Spreadsheet: ff833bbc-2d13-4f73-9bda-16343c18f8b3
Sheet: Sheet1

Supplementary table S7: Gene Set Enrichment Analysis (GSEA) of the top hypermethylated genes in endometrial cancer. GSEA was done using a one-tailed Fisher’s exact test of the top 325 hypermethylated genes (there were 325 unique hypermethylated genes among the top ranked 500 CpGs) in endometrial cancer (compared to non-neoplastic endometrium) in Set 1 against the Molecular Signatures Database (MSigDB, Broad Institute, www.broadinstitute.org/gsea/msigdb). The columns label the gene list, the number of genes in list, the number represented on 27k array, the corresponding fraction, the number that overlap with the top 325 hypermethyated genes, the P-value of enrichment, the adjusted P-value, and the gene symbols for the enriched genes. | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
BENPORATH_EED_TARGETS | 1062 | 915 | 0.861581920903955 | 108 | 8.20108958675365 | 7.46777312232639e-50 | 4.68826796619651e-46 | DRD4 DRD5 ST8SIA5 HOXD9 TRHDE HOXD12 PRDM14 SIX6 PITX2 EVX1 TMEFF2 PCDH8 OTP HOXA9 SORCS1 SPAG6 DGKI FRMPD4 DCC PTPRT CA3 ISL1 NTRK1 MAGI2 NPTX2 WDR8 KAL1 [NAME] MEGF11 PTGDR GHSR GRIN3A VSX1 PENK SORCS3 VSIG2 IGF2AS SOX1 KCNQ5 DLK1 SOX14 CNNM1 WT1 EOMES NIP PHOX2A TRH CX36 PRLHR TRPC5 ADCYAP1 ADCY8 GRIK3 IGSF21 HIST1H4F HIST1H3C HTR2C ADRA1A MLNR HAND2 HLA-G FERD3L HTR1B GATA4 CHX10 BNC1 HSPA1A CYP26C1 EPHA5 DIO3 TBX5 TP73 RAX OLIG2 FOXL1 GAD2 NEF3 [NAME] CART1 GABRA4 GABRA2 HCG9 [NAME] ADARB2 KCNV1 SLITRK3 VIPR2 DMRT3 IRXL1 ZNF312 GPR103 C2orf32 CBLN4 NKX6-2 CSMD3 BARHL2 PAX7 POU4F2 PRAC SLC6A3 WIT-1
BENPORATH_SUZ12_TARGETS | 1037 | 898 | 0.86595949855352 | 102 | 7.64620640768077 | 3.08030121547518e-45 | 9.66906551537659e-42 | DRD5 ADAM12 HOXD9 TRHDE HOXD12 SIX6 PITX2 TMEFF2 CRMP1 PCDH8 OTP SORCS1 SPAG6 DGKI FRMPD4 DCC PTPRT CACNA1A CA3 ISL1 NTRK1 NID2 WDR8 KAL1 [NAME] MEGF11 PTGDR GHSR GRIN3A VSX1 PENK SORCS3 VSIG2 IGF2AS PHLDB1 SOX1 SYT6 SOX14 CNNM1 WT1 EOMES NIP PHOX2A TRH CX36 PRLHR TRPC5 ADCYAP1 ADCY8 GRIK3 IGSF21 HTR2C ADRA1A MLNR HAND2 HTRA4 GATA4 CHX10 BNC1 HS3ST2 BHMT CYP26C1 EPHA5 DIO3 TBX5 TP73 RAX OLIG2 FOXL1 GAD2 NEF3 ADCY4 CART1 GABRA4 GABRA2 EPHA10 LHX5 POU3F1 SLC9A3 ADARB2 KCNV1 SLITRK3 VIPR2 DMRT3 IRXL1 ZNF312 GPR103 C2orf32 CBLN4 TNFRSF1B PCDH11Y NKX6-2 CSMD3 BARHL2 PAX7 POU4F2 PRAC CDH13 SLC6A3 WIT-1
BENPORATH_ES_WITH_H3K27ME3 | 1117 | 968 | 0.866606982990152 | 103 | 7.10202270931452 | 4.54695710339469e-43 | 9.51526556503729e-40 | DRD4 DRD5 ST8SIA5 HOXD9 HOXD12 SIX6 PITX2 EVX1 BCAN TMEFF2 CRMP1 PCDH8 OTP HOXA9 SORCS1 SPAG6 DGKI FRMPD4 DCC PTPRT GRM6 CACNA1A IRF4 ISL1 NTRK1 WDR8 KCNA1 [NAME] GHSR GRIN3A CHAD VSX1 PENK SORCS3 IGF2AS PHLDB1 SYT6 [NAME] CNNM1 WT1 EOMES NIP GPR26 PHOX2A TRH CX36 PRLHR TRPC5 ADCYAP1 RARRES2 ADCY8 GRIK3 IGSF21 HTR2C ADRA1A HAND2 FERD3L GATA4 CHX10 BNC1 HS3ST2 [NAME] CYP26C1 EPHA5 DIO3 TBX5 TP73 RAX OLIG2 FOXL1 GAD2 NEF3 ADCY4 GABRB2 GABRA4 GABRA2 HCG9 [NAME] ADARB2 KCNV1 SLITRK3 DMRT3 IRXL1 ZNF312 C2orf32 CBLN4 TNFRSF1B NKX6-2 CSMD3 BARHL2 PAX7 POU4F2 PRAC WIT-1 SLC6A3
