Spreadsheet: 25bb7e2e-a2b7-436b-92d5-e0204903293b
Sheet: Sheet1

Table S1. Comparison of the minimal bacterial gene set to NoAz. | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7
Function | Gene symbol | EC number | Product | NoAz | Noss | Avar | [NAME]
1.1. DNA metabolism
1.1.1. Basic replication machinery
 | dnaB | 3.6.1.- | replicative DNA helicase | Aazo_2896 | all0578 | Ava_0330 | Npun_F2831
 | dnaE | 2.7.7.7 | DNA polymerase III, alpha subunit | Aazo_4135 | all3578 | Ava_1603 | Npun_F4872
 | dnaG | 2.7.7.- | DNA primase | Aazo_3686 | all1323 | Ava_3790 | Npun_R3583
 | dnaN | 2.7.7.7 | DNA polymerase III, beta subunit | Aazo_2082 | [NAME] | Ava_0002 | Npun_R0034
 | dnaN | 2.7.7.7 | DNA polymerase III, beta subunit | Aazo_5292 (*) | alr7569 | Ava_C0075 | Npun_R0034
 | dnaQ | 2.7.7.7 | DNA polymerase III epsilon subunit | (-) | (-) | Ava_B0261 | (-)
 | dnaX | 2.7.7.7 | DNA polymerase III gamma and tau subunits | Aazo_4353 | alr4932 | Ava_2215 | Npun_F4123
 | dnaX | 2.7.7.7 | DNA polymerase III gamma and tau subunits | Aazo_5290 (*) | alr4932 | Ava_2215 | Npun_F4123
 | gyrA | 5.99.1.3 | DNA gyrase, A subunit | Aazo_0531 | all0860 | Ava_4464 | Npun_F0025
 | gyrA | 5.99.1.3 | DNA gyrase, A subunit | Aazo_2820 | all0441 | Ava_2854 | Npun_R6377
 | gyrB | 5.99.1.3 | DNA gyrase, B subunit | [NAME] | all5265 | Ava_2517 | Npun_F6373
 | holA | 2.7.7.7 | DNA polymerase III, delta subunit | Aazo_3538 | alr3444 | Ava_3469 | Npun_F4117
 | holB | 2.7.7.7 | DNA polymerase III, delta prime subunit | Aazo_3025 | all4705 | Ava_1963 | Npun_F6434
 | hupB |  | histone family protein DNA-binding protein | Aazo_0318 | asr3935 | Ava_1767 | Npun_F5010
 | lig | 6.5.1.2 | DNA ligase, NAD-dependent | Aazo_3950 | all1717 | Aazo_3950 | Npun_F0173
 | ssb |  | single-strand binding protein | Aazo_0865 | alr0088 | Aazo_0865 | Npun_F1842
 | ssb |  | single-strand binding protein | Aazo_5287 (*) | alr7579 | Ava_C0119 | (-)
1.1.2. DNA repair, restriction and modification
 | nth | 4.2.99.18 | endonuclease III | [NAME] | all3970 | Ava_1731 | Npun_F4036
 | polA | 2.7.7.7 | 5'-3' exonuclease domain of DNA polymerase I | Aazo_0136 | alr1254 | Ava_0581 | Npun_F6197
 | ung | 3.2.2.- | uracil-DNA glycosylase | Aazo_0465 (+) | (-) | (-) | (-)
1.2. RNA metabolism
1.2.1. Basic transcription machinery
 | deaD |  | ATP-dependent RNA helicase | Aazo_0442 | alr1223 | Ava_0642 | [NAME]
 | greA |  | transcription elongation factor | (-) | (-) | (-) | (-)
 | nusA |  | transcription elongation factor | Aazo_0597 | alr3829 | Ava_1870 | Npun_R5775
 | nusG |  | transcription antitermination protein | Aazo_1041 | alr5299 | Ava_2551 | Npun_F5850
 | rpoA | 2.7.7.6 | DNA-directed RNA polymerase subunit alpha | Aazo_2583 | [NAME] | Ava_0715 | [NAME]
 | rpoB | 2.7.7.6 | DNA-directed RNA polymerase subunit beta | Aazo_1016 | alr1594 | Ava_4207 | Npun_F4985
