Spreadsheet: 563bf933-8a3f-4c13-b756-f3237c54d3fc
Sheet: Sheet1

Table S2. S. mansoni orthologs to human TNF-alpha signaling pathway elements | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12 | Unnamed: 13 | Unnamed: 14 | Unnamed: 15 | Unnamed: 16 | Unnamed: 17 | Unnamed: 18 | Unnamed: 19 | Unnamed: 20 | Unnamed: 21 | Unnamed: 22 | Unnamed: 23 | Unnamed: 24 | Unnamed: 25 | Unnamed: 26 | Unnamed: 27 | Unnamed: 28 | Unnamed: 29 | Unnamed: 30 | Unnamed: 31 | Unnamed: 32 | Unnamed: 33 | Unnamed: 34 | Unnamed: 35 | Unnamed: 36
Human TNF-alpha pathway query |  |  |  | Best human query hit to S. mansoni Genome Prediction |  |  |  |  |  |  | Best human query hit to S. mansoni contigs |  |  |  |  |  | Best contig hit to S. mansoni genome sequence |  |  |  |  | Best contig hit to GenBank Human protein |  |  |  |  |  |  | Best contig hit to GenBank annotated protein |  |  |  |  |  |  | Contig composition
Element | Description | Alternative symbols | Human query | Genome Scaffold | [NAME] | Identity | Similarity | Coverage | Bit score | e-value | Contig | Identity | Similarity | Coverage | Bit score | e-value | Genome Scaffold | contig coordinates (exons) | genomic scaffold coordinates (of exons) | Highest bit score | Highest e-value | Best Human hit | Acession number / Gene id | Identity | Similarity | Coverage | Bit score | e-value | Best annotated hit | Accession number/gene ID | Identity | Similarity | Coverage | Bit score | e-value | ESTs in contig
TRAF 2 | Tumor necrosis factor receptor associated factor 2 (TRAF2) | TRAP | CAI15105 | Smp_scaff000369 | Smp_168390 | 0.27 | 0.46 | 0.92 | 394 | 5.5e-37 | C804436.1 | 0.27 | 0.4 | 0.39 | 152 | 1e-10 | Smp_scaff000369 | 254-593; 33-255 | 43030-42691; 44150-43928 | 668 | 0 | TNF receptor-associated factor 4 [Homo sapiens] | [NAME] | 0.32 | 0.53 | 0.34 | 115 | 2e-24 | PREDICTED: similar to TNF-receptor-associated factor 1 [[NAME] magnipapillata] |  | 0.35 | 0.56 | 0.46 | 137 | 6e-31 | CD116218.1, CD154514.1, CD154512.1, CD116195.1, CD154720.1, CD154447.1, CD154382.1, [NAME], CD116196.1, CD116069.1, EX505084.1, EX510656.1
MAPKKK | Mitogen-activated protein kinase kinase kinases (MAPKKK) (ASK1) | [NAME] | NP_005914.1 | Smp_scaff000258 | Smp_162800.1 | 0.36 | 0.56 | 0.64 | 537 | 3e-156 | C911313.1 | 0.58 | 0.74 | 0.08 | 136 | 4e-32 | Smp_scaff000258 | 1-58; 58-200; 201-295 | 375868 - 375929; 379935-380077;  381902-381997 | 283 | 4e-75 | mitogen-activated protein kinase kinase kinase 5 [Homo sapiens] | GENE ID: 4217 MAP3K5 | 0.59 | 0.75 | 0.09 | 130 | 6e-29 | PREDICTED: similar to mitogen-activated protein kinase kinase kinase 5 [Rattus norvegicus] | ref|XP_001054480.1 | 0.59 | 0.73 | 0.08 | 136 | 8e-31 | CD120270
