Spreadsheet: c2d3463d-593e-4273-ac1d-80d6c4bc1b6e
Sheet: Sheet1

Table. S2. Proteins significantly changed in the culture supernatants of (ΔhrtA+ hemin) compared to (ΔhrtA- hemin). | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7
 |  | ΔhrtA - hemin |  | ΔhrtA + hemin
Protein1 | Description2 | Mean3 | SD4 | Mean3 | SD4 | p value5 | ΔhrtA+hemin/ΔhrtA-hemin6
gi|150373034 | |dbj|BAF66294.1| conserved hypothetical protein | 2.325898070418295 | 1.695620898196688 | 11.1025581409699 | 2.607816778096327 | 0.0081193466980761 | 4.773449998594818
gi|150373374 | |dbj|BAF66634.1| conserved hypothetical protein | 183.7703213731831 | 24.83608919050178 | 238.3354234427059 | 22.15565525854591 | 0.04688460626765048 | 1.296920099294583
[NAME] | |dbj|BAF66660.1| exotoxin NM1 | 20.42046310806598 | 1.868491001068463 | 218.7312182828521 | 21.33066162179349 | 8.8310405114378e-05 | 10.71137403325855
gi|150373401 | |dbj|BAF66661.1| exotoxin NM2 | 14.8082054898946 | 1.387205977517195 | 55.91723458270693 | 16.40252499640311 | 0.01239324941524293 | 3.776097962772457
gi|150373402 | |dbj|BAF66662.1| exotoxin NM3 | 7.31436315495329 | 2.106794648189121 | 29.73722505799718 | 5.40073143470794 | 0.002582776947233403 | 4.065593193559048
gi|150373403 | |dbj|BAF66663.1| exotoxin NM4 | 12.52328373033568 | 3.710868858715676 | 77.89276131425227 | 18.51062384412419 | 0.003888860279777638 | 6.219835227845981
gi|150373404 | [NAME] exotoxin NM5 | 2.055860263956408 | 2.694537688856165 | 28.51966733850329 | 7.118936323009336 | 0.003831312925332479 | 13.87237636648441
gi|150373406 | [NAME] exotoxin NM7 | 104.8574056296566 | 14.89507023359308 | 366.2912064362335 | 33.78289469474053 | 0.0002538283205054157 | 3.493231634300858
gi|150373407 | |dbj|BAF66667.1| exotoxin NM8 | 8.425209652091288 | 1.171160076619971 | 34.1606361679241 | 9.32867769986714 | 0.009030097058209213 | 4.054574019940834
gi|150373408 | |dbj|BAF66668.1| exotoxin NM9 | 5.766045009928177 | 1.4406360361785 | 53.06089254003569 | 15.04799388615553 | 0.005620952877207265 | 9.20230286941458
gi|150373409 | |dbj|BAF66669.1| exotoxin NM10 | 12.40883457647853 | 1.366868681494099 | 41.77851763175162 | 11.76803042286923 | 0.01270740601504002 | 3.366836536844851
gi|150373414 | |dbj|BAF66674.1| conserved hypothetical protein | 4.501411121033383 | 1.225024393163277 | 8.558853042485701 | 1.494692289095898 | 0.02203336226239791 | 1.901371106161229
gi|150373770 | |dbj|BAF67030.1| extracellular matrix and plasma binding protein | 78.65364854029816 | 3.465372909619291 | 216.7543565471068 | 22.50046844799749 | 0.0004639508029644825 | 2.755808033953477
gi|150373842 | |dbj|BAF67102.1| glycerophosphoryl diester phosphodiesterase | 12.69251883260885 | 0.982327763415732 | 23.32503012902727 | 1.800675898108755 | 0.0008517308930314265 | 1.837699075860499
gi|150374078 | |dbj|BAF67338.1| conserved hypothetical protein | 10.16325105481926 | 1.586467196771935 | 16.45419514603382 | 0.4132241669345076 | 0.002660298673837996 | 1.618989342807928
gi|150374081 | |dbj|BAF67341.1| conserved hypothetical protein | 18.65853117795473 | 3.213542609929158 | 96.27954689956762 | 5.400745135629752 | 2.823407490929535e-05 | 5.160081786787322
gi|150374088 | |dbj|BAF67348.1| conserved hypothetical protein | 22.61142386919745 | 3.577371336628454 | 59.12619961789844 | 7.344085759496726 | 0.001499321996770713 | 2.614881750036249