 | rpoC1 | 2.7.7.6 | DNA-directed RNA polymerase subunit gamma | Aazo_1015 | alr1595 | Ava_4208 | Npun_F4986
 | rpoC2 | 2.7.7.6 | DNA-directed RNA polymerase beta' subunit | Aazo_1014 | alr1596 | Ava_4209 | Npun_F4987
 | rpoD |  | RpoD family RNA polymerase sigma factor | Aazo_2817 | all5263 | Ava_1410 | Npun_F6374
1.2.2. Translation
1.2.2.1. Aminoacyl-tRNA synthesis
 | alaS | 6.1.1.7 | alanyl-tRNA synthetase | Aazo_3088 | alr2418 | Ava_0226 | Npun_F0562
 | argS | 6.1.1.19 | arginyl-tRNA synthetase | Aazo_2060 | all3717 | Ava_3561 | Npun_R4006
 | [NAME] | 6.1.1.22 | asparaginyl-tRNA synthetase | Aazo_3649 | alr3658 | Ava_3630 | Npun_R0874
 | aspS | 6.1.1.12 | aspartyl-tRNA synthetase | Aazo_5000 | all2436 | Ava_0247 | Npun_F3458
 | cysS | 6.1.1.16 | cysteinyl-tRNA synthetase | Aazo_0710 | all1092 | Ava_3718 | Npun_F3946
 | [NAME] | 6.1.1.18 | glutaminyl-tRNA synthetase | (-) | (-) | (-) | (-)
 | gltX | 6.1.1.17 | glutamyl-tRNA synthetase | Aazo_3060 | all3205 | Ava_4861 | Npun_R1357
 | [NAME] | 6.1.1.14 | glycine tRNA synthetase beta subunit | [NAME] | alr4111 | Ava_0794 | Npun_R4010
 | hisS | 6.1.1.21 | histidyl tRNA synthetase | Aazo_2602 | all5012 | Ava_2260 | Npun_R5420
 | ileS | 6.1.1.5 | isoleucyl-tRNA synthetase | Aazo_5054 | alr1073 | Ava_3774 | Npun_F1478
 | leuS | 6.1.1.4 | leucyl-tRNA synthetase | Aazo_4197 | alr3283 | Ava_4936 | Npun_F4156
 | lysS | 6.1.1.6 | lysine tRNA synthetase | Aazo_4154(+) | (-) | (-) | (-)
 | lysS | 6.1.1.6 | lysine tRNA synthetase | (-) | all4071 | Ava_3150 | Npun_R5202
 | metG | 6.1.1.10 | methionyl-tRNA synthetase | Aazo_4858 | all0233 | Ava_2723 | [NAME]
 | pheS | 6.1.1.20 | phenylalanine tRNA synthetase alpha subunit | Aazo_3254 | all4845 | Ava_2115 | Npun_R0940
 | pheT | 6.1.1.20 | phenylalanine tRNA synthetase beta subunit | Aazo_4963 | alr4958 | Ava_2221 | Npun_F1087
 | proS | 6.1.1.15 | prolyl-tRNA synthetase | Aazo_0163 | alr5053 | Ava_2311 | Npun_F0436
 | serS | 6.1.1.11 | [NAME] synthetase | Aazo_2729 | all3976 | Ava_1724 | Npun_F4034
 | thrS | 6.1.1.3 | threonyl-tRNA synthetase | Aazo_2841 | alr0335 | Ava_2787 | Npun_F5857
 | trpS | 6.1.1.2 | tryptophanyl-tRNA synthetase | Aazo_4670 | all1269 | Ava_2993 | Npun_R5070
 | tyrS | 6.1.1.1 | tyrosyl-tRNA synthetase | Aazo_2067 | alr2982 | Ava_0925 | Npun_R3869
 | valS | 6.1.1.9 | valyl-tRNA synthetase | Aazo_4102 | all1318 | Ava_2982 | Npun_R4682
1.2.2.2. tRNA maturation and modification
 | [NAME] | 2.1.1.61 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase | Aazo_1582 | all1359 | Ava_4065 | Npun_F5444
 | mnmE |  | tRNA modification GTPase | Aazo_1908 | all4677 | Ava_1989 | Npun_F4302
 | mnmG/gidA |  | tRNA uridine 5-carboxymethylaminomethyl modification enzyme | Aazo_2420 | alr3561 | Ava_3539 | Npun_R6439
 | rnpA | 3.1.26.5 | protein component of ribonuclease P | Aazo_0685 | alr3413 | Ava_3433 | Npun_R1587