BENPORATH_PRC2_TARGETS | 652 | 563 | 0.863496932515337 | 78 | 8.87062826894215 | 3.73468922883263e-40 | 5.86159474465281e-37 | WT1 EOMES NIP PHOX2A TRH DRD5 CX36 PRLHR TRPC5 ADCYAP1 ADCY8 GRIK3 IGSF21 HOXD9 HOXD12 SIX6 HTR2C PITX2 TMEFF2 ADRA1A PCDH8 HAND2 OTP SORCS1 SPAG6 GATA4 DGKI FRMPD4 CHX10 DCC PTPRT BNC1 CYP26C1 ISL1 EPHA5 DIO3 NTRK1 TBX5 TP73 WDR8 KCNA1 RAX OLIG2 FOXL1 MYOD1 GAD2 NEF3 ADCY4 GABRA4 GABRA2 PTGDR GHSR GRIN3A LHX5 VSX1 PENK SORCS3 POU3F1 SLC9A3 ADARB2 KCNV1 IGF2AS SLITRK3 DMRT3 IRXL1 ZNF312 C2orf32 [NAME] CSMD3 BARHL2 PAX7 POU4F2 PRAC SOX14 CNNM1 WIT-1 SLC6A3
HATADA_METHYLATED_IN_LUNG_CANCER_UP | 367 | 330 | 0.899182561307902 | 41 | 6.90570993074747 | 2.91806106501869e-19 | 3.66391747323747e-16 | TACR3 RIC3 ATP8A2 DRD4 ZNF177 NID2 PRLHR RARRES2 [NAME] HOXD12 SLC5A7 NEF3 OLFM1 CADPS CART1 ZNF22 GABRA2 ADRA1A CYP2W1 HKR1 PENK FERD3L AMT CYYR1 SPAG6 IGF2AS K6IRS2 HAAO SOX1 BNC1 [NAME] ISL1 EPHA5 CNNM1 CDH13 AJAP1
TRANSMEMBRANE_RECEPTOR_ACTIVITY | 411 | 377 | 0.917274939172749 | 34 | 4.69267548349513 | 4.94019482744158e-12 | 5.16909052111304e-09 | TACR3 PLXNB1 DRD4 DRD5 SSTR4 GRIK3 OPCML OPRM1 ADRA1A NMBR DDR2 HLA-G HTR1B PTPRR PTPRT GRM6 GRM1 F2RL3 GPR133 IL1R1 EPHA5 NTRK1 FLT4 GALR1 NPY GFRA1 GABRB2 GABRB1 NPR2 GHSR VIPR2 TNFRSF1B PTPRN TEK
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION | 272 | 260 | 0.955882352941177 | 28 | 5.64291441887987 | 6.24708950499387e-12 | 5.60274684462165e-09 | TACR3 DRD4 DRD5 PRLHR GALR1 SSTR4 GRIK3 GRIA4 LEP GABRG2 GABRB2 GABRB1 HTR2C OPRM1 GABRA4 GABRA2 PTGDR ADRA1A GHSR MLNR GRIN3A MCHR2 NMBR HTR1B [NAME]
RECEPTOR_ACTIVITY | 572 | 528 | 0.923076923076923 | 39 | 3.80114434916962 | 5.81059322395631e-11 | 4.15360824269167e-08 | TACR3 PLXNB1 DRD4 DRD5 SSTR4 GRIK3 OPCML OPRM1 ADRA1A NMBR DDR2 HLA-G HTR1B PTPRR PTPRT GRM6 GRM1 F2RL3 NR1I3 GPR133 IL1R1 EPHA5 NTRK1 FLT4 GALR1 NPY GFRA1 GABRG2 GABRB2 GABRB1 GABRA4 NPR2 GABRA2 [NAME] NR2E1 [NAME] PTPRN TEK
HOMEODOMAIN | 293 | 192 | 0.655290102389078 | 23 | 6.28621481869987 | 5.95451962157136e-11 | 4.15360824269167e-08 | CART1 BARHL2 EVX1 HOXA9 HOXD10 HOXD12 HOXD9 IRX2 [NAME] OTP PAX7 PHOX2A [NAME] TGIF VSX1 CHX10
SCHLESINGER_H3K27ME3_IN_NORMAL_AND_METHYLATED_IN_CANCER | 26 | 24 | 0.923076923076923 | 9 | 26.7685413002778 | 1.28140187601942e-09 | 8.04464097764995e-07 | GRM6 GRIA4 TRHDE HOXD12 HS3ST2 HOXA9 KCNA1 GAD2 GDF10
PLASMA_MEMBRANE | 1393 | 1293 | 0.928212491026561 | 59 | 2.31604963138202 | 1.05018068966198e-07 | 5.99366760881629e-05 | TACR3 DRD4 DRD5 ADAM12 TRHDE OPCML KCNB2 OPRM1 PCDH8 DDR2 PTPRT GRM6 RYR2 GRM1 CACNA1A PSCA NTRK1 EPB41L3 KCNA6 KCNA1 CARD11 [NAME] VSIG2 GPR75 KCNQ5 SGCG PTPRN TEK PRLHR TRPC5 SSTR4 ADCY8 GRIK3 GRIA4 SLC5A7 CD226 ADRA1A MLNR NMBR HTR1B F2RL3 IL1R1 ENPEP FLT4 GALR1 GABRG2 GABRB2 GABRB1 PCDHB15 PCDHB12 GABRA4 GABRA2 CDH24 [NAME] ALOX12 [NAME] SLC6A3
G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY | 185 | 167 | 0.902702702702703 | 17 | 5.14041654876412 | 2.22329805479071e-07 | 0.000116315543233134 | TACR3 NMBR HTR1B DRD4 DRD5 VIPR2 GALR1 SSTR4 GRM6 NPY GRM1 F2RL3 GPR133 OPCML OPRM1 ADRA1A [NAME]
REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS | 15 | 14 | 0.933333333333333 | 6 | 33.1256962452356 | 3.18847932044682e-07 | 0.000153979024413578 | NPY CDH13 GHSR IL20 LEP CART
