Spreadsheet: b8250179-4bf3-4f7c-b162-eed3ec307fd5
Sheet: Sheet1

Table S4A: Functional analysis of genes significantly increased in AA vs. CA | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7
[NAME] | [NAME] | Representative  ID | [NAME] | FC | P-value | CL | UniGene ID
 |  |  | Signal Tranduction
8781 | PSPH | NM_004577 | phosphoserine phosphatase | 2.69557998383673 | 9.36730763730797e-06 | 7q11.2 | Hs.536913
9659 | PDE4DIP | AB042557 | phosphodiesterase 4D interacting protein | 2.49929228837078 | 5.36572489992318e-06 | 1q12 | Hs.584841
8490 | RGS5 | NM_003617 | regulator of G-protein signalling 5 | 2.34710127603253 | 0.000688350941076208 | 1q23.1 | Hs.24950
6654 | SOS1 | L13857 | son of sevenless homolog 1 | 1.66994934892401 | 9.05911607635266e-05 | [NAME] | Hs.654397
5865 | RAB3B | NM_002867 | Member [NAME] oncogene family | 1.63848375935795 | 0.000553444774770972 | 1p32-p31 | Hs.123072
9289 | GPR56 | NM_005682 | G protein-coupled receptor 56 | 1.6153602385582 | 0.00514292964358026 | 16q12.2-q21 | Hs.513633
8605 | PLA2G4C | NM_003706 | phospholipase A2, group IVC | 1.60495885325876 | 0.00155849561398769 | 19q13.3 | Hs.631562
4660 | PPP1R12B | AF324888 | protein phosphatase 1, regulatory (inhibitor) subunit 12B | 1.53402129705047 | 0.0026117047178469 | 1q32.1 | Hs.444403
4638 | MYLK | NM_005965 | [NAME], light polypeptide kinase | 1.47201052257983 | 0.0435353481705864 | 3q21 | Hs.556600
116987 | CENTG2 | NM_014914 | centaurin, gamma 2 | 1.35044241504909 | 0.0103404364727078 | 2p24.3-p24.1 | Hs.435039
4883 | [NAME] | NM_000908 | natriuretic peptide receptor C | 1.34510450439215 | 0.0403787393299833 | 5p14-p13 | [NAME]
85360 | SYDE1 | AK023573 | synapse defective 1, Rho GTPase, homolog 1 | 1.33548969171209 | 0.00115129543180062 | 19p13.12 | Hs.528701
5747 | PTK2 | AL037339 | [NAME] 2 | 1.33469260275843 | 0.0392651151887564 | 8q24-qter | Hs.395482
109 | ADCY3 | AF033861 | adenylate cyclase 3 | 1.2965 | 0.03003 | 2p23.3 | Hs.467898
115 | ADCY9 | AF036927 | adenylate cyclase 9 | 1.21 | 0.021551669 | 16p13.3 | Hs.391860;Hs.610484
 |  |  | Cellular detoxification/oxidative stress
2953 | GSTT2 | NM_000854 | glutathione S-transferase theta 2 | 2.81696354446418 | 2.24861474729475e-09 | 22q11.2; 22q11.23 | Hs.654462
91227 | GGT1 | L20493 | gamma-glutamyltransferase 1 | 1.62334175775602 | 0.000428703229455837 | 22q11.22 | Hs.450000
645367 | [NAME] | AI344075 | gamma-glutamyltransferase 2 | 1.5369111432357 | 0.00187488208393808 | 22q11.1 | Hs.650223
92086 | GGTLA4 | L20492 | gamma-glutamyltransferase-like activity 4 | 1.44325986848509 | 0.00906054425972356 | 20p11.1 | Hs.355394
2948 | GSTM4 | NM_000850 | glutathione S-transferase M4 | 1.42257173060244 | 0.0244622658270746 | 1p13.3 | Hs.348387
2944 | GSTM1 | NM_000561 | glutathione S-transferase M1 | 1.37583370821195 | 0.000991576399450497 | 1p13.3 | Hs.301961
2947 | GSTM3 | AL527430 | glutathione S-transferase M3 | 1.3136045555903 | 0.0145307128398587 | 1p13.3 | Hs.2006
2946 | GSTM2 | NM_000848 | glutathione S-transferase M2 | 1.30231870191997 | 0.00208932724057648 | 1p13.3 | Hs.279837
 |  |  | Growth factors and receptors
3486 | IGFBP3 | BF340228 | insulin-like growth factor binding protein 3 | 1.73717576871674 | 0.0488285943575233 | 7p13-p12 | Hs.450230
2254 | FGF9 | NM_002010 | fibroblast growth factor 9 (glia-activating factor) | 1.5106884586433 | 0.0268200941866985 | 13q11-q12 | Hs.111
