; interspecies interaction between organisms; nuclear localization sequence binding; nuclear pore; nucleoplasm; protein domain specific binding; protein import into nucleus; translocation; zinc ion binding | GO:0006607; GO:0005829; GO:0044419; GO:0008139; GO:0005643; GO:0005654; GO:0019904; GO:0000060; GO:0008270 | 9606 | False | False | False | True | 1qgrA00 1qgkA00 | 99.5434 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -2928.86268602 | -2955.65286819
756 | 2.63 | P01563 | IFNA2_HUMAN | Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A) | IFNA2 | Homo sapiens (Human) | 165 | 188 | Secreted. | Alpha/beta interferon family | no_data | 3D-structure; Antiviral defense; [NAME] proteome; Cytokine; Direct protein sequencing; Disulfide bond; [NAME]; Pharmaceutical; Polymorphism; Secreted; Signal | no_data | Beta strand (2); Chain (1); Disulfide bond (2); Glycosylation (1); [NAME] (7); Natural variant (4); Signal peptide (1); Turn (2) | IPR009079; IPR000471; IPR015589 | no_data | cell surface receptor linked signaling pathway; cell-cell signaling; cytokine activity; extracellular space; induction of apoptosis; inflammatory response; interferon-alpha/beta receptor binding; response to virus | GO:0007166; GO:0007267; GO:0005125; GO:0005615; GO:0006917; GO:0006954; GO:0005132; GO:0009615 | 9606 | False | False | False | True | 1itfA00 2hymB00 | 100 | SOLUTION NMR | SOLUTION NMR | -508.961918069 | -514.041656431
5911 | 2.01 | P63320 | RALA_SAGOE | Ras-related protein Ral-A | RALA RAL | Saguinus oedipus (Cotton-top tamarin) | 165 | 206 | Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. | Small GTPase superfamily; [NAME] family | no_data | 3D-structure; Cell cycle; Cell division; Cell membrane; Exocytosis; GTP-binding; [NAME]; Membrane; Methylation; Nucleotide-binding; Prenylation | no_data | Beta strand (6); Chain (1); [NAME] (6); Lipidation (1); Modified residue (1); [NAME] (1); Nucleotide binding (2); Propeptide (1); Turn (1) | IPR003577; [NAME]; IPR001806; IPR015591; IPR020849; IPR005225 | no_data | Edg-2 lysophosphatidic acid receptor binding; GTP binding; GTPase activity; cleavage furrow; cytokinesis; intracellular; membrane raft localization; plasma membrane; regulation of exocytosis; small GTPase mediated signal transduction | GO:0031755; GO:0005525; GO:0003924; GO:0032154; GO:0000910; GO:0005622; GO:0051665; GO:0005886; GO:0017157; GO:0007264 | 9490 | False | False | False | False | 1u8zA00 1u8yB00 | 98.2143 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -542.01401715 | -536.904600131
4438 | 2.05 | P17678 | GATA1_CHICK | Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (NF-E1 DNA-binding protein) (NF-E1a) | GATA1 ERYF1 | Gallus gallus (Chicken) | 66 | 304 | Nucleus. | no_data | no_data | 3D-structure; [NAME]; DNA-binding; Metal-binding; [NAME]; Transcription; Transcription regulation; Zinc; Zinc-finger | no_data | Beta strand (2); Chain (1); [NAME] (2); Turn (2); Zinc finger (2) | IPR000679; IPR013088 | no_data | nucleus; regulation of transcription; DNA-dependent; sequence-specific DNA binding; transcription; transcription factor activity; zinc ion binding | GO:0005634; GO:0006355; GO:0043565; GO:0006350; GO:0003700; GO:0008270 | 9031 | False | False | False | False | 2gatA00 3gatA00 | 100 | SOLUTION NMR | SOLUTION NMR | -128.585463263 | -130.669839472
534 | 3.18 | P0ABE7 | 0 | redesigned apocytochrome B562 (Rd-apocyt b562) | 0 | de novo protein / synthetic construct | 105 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | False | False | False | False | 1yyjA00 1yyxA00 | 100 | SOLUTION NMR | SOLUTION NMR | -341.456658933 | -344.843234099
1329 | 2.07 | Q46604 | FMNB_DESVM | FMN-binding protein | DvMF_2023 | Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637) | 122 | 122 | Cytoplasm. | no_data | no_data | 3D-structure; [NAME] proteome; Cytoplasm; Direct protein sequencing; Electron transport; FMN; [NAME]; Transport | no_data | Beta strand (7); Chain (1); [NAME] (4); [NAME] conflict (1); Turn (2) | IPR011576; IPR009002; IPR012349 | no_data | FMN binding; cytoplasm; electron transport chain; transport | GO:0010181; GO:0005737; GO:0022900; GO:0006810 | 883 | False | False | False | True | 1flmA00 1axjA00 | 100 | X-RAY DIFFRACTION | SOLUTION NMR | -384.009011508 | -380.070814587
1198 | 3.03 | P23727 | P85A_BOVIN | Phosphatidylinositol 3-kinase regulatory subunit alpha (PtdIns-3-kinase regulatory subunit alpha) (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 [NAME] regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) (PI3-kinase subunit p85-alpha) | PIK3R1 | [NAME] taurus ([NAME]) | 86 | 724 | no_data | PI3K p85 subunit family | no_data | 3D-structure; Acetylation; [NAME]; Repeat; SH2 domain; SH3 domain; [NAME] conjugation | P14753; Q9ES52-1; Q9ES52-3; Q07666; P05622; [NAME]; [NAME]; P20339 | Beta strand (13); Chain (1); Domain (4); [NAME] (8); Modified residue (10); Turn (7) | IPR001720; IPR008936; IPR000198; IPR000980; IPR011511; IPR001452 | no_data | 1-phosphatidylinositol-4-phosphate 3-kinase; class IA complex; ErbB-3 class receptor binding; insulin receptor binding; insulin receptor signaling pathway; insulin receptor substrate binding; insulin-like growth factor receptor binding; insulin-like growth factor receptor signaling pathway; phosphoinositide 3-kinase regulator activity; phosphoinositide phosphorylation; positive regulation of establishment of protein localization in plasma membrane; positive regulation of glucose import; signal transduction | GO:0005943; GO:0043125; GO:0005158; GO:0008286; GO:0043560; GO:0005159; GO:0048009; GO:0035014; GO:0046854; GO:0090004; GO:0046326; GO:0007165 | 9913 | False | False | False | False | 1pnjA00 2pniA00 | 100 | SOLUTION NMR | SOLUTION NMR | -224.256200604 | -221.460646764
4635 | 2.92 | P09012 | SNRPA_HUMAN | U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A) | SNRPA | Homo sapiens (Human) | 101 | 282 | Nucleus. | RRM U1 A/B'' family | no_data | 3D-structure; Acetylation; [NAME] proteome; Direct protein sequencing; [NAME]; [NAME]; RNA-binding; Repeat; Ribonucleoprotein; [NAME]; mRNA processing; mRNA splicing | P31939; Q15287; P23246 | Beta strand (7); Chain (1); Compositional bias (1); Domain (2); [NAME] (7); Initiator methionine (1); Modified residue (3); Mutagenesis (5); Turn (2) | IPR012677; IPR000504 | no_data | RNA binding; nuclear mRNA splicing; via spliceosome; nucleotide binding; protein binding; spliceosomal complex | GO:0003723; GO:0000398; GO:0000166; GO:0005515; GO:0005681 | 9606 | False | False | False | False | 1dz5A00 1numA00 | 100 | SOLUTION NMR | NMR, 25 STRUCTURES | -261.705910432 | -265.09086748
395 | 8.53 | P69541 | CAPSD_BPM13 | Capsid protein G8P (Gene 8 protein) (G8P) (Coat protein B) (Major coat protein) | VIII | Enterobacteria phage [NAME] (Bacteriophage M13) | 50 | 73 | Virion. Host membrane; Single-pass type I membrane protein. | Inovirus capsid protein family | no_data | 3D-structure; Capsid protein; Host membrane; [NAME]; Signal; [NAME]; Virion | no_data | Chain (1); [NAME] (3); Signal peptide (1); Topological domain (2); [NAME] (1); Turn (1) | [NAME] | no_data | host cell membrane; integral to membrane; viral capsid | GO:0033644; GO:0016021; GO:0019028 | 10870 | False | False | False | False | 2cpbA00 2cpsA00 | 100 | SOLUTION NMR | SOLUTION NMR | -144.564538638 | -146.288655656
112 | 3.94 | P54725 | [NAME] | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | RAD23A | Homo sapiens (Human) | 45 | 363 | Nucleus. | [NAME] family | no_data | 3D-structure; [NAME] proteome; DNA damage; DNA repair; Host-virus interaction; Isopeptide bond; [NAME]; [NAME]; Polymorphism; Repeat; [NAME] conjugation | Q13501 | Beta strand (11); Chain (1); Cross-link (1); Domain (3); [NAME] (11); Modified residue (6); Natural variant (3); Region (1); Turn (7) | IPR004806; IPR014761; IPR006636; IPR009060; IPR000449; IPR015940; IPR000626; IPR019955; IPR015360 | no_data | damaged DNA binding; interspecies interaction between organisms; nucleotide-excision repair; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein binding; single-stranded DNA binding | GO:0003684; GO:0044419; GO:0006289; GO:0005634; GO:0043161; GO:0005515; GO:0003697 | 9606 | False | False | False | False | 1dv0A00 1ubaA00 | 100 | SOLUTION NMR | NMR, 10 STRUCTURES | -121.360161905 | -119.795215713
5879 | 5.07 | P27144 | KAD4_HUMAN | Adenylate kinase isoenzyme 4; mitochondrial (EC 2.7.4.3) (Adenylate kinase 3-like) (ATP-AMP transphosphorylase) | AK3L1 AK3 AK4; AK3L2 | Homo sapiens (Human) | 220 | 223 | Mitochondrion matrix. | Adenylate [NAME] family | no_data | 3D-structure; ATP-binding; [NAME] proteome; GTP-binding; [NAME]; Mitochondrion; Nucleotide-binding; Transferase | no_data | Beta strand (7); Binding site (1); Chain (1); [NAME] (11); Nucleotide binding (2); [NAME] conflict (3); Turn (4) | IPR006259; IPR000850; IPR007862 | 2.7.4.3 | ATP binding; GTP binding; adenylate kinase activity; mitochondrial matrix; nucleobase; nucleoside; nucleotide and nucleic acid metabolic process | GO:0005524; GO:0005525; GO:0004017; GO:0005759; GO:0006139 | 9606 | False | True | False | False | 2bbwA00 2ar7A00 | 99.5475 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -710.922232797 | -718.630565225
2680 | 3.82 | P0ABH7 | CISY_ECOLI | Citrate synthase (EC 2.3.3.1) | gltA gluT icdB b0720 JW0710 | Escherichia coli (strain K12) | 109 | 427 | no_data | Citrate synthase family | Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2. | 3D-structure; Acetylation; Allosteric enzyme; [NAME] proteome; Direct protein sequencing; Transferase; Tricarboxylic acid cycle | no_data | Active site (2); Beta strand (8); Chain (1); [NAME] (19); Modified residue (1); Mutagenesis (2); [NAME] conflict (3); Turn (7) | IPR016142; IPR002020; IPR016141; IPR019810; IPR010953 | 2.3.3.1 | cellular carbohydrate metabolic process; citrate (Si)-synthase activity; cytosol; membrane; tricarboxylic acid cycle | GO:0044262; GO:0004108; GO:0005829; GO:0016020; GO:0006099 | 83333 | True | False | False | False | 1owcA03 1nxgA03 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -322.371779876 | -318.546769831
5119 | 5.22 | P16113 | PYP_HALHA | Photoactive yellow protein (PYP) | pyp | [NAME] ([NAME]) | 125 | 125 | no_data | [NAME] family | no_data | 3D-structure; Chromophore; Direct protein sequencing; Photoreceptor protein; Receptor; Sensory transduction | no_data | Beta strand (6); Chain (1); Domain (1); [NAME] (7); Modified residue (1); [NAME] conflict (1); Turn (1) | IPR000014; IPR013767; IPR012130 | no_data | photoreceptor activity; phototransduction; protein-chromophore linkage; regulation of transcription; DNA-dependent | GO:0009881; GO:0007602; GO:0018298; GO:0006355 | 1053 | False | True | False | True | 1nwzA00 3pypA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -405.557844907 | -409.987183968
6509 | 2.03 | P0AE22 | APHA_ECOLI | Class B acid phosphatase (EC 3.1.3.2) | aphA napA yjbP b4055 JW4015 | Escherichia coli (strain K12) | 211 | 237 | Periplasm. | Class B bacterial acid phosphatase family | no_data | 3D-structure; [NAME] proteome; Direct protein sequencing; Hydrolase; Magnesium; Metal-binding; Periplasm; Signal | P76349 | Beta strand (8); Chain (1); [NAME] (10); Metal binding (3); Signal peptide (1); Turn (5) | IPR005519; IPR010025 | 3.1.3.2 | acid phosphatase activity; metal ion binding; outer membrane-bounded periplasmic space; protein binding | GO:0003993; GO:0046872; GO:0030288; GO:0005515 | 83333 | False | False | False | False | 1rmtC00 1n9kA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -676.773695448 | -669.29107248
