Spreadsheet: 0e26dee2-3d59-4bf4-8733-b59e20dedf48
Sheet: Reaction detail

ID | Reaction ID in KEGG | Name in KEGG | Preferred Name in KEGG | Definition in KEGG | Eqaution in KEGG | Reversiblity in network | direction | compartment | GeneId | Ecnumber | [NAME] in IMG | RecName in IMG | [NAME] | COFACTOR in UniprotKB | uniprot-pathway | uniprot-Status | [NAME] in UniprotKB | Comment | Source1 | Source2
R0001 | R00093 | L-glutamate:NAD+ oxidoreductase (transaminating) | L-glutamate:NAD+ oxidoreductase (transaminating) | 2 L-Glutamate + NAD+ <=> L-Glutamine + 2-Oxoglutarate + NADH + H+ | 2 C00025 + C00003 <=> C00064 + C00026 + C00004 + C00080 | irev | Backward | c | YALI0B19998g | 1.4.1.14 | glutamate synthase (NADH) small subunit |  | Alanine, aspartate and glutamate metabolism | FMN |  | Unreviewed |  |  | IKU-differenceReaction | 1-n-n
R0002 | R00114 | L-Glutamate:NADP+ oxidoreductase (transaminating) | L-Glutamate:NADP+ oxidoreductase (transaminating) | 2 L-Glutamate + NADP+ <=> L-Glutamine + 2-Oxoglutarate + NADPH + H+ | 2 C00025 + C00006 <=> C00064 + C00026 + C00005 + C00080 | irev | Backward | c | YALI0B19998g | 1.4.1.13 | glutamate synthase (NADH) small subunit |  | Alanine, aspartate and glutamate metabolism | FAD; FMN; Iron-sulfur. |  | Unreviewed |  | Formerly EC 2.6.1.53. | IKU-differenceReaction | 1-n-n
R0003 | R00243 | L-Glutamate:NAD+ oxidoreductase (deaminating) | L-Glutamate:NAD+ oxidoreductase (deaminating) | L-Glutamate + NAD+ + H2O <=> 2-Oxoglutarate + NH3 + NADH + H+ | C00025 + C00003 + C00001 <=> C00026 + C00014 + C00004 + C00080 | r |  | c | YALI0E09603g | 1.4.1.2 | glutamate dehydrogenase (NAD) |  | Alanine, aspartate and glutamate metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0004 | R00248 | L-Glutamate:NADP+ oxidoreductase (deaminating) | L-Glutamate:NADP+ oxidoreductase (deaminating) | L-Glutamate + NADP+ + H2O <=> 2-Oxoglutarate + NH3 + NADPH + H+ | C00025 + C00006 + C00001 <=> C00026 + C00014 + C00005 + C00080 | r |  | c | [NAME] | 1.4.1.4 | glutamate dehydrogenase (NADP) |  | Alanine, aspartate and glutamate metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0005 | R00253 | L-Glutamate:ammonia ligase (ADP-forming) | L-Glutamate:ammonia ligase (ADP-forming) | ATP + L-Glutamate + NH3 <=> ADP + Orthophosphate + L-Glutamine | C00002 + C00025 + C00014 <=> C00008 + C00009 + C00064 | irev | Forward | c | YALI0D13024g OR YALI0F00506g | 6.3.1.2 |  |  | Alanine, aspartate and glutamate metabolism |  |  |  |  |  | IKU-IKUReaction | n-1-1
R0006 | R00258 | L-Alanine:2-oxoglutarate aminotransferase | L-Alanine:2-oxoglutarate aminotransferase | L-Alanine + 2-Oxoglutarate <=> Pyruvate + L-Glutamate | C00041 + C00026 <=> C00022 + C00025 | r |  | c | YALI0D06325g | 2.6.1.2 | L-alanine aminotransferase apoenzyme |  | Alanine, aspartate and glutamate metabolism | Pyridoxal 5'-phosphate. |  |  |  | 2-aminobutanoate acts slowly instead of alanine. | IKU-IKReaction | 1-1-1
R0007 | R00355 | L-Aspartate:2-oxoglutarate aminotransferase | L-Aspartate:2-oxoglutarate aminotransferase | L-Aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-Glutamate | C00049 + C00026 <=> C00036 + C00025 | r |  | c | YALI0B02178g OR YALI0F29337g | 2.6.1.1 | hypothetical protein | Aspartate aminotransferase | Alanine, aspartate and glutamate metabolism | Pyridoxal phosphate (By similarity). |  | Unreviewed |  | Also acts on L-tyrosine, L-phenylalanine and L-tryptophan.This activity can be formed from EC 2.6.1.57 by controlled proteolysis. | IKU-IKUReaction | n-1-n
R0008 | R00369 | L-Alanine:glyoxylate aminotransferase | L-Alanine:glyoxylate aminotransferase | L-Alanine + Glyoxylate <=> Pyruvate + Glycine | C00041 + C00048 <=> C00022 + C00037 | r |  | c | YALI0E16643g | 2.6.1.44 | alanine-glyoxylate aminotransferase apoenzyme |  | Alanine, aspartate and glutamate metabolism | Pyridoxal 5'-phosphate. |  | Unreviewed |  | With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate.A second component also catalyzes the reaction of EC 2.6.1.51. | IKU-differenceReaction | 1-n-n
R0009 | R00578 | L-aspartate:L-glutamine amido-ligase (AMP-forming) | L-aspartate:L-glutamine amido-ligase (AMP-forming) | ATP + L-Aspartate + L-Glutamine + H2O <=> AMP + Diphosphate + L-Asparagine + L-Glutamate | C00002 + C00049 + C00064 + C00001 <=> C00020 + C00013 + C00152 + C00025 | irev | Forward | c | YALI0A13387g | 6.3.5.4 | hypothetical protein |  | Alanine, aspartate and glutamate metabolism |  |  |  |  | The enzyme from Escherichia coli has two active sites that are connected by an intramolecular ammonia tunnel.The enzyme catalyzes three distinct chemical reactions: glutamine hydrolysis to yield ammonia takes place in the N-terminal domain.The C-terminal active site mediates both the synthesis of a beta- aspartyl-AMP intermediate and its subsequent reaction with ammonia.The ammonia released is channeled to the other active site to yield asparagine. | IKU-IKReaction | 1-1-1
[NAME] | R00707 | (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase | (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase | (S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O <=> L-Glutamate + NADH + H+ | C03912 + C00003 + 2 C00001 <=> C00025 + C00004 + C00080 | irev | Forward | c | YALI0B09647g | 1.5.1.12 | hypothetical protein |  | Alanine, aspartate and glutamate metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0011 | R00708 | (S)-1-pyrroline-5-carboxylate:NADP+ oxidoreductase | (S)-1-pyrroline-5-carboxylate:NADP+ oxidoreductase | (S)-1-Pyrroline-5-carboxylate + NADP+ + 2 H2O <=> L-Glutamate + NADPH + H+ | C03912 + C00006 + 2 C00001 <=> C00025 + C00005 + C00080 | irev | Forward | c | YALI0B09647g | 1.5.1.12 | hypothetical protein |  | Alanine, aspartate and glutamate metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0026 | R00416 | UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase | UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase | UTP + N-Acetyl-alpha-D-glucosamine 1-phosphate <=> Diphosphate + UDP-N-acetyl-D-glucosamine | C00075 + C04501 <=> C00013 + C00043 | irev | Forward | c | [NAME] | 2.7.7.23 | hypothetical protein |  | Amino sugar and nucleotide sugar metabolism |  |  |  |  | The enzyme from several bacteria has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157. | IKU-IKReaction | 1-1-1
R0027 |  | D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing); D-glucosamine-6-phosphate ketol-isomerase(deaminating) | D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing) | D-Glucosamine 6-phosphate + H2O <=> beta-D-Fructose 6-phosphate + NH3 | C00352 + C00001 <=> C05345 + C00014 | irev | Forward | c | [NAME] | 3.5.99.6 | hypothetical protein |  | Amino sugar and nucleotide sugar metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0028 |  | L-glutamine:D-fructose-6-phosphate isomerase (deaminating); L-glutamine:D-fructose-6-phosphate aminotransferase (hexose isomerizing) | L-glutamine:D-fructose-6-phosphate isomerase (deaminating) | L-Glutamine + beta-D-Fructose 6-phosphate <=> L-Glutamate + D-Glucosamine 6-phosphate | C00064 + C05345 <=> C00025 + C00352 | irev | Forward | c | [NAME] | 2.6.1.16 | hypothetical protein |  | Amino sugar and nucleotide sugar metabolism |  |  |  |  | Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination).Formerly EC 5.3.1.19. | IKU-IKReaction | 1-1-1
R0029 | R02058 | acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase | acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase | Acetyl-CoA + D-Glucosamine 6-phosphate <=> CoA + N-Acetyl-D-glucosamine 6-phosphate | C00024 + C00352 <=> C00010 + C00357 | irev | Forward | c | YALI0D20152g | 2.3.1.4 | glucosamine-phosphate N-acetyltransferase |  | Amino sugar and nucleotide sugar metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
[NAME] | R02059 | N-Acetyl-D-glucosamine-6-phosphate amidohydrolase | N-Acetyl-D-glucosamine-6-phosphate amidohydrolase | N-Acetyl-D-glucosamine 6-phosphate + H2O <=> D-Glucosamine 6-phosphate + Acetate | C00357 + C00001 <=> C00352 + C00033 | irev | Forward | c | YALI0E20163g | 3.5.1.25 | N-acetylglucosamine 6-phosphate deacetylase |  | Amino sugar and nucleotide sugar metabolism |  |  |  |  | Formerly EC 3.5.1.80. | IKU-IKReaction | 1-1-1
R0031 | R02335 | UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase | UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase | UDP-N-acetyl-D-glucosamine <=> UDP + Chitin | C00043 <=> C00015 + C00461 | irev | Forward | c | YALI0B16324g OR YALI0C24354g OR YALI0D03179g OR YALI0D25938g OR YALI0E22198g | 2.4.1.16 |  |  | Amino sugar and nucleotide sugar metabolism |  |  |  |  | Converts UDP-N-acetyl-D-glucosamine into chitin and UDP. | IKU-IKReaction | n-1-1
R0032 | R08193 | N-Acetyl-D-glucosamine 1-phosphate 1,6-phosphomutase | N-Acetyl-D-glucosamine 1-phosphate 1,6-phosphomutase | N-Acetyl-D-glucosamine 6-phosphate <=> N-Acetyl-alpha-D-glucosamine 1-phosphate | C00357 <=> C04501 | r |  | c | YALI0E29579g | 5.4.2.3 | phosphoacetylglucosamine mutase |  | Amino sugar and nucleotide sugar metabolism |  |  |  |  | Activated by N-acetyl-alpha-D-glucosamine 1,6-bisphosphate.Formerly EC 2.7.5.2. | IKU-IKReaction | 1-1-1
R0033 | R01961 | ATP:D-glucosamine 6-phosphotransferase | ATP:D-glucosamine 6-phosphotransferase | ATP + D-Glucosamine <=> ADP + D-Glucosamine 6-phosphate | C00002 + C00329 <=> C00008 + C00352 | r |  | c | YALI0B22308g OR [NAME] YALI0E20207g | 2.7.1.1 |  |  | Amino sugar and nucleotide sugar metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0034 | R01206 | [1,4-(N-Acetyl-beta-D-glucosaminyl)]n glycanohydrolase | [1,4-(N-Acetyl-beta-D-glucosaminyl)]n glycanohydrolase | Chitin + H2O <=> N-Acetyl-D-glucosamine | C00461 + C00001 <=> C00140 | irev | Forward | c | YALI0A01870g OR YALI0D22396g OR YALI0F04532g | 3.2.1.14 |  |  | Amino sugar and nucleotide sugar metabolism |  |  |  |  | Some chitinases also display the activity defined in EC 3.2.1.17. | IKU-IKReaction | n-1-n
R0041 | R00005 | urea-1-carboxylate amidohydrolase | urea-1-carboxylate amidohydrolase | Urea-1-carboxylate + H2O <=> 2 CO2 + 2 NH3 | C01010 + C00001 <=> 2 C00011 + 2 C00014 | irev | Forward | c | YALI0E07271g | 3.5.1.54 | hypothetical protein |  | Arginine and proline metabolism |  |  | Unreviewed |  | Along with EC 3.5.2.15 and EC 3.5.1.84, forms part of the cyanuric- acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine (2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5- triazine), in bacteria.The Saccharomyces cerevisiae enzyme (but not that from green algae) also catalyzes the reaction of EC 6.3.4.6, thus bringing about the hydrolysis of urea to CO(2) and NH(3) in the presence of ATP and bicarbonate.The enzyme from Pseudomonas sp. strain ADP has a narrow substrate specificity, being unable to use the structurally analogous compounds urea, hydroxyurea or methylcarbamate as substrate. | IKU-IKReaction | 1-n-n
R0042 | R00239 | ATP:L-glutamate 5-phosphotransferase | ATP:L-glutamate 5-phosphotransferase | ATP + L-Glutamate <=> ADP + L-Glutamyl 5-phosphate | C00002 + C00025 <=> C00008 + C03287 | irev | Forward | c | YALI0A19206g | 2.7.2.11 | glutamate 5-kinase |  | Arginine and proline metabolism |  |  |  |  | The product rapidly cyclizes to 5-oxoproline and phosphate. | IKU-IKReaction | 1-1-1
R0043 | R00245 | L-Glutamate 5-semialdehyde:NAD+ oxidoreductase | L-Glutamate 5-semialdehyde:NAD+ oxidoreductase | L-Glutamate 5-semialdehyde + NAD+ + H2O <=> L-Glutamate + NADH + H+ | C01165 + C00003 + C00001 <=> C00025 + C00004 + C00080 | irev | Forward | m | YALI0B09647g | 1.5.1.12 | hypothetical protein |  | Arginine and proline metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0044 | R00259 | acetyl-CoA:L-glutamate N-acetyltransferase | acetyl-CoA:L-glutamate N-acetyltransferase | Acetyl-CoA + L-Glutamate <=> CoA + N-Acetyl-L-glutamate | C00024 + C00025 <=> C00010 + C00624 | irev | Forward | m | YALI0B16390g OR YALI0E13057g | 2.3.1.1 | hypothetical protein | Amino-acid acetyltransferase, mitochondrial | Arginine and proline metabolism |  | Amino-acid biosynthesis L-arginine biosynthesis [NAME] from L-glutamate: step 1/4. | Reviewed | Mitochondrion (By similarity). |  | IK-IKReaction | 1-n-n
R0045 | R00551 | L-Arginine amidinohydrolase | L-Arginine amidinohydrolase | L-Arginine + H2O <=> L-Ornithine + Urea | C00062 + C00001 <=> C00077 + C00086 | irev | Forward | c | YALI0E07535g | 3.5.3.1 | arginase |  | Arginine and proline metabolism | Manganese. |  |  |  | Also hydrolyzes alpha-N-substituted L-arginines and canavanine. | IKU-IKReaction | 1-1-1
R0046 | R00667 | L-Ornithine:2-oxo-acid aminotransferase | L-Ornithine:2-oxo-acid aminotransferase | L-Ornithine + 2-Oxoglutarate <=> L-Glutamate 5-semialdehyde + L-Glutamate | C00077 + C00026 <=> C01165 + C00025 | irev | Forward | c | YALI0C04433g | 2.6.1.13 | hypothetical protein |  | Arginine and proline metabolism | Pyridoxal 5'-phosphate. |  |  |  |  | IKU-IKReaction | 1-1-1
R0047 | R00670 | L-ornithine carboxy-lyase (putrescine-forming) | L-ornithine carboxy-lyase (putrescine-forming) | L-Ornithine <=> Putrescine + CO2 | C00077 <=> C00134 + C00011 | irev | Forward | c | YALI0B11330g | 4.1.1.17 | ornithine decarboxylase |  | Arginine and proline metabolism | Pyridoxal 5'-phosphate. |  |  |  |  | IKU-IKReaction | 1-1-1
[NAME] | R00774 | Urea:carbon-dioxide ligase (ADP-forming) | Urea:carbon-dioxide ligase (ADP-forming) | ATP + Urea + HCO3- <=> ADP + Orthophosphate + Urea-1-carboxylate | C00002 + C00086 + C00288 <=> C00008 + C00009 + C01010 | r |  | c | YALI0E07271g | 6.3.4.6 | hypothetical protein |  | Arginine and proline metabolism | Biotin. |  | Unreviewed |  | The Saccharomyces cerevisiae enzyme (but not that from green algae) also catalyzes the reaction of EC 3.5.1.54, thus bringing about the hydrolysis of urea to CO(2) and NH(3).The enzyme from the prokaryotic bacterium Oleomonas sagaranensis can also use acetamide and formamide as substrates.Formerly EC 3.5.1.45. | IKU-IKReaction | 1-n-n
R0049 | R01086 | 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming) | 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming) | N-(L-Arginino)succinate <=> Fumarate + L-Arginine | C03406 <=> C00122 + C00062 | r |  | c | YALI0D26367g | 4.3.2.1 | argininosuccinate lyase |  | Arginine and proline metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0050 | [NAME] | Agmatine amidinohydrolase | Agmatine amidinohydrolase | [NAME] <=> Putrescine + Urea | C00179 + C00001 <=> C00134 + C00086 | irev | Forward | c | YALI0E04202g | 3.5.3.11 | agmatinase |  | Arginine and proline metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0051 | R01248 | L-Proline:NAD+ 5-oxidoreductase | L-Proline:NAD+ 5-oxidoreductase | L-Proline + NAD+ <=> (S)-1-Pyrroline-5-carboxylate + NADH + H+ | C00148 + C00003 <=> C03912 + C00004 + C00080 | r |  | c | YALI0B14399g | 1.5.1.2 | pyrroline-5-carboxylate reductase | Pyrroline-5-carboxylate reductase | Arginine and proline metabolism |  | Amino-acid biosynthesis L-proline biosynthesis L- proline from L-glutamate 5-semialdehyde: step 1/1. | Unreviewed |  | Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline. | IKU-IKUReaction | 1-1-n
R0052 | R01251 | L-Proline:NADP+ 5-oxidoreductase | L-Proline:NADP+ 5-oxidoreductase | L-Proline + NADP+ <=> (S)-1-Pyrroline-5-carboxylate + NADPH + H+ | C00148 + C00006 <=> C03912 + C00005 + C00080 | r |  | c | YALI0B14399g | 1.5.1.2 | pyrroline-5-carboxylate reductase | Pyrroline-5-carboxylate reductase | Arginine and proline metabolism |  | Amino-acid biosynthesis L-proline biosynthesis L- proline from L-glutamate 5-semialdehyde: step 1/1. | Unreviewed |  | Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline. | IKU-IKUReaction | 1-1-n
R0053 | R01398 | Carbamoyl-phosphate:L-ornithine carbamoyltransferase | Carbamoyl-phosphate:L-ornithine carbamoyltransferase | Carbamoyl phosphate + L-Ornithine <=> Orthophosphate + L-Citrulline | C00169 + C00077 <=> C00009 + C00327 | irev | Forward | m | YALI0D14894g | 2.1.3.3 | ornithine carbamoyltransferase |  | Arginine and proline metabolism |  |  |  |  | The plant enzyme also catalyzes the reactions of EC 2.1.3.6, EC 2.7.2.2 and EC 3.5.3.12, thus acting as putrescine synthase, converting agmatine and ornithine into putrescine and citrulline respectively. | IKU-IKReaction | 1-1-1
R0054 | R02282 | N2-Acetyl-L-ornithine:L-glutamate N-acetyltransferase | N2-Acetyl-L-ornithine:L-glutamate N-acetyltransferase | N-Acetylornithine + L-Glutamate <=> L-Ornithine + N-Acetyl-L-glutamate | C00437 + C00025 <=> C00077 + C00624 | r |  | m | YALI0E13057g | 2.3.1.35 | N-acetylglutamate synthase |  | Arginine and proline metabolism |  |  |  |  | Also has some hydrolytic activity on acetyl-L-ornithine, but the rate is 1% of that of transferase activity. | IK-IKReaction | 1-n-n
R0055 | R02283 | N2-Acetyl-L-ornithine:2-oxoglutarate aminotransferase | N2-Acetyl-L-ornithine:2-oxoglutarate aminotransferase | N(2)-Acetylornithine + 2-Oxoglutarate <=> N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamate | C00437 + C00026 <=> C01250 + C00025 | irev | Backward | m | YALI0D22847g | 2.6.1.11 | acetylornithine aminotransferase apoenzyme | Acetylornithine aminotransferase, mitochondrial | Arginine and proline metabolism | Pyridoxal 5'-phosphate. | Amino-acid biosynthesis L-arginine biosynthesis [NAME] from L-glutamate: step 4/4. | Reviewed | Mitochondrion matrix (By similarity). | Also acts on L-ornithine and N(2)-succinyl-L-ornithine. | IKU-IKUReaction | 1-1-1
R0056 | R02549 | 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase | 4-aminobutanal:NAD+ 1-oxidoreductase | 4-Aminobutyraldehyde + NAD+ + H2O <=> 4-Aminobutanoate + NADH + H+ | C00555 + C00003 + C00001 <=> C00334 + C00004 + C00080 | irev | Forward | c | YALI0B01298g OR YALI0C03025g OR YALI0E00264g OR YALI0F23793g | 1.2.1.3 |  |  | Arginine and proline metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0057 | R02649 | ATP:N-acetyl-L-glutamate 5-phosphotransferase | ATP:N-acetyl-L-glutamate 5-phosphotransferase | ATP + N-Acetyl-L-glutamate <=> ADP + N-Acetyl-L-glutamate 5-phosphate | C00002 + C00624 <=> C00008 + C04133 | irev | Forward | m | YALI0B17666g | 2.7.2.8 | N-acetyl-gamma-glutamyl-phosphate reductase |  | Arginine and proline metabolism |  | Amino-acid biosynthesis L-arginine biosynthesis [NAME] from L-glutamate. | Unreviewed |  |  | IKU-differenceReaction | 1-n-n
R0058 | R02869 | S-adenosylmethioninamine:spermidine 3-aminopropyltransferase | S-adenosylmethioninamine:spermidine 3-aminopropyltransferase | S-Adenosylmethioninamine + Spermidine <=> 5'-Methylthioadenosine + Spermine | [NAME] <=> C00170 + C00750 | r |  | c | YALI0E33143g | 2.5.1.16 | spermine synthase |  | Arginine and proline metabolism |  |  | Unreviewed |  | The mammalian enzyme is highly specific but the bacterial enzyme can use other acceptors and can synthesize spermine.Not identical with EC 2.5.1.22. | IKU-differenceReaction | 1-1-n
R0064 | [NAME] | L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) | L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) | L-Glutamate 5-semialdehyde + Orthophosphate + NADP+ <=> L-Glutamyl 5-phosphate + NADPH + H+ | C01165 + C00009 + C00006 <=> C03287 + C00005 + C00080 | irev | Backward | c | [NAME] | 1.2.1.41 | glutamate-5-semialdehyde dehydrogenase |  | Arginine and proline metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0065 | R03443 | N-Acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphrylating) | N-Acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphrylating) | N-Acetyl-L-glutamate 5-semialdehyde + Orthophosphate + NADP+ <=> N-Acetyl-L-glutamate 5-phosphate + NADPH + H+ | C01250 + C00009 + C00006 <=> C04133 + C00005 + C00080 | irev | Backward | m | YALI0B17666g | 1.2.1.38 | N-acetyl-gamma-glutamyl-phosphate reductase |  | Arginine and proline metabolism |  | Amino-acid biosynthesis L-arginine biosynthesis [NAME] from L-glutamate. | Unreviewed |  |  | IKU-differenceReaction | 1-n-n
R0071 | R00707 | (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase | (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase | (S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O <=> L-Glutamate + NADH + H+ | C03912 + C00003 + 2 C00001 <=> C00025 + C00004 + C00080 | irev | Forward | c | YALI0B09647g | 1.5.1.12 | hypothetical protein |  | Arginine and proline metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0072 | R03314 | NO NAME | NO NAME | L-Glutamate 5-semialdehyde <=> (S)-1-Pyrroline-5-carboxylate + H2O | C01165 <=> C03912 + C00001 | r |  | c |  |  |  |  | Arginine and proline metabolism |  |  |  |  | spontaneous reaction
R0075 | R00489 | L-aspartate 1-carboxy-lyase (beta-alanine-forming) | L-aspartate 1-carboxy-lyase (beta-alanine-forming) | L-Aspartate <=> beta-Alanine + CO2 | C00049 <=> C00099 + C00011 | irev | Forward | c | YALI0F08415g | 4.1.1.15 | glutamate decarboxylase |  | beta-Alanine metabolism | Pyridoxal 5'-phosphate. |  |  |  | The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate. | IKU-IKReaction | 1-1-n
R0076 | R00904 | 3-aminopropanal:NAD+ oxidoreductase | 3-aminopropanal:NAD+ oxidoreductase | 3-Aminopropanal + NAD+ + H2O <=> beta-Alanine + NADH + H+ | C05665 + C00003 + C00001 <=> C00099 + C00004 + C00080 | irev | Forward | c | ( YALI0D07942g OR YALI0F04444g ) OR ( YALI0B01298g OR YALI0C03025g OR YALI0E00264g OR YALI0F23793g ) | 1.2.1.5 OR 1.2.1.3 |  |  | beta-Alanine metabolism |  |  |  |  |  | IKU-differenceReaction OR IKU-IKReaction | n-1-n OR n-1-n
R0078 | R03139 | primary-amine oxidase | primary-amine oxidase | 1,3-Diaminopropane + Oxygen + H2O <=> 3-Aminopropanal + NH3 + Hydrogen peroxide | C00986 + C00007 + C00001 <=> C05665 + C00014 + C00027 | irev | Forward | c | YALI0C18315g OR YALI0C22792g | 1.4.3.21 |  |  | beta-Alanine metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0079 | R00177 | ATP:L-methionine S-adenosyltransferase | ATP:L-methionine S-adenosyltransferase | Orthophosphate + Diphosphate + S-Adenosyl-L-methionine <=> ATP + L-Methionine + H2O | C00009 + C00013 + C00019 <=> C00002 + C00073 + C00001 | irev | Backward | c | [NAME] | 2.5.1.6 | methionine adenosyltransferase | S-adenosylmethionine synthase | Cysteine and methionine metabolism | Binds 2 divalent ions per subunit. Magnesium or cobalt (By similarity). | Amino-acid biosynthesis S-adenosyl-L-methionine biosynthesis S-adenosyl-L-methionine from L-methionine: step 1/1. | Unreviewed |  | Formerly EC 2.4.2.13. | IKU-IKUReaction | 1-1-1
[NAME] | R00178 | S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-forming] | S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-forming] | S-Adenosyl-L-methionine + H+ <=> S-Adenosylmethioninamine + CO2 | C00019 + C00080 <=> C01137 + C00011 | irev | Forward | c | YALI0E20361g | 4.1.1.50 | hypothetical protein |  | Cysteine and methionine metabolism | Pyruvate. |  |  |  |  | IKU-IKReaction | 1-1-1
R0081 | R00192 | S-Adenosyl-L-homocysteine hydrolase | S-Adenosyl-L-homocysteine hydrolase | S-Adenosyl-L-homocysteine + H2O <=> Adenosine + L-Homocysteine | C00021 + C00001 <=> C00212 + C00155 | irev | Forward | c | YALI0F11759g | 3.3.1.1 | adenosylhomocysteinase | Adenosylhomocysteinase | Cysteine and methionine metabolism | NAD (By similarity). | Amino-acid biosynthesis homocysteine biosynthesis L- homocysteine from S-adenosyl-L-homocysteine: step 1/1. | Unreviewed |  | The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4. | IKU-IKUReaction | 1-1-1
R0082 | R00650 | S-Adenosyl-L-methionine:L-homocysteine S-methyltransferase | S-Adenosyl-L-methionine:L-homocysteine S-methyltransferase | S-Adenosyl-L-methionine + L-Homocysteine <=> S-Adenosyl-L-homocysteine + L-Methionine | C00019 + C00155 <=> C00021 + C00073 | irev | Forward | c | YALI0F25641g | 2.1.1.10 | homocysteine S-methyltransferase |  | Cysteine and methionine metabolism |  |  |  |  | The enzyme uses S-adenosyl-L-methionine as methyl donor less actively than S-methyl-L-methionine. | IKU-IKReaction | 1-1-1
R0083 | R00782 | L-Cysteine hydrogen-sulfide-lyase (deaminating; pyruvate-forming) | L-Cysteine hydrogen-sulfide-lyase (deaminating; pyruvate-forming) | L-Cysteine + H2O <=> Hydrogen sulfide + Pyruvate + NH3 | C00097 + C00001 <=> C00283 + C00022 + C00014 | r |  | c | YALI0D00605g　OR YALI0F05874g | 4.4.1.8 OR 4.4.1.1 | hypothetical protein OR cystathionine gamma-lyase |  | Cysteine and methionine metabolism | Pyridoxal 5'-phosphate. OR Pyridoxal 5'-phosphate. |  |  |  | The enzyme from some sources also acts on L-cystine, forming pyruvate, ammonia and cysteine persulfide, and a number of related compounds.Possibly identical, in Saccharomyces cerevisiae, with EC 4.4.1.6. | IKU-IKReaction OR IKU-IKReaction | 1-1-n OR 1-1-n
R0084 | R00893 | L-Cysteine:oxygen oxidoreductase | L-Cysteine:oxygen oxidoreductase | L-Cysteine + Oxygen <=> 3-Sulfino-L-alanine | C00097 + C00007 <=> C00606 | irev | Forward | c | YALI0F11627g | 1.13.11.20 | hypothetical protein |  | Cysteine and methionine metabolism | Iron; NAD(P)H. |  |  |  |  | IKU-IKReaction | 1-1-1
R0085 | R00895 | L-Cysteine:2-oxoglutarate aminotransferase | L-Cysteine:2-oxoglutarate aminotransferase | L-Cysteine + 2-Oxoglutarate <=> Mercaptopyruvate + L-Glutamate | C00097 + C00026 <=> C00957 + C00025 | r |  | c | YALI0B02178g OR YALI0F29337g | 2.6.1.1 | hypothetical protein | Aspartate aminotransferase | Cysteine and methionine metabolism | Pyridoxal phosphate (By similarity). |  | Unreviewed |  | Also acts on L-tyrosine, L-phenylalanine and L-tryptophan.This activity can be formed from EC 2.6.1.57 by controlled proteolysis. | IKU-IKUReaction | n-1-n
R0086 | [NAME] | O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase; O3-acetyl-L-serine acetate-lyase (adding hydrogen sulfide) | O3-acetyl-L-serine acetate-lyase (adding hydrogen sulfide) | [NAME] + Hydrogen sulfide <=> L-Cysteine + Acetate | C00979 + C00283 <=> C00097 + C00033 | irev | Forward | c | YALI0E08536g OR YALI0F14047g | 2.5.1.47 | hypothetical protein | Cysteine synthase | Cysteine and methionine metabolism | Pyridoxal 5'-phosphate. |  | Unreviewed |  | Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors.Not identical with EC 2.5.1.51, EC 2.5.1.52 and EC 2.5.1.53.Formerly EC 4.2.99.8. | IKU-IKUReaction | n-1-n
R0087 | [NAME] | O-Succinyl-L-homoserine succinate-lyase (deaminating; 2-oxobutanoate-forming) | O-Succinyl-L-homoserine succinate-lyase (deaminating; 2-oxobutanoate-forming) | O-Succinyl-L-homoserine + H2O <=> 2-Oxobutanoate + Succinate + NH3 | C01118 + C00001 <=> C00109 + C00042 + C00014 | r |  | c | YALI0C22088g OR YALI0D17402g | 2.5.1.48 |  |  | Cysteine and methionine metabolism | Pyridoxal 5'-phosphate. |  |  |  | Also reacts with H(2)S and methanethiol as replacing agents, producing homocysteine and methionine, respectively.In the absence of thiol, can also catalyze beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.Formerly EC 4.2.99.9. | IKU-IKReaction | n-1-n
R0088 | R01286 | L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming) | L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming) | L-Cystathionine + H2O <=> L-Homocysteine + NH3 + Pyruvate | C02291 + C00001 <=> C00155 + C00014 + C00022 | irev | Forward | c | YALI0D00605g | 4.4.1.8 | hypothetical protein |  | Cysteine and methionine metabolism | Pyridoxal 5'-phosphate. |  |  |  | The enzyme from some sources also acts on L-cystine, forming pyruvate, ammonia and cysteine persulfide, and a number of related compounds.Possibly identical, in Saccharomyces cerevisiae, with EC 4.4.1.6. | IKU-IKReaction | 1-1-n
R0089 | [NAME] | O-acetyl-L-homoserine:hydrogen sulfide S-(3-amino-3-carboxypropyl)transferase; O-acetyl-L-homoserine acetate-lyase (adding hydrogen sulfide) | O-acetyl-L-homoserine acetate-lyase (adding hydrogen sulfide) | O-Acetyl-L-homoserine + Hydrogen sulfide <=> L-Homocysteine + Acetate | C01077 + C00283 <=> C00155 + C00033 | irev | Forward | c | YALI0D25168g | 2.5.1.49 | O-acetylhomoserine sulfhydrolase |  | Cysteine and methionine metabolism | Pyridoxal phosphate (By similarity). |  | Unreviewed |  | Also reacts with other thiols and H(2)S, producing homocysteine or thioethers.The name methionine synthase is more commonly applied to EC 2.1.1.13.The enzyme from Saccharomyces cerevisiae also catalyzes the reaction of EC 2.5.1.47, but more slowly.Formerly EC 4.2.99.10. | IKU-differenceReaction | 1-1-n
R0090 | R01288 | O4-succinyl-L-homoserine:hydrogen sulfide S-(3-amino-3-carboxypropyl)transferase; O-succinyl-L-homoserine succinate-lyase (adding hydrogen sulfide) | O-succinyl-L-homoserine succinate-lyase (adding hydrogen sulfide) | O-Succinyl-L-homoserine + Hydrogen sulfide <=> L-Homocysteine + Succinate | C01118 + C00283 <=> C00155 + C00042 | irev | Forward | c | YALI0C22088g OR YALI0D17402g | 2.5.1.48 |  |  | Cysteine and methionine metabolism | Pyridoxal 5'-phosphate. |  |  |  | Also reacts with H(2)S and methanethiol as replacing agents, producing homocysteine and methionine, respectively.In the absence of thiol, can also catalyze beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.Formerly EC 4.2.99.9. | IKU-IKReaction | n-1-n
R0091 | R01402 | S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase | S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase | 5'-Methylthioadenosine + Orthophosphate <=> Adenine + S-Methyl-5-thio-D-ribose 1-phosphate | [NAME] <=> C00147 + C04188 | irev | Forward | c | YALI0B13420g | 2.4.2.28 | methylthioadenosine phosphorylase |  | Cysteine and methionine metabolism |  |  |  |  | Also acts on 5'-deoxyadenosine and other analogs having 5'-deoxy groups. | IKU-IKReaction | 1-1-1
R0092 | R01776 | Acetyl-CoA:L-homoserine O-acetyltransferase | Acetyl-CoA:L-homoserine O-acetyltransferase | Acetyl-CoA + L-Homoserine <=> CoA + O-Acetyl-L-homoserine | C00024 + C00263 <=> C00010 + C01077 | irev | Forward | c | [NAME]g OR YALI0E00836g | 2.3.1.31 |  |  | Cysteine and methionine metabolism |  |  |  |  |  | IKU-IKReaction | n-1-1
