Spreadsheet: 4126a94b-ded9-4f69-97a9-4b1afa767147
Sheet: Sheet1

[NAME] | Database | Full size | Pathway genes in BET subnetwork | BET enrichment q-value | Pathway genes in Lung subnetwork | Lung enrichment q-value | Cytokine-related pathways used for filtering
A third proteolytic cleavage releases NICD | Reactome | 10 | APH1A, PSEN1, PSENEN | 0.0147299995039
a4b7 Integrin signaling | PID | 8 | RHOA, PTK2, PXN, ITGB1 | 0.00106705078009
a6b1 and a6b4 Integrin signaling | PID | 46 | CDH1, CD9, [NAME], EGFR, RAC1, YWHAZ, SHC1, ITGB1 | 0.00791876054924 | RXRA, AKT1, CD9, HRAS, EGFR, ERBB2, RAC1, SHC1, GRB2, MST1R, [NAME], SFN | 0.000111904774638
Abortive elongation of HIV-1 transcript in the absence of Tat | PID | 22 |  |  | COBRA1, POLR2A, POLR2E, POLR2C, GTF2F1, POLR2G | 0.0129798766226
actions of nitric oxide in the heart | PID | 42 | HSP90AA1, PRKAR1A, CAV1, VEGFA | 0.00675203838849
Activated TLR4 signalling | Reactome | 90 |  |  | IRAK1, JUN, MYD88, FOS, TMEM189-UBE2V1, IKBKB, MAPK3, RELA, RPS6KA2 | 0.00977716988666
Activation of Ca-permeable Kainate Receptor | Reactome | 12 | [NAME], [NAME], CALM3 | 0.0147299995039 | [NAME], [NAME], CALM3 | 0.00977716988666
Activation of CaMK IV | PID | 4 | CALM2, CALM3, [NAME] | 0.00579278872412 | CALM2, CALM3, [NAME] | 0.00977716988666
Activation of NMDA receptor upon glutamate binding and postsynaptic events | Reactome | 39 | [NAME], [NAME], CALM3, CREB1 | 0.0178902884005 | CALM2, HRAS, [NAME], CALM3, [NAME], RPS6KA2, RRAS | 0.000361350243226
Activation of the AP-1 family of transcription factors | Reactome | 10 |  |  | MAPK3, JUN, FOS | 0.00977716988666
Adaptive Immune System | Reactome | 508 | MAP3K7, CREB1, PTEN, UBA2, RELA, UBE2D3, CALM2, CDC42, RAC1, [NAME], UBA1, CDKN1A, ITGB1, TCEB1, TRIB3, CALM3, SHC1, [NAME], STUB1, CDH1, YWHAZ | 0.00330436188925 | AKT1, UBE2D2, SRC, TMEM189-UBE2V1, GRB2, HLA-B, CALR, CD81, HRAS, FYN, ITGB2, CD4, UBE2E3, [NAME], HLA-A, PDIA3, RELA, KEAP1, CALM2, CDC42, YWHAB, RAC1, UBA1, [NAME], CDKN1A, CALM3, SHC1, B2M, [NAME], TSC2, IKBKB, UBE2D4, UBE2Z, STUB1, ZBTB16, SEC61B | 2.57212920193e-05
Adipogenesis | Wikipathways | 130 | CTNNB1, CREB1, HIF1A, CDKN1A, TRIB3, LMNA, RB1, FAS | 0.0210599615939 | SREBF1, RXRA, MIF, RARA, STAT6, STAT5B, GATA2, CDKN1A, STAT3, NCOR2, CEBPA, CEBPB, LMNA, EPAS1, DVL1 | 0.0017511919008
agrin in postsynaptic differentiation | PID | 48 | JUN, ITGB1, PTK2, CDC42, EGFR, PXN, RAC1 | 0.00640549450674 | JUN, DVL1, MAPK3, CDC42, EGFR, PXN, SRC, RAC1 | 0.00692569044098
AhR pathway | Wikipathways | 30 | HSP90AA1, NFE2L2, EGFR, JUN, CDKN1A | 0.00545242500279
AKT phosphorylates targets in the cytosol | PID | 8 |  |  | AKT1, PDPK1, TSC2 | 0.00977716988666
Alpha 6 Beta 4 signaling pathway | Wikipathways | 31 |  |  | PRKCD, AKT1, HRAS, RHOA, SRC, MAPK3, SHC1, RAC1 | 0.00294346916819
Alpha4 [NAME] integrin signaling events | PID | 34 | PTK2, PXN, RAC1, YWHAZ, PRKAR1A, FN1, ITGB1 | 0.000394874748464 | CD81, TLN1, SRC, PXN, RAC1, CRK, FN1 | 0.00307415709423
Alpha6Beta4Integrin | NetPath | 70 |  |  | AKT1, EIF6, RHOA, SRC, FYN, VIM, [NAME], EGFR, GRB2, ERBB2, SHC1, MST1R, [NAME], SFN, PRKCD, RAC1 | 1.75802093508e-06
Alpha9 [NAME] integrin signaling events | PID | 25 | PXN, RAC1, VEGFA, FN1, ITGB1 | 0.00545242500279 | SRC, TGM2, PXN, RAC1, SAT1, FN1 | 0.00920594382689
Alzheimers Disease | Wikipathways | 79 | PSENEN, GAPDH, PSEN1, APH1A, FAS, CALM3, [NAME], [NAME] | 0.00791876054924 | TNFRSF1A, [NAME], [NAME], MAPK3, APH1A, CALM3, CAPN1, [NAME], [NAME] | 0.00255535339864
amb2 Integrin signaling | PID | 32 |  |  | TLN1, HCK, RHOA, MST1R, ITGB2, LRP1, ITGAM | 0.00524316513912
Androgen receptor signaling pathway | Wikipathways | 85 | [NAME], GNB2L1, HDAC1, PTK2, STUB1, PRDX1, [NAME], RB1, JUN, FLNA, CDC42, UBE2I, CDKN1A, RHOA, CTNNB1, RAC1, PTEN, EGFR, RELA, CREB1 | 1.21207873169e-08 | NCOR2, GNB2L1, ROCK2, CREBBP, STUB1, CAV1, SRC, JUN, CCND1, AKT1, CDC42, UBE2I, CDKN1A, RHOA, BAG1, RAC1, KAT5, STAT3, EGFR, CALR, RELA | 3.60555633563e-08
AndrogenReceptor | NetPath | 148 | JUN, [NAME], RB1, FLNA, UBE2I, EGFR, CREB1, PTEN, CAV1, HSPA4, [NAME], [NAME], GNB2L1, PRDX1, CTNNB1, HSP90AA1, PTK2, PXN, PPP1CA | 3.72675684591e-06 | AKT1, JUN, CCND1, SF1, UBE2I, [NAME], XRCC6, KAT5, BAG1, GTF2F1, [NAME], CDC25B, SRC, [NAME], CEBPA, [NAME], GNB2L1, [NAME], NCOR2, PXN, PPP1CA, STAT3, [NAME] | 1.09283929033e-07
Angiogenesis | Wikipathways | 23 | PTK2, HIF1A, VEGFA | 0.0147299995039
angiogenesis overview | Wikipathways | 63 | PXN, IQGAP1, CDC42, MAP3K7, SHC1, VEGFA, RAC1 | 0.00154345737728 | PDPK1, GRB2, PXN, KDR, CRK, AKT1, FGFR1, CDC42, SRC, SHC1, RAC1 | 0.000328805753759
Angiopoietin receptor Tie2-mediated signaling | PID | 51 | RELA, PTK2, PXN, RAC1, CDKN1A, FN1, SHC1, ITGB1 | 0.000349604158498 | AKT1, STAT5B, FYN, RELA, PXN, RAC1, CDKN1A, FN1, SHC1, GRB2, CRK, MAPK3 | 1.93342810337e-05
[NAME] mediated activation of jnk pathway via pyk2 dependent signaling | PID | 36 | JUN, EGFR, SHC1, RAC1 | 0.0178902884005 | JUN, SRC, HRAS, MAPK3, EGFR, GRB2, FOS, SHC1, RAC1 | 2.76451576682e-05
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers | Reactome | 52 | [NAME], CALM2, SHC1, CALM3 | 0.00675203838849 | [NAME], [NAME], SHC1, GRB2, CALM3 | 0.0144868510133
AP-1 transcription factor network | PID | 70 | JUN, COPS5, CTNNB1, CDKN2A, MYC, HIF1A, CREB1, PTEN, TRIP6, PLAU | 5.14045483035e-05 | HLA-A, JUN, JUNB, CCND1, FOS, GATA2, JUND, BAG1, TCF7L2, TRIP6 | 0.00218930514678
Apoptosis | Reactome | 105 | BCL2L1, MYC, JUN, CDKN2A, FAS, RELA | 0.0135851200803 | AKT1, BCL2L1, MAGED1, [NAME], PRKCD, TNFRSF1A, LMNA, [NAME], VIM, BCAP31 | 0.0122068298494
Apoptosis Modulation and Signaling | Wikipathways | 90 |  |  | IRAK1, IKBKB, MAPK3, BCL2L1, TNFRSF1A, HSPA1A, JUN, MCL1, FOS, TOLLIP, MYD88, FADD | 0.00046329154775
Arf6 signaling events | PID | 35 | EGFR, PXN, EPHA2, GNA15 | 0.0178902884005
ARMS-mediated activation | Reactome | 17 |  |  | [NAME], HRAS, MAPK3, CRK | 0.00781940027808
ATF-2 transcription factor network | PID | 63 |  |  | JUN, JUND, MAPK3, FOS, BCL2L1, CDK4, JUNB, [NAME], CCND1 | 0.00101414215318
ATM pathway | PID | 35 |  |  | CTBP1, ABL1, [NAME], TRIM28, YWHAB | 0.000512005256097
atm signaling pathway | PID | 18 | JUN, RBBP8, RELA | 0.0249198523019
Atypical NF-kappaB pathway | PID | 14 |  |  | SRC, [NAME], RELA, IKBKB | 0.00781940027808
[NAME] signaling | PID | 43 | RHOA, PSMA3, NCL, NPM1 | 0.00675203838849
Axon guidance | Reactome | 268 | RAC1, SIAH2, EGFR, CSNK2A1, PFN2, CREB1, CSNK2B, CDC42, HSP90AB1, HSP90AA1, PTK2, EZR, RHOA, ITGB1 | 0.00997094946182 | RAC1, HRAS, EGFR, [NAME], CSNK2B, CDC42, SRC, ERBB2, [NAME], ROCK2, FYN, FGFR1, DNM2, COL4A2, [NAME], GRB2, RPS6KA2, RRAS, TLN1, MAPK3, EZR, RHOA, SIAH1, MYH9, MSN | 0.000114284689704
B cell receptor signaling | INOH | 101 |  |  | PSMB3, HRAS, FYN, GRB2, [NAME], PSMB1, TMEM189-UBE2V1, IKBKB, MAPK3, RELA, SRC | 0.00977716988666
B Cell Receptor Signaling Pathway | Wikipathways | 93 | CDC42, CREB1, RAC1, MYC, JUN, RELA, SHC1, MAP3K7 | 0.00310478167011 | PDPK1, PRKCD, CDC42, CRK, HRAS, IKBKB, RAC1, GRB2, JUN, [NAME], AKT1, RELA, SHC1, FYN | 6.19681487217e-05
BARD1 signaling events | PID | 31 | PRKDC, [NAME], UBE2D3, PCNA, NPM1 | 0.0118684603594
Base Excision Repair | Wikipathways | 14 | PCNA, TDG, APEX1 | 0.0147299995039
basic mechanisms of sumoylation | PID | 6 | SUMO2, UBE2I, UBA2, [NAME] | 0.00675203838849
BCR | NetPath | 132 | [NAME], RB1, PTK2, SHC1, CREB1, RELA, MAP3K7, RPS6, CTNNB1, HNRNPK | 0.000793104235122 | JUN, [NAME], AKT1, FYN, SHC1, PRKCD, NEDD9, HCK, FOS, CRK, RELA, CD81, MAPK3, STAT3, GRB2, IKBKB, CDK4, [NAME], [NAME] | 9.46995899236e-06
bcr signaling pathway | PID | 32 | JUN, CSNK2A1, RAC1, SHC1 | 0.0118684603594 | JUN, FOS, HRAS, MAPK3, GRB2, RAC1, SHC1 | 0.000117832767738
BCR signaling pathway | PID | 70 | JUN, SHC1, [NAME], [NAME], CALM3, RAC1, RELA, MAP3K7, CSNK2A1, PTEN | 1.7129918273e-05 | AKT1, JUN, FOS, [NAME], SHC1, [NAME], MAPK3, [NAME], GRB2, CALM3, RAC1, IKBKB, RELA, HRAS | 3.9216871727e-07
bioactive peptide induced signaling pathway | PID | 33 |  |  | GNA11, STAT5B, HRAS, MAPK3, FYN, GRB2, SHC1, STAT3 | 9.92409925423e-05
C-MYB transcription factor network | PID | 85 |  |  | UBE2I, CCND1, CREBBP, CD4, TRIM28, CEBPA, CEBPB, HRAS, CDKN1A | 0.0038507955264
Ca-dependent events | Reactome | 30 | [NAME], [NAME], PRKAR1A, CALM3, CREB1 | 0.000812096613293
cadmium induces dna synthesis and proliferation in macrophages | PID | 16 |  |  | HRAS, MAPK3, JUN, RELA, FOS | 0.00510197772482
Calcineurin-regulated NFAT-dependent transcription in lymphocytes | PID | 50 |  |  | [NAME], JUN, FOS, CDK4, PTPN1, JUNB, CALM3, CALM2 | 0.000243323451392
Calcium Regulation in the Cardiac Cell | Wikipathways | 149 |  |  | PRKCD, CALR, PRKCZ, [NAME], GNAI2, GNA11, SFN, CALM3, [NAME], [NAME] | 0.0144868510133
calcium signaling by hbx of hepatitis b virus | PID | 16 | SHC1, JUN, CSNK2A1, CREB1 | 0.0118684603594 | SHC1, SRC, HRAS, MAPK3, JUN, FOS, GRB2 | 2.92217003438e-05
Calcium signaling in the CD4+ TCR pathway | PID | 29 | [NAME], [NAME], CALM3, CALM2 | 0.0178902884005 | [NAME], JUN, FOS, CALM3, JUNB, [NAME] | 0.00554461619866
Calmodulin induced events | PID | 5 | [NAME], [NAME], PRKAR1A, CALM3, CREB1 | 0.000245846377435 | [NAME], CALM3, CALM2 | 0.00977716988666
[NAME] pathway | PID | 3 | [NAME], [NAME], PRKAR1A, CALM3, CREB1 | 0.000245846377435 | CALM2, CALM3, [NAME] | 0.00977716988666
Cam-PDE 1 activation | Reactome | 6 | [NAME], [NAME], CALM3 | 0.00579278872412 | [NAME], [NAME], CALM3 | 0.00977716988666
CaMK IV-mediated phosphorylation of CREB | PID | 5 | [NAME], [NAME], CALM3, CREB1 | 0.00106705078009 | [NAME], [NAME], CALM3 | 0.00977716988666
carm1 and regulation of the estrogen receptor | PID | 12 |  |  | GTF2F1, CREBBP, POLR2A | 0.00977716988666
cbl mediated ligand-induced downregulation of egf receptors pathway | PID | 8 |  |  | SRC, EGFR, GRB2 | 0.00977716988666
[NAME] | Reactome | 32 | TRIB3, CDC42, RAC1 | 0.0249198523019 | AKT1, PDPK1, CDC42, FYN, GRB2, RAC1, SRC | 0.000117832767738
[NAME] [NAME] pathway | PID | 8 |  |  | FYN, RAC1, GRB2, CDC42 | 0.00243688506669
CD4 T cell receptor signaling | INOH | 135 |  |  | AKT1, PSMB3, JUN, [NAME], HRAS, FYN, CALM3, CD4, [NAME], FOS, RAC1, PSMD4, PSMB1, TMEM189-UBE2V1, GRB2, IKBKB, [NAME], MAPK3, RELA | 6.0405291234e-05
CD4 T cell receptor signaling-JNK cascade | INOH | 59 | CALM2, CALM3, RAC1, [NAME], [NAME] | 0.00791876054924 | CALM2, MAPK3, FOS, CALM3, RAC1, CD4, [NAME], [NAME] | 0.00950308780961
CD40/CD40L signaling | PID | 35 | JUN, BCL2L1, RELA, MYC | 0.00330436188925
CDC42 signaling events | PID | 72 |  |  | JUN, HRAS, ARHGDIA, PRKCZ, RAC1, SRC, BAIAP2, MAPK3, CDC42 | 0.00781940027808