5212 | 2.19 | P01008 | ANT3_HUMAN | [NAME] (ATIII) (Serpin C1) | SERPINC1 AT3 PRO0309 | Homo sapiens (Human) | 260 | 464 | Secreted ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº extracellular space. | Serpin family | no_data | 3D-structure; Blood coagulation; [NAME] proteome; Direct protein sequencing; Disease mutation; Disulfide bond; [NAME]; [NAME]-binding; [NAME]; Polymorphism; [NAME] inhibitor; Secreted; Serine protease inhibitor; Signal; Thrombophilia | P19174 | Beta strand (17); Binding site (3); Chain (1); Disulfide bond (3); Glycosylation (4); [NAME] (14); Mass spectrometry (2); Modified residue (1); Mutagenesis (2); Natural variant (91); [NAME] conflict (8); Signal peptide (1); Site (1); Turn (8) | IPR000215; IPR015555 | no_data | blood coagulation; extracellular space; heparin binding; plasma membrane; protease binding; serine-type endopeptidase inhibitor activity | GO:0007596; GO:0005615; GO:0008201; GO:0005886; GO:0002020; GO:0004867 | 9606 | False | False | False | False | 1dzhI02 1dzgI02 | 98.4848 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -803.691412017 | -794.423095399
1594 | 2.75 | Q969G6 | RIFK_HUMAN | [NAME] kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase) | RFK | Homo sapiens (Human) | 147 | 155 | Cytoplasm. | no_data | Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1. | 3D-structure; ATP-binding; [NAME] proteome; Cytoplasm; FMN; [NAME]; Magnesium; Metal-binding; Nucleotide-binding; Transferase; Zinc | no_data | Active site (1); Beta strand (7); Binding site (10); Chain (1); Erroneous initiation (2); [NAME] (6); Metal binding (1); [NAME] conflict (1) | IPR015865 | 2.7.1.26 | ATP binding; cytosol; metal ion binding; riboflavin biosynthetic process; riboflavin kinase activity | GO:0005524; GO:0005829; GO:0046872; GO:0009231; [NAME] | 9606 | False | False | False | True | 1nb0A00 1q9sA00 | 98.6577 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -463.880483072 | -458.59023537
6144 | 2.75 | Q12650 | MET3_PENCH | Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase) | met3 APS | Penicillium chrysogenum (Penicillium notatum) | 200 | 572 | Cytoplasm. | Sulfate adenylyltransferase family; APS kinase family | Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3. | 3D-structure; ATP-binding; Allosteric enzyme; Amino-acid biosynthesis; [NAME] biosynthesis; Cytoplasm; Direct protein sequencing; [NAME] biosynthesis; Nucleotide-binding; Nucleotidyltransferase; Transferase | no_data | Active site (3); Beta strand (19); Binding site (7); Chain (1); [NAME] (25); Nucleotide binding (3); Region (3); Site (3); Turn (9) | IPR002891; IPR015947; IPR014729; IPR002650 | 2.7.7.4 | ATP binding; cysteine biosynthetic process; cytoplasm; kinase activity; methionine biosynthetic process; sulfate adenylyltransferase (ATP) activity; sulfate assimilation | GO:0005524; GO:0019344; GO:0005737; GO:0016301; GO:0009086; GO:0004781; GO:0000103 | 5076 | False | False | False | False | 1m8pA01 1i2dA01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -596.115308577 | -588.883364587
3521 | 2.19 | P02586 | TNNC2_RABIT | Troponin C; skeletal muscle | TNNC2 | Oryctolagus cuniculus (Rabbit) | 156 | 160 | no_data | Troponin C family | no_data | 3D-structure; Acetylation; Calcium; Direct protein sequencing; [NAME] protein; Repeat | P02643 | Beta strand (6); [NAME] binding (4); Chain (1); Domain (4); [NAME] (9); Initiator methionine (1); Modified residue (1); [NAME] conflict (1) | IPR018248; IPR011992; IPR018247; IPR018249; IPR002048 | no_data | calcium ion binding; troponin T binding | GO:0005509; GO:0031014 | 9986 | False | False | False | True | 1tcfA00 2tn4A00 | 98.0892 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -525.671874328 | -531.442951925
7364 | 3.17 | P02679 | [NAME] | Fibrinogen gamma chain | FGG PRO2061 | Homo sapiens (Human) | 154 | 453 | Secreted. | no_data | no_data | 3D-structure; Alternative splicing; Blood coagulation; Calcium; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; [NAME]; Isopeptide bond; Polymorphism; Secreted; Signal; Sulfation | no_data | Alternative sequence (1); Beta strand (16); [NAME] binding (1); Chain (1); Cross-link (2); Disulfide bond (8); Domain (1); Glycosylation (2); [NAME] (9); Modified residue (2); Natural variant (19); Region (2); [NAME] conflict (4); Signal peptide (1); Turn (4) | IPR002181; IPR014716; IPR014715; IPR012290; IPR020837 | no_data | eukaryotic cell surface binding; external side of plasma membrane; fibrinogen complex; platelet activation; platelet alpha granule lumen; protein binding; bridging; protein polymerization; receptor binding; response to calcium ion; signal transduction | GO:0043499; [NAME]; GO:0005577; GO:0030168; GO:0031093; GO:0030674; GO:0051258; GO:0005102; GO:0051592; GO:0007165 | 9606 | True | False | True | True | 1fidA01 1ficA01 | 98.7952 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -516.58745879 | -522.354083821
446 | 3.29 | [NAME] | SPA_STAAU | [NAME] protein A (IgG-binding protein A) (Staphylococcal protein A) | spa | Staphylococcus aureus | 56 | 508 | Secreted ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº cell wall; Peptidoglycan-anchor. | no_data | no_data | 3D-structure; Cell wall; Direct protein sequencing; IgG-binding protein; Peptidoglycan-anchor; Repeat; Secreted; Signal | no_data | Chain (1); [NAME] (7); Modified residue (1); [NAME] (1); Propeptide (1); Region (1); Repeat (18); [NAME] conflict (1); Signal peptide (1) | IPR005877; IPR019948; IPR009063; IPR019931; IPR005038; IPR018392; IPR002482; IPR003132; IPR001899 | no_data | IgG binding; cell surface; cell wall; cell wall macromolecule catabolic process; extracellular region; membrane; pathogenesis | GO:0019864; GO:0009986; GO:0005618; GO:0016998; GO:0005576; GO:0016020; [NAME] | 1280 | False | False | False | False | 1edkA00 1edlA00 | 100 | SOLUTION NMR | SOLUTION NMR | -176.473383812 | -174.374094714
1952 | 2.04 | P51161 | FABP6_HUMAN | Gastrotropin (GT) (Fatty acid-binding protein 6) (Ileal lipid-binding protein) (ILBP) (Intestinal 15 kDa protein) (I-15P) (Intestinal bile acid-binding protein) (I-BABP) | FABP6 ILBP ILLBP | Homo sapiens (Human) | 127 | 128 | Cytoplasm. | Calycin superfamily; Fatty-acid binding protein (FABP) family | no_data | 3D-structure; Acetylation; Alternative promoter usage; [NAME] proteome; Cytoplasm; Lipid-binding; Polymorphism; Transport | no_data | Alternative sequence (1); Beta strand (11); Chain (1); Erroneous initiation (1); [NAME] (2); Initiator methionine (1); Modified residue (1); Natural variant (3); Turn (1) | IPR011038; IPR000463 | no_data | negative regulation of cell proliferation; transport; transporter activity | GO:0008285; GO:0006810; GO:0005215 | 9606 | False | False | False | False | 1o1uA00 1o1vA00 | 100 | SOLUTION NMR | SOLUTION NMR | -386.176645457 | -390.942703128
5701 | 2.36 | P68688 | GLRX1_ECOLI | Glutaredoxin-1 (Grx1) | [NAME] b0849 JW0833 | Escherichia coli (strain K12) | 85 | 85 | no_data | Glutaredoxin family | no_data | 3D-structure; [NAME] proteome; Deoxyribonucleotide synthesis; Direct protein sequencing; Disulfide bond; Electron transport; Redox-active center; Transport | P73728 | Beta strand (4); Chain (1); Disulfide bond (1); Domain (1); [NAME] (4) | IPR011767; IPR002109; IPR014025; IPR011902; IPR012336; IPR012335 | no_data | cell redox homeostasis; deoxyribonucleotide biosynthetic process; electron carrier activity; electron transport chain; protein binding; protein disulfide oxidoreductase activity; transport | GO:0045454; GO:0009263; GO:0009055; GO:0022900; GO:0005515; GO:0015035; GO:0006810 | 83333 | False | False | False | False | 1grxA00 1qfnA00 | 100 | SOLUTION NMR | SOLUTION NMR | -271.355745733 | -268.136366887
2550 | 2.75 | P04214 | TVB6_MOUSE | T-cell receptor beta chain V region E1 | no_data | Mus musculus (Mouse) | 117 | 136 | no_data | no_data | no_data | 3D-structure; Disulfide bond; Immunoglobulin domain; Receptor; Signal | no_data | Beta strand (10); Chain (1); Disulfide bond (1); Non-terminal residue (1); Region (3); Signal peptide (1) | IPR007110; IPR013783; IPR003599; IPR013106 | no_data | receptor activity | GO:0004872 | 10090 | False | True | True | True | 1kb5B00 1kj2B00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -337.442978271 | -341.8841398
114 | 2.16 | [NAME] | CP119_SULAC | Cytochrome P450 119 (EC 1.14.-.-) (Peroxidase) (EC 1.11.1.7) | cyp119 Saci_2081 | Sulfolobus acidocaldarius | 366 | 368 | Cytoplasm. | Cytochrome P450 family | no_data | 3D-structure; [NAME] proteome; Cytoplasm; Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Peroxidase | no_data | Beta strand (10); Binding site (5); Chain (1); [NAME] (22); Metal binding (1); Mutagenesis (8); Turn (6) | IPR001128; IPR002397; IPR017973; IPR017972 | 1.14.-.-; 1.11.1.7 | cytoplasm; electron carrier activity; heme binding; monooxygenase activity; oxidation reduction; peroxidase activity | GO:0005737; GO:0009055; GO:0020037; GO:0004497; GO:0055114; GO:0004601 | 2285 | False | False | False | True | 1io9A00 1f4uA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1236.87118542 | -1222.81408862
4652 | 3.64 | P26599 | PTBP1_HUMAN | Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) (57 kDa RNA-binding protein PPTB-1) | PTBP1 PTB | Homo sapiens (Human) | 108 | 531 | Nucleus. | no_data | no_data | 3D-structure; Acetylation; Alternative splicing; [NAME] proteome; Direct protein sequencing; [NAME]; [NAME]; RNA-binding; Repeat; mRNA processing; mRNA splicing | Q7ZYE9; Q15365; Q96PU8; P23246 | Alternative sequence (1); Beta strand (23); Chain (1); Compositional bias (1); Domain (4); [NAME] (9); Modified residue (5); Turn (3) | IPR012677; IPR006536; IPR000504 | no_data | RNA splicing; heterogeneous nuclear ribonucleoprotein complex; mRNA processing; nucleolus; nucleoplasm; nucleotide binding; poly-pyrimidine tract binding; protein binding | GO:0008380; GO:0030530; GO:0006397; GO:0005730; GO:0005654; GO:0000166; GO:0008187; GO:0005515 | 9606 | False | False | False | True | 1sjrA00 2adbA01 | 100 | SOLUTION NMR | SOLUTION NMR | -299.978232244 | -304.15178819
7046 | 3.48 | P23639 | PSA2_YEAST | Proteasome component Y7 (EC 3.4.25.1) (Macropain subunit Y7) (Proteinase YSCE subunit 7) (Multicatalytic endopeptidase complex subunit Y7) | PRE8 PRS4 YML092C | Saccharomyces cerevisiae ([NAME]'s yeast) | 250 | 250 | Cytoplasm. Nucleus. | Peptidase T1A family | no_data | 3D-structure; [NAME] proteome; Cytoplasm; Direct protein sequencing; [NAME]; [NAME]; [NAME]; [NAME]; Proteasome; Threonine protease | P32288; P21242; [NAME]; P21243; Q06708 | Beta strand (11); Chain (1); [NAME] (9); Modified residue (2); Turn (3) | IPR000426; IPR001353 | 3.4.25.1 | nucleus; proteasome core complex; alpha-subunit complex; proteasome storage granule; protein binding; threonine-type endopeptidase activity; ubiquitin-dependent protein catabolic process | GO:0005634; GO:0019773; GO:0034515; GO:0005515; GO:0004298; GO:0006511 | 4932 | True | True | True | True | 1jd2A00 1z7qB00 | 99.6 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -795.099519637 | -785.264166049
5117 | 2.13 | P0A7D4 | PURA_ECOLI | Adenylosuccinate synthetase (EC 6.3.4.4) (IMP--aspartate ligase) (AdSS) (AMPSase) | purA adeK b4177 JW4135 | Escherichia coli (strain K12) | 100 | 432 | Cytoplasm. | Adenylosuccinate synthetase family | Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. | 3D-structure; [NAME] proteome; Cytoplasm; Direct protein sequencing; GTP-binding; Ligase; Magnesium; Metal-binding; Nucleotide-binding; Purine biosynthesis | P38104 | Active site (2); Beta strand (17); Chain (1); [NAME] (21); Initiator methionine (1); Metal binding (2); Mutagenesis (7); Nucleotide binding (1); [NAME] conflict (1); Turn (4) | IPR018220; IPR001114 | 6.3.4.4 | GTP binding; adenosine biosynthetic process; adenylosuccinate synthase activity; cytoplasm; magnesium ion binding; membrane; nucleobase; nucleoside and nucleotide interconversion; protein binding; purine nucleotide biosynthetic process | GO:0005525; GO:0046086; GO:0004019; GO:0005737; GO:0000287; GO:0016020; GO:0015949; GO:0005515; GO:0006164 | 83333 | True | True | False | True | 1honA02 1adiA02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -313.943746459 | -309.958712515
