Spreadsheet: 7256ef30-7963-45d9-ad2b-770f0ee9e077
Sheet: Periodontitis unique genes

Uniquely expressed genes within enriched pathways in periodontitis-affected gingival tissues.
Neuroactive ligand-receptor [NAME]
C=256;O=19;E=2.52;R=7.53;rawP=1.46e-11;adjP=8.18e-10
[NAME] stable ID | Gene symbol | Description
ENSG00000135312 | HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B
ENSG00000126010 | GRPR | gastrin-releasing peptide receptor
ENSG00000112164 | GLP1R | glucagon-like peptide 1 receptor
[NAME] | NTSR1 | neurotensin receptor 1 (high affinity)
ENSG00000176884 | GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1
ENSG00000171596 | NMUR1 | neuromedin U receptor 1
ENSG00000166603 | MC4R | melanocortin 4 receptor
ENSG00000171189 | GRIK1 | glutamate receptor, ionotropic, kainate 1
ENSG00000145451 | GLRA3 | glycine receptor, alpha 3
ENSG00000179097 | [NAME] | 5-hydroxytryptamine (serotonin) receptor 1F
ENSG00000179603 | GRM8 | glutamate receptor, metabotropic 8
ENSG00000134489 | HRH4 | histamine receptor H4
ENSG00000183473 | SSTR3 | somatostatin receptor 3
ENSG00000113262 | GRM6 | glutamate receptor, metabotropic 6
ENSG00000182687 | GALR2 | galanin receptor 2
ENSG00000171873 | ADRA1D | adrenergic, alpha-1D-, receptor
ENSG00000104826 | LHB | luteinizing hormone beta polypeptide
ENSG00000123901 | GPR83 | G protein-coupled receptor 83
ENSG00000109158 | GABRA4 | gamma-aminobutyric acid (GABA) A receptor, alpha 4
Cytokine-cytokine receptor interaction----04060
C=267;O=18;E=2.63;R=6.84;rawP=2.41e-10;adjP=6.75e-09
ENSG00000108688 | CCL7 | chemokine (C-C motif) ligand 7
ENSG00000184451 | CCR10 | chemokine (C-C motif) receptor 10
ENSG00000167236 | CCL23 | chemokine (C-C motif) ligand 23
ENSG00000135409 | AMHR2 | anti-Mullerian hormone receptor, type II
ENSG00000115705 | TPO | thyroid peroxidase
ENSG00000164400 | [NAME] | colony stimulating factor 2 (granulocyte-macrophage)
ENSG00000117400 | MPL | myeloproliferative leukemia virus oncogene
ENSG00000128438 | TNFRSF13B | tumor necrosis factor receptor superfamily, member 13B
ENSG00000183625 | CCR3 | chemokine (C-C motif) receptor 3
ENSG00000111536 | IL26 | interleukin 26
ENSG00000186827 | TNFRSF4 | tumor necrosis factor receptor superfamily, member 4
ENSG00000164485 | IL22RA2 | interleukin 22 receptor, alpha 2
ENSG00000163737 | PF4 | platelet factor 4
[NAME] | IL17A | interleukin 17A
ENSG00000172156 | CCL11 | chemokine (C-C motif) ligand 11
ENSG00000162594 | [NAME] | interleukin 23 receptor
ENSG00000131142 | CCL25 | chemokine (C-C motif) ligand 25
ENSG00000163736 | PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Chemokine signaling pathway----04062
C=190;O=10;E=1.87;R=5.34;rawP=2.16e-05;adjP=0.0004
ENSG00000108688 | CCL7 | chemokine (C-C motif) ligand 7
ENSG00000184451 | CCR10 | chemokine (C-C motif) receptor 10
ENSG00000167236 | CCL23 | chemokine (C-C motif) ligand 23
ENSG00000183625 | CCR3 | chemokine (C-C motif) receptor 3
ENSG00000127588 | GNG13 | guanine nucleotide binding protein (G protein), gamma 13
ENSG00000163737 | PF4 | platelet factor 4
ENSG00000172156 | CCL11 | chemokine (C-C motif) ligand 11
ENSG00000114124 | GRK7 | G protein-coupled receptor kinase 7
ENSG00000163736 | PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
ENSG00000131142 | CCL25 | chemokine (C-C motif) ligand 25
Intestinal immune network for IgA production----04672
C=50;O=5;E=0.49;R=10.14;rawP=0.0001;adjP=0.0014
ENSG00000121594 | CD80 | CD80 molecule
ENSG00000184451 | CCR10 | chemokine (C-C motif) receptor 10
ENSG00000162896 | PIGR | [NAME] receptor