2674 | [NAME] | NM_005264 | GDNF family receptor alpha 1 | 1.49035671182549 | 0.00602716399949585 | 10q26 | Hs.591913
6376 | CX3CL1 | U84487 | chemokine (C-X3-C motif) ligand 1 | 1.47856591599161 | 0.0497987775769029 | 16q13 | Hs.531668
3488 | IGFBP5 | R73554 | insulin-like growth factor binding protein 5 | 1.46267150936522 | 0.0113223203287093 | 2q33-q36 | Hs.635441
 |  |  | RNA binding and processing
10521 | DDX17 | U59321 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | 2.4391975614956 | 0.000124460695619647 | 22q13.1 | Hs.528305
26777 | SNORA71A | AA827892 | U71A small nucleolar RNA | 1.54463562772863 | 0.00144252088511112 | 20q11.23 | Hs.681779
1984 | EIF5A | AA393940 | Eukaryotic translation initiation factor 5A | 1.48546023965401 | 0.0182584050222413 | 17p13-p12 | Hs.534314
54913 | RPP25 | NM_017793 | ribonuclease P 25kDa subunit | 1.40305252956261 | 0.00345174337566082 | 15q24.1 | Hs.8562
7536 | SF1 | D26121 | splicing factor 1 | 1.36788700806727 | 0.0172204381291986 | 11q13 | [NAME]
 |  |  | Transcription factor activity
4487 | MSX1 | NM_002448 | [NAME] homolog 1 (Drosophila) | 2.01029145013067 | 0.000403565889818202 | 4p16.3-p16.1 | Hs.424414
678 | ZFP36L2 | AI356398 | zinc finger protein 36, C3H type-like 2 | 1.7201408440984 | 0.00691957137713711 | 2p22.3-p21 | Hs.503093
338645 | LUZP2 | X81895 | [NAME] protein 2 | 1.65323823519772 | 0.00679792617139519 | 11p14.3 | Hs.144138
4781 | NFIB | U70862 | nuclear factor I/B | 1.53745452439789 | 0.0265319689942131 | 9p24.1 | Hs.699215
23493 | HEY2 | NM_012259 | hairy/enhancer-of-split | 1.50925194304238 | 0.0117337827178854 | 6q21 | Hs.144287
6936 | C2orf3 | AC005034 | chromosome 2 open reading frame 3 | 1.48478936723984 | 0.00301651204151813 | 2p11.2-p11.1 | Hs.44024
165 | AEBP1 | NM_001129 | AE binding protein 1 | 1.47826998053343 | 0.0251921252794303 | [NAME] | Hs.439463
862 | RUNX1T1 | X79990 | runt-related transcription factor 1 | 1.45287344650431 | 0.0391846369745642 | 8q22 | Hs.368431
 |  |  | Cell Adhesion
8839 | WISP2 | NM_003881 | WNT1 inducible signaling pathway protein 2 | 1.99677980959327 | 7.47754747298416e-05 | 20q12-q13.1 | Hs.592145
1948 | EFNB2 | U16797 | ephrin-B2 | 1.954048213848 | 0.00378481062258829 | 13q33 | Hs.149239
22871 | NLGN1 | NM_014932 | neuroligin 1 | 1.73131894290801 | 0.00445739035317741 | 3q26.31 | Hs.478289
23136 | EPB41L3 | NM_012307 | erythrocyte membrane protein band 4.1-like 3 | 1.65842306416836 | 0.00198619437662733 | 18p11.32 | Hs.213394
 |  |  | Cytoskeleton, chaperones
1415 | CRYBB2 | NM_000496 | crystallin, beta B2 | 2.182594650146 | 1.80802936460419e-06 | 22q11.2-q12.1; 22q11.23 | [NAME]
6442 | SGCA | L35853 | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) | 1.84038252783725 | 4.00699286758854e-06 | 17q21 | Hs.463412
3306 | HSPA2 | U56725 | heat shock 70kDa protein 2 | 1.77569262669937 | 0.00050791607501012 | 14q24.1 | Hs.432648
126393 | HSPB6 | AL551046 | heat shock protein, alpha-crystallin-related, [NAME] | 1.50240082770642 | 0.0193442776914224 | 19q13.12 | Hs.534538
4638 | MYLK | NM_005965 | [NAME], light polypeptide kinase | 1.47201052257983 | 0.0435353481705864 | 3q21 | Hs.556600
64780 | MICAL1 | NM_022765 | microtubule associated monoxygenase, calponin and LIM domain containing 1 | 1.46333785210197 | 0.00790326360648947 | 6q21 | Hs.33476