 | pth | 3.1.1.29 | peptidyl-tRNA hydrolase | Aazo_1919 | all0844 | [NAME] | Npun_F4317
 | iscS | 4.4.1.- | cysteine desulfurase | Aazo_1356 | all1457 | Ava_3914 | Npun_R0418
1.2.2.3. Ribosomal proteins
 | rplA |  | 50S ribosomal subunit protein L1 | Aazo_1039 | alr5301 | Ava_2553 | Npun_F5852
 | rplB |  | 50S ribosomal subunit protein L2 | Aazo_2562 | all4212 | Ava_0694 | Npun_R4387
 | rplC |  | 50S ribosomal subunit protein L3 | Aazo_2559 | all4215 | Ava_0691 | Npun_R4390
 | rplD |  | 50S ribosomal subunit protein L4 | Aazo_2560 | all4214 | Ava_0692 | Npun_R4389
 | rplE |  | 50S ribosomal subunit protein L5 | Aazo_2571 | all4203 | Ava_0703 | Npun_R4378
 | rplF |  | 50S ribosomal subunit protein L6 | Aazo_2573 | all4201 | Ava_0705 | Npun_R4376
 | [NAME] |  | 50S ribosomal subunit protein L9 | Aazo_2897 | all0579 | Ava_0329 | Npun_F2830
 | rplJ |  | 50S ribosomal subunit protein L10 | Aazo_1038 | alr5302 | Ava_2554 | Npun_F5853
 | rplK |  | 50S ribosomal subunit protein L11 | Aazo_1040 | [NAME] | Ava_2552 | Npun_F5851
 | rplL |  | 50S ribosomal subunit protein L12 | Aazo_1037 | alr5303 | Ava_2555 | Npun_F5854
 | rplM |  | 50S ribosomal subunit protein [NAME] | Aazo_2586 | all4188 | [NAME] | Npun_R4363
 | rplN |  | 50S ribosomal subunit protein L14 | Aazo_2569 | all4205 | Ava_0701 | Npun_R4380
 | rplO |  | 50S ribosomal subunit protein L15 | Aazo_2576 | all4198 | Ava_0708 | Npun_R4373
 | rplP |  | 50S ribosomal subunit protein L16 | [NAME] | all4208 | Ava_0698 | Npun_R4383
 | rplQ |  | 50S ribosomal subunit protein L17 | Aazo_2584 | all4190 | Ava_0716 | Npun_R4365
 | rplR |  | 50S ribosomal subunit protein L18 | Aazo_2574 | all4200 | Ava_0706 | Npun_R4375
 | rplS |  | 50S ribosomal subunit protein L19 | Aazo_1043 | alr5297 | Ava_2549 | Npun_F5848
 | rplT |  | 50S ribosomal subunit protein L20 | Aazo_4309 | alr3428 | Ava_3448 | Npun_R4937
 | [NAME] |  | 50S ribosomal subunit protein [NAME] | Aazo_0423 | [NAME] | Ava_1516 | Npun_R6114
 | rplV |  | 50S ribosomal subunit protein L22 | Aazo_2564 | all4210 | Ava_0696 | Npun_R4385
 | rplW |  | 50S ribosomal subunit protein [NAME] | Aazo_2561 | all4213 | Ava_0693 | Npun_R4388
 | rplX |  | 50S ribosomal subunit protein L24 | Aazo_2570 | asl4204 | Ava_0702 | Npun_R4379
 | rpmA |  | 50S ribosomal subunit protein L27 | Aazo_0424 | asl0146 | Ava_1515 | Npun_R6113
 | rpmB |  | 50S ribosomal subunit protein L28 | Aazo_1605 | asl2630 | Ava_0142 | (-)
 | rpmC |  | 50S ribosomal subunit protein L29 | [NAME] | asl4207 | Ava_0699 | Npun_R4382
 | rpmE |  | 50S ribosomal subunit protein L31 | Aazo_2588 | asl4186 | Ava_0720 | Npun_R4361
 | rpmF |  | 50S ribosomal subunit protein L32 | Aazo_2360 | asl3674 | Ava_3613 | Npun_R0842
 | rpmG |  | 50S ribosomal subunit protein L33 | Aazo_5172 | asl4452 | Ava_1320 | Npun_R4941
 | rpmH |  | 50S ribosomal subunit protein L34 | Aazo_0684 | asr3412 | Ava_3432 | Npun_R1588