2980 | 2.15 | P04573 | CAVP_BRALA | Calcium vector protein (CAVP) | no_data | Branchiostoma lanceolatum (Common lancelet) (Amphioxus) | 68 | 162 | Cytoplasm. | no_data | no_data | 3D-structure; Acetylation; Calcium; Cytoplasm; Direct protein sequencing; Methylation; Muscle protein; Repeat | no_data | Beta strand (1); [NAME] binding (2); Chain (1); Domain (4); [NAME] (10); Initiator methionine (1); Modified residue (3); Turn (2) | IPR018248; IPR011992; IPR018247; IPR018249; IPR002048; IPR001125 | no_data | calcium ion binding; cytoplasm | GO:0005509; GO:0005737 | 7740 | False | False | False | False | 1c7vA00 1c7wA00 | 100 | SOLUTION NMR | SOLUTION NMR | -196.17409356 | -193.445331463
366 | 2.15 | Q9RPJ3 | Q9RPJ3_ECOLX | EcoO109IR | ecoO109IR | Escherichia coli | 147 | 272 | no_data | no_data | no_data | no_data | no_data | no_data | IPR012297; IPR012304 | no_data | no_data | no_data | 562 | False | True | True | True | 1wteB01 1wtdA01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -489.399331818 | -483.47686867
2537 | 2.65 | P14778 | IL1R1_HUMAN | Interleukin-1 receptor type 1 (IL-1RT-1) (IL-1RT1) (IL-1R-1) (Interleukin-1 receptor type I) (Interleukin-1 receptor alpha) (IL-1R-alpha) (p80) (CD121 antigen-like family member A) (CD antigen CD121a) | IL1R1 IL1R IL1RA IL1RT1 | Homo sapiens (Human) | 106 | 569 | Membrane; Single-pass type I membrane protein. | Interleukin-1 receptor family | no_data | 3D-structure; [NAME] proteome; Disulfide bond; [NAME]; Immunoglobulin domain; Membrane; [NAME]; Polymorphism; Receptor; Repeat; Signal; [NAME] | P01584; P18510; Q86XR7; Q9Y4K3 | Beta strand (24); Chain (1); Disulfide bond (5); Domain (4); Glycosylation (6); [NAME] (3); Modified residue (1); Natural variant (2); Signal peptide (1); Topological domain (2); [NAME] (1); Turn (2) | IPR007110; IPR013783; IPR003599; IPR015621; IPR004075; IPR004074; IPR004076; IPR000157 | no_data | cell surface receptor linked signaling pathway; innate immune response; integral to plasma membrane; interleukin-1; Type I; activating receptor activity; interleukin-1-mediated signaling pathway; platelet-derived growth factor receptor binding; response to interleukin-1 | [NAME]; GO:0045087; GO:0005887; GO:0004909; GO:0070498; GO:0005161; GO:0070555 | 9606 | False | True | False | True | 1iraY02 1g0yR02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -283.532069079 | -279.231452382
1354 | 3.26 | P35049 | TRYP_FUSOX | [NAME] (EC 3.4.21.4) | no_data | Fusarium oxysporum (Panama disease fungus) | 124 | 248 | Secreted. | [NAME] family | no_data | 3D-structure; Disulfide bond; [NAME]; [NAME]; Secreted; Serine protease; Signal; Zymogen | no_data | Active site (3); Beta strand (14); Chain (1); Disulfide bond (3); Domain (1); [NAME] (4); Propeptide (1); Signal peptide (1); Site (1); Turn (2) | IPR018114; [NAME]; IPR001314; IPR009003 | 3.4.21.4 | extracellular region; proteolysis; serine-type endopeptidase activity | GO:0005576; GO:0006508; GO:0004252 | 5507 | False | True | True | True | 1pq7A01 1pq5A01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -378.598049088 | -373.562618541
6759 | 3.68 | P20261 | LIP1_CANRU | Lipase 1 (EC 3.1.1.3) | LIP1 | Candida rugosa (Yeast) (Candida cylindracea) | 534 | 549 | no_data | Type-B carboxylesterase/lipase family | no_data | 3D-structure; Direct protein sequencing; Disulfide bond; [NAME]; Hydrolase; Lipid degradation; Signal | no_data | Active site (3); Beta strand (17); Chain (1); Disulfide bond (2); Glycosylation (2); [NAME] (27); Natural variant (1); Signal peptide (1); Turn (5) | IPR002018; IPR019826; IPR019819 | 3.1.1.3 | lipid catabolic process; triglyceride lipase activity | GO:0016042; GO:0004806 | 5481 | False | False | False | False | 1trhA00 1lpmA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1837.55316203 | -1815.66756514
7392 | 2.42 | P22259 | PCKA_ECOLI | Phosphoenolpyruvate carboxykinase [ATP] (PEP carboxykinase) (PEPCK) (EC 4.1.1.49) (Phosphoenolpyruvate carboxylase) | pckA pck b3403 JW3366 | Escherichia coli (strain K12) | 251 | 540 | Cytoplasm. | Phosphoenolpyruvate carboxykinase [ATP] family | Carbohydrate biosynthesis; gluconeogenesis. | 3D-structure; ATP-binding; Acetylation; Allosteric enzyme; Calcium; Complete proteome; Cytoplasm; Decarboxylase; Direct protein sequencing; Gluconeogenesis; Lyase; Nucleotide-binding | no_data | Beta strand (30); Chain (1); Frameshift (1); [NAME] (25); Mass spectrometry (1); Modified residue (2); Mutagenesis (2); Nucleotide binding (1); [NAME] conflict (15); Turn (8) | IPR001272; IPR013035; IPR008210; IPR015994 | 4.1.1.49 | ATP binding; cytoplasm; gluconeogenesis; phosphoenolpyruvate carboxykinase (ATP) activity | GO:0005524; GO:0005737; GO:0006094; GO:0004612 | 83333 | False | False | False | False | 1os1A03 1k3dA03 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -833.774737131 | -844.073805961
3312 | 2.37 | P10822 | ICW3_PSOTE | Chymotrypsin inhibitor 3 (WCI-3) | no_data | [NAME] tetragonolobus (Goa bean) (Asparagus bean) | 179 | 207 | no_data | Protease inhibitor [NAME] (leguminous Kunitz-type inhibitor) family | no_data | 3D-structure; Direct protein sequencing; Disulfide bond; [NAME] inhibitor; Serine protease inhibitor; Signal | no_data | Beta strand (14); Chain (1); Disulfide bond (2); [NAME] (2); Signal peptide (1); Site (1) | IPR011065; IPR002160 | no_data | serine-type endopeptidase inhibitor activity | GO:0004867 | 3891 | False | True | False | False | 2wbcA00 1wbcA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -529.772725452 | -522.32163002
6705 | 2.1 | Q05489 | LIP_BURGL | Lipase (EC 3.1.1.3) (Triacylglycerol lipase) | lipA | Burkholderia glumae (Pseudomonas glumae) | 316 | 358 | Secreted. | AB hydrolase superfamily; Pseudomonas lipase family | no_data | 3D-structure; Calcium; Direct protein sequencing; Disulfide bond; Hydrolase; Lipid degradation; Metal-binding; Secreted; Signal | Q05490 | Active site (3); Beta strand (12); Chain (1); Disulfide bond (1); [NAME] (14); Metal binding (4); Mutagenesis (9); [NAME] conflict (1); Signal peptide (1); Turn (2) | IPR000073 | 3.1.1.3 | extracellular region; lipid catabolic process; metal ion binding; protein binding; triglyceride lipase activity | GO:0005576; GO:0016042; GO:0046872; GO:0005515; GO:0004806 | 337 | False | False | True | True | 1cvlA00 1tahA00 | 98.7461 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1103.81125968 | -1090.54641432
5470 | 3.22 | Q5SJH3 | RS16_THET8 | 30S ribosomal protein S16 | [NAME] | [NAME] thermophilus (strain HB8 / ATCC 27634 / DSM 579) | 83 | 88 | no_data | Ribosomal protein S16P family | no_data | 3D-structure; [NAME] proteome; Direct protein sequencing; [NAME]; Ribosomal protein | no_data | Beta strand (4); Chain (1); [NAME] (2); Mass spectrometry (1) | IPR000307 | no_data | ribosome; structural constituent of ribosome; translation | GO:0005840; GO:0003735; GO:0006412 | 300852 | False | True | True | True | 1i94P00 1emwA00 | 100 | X-RAY DIFFRACTION | SOLUTION NMR | -236.435024538 | -239.935250439
6018 | 2.16 | P35288 | RAB23_MOUSE | Ras-related protein Rab-23 (Rab-15) | Rab23 | Mus musculus (Mouse) | 164 | 237 | Cell membrane; Lipid-anchor; Cytoplasmic side. | Small GTPase superfamily; Rab family | no_data | 3D-structure; Cell membrane; GTP-binding; [NAME]; Membrane; Methylation; Nucleotide-binding; Prenylation; Protein transport; Transport | no_data | Beta strand (7); Chain (1); [NAME] (7); Lipidation (1); Modified residue (1); [NAME] (1); Nucleotide binding (3); Propeptide (1); Turn (1) | [NAME]; IPR015593; IPR013753; IPR001806; IPR005225; IPR020851 | no_data | GTP binding; embryonic digit morphogenesis; negative regulation of proteolysis; plasma membrane; protein transport; regulation of smoothened signaling pathway; small GTPase mediated signal transduction; spinal cord dorsal/ventral patterning | GO:0005525; GO:0042733; GO:0045861; GO:0005886; GO:0015031; GO:0008589; GO:0007264; GO:0021513 | 10090 | False | False | False | True | 1z2aA00 1z22A00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -510.225109306 | -517.227201911
4506 | 2.43 | P00198 | FER_CLOAC | Ferredoxin | no_data | Clostridium acidi-urici | 55 | 55 | no_data | no_data | no_data | 3D-structure; 4Fe-4S; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Repeat; Transport | no_data | Beta strand (3); Chain (1); Domain (2); [NAME] (2); Metal binding (8); Turn (1) | IPR001450; IPR017896; IPR017900; IPR000813 | no_data | 4 iron; 4 sulfur cluster binding; electron carrier activity; electron transport chain; metal ion binding; transport | GO:0051539; GO:0009055; GO:0022900; GO:0046872; GO:0006810 | 1556 | False | False | False | False | 2fdnA00 1fdnA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -122.475473004 | -124.83952891
2372 | 3.57 | P84751 | HVM63_MOUSE | Ig heavy chain Mem5. | 0 | Mus musculus (house mouse) | 119 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | False | True | False | False | 2gfbB01 1knoB01 | 99.1667 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -363.752224206 | -358.616925575
2219 | 2.24 | P04213 | TVB5_MOUSE | T-cell receptor beta chain V region C5 (Fragment) | no_data | Mus musculus (Mouse) | 112 | 122 | no_data | no_data | no_data | 3D-structure; Disulfide bond; Immunoglobulin domain; Receptor; Signal | no_data | Beta strand (12); Chain (1); Disulfide bond (1); [NAME] (1); Non-terminal residue (2); Region (3); Signal peptide (1); Turn (1) | IPR007110; IPR013783; IPR013106; IPR003596 | no_data | receptor activity | GO:0004872 | 10090 | False | False | False | True | 1d9kB00 1bwmA01 | 99.1071 | X-RAY DIFFRACTION | SOLUTION NMR | -307.400713794 | -302.406984571
1661 | 3.83 | P19821 | DPO1_THEAQ | DNA polymerase I; thermostable (EC 2.7.7.7) (Taq polymerase 1) | polA pol1 | [NAME] aquaticus | 134 | 832 | no_data | DNA polymerase type-A family | no_data | 3D-structure; DNA damage; DNA repair; DNA replication; DNA-binding; DNA-directed DNA polymerase; Direct protein sequencing; Nucleotidyltransferase; Transferase | no_data | Beta strand (25); Chain (1); [NAME] (42); Region (1); [NAME] conflict (1); Turn (13) | IPR020046; IPR020045; IPR002421; IPR020047; IPR019760; IPR001098; IPR018320; IPR002298; IPR008918; IPR003583; IPR012337; IPR015361 | 2.7.7.7 | 5'-3' exonuclease activity; DNA binding; DNA repair; DNA replication; DNA-directed DNA polymerase activity; nucleoside binding | GO:0008409; GO:0003677; GO:0006281; GO:0006260; GO:0003887; GO:0001882 | 271 | True | True | True | True | 1qssA04 1ktqA04 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -471.608588792 | -465.481083237
542 | 2.58 | P02941 | MCP2_SALTY | Methyl-accepting chemotaxis protein II (MCP-II) (Aspartate chemoreceptor protein) | tar cheM STM1919 | Salmonella typhimurium | 157 | 553 | Cell inner membrane; Multi-pass membrane protein. | no_data | no_data | 3D-structure; Cell inner membrane; Cell membrane; [NAME]; [NAME] proteome; Membrane; Methylation; Transducer; [NAME] | no_data | Beta strand (1); Chain (1); Domain (2); [NAME] (6); Modified residue (4); Region (1); [NAME] conflict (2); Topological domain (3); [NAME] (2); Turn (2) | IPR004090; IPR003122; IPR004091; IPR004089; IPR003660 | no_data | chemotaxis; integral to membrane; plasma membrane; signal transduction; transmembrane receptor activity | GO:0006935; GO:0016021; GO:0005886; GO:0007165; GO:0004888 | 90371 | False | False | False | False | 2ligA00 1lihA00 | 98.125 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -549.424984702 | -542.090411896