R0093 | R01920 | S-adenosylmethioninamine:putrescine 3-aminopropyltransferase | S-adenosylmethioninamine:putrescine 3-aminopropyltransferase | S-Adenosylmethioninamine + Putrescine <=> 5'-Methylthioadenosine + Spermidine | C01137 + C00134 <=> [NAME] | irev | Forward | c | YALI0E33143g | 2.5.1.16 | spermine synthase |  | Cysteine and methionine metabolism |  |  | Unreviewed |  | The mammalian enzyme is highly specific but the bacterial enzyme can use other acceptors and can synthesize spermine.Not identical with EC 2.5.1.22. | IKU-differenceReaction | 1-1-n
R0094 | R02026 | O-acetyl-L-homoserine acetate-lyase (L-homocysteine forming) | O-acetyl-L-homoserine acetate-lyase (L-homocysteine forming) | O-Acetyl-L-homoserine + Thiosulfate + Thioredoxin + H+ <=> L-Homocysteine + Sulfite + Thioredoxin disulfide + Acetate | C01077 + C00320 + C00342 + C00080 <=> C00155 + C00094 + C00343 + C00033 | irev | Forward | c | YALI0C22088g OR YALI0D17402g | 2.5.1.48 |  |  | Cysteine and methionine metabolism | Pyridoxal 5'-phosphate. |  |  |  | Also reacts with H(2)S and methanethiol as replacing agents, producing homocysteine and methionine, respectively.In the absence of thiol, can also catalyze beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.Formerly EC 4.2.99.9. | IKU-IKReaction | n-1-n
R0097 | R02619 | 3-sulfino-L-alanine:2-oxoglutarate aminotransferase | 3-sulfino-L-alanine:2-oxoglutarate aminotransferase | 3-Sulfino-L-alanine + 2-Oxoglutarate <=> 3-Sulfinylpyruvate + L-Glutamate | C00606 + C00026 <=> C05527 + C00025 | irev | Forward | c | YALI0B02178g OR YALI0F29337g | 2.6.1.1 | hypothetical protein | Aspartate aminotransferase | Cysteine and methionine metabolism | Pyridoxal phosphate (By similarity). |  | Unreviewed |  | Also acts on L-tyrosine, L-phenylalanine and L-tryptophan.This activity can be formed from EC 2.6.1.57 by controlled proteolysis. | IKU-IKUReaction | n-1-n
R0098 | R03105 | 3-Mercaptopyruvate:cyanide sulfurtransferase | 3-Mercaptopyruvate:cyanide sulfurtransferase | Mercaptopyruvate + Sulfite <=> Thiosulfate + Pyruvate | C00957 + C00094 <=> C00320 + C00022 | irev | Forward | c | YALI0F23551g | 2.8.1.2 | hypothetical protein |  | Cysteine and methionine metabolism | Zinc. |  | Unreviewed |  | Sulfite, sulfinates, mercaptoethanol and mercaptopyruvate can also act as acceptors. | IKU-IU-noECnoReaction | 1-1-1
R0099 | R03217 | O-Acetyl-L-homoserine succinate-lyase (adding cysteine) | O-Acetyl-L-homoserine succinate-lyase (adding cysteine) | O-Acetyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Acetate | C01077 + C00097 <=> C02291 + C00033 | irev | Forward | c | YALI0C22088g OR YALI0D17402g | 2.5.1.48 |  |  | Cysteine and methionine metabolism | Pyridoxal 5'-phosphate. |  |  |  | Also reacts with H(2)S and methanethiol as replacing agents, producing homocysteine and methionine, respectively.In the absence of thiol, can also catalyze beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.Formerly EC 4.2.99.9. | IKU-IKReaction | n-1-n
R0100 | R03260 | O-Succinyl-L-homoserine succinate-lyase (adding cysteine) | O-Succinyl-L-homoserine succinate-lyase (adding cysteine) | O-Succinyl-L-homoserine + L-Cysteine <=> L-Cystathionine + Succinate | C01118 + C00097 <=> C02291 + C00042 | irev | Forward | c | YALI0C22088g OR YALI0D17402g | 2.5.1.48 |  |  | Cysteine and methionine metabolism | Pyridoxal 5'-phosphate. |  |  |  | Also reacts with H(2)S and methanethiol as replacing agents, producing homocysteine and methionine, respectively.In the absence of thiol, can also catalyze beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.Formerly EC 4.2.99.9. | IKU-IKReaction | n-1-n
[NAME] | R04405 | 5-Methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase | 5-Methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase | 5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine | C04489 + C00155 <=> C04144 + C00073 | irev | Forward | c | YALI0E12683g | 2.1.1.14 | methionine synthase (B12-independent) |  | Cysteine and methionine metabolism | Zinc. |  |  |  | Requires phosphate.The enzyme from Escherichia coli also requires a reducing system.Unlike EC 2.1.1.13 this enzyme does not contain cobalamin. | IKU-IKReaction | 1-1-n
R0102 | R04420 | 5-Methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase | 5-Methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase | S-methyl-5-thio-alpha-D-ribose 1-phosphate <=> S-Methyl-5-thio-D-ribulose 1-phosphate | C04188 <=> C04582 | irev | Forward | c | YALI0A16698g | 5.3.1.23 | methylthioribose-1-phosphate isomerase | Methylthioribose-1-phosphate isomerase | Cysteine and methionine metabolism |  | Amino-acid biosynthesis L-methionine biosynthesis via salvage pathway L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. | Reviewed | Cytoplasm (By similarity). [NAME] (By similarity). | Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) | IKU-IKUReaction | 1-1-1
R0103 | R04859 | O3-acetyl-L-serine:thiosulfate 2-amino-2-carboxyethyltransferase (reducing, L-cysteine-forming); O3-acetyl-L-serine acetate-lyase (thiosulfate-reducing, L-cysteine-forming) | O3-acetyl-L-serine acetate-lyase (thiosulfate-reducing, L-cysteine-forming) | O-Acetyl-L-serine + Thiosulfate + Thioredoxin + H+ <=> L-Cysteine + Sulfite + Thioredoxin disulfide + Acetate | C00979 + C00320 + C00342 + C00080 <=> C00097 + C00094 + C00343 + C00033 | irev | Forward | c | （YALI0D25168g） OR (YALI0E08536g OR YALI0F14047g） | 2.5.1.49 OR 2.5.1.47 | O-acetylhomoserine sulfhydrolase |  | Cysteine and methionine metabolism | Pyridoxal phosphate (By similarity). OR　Pyridoxal 5'-phosphate. |  | Unreviewed OR Unreviewed |  | Also reacts with other thiols and H(2)S, producing homocysteine or thioethers.The name methionine synthase is more commonly applied to EC 2.1.1.13.The enzyme from Saccharomyces cerevisiae also catalyzes the reaction of EC 2.5.1.47, but more slowly.Formerly EC 4.2.99.10. | IKU-differenceReaction　OR IKU-IKUReaction | 1-1-n OR　n-1-n
R0105 | R07364 | 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming) | 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming) | 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one + Oxygen <=> 4-Methylthio-2-oxobutanoic acid + Formate | C15606 + C00007 <=> C01180 + C00058 | irev | Forward | c | YALI0A14498g | 1.13.11.54 | acireductone dioxygenase apoprotein |  | Cysteine and methionine metabolism | [NAME]). |  | Unreviewed |  | If Ni(2+) is bound instead of [NAME]+), the reaction catalyzed by EC 1.13.11.53 occurs instead.The enzyme from Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC 8724 is involved in the methionine salvage pathway. | IKU-IU-noECnoReaction | 1-1-n
R0106 | R07392 | S-Methyl-5-thio-D-ribulose-1-phosphate hydro-lyase | S-Methyl-5-thio-D-ribulose-1-phosphate hydro-lyase | S-Methyl-5-thio-D-ribulose 1-phosphate <=> 2,3-Diketo-5-methylthiopentyl-1-phosphate + H2O | C04582 <=> C15650 + C00001 | irev | Forward | c | YALI0C20427g | 4.2.1.109 | methylthioribulose-1-phosphate dehydratase | Methylthioribulose-1-phosphate dehydratase | Cysteine and methionine metabolism | Binds 1 zinc ion per subunit (By similarity). | Amino-acid biosynthesis L-methionine biosynthesis via salvage pathway L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. | Reviewed | Cytoplasm (By similarity). | This enzyme forms part of the methionine salvage pathway. | IKU-IKUReaction | 1-1-1
R0107 | R07395 | 5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing) | 5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing) | 2,3-Diketo-5-methylthiopentyl-1-phosphate + H2O <=> 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one + Orthophosphate | C15650 + C00001 <=> C15606 + C00009 | irev | Forward | c | YALI0D16797g | 3.1.3.77 | acireductone synthase | Enolase-phosphatase E1 | Cysteine and methionine metabolism | Binds 1 magnesium ion per subunit (By similarity). | Amino-acid biosynthesis L-methionine biosynthesis via salvage pathway L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. | Reviewed | Cytoplasm (By similarity). [NAME] (By similarity). | This bifunctional enzyme first enolizes the substrate to form the intermediate 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate, which is then dephosphorylated to form the acireductone 1,2- dihydroxy-5-(methylthio)pent-1-en-3-one.The acireductone represents a branch point in the methione salvage pathway as it is used in the formation of formate, CO and 3-(methylthio)propanoate by EC 1.13.11.53 and of formate and 4-methylthio-2-oxobutanoate either by a spontaneous reaction under aerobic conditions or by EC 1.13.11.54. | IKU-KUReaction | 1-1-1
R0108 | R04861 | NO NAME | NO NAME | 3-Sulfinylpyruvate + H2O <=> Sulfite + Pyruvate | C05527 + C00001 <=> C00094 + C00022 | irev | Forward | c |  |  |  |  | Cysteine and methionine metabolism |  |  |  |  | spontaneous reaction
R0109 | R02025 | L-methionine:oxidized-thioredoxin S-oxidoreductase | L-methionine:oxidized-thioredoxin S-oxidoreductase | L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine S-oxide + Thioredoxin | C00073 + C00343 + C00001 <=> C02989 + C00342 | irev | Backward | c | YALI0F25201g | 1.8.4.14 |  |  | Cysteine and methionine metabolism
R0110 | R07396 | NO NAME | NO NAME | 4-Methylthio-2-oxobutanoic acid + L-Glutamate <=> L-Methionine + 2-Oxoglutarate | C01180 + C00025 <=> C00073 + C00026 | irev | Forward | c | YALI0E20977g | 2.6.1.5，2.6.1.57 | hypothetical protein |  | Cysteine and methionine metabolism | Pyridoxal 5'-phosphate. |  | Unreviewed |  |  | IKU-differenceReaction | 1-n-n
R0116 | R00261 | L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) | L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) | L-Glutamate <=> 4-Aminobutanoate + CO2 | C00025 <=> C00334 + C00011 | irev | Forward | c | YALI0F08415g | 4.1.1.15 | glutamate decarboxylase |  | Butanoate metabolism | Pyridoxal 5'-phosphate. |  |  |  | The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate. | IKU-IKReaction | 1-1-n
R0117 | R00410 | succinyl-CoA:acetoacetate CoA-transferase | succinyl-CoA:acetoacetate CoA-transferase | Succinyl-CoA + Acetoacetate <=> Succinate + Acetoacetyl-CoA | C00091 + C00164 <=> C00042 + C00332 | r |  | c | [NAME] | 2.8.3.5 | hypothetical protein |  | Butanoate metabolism |  |  | Unreviewed |  | Acetoacetate or, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptor.Malonyl-CoA can act instead of succinyl-CoA. | IKU-IKReaction | 1-1-1
R0118 | R01648 | 4-aminobutanoate:2-oxoglutarate aminotransferase | 4-aminobutanoate:2-oxoglutarate aminotransferase | 4-Aminobutanoate + 2-Oxoglutarate <=> Succinate semialdehyde + L-Glutamate | C00334 + C00026 <=> C00232 + C00025 | r |  | c | YALI0E18238g | 2.6.1.19 | 4-aminobutyrate aminotransferase apoenzyme |  | Butanoate metabolism |  |  | Unreviewed |  | Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate. | IKU-differenceReaction | 1-n-n
R0119 | R01976 | (S)-3-Hydroxybutanoyl-CoA:NADP+ oxidoreductase | (S)-3-Hydroxybutanoyl-CoA:NADP+ oxidoreductase | (S)-3-Hydroxybutanoyl-CoA + NADP+ <=> Acetoacetyl-CoA + NADPH + H+ | C01144 + C00006 <=> C00332 + C00005 + C00080 | r |  | c | YALI0C08811g | 1.1.1.157 | 3-hydroxyacyl-CoA dehydrogenase |  | Butanoate metabolism |  |  | Unreviewed |  |  | IKU-differenceReaction | 1-1-1
R0124 |  | fatty acid synthase (n-C8:0), lumped reaction | fatty acid synthase (n-C8:0), lumped reaction | [NAME] (8) h + (3) malcoa + (6) nadph --> (3) co2 + (4) coa + (2) h2o + (6) nadp + octa |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0125 |  | fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction | fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction | [NAME]9) h + (3) malcoa + (6) nadph --> (3) co2 + (3) coa + (3) h2o + (6) nadp + occoa |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0126 |  | fatty acyl-CoA synthase (n-C10:0CoA) | fatty acyl-CoA synthase (n-C10:0CoA) | (3) h + malcoa + (2) nadph + occoa --> co2 + coa + dcacoa + h2o + (2) nadp |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0127 |  | fatty acid synthase (n-C10:0) | fatty acid synthase (n-C10:0) | (3) h + malcoa + (2) nadph + octa --> co2 + coa + dca + h2o + (2) nadp |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0128 |  | fatty acid synthase (n-C12:0) | fatty acid synthase (n-C12:0) | [NAME]3) h + malcoa + (2) nadph --> co2 + coa + ddca + h2o + (2) nadp |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0129 |  | fatty-acyl-CoA synthase (n-C12:0CoA) | fatty-acyl-CoA synthase (n-C12:0CoA) | dcacoa + (3) h + malcoa + (2) nadph --> co2 + coa + ddcacoa + h2o + (2) nadp |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0130 |  | fatty acid synthase (n-C14:0) | fatty acid synthase (n-C14:0) | [NAME]3) h + malcoa + (2) nadph --> co2 + coa + h2o + (2) [NAME] |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0131 |  | fatty-acyl-CoA synthase (n-C14:0CoA) | fatty-acyl-CoA synthase (n-C14:0CoA) | ddcacoa + (3) h + malcoa + (2) nadph --> co2 + coa + h2o + (2) nadp + tdcoa |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0132 |  | fatty acid synthase (n-C16:0) | fatty acid synthase (n-C16:0) | (3) h + malcoa + (2) [NAME] --> co2 + coa + h2o + hdca + (2) nadp |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0133 |  | fatty-acyl-CoA synthase (n-C16:0CoA) | fatty-acyl-CoA synthase (n-C16:0CoA) | (3) h + malcoa + (2) nadph + tdcoa --> co2 + coa + h2o + (2) nadp + pmtcoa |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0134 |  | fatty acid synthase (n-C18:0) | fatty acid synthase (n-C18:0) | (3) h + hdca + malcoa + (2) nadph --> co2 + coa + h2o + (2) nadp + ocdca |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
[NAME] |  | fatty-acyl-CoA synthase (n-C18:0CoA) | fatty-acyl-CoA synthase (n-C18:0CoA) | (3) h + malcoa + (2) nadph + pmtcoa --> co2 + coa + h2o + (2) nadp + stcoa |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0136 |  | fatty acid synthase (n-C24:0), lumped reaction | fatty acid synthase (n-C24:0), lumped reaction | (9) h + (3) malcoa + (6) nadph + ocdca --> (3) co2 + (3) coa + (3) h2o + (6) [NAME] |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
[NAME] |  | fatty acid synthase (n-C26:0) | fatty acid synthase (n-C26:0) | (3) h + malcoa + (2) nadph + ttc --> co2 + coa + h2o + hexc + (2) nadp |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0138 |  | fatty acid synthase (n-C14:1) | fatty acid synthase (n-C14:1) | [NAME]4) h + malcoa + (3) nadph + o2 --> co2 + coa + (3) h2o + (3) [NAME] |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0139 |  | fatty acid synthase (n-C16:1) | fatty acid synthase (n-C16:1) | (4) h + malcoa + (3) nadph + o2 + ttdca --> co2 + coa + (3) h2o + hdcea + (3) nadp |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0140 |  | fatty acid synthase (n-C18:1) | fatty acid synthase (n-C18:1) | (4) h + hdca + malcoa + (3) nadph + o2 --> co2 + coa + (3) h2o + (3) nadp + ocdcea |  | irev | Forward | c | YALI0A04983g AND YALI0F11935g AND YALI0A06787g |  |  |  | Fatty acid elongation
R0141 |  | fatty-acid--CoA ligase (decanoate) | fatty-acid--CoA ligase (decanoate) | atp + coa + dca <==> amp + dcacoa + ppi |  | r |  | c | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid elongation |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0142 |  | fatty-acid--CoA ligase (dodecanoate) | fatty-acid--CoA ligase (dodecanoate) | atp + coa + ddca <==> amp + ddcacoa + ppi |  | r |  | c | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid elongation |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0143 |  | fatty-acid--CoA ligase (tetradecanoate) | fatty-acid--CoA ligase (tetradecanoate) | atp + coa + ttdca <==> amp + ppi + tdcoa |  | r |  | c | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid elongation |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0144 |  | fatty-acid--CoA ligase (tetradecenoate) | fatty-acid--CoA ligase (tetradecenoate) | atp + coa + ttdcea <==> amp + ppi + tdecoa |  | r |  | c | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid elongation |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0145 |  | fatty-acid--CoA ligase (hexadecanoate) | fatty-acid--CoA ligase (hexadecanoate) | atp + coa + hdca <==> amp + pmtcoa + ppi |  | r |  | c | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid elongation |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0146 |  | fatty-acid--CoA ligase (hexadecenoate) | fatty-acid--CoA ligase (hexadecenoate) | atp + coa + hdcea <==> amp + hdcoa + ppi |  | r |  | c | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid elongation |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0147 |  | fatty-acid--CoA ligase (octadecanoate) | fatty-acid--CoA ligase (octadecanoate) | atp + coa + ocdca <==> amp + ppi + stcoa |  | r |  | c | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid elongation |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0148 |  | fatty-acid--CoA ligase (octadecenoate) | fatty-acid--CoA ligase (octadecenoate) | atp + coa + ocdcea <==> amp + odecoa + ppi |  | r |  | c | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid elongation |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0149 |  | fatty-acid--CoA ligase (octadecynoate) | fatty-acid--CoA ligase (octadecynoate) | atp + coa + ocdcya <==> amp + ocdycacoa + ppi |  | r |  | c | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid elongation |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0150 |  | fatty-acid--CoA ligase (n-C24:0) | fatty-acid--CoA ligase (n-C24:0) | atp + coa + ttc <==> amp + ppi + ttccoa |  | r |  | c | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid elongation |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0151 |  | fatty-acid--CoA ligase (n-C26:0) | fatty-acid--CoA ligase (n-C26:0) | atp + coa + hexc <==> amp + hexccoa + ppi |  | r |  | c | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid elongation |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0152 |  | fatty-acid--CoA ligase (octanoate) | fatty-acid--CoA ligase (octanoate) | atp + coa + octa <==> amp + occoa + ppi |  | r |  | c | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid elongation |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0153 |  | Myristicoyl-CoA desaturase (n-C14:0CoA -> n-C14:1CoA) | Myristicoyl-CoA desaturase (n-C14:0CoA -> n-C14:1CoA) | h + nadph + o2 + tdcoa --> (2) h2o + nadp + tdecoa |  | irev | Forward | c |  |  |  |  | Fatty acid elongation
R0154 |  | Palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA) | Palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA) | h + nadph + o2 + pmtcoa --> (2) h2o + hdcoa + nadp |  | irev | Forward | c | YALI0C05951g | 1.14.19.1 |  |  | Fatty acid elongation
R0155 |  | stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA) | stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA) | h + nadph + o2 + stcoa --> (2) h2o + nadp + odecoa |  | irev | Forward | c | YALI0C05951g | 1.14.19.1 |  |  | Fatty acid elongation
R0156 |  | Oleoyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA) | Oleoyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA) | h + nadph + o2 + odecoa --> (2) h2o + nadp + ocdycacoa |  | irev | Forward | c |  |  |  |  | Fatty acid elongation
R0160 | R01624 | acetyl-CoA:[acyl-carrier-protein] S-acetyltransferase | acetyl-CoA:[acyl-carrier-protein] S-acetyltransferase | Acetyl-CoA + Acyl-carrier protein <=> CoA + Acetyl-[acyl-carrier protein] | C00024 + C00229 <=> C00010 + C03939 | irev | Forward | c | YALI0B19382g AND YALI0B15059g | 2.3.1.86 |  |  | Fatty acid biosynthesis |  |  |  |  | The Saccharomyces cerevisiae enzyme is a multi-functional protein catalyzing the reactions of EC 2.3.1.38, EC 2.3.1.39, EC 2.3.1.41, EC 1.1.1.100, EC 1.1.1.279, EC 4.2.1.61 and EC 1.3.1.9. | IKU-IU-noECnoReaction | n-1-n
R0161 | R01626 | Malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase | Malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase | Malonyl-CoA + Acyl-carrier protein <=> CoA + Malonyl-[acyl-carrier protein] | C00083 + C00229 <=> C00010 + C01209 | r |  | c | YALI0B19382g AND YALI0B15059g | 2.3.1.86 |  |  | Fatty acid biosynthesis |  |  |  |  | The Saccharomyces cerevisiae enzyme is a multi-functional protein catalyzing the reactions of EC 2.3.1.38, EC 2.3.1.39, EC 2.3.1.41, EC 1.1.1.100, EC 1.1.1.279, EC 4.2.1.61 and EC 1.3.1.9. | IKU-IU-noECnoReaction | n-1-n
R0162 | R00742 | Acetyl-CoA:carbon-dioxide ligase (ADP-forming) | Acetyl-CoA:carbon-dioxide ligase (ADP-forming) | l | C00002 + C00024 + C00288 <=> C00008 + C00009 + C00083 | r |  | c | YALI0C11407g | 6.4.1.2 AND 6.3.4.14 |  |  | Fatty acid biosynthesis |  |  | Unreviewed |  |  | IKU-IKReaction OR IKU-IKReaction | 1-n-n OR 1-n-n
[NAME] |  | fatty acyl-ACP synthase (n-C8:0ACP), lumped reaction | fatty acyl-ACP synthase (n-C8:0ACP), lumped reaction | acACP + (9) h + (3) malACP + (6) nadph --> (3) ACP + (3) co2 + (3) h2o + (6) [NAME] |  | irev | Forward | c | YALI0B15059g AND YALI0B19382g AND  YALI0F30679g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0164 |  | fatty-acyl-ACP synthase (n-C10:0ACP) | fatty-acyl-ACP synthase (n-C10:0ACP) | (3) h + malACP + (2) nadph + ocACP --> ACP + co2 + dcaACP + h2o + (2) nadp |  | irev | Forward | c | YALI0B15059g AND YALI0B19382g AND  YALI0F30679g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0165 |  | fatty-acyl-ACP synthase (n-C12:0ACP) | fatty-acyl-ACP synthase (n-C12:0ACP) | [NAME]3) h + malACP + (2) nadph --> ACP + co2 + ddcaACP + h2o + (2) nadp |  | irev | Forward | c | YALI0B15059g AND YALI0B19382g AND  YALI0F30679g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0166 |  | fatty-acyl-ACP synthase (n-C14:0ACP) | fatty-acyl-ACP synthase (n-C14:0ACP) | ddcaACP + (3) h + malACP + (2) nadph --> ACP + co2 + h2o + myrsACP + (2) nadp |  | irev | Forward | c | YALI0B15059g AND YALI0B19382g AND  YALI0F30679g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0167 |  | fatty-acyl-ACP synthase (n-C14:1ACP) | fatty-acyl-ACP synthase (n-C14:1ACP) | ddcaACP + (4) h + malACP + (3) nadph + o2 --> ACP + co2 + (3) h2o + (3) [NAME] |  | irev | Forward | c | YALI0B15059g AND YALI0B19382g AND  YALI0F30679g | 2.3.1.86 |  |  | Fatty acid biosynthesis
[NAME] |  | fatty-acyl-ACP synthase (n-C16:1ACP) | fatty-acyl-ACP synthase (n-C16:1ACP) | (4) h + malACP + myrsACP + (3) nadph + o2 --> ACP + co2 + (3) h2o + hdeACP + (3) nadp |  | irev | Forward | c | YALI0B15059g AND YALI0B19382g AND  YALI0F30679g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0169 |  | fatty-acyl-ACP synthase (n-C16:0ACP) | fatty-acyl-ACP synthase (n-C16:0ACP) | (3) h + malACP + myrsACP + (2) nadph --> ACP + co2 + h2o + (2) nadp + palmACP |  | irev | Forward | c | YALI0B15059g AND YALI0B19382g AND  YALI0F30679g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0170 |  | fatty-acyl-ACP synthase (n-C18:2ACP) | fatty-acyl-ACP synthase (n-C18:2ACP) | (5) h + malACP + (4) [NAME] (2) o2 + palmACP --> ACP + co2 + (5) h2o + (4) nadp + ocdcyaACP |  | irev | Forward | c | YALI0B15059g AND YALI0B19382g AND  YALI0F30679g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0171 |  | fatty-acyl-ACP synthase (n-C18:1ACP) | fatty-acyl-ACP synthase (n-C18:1ACP) | (4) h + malACP + (3) nadph + o2 + palmACP --> ACP + co2 + (3) h2o + (3) [NAME] |  | irev | Forward | c | YALI0B15059g AND YALI0B19382g AND  YALI0F30679g | 2.3.1.86 |  |  | Fatty acid biosynthesis
[NAME] |  | fatty-acyl-ACP synthase (n-C18:0ACP) | fatty-acyl-ACP synthase (n-C18:0ACP) | (3) h + malACP + (2) [NAME] --> ACP + co2 + h2o + (2) [NAME] |  | irev | Forward | c | YALI0B15059g AND YALI0B19382g AND  YALI0F30679g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0173 |  | fatty-acyl-ACP hydrolase | fatty-acyl-ACP hydrolase | ddcaACP + h2o <=> ACP + ddca + h |  | r |  | c | YALI0B15059g AND YALI0B19382g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0174 |  | fatty-acyl-ACP hydrolase | fatty-acyl-ACP hydrolase | h2o + myrsACP <=> ACP + h + ttdca |  | r |  | c | YALI0B15059g AND YALI0B19382g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0175 |  | fatty-acyl-ACP hydrolase | fatty-acyl-ACP hydrolase | h2o + tdeACP <=> ACP + h + ttdcea |  | r |  | c | YALI0B15059g AND YALI0B19382g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0176 |  | fatty-acyl-ACP hydrolase | fatty-acyl-ACP hydrolase | h2o + palmACP <=> ACP + h + hdca |  | r |  | c | YALI0B15059g AND YALI0B19382g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0177 |  | fatty-acyl-ACP hydrolase | fatty-acyl-ACP hydrolase | h2o + hdeACP <=> ACP + h + hdcea |  | r |  | c | YALI0B15059g AND YALI0B19382g | 2.3.1.86 |  |  | Fatty acid biosynthesis
[NAME] |  | fatty-acyl-ACP hydrolase | fatty-acyl-ACP hydrolase | h2o + ocdcaACP <=> ACP + h + ocdca |  | r |  | c | YALI0B15059g AND YALI0B19382g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0179 |  | fatty-acyl-ACP hydrolase | fatty-acyl-ACP hydrolase | h2o + octeACP <=> ACP + h + ocdcea |  | r |  | c | YALI0B15059g AND YALI0B19382g | 2.3.1.86 |  |  | Fatty acid biosynthesis
[NAME] |  | fatty-acyl-ACP hydrolase | fatty-acyl-ACP hydrolase | h2o + ocdcyaACP <=> ACP + h + ocdcya |  | r |  | c | YALI0B15059g AND YALI0B19382g | 2.3.1.86 |  |  | Fatty acid biosynthesis
R0181 | R00289 | UTP:alpha-D-glucose-1-phosphate uridylyltransferase | UTP:alpha-D-glucose-1-phosphate uridylyltransferase | UTP + D-Glucose 1-phosphate <=> Diphosphate + UDP-glucose | C00075 + C00103 <=> C00013 + C00029 | r |  | c | YALI0A02310g | 2.7.7.9 | hypothetical protein |  | Galactose metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0182 | R00291 | UDP-glucose 4-epimerase | UDP-glucose 4-epimerase | UDP-glucose <=> UDP-D-galactose | C00029 <=> C00052 | r |  | c | YALI0E26829g | 5.1.3.2 | UDP-galactose 4-epimerase |  | Galactose metabolism |  |  | Unreviewed |  |  | IKU-differenceReaction | 1-n-n
R0183 | R00955 | UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase | UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase | UDP-glucose + alpha-D-Galactose 1-phosphate <=> D-Glucose 1-phosphate + UDP-D-galactose | C00029 + C00446 <=> C00103 + C00052 | r |  | c | YALI0F23947g | 2.7.7.12 | UDP-glucose-hexose-1-phosphate uridylyltransferase | Galactose-1-phosphate uridylyltransferase | Galactose metabolism | Binds 1 zinc ion per subunit (By similarity). | Carbohydrate metabolism galactose metabolism. | Unreviewed |  |  | IKU-KUReaction | 1-1-1
R0184 | R01092 | ATP:D-galactose 1-phosphotransferase | ATP:D-galactose 1-phosphotransferase | ATP + D-Galactose <=> ADP + alpha-D-Galactose 1-phosphate | C00002 + C00124 <=> C00008 + C00446 | irev | Forward | c | YALI0C13090g | 2.7.1.6 | putative GAL1 galactokinase |  | Galactose metabolism |  |  |  |  | D-galactosamine can also act as acceptor. | IKU-IKReaction | 1-1-1
R0191 |  | acyl-CoA oxidase (hexacanoyl-CoA) | acyl-CoA oxidase (hexacanoyl-CoA) | hexccoa + o2 --> h2o2 + hxc2coa |  | irev | Forward | m | YALI0C23859g OR YALI0D24750g OR YALI0F10857g | 1.3.3.6 |  |  | Fatty acid metabolism | FAD |  |  |  | Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18). | IKU-IKUReaction | n-1-n
R0192 |  | 3-hydroxyacyl-CoA dehydratase (3-hydroxyhexacosyl-CoA) | 3-hydroxyacyl-CoA dehydratase (3-hydroxyhexacosyl-CoA) | h2o + hxc2coa <==> 3hxccoa |  | r |  | m | YALI0B10406g | 4.2.1.17 | short chain enoyl-CoA hydratase |  | Fatty acid metabolism |  |  |  |  | Acts in the reverse direction.With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74). | IKU-IKReaction | 1-1-n
R0193 |  | 3-hydroxyacyl-CoA dehydrogenase (3-oxohexacosyl-CoA) | 3-hydroxyacyl-CoA dehydrogenase (3-oxohexacosyl-CoA) | 3hxccoa + nad <==> 3ohxccoa + h + nadh |  | r |  | m |  |  |  |  | Fatty acid metabolism
[NAME] |  | acetyl-CoA acyltransferase (tetracosanoyl-CoA) | acetyl-CoA acyltransferase (tetracosanoyl-CoA) | 3ohxccoa + coa --> accoa + ttccoa |  | irev | Forward | m | YALI0E18568g | 2.3.1.16 | YlPOT1 | 3-ketoacyl-CoA thiolase, peroxisomal | Fatty acid metabolism |  | Lipid metabolism fatty acid metabolism. | Reviewed | Peroxisome. |  | IKU-IKUReaction | 1-1-n
R0195 |  | fatty acid oxidation (tetradecansoyl-CoA) | fatty acid oxidation (tetradecansoyl-CoA) | (3) coa + (3) h2o + (3) nad + (3) o2 + ttccoa --> (3) accoa + (3) h + (3) h2o2 + (3) nadh + stcoa |  | irev | Forward | m | ( YALI0C23859g OR YALI0D24750g OR YALI0F10857g ) AND ( YALI0B10406g ) AND ( YALI0E18568g ) |  |  |  | Fatty acid metabolism
[NAME] |  | acyl-CoA oxidase (octadecanoyl-CoA) | acyl-CoA oxidase (octadecanoyl-CoA) | o2 + stcoa --> h2o2 + od2coa |  | irev | Forward | m | YALI0C23859g OR YALI0D24750g OR YALI0F10857g | 1.3.3.6 |  |  | Fatty acid metabolism | FAD |  |  |  | Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18). | IKU-IKUReaction | n-1-n
R0197 |  | 3-hydroxyacyl-CoA dehydratase (3-hydroxyoctadecanoyl-CoA) | 3-hydroxyacyl-CoA dehydratase (3-hydroxyoctadecanoyl-CoA) | 3hodcoa <==> h2o + od2coa |  | r |  | m | YALI0B10406g | 4.2.1.17 | short chain enoyl-CoA hydratase |  | Fatty acid metabolism |  |  |  |  | Acts in the reverse direction.With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74). | IKU-IKReaction | 1-1-n
R0198 |  | 3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA) | 3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA) | 3ohodcoa + h + nadh <==> 3hodcoa + nad |  | r |  | m |  |  |  |  | Fatty acid metabolism
R0199 |  | acetyl-CoA acyltransferase (hexadecanoyl-CoA) | acetyl-CoA acyltransferase (hexadecanoyl-CoA) | 3ohodcoa + coa --> accoa + pmtcoa |  | irev | Forward | m | YALI0E18568g | 2.3.1.16 | YlPOT1 | 3-ketoacyl-CoA thiolase, peroxisomal | Fatty acid metabolism |  | Lipid metabolism fatty acid metabolism. | Reviewed | Peroxisome. |  | IKU-IKUReaction | 1-1-n
