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Table S1. Gene expression cluster relation to surrogate measurements of atherosclerosis (QCA and IMT) | Gene expression cluster relation to surrogate measurements of atherosclerosis (QCA and IMT) | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9
In the first step of two-way clustering, we identified 60 expression cluster in five tissues from the STAGE cohort and additional 8 cluster in the carotid lesions. In the second step of the two way clustering, the patients were clustered in two groups for each gene cluster (P1 and [NAME] in the tables below) according to the gene expression values in each cluster. The average value and SD of the atherosclerosis measurement in each patient group is also given. Three cluster were identified to group the patients according to atheroscleosis surrogate measurements; in the atherosclerosis arterial wall cluster 5, in the visceral fat cluster 5 and in carotid lesions cluster 7. | In the first step of two-way clustering, we identified 60 expression cluster in five tissues from the STAGE cohort and additional 8 cluster in the carotid lesions. In the second step of the two way clustering, the patients were clustered in two groups for each gene cluster (P1 and [NAME] in the tables below) according to the gene expression values in each cluster. The average value and SD of the atherosclerosis measurement in each patient group is also given. Three cluster were identified to group the patients according to atheroscleosis surrogate measurements; in the aortic root/IMA cluster 5, in the mediastinal fat cluster 5 and in carotid lesions cluster 7.
 | Atherosclerosis arterial wall
 |  |  | #patients |  | Stenosis score |  |  |  | Jackknife
 |  | #[NAME] | P1 | P2 | P1 | P2 | P-val | [NAME] | 90 % CI
 | Cluster 1 | 25 | 32 | 5 | 5.81 ± 2.79 | 8.20 ± 2.39 | - | - | [0-∞]
 | Cluster 2 | 25 | 14 | 25 | 5.07 ± 1.77 | 6.72 ± 3.06 | 0.04004542756180302 | 0.2814310175232658 | [22-∞]
 | Cluster 3 | 519 | 33 | 6 | 6.36 ± 2.90 | 4.83 ± 1.33 | - | - | [308-∞]
 | Cluster 4 | 144 | 20 | 16 | 6.70 ± 3.10 | 5.06 ± 1.91 | 0.0604845268906973 | 0.290325729075347 | [124-∞]
 | Cluster 5* | 49 | 17 | 23 | 4.88 ± 1.63 | 7.00 ± 3.07 | 0.008301521562665776 | 0.00996182587519893 | [28-∞]
 | Cluster 6 | 537 | 24 | 13 | 6.58 ± 3.13 | 5.38 ± 2.06 | 0.1716821221532924 | 0.5352595192276594 | [516-∞]
 | Cluster 7 | 45 | 33 | 6 | 6.06 ± 2.79 | 6.50 ± 2.81 | - | - | [0-∞]
 | Cluster 8 | 19 | 34 | 5 | 5.56 ± 2.38 | 10.0 ± 2.12 | - | - | [0-∞]
 | Cluster 9 | 30 | 26 | 4 | 6.27 ± 2.82 | 6.25 ± 1.71 | - | - | [24-∞]
 | Cluster 10 | 29 | 32 | 7 | 5.31 ± 2.04 | 9.86 ± 2.67 | - | - | [23-∞]
 | Cluster 11 | 34 | 5 | 30 | 4.00 ± 2.12 | 6.27 ± 2.75 | - | - | [31-∞]
 | Cluster 12 | 36 | 29 | 9 | 6.24 ± 2.75 | 5.56 ± 3.00 | 0.5527198846514069 | 0.9388890466115082 | [25-∞]
 | Cluster 13 | 78 | 34 | 5 | 6.06 ± 2.72 | 6.60 ± 3.36 | - | - | [66-∞]
 | Cluster 14 | 957 | 15 | 23 | 5.27 ± 1.94 | 6.74 ± 3.14 | 0.08255523033161753 | 0.33022092132647 | [770-∞]
 | P-values were not computed for groups with less than 8 patients.
 | *Cluster presented in Figure 2.
 | † [NAME] is calculated according to [NAME] and Hochberg (1995) J R Statist Soc.