423 | 10.11 | P0C0Y1 | LHB1_RHOSH | Light-harvesting protein [NAME] beta chain (LH-3A) (Antenna pigment protein beta chain) | pufB | Rhodobacter sphaeroides ([NAME] sphaeroides) | 48 | 49 | Cell inner membrane; Single-pass type II membrane protein. | Antena complex beta subunit family | no_data | 3D-structure; Antenna complex; [NAME]; Cell inner membrane; Cell membrane; [NAME]; Chromophore; Direct protein sequencing; Light-harvesting polypeptide; Magnesium; Membrane; Metal-binding; Signal-anchor; [NAME] | no_data | Chain (1); [NAME] (4); Initiator methionine (1); Metal binding (2); Topological domain (2); [NAME] (1) | IPR000066; IPR002362 | no_data | bacteriochlorophyll binding; electron transporter; transferring electrons within the cyclic electron transport pathway of photosynthesis activity; integral to membrane; metal ion binding; photosynthesis; light reaction; plasma membrane; plasma membrane light-harvesting complex; protein-chromophore linkage | GO:0042314; GO:0045156; GO:0016021; GO:0046872; GO:0019684; GO:0005886; GO:0030077; GO:0018298 | 1063 | False | False | False | False | 1dx7A00 1jo5A00 | 100 | SOLUTION NMR | SOLUTION NMR | -128.085401489 | -130.330700782
2 | 6.33 | P62508 | ERR3_HUMAN | Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (ERR gamma-2) (Nuclear receptor subfamily 3 group B member 3) | ESRRG ERR3 ERRG2 KIAA0832 NR3B3 | Homo sapiens (Human) | 222 | 458 | Nucleus. | Nuclear hormone receptor family; NR3 subfamily | no_data | 3D-structure; Activator; Alternative splicing; [NAME] proteome; DNA-binding; Isopeptide bond; Metal-binding; [NAME]; [NAME]; Polymorphism; Receptor; Transcription; Transcription regulation; [NAME] conjugation; Zinc; Zinc-finger | no_data | Alternative sequence (2); Beta strand (4); Chain (1); Cross-link (1); DNA binding (1); Erroneous initiation (1); [NAME] (11); Modified residue (1); Mutagenesis (8); Natural variant (1); Sequence caution (1); [NAME] conflict (8); Turn (1); Zinc finger (2) | IPR008946; IPR000536; IPR001723; IPR001628; IPR013088 | no_data | AF-2 domain binding; nucleus; positive regulation of transcription; DNA-dependent; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; transcription; transcription activator activity; transcription factor activity; zinc ion binding | GO:0050682; GO:0005634; GO:0045893; GO:0043565; GO:0005496; GO:0003707; GO:0006350; GO:0016563; GO:0003700; GO:0008270 | 9606 | False | True | True | True | 2gpuA00 2gpvA00 | 99.1071 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -734.151748888 | -723.762224292
3104 | 2.08 | P54760 | EPHB4_HUMAN | Ephrin type-B receptor 4 (EC 2.7.10.1) (Tyrosine-protein kinase receptor [NAME]) (Tyrosine-protein kinase TYRO11) | EPHB4 HTK TYRO11 | Homo sapiens (Human) | 185 | 987 | Membrane; Single-pass type I membrane protein. | Protein kinase superfamily; [NAME] protein kinase family; Ephrin receptor subfamily | no_data | 3D-structure; ATP-binding; [NAME] proteome; [NAME]; [NAME]; Membrane; Nucleotide-binding; [NAME]; Polymorphism; Receptor; Repeat; Signal; Transferase; [NAME]; Tyrosine-protein kinase | no_data | Active site (1); Beta strand (26); Binding site (1); Chain (1); Compositional bias (1); Domain (4); Glycosylation (3); [NAME] (21); Modified residue (13); [NAME] (1); Natural variant (9); Nucleotide binding (1); [NAME] conflict (4); Signal peptide (1); Topological domain (2); [NAME] (1); Turn (3) | IPR001090; IPR008957; IPR003961; IPR008979; IPR011009; IPR000719; IPR017441; IPR001660; IPR010993; IPR013761; IPR021129; IPR001245; IPR011641; IPR020635; IPR020685; IPR008266; IPR016257; IPR001426 | 2.7.10.1 | ATP binding; cell proliferation; cell surface; ephrin receptor activity; integral to plasma membrane; organ morphogenesis; protein amino acid phosphorylation; regulation of angiogenesis; transmembrane receptor [NAME] signaling pathway | GO:0005524; GO:0008283; GO:0009986; GO:0005003; GO:0005887; GO:0009887; GO:0006468; GO:0045765; GO:0007169 | 9606 | False | True | False | False | 2bbaA00 2hleA00 | 98.4043 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -573.982004031 | -582.81429994
3718 | 2.06 | Q15819 | UB2V2_HUMAN | Ubiquitin-conjugating enzyme E2 variant 2 (MMS2 homolog) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) ([NAME] protein) (DDVit 1) | UBE2V2 MMS2 UEV2 | Homo sapiens (Human) | 140 | 145 | no_data | Ubiquitin-conjugating enzyme family | no_data | 3D-structure; Acetylation; [NAME] proteome; Direct protein sequencing; Polymorphism; [NAME] conjugation pathway | Q94A97; P61088 | Beta strand (4); Chain (1); [NAME] (4); Initiator methionine (1); Modified residue (2); Natural variant (3); Turn (4) | IPR016135; IPR000608 | no_data | DNA double-strand break processing; UBC13-MMS2 complex; cell proliferation; cytoplasm; nucleus; protein binding; protein polyubiquitination; regulation of DNA repair; regulation of protein metabolic process; small conjugating protein ligase activity | GO:0000729; GO:0031372; GO:0008283; GO:0005737; GO:0005634; GO:0005515; GO:0000209; GO:0006282; GO:0051246; GO:0019787 | 9606 | True | False | True | True | 1j7dA00 1zguA00 | 99.2857 | X-RAY DIFFRACTION | SOLUTION NMR | -436.633904475 | -429.915326992
1795 | 3.23 | P04587 | POL_HV1B5 | Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); [NAME] peptide p2; Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); [NAME] (EC 3.4.23.16) ([NAME]) (PR); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (p66 [NAME]); p51 RT; p15; [NAME] (IN)] | gag-pol | Human immunodeficiency virus type 1 group M subtype B (isolate BH5) (HIV-1) | 99 | 1447 | Virion. Host nucleus. Host cytoplasm. Host cell membrane; Lipid-anchor.  Virion.  Virion. Host nucleus. Host cytoplasm. | no_data | no_data | 3D-structure; AIDS; Aspartyl protease; Capsid maturation; Capsid protein; DNA integration; DNA recombination; DNA-directed DNA polymerase; Endonuclease; Host cell membrane; Host cytoplasm; Host membrane; Host nucleus; [NAME]; [NAME]; Magnesium; Membrane; Metal-binding; Multifunctional enzyme; Myristate; Nuclease; Nucleotidyltransferase; [NAME]; [NAME]; RNA-binding; RNA-directed DNA polymerase; Repeat; Ribosomal frameshifting; Transferase; Viral nucleoprotein; Virion; Zinc; Zinc-finger | no_data | Active site (1); Beta strand (8); Chain (10); DNA binding (1); Domain (4); [NAME] (5); Initiator methionine (1); Lipidation (1); Metal binding (9); Modified residue (1); [NAME] (3); [NAME] (2); Region (1); Site (12); Turn (1); Zinc finger (3) | IPR000721; IPR001037; [NAME]; [NAME]; IPR003308; IPR000071; IPR018061; [NAME]; IPR021109; IPR001969; IPR009007; IPR012337; IPR008916; IPR008919; IPR010999; IPR000477; IPR002156; IPR010659; IPR010661; IPR013084; IPR001878 | 3.4.23.16; 2.7.7.49; 2.7.7.7; 3.1.26.13 | DNA binding; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; cytosol; host cell cytoplasm; host cell nucleus; host cell plasma membrane; initiation of viral infection; integrase activity; membrane; proteolysis; provirus integration; ribonuclease H activity; structural molecule activity; viral capsid; viral procapsid maturation; zinc ion binding | GO:0003677; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0005829; GO:0030430; GO:0042025; GO:0020002; GO:0019059; GO:0008907; GO:0016020; GO:0006508; GO:0019047; GO:0004523; GO:0005198; GO:0019028; GO:0046797; GO:0008270 | 11682 | True | True | True | True | 2nmzA00 2aogA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -279.639525614 | -274.838663671
1971 | 2.39 | [NAME] | SAV_STRAV | Streptavidin | no_data | Streptomyces avidinii | 118 | 183 | Secreted. | Avidin/streptavidin family | no_data | 3D-structure; Biotin; Direct protein sequencing; Secreted; Signal | no_data | Beta strand (10); Binding site (5); Chain (1); Domain (1); [NAME] (2); [NAME] (1); Signal peptide (1) | IPR005469; IPR017889; IPR005468 | no_data | extracellular region | GO:0005576 | 1895 | False | True | False | False | 1swtA00 1swsB00 | 99.1525 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -367.524254762 | -373.308495784
4439 | 3.88 | P17429 | AREA_EMENI | Nitrogen regulatory protein areA | areA AN8667 | Emericella nidulans (Aspergillus nidulans) | 66 | 876 | Nucleus. | no_data | no_data | 3D-structure; Activator; [NAME] proteome; DNA-binding; Metal-binding; Nitrate assimilation; [NAME]; Transcription; Transcription regulation; Zinc; Zinc-finger | no_data | Beta strand (3); Chain (1); DNA binding (1); [NAME] (2); Turn (2); Zinc finger (1) | IPR011420; IPR013860; IPR000679; IPR013088 | no_data | nitrate assimilation; nucleus; protein binding; regulation of transcription; DNA-dependent; sequence-specific DNA binding; transcription; transcription activator activity; transcription factor activity; zinc ion binding | GO:0042128; GO:0005634; GO:0005515; GO:0006355; GO:0043565; GO:0006350; GO:0016563; GO:0003700; GO:0008270 | 162425 | False | False | False | False | 4gatA00 5gatA00 | 100 | SOLUTION NMR | SOLUTION NMR | -131.443978306 | -134.711795622
4580 | 2.27 | P04585 | POL_HV1H2 | Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); [NAME] peptide p2; Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); [NAME] (EC 3.4.23.16) ([NAME]) (PR); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (p66 [NAME]); p51 RT; p15; [NAME] (IN)] | gag-pol | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) | 75 | 1435 | Virion. Host nucleus. Host cytoplasm. Host cell membrane; Lipid-anchor.  Virion.  Virion. Host nucleus. Host cytoplasm. | no_data | no_data | 3D-structure; AIDS; Aspartyl protease; Capsid maturation; Capsid protein; DNA integration; DNA recombination; DNA-directed DNA polymerase; Endonuclease; Host cell membrane; Host cytoplasm; Host membrane; Host nucleus; Host-virus interaction; [NAME]; [NAME]; Magnesium; Membrane; Metal-binding; Multifunctional enzyme; Myristate; Nuclease; Nucleotidyltransferase; [NAME]; [NAME]; RNA-binding; RNA-directed DNA polymerase; Repeat; Ribosomal frameshifting; Transferase; Viral nucleoprotein; Virion; Zinc; Zinc-finger | no_data | Active site (1); Beta strand (49); Chain (10); DNA binding (1); Domain (4); [NAME] (26); Initiator methionine (1); Lipidation (1); Metal binding (9); Modified residue (1); [NAME] (3); Mutagenesis (43); Natural variant (159); [NAME] (2); Region (2); Site (14); Turn (9); Zinc finger (3) | IPR000721; IPR001037; [NAME]; [NAME]; IPR003308; IPR000071; IPR018061; [NAME]; IPR021109; IPR001969; IPR009007; IPR012337; IPR008916; IPR008919; IPR010999; IPR000477; IPR002156; IPR010659; IPR010661; IPR013084; IPR001878 | 3.4.23.16; 2.7.7.49; 2.7.7.7; 3.1.26.13 | DNA binding; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; cytosol; host cell cytoplasm; host cell nucleus; host cell plasma membrane; initiation of viral infection; integrase activity; interspecies interaction between organisms; membrane; proteolysis; provirus integration; ribonuclease H activity; structural molecule activity; viral capsid; viral procapsid maturation; zinc ion binding | GO:0003677; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0005829; GO:0030430; GO:0042025; GO:0020002; GO:0019059; GO:0008907; GO:0044419; GO:0016020; GO:0006508; GO:0019047; GO:0004523; GO:0005198; GO:0019028; GO:0046797; GO:0008270 | 11706 | False | False | False | False | 1jlfB02 1jlgB02 | 98.6667 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -201.955624543 | -205.673639279