 | rpmI |  | 50S ribosomal subunit protein L35 | Aazo_4310 | asr3427 | Ava_3447 | Npun_R4938
 | rpmJ |  | 50S ribosomal subunit protein L36 | Aazo_2580 | asl4194 | Ava_0712 | [NAME]
 | rpsB |  | 30S ribosomal subunit protein S2 | Aazo_4883 | [NAME] | Ava_2061 | Npun_R5570
 | rpsC |  | 30S ribosomal subunit protein S3 | Aazo_2565 | all4209 | Ava_0697 | Npun_R4384
 | rpsD |  | 30S ribosomal subunit protein S4 | Aazo_3730 | alr2737 | Ava_4303 | Npun_R1720
 | rpsE |  | 30S ribosomal subunit protein S5 | Aazo_2575 | all4199 | Ava_0707 | Npun_R4374
 | rpsF |  | 30S ribosomal subunit protein S6 | Aazo_4893 | all4802 | Ava_2072 | Npun_F5559
 | rpsG |  | 30S ribosomal subunit protein S7 | Aazo_0660 | all4339 | Ava_1289 | Npun_F3882
 | rpsH |  | 30S ribosomal subunit protein S8 | Aazo_2572 | all4202 | Ava_0704 | Npun_R4377
 | rpsI |  | 30S ribosomal subunit protein S9 | Aazo_2587 | all4187 | Ava_0719 | Npun_R4362
 | rpsJ |  | 30S ribosomal subunit protein S10 | Aazo_0663 | all4336 | Ava_1286 | Npun_F3885
 | rpsK |  | 30S ribosomal subunit protein S11 | Aazo_2582 | all4192 | Ava_0714 | Npun_R4367
 | rpsL |  | 30S ribosomal subunit protein S12 | Aazo_0659 | all4340 | Ava_1290 | Npun_F3881
 | rpsM |  | 30S ribosomal subunit protein S13 | Aazo_2581 | all4193 | Ava_0713 | Npun_R4368
 | rpsN |  | 30S ribosomal subunit protein S14 | Aazo_2726 | all3969 | Ava_1732 | Npun_F4037
 | rpsO |  | 30S ribosomal subunit protein S15 | Aazo_3907 | asl0749 | Ava_4651 | Npun_F0723
 | [NAME] |  | 30S ribosomal subunit protein S16 | Aazo_1143 | asr1953 | Ava_4357 | Npun_F2858
 | rpsQ |  | 30S ribosomal subunit protein S17 | Aazo_2568 | asl4206 | Ava_0700 | Npun_R4381
 | rpsR |  | 30S ribosomal subunit protein S18 | Aazo_5173 | asl4451 | Ava_1321 | Npun_R4940
 | rpsS |  | 30S ribosomal subunit protein S19 | Aazo_2563 | asl4211 | Ava_0695 | [NAME]
 | rpsT |  | 30S ribosomal subunit protein S20 | Aazo_1019 | asr1592 | Ava_4205 | Npun_F4983
1.2.2.4. Ribosome function, maturation and modification
 | [NAME] | 2.1.1.- | dimethyladenosine transferase | Aazo_3810 | alr3229 | Ava_4886 | Npun_R4912
 | rbfA |  | ribosome-binding factor A | Aazo_4927 | alr0063 | Ava_2665 | Npun_F0703
 | engA |  | GTP-binding protein | Aazo_3566 | alr0483 | Ava_2896 | Npun_R1702
 | obg |  | GTP-binding protein | Aazo_3952 | alr3739 | Ava_1586 | Npun_F3262
 | ychF |  | GTP-binding protein | Aazo_3794 | all0723 | Ava_4625 | Npun_R6366
 | era |  | GTP-binding protein | Aazo_1611 | [NAME] | Ava_4517 | Npun_F0483
 | cspR | 2.1.1.- | ribosomal methytransferase | Aazo_4609 | alr3352 | Ava_3194 | Npun_F6077
1.2.2.5. Translation factors
 | efp |  | elongation factor P | Aazo_0810 | all5058 | Ava_2315 | Npun_R0440
 | fusA | 3.6.5.3 | elongation factor G | Aazo_0661 | all4338 | Ava_1288 | Npun_F3883
 | fusA | 3.6.5.3 | elongation factor G | Aazo_0279 | alr4383 | Ava_3294 | Npun_R5063
 | frr |  | ribosome recycling factor | [NAME] | alr1208 | Ava_0629 | Npun_F6137