R0200 |  | acyl-CoA oxidase (hexadecanoyl-CoA) | acyl-CoA oxidase (hexadecanoyl-CoA) | o2 + pmtcoa --> h2o2 + hdd2coa |  | irev | Forward | m | YALI0C23859g OR YALI0D24750g OR YALI0F10857g | 1.3.3.6 |  |  | Fatty acid metabolism | FAD |  |  |  | Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18). | IKU-IKUReaction | n-1-n
R0201 | R04738 | (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase | (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase | (S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O | C05258 <=> C05272 + C00001 | r |  | m | YALI0B10406g | 4.2.1.17 | short chain enoyl-CoA hydratase |  | Fatty acid metabolism |  |  |  |  | Acts in the reverse direction.With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74). | IKU-IKReaction | 1-1-n
R0202 |  | 3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA) | 3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA) | 3ohdcoa + h + nadh <==> 3hhdcoa + nad |  | r |  | m |  |  |  |  | Fatty acid metabolism
R0203 | R03991 | myristoyl-CoA:acetylCoA C-myristoyltransferase | myristoyl-CoA:acetylCoA C-myristoyltransferase | Tetradecanoyl-CoA + Acetyl-CoA <=> CoA + 3-Oxopalmitoyl-CoA | C02593 + C00024 <=> C00010 + C05259 | irev | Backward | m | YALI0E18568g | 2.3.1.16 | YlPOT1 | 3-ketoacyl-CoA thiolase, peroxisomal | Fatty acid metabolism |  | Lipid metabolism fatty acid metabolism. | Reviewed | Peroxisome. |  | IKU-IKUReaction | 1-1-n
R0204 |  | acyl-CpA oxidase (tetradecanoyl-CoA) | acyl-CpA oxidase (tetradecanoyl-CoA) | o2 + tdcoa --> h2o2 + td2coa |  | irev | Forward | m | YALI0C23859g OR YALI0D24750g OR YALI0F10857g | 1.3.3.6 |  |  | Fatty acid metabolism | FAD |  |  |  | Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18). | IKU-IKUReaction | n-1-n
R0205 | R04740 | (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase | (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase | (S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O | C05260 <=> C05273 + C00001 | r |  | m | YALI0B10406g | 4.2.1.17 | short chain enoyl-CoA hydratase |  | Fatty acid metabolism |  |  |  |  | Acts in the reverse direction.With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74). | IKU-IKReaction | 1-1-n
R0206 |  | 3-Hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA) | 3-Hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA) | 3otdcoa + h + nadh <==> 3htdcoa + nad |  | r |  | m |  |  |  |  | Fatty acid metabolism
R0207 | R03858 | Lauroyl-CoA:acetyl-CoA C-acyltransferase | Lauroyl-CoA:acetyl-CoA C-acyltransferase | Lauroyl-CoA + Acetyl-CoA <=> CoA + 3-Oxotetradecanoyl-CoA | C01832 + C00024 <=> C00010 + C05261 | irev | Backward | m | YALI0E18568g | 2.3.1.16 | YlPOT1 | 3-ketoacyl-CoA thiolase, peroxisomal | Fatty acid metabolism |  | Lipid metabolism fatty acid metabolism. | Reviewed | Peroxisome. |  | IKU-IKUReaction | 1-1-n
R0208 |  | acyl-CoA oxidase (dodecanoyl-CoA) | acyl-CoA oxidase (dodecanoyl-CoA) | [NAME] --> dd2coa [NAME] |  | irev | Forward | m | YALI0C23859g OR YALI0D24750g OR YALI0F10857g | 1.3.3.6 |  |  | Fatty acid metabolism | FAD |  |  |  | Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18). | IKU-IKUReaction | n-1-n
R0209 | R04170 | (S)-3-Hydroxydodecanoyl-CoA hydro-lyase | (S)-3-Hydroxydodecanoyl-CoA hydro-lyase | (S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O | C05262 <=> C03221 + C00001 | r |  | m | YALI0B10406g | 4.2.1.17 | short chain enoyl-CoA hydratase |  | Fatty acid metabolism |  |  |  |  | Acts in the reverse direction.With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74). | IKU-IKReaction | 1-1-n
R0210 |  | 3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA) | 3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA) | 3oddcoa + h + nadh <==> 3hddcoa + nad |  | r |  | m |  |  |  |  | Fatty acid metabolism
R0211 | [NAME] | Decanoyl-CoA:acetyl-CoA C-acyltransferase | Decanoyl-CoA:acetyl-CoA C-acyltransferase | Decanoyl-CoA + Acetyl-CoA <=> CoA + 3-Oxododecanoyl-CoA | C05274 + C00024 <=> C00010 + C05263 | irev | Backward | m | YALI0E18568g | 2.3.1.16 | YlPOT1 | 3-ketoacyl-CoA thiolase, peroxisomal | Fatty acid metabolism |  | Lipid metabolism fatty acid metabolism. | Reviewed | Peroxisome. |  | IKU-IKUReaction | 1-1-n
R0212 |  | acyl-CoA oxidase (decanoyl-CoA) | acyl-CoA oxidase (decanoyl-CoA) | dcacoa + o2 --> dc2coa + h2o2 |  | irev | Forward | m | YALI0C23859g OR YALI0D24750g OR YALI0F10857g | 1.3.3.6 |  |  | Fatty acid metabolism | FAD |  |  |  | Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18). | IKU-IKUReaction | n-1-n
R0213 | R04744 | (S)-Hydroxydecanoyl-CoA hydro-lyase | (S)-Hydroxydecanoyl-CoA hydro-lyase | (S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O | C05264 <=> C05275 + C00001 | r |  | m | YALI0B10406g | 4.2.1.17 | short chain enoyl-CoA hydratase |  | Fatty acid metabolism |  |  |  |  | Acts in the reverse direction.With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74). | IKU-IKReaction | 1-1-n
R0214 |  | 3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA) | 3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA) | 3odcoa + h + nadh <==> 3hdcoa + nad |  | r |  | m |  |  |  |  | Fatty acid metabolism
R0215 | R03778 | Octanoyl-CoA:acetyl-CoA C-acyltransferase | Octanoyl-CoA:acetyl-CoA C-acyltransferase | Octanoyl-CoA + Acetyl-CoA <=> CoA + 3-Oxodecanoyl-CoA | C01944 + C00024 <=> C00010 + C05265 | irev | Backward | m | YALI0E18568g | 2.3.1.16 | YlPOT1 | 3-ketoacyl-CoA thiolase, peroxisomal | Fatty acid metabolism |  | Lipid metabolism fatty acid metabolism. | Reviewed | Peroxisome. |  | IKU-IKUReaction | 1-1-n
R0216 |  | fatty acid oxidation (octanoyl-CoA) | fatty acid oxidation (octanoyl-CoA) | (3) coa + (3) h2o + (3) nad + (3) o2 + occoa --> (4) accoa + (3) h + (3) h2o2 + (3) nadh |  | irev | Forward | m | ( YALI0C23859g OR YALI0D24750g OR YALI0F10857g ) AND ( YALI0B10406g ) AND ( YALI0E18568g ) |  |  |  | Fatty acid metabolism
R0217 |  | fatty acid oxidation | fatty acid oxidation | (6) coa + (6) h2o + (6) nad + nadph + (6) o2 + tdecoa --> (7) accoa + (5) h + (6) h2o2 + (6) nadh + nadp |  | irev | Forward | m | ( YALI0C23859g OR YALI0D24750g OR YALI0F10857g ) AND ( YALI0B10406g ) AND ( YALI0E18568g ) |  |  |  | Fatty acid metabolism
R0218 |  | Fatty acid oxidation | Fatty acid oxidation | (6) coa + (6) h2o + (6) nad + (5) o2 + tdecoa --> (7) accoa + (6) h + (5) h2o2 + (6) nadh |  | irev | Forward | m | ( YALI0C23859g OR YALI0D24750g OR YALI0F10857g ) AND ( YALI0B10406g ) AND ( YALI0E18568g ) |  |  |  | Fatty acid metabolism
R0219 |  | Fatty acid oxidation | Fatty acid oxidation | (7) coa + (7) h2o + hdcoa + (7) nad + nadph + (7) o2 --> (8) accoa + (6) h + (7) h2o2 + (7) nadh + nadp |  | irev | Forward | m | ( YALI0C23859g OR YALI0D24750g OR YALI0F10857g ) AND ( YALI0B10406g ) AND ( YALI0E18568g ) |  |  |  | Fatty acid metabolism
R0220 |  | Fatty acid oxidation | Fatty acid oxidation | (7) coa + (7) h2o + hdcoa + (7) nad + (6) o2 --> (8) accoa + (7) h + (6) h2o2 + (7) nadh |  | irev | Forward | m | ( YALI0C23859g OR YALI0D24750g OR YALI0F10857g ) AND ( YALI0B10406g ) AND ( YALI0E18568g ) |  |  |  | Fatty acid metabolism
R0221 |  | Fatty acid oxidation | Fatty acid oxidation | (8) coa + (8) h2o + (8) nad + nadph + (8) o2 + odecoa --> (9) accoa + (7) h + (8) h2o2 + (8) nadh + nadp |  | irev | Forward | m | ( YALI0C23859g OR YALI0D24750g OR YALI0F10857g ) AND ( YALI0B10406g ) AND ( YALI0E18568g ) |  |  |  | Fatty acid metabolism
R0222 |  | Fatty acid oxidation | Fatty acid oxidation | (8) coa + (8) h2o + (8) nad + (7) o2 + odecoa --> (9) accoa + (8) h + (7) h2o2 + (8) nadh |  | irev | Forward | m | ( YALI0C23859g OR YALI0D24750g OR YALI0F10857g ) AND ( YALI0B10406g ) AND ( YALI0E18568g ) |  |  |  | Fatty acid metabolism
R0223 |  | Fatty acid oxidation | Fatty acid oxidation | (8) coa + (8) h2o + (8) nad + (2) [NAME] (8) o2 + ocdycacoa --> (9) accoa + (6) h + (8) h2o2 + (8) nadh + (2) nadp |  | irev | Forward | m | ( YALI0C23859g OR YALI0D24750g OR YALI0F10857g ) AND ( YALI0B10406g ) AND ( YALI0E18568g ) |  |  |  | Fatty acid metabolism
R0224 |  | Fatty acid oxidation | Fatty acid oxidation | (8) coa + (8) h2o + (8) nad + nadph + (7) o2 + ocdycacoa --> (9) accoa + (7) h + (7) h2o2 + (8) nadh + nadp |  | irev | Forward | m | ( YALI0C23859g OR YALI0D24750g OR YALI0F10857g ) AND ( YALI0B10406g ) AND ( YALI0E18568g ) |  |  |  | Fatty acid metabolism
R0225 |  | Fatty acid oxidation | Fatty acid oxidation | (8) coa + (8) h2o + (8) nad + (6) o2 + ocdycacoa --> (9) accoa + (8) h + (6) h2o2 + (8) nadh |  | irev | Forward | m | ( YALI0C23859g OR YALI0D24750g OR YALI0F10857g ) AND ( YALI0B10406g ) AND ( YALI0E18568g ) |  |  |  | Fatty acid metabolism
R0226 |  | acyl-CoA thioesterase | acyl-CoA thioesterase | dcacoa + h2o --> coa + dca + h |  | irev | Forward | m | YALI0F14729g | 3.1.2.2 |  |  | Fatty acid metabolism
[NAME] |  | acyl-CoA thioesterase | acyl-CoA thioesterase | ddcacoa + h2o --> coa + ddca + h |  | irev | Forward | m | YALI0F14729g | 3.1.2.2 |  |  | Fatty acid metabolism
R0228 |  | acyl-CoA thioesterase | acyl-CoA thioesterase | h2o + ttccoa --> coa + h + ttc |  | irev | Forward | m | YALI0F14729g | 3.1.2.2 |  |  | Fatty acid metabolism
R0229 |  | acyl-CoA thioesterase | acyl-CoA thioesterase | h2o + pmtcoa --> coa + h + hdca |  | irev | Forward | m | YALI0F14729g | 3.1.2.2 |  |  | Fatty acid metabolism
R0230 |  | acyl-CoA thioesterase | acyl-CoA thioesterase | h2o + tdcoa --> coa + h + ttdca |  | irev | Forward | m | YALI0F14729g | 3.1.2.2 |  |  | Fatty acid metabolism
[NAME] |  | acyl-CoA thioesterase | acyl-CoA thioesterase | h2o + stcoa --> coa + h + ocdca |  | irev | Forward | m | YALI0F14729g | 3.1.2.2 |  |  | Fatty acid metabolism
R0232 |  | acyl-CoA thioesterase | acyl-CoA thioesterase | h2o + occoa --> coa + h + octa |  | irev | Forward | m | YALI0F14729g | 3.1.2.2 |  |  | Fatty acid metabolism
R0233 |  | fatty-acid--CoA ligase (decanoate) | fatty-acid--CoA ligase (decanoate) | atp + coa + dca <==> amp + dcacoa + ppi |  | r |  | m | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid metabolism |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0234 |  | fatty-acid--CoA ligase (dodecanoate) | fatty-acid--CoA ligase (dodecanoate) | atp + coa + ddca <==> amp + ddcacoa + ppi |  | r |  | m | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid metabolism |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0235 |  | fatty-acid--CoA ligase (tetradecanoate) | fatty-acid--CoA ligase (tetradecanoate) | atp + coa + ttdca <==> amp + ppi + tdcoa |  | r |  | m | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid metabolism |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0236 |  | fatty-acid--CoA ligase (tetradecenoate) | fatty-acid--CoA ligase (tetradecenoate) | atp + coa + ttdcea <==> amp + ppi + tdecoa |  | r |  | m | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid metabolism |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0237 |  | fatty-acid--CoA ligase (hexadecanoate) | fatty-acid--CoA ligase (hexadecanoate) | atp + coa + hdca <==> amp + pmtcoa + ppi |  | r |  | m | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid metabolism |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0238 |  | fatty-acid--CoA ligase (hexadecenoate) | fatty-acid--CoA ligase (hexadecenoate) | atp + coa + hdcea <==> amp + hdcoa + ppi |  | r |  | m | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid metabolism |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0239 |  | fatty-acid--CoA ligase (octadecanoate) | fatty-acid--CoA ligase (octadecanoate) | atp + coa + ocdca <==> amp + ppi + stcoa |  | r |  | m | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid metabolism |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0240 |  | fatty-acid--CoA ligase (octadecenoate) | fatty-acid--CoA ligase (octadecenoate) | atp + coa + ocdcea <==> amp + odecoa + ppi |  | r |  | m | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid metabolism |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0241 |  | fatty-acid--CoA ligase (octadecynoate) | fatty-acid--CoA ligase (octadecynoate) | atp + coa + ocdcya <==> amp + ocdycacoa + ppi |  | r |  | m | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid metabolism |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0242 |  | fatty-acid--CoA ligase (n-C24:0) | fatty-acid--CoA ligase (n-C24:0) | atp + coa + ttc <==> amp + ppi + ttccoa |  | r |  | m | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid metabolism |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0243 |  | fatty-acid--CoA ligase (n-C26:0) | fatty-acid--CoA ligase (n-C26:0) | atp + coa + hexc <==> amp + hexccoa + ppi |  | r |  | m | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid metabolism |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0244 |  | fatty-acid--CoA ligase (octanoate) | fatty-acid--CoA ligase (octanoate) | atp + coa + octa <==> amp + occoa + ppi |  | r |  | m | YALI0D17864g | 6.2.1.3 | hypothetical protein |  | Fatty acid metabolism |  |  |  |  | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24). | IKU-IKReaction | 1-1-1
R0245 | R02396 | Acetyl-CoA:carnitine O-acetyltransferase | Acetyl-CoA:carnitine O-acetyltransferase | Acetyl-CoA + Carnitine <=> CoA + O-Acetylcarnitine | C00024 + C00487 <=> C00010 + C02571 | r |  | c | YALI0B10340g OR YALI0F21197g | 2.3.1.7 |  |  | Fatty acid metabolism
R0246 | R02396 | Acetyl-CoA:carnitine O-acetyltransferase | Acetyl-CoA:carnitine O-acetyltransferase | Acetyl-CoA + Carnitine <=> CoA + O-Acetylcarnitine | C00024 + C00487 <=> C00010 + C02571 | r |  | m | YALI0B10340g OR YALI0F21197g | 2.3.1.7 |  |  | Fatty acid metabolism
R0247 | [NAME] | 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase | 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase | Tetrahydrofolate + NADP+ <=> Dihydrofolate + NADPH + H+ | C00101 + C00006 <=> C00415 + C00005 + C00080 | r |  | c | YALI0C12771g | 1.5.1.3 | hypothetical protein |  | Folate biosynthesis |  |  |  |  | The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate.Formerly EC 1.5.1.4. | IKU-IKReaction | 1-1-n
R0248 | [NAME] | 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase | 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase | 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 4-Aminobenzoate <=> Dihydropteroate + H2O | C01300 + C00568 <=> C00921 + C00001 | irev | Forward | m | YALI0A02541g | 2.5.1.15 | hypothetical protein |  | Folate biosynthesis |  |  | Unreviewed |  |  | IKU-differenceReaction | 1-n-n
R0249 | R03067 | 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase | 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase | 2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine + 4-Aminobenzoate <=> Diphosphate + Dihydropteroate | C04807 + C00568 <=> C00013 + C00921 | irev | Forward | m | YALI0A02541g | 2.5.1.15 | hypothetical protein |  | Folate biosynthesis |  |  | Unreviewed |  |  | IKU-differenceReaction | 1-n-n
R0250 | R01716 | chorismate:L-glutamine aminotransferase | chorismate:L-glutamine aminotransferase | Chorismate + L-Glutamine <=> 4-Amino-4-deoxychorismate + L-Glutamate | C00251 + C00064 <=> C11355 + C00025 | irev | Forward | c | YALI0A05379g | 2.6.1.85 | hypothetical protein |  | Folate biosynthesis | Magnesium. |  | Unreviewed |  | Composed of two subunits, PabA and PabB.In the absence of PabA and glutamine, PabB converts ammonia and chorismate into 4-amino-4-deoxychorismate.PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB.Coupled with EC 4.1.3.38, to form 4-aminobenzoate.Formerly EC 6.3.5.8. | IKU-differenceReaction | 1-1-1
[NAME] | R03503 | ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-pyrophosphotransferase | ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-pyrophosphotransferase | ATP + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine <=> AMP + 2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine | C00002 + C01300 <=> C00020 + C04807 | irev | Forward | m | YALI0A02541g | 2.7.6.3 | hypothetical protein |  | Folate biosynthesis |  |  | Unreviewed |  |  | IKU-differenceReaction | 1-n-n
R0252 | R04620 | 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) | 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) | 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate + 3 H2O <=> 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine + 3 Orthophosphate | C04895 + 3 C00001 <=> C04874 + 3 C00009 | irev | Forward | c | YALI0F16709g | 3.1.3.1 | hypothetical protein | Alkaline phosphatase | Folate biosynthesis | Magnesium; Zinc. |  | Unreviewed |  | Active at a high pH optimum.Wide specificity.Also catalyzes transphosphorylations.Some enzymes hydrolase diphosphate (cf. EC 3.6.1.1). | IKU-IKUReaction | 1-1-1
R0257 | R03504 | 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase | 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase | 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine <=> [NAME] + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine | C04874 <=> C00266 + C01300 | irev | Forward | m | YALI0A02541g | 4.1.2.25 | hypothetical protein |  | Folate biosynthesis |  |  | Unreviewed |  |  | IKU-differenceReaction | 1-n-n
R0258 | R00942 | Tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) | Tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) | ATP + Tetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + Tetrahydrofolyl-[Glu](2) | C00002 + C00101 + C00025 <=> C00008 + C00009 + C09332 | r |  | c | YALI0A10032g OR YALI0E24497g | 6.3.2.17 |  |  | Folate biosynthesis |  |  |  |  | In some bacteria, a single protein catalyzes both this activity and that of EC 6.3.2.12, the combined activity of which leads to the formation of the coenzyme polyglutamated tetrahydropteroate (H(4)PteGlu(n)), i.e. various tetrahydrofolates (H(4)folate).In contrast, the activities are located on separate proteins in most eukaryotes studied to date.In Arabidopsis thaliana, this enzyme is present as distinct isoforms in the mitochondria, the cytosol and the chloroplast.Each isoform is encoded by a separate gene, a situation that is unique among eukaryotes.As the affinity of folate-dependent enzymes increases markedly with the number of glutamic residues, the tetrahydropteroyl polyglutamates are the preferred coenzymes of C(1) metabolism.The enzymes from different sources (particularly eukaryotes versus prokaryotes) have different substrate specificities with regard to one-carbon substituents and the number of glutamate residues present on the tetrahydrofolates. | IKU-IKReaction | n-1-n
R0259 | R02237 | 7,8-dihydropteroate:L-glutamate ligase (ADP-forming) | 7,8-dihydropteroate:L-glutamate ligase (ADP-forming) | ATP + Dihydropteroate + L-Glutamate <=> ADP + Orthophosphate + Dihydrofolate | C00002 + C00921 + C00025 <=> C00008 + C00009 + C00415 | irev | Forward | c | YALI0A10032g OR YALI0E24497g | 6.3.2.17 |  |  | Folate biosynthesis |  |  |  |  | In some bacteria, a single protein catalyzes both this activity and that of EC 6.3.2.12, the combined activity of which leads to the formation of the coenzyme polyglutamated tetrahydropteroate (H(4)PteGlu(n)), i.e. various tetrahydrofolates (H(4)folate).In contrast, the activities are located on separate proteins in most eukaryotes studied to date.In Arabidopsis thaliana, this enzyme is present as distinct isoforms in the mitochondria, the cytosol and the chloroplast.Each isoform is encoded by a separate gene, a situation that is unique among eukaryotes.As the affinity of folate-dependent enzymes increases markedly with the number of glutamic residues, the tetrahydropteroyl polyglutamates are the preferred coenzymes of C(1) metabolism.The enzymes from different sources (particularly eukaryotes versus prokaryotes) have different substrate specificities with regard to one-carbon substituents and the number of glutamate residues present on the tetrahydrofolates. | IKU-IKReaction | n-1-n
R0260 |  | D-Glucitol:NAD+ 2-oxidoreductase | D-Glucitol:NAD+ 2-oxidoreductase | D-Sorbitol + NAD+ <=> beta-D-Fructose + NADH + H+ | C00794 + C00003 <=> C02336 + C00004 + C00080 | r |  | c | YALI0E12463g | 1.1.1.14 | D-xylulose reductase |  | Fructose and mannose metabolism | Zinc (By similarity). |  | Unreviewed |  | This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals.It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol.Enzymes from different organisms or tissues display different substrate specificity.The enzyme is specific to NAD(+) and can not use NADP(+). | IKU-differenceReaction | 1-1-1
R0261 | R00885 | GTP:alpha-D-mannose-1-phosphate guanylyltransferase | GTP:alpha-D-mannose-1-phosphate guanylyltransferase | GTP + alpha-D-mannose 1-phosphate <=> Diphosphate + GDP-mannose | C00044 + C00636 <=> C00013 + C00096 | irev | Forward | c | YALI0C06490g OR YALI0E15125g | 2.7.7.13 | mannose-1-phosphate guanylyltransferase | Mannose-1-phosphate guanyltransferase | Fructose and mannose metabolism |  | Nucleotide-sugar biosynthesis GDP-alpha-D-mannose biosynthesis GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1. | Reviewed | Cytoplasm (By similarity). | The bacterial enzyme can also use ITP and dGTP as donors. | IKU-IKUReaction | n-1-1
R0262 | R01326 | ATP:D-mannose 6-phosphotransferase | ATP:D-mannose 6-phosphotransferase | ATP + D-Mannose <=> ADP + D-Mannose 6-phosphate | C00002 + C00159 <=> C00008 + C00275 | irev | Forward | c | YALI0B22308g OR [NAME] YALI0E20207g | 2.7.1.1 |  |  | Fructose and mannose metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0263 | R01818 | D-Mannose 6-phosphate 1,6-phosphomutase | D-Mannose 6-phosphate 1,6-phosphomutase | D-Mannose 6-phosphate <=> D-Mannose 1-phosphate | C00275 <=> C00636 | r |  | c | YALI0D13112g | 5.4.2.8 | hypothetical protein |  | Fructose and mannose metabolism |  |  |  |  | Alpha-D-mannose 1,6-bisphosphate or alpha-D-glucose 1,6-bisphosphate can act as cofactor.Formerly EC 2.7.5.7. | IKU-IKReaction | 1-1-1
R0264 | R01819 | D-mannose-6-phosphate aldose-ketose-isomerase | D-mannose-6-phosphate aldose-ketose-isomerase | D-Mannose 6-phosphate <=> beta-D-Fructose 6-phosphate | C00275 <=> C05345 | r |  | c | YALI0B18348g | 5.3.1.8 | mannose-6-phosphate isomerase, type 1 | Mannose-6-phosphate isomerase | Fructose and mannose metabolism | Binds 1 zinc ion per subunit (By similarity). | Nucleotide-sugar biosynthesis GDP-alpha-D-mannose biosynthesis alpha-D-mannose 1-phosphate from D-fructose 6- phosphate: step 1/2. | Unreviewed |  |  | IKU-IKUReaction | 1-1-1
R0265 | R02568 | D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase | D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase | D-Fructose 1-phosphate <=> Glycerone phosphate + D-Glyceraldehyde | C01094 <=> C00111 + C00577 | r |  | c | YALI0E26004g | 4.1.2.13 | fructose-bisphosphate aldolase |  | Fructose and mannose metabolism | Zinc. |  |  |  | Also acts on (3S,4R)-ketose 1-phosphates.The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.Formerly EC 4.1.2.7. | IKU-IKReaction | 1-1-n
R0266 | R02731 | D-Fructose-2,6-bisphosphate 2-phosphohydrolase | D-Fructose-2,6-bisphosphate 2-phosphohydrolase | beta-D-Fructose 2,6-bisphosphate + H2O <=> beta-D-Fructose 6-phosphate + Orthophosphate | C00665 + C00001 <=> C05345 + C00009 | irev | Forward | c | YALI0D21010g OR YALI0E17633g | 3.1.3.46 |  |  | Fructose and mannose metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-1
R0267 | R02732 | ATP:D-fructose-6-phosphate 2-phosphotransferase | ATP:D-fructose-6-phosphate 2-phosphotransferase | ATP + beta-D-Fructose 6-phosphate <=> ADP + beta-D-Fructose 2,6-bisphosphate | C00002 + C05345 <=> C00008 + C00665 | irev | Forward | c | YALI0F27885g OR YALI0E17633g OR YALI0D21010g | 2.7.1.105 |  |  | Fructose and mannose metabolism |  |  |  |  | Not identical with EC 2.7.1.11.The enzyme copurifies with EC 3.1.3.46. | IKU-IKReaction | n-1-1
R0268 | R03920 | ATP:D-fructose 6-phosphotransferase | ATP:D-fructose 6-phosphotransferase | ATP + beta-D-Fructose <=> ADP + beta-D-Fructose 6-phosphate | C00002 + C02336 <=> C00008 + C05345 | irev | Forward | c | YALI0B22308g OR [NAME] YALI0E20207g | 2.7.1.1 |  |  | Fructose and mannose metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0269 | R00220 | L-serine ammonia-lyase | L-serine ammonia-lyase | L-Serine <=> Pyruvate + NH3 | C00065 <=> C00022 + C00014 | r |  | c | YALI0D02497g | 4.3.1.19 | L-threonine ammonia-lyase |  | Glycine, serine and threonine metabolism | Pyridoxal 5'-phosphate. |  |  |  | The protein from Pseudomonas putida does not require pyridoxal- phosphate.The enzyme from a number of sources also acts on L-serine, cf. EC 4.3.1.17.The reaction catalyzed probably involves initial elimination of water (hence the enzyme's original classification as EC 4.2.1.16), followed by isomerization and hydrolysis of the product with C-N bond breakage.Formerly EC 4.2.1.16. | IKU-IKReaction | 1-1-n
R0270 | R00366 | glycine:oxygen oxidoreductase (deaminating); Aminoacetic acid:oxygen oxidoreductase (deaminating) | glycine:oxygen oxidoreductase (deaminating) | Glycine + H2O + Oxygen <=> Glyoxylate + NH3 + Hydrogen peroxide | C00037 + C00001 + C00007 <=> C00048 + C00014 + C00027 | irev | Forward | c | YALI0F31427g | 1.4.3.3 | D-amino-acid:oxygen oxidoreductase (deaminating) |  | Glycine, serine and threonine metabolism | FAD. |  |  |  | Wide specificity for D-amino acids.Also acts on glycine. | IKU-IKReaction | 1-1-n
R0271 | [NAME] | ATP:L-aspartate 4-phosphotransferase | ATP:L-aspartate 4-phosphotransferase | ATP + L-Aspartate <=> ADP + 4-Phospho-L-aspartate | C00002 + C00049 <=> C00008 + C03082 | irev | Forward | c | YALI0D11704g | 2.7.2.4 | aspartate kinase | Aspartokinase | Glycine, serine and threonine metabolism |  | Amino-acid biosynthesis L-threonine biosynthesis L- threonine from L-aspartate: step 1/5. | Unreviewed |  | The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 1.1.1.3. | IKU-IKUReaction | 1-1-1
R0272 | R00582 | O-phospho-L-serine phosphohydrolase | O-phospho-L-serine phosphohydrolase | O-Phospho-L-serine + H2O <=> L-Serine + Orthophosphate | C01005 + C00001 <=> C00065 + C00009 | irev | Forward | c | YALI0B20438g | 3.1.3.3 | hypothetical protein |  | Glycine, serine and threonine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0273 | R00751 | L-threonine acetaldehyde-lyase (glycine-forming) | L-threonine acetaldehyde-lyase (glycine-forming) | L-Threonine <=> Glycine + Acetaldehyde | C00188 <=> C00037 + C00084 | r |  | c | YALI0A21417g | 4.1.2.5 | hypothetical protein |  | Glycine, serine and threonine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0274 | R00945 | 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase | 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase | 5,10-Methylenetetrahydrofolate + Glycine + H2O <=> Tetrahydrofolate + L-Serine | C00143 + C00037 + C00001 <=> C00101 + C00065 | r |  | c | YALI0D22484g OR YALI0E16346g | 2.1.2.1 | hypothetical protein | Serine hydroxymethyltransferase | Glycine, serine and threonine metabolism | Pyridoxal 5'-phosphate | One-carbon metabolism tetrahydrofolate pathway. | Unreviewed |  | Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine. | IKU-IKUReaction | n-1-n
R0275 | R00996 | L-threonine ammonia-lyase (2-oxobutanoate-forming) | L-threonine ammonia-lyase (2-oxobutanoate-forming) | L-Threonine <=> 2-Oxobutanoate + NH3 | C00188 <=> C00109 + C00014 | irev | Forward | c | YALI0D02497g | 4.3.1.19 | L-threonine ammonia-lyase |  | Glycine, serine and threonine metabolism | Pyridoxal 5'-phosphate. |  |  |  | The protein from Pseudomonas putida does not require pyridoxal- phosphate.The enzyme from a number of sources also acts on L-serine, cf. EC 4.3.1.17.The reaction catalyzed probably involves initial elimination of water (hence the enzyme's original classification as EC 4.2.1.16), followed by isomerization and hydrolysis of the product with C-N bond breakage.Formerly EC 4.2.1.16. | IKU-IKReaction | 1-1-n
R0276 | R01001 | L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming) | L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming) | L-Cystathionine + H2O <=> L-Cysteine + NH3 + 2-Oxobutanoate | C02291 + C00001 <=> C00097 + C00014 + C00109 | r |  | c | YALI0F05874g | 4.4.1.1 | [NAME] |  | Glycine, serine and threonine metabolism | Pyridoxal 5'-phosphate. |  |  |  | Also catalyzes elimination reactions of L-homoserine to form H(2)O, NH(3) and 2-oxobutanoate, of L-cystine, producing thiocysteine, pyruvate and NH(3), and of L-cysteine producing pyruvate, NH(3) and H(2)S.Formerly EC 4.2.1.15. | IKU-IKReaction | 1-1-n
R0277 | R01290 | L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming) | L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming) | L-Serine + L-Homocysteine <=> L-Cystathionine + H2O | C00065 + C00155 <=> C02291 + C00001 | irev | Forward | c | YALI0E09108g | 4.2.1.22 | cystathionine beta-synthase |  | Glycine, serine and threonine metabolism | Pyridoxal 5'-phosphate. |  |  |  | A multifunctional enzyme: catalyzes beta-replacement reaction between L-serine, L-cysteine, cysteine thioethers or some other beta- substituted alpha-L-amino acids and a variety of mercaptans.Formerly EC 4.2.1.21. | IKU-IKReaction | 1-1-n
R0278 | R01466 | O-phospho-L-homoserine phosphate-lyase (adding water;L-threonine-forming) | O-phospho-L-homoserine phosphate-lyase (adding water;L-threonine-forming) | O-Phospho-L-homoserine + H2O <=> L-Threonine + Orthophosphate | C01102 + C00001 <=> C00188 + C00009 | irev | Forward | c | YALI0F23221g | 4.2.3.1 | L-threonine synthase |  | Glycine, serine and threonine metabolism | Pyridoxal 5'-phosphate. |  |  |  | Formerly EC 4.2.99.2. | IKU-IKReaction | 1-1-n