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | mitogen-activated protein kinase kinase kinase 15 [Homo sapiens] | ref|NP_001001671.2 | 0.59 | 0.73 | 0.15 | 135 | 1e-30 | PREDICTED: similar to Mitogen-activated protein kinase kinase kinase 15 (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) [[NAME] taurus] | ref|XP_607781.4 | 0.59 | 0.74 | 0.09 | 136 | 6e-31
JNKK | c-Jun N-terminal kinase kinases (JNKK) | SERK1, MAPKK4, MEK4,PRKMK4 | P45985 | Smp_scaff000394 | Smp_086690 | 0.64 | 0.78 | 0.81 | 915 | 6e-103 | C812624.1 | 0.56 | 0.68 | 0.78 | 388 | 1e-108 | Smp_scaff000394 | 1-63; 82-328; 393-822; 822-1194; 1194-1323; 1322-1373; 1374-1615; 1624-1722; 1721-1782; 1782-1876 | 200506-200568; 200608-200853;  200918-201347; 203796-204168; 206924-207053; 209817-209868; 214928-215169; 218941-219049; 219981-220042; 220182-220276 | 831 | 0 | MAP2K4 [Homo sapiens] | CAG38801.1 | 0.56 | 0.69 | 0.76 | 377 | 4e-103 | Map2k4 protein [[NAME] laevis] | gb|AAI26010.1 | 0.56 | 0.69 | 0.64 | 379 | 1e-103 | CD078303. 2, CD078391.2, CD072953.1, AI975905.1, CD119278.1, [NAME], AI740233.1, CD128151.1, CD195662.1, EX710779.1, EX710712.1, EX716749.1, EX716748.1, EX713103.1
JNK | c-Jun N-terminal kinase (JNK) | SAPK1, PRKM8, | NP_620637.1 | Smp_scaff000431 | Smp_172240 | 0.69 | 0.8 | 0.84 | 1321 | 3.3e-135 | C804296.1 | 0.71 | 0.78 | 0.31 | 207 | 3e-54 | Smp_scaff000431 | 1-44; 43-333; 333-400 | 390400-390443; 392478-392768; 394460-394547 | 577 | e-163 | unnamed protein product [Homo sapiens] | BAG51956.1 | 0.71 | 0.79 | 0.49 | 202 | 2e-50 | c-Jun N-terminal kinase JNK [Aplysia californica] | AAP42290.1 | 0.71 | 0.81 | 0.33 | 208 | 3e-52 | CD156514.1, CD192070.1
c-JUN | [NAME] avian sarcoma virus 17 oncogene homolog (c-Jun) | AP1 | P05412.2 | Smp_scaff000301 | Smp_080420 | 0.42 | 0.6 | 0.59 | 148 | 1.9e-16 | C812910.1 | 0.42 | 0.6 | 0.22 | 54 | 4e-08 | Smp_scaff000301 | 31-1444;  1445-1682 | 261142-262555; 262591-262828 | 2803 | 0 | JUN [Homo sapiens] | emb|CAG46525.1 | 0.42 | 0.6 | 0.22 | 62.8 | 7e-08 | PREDICTED: similar to Jun-B oncogene [Monodelphis domestica] | ref|XP_001362664.1 | 0.45 | 0.62 | 0.19 | 65.5 | 1e-08 | CD079470.2, [NAME], CD079021.2, CD073472.1, CD095290.1, CD069097.1, CD066563.1, [NAME], CD118918.1, CD188814.1, CD160995.1, CD185043.1, CD185080.1, CD163232.1, CD201607.1, AI395529.1, CD141572.1, EX714220.1, EX714210.1, EX716556.1, CD067518.1, EX714296.1, EX716504.1, BG932383.1, EX712818.1, CD168291.1, BG930874.1, [NAME], [NAME], EX712378.1, EX712327.1, EX716351.1
