Spreadsheet: 02a0669d-f146-40bf-82ed-d1dd5ae4a761
Sheet: Table S3

Gene Ontology Analysis for HLH-25
Term | Genes | Count | % | P-Value
embryonic development ending in birth or egg hatching |  | 168 | 28.1 | 3.8e-09
regulation of growth |  | 136 | 22.8 | 2.9e-09
positive regulation of growth |  | 129 | 21.6 | 3.9e-08
nematode larval development |  | 122 | 20.4 | 3.2e-08
larval development |  | 122 | 20.4 | 3.3e-08
post-embryonic development |  | 122 | 20.4 | 6e-08
positive regulation of growth rate |  | 120 | 20.1 | 3.4e-08
regulation of growth rate |  | 120 | 20.1 | 3.5e-08
growth |  | 96 | 16.1 | 1.1e-06
body morphogenesis |  | 53 | 8.9 | 5.2e-07
reproductive developmental process |  | 50 | 8.4 | 0.019
hermaphrodite genitalia development |  | 42 | 7 | 0.028
genitalia development |  | 42 | 7 | 0.032
cell cycle |  | 37 | 6.2 | 3.2e-07
cell cycle process |  | 31 | 5.2 | 2e-05
regulation of multicellular organism growth |  | 31 | 5.2 | 0.0049
reproductive process in a multicellular organism |  | 30 | 5 | 0.028
multicellular organism reproduction |  | 30 | 5 | 0.028
morphogenesis of an epithelium |  | 26 | 4.4 | 0.0057
epithelium development |  | 26 | 4.4 | 0.0069
tissue morphogenesis |  | 26 | 4.4 | 0.0095
nitrogen compound biosynthetic process |  | 25 | 4.2 | 4.9e-05
sexual reproduction |  | 25 | 4.2 | 5.2e-05
cell cycle phase |  | 25 | 4.2 | 0.00019
M phase |  | 24 | 4 | 0.00039
molting cycle, protein-based cuticle |  | 22 | 3.7 | 0.003
molting cycle, collagen and cuticulin-based cuticle |  | 22 | 3.7 | 0.003
molting cycle |  | 22 | 3.7 | 0.0031
nucleobase, nucleoside and nucleotide biosynthetic process |  | 21 | 3.5 | 1.1e-05
nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process |  | 21 | 3.5 | 1.1e-05
positive regulation of multicellular organism growth |  | 21 | 3.5 | 0.075
positive regulation of multicellular organismal process |  | 21 | 3.5 | 0.092
generation of precursor metabolites and energy |  | 20 | 3.4 | 7e-06
gamete generation |  | 20 | 3.4 | 0.00022
cell division |  | 20 | 3.4 | 0.00063
multicellular organismal aging |  | 20 | 3.4 | 0.011
determination of adult life span |  | 20 | 3.4 | 0.011
aging |  | 20 | 3.4 | 0.011
nucleotide biosynthetic process |  | 19 | 3.2 | 6.8e-05
ribonucleotide biosynthetic process |  | 18 | 3 | 2.5e-07
ribonucleotide metabolic process |  | 18 | 3 | 4.1e-07
meiotic cell cycle |  | 18 | 3 | 0.00091
purine ribonucleotide biosynthetic process |  | 17 | 2.8 | 8.1e-07
purine ribonucleotide metabolic process |  | 17 | 2.8 | 1.3e-06
purine nucleotide biosynthetic process |  | 17 | 2.8 | 3.9e-05
purine nucleotide metabolic process |  | 17 | 2.8 | 6e-05
meiosis |  | 17 | 2.8 | 0.0015
M phase of meiotic cell cycle |  | 17 | 2.8 | 0.0016
ATP biosynthetic process |  | 15 | 2.5 | 1.6e-06
ATP metabolic process |  | 15 | 2.5 | 2.3e-06
nucleoside triphosphate biosynthetic process |  | 15 | 2.5 | 3.8e-06
purine nucleoside triphosphate biosynthetic process |  | 15 | 2.5 | 3.8e-06
ribonucleoside triphosphate biosynthetic process |  | 15 | 2.5 | 3.8e-06
purine ribonucleoside triphosphate biosynthetic process |  | 15 | 2.5 | 3.8e-06
ribonucleoside triphosphate metabolic process |  | 15 | 2.5 | 5.3e-06
purine nucleoside triphosphate metabolic process |  | 15 | 2.5 | 5.3e-06
purine ribonucleoside triphosphate metabolic process |  | 15 | 2.5 | 5.3e-06
nucleoside triphosphate metabolic process |  | 15 | 2.5 | 6.2e-06
