Spreadsheet: b9ff0b8b-892d-44bc-a20c-822372eb7435
Sheet: Sheet1

Table A – Metabolism. Gain/Loss in C. elegans | Unnamed: 1 | Unnamed: 2 | Unnamed: 3
EC number | Species Distribution | Enzyme name | KEGG pathway annotation
1.1.1.10 | ASP | L-xylulose reductase | ko00040 (Pentose and glucuronate interconversions)
1.1.1.127 | XIP | 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase | ko00040 (Pentose and glucuronate interconversions)
1.1.1.146 | PVP | 11b-hydroxysteroid dehydrogenase | [NAME] (C21-Steroid hormone metabolism), ko00150 (Androgen and estrogen metabolism)
1.1.1.153 | BMP,NBP,TSP,XIP | sepiapterin reductase | ko00790 (Folate biosynthesis)
1.1.1.154 | GPP,HGP,MIP | ureidoglycolate dehydrogenase | [NAME] (Purine metabolism)
1.1.1.18 | HGP | inositol 2-dehydrogenase | [NAME] (Inositol metabolism), ko00562 (Inositol phosphate metabolism)
1.1.1.30 | ASP,GRP,HGP,MIP,OOP,OVP | 3-hydroxybutyrate dehydrogenase | [NAME] (Butanoate metabolism),ko00072
1.1.1.5 | PPP | acetoin dehydrogenase | [NAME] (Butanoate metabolism)
1.1.1.51 | ASP,HCP | 17-ketoreductase | ko00150 (Androgen and estrogen metabolism)
1.1.1.62 | ASP,HCP | [NAME] | ko00150 (Androgen and estrogen metabolism)
1.1.1.78 | MIP | [NAME] | ko00620 (Pyruvate metabolism)
1.1.1.79 | MIP | NADPH-glyoxylate reductase | ko00620 (Pyruvate metabolism)
1.1.2.3 | TDP | L-lactate dehydrogenase (cytochrome) | ko00620 (Pyruvate metabolism)
1.1.3.8 | XIP | L-gulonolactone oxidase | ko00053 (Ascorbate and aldarate metabolism)
1.1.4.1 | HCP | vitamin-K-epoxide reductase (warfarin-sensitive) | ko00100 (Biosynthesis of steroids)
1.1.99.- | XIP | metabolism of secondary metabolism
1.13.11.52 | HCP,OOP,OVP | indoleamine 2,3-dioxygenase | ko00380 (Tryptophan metabolism)
1.14.11.23 | XIP | flavonol synthase | ko00941 (Flavonoid biosynthesis)
1.14.13.30 | MIP | [NAME] 20-monooxygenase | [NAME] (Arachidonic acid metabolism)
1.14.15.3 | MIP | alkane 1-monooxygenase | [NAME] (Fatty acid metabolism)
1.2.1.16 | SSP | succinate-semialdehyde dehydrogenase | ko00251 (Glutamate metabolism), ko00350 (Tyrosine metabolism), [NAME] (Butanoate metabolism)
1.2.1.2 | ZPP | formate dehydrogenase | ko00630 (Glyoxylate and dicarboxylate metabolism), [NAME] (Methane metabolism)
1.2.1.36 | GPP,TCP | cytosolic retinal dehydrogenase | ko00830 ([NAME] metabolism)
1.2.1.51 | BMP | pyruvate dehydrogenase (NADP+) | ko00010 (Glycolysis / Gluconeogenesis), [NAME] (Alanine and aspartate metabolism), ko00620 (Pyruvate metabolism)
1.2.1.8 | ACP,AYP,HCP,HGP,MAP,MIP,SRP,SSP | betaine-aldehyde dehydrogenase | ko00260 (Pyruvate metabolism)
1.2.4.1 | BMP | pyruvate dehydrogenase | ko00010, ko00252 (Alanine and aspartate metabolism), [NAME] ([NAME], leucine and isoleucine biosynthesis),ko00620 (Pyruvate metabolism), [NAME] (Butanoate metabolism)
1.2.4.4 | MHP,PTP | 3-methyl-2-oxobutanoate dehydrogenase | ko00280 (methylglutaconyl-CoA hydratase)
1.3.1.3 | ALP,RSP,SSP,XIP,ZPP | delta4-3-oxosteroid 5beta-reductase | ko00120 (Bile acid biosynthesis), [NAME] (C21-Steroid hormone metabolism)