AACTTT_UNKNOWN | 1475 | 1343 | 0.910508474576271 | 59 | 2.21731684020773 | 3.8440041655634e-07 | 0.000172376129652907 | RIC3 SALL3 HOXD10 TCERG1L PCSK1 PITX2 EVX1 TMEFF2 HAPLN1 PCDH8 OTP DDR2 DGKI GRM1 GPR133 OLFML3 CA3 ISL1 NPTX2 GFRA1 MYOD1 GRIN3A SORCS3 SOX1 SYT6 DLK1 PYGO1 SOX14 [NAME] ADCY8 GRIK3 SOCS2 CNTNAP2 CADPS HTR2C ADRA1A C7orf16 A2BP1 KCNS2 EPHA5 TBX5 ATP8A2 OLFM1 GABRB1 POU3F1 NR2E1 SLITRK3 VIPR2 DMRT3 PCDH11Y MLL3 CSMD3 BARHL2 PAX7 POU4F2 NETO1 CDH13
CELL_SURFACE_RECEPTOR_LINKED_SIGNAL_TRANSDUCTION_GO_0007166 | 622 | 578 | 0.929260450160772 | 33 | 2.8151635583974 | 8.81298251472601e-07 | 0.000368852694849666 | TACR3 DRD4 DRD5 PRLHR AGT SSTR4 ADCYAP1 UNQ739 GRIK3 GRIA4 OPRM1 ADRA1A MLNR NMBR HTR1B PTPRT GRM6 GRM1 F2RL3 NTRK1 FLT4 GALR1 NPY GDF10 GABRG2 GABRB2 GABRA4 NPR2 GABRA2 [NAME] GPR75 TEK CDH13
NEUROTRANSMITTER_RECEPTOR_ACTIVITY | 50 | 49 | 0.98 | 9 | 10.0230343125749 | 1.22702655681266e-06 | 0.000481454545229368 | TACR3 NMBR GABRG2 DRD4 DRD5 GABRA4 GABRA2 GALR1 SSTR4
CELL_CELL_SIGNALING | 400 | 379 | 0.9475 | 25 | 3.2408337487497 | 1.58589160655143e-06 | 0.000585660441525288 | TRH DRD4 AGT ADCYAP1 WISP3 TRHDE SLC5A7 PCSK1 HTR2C ADRA1A PCDH8 HTR1B GRM1 ENPEP TBX5 KCNA1 NPY GAD2 CART GABRB2 GHSR [NAME] SGNE1 TEK
G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY | 326 | 308 | 0.94478527607362 | 22 | 3.5121993099747 | 1.8703687499921e-06 | 0.000652343056247244 | TACR3 DRD4 DRD5 PRLHR GALR1 SSTR4 ADCYAP1 NPY GABRG2 GABRB2 OPRM1 GABRA4 GABRA2 ADRA1A GHSR MLNR NMBR HTR1B GPR75 GRM6 GRM1 F2RL3
NEUROTRANSMITTER_BINDING | 53 | 52 | 0.981132075471698 | 9 | 9.32118539539436 | 2.07083397159789e-06 | 0.000684247140720607 | TACR3 NMBR GABRG2 DRD4 DRD5 GABRA4 GABRA2 GALR1 SSTR4
REACTOME_GPCR_LIGAND_BINDING | 392 | 367 | 0.936224489795918 | 24 | 3.20289521090974 | 2.99584430016128e-06 | 0.000940395525820627 | TACR3 TRH DRD4 DRD5 PRLHR PROKR2 AGT SSTR4 ADCYAP1 HTR2C OPRM1 ADRA1A MLNR NMBR HTR1B GRM6 GRM1 F2RL3 GALR1 NPY PTGDR PENK VIPR2 GPR103
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | 292 | 274 | 0.938356164383562 | 20 | 3.57972703667422 | 3.99185928075394e-06 | 0.00119337583640825 | TACR3 TRH DRD4 DRD5 PRLHR PROKR2 AGT GALR1 SSTR4 NPY HTR2C OPRM1 PTGDR ADRA1A MLNR NMBR PENK HTR1B GPR103 F2RL3
PLASMA_MEMBRANE_PART | 1141 | 1056 | 0.925503943908852 | 47 | 2.19701628352194 | 5.01105388126314e-06 | 0.00142997255757136 | TACR3 DRD4 TRHDE OPCML KCNB2 OPRM1 PCDH8 DDR2 PTPRT GRM6 GRM1 NTRK1 EPB41L3 KCNA6 KCNA1 CARD11 GHSR VSIG2 GPR75 KCNQ5 SGCG PTPRN TEK PRLHR TRPC5 SSTR4 GRIK3 CD226 ADRA1A MLNR NMBR HTR1B F2RL3 IL1R1 ENPEP FLT4 GABRG2 GABRB2 GABRB1 PCDHB15 PCDHB12 GABRA4 GABRA2 CDH24 [NAME]
TRANSFAC | 1418 | 1242 | 0.875881523272214 | 52 | 2.06975444426175 | 8.52878273770121e-06 | 0.00232798687075166 | CART1 BARHL2 BNC1 EOMES EVX1 ZNF312 FHL2 FOXL1 GATA4 HAND2 HKR1 HOXA9 HOXD10 HOXD12 HOXD9 IRF4 IRX2 [NAME]MYOD1 NFE2 NKX6-2 NR1I3 NR2E1 OLIG2 PAX7 PHOX2A [NAME] RUNX3 SALL3 SIX6 SOX1 SOX11 SOX14 TBX5 TGIF TP73 UTF1 VSX1 WT1 ZIM2 ZNF132 ZNF135 ZNF154 ZNF177 ZNF22 ZNF96
V$OCT1_04 | 197 | 175 | 0.888324873096447 | 15 | 4.22160578156696 | 9.81237357757865e-06 | 0.00254144349386322 | NPTX2 SALL3 GRIK3 HOXD10 OPCML GABRG2 PITX2 GRIN3A SYT6 [NAME] BARHL2 [NAME]
