Spreadsheet: 1f77a376-dc7c-4e58-ba23-50a2072c8f3a
Sheet: Sheet1

Pathways Identified Using the Proposed Approach | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10
[NAME] | size | p-value |  | [NAME] | [NAME] | [NAME] | [NAME]
Glutamate metabolism | 5 | 2.22044604925031e-16 |  | 2.46974673398298e-06 | 3.33376711457659e-05 | 1.39756626656021e-05 | 1.30242352535342e-05 |  | [NAME]
Amyotrophic lateral sclerosis (ALS) | 6 | 5.55111512312578e-15 |  | 3.0898199502515e-05 | 5.00052990362988e-05 | 2.6062248849851e-05 | 1.01874284833153e-05 |  | size | Number of genes in each pathway
Colorectal cancer | 19 | 2.26263452418607e-13 |  | 8.05867496439562e-05 | 9.34199751294317e-05 | 3.11192818634658e-05 | 9.49340228244181e-05 |  | p-value | Unadjusted p-value from meta analysis
Small cell lung cancer | 27 | 1.15396581179539e-12 |  | 0.000103555052175604 | 8.41776587532391e-05 | 9.63648133059654e-05 | 0.000155009490885745 |  | [NAME], [NAME], [NAME], [NAME]: p-values from each dataset
Streptomycin biosynthesis | 2 | 1.94855243051961e-12 |  | 0.000195638380204831 | 8.40217844825693e-05 | 8.72969021092854e-05 | 0.000160390271876006
Cell cycle | 36 | 3.10174108619776e-12 |  | 0.000357022155359036 | 1.26206322983779e-05 | 0.00018083341664889 | 0.000468563280865663
Prion disease | 4 | 3.37463390565063e-12 |  | 0.000121331389512036 | 0.000124432596195804 | 0.000173043343634576 | 0.000160198859038487
Renin-angiotensin system | 2 | 8.9912521872293e-12 |  | 0.000100448892561481 | 0.000514261034180856 | 5.70253523834036e-05 | 0.00041389912590197
Nicotinate and nicotinamide metabolism | 5 | 1.13254960965037e-11 |  | 0.00036196695778473 | 0.000310420543959735 | 4.04301437955644e-05 | 0.000345399674591129
Circadian rhythm | 2 | 4.23893142809106e-11 |  | 0.00043475755252767 | 0.000256730615258047 | 0.000144025993916373 | 0.000414388270540318
Glycerophospholipid metabolism | 14 | 4.35615987726123e-11 |  | 0.000351897305409866 | 0.000486562092200528 | 0.000144817781171355 | 0.000276823590394026
Prostate cancer | 20 | 1.21393783913959e-10 |  | 9.08419318194745e-05 | 0.000358344942975867 | 0.00111286269030276 | 0.000584778601365794
Apoptosis | 27 | 4.67419214444931e-10 |  | 0.000234419542181302 | 0.000311019948757997 | 0.00179014281773874 | 0.000719202506148593
Oxidative phosphorylation | 15 | 7.32049199037021e-10 |  | 0.000921791035245346 | 0.000780002451858125 | 0.000240141775778594 | 0.000893660348325878
Synthesis and degradation of ketone bodies | 2 | 8.75143957301816e-10 |  | 0.00060113447256405 | 0.000773420449110572 | 0.000970812362021535 | 0.000416729043725215
D-Glutamine and D-glutamate metabolism | 2 | 1.78046888343886e-09 |  | 0.000756801869368114 | 0.000733983753690888 | 0.00100739695040343 | 0.00074006030877984
Focal adhesion | 49 | 2.07206174440699e-09 |  | 0.000146535276927278 | 0.00168602069376241 | 0.0015337738856432 | 0.0012938845931443
Dentatorubropallidoluysian atrophy (DRPLA) | 5 | 2.23875529226092e-09 |  | 0.000421158709018175 | 0.000664643308365804 | 0.00121689911178598 | 0.0015689160476999
Renal cell carcinoma | 17 | 5.05576169818056e-09 |  | 0.00132544781898959 | 0.0033448829502942 | 0.000466416131448371 | 0.000641465892388532
[NAME] | 10 | 5.55592749584832e-09 |  | 0.000304216588165181 | 0.00197253355173685 | 0.000657954594251655 | 0.00373338153274499
Cell Communication | 29 | 1.81494798079385e-08 |  | 0.00217179622614918 | 0.0012788137274969 | 0.00188883925838895 | 0.00106014083885914