 | hemK | 2.1.1.- | N5-glutamine methyltransferase, modulation of release factors activity | Aazo_4971 | [NAME] | Ava_1484 | [NAME]
 | [NAME] |  | nitiation factor IF-1 | Aazo_2579 | asl4195 | Ava_0711 | Npun_R4370
 | infB |  | nitiation factor IF-2 | Aazo_0599 | alr3832 | Ava_1867 | Npun_R5773
 | infC |  | nitiation factor IF-3 | Aazo_4675 | all4623 | Ava_2038 | [NAME]
 | lepA |  | GTP-binding elongation factor | Aazo_3444 | all2508 | Ava_0440 | Npun_F1552
 | prfA |  | peptide chain release factor 1 (RF1) | Aazo_2589 | all4185 | Ava_0721 | Npun_R4360
 | smpB |  | tmRNA-binding protein | Aazo_0820 | alr5070 | Ava_2325 | Npun_F0451
 | tsf |  | elongation factor Ts | Aazo_4882 | all4791 | Ava_2060 | Npun_R5569
 | tufA | 3.6.5.3 | elongation factor [NAME] | Aazo_0662 | all4337 | Ava_1287 | [NAME]
1.2.3. [NAME] degradation
 | pnp | 2.7.7.8 | polyribonucleotide nucleotidyltransferase | Aazo_1071 | all4396 | Ava_3279 | Npun_R3625
 | rnc | 3.1.26.3 | ribonuclease III | Aazo_3201 | [NAME] | Ava_0797 | Npun_F1233
 | rnc | 3.1.26.3 | ribonuclease III | Aazo_4580 | alr0280 | Ava_3081 | Npun_R1331
2. Protein processing, folding and secretion
2.1 Protein post-translational modification
 | map | 3.4.11.18 | methionine aminopeptidase | Aazo_0183 | alr4150 | Ava_0754 | Npun_R3725
 | map | 3.4.11.18 | methionine aminopeptidase | Aazo_0333 | all1019 | Ava_3676 | Npun_R4996
 | pepA | 3.4.11.1 | aminopeptidase A/I | Aazo_2018 | alr0237 | Ava_2727 | Npun_F0097
2.2. Protein folding
 | dnaJ |  | Hsp70 co-chaperone | Aazo_1980 | [NAME] | Ava_0379 | Npun_F0123
 | dnaJ |  | Hsp70 co-chaperone | Aazo_3783 | alr4553 | Ava_2507 | Npun_F2810
 | dnaK |  | chaperone HSP70 | Aazo_1975 | alr2446 | Ava_0378 | Npun_F0122
 | dnaK |  | chaperone HSP70 | [NAME] | alr1742 | Ava_0295 | Npun_F0567
 | dnaK |  | chaperone HSP70 | Aazo_2048 | alr1742 | Ava_C0141 | Npun_F5907
 | dnaK |  | chaperone HSP70 | Aazo_4730 | alr2990 | [NAME] | Npun_R5998
 | groEL |  | class I heat-shock protein | Aazo_3205 | alr1896 | Ava_3766 | Npun_F1230
 | groEL |  | class I heat-shock protein | Aazo_2884 | alr3662 | Ava_3626 | Npun_R0829
 | groES |  | class I heat-shock protein | Aazo_2885 | alr3661 | Ava_3627 | Npun_R0830
 | grpE |  | Hsp70 co-chaperone | Aazo_1973 | alr2445 | Ava_0377 | Npun_F0121
 | grpE |  | Hsp70 co-chaperone | Aazo_1227 | all4473 | Ava_1312 | (-)
2.3. Protein translocation and secretion
 | ffh |  | protein component of signal recognition particle (SRP) | Aazo_1142 | alr1952 | Ava_4358 | Npun_F2857
 | ftsY |  | signal recognition particle receptor | Aazo_1588 | all1759 | Ava_0277 | Npun_F0081
 | secA |  | preprotein translocase subunit (ATPase) | Aazo_3269 | alr4851 | Ava_2124 | Npun_F0949
 | secE |  | membrane-embebed preprotein translocase subunit | Aazo_1042 | asr5298 | Ava_2550 | Npun_F5849