6670 | 2.63 | P0A1F6 | UDP_SALTY | Uridine phosphorylase (UrdPase) (UPase) (EC 2.4.2.3) | udp STM3968 STMD1.21 | Salmonella typhimurium | 251 | 253 | Cytoplasm. | PNP/UDP phosphorylase family | Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. | 3D-structure; [NAME] proteome; Cytoplasm; Glycosyltransferase; Transferase | no_data | Beta strand (10); Chain (1); [NAME] (11); Initiator methionine (1); [NAME] conflict (1); Turn (3) | IPR000845; IPR018017; IPR018016; IPR010058 | 2.4.2.3 | cytoplasm; nucleoside metabolic process; nucleotide catabolic process; uridine phosphorylase activity | GO:0005737; GO:0009116; GO:0009166; GO:0004850 | 90371 | False | True | False | True | 2i8aA00 1y1tA00 | 99.6016 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -854.925350843 | -842.425012165
6987 | 3.8 | P12676 | CHOD_STRS0 | Cholesterol oxidase (CHOD) (EC 1.1.3.6) | choA | Streptomyces sp. (strain SA-COO) | 337 | 546 | Secreted. | GMC oxidoreductase family | Steroid metabolism; cholesterol metabolism. | 3D-structure; Cholesterol metabolism; FAD; [NAME]; Lipid metabolism; Oxidoreductase; Secreted; Signal; Steroid metabolism | no_data | Active site (2); Beta strand (23); Chain (1); [NAME] (19); Mutagenesis (2); Nucleotide binding (1); Signal peptide (1); Turn (4) | IPR000172; IPR007867; [NAME]; IPR017909 | 1.1.3.6 | FAD binding; [NAME] process; cholesterol oxidase activity; extracellular region; oxidation reduction | GO:0050660; GO:0008203; GO:0016995; GO:0005576; GO:0055114 | 74576 | False | False | False | False | 3b3rA01 3b6dA01 | 98.5163 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1140.76548433 | -1123.91605974
1622 | 2.37 | P13123 | DN71_SULAC | DNA-binding protein 7d (7 kDa DNA-binding protein d) (Sac7d) [Cleaved into: DNA-binding protein 7a (7 kDa DNA-binding protein a) (Sac7a); DNA-binding protein 7b (7 kDa DNA-binding protein b) (Sac7b)] | Saci_0064 | Sulfolobus acidocaldarius | 66 | 66 | no_data | 7 kDa DNA-binding/endoribonuclease [NAME] family | no_data | 3D-structure; [NAME] proteome; DNA-binding; Direct protein sequencing; Methylation | no_data | Beta strand (5); Chain (3); [NAME] (3); Initiator methionine (1); Modified residue (2) | IPR016197; IPR003212 | no_data | DNA binding; endoribonuclease activity | GO:0003677; GO:0004521 | 2285 | False | False | True | True | 1azqA00 1sapA00 | 100 | X-RAY DIFFRACTION | SOLUTION NMR | -194.623877048 | -198.033872125
3560 | 2.12 | P00216 | [NAME] | Ferredoxin | fdx fer2 VNG_2293G | Halobacterium salinarium (Halobacterium halobium) | 128 | 129 | no_data | 2Fe2S plant-type ferredoxin family | no_data | 2Fe-2S; 3D-structure; Acetylation; [NAME] proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Transport | no_data | Beta strand (7); Chain (1); Domain (1); [NAME] (6); Initiator methionine (1); Metal binding (4); Modified residue (1); Turn (2) | IPR006058; IPR012675; IPR001041 | no_data | 2 iron; 2 sulfur cluster binding; electron carrier activity; electron transport chain; metal ion binding; transport | GO:0051537; GO:0009055; GO:0022900; GO:0046872; GO:0006810 | 2242 | False | False | False | False | 1e0zA00 1e10A00 | 100 | SOLUTION NMR | SOLUTION NMR | -363.377416801 | -356.46841303
1070 | 2.55 | Q05158 | CSRP2_COTJA | Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) | CSRP2 | Coturnix coturnix japonica (Japanese quail) | 59 | 194 | Nucleus. | no_data | no_data | 3D-structure; Developmental protein; Differentiation; LIM domain; Metal-binding; [NAME]; Repeat; Zinc | no_data | Beta strand (9); Chain (1); Compositional bias (2); Domain (2); [NAME] (2); Initiator methionine (1); [NAME] (1); Turn (2) | [NAME] | no_data | cell differentiation; multicellular organismal development; nucleus; zinc ion binding | GO:0030154; GO:0007275; GO:0005634; GO:0008270 | 93934 | False | False | False | False | 1ibiA00 1qliA00 | 100 | SOLUTION NMR | SOLUTION NMR | -140.840772116 | -144.037738618
2880 | 5.73 | P06787 | CALM_YEAST | [NAME] (CaM) | CMD1 YBR109C YBR0904 | Saccharomyces cerevisiae ([NAME]'s yeast) | 77 | 147 | no_data | [NAME] family | no_data | 3D-structure; Calcium; Complete proteome; Direct protein sequencing; [NAME]; Repeat | P43582; [NAME]; P22696; P33203; P39940; P46995; Q06525 | Beta strand (5); [NAME] binding (3); Chain (1); Domain (4); [NAME] (8); Modified residue (4); Mutagenesis (6) | IPR018248; IPR011992; IPR018247; IPR018249; IPR002048 | no_data | NLS-bearing substrate import into nucleus; calcium ion binding; calcium-dependent protein binding; cell budding; cellular bud neck; cellular bud tip; central plaque of spindle pole body; incipient cellular bud site; karyogamy during conjugation with cellular fusion; mating projection tip; microautophagy; phosphatidylinositol biosynthetic process; receptor-mediated endocytosis; spindle pole body organization; transcription factor import into nucleus; vacuole fusion; non-autophagic | GO:0006607; GO:0005509; GO:0048306; GO:0007114; GO:0005935; GO:0005934; GO:0005823; GO:0000131; GO:0000742; [NAME]; GO:0016237; GO:0006661; GO:0006898; GO:0051300; GO:0042991; GO:0042144 | 4932 | False | False | False | False | 1f54A00 1f55A00 | 100 | SOLUTION NMR | SOLUTION NMR | -221.755667889 | -217.550205795
7372 | 2.84 | P0A6G7 | CLPP_ECOLI | ATP-dependent [NAME] protease proteolytic subunit (EC 3.4.21.92) ([NAME]) (Caseinolytic protease) (Protease Ti) (Heat shock protein F21.5) | clpP lopP b0437 JW0427 | Escherichia coli (strain K12) | 193 | 207 | Cytoplasm. | Peptidase S14 family | no_data | 3D-structure; ATP-binding; [NAME] proteome; Cytoplasm; Direct protein sequencing; [NAME]; Nucleotide-binding; [NAME]; Serine protease; Stress response; [NAME] | no_data | Active site (2); Beta strand (10); Chain (1); [NAME] (7); Propeptide (1); Turn (1) | IPR001907; IPR018215 | 3.4.21.92 | ATP binding; cytosol; membrane; misfolded or incompletely synthesized protein catabolic process; response to heat; serine-type endopeptidase activity | GO:0005524; GO:0005829; GO:0016020; GO:0006515; GO:0009408; GO:0004252 | 83333 | False | True | False | True | 1yg6A00 2fzsB00 | 99.4819 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -622.847589923 | -633.503901869
6623 | 2.58 | P0A786 | PYRB_ECOLI | Aspartate carbamoyltransferase catalytic chain (EC 2.1.3.2) (Aspartate transcarbamylase) (ATCase) | pyrB b4245 JW4204 | Escherichia coli (strain K12) | 152 | 311 | no_data | ATCase/OTCase family | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. | 3D-structure; [NAME] proteome; Direct protein sequencing; Pyrimidine biosynthesis; Transferase | no_data | Beta strand (13); Chain (1); [NAME] (16); Initiator methionine (1); [NAME] conflict (12); Turn (6) | IPR006132; IPR006130; IPR006131; IPR002082 | 2.1.3.2 | de novo' pyrimidine base biosynthetic process; amino acid binding; aspartate carbamoyltransferase activity; cellular amino acid metabolic process; cytoplasm; pyrimidine nucleotide biosynthetic process | GO:0006207; GO:0016597; GO:0004070; GO:0006520; GO:0005737; GO:0006221 | 83333 | True | False | True | True | 2fzgA01 1skuA01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -487.228525335 | -478.686747035
158 | 3.13 | P00004 | CYC_HORSE | Cytochrome c | CYCS CYC | Equus caballus (Horse) | 104 | 105 | Mitochondrion matrix. | Cytochrome c family | no_data | 3D-structure; Acetylation; Direct protein sequencing; Electron transport; Heme; Iron; Metal-binding; Mitochondrion; Respiratory chain; Transport | no_data | Binding site (2); Chain (1); [NAME] (5); Initiator methionine (1); Metal binding (2); Modified residue (1); Turn (1) | IPR002327; IPR009056; IPR003088 | no_data | DNA fragmentation involved in apoptosis; cytosol; electron transport chain; electron transporter; transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; heme binding; mitochondrial matrix; respiratory chain; transport | GO:0006309; GO:0005829; GO:0022900; GO:0045155; GO:0020037; GO:0005759; GO:0070469; GO:0006810 | 9796 | False | False | True | True | 1ocdA00 2frcA00 | 100 | SOLUTION NMR | SOLUTION NMR | -285.668622435 | -291.668380066
1761 | 3.15 | P09547 | SWI1_YEAST | SWI/SNF chromatin-remodeling complex subunit SWI1 (SWI/SNF complex subunit SWI1) (Transcription regulatory protein SWI1) (Transcription regulatory protein ADR6) (Regulatory protein GAM3) | ADR6 GAM3 SWI1 YPL016W LPA1 | Saccharomyces cerevisiae ([NAME]'s yeast) | 102 | 1314 | Nucleus. | SWI1 family | no_data | 3D-structure; Activator; [NAME] proteome; DNA-binding; Metal-binding; [NAME]; [NAME]; Transcription; Transcription regulation; Zinc; Zinc-finger | no_data | Beta strand (2); Chain (1); Compositional bias (2); Domain (1); [NAME] (5); Modified residue (3); Turn (1); Zinc finger (1) | IPR001606 | no_data | ATP-dependent chromatin remodeling; DNA binding; SWI/SNF complex; general [NAME] polymerase II transcription factor activity; metal ion binding; positive regulation of transcription; DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription | GO:0043044; GO:0003677; GO:0016514; GO:0016251; GO:0046872; GO:0045893; GO:0006357; GO:0006350 | 4932 | False | False | False | False | 1kkxA00 1kn5A00 | 100 | SOLUTION NMR | SOLUTION NMR | -267.362750231 | -261.463109583
1654 | 7.42 | P83917 | CBX1_MOUSE | Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25) | [NAME] | Mus musculus (Mouse) | 73 | 185 | Nucleus. | no_data | no_data | 3D-structure; [NAME]; [NAME]; Repeat | Itself; Q9QWF0; P68433; [NAME]; Q13263 | Beta strand (5); Binding site (16); Chain (1); Domain (2); [NAME] (4); Modified residue (2); Mutagenesis (4); Turn (1) | IPR017984; IPR008251; IPR018125; IPR000953; IPR016197 | no_data | [NAME]; chromatin assembly or disassembly; chromatin binding; chromocenter; female pronucleus; identical protein binding; male pronucleus; negative regulation of transcription; DNA-dependent; transcription repressor activity | GO:0005721; GO:0006333; GO:0003682; GO:0010369; GO:0001939; GO:0042802; GO:0001940; GO:0045892; GO:0016564 | 10090 | True | False | False | True | 1ap0A00 1guwA00 | 100 | SOLUTION NMR | SOLUTION NMR | -170.325325712 | -166.072082555
4413 | 3.7 | Q12830 | BPTF_HUMAN | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz-50 clone 1 protein) | BPTF FAC1 FALZ | Homo sapiens (Human) | 62 | 3046 | Cytoplasm. Nucleus. | PBTF family | no_data | 3D-structure; Acetylation; Alternative splicing; Bromodomain; Chromatin regulator; Coiled coil; Complete proteome; Cytoplasm; Metal-binding; [NAME]; [NAME]; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger | no_data | Alternative sequence (2); Beta strand (2); Binding site (4); Chain (1); Coiled coil (4); Compositional bias (6); Domain (2); Frameshift (1); [NAME] (9); Modified residue (14); Mutagenesis (7); Region (2); Sequence caution (2); [NAME] conflict (20); Turn (4); Zinc finger (2) | IPR001487; IPR018359; IPR004022; IPR018500; IPR018501; IPR019786; IPR001965; IPR019787 | no_data | brain development; chromatin remodeling; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of gene-specific transcription; sequence-specific DNA binding; transcription; transcription factor binding; transcription regulator activity; zinc ion binding | GO:0007420; GO:0006338; GO:0005737; GO:0000122; GO:0005634; GO:0043193; GO:0043565; GO:0006350; GO:0008134; GO:0030528; GO:0008270 | 9606 | True | False | False | False | 2fuiA00 2fuuA00 | 100 | SOLUTION NMR | SOLUTION NMR | -124.118636555 | -120.480242836
