Spreadsheet: 893928e3-d48d-431d-b8e1-5cdebf26d576
Sheet: Sheet1

Table S7 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4
[NAME] (CF) responsive genes as identified by microarray analysis.
The genes shown here were significantly regulated  (>2 fold, p-value < 0.05) in WT-CF-treated cells and combined with genes that were significantly regulated (>2 fold, p-value < 0.05) in age3-CF-treated cells. This list was also used to illustrate the Cluster tree and [NAME] diagram in Figure S3B.
CF responsive genes are color coded:
Red indicates transcript levels > 4.0; orange indicates transcript levels < 4.0 and > 2;
Dark green indicates transcript levels < 0.5 and > 0.3; pale green indicates transcript levels < 0.3.
WT+CF vs WT | age3+CF vs age3 | common name | systematic name | description
30.348763 | 8.124127 | [NAME] | orf19.4082 | Immunogenic stress-associated protein; regulated by filamentous growth pathways; induced by benomyl, caspofungin, or in azole-resistant strain; [NAME], farnesol, alkaline downregulated; similar to S. cerevisiae Ddr48p
17.430733 | 7.6696815 | RTA2 | orf19.24 | Putative floppase; required for sphingolipid long chain base release; mediates calcineurin-dependent resistance to azoles; stress-associated protein; Ca2+, calcineurin-regulated; ketoconazole, [NAME] induced; Plc1p-regulated
16.55034 | 5.038468 | SOD5 | [NAME] | [NAME] and zinc-containing superoxide dismutase; protective role against oxidative stress; induced by neutrophil contact, hyphal growth, caspofungin, osmotic or oxidative stress; member of a gene family including SOD1, SOD4, SOD5, and SOD6
15.317691 | 5.5616984 |  | orf19.2125 | Predicted ORF in Assemblies 19, 20 and 21
12.222304 | 8.800638000000003 |  | orf19.1765 | Predicted ORF in Assemblies 19, 20 and 21
11.518946 | 10.903233 |  | orf19.5313 | Predicted ORF from Assembly 19; merged with orf19.1430 in Assembly 20
10.548088 | 7.843598 | CRZ2 | orf19.2356 | Putative transcription factor; zinc finger; similar to S. cerevisiae Crz1p; homozygous crz1, not crz2, null mutation suppresses fluconazole resistance of homozygous cka2 null (defective in CK2 kinase ); Rim101p-downregulated at pH 8
10.364206 | 21.592148 |  | orf19.4706 | Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type; fluconazole-induced; transcription is induced in response to alpha pheromone in SpiderM medium
9.906688 | 7.2683206 |  | orf19.675 | Similar to cell wall proteins; induced in core stress response, core caspofungin response; iron-regulated; amphotericin B induced; regulated by Cyr1p, Ssn6p; possibly spurious ORF (Annotation Working Group prediction)
8.613029 | 5.0458674 | [NAME] | orf19.6595 | Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Yor049cp, which is involved in fatty acid transport; transposon mutation affects filamentous growth; alkaline downregulated; caspofungin induced
8.516965 | 6.083935 | CHS2 | orf19.7298 | Chitin synthase; nonessential; required for wild-type chitin deposition in hyphae; transcription is regulated during dimorphic transition; Chs1p and Chs2p, but not Chs3p, are inhibited by the protoberberine HWY-289; fungal-specific
7.282239 | 6.376933 |  | orf19.1473 | Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
7.178476 | 10.226856 | PGA23 | orf19.3740 | Putative GPI-anchored protein of unknown function; transcription is negatively regulated by Rim101p; regulated by Cyr1p; shows colony morphology-related gene regulation by Ssn6p
6.5622416 | 6.240636 |  | orf19.6840 | Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
6.555136 | 9.111152 | ASR1 | orf19.2344 | Protein described as similar to heat shock proteins; transcription regulated by cAMP, osmotic stress, ciclopirox olamine, ketoconazole; negatively regulated by Cyr1p, Ras1p; shows colony morphology-related gene regulation by Ssn6p
6.4996886 | 3.8710246 |  | orf19.2030 | Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type
6.3491364 | 3.5796711 | SAP9 | orf19.6928 | Secreted aspartyl proteinase; roles in adhesion, cell surface integrity; induced by antifungal drugs, stationary phase, or in white-phase cells; farnesol-downregulated in biofilm; autocatalytic processing; GPI-anchor; N-glycosylated
6.271349 | 3.5944412 | ALS1 | orf19.5741 | [NAME]; ALS family of cell-surface glycoproteins; adhesion, virulence roles; immunoprotective; in band at hyphal base; amyloid domain; biofilm-induced; Rfg1p, Ssk1p, growth-regulated; strain background affects expression
6.250733 | 4.615246 |  | orf19.753 | Predicted ORF in Assemblies 19, 20 and 21
5.9824834 | 3.9587646 | PI-PLC | orf19.5797 | Phosphatidylinositol (PtdIns)-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; role in, and regulated by, filamentation, Nrg1p and Tup1p; no mouse systemic virulence role; orf19.5797 and orf19.1586 are almost identical
5.8488474 | 3.169685 | FGR22 | orf19.1586 | Putative phosphatidylinositol-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; no S. cerevisiae ortholog; role in, and regulated by, filamentation; no mouse systemic virulence role; almost identical to orf19.5797
5.790668 | 5.1261697 |  | orf19.2726 | Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated
5.36679 | 3.9716132 | CRH11 | orf19.2706 | Putative ortholog of S. cerevisiae Crh1p; predicted glycosyl hydrolase domain; similar to Csf4p, to antigenic Aspergillus fumigatus Aspf9; predicted Kex2p substrate; putative GPI-anchor; localizes to cell wall; caspofungin-induced
5.353189 | 5.1072006 | [NAME] | orf19.1727 | Vacuolar calcium P-type ATPase; transcription is regulated by calcineurin and fluconazole; mutant shows increased resistance to fluconazole or lithium, and increased sensitivity to calcium
5.324931 | 4.4819894 | CSH1 | orf19.4477 | Member of aldo-keto reductase family, similar to aryl alcohol dehydrogenases; role in adhesion to fibronectin, cell surface hydrophobicity; regulated by temperature, growth phase, benomyl, macrophage interaction; azole resistance associated
5.3138795 | 9.469069500000002 | PGA31 | orf19.5302 | Cell wall protein; putative GPI anchor; expression is regulated upon white-opaque switching; induced during cell wall regeneration; possibly spurious ORF (Annotation Working Group prediction)
5.288666 | 2.4147804 | BMT3 | orf19.3282 | Putative beta-mannosyltransferase, required for addition of the 2nd beta-mannose to the acid-stable fraction of cell wall phosphopeptidomannan and for elongation of beta-mannose chains on the phosphopeptidomannan acid-labile fraction
5.277997 | 4.3068833 | PGA13 | orf19.6420 | Putative GPI-anchored protein; described as similar to mucins; induced during cell wall regeneration, and during core caspofungin response; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg and by Cyr1p, Nrg1p, Tup1p, Rlm1p
5.2479773 | 3.9510326 |  | orf19.251 | ThiJ/PfpI protein family; antigenic (Cand a 3 allergen); binds human immunoglobulin E; 2 N-glycosylation motifs; alkaline, fluconazole, Hog1p-downregulated; induced in core stress response or by oxidative stress (via Cap1p)
5.2459855 | 3.9366026 |  | orf19.7566 | Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; alkaline upregulated by Rim101p; fungal-specific (no human or murine homolog)
5.2205257 | 6.745825 |  | orf19.7296 | Predicted ORF in Assemblies 19, 20 and 21; similar to stomatin mechanoreception protein; induced by Rgt1p
5.1022515 | 4.7497373 | FLC2 | orf19.1813 | Protein involved in heme uptake; putative FAD transporter, similar to S. cerevisiae Flc2p
5.0533357 | 2.541327 | DAG7 | orf19.4688 | Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog; a-specific transcription; alpha-factor induced
4.8607883 | 3.3220682 |  | orf19.6877 | Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in response to treatment with caspofungin, ciclopirox olamine or ketoconazole; gene of core caspofungin response
4.77714 | 3.9093342 | ECM331 | [NAME] | GPI-anchored protein; mainly at plasma membrane, also at cell wall; caspofungin induced; Plc1p-regulated; repressed by Rim101p, Hog1p; colony morphology-related gene regulation by Ssn6p; induced in cyr1 homozygous null mutant yeast-form cel