REACTOME_DOWNSTREAM_EVENTS_IN_GPCR_SIGNALING | 448 | 421 | 0.939732142857143 | 25 | 2.88836546971595 | 1.012043442921e-05 | 0.00254144349386322 | TACR3 PLXNB1 TRH DRD4 DRD5 PROKR2 AGT SSTR4 ADCYAP1 ADCY8 HTR2C OPRM1 ADRA1A MLNR NMBR HTR1B DGKI F2RL3 GALR1 NPY ADCY4 PTGDR PENK VIPR2 GPR103
RHODOPSIN_LIKE_RECEPTOR_ACTIVITY | 131 | 122 | 0.931297709923664 | 12 | 4.88259004145407 | 1.94219139327626e-05 | 0.00468964521807244 | TACR3 NMBR HTR1B DRD4 DRD5 GALR1 SSTR4 F2RL3 OPCML OPRM1 ADRA1A [NAME]
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | 173 | 165 | 0.953757225433526 | 14 | 4.16482242520523 | 2.17611143576282e-05 | 0.00505986207174776 | TACR3 NMBR PENK TRH PRLHR PROKR2 AGT GALR1 SSTR4 GPR103 NPY F2RL3 OPRM1 MLNR
INTEGRAL_TO_PLASMA_MEMBRANE | 963 | 900 | 0.934579439252336 | 40 | 2.16433709515695 | 2.82566296790614e-05 | 0.00633554004018383 | TACR3 DRD4 TRHDE OPCML KCNB2 OPRM1 PCDH8 DDR2 PTPRT GRM6 GRM1 NTRK1 KCNA6 KCNA1 VSIG2 GPR75 KCNQ5 PTPRN TEK PRLHR TRPC5 SSTR4 GRIK3 CD226 ADRA1A MLNR NMBR HTR1B F2RL3 IL1R1 ENPEP FLT4 GABRG2 GABRB2 GABRB1 PCDHB15 PCDHB12 GABRA4 GABRA2 VIPR2
INTRINSIC_TO_PLASMA_MEMBRANE | 977 | 909 | 0.930399181166837 | 40 | 2.14039389258805 | 3.53503801453737e-05 | 0.00765274781216056 | TACR3 DRD4 TRHDE OPCML KCNB2 OPRM1 PCDH8 DDR2 PTPRT GRM6 GRM1 NTRK1 KCNA6 KCNA1 VSIG2 GPR75 KCNQ5 PTPRN TEK PRLHR TRPC5 SSTR4 GRIK3 CD226 ADRA1A MLNR NMBR HTR1B F2RL3 IL1R1 ENPEP FLT4 GABRG2 GABRB2 GABRB1 PCDHB15 PCDHB12 GABRA4 GABRA2 VIPR2
MEMBRANE | 1942 | 1781 | 0.917095777548919 | 65 | 1.80720448288399 | 4.70211825225431e-05 | 0.00983996612921752 | TACR3 DRD4 DRD5 TRHDE KCNB2 PTPRT GRM6 GRM1 GPR133 EPB41L3 KCNA6 KCNA1 CARD11 VSIG2 GPR75 SGCG PTPRN TEK PRLHR SSTR4 ADCY8 GRIK3 GRIA4 SLC5A7 ADRA1A MLNR HTR1B FLT4 ACP5 CDH24 [NAME] ADAM12 OPCML OPRM1 PCDH8 DDR2 SORCS1 RYR2 CACNA1A PSCA NTRK1 [NAME] DLK1 TRPC5 CD226 NMBR F2RL3 HS3ST2 IL1R1 ENPEP EPHA5 GALR1 GABRG2 GABRB2 GABRB1 PCDHB15 PCDHB12 GABRA4 GABRA2 ALOX12 [NAME] SLC6A3
INTEGRAL_TO_MEMBRANE | 1301 | 1205 | 0.926210607225211 | 48 | 1.94173910581161 | 6.99204826889209e-05 | 0.0141600254942273 | TACR3 DRD4 TRHDE OPCML KCNB2 OPRM1 PCDH8 DDR2 PTPRT GRM6 GRM1 CACNA1A GPR133 NTRK1 KCNA6 KCNA1 VSIG2 GPR75 KCNQ5 DLK1 PTPRN TEK PRLHR TRPC5 SSTR4 GRIK3 SLC5A7 CD226 ADRA1A MLNR NMBR HTR1B F2RL3 HS3ST2 IL1R1 ENPEP EPHA5 FLT4 GALR1 GABRG2 GABRB2 GABRB1 PCDHB15 PCDHB12 GABRA4 GABRA2 ACP5 VIPR2
INTRINSIC_TO_MEMBRANE | 1319 | 1218 | 0.923426838514026 | 48 | 1.91826594586008 | 9.0854676321374e-05 | 0.0174644702167016 | TACR3 DRD4 TRHDE OPCML KCNB2 OPRM1 PCDH8 DDR2 PTPRT GRM6 GRM1 CACNA1A GPR133 NTRK1 KCNA6 KCNA1 VSIG2 GPR75 KCNQ5 DLK1 PTPRN TEK PRLHR TRPC5 SSTR4 GRIK3 SLC5A7 CD226 ADRA1A MLNR NMBR HTR1B F2RL3 HS3ST2 IL1R1 ENPEP EPHA5 FLT4 GALR1 GABRG2 GABRB2 GABRB1 PCDHB15 PCDHB12 GABRA4 GABRA2 ACP5 VIPR2
V$IPF1_Q4 | 187 | 165 | 0.882352941176471 | 13 | 3.82954343570303 | 9.18011336653637e-05 | 0.0174644702167016 | PCDHGB7 OTP CTSK NR2E1 HSPB2 RAX PLCD1 SALL3 OLFM1 BARHL2 PITX2 LECT1 HAPLN1
PEPTIDE_RECEPTOR_ACTIVITY | 50 | 49 | 0.98 | 7 | 7.37968132339382 | 0.00010412790339578 | 0.0187034060980446 | TACR3 F2RL3 NMBR OPCML OPRM1 GALR1 SSTR4
module_113 | 106 | 103 | 0.971698113207547 | 10 | 4.78895548794045 | 0.00010692948042083 | 0.0187034060980446 | TACR3 FLT4 DRD4 KCNB1 PROZ NR1I3 OPCML CADPS ENPEP CRMP1