R0279 | R01513 | 3-Phospho-D-glycerate:NAD+ 2-oxidoreductase | 3-Phospho-D-glycerate:NAD+ 2-oxidoreductase | 3-Phospho-D-glycerate + NAD+ <=> 3-Phosphonooxypyruvate + NADH + H+ | C00197 + C00003 <=> C03232 + C00004 + C00080 | irev | Forward | c | YALI0F09966g | 1.1.1.95 | D-3-phosphoglycerate dehydrogenase |  | Glycine, serine and threonine metabolism |  |  |  |  | Catalyzes the first committed step in the phosphoserine pathway of serine biosynthesis in Escherichia coli.Reaction (1) occurs predominantly in the reverse direction and is inhibited by serine and glycine.The enzyme is unusual in that it also acts as a D- and L-2- hydroxyglutarate dehydrogenase (with the D-form being the better substrate) and as a 2-oxoglutarate reductase. | IKU-IKReaction | 1-1-1
R0280 | R01771 | ATP:L-homoserine O-phosphotransferase | ATP:L-homoserine O-phosphotransferase | ATP + L-Homoserine <=> ADP + O-Phospho-L-homoserine | C00002 + C00263 <=> C00008 + C01102 | irev | Forward | c | YALI0F13453g | 2.7.1.39 | hypothetical protein |  | Glycine, serine and threonine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0281 | R01775 | L-homoserine:NADP+ oxidoreductase | L-homoserine:NADP+ oxidoreductase | L-Homoserine + NADP+ <=> L-Aspartate 4-semialdehyde + NADPH + H+ | C00263 + C00006 <=> C00441 + C00005 + C00080 | r |  | c | [NAME] | 1.1.1.3 | homoserine dehydrogenase | Homoserine dehydrogenase | Glycine, serine and threonine metabolism |  | Amino-acid biosynthesis L-threonine biosynthesis L- threonine from L-aspartate: step 3/5. | Unreviewed |  | The enzyme from Saccharomyces cerevisiae acts most rapidly with NAD(+); the Neurospora enzyme with NADP(+).The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 2.7.2.4. | IKU-IKUReaction | 1-1-n
R0282 | [NAME] | L-Aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating) | L-Aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating) | L-Aspartate 4-semialdehyde + Orthophosphate + NADP+ <=> 4-Phospho-L-aspartate + NADPH + H+ | C00441 + C00009 + C00006 <=> C03082 + C00005 + C00080 | irev | Backward | c | YALI0D13596g | 1.2.1.11 | aspartate semialdehyde dehydrogenase | Aspartate-semialdehyde dehydrogenase | Glycine, serine and threonine metabolism |  | Amino-acid biosynthesis L-threonine biosynthesis L- threonine from L-aspartate: step 2/5. | Unreviewed |  |  | IKU-IKUReaction | 1-1-1
[NAME] | R03425 | glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating) | glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating) | [NAME] <=> S-Aminomethyldihydrolipoylprotein + CO2 | C00037 + C02051 <=> C01242 + C00011 | r |  | m | [NAME]g | 1.4.4.2 | glycine dehydrogenase (decarboxylating)beta subunit |  | Glycine, serine and threonine metabolism | Pyridoxal 5'-phosphate. |  |  |  | A component, with EC 2.1.2.10 and EC 1.8.1.4, of the glycine cleavage system, previously known as glycine synthase.The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein. | IKU-IKReaction | 1-1-1
R0285 | R03815 | dihydrolipoylprotein:NAD+ oxidoreductase | dihydrolipoylprotein:NAD+ oxidoreductase | Dihydrolipoylprotein + NAD+ <=> [NAME] H+ | C02972 + C00003 <=> C02051 + C00004 + C00080 | r |  | m | YALI0D20768g | 1.8.1.4 | dihydrolipoamide dehydrogenase | Dihydrolipoyl dehydrogenase | Glycine, serine and threonine metabolism | Binds 1 FAD per subunit (By similarity). |  | Unreviewed |  | A component of the multienzyme 2-oxo-acid dehydrogenase complexes.In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12 and catalyzes oxidation of its dihydrolipoyl groups.It plays a similar role in the oxoglutarate and 3-methyl-2- oxobutanoate dehydrogenase complexes.Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts, together with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine.It can also use free dihydrolipoate, dihydrolipoamide or dihydrolipoyllysine as substrate.Was first shown to catalyze the oxidation of NADH by methylene blue; this activity was called diaphorase.The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.Formerly EC 1.6.4.3. | IKU-IKUReaction | 1-1-n
R0286 | R04125 | S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) | S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) | S-Aminomethyldihydrolipoylprotein + Tetrahydrofolate <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + NH3 | C01242 + C00101 <=> C02972 + C00143 + C00014 | r |  | m | YALI0F02849g | 2.1.2.10 | aminomethyltransferase | Aminomethyltransferase | Glycine, serine and threonine metabolism |  |  | Unreviewed |  | A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase.The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein. | IKU-IKUReaction | 1-1-n
[NAME] | R04173 | 3-Phosphoserine:2-oxoglutarate aminotransferase | 3-Phosphoserine:2-oxoglutarate aminotransferase | O-Phospho-L-serine + 2-Oxoglutarate <=> 3-Phosphonooxypyruvate + L-Glutamate | C01005 + C00026 <=> C03232 + C00025 | r |  | c | YALI0F06468g | 2.6.1.52 | hypothetical protein |  | Glycine, serine and threonine metabolism | Pyridoxal 5'-phosphate. |  |  |  | Catalyzes the second step in the phosphorylated pathway of serine biosynthesis in Escherichia coli.Also catalyzes the third step in the biosynthesis of the coenzyme pyridoxal 5'-phosphate in E.coli (using reaction 2 above).In E.coli, pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate).Pyridoxal phosphate is the cofactor for both activities and therefore seems to be involved in its own biosynthesis.Non-phosphorylated forms of serine and threonine are not substrates. | IKU-IKReaction | 1-1-n
R0288 | R06171 | L-Allothreonine acetaldehyde-lyase | L-Allothreonine acetaldehyde-lyase | L-Allothreonine <=> Glycine + Acetaldehyde | C05519 <=> C00037 + C00084 | r |  | c | YALI0A21417g | 4.1.2.5 | hypothetical protein |  | Glycine, serine and threonine metabolism | Pyridoxal 5'-phosphate. |  |  |  |  | IKU-IKReaction | 1-1-n
R0289 | R00585 | L-Serine:pyruvate aminotransferase | L-Serine:pyruvate aminotransferase | L-Serine + Pyruvate <=> Hydroxypyruvate + L-Alanine | C00065 + C00022 <=> C00168 + C00041 | r |  | c | YALI0E16643g | 2.6.1.51 | alanine-glyoxylate aminotransferase apoenzyme |  | Glycine, serine and threonine metabolism | Pyridoxal 5'-phosphate. |  | Unreviewed |  |  | IKU-differenceReaction | 1-n-n
R0290 | R00588 | L-Serine:glyoxylate aminotransferase | L-Serine:glyoxylate aminotransferase | L-Serine + Glyoxylate <=> Hydroxypyruvate + Glycine | C00065 + C00048 <=> C00168 + C00037 | r |  | c | YALI0E16643g | 2.6.1.45 | alanine-glyoxylate aminotransferase apoenzyme |  | Glycine, serine and threonine metabolism | Pyridoxal 5'-phosphate. |  | Unreviewed |  |  | IKU-differenceReaction | 1-n-n
[NAME] | [NAME] | glutathione:NADP+ oxidoreductase | glutathione:NADP+ oxidoreductase | 2 Glutathione + NADP+ <=> Glutathione disulfide + NADPH + H+ | 2 C00051 + C00006 <=> C00127 + C00005 + C00080 | irev | Backward | c | YALI0E18029g | 1.8.1.7 | NADPH-glutathione reductase | Glutathione reductase | Glutathione metabolism | FAD |  | Reviewed | Cytoplasm (By similarity). | Activity is dependent on a redox-active disulfide in each of the active centers.Formerly EC 1.6.4.2. | IKU-IKUReaction | 1-1-1
R0292 | [NAME] | 5-oxo-L-proline amidohydrolase (ATP-hydrolysing) | 5-oxo-L-proline amidohydrolase (ATP-hydrolysing) | ATP + 5-Oxoproline + 2 H2O <=> ADP + Orthophosphate + L-Glutamate | C00002 + C01879 + 2 C00001 <=> C00008 + C00009 + C00025 | irev | Forward | c | YALI0E02398g | 3.5.2.9 | hypothetical protein |  | Glutathione metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0293 | R00274 | glutathione:hydrogen-peroxide oxidoreductase | glutathione:hydrogen-peroxide oxidoreductase | Hydrogen peroxide + 2 Glutathione <=> Glutathione disulfide + 2 H2O | [NAME] C00051 <=> C00127 + 2 C00001 | irev | Forward | c | YALI0E02310g | 1.11.1.9 | hypothetical protein |  | Glutathione metabolism | Selenium. |  |  |  | Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 on phospholipids, can act as acceptor, but more slowly than H(2)O(2) (cf. EC 1.11.1.12). | IKU-IKReaction | 1-1-n
R0294 | R00494 | glutathione gamma-glutamylaminopeptidase | glutathione gamma-glutamylaminopeptidase | Glutathione + H2O <=> [NAME] | C00051 + C00001 <=> C01419 + C00025 | irev | Forward | c | YALI0C11363g OR YALI0C20669g | 2.3.2.2 |  |  | Glutathione metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0295 | R00497 | gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming) | gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming) | ATP + gamma-L-Glutamyl-L-cysteine + Glycine <=> ADP + Orthophosphate + Glutathione | C00002 + C00669 + C00037 <=> C00008 + C00009 + C00051 | irev | Forward | c | YALI0C17831g | 6.3.2.3 | glutathione synthase |  | Glutathione metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0296 | R00894 | L-glutamate:L-cysteine gamma-ligase (ADP-forming) | L-glutamate:L-cysteine gamma-ligase (ADP-forming) | ATP + L-Glutamate + L-Cysteine <=> ADP + Orthophosphate + gamma-L-Glutamyl-L-cysteine | C00002 + C00025 + C00097 <=> C00008 + C00009 + C00669 | irev | Forward | c | YALI0E30129g | 6.3.2.2 | glutamate-cysteine ligase |  | Glutathione metabolism |  |  |  |  | Can use L-aminohexanoate in place of glutamate. | IKU-IKReaction | 1-1-1
R0303 | R01752 | D-Glyceraldehyde:NAD+ oxidoreductase | D-Glyceraldehyde:NAD+ oxidoreductase | D-Glyceraldehyde + NAD+ + H2O <=> D-Glycerate + NADH + H+ | C00577 + C00003 + C00001 <=> C00258 + C00004 + C00080 | r |  | c | YALI0B01298g OR YALI0C03025g OR YALI0E00264g OR YALI0F23793g | 1.2.1.3 |  |  | Glycerolipid metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0304 | R01011 | ATP:glycerone phosphotransferase | ATP:glycerone phosphotransferase | ATP + Glycerone <=> ADP + Glycerone phosphate | C00002 + C00184 <=> C00008 + C00111 | irev | Forward | c | YALI0F01606g OR YALI0F09273g | 2.7.1.29 |  |  | Glycerolipid metabolism |  |  |  |  |  | IKU-IKReaction | n-1-1
R0305 | R00847 | ATP:glycerol 3-phosphotransferase | ATP:glycerol 3-phosphotransferase | ATP + Glycerol <=> ADP + sn-Glycerol 3-phosphate | C00002 + C00116 <=> C00008 + C00093 | irev | Forward | c | YALI0F00484g | 2.7.1.30 | glycerol kinase |  | Glycerolipid metabolism |  |  |  |  | Glycerone and L-glyceraldehyde can act as acceptors.UTP (and, in the case of the Saccharomyces cerevisiae enzyme, ITP and GTP) can act as donors. | IKU-IKReaction | 1-1-1
R0307 |  | glycerol 3-phosphate acyltransferase (glycerol 3-phosphate), yeast-specific | glycerol 3-phosphate acyltransferase (glycerol 3-phosphate), yeast-specific | (0.02) dcacoa + (0.06) ddcacoa + glyc3p + (0.17) hdcoa + (0.09) [NAME] (0.24) odecoa + (0.27) pmtcoa + (0.05) stcoa + (0.1) tdcoa --> (0.01) 1ag3p_SC + coa |  | irev | Forward | c | YALI0C00209g | 2.3.1.15 | hypothetical protein |  | Glycerolipid metabolism |  |  | Unreviewed |  | At higher pH values the product, 7-O-acetylsalutaridinol, spontaneously closes the 4->5 oxide bridge by allylic elimination to form the morphine precursor thebaine.From the opium poppy plant, [NAME] somniferum. | IKU-IKReaction | 1-n-n
R0308 |  | 1-Acyl-glycerol-3-phosphate acyltransferase, yeast-specific | 1-Acyl-glycerol-3-phosphate acyltransferase, yeast-specific | (0.01) 1ag3p_SC + (0.02) dcacoa + (0.06) ddcacoa + (0.17) hdcoa + (0.09) [NAME] (0.24) odecoa + (0.27) pmtcoa + (0.05) stcoa + (0.1) tdcoa --> coa + (0.01) pa_SC |  | irev | Forward | c | [NAME] YALI0F10010g OR YALI0F19514g | 2.3.1.51 |  |  | Glycerolipid metabolism |  |  |  |  | Acyl-[acyl-carrier-protein] can also act as acyl donor.The animal enzyme is specific for the transfer of unsaturated fatty acyl groups. | IKU-IKReaction | n-1-1
[NAME] |  | diacylglycerol pyrophosphate phosphatase, yeast-specific | diacylglycerol pyrophosphate phosphatase, yeast-specific | h2o + (0.01) pa_SC --> (0.01) 12dgr_SC + pi |  | irev | Forward | c | YALI0D27016g | 3.1.3.4 |  |  | Glycerolipid metabolism |  |  |  |  | added recently
R0310 |  | triglycerol synthesis | triglycerol synthesis | (0.01) 12dgr_SC + (0.02) dcacoa + (0.06) ddcacoa + (0.17) hdcoa + (0.09) [NAME] (0.24) odecoa + (0.27) pmtcoa + (0.05) stcoa + (0.1) tdcoa --> coa + (0.01) triglyc_SC |  | irev | Forward | c | YALI0D07986g | 2.3.1.20 | Diacylglycerol O-acyltransferase |  | Glycerolipid metabolism |  |  |  |  | Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors. | IKU-IKReaction | 1-1-1
R0311 |  | phosphatidylcholine-diacylglycerol acyltransferase | phosphatidylcholine-diacylglycerol acyltransferase | 12dgr_SC + pc_SC --> 1agpc_SC + triglyc_SC |  | irev | Forward | c | [NAME] | 2.3.1.158 | phospholipid:diacylglycerol acyltransferase |  | Glycerolipid metabolism |  |  |  |  | This enzyme differs from EC 2.3.1.20 by synthesising triacylglycerol using an acyl-CoA-independent mechanism.The specificity of the enzyme for the acyl group in the phospholipid varies with species, e.g., the enzyme from castor bean (Ricinus communis) preferentially incorporates vernoloyl (12,13-epoxyoctadec- 9-enoyl) groups into triacylglycerol, whereas that from the hawk's beard (Crepis palaestina) incorporates both ricinoleoyl (12-hydroxyoctadec-9-enoyl) and vernoloyl groups.The enzyme from the yeast Saccharomyces cerevisiae specifically transfers acyl groups from the sn-2 position of the phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid. | IKU-IKReaction | 1-1-1
R0312 |  | Triacylglycerol lipase, yeast-specific | Triacylglycerol lipase, yeast-specific | h2o + (0.01) triglyc_SC --> (0.01) 12dgr_SC + (0.02) dca + (0.06) [NAME] (0.27) [NAME] (0.17) hdcea + (0.05) ocdca + (0.24) ocdcea + (0.09) [NAME]0.1) ttdca |  | irev | Forward | c | YALI0D17534g OR YALI0D19184g OR YALI0E31515g OR YALI0F10010g | 3.1.1.3 |  |  | Glycerolipid metabolism |  |  |  |  | The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolyzed. | IKU-IKReaction | n-1-n
R0313 | R00842 | sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase | sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase | sn-Glycerol 3-phosphate + NAD+ <=> Glycerone phosphate + NADH + H+ | C00093 + C00003 <=> C00111 + C00004 + C00080 | irev | Backward | c | YALI0B02948g | 1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) | Glycerol-3-phosphate dehydrogenase [NAD+] 1 | Glycerophospholipid metabolism |  |  | Reviewed | Cytoplasm (Probable). | Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity). | IKU-IKUReaction | 1-1-1
R0314 | R00842 | sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase | sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase | sn-Glycerol 3-phosphate + NAD+ <=> Glycerone phosphate + NADH + H+ | C00093 + C00003 <=> C00111 + C00004 + C00080 | irev | Backward | m | YALI0B02948g | 1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) | Glycerol-3-phosphate dehydrogenase [NAD+] 1 | Glycerophospholipid metabolism |  |  | Reviewed | Cytoplasm (Probable). | Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity). | IKU-IKUReaction | 1-1-1
[NAME] | R00848 | sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase | sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase | sn-Glycerol 3-phosphate + FAD <=> Glycerone phosphate + FADH2 | C00093 + C00016 <=> C00111 + C01352 | irev | Forward | m | [NAME] | 1.1.5.3 | [NAME] 3-phosphate dehydrogenase (quinone)+D1299 |  | Glycerophospholipid metabolism | Flavin. |  |  |  | An essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis.In bacteria, the enzyme is localized to the cytoplasmic membrane, while in eukaryotes it is tightly bound to the outer surface of the inner mitochondrial membrane.In eukaryotes, this enzyme, together with the cytosolic enzyme EC 1.1.1.8 forms the glycerol-3-phosphate shuttle by which NADH produced in the cytosol, primarily from glycolysis, can be reoxidized to NAD(+) by the mitochondrial electron-transport chain.This shuttle plays a critical role in transferring reducing equivalents from cytosolic NADH into the mitochondrial matrix.Insect flight muscle uses only CoQ(10) as the physiological quinone whereas hamster and rat mitochondria use mainly CoQ(9).The enzyme is activated by calcium.Formerly EC 1.1.2.1 and EC 1.1.99.5. | IKU-IKReaction | 1-1-1
[NAME] | R01021 | ATP:choline phosphotransferase | ATP:choline phosphotransferase | ATP + Choline <=> ADP + Choline phosphate | C00002 + C00114 <=> C00008 + C00588 | irev | Forward | c | YALI0E16907g | 2.7.1.32 | [NAME] |  | Glycerophospholipid metabolism |  |  | Unreviewed |  | Ethanolamine and its methyl and ethyl derivatives can also act as acceptors. | IKU-differenceReaction | 1-1-1
R0317 | [NAME] | sn-Glycero-3-phosphocholine glycerophosphohydrolase | sn-Glycero-3-phosphocholine glycerophosphohydrolase | sn-glycero-3-Phosphocholine + H2O <=> Choline + sn-Glycerol 3-phosphate | C00670 + C00001 <=> C00114 + C00093 | irev | Forward | c | YALI0F08217g | 3.1.4.46 | hypothetical protein |  | Glycerophospholipid metabolism |  |  |  |  | Broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol and bis(glycerophospho)-glycerol are hydrolyzed. | IKU-IKReaction | 1-1-n
R0318 | [NAME] | Phosphatidylcholine phosphatidohydrolase | Phosphatidylcholine phosphatidohydrolase | Phosphatidylcholine + H2O <=> Phosphatidate + Choline | C00157 + C00001 <=> C00416 + C00114 | irev | Forward | c | YALI0E18898g | 3.1.4.4 | hypothetical protein |  | Glycerophospholipid metabolism |  |  |  |  | Also acts on other phosphatidyl esters. | IKU-IKReaction | 1-1-n
R0319 |  | Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase | Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase | (0.01) 1agpc_SC + (0.02) dcacoa + (0.06) ddcacoa + (0.17) hdcoa + (0.09) [NAME] (0.24) odecoa + (0.27) pmtcoa + (0.05) stcoa + (0.1) tdcoa --> coa + (0.01) pc_SC |  | irev | Forward | c | YALI0F19514g | 2.3.1.23 | hypothetical protein |  | Glycerophospholipid metabolism |  |  | Unreviewed |  | Acts preferentially with unsaturated acyl-CoA derivatives.1-acyl-sn-glycero-3-phosphoinositol can also act as acceptor. | IKU-IKReaction | 1-n-n
R0320 | R01468 | ATP:ethanolamine O-phosphotransferase | ATP:ethanolamine O-phosphotransferase | ATP + Ethanolamine <=> ADP + Ethanolamine phosphate | C00002 + C00189 <=> C00008 + C00346 | irev | Forward | c | [NAME] | 2.7.1.82 | [NAME] |  | Glycerophospholipid metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0323 | R01890 | CTP:choline-phosphate cytidylyltransferase | CTP:choline-phosphate cytidylyltransferase | CTP + Choline phosphate <=> Diphosphate + CDP-choline | C00063 + C00588 <=> C00013 + C00307 | irev | Forward | c | YALI0D18271g | 2.7.7.15 | choline-phosphate cytidylyltransferase |  | Glycerophospholipid metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
[NAME] | R02038 | CTP:ethanolamine-phosphate cytidylyltransferase | CTP:ethanolamine-phosphate cytidylyltransferase | CTP + Ethanolamine phosphate <=> Diphosphate + CDP-ethanolamine | C00063 + C00346 <=> C00013 + C00570 | irev | Forward | c | YALI0C06303g | 2.7.7.14 | choline-phosphate cytidylyltransferase |  | Glycerophospholipid metabolism |  |  | Unreviewed |  |  | IKU-differenceReaction | 1-1-1
R0325 | R02051 | Phosphatidylethanolamine phosphatidohydrolase | Phosphatidylethanolamine phosphatidohydrolase | Phosphatidylethanolamine + H2O <=> [NAME] | C00350 + C00001 <=> C00189 + C00416 | irev | Forward | c | YALI0E18898g | 3.1.4.4 | hypothetical protein |  | Glycerophospholipid metabolism |  |  |  |  | Also acts on other phosphatidyl esters. | IKU-IKReaction | 1-1-n
R0334 |  | phosphatidylserine synthase, yeast-specific | phosphatidylserine synthase, yeast-specific | (0.01) cdpdag_SC + ser-L <==> cmp + h + (0.01) ps_SC |  | r |  | c | [NAME] | 2.7.8.8 | hypothetical protein |  | Glycerophospholipid metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0335 |  | glycerol 3-phosphate acyltransferase (glycerone phosphate), yeast-specific | glycerol 3-phosphate acyltransferase (glycerone phosphate), yeast-specific | (0.02) dcacoa + (0.06) ddcacoa + dhap + (0.17) hdcoa + (0.09) [NAME] (0.24) odecoa + (0.27) pmtcoa + (0.05) stcoa + (0.1) tdcoa --> (0.01) 1agly3p_SC + coa |  | irev | Forward | c | YALI0C00209g | 2.3.1.42 | hypothetical protein |  | Glycerophospholipid metabolism |  |  | Unreviewed |  | Uses CoA derivatives of palmitate, stearate, and oleate, with highest activity on palmitoyl-CoA. | IKU-IKReaction | 1-n-n
R0336 |  | acyldihydroxyacetonephosphate reductase, yeast-specific | acyldihydroxyacetonephosphate reductase, yeast-specific | (0.01) 1agly3p_SC + h + nadph --> (0.01) 1ag3p_SC + nadp |  | irev | Forward | c |  |  |  |  | Glycerophospholipid metabolism
R0337 |  | CDP-Diacylglycerol synthetase, yeast-specific | CDP-Diacylglycerol synthetase, yeast-specific | ctp + h + (0.01) pa_SC <==> (0.01) cdpdag_SC + ppi |  | r |  | c | YALI0E14443g | 2.7.7.41 | phosphatidate cytidylyltransferase | Phosphatidate cytidylyltransferase | Glycerophospholipid metabolism |  | Phospholipid metabolism CDP-diacylglycerol biosynthesis CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. | Unreviewed |  |  | IKU-IKUReaction | 1-1-1
R0338 |  | phosphatidylserine decarboxylase, yeast-specific, Golgi apparatus | phosphatidylserine decarboxylase, yeast-specific, Golgi apparatus | h + (0.01) ps_SC --> co2 + (0.01) pe_SC |  | irev | Forward | c | YALI0D03480g OR YALI0D21604g | 4.1.1.65 |  |  | Glycerophospholipid metabolism |  |  |  |  |  | IKU-IKReaction | n-1-1
R0339 |  | phosphatidylethanolamine N-methyltransferase, yeast-specific | phosphatidylethanolamine N-methyltransferase, yeast-specific | amet + (0.01) pe_SC --> ahcys + h + (0.01) ptdmeeta_SC |  | irev | Forward | c | YALI0E06061g | 2.1.1.17 | phosphatidylethanolamine N-methyltransferase | Phosphatidylethanolamine N-methyltransferase | Glycerophospholipid metabolism |  | Phospholipid metabolism phosphatidylcholine biosynthesis. | Reviewed | [NAME]-pass membrane protein. |  | IKU-IKUReaction | 1-1-1
R0341 |  | [NAME], yeast-specific | [NAME], yeast-specific | (0.01) 12dgr_SC + cdpchol --> cmp + h + (0.01) pc_SC |  | irev | Forward | c | YALI0C10989g |  |  |  | Glycerophospholipid metabolism |  |  |  |  | added manually
R0342 |  | Ethanolaminephosphotransferase, yeast-specific | Ethanolaminephosphotransferase, yeast-specific | (0.01) 12dgr_SC + cdpea <==> cmp + h + (0.01) pe_SC |  | r |  | c | YALI0C10989g |  |  |  | Glycerophospholipid metabolism |  |  |  |  | added manually
R0343 |  | phosphatidylglycerol phosphate phosphatase A, yeast-specific, mitochondrial | phosphatidylglycerol phosphate phosphatase A, yeast-specific, mitochondrial | h2o + (0.01) pgp_SC --> (0.01) pg_SC + pi |  | irev | Forward | m |  |  |  |  | Glycerophospholipid metabolism
R0344 |  | CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase | CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase | (0.01) cdpdag_SC + glyc3p <==> cmp + h + (0.01) pgp_SC |  | irev | Forward | m | YALI0E14102g | 2.7.8.5 | phosphatidylglycerolphosphate synthase |  | Glycerophospholipid metabolism |  |  | Unreviewed |  |  | IKU-differenceReaction | 1-1-1
R0345 |  | cardiolipin synthase, yeast-specific, mitochondrial | cardiolipin synthase, yeast-specific, mitochondrial | (0.01) cdpdag_SC + (0.01) pg_SC --> (0.01) clpn_SC + cmp + h |  | irev | Forward | m | YALI0F23837g | 2.7.8.- |  |  | Glycerophospholipid metabolism
R0346 |  | CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase | CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase | (0.01) cdpdag_SC + inost --> cmp + h + (0.01) ptd1ino_SC |  | irev | Forward | c | YALI0F20328g | 2.7.8.11 | CDP-diacylglycerol inositol 3-phosphatidyltransferase |  | Glycerophospholipid metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0347 | R01185 | 1D-myo-Inositol 1-phosphate phosphohydrolase | 1D-myo-Inositol 1-phosphate phosphohydrolase | Inositol 1-phosphate + H2O <=> myo-Inositol + Orthophosphate | C01177 + C00001 <=> C00137 + C00009 | irev | Forward | c | YALI0D04378g | 3.1.3.25 | hypothetical protein |  | Inositol phosphate metabolism |  |  |  |  | Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group.It also acts on adenosine 2'-phosphate (but not the 3'- or 5'-phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate, but does not act on inositol bisphosphates or more phosphorylated inositols. | IKU-IKReaction | 1-1-n
R0348 | R01186 | 1D-myo-Inositol 4-phosphate phosphohydrolase | 1D-myo-Inositol 4-phosphate phosphohydrolase | myo-Inositol 4-phosphate + H2O <=> myo-Inositol + Orthophosphate | C03546 + C00001 <=> C00137 + C00009 | irev | Forward | c | YALI0D04378g | 3.1.3.25 | hypothetical protein |  | Inositol phosphate metabolism |  |  |  |  | Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group.It also acts on adenosine 2'-phosphate (but not the 3'- or 5'-phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate, but does not act on inositol bisphosphates or more phosphorylated inositols. | IKU-IKReaction | 1-1-n
R0349 | R01187 | 1D-myo-Inositol 3-phosphate phosphohydrolase | 1D-myo-Inositol 3-phosphate phosphohydrolase | 1D-myo-Inositol 3-phosphate + H2O <=> myo-Inositol + Orthophosphate | C04006 + C00001 <=> C00137 + C00009 | irev | Forward | c | YALI0D04378g | 3.1.3.25 | hypothetical protein |  | Inositol phosphate metabolism |  |  |  |  | Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group.It also acts on adenosine 2'-phosphate (but not the 3'- or 5'-phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate, but does not act on inositol bisphosphates or more phosphorylated inositols. | IKU-IKReaction | 1-1-n
R0350 | [NAME] | 1-Phosphatidyl-D-myo-inositol inositolphosphohydrolase | 1-Phosphatidyl-D-myo-inositol inositolphosphohydrolase | 1-Phosphatidyl-D-myo-inositol + H2O <=> Inositol 1-phosphate + 1,2-Diacyl-sn-glycerol | C01194 + C00001 <=> C01177 + C00641 | irev | Forward | c | [NAME] | 4.6.1.13 | hypothetical protein |  | Inositol phosphate metabolism |  |  |  |  | This enzyme is bacterial.Activity is also found in animals, but this activity is due to the presence of EC 3.1.4.11.Formerly EC 3.1.4.10. | IKU-IKReaction | 1-1-1
R0351 |  | phosphatidylinositol 4-kinase, yeast-specific | phosphatidylinositol 4-kinase, yeast-specific | atp + (0.01) ptd1ino_SC --> adp + h + (0.01) ptd4ino_SC |  | irev | Forward | c | YALI0B02376g OR YALI0E28153g | 2.7.1.67 |  |  | Inositol phosphate metabolism |  |  |  |  |  | IKU-IKReaction | n-1-1
R0352 |  | 1-phosphatidylinositol 3-kinase, yeast-specific | 1-phosphatidylinositol 3-kinase, yeast-specific | atp + (0.01) ptd1ino_SC --> adp + h + (0.01) ptd3ino_SC |  | irev | Forward | c | YALI0F09559g | 2.7.1.137 | phosphatidylinositol 3-kinase |  | Inositol phosphate metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0353 |  | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, yeast-specific | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, yeast-specific | h2o + (0.01) ptd145bp_SC --> (0.01) 12dgr_SC + h + mi145tp-D |  | irev | Forward | c | YALI0C04180g | 3.1.4.11 | phosphatidylinositol-4,5-bisphosphate phosphodiesterase |  | Inositol phosphate metabolism |  |  |  |  | These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3).They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration. | IKU-IKReaction | 1-1-1
R0354 |  | phosphatidylinositol-4-phosphate 5-kinase, yeast-specfic | phosphatidylinositol-4-phosphate 5-kinase, yeast-specfic | atp + (0.01) ptd4ino_SC --> adp + h + (0.01) ptd145bp_SC |  | irev | Forward | c | YALI0F23573g | 2.7.1.68 | phosphatidylinositol-4-phosphate 5-kinase |  | Inositol phosphate metabolism |  |  |  |  | This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P(2) in the 5-position in vitro, but to a lesser extent.The last of these reactions occurs in vivo and is physiologically relevant. | IKU-IKReaction | 1-1-1
R0355 |  | ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase | ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase | ATP + (0.01) 1-Phosphatidyl-1D-myo-inositol 3-phosphate <=> ADP + (0.01) 1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate | C00002 + (0.01) C04549 <=> C00008 + (0.01) C11556 | irev | Forward | c | YALI0E29161g | 2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase |  | Inositol phosphate metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0356 |  | 1D-myo-inositol-3-phosphate lyase (isomerizing) | 1D-myo-inositol-3-phosphate lyase (isomerizing) | alpha-D-Glucose 6-phosphate <=> 1D-myo-Inositol 3-phosphate | C00668 <=> C04006 | irev | Forward | c | YALI0B04312g | 5.5.1.4 | hypothetical protein |  | Inositol phosphate metabolism | NAD. |  |  |  | The NAD(+) dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1; finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form. | IKU-IKReaction | 1-1-1
R0357 | R00014 | pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating) | pyruvate:thiamin diphosphate acetal dehydetransferase (decarboxylating) | Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2 | C00022 + C00068 <=> C05125 + C00011 | irev | Forward | c | (YALI0E27005g AND YALI0F20702g) OR YALI0D10131g | 1.2.4.1 OR 4.1.1.1 |  |  | Glycolysis/Gluconeogenesis |  |  | Unreviewed OR Unreviewed |  |  | IKU-IKReaction OR IKU-IKReaction | n-1-n OR 1-n-n
R0358 | R00235 | Acetate:CoA ligase (AMP-forming) | Acetate:CoA ligase (AMP-forming) | ATP + Acetate + CoA <=> AMP + Diphosphate + Acetyl-CoA | C00002 + C00033 + C00010 <=> C00020 + C00013 + C00024 | irev | Forward | c | [NAME] | 6.2.1.1 | acetyl-coenzyme A synthetase |  | Glycolysis/Gluconeogenesis |  |  |  |  | Also acts on propanoate and propenoate. | IKU-IKReaction | 1-1-n