Methionine metabolism | 6 | 2.69025968169245e-08 |  | 0.00206349784539311 | 0.00123240313524861 | 0.00191476052848761 | 0.00177916471064213
Biotin metabolism | 4 | 3.55043862088067e-08 |  | 0.00335823721243702 | 0.00110272981672726 | 0.000767827884462414 | 0.0041666025048241
Epithelial cell signaling in Helicobacter pylori infection | 13 | 4.35359120976031e-08 |  | 0.0052278353418446 | 0.000400992845436361 | 0.00131593523703939 | 0.00540741301440973
Ubiquitin mediated proteolysis | 7 | 4.37705890421469e-08 |  | 0.00219495121300563 | 0.00213492473123896 | 0.00254020976368083 | 0.00126079583206642
Adherens junction | 18 | 4.53977007097706e-08 |  | 0.00403162220257225 | 0.00318933543369908 | 0.00149048872733002 | 0.000816081892872166
Jak-STAT signaling pathway | 23 | 5.88144559721115e-08 |  | 0.000364739060753216 | 0.00487415413903425 | 0.00506371117504197 | 0.00232878055150635
VEGF signaling pathway | 17 | 5.8942766112402e-08 |  | 0.00222253668149994 | 0.00252203620749161 | 0.0021681865227804 | 0.00172923419322556
Ribosome | 7 | 7.21298619721367e-08 |  | 0.00311371770350392 | 0.00226181706100213 | 0.00490124285205769 | 0.000765343401665638
Pathogenic Escherichia coli infection - EHEC | 7 | 1.67723195554359e-07 |  | 0.00927136041344305 | 0.000741198572058281 | 0.000823873838217235 | 0.0121761148563082
Cholera - Infection | 6 | 4.16471346742497e-07 |  | 0.00404048392804081 | 0.0049328740476219 | 0.00122382285101691 | 0.00799316633101051
Pathogenic Escherichia coli infection - EPEC | 7 | 4.86201933824759e-07 |  | 0.0100814530566801 | 0.00951692709900188 | 0.000696448682335068 | 0.00348498099955851
[NAME] transendothelial migration | 20 | 5.12485303971744e-07 |  | 0.0107183024897548 | 0.00139673064576277 | 0.00153055658526429 | 0.0107963033740289
Porphyrin and chlorophyll metabolism | 9 | 5.37121196408918e-07 |  | 0.0011486352629777 | 0.00569308712224424 | 0.0063510542046307 | 0.00628650223715554
Butanoate metabolism | 9 | 1.75306518546137e-06 |  | 0.000871790658519619 | 0.0132037872478969 | 0.00404936561892887 | 0.0219366217519262
Cytokine-cytokine receptor interaction | 43 | 2.47843245360091e-06 |  | 0.00518974385374207 | 0.010124551923586 | 0.00758275494022736 | 0.00383669271390803
Galactose metabolism | 8 | 4.12096398449968e-06 |  | 0.00236162964812871 | 0.00804653718230646 | 0.0093334591492349 | 0.0155906045134167
MAPK signaling pathway | 51 | 8.02759859797053e-06 |  | 0.00846863706570143 | 0.0133435761656486 | 0.00538565481018705 | 0.00992823608677199
Linoleic acid metabolism | 7 | 9.07000704675198e-06 |  | 0.0069506663550727 | 0.017856049739896 | 0.0203886621721959 | 0.00275675211347313
Insulin signaling pathway | 32 | 1.16408653716427e-05 |  | 0.00550240688950282 | 0.0804900654749353 | 0.00645443772825144 | 0.00327525357578478
ABC transporters - General | 6 | 1.89321829012767e-05 |  | 0.0125093363701827 | 0.0169005449449176 | 0.0081519448362789 | 0.00966219908285728
Type II diabetes mellitus | 7 | 2.05221516973442e-05 |  | 0.0156476774312922 | 0.00153347382953648 | 0.0295349989703628 | 0.0258588067409739
Hematopoietic cell lineage | 30 | 2.79515535518415e-05 |  | 0.011034426336316 | 0.0128646338447799 | 0.0282172171084944 | 0.00660941597570094
mTOR signaling pathway | 14 | 3.74367162385703e-05 |  | 0.00220063228058502 | 0.021715305254272 | 0.0275966173870356 | 0.0284634096550017
Pyrimidine metabolism | 21 | 5.4891340575347e-05 |  | 0.0072030652343128 | 0.0084781219785207 | 0.0336234574489427 | 0.0289385691972334