FEEDING_BEHAVIOR | 24 | 22 | 0.916666666666667 | 5 | 12.9571599348474 | 0.000107251134044219 | 0.0187034060980446 | NPY GHSR HTR2C LEP CART
LOPES_METHYLATED_IN_COLON_CANCER_UP | 23 | 23 | 1 | 5 | 12.2377661160892 | 0.000134534499312292 | 0.0228272320725019 | PENK CDKN2A OPCML TMEFF2 MYOD1
module_220 | 328 | 325 | 0.990853658536585 | 19 | 2.80348257987177 | 0.000145663157872775 | 0.024065086976981 | ADAM12 KAL1 HOXD10 DPYSL4 ACTA2 CART1 SIX6 CRMP1 DDR2 SERPINF1 KRTHB5 POU3F1 PTPRR DLK1 PAX7 ISL1 TEK NTRK1 TBX5
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER | 88 | 88 | 1 | 9 | 5.0623583818254 | 0.000158270540250654 | 0.0254774987613745 | WT1 TP73 [NAME] PAX7 GATA4 CDH13 WIT-1 DCC
[NAME] | 1633 | 1500 | 0.91855480710349 | 55 | 1.787010361489 | 0.000178881019354205 | 0.0280753759876424 | TACR3 DRD4 TRHDE KCNB2 PTPRT GRM6 GRM1 GPR133 EPB41L3 KCNA6 KCNA1 CARD11 VSIG2 GPR75 SGCG PTPRN TEK PRLHR SSTR4 GRIK3 SLC5A7 ADRA1A MLNR HTR1B FLT4 ACP5 CDH24 [NAME] OPCML OPRM1 PCDH8 DDR2 CACNA1A NTRK1 [NAME] DLK1 TRPC5 CD226 NMBR F2RL3 HS3ST2 IL1R1 ENPEP EPHA5 GALR1 GABRG2 GABRB2 GABRB1 PCDHB15 PCDHB12 GABRA4 GABRA2 CDH13
V$NRSF_01 | 76 | 71 | 0.934210526315789 | 8 | 5.63120841953223 | 0.000186417236493186 | 0.0285445709927858 | SYT6 GRM1 GDAP1L1 GABRG2 POU4F2 PTPRN KCNH8 [NAME]
module_100 | 529 | 506 | 0.956521739130435 | 25 | 2.36335594048991 | 0.000200908219355511 | 0.0300309952646166 | PLXNB1 AGT CNTNAP2 PCSK1 SIX6 CRMP1 ACSL6 EFS CACNA1A MAGI2 EPB41L3 NID2 KAL1 NPY NEF3 DPYSL4 OLFM1 CART GABRG2 PENK AMT DLK1 SGNE1 PTPRN SLC6A3
[NAME] | 531 | 507 | 0.954802259887006 | 25 | 2.35828190483913 | 0.000207063261994064 | 0.0302312362511334 | PLXNB1 AGT CNTNAP2 PCSK1 SIX6 CRMP1 ACSL6 EFS CACNA1A MAGI2 EPB41L3 NID2 KAL1 NPY NEF3 DPYSL4 OLFM1 CART GABRG2 PENK AMT DLK1 SGNE1 PTPRN SLC6A3
SYSTEM_DEVELOPMENT | 855 | 790 | 0.923976608187134 | 34 | 2.06571586352108 | 0.00021496751868626 | 0.0305815473870671 | ADAM12 IL20 UNQ739 SIX6 PITX2 CRMP1 KRTHB5 KAL1 [NAME] GDF10 [NAME] SOX11 SGCG SFTPB SOX14 TRPC5 C7orf16 HAND2 GATA4 BNC1 TBX5 PSPN OLFM1 CART ACTA1 CART1 PCDHB15 PCDHB12 NR2E1 IRXL1 POU4F2 CDH13
REGULATION_OF_RESPONSE_TO_STIMULUS | 59 | 55 | 0.932203389830508 | 7 | 6.45334412618519 | 0.000219205102328452 | 0.0305815473870671 | NPY APOBEC3G LEP CART CDH13 GHSR IL20
[NAME] | 706 | 664 | 0.940509915014164 | 30 | 2.16351653847735 | 0.000225808795977687 | 0.0308179917640852 | TACR3 PLXNB1 ST8SIA5 AGT ADCY8 PLCD1 GRIK3 CADPS OPRM1 GATA4 BIRC4BP RYR2 F2RL3 BHMT IRF4 FUT5 LECT1 EPB41L3 NFE2 KCNB1 [NAME] SLITRK3 VIPR2 [NAME] CKMT2
GCCNNNWTAAR_UNKNOWN | 114 | 113 | 0.991228070175439 | 10 | 4.32054877837272 | 0.000230944750985597 | 0.0308483222699485 | OTP ADAM12 DGKI SLC2A14 SOCS2 SLC5A7 JPH4 OPCML HTR2C ISL1
HOQUE_METHYLATED_IN_CANCER | 56 | 56 | 1 | 7 | 6.32124321617355 | 0.000245758274070215 | 0.0313964103292794 | WT1 RASSF1 DRD4 RUNX3 CDKN2A GATA4 CDH13
module_66 | 536 | 513 | 0.957089552238806 | 25 | 2.32821825070725 | 0.000247634798362513 | 0.0313964103292794 | PLXNB1 AGT CNTNAP2 PCSK1 SIX6 CRMP1 ACSL6 EFS CACNA1A MAGI2 EPB41L3 NID2 KAL1 NPY NEF3 DPYSL4 OLFM1 CART GABRG2 PENK AMT DLK1 SGNE1 PTPRN SLC6A3