A20 | A20 (A20) - like | TNFAIP3, OTUD7C | AAA51550.1 | Smp_scaff000132 | Smp_052350 | 0.31 | 0.48 | 0.31 | 243 | 1.1e-18 | C806142.1 | 0.3 | 0.46 | 0.26 | 92 | 4e-19 | Smp_scaff000132 | 1-352; 344-471; 470-666; 664-788; 787-1645; 1645-1717 | 86989-86638; 86051-85924; 82232-82038; 81090-80966; 78666-77808; 76290-76218 | 1695 | 0 | TRABID protein [Homo sapiens] | CAB64449.1 | 0.45 | 0.63 | 0.39 | 260 | 5e-68 | zinc finger, RAN-binding domain containing 1 [[NAME] rerio] | ref|NP_001071236.1 | 0.46 | 0.65 | 0.38 | 268 | 2e-70 | CD127364.1, CD116134.1, CD162909.1, CD162725.1, CD114590.1, CD160618.1, CD159162.1, CD158278.1, CD120463.1, CD114649.1, CD114841.1, CD120037.1, CD114708.1, CD091456.1, CD120236.1, [NAME], CD120007.1, AI976982.1, CD161040.1
c-IAP1/2 | Cellular inhibitor of apoptosis protein 1/2 (c-IAP1/2) | BIRC2, HIAP2, MIHB | NP_001157.1 | Smp_scaff000230 | Smp_159540 | 0.42 | 0.55 | 0.57 | 174 | 7.1e-09 | C804227.1 | 0.4 | 0.54 | 0.15 | 70 | 1e-12 | Smp_scaff000230 | 2-198; 197-449; 450-649; 650-699; 700-760 | 102003-102199; 102228-102480; 103441-103640; 104878-104927; 106451-106511 | 502 | e-140 | baculoviral IAP repeat-containing 6 [Homo sapiens] | [NAME] | 0.39 | 0.54 | 0.03 | 115 | 3e-24 | PREDICTED: baculoviral IAP repeat-containing 6 (apollon) [[NAME] caballus] | ref|XP_001918120.1 | 0.39 | 0.54 | 0.03 | 115 | 3e-24 | CD186694.1, CD157421.1
Caspase-3 | Cysteine caspase-3 (Caspase-3) | CPP32, APOPAIN, CASP3 | CAC88866 | Smp_scaff000059 | Smp_028500 | 0.43 | 0.61 | 0.82 | 505 | 1.1e-48 | C802352.1 | 0.43 | 0.61 | 0.82 | 200 | 2e-52 | Smp_scaff000059 | 1-66; 67-368; 367-545; 543-669; 677-1051 | 901670-901735; 905867-906168; 908802-908980; 913233-913359; 914118-914492 | 743 | 0 | Homo sapiens caspase 3, apoptosis-related cysteine protease | AAP36827.1 | 0.44 | 0.61 | 0.82 | 198 | 2e-49 | PREDICTED: caspase 3 [Taeniopygia guttata] | XP_002191294.1 | 0.41 | 0.55 | 0.98 | 201 | 4e-50 | AM045525.1, AM045911.1, CD078908.2, CD150426.1, CD150347.1, CD150445.1, CD097942.1, AI067589.1, CD188871.1, [NAME], [NAME], EX706197.1
Caspase-8 | Cysteine caspase-8 (Caspase-8) | MACH, CASP8, FLICE, [NAME] | BAB32555.1 | Smp_scaff000078 | Smp_141270 | 0.37 | 0.54 | 0.48 | 390 | 5e-36 | C915406.1 | 0.35 | 0.5 | 0.27 | 77 | 8e-15 | Smp_scaff000078 | 18-145; 146-204; 290-388; 386-663 | 1747431-1747304; 1746444-1746386; 1746070-1745972;1742569-1742292 | 545 | e-153 | caspase 2, apoptosis-related cysteine peptidase [Homo sapiens] | GENE ID: 835 [NAME] | 0.33 | 0.57 | 0.34 | 78.2 | 4e-13 | PREDICTED: caspase 8 [Taeniopygia guttata] | XP_002190143.1 | 0.4 | 0.57 | 0.27 | 100 | 9e-20 | CD082270.1