CDO in myogenesis | Reactome | 31 | CTNNB1, CDC42, BNIP2 | 0.0249198523019
Cell cycle | Wikipathways | 102 | CDH1, CDKN1A, YWHAZ, PRKDC, YWHAQ, CDKN2A, PCNA, HDAC2, [NAME], [NAME], HDAC3 | 0.000245846377435 | ABL1, CDC25B, CDKN1A, [NAME], ARF1, CDK4 | 0.00294346916819
cell cycle: g1/s check point | PID | 26 | RB1, CDKN1A, HDAC1, CDKN2A | 0.00675203838849 | CCND1, ABL1, CDKN1A, CDK4 | 0.00781940027808
Cell death signalling via NRAGE, NRIF and NADE | Reactome | 66 | APH1A, AATF, PSENEN, RAC1, PSEN1 | 0.0118684603594
Cell surface interactions at the vascular wall | Reactome | 99 |  |  | HRAS, FYN, ITGB2, SHC1, ITGAM, PECAM1, SRC, CAV1, FN1, GRB2 | 0.0180564031563
cell to cell adhesion signaling | PID | 9 |  |  | SRC, PXN, PECAM1 | 0.00977716988666
Cellular roles of Anthrax toxin | PID | 22 |  |  | [NAME], [NAME], MAPK3, CALM3 | 0.0144868510133
Ceramide signaling pathway | PID | 48 |  |  | AKT1, RELA, TNFRSF1A, MAPK3, PRKCZ, FADD, PRKRA, PRKCD | 0.00294346916819
ceramide signaling pathway | PID | 33 |  |  | TNFRSF1A, MAPK3, RELA, IKBKB, FADD | 0.0144868510133
chaperones modulate interferon signaling pathway | PID | 15 |  |  | HSPA1A, RELA, [NAME], IKBKB | 0.00781940027808
chromatin remodeling by hswi/snf atp-dependent complexes | PID | 16 |  |  | GTF2F1, SMARCA4, ACTB, POLR2A, SMARCC2 | 0.00207046669091
Class I MHC mediated antigen processing & presentation | Reactome | 218 |  |  | B2M, UBE2E3, UBE2D2, PJA1, CALR, UBA1, HLA-A, UBE2D4, HLA-B, UBE2Z, STUB1, PDIA3, KEAP1, ZBTB16, SEC61B, TMEM189-UBE2V1 | 0.0146384995155
Class I PI3K signaling events | PID | 45 |  |  | RHOA, HCK, SRC, HRAS, FYN, ARF1, PDPK1, RAC1 | 0.00294346916819
Class I PI3K signaling events mediated by [NAME] | PID | 36 | PRKDC, YWHAQ, HSP90AA1, BCL2L1, CDKN1A, YWHAZ | 0.00238876218746 | PDPK1, AKT1, SRC, BCL2L1, CDKN1A, YWHAB, SFN | 0.00181177682958
Coregulation of Androgen receptor activity | PID | 66 | PRKDC, CTNNB1, UBE2I, HNRNPA1, CDKN2A, PRDX1 | 0.0249198523019
corticosteroids and cardioprotection | PID | 27 | ANXA1, HSP90AA1, RELA, CAV1 | 0.00675203838849
Costimulation by the CD28 family | Reactome | 84 |  |  | CD4, CDC42, AKT1, RAC1, [NAME], FYN, GRB2, SRC | 0.0149246832911
CREB phosphorylation through the activation of CaMKII | Reactome | 17 | [NAME], [NAME], CALM3, CREB1 | 0.00106705078009 | [NAME], [NAME], CALM3 | 0.00977716988666
CREB phosphorylation through the activation of CaMKK | PID | 6 | [NAME], [NAME], CALM3, CREB1 | 0.00106705078009 | [NAME], [NAME], CALM3 | 0.00977716988666
CREB phosphorylation through the activation of [NAME] | Reactome | 29 | [NAME], [NAME], CALM3, CREB1 | 0.0178902884005 | CALM2, HRAS, [NAME], CALM3, [NAME], RPS6KA2, RRAS | 0.000117832767738
ctcf: first multivalent nuclear factor | PID | 23 | PTEN, MYC, CDKN2A | 0.0249198523019
CTLA4 inhibitory signaling | Reactome | 23 |  |  | AKT1, [NAME], SRC, FYN | 0.0144868510133
CXCR3-mediated signaling events | PID | 38 |  |  | AKT1, [NAME], GNAI2, SRC, HRAS, MAPK3 | 0.00294346916819
CXCR4-mediated signaling events | PID | 89 | RAC1, PTEN, CDC42, GNB2L1, RHOA, PTK2, PXN | 0.019825434334 | AKT1, FYN, CD4, HCK, SRC, PRKCZ, RAC1, CRK, CDC42, HGS, PDPK1, GNAI2, GNB2L1, STAT5B, RHOA, PXN, STAT3 | 8.31515039956e-06
Cyclin E associated events during G1/S transition | PID | 13 | MYC, RB1, CDKN1A | 0.0249198523019
cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway | PID | 22 | PRKAR1A, EZR, SLC9A3R1 | 0.0249198523019
[NAME] in Immune system | Reactome | 186 |  |  | IRAK1, HRAS, FYN, SHC1, GRB2, PTPN1, [NAME], PRKCD, HCK, MYD88, CRK, TMEM189-UBE2V1, STAT3, IKBKB, SQSTM1, STAT5B, MAPK3, RELA, TOLLIP | 4.35546507069e-05
Cytosolic tRNA aminoacylation | PID | 24 | DARS, RARS, AIMP1, IARS, EPRS, KARS, AIMP2 | 0.0134626380933
DAG and IP3 signaling | Reactome | 33 | [NAME], [NAME], PRKAR1A, CALM3, CREB1 | 0.000812096613293
DARPP-32 events | PID | 10 | [NAME], [NAME], PRKAR1A, CALM3, PPP1CA, [NAME] | 0.000831366847649 | [NAME], PPP1CA, CALM2, CALM3 | 0.00243688506669
DCC mediated attractive signaling | Reactome | 16 | RAC1, PTK2, CDC42 | 0.0147299995039 | SRC, FYN, RAC1, CDC42 | 0.00781940027808
Destabilization of mRNA by [NAME] (hnRNP D0) | Reactome | 7 |  |  | HSPA1A, [NAME], HNRNPD, [NAME] | 0.00781940027808
Developmental Biology | Reactome | 363 | SIAH2, CSNK2A1, CTNNB1, CREB1, CSNK2B, HSP90AB1, HDAC3, RHOA, HSP90AA1, CDC42, PFN2, BNIP2, RAC1, PTK2, ITGB1, EGFR, EZR | 0.00396549110158 | AKT1, SRC, DNM2, TLN1, MSN, MAPK3, FGFR1, HRAS, FYN, SIAH1, CSNK2B, RXRA, RRAS, RHOA, NCOR2, CDC42, [NAME], [NAME], RAC1, ABL1, MYH9, CREBBP, ROCK2, EGFR, ERBB2, COL4A2, GRB2, RPS6KA2, EZR | 6.19681487217e-05
Direct p53 effectors | PID | 144 | [NAME], [NAME], EGFR, [NAME], BCL2L1, [NAME], FAS, PTEN, CAV1, CEBPZ, CSE1L, PCNA, CDKN1A, HDAC2 | 0.00137298180094 | JUN, [NAME], [NAME], BCL2L1, HSPA1A, VDR, SMARCA4, TSC2, SFN, [NAME], CAV1, PRKAB1, MCL1, CREBBP, CDKN1A | 0.0017511919008
Disease | Reactome | 395 | TAF9, PXN, PTEN, RCC1, HSP90AA1, CALM2, CDC42, CREB1, PRKAR1A, RAC1, NCBP1, SSRP1, CDKN1A, TCEB1, TRIB3, EGFR, CALM3, SHC1, [NAME], KPNB1, NPM1 | 0.00206997241178 | AKT1, GTF2F1, SRC, GRB2, TAF11, MAPK3, PXN, POLR2A, HRAS, FYN, YWHAB, ARF1, CD4, HCK, CALR, HLA-A, POLR2G, CALM2, CDC42, PRKCD, RAC1, PABPN1, COBRA1, CDKN1A, RARA, EGFR, XRCC6, CALM3, SHC1, B2M, [NAME], POLR2C, TSC2, HGS, PDPK1, POLR2E, [NAME] | 8.96311848626e-08
DNA damage response | Wikipathways | 67 |  |  | CCND1, ABL1, CDK4, SFN, RPA2, CDKN1A | 0.00920594382689
DNA damage response (only ATM dependent) | Wikipathways | 91 | MYC, CDC42, CTNNB1, HMGB1, RHOA, PLAU, RAC1, MAP3K7, JUN, CDKN1A, CDKN2A, PTEN, [NAME], SHC1 | 3.72675684591e-06 | ABL1, CDC42, ERBB2, CCND1, AKT1, DVL1, RHOA, RAC1, GRB2, JUN, CDKN1A, BCL6, [NAME], SHC1 | 2.13282763694e-06
DNA Repair | Reactome | 114 |  |  | POLR2A, RPA2, XRCC6, POLR2C, VCP, POLR2E, POLR2G | 0.0196222321142
downregulated of mta-3 in er-negative breast tumors | PID | 21 | HSPB1, CDH1, HDAC1, GAPDH | 0.0249198523019
Downstream signal transduction | Reactome | 97 | TRIB3, CALM2, PRKAR1A, CALM3, CREB1, [NAME], PTEN, CDKN1A | 0.00658208978756 | CALM2, AKT1, HRAS, [NAME], CALM3, PRKCD, [NAME], SRC, TSC2, CRK, GRB2, STAT6, [NAME], STAT5B, MAPK3, CDKN1A, STAT3 | 8.31515039956e-06
Downstream Signaling Events Of B Cell Receptor (BCR) | Reactome | 51 | TRIB3, RELA, CDKN1A, MAP3K7, CREB1, PTEN | 0.00545242500279 | AKT1, [NAME], RELA, HRAS, TSC2, CDKN1A, IKBKB | 0.00789351157551
Downstream signaling in na&#xef;ve CD8+ T cells | PID | 68 | CALM2, JUN, CALM3, [NAME] | 0.0249198523019 | CALM2, JUN, HRAS, MAPK3, HLA-A, FOS, CALM3, [NAME], JUNB, B2M | 8.31515039956e-06
Downstream signaling of activated FGFR | Reactome | 103 | TRIB3, CALM2, PRKAR1A, CREB1, CALM3, SHC1, [NAME], PTEN, CDKN1A | 0.000376258877154 | CALM2, AKT1, HRAS, CALM3, SHC1, [NAME], PRKCD, FGFR1, [NAME], TSC2, GRB2, [NAME], MAPK3, CDKN1A | 3.9600363482e-05
Downstream TCR signaling | PID | 29 |  |  | PDPK1, RELA, IKBKB, CD4, TMEM189-UBE2V1 | 0.00510197772482
E-cadherin signaling in keratinocytes | PID | 21 | RHOA, CTNNB1, CDH1, EGFR, RAC1 | 0.00791876054924 | RHOA, SRC, FYN, JUP, EGFR, RAC1, AKT1 | 0.00181177682958
E-cadherin signaling in the nascent adherens junction | PID | 39 |  |  | AKT1, CCND1, RHOA, SRC, CDC42, JUP, CRK, RAC1 | 0.00476294592179
E2F transcription factor network | PID | 77 | [NAME], RB1, CDKN2A, RBBP8, MYC, PLAU, CDKN1A | 0.00244652821517 | CEBPA, MCL1, TRIM28, CREBBP, YY1, CDKN1A | 0.0129798766226
EGF | INOH | 28 | JUN, [NAME], EGFR, YWHAZ, SHC1 | 0.0163620818244 | JUN, HRAS, EGFR, GRB2, SHC1, [NAME], SFN, MAPK3 | 3.34260462088e-05
EGF receptor (ErbB1) signaling pathway | PID | 34 |  |  | TLN1, SRC, HRAS, MAPK3, EGFR, GRB2, SHC1, PTPN1, STAT3 | 0.000152939956108
egf signaling pathway | PID | 20 |  |  | SHC1, HRAS, STAT3, GRB2, EGFR | 0.000512005256097
EGF-EGFR Signaling Pathway | Wikipathways | 141 | JUN, CDC42, EGFR, STAMBP, CREB1, PTK2, CAV1, IQGAP1, PCNA, PTEN, RAC1, SHC1 | 0.00137298180094 | PDPK1, [NAME], [NAME], PRKCD, RALGDS, CDC42, EGFR, PRKCZ, ERBB2, HGS, CRK, FOS, STAT3, STAT5B, [NAME], GRB2, JUND, RPS6KA2, AKT1, RAC1, SHC1 | 1.09283929033e-07
EGFR interacts with phospholipase C-gamma | Reactome | 35 | [NAME], [NAME], [NAME], PRKAR1A, CALM3, CREB1 | 0.000181951399867 | [NAME], [NAME], EGFR, CALM3, PRKCD | 0.0144868510133
EGFR-dependent Endothelin signaling events | PID | 9 |  |  | EDNRA, SHC1, HRAS, EGFR, GRB2 | 0.00207046669091
EGFR1 | NetPath | 462 | SDC1, PDLIM4, TRIP6, IQGAP1, FLNB, PXN, ACTB, TOLLIP, [NAME], TRIM29, [NAME], PTEN, ANXA2, RHOA, RELA, [NAME], RPLP0, JUN, CALM2, CDC42, CREB1, PRKAR1A, RAC1, CAV1, ITGA3, ANXA1, HNRNPA1, PTK2, EEF1A1, MYC, ITGB1, EGFR, CALM3, SHC1, [NAME], STAMBP, CDH1, YWHAZ, DDX3X | 1.03045864159e-05 | AKT1, [NAME], SRC, PRKCZ, CTBP1, TRIP6, GRB2, TLN1, MAPK3, PXN, ACTB, TOLLIP, HRAS, FYN, CEBPB, PRKCD, FOS, CRK, ELF3, STAT5B, RHOA, PTPRF, VIM, RELA, [NAME], STAT3, RPLP0, JUN, [NAME], RALGDS, CDC42, PTPN1, RAC1, [NAME], [NAME], JUND, BAIAP2, MYH9, EGFR, [NAME], CALM3, SHC1, [NAME], ATP1A1, ERBB2, PDCD6IP, CEBPA, HGS, VCL, [NAME], RPS6KA2, SDC4 | 3.60555633563e-08
Elongation arrest and recovery | PID | 32 |  |  | COBRA1, POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, POLR2G | 0.0105607939073
Endogenous TLR signaling | PID | 26 |  |  | IRAK1, RHOA, IKBKB, MYD88 | 0.0144868510133
Endothelin | Wikipathways | 35 | GNA15, CALM3, [NAME], [NAME] | 0.0178902884005
Endothelins | PID | 65 | JUN, RHOA, CDC42, RAC1, GNA15 | 0.0219198853134 | EDNRA, JUN, AKT1, GNA11, RHOA, SRC, HRAS, MAPK3, CDC42, GNAI2, FOS, RAC1, CRK, PRKCD, EDNRB | 8.41637705443e-06
Energy dependent regulation of mTOR by LKB1-AMPK | Reactome | 18 |  |  | RHEB, TSC2, PRKAB1 | 0.00977716988666
eNOS activation | PID | 9 | [NAME], HSP90AA1, [NAME], [NAME], CALM3, [NAME] | 5.14045483035e-05 | AKT1, [NAME], [NAME], [NAME], CALM3 | 0.000512005256097
eNOS activation and regulation | Reactome | 20 | [NAME], HSP90AA1, [NAME], [NAME], CALM3, [NAME] | 0.000181951399867 | AKT1, [NAME], [NAME], DNM2, CALM2, CALM3 | 0.00294346916819
EPHA forward signaling | PID | 34 |  |  | RHOA, HCK, SRC, FYN, CRK | 0.00207046669091
EPHA2 forward signaling | PID | 18 | RHOA, SHC1, PTK2, EPHA2, RAC1 | 0.000812096613293 | RHOA, SHC1, SRC, GRB2, RAC1 | 0.00510197772482
EPHB forward signaling | PID | 41 |  |  | SRC, HRAS, MAPK3, CDC42, GRB2, RAC1, SHC1, PXN, CRK, RRAS | 4.69482351643e-05
EPO Receptor Signaling | Wikipathways | 26 |  |  | STAT5B, GRB2, AKT1, SRC, MAPK3, STAT3, SHC1 | 0.00307415709423
EPO signaling | INOH | 184 |  |  | AKT1, IRAK1, KDR, EGFR, PRKCD, FGFR1, SRC, PRKCZ, FYN, STAT3, IKBKB, CDK4, STAT5B, PRKAB1, [NAME], MAPK3, RPS6KA2, [NAME] | 2.53062512282e-05
EPO signaling pathway | PID | 34 |  |  | STAT5B, HRAS, GRB2, BCL2L1, SHC1 | 0.00954441103043