 | secY |  | membrane-embebed preprotein translocase subunit | Aazo_2577 | all4197 | Ava_0709 | Npun_R4372
2.4. Protein turnover
 | gcp | 3.4.24.57 | probable O-sialoglycoprotein endopeptidase | Aazo_4977 | alr0110 | Ava_1479 | Npun_R3861
 | hflB/ftsH | 3.4.24.- | ATP-dependent protease | Aazo_5220 | all4776 | Ava_2444 | Npun_F1740
 | hflB/ftsH | 3.4.24.- | ATP-dependent protease | Aazo_0357 | alr1261 | Ava_0575 | Npun_F4881
 | hflB/ftsH | 3.4.24.- | ATP-dependent protease | Aazo_3058 | all3642 | Ava_3190 | Npun_R1355
 | hflB/ftsH | 3.4.24.- | ATP-dependent protease | Aazo_2804 | all4936 | Ava_2234 | Npun_R2022
 | lon | 3.4.21.53 | ATP-dependent protease La | Aazo_0664 | all4335 | Ava_1285 | Npun_F3886
3. Cellular processes
3.1. Cell division
 | ftsZ |  | cytoskeletal cell division protein | Aazo_1902 | alr3858 | Ava_1837 | Npun_R4804
3.2. Transport
 | pitA |  | low-affinity inorganic phosphate transporter | Aazo_3724 | alr2336 | Ava_0155 | Npun_R1724
 | ptsG | 2.7.1.69 | phosphotransferase system (PTS) glucose-specific enzyme II | Aazo_5089 (+) | (-) | (-) | Npun_R1176
 | ptsH |  | histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) | Aazo_5089 (+) | (-) | (-) | Npun_R1176
 | ptsI | 2.7.3.9 | phosphotransferase system (PTS) enzyme I | Aazo_5089 (+) | (-) | (-) | Npun_R1176
4. Energetic and intermediary metabolism
4.1. Glycolysis
 | eno | 4.2.1.11 | enolase | Aazo_1631 | all3538 | Ava_3517 | Npun_R3508
 | [NAME] | 4.1.2.13 | fructose-1,6-bisphosphate aldolase | Aazo_4602 | [NAME] | Ava_2492 | Npun_F5584
 | gapA | 1.2.1.12 | glyceraldehyde 3-phosphate dehydrogenase | Aazo_1831 (*) | all2566 | Ava_0495 | Npun_R0031
 | gap2 | 1.2.1.13 | glyceraldehyde 3-phosphate dehydrogenase (NADP+) | Aazo_0813 | all5062 | Ava_2318 | Npun_R0444
 | gpmA | 5.4.2.1 | phosphoglycerate mutase | Aazo_1610 (*) | alr1107 | Ava_2177 | Npun_F0472
 | gpmA | 5.4.2.1 | phosphoglycerate mutase | Aazo_4242 | alr3338 | [NAME] | Npun_F6047
 | gpmA | 5.4.2.1 | phosphoglycerate mutase | Aazo_2546 | all4182 | Ava_0723 | Npun_R4351
 | ldh | 1.1.1.27 | L-lactate dehydrogenase | (-) | alr0058 | Ava_2660 | Npun_F2517
 | pfkA | 2.7.1.11 | 6-phosphofructokinase | Aazo_0224 (-) | alr1913 | Ava_3044 | Npun_R0482
 | pgi | 5.3.1.9 | glucose-6-phosphate isomerase | Aazo_2767 | alr1050 | Ava_3708 | Npun_F3925
 | pgk | 2.7.2.3 | phosphoglycerate kinase | Aazo_4275 | all4131 | Ava_0772 | [NAME]
 | pykA | 2.7.1.40 | pyruvate kinase | Aazo_2208 | all4008 | Ava_1694 | Npun_F4277
 | pykA | 2.7.1.40 | pyruvate kinase | Aazo_1832 (*) | all2564 | Ava_0494 | Npun_R0030
 | tpiA | 5.3.1.1 | triose phosphate isomerase | Aazo_1078 | alr4385 | Ava_3290 | Npun_R4322
4.2. Proton-motive force generation
 | atpA | 3.6.3.14 | ATP synthase alpha chain | Aazo_3338 | all0005 | Ava_2611 | Npun_F4863
 | atpB | 3.6.3.15 | ATP synthase A chain | Aazo_3333 | all0010 | Ava_2616 | Npun_F4858