1086 | 2.17 | P27999 | RPB9_YEAST | DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit 9) (DNA-directed RNA polymerase II 14.2 kDa polypeptide) (B12.6) | RPB9 YGL070C | Saccharomyces cerevisiae ([NAME]'s yeast) | 76 | 122 | Nucleus. | Archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family | no_data | 3D-structure; [NAME] proteome; DNA damage; DNA repair; DNA-directed RNA polymerase; Direct protein sequencing; Metal-binding; [NAME]; [NAME]; Transcription; Zinc; Zinc-finger | P07273; P61830; P40027; P32645 | Beta strand (9); Chain (1); [NAME] (1); Metal binding (8); Modified residue (3); Turn (3); Zinc finger (2) | IPR019761; IPR001529; IPR001222 | no_data | DNA binding; DNA-directed RNA polymerase II; core complex; DNA-directed RNA polymerase activity; protein binding; regulation of transcription; response to drug; transcription initiation from RNA polymerase II promoter; transcription regulator activity; transcription-coupled nucleotide-excision repair; zinc ion binding | GO:0003677; GO:0005665; GO:0003899; GO:0005515; GO:0045449; GO:0042493; GO:0006367; GO:0030528; GO:0006283; GO:0008270 | 4932 | False | False | True | True | 1y1vI02 2e2hI02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -151.819849416 | -156.310555795
3736 | 5.39 | Q9SK39 | SBP3_ARATH | Probable steroid-binding protein 3 (AtMP3) | MP3 At2g24940 F27C12.14 | Arabidopsis [NAME] (Mouse-ear cress) | 109 | 100 | Nucleus. | Cytochrome b5 family; MAPR subfamily | no_data | 3D-structure; [NAME] proteome; Lipid-binding; [NAME]; Steroid-binding | no_data | Beta strand (6); Chain (1); Domain (1); [NAME] (5); Region (1); Turn (1) | IPR001199 | no_data | heme binding; nucleus; steroid binding | GO:0020037; GO:0005634; GO:0005496 | 3702 | False | False | False | False | 1t0gA00 1sv7A00 | 100 | SOLUTION NMR | NMR, 21 STRUCTURES | -339.737890321 | -346.203505926
4779 | 3.43 | Q16512 | PKN1_HUMAN | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C-like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha) (Protease-activated kinase 1) (PAK-1) | PKN1 PAK1 PKN PRK1 PRKCL1 | Homo sapiens (Human) | 81 | 942 | Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. | Protein kinase superfamily; [NAME]/Thr protein kinase family; PKC subfamily | no_data | 3D-structure; ATP-binding; Acetylation; Alternative splicing; Cell membrane; Chromatin regulator; [NAME] proteome; Cytoplasm; Endosome; [NAME]; Membrane; Nucleotide-binding; [NAME]; [NAME]; Polymorphism; Repeat; Serine/threonine-protein kinase; Transcription; Transcription regulation; Transferase | P46734; [NAME]; P53778; [NAME]; Q9NYL2-1; P61586 | Active site (1); Alternative sequence (3); Beta strand (1); Binding site (1); Chain (1); Domain (3); [NAME] (5); Initiator methionine (1); Modified residue (15); Mutagenesis (7); Natural variant (10); Nucleotide binding (1); Repeat (3); [NAME] conflict (8); Site (3) | IPR000961; IPR000008; [NAME]; IPR000861; IPR011072; IPR011009; IPR017892; IPR000719; IPR017441; IPR017442; IPR008271; IPR002290 | 2.7.11.13 | ATP binding; activation of JUN kinase activity; cytoplasm; plasma membrane; protein binding; protein kinase C activity | GO:0005524; GO:0007257; GO:0005737; GO:0005886; GO:0005515; GO:0004697 | 9606 | True | False | False | False | 1urfA00 2rmkB00 | 100 | SOLUTION NMR | SOLUTION NMR | -264.258335467 | -269.12141851
1001 | 2.87 | P07156 | HMGB1_CRIGR | High mobility group protein B1 (High mobility group protein 1) (HMG-1) (Fragment) | HMGB1 HMG-1 HMG1 | Cricetulus griseus (Chinese hamster) | 79 | 180 | Nucleus. | HMGB family | no_data | 3D-structure; Chromosomal protein; DNA-binding; Isopeptide bond; [NAME]; [NAME]; Repeat; [NAME] conjugation | no_data | Chain (1); Compositional bias (1); Cross-link (1); DNA binding (2); [NAME] (3); Modified residue (1); Non-terminal residue (1); Turn (3) | IPR017967; IPR000910; IPR000135; IPR009071 | no_data | DNA binding; base-excision repair; DNA ligation; condensed chromosome; negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; nucleus; protein binding | GO:0003677; GO:0006288; GO:0000793; GO:0017055; GO:0005634; GO:0005515 | 10029 | False | False | False | False | 1hsnA00 1nhnA00 | 100 | SOLUTION NMR | SOLUTION NMR | -219.988114698 | -224.734958667
832 | 5.33 | P30153 | 2AAA_HUMAN | Serine/threonine-protein phosphatase 2A 65 [NAME] regulatory subunit A alpha isoform ([NAME] subunit A isoform PR65-alpha) ([NAME] subunit A isoform R1-alpha) (Medium tumor antigen-associated 61 kDa protein) | [NAME] | Homo sapiens (Human) | 588 | 589 | Centromere. | Phosphatase 2A regulatory subunit A family | no_data | 3D-structure; Acetylation; Centromere; Chromosome partition; [NAME] proteome; Direct protein sequencing; Polymorphism; Repeat | P03081; Q9NSA3; Q14164; Q8TCG1; P23508; P53816; P67775; Q13362-1; Q13362-2; Q60996-3; P60510; Q5T5B3; O43815 | Chain (1); [NAME] (53); Initiator methionine (1); Modified residue (2); Natural variant (1); Region (4); Repeat (15); [NAME] conflict (4); Turn (4) | IPR011989; IPR016024; IPR000357; IPR021133 | no_data | RNA splicing; antigen binding; ceramide metabolic process; chromosome segregation; chromosome; centromeric region; cytosol; inactivation of MAPK activity; induction of apoptosis; membrane; [NAME]; mitochondrion; negative regulation of cell growth; negative regulation of tyrosine phosphorylation of Stat3 protein; nucleus; protein amino acid dephosphorylation; protein complex assembly; protein heterodimerization activity; protein phosphatase type 2A complex; protein phosphatase type 2A regulator activity; regulation of DNA replication; regulation of Wnt receptor signaling pathway; regulation of cell adhesion; regulation of cell differentiation; regulation of transcription; response to organic substance; second-messenger-mediated signaling; soluble fraction | GO:0008380; GO:0003823; GO:0006672; GO:0007059; GO:0000775; GO:0005829; GO:0000188; GO:0006917; GO:0016020; GO:0015630; [NAME]; GO:0030308; GO:0042518; GO:0005634; GO:0006470; GO:0006461; GO:0046982; GO:0000159; GO:0008601; GO:0006275; GO:0030111; GO:0030155; GO:0045595; GO:0045449; GO:0010033; GO:0019932; GO:0005625 | 9606 | False | True | True | True | 1b3uA00 2ie4A00 | 98.8095 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1961.49384537 | -1926.0906726
1114 | 4.09 | P46937 | YAP1_HUMAN | [NAME] homolog (65 kDa Yes-associated protein) (YAP65) | YAP1 YAP65 | Homo sapiens (Human) | 40 | 504 | Cytoplasm. Nucleus. | YORKIE family | no_data | 3D-structure; Activator; Alternative splicing; [NAME] proteome; Cytoplasm; [NAME]; [NAME]; Proto-oncogene; Repeat; Repressor; Transcription; Transcription regulation | Q15797 | Alternative sequence (3); Beta strand (3); Chain (1); Compositional bias (1); Domain (2); Modified residue (18); Mutagenesis (8); Region (1); Turn (2) | IPR001202 | no_data | cell proliferation; contact inhibition; cytoplasm; nucleus; transcription coactivator activity; transcription corepressor activity | GO:0008283; GO:0060242; GO:0005737; GO:0005634; GO:0003713; GO:0003714 | 9606 | False | False | False | False | 1k9qA00 1k9rA00 | 100 | SOLUTION NMR | SOLUTION NMR | -84.587600822 | -82.1768909935
99 | 2.32 | Q9FCA6 | Q9FCA6_STRCO | Putative cytochrome P450 | [NAME] 2SCG58.07 | Streptomyces coelicolor | 402 | 404 | no_data | Cytochrome P450 family | no_data | Complete proteome; Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase | no_data | no_data | IPR001128; IPR002397; IPR017972 | no_data | electron carrier activity; heme binding; monooxygenase activity; oxidation reduction | GO:0009055; GO:0020037; GO:0004497; GO:0055114 | 1902 | False | False | False | False | 1se6B00 2d0eA00 | 99.505 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1317.73831042 | -1293.35038125
1465 | 2.5 | P00735 | THRB_BOVIN | [NAME] (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] | F2 | [NAME] taurus ([NAME]) | 109 | 625 | Secreted ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº extracellular space. | [NAME] family | no_data | 3D-structure; Acute phase; Blood coagulation; Calcium; Cleavage on pair of basic residues; Direct protein sequencing; Disulfide bond; Gamma-carboxyglutamic acid; [NAME]; [NAME]; [NAME]; Protease; Repeat; Secreted; Serine protease; Signal; Zymogen | Q4W8J9 | Active site (3); Beta strand (28); Chain (3); Disulfide bond (12); Domain (4); Glycosylation (3); [NAME] (16); Modified residue (10); Natural variant (1); [NAME] (2); Propeptide (1); Region (1); [NAME] conflict (7); Signal peptide (1); Site (3); Turn (10) | IPR002383; IPR000294; IPR000001; IPR013806; [NAME]; IPR018059; IPR018114; IPR001254; IPR001314; IPR012051; IPR003966; IPR009003; IPR018992 | 3.4.21.5 | acute-phase response; calcium ion binding; extracellular space; proteolysis | GO:0006953; GO:0005509; GO:0005615; GO:0006508 | 9913 | True | True | True | True | 1bbrE00 1vitG00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -264.102393526 | -270.856548938
2476 | 2.09 | P18468 | HB2I_MOUSE | H-2 class II histocompatibility antigen, I-A beta chain | 0 | Mus musculus (house mouse) | 97 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | False | True | True | True | 1ktdB02 1r5vB02 | 98.9691 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -271.291970301 | -265.209148963
3185 | 2.33 | Q96EP1 | CHFR_HUMAN | E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) ([NAME] with forkhead and RING finger domains protein) (RING finger protein 196) | CHFR RNF196 | Homo sapiens (Human) | 113 | 664 | Nucleus. | CHFR family | Protein modification; protein ubiquitination. | 3D-structure; ADP-ribosylation; Alternative splicing; Cell cycle; Cell division; [NAME] proteome; Ligase; Metal-binding; Mitosis; [NAME]; [NAME]; Polymorphism; [NAME] conjugation; [NAME] conjugation pathway; Zinc; Zinc-finger | P13693 | Alternative sequence (4); Beta strand (12); Chain (1); Domain (1); [NAME] (1); Modified residue (2); Mutagenesis (9); Natural variant (7); [NAME] conflict (4); Turn (1); Zinc finger (2) | IPR000253; IPR008984; IPR001841; IPR017907 | 6.3.2.- | PML body; cell division; mitosis; mitotic cell cycle checkpoint; nucleotide binding; protein binding; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding | GO:0016605; GO:0051301; GO:0007067; GO:0007093; GO:0000166; GO:0005515; GO:0000209; GO:0004842; GO:0008270 | 9606 | False | True | False | False | 1lgpA00 1lgqA00 | 99.115 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -282.630241874 | -275.493401054
2614 | 3.11 | P40223 | CSF3R_MOUSE | [NAME] colony-stimulating factor receptor (G-CSF receptor) (G-CSF-R) (CD antigen CD114) | Csf3r Csfgr | Mus musculus (Mouse) | 109 | 837 | Membrane; Single-pass type I membrane protein. | Type I cytokine receptor family; Type 2 subfamily | no_data | 3D-structure; Cell adhesion; Disulfide bond; [NAME]; Immunoglobulin domain; Membrane; Receptor; Repeat; Signal; [NAME] | no_data | Beta strand (15); Chain (1); Disulfide bond (7); Domain (6); Glycosylation (11); [NAME] (4); [NAME] (2); Signal peptide (1); Topological domain (2); [NAME] (1); Turn (1) | IPR008957; IPR003961; IPR003529; IPR010457 | no_data | cell adhesion; cytokine receptor activity; integral to membrane; neutrophil chemotaxis | GO:0007155; GO:0004896; GO:0016021; GO:0030593 | 10090 | False | False | False | False | 1ctoA00 1gcfA00 | 100 | SOLUTION NMR | SOLUTION NMR | -215.370495648 | -222.413304183
1665 | 4.71 | P00644 | NUC_STAAU | [NAME] (TNase) (EC 3.1.31.1) (Micrococcal nuclease) (Staphylococcal nuclease) [Cleaved into: Nuclease B; Nuclease A] | nuc | Staphylococcus aureus | 136 | 231 | Secreted.  [NAME]. | [NAME] family | no_data | 3D-structure; Calcium; Direct protein sequencing; Endonuclease; Hydrolase; Membrane; Metal-binding; Nuclease; Secreted; Signal; Zymogen | no_data | Active site (3); Beta strand (6); Chain (2); Erroneous initiation (1); [NAME] (4); Metal binding (3); Propeptide (2); Signal peptide (1); Turn (2) | IPR016071; IPR006021; IPR002071 | 3.1.31.1 | endonuclease activity; extracellular region; membrane; metal ion binding; nucleic acid binding | GO:0004519; GO:0005576; GO:0016020; GO:0046872; GO:0003676 | 1280 | True | False | False | True | 1joqA00 1jorA00 | 100 | SOLUTION NMR | SOLUTION NMR | -433.431442935 | -442.421293194