epo signaling pathway | PID | 11 |  |  | SHC1, HRAS, STAT5B, GRB2 | 0.00781940027808
ErbB signaling pathway | Wikipathways | 54 |  |  | [NAME], GRB2, CRK, CCND1, EGFR, HRAS, JUN, SRC, CDKN1A, ERBB2 | 9.92409925423e-05
ErbB1 downstream signaling | PID | 108 | JUN, [NAME], CDC42, EGFR, BCL2L1, CALM3, CREB1, [NAME], YWHAQ, RAC1, [NAME], RPS6, IQGAP1, YWHAZ | 0.000328233028627 | AKT1, JUN, [NAME], HRAS, RALGDS, CDC42, EGFR, BCL2L1, [NAME], CALM3, SMAD1, PRKCD, [NAME], SRC, FOS, PRKCZ, RAC1, SFN, STAT3, GRB2, PDPK1, BAIAP2, MAPK3 | 3.60555633563e-08
ErbB2/ErbB3 signaling events | PID | 42 |  |  | AKT1, SHC1, SRC, HRAS, MAPK3, CDC42, ERBB2, FOS, RAC1, JUN, GRB2, STAT3 | 5.65625954397e-07
ErbB4 signaling events | PID | 31 |  |  | STAT5B, MAPK3, FYN, GRB2, ERBB2, SHC1 | 0.0014466921551
erk and pi-3 kinase are necessary for collagen binding in corneal epithelia | PID | 32 |  |  | TLN1, RHOA, SRC, MAPK3, PXN, VCL, CAPN1 | 0.00789351157551
[NAME]/erk2 mapk signaling pathway | PID | 22 |  |  | TERT, SRC, HRAS, MAPK3, GRB2, SHC1, STAT3 | 0.00181177682958
erythropoietin mediated neuroprotection through nf-kb | PID | 13 | JUN, RELA, HIF1A, COPS5, CDKN1A, CREB1 | 5.14045483035e-05
Eukaryotic Translation Elongation | PID | 7 | EEF1A1, EEF1B2, EEF1D, EEF1G | 0.00106705078009
FAS (CD95) signaling pathway | PID | 35 |  |  | AKT1, [NAME], SRC, IKBKB, EZR, FADD | 0.000510480405482
FAS pathway and Stress induction of HSP regulation | Wikipathways | 38 | LMNA, FAS, RB1, MAP3K7, JUN, [NAME], PRKDC | 0.00106705078009
fas signaling pathway (cd95) | PID | 20 | RB1, FAS, PRKDC, MAP3K7 | 0.0118684603594
fc epsilon receptor i signaling in mast cells | PID | 29 |  |  | JUN, HRAS, MAPK3, GRB2, FOS, SHC1 | 0.0014466921551
Fc-epsilon receptor I signaling in mast cells | PID | 64 | PTK2, JUN, RELA, PXN, SHC1 | 0.0118684603594 | AKT1, JUN, HRAS, FYN, RELA, PXN, FOS, SHC1, GRB2, IKBKB, MAPK3 | 0.000186512042959
FGF | INOH | 67 |  |  | FGFR1, MAPK3, GRB2, [NAME], SFN, HRAS, PRKCD | 0.0105607939073
FGF signaling pathway | PID | 51 |  |  | FGFR1, SRC, STAT5B, AKT1, GRB2, FOS, JUN, SHC1, [NAME], MAPK3 | 0.00053353335503
Focal Adhesion | Wikipathways | 184 | PTK2, PXN, CDC42, FLNA, ITGA3, RHOA, RAC1, ACTB, CAV1, JUN, ITGB1, PTEN, FN1, SHC1, EGFR | 0.00244757150618 | PDPK1, ROCK2, VWF, PXN, KDR, CRK, CDC42, SRC, ERBB2, CAPN1, CCND1, AKT1, RHOA, RAC1, ILK, ACTB, MYL6, TLN1, CAV1, GRB2, VCL, JUN, ITGB2, ITGAM, ACTG1, HCK, COL4A2, FN1, SHC1, EGFR, FYN | 3.9216871727e-07
Formation of HIV-1 elongation complex containing HIV-1 Tat | PID | 43 |  |  | POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, COBRA1, POLR2G | 0.0105607939073
Formation of HIV-1 elongation complex in the absence of HIV-1 Tat | PID | 44 |  |  | POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, COBRA1, POLR2G | 0.0105607939073
Formation of RNA Pol II elongation complex | PID | 44 |  |  | POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, COBRA1, POLR2G | 0.0105607939073
Formation of RNA Pol II elongation complex | Reactome | 45 |  |  | COBRA1, POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, POLR2G | 0.0144868510133
Formation of the Early Elongation Complex | PID | 32 |  |  | POLR2A, POLR2E, POLR2C, GTF2F1, COBRA1, POLR2G | 0.0129798766226
Formation of the HIV-1 Early Elongation Complex | PID | 32 |  |  | POLR2A, POLR2E, POLR2C, GTF2F1, COBRA1, POLR2G | 0.0129798766226
FOXM1 transcription factor network | PID | 42 |  |  | CCND1, CREBBP, CDC25B, HSPA1A, CDK4, FOS, [NAME] | 0.00524316513912
FoxO family signaling | PID | 50 |  |  | CREBBP, BCL6, AKT1, IKBKB, [NAME], SFN | 0.0129798766226
Frs2-mediated activation | Reactome | 18 |  |  | [NAME], HRAS, MAPK3, CRK | 0.00781940027808
FRS2-mediated cascade | Reactome | 39 |  |  | FGFR1, MAPK3, HRAS, GRB2, [NAME] | 0.00510197772482
FSH signaling pathway | Wikipathways | 27 |  |  | TSC2, RHEB, AKT1, SRC, MAPK3 | 0.00510197772482
G Protein Signaling Pathways | Wikipathways | 92 |  |  | PRKCD, PRKCZ, GNA11, AKAP2, RHOA, HRAS, GNAI2, [NAME], [NAME] | 0.0149246832911
G-protein mediated events | Reactome | 46 | [NAME], [NAME], PRKAR1A, CALM3, CREB1 | 0.00791876054924
G1 to S cell cycle control | Wikipathways | 68 | PCNA, [NAME], RB1, MYC, CDKN1A, [NAME], CDKN2A, CREB1 | 0.000831366847649 | CCND1, CREB3, CDK4, RPA2, CDKN1A | 0.00954441103043
G13 Signaling Pathway | Wikipathways | 37 | IQGAP1, CDC42, RHOA, [NAME], RAC1 | 0.00791876054924 | ROCK2, CDC42, RHOA, [NAME], RAC1 | 0.00954441103043
Gab1 signalosome | PID | 12 |  |  | SRC, GRB2, EGFR, PXN | 0.00243688506669
GAB1 signalosome | Reactome | 40 | TRIB3, EGFR, PXN, CDKN1A, CREB1, PTEN | 0.000831366847649 | AKT1, [NAME], SRC, EGFR, PXN, CDKN1A, GRB2, TSC2 | 0.00101414215318
[NAME] | Reactome | 994 | KARS, TAF9, RPS7, SNRPB, ANP32A, EEF1B2, EXOSC4, [NAME], RPL22, CLNS1A, HNRNPU, AIMP2, [NAME], [NAME], EEF1D, IARS, RPS6, [NAME], RPL15, RPLP0, [NAME], [NAME], RPS3A, [NAME], RPS3, [NAME], [NAME], HNRNPA2B1, NCBP1, HNRNPA1, SSRP1, RARS, EEF1A1, AIMP1, HNRNPK, [NAME], TCEB1, [NAME], EPRS, YBX1, RPS19, EEF1G, [NAME], RPL6 | 0.0107542500837 | AKT1, TRIM28, QARS, GTF2F1, EDC4, RPS14, UPF1, MAPK3, FAU, TAF11, CASC3, RPL28, AIMP2, [NAME], PRPF6, EEF1D, HSPA1A, SNRPA, [NAME], RPLP0, POLR2G, [NAME], PRKCD, RXRA, VDR, CD2BP2, PABPN1, POLR2A, SF3B4, [NAME], RPS17, CREBBP, RPL18, RARA, RPL13, HNRNPM, RPL10, POLR2C, EEF1G, RPS8, HNRNPD, [NAME], RPS13, POLR2E, SEC61B, [NAME], COBRA1 | 0.00509413044717
Glucocorticoid receptor regulatory network | PID | 80 | HSP90AA1, JUN, HDAC1, RELA, CREB1, SUMO2, HDAC2, CDKN1A | 0.00310478167011 | SMARCA4, JUN, SFN, CREBBP, AKT1, MAPK3, RELA, FOS, STAT5B, CDKN1A, SMARCC2 | 0.000186512042959
GMCSF-mediated signaling events | PID | 38 |  |  | STAT5B, SHC1, STAT3, HRAS, IKBKB, FOS, GRB2, MAPK3 | 0.000243323451392
GPVI-mediated activation cascade | Reactome | 34 | CDC42, RHOA, RAC1 | 0.0249198523019 | AKT1, PDPK1, CDC42, RHOA, FYN, PRKCZ, RAC1 | 0.00524316513912
GRB2 events in EGFR signaling | Reactome | 14 |  |  | EGFR, HRAS, MAPK3, GRB2, [NAME] | 0.00207046669091
GRB2 events in ERBB2 signaling | Reactome | 23 |  |  | HRAS, MAPK3, EGFR, GRB2, ERBB2, YWHAB | 0.0014466921551
Grb2:SOS provides linkage to MAPK signaling for [NAME] | PID | 8 |  |  | SRC, GRB2, TLN1 | 0.00977716988666
GRB2:SOS provides linkage to MAPK signaling for [NAME] | Reactome | 15 |  |  | GRB2, VWF, FN1, TLN1, SRC | 0.000512005256097
Hemostasis | Reactome | 471 | FN1, RHOA, HDAC1, VEGFA, CALM2, CDC42, RAC1, CD9, PRKAR1A, [NAME], [NAME], PLAU, ITGA3, PTK2, ITGB1, FLNA, CALM3, SHC1, GNA15, [NAME], YWHAZ, HDAC2 | 0.00213485479104 | AKT1, ITGAM, PECAM1, SRC, PRKCZ, FN1, GRB2, ITGB2, TLN1, MAPK3, A2M, RHOA, GNA11, HRAS, FYN, LAMP2, CRK, GATA2, VWF, CALM2, CDC42, PTPN1, PRKCD, RAC1, CD9, [NAME], [NAME], CALM3, SHC1, [NAME], CLU, VCL, [NAME], GNAI2 | 0.000302149891947
HGF | INOH | 36 |  |  | SRC, HRAS, GRB2, RAC1, SHC1, CRK, MAPK3 | 0.000361350243226
HIF-1-alpha transcription factor network | PID | 66 | JUN, COPS5, CREB1, NPM1, HIF1A, NT5E, BHLHE40, VEGFA | 0.0054006061274 | JUN, ITGB2, MCL1, AKT1, CREBBP, PFKL, GATA2, HMOX1, FOS, TERT, BHLHE40 | 0.00181246075905
HIV Infection | Reactome | 161 |  |  | RARA, POLR2A, FYN, XRCC6, ARF1, COBRA1, CD4, POLR2C, GTF2F1, B2M, HCK, RAC1, HLA-A, TAF11, POLR2E, [NAME], POLR2G | 0.000169598855673
HIV Life Cycle | Reactome | 113 |  |  | POLR2A, XRCC6, CD4, POLR2C, GTF2F1, TAF11, POLR2E, CDK9, COBRA1, POLR2G | 0.00603738109912
HIV-1 elongation arrest and recovery | PID | 32 |  |  | COBRA1, POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, POLR2G | 0.0105607939073
[NAME] negative effector of fas and tnf | PID | 54 | FAS, RB1, PRKDC, LMNA, PTK2, RELA, PSEN1 | 0.000394874748464
HIV-1 Transcription Elongation | PID | 32 |  |  | POLR2A, POLR2E, POLR2C, GTF2F1, COBRA1, POLR2G | 0.0129798766226
HIV-1 Transcription Initiation | PID | 40 |  |  | POLR2A, TAF11, POLR2E, POLR2C, GTF2F1, POLR2G | 0.0179633317051
Host Interactions of HIV factors | Reactome | 94 |  |  | RARA, FYN, ARF1, CD4, B2M, HCK, RAC1, HLA-A, [NAME] | 0.0038507955264
human cytomegalovirus and map kinase pathways | PID | 16 | RB1, RELA, CREB1 | 0.0249198523019 | MAPK3, RELA, [NAME], AKT1 | 0.00781940027808
hypoxia and p53 in the cardiovascular system | PID | 22 |  |  | AKT1, HSPA1A, CDKN1A, [NAME] | 0.0144868510133
hypoxia-inducible factor in the cardivascular system | PID | 16 | JUN, HSP90AA1, HIF1A, VEGFA, COPS5, CREB1 | 0.00137034443883
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | PID | 20 | HSP90AA1, [NAME], CDKN2A, GNB2L1, COPS5, TCEB1 | 0.000831366847649
IFN-gamma pathway | PID | 45 |  |  | AKT1, [NAME], [NAME], CREBBP, CALM3, CEBPB, PRKCD, MAPK3 | 0.00182149911501
IGF signaling | INOH | 36 |  |  | AKT1, [NAME], HRAS, MAPK3, GRB2, SHC1 | 0.00920594382689
igf-1 signaling pathway | PID | 22 |  |  | JUN, HRAS, MAPK3, GRB2, FOS, SHC1 | 0.000510480405482
IGF1 pathway | PID | 32 | PTK2, YWHAZ, SHC1, PXN, GNB2L1 | 0.0118684603594 | AKT1, [NAME], HRAS, GRB2, PRKCZ, SHC1, PXN, PTPN1, CRK, PRKCD, GNB2L1 | 1.44565862173e-05
il 2 signaling pathway | PID | 15 |  |  | SHC1, HRAS, STAT5B, GRB2 | 0.00243688506669
il 3 signaling pathway | PID | 12 |  |  | SHC1, HRAS, FOS, STAT5B, GRB2 | 0.00510197772482
il 6 signaling pathway | PID | 15 |  |  | GRB2, SHC1, HRAS, CEBPB, STAT3 | 0.000512005256097
IL-1 JNK | INOH | 62 |  |  | PSMB3, IRAK1, JUN, MYD88, PSMB1, PSMD4, TOLLIP, TMEM189-UBE2V1 | 0.0196632428826
IL-1 NFkB | INOH | 64 |  |  | JUN, PSMB3, PSMD4, TOLLIP, MYD88, IKBKB, IRAK1, RELA, PSMB1, TMEM189-UBE2V1 | 0.00603738109912
IL-1 signaling pathway | Wikipathways | 51 | TOLLIP, JUN, IL1RAP, MAP3K7, RELA | 0.0219198853134 | TOLLIP, IRAK1, MYD88, JUN, IKBKB, AKT1, MAPK3, PRKCZ, SQSTM1, RELA | 9.92409925423e-05 | filter
il-2 receptor beta chain in t cell activation | PID | 53 | FAS, RB1, SHC1, BCL2L1, PCNA | 0.0258973656068 | AKT1, [NAME], STAT5B, CCND1, SHC1, HRAS, MAPK3, GRB2, FOS, BCL2L1 | 9.92409925423e-05 | filter
IL-2 Signaling pathway | Wikipathways | 42 |  |  | GRB2, AKT1, HRAS, JUN, MAPK3, STAT3, STAT5B, SHC1, FOS, FYN | 9.92409925423e-05
IL-3 Signaling Pathway | Wikipathways | 45 | YWHAQ, SHC1, BCL2L1, JUN | 0.0249198523019 | AKT1, GRB2, SHC1, BCL2L1, HRAS, JUN, SRC, HCK, MAPK3, STAT5B, STAT3, FOS, FYN | 1.4091984634e-06 | filter
IL-4 signaling pathway | Wikipathways | 53 |  |  | NFIL3, CEBPA, CEBPB, IKBKB, GRB2, AKT1, STAT6, MAPK3, STAT3, STAT5B, SHC1, FOS, RELA | 3.97790018897e-05
IL-5 signaling pathway | Wikipathways | 40 | RPS6, JUN, SHC1, MYC | 0.0249198523019 | GRB2, AKT1, JUN, MAPK3, STAT3, STAT5B, SHC1, FOS | 0.000512005256097 | filter
IL-6 signaling pathway | Wikipathways | 42 |  |  | PRKCD, GRB2, A2M, BCL2L1, AKT1, JUNB, HCK, CREBBP, MAPK3, STAT3, SHC1, RAC1 | 9.22018027306e-06