MULTICELLULAR_ORGANISMAL_DEVELOPMENT | 1040 | 962 | 0.925 | 39 | 1.95004710501623 | 0.000250051053912706 | 0.0313964103292794 | ADAM12 IL20 UNQ739 SIX6 PITX2 CRMP1 HOXA9 KRTHB5 PTPRR KAL1 TGIF MYOD1 DPYSL4 GDF10 [NAME] SOX11 DLK1 SGCG SFTPB SOX14 TRPC5 C7orf16 HAND2 GATA4 BNC1 TBX5 NFE2 PSPN OLFM1 CART ACTA1 CART1 PCDHB15 PCDHB12 NR2E1 IRXL1 POU4F2 CDH13
module_215 | 15 | 15 | 1 | 4 | 15.9796457109243 | 0.000281777707105355 | 0.0346862832393611 | GABRB2 GABRB1 GABRG2 GABRA2
TRANSCRIPTION_FACTOR_ACTIVITY | 341 | 326 | 0.956011730205279 | 18 | 2.62961086545822 | 0.000432886612930525 | 0.0522627337688045 | TP73 NFE2 FOXL1 TGIF MYOD1 RUNX3 CART1 PITX2 EVX1 HAND2 [NAME] NR1I3 PAX7 POU4F2 SOX14 TBX5
TTANWNANTGGM_UNKNOWN | 50 | 45 | 0.9 | 6 | 6.79083774465716 | 0.000480593957762671 | 0.056927714468567 | [NAME] PENK OLFML3 SOX14 CKMT2
ANATOMICAL_STRUCTURE_DEVELOPMENT | 1005 | 930 | 0.925373134328358 | 37 | 1.90329714210971 | 0.000518923680328288 | 0.0593599097535818 | ADAM12 IL20 UNQ739 SIX6 PITX2 CRMP1 KRTHB5 KAL1 [NAME] GDF10 [NAME] SOX11 SGCG SFTPB SOX14 EOMES TRPC5 C7orf16 HAND2 GATA4 BNC1 TBX5 PSPN OLFM1 CART ACTA1 CART1 PCDHB15 PCDHB12 NR2E1 IRXL1 ACTN2 PAX7 POU4F2 CDH13
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | 157 | 148 | 0.942675159235669 | 11 | 3.5758749584019 | 0.000520037438108792 | 0.0593599097535818 | TACR3 NMBR TRH DGKI PROKR2 AGT GPR103 F2RL3 HTR2C ADRA1A MLNR
V$EVI1_05 | 137 | 126 | 0.91970802919708 | 10 | 3.83318991262283 | 0.000554500229724636 | 0.0610325926314419 | A2BP1 SORCS1 HSPB2 SALL3 HOXD10 SOX11 [NAME] SOX14 ISL1
SYSTEM_PROCESS | 558 | 511 | 0.915770609318996 | 24 | 2.23253064872092 | 0.000558847213448941 | 0.0610325926314419 | DRD4 AGT SLC5A7 MYO3A KCNB2 SIX6 HTR2C OPRM1 ADRA1A HTR1B RYR2 GRM1 NFE2 [NAME] NPY GAD2 CART GABRB2 ACTA1 [NAME]
[NAME] | 409 | 362 | 0.885085574572127 | 19 | 2.49427746342234 | 0.000563856383023834 | 0.0610325926314419 | [NAME] HTR2C DPT ADRA1A HTR1B [NAME] ISL1 TBX5 ATP8A2 GABRB2 CDH8 HAAO PHLDB1 PAX7
V$TEF_Q6 | 197 | 175 | 0.888324873096447 | 12 | 3.28330210540887 | 0.000607755473634922 | 0.0646515107084256 | NPTX2 IL20 SALL3 HOXD10 HOXD12 DGKI SYT6 ZFP42 PCDH11Y CYP26C1 OLFML3 ENPEP
[NAME] | 374 | 336 | 0.898395721925134 | 18 | 2.54526016098578 | 0.000617886371854975 | 0.0646515107084256 | ATP8A2 ADCYAP1 WISP3 OPCML GABRB2 SIX6 HTR2C ADRA1A [NAME] HTR1B ZNF132 PTPRR HAAO PHLDB1 F2RL3 CA3 PAX7 ISL1
YNGTTNNNATT_UNKNOWN | 275 | 254 | 0.923636363636364 | 15 | 2.81080031452576 | 0.000647839445019238 | 0.0666743612431274 | EOMES CNTNAP2 [NAME] HTR2C GABRA4 GRIN3A [NAME] PDE1C OLFML3 SOX14 NTRK1
V$CDPCR3HD_01 | 189 | 179 | 0.947089947089947 | 12 | 3.20375154240963 | 0.000742590250558432 | 0.0731006597757451 | A2BP1 GATA4 KCNA1 HOXD10 PRDM14 [NAME]
FARMER_BREAST_CANCER_CLUSTER_5 | 19 | 19 | 1 | 4 | 11.7108875840216 | 0.000745212205423333 | 0.0731006597757451 | NID2 SERPINF1 ADAM12 CTSK
NEURON_PROJECTION | 20 | 19 | 0.95 | 4 | 11.7108875840216 | 0.000745212205423333 | 0.0731006597757451 | NEF3 CDH13 GHSR ACTN2
module_387 | 49 | 49 | 1 | 6 | 6.15761322398783 | 0.00076527279001144 | 0.0739135780875665 | MYOD1 SGCG [NAME] ADAM12 [NAME]