gi|150374089 | [NAME] conserved hypothetical protein | 2.698502880062766 | 3.019658803169742 | 9.812461565330926 | 1.449131794155151 | 0.02122603115155522 | 3.63626129059484
gi|150375411 | |dbj|BAF68671.1| fibronectin binding protein A precursor | 1.618388616069294 | 0.550790735690206 | 6.93106540505979 | 1.139640481351681 | 0.001901832574303926 | 4.282695352797157
gi|151220605 | |ref|YP_001331427.1| exotoxin NM6 | 3.570043803883404 | 0.4906563264519179 | 59.06422019806237 | 12.19382661092018 | 0.001404740130481372 | 16.54439649558747
gi|151220614 | |ref|YP_001331436.1| conserved hypothetical protein | 4.501411121033383 | 1.225024393163277 | 8.558853042485701 | 1.494692289095898 | 0.02203336226239791 | 1.901371106161229
gi|150373053 | |dbj|BAF66313.1| conserved hypothetical protein | 58.77666341710955 | 5.978989194238635 | 14.42892327419706 | 2.024304643128702 | 0.000261752301958287 | 0.2454872807563433
gi|150373071 | |dbj|BAF66331.1| siderophore compound ABC transporter binding protein | 5.885697796586857 | 0.6812316100170546 | 1.976912634406712 | 0.1102335540971559 | 0.000605163580941903 | 0.3358841555801817
[NAME] | |dbj|BAF66438.1| coagulase precursor | 26.26178222183988 | 4.318704365187022 | 8.281392402765107 | 1.941015956493144 | 0.00276571731393625 | 0.3153400760393983
gi|150373261 | |dbj|BAF66521.1| 5'-nucleotidase | 149.8768466988262 | 14.40239550338503 | 92.99979200600076 | 1.537317682948639 | 0.002441223003876969 | 0.6205080641500387
gi|150373274 | |dbj|BAF66534.1| truncated triacylglycerol lipase precursor | 45.24673826577817 | 3.925565875471095 | 36.47703976054895 | 2.207137873374365 | 0.02797024007288725 | 0.806180537175603
gi|150373376 | |dbj|BAF66636.1| conserved hypothetical protein | 9.346332891526425 | 1.857691682709687 | 3.592391837753897 | 0.9676673923899244 | 0.008918431175519027 | 0.3843637798318561
gi|150373487 | |dbj|BAF66747.1| cysteine synthase homolog | 6.159137975002333 | 0.9695768249187384 | 0.3253826277082091 | 0.5635792430908869 | 0.0008402733694892556 | 0.05282924802607394
gi|150373597 | |dbj|BAF66857.1| conserved hypothetical protein | 137.860578561903 | 26.61380552201219 | 55.95814602858649 | 10.42007023290557 | 0.007687421779112076 | 0.4059038966201626
gi|150373646 | |dbj|BAF66906.1| secretory antigen SsaA-like protein | 11.78163967088856 | 1.8330174621412 | 5.243484595009966 | 1.399821479178659 | 0.007986388234029645 | 0.4450555900097825
gi|150373667 | |dbj|BAF66927.1| MarR family regulatory protein | 3.499973332839222 | 1.194758253979818 | 0.6270228861438284 | 1.086035496309586 | 0.0368617902062471 | 0.1791507610245646
gi|150373753 | |dbj|BAF67013.1| glyceraldehyde 3-phosphate dehydrogenase 1 | 19.74204781390179 | 2.849447468342935 | 9.125645506563188 | 2.695995893578098 | 0.009394482700459368 | 0.4622441193834597
gi|150373755 | |dbj|BAF67015.1| triosephosphate isomerase | 8.404721496661603 | 0.9275064588770034 | 1.338018563626589 | 0.6578616848602628 | 0.0004223643088019027 | 0.159198441513863
gi|150373772 | |dbj|BAF67032.1| thermonuclease precursor | 24.11015969860807 | 1.756299820770496 | 15.76781633670852 | 3.654913237854413 | 0.02351534752173183 | 0.6539905390016487
gi|150373934 | |dbj|BAF67194.1| bifunctional autolysin precursor | 58.25367358766186 | 3.567951050750358 | 14.766614335984 | 1.022304752924952 | 3.48079441366882e-05 | 0.253488122320093