IL-7 | NetPath | 28 |  |  | AKT1, STAT5B, STAT3, FYN, SHC1, MAPK3 | 0.00920594382689
il-7 signal transduction | PID | 16 |  |  | FYN, STAT5B, CREBBP | 0.00977716988666
IL-7 signaling | INOH | 184 |  |  | AKT1, IRAK1, KDR, EGFR, PRKCD, FGFR1, SRC, PRKCZ, FYN, IKBKB, CDK4, STAT5B, PRKAB1, [NAME], MAPK3, RPS6KA2, [NAME] | 6.19681487217e-05
IL-7 signaling pathway | Wikipathways | 25 |  |  | CCND1, BCL2L1, AKT1, MAPK3, STAT3, STAT5B, FYN | 0.000117832767738
IL-9 signaling pathway | Wikipathways | 17 |  |  | [NAME], MAPK3, GRB2, STAT3, STAT5B | 0.00207046669091
IL1 | NetPath | 56 | [NAME], RB1, RELA, MAP3K7, TOLLIP, IL1RAP | 0.0171663609324 | SQSTM1, AKT1, JUN, MAPK3, MYD88, RELA, IKBKB, IRAK1, TOLLIP, TMEM189-UBE2V1 | 4.69482351643e-05 | filter
IL1-mediated signaling events | PID | 38 | JUN, RELA, MAP3K7, TOLLIP, IL1RAP | 0.0258973656068 | SQSTM1, IRAK1, JUN, MYD88, RELA, IKBKB, TOLLIP, PRKCZ, TMEM189-UBE2V1 | 2.76451576682e-05 | filter
IL12-mediated signaling events | PID | 64 |  |  | HLA-A, FOS, RELA, CD4, STAT3, STAT6, B2M | 0.0144868510133
IL17 signaling pathway | Wikipathways | 31 |  |  | CEBPB, AKT1, IKBKB, MAPK3, STAT3, RELA | 0.0014466921551
IL2 | NetPath | 78 | CREB1, JUN, RPS6, RELA, HSP90AA1, [NAME], SHC1 | 0.00640549450674 | AKT1, JUN, RELA, CRK, MAPK3, FYN, STAT3, GRB2, SHC1, TERT, PRKCZ, STAT5B | 0.000298134142131 | filter
IL2 signaling events mediated by PI3K | PID | 39 | [NAME], RPS6, CALM2, HSP90AA1, RELA, BCL2L1, CALM3, RAC1, SHC1, MYC | 1.9765963853e-06 | AKT1, [NAME], TERT, [NAME], RELA, GRB2, BCL2L1, CALM3, RAC1, SHC1, PRKCZ | 2.21408636791e-06 | filter
IL2 signaling events mediated by STAT5 | PID | 32 | BCL2L1, SHC1, MYC | 0.0249198523019 | STAT5B, GRB2, BCL2L1, SHC1 | 0.0144868510133 | filter
IL2-mediated signaling events | PID | 56 |  |  | JUN, STAT5B, STAT3, HRAS, FYN, GRB2, MAPK3, FOS, RHOA, SHC1 | 0.000933780882998
IL3 | NetPath | 52 |  |  | AKT1, STAT5B, HRAS, MAPK3, GRB2, [NAME], SHC1, CRK, GNB2L1 | 0.00174134344484
IL3-mediated signaling events | PID | 29 | HDAC1, SHC1, BCL2L1, YWHAZ | 0.0118684603594 | SHC1, GRB2, BCL2L1, STAT5B, CEBPB | 0.0144868510133 | filter
IL4 | NetPath | 65 |  |  | AKT1, CEBPA, STAT5B, CREBBP, MAPK3, GRB2, IKBKB, SHC1, STAT3, PRKCZ, STAT6, PRKCD, CEBPB | 6.55346776519e-05
IL4-mediated signaling events | PID | 66 |  |  | STAT6, AKT1, BCL6, GRB2, BCL2L1, SHC1, STAT5B, CEBPB | 0.00950308780961
IL5 | NetPath | 49 | JUN, CTNNB1, YWHAZ, SHC1, GNB2L1 | 0.0163620818244 | JUN, DNM2, HRAS, GRB2, SHC1, STAT3, STAT5B, HCK, GNB2L1, PRKCD | 0.00053353335503 | filter
IL6 | NetPath | 78 | JUN, [NAME], RB1, HSP90AA1, [NAME], RAC1, SHC1, HNRNPA1, MAP3K7 | 0.000245846377435 | AKT1, JUN, FOS, CREBBP, HCK, HRAS, FYN, [NAME], ERBB2, RAC1, SHC1, GRB2, STAT3, STAT5B, [NAME], [NAME], CEBPB, MAPK3 | 3.60555633563e-08 | filter
IL6-mediated signaling events | PID | 48 | JUN, BCL2L1, RAC1, MYC | 0.0249198523019 | AKT1, JUN, MCL1, STAT3, HCK, GRB2, FOS, BCL2L1, RAC1, A2M, JUNB, [NAME], CEBPB | 7.31146350235e-06 | filter
IL9 | NetPath | 13 |  |  | STAT6, MAPK3, STAT5B, [NAME], STAT3 | 0.000512005256097
Immune System | Reactome | 846 | BCL2L1, [NAME], MAP3K7, FLNB, HMGB1, TOLLIP, CREB1, IL1RAP, PTEN, UBA2, RELA, UBE2D3, JUN, CALM2, CDC42, TXN, RAC1, [NAME], UBA1, CDKN1A, ITGB1, TCEB1, TRIB3, CALM3, SHC1, [NAME], STUB1, CDH1, HSP90AB1, YWHAZ | 0.00137034443883 | AKT1, BCL2L1, UBE2D2, TMEM189-UBE2V1, HLA-B, ITGB2, SQSTM1, MAPK3, TOLLIP, CALR, HRAS, GRB2, CD4, UBE2E3, UBE2Z, HCK, PJA1, FOS, CRK, HLA-A, STAT5B, PDIA3, RELA, SRC, KEAP1, JUN, CALM2, CDC42, PTPN1, [NAME], [NAME], MYD88, RAC1, [NAME], FYN, UBA1, [NAME], CREBBP, CDKN1A, IRAK1, CALM3, SHC1, B2M, [NAME], TSC2, CD81, STAT3, IKBKB, UBE2D4, STUB1, ZBTB16, SEC61B, RPS6KA2 | 2.40894913535e-06 | filter
inactivation of gsk3 by [NAME] causes accumulation of b-catenin in alveolar macrophages | PID | 40 | CTNNB1, RELA, CSNK2A1, TOLLIP | 0.0249198523019 | AKT1, IRAK1, PDPK1, CCND1, DVL1, MYD88, RELA, IKBKB, [NAME], TOLLIP | 9.92409925423e-05
Inflammasomes | Reactome | 16 | HSP90AB1, TXN, BCL2L1 | 0.0147299995039
influence of ras and rho proteins on g1 to s transition | PID | 29 | RB1, RHOA, RELA, RAC1, CDKN1A | 0.00545242500279 | AKT1, PDPK1, CCND1, RHOA, HRAS, MAPK3, RELA, IKBKB, RAC1, CDKN1A, CDK4 | 2.21408636791e-06
Influenza Infection | Reactome | 54 |  |  | POLR2A, POLR2E, CALR, POLR2C, GTF2F1, PABPN1, POLR2G | 0.0105607939073
Influenza Life Cycle | Reactome | 49 |  |  | POLR2A, POLR2E, CALR, POLR2C, GTF2F1, POLR2G | 0.0129798766226
Influenza Viral RNA Transcription and Replication | Reactome | 14 |  |  | POLR2E, POLR2C, GTF2F1, POLR2G, POLR2A | 0.0144868510133
inhibition of cellular proliferation by gleevec | PID | 22 |  |  | AKT1, JUN, STAT5B, HRAS, MAPK3, GRB2, FOS | 0.000117832767738
insulin | INOH | 79 |  |  | PRKAB1, AKT1, RHEB, HRAS, GRB2, SHC1, PDPK1, TSC2, [NAME], SFN, MAPK3 | 0.000512005256097
insulin Mam | INOH | 83 |  |  | AKT1, HRAS, MAPK3, RHEB, GRB2, SHC1, PDPK1, TSC2, [NAME], SFN, PRKAB1 | 0.000801556972599
[NAME] | PID | 48 |  |  | AKT1, [NAME], HRAS, GRB2, TRIP10, PRKCZ, SHC1, PTPN1, CRK, CAV1 | 0.00053353335503
Insulin receptor signalling cascade | Reactome | 90 |  |  | HRAS, SHC1, [NAME], FGFR1, RHEB, TSC2, CRK, GRB2, PRKAB1, [NAME], MAPK3 | 0.000328805753759
[NAME] | Wikipathways | 160 |  |  | PDPK1, PRKCD, RHEB, PRKCZ, MAPK3, ARF1, TSC2, CRK, HRAS, PTPN1, IKBKB, RAC1, GRB2, RAB4A, JUN, RPS6KA2, PTPRF, FOS, PFKL, AKT1, SHC1 | 3.95541581104e-05
insulin signaling pathway | PID | 13 |  |  | SHC1, HRAS, GRB2 | 0.00977716988666
Insulin-mediated glucose transport | PID | 31 | [NAME], [NAME], YWHAQ, CALM3, YWHAZ | 0.0258973656068 | AKT1, [NAME], [NAME], TRIP10, PRKCZ, CALM3, [NAME], SFN | 3.34260462088e-05
Integrated Breast Cancer Pathway | Wikipathways | 152 | CDC42, CTNNB1, CREB1, ANXA1, VEGFA, RAC1, MYC, JUN, HDAC1, PTEN, RB1, CDH1, EGFR | 0.000394874748464 | ABL1, RHEB, CDC25B, CDC42, CCND1, TSC2, CDK4, RAC1, FAU, [NAME], [NAME], GRN, PHB, SMAD1, SMARCA4, AKT1, EGFR, RRAS | 1.10373058873e-05
Integrin | INOH | 125 | SDC1, SHC1, CDC42, RAC1, [NAME], FN1, ACTB, ITGA3, RHOA, PTK2, PXN, ITGB1 | 0.001116298462 | HRAS, FYN, SHC1, ITGAM, CDC42, SRC, RAC1, CRK, CAV1, FN1, ACTB, COL4A2, GRB2, VCL, ITGB2, TLN1, RHOA, MAPK3, PXN, SDC4 | 2.53062512282e-05
Integrin alphaIIb beta3 signaling | Reactome | 27 | PTK2, SHC1, FN1 | 0.0249198523019 | AKT1, VWF, [NAME], TLN1, SRC, GRB2, SHC1, PTPN1, CRK, FN1 | 4.19911282939e-07
Integrin alphaIIbbeta3 signaling | PID | 9 |  |  | SHC1, PTPN1, SRC, TLN1 | 0.00243688506669
Integrin cell surface interactions | Reactome | 85 |  |  | AKT1, VWF, [NAME], COL4A2, TLN1, CRK, ITGAM, SRC, GRB2, SHC1, PTPN1, ITGB2, PECAM1, FN1 | 0.000625275031125
[NAME] pathway | PID | 34 | [NAME], RHOA, PTK2, SHC1, PXN, ITGB1 | 0.0135851200803 | TLN1, CAV1, RHOA, SRC, HRAS, FYN, GRB2, SHC1, PXN, VCL, LRPAP1, CAPN1 | 9.22018027306e-06
Integrin-linked kinase signaling | PID | 46 | HSP90AA1, JUN, CTNNB1, CDC42, PXN, RAC1, CREB1, IQGAP1, [NAME] | 0.000245846377435
Integrin-mediated cell adhesion | Wikipathways | 99 | PTK2, PXN, CDC42, ITGA3, RAC1, CAV1, ITGB1, SHC1 | 0.0249198523019 | PDPK1, ROCK2, PXN, CRK, CDC42, SRC, CAPN1, HRAS, RAC1, ILK, TLN1, CAV1, GRB2, VCL, ITGB2, ITGAM, AKT1, SHC1, FYN | 1.92377952317e-06
Integrins in angiogenesis | PID | 65 | SDC1, HSP90AA1, PTK2, PXN, RAC1, RHOA, VEGFA, FN1 | 0.00219870730442 | KDR, TLN1, AKT1, SRC, PXN, RAC1, RHOA, VCL, ILK, FN1, MAPK3 | 0.00181246075905
Interleukin-1 signaling | PID | 31 |  |  | SQSTM1, IRAK1, TOLLIP, MYD88, IKBKB, TMEM189-UBE2V1 | 0.00294346916819
Interleukin-2 signaling | Reactome | 43 |  |  | STAT5B, [NAME], HRAS, MAPK3, SHC1, GRB2 | 0.00554461619866
[NAME], 5 and GM-CSF signaling | Reactome | 47 |  |  | FYN, STAT5B, SHC1, CRK, HCK, HRAS, GRB2 | 0.000874615862318
Internalization of ErbB1 | PID | 39 | STAMBP, CDC42, EGFR, PTK2, SHC1, VPS24, UBE2D3 | 0.00106705078009 | UBE2D2, SRC, HRAS, CDC42, EGFR, GRB2, SHC1, HGS | 0.000243323451392
Ionotropic activity of Kainate Receptors | Reactome | 12 | [NAME], [NAME], CALM3 | 0.0147299995039 | [NAME], [NAME], CALM3 | 0.00977716988666
IRS-mediated signalling | Reactome | 85 |  |  | FGFR1, [NAME], RHEB, [NAME], [NAME], HRAS, GRB2, TSC2, PRKAB1 | 0.00174134344484
IRS-related events | Reactome | 85 |  |  | FGFR1, [NAME], RHEB, [NAME], [NAME], HRAS, GRB2, TSC2, PRKAB1 | 0.00174134344484
JAK STAT pathway and regulation | INOH | 309 |  |  | AKT1, IRAK1, KDR, STAT6, EGFR, PSMB3, GRB2, PRKCD, FGFR1, SRC, PRKCZ, PSMB1, HRAS, FYN, PSMD4, STAT3, IKBKB, CDK4, STAT5B, PRKAB1, [NAME], MAPK3, RPS6KA2, [NAME] | 9.92409925423e-05
Keap1-Nrf2 Pathway | Wikipathways | 14 |  |  | CEBPB, KEAP1, AIMP2, HMOX1 | 0.00781940027808
[NAME] differentiation | PID | 53 | JUN, RELA, EGFR, SHC1, FAS | 0.0118684603594 | CEBPA, JUN, TNFRSF1A, MAPK3, RELA, EGFR, GRB2, IKBKB, FOS, SHC1, PRKCD, HRAS | 1.93342810337e-05
Kit receptor signaling pathway | Wikipathways | 55 |  |  | SRC, CRK, AKT1, HRAS, JUNB, MAPK3, STAT3, STAT5B, SHC1, FOS | 0.000933780882998
KitReceptor | NetPath | 67 |  |  | JUN, STAT5B, HCK, SRC, FYN, RELA, [NAME], STAT3, GRB2, SHC1, CRK, HRAS | 1.93342810337e-05
L1CAM interactions | Reactome | 97 |  |  | EGFR, EZR, CSNK2B, FGFR1, SRC, RAC1, DNM2, MAPK3, RPS6KA2, MSN | 0.00150584710857
Late Phase of HIV Life Cycle | Reactome | 95 |  |  | POLR2A, COBRA1, POLR2C, GTF2F1, TAF11, POLR2E, [NAME], POLR2G | 0.0196632428826
[NAME] | NetPath | 64 |  |  | AKT1, SRC, MAPK3, FYN, EGFR, GRB2, ERBB2, IKBKB, SHC1, STAT3, RPS6KA2, PRKCD | 0.000182265270316
Leptin signaling pathway | Wikipathways | 61 | BCL2L1, CDC42, RHOA, RAC1, SHC1, RPS6, CREB1, RELA | 0.00106705078009 | CCND1, BCL2L1, PTPN1, IKBKB, GRB2, AKT1, CDC42, HRAS, RHOA, SRC, MAPK3, RAC1, STAT3, STAT5B, SHC1, RELA, ERBB2, FYN | 3.60555633563e-08
LIF signaling | INOH | 10 |  |  | CREBBP, SMAD1, STAT3 | 0.00977716988666
links between pyk2 and map kinases | PID | 26 |  |  | JUN, SRC, HRAS, MAPK3, GRB2, SHC1, RAC1 | 0.000361350243226
Lissencephaly gene ([NAME]) in neuronal migration and development | PID | 33 | [NAME], [NAME], RHOA, CSNK2A1, CALM3, RAC1, IQGAP1, PAFAH1B1, CDC42 | 0.000109070527815 | [NAME], [NAME], RHOA, NUDC, ABL1, CALM3, RAC1, LRPAP1, CDC42 | 7.15287723141e-05
LKB1 signaling events | PID | 45 | YWHAZ, HSP90AA1, EZR, YWHAQ, CREB1, MYC | 0.00545242500279
LPA receptor mediated events | PID | 63 | JUN, TRIP6, RHOA, EGFR, PXN, RAC1, RELA, PTK2, GNA15 | 0.000573450381948 | GNAI2, GNA11, JUN, TRIP6, AKT1, RHOA, SRC, HRAS, EGFR, PXN, FOS, RAC1, RELA, CRK, PRKCD | 5.19246784058e-06
map kinase inactivation of smrt corepressor | PID | 12 | EGFR, SHC1, RAC1 | 0.0249198523019 | EGFR, SHC1, HRAS, NCOR2, GRB2, RAC1 | 0.000117832767738