R0359 | R00341 | ATP:oxaloacetate carboxy-lyase (transphosphorylating;phosphoenolpyruvate-forming) | ATP:oxaloacetate carboxy-lyase (transphosphorylating;phosphoenolpyruvate-forming) | ATP + Oxaloacetate <=> ADP + Phosphoenolpyruvate + CO2 | C00002 + C00036 <=> C00008 + C00074 + C00011 | irev | Forward | c | YALI0C16995g | 4.1.1.49 | hypothetical protein |  | Glycolysis/Gluconeogenesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0360 | R00658 | 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming) | 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming) | 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O | C00631 <=> C00074 + C00001 | r |  | c | YALI0F16819g | 4.2.1.11 | enolase | Enolase | Glycolysis/Gluconeogenesis | Magnesium. Required for catalysis and for stabilizing the dimer (By similarity). | Carbohydrate degradation glycolysis pyruvate from D- glyceraldehyde 3-phosphate: step 4/5. | Reviewed | Cytoplasm (By similarity). | Also acts on 3-phospho-D-erythronate. | IKU-IKUReaction | 1-1-1
R0361 | R00710 | Acetaldehyde:NAD+ oxidoreductase | Acetaldehyde:NAD+ oxidoreductase | Acetaldehyde + NAD+ + H2O <=> Acetate + NADH + H+ | C00084 + C00003 + C00001 <=> C00033 + C00004 + C00080 | irev | Forward | m | YALI0B01298g OR YALI0C03025g OR YALI0E00264g OR YALI0F23793g | 1.2.1.3 |  |  | Glycolysis/Gluconeogenesis |  |  |  |  |  | IKU-IKReaction | n-1-n
R0362 | R00711 | Acetaldehyde:NADP+ oxidoreductase | Acetaldehyde:NADP+ oxidoreductase | Acetaldehyde + NADP+ + H2O <=> Acetate + NADPH + H+ | C00084 + C00006 + C00001 <=> C00033 + C00005 + C00080 | irev | Forward | m | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Glycolysis/Gluconeogenesis |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0363 | [NAME] | ethanol:NAD+ oxidoreductase | ethanol:NAD+ oxidoreductase | Ethanol + NAD+ <=> Acetaldehyde + NADH + H+ | C00469 + C00003 <=> C00084 + C00004 + C00080 | r |  | c | YALI0A15147g OR [NAME] YALI0D25630g OR YALI0E17787g OR YALI0F09603g | 1.1.1.1 |  |  | Glycolysis/Gluconeogenesis | Zinc or iron. |  |  |  | Acts on primary or secondary alcohols or hemiacetals.The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols. | IKU-IKReaction | n-1-n
R0364 | R00755 | NO NAME | NO NAME | Acetaldehyde + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate | C00084 + C00068 <=> C05125 | irev | Backward | c | YALI0D10131g | 4.1.1.1 | hypothetical protein |  | Glycolysis/Gluconeogenesis | Thiamine diphosphate. |  | Unreviewed |  | Also catalyzes acyloin formation. | IKU-IKReaction | 1-n-n
R0365 | R00959 | alpha-D-Glucose 1-phosphate 1,6-phosphomutase | alpha-D-Glucose 1-phosphate 1,6-phosphomutase | D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate | C00103 <=> C00668 | r |  | c | YALI0E02090g OR YALI0E02244g | 5.4.2.2 |  |  | Glycolysis/Gluconeogenesis |  |  |  |  | Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate.This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization.Also, more slowly, catalyzes the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate.Formerly EC 2.7.5.1. | IKU-IKReaction | n-1-n
R0366 | R01015 | D-glyceraldehyde-3-phosphate aldose-ketose-isomerase | D-glyceraldehyde-3-phosphate aldose-ketose-isomerase | D-Glyceraldehyde 3-phosphate <=> Glycerone phosphate | C00118 <=> C00111 | r |  | c | YALI0F01584g OR YALI0F05214g | 5.3.1.1 |  |  | Glycolysis/Gluconeogenesis |  |  |  |  |  | IKU-IKReaction | n-1-1
R0367 | R01061 | D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating) | D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating) | D-Glyceraldehyde 3-phosphate + Orthophosphate + NAD+ <=> 3-Phospho-D-glyceroyl phosphate + NADH + H+ | C00118 + C00009 + C00003 <=> C00236 + C00004 + C00080 | r |  | c | YALI0C06369g | 1.2.1.12 | glyceraldehyde-3-phosphate dehydrogenase | Glyceraldehyde-3-phosphate dehydrogenase | Glycolysis/Gluconeogenesis |  | Carbohydrate degradation glycolysis pyruvate from D- glyceraldehyde 3-phosphate: step 1/5. | Reviewed | Cytoplasm (By similarity). | Also acts very slowly on D-glyceraldehyde and some other aldehydes. | IKU-IKUReaction | 1-1-1
R0368 | R01070 | beta-D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming) | beta-D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming) | beta-D-Fructose 1,6-bisphosphate <=> Glycerone phosphate + D-Glyceraldehyde 3-phosphate | C05378 <=> C00111 + C00118 | r |  | c | YALI0E26004g | 4.1.2.13 | fructose-bisphosphate aldolase |  | Glycolysis/Gluconeogenesis | Zinc. |  |  |  | Also acts on (3S,4R)-ketose 1-phosphates.The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.Formerly EC 4.1.2.7. | IKU-IKReaction | 1-1-n
R0369 | R01512 | ATP:3-phospho-D-glycerate 1-phosphotransferase | ATP:3-phospho-D-glycerate 1-phosphotransferase | ATP + 3-Phospho-D-glycerate <=> ADP + 3-Phospho-D-glyceroyl phosphate | C00002 + C00197 <=> C00008 + C00236 | r |  | c | [NAME] | 2.7.2.3 | phosphoglycerate kinase | Phosphoglycerate kinase | Glycolysis/Gluconeogenesis |  | Carbohydrate degradation glycolysis pyruvate from D- glyceraldehyde 3-phosphate: step 2/5. | Reviewed | Cytoplasm (By similarity). |  | IKU-IKUReaction | 1-1-1
R0370 | R01518 | 2-Phospho-D-glycerate 2,3-phosphomutase | 2-Phospho-D-glycerate 2,3-phosphomutase | 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate | C00631 <=> C00197 | r |  | c | YALI0B02728g OR YALI0D09229g OR YALI0D16445g | 5.4.2.1 |  |  | Glycolysis/Gluconeogenesis |  |  |  |  | The enzymes from mammals and from Saccharomyces cerevisiae are phosphorylated by (2R)-2,3-diphosphoglycerate, which is also an intermediate.With the rabbit muscle enzyme, dissociation of bisphosphate from the enzyme is much slower that the overall isomerization.Also catalyze, slowly, the reactions of EC 5.4.2.4.Enzymes from wheat, rice, insects and some fungi, however, have maximum activity in the absence of 2,3-diphosphophosphoglycerate, and were formerly listed under the present number as phosphoglycerate phosphomutase.Formerly EC 2.7.5.3. | IKU-IKReaction | n-1-1
R0371 | R01600 | ATP:beta-D-glucose 6-phosphotransferase | ATP:beta-D-glucose 6-phosphotransferase | ATP + beta-D-Glucose <=> ADP + beta-D-Glucose 6-phosphate | C00002 + C00221 <=> C00008 + C01172 | irev | Forward | c | YALI0B22308g OR [NAME] YALI0E20207g | 2.7.1.1 |  |  | Glycolysis/Gluconeogenesis |  |  |  |  |  | IKU-IKReaction | n-1-n
R0374 | R02569 | acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase | acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase | Acetyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine | C00024 + C15973 <=> C00010 + C16255 | r |  | m | YALI0D23683g | 2.3.1.12 | hypothetical protein |  | Glycolysis/Gluconeogenesis |  |  |  |  | A multimer (24-mer or 60-mer, depending on the source) of this enzyme forms the core of the pyruvate dehydrogenase multienzyme complex, and binds tightly both EC 1.2.4.1 and EC 1.8.1.4.The lipoyl group of this enzyme is reductively acetylated by EC 1.2.4.1, and the only observed direction catalyzed by EC 2.3.1.12 is that where the acetyl group is passed to coenzyme A. | IKU-IKReaction | 1-1-1
R0376 | R02740 | alpha-D-Glucose 6-phosphate ketol-isomerase | alpha-D-Glucose 6-phosphate ketol-isomerase | alpha-D-Glucose 6-phosphate <=> beta-D-Fructose 6-phosphate | C00668 <=> C05345 | r |  | c | YALI0F07711g | 5.3.1.9 | glucose-6-phosphate isomerase | Glucose-6-phosphate isomerase | Glycolysis/Gluconeogenesis |  | Carbohydrate degradation glycolysis D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 2/4. | Unreviewed | Cytoplasm (By similarity). | Also catalyzes the anomerization of D-glucose 6-phosphate. | IKU-IKUReaction | 1-1-n
R0377 | R03270 | NO NAME | NO NAME | 2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate | C05125 + C15972 <=> C16255 + C00068 | irev | Forward | m | YALI0E27005g AND YALI0F20702g | 1.2.4.1 |  |  | Glycolysis/Gluconeogenesis |  |  |  |  |  | IKU-IKReaction | n-1-n
R0379 | R04779 | ATP:D-fructose-6-phosphate 1-phosphotransferase | ATP:D-fructose-6-phosphate 1-phosphotransferase | ATP + beta-D-Fructose 6-phosphate <=> ADP + beta-D-Fructose 1,6-bisphosphate | C00002 + C05345 <=> C00008 + C05378 | irev | Forward | c | YALI0D16357g | 2.7.1.11 | 6-phosphofructokinase | 6-phosphofructokinase subunit alpha | Glycolysis/Gluconeogenesis |  | Carbohydrate degradation glycolysis D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 3/4. | Reviewed | Cytoplasm (By similarity). | D-tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors.UTP, CTP and ITP can act as donors.Not identical with EC 2.7.1.105. | IKU-IKUReaction | 1-1-n
R0380 | R04780 | beta-D-Fructose 1,6-bisphosphate 1-phosphohydrolase | beta-D-Fructose 1,6-bisphosphate 1-phosphohydrolase | beta-D-Fructose 1,6-bisphosphate + H2O <=> beta-D-Fructose 6-phosphate + Orthophosphate | C05378 + C00001 <=> C05345 + C00009 | irev | Forward | c | YALI0A15972g | 3.1.3.11 | D-fructose 1,6-bisphosphatase |  | Glycolysis/Gluconeogenesis |  |  |  |  | The animal enzyme also acts on sedoheptulose 1,7-bisphosphate. | IKU-IKReaction | 1-1-n
R0381 | R07618 | enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase | enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase | Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+ | C15973 + C00003 <=> C15972 + C00004 + C00080 | irev | Forward | m | YALI0D20768g | 1.8.1.4 | dihydrolipoamide dehydrogenase | Dihydrolipoyl dehydrogenase | Glycolysis/Gluconeogenesis | Binds 1 FAD per subunit (By similarity). |  | Unreviewed |  | A component of the multienzyme 2-oxo-acid dehydrogenase complexes.In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12 and catalyzes oxidation of its dihydrolipoyl groups.It plays a similar role in the oxoglutarate and 3-methyl-2- oxobutanoate dehydrogenase complexes.Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts, together with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine.It can also use free dihydrolipoate, dihydrolipoamide or dihydrolipoyllysine as substrate.Was first shown to catalyze the oxidation of NADH by methylene blue; this activity was called diaphorase.The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.Formerly EC 1.6.4.3. | IKU-IKUReaction | 1-1-n
R0382 | R00200 | ATP:pyruvate 2-O-phosphotransferase | ATP:pyruvate 2-O-phosphotransferase | ATP + Pyruvate <=> ADP + Phosphoenolpyruvate | C00002 + C00022 <=> C00008 + C00074 | irev | Backward | c | YALI0F09185g | 2.7.1.40 | pyruvate kinase | Pyruvate kinase | Glycolysis/Gluconeogenesis | Potassium. | Carbohydrate degradation glycolysis pyruvate from D- glyceraldehyde 3-phosphate: step 5/5. | Reviewed |  | UTP, GTP, CTP, ITP and dATP can also act as donors.Also phosphorylates hydroxylamine and fluoride in the presence of CO(2). | IKU-IKUReaction | 1-1-n
R0383 | R00351 | acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing) | acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing) | Citrate + CoA <=> Acetyl-CoA + H2O + Oxaloacetate | C00158 + C00010 <=> C00024 + C00001 + C00036 | irev | Backward | x | YALI0E00638g OR YALI0E02684g | 2.3.3.1 |  |  | Glyoxylate and dicarboxylate metabolism |  |  |  |  |  | IKU-IKReaction | n-1-1
R0384 | R00472 | acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); L-Malate glyoxylate-lyase (CoA-acetylating) | L-Malate glyoxylate-lyase (CoA-acetylating) | (S)-Malate + CoA <=> Acetyl-CoA + H2O + Glyoxylate | C00149 + C00010 <=> C00024 + C00001 + C00048 | r |  | x | YALI0D19140g OR YALI0E15708g | 2.3.3.9 | hypothetical protein | Malate synthase | Glyoxylate and dicarboxylate metabolism |  | Carbohydrate metabolism glyoxylate cycle (S)-malate from isocitrate: step 2/2. | Unreviewed |  | Formerly EC 4.1.3.2. | IKU-IKUReaction | n-1-1
R0385 | R00475 | Glycolate:oxygen 2-oxidoreductase | Glycolate:oxygen 2-oxidoreductase | Glycolate + Oxygen <=> Glyoxylate + Hydrogen peroxide | C00160 + C00007 <=> C00048 + C00027 | irev | Forward | c | YALI0D12661g | 1.1.3.15 | hypothetical protein |  | Glyoxylate and dicarboxylate metabolism | FMN. |  |  |  | Exists as two major isoenzymes; the A form preferentially oxidizes short-chain aliphatic hydroxy acids; the B form preferentially oxidizes long-chain and aromatic hydroxy acids.The rat isoenzyme B also acts as EC 1.4.3.2.Formerly EC 1.1.3.1. | IKU-IKReaction | 1-1-1
R0386 | R00479 | isocitrate glyoxylate-lyase (succinate-forming) | isocitrate glyoxylate-lyase (succinate-forming) | Isocitrate <=> Succinate + Glyoxylate | C00311 <=> C00042 + C00048 | irev | Forward | x | YALI0C16885g OR YALI0F31999g | 4.1.3.1 |  |  | Glyoxylate and dicarboxylate metabolism |  |  |  |  | The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3- tricarboxylate. | IKU-IKReaction | n-1-1
R0387 | R00342 | (S)-malate:NAD+ oxidoreductase | (S)-malate:NAD+ oxidoreductase | (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ | C00149 + C00003 <=> C00036 + C00004 + C00080 | r |  | c | YALI0D16753g OR YALI0E14190g | 1.1.1.37 | malate dehydrogenase (NAD) | Malate dehydrogenase | Glyoxylate and dicarboxylate metabolism |  |  |  |  | Also oxidizes some other 2-hydroxydicarboxylic acids. | IKU-IKUReaction | n-1-1
R0388 | R01324 | citrate hydroxymutase | citrate hydroxymutase | Citrate <=> Isocitrate | C00158 <=> C00311 | r |  | x | YALI0D09361g OR YALI0E14949g | 4.2.1.3 |  |  | Glyoxylate and dicarboxylate metabolism | Iron-sulfur. |  |  |  | Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate.The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate.Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate. | IKU-IKReaction | n-1-n
R0389 | R01071 | 1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase | 1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase | 1-(5-Phospho-D-ribosyl)-ATP + Diphosphate <=> ATP + 5-Phospho-alpha-D-ribose 1-diphosphate | C02739 + C00013 <=> C00002 + C00119 | irev | Backward | c | YALI0C05170g | 2.4.2.17 | ATP phosphoribosyltransferase (homohexameric) | ATP phosphoribosyltransferase | Histidine metabolism |  | Amino-acid biosynthesis L-histidine biosynthesis L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. | Reviewed | Cytoplasm (By similarity). |  | IKU-IKUReaction | 1-1-1
R0390 | R03013 | L-Histidinol-phosphate phosphohydrolase | L-Histidinol-phosphate phosphohydrolase | L-Histidinol phosphate + H2O <=> L-Histidinol + Orthophosphate | [NAME] <=> C00860 + C00009 | irev | Forward | c | YALI0E05049g | 3.1.3.15 | hypothetical protein |  | Histidine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0391 | R03243 | 5-Amino-2-oxopentanoate:2-oxoglutarate aminotransferase | 5-Amino-2-oxopentanoate:2-oxoglutarate aminotransferase | L-Histidinol phosphate + 2-Oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl phosphate + L-Glutamate | [NAME] C00026 <=> C01267 + C00025 | r |  | c | YALI0E01254g | 2.6.1.9 | histidinol phosphate aminotransferase apoenzyme |  | Histidine metabolism | Pyridoxal 5'-phosphate. |  |  |  |  | IKU-IKReaction | 1-1-n
R0392 | [NAME] | D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate hydro-lyase | D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate hydro-lyase | D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate <=> 3-(Imidazol-4-yl)-2-oxopropyl phosphate + H2O | C04666 <=> C01267 + C00001 | irev | Forward | c | YALI0E33957g | 4.2.1.19 | imidazoleglycerol-phosphate dehydratase | Imidazoleglycerol-phosphate dehydratase | Histidine metabolism |  | Amino-acid biosynthesis L-histidine biosynthesis L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. | Unreviewed |  |  | IKU-IKUReaction | 1-1-1
R0393 | [NAME] | Phosphoribosyl-ATP pyrophosphohydrolase | Phosphoribosyl-ATP pyrophosphohydrolase | 1-(5-Phospho-D-ribosyl)-ATP + H2O <=> Phosphoribosyl-AMP + Diphosphate | C02739 + C00001 <=> C02741 + C00013 | irev | Forward | c | YALI0A15950g | 3.6.1.31 | histidinol dehydrogenase |  | Histidine metabolism |  |  | Unreviewed |  | The Neurospora crassa enzyme also catalyzes the reactions of EC 1.1.1.23 and EC 3.5.4.19. | IKU-differenceReaction | 1-1-n
[NAME] | R04037 | 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase | 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase | Phosphoribosyl-AMP + H2O <=> 5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide | C02741 + C00001 <=> C04896 | irev | Forward | c | YALI0A15950g | 3.5.4.19 | histidinol dehydrogenase |  | Histidine metabolism |  |  | Unreviewed |  | The Neurospora crassa enzyme also catalyzes the reactions of EC 1.1.1.23 and EC 3.6.1.31. | IKU-differenceReaction | 1-1-n
R0396 | R04640 | N-(5'-Phospho-D-ribosylformimino)-5-amino-1- (5''-phospho-D-ribosyl)-4-imidazolecarboxamide ketol-isomerase | N-(5'-Phospho-D-ribosylformimino)-5-amino-1- (5''-phospho-D-ribosyl)-4-imidazolecarboxamide ketol-isomerase | 5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide <=> N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide | C04896 <=> C04916 | irev | Forward | c | YALI0F05192g | 5.3.1.16 | hypothetical protein | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase | Histidine metabolism |  | Amino-acid biosynthesis L-histidine biosynthesis L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. | Reviewed | Cytoplasm (By similarity). |  | IKU-IKUReaction | 1-1-1
[NAME] | R04558 | NO NAME | NO NAME | N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide + L-Glutamine <=> D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + L-Glutamate | C04916 + C00064 <=> C04666 + C04677 + C00025 | irev | Forward | c | YALI0C07128g | NULL |  |  | Histidine metabolism
[NAME] | R01158 | L-Histidinol:NAD+ oxidoreductase | L-Histidinol:NAD+ oxidoreductase | L-Histidinol + 2 NAD+ + H2O <=> L-Histidine + 2 NADH + 2 H+ | C00860 + 2 C00003 + C00001 <=> C00135 + 2 C00004 + 2 C00080 | irev | Forward | c | YALI0A15950g | 1.1.1.23 | histidinol dehydrogenase |  | Histidine metabolism |  |  | Unreviewed |  | Also oxidizes L-histidinal.The Neurospora enzyme also catalyzes the reactions of EC 3.5.4.19 and EC 3.6.1.31. | IKU-differenceReaction | 1-1-n
R0400 | [NAME] | Formate:NAD+ oxidoreductase | Formate:NAD+ oxidoreductase | Formate + NAD+ <=> H+ + CO2 + NADH | C00058 + C00003 <=> C00080 + C00011 + C00004 | irev | Forward | c | YALI0A12353g OR YALI0B22506g OR YALI0C08074g OR YALI0C14344g OR YALI0F13937g OR YALI0F15983g OR YALI0F28765g | 1.2.1.2 |  |  | Methane metabolism | Flavin; Iron-sulfur; Molybdenum. |  |  |  | The enzyme from most aerobic organisms is devoid of redox-active centers but that from the proteobacterium [NAME] trichosporium contains iron-sulfur centers, flavin and a molybdenum center.Together with EC 1.12.1.2, forms a system previously known as formate hydrogenlyase. | IKU-IKReaction | n-1-1
R0401 | R00527 | S-Formylglutathione hydrolase | S-Formylglutathione hydrolase | S-Formylglutathione + H2O <=> Formate + Glutathione | C01031 + C00001 <=> C00058 + C00051 | irev | Forward | c | YALI0C20405g | 3.1.2.12 | hypothetical protein |  | Methane metabolism |  |  |  |  | Also hydrolyzes S-acetylglutathione, more slowly. | IKU-IKReaction | 1-1-1
R0402 | R00602 | methanol:hydrogen-peroxide oxidoreductase | methanol:hydrogen-peroxide oxidoreductase | Methanol + Hydrogen peroxide <=> Formaldehyde + 2 H2O | C00132 + C00027 <=> C00067 + 2 C00001 | irev | Forward | c | YALI0E34265g OR YALI0E34749g OR YALI0F30987g | 1.11.1.6 |  |  | Methane metabolism | Heme; Manganese. |  |  |  | This enzyme can also act as an EC 1.11.1.7 for which several organic substances, especially ethanol, can act as a hydrogen donor.A manganese protein containing [NAME]) in the resting state, which also belongs here, is often called pseudocatalase.Enzymes from some microorganisms, such as Penicillium simplicissimum, which exhibit both catalase and peroxidase activity, have sometimes been referred to as catalase-peroxidase. | IKU-IKUReaction | n-1-n
R0403 | R01011 | ATP:glycerone phosphotransferase | ATP:glycerone phosphotransferase | ATP + Glycerone <=> ADP + Glycerone phosphate | C00002 + C00184 <=> C00008 + C00111 | irev | Forward | c | YALI0F01606g OR YALI0F09273g | 2.7.1.29 |  |  | Methane metabolism |  |  |  |  |  | IKU-IKReaction | n-1-1
R0404 | R06983 | S-(hydroxymethyl)glutathione dehydrogenase | S-(hydroxymethyl)glutathione dehydrogenase | S-(Hydroxymethyl)glutathione + NAD+ <=> S-Formylglutathione + NADH + H+ | C14180 + C00003 <=> C01031 + C00004 + C00080 | irev | Forward | c | YALI0F09603g | 1.1.1.284 | hypothetical protein |  | Methane metabolism | Zinc (By similarity). |  | Unreviewed |  | The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22.Forms part of the pathway that detoxifies formaldehyde, since the product is hydrolyzed by EC 3.1.2.12.Also specifically reduces S-nitrosylglutathione.Formerly EC 1.2.1.1. | IKU-IKReaction | 1-n-n
R0405 | [NAME] | NO NAME | NO NAME | Tetrahydrofolate + Formaldehyde <=> 5,10-Methylenetetrahydrofolate | C00101 + C00067 <=> C00143 | irev | Forward | c |  |  |  |  | Methane metabolism |  |  |  |  | spontaneous reaction
R0414 | R00715 | [NAME]:NAD+ oxidoreductase (L-lysine-forming) | [NAME]:NAD+ oxidoreductase (L-lysine-forming) | [NAME] H2O <=> L-Lysine + 2-Oxoglutarate + NADH + H+ | C00449 + C00003 + C00001 <=> C00047 + C00026 + C00004 + C00080 | r |  | c | YALI0B15444g | 1.5.1.7 | saccharopine dehydrogenase (NAD+, L-lysine-forming) | Saccharopine dehydrogenase [NAD+, L-lysine-forming] | Lysine biosynthesis |  | Amino-acid biosynthesis L-lysine biosynthesis via AAA pathway L-lysine from L-alpha-aminoadipate (fungal route): step 3/3. | Reviewed |  |  | IKU-IKUReaction | 1-1-1
R0415 | R01934 | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating) | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating) | Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+ | C05662 + C00003 <=> C00322 + C00011 + C00004 + C00080 | r |  | m | YALI0D10593g | 1.1.1.87 | homoisocitrate dehydrogenase |  | Lysine biosynthesis |  |  |  |  | Forms part of the lysine biosynthesis pathway in fungi.Formerly EC 1.1.1.155. | IKU-IKReaction | 1-1-n
R0416 | R02315 | [NAME]:NADP+ oxidoreductase | [NAME]:NADP+ oxidoreductase | [NAME] H2O <=> L-Glutamate + L-2-Aminoadipate 6-semialdehyde + NADPH + H+ | C00449 + C00006 + C00001 <=> C00025 + C04076 + C00005 + C00080 | r |  | c | YALI0D22891g | 1.5.1.10 | saccharopine dehydrogenase (NADP+, L-glutamate forming) |  | Lysine biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0417 | R03444 + R04371 |  |  |  | C01251 <=> C05662 | r |  | m | YALI0E02728g | 4.2.1.36 | homoaconitase | Homoaconitase, mitochondrial | Lysine biosynthesis | Binds 1 4Fe-4S cluster per subunit (By similarity). | Amino-acid biosynthesis L-lysine biosynthesis via AAA pathway L-alpha-aminoadipate from 2-oxoglutarate: step 2/4. | Reviewed | Mitochondrion (By similarity). | The enzyme from the hyperthermophilic eubacterium [NAME] thermophilus can catalyze the reaction shown above but cannot catalyze the previously described reaction, i.e. formation of homocitrate by hydration of cis-homoaconitate.The enzyme responsible for the conversion of cis-homoaconitate into homocitrate in T.thermophilus is unknown at present but the reaction can be catalyzed in vitro using EC 4.2.1.3 from pig. | IKU-IKUReaction | 1-1-n
R0419 | R00271 | acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming) | acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming) | Acetyl-CoA + H2O + 2-Oxoglutarate <=> (R)-2-Hydroxybutane-1,2,4-tricarboxylate + CoA | C00024 + C00001 + C00026 <=> C01251 + C00010 | irev | Forward | m | YALI0F31075g | 2.3.3.14 | homocitrate synthase | Homocitrate synthase, mitochondrial | Lysine biosynthesis |  | Amino-acid biosynthesis L-lysine biosynthesis via AAA pathway L-alpha-aminoadipate from 2-oxoglutarate: step 1/4. | Reviewed | Mitochondrion. | Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36.Also acts with oxaloacetate as substrate, but more slowly.Formerly EC 4.1.3.21. | IKU-IKUReaction | 1-1-1
R0420 | R01939 | L-2-aminoadipate:2-oxoglutarate aminotransferase | L-2-aminoadipate:2-oxoglutarate aminotransferase | L-2-Aminoadipate + 2-Oxoglutarate <=> 2-Oxoadipate + L-Glutamate | C00956 + C00026 <=> C00322 + C00025 | r |  | c |  |  |  |  | Lysine biosynthesis
R0421 | R03102 | L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase | L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase | L-2-Aminoadipate 6-semialdehyde + NAD+ + H2O <=> L-2-Aminoadipate + NADH + H+ | C04076 + C00003 + C00001 <=> C00956 + C00004 + C00080 | r |  | c | [NAME] | 1.2.1.31 | aminoadipate-semialdehyde dehydrogenase precursor | L-aminoadipate-semialdehyde dehydrogenase | Lysine biosynthesis | Binds 1 phosphopantetheine covalently (By similarity). | Amino-acid biosynthesis L-lysine biosynthesis via AAA pathway L-lysine from L-alpha-aminoadipate (fungal route): step 1/3. | Unreviewed |  |  | IKU-IKUReaction | 1-1-n
R0422 | R03103 | L-2-Aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase | L-2-Aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase | L-2-Aminoadipate 6-semialdehyde + NADP+ + H2O <=> L-2-Aminoadipate + NADPH + H+ | C04076 + C00006 + C00001 <=> C00956 + C00005 + C00080 | r |  | c | [NAME] | 1.2.1.31 | aminoadipate-semialdehyde dehydrogenase precursor | L-aminoadipate-semialdehyde dehydrogenase | Lysine biosynthesis | Binds 1 phosphopantetheine covalently (By similarity). | Amino-acid biosynthesis L-lysine biosynthesis via AAA pathway L-lysine from L-alpha-aminoadipate (fungal route): step 1/3. | Unreviewed |  |  | IKU-IKUReaction | 1-1-n
R0423 | R02487 | Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) | Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) | Glutaryl-CoA + FAD <=> FADH2 + Crotonoyl-CoA + CO2 | C00527 + C00016 <=> C01352 + C00877 + C00011 | irev | Forward | m | [NAME] | 1.3.99.7 | hypothetical protein |  | Lysine degradation | FAD. |  |  |  |  | IKU-IKReaction | 1-1-n
R0424 | [NAME] | (S)-3-Hydroxybutanoyl-CoA hydro-lyase | (S)-3-Hydroxybutanoyl-CoA hydro-lyase | (S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O | C01144 <=> C00877 + C00001 | irev | Backward | m | YALI0B10406g | 4.2.1.17 | short chain enoyl-CoA hydratase |  | Lysine degradation |  |  |  |  | Acts in the reverse direction.With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74). | IKU-IKReaction | 1-1-n
R0428 | R01933 | 2-oxoadipate dehydrogenase complex | 2-oxoadipate dehydrogenase complex | 2-Oxoadipate + CoA + NAD+ <=> Glutaryl-CoA + CO2 + NADH + H+ | C00322 + C00010 + C00003 <=> C00527 + C00011 + C00004 + C00080 | irev | Forward | c | YALI0E33517g | 1.2.4.2 | 2-oxoglutarate dehydrogenase E1 component |  | Lysine degradation | Thiamine diphosphate. |  |  |  | It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, which also binds multiple copies of EC 1.8.1.4.It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61. | IKU-IKReaction | 1-1-n
R0430 |  | NADH:ubiquinone oxidoreductase | NADH:ubiquinone oxidoreductase | h + nadh + q6 --> nad + q6h2 |  | irev | Forward | m | (YALI0A20680g AND YALI0B00792g AND YALI0B14861g AND YALI0B20372g AND YALI0C03201g AND YALI0D00737g AND YALI0D04939g AND YALI0D05467g AND YALI0D07216g AND YALI0D14850g AND YALI0D19030g AND YALI0D24585g AND YALI0E23089g AND YALI0E31766g AND YALI0F00924g AND YALI0F02123g AND YALI0F06050g AND YALI0F17248g AND YALI0F18359g AND YALIfMp01 AND [NAME] AND YALIfMp16 AND YALIfMp19 AND YALIfMp20 AND [NAME] AND YALIfMp29) AND (YALI0A20680g AND YALI0B00792g AND YALI0B14861g AND YALI0B20372g AND YALI0C03201g AND YALI0D00737g AND YALI0D04939g AND YALI0D05467g AND YALI0D07216g AND YALI0D14850g AND YALI0D19030g AND YALI0D24585g AND YALI0E05599g AND YALI0E23089g AND YALI0E31766g AND YALI0F00924g AND YALI0F02123g AND YALI0F06050g AND YALI0F17248g AND YALI0F18359g AND YALI0F25135g) | 1.6.5.3 AND 1.6.99.3 |  |  | Oxidative phosphorylation |  |  |  |  | [m] : h + nadh + q6 --> nad + q6h2
R0431 |  | Ubiquinol:ferricytochrome-c oxidoreductase | Ubiquinol:ferricytochrome-c oxidoreductase | (2) ficytcc + (1.5) h + q6h2 --> (2) focytcc + (1.5) h + q6 |  | irev | Forward |  | YALI0A02915g | 1.10.2.2 |  |  | Oxidative phosphorylation |  |  |  |  | (2) ficytcc[m] + (1.5) h[m] + q6h2[m] --> (2) focytcc[m] + (1.5) h[c] + q6[m]
R0432 |  | NADH:ubiquinone oxidoreductase | NADH:ubiquinone oxidoreductase | h + nadh + q6 --> nad + q6h2 |  | irev | Forward |  | (YALI0A20680g AND YALI0B00792g AND YALI0B14861g AND YALI0B20372g AND YALI0C03201g AND YALI0D00737g AND YALI0D04939g AND YALI0D05467g AND YALI0D07216g AND YALI0D14850g AND YALI0D19030g AND YALI0D24585g AND YALI0E23089g AND YALI0E31766g AND YALI0F00924g AND YALI0F02123g AND YALI0F06050g AND YALI0F17248g AND YALI0F18359g AND YALIfMp01 AND [NAME] AND YALIfMp16 AND YALIfMp19 AND YALIfMp20 AND [NAME] AND YALIfMp29) AND (YALI0A20680g AND YALI0B00792g AND YALI0B14861g AND YALI0B20372g AND YALI0C03201g AND YALI0D00737g AND YALI0D04939g AND YALI0D05467g AND YALI0D07216g AND YALI0D14850g AND YALI0D19030g AND YALI0D24585g AND YALI0E05599g AND YALI0E23089g AND YALI0E31766g AND YALI0F00924g AND YALI0F02123g AND YALI0F06050g AND YALI0F17248g AND YALI0F18359g AND YALI0F25135g) | 1.6.5.3 AND 1.6.99.3 |  |  | Oxidative phosphorylation |  |  |  |  | h[c] + nadh[c] + q6[m] --> nad[c] + q6h2[m]
R0433 | R00081 | Ferrocytochrome-c:oxygen oxidoreductase | Ferrocytochrome-c:oxygen oxidoreductase | Oxygen + 4 Ferrocytochrome c + 4 H+ <=> 4 Ferricytochrome c + 2 H2O | C00007 + 4 C00126 + 4 C00080 <=> 4 C00125 + 2 C00001 | irev | Forward |  | YalifMp03 AND YalifMp05 AND YalifMp06 | 1.9.3.1 |  |  | Oxidative phosphorylation |  |  |  |  | (4) focytcc[m] + (6) h[m] + o2[m] --> (4) ficytcc[m] + (6) h[c] + (2) h2o[m]
R0434 | R00004 | diphosphate phosphohydrolase; pyrophosphate phosphohydrolase | diphosphate phosphohydrolase | Diphosphate + H2O <=> 2 Orthophosphate | C00013 + C00001 <=> 2 C00009 | irev | Forward | c | YALI0C11803g OR YALI0F13541g | 3.6.1.1 |  |  | Oxidative phosphorylation
R0435 | R00004 | diphosphate phosphohydrolase; pyrophosphate phosphohydrolase | diphosphate phosphohydrolase | Diphosphate + H2O <=> 2 Orthophosphate | C00013 + C00001 <=> 2 C00009 | irev | Forward | m | YALI0C11803g OR YALI0F13541g | 3.6.1.1 |  |  | Oxidative phosphorylation
R0436 |  | ATP phosphohydrolase | ATP phosphohydrolase | atp + h2o --> adp + h + pi |  | irev | Forward |  | YALI0B22066g | 3.6.3.6 |  |  | Oxidative phosphorylation |  |  |  |  | atp[c] + h2o[c] --> adp[c] + h[e] + pi[c]