1.3.1.33 | ACP,HGP | NADPH2-protochlorophyllide oxidoreductase | ko00860 (Porphyrin and chlorophyll metabolism)
1.3.99.6 | ALP,RSP,SSP,XIP,ZPP | 3-oxo-5beta-steroid 4-dehydrogenase | ko00120 (Bile acid biosynthesis), [NAME] (C21-Steroid hormone metabolism), ko00150 (Androgen and estrogen metabolism)
1.7.1.10 | OVP | hydroxylamine reductase | ko00910 (Nitrogen metabolism)
1.8.98.1 | OVP | heterodisulfide reductase | ko00790 (Folate biosynthesis)
2.2.1.- | MCP | Methyltransferases
2.1.1.14 | GPP,HGP,HSP,XIP | 5-methyltetrahydropteroyltriglutamate-homocysteine | ko00271 ([NAME] metabolism)
2.1.1.37 | OOP,PPP,TDP,XIP | DNA (cytosine-5-)-methyltransferase | ko00271 ([NAME] metabolism)
2.1.1.5 | XIP | [NAME] S-methyltransferase. ko00260 (Glycine, serine and threonine metabolism), ko00271 ([NAME] metabolism)
2.1.2.11 | PVP | 3-methyl-2-oxobutanoate hydroxymethyltransferase. ko0770 (Pantothenate and CoA biosynthesis)
2.2.1.7 | OVP | 1-deoxy-D-xylulose-5-phosphate synthase | ko00100 (Biosynthesis of steroids)
2.3.1.41 | NBP | beta-ketoacyl-acyl-carrier-protein synthase I | ko00061 (Fatty acid biosynthesis)
2.3.1.54 | BMP,WBP | formate C-acetyltransferase | ko00620 (Pyruvate metabolism), [NAME] (Propanoate metabolism), [NAME] (Butanoate metabolism)
2.3.3.13 | WBP | glycine N-acyltransferase
2.4.1.- | DIP,HGP | Glycosyltransferases
2.4.1.133 | XIP | [NAME] | ko00532 (Chondroitin sulfate biosynthesis)
2.4.1.228 | XIP | scopoletin glucosyltransferase | [NAME] (Stilbene, coumarine and lignin biosynthesis)
2.4.1.62 | OVP | UDP-galactose-G(M2) galactosyltransferase | [NAME] (Glycosphingolipid biosynthesis - ganglioseries), [NAME] (Glycan structures - biosynthesis 2)
2.4.1.64 | OVP | alpha,alpha-trehalose phosphorylase | ko00500 (Starch and sucrose metabolism)
2.4.1.69 | DIP | galactoside 2-alpha-L-fucosyltransferase | [NAME] (Glycosphingolipid biosynthesis - lactoseries), [NAME] (Glycosphingolipid biosynthesis - neo-lactoseries), ko00603 (Glycosphingolipid biosynthesis - globoseries), [NAME] (Glycan structures - biosynthesis 2)
2.4.1.79 | ASP,MAP | globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase | ko00603 (Glycosphingolipid biosynthesis - globoseries), [NAME] (Glycan structures - biosynthesis 2)
2.4.1.86 | MIP | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase
2.4.99.9 | BMP | lactosylceramide alpha-2,3-sialyltransferase | [NAME] (Glycosphingolipid biosynthesis - ganglioseries), [NAME] (Glycan structures - biosynthesis 2)
2.5.1.- | OVP | Transferring alkyl or [NAME]
2.5.1.29 | AYP,DIP,NAP,OVP,PPP | farnesyltranstransferase | ko00100 (Biosynthesis of steroids), [NAME] (Terpenoid biosynthesis)
2.5.1.3 | HGP | thiamine-phosphate diphosphorylase | [NAME] (Thiamine metabolism)
2.5.1.54 | OVP | 3-deoxy-7-phosphoheptulonate synthase | ko00400 (Phenylalanine, tyrosine and tryptophan biosynthesis)
2.6.1.11 | XIP | trans-octaprenyltranstransferase | ko00100 (Biosynthesis of steroids)