MAPK Cascade | Wikipathways | 29 |  |  | JUN, HRAS, MAPK3, RRAS | 0.0144868510133
MAPK signaling pathway | Wikipathways | 160 | JUN, CDC42, FLNA, [NAME], RAC1, ATF4, MAP3K7, MYC, FAS, EGFR | 0.00791876054924 | JUN, [NAME], CDC25B, CDC42, MAPK3, PRKCZ, CRK, [NAME], IKBKB, RAC1, GRB2, ATF4, JUND, FOS, HSPA1A, AKT1, EGFR | 0.000117832767738
mapkinase signaling pathway | PID | 58 | JUN, CREB1, MAP3K7, MYC, RAC1 | 0.0118684603594 | CEBPA, JUN, HRAS, MAPK3, IKBKB, FOS, RAC1 | 0.00524316513912
mcalpain and friends in cell motility | PID | 30 | SHC1, EGFR, PTK2, PRKAR1A, RAC1, EZR, PXN, ITGB1 | 0.000556747465091 | SHC1, TLN1, HRAS, MAPK3, EGFR, GRB2, RAC1, EZR, PXN, CAPN1 | 9.92409925423e-05
mechanism of gene regulation by peroxisome proliferators via ppara | PID | 52 | [NAME], RB1, HSP90AA1, RELA, PRKAR1A, MYC | 0.00366914502124 | JUN, STAT5B, RXRA, CREBBP, MAPK3, RELA, HSPA1A, NCOR2, [NAME] | 0.00174134344484
Metabolism of mRNA | Reactome | 230 | RPL36, RPL6, [NAME], [NAME], RPS9, [NAME], [NAME], [NAME], RPL15, ANP32A, RPS3A, NCBP1, HSPB1, EXOSC4, RPS6, RPL22, RPS19, [NAME], [NAME], RPLP0 | 0.0197773978728 | AKT1, RPL13, [NAME], EDC4, RPL28, RPL10, [NAME], PRKCD, HSPA1A, RPS8, HNRNPD, FAU, [NAME], RPS14, [NAME], UPF1, RPS13, RPS17, RPL18, CASC3, [NAME], RPLP0 | 0.00424441189884
Metabolism of nitric oxide | Reactome | 20 | [NAME], HSP90AA1, [NAME], [NAME], CALM3, [NAME] | 0.000181951399867 | AKT1, [NAME], [NAME], DNM2, CALM2, CALM3 | 0.00294346916819
Metabolism of RNA | Reactome | 278 | [NAME], [NAME], [NAME], RPS9, [NAME], [NAME], [NAME], ANP32A, SNRPB, RPS3A, NCBP1, [NAME], RPL15, EXOSC4, RPS6, RPL6, RPL22, RPS19, [NAME], [NAME], RPLP0, CLNS1A | 0.0252403016159 | AKT1, RPL13, [NAME], EDC4, [NAME], RPL28, RPL10, PRKCD, HSPA1A, HNRNPD, FAU, [NAME], RPS14, [NAME], UPF1, RPS13, RPS17, RPL18, CASC3, [NAME], RPS8, RPLP0 | 0.00781940027808
MicroRNAs in cardiomyocyte hypertrophy | Wikipathways | 105 |  |  | PDPK1, ROCK2, IKBKB, MAPK3, STAT3, RAC1, RHOA, [NAME], DVL1, AKT1, [NAME] | 0.000801556972599
miRNA regulation of DNA Damage Response | Wikipathways | 100 |  |  | ABL1, CDK4, RPA2, CCND1, SFN, CDKN1A | 0.00920594382689
miRNAs involved in DDR | Wikipathways | 71 | CREB1, MYC, CDKN1A | 0.0147299995039
mRNA Capping | PID | 28 |  |  | POLR2A, POLR2E, POLR2C, GTF2F1, POLR2G | 0.0144868510133
mRNA processing | Wikipathways | 126 | YBX1, [NAME], HNRNPU, SRRM1, HNRNPA1, NCBP1, [NAME], SNRPB, HNRNPA2B1, HNRNPAB, HNRNPC, PRPF40A, HNRNPK | 0.0209161131546
mTOR signaling pathway | PID | 65 |  |  | AKT1, [NAME], RHEB, [NAME], HRAS, MAPK3, IKBKB, SREBF1, TSC2, SFN, YY1 | 0.000801556972599
multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation | PID | 13 |  |  | SHC1, HRAS, MAPK3, GRB2 | 0.00781940027808
Muscle contraction | Reactome | 52 | [NAME], CALM3, CALM2 | 0.00579278872412 | [NAME], [NAME], TLN1, VIM, PXN, MYL6, CALM3, VCL, TPM2 | 0.00101414215318
MyD88 cascade initiated on plasma membrane | Reactome | 76 |  |  | IRAK1, JUN, MAPK3, MYD88, FOS, RELA, IKBKB, RPS6KA2, TMEM189-UBE2V1 | 0.00781940027808
MyD88 dependent cascade initiated on endosome | Reactome | 79 |  |  | IRAK1, JUN, MAPK3, MYD88, FOS, IKBKB, RELA, RPS6KA2, TMEM189-UBE2V1 | 0.00977716988666
MyD88:[NAME] cascade initiated on plasma membrane | Reactome | 82 |  |  | IRAK1, JUN, FOS, MYD88, RELA, IKBKB, RPS6KA2, MAPK3, TMEM189-UBE2V1 | 0.00781940027808
Myogenesis | Reactome | 31 | CTNNB1, CDC42, BNIP2 | 0.0249198523019
Myometrial Relaxation and Contraction Pathways | Wikipathways | 155 | ACTB, CREB1, YWHAZ, PRKAR1A, JUN, ATF4, CREB3, CALM3, YWHAQ, [NAME], [NAME] | 0.000812096613293 | PRKCZ, ACTB, [NAME], PRKCD, ACTG1, SFN, JUN, FOS, ATF4, CREB3, CALM3, [NAME], [NAME] | 0.0144868510133
N-cadherin signaling events | PID | 39 | [NAME], [NAME], CTNNB1, CDC42, CALM3, RAC1, RHOA | 0.00342404695615 | FGFR1, [NAME], [NAME], CDC42, [NAME], JUP, CALM3, RAC1, RHOA, PTPN1 | 9.92409925423e-05
NCAM signaling for neurite out-growth | PID | 11 |  |  | FGFR1, SRC, FYN, GRB2 | 0.00243688506669
Nectin adhesion pathway | PID | 32 | CDH1, CTNNB1, CDC42, PTK2, RAC1, IQGAP1 | 0.00366914502124
Nef and signal transduction | PID | 8 |  |  | HCK, RAC1, FYN | 0.00977716988666
Nephrin/Neph1 signaling in the kidney podocyte | PID | 30 |  |  | AKT1, JUN, FYN, GRB2, PRKCZ, RAC1 | 0.000510480405482
nerve growth factor pathway (ngf) | PID | 18 | SHC1, JUN, CSNK2A1 | 0.0249198523019 | SHC1, FOS, HRAS, MAPK3, JUN, GRB2 | 0.000117832767738
Netrin-1 signaling | Reactome | 39 | SIAH2, PTK2, RAC1, EZR, CDC42 | 0.00325548104523 | SRC, FYN, RAC1, EZR, SIAH1, CDC42 | 0.00920594382689
Netrin-mediated signaling events | PID | 34 | RHOA, PTK2, RAC1, CDC42 | 0.0249198523019 | RHOA, SRC, MAPK3, FYN, RAC1, CDC42 | 0.00920594382689
Neural Crest Differentiation | Wikipathways | 101 | CTNNB1, CDH1, HDAC3, TFAP2A, MYC, ITGB1, HDAC1, HDAC2, CTBP2 | 5.61639900135e-05
Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | Wikipathways | 16 | CALM3, CREB1, [NAME], [NAME] | 0.0118684603594 | PDPK1, [NAME], [NAME], [NAME] | 0.00243688506669
Neurotrophic factor-mediated Trk receptor signaling | PID | 65 |  |  | SQSTM1, CCND1, HRAS, CRK, CDC42, ABL1, STAT3, GRB2, MCF2L, PRKCZ, SHC1, MAGED1, RHOA, RAC1, MAPK3 | 5.19246784058e-06
New Pathway | Wikipathways | 55 | HDAC1, EGFR, RHOA, JUN, PLAU, RAC1 | 0.00545242500279 | CLU, DVL1, AKT1, [NAME], LRP1, RHOA, JUN, RAC1 | 0.00294346916819
NF-kB is activated and signals survival | Reactome | 14 |  |  | SQSTM1, IRAK1, RELA, IKBKB | 0.0144868510133
nf-kb signaling pathway | PID | 21 |  |  | IRAK1, MYD88, RELA, FADD, IKBKB, TNFRSF1A | 0.00294346916819
nfat and hypertrophy of the heart | PID | 44 |  |  | AKT1, [NAME], CREBBP, HRAS, GRB2, SHC1, CALR | 0.00181177682958
NFkB and MAP kinases activation mediated by TLR4 signaling repertoire | Reactome | 69 |  |  | IRAK1, JUN, IKBKB, RELA, FOS, RPS6KA2, MAPK3 | 0.0196222321142
NGF | INOH | 21 |  |  | GRB2, SHC1, HRAS, PRKCD, MAPK3 | 0.00510197772482
NGF signalling via TRKA from the plasma membrane | Reactome | 136 | RHOA, TRIB3, CALM3, CREB1, [NAME], [NAME] | 0.000181951399867 | AKT1, HRAS, RALGDS, [NAME], CALM3, SHC1, CALM2, PRKCD, [NAME], SRC, TSC2, CRK, DNM2, GRB2, [NAME], RHOA, MAPK3, CDKN1A, STAT3, RPS6KA2 | 1.84928977906e-05
NOD pathway | Wikipathways | 39 | HSP90AA1, RELA, COPS6, RAC1 | 0.0249198523019
Noncanonical Wnt signaling pathway | PID | 34 | FLNA, CDC42, RAC1, RHOA, MAP3K7 | 0.0118684603594 | SETDB1, DVL1, CDC42, RAC1, RHOA, PRKCZ | 0.000510480405482
Nongenotropic Androgen signaling | PID | 32 |  |  | AKT1, GNAI2, SRC, HRAS, MAPK3, CDC42, FOS, RAC1 | 0.000243323451392
Nonsense Mediated Decay Enhanced by the Exon Junction Complex | Reactome | 159 | [NAME], [NAME], RPS3A, [NAME], RPL22, RPS19, RPS3, NCBP1, RPS7, [NAME], [NAME], RPL6, RPS6, [NAME], RPL15, RPLP0 | 0.0249198523019
Nonsense-Mediated Decay | Reactome | 159 | [NAME], [NAME], RPS3A, [NAME], RPL22, RPS19, RPS3, NCBP1, RPS7, [NAME], [NAME], RPL6, RPS6, [NAME], RPL15, RPLP0 | 0.0249198523019
Notch | NetPath | 58 |  |  | AKT1, SRC, NCOR2, MAPK3, RELA, STAT3, APH1A, YY1 | 0.0196632428826
Notch signaling pathway | PID | 53 | HDAC1, RAB11A, CDKN1A, APH1A, RBBP8, PSENEN, MYC, PSEN1 | 0.00149596524311
Notch Signaling Pathway | Wikipathways | 61 | PSENEN, PSEN1, HDAC2, HDAC1, MYC, CDKN1A, APH1A, HIF1A | 0.00149596524311
Notch-mediated HES/HEY network | PID | 48 | [NAME], RB1, RBBP8, HIF1A | 0.0178902884005 | CTBP1, CREBBP, KDR, NCOR2, CD4, [NAME], [NAME], YY1 | 0.00692569044098
NRIF signals cell death from the nucleus | Reactome | 17 | APH1A, PSENEN, PSEN1 | 0.0249198523019
nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells | PID | 8 |  |  | RARA, NCOR2, RXRA | 0.00977716988666
Opioid Signalling | Wikipathways | 13 | CALM3, PPP1CA, [NAME], CREB1, CALM2 | 0.000812096613293 | CALM3, PPP1CA, [NAME], [NAME] | 0.00243688506669
[NAME] | Wikipathways | 11 |  |  | MAPK3, IKBKB, RELA | 0.00977716988666
Osteopontin-mediated events | PID | 33 | JUN, CDC42, RELA, RAC1, RHOA, PLAU | 0.000831366847649 | JUN, ROCK2, SRC, MAPK3, CDC42, RELA, FOS, RAC1, RHOA, ILK | 4.69482351643e-05
p130Cas linkage to MAPK signaling for integrins | Reactome | 15 |  |  | SRC, VWF, FN1, TLN1, CRK | 0.000512005256097
p38 MAPK Signaling Pathway | Wikipathways | 34 | SHC1, MYC, CDC42, MAP3K7, [NAME], CREB1, RAC1 | 0.000237807324051 | SHC1, GRB2, CDC42, HRAS, [NAME], RAC1 | 0.00294346916819
p38 mapk signaling pathway | PID | 35 | [NAME], CREB1, RAC1, MYC, CDC42 | 0.00325548104523
p38 MAPK signaling pathway | PID | 29 | [NAME], [NAME], CALM3, MAP3K7, TXN, RAC1 | 0.000181951399867 | [NAME], [NAME], CALM3, RAC1 | 0.00781940027808
p38 signaling mediated by MAPKAP kinases | PID | 22 | YWHAQ, [NAME], YWHAZ, CREB1 | 0.0178902884005 | CDC25B, [NAME], [NAME], TSC2, SFN | 0.00207046669091
p53 pathway | PID | 59 |  |  | AKT1, CREBBP, ABL1, [NAME], TRIM28, [NAME], YY1 | 0.00524316513912
p53 signaling pathway | PID | 13 | RB1, PCNA, CDKN1A | 0.0249198523019
p73 transcription factor network | PID | 79 | FAS, GNB2L1, IL1RAP, RELA, MYC, RB1, CDKN1A | 0.0134626380933 | GNB2L1, RELA, ABL1, HSF1, KAT5, SFN, FASN, CDKN1A | 0.0196632428826
p75 NTR receptor-mediated signalling | Reactome | 88 | HDAC1, HDAC3, RAC1, APH1A, RHOA, RELA, AATF, PSENEN, HDAC2, PSEN1 | 0.000376258877154 | IRAK1, MCF2L, MAGED1, MYD88, RAC1, IKBKB, APH1A, SQSTM1, RHOA, ARHGDIA, RELA, AATF | 0.000182265270316
p75(NTR)-mediated signaling | PID | 71 |  |  | SQSTM1, IRAK1, AKT1, ARHGDIA, MYD88, IKBKB, PRKCZ, RAC1, APH1A, SHC1, MAGED1, RHOA | 1.93342810337e-05
[NAME] negatively regulates cell cycle via SC1 | Reactome | 6 | HDAC2, HDAC1, HDAC3 | 0.0147299995039
[NAME] recruits signalling complexes | Reactome | 9 |  |  | SQSTM1, IRAK1, MYD88, IKBKB | 0.00243688506669
[NAME] signals via NF-kB | Reactome | 17 |  |  | SQSTM1, IRAK1, MYD88, RELA, IKBKB | 0.00510197772482
PAR1-mediated thrombin signaling events | PID | 44 |  |  | GNA11, DNM2, ROCK2, ARHGDIA, RHOA, GNAI2, PRKCD | 0.0144868510133
Pausing and recovery of elongation | PID | 32 |  |  | COBRA1, POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, POLR2G | 0.0105607939073
Pausing and recovery of HIV-1 elongation | PID | 32 |  |  | COBRA1, POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, POLR2G | 0.0105607939073
Pausing and recovery of Tat-mediated HIV-1 elongation | PID | 31 |  |  | COBRA1, POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, POLR2G | 0.0105607939073
PDGF | INOH | 47 |  |  | AKT1, JUN, [NAME], STAT5B, HRAS, CDC42, GRB2, SHC1, CRK, MAPK3 | 4.69482351643e-05
pdgf signaling pathway | PID | 27 |  |  | JUN, HRAS, MAPK3, GRB2, SHC1, FOS, STAT3 | 0.000117832767738
PDGFR-alpha signaling pathway | PID | 22 | JUN, SHC1, CSNK2A1, CAV1 | 0.0118684603594 | JUN, GRB2, FOS, SHC1, CRK, CAV1 | 0.000117832767738