chromosome segregation |  | 14 | 2.3 | 0.013
cytokinesis |  | 13 | 2.2 | 0.0099
proton transport |  | 12 | 2 | 5.3e-06
hydrogen transport |  | 12 | 2 | 6.6e-06
[NAME] |  | 12 | 2 | 0.00063
negative regulation of multicellular organism growth |  | 12 | 2 | 0.0022
negative regulation of multicellular organismal process |  | 12 | 2 | 0.0022
negative regulation of growth |  | 12 | 2 | 0.0027
female gamete generation |  | 12 | 2 | 0.011
meiotic chromosome segregation |  | 12 | 2 | 0.018
chromosome organization |  | 12 | 2 | 0.046
ATP synthesis coupled proton transport |  | 11 | 1.8 | 1.9e-05
energy coupled proton transport, down electrochemical gradient |  | 11 | 1.8 | 1.9e-05
ion transmembrane transport |  | 11 | 1.8 | 4.2e-05
oxidative phosphorylation |  | 11 | 1.8 | 0.00056
oogenesis |  | 11 | 1.8 | 0.016
cellular response to stress |  | 11 | 1.8 | 0.019
mitotic cell cycle |  | 11 | 1.8 | 0.086
protein-based cuticle development |  | 10 | 1.7 | 0.018
cuticle development |  | 10 | 1.7 | 0.018
germ cell development |  | 9 | 1.5 | 0.0026
reproductive cellular process |  | 9 | 1.5 | 0.024
collagen and cuticulin-based cuticle development |  | 9 | 1.5 | 0.042
cellular homeostasis |  | 9 | 1.5 | 0.046
regulation of cell cycle |  | 8 | 1.3 | 0.02
response to DNA damage stimulus |  | 8 | 1.3 | 0.058
response to abiotic stimulus |  | 8 | 1.3 | 0.092
mitosis |  | 7 | 1.2 | 0.061
M phase of mitotic cell cycle |  | 7 | 1.2 | 0.065
nuclear division |  | 7 | 1.2 | 0.065
organelle fission |  | 7 | 1.2 | 0.069
cell cycle switching |  | 5 | 0.8 | 0.026
regulation of mitotic cell cycle |  | 5 | 0.8 | 0.026
germline cell cycle switching, mitotic to meiotic cell cycle |  | 5 | 0.8 | 0.026
male gamete generation |  | 5 | 0.8 | 0.026
glycolysis |  | 5 | 0.8 | 0.026
spermatogenesis |  | 5 | 0.8 | 0.026
cell cycle switching, mitotic to meiotic cell cycle |  | 5 | 0.8 | 0.026
response to heat |  | 5 | 0.8 | 0.033
glucose catabolic process |  | 5 | 0.8 | 0.061
hexose catabolic process |  | 5 | 0.8 | 0.061
monosaccharide catabolic process |  | 5 | 0.8 | 0.061
alcohol catabolic process |  | 5 | 0.8 | 0.084
cellular carbohydrate catabolic process |  | 5 | 0.8 | 0.091
cellular chemical homeostasis |  | 4 | 0.7 | 0.042
acetyl-CoA catabolic process |  | 4 | 0.7 | 0.063
tricarboxylic acid cycle |  | 4 | 0.7 | 0.063
regulation of protein localization |  | 4 | 0.7 | 0.07
aerobic respiration |  | 4 | 0.7 | 0.07
cofactor catabolic process |  | 4 | 0.7 | 0.07
coenzyme catabolic process |  | 4 | 0.7 | 0.07
positive regulation of cell death |  | 4 | 0.7 | 0.078
acetyl-CoA metabolic process |  | 4 | 0.7 | 0.078
positive regulation of programmed cell death |  | 4 | 0.7 | 0.078
[NAME] |  | 4 | 0.7 | 0.086
[NAME] differentiation |  | 4 | 0.7 | 0.095
regulation of syncytium formation by plasma membrane fusion |  | 3 | 0.5 | 0.011
ER-nuclear signaling pathway |  | 3 | 0.5 | 0.069
[NAME] |  | 3 | 0.5 | 0.069
response to endoplasmic reticulum stress |  | 3 | 0.5 | 0.069
endoplasmic reticulum unfolded protein response |  | 3 | 0.5 | 0.069
cell maturation |  | 3 | 0.5 | 0.095
developmental maturation |  | 3 | 0.5 | 0.095
cellular response to unfolded protein |  | 3 | 0.5 | 0.095
tube development |  | 2 | 0.3 | 0.086
tube morphogenesis |  | 2 | 0.3 | 0.086
cell volume homeostasis |  | 2 | 0.3 | 0.086
tube lumen formation |  | 2 | 0.3 | 0.086
energy coupled proton transport, against electrochemical gradient |  | 2 | 0.3 | 0.086