2.6.1.39 | XIP | 4-hydroxybenzoate nonaprenyltransferase | ko00130 (Ubiquinone biosynthesis)
2.6.1.62 | BMP | chlorophyll synthase | ko00860 (Porphyrin and chlorophyll metabolism)
2.7.1.153 | XIP | phosphatidylinositol-4,5-bisphosphate 3-kinase | 21 pathways
2.7.1.3 | ASP | ketohexokinase | ko00051 (Fructose and mannose metabolism)
2.7.1.32 | ASP,MIP,MJP,OOP,SRP | [NAME] | ko00260 (Glycine, serine and threonine metabolism), ko00564 (Glycerophospholipid metabolism)
2.7.1.73 | BMP | inosine kinaseko00230 (Purine metabolism)
2.7.6.3 | OVP | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | ko00790 (Folate biosynthesis)
2.7.7.30 | XIP | fucose-1-phosphate guanylyltransferase | ko00051 (Fructose and mannose metabolism)
2.7.7.4 | PTP | sulfate adenylyltransferase. [NAME] (Purine metabolism), [NAME] (Selenoamino acid metabolism), [NAME] (Sulfur metabolism)
2.8.1.2 | PPP,TVP,XIP | 3-mercaptopyruvate sulfurtransferase | [NAME] (Cysteine metabolism)
2.8.1.6 | HGP | leucine transaminase. ko00280 ([NAME], leucine and isoleucine degradation), [NAME] ([NAME], leucine and isoleucine biosynthesis), ko00770 (Pantothenate and CoA biosynthesis)
2.8.2.2 | PTP | alcohol sulfotransferase ko00150 (Androgen and estrogen metabolism) & ko00290 (Sulfur metabolism)
3.1.1.11 | MIP,OVP | pectinesterase | ko00040 (Pentose and glucuronate interconversions), [NAME] (Starch and sucrose metabolism)
3.1.1.23 | OVP | acylglycerol lipase | ko00561 (Glycerolipid metabolism)
3.1.1.78 | MIP | polyneuridine-aldehyde esterase | [NAME] (Indole and ipecac alkaloid biosynthesis)
3.1.3.1 | XIP | alkaline phosphatase | ko00361 (gamma-Hexachlorocyclohexane degradation), [NAME] (Folate biosynthesis), ko02020 (Two-component system - General)
3.1.3.12 | TSP | trehalose-phosphatase | ko00500 (Starch and sucrose metabolism)
3.1.3.9 | TMP,XIP | glucose-6-phosphatase | ko00010 (Glycolysis / Gluconeogenesis), [NAME] (Galactose metabolism), [NAME] (Starch and sucrose metabolism), [NAME] (Insulin signaling pathway), [NAME] (Adipocytokine signaling pathway)
3.1.5.1 | WBP | dGTPase | [NAME] (Purine metabolism)
3.2.1.10 | ACP,ASP,OOP,PTP,WBP | oligo-1,6-glucosidase | ko00500 (Starch and sucrose metabolism)
3.2.1.15 | MHP,MJP | polygalacturonase | ko00040 (Pentose and glucuronate interconversions), [NAME] (Starch and sucrose metabolism)
3.2.1.2 | HGP | beta-amylase | ko00500 (Starch and sucrose metabolism)
3.2.1.4 | GPP,GRP,HGP,HSP,MAP,MCP,MHP,[NAME],MJP,PVP | cellulase. ko00500 (Starch and sucrose metabolism)
3.2.1.49 | BMP,MAP,MHP,MIP,OVP,PEP,XIP | alpha-N-acetylgalactosaminidase. ko00603 (Glycosphingolipid biosynthesis - globoseries)
3.2.1.84 | XIP | [NAME]-glucosidase | ko00510 (N-Glycan biosynthesis), [NAME] (Glycan structures - biosynthesis 1)
3.2.1.93 | ASP,DIP | alpha,alpha-phosphotrehalase | ko00500 (Starch and sucrose metabolism)
3.4.11.5 | TVP | prolyl aminopeptidase | ko00330 (Arginine and proline metabolism)
3.4.19.9 | TVP | gamma-glutamyl hydrolase | ko00790 (Folate biosynthesis)
3.5.1.- | SRP | Hydrolases