4.732776999999999 | 2.940715 | [NAME] | orf19.5612 | Putative beta-mannosyltransferase, required for elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan; member of a 9-gene family; regulated by Tsa1p, Tsa1Bp
4.7249875 | 4.4115343 | ALD6 | orf19.742 | Putative aldehyde dehydrogenase; expression is regulated upon white-opaque switching; protein detected by mass spec in stationary phase cultures; transcription is upregulated in both intermediate and mature biofilms
4.583258 | 4.2317634 | UTR2 | orf19.1671 | Putative glycosidase; cell wall; role in adhesion; required for hyphal growth on [NAME] (not serum) medium; chitin-binding, glycosyl hydrolase, GPI anchor domains; induced during cell wall regeneration; mRNA detected in yeast-form cells
4.4277744 | 5.024851 | [NAME] | orf19.4377 | Predicted GPI-anchor, role in 1,6-beta-D-glucan biosynthesis; production in S. cerevisiae increases glucan content and complements killer toxin sensitivity of [NAME] mutant; possible N-linked glycosylation at Asn109; caspofungin induced
4.3430605 | 1.5489705 | PUT1 | orf19.4274 | Alkaline upregulated by Rim101p
4.276519 | 3.275366 | PHR1 | orf19.3829 | Glycosidase of cell surface; may act on cell-wall beta-1,3-glucan prior to beta-1,6-glucan linkage; E169 and E270 at active site; role in systemic but not vaginal virulence (neutral, not low pH); high pH or filamentation induced
4.2553215 | 3.6155965 | PGA52 | orf19.1911 | Putative GPI-anchored protein of unknown function; fluconazole-induced
4.057104 | 2.415573 | CRZ1 | orf19.7359 | Putative transcription factor; similar to S. cerevisiae calcineurin-regulated transcription factor [NAME]; mutant is fluconazole hypersensitive; likely to act downstream of calcineurin; has C2H2 zinc fingers; not required for mouse virulence
4.0307255 | 3.0469356 |  | orf19.5614 | Predicted ORF in Assemblies 19, 20 and 21
3.9698887 | 3.659122 |  | orf19.6264.3 | ORF Predicted by Annotation Working Group
3.9643824 | 3.0113363 | IFU5 | orf19.2568 | Predicted membrane protein; estradiol-induced; increased transcription is associated with CDR1 and CDR2 overexpression or fluphenazine treatment; gene has putative drug-responsive regulatory site; similar to S. cerevisiae Wwm1p
3.8738575 | 1.8375864 | ENA21 | orf19.5170 | Predicted ORF similar to S. cerevisiae sodium transporters Ena1p and Ena5p; Gcn4p-regulated; flucytosine, amphotericin B, or ketoconazole-induced; osmotic stress-induced; overlaps orf19.5170.1, which is annotated as a blocked reading frame
3.8279552 | 7.3164625 |  | orf19.4476 | Predicted ORF in Assemblies 19, 20 and 21
3.7449605 | 5.1480894 | ICL1 | orf19.6844 | Isocitrate lyase; enzyme of glyoxylate cycle; required for wild-type virulence in murine systemic infection; no mammalian homolog; gene induced upon phagocytosis by macrophage; farnesol regulated; Pex5p-dependent peroxisomal localization
3.6975105 | 2.143094 |  | orf19.1632 | Predicted ORF in Assemblies 19, 20 and 21
3.6779811 | 4.0710435 |  | orf19.6554 | Predicted ORF in Assemblies 19, 20 and 21
3.6531665 | 2.8409085 | CRL1 | orf19.3330 | Predicted GTPase of RHO family; CAAX motif geranylgeranylated; expression in S. cerevisiae causes dominant-negative inhibition of pheromone response
3.624813 | 3.2439458 | FLC1 | orf19.2501 | Protein involved in heme uptake; putative FAD transporter, similar to S. cerevisiae Flc1p; regulated by iron; macrophage-induced gene; mutant shows defect in filamentous growth
3.616632 | 2.8565965 | PGA1 | orf19.7625 | Putative GPI-anchored protein of unknown function; induced during cell wall regeneration
3.3486204 | 2.2342248 | [NAME] | orf19.4679 | Protein described as an amino acid permease; hyphal downregulated; regulated upon white-opaque switching; induced in core caspofungin response, during cell wall regeneration, or by flucytosine; fungal-specific (no human or murine homolog)
3.3230913 | 3.2663982 | MET13 | orf19.2887 | Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-induced; amphotericin B repressed
3.3198152 | 4.6468964 |  | orf19.7504 | Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; induced in core caspofungin response
3.2926152 | 3.0534637 |  | [NAME] | Protein similar to S. cerevisiae Sat4p; amphotericin B induced; clade-associated gene expression
3.1969535 | 3.6294634 | HMX1 | orf19.6073 | Heme oxygenase; acts in utilization of hemin iron; gene transcriptionally activated by heat, low iron, or hemin; negatively regulated by Efg1p; expression greater in low iron; upregulated by Rim101p at pH 8
3.1682966 | 2.8213382 | WH11 | orf19.3548.1 | Cytoplasmic protein expressed specifically in white phase yeast-form cells; expression in opaque cells increases virulence and frequency of opaque-to-white switching; null mutant shows wild-type switching; similar to S. cerevisiae Hsp12p
3.1272264 | 2.245391 | ROT1 | orf19.6029 | Similar to S. cerevisiae Rot1p, which is involved in cell wall 1,6-beta-glucan biosynthesis; has predicted transmembrane region
3.098998 | 2.5872254 |  | orf19.4563 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
3.069584 | 2.5854967 |  | orf19.3831 | Predicted ORF in Assemblies 19, 20 and 21
3.0226521 | 2.8830585 |  | orf19.6192 | Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; possibly spurious ORF (Annotation Working Group prediction)
3.0169234 | 3.119376 |  | orf19.6920 | Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation; possibly spurious ORF (Annotation Working Group prediction)
3.0107043 | 3.1716106 | CAR1 | orf19.3934 | Transcription is regulated by Nrg1p, Mig1p, and Tup1p; shows colony morphology-related gene regulation by Ssn6p; alkaline upregulated; protein level decreased in stationary phase cultures
2.9658267 | 2.2036057 | PHR2 | orf19.6081 | Glycosidase; role in cell wall structure; may act on beta-1,3-glucan prior to beta-1,6-glucan linkage; role in vaginal but not systemic virulence (low pH, not neutral); low pH, high iron, fluconazole induced; Rim101p-downregulated at pH 8
2.9383392 | 1.3739855 |  | orf19.7350 | Soluble protein in hyphae; fluconazole-induced; mRNA abundance is elevated in a cyr1 or ras1 null mutant and decreased mRNA abundance in an efg1 null mutant; regulated by Nrg1p, Tup1p, Tbf1p, Ssn6p
2.9346852 | 2.4400885 |  | orf19.3615 | Predicted ORF in Assemblies 19, 20 and 21; induced in core caspofungin response; increased expression observed in an ssr1 homozygous null mutant; induced by nitric oxide in yhb1 mutant
2.8960164 | 2.7307281 | CCH1 | orf19.3298 | Putative voltage-gated Ca2+ channel of the high affinity calcium uptake system; roles in thigmotropism, establishment of galvanotropism; transcription is regulated by Nrg1p and Mig1p
2.8331177 | 2.4779742 |  | orf19.242.2 | ORF Predicted by Annotation Working Group
2.8244095 | 1.1014196 | PUT2 | orf19.3974 | Alkaline upregulated; protein detected by mass spec in exponential and stationary phase cultures
2.8192117 | 3.1128 | [NAME] | orf19.4765 | Putative GPI-anchored cell-wall protein of unknown function; similar to S. cerevisiae Ccw12p/Ylr110cp; transcriptionally regulated by iron; expression greater in high iron; upregulated upon Als2p depletion
2.8011148 | 2.3883507 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21
2.7936876 | 4.2508855 | LDG3 | orf19.6486 | Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation
2.7641356 | 2.4826963 | CAS5 | orf19.4670 | Putative zinc finger transcription factor; cell wall damage response; required for wild-type transcriptional response to caspofungin; mutant caspofungin hypersensitive; downregulated in core stress response; avirulent, reduced CFU in mice
2.7625217 | 4.4035153 |  | orf19.2959.1 | ORF Predicted by Annotation Working Group
2.7132978 | 2.8408992 | [NAME] | orf19.4183 | Protein not essential for viability; similar to S. cerevisiae Muc1p, which is a cell surface glycoprotein involved in filamentous growth; decreased transcription is observed upon benomyl treatment
