Spreadsheet: 2ca5c25f-eca3-4f06-8408-96c9644b9a7b
Sheet: Sheet1

Supplementary Table 3 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12 | Unnamed: 13
GeneAccession | GeneSymbol | GeneName | Ontology | Ontology | Ontology | Ontology | Ontology | Ontology | Ontology | Ontology | Ontology | Ontology | Disease Association
NM_007377 | Aatk | apoptosis-associated tyrosine kinase | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity | transferase activity | protein-tyrosine kinase activity | protein amino acid phosphorylation | Apoptosis
NM_009594 | Abl1 | v-abl [NAME] murine leukemia oncogene 1 | cellular physiological process | peptidyl-tyrosine phosphorylation | regulation of cell cycle | cancer related | protein-tyrosine kinase activity | intracellular signaling cascade | protein amino acid phosphorylation | cytoplasm | nucleus | protein binding | A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia
NM_133770 | ADCK4 | aarF domain containing kinase 4 | kinase activity | biological_process unknown | cellular_component unknown
[NAME] | Adk | adenosine kinase | adenosine kinase activity | kinase activity | transferase activity | nucleus | magnesium ion binding | purine ribonucleoside salvage
NM_130863 | Adrbk1 | adrenergic receptor kinase, beta 1 | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity | transferase activity | protein-tyrosine kinase activity | receptor activity | signal transducer activity | protein amino acid phosphorylation | signal transduction
NM_015804 | [NAME] | ATPase, class VI, type 11A | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | magnesium ion binding | membrane | catalytic activity | hydrolase activity | ATP binding | integral to membrane | ATPase activity | cation transport | metabolism
NM_029097 | Atp13a2 | ATPase type 13A2 | ATP binding | integral to membrane | hydrolase activity | cation transport | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | magnesium ion binding | membrane
NM_144921 | Atp1a3 | ATPase, Na+/K+ transporting, alpha 3 polypeptide | catalytic activity | hydrolase activity | monovalent inorganic cation transport | ATP binding | monovalent inorganic cation transporter activity | potassium ion transport | sodium ion transport | integral to membrane | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | magnesium ion binding | Defects in ATP1A3 are the cause of dystonia type 12
NM_175025 | Atp2c1 | ATPase, Ca++-sequestering | catalytic activity | hydrolase activity | ATP binding | calcium-transporting ATPase activity | calcium ion transport | proton transport | secretory pathway | integral to membrane | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | cation transport | Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD)
NM_013482 | BTK | Bruton agammaglobulinemia tyrosine kinase | I-kappaB kinase/NF-kappaB cascade | peptidyl-tyrosine phosphorylation | protein-tyrosine kinase activity | protein amino acid phosphorylation | ATP binding | kinase activity | protein serine/threonine kinase activity | transferase activity |  |  | Defects in BTK are the cause of X-linked agammaglobulinemia
NM_001025438 | CaMK2d | calcium/calmodulin-dependent protein kinase II, delta | ATP binding | kinase activity | protein serine/threonine kinase activity | transferase activity | G1/S transition of mitotic cell cycle | autophosphorylation | calcium ion transport
NM_007631 | Ccnd1 | cyclin D1 | [NAME] differentiation | cyclin-dependent protein kinase regulator activity | kinase activity | protein kinase activity | cytokinesis | re-entry into mitotic cell cycle | protein binding | protein amino acid phosphorylation | nucleus | [NAME] cell differentiation | A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy and parathyroid adenomas
NM_007658 | Cdc25a | cell division cycle 25 homolog A (S. cerevisiae) | cytokinesis | Cell Cycle, [NAME] Checkpoints | protein tyrosine phosphatase activity | M phase of mitotic cell cycle | mitosis | protein amino acid dephosphorylation | hydrolase activity | intracellular | phosphoprotein phosphatase activity | Cell cycle
NM_023117 | Cdc25b | cell division cycle 25 homolog B (S. cerevisiae) | phosphoprotein phosphatase activity | Cell Cycle, Mitotic | hydrolase activity | intracellular | protein tyrosine phosphatase activity | M phase of mitotic cell cycle | mitosis | protein amino acid dephosphorylation | cytokinesis
NM_009860 | Cdc25c | cell division cycle 25 homolog C (S. cerevisiae) | cytokinesis | protein binding | protein tyrosine phosphatase activity | M phase of mitotic cell cycle | mitosis | protein amino acid dephosphorylation | cytoplasm | nucleus | Cell Cycle [NAME], Mitotic | hydrolase activity
NM_194444 | CDK10 | cyclin-dependent kinase (CDC2-like) 10 | molecular_function unknown | biological_process unknown | intracellular | nucleus
NM_007691 | Chek1 | checkpoint kinase 1 homolog (S. pombe) | protein-tyrosine kinase activity | DNA damage checkpoint | protein amino acid phosphorylation | response to DNA damage stimulus | nucleus | Cell Cycle Checkpoints | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity
NM_027874 | [NAME] | casein kinase 1, delta | ATP binding | protein kinase activity | protein serine/threonine kinase activity | transferase activity | casein kinase I activity | protein-tyrosine kinase activity | protein amino acid phosphorylation | signal transduction | DNA repair | Wnt receptor signaling pathway | Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome
NM_013767 | Csnk1e | casein kinase 1, epsilon | Wnt receptor signaling pathway | protein-tyrosine kinase activity | protein amino acid phosphorylation | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity | transferase activity | Circadian rhythm |  | Associated with familial adenomatous polyposis
NM_007828 | [NAME] | death-associated kinase 3 | ATP binding | protein kinase activity | protein serine/threonine kinase activity | transferase activity | protein-tyrosine kinase activity | protein amino acid phosphorylation | nucleus | Apoptosis
NM_138306 | Dgkz | [NAME] | intracellular signaling cascade | nucleus | diacylglycerol binding | diacylglycerol kinase activity | kinase activity | transferase activity | protein kinase C activation
NM_023173 | Dusp12 | dual specificity phosphatase 12 | [NAME]/threonine phosphatase activity | protein amino acid dephosphorylation | phosphoprotein phosphatase activity
NM_019819 | Dusp14 | dual specificity phosphatase 14 | [NAME]/threonine phosphatase activity | protein amino acid dephosphorylation | hydrolase activity | phosphoprotein phosphatase activity
NM_026268 | Dusp6 | dual specificity phosphatase 6 | [NAME]/threonine phosphatase activity | protein amino acid dephosphorylation | MAP kinase phosphatase activity | phosphoprotein phosphatase activity | hydrolase activity
NM_178676 | Entpd3 | ectonucleoside triphosphate diphosphohydrolase 3 | apyrase activity | nucleoside diphosphate catabolism | integral to membrane | plasma membrane | hydrolase activity | NOT 5'-nucleotidase activity | nucleoside triphosphate catabolism
NM_008363 | IRAK1 | interleukin-1 receptor-associated kinase 1 | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity | transferase activity | protein binding | receptor activity | protein amino acid phosphorylation | signal transduction | magnesium ion binding | Assiciated with necrosis and inflammation
NM_181593 | Itpkc | inositol 1,4,5-trisphosphate 3-kinase C | inositol-trisphosphate 3-kinase activity | kinase activity |  |  |  |  |  |  |  |  | Genetic variations in ITPKC influence susceptibility to Kawasaki disease
NM_025730 | LRRK2 | leucine-rich repeat kinase 2 | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity | transferase activity | protein amino acid phosphorylation |  |  |  |  | Defects in LRRK2 are the cause of Parkinson disease 8 (PARK8)
NM_011948 | MAP3K4 | mitogen activated protein kinase kinase kinase 4 | magnesium ion binding | protein-tyrosine kinase activity | protein amino acid phosphorylation | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity | transferase activity
NM_008825 | Pfkfb2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | adenosine kinase activity | kinase activity | transferase activity | nucleus | magnesium ion binding | purine ribonucleoside salvage
XM_134059 | Ppapdc1 | phosphatidic acid phosphatase type 2 domain containing 1
NM_011100 | Prkacb | [NAME], cAMP dependent, catalytic, beta | protein-tyrosine kinase activity | protein amino acid phosphorylation | nucleus | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity | transferase activity
NM_153744 | Prkag3 | [NAME], AMP-activated, gamma 3 non-catatlytic subunit | kinase activity
NM_016795 | SRPK1 | serine/arginine-rich protein specific kinase 1 | protein-tyrosine kinase activity | protein amino acid phosphorylation | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity | transferase activity
NM_009370 | TGFBR1 | transforming growth factor, beta receptor I | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity | transferase activity | integral to membrane | protein binding | protein-tyrosine kinase activity | receptor activity | protein amino acid phosphorylation | Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A and type 2A
NM_011587 | TIE1 | [NAME] receptor 1 | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity | transferase activity | negative regulation of cell migration | [NAME] | integral to membrane | protein-tyrosine kinase activity | receptor activity
NM_021450 | Trpm7 | transient receptor potential cation channel, subfamily M, member 7 | calcium channel activity | cation transport | protein amino acid phosphorylation | ATP binding | kinase activity | protein serine/threonine kinase activity | transferase activity | integral to membrane | cation channel activity | ion channel activity | Defects in TRPM7 influence susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1
NM_183099 | TSSK5 | testis-specific serine kinase 5 | protein-tyrosine kinase activity | protein amino acid phosphorylation | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity | transferase activity
NM_026765 | Uckl1 | uridine-cytidine kinase 1-like 1 | biosynthesis | ATP binding | kinase activity | transferase activity | uridine kinase activity
NM_009469 | ULK1 | Unc-51 like kinase 1 (C. elegans) | cytoplasmic vesicle membrane | neuronal cell projection | protein binding | protein amino acid phosphorylation | ATP binding | kinase activity | protein kinase activity | protein serine/threonine kinase activity | transferase activity | [NAME] protein signal transduction
NM_009516 | Wee1 | wee 1 homolog (S. pombe) | ATP binding | protein kinase activity | protein serine/threonine kinase activity | transferase activity | protein-tyrosine kinase activity | mitosis | protein amino acid phosphorylation | nucleus | Cell Cycle [NAME], Mitotic