PDGFR-beta signaling pathway | PID | 130 | JUN, SHC1, YWHAQ, RAC1, [NAME], PTEN, SLC9A3R1, IQGAP1, RHOA, YWHAZ, MYC | 0.00991956730117 | JUN, RAB4A, HRAS, FYN, SHC1, GRB2, PTPN1, [NAME], LRP1, [NAME], HCK, SRC, FOS, RAC1, CRK, SFN, DNM2, ABL1, JUND, BAIAP2, STAT5B, TAGLN, RHOA, ARHGDIA, MAPK3, STAT3 | 8.560626556e-10
Peptide chain elongation | PID | 141 | [NAME], [NAME], RPS3A, RPL22, RPS19, RPS3, [NAME], [NAME], [NAME], RPL6, RPS6, EEF1A1, [NAME], RPL15, RPLP0 | 0.0249198523019
phosphoinositides and their downstream targets | PID | 21 |  |  | AKT1, RAC1, PFKL, [NAME], PRKCZ, ARF1 | 0.000510480405482
Phospholipase C-mediated cascade | Reactome | 56 | CALM2, PRKAR1A, CALM3, [NAME], CREB1 | 0.000812096613293
phospholipids as signalling intermediaries | PID | 33 |  |  | AKT1, [NAME], SRC, HRAS, MAPK3, GRB2, RAC1, SHC1 | 0.00101414215318
phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway | PID | 14 |  |  | SHC1, HRAS, MAPK3, GRB2 | 0.0144868510133
Physiological and Pathological Hypertrophy of the Heart | Wikipathways | 24 | RHOA, JUN, [NAME], RAC1 | 0.00330436188925 | RHOA, JUN, STAT3, FOS, [NAME], RAC1 | 0.0014466921551
PI-3K cascade | Reactome | 58 | TRIB3, CDKN1A, CREB1, PTEN | 0.0118684603594 | FGFR1, [NAME], AKT1, GRB2, CDKN1A, TSC2 | 0.0129798766226
PI3K Cascade | Reactome | 74 |  |  | FGFR1, RHEB, [NAME], GRB2, TSC2, PRKAB1 | 0.0179633317051
PI3K events in ERBB2 signaling | Reactome | 44 | TRIB3, EGFR, CDKN1A, CREB1, PTEN | 0.00545242500279 | AKT1, [NAME], EGFR, GRB2, ERBB2, CDKN1A, TSC2 | 0.00524316513912
PI3K events in ERBB4 signaling | Reactome | 38 | TRIB3, CDKN1A, CREB1, PTEN | 0.0178902884005
PI3K/AKT activation | Reactome | 37 | TRIB3, RHOA, CDKN1A, CREB1, PTEN | 0.00545242500279
PIP3 activates AKT signaling | Reactome | 28 | TRIB3, CDKN1A, CREB1, PTEN | 0.00675203838849
PKA activation | PID | 3 | CALM2, CALM3, [NAME] | 0.00579278872412 | CALM2, CALM3, [NAME] | 0.00977716988666
Plasma membrane estrogen receptor signaling | PID | 42 |  |  | GNA11, AKT1, ROCK2, SRC, HRAS, MSN, GRB2, SHC1, RHOA, GNAI2 | 0.000336634411438
Platelet activation, signaling and aggregation | Reactome | 215 | FLNA, CALM3, SHC1, GNA15, [NAME], CD9, RAC1, FN1, CDC42, CALM2, VEGFA, RHOA, PTK2, YWHAZ | 0.00300207804492 | AKT1, VWF, VCL, GNA11, FYN, CALM3, SHC1, PTPN1, PRKCD, LAMP2, PECAM1, GNAI2, [NAME], CD9, SRC, PRKCZ, RAC1, CRK, FN1, CDC42, CALM2, GRB2, [NAME], TLN1, RHOA, MAPK3, A2M, CLU | 6.71993328095e-06
Platelet Aggregation (Plug Formation) | Reactome | 37 | PTK2, SHC1, FN1 | 0.0249198523019 | AKT1, [NAME], TLN1, VWF, SRC, GRB2, SHC1, PTPN1, CRK, FN1 | 4.19911282939e-07
Platelet degranulation | Reactome | 85 |  |  | VWF, [NAME], [NAME], TLN1, CD9, CALM3, A2M, CLU, VCL, LAMP2, FN1, PECAM1 | 0.0156166548851
PLC beta mediated events | Reactome | 45 | [NAME], [NAME], PRKAR1A, CALM3, CREB1 | 0.00791876054924
PLC-gamma1 signalling | Reactome | 35 | [NAME], [NAME], PRKAR1A, CALM3, CREB1 | 0.000812096613293
PLCG1 events in ERBB2 signaling | Reactome | 36 | [NAME], [NAME], [NAME], PRKAR1A, CALM3, CREB1 | 0.000181951399867 | [NAME], [NAME], [NAME], ERBB2, CALM3, PRKCD | 0.00554461619866
PLK1 signaling events | PID | 44 |  |  | CDC25B, ROCK2, NUDC, RHOA | 0.0144868510133
Post NMDA receptor activation events | Reactome | 35 | [NAME], [NAME], CALM3, CREB1 | 0.0178902884005 | PDPK1, [NAME], HRAS, [NAME], CALM3, RPS6KA2, RRAS | 0.000361350243226
Posttranslational regulation of adherens junction stability and dissassembly | PID | 58 |  |  | FGFR1, CDC42, CREBBP, ABL1, HGS, HRAS, FYN, EGFR, JUP, RAC1, PTPN1, DNM2, SRC | 6.55346776519e-05
[NAME] action in Notch and Wnt signaling | PID | 46 | JUN, HDAC1, CTNNB1, CSNK2A1, APH1A, MAP3K7, PSENEN, MYC, PSEN1 | 0.000181951399867 | CTBP1, JUN, MAPK3, CCND1, DVL1, CREBBP, [NAME], APH1A, FOS, [NAME] | 0.000336634411438
Processing of Capped Intron-Containing Pre-mRNA | PID | 38 | SRRM1, [NAME], HNRNPA2B1, [NAME], HNRNPA1, NCBP1, [NAME], HNRNPU, HNRNPK, DHX9 | 0.00190714522291 | HNRNPD, POLR2A, POLR2E, HNRNPM, POLR2C, GTF2F1, POLR2G | 0.0105607939073
[NAME] | Wikipathways | 75 | RAC1, PXN, YWHAZ, PTK2, MYC, JUN, ITGB1, FLNA, SHC1, RPS6, RELA | 9.35638982272e-05 | RAC1, GRB2, PXN, PTPN1, AKT1, HRAS, JUN, SRC, STAT3, MAPK3, STAT5B, SHC1, RPS6KA2, FOS, RELA, ERBB2, FYN | 8.31515039956e-06
Prolonged ERK activation events | Reactome | 19 |  |  | [NAME], HRAS, MAPK3, CRK | 0.00781940027808
pten dependent cell cycle arrest and apoptosis | PID | 15 | PTEN, PTK2, SHC1, ITGB1 | 0.00106705078009 | ILK, GRB2, SHC1, AKT1 | 0.00781940027808
RANKL-RANK Signaling Pathway | Wikipathways | 55 | PTK2, CDC42, MAP3K7, JUN, RELA, RAC1 | 0.00137034443883 | SRC, IKBKB, AKT1, CDC42, JUN, RELA, MAPK3, SQSTM1, FOS, RAC1 | 0.000182265270316
[NAME] activation uopn Ca2+ infux through NMDA receptor | Reactome | 19 | [NAME], [NAME], CALM3 | 0.0147299995039 | HRAS, [NAME], [NAME], CALM3 | 0.00243688506669
[NAME] signaling in the CD4+ TCR pathway | PID | 14 |  |  | MAPK3, HRAS, FOS | 0.00977716988666
ras signaling pathway | PID | 21 | RHOA, CDC42, BCL2L1, RAC1 | 0.0118684603594 | RHOA, HRAS, RALGDS, [NAME], CDC42, BCL2L1, RAC1, AKT1 | 8.31515039956e-06
ras-independent pathway in nk cell-mediated cytotoxicity | PID | 22 |  |  | HLA-A, MAPK3, RAC1, B2M | 0.0144868510133
Regulated proteolysis of [NAME] | Reactome | 11 | APH1A, RELA, PSEN1, PSENEN | 0.00330436188925
Regulation of [NAME] | Wikipathways | 148 | PTK2, PXN, CDC42, EGFR, EZR, RHOA, RAC1, ACTB, IQGAP1, FN1 | 0.017698982631 | ROCK2, MSN, BAIAP2, PXN, CDC42, EGFR, MAPK3, EZR, CRK, FGFR1, RHOA, RAC1, ACTB, VCL, RRAS2, ACTG1, FN1, RRAS | 5.16849727908e-05
Regulation of Androgen receptor activity | PID | 51 | HDAC1, HSP90AA1, [NAME], GNB2L1 | 0.0249198523019 | CEBPA, RXRA, CREBBP, SRC, KAT5, [NAME], GNB2L1 | 0.00789351157551
Regulation of cytoplasmic and nuclear SMAD2/3 signaling | PID | 20 | UBE2I, [NAME], [NAME], KPNA2, KPNB1, CALM3 | 0.000831366847649 | UBE2I, CALM2, MAPK3, [NAME], CALM3 | 0.00954441103043
Regulation of [NAME] | Wikipathways | 44 |  |  | ABL1, SRC, DVL1, AKT1, CDC42, STAT3, RAC1 | 0.00307415709423
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements | Reactome | 40 |  |  | AKT1, HSPA1A, [NAME], [NAME], PRKCD, HNRNPD, [NAME] | 0.0196222321142
Regulation of nuclear beta catenin signaling and target gene transcription | PID | 81 | CTNNB1, CDH1, YWHAQ, YWHAZ, JUN, HDAC1, HDAC2, MYC, CDKN2A | 0.00137034443883 | CTBP1, CCND1, SMARCA4, YWHAB, TERT, JUN, [NAME], SFN, TCF7L2 | 0.00174134344484
Regulation of nuclear SMAD2/3 signaling | PID | 78 | CREB1, HDAC1, CDKN1A, JUN, HDAC2, MYC | 0.0171663609324 | CTBP1, CREBBP, VDR, AKT1, FOS, CDKN1A, JUN, CDK4, CEBPB | 0.012313349942
Regulation of p38-alpha and p38-beta | PID | 32 |  |  | HCK, FYN, SRC, RAC1, CDC42 | 0.00207046669091
Regulation of Ras family activation | PID | 33 |  |  | CALM2, HRAS, [NAME], GRB2, PRKCZ, CALM3, RRAS | 0.000361350243226
Regulation of retinoblastoma protein | PID | 66 | JUN, [NAME], RB1, CDKN1A, AATF, CDKN2A, HDAC3 | 0.00154345737728 | CTBP1, CEBPA, JUN, CREBBP, ABL1, SMARCA4, CDKN1A, CDK4, AATF, CCND1, CEBPB | 6.15674897347e-05
Regulation of Rheb GTPase activity by AMPK | Reactome | 10 |  |  | RHEB, TSC2, PRKAB1 | 0.00977716988666
Regulation of signaling by CBL | Reactome | 18 |  |  | FYN, GRB2, CRK, HCK | 0.00243688506669
Regulation of Telomerase | PID | 73 | HDAC1, NCL, HNRNPC, HSP90AA1, EGFR, HDAC2, MYC, JUN | 0.00396549110158 | AKT1, TERT, [NAME], [NAME], XRCC6, CCND1, FOS, NR2F2, JUN, MAPK3 | 0.00053353335503
Regulation of toll-like receptor signaling pathway | Wikipathways | 147 |  |  | IRAK1, IKBKB, MAPK3, SQSTM1, RAC1, [NAME], [NAME], TOLLIP, FOS, MYD88, AKT1, RELA | 0.00626326027798
regulation of transcriptional activity by pml | PID | 10 | UBE2I, [NAME], RB1 | 0.00579278872412
repression of pain sensation by the transcriptional regulator dream | PID | 15 | JUN, PRKAR1A, CREB1 | 0.00579278872412 | MAPK3, JUN, FOS, POLR2A | 0.00781940027808
Response to elevated platelet cytosolic Ca2+ | Reactome | 90 |  |  | VWF, CALM2, CALM3, LAMP2, PECAM1, [NAME], CD9, FN1, VCL, TLN1, A2M, CLU | 0.0189037698515
Retinoic acid receptors-mediated signaling | PID | 30 |  |  | AKT1, RARA, RXRA, CREBBP, VDR, MAPK3, NCOR2 | 0.000117832767738
RhoA signaling pathway | PID | 47 | RHOA, JUN, EZR, PTEN, ITGB1, CDC42 | 0.00761886998935 | RHOA, JUN, TLN1, FOS, PRKCZ, ROCK2, EZR, VCL, MSN, CDC42 | 0.000182265270316
RNA [NAME] CTD phosphorylation and interaction with CE | PID | 26 |  |  | POLR2A, POLR2E, POLR2C, GTF2F1, POLR2G | 0.0144868510133
RNA Polymerase II HIV-1 Promoter [NAME] | PID | 40 |  |  | POLR2A, TAF11, POLR2E, POLR2C, GTF2F1, POLR2G | 0.0179633317051
RNA Polymerase II Pre-transcription Events | PID | 60 |  |  | POLR2A, TAF11, POLR2E, [NAME], POLR2C, GTF2F1, COBRA1, POLR2G | 0.0119214265967
RNA Polymerase II Promoter Escape | PID | 40 |  |  | POLR2A, TAF11, POLR2E, POLR2C, GTF2F1, POLR2G | 0.0179633317051
RNA Polymerase II Transcription | PID | 60 |  |  | POLR2A, TAF11, POLR2E, [NAME], POLR2C, GTF2F1, COBRA1, POLR2G | 0.0119214265967
RNA Polymerase II Transcription Elongation | PID | 44 |  |  | POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, COBRA1, POLR2G | 0.0105607939073
RNA Polymerase II Transcription Initiation | PID | 40 |  |  | POLR2A, TAF11, POLR2E, POLR2C, GTF2F1, POLR2G | 0.0179633317051
RNA Polymerase II Transcription Initiation And Promoter Clearance | PID | 40 |  |  | POLR2A, TAF11, POLR2E, POLR2C, GTF2F1, POLR2G | 0.0179633317051
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | PID | 40 |  |  | POLR2A, TAF11, POLR2E, POLR2C, GTF2F1, POLR2G | 0.0179633317051
Role of Calcineurin-dependent NFAT signaling in lymphocytes | PID | 57 | [NAME], [NAME], CSNK2A1, BCL2L1, CALM3, YWHAZ, YWHAQ, KPNA2, CALM2 | 0.000376258877154 | [NAME], CREBBP, MAPK3, BCL2L1, CALM3, PRKCZ, [NAME], SFN, PRKCD, CALM2 | 0.000336634411438
role of egf receptor transactivation by gpcrs in cardiac hypertrophy | PID | 33 | JUN, RHOA, RELA, EGFR, SHC1, MYC | 0.00238876218746 | EDNRA, GNA11, JUN, RHOA, HRAS, MAPK3, RELA, EGFR, IKBKB, SHC1, GRB2, FOS, EDNRB | 3.10690123638e-06
role of erbb2 in signal transduction and oncology | PID | 29 |  |  | AKT1, [NAME], HRAS, MAPK3, EGFR, GRB2, ERBB2, SHC1, STAT3 | 8.41637705443e-06
role of erk5 in neuronal survival pathway | PID | 28 |  |  | AKT1, [NAME], HRAS, MAPK3, GRB2, SHC1 | 0.0014466921551
role of mal in rho-mediated activation of srf | PID | 21 |  |  | RHOA, MAPK3, CDC42, RAC1, HRAS | 0.00207046669091
role of nicotinic acetylcholine receptors in the regulation of apoptosis | PID | 17 |  |  | SRC, TERT, [NAME], AKT1 | 0.0144868510133
role of ran in mitotic spindle regulation | PID | 11 | KPNA2, RCC1, KPNB1 | 0.0249198523019