2.7040207 | 3.370407 | IRS4 | orf19.6953 | Protein with roles in cell wall integrity, systemic (but not oral) murine infection, adherence, hyphal growth, and agar-embedded filamentous growth; antigenic in human infection; similar to S. cerevisiae Irs4p
2.7013557 | 2.0284116 | SAC6 | orf19.5544 | Transcription is regulated by Nrg1p and Mig1p; protein level decreased in stationary phase cultures
2.674322 | 2.2825198 |  | orf19.7085 | Predicted ORF in Assemblies 19, 20 and 21; induced in core stress response; induced by heavy metal (cadmium) stress via Hog1p; oxidative stress-induced via Cap1p; induced by Mnl1p under weak acid stress; macrophage-downregulated
2.6362274 | 2.469289 | KTR4 | orf19.4475 | Protein with similarity to mannosyltransferases; induced during cell wall regeneration; fungal-specific (no human or murine homolog)
2.6332057 | 2.2378335 | CEK1 | orf19.2886 | ERK-family protein kinase, required for wild-type yeast-hyphal switching, mating efficiency, and virulence in a mouse model; Cst20p-Hst7p-Cek1p-Cph1p MAPK pathway regulates mating, and invasive hyphal growth under some conditions
2.6251628 | 1.980613 |  | orf19.1809 | Predicted 3-hydroxyacyl-CoA epimerase; upregulated upon phagocytosis; transcription is regulated by Mig1p; expression is regulated upon white-opaque switching; merged with orf19.1288 in Assembly 20
2.604817 | 1.7693262 |  | orf19.5037 | Protein not essential for viability
2.5901263 | 2.582415 |  | orf19.3438 | Predicted ORF in Assemblies 19, 20 and 21
2.5872002 | 3.3190894 | NOG2 | orf19.5732 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
2.5788503 | 2.5521016 |  | orf19.3439 | Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type
2.568056 | 2.5374913 |  | orf19.1486 | Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction)
2.534456 | 2.689919 | CZF1 | orf19.3127 | Transcriptional regulator of white-opaque switching frequency; hyphal growth regulator; has C-terminal zinc finger and central [NAME]-rich region; expression in S. cerevisiae causes dominant-negative inhibition of pheromone response
2.5244184 | 2.2086697 |  | orf19.5537 | Predicted ORF in Assemblies 19, 20 and 21
2.5178814 | 2.1426914 | [NAME] | orf19.5995 | Putative cysteine protease with similarity to S. cerevisiae Mca1p; has a role in apoptotic cell death upon [NAME] treatment; fungal-specific (no human or murine homolog); farnesol-induced
2.510556 | 3.1486235 |  | orf19.4771 | Predicted ORF in Assemblies 19, 20 and 21
2.5025938 | 4.0294223 | SAC7 | [NAME] | Protein described as a GTPase activating protein (GAP) for [NAME]; downregulated upon adherence to polystyrene; macrophage/pseudohyphal-repressed; transcription is upregulated in RHE model of oral candidiasis and in clinical oral candidiasis
2.4897523 | 2.3656864 | OPY2 | orf19.5110 | Predicted ORF in Assemblies 19, 20 and 21
2.4869475 | 2.040727 | PRC2 | orf19.4135 | Protein described as a carboxypeptidase; upregulated in the presence of human neutrophils
2.4848979 | 2.3099282 | SCP1 | orf19.17 | Predicted ORF in Assemblies 19, 20 and 21; constitutive expression independent of MTL or white-opaque status
2.4843833 | 2.166743 |  | orf19.2204 | Predicted ORF in Assemblies 19, 20 and 21
2.4293158 | 6.1044936 |  | orf19.6484 | Predicted ORF in Assemblies 19, 20 and 21
2.4207542 | 3.5504236 | HIS3 | orf19.183 | Imidazoleglycerol-phosphate dehydratase, enzyme of histidine biosynthesis; functionally complements S. cerevisiae his3-1 mutation; hyphal-induced expression; regulated by [NAME] and Gcn4p; fungal-specific (no human or murine homolog)
2.4048898 | 1.6836157 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; possibly spurious ORF (Annotation Working Group prediction)
2.3887475 | 1.8620216 | HUT1 | orf19.6803 | Predicted ORF in Assemblies 19, 20 and 21
2.3594062 | 3.0623198 |  | orf19.5070 | Predicted ORF in Assemblies 19, 20 and 21; transcriptionally regulated by iron; expression greater in low iron; similar to cell-wall mannoproteins; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; regulated by osmotic and oxidative stress via Hog1p; possibly spurious ORF (Annotation Working Group prediction)
2.355913 | 1.6147379 | ENA2 | orf19.6070 | Protein described as sodium transporter; transcription is upregulated in response to ciclopirox olamine; alkaline upregulated by Rim101p; repressed upon high-level peroxide stress; upregulated in oral candidiasis clinical isolates
2.3226445 | 2.6091204 | INN1 | orf19.2832 | Protein with similarity to S. cerevisiae Inn1p, which is an essential protein of the contractile actomyosin ring required for ingression of the plasma membrane into the bud neck during cytokinesis; contains a C2 membrane targeting domain
2.2967002 | 1.7165105 | [NAME] | [NAME] | Protein involved in sphingolipid biosynthesis; required for mannosylation of inositol phosphoceramide (IPC) to form mannosylated sphingolipids [NAME] and M(IP)2C; fluconazole, caspofungin induced; macrophage-downregulated gene
2.2943451 | 2.5847085 |  | orf19.2244 | Similar to oxidoreductases and to S. cerevisiae Yjr096wp; transcription is negatively regulated by Sfu1p; increased transcription is observed upon benomyl treatment; decreased expression observed in an ssr1 homozygous null mutant
2.2927125 | 2.0733166 | VPS1 | orf19.1949 | Protein described as a dynamin-family GTPase-related protein; induced upon adherence to polystyrene; regulated by [NAME] and Gcn4p
2.2906225 | 2.6332955 |  | orf19.192 | Predicted ORF in Assemblies 19, 20 and 21
2.2871614 | 2.2414508 |  | orf19.1766 | Predicted ORF in Assemblies 19, 20 and 21
2.2760618 | 1.445928 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21; induced in core caspofungin response; increased expression observed in an ssr1 homozygous null mutant; induced by nitric oxide in yhb1 mutant
2.2743812 | 2.28168 | ECM22 | orf19.2623 | Putative transcription factor with zinc cluster DNA-binding motif
2.2695272 | 1.7124382 | BGL2 | orf19.4565 | 1,3-beta-Glucosyltransferase, cell wall enzyme; one of multiple 1,3-beta-glucosyltransferases; mutant has cell-wall and growth defects, but wild-type 1,3- or 1,6-beta-glucan content; antigenic; virulence role in mouse systemic infection
2.267736 | 2.2766292 | MET15 | orf19.5645 | O-acetylhomoserine O-acetylserine sulfhydrylase; involved in sulfur amino acid biosynthesis; immunogenic; Hog1p, biofilm, possibly adherence-induced; brown colony color of homozygous mutant in Pb(2+) medium is visual selection marker
2.2646608 | 2.8162887 |  | orf19.1642 | Predicted ORF in Assemblies 19, 20 and 21
2.2514186 | 1.8916864 |  | orf19.6474 | Predicted ORF in Assemblies 19, 20 and 21
2.2494564 | 2.0627568 |  | orf19.5495 | Protein not essential for viability; transcription is induced in response to alpha pheromone in SpiderM medium
2.2494385 | 2.8232374 |  | orf19.2431 | Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
2.2490091 | 1.8814588 | [NAME] | orf19.2699 | Protein similar to S. cerevisiae Abp1p, which is an actin-binding protein of the cortical actin cytoskeleton; caspofungin induced; protein detected by mass spec in stationary phase cultures
2.2480042 | 3.7743845 | CHO1 | orf19.677 | Putative phosphatidylserine synthase; similar to S. cerevisiae Cho1p, which is involved in phosphatidylserine biosynthesis; transposon mutation affects filamentous growth; regulated by Nrg1p, Tup1p; no human or murine homolog
2.2271786 | 2.5894237 |  | orf19.7354 | Predicted ORF in Assemblies 19, 20 and 21; caspofungin induced
2.2072341 | 3.0764928 | DPP3 | orf19.6459 | Protein similar to S. cerevisiae pyrophosphate phosphatase Dpp1p; required for farnesol biosynthesis; downregulated in response to 17-beta-estradiol, ethynyl estradiol
2.2055233 | 2.0681536 |  | orf19.7583 | Putative transcription factor with zinc cluster DNA-binding motif; not essential for viability; filament induced
2.204474 | 2.066199 | MXR1 | orf19.2028 | Protein described as a methionine sulfoxide reductase; flucytosine induced; Plc1p-regulated; upregulated in the presence of human neutrophils; macrophage regulated (gene induced, protein decreased); possibly adherence-induced