2526 | 3.01 | Q13477 | MADCA_HUMAN | Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1) | MADCAM1 | Homo sapiens (Human) | 90 | 382 | Membrane; Single-pass type I membrane protein. | no_data | no_data | 3D-structure; Alternative splicing; Cell adhesion; [NAME] proteome; Disulfide bond; [NAME]; Immunoglobulin domain; Membrane; Polymorphism; Repeat; Signal; [NAME] | no_data | Alternative sequence (1); Beta strand (16); Chain (1); Disulfide bond (3); Domain (2); Glycosylation (1); [NAME] (1); Natural variant (2); Region (2); Repeat (6); [NAME] conflict (5); Signal peptide (1); Topological domain (2); [NAME] (1) | IPR015169; IPR007110; IPR013783; IPR003599 | no_data | cell adhesion; immune response; integral to membrane; membrane fraction; plasma membrane; protein binding; signal transduction | GO:0007155; GO:0006955; GO:0016021; GO:0005624; GO:0005886; GO:0005515; GO:0007165 | 9606 | False | True | False | False | 1gsmA01 1bqsA01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -249.145476106 | -255.178016791
6193 | 2.89 | Q05506 | SYRC_YEAST | [NAME]-tRNA synthetase; cytoplasmic (EC 6.1.1.19) (Arginine--tRNA ligase) (ArgRS) | YDR341C D9651.10 | Saccharomyces cerevisiae ([NAME]'s yeast) | 347 | 607 | Cytoplasm. | Class-I aminoacyl-tRNA synthetase family | no_data | 3D-structure; ATP-binding; Aminoacyl-tRNA synthetase; [NAME] proteome; Cytoplasm; Ligase; Nucleotide-binding; [NAME]; Protein biosynthesis | no_data | Beta strand (14); Chain (1); [NAME] (35); Modified residue (1); [NAME] (1); Turn (6) | IPR001412; IPR001278; IPR015945; IPR005148; IPR008909; IPR014729; [NAME] | 6.1.1.19 | ATP binding; arginine-tRNA ligase activity; arginyl-tRNA aminoacylation; mitochondrion | GO:0005524; GO:0004814; GO:0006420; GO:0005739 | 4932 | False | True | True | True | 1bs2A01 1f7vA01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -1124.25722038 | -1147.63088476
5538 | 2.25 | P35804 | BLIP_STRCL | Beta-lactamase inhibitory protein (BLIP) | no_data | Streptomyces clavuligerus | 91 | 201 | Secreted. | no_data | no_data | 3D-structure; Direct protein sequencing; Disulfide bond; Repeat; Secreted; Signal | no_data | Beta strand (8); Chain (1); Disulfide bond (2); [NAME] (6); Repeat (2); Signal peptide (1); Turn (2) | IPR009099 | no_data | extracellular region | GO:0005576 | 1901 | True | True | False | True | 2b5rC02 2g2wB02 | 98.9011 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -271.778090948 | -277.940521609
3834 | 3.27 | P0AAS7 | YBCJ_ECOLI | Uncharacterized protein ybcJ | ybcJ b0528 JW5070 | Escherichia coli (strain K12) | 79 | 70 | no_data | no_data | no_data | 3D-structure; [NAME] proteome; RNA-binding | no_data | Beta strand (4); Chain (1); Domain (1); Erroneous initiation (2); Frameshift (1); [NAME] (2) | IPR002942 | no_data | RNA binding | GO:0003723 | 83333 | False | False | False | False | 1p9kA00 1o09A00 | 100 | SOLUTION NMR | NMR, 10 STRUCTURES | -187.621931633 | -193.02139188
967 | 3.36 | Q05783 | HMGD_DROME | High mobility group protein D (HMG-D) | HmgD CG17950 | Drosophila melanogaster (Fruit fly) | 73 | 112 | Nucleus. | HMGB family | no_data | 3D-structure; Chromosomal protein; [NAME] proteome; DNA-binding; Direct protein sequencing; [NAME]; [NAME] | Q9W354 | Chain (1); Compositional bias (1); DNA binding (1); [NAME] (3); Modified residue (4); Turn (1) | IPR000910; IPR009071 | no_data | AT DNA binding; DNA bending activity; chromatin organization; chromosome; dendrite morphogenesis; muscle organ development; nucleus; protein binding | GO:0003680; GO:0008301; GO:0006325; GO:0005694; GO:0048813; GO:0007517; GO:0005634; GO:0005515 | 7227 | False | False | False | True | 1qrvA00 1e7jA00 | 98.6487 | X-RAY DIFFRACTION | SOLUTION NMR | -221.365908964 | -216.223834238
5860 | 2.75 | P45947 | ARSC_BACSU | Protein arsC (Arsenate reductase) (EC 1.20.4.-) (Arsenical pump modifier) (Low molecular weight protein-tyrosine-phosphatase) (EC 3.1.3.48) | arsC yqcM [NAME] | Bacillus subtilis | 137 | 139 | no_data | Low molecular weight phosphotyrosine protein phosphatase superfamily; [NAME] family | no_data | 3D-structure; Arsenical resistance; [NAME] proteome; Disulfide bond; [NAME]; Oxidoreductase; Redox-active center | no_data | Active site (3); Beta strand (4); Chain (1); Disulfide bond (2); [NAME] (6) | IPR014064; IPR017867 | 1.20.4.-; 3.1.3.48 | arsenate reductase (thioredoxin) activity; oxidation reduction; protein amino acid dephosphorylation; protein tyrosine phosphatase activity; response to arsenic | GO:0030612; GO:0055114; GO:0006470; GO:0004725; GO:0046685 | 1423 | False | False | False | True | 1z2dA00 1z2eA00 | 100 | SOLUTION NMR | SOLUTION NMR | -451.732253167 | -441.980616737
4674 | 2.59 | P26281 | HPPK_ECOLI | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (7;8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7;8-dihydropterin pyrophosphokinase) (PPPK) | folK b0142 [NAME] | Escherichia coli (strain K12) | 158 | 159 | no_data | HPPK family | Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7;8-dihydropteridine diphosphate from 7;8-dihydroneopterin triphosphate: step 4/4. | 3D-structure; ATP-binding; [NAME] proteome; Direct protein sequencing; Folate biosynthesis; [NAME]; Nucleotide-binding; Transferase | no_data | Beta strand (7); Chain (1); [NAME] (5); Initiator methionine (1) | IPR000550 | 2.7.6.3 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity; ATP binding; folic acid biosynthetic process; kinase activity | GO:0003848; GO:0005524; GO:0046656; GO:0016301 | 83333 | False | False | False | True | 1f9hA00 1kbrA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -486.258769808 | -474.923748299
680 | 3.73 | P30114 | GST28_SCHHA | Glutathione S-transferase class-mu 28 kDa isozyme (GST 28) (EC 2.5.1.18) (Sh28GST) | no_data | Schistosoma haematobium (Blood fluke) | 124 | 211 | no_data | GST superfamily; [NAME] family | no_data | 3D-structure; Transferase | no_data | Active site (1); Beta strand (5); Chain (1); Domain (2); [NAME] (12); Turn (1) | IPR010987; IPR004045; IPR017933; IPR004046; IPR012336; IPR012335 | 2.5.1.18 | glutathione transferase activity | GO:0004364 | 6185 | True | False | False | True | 2caiA02 2c80A02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -408.634758567 | -417.625263266
2799 | 4.07 | P00588 | [NAME] | [NAME] toxin (DT) (NAD(+)--diphthamide ADP-ribosyltransferase) (EC 2.4.2.36) [Cleaved into: [NAME] toxin fragment A; [NAME] toxin fragment B] | no_data | Corynephage beta | 155 | 567 | no_data | no_data | no_data | 3D-structure; Cleavage on pair of basic residues; Direct protein sequencing; Disulfide bond; Glycosyltransferase; NAD; Signal; [NAME]; Transferase | no_data | Active site (1); Beta strand (25); Binding site (2); Chain (2); Disulfide bond (2); Erroneous initiation (1); [NAME] (28); [NAME] conflict (1); Signal peptide (1); Site (1); Turn (4) | IPR000512 | 2.4.2.36 | NAD+-diphthamide ADP-ribosyltransferase activity; extracellular region; pathogenesis | GO:0047286; GO:0005576; [NAME] | 10703 | False | True | True | False | 1f0lB03 1xdtT03 | 99.3548 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -476.238814231 | -487.515799829
6154 | 2.51 | O59072 | GUAAB_PYRHO | GMP synthase [glutamine-hydrolyzing] subunit B (EC 6.3.5.2) (GMP synthetase) | guaAB PH1347 | Pyrococcus horikoshii | 164 | 308 | no_data | no_data | Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. | 3D-structure; ATP-binding; [NAME] proteome; GMP biosynthesis; Ligase; Nucleotide-binding; Purine biosynthesis | no_data | Beta strand (10); Chain (1); Domain (1); [NAME] (11); Nucleotide binding (1); Turn (3) | IPR001674; IPR022310; IPR014729 | 6.3.5.2 | ATP binding; GMP biosynthetic process; GMP synthase (glutamine-hydrolyzing) activity | GO:0005524; GO:0006177; GO:0003922 | 53953 | False | False | False | False | 2dplA01 2z0cA01 | 98.1707 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -564.228447919 | -552.275323436
937 | 2.79 | P01130 | [NAME] | Low-density lipoprotein receptor (LDL receptor) | LDLR | Homo sapiens (Human) | 41 | 860 | Membrane; Single-pass type I membrane protein. Membrane ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº clathrin-coated pit; Single-pass type I membrane protein. | [NAME] family | no_data | 3D-structure; Cholesterol metabolism; Coated pit; [NAME] proteome; Direct protein sequencing; Disease mutation; Disulfide bond; EGF-like domain; Endocytosis; [NAME]; Host-virus interaction; LDL; Lipid metabolism; Lipid transport; Membrane; [NAME]; Polymorphism; Receptor; Repeat; Signal; Steroid metabolism; [NAME]; Transport | no_data | Beta strand (46); Chain (1); Disulfide bond (30); Domain (10); Glycosylation (5); [NAME] (7); Modified residue (2); [NAME] (1); Mutagenesis (3); Natural variant (155); Region (1); Repeat (6); Signal peptide (1); Topological domain (2); [NAME] (1); Turn (12) | IPR011042; IPR006210; IPR013032; IPR000152; IPR000742; IPR001881; IPR013091; IPR018097; IPR002172; IPR000033 | no_data | calcium ion binding; cholesterol homeostasis; [NAME] process; clathrin-coated endocytic vesicle membrane; coated pit; endocytosis; endosome membrane; integral to plasma membrane; interspecies interaction between organisms; intestinal cholesterol absorption; low-density lipoprotein particle; low-density lipoprotein particle clearance; low-density lipoprotein receptor activity; protein amino acid O-linked glycosylation; very-low-density lipoprotein receptor activity | GO:0005509; GO:0042632; GO:0008203; GO:0030669; GO:0005905; GO:0006897; GO:0010008; GO:0005887; GO:0044419; GO:0030299; GO:0034362; GO:0034383; GO:0005041; GO:0006493; GO:0030229 | 9606 | False | False | False | True | 1hj7A01 1hz8A01 | 100 | SOLUTION NMR | SOLUTION NMR | -77.5955668392 | -80.6228394129
20 | 3.72 | P0C216 | PHLC1_CLOPE | Phospholipase C (PLC) (EC 3.1.4.3) (Phosphatidylcholine cholinephosphohydrolase) (Alpha-toxin) (Hemolysin) (Lecithinase) | plc cpa CPE0036 | Clostridium perfringens | 250 | 398 | Secreted. | Bacterial zinc-metallophospholipase C family | no_data | 3D-structure; Calcium; Complete proteome; Cytolysis; Hemolysis; Hydrolase; Metal-binding; Secreted; Signal; [NAME]; Virulence; Zinc | no_data | Beta strand (10); Chain (1); Domain (2); [NAME] (13); Metal binding (22); Mutagenesis (15); Natural variant (22); Region (1); Signal peptide (1); Turn (22) | IPR008976; IPR000907; IPR001024; IPR008947; IPR001531 | 3.1.4.3 | cytolysis; extracellular region; hemolysis by symbiont of host erythrocytes; pathogenesis; phosphatidylcholine phospholipase C activity; zinc ion binding | GO:0019835; GO:0005576; GO:0019836; [NAME]; [NAME]; GO:0008270 | 1502 | False | False | True | False | 1ca1A01 1gygA01 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -869.242741488 | -850.738662484
6609 | 2.38 | P0A786 | PYRB_ECOLI | Aspartate carbamoyltransferase catalytic chain (EC 2.1.3.2) (Aspartate transcarbamylase) (ATCase) | pyrB b4245 JW4204 | Escherichia coli (strain K12) | 158 | 311 | no_data | ATCase/OTCase family | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. | 3D-structure; [NAME] proteome; Direct protein sequencing; Pyrimidine biosynthesis; Transferase | no_data | Beta strand (13); Chain (1); [NAME] (16); Initiator methionine (1); [NAME] conflict (12); Turn (6) | IPR006132; IPR006130; IPR006131; IPR002082 | 2.1.3.2 | de novo' pyrimidine base biosynthetic process; amino acid binding; aspartate carbamoyltransferase activity; cellular amino acid metabolic process; cytoplasm; pyrimidine nucleotide biosynthetic process | GO:0006207; GO:0016597; GO:0004070; GO:0006520; GO:0005737; GO:0006221 | 83333 | True | False | False | False | 1acmA02 3at1A02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -512.895681451 | -501.157765355