roles of &#xdf; arrestin dependent recruitment of src kinases in gpcr signaling | PID | 36 |  |  | EDNRA, HCK, SRC, HRAS, MAPK3, EDNRB | 0.0179633317051
[NAME] and RAR heterodimerization with other nuclear receptor | PID | 26 |  |  | RARA, RXRA, VDR, NCOR2, SREBF1 | 0.0144868510133
S Phase | Reactome | 67 |  |  | CCND1, CDC25B, RPA2, CDK4, CDKN1A | 0.00510197772482
S1P2 pathway | PID | 26 | JUN, RHOA, RAC1, GNA15 | 0.0249198523019 | GNA11, JUN, CDH5, RHOA, MAPK3, FOS, RAC1, GNAI2 | 9.92409925423e-05
S1P3 pathway | PID | 26 | RHOA, RAC1, GNA15, VEGFA | 0.0178902884005 | GNA11, GNAI2, AKT1, RHOA, SRC, MAPK3, RAC1 | 0.00524316513912
S1P4 pathway | PID | 15 |  |  | RHOA, MAPK3, CDC42, GNAI2 | 0.00243688506669
[NAME] PAK dependent Axon repulsion | Reactome | 15 | HSP90AA1, RAC1, HSP90AB1 | 0.0249198523019
[NAME] repulsion signaling by inhibiting Integrin adhesion | PID | 10 |  |  | RRAS, FYN, TLN1, RAC1 | 0.00781940027808
Sema4D in semaphorin signaling | Reactome | 31 |  |  | ROCK2, ERBB2, [NAME], RAC1, RHOA, MYH9, RRAS, CDC42 | 0.00692569044098
Sema4D induced cell migration and growth-cone collapse | Reactome | 26 |  |  | ROCK2, ERBB2, [NAME], RAC1, RHOA, MYH9, CDC42 | 0.0144868510133
Sema4D mediated inhibition of cell attachment and migration | PID | 8 |  |  | RHOA, RRAS, RAC1 | 0.00977716988666
Semaphorin interactions | Reactome | 68 | CDC42, HSP90AA1, RAC1, RHOA, HSP90AB1, ITGB1 | 0.0219151018017 | CDC42, TLN1, ROCK2, FYN, ERBB2, [NAME], RAC1, [NAME], MYH9, RHOA | 0.00784195330948
Senescence and Autophagy | Wikipathways | 105 | IGFBP7, MAP1LC3B, PLAU, JUN, CDKN1A, CDKN2A, PCNA, PTEN, RB1, FN1 | 0.00791876054924 | LAMP2, SRC, SQSTM1, MAP1LC3B, HRAS, JUN, CDKN1A, CDC25B, CEBPB, FN1 | 0.0180564031563
Serotonin HTR1 Group and FOS Pathway | Wikipathways | 33 |  |  | PDPK1, GNAI2, RHOA, MAPK3, FOS | 0.00510197772482
Shc events in EGFR signaling | PID | 5 |  |  | EGFR, GRB2, SHC1 | 0.00977716988666
SHC-mediated cascade | Reactome | 29 |  |  | FGFR1, HRAS, GRB2, SHC1 | 0.00781940027808
SHC-mediated signalling | Reactome | 15 |  |  | SHC1, HRAS, MAPK3, GRB2, [NAME] | 0.00207046669091
SHC-related events | Reactome | 18 |  |  | SHC1, HRAS, MAPK3, GRB2, [NAME] | 0.00207046669091
SHC1 events in EGFR signaling | Reactome | 15 |  |  | EGFR, SHC1, HRAS, MAPK3, GRB2, [NAME] | 0.000510480405482
SHC1 events in ERBB2 signaling | Reactome | 25 |  |  | HRAS, MAPK3, EGFR, GRB2, ERBB2, SHC1, YWHAB | 0.000361350243226
SHC1 events in ERBB4 signaling | Reactome | 21 |  |  | SHC1, HRAS, MAPK3, GRB2, [NAME] | 0.00510197772482
Signal attenuation | PID | 9 |  |  | SHC1, MAPK3, GRB2, CRK | 0.00781940027808
Signal Transduction | Reactome | 1598 | EGFR, CDKN1A, ITGB1, TRIB3, GNA15, CALM2, PSEN1, HDAC3, PPP1CA, RAC1, PPP2R1A, ITGA3, PTK2, PSENEN, CALM3, [NAME], APH1A, CDH1, AATF, FN1, HDAC1, PTEN, RPS6, HSP90AA1, CDC42, SHC1, CTNNB1, PXN, VEGFA, RHOA, RELA, CREB1, PRKAR1A, ANXA1, HIF1A, HDAC2, STUB1 | 0.000116954962056 | AKT1, DNM2, ITGB2, STAT6, GNA11, FYN, MYD88, EGFR, MCF2L, CREBBP, CDKN1A, AXIN1, SMAD1, ERBB2, COL4A2, CALM2, PECAM1, SRC, GRB2, TLN1, MAPK3, HRAS, DTX2, PPP1CA, VWF, RALGDS, RAC1, EDNRB, TRIP10, PRKAB1, IRAK1, CALM3, [NAME], APH1A, GNAI2, AATF, FN1, A2M, TLE1, CRK, STAT5B, NCOR2, STAT3, CDC42, [NAME], KDR, SHC1, RPS6KA2, MAGED1, ITGAM, SQSTM1, PXN, IKBKB, RHOA, RELA, PTPN1, PRKCD, RHEB, ROCK2, FGFR1, TSC2, EDNRA, HGS, STUB1, [NAME], ARHGDIA | 8.7474200897e-07
Signal transduction by L1 | PID | 23 |  |  | FGFR1, MAPK3, EGFR, RAC1, CSNK2B | 0.0144868510133
signal transduction through il1r | PID | 37 | JUN, TOLLIP, RELA, MAP3K7, IL1RAP | 0.00791876054924 | IRAK1, JUN, TOLLIP, MYD88, RELA, FOS, IKBKB | 0.00307415709423
Signaling by constitutively active EGFR | Reactome | 20 |  |  | SHC1, HRAS, EGFR, GRB2 | 0.0144868510133
Signaling by EGFR | Reactome | 114 | TRIB3, CALM2, CDC42, EGFR, PRKAR1A, CALM3, SHC1, CREB1, [NAME], PTEN, PXN, CDKN1A | 0.000237807324051 | AKT1, [NAME], HRAS, CDC42, EGFR, [NAME], CALM3, SHC1, PRKCD, [NAME], SRC, TSC2, HGS, GRB2, [NAME], [NAME], PXN, CDKN1A | 1.76991154119e-05
Signaling by EGFR in Cancer | Reactome | 116 | TRIB3, CDC42, EGFR, PRKAR1A, CALM3, SHC1, CREB1, [NAME], PTEN, [NAME], HSP90AA1, PXN, CDKN1A | 8.66330209263e-05 | AKT1, HRAS, CDC42, EGFR, [NAME], CALM3, SHC1, PRKCD, [NAME], SRC, TSC2, CALM2, HGS, GRB2, [NAME], [NAME], PXN, CDKN1A | 2.53062512282e-05
Signaling by ERBB2 | Reactome | 105 | TRIB3, [NAME], EGFR, PRKAR1A, CALM3, SHC1, CREB1, [NAME], PTEN, STUB1, HSP90AA1, CDKN1A | 4.90968288472e-05 | CALM2, AKT1, HRAS, FYN, EGFR, [NAME], CALM3, SHC1, PRKCD, [NAME], SRC, ERBB2, TSC2, GRB2, STUB1, [NAME], MAPK3, CDKN1A | 1.92377952317e-06
Signaling by ERBB4 | Reactome | 90 | TRIB3, EGFR, CREB1, SHC1, PTEN, APH1A, CDKN1A, PSENEN, PSEN1 | 0.00325548104523 | AKT1, HRAS, EGFR, SHC1, [NAME], TSC2, GRB2, APH1A, [NAME], STAT5B, MAPK3, CDKN1A | 0.000111904774638
Signaling by FGFR | Reactome | 117 | TRIB3, CALM2, CALM3, SHC1, CREB1, [NAME], PRKAR1A, [NAME], PTEN, CDKN1A | 0.000376258877154 | CALM2, AKT1, HRAS, [NAME], CALM3, SHC1, PRKCD, FGFR1, [NAME], SRC, TSC2, GRB2, [NAME], MAPK3, CDKN1A | 5.74990610931e-05
Signaling by GPCR | Reactome | 987 | RHOA, PPP1CA, CDC42, CREB1, PRKAR1A, RAC1, PPP2R1A, ANXA1, CALM3, GNA15, [NAME], [NAME] | 0.00467997181845
Signaling by Insulin receptor | Reactome | 113 |  |  | HRAS, SHC1, [NAME], RHEB, TSC2, FGFR1, CRK, GRB2, PRKAB1, [NAME], MAPK3 | 0.00343296835103
Signaling by Interleukins | Reactome | 114 |  |  | IRAK1, HRAS, FYN, SHC1, [NAME], MYD88, CRK, TMEM189-UBE2V1, STAT3, GRB2, IKBKB, SQSTM1, STAT5B, MAPK3, RELA, TOLLIP, HCK | 5.02233026308e-07
Signaling by NOTCH | Reactome | 90 | HDAC1, HDAC3, APH1A, HIF1A, PSENEN, HDAC2, PSEN1 | 0.0163620818244
Signaling by NOTCH1 | Reactome | 69 | HDAC1, APH1A, HIF1A, PSENEN, HDAC2, PSEN1, HDAC3 | 0.0134626380933
Signaling by NOTCH2 | Reactome | 12 | APH1A, PSENEN, PSEN1 | 0.0249198523019
Signaling by NOTCH3 | Reactome | 12 | APH1A, PSENEN, PSEN1 | 0.0249198523019
Signaling by NOTCH4 | Reactome | 12 | APH1A, PSENEN, PSEN1 | 0.0249198523019
Signaling by PDGF | Reactome | 125 | TRIB3, CALM2, PRKAR1A, CALM3, CREB1, PTEN, [NAME], CDKN1A | 0.0123519735946 | AKT1, [NAME], HRAS, [NAME], CALM3, GRB2, PRKCD, SRC, TSC2, CRK, COL4A2, [NAME], STAT6, [NAME], STAT5B, MAPK3, CDKN1A, STAT3 | 7.25938895943e-05
Signaling by SCF-KIT | Reactome | 79 | TRIB3, RAC1, CDKN1A, CREB1, PTEN | 0.0258973656068 | [NAME], AKT1, [NAME], [NAME], HRAS, FYN, STAT3, RAC1, CDKN1A, SRC, TSC2, STAT5B, GRB2 | 0.000165631779156
Signaling by the B Cell Receptor (BCR) | Reactome | 103 | TRIB3, CALM2, CALM3, SHC1, CREB1, [NAME], PTEN, MAP3K7, RELA, CDKN1A | 0.000133398057981 | AKT1, [NAME], HRAS, CALM3, SHC1, [NAME], TSC2, GRB2, IKBKB, [NAME], RELA, CDKN1A | 0.000298134142131
Signaling events mediated by focal adhesion kinase | PID | 62 |  |  | RAC1, JUN, CCND1, TLN1, ROCK2, SRC, CRK, FYN, PXN, RHOA, GRB2, VCL, RRAS | 1.20194655566e-05
Signaling events mediated by HDAC Class I | PID | 57 | UBE2I, HDAC1, [NAME], RELA, CHD4, HDAC2, HDAC3 | 0.00342404695615 | UBE2I, TNFRSF1A, CREBBP, NCOR2, RELA, GATA2, STAT3, CHD3, YY1 | 0.00553811565282
Signaling events mediated by HDAC Class II | PID | 39 | UBE2I, SUMO1, HSP90AA1, HDAC3 | 0.0249198523019 | UBE2I, BCL6, NCOR2, GATA2, YWHAB | 0.00954441103043
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | PID | 84 | JUN, RAC1, SHC1, KPNB1, CDC42, PTK2, PXN, RHOA, CDH1, CTNNB1 | 0.00110701298823 | PTPN1, JUN, SRC, RAC1, SHC1, AKT1, MAPK3, HGS, HRAS, CRK, CDC42, PXN, PRKCZ, RHOA, GRB2, [NAME] | 3.02217802533e-06
Signaling events mediated by PRL | PID | 24 |  |  | RHOA, SRC, MAPK3, RAC1, CDKN1A | 0.00954441103043
Signaling events mediated by PTP1B | PID | 53 | EGFR, [NAME], SHC1, RHOA, TXN, [NAME] | 0.00137034443883 | STAT3, AKT1, EGFR, HCK, SRC, FYN, GRB2, SHC1, RHOA, PTPN1, CRK, STAT5B, [NAME], CAPN1 | 8.31515039956e-06
Signaling events mediated by Stem cell factor receptor (c-Kit) | PID | 53 |  |  | AKT1, [NAME], CREBBP, HRAS, MAPK3, GRB2, SHC1, STAT3 | 0.00476294592179
Signaling events mediated by TCPTP | PID | 41 | KPNB1, KPNA2, EGFR, VEGFA, SHC1, ITGB1 | 0.000831366847649 | KDR, CREBBP, SRC, EGFR, GRB2, SHC1, PTPN1, STAT3, STAT5B, STAT6 | 4.69482351643e-05
Signaling events mediated by VEGFR1 and VEGFR2 | PID | 72 | CALM2, HSP90AA1, HSP90AB1, PTK2, PXN, CALM3, RHOA, CDC42, IQGAP1, CAV1, VEGFA, CTNNB1, [NAME] | 4.70205273698e-06 | KDR, [NAME], DNM2, [NAME], AKT1, GRB2, MAPK3, HGS, FYN, PXN, CALM3, ARF1, SRC, RHOA, CDC42, VCL, CDH5, [NAME], [NAME], [NAME] | 3.60555633563e-08
Signaling events regulated by Ret tyrosine kinase | PID | 40 | JUN, RHOA, PTK2, PXN, RAC1, SHC1, CREB1 | 0.00106705078009 | JUN, RHOA, SRC, HRAS, MAPK3, PXN, RAC1, SHC1, GRB2, CRK | 2.06042634617e-05
Signaling of Hepatocyte Growth Factor Receptor | Wikipathways | 33 | PTK2, PTEN, PXN, JUN, ITGB1 | 0.0163620818244 | GRB2, PXN, CRK, HRAS, FOS, JUN, SRC, MAPK3, STAT3 | 8.41637705443e-06
Signalling by NGF | Reactome | 223 | TRIB3, HDAC1, [NAME], PRKAR1A, CALM3, SHC1, CREB1, HDAC3, [NAME], RAC1, [NAME], PTEN, APH1A, RHOA, AATF, RELA, CDKN1A, PSENEN, HDAC2, PSEN1 | 2.32563601158e-05 | AKT1, IRAK1, [NAME], HRAS, RALGDS, [NAME], CALM3, SHC1, MAGED1, PRKCD, [NAME], SRC, MYD88, ARHGDIA, RAC1, TSC2, CRK, DNM2, STAT3, GRB2, IKBKB, APH1A, MCF2L, SQSTM1, [NAME], RHOA, AATF, MAPK3, RELA, CDKN1A, RPS6KA2 | 3.60555633563e-08
Signalling to ERKs | Reactome | 34 |  |  | SRC, HRAS, RALGDS, MAPK3, GRB2, SHC1, CRK, YWHAB | 9.92409925423e-05
Signalling to RAS | Reactome | 25 |  |  | SRC, HRAS, RALGDS, MAPK3, GRB2, SHC1, YWHAB | 0.000361350243226
Smooth Muscle Contraction | Reactome | 24 | [NAME], [NAME], TPM4, PXN, CALM3 | 0.00791876054924 | [NAME], [NAME], TLN1, PXN, MYL6, CALM3, VCL, TPM2 | 0.00294346916819
SOS-mediated signalling | Reactome | 14 |  |  | HRAS, MAPK3, GRB2, [NAME] | 0.0144868510133
sprouty regulation of tyrosine kinase signals | PID | 20 |  |  | GRB2, EGFR, SHC1, SRC, MAPK3, HRAS | 0.00294346916819
sumoylation as a mechanism to modulate ctbp-dependent gene responses | PID | 8 | UBA1, [NAME], CDH1 | 0.0249198523019
Sumoylation by RanBP2 regulates transcriptional repression | PID | 15 | UBE2I, [NAME], HDAC1 | 0.0147299995039
Syndecan-2-mediated signaling events | PID | 43 | RHOA, EZR, GNB2L1, FN1, ITGB1 | 0.0219198853134 | FGFR1, RHOA, SRC, HRAS, MAPK3, EZR, GNB2L1, PRKCD, FN1 | 0.00101414215318
Syndecan-3-mediated signaling events | PID | 28 | EGFR, APH1A, PSENEN, PSEN1 | 0.00675203838849 | FGFR1, SRC, FYN, EGFR, APH1A | 0.00510197772482
Syndecan-4-mediated signaling events | PID | 32 | PTK2, RAC1, RHOA, FN1, ITGB1 | 0.0219198853134 | FGFR1, RAC1, RHOA, DNM2, PRKCD, FN1, SDC4 | 0.0144868510133