R0437 |  | ATP phosphohydrolase | ATP phosphohydrolase | adp + (3) h + pi --> atp + (2) h + h2o |  | irev | Forward |  | [NAME] AND YALI0A11143g AND YALI0B03982g AND YALI0B06831g AND YALI0B21527g AND YALI0D00583g AND YALI0D11814g AND YALI0D12584g AND YALI0D17490g AND YALI0D22022g AND YALI0E08617g AND YALI0E09933g AND YALI0E11355g AND YALI0E16192g AND YALI0E27346g AND YALI0E31471g AND YALI0F02893g AND YALI0F03179g AND YALI0F04774g AND YALI0F09405g AND YALI0F15631g AND YALI0F16181g AND YALI0F20306g AND YALI0F24475g AND YALI0F31119g | 3.6.3.14 |  |  | Oxidative phosphorylation |  |  |  |  | adp[m] + (3) h[c] + pi[m] --> atp[m] + (2) h[m] + h2o[m]
R0438 | R00137 | ATP:nicotinamide-nucleotide adenylyltransferase | ATP:nicotinamide-nucleotide adenylyltransferase | ATP + Nicotinamide D-ribonucleotide <=> Diphosphate + NAD+ | C00002 + C00455 <=> C00013 + C00003 | irev | Forward | m | YALI0E25652g | 2.7.7.18 | hypothetical protein |  | Nicotinate and nicotinamide metabolism |  |  | Unreviewed |  |  | IKU-IKReaction | 1-n-n
R0439 | R00257 | Deamido-NAD+:L-glutamine amido-ligase (AMP-forming) | Deamido-NAD+:L-glutamine amido-ligase (AMP-forming) | ATP + Deamino-NAD+ + L-Glutamine + H2O <=> AMP + Diphosphate + NAD+ + L-Glutamate | C00002 + C00857 + C00064 + C00001 <=> C00020 + C00013 + C00003 + C00025 | irev | Forward | c | [NAME] | 6.3.5.1 | glutamine-dependent NAD(+)synthetase |  | Nicotinate and nicotinamide metabolism |  |  |  |  | NH(3) can act instead of glutamine (cf. EC 6.3.1.5). | IKU-IKReaction | 1-1-1
R0440 | R01268 | Nicotinamide amidohydrolase | Nicotinamide amidohydrolase | Nicotinamide + H2O <=> Nicotinate + NH3 | C00153 + C00001 <=> C00253 + C00014 | irev | Forward | c | YALI0A21153g | 3.5.1.19 | hypothetical protein |  | Nicotinate and nicotinamide metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0441 | R01724 | Nicotinate D-ribonucleotide:diphosphate phosphoribosyltransferase | Nicotinate D-ribonucleotide:diphosphate phosphoribosyltransferase | Nicotinate D-ribonucleotide + Diphosphate <=> Nicotinate + 5-Phospho-alpha-D-ribose 1-diphosphate | C01185 + C00013 <=> C00253 + C00119 | irev | Backward | c | YALI0B00220g | 2.4.2.11 | hypothetical protein | Nicotinate phosphoribosyltransferase | Nicotinate and nicotinamide metabolism |  | Cofactor biosynthesis NAD(+) biosynthesis nicotinate ribonucleotide from nicotinate: step 1/1. | Unreviewed |  |  | IKU-IKUReaction | 1-1-1
R0442 | R02294 | N-Ribosylnicotinamide:orthophosphate ribosyltransferase | N-Ribosylnicotinamide:orthophosphate ribosyltransferase | N-Ribosylnicotinamide + Orthophosphate <=> Nicotinamide + alpha-D-Ribose 1-phosphate | C03150 + C00009 <=> C00153 + C00620 | r |  | c | YALI0F30129g | 2.4.2.1 | hypothetical protein |  | Nicotinate and nicotinamide metabolism |  |  |  |  | Specificity not completely determined.Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5. | IKU-IKReaction | 1-1-n
R0443 | R02295 | Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase | Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase | Nicotinate D-ribonucleoside + Orthophosphate <=> Nicotinate + alpha-D-Ribose 1-phosphate + H+ | C05841 + C00009 <=> C00253 + C00620 + C00080 | r |  | c | YALI0F30129g | 2.4.2.1 | hypothetical protein |  | Nicotinate and nicotinamide metabolism |  |  |  |  | Specificity not completely determined.Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5. | IKU-IKReaction | 1-1-n
R0444 | R02323 | Nicotinamide ribonucleotide phosphohydrolase | Nicotinamide ribonucleotide phosphohydrolase | Nicotinamide D-ribonucleotide + H2O <=> N-Ribosylnicotinamide + Orthophosphate | C00455 + C00001 <=> C03150 + C00009 | irev | Forward | c | YALI0A08217g OR YALI0C19866g | 3.1.3.5 |  |  | Nicotinate and nicotinamide metabolism |  |  |  |  | Wide specificity for 5'-nucleotides. | IKU-IKReaction | n-1-n
R0445 | R03005 | ATP:nicotinamide-nucleotide adenylyltransferase | ATP:nicotinamide-nucleotide adenylyltransferase | ATP + Nicotinate D-ribonucleotide <=> Diphosphate + Deamino-NAD+ | C00002 + C01185 <=> C00013 + C00857 | irev | Forward | m | YALI0E25652g | 2.7.7.1 | hypothetical protein |  | Nicotinate and nicotinamide metabolism |  |  | Unreviewed |  |  | IKU-IKReaction | 1-n-n
R0446 | R03346 | Nicotinate D-ribonucleotide phosphohydrolase | Nicotinate D-ribonucleotide phosphohydrolase | Nicotinate D-ribonucleotide + H2O <=> Nicotinate D-ribonucleoside + Orthophosphate | C01185 + C00001 <=> C05841 + C00009 | r | Forward | c | YALI0A08217g OR YALI0C19866g | 3.1.3.5 |  |  | Nicotinate and nicotinamide metabolism |  |  |  |  | Wide specificity for 5'-nucleotides. | IKU-IKReaction | n-1-n
R0447 | R03348 | Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating) | Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating) | Nicotinate D-ribonucleotide + Diphosphate + CO2 <=> Quinolinate + 5-Phospho-alpha-D-ribose 1-diphosphate | C01185 + C00013 + C00011 <=> [NAME] | irev | Backward | c | YALI0E07073g | 2.4.2.19 | nicotinate-nucleotide pyrophosphorylase [carboxylating] |  | Nicotinate and nicotinamide metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0448 | R03347 | NO NAME | NO NAME | Nicotinate D-ribonucleotide + ADP <=> Nicotinate D-ribonucleoside + ATP | C01185 + C00008 <=> C05841 + C00002 | irev | Backward | c | YALI0B14729g | 2.7.1.22 |  |  | Nicotinate and nicotinamide metabolism
R0449 | [NAME] | ATP:N-ribosylnicotinamide 5'-phosphotransferase | ATP:N-ribosylnicotinamide 5'-phosphotransferase | ATP + N-Ribosylnicotinamide <=> ADP + Nicotinamide D-ribonucleotide | C00002 + C03150 <=> C00008 + C00455 | irev | Forward | c | YALI0B14729g | 2.7.1.22 |  |  | Nicotinate and nicotinamide metabolism
[NAME] |  | carbonate hydro-lyase (carbon-dioxide-forming); carbonic acid hydro-lyase | carbonic acid hydro-lyase | hco3 + H <=> CO2 + H2O | C00288 + C00080 <=> C00011 + C00001 | r |  | c | YALI0F21406g | 4.2.1.1 | hypothetical protein | Carbonic anhydrase | Nitrogen metabolism | Zinc. |  | Unreviewed |  |  | IKU-IKUReaction | 1-1-1
R0451 | R01221 | glycine synthase; glycine cleavage system | glycine synthase | Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NH3 + CO2 + NADH + H+ | C00037 + C00101 + C00003 <=> C00143 + C00014 + C00011 + C00004 + C00080 | irev | Backward | m | YALI0F02849g | 2.1.2.10 | aminomethyltransferase | Aminomethyltransferase | Nitrogen metabolism |  |  | Unreviewed |  | A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase.The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein. | IKU-IKUReaction | 1-1-n
R0452 | R00943 | Formate:tetrahydrofolate ligase (ADP-forming) | Formate:tetrahydrofolate ligase (ADP-forming) | Tetrahydrofolate + Formate + ATP <=> ADP + Orthophosphate + 10-Formyltetrahydrofolate | C00101 + C00058 + C00002 <=> C00008 + C00009 + C00234 | irev | Forward | c | YALI0E01056g OR YALI0F30745g | 6.3.4.3 |  |  | One carbon pool by folate |  |  |  |  | In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity. | IKU-IKReaction | n-n-n
R0453 | R01218 | 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase | 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase | 5,10-Methylenetetrahydrofolate + NAD+ <=> 5,10-Methenyltetrahydrofolate + NADH | C00143 + C00003 <=> C00445 + C00004 | r |  | c | YALI0B12078g | 1.5.1.15 | 5,10-methylenetetrahydrofolate dehydrogenase (NAD+) |  | One carbon pool by folate |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0454 | R01220 | 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase | 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase | 5,10-Methylenetetrahydrofolate + NADP+ <=> 5,10-Methenyltetrahydrofolate + NADPH | C00143 + C00006 <=> C00445 + C00005 | r |  | c | YALI0E01056g OR YALI0F30745g | 1.5.1.5 |  |  | One carbon pool by folate |  |  |  |  |  | IKU-IKReaction | n-n-n
R0455 | R01655 | 5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing) | 5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing) | 5,10-Methenyltetrahydrofolate + H2O <=> 10-Formyltetrahydrofolate + H+ | C00445 + C00001 <=> C00234 + C00080 | r |  | c | YALI0E01056g OR YALI0F30745g | 3.5.4.9 |  |  | One carbon pool by folate |  |  |  |  |  | IKU-IKReaction | n-n-n
R0456 | R02300 | S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) | S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) | 5-Formyltetrahydrofolate <=> 5,10-Methenyltetrahydrofolate + H2O | C03479 <=> C00445 + C00001 | irev | Backward | m | YALI0F02849g | 2.1.2.10 | aminomethyltransferase | Aminomethyltransferase | One carbon pool by folate |  |  | Unreviewed |  | A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase.The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein. | IKU-IKUReaction | 1-1-n
[NAME] | R02301 | 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) | 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) | ATP + 5-Formyltetrahydrofolate + H+ <=> ADP + Orthophosphate + 5,10-Methenyltetrahydrofolate | C00002 + C03479 + C00080 <=> C00008 + C00009 + C00445 | irev | Forward | c | YALI0D01309g | 6.3.3.2 | hypothetical protein |  | One carbon pool by folate |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0458 | R03940 | 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase | 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase | L-Methionyl-tRNA + 10-Formyltetrahydrofolate <=> Tetrahydrofolate + N-Formylmethionyl-tRNA | C02430 + C00234 <=> C00101 + C03294 | irev | Forward | m | YALI0F06820g | 2.1.2.9 | methionyl-tRNA formyltransferase |  | One carbon pool by folate |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0459 | R04326 | NO NAME | NO NAME | 5'-Phosphoribosylglycinamide + 5,10-Methenyltetrahydrofolate + H2O <=> 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolate | C03838 + C00445 + C00001 <=> C04376 + C00101 | irev | Forward | c | YALI0D03069g | 2.1.2.2 | hypothetical protein |  | One carbon pool by folate |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0460 | R07168 | 5-methyltetrahydrofolate:NAD+ oxidoreductase | 5-methyltetrahydrofolate:NAD+ oxidoreductase | 5-Methyltetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NADH + H+ | C00440 + C00003 <=> C00143 + C00004 + C00080 | irev | Backward | c | YALI0B00572g OR YALI0B14465g | 1.5.1.20 | hypothetical protein | Methylenetetrahydrofolate reductase | One carbon pool by folate | FAD | One-carbon metabolism tetrahydrofolate pathway. | Unreviewed |  | Menadione can also serve as an electron acceptor.Formerly EC 1.1.1.68, EC 1.1.1.171, EC 1.1.99.15 and EC 1.7.99.5. | IKU-IKUReaction | n-1-n
R0461 | R01224 | 5-methyltetrahydrofolate:NADP+ oxidoreductase | 5-methyltetrahydrofolate:NADP+ oxidoreductase | 5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+ | C00440 + C00006 <=> C00143 + C00005 + C00080 | irev | Backward | c | YALI0B00572g OR YALI0B14465g | 1.5.1.20 | hypothetical protein | Methylenetetrahydrofolate reductase | One carbon pool by folate | FAD | One-carbon metabolism tetrahydrofolate pathway. | Unreviewed |  | Menadione can also serve as an electron acceptor.Formerly EC 1.1.1.68, EC 1.1.1.171, EC 1.1.99.15 and EC 1.7.99.5. | IKU-IKUReaction | n-1-n
R0462 | [NAME] | Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating) | Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating) | Phenylpyruvate + Oxygen <=> 2-Hydroxyphenylacetate + CO2 | C00166 + C00007 <=> C05852 + C00011 | irev | Forward | c | YALI0B21846g | 1.13.11.27 | 4-hydroxyphenylpyruvate dioxygenase |  | Phenylalanine metabolism | Iron |  |  |  | Formerly EC 1.14.2.2 and EC 1.99.1.14 | IK-IKReaction | 1-1-n
R0463 | R02536 | [NAME]:NAD+ oxidoreductase | [NAME]:NAD+ oxidoreductase | [NAME] + NAD+ + H2O <=> Phenylacetic acid + NADH + H+ | C00601 + C00003 + C00001 <=> C07086 + C00004 + C00080 | r |  | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Phenylalanine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0464 | R02537 | [NAME]:NADP+ oxidoreductase | [NAME]:NADP+ oxidoreductase | [NAME] H2O <=> Phenylacetic acid + NADPH + H+ | C00601 + C00006 + C00001 <=> C07086 + C00005 + C00080 | r |  | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Phenylalanine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0465 | R02540 | 2-phenylacetamide amidohydrolase | 2-phenylacetamide amidohydrolase | 2-Phenylacetamide + H2O <=> Phenylacetic acid + NH3 | [NAME] <=> C07086 + C00014 | irev | Forward | c | YALI0E34771g OR YALI0F16401g | 3.5.1.4 |  |  | Phenylalanine metabolism |  |  |  |  |  | IKU-IU-noECnoReaction | n-1-n
R0466 | R02613 | Phenethylamine:oxygen oxidoreductase (deaminating) | Phenethylamine:oxygen oxidoreductase (deaminating) | [NAME] <=> Phenylacetaldehyde + NH3 + Hydrogen peroxide | C05332 + C00007 + C00001 <=> C00601 + C00014 + C00027 | r |  | c | YALI0C18315g OR YALI0C22792g | 1.4.3.21 |  |  | Phenylalanine metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0467 | [NAME] | NO NAME | NO NAME | Phenylacetic acid + Oxygen + NADH + H+ <=> 2-Hydroxyphenylacetate + NAD+ + H2O | C07086 + C00007 + C00004 + C00080 <=> C05852 + C00003 + C00001 | irev | Forward | c | YALI0F03663g | 1.14.13.- |  |  | Phenylalanine metabolism
R0468 | R00130 | ATP:dephospho-CoA 3'-phosphotransferase | ATP:dephospho-CoA 3'-phosphotransferase | ATP + 3-Dephospho-CoA <=> ADP + CoA | C00002 + C00882 <=> C00008 + C00010 | irev | Forward | c | [NAME] | 2.7.1.24 | dephospho-CoA kinase |  | Pantothenate and CoA biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0469 | R01226 | 5,10-Methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase | 5,10-Methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase | 5,10-Methylenetetrahydrofolate + 3-Methyl-2-oxobutanoic acid + H2O <=> Tetrahydrofolate + 2-Dehydropantoate | C00143 + C00141 + C00001 <=> C00101 + C00966 | irev | Forward | c | YALI0B18898g | 2.1.2.11 | ketopantoate hydroxymethyltransferase |  | Pantothenate and CoA biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0470 | R02472 | (R)-Pantoate:NADP+ 2-oxidoreductase | (R)-Pantoate:NADP+ 2-oxidoreductase | (R)-Pantoate + NADP+ <=> 2-Dehydropantoate + NADPH + H+ | C00522 + C00006 <=> C00966 + C00005 + C00080 | irev | Backward | c | YALI0F20900g | 1.1.1.169 | ketopantoate reductase |  | Pantothenate and CoA biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0471 | R02473 | (R)-Pantoate:beta-alanine ligase (AMP-forming) | (R)-Pantoate:beta-alanine ligase (AMP-forming) | ATP + (R)-Pantoate + beta-Alanine <=> AMP + Diphosphate + (R)-Pantothenate | C00002 + C00522 + C00099 <=> C00020 + C00013 + C00864 | irev | Forward | c | YALI0B06006g | 6.3.2.1 | pantothenate synthetase |  | Pantothenate and CoA biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0472 | R02971 | ATP:pantothenate 4'-phosphotransferase | ATP:pantothenate 4'-phosphotransferase | ATP + Pantetheine <=> ADP + Pantetheine 4'-phosphate | C00002 + C00831 <=> C00008 + C01134 | irev | Forward | c | YALI0D25476g | 2.7.1.33 | hypothetical protein |  | Pantothenate and CoA biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0473 | R03018 | ATP:pantothenate 4'-phosphotransferase | ATP:pantothenate 4'-phosphotransferase | ATP + Pantothenate <=> ADP + D-4'-Phosphopantothenate | C00002 + C00864 <=> C00008 + C03492 | irev | Forward | c | YALI0D25476g | 2.7.1.33 | hypothetical protein |  | Pantothenate and CoA biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0474 | [NAME] | ATP:pantetheine-4'-phosphate adenylyltransferase | ATP:pantetheine-4'-phosphate adenylyltransferase | ATP + Pantetheine 4'-phosphate <=> Diphosphate + Dephospho-CoA | C00002 + C01134 <=> C00013 + C00882 | r |  | c | YALI0D19426g | 2.7.7.3 | hypothetical protein |  | Pantothenate and CoA biosynthesis |  |  | Unreviewed |  | The enzyme from several bacteria (e.g. [NAME] coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157. | IKU-IU-noECnoReaction | 1-1-1
[NAME] | R03269 | N-[(R)-4'-Phosphopantothenoyl]-L-cysteine carboxy-lyase | N-[(R)-4'-Phosphopantothenoyl]-L-cysteine carboxy-lyase | (R)-4'-Phosphopantothenoyl-L-cysteine <=> Pantetheine 4'-phosphate + CO2 | C04352 <=> C01134 + C00011 | irev | Forward | c | YALI0E06413g | 4.1.1.36 | hypothetical protein |  | Pantothenate and CoA biosynthesis | FMN. |  | Unreviewed |  |  | IKU-IU-noECnoReaction | 1-1-1
R0476 | [NAME] | (R)-4'-Phosphopantothenate:L-cysteine ligase | (R)-4'-Phosphopantothenate:L-cysteine ligase | CTP + D-4'-Phosphopantothenate + L-Cysteine <=> CMP + Diphosphate + (R)-4'-Phosphopantothenoyl-L-cysteine | C00063 + C03492 + C00097 <=> C00055 + C00013 + C04352 | irev | Forward | c | YALI0C06996g | 6.3.2.5 | hypothetical protein |  | Pantothenate and CoA biosynthesis |  |  | Unreviewed |  | Cysteine can be replaced by some of its derivatives. | IKU-IU-noECnoReaction | 1-1-n
R0477 | R04391 | ATP:pantothenate 4'-phosphotransferase | ATP:pantothenate 4'-phosphotransferase | ATP + N-((R)-Pantothenoyl)-L-cysteine <=> ADP + (R)-4'-Phosphopantothenoyl-L-cysteine | C00002 + C04079 <=> C00008 + C04352 | irev | Forward | c | YALI0D25476g | 2.7.1.33 | hypothetical protein |  | Pantothenate and CoA biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-n
[NAME] | R00286 | UDP-glucose:NAD+ 6-oxidoreductase | UDP-glucose:NAD+ 6-oxidoreductase | UDP-glucose + H2O + 2 NAD+ <=> UDP-glucuronate + 2 NADH + 2 H+ | C00029 + C00001 + 2 C00003 <=> C00167 + 2 C00004 + 2 C00080 | r |  | c | YALI0D02321g | 1.1.1.22 | hypothetical protein |  | Pentose and glucuronate interconversions |  |  |  |  | Also acts on UDP-2-deoxyglucose. | IKU-IKReaction | 1-1-1
R0479 | R01639 | ATP:D-xylulose 5-phosphotransferase | ATP:D-xylulose 5-phosphotransferase | ATP + D-Xylulose <=> ADP + D-Xylulose 5-phosphate | C00002 + C00310 <=> C00008 + C00231 | irev | Forward | c | YALI0F10923g | 2.7.1.17 | xylulokinase |  | Pentose and glucuronate interconversions |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0481 | R01051 | ATP:D-ribose 5-phosphotransferase | ATP:D-ribose 5-phosphotransferase | ATP + D-Ribose <=> ADP + D-Ribose 5-phosphate | C00002 + C00121 <=> C00008 + C00117 | irev | Forward | c | YALI0B14927g | 2.7.1.15 | hypothetical protein |  | Pentose phosphate pathway |  |  |  |  | 2-deoxy-D-ribose can also act as acceptor. | IKU-IKReaction | 1-1-n
[NAME] | [NAME] | D-ribose-5-phosphate aldose-ketose-isomerase | D-ribose-5-phosphate aldose-ketose-isomerase | D-Ribose 5-phosphate <=> D-Ribulose 5-phosphate | C00117 <=> C00199 | r |  | c | YALI0B06941g OR YALI0F01628g | 5.3.1.6 |  |  | Pentose phosphate pathway |  |  |  |  | Also acts on D-ribose 5-diphosphate and D-ribose 5-triphosphate. | IKU-IKReaction | n-1-1
R0483 | R01528 | 6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating) | 6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating) | 6-Phospho-D-gluconate + NADP+ <=> D-Ribulose 5-phosphate + CO2 + NADPH + H+ | C00345 + C00006 <=> C00199 + C00011 + C00005 + C00080 | irev | Forward | c | YALI0B15598g | 1.1.1.44 | 6-phosphogluconate dehydrogenase (decarboxylating) | 6-phosphogluconate dehydrogenase, decarboxylating | Pentose phosphate pathway |  | Carbohydrate degradation pentose phosphate pathway D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. | Unreviewed |  |  | IKU-IKUReaction | 1-1-1
R0484 | R01529 | D-Ribulose-5-phosphate 3-epimerase | D-Ribulose-5-phosphate 3-epimerase | D-Ribulose 5-phosphate <=> D-Xylulose 5-phosphate | C00199 <=> C00231 | r |  | c | [NAME] | 5.1.3.1 | ribulose-5-phosphate 3-epimerase | Ribulose-phosphate 3-epimerase | Pentose phosphate pathway |  |  | Unreviewed |  | Also converts D-erythrose 4-phosphate into D-erythrulose 4-phosphate and D-threose 4-phosphate. | IKU-IKUReaction | 1-1-1
R0485 | [NAME] | Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase | Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase | Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Ribose 5-phosphate + D-Xylulose 5-phosphate | C05382 + C00118 <=> C00117 + C00231 | r |  | c | YALI0E06479g | 2.2.1.1 | transketolase |  | Pentose phosphate pathway | Thiamine diphosphate. |  |  |  | Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO(2) and R-CHOH-CO-CH(2)OH.Transketolase from Alcaligenes faecalis shows high activity with D-erythrose as acceptor. | IKU-IKReaction | 1-1-n
R0486 | R01737 | ATP:D-Gluconate 6-phosphotransferase | ATP:D-Gluconate 6-phosphotransferase | ATP + D-Gluconic acid <=> ADP + 6-Phospho-D-gluconate | C00002 + C00257 <=> C00008 + C00345 | irev | Forward | c | YALI0F07821g | 2.7.1.12 | gluconate kinase, SKI family |  | Pentose phosphate pathway |  |  |  |  |  | IKU-IKReaction | 1-1-1
[NAME] | R01827 | sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase | sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase | Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + beta-D-Fructose 6-phosphate | C05382 + C00118 <=> C00279 + C05345 | r |  | c | [NAME] | 2.2.1.2 | transaldolase | Transaldolase | Pentose phosphate pathway |  | Carbohydrate degradation pentose phosphate pathway D- glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D- ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. | Unreviewed |  |  | IKU-IKUReaction | 1-1-1
R0488 | R01830 | beta-D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase | beta-D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase | beta-D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + D-Xylulose 5-phosphate | C05345 + C00118 <=> C00279 + C00231 | r |  | c | YALI0E06479g | 2.2.1.1 | transketolase |  | Pentose phosphate pathway | Thiamine diphosphate. |  |  |  | Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO(2) and R-CHOH-CO-CH(2)OH.Transketolase from Alcaligenes faecalis shows high activity with D-erythrose as acceptor. | IKU-IKReaction | 1-1-n
R0489 | R02035 | 6-Phospho-D-glucono-1,5-lactone lactonohydrolase | 6-Phospho-D-glucono-1,5-lactone lactonohydrolase | D-Glucono-1,5-lactone 6-phosphate + H2O <=> 6-Phospho-D-gluconate | C01236 + C00001 <=> C00345 | irev | Forward | c | YALI0C19085g OR YALI0E11671g | 3.1.1.31 |  |  | Pentose phosphate pathway |  |  |  |  |  | IKU-IKReaction | n-1-1
R0490 | R02736 | beta-D-Glucose-6-phosphate:NADP+ 1-oxoreductase | beta-D-Glucose-6-phosphate:NADP+ 1-oxoreductase | beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+ | [NAME] + C00006 <=> C01236 + C00005 + C00080 | irev | Forward | c | YALI0E22649g | 1.1.1.49 | glucose-6-phosphate 1-dehydrogenase | Glucose-6-phosphate 1-dehydrogenase | Pentose phosphate pathway |  | Carbohydrate degradation pentose phosphate pathway. | Unreviewed |  | Also acts slowly on beta-D-glucose and other sugars.Certain preparations reduce NAD(+) as well as NADP(+). | IKU-IKUReaction | 1-1-1
R0492 | R01130 | IMP:NAD+ oxidoreductase | IMP:NAD+ oxidoreductase | IMP + NAD+ + H2O <=> Xanthosine 5'-phosphate + NADH + H+ | C00130 + C00003 + C00001 <=> C00655 + C00004 + C00080 | irev | Forward | c | YALI0D21530g | 1.1.1.205 | inosine-5'-monophosphate dehydrogenase | Inosine-5'-monophosphate dehydrogenase | Purine metabolism |  | Purine metabolism XMP biosynthesis via de novo pathway XMP from IMP: step 1/1. | Unreviewed |  | The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.Formerly EC 1.2.1.14. | IKU-IKUReaction | 1-1-1
R0493 | R02017 | 2'-Deoxyadenosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase | 2'-Deoxyadenosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase | dADP + Thioredoxin disulfide + H2O <=> [NAME] | C00206 + C00343 + C00001 <=> C00342 + C00008 | irev | Backward | c | YALI0B03630g AND YALI0D03333g AND YALI0F31735g | 1.17.4.1 |  |  | Purine metabolism | Iron. |  |  |  | Responsible for the de novo conversion of ribonucleoside diphosphates into deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair.While the enzyme is activated by ATP, it is inhibited by dATP. | IKU-IKReaction | n-1-n
R0494 | R02019 | 2'-Deoxyguanosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase | 2'-Deoxyguanosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase | dGDP + Thioredoxin disulfide + H2O <=> GDP + Thioredoxin | C00361 + C00343 + C00001 <=> C00035 + C00342 | irev | Backward | c | YALI0B03630g AND YALI0D03333g AND YALI0F31735g | 1.17.4.1 |  |  | Purine metabolism | Iron. |  |  |  | Responsible for the de novo conversion of ribonucleoside diphosphates into deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair.While the enzyme is activated by ATP, it is inhibited by dATP. | IKU-IKReaction | n-1-n
R0495 | R02106 | Urate:oxygen oxidoreductase | Urate:oxygen oxidoreductase | Urate + Oxygen + H2O <=> 5-Hydroxyisourate + Hydrogen peroxide | C00366 + C00007 + C00001 <=> C11821 + C00027 | irev | Forward | c | YALI0F09251g | 1.7.3.3 | hypothetical protein | Uricase | Purine metabolism |  | Purine metabolism urate degradation (S)-allantoin from urate: step 1/3. | Unreviewed | [NAME] (By similarity). | Was previously thought to be a copper protein, but it is now known that the enzymes from soybean (Glycine max), the mold Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion.The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO(2), although there is an enzyme-catalyzed pathway in which EC 3.5.2.17 catalyzes the first step.The enzyme is different from EC 1.14.13.113. | IKU-IKUReaction | 1-1-1
R0496 | R04325 | 10-Formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase | 10-Formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase | 10-Formyltetrahydrofolate + 5'-Phosphoribosylglycinamide <=> Tetrahydrofolate + 5'-Phosphoribosyl-N-formylglycinamide | C00234 + C03838 <=> C00101 + C04376 | irev | Forward | c | YALI0D03069g | 2.1.2.2 | hypothetical protein |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0497 | R04560 | 10-Formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase | 10-Formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase | 10-Formyltetrahydrofolate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide <=> Tetrahydrofolate + 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide | C00234 + C04677 <=> C00101 + C04734 | r |  | c | [NAME] | 2.1.2.3 | hypothetical protein |  | Purine metabolism |  |  | Unreviewed |  |  | IKU-IKReaction | 1-1-n
R0498 | [NAME] | IMP 1,2-hydrolase (decyclizing) | IMP 1,2-hydrolase (decyclizing) | IMP + H2O <=> 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide | C00130 + C00001 <=> C04734 | r |  | c | [NAME] | 3.5.4.10 | hypothetical protein |  | Purine metabolism |  |  | Unreviewed |  |  | IKU-IKReaction | 1-1-n
R0499 | R01561 | Adenosine:phosphate alpha-D-ribosyltransferase | Adenosine:phosphate alpha-D-ribosyltransferase | Adenosine + Orthophosphate <=> Adenine + alpha-D-Ribose 1-phosphate | C00212 + C00009 <=> C00147 + C00620 | r |  | c | YALI0F30129g | 2.4.2.1 | hypothetical protein |  | Purine metabolism |  |  |  |  | Specificity not completely determined.Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5. | IKU-IKReaction | 1-1-n
R0500 | R01863 | inosine:phosphate alpha-D-ribosyltransferase | inosine:phosphate alpha-D-ribosyltransferase | Inosine + Orthophosphate <=> Hypoxanthine + alpha-D-Ribose 1-phosphate | C00294 + C00009 <=> C00262 + C00620 | r |  | c | YALI0F30129g | 2.4.2.1 | hypothetical protein |  | Purine metabolism |  |  |  |  | Specificity not completely determined.Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5. | IKU-IKReaction | 1-1-n
R0501 | R01969 | Deoxyguanosine:orthophosphate ribosyltransferase | Deoxyguanosine:orthophosphate ribosyltransferase | Deoxyguanosine + Orthophosphate <=> Guanine + 2-Deoxy-D-ribose 1-phosphate | C00330 + C00009 <=> C00242 + C00672 | r |  | c | YALI0F30129g | 2.4.2.1 | hypothetical protein |  | Purine metabolism |  |  |  |  | Specificity not completely determined.Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5. | IKU-IKReaction | 1-1-n
R0502 | [NAME] | guanosine:phosphate alpha-D-ribosyltransferase | guanosine:phosphate alpha-D-ribosyltransferase | [NAME] <=> Guanine + alpha-D-Ribose 1-phosphate | C00387 + C00009 <=> C00242 + C00620 | r |  | c | YALI0F30129g | 2.4.2.1 | hypothetical protein |  | Purine metabolism |  |  |  |  | Specificity not completely determined.Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5. | IKU-IKReaction | 1-1-n
R0503 | R02297 | [NAME]:orthophosphate ribosyltransferase | [NAME]:orthophosphate ribosyltransferase | [NAME] <=> Xanthine + alpha-D-Ribose 1-phosphate | C01762 + C00009 <=> C00385 + C00620 | r |  | c | YALI0F30129g | 2.4.2.1 | hypothetical protein |  | Purine metabolism |  |  |  |  | Specificity not completely determined.Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5. | IKU-IKReaction | 1-1-n
R0504 | R02557 | [NAME]:orthophosphate ribosyltransferase | [NAME]:orthophosphate ribosyltransferase | [NAME] <=> Adenine + 2-Deoxy-D-ribose 1-phosphate | C00559 + C00009 <=> C00147 + C00672 | r |  | c | YALI0F30129g | 2.4.2.1 | hypothetical protein |  | Purine metabolism |  |  |  |  | Specificity not completely determined.Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5. | IKU-IKReaction | 1-1-n
R0505 | R02748 | Deoxyinosine:orthophosphate ribosyltransferase | Deoxyinosine:orthophosphate ribosyltransferase | Deoxyinosine + Orthophosphate <=> Hypoxanthine + 2-Deoxy-D-ribose 1-phosphate | C05512 + C00009 <=> C00262 + C00672 | r |  | c | YALI0F30129g | 2.4.2.1 | hypothetical protein |  | Purine metabolism |  |  |  |  | Specificity not completely determined.Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5. | IKU-IKReaction | 1-1-n
R0506 | R01072 | 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) | 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) | L-Glutamine + 5-Phospho-alpha-D-ribose 1-diphosphate + H2O <=> 5-Phosphoribosylamine + Diphosphate + L-Glutamate | C03090 + C00013 + C00025 <=> C00064 + C00119 + C00001 | irev | Backward | c | YALI0B15304g | 2.4.2.14 | amidophosphoribosyltransferase | Amidophosphoribosyltransferase | Purine metabolism | Binds 1 magnesium ion per subunit (By similarity). | Purine metabolism IMP biosynthesis via de novo pathway N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D- ribose 1-diphosphate: step 1/2. | Unreviewed |  |  | IKU-IKUReaction | 1-1-1