662 | 5.62 | Q09472 | EP300_HUMAN | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) | EP300 P300 | Homo sapiens (Human) | 101 | 2414 | Nucleus. | no_data | no_data | 3D-structure; Acetylation; Bromodomain; Cell cycle; Chromosomal rearrangement; Citrullination; Complete proteome; Direct protein sequencing; Disease mutation; Host-virus interaction; Metal-binding; [NAME]; [NAME]; [NAME]; Polymorphism; Transcription; Transcription regulation; Transferase; [NAME] conjugation; Zinc; Zinc-finger | Q99967; Q99814; Q16665; P84051; P02299; P84040; P17181; P48551; Q9QXM1; Q92831; P01106; P55209; Q9Y6Q9; P20265; P37231; P05549; P04637; P02340; Q13105 | Beta strand (10); Chain (1); Compositional bias (4); Domain (2); [NAME] (19); Initiator methionine (1); Modified residue (34); [NAME] (1); Mutagenesis (12); Natural variant (8); Region (3); [NAME] conflict (4); Site (3); Turn (2); Zinc finger (3) | IPR001487; IPR018359; IPR010303; IPR003101; IPR009110; IPR014744; IPR000197; IPR000433 | 2.3.1.48 | N-terminal peptidyl-lysine acetylation; apoptosis; cell cycle; cytoplasm; histone H4 acetylation; histone acetyltransferase activity; interspecies interaction between organisms; nervous system development; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; response to hypoxia; transcription; transcription coactivator activity; zinc ion binding | GO:0018076; GO:0006915; GO:0007049; GO:0005737; GO:0043967; GO:0004402; GO:0044419; GO:0007399; GO:0051091; GO:0045944; [NAME]; GO:0006350; GO:0003713; GO:0008270 | 9606 | False | False | False | False | 1l3eB00 1p4qB00 | 100 | SOLUTION NMR | SOLUTION NMR | -258.966200087 | -266.480147631
4462 | 2.13 | P04049 | RAF1_HUMAN | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | [NAME] | Homo sapiens (Human) | 52 | 648 | no_data | Protein kinase superfamily; TKL Ser/Thr protein kinase family; RAF subfamily | no_data | 3D-structure; ATP-binding; Alternative splicing; [NAME] proteome; Direct protein sequencing; Disease mutation; [NAME]; Metal-binding; Nucleotide-binding; [NAME]; Polymorphism; Proto-oncogene; [NAME]/threonine-protein kinase; Transferase; Zinc; Zinc-finger | P15056; [NAME]; P30304; Q9UNS2; P31327; [NAME]; P08238; P11021; Q9NVR2; Q02750; O43482; Q13177; P14618; P62834; P53805-2; Q3ZCQ8; P31946; P61981; Q04917; P27348; P63104 | Active site (1); Alternative sequence (1); Beta strand (9); Binding site (1); Chain (1); Domain (2); [NAME] (4); Metal binding (8); Modified residue (16); Mutagenesis (1); Natural variant (18); Nucleotide binding (1); [NAME] conflict (2); Turn (3); Zinc finger (1) | IPR020454; IPR011009; IPR002219; IPR000719; IPR017441; IPR003116; IPR001245; IPR008271 | 2.7.11.1 | ATP binding; [NAME] protein signal transduction; apoptosis; cell proliferation; cytosol; metal ion binding; mitochondrial outer membrane; negative regulation of cell proliferation; plasma membrane; protein amino acid phosphorylation; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; receptor signaling protein activity | GO:0005524; GO:0007265; GO:0006915; GO:0008283; GO:0005829; GO:0046872; GO:0005741; GO:0008285; GO:0005886; GO:0006468; GO:0005515; GO:0004674; [NAME]; GO:0005057 | 9606 | False | False | False | False | 1faqA00 1farA00 | 100 | SOLUTION NMR | SOLUTION NMR | -94.6077945845 | -98.480794474
558 | 3.94 | P18206 | [NAME] | Vinculin (Metavinculin) | VCL | Homo sapiens (Human) | 129 | 1134 | Cytoplasm ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº cytoskeleton. Cell junction ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. | Vinculin/alpha-catenin family | no_data | 3D-structure; Acetylation; [NAME]-binding; Alternative splicing; [NAME]; Cell adhesion; Cell junction; Cell membrane; [NAME] proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; [NAME]; Membrane; Myristate; Palmitate; [NAME]; Polymorphism; Repeat | P54939 | Alternative sequence (4); Beta strand (1); Chain (1); Compositional bias (1); [NAME] (39); Initiator methionine (1); Modified residue (13); Natural variant (6); Region (2); Repeat (3); Turn (8) | IPR017997; IPR006077; IPR000633 | no_data | [NAME]; [NAME]; alpha-catenin binding; apical junction assembly; cell adhesion; cellular component movement; costamere; cytosol; extracellular region; focal adhesion; lamellipodium assembly; muscle contraction; negative regulation of cell migration; protein complex; structural molecule activity | GO:0003779; GO:0015629; GO:0045294; GO:0043297; GO:0007155; GO:0006928; GO:0043034; GO:0005829; GO:0005576; GO:0005925; GO:0030032; GO:0006936; GO:0030336; GO:0043234; GO:0005198 | 9606 | False | False | True | True | 1ydiA02 2gwwA02 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -430.461764659 | -420.73488985
4532 | 2.42 | Q04656 | ATP7A_HUMAN | Copper-transporting ATPase 1 (EC 3.6.3.4) (Copper pump 1) (Menkes disease-associated protein) | [NAME] MNK | Homo sapiens (Human) | 79 | 1500 | Golgi apparatus ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.  Cytoplasm ÃƒÆ’Ã†â€™Ãƒâ€ [NAME]™Ãƒâ€šÃ‚Â¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â¬ÃƒÆ’Ã†â€™ÃƒÂ¢Ã¢â€šÂ¬Ã…Â¡ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Âº cytosol.  Endoplasmic reticulum. | Cation transport ATPase (P-type) family; Type IB subfamily | no_data | 3D-structure; ATP-binding; Alternative splicing; Cell membrane; [NAME] proteome; Copper; Copper transport; Cytoplasm; Disease mutation; Endoplasmic reticulum; [NAME]; Golgi apparatus; [NAME]; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; [NAME]; Polymorphism; Repeat; [NAME]; Transport | no_data | Active site (1); Alternative sequence (7); Beta strand (25); Chain (1); Compositional bias (1); Domain (6); Glycosylation (2); [NAME] (15); Metal binding (2); Modified residue (2); [NAME] (1); Mutagenesis (1); Natural variant (37); [NAME] conflict (25); Topological domain (9); [NAME] (8); Turn (13) | IPR001877; IPR008250; IPR006403; IPR006416; IPR001757; IPR018303; IPR006122; IPR005834; IPR017969; IPR006121 | 3.6.3.4 | ATP binding; ATP biosynthetic process; T-helper cell differentiation; basolateral plasma membrane; blood vessel remodeling; cartilage development; cellular copper ion homeostasis; cerebellar Purkinje cell differentiation; collagen fibril organization; copper ion export; copper ion import; copper-dependent protein binding; copper-exporting ATPase activity; cytosol; detoxification of copper ion; dopamine metabolic process; elastic fiber assembly; elastin biosynthetic process; endoplasmic reticulum; epinephrine metabolic process; hair follicle morphogenesis; integral to membrane; late endosome; locomotory behavior; lung alveolus development; mitochondrion organization; negative regulation of metalloenzyme activity; neuron projection; neuron projection morphogenesis; neuronal cell body; neuroprotection; [NAME] process; peptidyl-lysine modification; perinuclear region of cytoplasm; pigmentation; positive regulation of metalloenzyme activity; positive regulation of oxidoreductase activity; pyramidal neuron development; regulation of oxidative phosphorylation; removal of superoxide radicals; serotonin metabolic process; skin development; superoxide dismutase copper chaperone activity; trans-Golgi network; trans-Golgi network transport vesicle; tryptophan metabolic process | GO:0005524; GO:0006754; GO:0042093; GO:0016323; GO:0001974; GO:0051216; GO:0006878; GO:0021702; GO:0030199; GO:0060003; GO:0015677; GO:0032767; GO:0004008; GO:0005829; GO:0010273; GO:0042417; GO:0048251; [NAME]; GO:0005783; GO:0042414; GO:0031069; GO:0016021; GO:0005770; GO:0007626; GO:0048286; GO:0007005; GO:0048553; GO:0043005; GO:0048812; GO:0043025; GO:0043526; GO:0042415; GO:0018205; GO:0048471; GO:0043473; GO:0048554; GO:0051353; GO:0021860; GO:0002082; GO:0019430; GO:0042428; GO:0043588; GO:0016532; [NAME]; GO:0030140; GO:0006568 | 9606 | False | False | False | False | 1kviA00 1kvjA00 | 100 | SOLUTION NMR | SOLUTION NMR | -211.411182248 | -217.396932031
4092 | 2.06 | P0A794 | PDXJ_ECOLI | Pyridoxine 5'-phosphate synthase (PNP synthase) (EC 2.6.99.2) | pdxJ b2564 JW2548 | Escherichia coli (strain K12) | 242 | 243 | Cytoplasm. | PNP synthase family | Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5. | 3D-structure; [NAME] proteome; Cytoplasm; Direct protein sequencing; Pyridoxine biosynthesis; Transferase | no_data | Active site (3); Beta strand (9); Binding site (6); Chain (1); Frameshift (1); [NAME] (11); Initiator methionine (1); Natural variant (1); Region (2); Site (1); Turn (2) | IPR013785; IPR004569 | 2.6.99.2 | cytosol; pyridoxine 5'-phosphate synthase activity; pyridoxine biosynthetic process | GO:0005829; GO:0033856; GO:0008615 | 83333 | False | True | False | True | 1m5wA00 1ixpA00 | 100 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -840.546148289 | -821.778945819
1635 | 3.78 | P51671 | CCL11_HUMAN | Eotaxin (C-C motif chemokine 11) (Small-inducible cytokine A11) ([NAME] chemotactic protein) | CCL11 SCYA11 | Homo sapiens (Human) | 74 | 97 | Secreted. | Intercrine beta (chemokine CC) family | no_data | 3D-structure; [NAME]; [NAME] proteome; Cytokine; Direct protein sequencing; Disulfide bond; [NAME]; Inflammatory response; Polymorphism; Secreted; Signal | no_data | Beta strand (5); Chain (1); Disulfide bond (2); Glycosylation (1); [NAME] (1); Natural variant (5); Signal peptide (1) | IPR000827; IPR001811 | no_data | cell adhesion; cellular calcium ion homeostasis; chemokine activity; chemotaxis; extracellular space; immune response; inflammatory response; positive regulation of Rac GTPase activity; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of endothelial cell proliferation; protein amino acid phosphorylation; response to radiation; response to virus; signal transduction | GO:0007155; GO:0006874; GO:0008009; GO:0006935; GO:0005615; GO:0006955; GO:0006954; GO:0032855; GO:0030838; GO:0030335; GO:0001938; GO:0006468; GO:0009314; GO:0009615; GO:0007165 | 9606 | False | False | False | False | 1eotA00 2eotA00 | 100 | SOLUTION NMR | SOLUTION NMR | -179.697379903 | -173.836082592
6117 | 2.75 | P11215 | ITAM_HUMAN | Integrin alpha-M (Cell surface glycoprotein MAC-1 subunit alpha) (CR-3 alpha chain) ([NAME] adhesion receptor [NAME]) (Neutrophil adherence receptor) (CD11 antigen-like family member B) (CD antigen CD11b) | ITGAM CD11B [NAME] | Homo sapiens (Human) | 184 | 1152 | Membrane; Single-pass type I membrane protein. | Integrin alpha chain family | no_data | 3D-structure; Calcium; Cell adhesion; [NAME] proteome; Direct protein sequencing; Disulfide bond; [NAME]; Integrin; Magnesium; Membrane; Polymorphism; Receptor; Repeat; Signal; Systemic lupus erythematosus; [NAME] | no_data | Beta strand (5); [NAME] binding (3); Chain (1); Disulfide bond (7); Glycosylation (19); [NAME] (12); [NAME] (1); Natural variant (4); Repeat (7); [NAME] conflict (4); Signal peptide (1); Topological domain (2); [NAME] (1); Turn (1) | IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; IPR013513; IPR002035 | no_data | [NAME]; [NAME] signaling pathway; receptor activity | GO:0008305; GO:0007229; GO:0004872 | 9606 | False | False | False | False | 1idoA00 1jlmA00 | 98.3957 | X-RAY DIFFRACTION | X-RAY DIFFRACTION | -630.686892303 | -645.563491975
278 | 2.46 | P03050 | RARC_BPP22 | Transcriptional repressor arc | arc | Enterobacteria phage P22 (Bacteriophage P22) | 53 | 53 | no_data | P22 arc/mnt family | no_data | 3D-structure; DNA-binding; Repressor; Transcription; Transcription regulation | no_data | Beta strand (1); Chain (1); [NAME] (2) | IPR013321; IPR010985 | no_data | DNA binding; regulation of transcription; transcription | GO:0003677; GO:0045449; GO:0006350 | 10754 | False | False | False | False | 1nlaA00 1qtgA00 | 100 | SOLUTION NMR | SOLUTION NMR | -153.604409215 | -149.317547602