Synthesis of DNA | Reactome | 53 | [NAME], [NAME], PCNA, CDKN1A | 0.0249198523019
t cell receptor signaling pathway | PID | 55 |  |  | JUN, RELA, HRAS, MAPK3, FYN, GRB2, FOS, SHC1, CD4, RAC1 | 4.69482351643e-05
Tat-mediated elongation of the HIV-1 transcript | PID | 41 |  |  | COBRA1, POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, POLR2G | 0.0105607939073
Tat-mediated HIV-1 elongation arrest and recovery | PID | 31 |  |  | COBRA1, POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, POLR2G | 0.0105607939073
Tat-mediated HIV-1 elongation arrest and recovery | Reactome | 32 |  |  | COBRA1, POLR2A, POLR2E, [NAME], POLR2C, GTF2F1, POLR2G | 0.0144868510133
TCR | NetPath | 248 | NCL, CALM2, CALM3, SHC1, DDX3X, CREB1, HSP90AB1, YWHAQ, TUBB, EPRS, [NAME], ANXA2, FLNB, CTNNB1, RELA, PTK2, PXN, YWHAZ | 0.000301177639376 | AKT1, [NAME], [NAME], CALM3, SHC1, CD4, PRKCD, CEBPB, PECAM1, CCT8, ATP1A1, CRK, [NAME], DNM2, HGS, ABL1, GRB2, MAPK3, IKBKB, CREBBP, FYN, RELA, PXN, NEDD9, SRC | 1.4091984634e-06
TCR signaling in na&#xef;ve CD4+ T cells | PID | 71 | FLNA, SHC1, PTEN, CDC42 | 0.0249198523019 | AKT1, HRAS, FYN, GRB2, IKBKB, SHC1, CD4, PDPK1, CDC42 | 0.00101414215318
TCR signaling in na&#xef;ve CD8+ T cells | PID | 56 |  |  | AKT1, HLA-A, [NAME], HRAS, FYN, GRB2, IKBKB, SHC1, B2M | 2.76451576682e-05
TCR Signaling Pathway | Wikipathways | 91 | CDC42, CREB1, RELA, MAP3K7, JUN, SHC1, FAS | 0.00496299134571 | PDPK1, PRKCD, CDC42, MAPK3, CD4, VIM, CRK, HRAS, FOS, IKBKB, RELA, GRB2, JUN, AKT1, SHC1, FYN | 8.09053661555e-08
telomeres telomerase cellular aging and immortality | PID | 16 |  |  | AKT1, TERT, XRCC6, POLR2A | 0.00781940027808
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | Reactome | 12 | [NAME], HSP90AA1, [NAME], CALM3 | 0.00330436188925 | AKT1, [NAME], [NAME], CALM3 | 0.0144868510133
TGF beta Signaling Pathway | Wikipathways | 117 | UBE2I, PTK2, CDC42, UCHL5, COPS5, RAC1, RHOA, SUMO1, [NAME], MAP3K7, MYC, JUN, ITGB1, HDAC1, SHC1 | 2.82205590367e-05 | UBE2I, CDC42, SRC, NEDD9, CCND1, HGS, PJA1, GRB2, RAC1, [NAME], RHOA, TERT, CAV1, [NAME], JUNB, JUND, FOS, AKT1, SHC1 | 5.0345264242e-06 | filter
TGF Beta Signaling Pathway | Wikipathways | 55 |  |  | SMAD1, JUN, HRAS, MAPK3, STAT3, FOS, CREBBP | 0.0144868510133
TGF_beta_Receptor | NetPath | 179 | [NAME], [NAME], COPS5, HDAC1, [NAME], UBE2I, MAP3K7, KPNB1, CTNNB1, SUMO1, PTK2, PXN, CDKN1A, RHOA, MYC, UBE2D3 | 0.0010580828759 | AKT1, JUN, CCND1, UBE2D2, VDR, PJA1, EWSR1, FOS, CAV1, UBE2I, CRK, MAPK3, HGS, CDK4, [NAME], CREBBP, JUND, PXN, CDKN1A, RHOA, [NAME] | 3.95541581104e-05 | filter
the igf-1 receptor and longevity | PID | 16 |  |  | SHC1, HRAS, [NAME], GRB2, AKT1 | 0.0144868510133
the information processing pathway at the ifn beta enhancer | PID | 29 |  |  | GTF2F1, CREBBP, POLR2A, RELA, SMARCA4, SMARCC2, JUN, ACTB | 0.000512005256097
The role of Nef in HIV-1 replication and disease pathogenesis | Reactome | 29 |  |  | HCK, FYN, HLA-A, ARF1, CD4, RAC1, B2M | 0.00307415709423
Thromboxane A2 receptor signaling | PID | 57 | RHOA, EGFR, RAB11A, RAC1, SLC9A3R1, GNA15 | 0.00137034443883 | AKT1, GNAI2, GNA11, RHOA, HCK, SRC, TGM2, FYN, EGFR, PRKCZ, RAC1, PRKCD | 1.93342810337e-05
TLR JNK | INOH | 62 |  |  | PSMB3, IRAK1, JUN, MYD88, PSMB1, PSMD4, TOLLIP, TMEM189-UBE2V1 | 0.0196632428826
TLR NFkB | INOH | 69 |  |  | PSMB3, JUN, MYD88, IKBKB, IRAK1, RELA, PSMB1, PSMD4, TOLLIP, TMEM189-UBE2V1 | 0.00977716988666
TNF alpha Signaling Pathway | Wikipathways | 87 | HSP90AA1, BCL2L1, RAC1, TXN, MAP3K7, JUN, CSNK2A1 | 0.00797266506948 | IKBKB, PRKCZ, MAPK3, CREBBP, BCL2L1, TNFRSF1A, RAC1, GRB2, [NAME], [NAME], GLUL, AKT1 | 0.000298134142131 | filter
TNF receptor signaling pathway | PID | 46 | [NAME], RELA, MAP3K7, TXN, GNB2L1 | 0.00791876054924 | SQSTM1, TNFRSF1A, [NAME], RELA, IKBKB, PRKCZ, [NAME], GNB2L1 | 9.92409925423e-05 | filter
TNFalpha | NetPath | 211 | JUN, [NAME], RB1, FLNA, EGFR, CSNK2A1, CREB1, HSP90AB1, YWHAQ, UBE2I, TRIB3, [NAME], DDX3X, [NAME], MAP3K7, GNB2L1, KPNA2, RPL6, CAV1, SUMO1, HSP90AA1, RELA, YWHAZ, KPNA3, HDAC2, UBE2D3 | 3.72675684591e-06 | AKT1, JUN, EGFR, SMARCC2, [NAME], [NAME], UBE2D2, TNFRSF1A, SRC, SMARCA4, PRKCZ, FADD, UBE2I, [NAME], IKBKB, GNB2L1, RPS13, CREBBP, [NAME], [NAME], MAPK3, RELA, [NAME], MCC, [NAME] | 8.41637705443e-06 | filter
Toll Like Receptor 10 (TLR10) [NAME] | Reactome | 76 |  |  | IRAK1, JUN, MAPK3, MYD88, FOS, RELA, IKBKB, RPS6KA2, TMEM189-UBE2V1 | 0.00781940027808
Toll Like Receptor 2 (TLR2) [NAME] | Reactome | 82 |  |  | IRAK1, JUN, FOS, MYD88, RELA, IKBKB, RPS6KA2, MAPK3, TMEM189-UBE2V1 | 0.00781940027808
Toll Like Receptor 3 (TLR3) Cascade | Reactome | 72 | JUN, HMGB1, RELA, CREB1, [NAME], MAP3K7 | 0.0249198523019
Toll Like Receptor 4 (TLR4) Cascade | Reactome | 94 |  |  | IRAK1, JUN, MYD88, FOS, TMEM189-UBE2V1, IKBKB, MAPK3, RELA, RPS6KA2 | 0.012313349942
Toll Like Receptor 5 (TLR5) Cascade | Reactome | 76 |  |  | IRAK1, JUN, MAPK3, MYD88, FOS, RELA, IKBKB, RPS6KA2, TMEM189-UBE2V1 | 0.00781940027808
Toll Like Receptor 7/8 (TLR7/8) Cascade | Reactome | 79 |  |  | IRAK1, JUN, MAPK3, MYD88, FOS, IKBKB, RELA, RPS6KA2, TMEM189-UBE2V1 | 0.00977716988666
Toll Like Receptor 9 (TLR9) Cascade | Reactome | 83 |  |  | IRAK1, JUN, MYD88, FOS, IKBKB, RELA, RPS6KA2, MAPK3, TMEM189-UBE2V1 | 0.00977716988666
Toll Like Receptor TLR1:TLR2 [NAME] | Reactome | 82 |  |  | IRAK1, JUN, FOS, MYD88, RELA, IKBKB, RPS6KA2, MAPK3, TMEM189-UBE2V1 | 0.00781940027808
Toll Like Receptor TLR6:TLR2 [NAME] | Reactome | 82 |  |  | IRAK1, JUN, FOS, MYD88, RELA, IKBKB, RPS6KA2, MAPK3, TMEM189-UBE2V1 | 0.00781940027808
toll-like receptor pathway | PID | 36 | JUN, RELA, MAP3K7, TOLLIP | 0.00330436188925 | IRAK1, JUN, MYD88, RELA, IKBKB, FOS, TOLLIP | 0.00181177682958
Toll-like receptor signaling pathway | Wikipathways | 102 | RAC1, MAP3K7, JUN, TOLLIP, RELA | 0.0163620818244 | IRAK1, IKBKB, MAPK3, RAC1, [NAME], [NAME], TOLLIP, FOS, MYD88, AKT1, RELA | 0.000186512042959
TOR signaling | Wikipathways | 34 |  |  | RHEB, PRKAB1, TSC2, AKT1, CDC42, RAC1 | 0.0179633317051
TP53 network | Wikipathways | 19 | SUMO1, CDKN2A, CDKN1A, MYC | 0.00675203838849
tpo signaling pathway | PID | 25 | JUN, SHC1, CSNK2A1 | 0.0249198523019 | JUN, STAT5B, HRAS, MAPK3, GRB2, FOS, SHC1, STAT3 | 8.31515039956e-06
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | Reactome | 78 |  |  | IRAK1, JUN, MAPK3, MYD88, FOS, IKBKB, RELA, RPS6KA2, TMEM189-UBE2V1 | 0.00977716988666
TRAF6 Mediated Induction of proinflammatory cytokines | Reactome | 65 | JUN, HMGB1, CREB1, RELA, [NAME], MAP3K7 | 0.0249198523019 | IRAK1, JUN, MAPK3, IKBKB, FOS, RELA, RPS6KA2 | 0.0196222321142
transcription factor creb and its extracellular signals | PID | 27 |  |  | AKT1, PDPK1, SHC1, HRAS, MAPK3, GRB2 | 0.0014466921551
Transcription of the HIV genome | PID | 60 |  |  | POLR2A, TAF11, POLR2E, [NAME], POLR2C, GTF2F1, COBRA1, POLR2G | 0.0119214265967
trefoil factors initiate mucosal healing | PID | 37 | RHOA, RELA, EGFR, SHC1, CTNNB1 | 0.0163620818244 | AKT1, [NAME], RHOA, HRAS, MAPK3, RELA, EGFR, GRB2, ERBB2, IKBKB, SHC1 | 1.44565862173e-05
TRIF mediated TLR3 signaling | Reactome | 72 | JUN, HMGB1, RELA, CREB1, [NAME], MAP3K7 | 0.0249198523019
Trk receptor signaling mediated by PI3K and PLC-gamma | PID | 37 |  |  | AKT1, [NAME], CCND1, SRC, HRAS, GRB2, SFN, SHC1, [NAME], PRKCD | 8.31515039956e-06
trka receptor signaling pathway | PID | 13 |  |  | SHC1, HRAS, [NAME], GRB2, AKT1 | 0.000512005256097
TSH | NetPath | 26 |  |  | GNA11, GNAI2, ATP1A1, HRAS, MAPK3, IKBKB, CALR | 0.000361350243226
TSH signaling pathway | Wikipathways | 65 | RB1, MYC, JUN, APEX1, RPS6, CREB1 | 0.0171663609324 | PDPK1, AKT1, RALGDS, CDK4, GNAI2, JUN, SRC, MAPK3, STAT3, FOS, HRAS | 0.000111707027259
TSLP | NetPath | 19 |  |  | STAT6, STAT5B, AKT1, MAPK3, RELA, STAT3 | 0.000510480405482
TSLP Signaling Pathway | Wikipathways | 38 |  |  | AKT1, STAT6, MAPK3, STAT3, STAT5B, RELA | 0.0129798766226
tsp-1 induced apoptosis in microvascular endothelial cell | PID | 7 |  |  | FYN, JUN, FOS | 0.00977716988666
tumor suppressor arf inhibits ribosomal biogenesis | PID | 24 | RB1, HSP90AA1, RAC1, MYC, CDKN2A | 0.00325548104523 | AKT1, HSPA1A, [NAME], RAC1, [NAME] | 0.00954441103043
TWEAK | NetPath | 27 |  |  | AKT1, MAPK3, RELA, IKBKB, RAC1, FADD | 0.00554461619866
TWEAK Signaling Pathway | Wikipathways | 42 | HDAC1, JUN, MAP3K7, CTNNB1, RELA, RAC1 | 0.00238876218746 | JUN, IKBKB, AKT1, FADD, RELA, MAPK3, RAC1 | 0.00307415709423
ucalpain and friends in cell spread | PID | 17 | RHOA, PTK2, EZR, RAC1, PXN, ITGB1 | 0.00137034443883 | RHOA, SRC, EZR, RAC1, PXN, TLN1, CAPN1 | 0.00181177682958
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | PID | 44 | NCL, ITGA3, EGFR, RAC1, PLAU, FN1, ITGB1 | 0.00154345737728 | SRC, EGFR, RAC1, CRK, ITGB2, LRP1, [NAME], FN1 | 0.00182149911501
Validated nuclear estrogen receptor alpha network | PID | 66 | ANP32A, JUN, [NAME], PCNA, MYC | 0.0258973656068
Validated targets of C-MYC transcriptional activation | PID | 88 | NCL, TAF9, NPM1, [NAME], HSPD1, HSPA4, GAPDH, RCC1, HSP90AA1, MYC | 0.00986499156799
Validated targets of C-MYC transcriptional repression | PID | 75 | CREB1, HDAC1, CDKN1A, MYC, ITGB1, HDAC3 | 0.0219151018017
VEGF | INOH | 186 |  |  | AKT1, IRAK1, KDR, EGFR, PRKCD, FGFR1, SRC, PRKCZ, FYN, IKBKB, CDK4, PRKAB1, [NAME], MAPK3, RPS6KA2, [NAME] | 0.000732009954578
[NAME] and angiogenesis | PID | 30 | HSP90AA1, SHC1, PTK2, PXN, HIF1A, [NAME], VEGFA | 4.90968288472e-05 | KDR, [NAME], AKT1, SRC, HRAS, GRB2, SHC1, PXN, [NAME] | 8.41637705443e-06
VEGFR1 specific signals | PID | 31 | [NAME], [NAME], HSP90AA1, CALM3, HIF1A, [NAME], VEGFA | 0.000394874748464 | AKT1, [NAME], [NAME], MAPK3, [NAME], CALM3, CAV1 | 0.000361350243226
VEGFR3 signaling in lymphatic endothelium | PID | 25 | SHC1, CREB1, FN1, ITGB1 | 0.0249198523019 | AKT1, MAPK3, GRB2, SHC1, CRK, FN1 | 0.00920594382689
Viral Messenger RNA Synthesis | PID | 14 |  |  | POLR2E, POLR2C, GTF2F1, POLR2G, POLR2A | 0.0144868510133
Wnt | NetPath | 68 | CDH1, RHOA, CTNNB1, RAC1, [NAME], MAP3K7 | 0.0171663609324 | CTBP1, CCND1, DVL1, AKT1, RHOA, [NAME], RAC1, JUN, JUP, SMAD1, [NAME], LRP1, [NAME], ILK, TCF7L2 | 9.96710983392e-08
wnt signaling pathway | PID | 31 | HDAC1, CSNK2A1, MAP3K7, MYC, CTNNB1 | 0.00545242500279 | CTBP1, [NAME], CCND1, DVL1, CREBBP, [NAME] | 0.00554461619866
[NAME] | Wikipathways | 60 | PLAU, JUN, CTNNB1, RHOA, MYC, PAFAH1B1, RAC1 | 0.00496299134571 | CCND1, JUN, PRKCD, DVL1, [NAME], RHOA, PRKCZ, RAC1 | 0.000243323451392
[NAME] and Pluripotency | Wikipathways | 98 | CTNNB1, RHOA, PLAU, PAFAH1B1, MAP3K7, MYC, JUN, CTBP2, PPP2R1A | 0.00531567151148 | PRKCD, PRKCZ, CREBBP, CCND1, CTBP1, DVL1, TCF7L2, RHOA, JUN, CTBP2, [NAME] | 0.000512005256097