2.19712 | 1.3744885 | SOU1 | orf19.2896 | Enzyme involved in utilization of L-sorbose; has sorbitol dehydrogenase, fructose reductase, and sorbose reductase activities; has NAD-binding site motif; transcriptional regulation affected by chromosome 5 copy number
2.1895587 | 1.5040867 |  | orf19.727 | Predicted ORF in Assemblies 19, 20 and 21; member of a family encoded by [NAME]-related genes in the RB2 repeat sequence; possibly spurious ORF (Annotation Working Group prediction)
2.1790864 | 2.2014978 | FAD3 | orf19.4933 | Omega-3 fatty acid desaturase, involved in production of alpha-linolenic acid, which is a major component of membranes; caspofungin induced; Plc1p-regulated; shows colony morphology-related gene regulation by Ssn6p
2.1671102 | 1.577713 |  | orf19.5250 | Predicted ORF in Assemblies 19, 20 and 21
2.1613057 | 2.395827 |  | orf19.5045 | Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress
2.1543329 | 2.4323893 |  | orf19.1139 | Predicted ORF in Assemblies 19, 20 and 21
2.138891 | 1.8580406 | BMT6 | orf19.5602 | Putative beta-mannosyltransferase, member of a 9-gene family that includes characterized genes BMT1, [NAME], BMT3, and [NAME] with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; predicted ORF in Assemblies 19, 20 and 21
2.1355183 | 3.192203 | REI1 | orf19.59 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
2.133835 | 1.6027666 | PRO3 | [NAME] | Protein induced during the mating process; alkaline upregulated
2.1312504 | 2.116114 |  | orf19.7084
2.1254165 | 2.0636709 |  | orf19.3815 | Predicted ORF in Assemblies 19, 20 and 21
2.1238647 | 2.1807272 | AMS1 | orf19.2768 | Putative alpha-mannosidase; transcription is regulated by Nrg1p; induced during cell wall regeneration
2.1229985 | 1.9452046 | CNS1 | orf19.6052 | Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to radicicol
2.1218317 | 1.7874432 |  | orf19.3007.2 | ORF Predicted by Annotation Working Group
2.1061885 | 1.9728754 |  | orf19.5924 | Predicted zinc-finger protein of unknown function
2.10546 | 1.7277054 |  | orf19.7495 | Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide
2.0990882 | 1.7353106 |  | orf19.246 | Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog)
2.0969846 | 1.4970636 | SSR1 | orf19.7030 | Beta-glucan associated cell-wall protein with role in cell wall structure; S/T rich protein, GPI anchor; similar mRNA abundance in yeast-form and germ tube; detected at germ tube plasma membrane by mass spec; similar to S. cerevisiae Ssr1p
2.090006 | 1.7177606 |  | orf19.14 | Predicted ORF from Assembly 19; removed from Assembly 20
2.0891328 | 2.155844 |  | orf19.5431 | Predicted ORF in Assemblies 19, 20 and 21
2.0853548 | 2.3739424 |  | orf19.5876 | Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; transcription is induced in response to alpha pheromone in SpiderM medium
2.0824208 | 1.966059 |  | orf19.158 | Predicted ORF in Assemblies 19, 20 and 21
2.0798783 | 1.9161639 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21
2.076022 | 2.0513575 |  | orf19.4900 | Predicted ORF in Assemblies 19, 20 and 21
2.0729904 | 2.1741154 |  | orf19.270 | Predicted ORF in Assemblies 19, 20 and 21
2.0661738 | 1.8597447 |  | orf19.3501 | Predicted ORF in Assemblies 19, 20 and 21; Hog1p-downregulated
2.0628226 | 1.5161996 | SEC18 | orf19.4993 | Functional homolog of S. cerevisiae Sec18p, which acts in protein transport; conserved ATP binding site; not glycosylated
2.0508323 | 2.4511986 | [NAME] | orf19.5025 | Putative ATP sulfurlyase of sulfate assimilation; repressed by Met or [NAME], Sfu1p, or in fluconazole-resistant isolate; strongly induced on biofilm formation, even in presence of Met and [NAME]; Hog1p-, caspofungin-, possibly adherence-induced
2.0501556 | 2.2949622 | AKR1 | orf19.4950 | Ankyrin-repeat protein; increased transcription is observed upon fluphenazine treatment
2.0332491 | 1.6012306 | BMT5 | orf19.1464 | Putative beta-mannosyltransferase, member of a 9-gene family that includes characterized genes BMT1, [NAME], BMT3, and [NAME] with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; predicted ORF in Assemblies 19, 20 and 21
2.0314605 | 2.4375582 | DFG5 | orf19.2075 | N-linked mannoprotein of cell wall and membrane; possible signal transducer; role in hyphal growth and HWP1 induction in alkaline pH; GPI modification predicted; dfg5 dcw1 double mutant is inviable; caspofungin-induced, fungal-specific
2.018132 | 1.8413825 |  | orf19.7531 | Predicted ORF in Assemblies 19, 20 and 21; transcription is induced upon yeast-hyphal transition; benomyl or caspofungin induced; protein detected by mass spec in stationary phase cultures
2.0065465 | 2.0524247 | FOX3 | orf19.1704 | Putative peroxisomal 3-oxoacyl CoA thiolase; expression is regulated upon white-opaque switching
1.9452044 | 2.0587735 |  | orf19.6264 | Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction)
1.9430412 | 2.5721967 |  | orf19.1091 | Putative ortholog of S. cerevisiae Nop8p, which is a nucleolar protein required for 60S ribosomal subunit biogenesis
1.9354535 | 2.9608397 | [NAME] | orf19.5500 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
1.8832952 | 2.013936 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21; hyphal-induced expression, regulated by Cyr1p, Ras1p, Efg1p; possibly spurious ORF (Annotation Working Group prediction)
1.8811563 | 2.012281 |  | orf19.6527 | Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p; transcriptionally activated by Mnl1p under weak acid stress
1.8743839 | 2.234045 | PCL1 | orf19.2649 | Cyclin homolog; expression induced upon filamentous growth; transcription is induced in response to alpha pheromone in SpiderM medium
1.8696955 | 2.0669441 | RIM101 | orf19.7247 | Transcription factor involved in alkaline pH response; required for alkaline-induced hyphal growth; role in virulence in mouse systemic infection; activated by C-terminal proteolytic cleavage; mediates both positive and negative regulation
1.8462824 | 2.0347557 | [NAME] | orf19.4890 | S/T kinase of Ste20p family; required for wild-type filamentous growth and for wild-type organ colonization and virulence in mouse systemic infection; role in chlamydospore formation; functional homolog of S. cerevisiae Cla4p
1.8168745 | 2.5095897 |  | orf19.3252 | Predicted zinc-finger protein of unknown function; has similarity to S. cerevisiae Dal81p, which is a transcription factor involved in the regulation of nitrogen-degradation genes
1.8155482 | 2.2751675 | FRP2 | orf19.7112 | Protein described as ferric reductase; alkaline upregulated by Rim101p; fluconazole-downregulated; upregulated in the presence of human neutrophils; possibly adherence-induced
1.8109454 | 4.1156116 |  | orf19.6487 | Predicted ORF in Assemblies 19, 20 and 21
1.8071615 | 2.1902544 |  | orf19.5905 | Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation
1.7924125 | 2.2818475 | RRP15 | orf19.563 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
1.7779903 | 2.7100403 |  | orf19.2167 | Predicted ORF in Assemblies 19, 20 and 21
1.7770356 | 2.072257 | UAP1 | orf19.4265 | UDP-N-acetylglucosamine pyrophosphorylase, catalyzes biosynthesis of UDP-N-acetylglucosamine from UTP and N-acetylglucosamine 1-phosphate; functional homolog of S. cerevisiae Qri1p; alkaline upregulated
1.7315643 | 2.6581054 | KRR1 | orf19.661 | Decreased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses [NAME]; induced upon biofilm formation
1.7010177 | 2.1759307 | [NAME] | orf19.5867 | Protein described as a cell wall component; increased mRNA abundance observed in cyr1 homozygous null mutant (yeast-form or hyphal cells)
1.683163 | 2.9622347 | DIM1 | orf19.5010 | Protein likely to be essential for growth, based on an insertional mutagenesis strategy; similar to S. cerevisiae Dim1p, which is an 18S rRNA dimethylase involved in rRNA modification and processing; induced upon biofilm formation
1.6673793 | 2.1355667 |  | orf19.7672 | Predicted ORF in Assemblies 19, 20 and 21