Caprolactam degradation | 2 | 7.81478573181893e-05 |  | 0.00769650426456613 | 0.0618914895612325 | 0.0101549372587088 | 0.0188100061042131
Long-term potentiation | 13 | 8.09112132712508e-05 |  | 0.00448730758902435 | 0.00433671766377542 | 0.0753687362684619 | 0.064700403176458
Hedgehog signaling pathway | 11 | 8.24844751567966e-05 |  | 0.0347849563612739 | 0.0106103568783478 | 0.0078307970465391 | 0.0336076471339506
Lysine degradation | 13 | 9.43509590889402e-05 |  | 0.0496699024524129 | 0.00607444447292369 | 0.00517580499186859 | 0.0731987606428142
[NAME], leucine and isoleucine biosynthesis | 2 | 9.77434833584478e-05 |  | 0.0292833962588286 | 0.039945668724508 | 0.0124048554779706 | 0.00822256337472642
Olfactory transduction | 3 | 0.000217261486495479 |  | 0.0508415457387016 | 0.0374704992496646 | 0.00685504373764425 | 0.0242277573077377
Fructose and mannose metabolism | 7 | 0.000219092591350001 |  | 0.0226939780934039 | 0.0196819890657853 | 0.0188751130311072 | 0.0379177497704967
Glutathione metabolism | 14 | 0.000232651091527147 |  | 0.0258332573731835 | 0.0257697676197035 | 0.0176963274435421 | 0.0292152900352052
One carbon pool by folate | 2 | 0.00030951730823281 |  | 0.0389235814076743 | 0.0319156630629097 | 0.0101121311663886 | 0.038964590215828
Cysteine metabolism | 2 | 0.000329983599947625 |  | 0.027471296547702 | 0.0258136920067656 | 0.0423729172978136 | 0.0176329840724149
Natural killer cell mediated cytotoxicity | 26 | 0.00045494230333909 |  | 0.0314729579209581 | 0.0356851947581152 | 0.0179251440435495 | 0.039218310218158
Phosphatidylinositol signaling system | 15 | 0.000491734332051075 |  | 0.046831146997559 | 0.0253577599548992 | 0.0668353205583025 | 0.0109608066857584
[NAME], leucine and isoleucine degradation | 15 | 0.000634943500626428 |  | 0.0427958051957232 | 0.014195939333979 | 0.0603203368975559 | 0.0326862346709765
[NAME] metabolism | 1 | 0.000636718327014396 |  | 0.0538230708025389 | 0.0107744752269492 | 0.0637007757107572 | 0.0325391124032877
Pyruvate metabolism | 10 | 0.000687243986689956 |  | 0.0130094065580734 | 0.049653981583078 | 0.045833273948557 | 0.0446856803923662
Retinol metabolism | 1 | 0.000692960717007751 |  | 0.0108422983851584 | 0.0526712059300471 | 0.0496391028389368 | 0.0471589641520703
Wnt signaling pathway | 25 | 0.000697038990879251 |  | 0.0935864024303966 | 0.00271916410324848 | 0.0554827872533605 | 0.095384993430963
Toll-like receptor signaling pathway | 16 | 0.00092236437952642 |  | 0.0255484715232554 | 0.0241723228961859 | 0.0398411576221719 | 0.0779257089716622
Glyoxylate and dicarboxylate metabolism | 2 | 0.0011990963971491 |  | 0.052925160284435 | 0.0349329796780423 | 0.11057357047626 | 0.0130845476713464
Complement and coagulation cascades | 23 | 0.00121521464513685 |  | 0.104710067585091 | 0.0319486137655457 | 0.0116061561509436 | 0.0700749273666508
Folate biosynthesis | 5 | 0.00162090567704598 |  | 0.0386584628660684 | 0.0491645542937693 | 0.0620964522885139 | 0.0333140963962275
Gap junction | 11 | 0.00191648205996886 |  | 0.00666175895341745 | 0.108030576485143 | 0.0722339253501174 | 0.0938099874766242
Carbon fixation | 4 | 0.00261826600022419 |  | 0.0601751859263201 | 0.12985003376952 | 0.0591314027000995 | 0.0158067423410369
Ether lipid metabolism | 5 | 0.00269376059873594 |  | 0.0720604814004467 | 0.194000312687694 | 0.00804419797273917 | 0.0673899962855498
DNA polymerase | 5 | 0.00315001655244074 |  | 0.0759840809639532 | 0.0103493302738099 | 0.0742793631336668 | 0.159114838451777