 | atpC | 3.6.3.16 | ATP synthase epsilon chain | Aazo_1938 | all5038 | [NAME] | Npun_R4416
 | atpD | 3.6.3.17 | ATP synthase beta chain | Aazo_1939 | all5039 | Ava_2298 | Npun_R4417
 | atpE | 3.6.3.18 | ATP synthase C chain | Aazo_3334 | asl0009 | Ava_2615 | Npun_F4859
 | atpF | 3.6.3.19 | ATP synthase B chain | Aazo_3335 | all0008 | Ava_2614 | Npun_F4860
 | atpG | 3.6.3.20 | ATP synthase gamma chain | Aazo_3339 | all0004 | Ava_2610 | Npun_F4864
 | atpH | 3.6.3.21 | ATP synthase delta chain | Aazo_3337 | all0006 | Ava_2612 | Npun_F4862
 | yidC |  | essential for proper integration of ATPase into the membrane | Aazo_0687 | alr3415 | Ava_3435 | Npun_R1585
4.3. Penthose phosphate pathway
 | rpe | 5.1.3.1 | ribulose-phosphate 3-epimerase | Aazo_3229 | alr0782 | Ava_4675 | Npun_F1541
 | rpiA | 5.3.1.6 | ribose 5-phosphate isomerase | Aazo_4401 | all0888 | Ava_4491 | Npun_R1123
 | fkt | 2.2.1.1 | transketolase | Aazo_1635 | alr3344 | Ava_3645 | Npun_R4557
 | fkt | 2.2.1.1 | transketolase | Aazo_0419 | all4052 | Ava_1655 | (-)
4.4. Lipid metabolism
 | cdsA | 2.7.7.41 | phosphatidate cytidylyltransferase | [NAME] | [NAME] | Ava_1818 | Npun_R5818
 | fadD | 6.2.1.3 | acyl-CoA synthase | Aazo_1442 | alr3602 | Ava_3173 | Npun_F6411
 | gpsA | 1.1.1.94 | sn-glycerol-3-phosphate dehydrogenase | Aazo_0566 | all1693 | Ava_1163 | Npun_F0995
 | plsB | 2.3.1.15 | sn-glycerol-3-phosphate acyltransferase | (-) | (-) | (-) | (-)
 | plsC | 2.3.1.51 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | Aazo_2012 | alr0241 | Ava_2731 | Npun_F0101
 | psd | 4.1.1.65 | phosphatidylserine decarboxylase | (-) | (-) | (-) | (-)
 | pssA | 2.7.8.8 | phosphatidylserine synthase | (-) | (-) | (-) | (-)
4.5. Biosynthesis of nucleotides
 | adk | 2.7.4.3 | adenylate kinase | Aazo_1526 (*) | alr0068 | Ava_2670 | Npun_R2522
 | adk | 2.7.4.3 | adenylate kinase | [NAME] | [NAME] | Ava_0710 | Npun_R4371
 | dcd | 3.5.4.13 | dCTP deaminase | (-) | all0066 | Ava_2668 | Npun_F2524
 | gmk | 2.7.4.8 | [NAME] | Aazo_4981 | alr0106 | Ava_1475 | Npun_R3865
 | hpt | 2.4.2.8 | hypoxanthine phosphoribosyltransferase | (-) | (-) | (-) | (-)
 | ndk | 2.7.4.6 | nucleoside diphosphate kinase | Aazo_1845 | alr3402 | Ava_3424 | Npun_R6278
 | nrdE | 1.17.4.1 | ribonucleoside-diphosphate reductase (major subunit) | Aazo_1083 | all4035 | Ava_1670 | (-)
 | nrdF | 1.17.4.1 | ribonucleoside-diphosphate reductase (major subunit) | Aazo_1083 | all4035 | Ava_1670 | (-)
 | ppa | 3.6.1.1 | inorganic pyrophosphatase | Aazo_2698 | all3570 | Ava_3548 | Npun_F2553
 | prsA | 2.7.6.1 | phosphoribosylpyrophosphate synthase | Aazo_4372 | alr4670 | Ava_1994 | Npun_F2374
 | pyrG | 6.3.4.2 | CTP synthase | Aazo_4054 | alr5000 | Ava_2267 | Npun_F6033
 | thyA | 2.1.1.45 | thymidylate synthase | Aazo_5011 (+) | (-) | (-) | (-)
 | thyX | 2.1.1.148 | thymidylate synthase (FAD) | (-) | alr0515 | Ava_2917 | [NAME]
