Spreadsheet: 361e6057-998a-4efd-9715-5108a746877c
Sheet: Sheet1

Seed | Description | [NAME] GeneID | Seed'sType in ResNet7 | Regulation of up- or down- regulated genes | Num evidences in top 100 | Evidence datasets | Sum of aggregated dataset ranks | Mean rank | Rank from SNEA of reference dataset | Connectivity | Comment | Related to DMD in PubMed | Related to DMD in PubMed (Human) | Related to DMD in PubMed (mdx mice)
ADIPOQ | adiponectin, C1Q and collagen domain containing | 9370 | Protein | negative | 0 | reference | NA | NA | 6 | 3 |  | - | - | -
ADRB3 | adrenergic, beta-3-, receptor | 155 | Protein | negative | 6 | no214 no1956 no2855 no3027 no563 all | 68 | 11.33333 | NA | 1 |  | - | - | -
AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 183 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 126 | 21 | NA | 28 |  | + | + | +
alkaline phosphohydrolase | alkaline phosphohydrolase | NA | Functional class | positive | 6 | no214 no1956 no2855 no3027 no563 all | 256 | 42.66667 | NA | 2 |  | - | - | -
allergen | allergen | NA | Functional class | positive | 0 | reference | NA | NA | 31 | 4 |  | - | - | -
AML1-ETO | AML1-ETO fusion | NA | Functional class | positive | 5 | [NAME] no2855 no3027 no563 all reference | 77 | 15.4 | 22 | 5 |  | - | - | -
AMPK | 5' AMP-activated protein kinase | NA | Functional class | negative | 6 | no214 no1956 no2855 no3027 no563 all | 66 | 11 | 12 | 4 |  | + | - | +
angiotensin II receptor | angiotensin II receptor | NA | Functional class | positive | 6 | no214 no1956 no2855 no3027 no563 all | 42 | 7 | NA | 3 |  | + | + | +
ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | 471 | Protein | negative | 6 | no214 no1956 no2855 no3027 no563 all | 99 | 16.5 | NA | 5 | false positive - In ResNet7 database ATIC has a synonym AICAR, which coincide with a name of a chemical compound, that is widely used to modulate AMPK activity. Most of the relations, that were used in SNEA, apply to AICAR but not ATIC. | false positive | false positive | -
BMP2 | bone morphogenetic protein 2 | 650 | Protein | positive | 5 | [NAME] no2855 no3027 no563 all reference | 112 | 22.4 | 12 | 15 |  | - | - | -
CAMP | cathelicidin antimicrobial peptide | 820 | Protein | positive | 1 | no3027 reference | 62 | 62 | 18 | 4 |  | - | - | -
CCAAT factors | CCAAT-enhancer-binding proteins | NA | Functional class | negative | 0 | reference | NA | NA | 13 | 7 |  | - | - | -
CCL2 | chemokine (C-C motif) ligand 2 | 6347 | Protein | positive | 0 | reference | NA | NA | 4 | 4 |  | + | - | +
CCR7 | chemokine (C-C motif) receptor 7 | 1236 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 169 | 28.16667 | NA | 1 |  | - | - | -
CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, [NAME]) | 1027 | Protein | positive | 1 | no1956 reference | 77 | 77 | 32 | 3 |  | - | - | -
CIITA | class II, major histocompatibility complex, transactivator | 4261 | Protein | positive | 1 | no563 reference | 86 | 86 | 2 | 6 |  | - | - | -
CMA1 | chymase 1, mast cell | 1215 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 227 | 37.83333 | NA | 2 |  | + | - | +
collagen type I | collagen type I | NA | Complex | positive | 6 | no214 no1956 no2855 no3027 no563 all | 228 | 38 | 5 | 9 |  | + | - | +
CSF1 | colony stimulating factor 1 (macrophage) | 1435 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 43 | 7.166667 | 33 | 14 |  | + | - | +
CSH1 | chorionic somatomammotropin hormone 1 (placental lactogen) | 1442 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 152 | 25.33333 | NA | 0 |  | - | - | -
CTCF | CCCTC-binding factor (zinc finger protein) | 10664 | Protein | negative | 6 | no214 no1956 no2855 no3027 no563 all | 179 | 29.83333 | NA | 2 |  | - | - | -
CTGF | connective tissue growth factor | 1490 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 6 | 1 | 1 | 15 |  | + | + | +