1.6623243 | 2.5570436 |  | orf19.2734 | Protein not essential for viability
1.6556586 | 2.1850944 |  | orf19.6992 | Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS)
1.6438124 | 2.0735946 |  | orf19.3826 | Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated
1.6218369 | 2.0019295 |  | orf19.5517 | Similar to alcohol dehydrogenases; increased transcription is observed upon benomyl treatment; induced by nitric oxide; induced in core stress response; oxidative stress-induced via Cap1p
1.600189 | 2.4071434 |  | orf19.3535 | Predicted ORF in Assemblies 19, 20 and 21
1.6001545 | 2.3187988 |  | orf19.6236 | Predicted ORF in Assemblies 19, 20 and 21
1.5894716 | 2.1190953 | ENP1 | orf19.5507 | Protein similar to S. cerevisiae Enp1p; transposon mutation affects filamentous growth; decreased expression in response to prostaglandins
1.5294594 | 2.1292052 |  | orf19.1404 | Predicted ORF in Assemblies 19, 20 and 21
1.3675982 | 2.5522456 |  | orf19.1146 | Predicted ORF in Assemblies 19, 20 and 21
1.2710342 | 2.1520634 |  | orf19.2330 | Predicted ORF in Assemblies 19, 20 and 21; transposon mutation affects filamentous growth; decreased expression in response to prostaglandins
1.2270132 | 3.0838943 | RBR1 | orf19.535 | [NAME] (GPI)-anchored cell wall protein required for filamentous growth at acidic pH; expression is repressed by Rim101p and activated by Nrg1p
1.219551 | 2.1326556 | RRN3 | orf19.1923 | Predicted ORF in Assemblies 19, 20 and 21; caspofungin induced, flucytosine repressed; downregulated in core stress response; decreased expression in response to prostaglandins
0.6813601 | 0.3972848 | ADE6 | orf19.6317 | Enzyme of adenine biosynthesis; not induced during GCN response, in contrast to the S. cerevisiae ortholog; protein detected by mass spec in stationary phase cultures
0.66516596 | 0.35407907 | GCV1 | orf19.5519 | Protein described as T subunit of glycine decarboxylase; transcription is negatively regulated by Sfu1p
0.660447 | 0.43914855 |  | orf19.921 | Predicted ORF in Assemblies 19, 20 and 21
0.65289176 | 0.49573272 | NDE1 | orf19.339 | Putative NADH dehydrogenase that could act alternatively to complex I in respiration; [NAME] repressed; fungal-specific (no human or murine homolog); transcription is upregulated in both intermediate and mature biofilms
0.6489676 | 0.4868682 |  | orf19.149 | Predicted ORF in Assemblies 19, 20 and 21
0.6178115 | 0.42569807 |  | orf19.4581 | Predicted ORF in Assemblies 19, 20 and 21; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions
0.61014533 | 0.4791938 | ADE5,7 | orf19.5061 | Enzyme of adenine biosynthesis; interacts with Vps34p; required for hyphal growth and virulence; flucytosine induced; not induced during GCN response, in contrast to the S. cerevisiae ortholog
0.59461683 | 0.3669064 |  | orf19.1802 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
0.5907703 | 0.323695 | [NAME] | orf19.2948 | Protein of unknown function expressed during stationary phase; transcription is regulated by Tup1p, Efg1p
0.58914167 | 0.3298646 |  | orf19.1306 | Predicted ORF in Assemblies 19, 20 and 21
0.5888956 | 0.3138566 | GAL10 | orf19.3672 | UDP-glucose 4-epimerase, required for galactose utilization; mutant shows cell wall defects and increased filamentation; fluconazole-induced; protein detected by mass spec in stationary phase cultures
0.5862544 | 0.3459363 | ERG251 | orf19.4631 | Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-induced; amphotericin B, [NAME] repressed
0.5860682 | 0.28451315 |  | orf19.1522 | Predicted ORF in Assemblies 19, 20 and 21
0.5846122 | 0.43935433 |  | orf19.5408 | Predicted ORF in Assemblies 19, 20 and 21
0.5813506 | 0.48033988 | MGE1 | orf19.2524 | Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed
0.5623348 | 0.34286198 |  | orf19.1433 | Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p
0.5596668 | 0.418614 | SHM2 | orf19.5750 | Cytoplasmic serine hydroxymethyltransferase; complements the glycine auxotrophy of an S. cerevisiae shm1 null shm2 null gly1-1 triple mutant; antigenic in human; soluble protein in hyphae; farnesol-upregulated in biofilm
0.55880016 | 0.43643582 | NPR1 | orf19.6232 | Predicted ORF in Assemblies 19, 20 and 21; induced in core stress response
0.5582442 | 0.44655192 | MIS11 | orf19.2364 | Similar to precursor of mitochondrial C1-tetrahydrofolate synthase; putative protein of glycine catabolism; downregulated by Efg1p; fluconazole-induced; protein detected by mass spec in stationary phase cultures
0.5524067 | 0.48502615 |  | orf19.719 | Predicted ORF in Assemblies 19, 20 and 21
0.55145437 | 0.42007333 |  | orf19.1593 | Protein not essential for viability; similar to S. cerevisiae Rim11p, which is a protein kinase involved in meiosis and sporulation; merged with orf19.791 in Assembly 20
0.55113876 | 0.48150748 | [NAME] | orf19.3554 | Protein described as aspartate aminotransferase; soluble protein in hyphae; macrophage-induced protein; alkaline upregulated; amphotericin B repressed; gene used for strain identification by multilocus sequence typing, farnesol-induced
0.5510601 | 0.463088 |  | orf19.1352 | Predicted ORF in Assemblies 19, 20 and 21
0.5392976 | 0.40537277 |  | orf19.3678 | Protein not essential for viability
0.5329354 | 0.445297 |  | orf19.7325 | Predicted ORF in Assemblies 19, 20 and 21
0.52941835 | 0.39068946 |  | orf19.4550 | Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS)
0.52885824 | 0.40508085 | TPS1 | orf19.6640 | Trehalose-6-phosphate synthase; role in hyphal growth and virulence in mouse systemic infection; upregulated in presence of human neutrophils; macrophage/pseudohyphal-repressed after 16h; detected by mass spec in stationary phase cultures
0.52670765 | 0.3651114 | ADE13 | orf19.3870 | Enzyme of adenine biosynthesis; soluble protein in hyphae; not induced during GCN response, in contrast to the S. cerevisiae ortholog; repressed by nitric oxide
0.5265973 | 0.41415262 | HRT2 | orf19.4624 | Protein described as having a role in Ty3 transposition; decreased expression in hyphae compared to yeast-form cells; protein detected by mass spec in stationary phase cultures
0.5265443 | 0.47898614 |  | orf19.461 | Protein similar to S. cerevisiae Mhp1p, which is involved in microtubule stabilization; transposon mutation affects filamentous growth; merged with orf19.6621 in Assembly 20
0.5211565 | 0.48424459 | TPS3 | orf19.5348 | Protein described as regulatory subunit of trehalose-phosphate synthase; regulated by Efg1p; biofilm-repressed expression; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions
0.5180137 | 0.3165508 | GPD1 | orf19.1756 | Protein similar to S. cerevisiae glycerol-3-phosphate dehydrogenase (enzyme of glycerol biosynthesis); biofilm-induced expression; regulated by Efg1p; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions
0.50217104 | 0.46653014 | DES1 | orf19.4048 | Putative delta-4 sphingolipid desaturase
0.49958333 | 0.4661439 | MDH1-3 | orf19.5323 | Predicted malate dehydrogenase; farnesol regulated
0.49835938 | 0.4913282 |  | orf19.1172 | Protein similar to phosphate transporters; regulated upon white-opaque switching or biofilm formation; Hog1p, ciclopirox olamine or alkaline induced; caspofungin or stress repressed; merged with orf19.655 in Assembly 20
0.49803567 | 0.31924424 | SUR2 | orf19.5818 | Protein described as similar to ceramide hydroxylase; predicted enzyme of sphingolipid biosynthesis; upregulated in biofilm; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions
0.49719265 | 0.29216734 | GCV2 | orf19.385 | Putative protein of glycine catabolism; downregulated by Efg1p; Hog1p-induced; upregulated by Rim101p at acid pH; transcription is activated in the presence of elevated CO2; protein detected by mass spec in stationary phase cultures
0.49577934 | 0.5334233 | ACS1 | orf19.1743 | Putative acetyl-CoA synthetase, similar to S. cerevisiae Acs1p; upregulated in the presence of human neutrophils; fluconazole-downregulated; regulated by Nrg1p and Mig1p; shows colony morphology-related gene regulation by Ssn6p