Sphingolipid metabolism | 4 | 0.00321173210067127 |  | 0.0695137828395837 | 0.130653293911801 | 0.0079936624452896 | 0.131309891668795
Pantothenate and CoA biosynthesis | 5 | 0.00349988651031474 |  | 0.0225083026052855 | 0.109823386142918 | 0.092297995189745 | 0.0467615134483098
Inositol phosphate metabolism | 10 | 0.00368005313303732 |  | 0.0547802342230101 | 0.0511471676578796 | 0.0659938842818217 | 0.0616297385534639
Bisphenol A degradation | 2 | 0.0040589940110034 |  | 0.0419910433628271 | 0.056499329297288 | 0.084809402392933 | 0.0644336051693154
Proteasome | 6 | 0.00432471191755135 |  | 0.0894643619944421 | 0.0862642247066366 | 0.0325480799816919 | 0.0561163922177617
N-Glycan degradation | 4 | 0.00526895177077147 |  | 0.117675713451176 | 0.0351045401417248 | 0.0452788870573796 | 0.0979113501948404
Ascorbate and aldarate metabolism | 3 | 0.00548780983377295 |  | 0.0811760676768633 | 0.0826567964731886 | 0.0723201156042287 | 0.0398418383294366
Aminophosphonate metabolism | 1 | 0.00551221130543078 |  | 0.113551215648411 | 0.036638718533859 | 0.0609193180210244 | 0.0767334505554764
Alzheimer's disease | 9 | 0.00689550224267921 |  | 0.0273056553864375 | 0.211788704015248 | 0.119313893029531 | 0.0380286341126426
TGF-beta signaling pathway | 25 | 0.00691426702577014 |  | 0.25238402920801 | 0.0850061485201718 | 0.15096281189896 | 0.00813131211061457
Androgen and estrogen metabolism | 4 | 0.00699989633020914 |  | 0.153142543182328 | 0.0842950664348302 | 0.0197473633468602 | 0.105031480015272
Nitrogen metabolism | 6 | 0.0075109380643974 |  | 0.0640236264597622 | 0.105055375057502 | 0.0818362220052987 | 0.0534830302558673
Pancreatic cancer | 21 | 0.00781230219484186 |  | 0.00947538127961697 | 0.157357885268875 | 0.141721617660866 | 0.146908305867239
Bile acid biosynthesis | 6 | 0.0107436987385977 |  | 0.108916890892876 | 0.0715609418129975 | 0.0805265908625157 | 0.0762626359626237
ECM-receptor interaction | 32 | 0.0117635550053562 |  | 0.125027065611655 | 0.117736756790298 | 0.0168993530314597 | 0.217889957221744
Dorso-ventral axis formation | 3 | 0.0117920800011965 |  | 0.0262428734525077 | 0.116048723884541 | 0.116058359163786 | 0.153865210466859
Aminosugars metabolism | 5 | 0.0125410024183898 |  | 0.073745438036961 | 0.106631699442093 | 0.0636951515719205 | 0.118178453806476
Tight junction | 22 | 0.0126015123188099 |  | 0.356856456552374 | 0.0363961662655937 | 0.201617067440314 | 0.022754672141178
Arginine and proline metabolism | 7 | 0.0127754893594308 |  | 0.0159046209080551 | 0.169102024726466 | 0.149530598551289 | 0.150992417293555
Atrazine degradation | 1 | 0.0130690811927217 |  | 0.0172296700343679 | 0.087817471850676 | 0.192391548116026 | 0.215243433351371
Pentose phosphate pathway | 8 | 0.0140522759952706 |  | 0.134953666994447 | 0.0692767118022764 | 0.133955581389312 | 0.0553107604698138
Maturity onset diabetes of the young | 2 | 0.0150016179938355 |  | 0.0672065497117003 | 0.117375815421876 | 0.0933540618907348 | 0.102995309204983
Huntington's disease | 10 | 0.0154262674740134 |  | 0.220250661375469 | 0.0436098924744387 | 0.135671495343087 | 0.0605078131115636
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | 1 | 0.0155592891950749 |  | 0.0760651934962032 | 0.0550487297771222 | 0.0401591743630048 | 0.474542889074606
Glycolysis / Gluconeogenesis | 15 | 0.0183111891863283 |  | 0.144381670483301 | 0.0316321861180962 | 0.408902825372475 | 0.053657231901812
PPAR signaling pathway | 16 | 0.0189774398823197 |  | 0.123996292193387 | 0.103764788912337 | 0.119514067675332 | 0.0685216872422897