R0507 | [NAME] | AMP:diphosphate phospho-D-ribosyltransferase | AMP:diphosphate phospho-D-ribosyltransferase | AMP + Diphosphate <=> Adenine + 5-Phospho-alpha-D-ribose 1-diphosphate | C00020 + C00013 <=> [NAME] | irev | Backward | c | YALI0D05797g | 2.4.2.7 | adenine phosphoribosyltransferase | Adenine phosphoribosyltransferase | Purine metabolism | [NAME] (By similarity). | Purine metabolism AMP biosynthesis via salvage pathway AMP from adenine: step 1/1. | Reviewed | Cytoplasm (By similarity). [NAME] (By similarity). | 5-amino-4-imidazolecarboxamide can replace adenine. | IKU-IKUReaction | 1-1-n
R0508 | R01229 | GMP:diphosphate 5-phospho-alpha-D-ribosyltransferase | GMP:diphosphate 5-phospho-alpha-D-ribosyltransferase | GMP + Diphosphate <=> Guanine + 5-Phospho-alpha-D-ribose 1-diphosphate | C00144 + C00013 <=> C00242 + C00119 | irev | Backward | c | YALI0D05797g | 2.4.2.7 | adenine phosphoribosyltransferase | Adenine phosphoribosyltransferase | Purine metabolism | [NAME] (By similarity). | Purine metabolism AMP biosynthesis via salvage pathway AMP from adenine: step 1/1. | Reviewed | Cytoplasm (By similarity). [NAME] (By similarity). | 5-amino-4-imidazolecarboxamide can replace adenine. | IKU-IKUReaction | 1-1-n
R0509 | R04378 | 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide:pyrophosphate phosphoribosyltransferase | 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide:pyrophosphate phosphoribosyltransferase | 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + Diphosphate <=> 5-Amino-4-imidazolecarboxyamide + 5-Phospho-alpha-D-ribose 1-diphosphate | C04677 + C00013 <=> C04051 + C00119 | r |  | c | YALI0D05797g | 2.4.2.7 | adenine phosphoribosyltransferase | Adenine phosphoribosyltransferase | Purine metabolism | [NAME] (By similarity). | Purine metabolism AMP biosynthesis via salvage pathway AMP from adenine: step 1/1. | Reviewed | Cytoplasm (By similarity). [NAME] (By similarity). | 5-amino-4-imidazolecarboxamide can replace adenine. | IKU-IKUReaction | 1-1-n
R0510 | R00185 | ATP:adenosine 5'-phosphotransferase | ATP:adenosine 5'-phosphotransferase | ATP + Adenosine <=> ADP + AMP | C00002 + C00212 <=> C00008 + C00020 | r |  | c | YALI0F23463g | 2.7.1.20 | hypothetical protein |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0511 | R00127 | ATP:AMP phosphotransferase | ATP:AMP phosphotransferase | ATP + AMP <=> 2 ADP | C00002 + C00020 <=> 2 C00008 | r |  | c | YALI0B00704g | 2.7.4.3 | Adenylate kinase | Adenylate kinase 1 | Purine metabolism |  |  | Reviewed | Cytoplasm, cytosol (By similarity). Mitochondrion intermembrane space (By similarity). | Inorganic triphosphate can also act as donor. | IKU-IKReaction | n-1-n
R0512 | R01547 | ATP:dAMP phosphotransferase | ATP:dAMP phosphotransferase | ATP + dAMP <=> ADP + dADP | C00002 + C00360 <=> C00008 + C00206 | r |  | c | YALI0B00704g OR YALI0F26521g | 2.7.4.3 |  |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0513 | R00124 | ATP:ADP phosphatransferase | ATP:ADP phosphatransferase | ATP + ADP <=> ADP + ATP | C00002 + C00008 <=> C00008 + C00002 | r |  | c | YALI0F09229g | 2.7.4.6 | nucleoside diphosphate kinase | Nucleoside diphosphate kinase | Purine metabolism |  |  | Unreviewed |  | Many nucleoside diphosphates can act as acceptors.Many ribo- and deoxyribonucleoside triphosphates can act as donors. | IKU-IKUReaction | 1-1-n
R0514 | R00330 | ATP:GDP phosphotransferase | ATP:GDP phosphotransferase | ATP + GDP <=> ADP + GTP | C00002 + C00035 <=> C00008 + C00044 | r |  | c | YALI0F09229g | 2.7.4.6 | nucleoside diphosphate kinase | Nucleoside diphosphate kinase | Purine metabolism |  |  | Unreviewed |  | Many nucleoside diphosphates can act as acceptors.Many ribo- and deoxyribonucleoside triphosphates can act as donors. | IKU-IKUReaction | 1-1-n
R0515 | R00722 | ATP:IDP phosphotransferase | ATP:IDP phosphotransferase | ATP + IDP <=> ADP + ITP | C00002 + C00104 <=> C00008 + C00081 | r |  | c | YALI0F09229g | 2.7.4.6 | nucleoside diphosphate kinase | Nucleoside diphosphate kinase | Purine metabolism |  |  | Unreviewed |  | Many nucleoside diphosphates can act as acceptors.Many ribo- and deoxyribonucleoside triphosphates can act as donors. | IKU-IKUReaction | 1-1-n
R0516 | [NAME] | ATP:dADP phosphotransferase | ATP:dADP phosphotransferase | ATP + dADP <=> ADP + dATP | C00002 + C00206 <=> C00008 + C00131 | r |  | c | YALI0F09229g | 2.7.4.6 | nucleoside diphosphate kinase | Nucleoside diphosphate kinase | Purine metabolism |  |  | Unreviewed |  | Many nucleoside diphosphates can act as acceptors.Many ribo- and deoxyribonucleoside triphosphates can act as donors. | IKU-IKUReaction | 1-1-n
R0517 | R01857 | ATP:dGDP phosphotransferase | ATP:dGDP phosphotransferase | ATP + dGDP <=> ADP + dGTP | C00002 + C00361 <=> C00008 + C00286 | r |  | c | YALI0F09229g | 2.7.4.6 | nucleoside diphosphate kinase | Nucleoside diphosphate kinase | Purine metabolism |  |  | Unreviewed |  | Many nucleoside diphosphates can act as acceptors.Many ribo- and deoxyribonucleoside triphosphates can act as donors. | IKU-IKUReaction | 1-1-n
R0518 | R03530 | ATP:dIDP phosphotransferase | ATP:dIDP phosphotransferase | ATP + dIDP <=> ADP + dITP | C00002 + C01344 <=> C00008 + C01345 | r |  | c | YALI0F09229g | 2.7.4.6 | nucleoside diphosphate kinase | Nucleoside diphosphate kinase | Purine metabolism |  |  | Unreviewed |  | Many nucleoside diphosphates can act as acceptors.Many ribo- and deoxyribonucleoside triphosphates can act as donors. | IKU-IKUReaction | 1-1-n
R0519 | R00332 | ATP:GMP phosphotransferase | ATP:GMP phosphotransferase | ATP + GMP <=> ADP + GDP | C00002 + C00144 <=> C00008 + C00035 | r |  | c | YALI0C16434g | 2.7.4.8 | [NAME] |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0520 | R02090 | ATP:dGMP phosphotransferase | ATP:dGMP phosphotransferase | ATP + dGMP <=> ADP + dGDP | C00002 + C00362 <=> C00008 + C00361 | r |  | c | YALI0C16434g | 2.7.4.8 | [NAME] |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0521 | R01049 | ATP:D-ribose-5-phosphate diphosphotransferase | ATP:D-ribose-5-phosphate diphosphotransferase | ATP + D-Ribose 5-phosphate <=> AMP + 5-Phospho-alpha-D-ribose 1-diphosphate | C00002 + C00117 <=> C00020 + C00119 | r |  | c | YALI0B00836g OR YALI0B13552g OR YALI0E32351g OR YALI0F25047g | 2.7.6.1 | hypothetical protein | Ribose-phosphate pyrophosphokinase | Purine metabolism |  |  | Unreviewed |  | dATP can also act as donor. | IKU-IKUReaction | n-1-1
R0526 | R00183 | Adenosine 5'-monophosphate phosphohydrolase | Adenosine 5'-monophosphate phosphohydrolase | AMP + H2O <=> Adenosine + Orthophosphate | C00020 + C00001 <=> C00212 + C00009 | irev | Forward | c | YALI0A08217g OR YALI0C19866g | 3.1.3.5 |  |  | Purine metabolism |  |  |  |  | Wide specificity for 5'-nucleotides. | IKU-IKReaction | n-1-n
R0527 | R01126 | Inosine 5'-monophosphate phosphohydrolase | Inosine 5'-monophosphate phosphohydrolase | IMP + H2O <=> Inosine + Orthophosphate | C00130 + C00001 <=> C00294 + C00009 | irev | Forward | c | YALI0A08217g OR YALI0C19866g | 3.1.3.5 |  |  | Purine metabolism |  |  |  |  | Wide specificity for 5'-nucleotides. | IKU-IKReaction | n-1-n
[NAME] | [NAME] | [NAME] 5'-monophosphate phosphohydrolase | [NAME] 5'-monophosphate phosphohydrolase | GMP + H2O <=> [NAME] | C00144 + C00001 <=> C00387 + C00009 | irev | Forward | c | YALI0A08217g OR YALI0C19866g | 3.1.3.5 |  |  | Purine metabolism |  |  |  |  | Wide specificity for 5'-nucleotides. | IKU-IKReaction | n-1-n
R0529 | R01968 | 2'-Deoxyguanosine 5'-monophosphate phosphohydrolase | 2'-Deoxyguanosine 5'-monophosphate phosphohydrolase | dGMP + H2O <=> Deoxyguanosine + Orthophosphate | C00362 + C00001 <=> C00330 + C00009 | irev | Forward | c | YALI0A08217g OR YALI0C19866g | 3.1.3.5 |  |  | Purine metabolism |  |  |  |  | Wide specificity for 5'-nucleotides. | IKU-IKReaction | n-1-n
[NAME] | R02088 | 2'-Deoxyadenosine 5'-monophosphate phosphohydrolase | 2'-Deoxyadenosine 5'-monophosphate phosphohydrolase | dAMP + H2O <=> Deoxyadenosine + Orthophosphate | C00360 + C00001 <=> C00559 + C00009 | r |  | c | YALI0A08217g OR YALI0C19866g | 3.1.3.5 |  |  | Purine metabolism |  |  |  |  | Wide specificity for 5'-nucleotides. | IKU-IKReaction | n-1-n
R0531 | R02719 | Xanthosine 5'-phosphate phosphohydrolase | Xanthosine 5'-phosphate phosphohydrolase | Xanthosine 5'-phosphate + H2O <=> Xanthosine + Orthophosphate | C00655 + C00001 <=> C01762 + C00009 | irev | Forward | c | YALI0A08217g OR YALI0C19866g | 3.1.3.5 |  |  | Purine metabolism |  |  |  |  | Wide specificity for 5'-nucleotides. | IKU-IKReaction | n-1-n
R0532 | R00191 | adenosine 3',5'-phosphate 5'-nucleotidohydrolase | adenosine 3',5'-phosphate 5'-nucleotidohydrolase | 3',5'-Cyclic AMP + H2O <=> AMP | C00575 + C00001 <=> C00020 | irev | Forward | c | YALI0A08041g OR YALI0E32527g | 3.1.4.17 |  |  | Purine metabolism |  |  |  |  | Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP. | IKU-IKReaction | n-1-n
R0533 | [NAME] | [NAME] 5'-nucleotidohydrolase | [NAME] 5'-nucleotidohydrolase | 3',5'-Cyclic GMP + H2O <=> GMP | C00942 + C00001 <=> C00144 | irev | Forward | c | YALI0A08041g OR YALI0E32527g | 3.1.4.17 |  |  | Purine metabolism |  |  |  |  | Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP. | IKU-IKReaction | n-1-n
R0534 | R06601 | 5-hydroxyisourate amidohydrolase | 5-hydroxyisourate amidohydrolase | 5-Hydroxyisourate + H2O <=> 5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate | C11821 + C00001 <=> C12248 | irev | Forward | c | YALI0F22605g | 3.5.2.17 | hypothetical protein |  | Purine metabolism |  |  |  |  | The reaction is the first stage in the conversion of 5-hydroxyisourate into (S)-allantoin.This reaction will also occur spontaneously, but more slowly. | IKU-IKReaction | 1-1-1
R0535 | R02425 | (S)(+)-Allantoin amidohydrolase | (S)(+)-Allantoin amidohydrolase | (S)(+)-Allantoin + H2O <=> Allantoate | C02350 + C00001 <=> C00499 | r |  | c | YALI0F23243g | 3.5.2.5 | hypothetical protein |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0536 | R00469 | (S)-ureidoglycolate amidohydrolase (decarboxylating) | (S)-ureidoglycolate amidohydrolase (decarboxylating) | (S)-Ureidoglycolate + H2O <=> Glyoxylate + 2 NH3 + CO2 | C00603 + C00001 <=> C00048 + 2 C00014 + C00011 | r |  | c | YALI0F06710g | 3.5.3.19 | hypothetical protein |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0537 | R02422 | Allantoate amidinohydrolase | Allantoate amidinohydrolase | Allantoate + H2O <=> (S)-Ureidoglycolate + Urea | C00499 + C00001 <=> C00603 + C00086 | r |  | c | YALI0D18337g | 3.5.3.4 | hypothetical protein |  | Purine metabolism |  |  |  |  | Also hydrolyzes (R)-ureidoglycolate to glyoxylate and urea. | IKU-IKReaction | 1-1-1
R0538 | R01676 | Guanine aminohydrolase | Guanine aminohydrolase | Guanine + H2O <=> Xanthine + NH3 | C00242 + C00001 <=> C00385 + C00014 | irev | Forward | c | YALI0E25740g | 3.5.4.3 | guanine deaminase |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0539 | R00181 | AMP aminohydrolase | AMP aminohydrolase | AMP + H2O <=> IMP + NH3 | C00020 + C00001 <=> C00130 + C00014 | irev | Forward | c | YALI0E11495g | 3.5.4.6 | hypothetical protein |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0540 | R01054 | ADP-ribose ribophosphohydrolase | ADP-ribose ribophosphohydrolase | ADP-ribose + H2O <=> AMP + D-Ribose 5-phosphate | C00301 + C00001 <=> C00020 + C00117 | irev | Forward | c | YALI0F26125g | 3.6.1.13 | hypothetical protein |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0542 | R00086 | ATP phosphohydrolase | ATP phosphohydrolase | ATP + H2O <=> ADP + Orthophosphate | C00002 + C00001 <=> C00008 + C00009 | irev | Forward | c | YALI0C19712g | 3.6.1.5 | hypothetical protein |  | Purine metabolism | Calcium. |  |  |  | Also acts on ADP, and on other nucleoside triphosphates and diphosphates.Most of the ecto-ATPases occurring on the cell surface and hydrolyzing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. | IKU-IKReaction | 1-1-n
R0543 | R00122 | ADP phosphohydrolase | ADP phosphohydrolase | ADP + H2O <=> AMP + Orthophosphate | C00008 + C00001 <=> C00020 + C00009 | irev | Forward | c | YALI0C19712g | 3.6.1.5 | hypothetical protein |  | Purine metabolism | Calcium. |  |  |  | Also acts on ADP, and on other nucleoside triphosphates and diphosphates.Most of the ecto-ATPases occurring on the cell surface and hydrolyzing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. | IKU-IKReaction | 1-1-n
R0544 | R00328 | GDP phosphohydrolase | GDP phosphohydrolase | GDP + H2O <=> GMP + Orthophosphate | C00035 + C00001 <=> C00144 + C00009 | irev | Forward | c | YALI0C19712g | 3.6.1.5 | hypothetical protein |  | Purine metabolism | Calcium. |  |  |  | Also acts on ADP, and on other nucleoside triphosphates and diphosphates.Most of the ecto-ATPases occurring on the cell surface and hydrolyzing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. | IKU-IKReaction | 1-1-n
R0545 | R00335 | GTP phosphohydrolase | GTP phosphohydrolase | GTP + H2O <=> GDP + Orthophosphate | C00044 + C00001 <=> C00035 + C00009 | irev | Forward | c | YALI0C19712g | 3.6.1.5 | hypothetical protein |  | Purine metabolism | Calcium. |  |  |  | Also acts on ADP, and on other nucleoside triphosphates and diphosphates.Most of the ecto-ATPases occurring on the cell surface and hydrolyzing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. | IKU-IKReaction | 1-1-n
R0546 | R00719 | ITP phosphohydrolase | ITP phosphohydrolase | ITP + H2O <=> IDP + Orthophosphate | C00081 + C00001 <=> C00104 + C00009 | irev | Forward | c | YALI0C19712g | 3.6.1.5 | hypothetical protein |  | Purine metabolism | Calcium. |  |  |  | Also acts on ADP, and on other nucleoside triphosphates and diphosphates.Most of the ecto-ATPases occurring on the cell surface and hydrolyzing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. | IKU-IKReaction | 1-1-n
R0547 | R00961 | IDP phosphohydrolase | IDP phosphohydrolase | IDP + H2O <=> IMP + Orthophosphate | C00104 + C00001 <=> C00130 + C00009 | irev | Forward | c | YALI0C19712g | 3.6.1.5 | hypothetical protein |  | Purine metabolism | Calcium. |  |  |  | Also acts on ADP, and on other nucleoside triphosphates and diphosphates.Most of the ecto-ATPases occurring on the cell surface and hydrolyzing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. | IKU-IKReaction | 1-1-n
R0548 | R04209 | 1-(5-phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase | 1-(5-phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase | 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate <=> Aminoimidazole ribotide + CO2 | C04751 <=> C03373 + C00011 | r |  | c | YALI0B23188g | 4.1.1.21 | phosphoribosylaminoimidazole carboxylase |  | Purine metabolism |  |  |  |  | While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18 and EC 5.4.99.18.5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate. | IKU-IKReaction | 1-1-1
R0549 | R04559 | 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase | 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase | 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole <=> Fumarate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide | C04823 <=> C00122 + C04677 | r |  | c | YALI0B17402g | 4.3.2.2 | hypothetical protein |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0550 | R00089 | ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) | ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) | ATP <=> 3',5'-Cyclic AMP + Diphosphate | C00002 <=> C00575 + C00013 | irev | Forward | c | YALI0B18759g | 4.6.1.1 | hypothetical protein |  | Purine metabolism |  |  |  |  | Also acts on dATP to form 3',5'-cyclic dAMP.Requires pyruvate.Activated by NAD(+) in presence of EC 2.4.2.31. | IKU-IKReaction | 1-1-n
R0551 | R00434 | GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) | GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) | GTP <=> 3',5'-Cyclic GMP + Diphosphate | C00044 <=> C00942 + C00013 | irev | Forward | c | YALI0B18759g | 4.6.1.1 | hypothetical protein |  | Purine metabolism |  |  |  |  | Also acts on dATP to form 3',5'-cyclic dAMP.Requires pyruvate.Activated by NAD(+) in presence of EC 2.4.2.31. | IKU-IKReaction | 1-1-n
R0552 | R01057 | D-Ribose 1,5-phosphomutase | D-Ribose 1,5-phosphomutase | alpha-D-Ribose 1-phosphate <=> D-Ribose 5-phosphate | C00620 <=> C00117 | r |  | c | YALI0E02090g OR YALI0E02244g | 5.4.2.2 |  |  | Purine metabolism |  |  |  |  | Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate.This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization.Also, more slowly, catalyzes the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate.Formerly EC 2.7.5.1. | IKU-IKReaction | n-1-n
R0553 | R04591 | 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming) | 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming) | ATP + 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate + L-Aspartate <=> ADP + Orthophosphate + 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole | C00002 + C04751 + C00049 <=> C00008 + C00009 + C04823 | r |  | c | YALI0E33033g | 6.3.2.6 | phosphoribosylaminoimidazole-succinocarboxamide synthase | Phosphoribosylaminoimidazole-succinocarboxamide synthase | Purine metabolism |  | Purine metabolism IMP biosynthesis via de novo pathway 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. | Unreviewed |  | Forms part of the purine biosynthesis pathway. | IKU-IKUReaction | 1-1-1
R0554 | R04208 | 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) | 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) | ATP + 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine <=> ADP + Orthophosphate + Aminoimidazole ribotide | C00002 + C04640 <=> C00008 + C00009 + C03373 | irev | Forward | c | YALI0F21010g | 6.3.3.1 | phosphoribosylamine--glycine ligase | Phosphoribosylformylglycinamidine cyclo-ligase | Purine metabolism |  | Purine metabolism IMP biosynthesis via de novo pathway N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D- ribose 1-diphosphate: step 2/2. | Reviewed |  |  | IKU-IKReaction | 1-n-n
R0555 | R04144 | 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming) | 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming) | ATP + 5-Phosphoribosylamine + Glycine <=> ADP + Orthophosphate + 5'-Phosphoribosylglycinamide | C00002 + C03090 + C00037 <=> C00008 + C00009 + C03838 | irev | Forward | c | YALI0F21010g | 6.3.4.13 | phosphoribosylamine--glycine ligase | Phosphoribosylformylglycinamidine cyclo-ligase | Purine metabolism |  | Purine metabolism IMP biosynthesis via de novo pathway N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D- ribose 1-diphosphate: step 2/2. | Reviewed |  | Formerly EC 6.3.1.3. | IKU-IKReaction | 1-n-n
R0556 | R01231 | Xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming) | Xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming) | ATP + Xanthosine 5'-phosphate + L-Glutamine + H2O <=> AMP + Diphosphate + GMP + L-Glutamate | C00002 + C00655 + C00064 + C00001 <=> C00020 + C00013 + C00144 + C00025 | irev | Forward | c | YALI0B16104g | 6.3.5.2 | GMP synthase (glutamine-hydrolyzing) | GMP synthase [glutamine-hydrolyzing] | Purine metabolism |  | Purine metabolism GMP biosynthesis GMP from XMP (L-Gln route): step 1/1. | Reviewed | Cytoplasm (By similarity). |  | IKU-IKUReaction | 1-1-1
R0557 | R04463 | 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming) | 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming) | ATP + 5'-Phosphoribosyl-N-formylglycinamide + L-Glutamine + H2O <=> ADP + Orthophosphate + 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine + L-Glutamate | C00002 + C04376 + C00064 + C00001 <=> C00008 + C00009 + C04640 + C00025 | irev | Forward | c | YALI0F30019g | 6.3.5.3 | phosphoribosylformylglycinamidine synthase |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0558 | R01083 | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) | N6-(1,2-Dicarboxyethyl)-AMP <=> Fumarate + AMP | C03794 <=> C00122 + C00020 | r |  | c | YALI0B17402g | 4.3.2.2 | hypothetical protein |  | Purine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0559 | R01135 | IMP:L-aspartate ligase (GDP-forming) | IMP:L-aspartate ligase (GDP-forming) | GTP + IMP + L-Aspartate <=> GDP + Orthophosphate + N6-(1,2-Dicarboxyethyl)-AMP | C00044 + C00130 + C00049 <=> C00035 + C00009 + C03794 | irev | Forward | c | YALI0E28963g | 6.3.4.4 | Adenylosuccinate synthetase |  | Purine metabolism | Zinc. |  |  |  |  | IK-IKReaction | 1-1-1
R0561 | R00694 | L-Phenylalanine:2-oxoglutarate aminotransferase | L-Phenylalanine:2-oxoglutarate aminotransferase | L-Phenylalanine + 2-Oxoglutarate <=> Phenylpyruvate + L-Glutamate | C00079 + C00026 <=> C00166 + C00025 | r |  | c | YALI0E20977g | 2.6.1.5 |  |  | Phenylalanine, tyrosine and tryptophan biosynthesis |  |  |  |  |  | IKU-differenceReaction OR IKU-IKReaction OR IKU-IKUReaction | 1-n-n OR 1-1-n OR n-1-n
R0562 | [NAME] | L-tyrosine:2-oxoglutarate aminotransferase | L-tyrosine:2-oxoglutarate aminotransferase | L-Tyrosine + 2-Oxoglutarate <=> 3-(4-Hydroxyphenyl)pyruvate + L-Glutamate | C00082 + C00026 <=> C01179 + C00025 | r |  | c | YALI0E20977g | 2.6.1.5 |  |  | Phenylalanine, tyrosine and tryptophan biosynthesis |  |  |  |  |  | IKU-differenceReaction OR IKU-IKReaction OR IKU-IKUReaction | 1-n-n OR 1-1-n OR n-1-n
R0563 | R00986 | Chorismate pyruvate-lyase (amino-accepting) | Chorismate pyruvate-lyase (amino-accepting) | Chorismate + L-Glutamine <=> Anthranilate + Pyruvate + L-Glutamate | C00251 + C00064 <=> C00108 + C00022 + C00025 | irev | Forward | c | [NAME]g | 4.1.3.27 |  |  | Phenylalanine, tyrosine and tryptophan biosynthesis |  |  |  |  | In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.1.48, EC 4.2.1.20, and EC 5.3.1.24).The native enzyme in the complex with uses either glutamine or (less efficiently) NH(3).The enzyme separated from the complex uses NH(3) only. | IKU-IKReaction | n-1-n
R0564 | R01073 | N-(5-Phospho-D-ribosyl)anthranilate:pyrophosphate phosphoribosyl-transferase | N-(5-Phospho-D-ribosyl)anthranilate:pyrophosphate phosphoribosyl-transferase | N-(5-Phospho-D-ribosyl)anthranilate + Diphosphate <=> Anthranilate + 5-Phospho-alpha-D-ribose 1-diphosphate | C04302 + C00013 <=> C00108 + C00119 | r |  | c | YALI0D27170g | 2.4.2.18 | anthranilate phosphoribosyltransferase |  | Phenylalanine, tyrosine and tryptophan biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0565 | R01373 | prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming) | prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming) | Prephenate <=> Phenylpyruvate + H2O + CO2 | C00254 <=> C00166 + C00001 + C00011 | r |  | c | YALI0B17336g | 4.2.1.51 | prephenate dehydratase |  | Phenylalanine, tyrosine and tryptophan biosynthesis |  |  | Unreviewed |  | This enzyme in the enteric bacteria also possesses EC 5.4.99.5 activity and converts chorismate into prephenate. | IKU-differenceReaction | 1-1-n
R0566 | [NAME] | 5-O-(1-Carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming) | 5-O-(1-Carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming) | 5-O-(1-Carboxyvinyl)-3-phosphoshikimate <=> Chorismate + Orthophosphate | C01269 <=> C00251 + C00009 | irev | Forward | c | YALI0D17930g | 4.2.3.5 | chorismate synthase | Chorismate synthase | Phenylalanine, tyrosine and tryptophan biosynthesis | FMN | Metabolic intermediate biosynthesis chorismate biosynthesis chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. | Unreviewed |  | The reaction goes via a radical mechanism that involves reduced FMN and its semiquinone (FMNH.).Shikimate is numbered so that the double-bond is between C-1 and C-2, but some earlier papers numbered the ring in the reverse direction.Formerly EC 4.6.1.4. | IKU-IKUReaction | 1-1-1
R0567 | R01715 | Chorismate pyruvatemutase | Chorismate pyruvatemutase | Chorismate <=> Prephenate | C00251 <=> C00254 | r |  | c | YALI0B17336g OR YALI0E17479g | 5.4.99.5 |  |  | Phenylalanine, tyrosine and tryptophan biosynthesis |  |  |  |  |  | IKU-IKReaction | n-1-1
R0568 | R01730 | Prephenate:NADP+ oxidoreductase(decarboxylating) | Prephenate:NADP+ oxidoreductase(decarboxylating) | Prephenate + NADP+ <=> 3-(4-Hydroxyphenyl)pyruvate + CO2 + NADPH + H+ | C00254 + C00006 <=> C01179 + C00011 + C00005 + C00080 | irev | Forward | c | YALI0F17644g | 1.3.1.13 | prephenate dehydrogenase |  | Phenylalanine, tyrosine and tryptophan biosynthesis |  |  | Unreviewed |  |  | IKU-differenceReaction | 1-1-1
R0569 | R01826 | Phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate hydrolysing, 2-carboxy-2-oxoethyl-forming) | Phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate hydrolysing, 2-carboxy-2-oxoethyl-forming) | Phosphoenolpyruvate + D-Erythrose 4-phosphate + H2O <=> 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + Orthophosphate | C00074 + C00279 + C00001 <=> C04691 + C00009 | irev | Forward | c | YALI0B20020g OR YALI0B22440g OR YALI0C06952g | 2.5.1.54 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase | Phospho-2-dehydro-3-deoxyheptonate aldolase | Phenylalanine, tyrosine and tryptophan biosynthesis |  | Metabolic intermediate biosynthesis chorismate biosynthesis chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7. | Unreviewed |  | Formerly EC 4.1.2.15. | IKU-IKReaction | n-1-1
R0570 | R02412 | ATP:shikimate 3-phosphotransferase | ATP:shikimate 3-phosphotransferase | ATP + Shikimate <=> ADP + Shikimate 3-phosphate | C00002 + C00493 <=> C00008 + C03175 | irev | Forward | c | YALI0F12639g | 2.7.1.71 | 3-dehydroquinate synthase | Shikimate dehydrogenase | Phenylalanine, tyrosine and tryptophan biosynthesis | Binds 2 zinc ions per subunit. | Metabolic intermediate biosynthesis chorismate biosynthesis chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. | Reviewed | Cytoplasm (By similarity). |  | IKU-IKReaction | 1-n-n
R0571 | R02413 | Shikimate:NADP+ 3-oxidoreductase | Shikimate:NADP+ 3-oxidoreductase | Shikimate + NADP+ <=> 3-Dehydroshikimate + NADPH + H+ | C00493 + C00006 <=> C02637 + C00005 + C00080 | irev | Backward | c | YALI0F12639g | 1.1.1.25 | 3-dehydroquinate synthase | Shikimate dehydrogenase | Phenylalanine, tyrosine and tryptophan biosynthesis | Binds 2 zinc ions per subunit. | Metabolic intermediate biosynthesis chorismate biosynthesis chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. | Reviewed | Cytoplasm (By similarity). | NAD(+) cannot replace NADP(+).In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10. | IKU-IKReaction | 1-n-n
R0572 | [NAME] | 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate phosphate-lyase (cyclyzing) | 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate phosphate-lyase (cyclyzing) | 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate <=> 3-Dehydroquinate + Orthophosphate | C04691 <=> C00944 + C00009 | irev | Forward | c | YALI0F12639g | 4.2.3.4 | 3-dehydroquinate synthase | Shikimate dehydrogenase | Phenylalanine, tyrosine and tryptophan biosynthesis | Binds 2 zinc ions per subunit. | Metabolic intermediate biosynthesis chorismate biosynthesis chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. | Reviewed | Cytoplasm (By similarity). | The hydrogen atoms on C-7 of the substrate are retained on C-2 of the products.Formerly EC 4.6.1.3. | IKU-IKReaction | 1-n-n
R0573 | R03084 | 3-Dehydroquinate hydro-lyase | 3-Dehydroquinate hydro-lyase | 3-Dehydroquinate <=> 3-Dehydroshikimate + H2O | C00944 <=> C02637 + C00001 | r |  | c | YALI0F12639g | 4.2.1.10 | 3-dehydroquinate synthase | Shikimate dehydrogenase | Phenylalanine, tyrosine and tryptophan biosynthesis | Binds 2 zinc ions per subunit. | Metabolic intermediate biosynthesis chorismate biosynthesis chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. | Reviewed | Cytoplasm (By similarity). |  | IKU-IKReaction | 1-n-n
R0574 | R03460 | Phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase | Phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase | Phosphoenolpyruvate + Shikimate 3-phosphate <=> Orthophosphate + 5-O-(1-Carboxyvinyl)-3-phosphoshikimate | C00074 + C03175 <=> C00009 + C01269 | r |  | c | YALI0F12639g | 2.5.1.19 | 3-dehydroquinate synthase | Shikimate dehydrogenase | Phenylalanine, tyrosine and tryptophan biosynthesis | Binds 2 zinc ions per subunit. | Metabolic intermediate biosynthesis chorismate biosynthesis chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. | Reviewed | Cytoplasm (By similarity). |  | IKU-IKReaction | 1-n-n
R0575 | R03508 | 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase(cyclizing) | 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase(cyclizing) | 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate <=> Indoleglycerol phosphate + CO2 + H2O | C01302 <=> C03506 + C00011 + C00001 | r |  | c | [NAME] | 4.1.1.48 | indole-3-glycerol phosphate synthase |  | Phenylalanine, tyrosine and tryptophan biosynthesis |  |  |  |  | In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20, and EC 5.3.1.24). | IKU-IKReaction | n-1-n
[NAME] | R02722 | L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming] | L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming] | L-Serine + Indoleglycerol phosphate <=> L-Tryptophan + D-Glyceraldehyde 3-phosphate + H2O | C00065 + C03506 <=> C00078 + C00118 + C00001 | irev | Forward | c | YALI0F24893g | 4.2.1.20 | tryptophan synthase, alpha chain |  | Phenylalanine, tyrosine and tryptophan biosynthesis | Pyridoxal 5'-phosphate. |  |  |  | The alpha-subunit catalyzes the conversion of 1-C-(indol-3- yl)glycerol 3-phosphate to indole and glyceraldehyde 3-phosphate.The indole then migrates to the beta-subunit where, with serine in the presence of pyridoxal 5'-phosphate, it is converted to tryptophan.Also catalyzes the conversion of serine and indole into tryptophan and water, and of 1-C-(indol-3-yl)glycerol 3-phosphate into indole and glyceraldehyde phosphate (the latter reaction was listed formerly as EC 4.1.2.8).In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.1.48, EC 4.1.3.27 and EC 5.3.1.24). | IKU-IKReaction | 1-1-1