9638 | FEZ1 | NM_005103 | fasciculation and elongation protein zeta 1 (zygin I) | 1.40931481729962 | 0.0231943289539377 | 11q24.2 | Hs.224008
 |  |  | Immune response
64167 | LRAP | NM_022350 | leukocyte-derived arginine aminopeptidase | 1.9720566466785 | 0.0165605391034277 | 5q15 | Hs.591249
9760 | TOX | AI961231 | [NAME] group box protein TOX | 1.92282715332523 | 0.00236880373837859 | 8q12.1 | Hs.491805
5698 | PSMB9 | NM_002800 | proteasome (prosome, macropain) subunit, beta type, 9 | 1.54334779312212 | 0.0053088422860872 | 6p21.3 | Hs.654585
683 | BST1 | NM_004334 | bone marrow stromal cell antigen 1 | 1.4094367402121 | 0.000719998054655199 | 4p15 | Hs.169998
3600 | IL15 | NM_000585 | interleukin 15 | 1.37624712008161 | 0.0344758380556386 | 4q31 | Hs.654378
3106 | HLA-B | D83043 | major histocompatibility complex, class I, B | 1.33872560295701 | 0.00871416378792007 | 6p21.3 | Hs.77961
3134 | HLA-F | NM_018950 | major histocompatibility complex, class I, F | 1.3379005253513 | 0.00189928166661464 | 6p21.3 | Hs.519972
 |  |  | Mitochondrial proteins
4835 | NQO2 | NM_000904 | NAD(P)H dehydrogenase, quinone 2 | 1.53517011590745 | 0.00173535883265012 | 6pter-q12 | Hs.533050
641371 | ACOT2 | NM_006821 | acyl-CoA thioesterase 2 | 1.42649295533729 | 0.00150388964438741 | 14q24.3 | Hs.700643
57509 | MTUS1 | AL096842 | mitochondrial tumor suppressor 1 | 1.41858143731648 | 0.0364789616419198 | 8p22 | Hs.7946
 |  |  | ECM and related protein
2006 | ELN | AA479278 | [NAME] | 2.20230720067343 | 0.00229676373269863 | 7q11.23 | Hs.647061
80781 | COL18A1 | AF018081 | collagen type XVIII, alpha 1 | 1.41 | 0.0169 | 21q22.3 | Hs. 84190
4052 | LTBP1 | NM_206943 | latent transforming growth factor beta binding protein 1 | 1.539 | 0.0239 | [NAME] | Hs.654497
 |  |  | One-Carbon metabolism
771 | CA12 | NM_001218 | carbonic anhydrase XII | 1.75609840606248 | 0.00745775316299348 | 15q22 | Hs.210995
 |  |  | Transport/carrier
3776 | KCNK2 | AF004711 | potassium channel, subfamily K, member 2 | 1.49079935026838 | 0.0371068067167388 | 1q41 | Hs.497745
80303 | EFHD1 | BC002449 | EF-hand domain family, member D1 | 1.49048565121288 | 0.0138508668495921 | 2q37.1 | Hs.516769
55089 | SLC38A4 | NM_018018 | solute carrier family 38, member 4 | 1.41179830565448 | 0.0176020506526081 | 12q13 | Hs.446077
785 | CACNB4 | NM_000726 | calcium channel, voltage-dependent, beta 4 subunit | 1.37756045346882 | 0.00638500203790597 | 2q22-q23 | Hs.614033
6509 | SLC1A4 | BF340083 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 1.32805630809815 | 0.0104631903216459 | 2p15-p13 | Hs.654352
 |  |  | Cell motility
267 | AMFR | NM_001144 | autocrine motility factor receptor | 2.79160151729618 | 3.75299678767806e-07 | 16q21 | Hs.295137
 |  |  | Protein degradation
4281 | MID1 | NM_000381 | midline 1 (ubiquitin ligase ) | 1.6475008834715 | 0.0384891385123997 | Xp22 | Hs.27695
5698 | PSMB9 | NM_002800 | proteasome (prosome, macropain) subunit, beta type 9 | 1.54334779312212 | 0.0053088422860872 | 6p21.3 | Hs.654585
1066 | [NAME] | S73751 | carboxylesterase 1 | 1.74975168095813 | 0.0105659656037585 | 16q13-q22.1 | Hs.558865
 |  |  | Others
83716 | CRISPLD2 | AL136861 | cysteine-rich secretory protein LCCL domain containing 2 | 1.51140628216141 | 0.0389110786735723 | 16q24.1 | Hs.513779
100 | ADA | [NAME] | adenosine deaminase | 1.54680699482203 | 0.0297125900125428 | 20q12-q13.11 | Hs.654536
FC: fold change; CL: chromosome location.