ENSG00000128438 | TNFRSF13B | tumor necrosis factor receptor superfamily, member 13B
ENSG00000131142 | CCL25 | chemokine (C-C motif) ligand 25
Alanine, aspartate and glutamate metabolism----00250
[NAME]
ENSG00000132744 | [NAME] | aspartoacylase (aminocyclase) 3
[NAME] | AGXT | alanine-glyoxylate aminotransferase
ENSG00000182890 | GLUD2 | glutamate dehydrogenase 2
ENSG00000203797 | DDO | D-aspartate oxidase
Tyrosine metabolism----00350
C=46;O=4;E=0.45;R=8.82;rawP=0.0011;adjP=0.0103
ENSG00000123454 | DBH | dopamine beta-hydroxylase (dopamine beta-monooxygenase)
ENSG00000158104 | HPD | 4-hydroxyphenylpyruvate dioxygenase
ENSG00000180176 | TH | [NAME]
ENSG00000115705 | TPO | thyroid peroxidase
Calcium signaling pathway----04020
C=178;O=7;E=1.75;R=3.99;rawP=0.0020;adjP=0.0160
ENSG00000175344 | CHRNA7 | [NAME], nicotinic, alpha 7
ENSG00000102001 | CACNA1F | calcium channel, voltage-dependent, L type, alpha 1F subunit
ENSG00000126583 | PRKCG | protein kinase C, gamma
ENSG00000126010 | GRPR | gastrin-releasing peptide receptor
ENSG00000171873 | ADRA1D | adrenergic, alpha-1D-, receptor
[NAME] | NTSR1 | neurotensin receptor 1 (high affinity)
ENSG00000176884 | GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1
Hedgehog signaling pathway----04340
C=56;O=4;E=0.55;R=7.24;rawP=0.0023;adjP=0.0161
ENSG00000125084 | WNT1 | wingless-type MMTV integration site family, member 1
ENSG00000183682 | BMP8A | bone morphogenetic protein 8a
ENSG00000115596 | WNT6 | wingless-type MMTV integration site family, member 6
ENSG00000158955 | WNT9B | wingless-type MMTV integration site family, member 9B
Systemic lupus erythematosus----05322
C=140;O=6;E=1.38;R=4.35;rawP=0.0027;adjP=0.0168
ENSG00000176919 | [NAME] | complement component 8, gamma polypeptide
ENSG00000197697 | HIST1H2BE | histone cluster 1, H2be
ENSG00000121594 | CD80 | CD80 molecule
ENSG00000196966 | [NAME] | histone cluster 1, H3e
ENSG00000077522 | ACTN2 | actinin, alpha 2
ENSG00000233822 | HIST1H2BN | histone cluster 1, H2bn
Glycine, serine and threonine metabolism----00260
C=31;O=3;E=0.31;R=9.82;rawP=0.0035;adjP=0.0196
ENSG00000132837 | [NAME] | dimethylglycine dehydrogenase
ENSG00000145692 | BHMT | [NAME] methyltransferase
[NAME] | AGXT | alanine-glyoxylate aminotransferase
Jak-STAT signaling pathway----04630
C=155;O=6;E=1.53;R=3.93;rawP=0.0045;adjP=0.0229
ENSG00000115705 | TPO | thyroid peroxidase
ENSG00000164485 | IL22RA2 | interleukin 22 receptor, alpha 2
ENSG00000164400 | [NAME] | colony stimulating factor 2 (granulocyte-macrophage)
ENSG00000117400 | MPL | myeloproliferative leukemia virus oncogene
ENSG00000162594 | [NAME] | interleukin 23 receptor
ENSG00000111536 | IL26 | interleukin 26
Vascular smooth muscle contraction----04270
C=115;O=5;E=1.13;R=4.41;rawP=0.0058;adjP=0.0271
ENSG00000102001 | CACNA1F | calcium channel, voltage-dependent, L type, alpha 1F subunit
ENSG00000187048 | CYP4A11 | cytochrome P450, family 4, subfamily A, polypeptide 11
ENSG00000126583 | PRKCG | protein kinase C, gamma
ENSG00000171873 | ADRA1D | adrenergic, alpha-1D-, receptor
ENSG00000162365 | CYP4A22 | cytochrome P450, family 4, subfamily A, polypeptide 22
Arrhythmogenic right ventricular cardiomyopathy (ARVC)----05412
C=76;O=4;E=0.75;R=5.34;rawP=0.0068;adjP=0.0293
ENSG00000102001 | CACNA1F | calcium channel, voltage-dependent, L type, alpha 1F subunit
ENSG00000077522 | ACTN2 | actinin, alpha 2
ENSG00000066032 | CTNNA2 | catenin (cadherin-associated protein), alpha 2
ENSG00000130433 | CACNG6 | calcium channel, voltage-dependent, gamma subunit 6