3.5.1.1 | OOP | asparaginase | ko00252 (Alanine and aspartate metabolism), ko00460 (Cyanoamino acid metabolism), [NAME] (Nitrogen metabolism)
3.5.1.18 | HCP | succinyl-diaminopimelate desuccinylase | [NAME] (Lysine biosynthesis)
3.5.2.3 | AYP | dihydroorotase | ko00240 (Pyrimidine metabolism)
3.6.1.17 | MCP | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) | [NAME] (Purine metabolism), [NAME] (Pyrimidine metabolism)
3.6.1.29 | BMP,MHP,OVP | bis(5'-adenosyl)-triphosphatase | [NAME] (Purine metabolism)
3.6.1.5 | OOP | ATP-diphosphatase | [NAME] (Purine metabolism), [NAME] (Pyrimidine metabolism)
3.6.1.7 | XIP | acetylphosphatase | ko00010 (Glycolysis / Gluconeogenesis), ko00620 (Pyruvate metabolism), [NAME] (Benzoate degradation via CoA ligation)
3.8.1.5 | SSP | [NAME] | ko00361 (gamma-Hexachlorocyclohexane degradation), ko00631 (1,2-Dichloroethane degradation), [NAME] (3-Chloroacrylic acid degradation)
4.1.1.31 | BMP | phosphoenolpyruvate carboxylase | ko00620 (Pyruvate metabolism), [NAME] (Carbon fixation), ko00720 (Reductive carboxylate cycle)
4.1.1.37 | MPP | uroporphyrinogen decarboxylase | ko00860 (Porphyrin and chlorophyll metabolism)
4.1.1.39 | TSP | ribulose-bisphosphate carboxylase | ko00630 (Glyoxylate and dicarboxylate metabolism), [NAME] (Carbon fixation)
4.1.1.68 | GRP | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase | ko00350 (Tyrosine metabolism)
4.1.3.3 | XIP | N-acetylneuraminate lyase | ko00530 (Aminosugars metabolism)
4.1.3.36 | XIP | naphthoate synthase | ko00130 (Ubiquinone biosynthesis)
4.2.1.104 | BMP,GRP,SRP | cyanate hydratase | ko00910 (Nitrogen metabolism)
4.2.1.18 | ASP,PPP | methylglutaconyl-CoA hydratase | ko00280 (methylglutaconyl-CoA hydratase)
4.2.1.42 | OVP | galactarate dehydratase | ko00053 (Ascorbate and aldarate metabolism)
4.2.1.52 | XIP | dihydrodipicolinate synthase | [NAME] (Lysine biosynthesis)
4.2.1.6 | LSP | galactonate dehydratase. | [NAME] (Galactose metabolism)
5.1.3.4 | PVP,XIP | L-ribulose-5-phosphate 4-epimerase | ko00040 (Pentose and glucuronate interconversions), ko00053 (Ascorbate and aldarate metabolism)
5.3.3.10 | ACP,LSP | 5-carboxymethyl-2-hydroxymuconate delta-isomerase | ko00350 (Tyrosine metabolism), ko00362 (Benzoate degradation via hydroxylation)
5.4.2.6 | ASP,SRP | beta-phosphoglucomutase | ko00500 (Starch and sucrose metabolism)
5.4.99.5 | GPP,MAP,MHP | chorismate mutase | ko00400 (Phenylalanine, tyrosine and tryptophan biosynthesis)
5.5.1.1 | ACP | muconate cycloisomerase | ko00362 (Benzoate degradation via hydroxylation), [NAME] (Toluene and xylene degradation), [NAME] (1,4-Dichlorobenzene degradation)
6.2.1.1 | AYP | acetate-CoA ligase | ko00010 (Glycolysis / Gluconeogenesis), ko00620 (Pyruvate metabolism), [NAME] (Propanoate metabolism), ko00720 (Reductive carboxylate cycle (CO2 fixation))
6.3.2.1 | HGP | pantoate-beta-alanine ligase | ko00410 (beta-Alanine metabolism), ko00770 (Pantothenate and CoA biosynthesis)
6.3.4.6 | XIP | urea carboxylase | [NAME] (Urea cycle and metabolism of amino groups)