gi|150374052 | |dbj|BAF67312.1| iron-regulated heme-iron binding protein IsdB | 15.32599168654074 | 3.729181719600218 | 1.362198182341613 | 1.614860373931744 | 0.00399955345619749 | 0.08888156865815694
gi|150374053 | |dbj|BAF67313.1| iron-regulated heme-iron binding protein IsdA | 38.10665065801136 | 3.16521531965902 | 10.43948445147475 | 2.460093073415632 | 0.0002806221150005842 | 0.2739543956556048
gi|150374055 | |dbj|BAF67315.1| iron-transporting membrane protein | 3.863972137728565 | 0.66891695995972 | 0.3495622464232329 | 0.6054595712129515 | 0.002515981960044459 | 0.09046707221567156
gi|150374056 | |dbj|BAF67316.1| iron compound ABC transporter | 5.531943069412357 | 0.5727949060198589 | 0 | 0 | 7.483723492994455e-05 | 0
gi|150374085 | |dbj|BAF67345.1| alpha-hemolysin precursor | 45.73379222927978 | 4.221752977801612 | 28.46123681286815 | 4.712360435306467 | 0.009113916098264709 | 0.6223240065066514
gi|150374229 | |dbj|BAF67489.1| glutamine synthetase | 4.257065102802721 | 1.671711340274768 | 0.6270228861438284 | 1.086035496309586 | 0.03438358797414553 | 0.1472899453031657
gi|150374262 | |dbj|BAF67522.1| conserved hypothetical protein | 9.6197730699419 | 1.410959035470075 | 3.604263022390192 | 0.4031571138930475 | 0.002078216551778587 | 0.3746723541381793
gi|150374616 | |dbj|BAF67876.1| universal stress protein family protein | 4.491167043318541 | 0.536269170264799 | 0 | 0 | 0.0001313309280728547 | 0
gi|150374619 | |dbj|BAF67879.1| thiol peroxidase | 1.89182879448477 | 0.7602087929811997 | 0 | 0 | 0.01254286431481676 | 0
gi|150374636 | |dbj|BAF67896.1| haptoglobin-binding surface anchored protein | 1.548318145025112 | 0.8703527607371793 | 0 | 0 | 0.03688707619295939 | 0
gi|150374730 | |dbj|BAF67990.1| leukocidin LukD precursor | 56.35160071546226 | 3.938049367428194 | 17.28701431463805 | 5.416027263118266 | 0.000539881120851645 | 0.3067705991516702
gi|150374731 | |dbj|BAF67991.1| [NAME] precursor | 52.55085734301662 | 2.683531194178752 | 20.84199270205185 | 3.749171682479882 | 0.0002844996586125813 | 0.3966061403339122
gi|150374859 | |dbj|BAF68119.1| staphopain thiol proteinase | 7.837352984400968 | 1.282924791339154 | 0.674944874131442 | 0.5856435850839142 | 0.0009212287750520909 | 0.08611898372764565
gi|150374889 | |dbj|BAF68149.1| chemotaxis-inhibiting protein CHIPS | 168.7110543853307 | 20.02213581036842 | 107.5993352581918 | 9.467312941273757 | 0.008780437325170334 | 0.6377728812745032
[NAME] | |dbj|BAF68199.1| leukocidin/hemolysin toxin family F subunit | 99.77481635880598 | 13.99899613881479 | 33.11331207564317 | 3.438350077399402 | 0.001317776216997702 | 0.3318804612635164
gi|150374940 | |dbj|BAF68200.1| leukocidin/hemolysin toxin family S subunit | 211.6233624996437 | 13.72775028751362 | 87.38256554585253 | 2.240961955546785 | 0.0001018807046683756 | 0.4129154953106828
gi|150374943 | |dbj|BAF68203.1| iron compound ABC transporter | 6.622301411120671 | 3.232591349293182 | 0.6388940707801233 | 0.553584958758819 | 0.03418533814791414 | 0.09647613890048011
gi|150375055 | |dbj|BAF68315.1| conserved hypothetical protein | 4.904748163822381 | 0.5676930083475408 | 2.326474880829946 | 0.7106746222185241 | 0.007988535830245459 | 0.4743311589349515
gi|150375098 | |dbj|BAF68358.1| alkaline shock protein 23 | 8.758476223836103 | 0.4472551990297725 | 0.9405343292157426 | 1.629053244464379 | 0.001314107578258073 | 0.1073856119693615
gi|150375132 | |dbj|BAF68392.1| 50S ribosomal protein [NAME] | 6.319767072520382 | 2.834397637013697 | 1.30196776027527 | 0.502825873535472 | 0.03919600231237795 | 0.2060151498203926