0.4945748 | 0.5347172 |  | orf19.3881 | Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction)
0.49425712 | 0.39902037 | XKS1 | orf19.1290 | Predicted ORF in Assemblies 19, 20 and 21; increased expression in response to prostaglandins
0.48983443 | 0.4648914 | DAP1 | orf19.489 | Protein similar to S. cerevisiae Dap1p, which is a protein related to mammalian membrane-associated progesterone receptors involved in response to DNA damage; induced in core stress response; Hog1p regulated; clade-associated expression
0.4897612 | 0.62145656 | LEU1 | orf19.7498 | Protein described as 3-isopropylmalate dehydratase; antigenic in human; decreased expression in hyphae compared to yeast-form cells; alkaline downregulated; upregulated in the presence of human whole blood or polymorphonuclear (PMN) cells
0.48926273 | 0.4883039 |  | orf19.5620 | Predicted ORF in Assemblies 19, 20 and 21; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment); increased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses [NAME]
0.4886887 | 0.4375879 | IDP2 | orf19.3733 | Putative isocitrate dehydrogenase; expression is regulated upon white-opaque switching; shows colony morphology-related gene regulation by Ssn6p; protein detected by mass spec in exponential and stationary phase cultures
0.4868477 | 0.4569183 |  | orf19.3175 | Predicted ORF in Assemblies 19, 20 and 21; alkaline downregulated; repressed by nitric oxide; virulence-group-correlated expression
0.48555195 | 0.41300184 | STF2 | orf19.2107.1 | Protein involved in ATP biosynthesis; decreased expression in hyphae compared to yeast-form cells; downregulated by Efg1p; transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis
0.4832665 | 0.6722261 |  | orf19.822 | Protein detected in some, not all, biofilm extracts; fluconazole-downregulated; greater mRNA abundance observed in cyr1 or ras1 homozygous null mutant than in wild type; protein detected by mass spec in stationary phase cultures
0.48249394 | 0.5239277 |  | orf19.3406 | Predicted ORF in Assemblies 19, 20 and 21; member of conserved Mcm1p regulon
0.48240423 | 0.38474315 | FMP27 | orf19.3422 | Predicted ORF in Assemblies 19, 20 and 21; fungal-specific (no human or murine homolog)
0.48045638 | 0.43439743 |  | orf19.4185 | Predicted ORF in Assemblies 19, 20 and 21
0.4768771 | 0.47277796 | PTR2 | orf19.6937 | Putative oligopeptide transporter; regulated by Stp2p and Stp3p; transcriptionally induced upon phagocytosis by macrophage; downregulated by Rim101p at pH 8
0.4765929 | 0.57831305 | XYL2 | orf19.7676 | Protein described as similar to D-xylulose reductase; immunogenic in mouse; soluble protein in hyphae; Hog1p-induced; induced during cell wall regeneration; caspofungin or fluconazole-induced; Mnl1p-induced in weak acid stress
0.4760511 | 0.4808673 | AOX2 | orf19.4773 | Alternative oxidase; induced by antimycin A, some oxidants; growth- and carbon-source-regulated; one of two isoforms (Aox1p and Aox2p); involved in cyanide-resistant respiratory pathway that is absent from S. cerevisiae
0.47580636 | 0.41091135 | RHD3 | orf19.5305 | Putative GPI-anchored protein that localizes to the cell wall; transcription is decreased upon yeast-hyphal switch; transcriptionally regulated by iron; expression greater in high iron; clade-associated gene expression
0.47410733 | 0.41449606 |  | orf19.3364 | Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction)
0.47098738 | 0.44126818 | CAF16 | orf19.388 | ABC family protein, predicted not to be a transporter; [NAME] repressed
0.46868983 | 0.4647538 |  | orf19.6770 | Predicted ORF in Assemblies 19, 20 and 21
0.4676785 | 0.60706294 |  | orf19.1189 | Predicted ORF in Assemblies 19, 20 and 21; transcription regulated upon yeast-hyphal switch; transcriptionally activated by Mnl1p under weak acid stress
0.46656835 | 0.364035 |  | orf19.3641 | Expression is regulated upon white-opaque switching; merged with orf19.84 in Assembly 20
0.46395278 | 0.43505678 |  | orf19.4998 | Predicted ORF in Assemblies 19, 20 and 21; [NAME] repressed
0.46374467 | 0.4105178 |  | orf19.5293 | Predicted ORF in Assemblies 19, 20 and 21
0.46333572 | 0.2831269 | ZRT2 | orf19.1585 | Protein described as predicted zinc transporter; ciclopirox olamine, fluconazole, or alkaline downregulated; transcriptionally induced by interaction with macrophage; amphotericin B induced
0.46185136 | 0.4503451 |  | orf19.3004 | Predicted ORF in Assemblies 19, 20 and 21
0.46033567 | 0.32988715 |  | orf19.4738 | Predicted ORF in Assemblies 19, 20 and 21
0.4586014 | 0.35904378 | PGA48 | orf19.6321 | Putative GPI-anchored protein of unknown function; similar to S. cerevisiae Spi1p, which is induced at stationary phase; transcriptionally regulated by iron; expression greater in high iron
0.45851052 | 0.45146632 | EAF6 | orf19.396 | Subunit of the NuA4 histone acetyltransferase complex
0.45801294 | 0.3502704 | PHO84 | orf19.655 | Protein similar to high-affinity phosphate transporters; expression is regulated upon white-opaque switching or biofilm formation; Hog1p, ciclopirox olamine or alkaline induced; caspofungin or stress repressed; upregulated in RHE model
0.45782298 | 0.2075196 | SCW11 | orf19.3893 | Cell wall protein; transcription is decreased in mutant lacking [NAME]; downregulated in core caspofungin response; transcriptionally regulated by iron; expression greater in high iron
0.4563012 | 0.4287367 | MIG1 | orf19.4318 | Transcriptional repressor; regulates genes for utilization of carbon sources; Tup1p-dependent and -independent functions; upregulated in biofilm; hyphal downregulated; [NAME] repressed; functional homolog of S. cerevisiae Mig1p
0.4560062 | 0.4716832 |  | orf19.846 | Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress
0.45558214 | 0.46003634 |  | orf19.5628 | Predicted ORF in Assemblies 19, 20 and 21
0.4524146 | 0.56352806 |  | orf19.6978 | Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction)
0.45241424 | 0.4095938 | [NAME] | [NAME] | Protein similar to phosphate permeases; transcription is negatively regulated by Rim101p at pH 8; expression is regulated upon white-opaque switching; [NAME] repressed; biofilm-regulated; virulence-group-correlated expression
0.450901 | 0.50508034 |  | orf19.7473 | Predicted ORF in Assemblies 19, 20 and 21
0.45057642 | 0.44811437 | [NAME] | orf19.4195.1 | Cytosine deaminase; enzyme of pyrimidine salvage; functional homolog of S. cerevisiae Fcy1p; mutation is associated with resistance to flucytosine (5-FC) in a clinical isolate; hyphal downregulated; gene has intron
0.44940725 | 0.5366325 |  | orf19.6833 | Predicted ORF from Assembly 19; merged with orf19.6832 in Assembly 20
0.44920862 | 0.43874708 | CDC20 | orf19.122 | Protein similar to S. cerevisiae Cdc20p, which is a cell-cycle regulated activator of the anaphase promoting complex; induced under Cdc5p depletion; member of conserved Mcm1p regulon; periodic mRNA expression, peak at cell-cycle G2/M phase
0.44826254 | 0.49903584 |  | orf19.2261 | Predicted ORF in Assemblies 19, 20 and 21
0.44682434 | 0.31130424 |  | orf19.7459 | Predicted ORF in Assemblies 19, 20 and 21; fluconazole-induced; ketoconazole-repressed
0.44537985 | 0.3748606 |  | orf19.5282 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in hyphae compared to yeast-form cells; regulated by Efg1p and Efh1p; intron in 5'-UTR; transcriptionally activated by Mnl1p under weak acid stress
0.44109556 | 0.64169884 | PDR16 | orf19.1027 | Phosphatidylinositol transfer protein; increased transcription correlates with CDR1 and CDR2 overexpression and azole resistance; induced by fluphenazine, 17-beta-estradiol, ethynyl estradiol, nitric oxide; farnesol-downregulated in biofilm
0.43830004 | 0.39353997 |  | orf19.2414 | Predicted ORF in Assemblies 19, 20 and 21
0.43407208 | 0.40094954 |  | orf19.951 | Predicted ORF in Assemblies 19, 20 and 21; transcription downregulated upon yeast-hyphal switch; fluconazole-induced; possibly spurious ORF (Annotation Working Group prediction)