 | tmk | 2.7.4.9 | thymidylate kinase | Aazo_3024 | all4708 | Ava_1962 | Npun_F6527
 | trxA |  | thioredoxin | Aazo_3022 | all1866 | Ava_4761 | Npun_F6249
 | trxA |  | thioredoxin | Aazo_0912 | all2341 | Ava_0160 | Npun_R3962
 | trxA |  | thioredoxin | Aazo_3500 | alr0052 | Ava_2654 | Npun_R5587
 | trxA |  | thioredoxin | [NAME] | alr3955 | Ava_1747 | Npun_R6186
 | trxB | 1.8.1.9 | thioredoxin reductase | Aazo_4061 | all0737 | Ava_4637 | Npun_R0672
 | trxB | 1.8.1.9 | thioredoxin reductase | (-) | alr2204 | Ava_3376 | Npun_R0589
 | upp | 2.4.2.9 | uracil phosphoribosyltransferase | Aazo_0992 | all2063 | Ava_3111 | Npun_F4226
4.5. Biosynthesis of cofactors
 | coaA | 2.7.1.33 | pantothenate kinase | Aazo_1164 | alr3896 | Ava_1801 | Npun_R5836
 | coaD | 2.7.7.3 | 4'-phospho-pantetheine adenylyltransferase | Aazo_0903 | alr4700 | Ava_1966 | [NAME]
 | coaE | 2.7.1.24 | dephosphocoenzyme A kinase | Aazo_3459 | all1754 | Ava_0282 | Npun_R1865
 | dfp | 6.3.2.5/4.1.1.36 | phosphopantothenate cysteine ligase, 4'-phospho-pantothenyl-L-cysteine decarboxylase | Aazo_2496 | all3111 | Ava_3811 | Npun_F6058
 | folA | 1.5.1.3 | dihydrofolate reductase | Aazo_1890 (+) | (-) | (-) | (-)
 | glyA | 2.1.2.1 | glycine hydroxymethyltransferase | Aazo_4898 | alr4806 | Ava_2076 | Npun_F5156
 | metK | 2.5.1.6 | methionine adenosyltransferase | Aazo_1303 | all3244 | Ava_4899 | (-)
 | metK | 2.5.1.6 | methionine adenosyltransferase | Aazo_4838 | alr4124 | Ava_0780 | Npun_F2753
 | nadR | 2.7.7.1 | [NAME] | Aazo_2599 (-) | (-) | (-) | (-)
 | nadV | 2.4.2.12 | nicotinamide phosphoribosyltransferase | (-) | (-) | (-) | (-)
 | pdxY | 2.7.1.35 | [NAME] | (-) | (-) | (-) | (-)
 | ribF | 2.7.1.26/2.7.7.2 | [NAME], FMN adenylyltransferase | Aazo_3260 | alr4848 | Ava_2118 | Npun_F0943
 | yloS | 2.7.6.2 | thiamine pyrophosphokinase | (-) | (-) | (-) | (-)
5. Poorly characterized
 | [NAME] | 6.3.4.- | tRNA(Ile)-lysidine synthetase | Aazo_4955 | all0932 | Ava_0511 | Npun_F5958
 | [NAME] | 2.1.1.- | methyltrasferase | Aazo_2038 | all3354 | Ava_3196 | Npun_R4969
 | ybeY |  | conserved hypothetical protein | Aazo_4995 | all0271 | Ava_2782 | Npun_F1345
 | ycfF |  | histidine triad (HIT) protein | Aazo_3533 | all4087 | Ava_0817 | [NAME]
 | ycfH | 3.1.21.- | putative deoxyribonuclease, [NAME] family | Aazo_1018 | alr1593 | Ava_4206 | Npun_F4984
 | yoaE |  | conserved hypothetical protein | (-) | (-) | (-) | (-)
 | yqgF |  | Holliday junction resolvase YqgF | Aazo_4148 | alr3100 | Ava_3804 | Npun_F0324
 | yraL |  | tetrapyrrole methylase family protein | Aazo_1916 | all4680 | Ava_1987 | Npun_R2378
Bold locus tags indicates reverse best hits, (*) = [NAME] with functional copy present, (-) = Missing gene or pseudogene without functional copy, (+) = Unusual gene for cyanobacterial genomes.
NoAz = 'Nostoc azollae' 0708, [NAME] = Nostoc sp. PCC 7120, Avar = Anabaena variabilis ATCC 29413, [NAME] punctiforme PCC 73102