gi|150375140 | |dbj|BAF68400.1| 30S ribosomal protein S13 | 1.961899265528952 | 0.2270772033390143 | 0.6388940707801233 | 0.553584958758819 | 0.01862238163051892 | 0.3256508027734388
gi|150375145 | |dbj|BAF68405.1| 50S ribosomal protein L15 | 4.571481592077565 | 1.660729246694703 | 1.326147378990294 | 1.15355844971228 | 0.04982449563957396 | 0.2900913745969194
gi|150375159 | |dbj|BAF68419.1| 50S ribosomal protein L22 | 4.824433615063357 | 1.519438161322635 | 1.651530006698503 | 0.5948131668287505 | 0.0280955140651175 | 0.3423261958754955
gi|150375327 | |dbj|BAF68587.1| 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 13.03602948206851 | 0.9913997835413987 | 0 | 0 | 2.201716253622898e-05 | 0
gi|150375329 | |dbj|BAF68589.1| immunoglobulin G-binding protein Sbi | 38.43991722975618 | 4.342079054934936 | 24.2906185758429 | 5.359076884240311 | 0.02373136823285078 | 0.6319113131970959
gi|150375330 | |dbj|BAF68590.1| gamma-hemolysin component A | 131.6436156041616 | 5.740128090322434 | 78.39942515358636 | 17.62879310121779 | 0.007628375250673041 | 0.5955429345645223
gi|150375331 | |dbj|BAF68591.1| gamma-hemolysin component C | 141.1677896027163 | 3.737965718702496 | 46.43113194129202 | 19.3868426945962 | 0.001144912067152144 | 0.3289074092040511
gi|150375332 | |dbj|BAF68592.1| gamma hemolysin | 126.7543151508556 | 5.904264868351501 | 58.12417401695053 | 13.9131678120509 | 0.001412425692401073 | 0.4585577536178907
gi|150375376 | |dbj|BAF68636.1| oligopeptide permease | 5.825871403257518 | 0.6180450533833425 | 1.30196776027527 | 0.502825873535472 | 0.0005995005357786527 | 0.2234803465705197
gi|150375460 | |dbj|BAF68720.1| ATP-dependent [NAME] protease | 1.678215009398634 | 0.7170024406274266 | 0 | 0 | 0.0154243100549062 | 0
gi|150375511 | [NAME] dehydrogenase 2 | 22.94469044094227 | 4.586156549167704 | 6.859401047799586 | 2.315030351767541 | 0.005605276592154722 | 0.2989537411914585
gi|150375515 | |dbj|BAF68775.1| fructose-bisphosphate aldolase class-I | 2.589094171118928 | 0.4855321678910659 | 0 | 0 | 0.0007638170125578889 | 0
gi|150375555 | |dbj|BAF68815.1| N-acetylmuramoyl-L-alanine amidase domain protein | 17.67594347223055 | 5.222559409763266 | 4.255465527249044 | 1.358399308057855 | 0.01257036941194894 | 0.2407489893783895
gi|150375581 | |dbj|BAF68841.1| lipase precursor | 25.25514080084418 | 1.434799114603606 | 13.19949437006686 | 1.304260888902106 | 0.0004216004210509536 | 0.5226458436385221
gi|151220271 | |ref|YP_001331094.1| siderophore compound ABC transporter binding protein | 5.885697796586857 | 0.6812316100170546 | 1.976912634406712 | 0.1102335540971559 | 0.000605163580941903 | 0.3358841555801817
gi|151222321 | |ref|YP_001333143.1| truncated MHC class II analog protein | 80.4324661041432 | 16.16310932273561 | 18.57618549273068 | 6.269168406764365 | 0.003483026092824014 | 0.2309538224114427
1 Protein ID in NCBI for S. aureus strain Newman.
2 Protein function based on BLAST searches for S. aureus strain Newman.
3 Mean of the number of spectra detected in the three samples analyzed for this condition.
4 Standard deviation among the number of the spectra detected in the three samples analyzed for this condition.
5 p-value as obtained by applying Student's t-test.
6 Ratio of the mean of number of spectra detected in the presence of hemin to that in its absence.