0.43323562 | 0.8091057 |  | orf19.4964 | Predicted ORF in Assemblies 19, 20 and 21
0.43319443 | 0.36334264 |  | orf19.6816 | Predicted ORF in Assemblies 19, 20 and 21
0.4293848 | 0.2702304 | GAL7 | orf19.3675 | Predicted ORF in Assemblies 19, 20 and 21; macrophage/pseudohyphal-repressed
0.42857867 | 0.4091151 |  | orf19.1788 | Predicted ORF from Assembly 19; merged with orf19.1290 in Assembly 20
0.4280886 | 0.242905 |  | orf19.7104 | Predicted ORF in Assemblies 19, 20 and 21; similar to mucins and to a Litomosoides microfilarial sheath protein
0.4267928 | 0.46799722 | PTC8 | orf19.4698 | Predicted type 2C protein phosphatase, serine/threonine-specific; required for hyphal growth; induced under stress
0.4259395 | 0.39441574 |  | orf19.5334 | Predicted ORF in Assemblies 19, 20 and 21; transcription regulated upon yeast-hyphal switch
0.41910246 | 0.45882955 |  | orf19.6983 | Predicted ORF in Assemblies 19, 20 and 21; repressed by nitric oxide
0.41872215 | 0.34804222 |  | orf19.3302 | Predicted ORF in Assemblies 19, 20 and 21; transcription downregulated upon yeast-hyphal switch; transcriptionally activated by Mnl1p under weak acid stress
0.4141365 | 0.6051747 | PFK1 | orf19.3967 | Alpha subunit of phosphofructokinase (PFK), which is Pfk1p, Pfk2p heteromultimer; PFK is activated by fructose 2,6-bisphosphate or AMP, inhibited by ATP; activity reduced on hyphal induction; phagocytosis-downregulated; fluconazole-induced
0.41367024 | 0.42542347 | PGA53 | orf19.4651 | Putative GPI-anchored protein of unknown function; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type
0.4114094 | 0.30831984 | GPM2 | orf19.1067 | Protein described as phosphoglycerate mutase; decreased expression in hyphae compared to yeast-form cells; macrophage/pseudohyphal-repressed; induced by high levels of peroxide stress, farnesol-induced
0.4088575 | 0.34169522 |  | orf19.4450.1 | ORF Predicted by Annotation Working Group
0.40773854 | 0.41150275 | PHO15 | orf19.4444 | Protein described as 4-nitrophenyl phosphatase; hyphal downregulated; induced in core stress response; induced by heavy metal (cadmium) stress via Hog1p
0.40076563 | 0.36042398 | CBP1 | orf19.7323 | Corticosteroid binding protein; transcription induced at late log-phase or upon adherence to polystyrene; not induced by corticosterone; contains a possible NAD/FAD binding region; regulated by Nrg1p, Tup1p
0.40028128 | 0.39155212 |  | orf19.2658 | Predicted ORF from Assembly 19; merged with orf19.1352 in Assembly 20
0.39946228 | 0.3215935 | VTC4 | orf19.3363 | Protein described as polyphosphate synthetase; decreased expression in hyphae compared to yeast-form cells; fungal-specific (no human or murine homolog); virulence-group-correlated expression
0.39727882 | 0.5290698 | HOM32 | orf19.6959 | [NAME] 4-P-transferase; fungal-specific (no human or murine homolog); removed from Assembly 20
0.3909906 | 0.36099005 | [NAME] | orf19.3618 | Protein with suggested role in dispersal in host; mutation causes increased adhesion and biofilm formation; putative GPI-anchor; cell wall and secreted; has stable propeptide; regulated by growth phase, phosphate, Ssk1p, Ssn6p, Efg1p, Efh1p
0.3905495 | 0.44049332 | CTA9 | orf19.3315 | Protein induced during the mating process; activates transcription in 1-hybrid assay in S. cerevisiae
0.39046904 | 0.33822313 | RIB3 | [NAME] | 3,4-Dihydroxy-2-butanone 4-phosphate synthase; homodimeric enzyme of riboflavin biosynthesis; converts ribulose 5-phosphate to L-3,4-dihydroxy-2-butanone 4-phosphate; transcription regulated on yeast-hyphal switch, macrophage interaction
0.389388 | 0.36424565 | RAD16 | orf19.2969 | Protein similar to S. cerevisiae Rad16p; flucytosine induced
0.38668296 | 0.30379742 | PDX3 | orf19.550 | Transcription is regulated upon yeast-hyphal switch; regulated by Nrg1p, Mig1p, and Tup1p; [NAME] repressed; protein detected by mass spec in exponential and stationary phase cultures
0.3866209 | 0.19877298 | OPT1 | orf19.2602 | Oligopeptide transporter; transports 3-to-5-residue peptides; alleles are distinct, one has intron; not ABC or PTR type transporter; suppresses S. cerevisiae ptr2-2 mutant defects; induced by BSA or peptides; Stp3p, Hog1p regulated
0.38374084 | 0.28998893 |  | orf19.13 | Putative glucokinase; regulated upon yeast-hyphal switch; regulated by Efg1p; fluconazole-induced; induced in core stress response; shows colony morphology-related gene regulation by Ssn6p; merged with orf19.734 in Assembly 20
0.38342348 | 0.34877068 | OPT9 | orf19.2584 | Probable pseudogene similar to fragments of OPT1 oligopeptide transporter gene; decreased expression in hyphae compared to yeast-form cells; transcriptionally induced upon phagocytosis by macrophage
0.38287294 | 0.32866833 |  | orf19.915 | Predicted ORF in Assemblies 19, 20 and 21
0.3823355 | 0.26867107 | QDR1 | orf19.508 | Putative transporter of antibiotic resistance; transcription is regulated by Nrg1p and Tup1p; [NAME] repressed; expression is regulated upon white-opaque switching
0.3806331 | 0.34837148 |  | orf19.3448 | Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-repressed; possibly spurious ORF (Annotation Working Group prediction)
0.38001648 | 0.44854805 | PCL7 | orf19.6225 | Protein described as cyclin-like, possible Pho85p cyclin; hyphal downregulated; transcriptionally activated by Mnl1p under weak acid stress
0.37994578 | 0.13346376 | FGR41 | orf19.4910 | Putative GPI-anchored protein; transposon mutation affects filamentous growth; possibly spurious ORF (Annotation Working Group prediction)
0.37760392 | 0.42745343 |  | orf19.2125.1 | ORF Predicted by Annotation Working Group; removed from Assembly 20
0.3768348 | 0.3375747 | UCF1 | orf19.1354 | Transcriptionally regulated by iron or by yeast-hyphal switch; expression greater in high iron, decreased upon yeast-hyphal switch; downregulation correlates with clinical development of fluconazole resistance; Ras1p-regulated
0.3713699 | 0.23376276 | FTR1 | orf19.7219 | High-affinity iron permease (ferric citrate, ferrioxamines E or B, transferrin); required for mouse virulence, low-iron growth; iron, amphotericin B, caspofungin, ciclopirox, Hog1p regulated; complements S. cerevisiae ftr1 iron transport
0.36688262 | 0.27192068 | GLK1 | [NAME] | Putative glucokinase; transcription is regulated upon yeast-hyphal switch; transcriptionally regulated by Efg1p; fluconazole-induced; induced in core stress response; shows colony morphology-related gene regulation by Ssn6p
0.36311838 | 0.30466664 |  | orf19.7227 | Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog
0.36125982 | 0.33528996 |  | orf19.6119 | Predicted ORF in Assemblies 19, 20 and 21
0.3590428 | 0.22645053 |  | orf19.2048 | Transcription is positively regulated by Sfu1p
0.35887364 | 0.43131188 |  | orf19.1653 | Predicted ORF in Assemblies 19, 20 and 21; possibly spurious ORF (Annotation Working Group prediction)
0.3587896 | 0.29471633 | TPS2 | orf19.3038 | Trehalose-6-phosphate (Tre6P) phosphatase; mutation causes heat sensitivity, Tre6P accumulation, and decreased mouse virulence; possible drug target; two conserved phospohydrolase motifs; no human or murine homolog
0.35645595 | 0.31426176 | BUB3 | orf19.2655 | Protein similar to S. cerevisiae Bub3p, which is a kinetochore checkpoint component; induced under hydroxyurea treatment
0.3559798 | 0.49746096 | PGA10 | orf19.5674 | Plasma membrane protein involved in heme-iron utilization; allows utilization of hemin and hemoglobin as iron sources in host tissues; predicted GPI anchor; hypoxia, ketoconazole, ciclopirox, or hyphal-induced; upregulated by Rim101p at pH8
0.3528407 | 0.26958197 |  | orf19.2659 | Predicted ORF from Assembly 19; downregulation correlates with clinical development of fluconazole resistance; decreased expression in hyphae compared to yeast-form cells; Ras1p-regulated; merged with orf19.1354 in Assembly 20
0.34421912 | 0.34239718 |  | orf19.4013 | Predicted ORF in Assemblies 19, 20 and 21
0.34390938 | 0.27618423 |  | orf19.1034 | Predicted ORF in Assemblies 19, 20 and 21; [NAME] repressed