V$PAX2_02 | 202 | 181 | 0.896039603960396 | 12 | 3.16538798821202 | 0.000818876251011796 | 0.077892501573516 | EPB41L3 DRD5 SLC2A14 [NAME] [NAME] SYT6 [NAME] TBX5
MORF_SUPT3H | 321 | 288 | 0.897196261682243 | 16 | 2.63657987772225 | 0.000835383373173744 | 0.0782766689072353 | PCDHGB7 RUFY3 WISP3 OPCML GABRB2 SIX6 HTR2C [NAME] PTPRR PHLDB1 F2RL3 SOX11 CA3 PAX7 ISL1
ONDER_CDH1_TARGETS_2_UP | 255 | 234 | 0.917647058823529 | 14 | 2.84471231648567 | 0.000857786624111415 | 0.0791938886201686 | NPTX2 NID2 ADAM12 KAL1 MAGEH1 [NAME] ZNF22 GLRX DDR2 SERPINF1 DGKI SGNE1 OLFML3 ANKRD25
CELL_PROJECTION | 105 | 89 | 0.847619047619048 | 8 | 4.37464118224231 | 0.000872875619618182 | 0.0794190310139557 | DNAI1 SPAG6 ACTN2 CACNA1A NEF3 MYO3A CDH13 GHSR
module_316 | 70 | 69 | 0.985714285714286 | 7 | 4.9915969645691 | 0.000891358310139312 | 0.0799421067293515 | RYR2 GRIK3 GABRG2 KCNB2 KCNA6 GABRA2 KCNA1
module_329 | 51 | 51 | 1 | 6 | 5.88320687732058 | 0.000949216315200199 | 0.0839321130538993 | MYOD1 SGCG [NAME] ADAM12 [NAME]
SYNAPTIC_TRANSMISSION | 172 | 160 | 0.930232558139535 | 11 | 3.28531014729377 | 0.000995254064354231 | 0.0867806252224426 | HTR1B DRD4 KCNA1 NPY GRM1 KCNQ5 SLC5A7 GAD2 CART GABRB2 HTR2C
V$OCT1_07 | 126 | 113 | 0.896825396825397 | 9 | 3.8390635440594 | 0.0010138248469139 | 0.0871889368345953 | IRX2 IGF2AS [NAME]
NEUROPEPTIDE_RECEPTOR_ACTIVITY | 22 | 21 | 0.954545454545455 | 4 | 10.3345283756309 | 0.00111059650663693 | 0.0942206063333326 | TACR3 GALR1 NMBR SSTR4
YCATTAA_UNKNOWN | 431 | 385 | 0.893271461716937 | 19 | 2.33382657825799 | 0.00117409484493577 | 0.0982795658200902 | PCDHGB7 PABPC5 SSTR4 GRIK3 HOXD10 OPCML RUNX3 HTR2C PITX2 HAND2 A2BP1 HOXA9 FERD3L SORCS1 NPTX2 RAX GDF10 NR2E1 [NAME]
NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS | 11 | 10 | 0.909090909090909 | 3 | 18.7753221218576 | 0.00120277188015125 | 0.0993552876788096 | LEP CART GHSR
TTANTCA_UNKNOWN | 718 | 638 | 0.88857938718663 | 27 | 2.00363750431005 | 0.00124268438583614 | 0.101319124341289 | ADCYAP1 ADCY8 CD226 PCSK1 RUNX3 HTR2C PITX2 TMEFF2 OTP A2BP1 HOXA9 PTPRR DGKI RYR2 RASSF1 ISL1 NPTX2 GAL3ST3 GFRA1 GABRB1 LHX5 VSX1 NR2E1 DNAI1 PCDH11Y BARHL2 SOX14
BEHAVIOR | 149 | 141 | 0.946308724832215 | 10 | 3.39060931869564 | 0.00132292376816462 | 0.10312749125019 | KAL1 ADCY8 NPY LEP CART HTR2C OPRM1 C7orf16 CDH13 GHSR
SECOND_MESSENGER_MEDIATED_SIGNALING | 146 | 141 | 0.965753424657534 | 10 | 3.39060931869564 | 0.00132292376816462 | 0.10312749125019 | NMBR HTR1B DRD5 GALR1 SSTR4 ADCYAP1 NPY F2RL3 OPRM1 CDH13
NEUROPEPTIDE_BINDING | 23 | 22 | 0.956521739130435 | 4 | 9.7586677646954 | 0.00133356214499086 | 0.10312749125019 | TACR3 GALR1 NMBR SSTR4
KEGG_CALCIUM_SIGNALING_PATHWAY | 178 | 166 | 0.932584269662921 | 11 | 3.15679521611926 | 0.00134247035273693 | 0.10312749125019 | TACR3 DRD5 PDE1C ADCY8 PLCD1 RYR2 GRM1 CACNA1A ADCY4 HTR2C ADRA1A
module_512 | 37 | 37 | 1 | 5 | 6.87879628465322 | 0.00134699813356412 | 0.10312749125019 | SGCG [NAME] ADAM12 [NAME]
SIGNAL_TRANSDUCTION | 1598 | 1483 | 0.928035043804756 | 51 | 1.64945929578601 | 0.00136366031413868 | 0.103145294604369 | TACR3 DRD4 DRD5 UNQ739 TRHDE PTPRT GRM6 [NAME] ADCYAP1 GRIK3 GRIA4 ADRA1A C7orf16 MLNR HTR1B TP73 FLT4 CART VIPR2 IL20 OPRM1 DDR2 EFS NTRK1 NPY GDF10 [NAME] PENK TRH SOCS2 WISP3 CD226 NMBR F2RL3 NR1I3 GALR1 GABRG2 GABRB2 GABRB1 GABRA4 GABRA2 CDKN2A CDH13