CTSL1 | cathepsin L1 | 1514 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 356 | 59.33333 | NA | 2 | false positive - explained by the fact that relation “expression” used for SNEA doesn’t equal “gene expression”, but includes broader spectrum of influences, in example proteolytic cleavage as a stage of protein maturation. | false positive | false positive | -
CXCL2 | chemokine (C-X-C motif) ligand 2 | 2920 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 144 | 24 | NA | 2 |  | - | - | -
ESRRA | estrogen-related receptor alpha | 2101 | Protein | negative | 4 | [NAME] no2855 no563 all reference | 87 | 21.75 | 4 | 1 |  | - | - | -
FGF2 | fibroblast growth factor 2 (basic) | 2247 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 15 | 2.5 | NA | 35 |  | + | + | +
FOXI1 | forkhead box I1 | 2299 | Protein | negative | 6 | no214 no1956 no2855 no3027 no563 all | 116 | 19.33333 | NA | 1 |  | - | - | -
GCG | [NAME] | 2641 | Protein | negative | 4 | [NAME] no2855 no3027 all reference | 146 | 36.5 | 9 | 3 |  | - | - | -
GF | Growth Factors | NA | Functional class | positive | 4 | no2855 no3027 no563 all reference | 140 | 35 | 14 | 32 |  | + | - | +
GH1 | growth hormone 1 | 2688 | Protein | negative | 5 | [NAME] no2855 no3027 no563 all reference | 93 | 18.6 | 2 | 8 |  | - | - | -
GJA1 | gap junction protein, alpha 1, 43kDa | 2697 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 189 | 31.5 | 9 | 3 |  | + | - | +
HDAC1 | histone deacetylase 1 | 3065 | Protein | negative | 6 | no214 no1956 no2855 no3027 no563 all | 261 | 43.5 | NA | 7 |  | + | - | +
histone deacetylase inhibitor | histone deacetylase inhibitor | NA | Functional class | positive | 0 | reference | NA | NA | 7 | 5 |  | + | - | +
IFNG | interferon, gamma | 3458 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 37 | 6.166667 | 11 | 52 |  | + | - | +
IL13 | interleukin 13 | 3596 | Protein | positive | 0 | reference | NA | NA | 20 | 8 |  | - | - | -
IL4 | interleukin 4 | 3565 | Protein | positive | 0 | reference | NA | NA | 15 | 25 |  | - | - | -
IL6 | interleukin 6 (interferon, beta 2) | 3569 | Protein | positive | 0 | reference | NA | NA | 34 | 27 |  | + | + | +
IL6R | interleukin 6 receptor | 3570 | Protein | positive | 0 | reference | NA | NA | 30 | 2 |  | - | - | -
ING4 | inhibitor of growth family, member 4 | 51147 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 296 | 49.33333 | NA | 3 |  | - | - | -
INS | insulin | 3630 | Protein | negative | 0 | reference | NA | NA | 7 | 30 |  | - | - | -
IRF1 | interferon regulatory factor 1 | 3659 | Protein | positive | 0 | reference | NA | NA | 26 | 7 |  | - | - | -
LEP | [NAME] | 3952 | Protein | negative | 0 | reference | NA | NA | 10 | 14 |  | + | - | +
LPL | [NAME] | 4023 | Protein | positive | 0 | reference | NA | NA | 6 | 1 |  | - | - | -
MAPK | MAPK | NA | Functional class | positive | 0 | reference | NA | NA | 17 | 28 |  | + | - | +
MAPK3 | mitogen-activated protein kinase 3 | 5595 | Protein | positive | 0 | reference | NA | NA | 21 | 21 |  | - | - | -
MEF2C | myocyte enhancer factor 2C | 4208 | Protein | negative | 5 | [NAME] no2855 no3027 no563 all reference | 86 | 17.2 | 11 | 2 |  | + | - | +
MIRN29C | microRNA 29c | 407026 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 192 | 32 | NA | 3 |  | - | - | -
muscle fiber | muscle fiber | NA | Complex | negative | 6 | no214 no1956 no2855 no3027 no563 all | 33 | 5.5 | NA | 6 |  | + | + | +
MYOD1 | myogenic differentiation 1 | 4654 | Protein | negative | 6 | no214 no1956 no2855 no3027 no563 all | 21 | 3.5 | 5 | 8 |  | + | + | +
MYOG | myogenin (myogenic factor 4) | 4656 | Protein | negative | 6 | no214 no1956 no2855 no3027 no563 all | 114 | 19 | NA | 5 |  | + | - | +
NF-kB | NF-kB | NA | Functional class | positive | 0 | reference | NA | NA | 27 | 39 |  | + | + | +
NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 7376 | Protein | negative | 0 | reference | NA | NA | 8 | 1 |  | - | - | -
NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 7376 | Protein | positive | 0 | reference | NA | NA | 8 | 1 |  | - | - | -
NR1H4 | nuclear receptor subfamily 1, group H, member 4 | 9971 | Protein | positive | 0 | reference | NA | NA | 13 | 6 |  | - | - | -
NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 4929 | Protein | positive | 0 | reference | NA | NA | 29 | 1 |  | - | - | -
PPARD | peroxisome proliferator-activated receptor delta | 5467 | Protein | negative | 6 | no214 no1956 no2855 no3027 no563 all | 360 | 60 | NA | 3 |  | - | - | -
PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 10891 | Protein | negative | 6 | no214 no1956 no2855 no3027 no563 all | 41 | 6.833333 | NA | 6 |  | + | + | +
[NAME] | [NAME], AMP-activated, alpha 2 catalytic subunit | 5563 | Protein | negative | 0 | reference | NA | NA | 14 | 0 |  | - | - | -
PTH | parathyroid hormone | 5741 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 209 | 34.83333 | NA | 7 |  | + | - | +
RHOA | ras homolog gene family, member A | 387 | Protein | positive | 2 | no1956 no563 reference | 164 | 82 | 23 | 9 |  | + | - | +
[NAME] | runt-related transcription factor 1 | 861 | Protein | positive | 0 | reference | NA | NA | 19 | 11 |  | - | - | -
RUNX2 | runt-related transcription factor 2 | 860 | Protein | positive | 5 | no214 no1956 no2855 no3027 all reference | 258 | 51.6 | 3 | 8 |  | + | - | +
SCXA | scleraxis homolog A | 333927 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 169 | 28.16667 | NA | 1 |  | - | - | -
SMAD | SMAD | NA | Functional class | positive | 6 | no214 no1956 no2855 no3027 no563 all | 413 | 68.83333 | NA | 13 |  | + | - | +
SMAD7 | [NAME] family member 7 | 4092 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 115 | 19.16667 | 10 | 5 |  | - | - | -
SREBF1 | sterol regulatory element binding transcription factor 1 | 6720 | Protein | negative | 4 | no214 no1956 no2855 no563 reference | 215 | 53.75 | 3 | 8 |  | - | - | -
SREBF2 | sterol regulatory element binding transcription factor 2 | 6721 | Protein | negative | 0 | reference | NA | NA | 1 | 1 |  | - | - | -
STAT1 | signal transducer and activator of transcription 1, 91kDa | 6772 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 275 | 45.83333 | NA | 12 |  | + | - | +
TGF family | TGF family | NA | Functional class | positive | 6 | no214 no1956 no2855 no3027 no563 all | 170 | 28.33333 | NA | 34 |  | + | + | +
TGFB1 | transforming growth factor, beta 1 | 7040 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 38 | 6.333333 | NA | 54 |  | + | + | +
TGFB2 | transforming growth factor, beta 2 | 7042 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 172 | 28.66667 | NA | 9 |  | + | + | -
TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | 4982 | Protein | positive | 1 | no1956 reference | 46 | 46 | 28 | 4 |  | - | - | -
TORC2 | mTOR Complex 2 | NA | Complex | negative | 6 | no214 no1956 no2855 no3027 no563 all | 31 | 5.166667 | NA | 2 |  | - | - | -
TWIST1 | twist homolog 1 (Drosophila) | 57 | Protein | positive | 2 | no214 no1956 reference | 155 | 77.5 | 25 | 4 |  | - | - | -
UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 7351 | Protein | negative | 6 | no214 no1956 no2855 no3027 no563 all | 124 | 20.66667 | NA | 1 |  | - | - | -
VTN | vitronectin | 7448 | Protein | positive | 5 | no214 no1956 no2855 no3027 all reference | 55 | 11 | 24 | 5 |  | - | - | -
[NAME] | zinc finger E-box binding homeobox 1 | 6935 | Protein | positive | 6 | no214 no1956 no2855 no3027 no563 all | 306 | 51 | NA | 3 |  | - | - | -
[NAME] | zinc finger homeobox 3 | 463 | Protein | positive | 2 | no214 no1956 reference | 144 | 72 | 16 | 1 |  | - | - | -