0.34175608 | 0.35548896 |  | orf19.1381 | Predicted ORF in Assemblies 19, 20 and 21
0.34113958 | 0.3219811 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21
0.34086224 | 0.4016507 | VTC3 | orf19.4381 | Putative polyphosphate synthetase; downregulated in core caspofungin response; Hog1p-induced; transcription is opaque-specific; fungal-specific (no human or murine homolog)
0.33635756 | 0.22834322 | DAK2 | orf19.4777 | Protein described as similar to dihydroxyacetone kinase; transcription is decreased upon yeast-hyphal switch; fluconazole-induced; [NAME] repressed; protein detected by mass spec in stationary phase cultures
0.33393317 | 0.2635654 | MAF1 | orf19.2173 | Protein described as affecting nucleocytoplasmic transport and synthesis of RNA Polymerase III; decreased expression in hyphae compared to yeast-form cells; [NAME] repressed
0.33292112 | 0.24080324 | [NAME] | orf19.3656 | Transcription is regulated by Nrg1p and Tup1p; alkaline downregulated
0.3292037 | 0.28567427 | CMK1 | orf19.5911 | Expression is regulated upon white-opaque switching; biochemically purified Ca2+/CaM-dependent kinase is soluble, cytosolic, monomeric, and serine-autophosphorylated
0.32697767 | 0.26013958 | [NAME] | orf19.3278 | Protein described as glycogen synthase; enzyme of glycogen metabolism; transcription downregulated upon yeast-hyphal switch and regulated by Efg1p; strong oxidative stress induced; shows colony morphology-related gene regulation by Ssn6p
0.32037836 | 0.34495637 | ERG3 | orf19.767 | C-5 sterol desaturase; introduces C-5(6) double bond into episterol in ergosterol biosynthesis; clinically-isolated homozygous null mutants show azole resistance, defects in hyphal growth and virulence; Efg1p-repressed; fluconazole-induced
0.31770763 | 0.36453938 | CBF1 | orf19.2876 | Transcription factor that binds to a conserved sequence at ribosomal protein genes and the rDNA locus, with Tbf1p; also regulates sulfur starvation-response and other genes; binds centromeres and has a role in centromere maintenance
0.31306788 | 0.28428292 | MSN4 | orf19.4752 | Putative zinc finger transcription factor; similar to S. cerevisiae Msn4p, but not a significant stress response regulator in C. albicans; partly complements STRE-activation defect of S. cerevisiae msn2 msn4 double mutant
0.31172392 | 0.27122936 | HEM13 | orf19.2803 | Coproporphyrinogen III oxidase; antigenic in human, mouse; localizes to yeast-form cell surface, not hyphae; soluble in hyphae; iron-regulated expression; macrophage-downregulated protein; not Rfg1p regulated, farnesol-induced
0.3073995 | 0.33115032 |  | orf19.2223 | Predicted ORF from Assembly 19; removed from Assembly 20
0.3063148 | 0.30003726 |  | [NAME] | Predicted ORF from Assembly 19; merged with orf19.2866 in Assembly 20
0.30107993 | 0.38160792 |  | orf19.4907 | Predicted ORF in Assemblies 19, 20 and 21; increased transcription is observed upon fluphenazine treatment; possibly transcriptionally regulated by Tac1p; induced by nitric oxide; fungal-specific (no human or murine homolog)
0.29592723 | 0.15564646 | ENG1 | orf19.3066 | Endo-1,3-beta-glucanase required for cell separation after division, orthologous to S. cerevisiae Dse4p; [NAME] repressed; fungal-specific (no human or murine homolog); repressed in response to alpha pheromone in SpiderM medium
0.28706756 | 0.22013174 | TPO3 | orf19.4737 | Possible role in polyamine transport; MFS-MDR family; transcription induced by Sfu1p, regulated upon white-opaque switching; decreased expression in hyphae compared to yeast-form cells; regulated by Nrg1p; fungal-specific
0.2857035 | 0.2584426 | FET34 | orf19.4215 | Protein similar to multicopper ferroxidase; expression greater in low iron and reduced in a fluconazole-resistant isolate; downregulated by Sfu1p, Hog1p; alkaline upregulated by Rim101p; ciclopirox olamine induced
0.27915823 | 0.3311585 |  | orf19.1314 | Predicted ORF in Assemblies 19, 20 and 21
0.27820563 | 0.25246796 | UPC2 | orf19.391 | Transcriptional regulator of ergosterol biosynthetic genes and sterol uptake; binds ERG2 promoter; has Zn(2)-Cys(6) binuclear cluster; induced upon ergosterol depletion, by azoles, anaerobicity; macrophage/pseudohyphal-repressed
0.2779241 | 0.13401951 | PGA38 | orf19.2758 | Putative GPI-anchored protein of unknown function; repressed during cell wall regeneration
0.27428 | 0.26219735 | MAE1 | [NAME] | Malic enzyme, mitochondrial; transcription regulated by Mig1p and Tup1p; shows colony morphology-related gene regulation by Ssn6p
0.26876774 | 0.33438686 |  | orf19.2866 | Predicted ORF in Assemblies 19, 20 and 21
0.26337495 | 0.2855061 |  | orf19.411 | Protein described as similar to GTPase regulators; possibly spurious ORF (Annotation Working Group prediction); transcriptionally regulated by iron; expression greater in low iron; transcriptionally activated by Mnl1p under weak acid stress
0.2593295 | 0.29772502 |  | orf19.3820 | Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression
0.25600266 | 0.2679407 | ERG1 | orf19.406 | Squalene epoxidase, catalyzes epoxidation of squalene to 2,3(S)-oxidosqualene in the ergosterol biosynthetic pathway; essential; target of allylamine antifungal drugs; uses NADH as a reducing cofactor, while S. cerevisiae Erg1p uses NADPH
0.24326801 | 0.27446398 |  | orf19.7396 | Predicted ORF in Assemblies 19, 20 and 21
0.24180937 | 0.31805933 |  | [NAME] | Predicted ORF in Assemblies 19, 20 and 21
0.2394259 | 0.29028556 | PGA45 | orf19.2451 | Cell wall protein; putative GPI-anchor; downregulated in core caspofungin response; Hog1p-induced; regulated by Ssn6p; Mob2p-dependent hyphal regulation; possibly spurious ORF (Annotation Working Group prediction)
0.23523526 | 0.34952223 | SYG1 | [NAME] | Protein not essential for viability; similar to S. cerevisiae Syg1p, which is a plasma membrane protein that may be involved in signal transduction
0.20612183 | 0.11839119 | [NAME] | orf19.7586 | Chitinase, major; functional homolog of S. cerevisiae Cts1p; 4 N-glycosylation motifs; possible O-mannosylated region; putative signal peptide; hyphal-repressed; farnesol upregulated in biofilm; regulated by Efg1p, Cyr1p, Ras1p
0.2006374 | 0.12780175 |  | orf19.670.2 | ORF Predicted by Annotation Working Group
0.19217211 | 0.22362427 | FRE10 | orf19.1415 | Major cell-surface ferric reductase under low-iron conditions; 7 transmembrane regions and a secretion signal predicted; repressed by Tup1p, Rim101p, Ssn6p, Hog1p, caspofungin; ciclopirox olamine induced; not required for filamentous growth
0.1888397 | 0.15700036 | IFE2 | orf19.5288 | Protein described as an alcohol dehydrogenase; decreased expression in hyphae compared to yeast-form cells; Efg1p-regulated; fluconazole-induced; Hog1p-induced; increased expression in response to prostaglandins
0.18282996 | 0.08351415 |  | orf19.5267 | Putative cell wall protein; downregulated in core caspofungin response; transcription is repressed in response to alpha pheromone in SpiderM medium; transcription repressed in ace2 null mutant
0.1561372 | 0.16945897 | CDR4 | orf19.5079 | Putative transporter of ATP-binding cassette (ABC) superfamily; fluconazole, Sfu1p, Hog1p, core stress response induced; [NAME]; fluconazole resistance is not affected by mutation or correlated with expression
0.15320598 | 0.14886455 | RNR22 | orf19.1868 | Protein described as ribonucleoside diphosphate reductase; shows colony morphology-related gene regulation by Ssn6p; RNA abundance regulated by tyrosol and cell density
0.13723235 | 0.17398725 | HGT6 | orf19.2020 | Putative glucose transporter of major facilitator superfamily; 20 members of C. albicans glucose transporter family; 12 probable membrane-spanning segments; core stress response, fluconazole-induced; expressed in rich medium with 2% glucose
0.13717963 | 0.10090931 |  | orf19.1691 | Predicted ORF in Assemblies 19, 20 and 21; fluconazole-induced; filament induced; Hog1p-induced; regulated by Nrg1p, Tup1p; increased expression in response to prostaglandins