 | Liver
 |  |  | #patients |  | Stenosis score |  |  |  | Jackknife
 |  | #[NAME] | P1 | P2 | P1 | P2 | P-val | [NAME] | 90 % CI
 | Cluster 1 | 10 | 62 | 3 | 5.61 ± 2.71 | 3.67 ± 1.53 | - | - | [9-∞]
 | Cluster 2 | 89 | 42 | 21 | 5.67 ± 2.75 | 5.33 ± 2.74 | 0.6520625289162224 | 0.9388890466115082 | [67-∞]
 | Cluster 3 | 53 | 55 | 10 | 5.55 ± 2.82 | 5.40 ± 1.96 | 0.8435970112920451 | 0.9630403981997391 | [39-∞]
 | Cluster 4 | 37 | 48 | 17 | 5.60 ± 2.77 | 5.29 ± 2.54 | 0.6760416825686673 | 0.9388890466115082 | [32-∞]
 | Cluster 5 | 399 | 58 | 4 | 5.53 ± 2.84 | 5.50 ± 1.29 | - | - | [365-∞]
 | Cluster 6 | 138 | 51 | 11 | 5.55 ± 2.56 | 5.45 ± 3.70 | 0.9370084824891531 | 0.9630403981997391 | [128-∞]
 | Cluster 7 | 61 | 17 | 44 | 5.65 ± 2.26 | 5.50 ± 2.97 | 0.8365761724401198 | 0.9630403981997391 | [53-∞]
 | Cluster 8 | 218 | 58 | 7 | 5.55 ± 2.83 | 5.29 ± 1.11 | - | - | 157-∞]
 | Cluster 9 | 119 | 58 | 7 | 5.55 ± 2.83 | 5.29 ± 1.11 | - | - | [96-∞]
 | Cluster 10 | 35 | 30 | 33 | 5.47 ± 2.61 | 5.58 ± 2.88 | 0.8752643958362228 | 0.9630403981997391 | [17-∞]
 | Cluster 11 | 103 | 56 | 9 | 5.57 ± 2.79 | 5.22 ± 2.11 | 0.6678647345124354 | 0.9388890466115082 | [78-∞]
 | Cluster 12 | 46 | 57 | 5 | 5.40 ± 2.66 | 5.00 ± 0.71 | - | - | [40-∞]
 | Cluster 13 | 698 | 59 | 4 | 5.53 ± 2.81 | 5.50 ± 1.29 | - | - | [507-∞]
 | Cluster 14 | 230 | 51 | 11 | 5.41 ± 2.55 | 6.09 ± 3.65 | 0.5675702796383408 | 0.9388890466115082 | [173-∞]
 | Cluster 15 | 63 | 55 | 10 | 5.60 ± 2.82 | 5.10 ± 1.91 | 0.4932966243844105 | 0.9107014604019886 | [57-∞]
 | P-values were not computed for groups with less than 8 patients.
 | † [NAME] is calculated according to [NAME] and Hochberg (1995) J R Statist Soc.
 | Skeletal muscle
 |  |  | #patients |  | Stenosis score |  |  |  | Jackknife
 |  | #[NAME] | P1 | P2 | P1 | P2 | P-val | [NAME] | 90 % CI
 | Cluster 1 | 159 | 39 | 21 | 5.87 ± 2.60 | 5.00 ± 2.95 | 0.262630934295639 | 0.6634886761152984 | [0-∞]
 | Cluster 2 | 40 | 39 | 25 | 5.74 ± 2.60 | 5.04 ± 2.79 | 0.317502752528447 | 0.7176278019910988 | [0-∞]
 | Cluster 3 | 93 | 36 | 25 | 5.67 ± 2.54 | 5.40 ± 2.99 | 0.7173495286203095 | 0.953396558203611 | [0-∞]
 | Cluster 4 | 244 | 53 | 8 | 5.51 ± 2.71 | 5.62 ± 2.13 | 0.8932657932911533 | 0.9630403981997391 | [197-∞]
 | Cluster 5 | 7 | 47 | 14 | 5.68 ± 2.65 | 4.79 ± 2.78 | 0.2972223862668256 | 0.7133337270403814 | [0-∞]
 | Cluster 6 | 22 | 31 | 32 | 4.97 ± 2.06 | 6.00 ± 3.14 | 0.1276374994233812 | 0.4376142837373069 | [20-∞]
 | Cluster 7 | 50 | 60 | 5 | 5.47 ± 2.72 | 6.20 ± 2.59 | - | - | [46-∞]
 | Cluster 8 | 26 | 55 | 10 | 5.51 ± 2.49 | 5.60 ± 3.78 | 0.942977056570578 | 0.9630403981997391 | [25-∞]
 | Cluster 9 | 109 | 55 | 7 | 5.51 ± 2.49 | 5.71 ± 4.23 | - | - | [95-∞]
 | Cluster 10 | 18 | 56 | 8 | 5.54 ± 2.58 | 5.00 ± 3.46 | 0.6846065964875581 | 0.9388890466115082 | [0-∞]
 | Cluster 11 | 485 | 53 | 8 | 5.51 ± 2.71 | 5.62 ± 2.13 | 0.8932657932911533 | 0.9630403981997391 | [403-∞]
 | P-values were not computed for groups with less than 8 patients.
 | † [NAME] is calculated according to [NAME] and Hochberg (1995) J R Statist Soc.