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | 42 | 38 | 0.904761904761905 | 5 | 6.66997077829997 | 0.00152292439890524 | 0.113820468765799 | HTR2C ADRA1A HTR1B DRD4 DRD5
module_95 | 511 | 425 | 0.831702544031311 | 20 | 2.2211221480423 | 0.00155698550965174 | 0.114997117995219 | PLCD1 MYO3A HSPB2 PTPRR DGKI BHMT KCNS2 IRF4 PSCA TBX5 KCNB1 PCDHB15 GABRA2 MEGF11 KCNV1 SOX1 CDO1 CSMD3 AJAP1 CPA1
[NAME] | 516 | 428 | 0.829457364341085 | 20 | 2.20429523106403 | 0.00169189816872666 | 0.123508566317046 | PLCD1 MYO3A HSPB2 PTPRR DGKI BHMT KCNS2 IRF4 PSCA TBX5 KCNB1 PCDHB15 GABRA2 MEGF11 KCNV1 SOX1 CDO1 CSMD3 AJAP1 CPA1
TGATTTRY_V$GFI1_01 | 243 | 226 | 0.930041152263374 | 13 | 2.72100432687501 | 0.00184915542340197 | 0.131895912008212 | DRD5 PSPN ADCY8 CARD11 HOXD9 HOXD10 CD226 SIX6 [NAME] [NAME]
TRANSMISSION_OF_NERVE_IMPULSE | 187 | 173 | 0.925133689839572 | 11 | 3.0189107533975 | 0.00186739289894688 | 0.131895912008212 | HTR1B DRD4 KCNA1 NPY GRM1 KCNQ5 SLC5A7 GAD2 CART GABRB2 HTR2C
[NAME] | 24 | 24 | 1 | 4 | 8.78425306036581 | 0.00186982098896637 | 0.131895912008212 | TEK CDKN2A A2BP1 DMRT3
V$POU3F2_02 | 204 | 175 | 0.857843137254902 | 11 | 2.98167706783815 | 0.00204476965211293 | 0.142634043066278 | NPTX2 SALL3 HOXD9 HOXD10 HIST1H3C GABRG2 PCDH8 FERD3L BARHL2 ISL1 CDH13
PEPTIDE_BINDING | 82 | 80 | 0.975609756097561 | 7 | 4.23591599276163 | 0.00212788592502268 | 0.145524829439824 | TACR3 F2RL3 NMBR OPCML OPRM1 GALR1 SSTR4
NEUROPEPTIDE_HORMONE_ACTIVITY | 12 | 12 | 1 | 3 | 14.5966912514994 | 0.00213257156872631 | 0.145524829439824 | ADCYAP1 PENK NPY
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN | 226 | 151 | 0.668141592920354 | 10 | 3.14791692163874 | 0.00220528874898332 | 0.148868846947497 | PCDHGB7 ATP8A2 PCDHGB4 HIST1H4F FLJ23514 CRMP1 A2BP1 FRMPD4 PCDH11Y CDKN2A
V$ATF1_Q6 | 191 | 178 | 0.931937172774869 | 11 | 2.92749898068829 | 0.00233632034511394 | 0.154393885543424 | KCNA6 NR2E1 LOXL3 ADARB2 SOX11 HS3ST2 GABRG2 PCSK1 KCTD8 HTR2C ISL1
V$SMAD_Q6 | 191 | 178 | 0.931937172774869 | 11 | 2.92749898068829 | 0.00233632034511394 | 0.154393885543424 | IRX2 WT1 NFE2 KCNA1 [NAME] CADPS EVX1 PRX DIO3
HANN_RESISTANCE_TO_BCL2_INHIBITOR_DN | 46 | 42 | 0.91304347826087 | 5 | 5.94747342448206 | 0.00239881589217283 | 0.154445470778431 | [NAME] HSPA1A DLK1
TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY | 43 | 42 | 0.976744186046512 | 5 | 5.94747342448206 | 0.00239881589217283 | 0.154445470778431 | DDR2 EPHA5 TEK FLT4 NTRK1
V$HSF_Q6 | 143 | 128 | 0.895104895104895 | 9 | 3.35153583444026 | 0.00241678442155125 | 0.154445470778431 | HSPB2 ADCYAP1 GRIA4 MYOD1 HSPA1A GAD2 PCSK1 OLFML3 CNNM1
module_11 | 526 | 505 | 0.960076045627376 | 22 | 2.05056030015677 | 0.00243550519386184 | 0.154445470778431 | PLXNB1 AGT CNTNAP2 PCSK1 CRMP1 ACSL6 EFS CACNA1A MAGI2 EPB41L3 KAL1 NPY GAD2 NEF3 DPYSL4 OLFM1 CART GABRG2 PENK AMT SGNE1 PTPRN
module_63 | 210 | 206 | 0.980952380952381 | 12 | 2.75263875373233 | 0.00246514065970429 | 0.154761530616236 | KCNA6 KCNA1 GRIK3 GFRA1 GABRG2 KCNB2 GABRA2 DDR2 GPR75 TNFRSF1B PTPRN TEK