 | Visceral fat
 |  |  | #patients |  | Stenosis score |  |  |  | Jackknife
 |  | #[NAME] | P1 | P2 | P1 | P2 | P-val | [NAME] | 90 % CI
 | Cluster 1 | 29 | 60 | 4 | 5.53 ± 2.78 | 5.50 ± 1.73 | - | - | [27-∞]
 | Cluster 2 | 23 | 53 | 12 | 5.68 ± 2.60 | 4.83 ± 3.10 | 0.3940178468108471 | 0.8222981150835069 | [0-∞]
 | Cluster 3 | 173 | 48 | 17 | 5.96 ± 2.52 | 4.29 ± 2.87 | 0.04389145644605855 | 0.2814310175232658 | [155-∞]
 | Cluster 4 | 47 | 44 | 21 | 5.05 ± 2.54 | 6.52 ± 2.79 | 0.04690516958721097 | 0.2814310175232658 | [40-∞]
 | Cluster 5* | 59 | 19 | 47 | 3.84 ± 1.83 | 6.22 ± 2.70 | 0.0001543858268769534 | 0.007410519690093763 | [38-∞]
 | Cluster 6 | 52 | 41 | 22 | 5.41 ± 2.55 | 5.77 ± 3.09 | 0.6441460752457436 | 0.9388890466115082 | [44-∞]
 | Cluster 7 | 60 | 56 | 9 | 5.52 ± 2.82 | 5.56 ± 1.88 | 0.9595405557794978 | 1 | [55-∞]
 | Cluster 8 | 168 | 50 | 15 | 5.98 ± 2.74 | 4.00 ± 1.93 | 0.003567543426483632 | 0.0570806948237381 | [130-∞]
 | Cluster 9 | 28 | 45 | 20 | 5.18 ± 2.67 | 6.30 ± 2.66 | 0.1250512281500865 | 0.4376142837373069 | [0-∞]
 | Cluster 10 | 8 | 58 | 7 | 5.72 ± 2.69 | 3.86 ± 2.19 | - | - | [8-∞]
 | Cluster 11 | 650 | 51 | 14 | 5.78 ± 2.53 | 4.57 ± 3.13 | 0.198695058515471 | 0.5352595192276594 | [573-∞]
 | Cluster 12 | 372 | 51 | 14 | 5.78 ± 2.53 | 4.57 ± 3.13 | 0.198695058515471 | 0.5352595192276594 | [295-∞]
 | Cluster 13 | 41 | 35 | 28 | 5.94 ± 2.76 | 5.07 ± 2.57 | 0.2007223197103723 | 0.5352595192276594 | [39-∞]
 | Cluster 14 | 103 | 48 | 17 | 5.96 ± 2.52 | 4.29 ± 2.87 | 0.04389145644605855 | 0.2814310175232658 | [100-∞]
 | Cluster 15 | 100 | 55 | 10 | 5.42 ± 2.74 | 6.10 ± 2.47 | 0.4438011135853797 | 0.8876022271707593 | [88-∞]
 | Cluster 16 | 32 | 52 | 12 | 5.46 ± 2.74 | 5.33 ± 2.15 | 0.8617362424068454 | 0.9630403981997391 | [31-∞]
 | Cluster 17 | 16 | 54 | 11 | 5.43 ± 2.77 | 6.00 ± 2.37 | 0.4868452521979631 | 0.9107014604019886 | [16-∞]
 | Cluster 18 | 56 | 60 | 5 | 5.48 ± 2.66 | 6.00 ± 3.39 | - | - | [16-∞]
 | Cluster 19 | 26 | 51 | 14 | 5.33 ± 2.61 | 6.21 ± 2.99 | 0.3289127425792536 | 0.7176278019910988 | [23-∞]
 | Cluster 20 | 33 | 42 | 21 | 5.45 ± 2.80 | 5.38 ± 2.38 | 0.9161237881972031 | 0.9630403981997391 | [31-∞]
 | P-values were not computed for groups with less than 8 patients.
 | *Cluster presented in Figure 3.
 | † [NAME] is calculated according to [NAME] and Hochberg (1995) J R Statist Soc.
 | Carotid lesion
 |  |  | #patients |  | IMT score |  |  |  | Jackknife
 |  | #[NAME] | P1 | P2 | P1 | P2 | P-val | [NAME] | 90 % CI
 | Cluster 1 | 16 | 14 | 10 | 1.23 ± 0.25 | 1.26 ± 0.25 | 0.7414219630410792 | 1 | [11-∞]
 | Cluster 2 | 136 | 18 | 6 | 1.22 ± 0.26 | 1.32 ± 0.16 | - |  | [0-∞]
 | Cluster 3 | 13 | 18 | 6 | 1.19 ± 0.23 | 1.41 ± 0.25 | - |  | [10-∞]
 | Cluster 4 | 27 | 8 | 11 | 1.20 ± 0.11 | 1.23 ± 0.29 | 0.7331464457706662 | 0.977 | [0-∞]
 | Cluster 5 | 23 | 19 | 5 | 1.19 ± 0.21 | 1.41 ± 0.30 | - |  | [10-∞]
 | Cluster 6 | 13 | 10 | 13 | 1.29 ± 0.27 | 1.21 ± 0.23 | 0.4698405654591398 | 0.94 | [0-∞]
 | Cluster 7* | 55 | 10 | 13 | 1.14 ± 0.22 | 1.35 ± 0.23 | 0.03908431929926529 | 0.156 | [32-∞]
 | Cluster 8 | 621 | 17 | 7 | 1.26 ± 0.22 | 1.20 ± 0.30 | - |  | [0-∞]
 | P-values were not computed for groups with less than 8 patients.
 | *Cluster presented in Figure 4.
 | † [NAME] is calculated according to [NAME] and Hochberg (1995) J R Statist Soc.