R0577 | R00036 | 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming) | 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming) | 2 5-Aminolevulinate <=> Porphobilinogen + 2 H2O | 2 C00430 <=> C00931 + 2 C00001 | irev | Forward | c | YALI0F20790g | 4.2.1.24 | hypothetical protein | Delta-aminolevulinic acid dehydratase | Porphyrin and chlorophyll metabolism | Zinc. |  | Unreviewed |  |  | IKU-IKUReaction | 1-1-1
R0578 | R00084 | porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing); porphobilinogen ammonia-lyase (polymerizing) | [NAME] (polymerizing) | [NAME] <=> Hydroxymethylbilane + 4 NH3 | 4 C00931 + C00001 <=> C01024 + 4 C00014 | irev | Forward | c | YALI0F26609g | 2.5.1.61 | hydroxymethylbilane synthase | Porphobilinogen deaminase | Porphyrin and chlorophyll metabolism | Dipyrromethane. | Porphyrin metabolism protoporphyrin-IX biosynthesis coproporphyrinogen-III from 5-aminolevulinate: step 2/4. | Reviewed |  | The enzyme works by stepwise addition of pyrrolylmethyl groups until a hexapyrrole is present at the active center.The terminal tetrapyrrole is then hydrolyzed to yield the product, leaving a cysteine-bound dipyrrole on which assembly continues.In the presence of a second enzyme, EC 4.2.1.75, which is often called cosynthase, the product is cyclized to form uroporphyrinogen III.If EC 4.2.1.75 is absent, the hydroxymethylbilane cyclizes spontaneously to form uroporphyrinogen I.Formerly EC 4.3.1.8. | IKU-IKUReaction | 1-1-1
R0579 | [NAME] | protoheme ferro-lyase (protoporphyrin-forming) | protoheme ferro-lyase (protoporphyrin-forming) | Protoporphyrin + Fe2+ <=> Heme + 2 H+ | C02191 + C14818 <=> C00032 + 2 C00080 | irev | Forward | m | YALI0F19470g | 4.99.1.1 | ferrochelatase | Ferrochelatase | Porphyrin and chlorophyll metabolism |  | Porphyrin metabolism protoheme biosynthesis protoheme from protoporphyrin-IX: step 1/1. | Unreviewed |  |  | IKU-IKUReaction | 1-1-1
R0581 | R02864 | S-Adenosyl-L-methionine:uroporphyrin-III C-methyltransferase | S-Adenosyl-L-methionine:uroporphyrin-III C-methyltransferase | Siroheme + 2 H+ <=> Fe2+ + Sirohydrochlorin | [NAME] <=> C14818 + C05778 | irev | Backward | c | [NAME] | 4.99.1.4 | hypothetical protein |  | Porphyrin and chlorophyll metabolism |  |  | Unreviewed |  | This enzyme catalyzes the third of three steps leading to the formation of siroheme from uroporphyrinogen III.The first step involves the donation of two S-adenosyl-L-methionine- derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107) and the second step involves an NAD(+)-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76).In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p.In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called [NAME], whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirB being responsible for the above reaction. | IKU-IKReaction | 1-n-n
R0582 | [NAME] | Hydroxymethylbilane hydro-lyase(cyclizing) | Hydroxymethylbilane hydro-lyase(cyclizing) | Hydroxymethylbilane <=> Uroporphyrinogen III + H2O | C01024 <=> C01051 + C00001 | irev | Forward | c | YALI0F09449g | 4.2.1.75 | hypothetical protein |  | Porphyrin and chlorophyll metabolism |  |  |  |  | In the presence of EC 2.5.1.61, forms uroporphyrinogen III from porphobilinogen. | IKU-IKReaction | 1-1-1
R0583 | R03194 | S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase | S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase | 2 S-Adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2 | 2 C00019 + C01051 <=> 2 C00021 + C02463 | irev | Forward | c | YALI0A01133g | 2.1.1.107 | hypothetical protein |  | Porphyrin and chlorophyll metabolism |  |  |  |  | This enzyme catalyzes two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2.It is the first of three steps leading to the formation of siroheme from uroporphyrinogen III.The second step involves an NAD(+)-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76) and the third step involves the chelation of [NAME]+) to sirohydrochlorin to form siroheme (EC 4.99.1.4).In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p.In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called [NAME], whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirA being responsible for the above reaction.Also involved in the biosynthesis of cobalamin. | IKU-IKReaction | 1-1-1
R0584 | [NAME] | Uroporphyrinogen-III carboxy-lyase | Uroporphyrinogen-III carboxy-lyase | Uroporphyrinogen III <=> Coproporphyrinogen III + 4 CO2 | C01051 <=> C03263 + 4 C00011 | irev | Forward | c | YALI0C01716g | 4.1.1.37 | uroporphyrinogen decarboxylase | Uroporphyrinogen decarboxylase | Porphyrin and chlorophyll metabolism |  | Porphyrin metabolism protoporphyrin-IX biosynthesis coproporphyrinogen III from 5-aminolevulinate: step 4/4. | Unreviewed |  | Acts on a number of porphyrinogens. | IKU-IKUReaction | 1-1-n
R0585 | R03220 | Coproporphyrinogen:oxygen oxidoreductase(decarboxylating) | Coproporphyrinogen:oxygen oxidoreductase(decarboxylating) | [NAME] H+ <=> Protoporphyrinogen IX + 2 CO2 + 2 H2O | C03263 + C00007 <=> C01079 + 2 C00011 + 2 C00001 | irev | Forward | c | YALI0E29975g | 1.3.3.3 | coproporphyrinogen oxidase |  | Porphyrin and chlorophyll metabolism | Iron. |  |  |  |  | IKU-IKReaction | 1-1-1
R0586 | R03222 | protoporphyrinogen-IX:oxygen oxidoreductase | protoporphyrinogen-IX:oxygen oxidoreductase | Protoporphyrinogen IX + 3 Oxygen <=> Protoporphyrin + 3 Hydrogen peroxide | C01079 + 3 C00007 <=> C02191 + 3 C00027 | irev | Forward | m | YALI0D23331g | 1.3.3.4 | protoporphyrinogen oxidase |  | Porphyrin and chlorophyll metabolism | FAD. |  |  |  | Also slowly oxidizes mesoporphyrinogen IX. | IKU-IKReaction | 1-1-1
R0588 | R03947 | S-Adenosyl-L-methionine:uroporphyrin-III C-methyltransferase | S-Adenosyl-L-methionine:uroporphyrin-III C-methyltransferase | Precorrin 2 + NAD+ <=> Sirohydrochlorin + NADH + H+ | C02463 + C00003 <=> C05778 + C00004 + C00080 | irev | Forward | c | [NAME] | 1.3.1.76 | hypothetical protein |  | Porphyrin and chlorophyll metabolism |  |  | Unreviewed |  | Catalyzes the second of three steps leading to the formation of siroheme from uroporphyrinogen III.The first step involves the donation of two S-adenosyl-L-methionine- derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107) and the third step involves the chelation of ferrous iron to sirohydrochlorin to form siroheme (EC 4.99.1.4).In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p.In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called [NAME], whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirC being responsible for the above reaction. | IKU-IKReaction | 1-n-n
R0592 | R00830 | succinyl-CoA:glycine C-succinyltransferase (decarboxylating) | succinyl-CoA:glycine C-succinyltransferase (decarboxylating) | Succinyl-CoA + Glycine <=> 5-Aminolevulinate + CoA + CO2 | C00091 + C00037 <=> C00430 + C00010 + C00011 | irev | Forward | m | [NAME] | 2.3.1.37 | 5-aminolevulinate synthase | 5-aminolevulinate synthase, mitochondrial | Porphyrin and chlorophyll metabolism | Pyridoxal 5'-phosphate. | Porphyrin metabolism protoporphyrin-IX biosynthesis 5- aminolevulinate from glycine: step 1/1. | Reviewed | Mitochondrion matrix (By similarity). |  | IKU-IKUReaction | 1-1-1
R0593 | R00908 | beta-alanine:2-oxoglutarate aminotransferase | beta-alanine:2-oxoglutarate aminotransferase | beta-Alanine + 2-Oxoglutarate <=> 3-Oxopropanoate + L-Glutamate | C00099 + C00026 <=> C00222 + C00025 | r |  | c | YALI0E18238g | 2.6.1.19 | 4-aminobutyrate aminotransferase apoenzyme |  | Propanoate metabolism |  |  | Unreviewed |  | Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate. | IKU-differenceReaction | 1-n-n
R0594 | R00926 | Propionyladenylate:CoA propionyltransferase | Propionyladenylate:CoA propionyltransferase | Propionyladenylate + CoA <=> AMP + Propanoyl-CoA | C05983 + C00010 <=> C00020 + C00100 | r |  | c | [NAME] | 6.2.1.1 | acetyl-coenzyme A synthetase |  | Propanoate metabolism |  |  |  |  | Also acts on propanoate and propenoate. | IKU-IKReaction | 1-1-n
[NAME] | R00935 | (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase (CoA-propanoylating) | (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase (CoA-propanoylating) | (S)-Methylmalonate semialdehyde + CoA + NAD+ <=> Propanoyl-CoA + CO2 + NADH + H+ | C06002 + C00010 + C00003 <=> C00100 + C00011 + C00004 + C00080 | r |  | c | YALI0C01859g | 1.2.1.27 | methylmalonate-semialdehyde dehydrogenase [acylating] |  | Propanoate metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0596 | R01354 | ATP:propanoate adenyltransferase | ATP:propanoate adenyltransferase | ATP + Propanoate <=> Diphosphate + Propionyladenylate | C00002 + C00163 <=> C00013 + C05983 | r |  | c | [NAME] | 6.2.1.1 | acetyl-coenzyme A synthetase |  | Propanoate metabolism |  |  |  |  | Also acts on propanoate and propenoate. | IKU-IKReaction | 1-1-n
R0597 | R00705 | 3-Oxopropanoate:NAD+ oxidoreductase (decarboxylating, CoA-acetylating) | 3-Oxopropanoate:NAD+ oxidoreductase (decarboxylating, CoA-acetylating) | 3-Oxopropanoate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+ | C00222 + C00010 + C00003 <=> C00024 + C00011 + C00004 + C00080 | irev | Forward | c | YALI0C01859g | 1.2.1.18 | methylmalonate-semialdehyde dehydrogenase [acylating] |  | Propanoate metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0598 | R00740 | 3-Oxopropanoate:NADP+ oxidoreductase (CoA-malonylating) | 3-Oxopropanoate:NADP+ oxidoreductase (CoA-malonylating) | 3-Oxopropanoate + CoA + NADP+ <=> Malonyl-CoA + NADPH + H+ | C00222 + C00010 + C00006 <=> C00083 + C00005 + C00080 | r |  | c | YALI0C01859g | 1.2.1.18 | methylmalonate-semialdehyde dehydrogenase [acylating] |  | Propanoate metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0606 | R02018 | 2'-Deoxyuridine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase | 2'-Deoxyuridine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase | dUDP + Thioredoxin disulfide + H2O <=> [NAME] | C01346 + C00343 + C00001 <=> C00342 + C00015 | irev | Backward | c | YALI0B03630g AND YALI0D03333g AND YALI0F31735g | 1.17.4.1 |  |  | Pyrimidine metabolism | Iron. |  |  |  | Responsible for the de novo conversion of ribonucleoside diphosphates into deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair.While the enzyme is activated by ATP, it is inhibited by dATP. | IKU-IKReaction | n-1-n
R0607 | R02024 | 2'-Deoxycytidine diphosphate:oxidized-thioredoxin 2'-oxidoreductase | 2'-Deoxycytidine diphosphate:oxidized-thioredoxin 2'-oxidoreductase | dCDP + Thioredoxin disulfide + H2O <=> Thioredoxin + CDP | C00705 + C00343 + C00001 <=> C00342 + C00112 | irev | Backward | c | YALI0B03630g AND YALI0D03333g AND YALI0F31735g | 1.17.4.1 |  |  | Pyrimidine metabolism | Iron. |  |  |  | Responsible for the de novo conversion of ribonucleoside diphosphates into deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair.While the enzyme is activated by ATP, it is inhibited by dATP. | IKU-IKReaction | n-1-n
R0608 | R01867 | dihydroorotate dehydrogenase (fumarate) | dihydroorotate dehydrogenase (fumarate) | (S)-Dihydroorotate + Fumarate <=> Orotate + Succinate | C00337 + C00122 <=> C00295 + C00042 | r |  | c | YALI0D18920g | 1.3.98.1 | dihydroorotate oxidase A |  | Pyrimidine metabolism | FAD; FMN. |  |  |  | Ferricyanide can act as acceptor. | IKU-IKReaction | 1-1-1
R0609 | R02016 | NADPH:oxidized-thioredoxin oxidoreductase | NADPH:oxidized-thioredoxin oxidoreductase | [NAME] <=> Thioredoxin disulfide + NADPH + H+ | C00342 + C00006 <=> C00343 + C00005 + C00080 | irev | Backward | c | YALI0D27126g | 1.8.1.9 | hypothetical protein | Thioredoxin reductase | Pyrimidine metabolism | Binds 1 FAD per subunit (By similarity). |  | Reviewed | Cytoplasm (By similarity). | May be identical to EC 1.8.1.10.Formerly EC 1.6.4.5. | IKU-IKUReaction | 1-1-n
R0610 | R02101 | 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase | 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase | dUMP + 5,10-Methylenetetrahydrofolate <=> Dihydrofolate + dTMP | C00365 + C00143 <=> C00415 + C00364 | irev | Forward | c | YALI0C10901g | 2.1.1.45 | thymidylate synthase | Thymidylate synthase | Pyrimidine metabolism |  | Pyrimidine metabolism dTTP biosynthesis. | Unreviewed |  |  | IKU-IKUReaction | 1-1-1
R0611 | R01397 | carbamoyl-phosphate:L-aspartate carbamoyltransferase | carbamoyl-phosphate:L-aspartate carbamoyltransferase | Carbamoyl phosphate + L-Aspartate <=> Orthophosphate + N-Carbamoyl-L-aspartate | C00169 + C00049 <=> C00009 + C00438 | irev | Forward | n | YALI0E09493g | 2.1.3.2 | carbamoyl-phosphate synthase large subunit / carbamoyl-phosphate synthase small subunit |  | Pyrimidine metabolism |  |  | Unreviewed |  |  | IKU-IU-noECnoReaction | 1-1-1
R0612 | R02484 | deoxyuridine:orthophosphate 2-deoxy-D-ribosyltransferase; deoxyuridine:orthophosphate ribosyltransferase | deoxyuridine:orthophosphate 2-deoxy-D-ribosyltransferase | Deoxyuridine + Orthophosphate <=> Uracil + 2-Deoxy-D-ribose 1-phosphate | C00526 + C00009 <=> C00106 + C00672 | irev | Forward | c | YALI0F30129g | 2.4.2.1 | hypothetical protein |  | Pyrimidine metabolism |  |  |  |  | Specificity not completely determined.Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5. | IKU-IKReaction | 1-1-n
R0613 | R01870 | Orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase | Orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase | Orotidine 5'-phosphate + Diphosphate <=> Orotate + 5-Phospho-alpha-D-ribose 1-diphosphate | C01103 + C00013 <=> C00295 + C00119 | r |  | c | YALI0F21527g | 2.4.2.10 | orotate phosphoribosyltransferase | Orotate phosphoribosyltransferase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via de novo pathway UMP from orotate: step 1/2. | Reviewed |  | The enzyme from higher eukaryotes also catalyzes the reaction listed as EC 4.1.1.23. | IKU-IKUReaction | 1-1-1
R0614 | R00966 | UMP:diphosphate phospho-alpha-D-ribosyltransferase | UMP:diphosphate phospho-alpha-D-ribosyltransferase | UMP + Diphosphate <=> Uracil + 5-Phospho-alpha-D-ribose 1-diphosphate | C00105 + C00013 <=> C00106 + C00119 | irev | Backward | c | YALI0E20625g OR YALI0F31273g | 2.4.2.9 |  |  | Pyrimidine metabolism |  |  |  |  |  | IKU-IKReaction | n-1-1
R0615 | R00513 | ATP:cytidine 5'-phosphotransferase | ATP:cytidine 5'-phosphotransferase | ATP + Cytidine <=> ADP + CMP | C00002 + C00475 <=> C00008 + C00055 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0616 | R00516 | UTP:cytidine 5'-phosphotransferase | UTP:cytidine 5'-phosphotransferase | UTP + Cytidine <=> UDP + CMP | C00075 + C00475 <=> C00015 + C00055 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
[NAME] | R00517 | GTP:cytidine 5'-phosphotransferase | GTP:cytidine 5'-phosphotransferase | GTP + Cytidine <=> GDP + CMP | C00044 + C00475 <=> C00035 + C00055 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
[NAME] | R00962 | ITP:cytidine 5'-phosphotransferase | ITP:cytidine 5'-phosphotransferase | ITP + Cytidine <=> IDP + CMP | C00081 + C00475 <=> C00104 + C00055 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0619 | R00964 | ATP:uridine 5'-phosphotransferase | ATP:uridine 5'-phosphotransferase | ATP + Uridine <=> ADP + UMP | C00002 + C00299 <=> C00008 + C00105 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0620 | R00967 | UTP:uridine 5'-phosphotransferase | UTP:uridine 5'-phosphotransferase | UTP + Uridine <=> UDP + UMP | C00075 + C00299 <=> C00015 + C00105 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0621 | R00968 | GTP:uridine 5'-phosphotransferase | GTP:uridine 5'-phosphotransferase | GTP + Uridine <=> GDP + UMP | C00044 + C00299 <=> C00035 + C00105 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0622 | R00970 | ITP:uridine 5'-phosphotransferase | ITP:uridine 5'-phosphotransferase | ITP + Uridine <=> IDP + UMP | C00081 + C00299 <=> C00104 + C00105 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0623 | R01548 | dATP:cytidine 5'-phosphotransferase | dATP:cytidine 5'-phosphotransferase | dATP + Cytidine <=> dADP + CMP | C00131 + C00475 <=> C00206 + C00055 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0624 | R01549 | dATP:uridine 5'-phosphotransferase | dATP:uridine 5'-phosphotransferase | dATP + Uridine <=> dADP + UMP | C00131 + C00299 <=> C00206 + C00105 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0625 | R01880 | dGTP:uridine 5'-phosphotransferase | dGTP:uridine 5'-phosphotransferase | dGTP + Uridine <=> dGDP + UMP | C00286 + C00299 <=> C00361 + C00105 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0626 | R02091 | dGTP:cytidine 5'-phosphotransferase | dGTP:cytidine 5'-phosphotransferase | dGTP + Cytidine <=> dGDP + CMP | C00286 + C00475 <=> C00361 + C00055 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0627 | R02096 | dTTP:cytidine 5'-phosphotransferase | dTTP:cytidine 5'-phosphotransferase | dTTP + Cytidine <=> dTDP + CMP | C00459 + C00475 <=> C00363 + C00055 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0628 | R02097 | dTTP:uridine 5'-phosphotransferase | dTTP:uridine 5'-phosphotransferase | dTTP + Uridine <=> dTDP + UMP | C00459 + C00299 <=> C00363 + C00105 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0629 | R02327 | dCTP:uridine 5'-phosphotransferase | dCTP:uridine 5'-phosphotransferase | dCTP + Uridine <=> dCDP + UMP | C00458 + C00299 <=> C00705 + C00105 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0630 | [NAME] | dUTP:uridine 5'-phosphotransferase | dUTP:uridine 5'-phosphotransferase | dUTP + Uridine <=> dUDP + UMP | C00460 + C00299 <=> C01346 + C00105 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0631 | R02371 | dCTP:cytidine 5'-phosphotransferase | dCTP:cytidine 5'-phosphotransferase | dCTP + Cytidine <=> dCDP + CMP | C00458 + C00475 <=> C00705 + C00055 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0632 | R02372 | dUTP:cytidine 5'-phosphotransferase | dUTP:cytidine 5'-phosphotransferase | dUTP + Cytidine <=> dUDP + CMP | C00460 + C00475 <=> C01346 + C00055 | irev | Forward | c | YALI0E31009g | 2.7.1.48 | uridine kinase | Uridine kinase | Pyrimidine metabolism |  | Pyrimidine metabolism UMP biosynthesis via salvage pathway UMP from uridine: step 1/1. | Unreviewed |  | Cytidine can act as acceptor.GTP and ITP can act as donors. | IKU-KUReaction | 1-1-n
R0633 | R00158 | ATP:UMP phosphotransferase | ATP:UMP phosphotransferase | ATP + UMP <=> ADP + UDP | C00002 + C00105 <=> C00008 + C00015 | r |  | c | YALI0F09339g | 2.7.4.14 | Adenylate kinase |  | Pyrimidine metabolism |  |  | Unreviewed |  | This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.dCMP can also act as acceptor.Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase.This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.dCMP can also act as acceptor.Different from the monofunctional prokaryotic enzymes EC 2.7.4.25 and EC 2.7.4.22.Formerly EC 2.7.4.5. | IKU-differenceReaction | 1-1-n
R0634 | R00512 | ATP:CMP phosphotransferase | ATP:CMP phosphotransferase | ATP + CMP <=> ADP + CDP | C00002 + C00055 <=> C00008 + C00112 | r |  | c | YALI0F09339g | 2.7.4.14 | Adenylate kinase |  | Pyrimidine metabolism |  |  | Unreviewed |  | This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.dCMP can also act as acceptor.Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase.This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.dCMP can also act as acceptor.Different from the monofunctional prokaryotic enzymes EC 2.7.4.25 and EC 2.7.4.22.Formerly EC 2.7.4.5. | IKU-differenceReaction | 1-1-n
[NAME] | R01665 | ATP:dCMP phosphotransferase | ATP:dCMP phosphotransferase | ATP + dCMP <=> ADP + dCDP | C00002 + C00239 <=> C00008 + C00705 | r |  | c | YALI0F09339g | 2.7.4.14 | Adenylate kinase |  | Pyrimidine metabolism |  |  | Unreviewed |  | This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.dCMP can also act as acceptor.Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase.This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency.dCMP can also act as acceptor.Different from the monofunctional prokaryotic enzymes EC 2.7.4.25 and EC 2.7.4.22.Formerly EC 2.7.4.5. | IKU-differenceReaction | 1-1-n
R0636 | R00156 | ATP:UDP phosphotransferase | ATP:UDP phosphotransferase | ATP + UDP <=> ADP + UTP | C00002 + C00015 <=> C00008 + C00075 | r |  | c | YALI0F09229g | 2.7.4.6 | nucleoside diphosphate kinase | Nucleoside diphosphate kinase | Pyrimidine metabolism |  |  | Unreviewed |  | Many nucleoside diphosphates can act as acceptors.Many ribo- and deoxyribonucleoside triphosphates can act as donors. | IKU-IKUReaction | 1-1-n
R0637 | R00570 | ATP:CDP phosphotransferase | ATP:CDP phosphotransferase | ATP + CDP <=> ADP + CTP | C00002 + C00112 <=> C00008 + C00063 | r |  | c | YALI0F09229g | 2.7.4.6 | nucleoside diphosphate kinase | Nucleoside diphosphate kinase | Pyrimidine metabolism |  |  | Unreviewed |  | Many nucleoside diphosphates can act as acceptors.Many ribo- and deoxyribonucleoside triphosphates can act as donors. | IKU-IKUReaction | 1-1-n
R0638 | R02093 | ATP:dTDP phosphotransferase | ATP:dTDP phosphotransferase | ATP + dTDP <=> ADP + dTTP | C00002 + C00363 <=> C00008 + C00459 | r |  | c | YALI0F09229g | 2.7.4.6 | nucleoside diphosphate kinase | Nucleoside diphosphate kinase | Pyrimidine metabolism |  |  | Unreviewed |  | Many nucleoside diphosphates can act as acceptors.Many ribo- and deoxyribonucleoside triphosphates can act as donors. | IKU-IKUReaction | 1-1-n
R0639 | R02326 | ATP:dCDP phosphotransferase | ATP:dCDP phosphotransferase | ATP + dCDP <=> ADP + dCTP | C00002 + C00705 <=> C00008 + C00458 | r |  | c | YALI0F09229g | 2.7.4.6 | nucleoside diphosphate kinase | Nucleoside diphosphate kinase | Pyrimidine metabolism |  |  | Unreviewed |  | Many nucleoside diphosphates can act as acceptors.Many ribo- and deoxyribonucleoside triphosphates can act as donors. | IKU-IKUReaction | 1-1-n
R0640 | R02331 | ATP:dUDP phosphotransferase | ATP:dUDP phosphotransferase | ATP + dUDP <=> ADP + dUTP | C00002 + C01346 <=> C00008 + C00460 | r |  | c | YALI0F09229g | 2.7.4.6 | nucleoside diphosphate kinase | Nucleoside diphosphate kinase | Pyrimidine metabolism |  |  | Unreviewed |  | Many nucleoside diphosphates can act as acceptors.Many ribo- and deoxyribonucleoside triphosphates can act as donors. | IKU-IKUReaction | 1-1-n
R0641 | R02094 | ATP:dTMP phosphotransferase | ATP:dTMP phosphotransferase | ATP + dTMP <=> ADP + dTDP | C00002 + C00364 <=> C00008 + C00363 | r |  | c | YALI0C13354g | 2.7.4.9 | thymidylate kinase |  | Pyrimidine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0642 | R02098 | ATP:dUMP phosphotransferase | ATP:dUMP phosphotransferase | ATP + dUMP <=> ADP + dUDP | C00002 + C00365 <=> C00008 + C01346 | r |  | c | YALI0C13354g | 2.7.4.9 | thymidylate kinase |  | Pyrimidine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0647 | R00511 | Cytidine-5'-monophosphate phosphohydrolase | Cytidine-5'-monophosphate phosphohydrolase | CMP + H2O <=> Cytidine + Orthophosphate | C00055 + C00001 <=> C00475 + C00009 | irev | Forward | c | YALI0A08217g OR YALI0C19866g | 3.1.3.5 |  |  | Pyrimidine metabolism |  |  |  |  | Wide specificity for 5'-nucleotides. | IKU-IKReaction | n-1-n
R0648 | R00963 | Uridine 5'-monophosphate phosphohydrolase | Uridine 5'-monophosphate phosphohydrolase | UMP + H2O <=> Uridine + Orthophosphate | C00105 + C00001 <=> C00299 + C00009 | irev | Forward | c | YALI0A08217g OR YALI0C19866g | 3.1.3.5 |  |  | Pyrimidine metabolism |  |  |  |  | Wide specificity for 5'-nucleotides. | IKU-IKReaction | n-1-n
R0649 | R01569 | Thymidylate 5'-phosphohydrolase | Thymidylate 5'-phosphohydrolase | dTMP + H2O <=> Thymidine + Orthophosphate | C00364 + C00001 <=> C00214 + C00009 | irev | Forward | c | YALI0A08217g OR YALI0C19866g | 3.1.3.5 |  |  | Pyrimidine metabolism |  |  |  |  | Wide specificity for 5'-nucleotides. | IKU-IKReaction | n-1-n
R0650 | [NAME] | 2'-Deoxycytidine 5'-monophosphate phosphohydrolase | 2'-Deoxycytidine 5'-monophosphate phosphohydrolase | dCMP + H2O <=> Deoxycytidine + Orthophosphate | C00239 + C00001 <=> C00881 + C00009 | irev | Forward | c | YALI0A08217g OR YALI0C19866g | 3.1.3.5 |  |  | Pyrimidine metabolism |  |  |  |  | Wide specificity for 5'-nucleotides. | IKU-IKReaction | n-1-n
R0651 | R01993 | (S)-dihydroorotate amidohydrolase | (S)-dihydroorotate amidohydrolase | (S)-Dihydroorotate + H2O <=> N-Carbamoyl-L-aspartate | C00337 + C00001 <=> C00438 | r |  | n | YALI0F22781g | 3.5.2.3 | dihydroorotase |  | Pyrimidine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
[NAME] | R00974 | Cytosine aminohydrolase | Cytosine aminohydrolase | Cytosine + H2O <=> Uracil + NH3 | C00380 + C00001 <=> C00106 + C00014 | irev | Forward | c | YALI0F22517g | 3.5.4.1 | hypothetical protein |  | Pyrimidine metabolism |  |  |  |  | Also acts on 5-methylcytosine. | IKU-IKReaction | 1-1-n
R0654 | R01663 | dCMP aminohydrolase | dCMP aminohydrolase | dCMP + H2O <=> dUMP + NH3 | C00239 + C00001 <=> C00365 + C00014 | r | Forward | c | YALI0C23210g | 3.5.4.12 | hypothetical protein |  | Pyrimidine metabolism |  |  |  |  | Also acts on some 5-substituted dCMPs. | IKU-IKReaction | 1-1-1
R0655 | R01878 | Cytidine aminohydrolase | Cytidine aminohydrolase | Cytidine + H2O <=> Uridine + NH3 | C00475 + C00001 <=> C00299 + C00014 | irev | Forward | c | YALI0D17072g | 3.5.4.5 | cytidine deaminase |  | Pyrimidine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0656 | R02485 | Deoxycytidine aminohydrolase | Deoxycytidine aminohydrolase | Deoxycytidine + H2O <=> Deoxyuridine + NH3 | C00881 + C00001 <=> C00526 + C00014 | irev | Forward | c | YALI0D17072g | 3.5.4.5 | cytidine deaminase |  | Pyrimidine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0657 | R02100 | dUTP nucleotidohydrolase | dUTP nucleotidohydrolase | dUTP + H2O <=> dUMP + Diphosphate | C00460 + C00001 <=> C00365 + C00013 | irev | Forward | c | [NAME] | 3.6.1.23 | deoxyuridine 5'-triphosphate nucleotidohydrolase | Deoxyuridine 5'-triphosphate nucleotidohydrolase | Pyrimidine metabolism | [NAME] (By similarity). | Pyrimidine metabolism dUMP biosynthesis dUMP from dCTP (dUTP route): step 2/2. | Reviewed |  |  | IKU-IKUReaction | 1-1-1
R0658 | R00155 | UDP phosphohydrolase | UDP phosphohydrolase | UDP + H2O <=> UMP + Orthophosphate | C00015 + C00001 <=> C00105 + C00009 | irev | Forward | c | YALI0C19712g | 3.6.1.5 | hypothetical protein |  | Pyrimidine metabolism | Calcium. |  |  |  | Also acts on ADP, and on other nucleoside triphosphates and diphosphates.Most of the ecto-ATPases occurring on the cell surface and hydrolyzing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. | IKU-IKReaction | 1-1-n
R0659 | R00159 | UTP phosphohydrolase | UTP phosphohydrolase | UTP + H2O <=> UDP + Orthophosphate | C00075 + C00001 <=> C00015 + C00009 | irev | Forward | c | YALI0C19712g | 3.6.1.5 | hypothetical protein |  | Pyrimidine metabolism | Calcium. |  |  |  | Also acts on ADP, and on other nucleoside triphosphates and diphosphates.Most of the ecto-ATPases occurring on the cell surface and hydrolyzing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. | IKU-IKReaction | 1-1-n
R0660 | R00514 | CDP phosphohydrolase | CDP phosphohydrolase | CDP + H2O <=> CMP + Orthophosphate | C00112 + C00001 <=> C00055 + C00009 | irev | Forward | c | YALI0C19712g | 3.6.1.5 | hypothetical protein |  | Pyrimidine metabolism | Calcium. |  |  |  | Also acts on ADP, and on other nucleoside triphosphates and diphosphates.Most of the ecto-ATPases occurring on the cell surface and hydrolyzing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. | IKU-IKReaction | 1-1-n
R0661 | R00569 | CTP phosphohydrolase | CTP phosphohydrolase | CTP + H2O <=> CDP + Orthophosphate | C00063 + C00001 <=> C00112 + C00009 | irev | Forward | c | YALI0C19712g | 3.6.1.5 | hypothetical protein |  | Pyrimidine metabolism | Calcium. |  |  |  | Also acts on ADP, and on other nucleoside triphosphates and diphosphates.Most of the ecto-ATPases occurring on the cell surface and hydrolyzing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. | IKU-IKReaction | 1-1-n
R0662 | R02092 | dTDP phosphohydrolase | dTDP phosphohydrolase | dTDP + H2O <=> dTMP + Orthophosphate | C00363 + C00001 <=> C00364 + C00009 | irev | Forward | c | YALI0C19712g | 3.6.1.5 | hypothetical protein |  | Pyrimidine metabolism | Calcium. |  |  |  | Also acts on ADP, and on other nucleoside triphosphates and diphosphates.Most of the ecto-ATPases occurring on the cell surface and hydrolyzing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. | IKU-IKReaction | 1-1-n
R0663 | [NAME] | dTTP nucleotidohydrolase | dTTP nucleotidohydrolase | dTTP + H2O <=> dTDP + Orthophosphate | C00459 + C00001 <=> C00363 + C00009 | irev | Forward | c | YALI0C19712g | 3.6.1.5 | hypothetical protein |  | Pyrimidine metabolism | Calcium. |  |  |  | Also acts on ADP, and on other nucleoside triphosphates and diphosphates.Most of the ecto-ATPases occurring on the cell surface and hydrolyzing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. | IKU-IKReaction | 1-1-n
R0664 | [NAME] | UTP:ammonia ligase (ADP-forming) | UTP:ammonia ligase (ADP-forming) | ATP + UTP + NH3 <=> ADP + Orthophosphate + CTP | C00002 + C00075 + C00014 <=> C00008 + C00009 + C00063 | irev | Forward | c | YALI0B05368g | 6.3.4.2 | CTP synthase |  | Pyrimidine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0665 | R00573 | UTP:L-glutamine amido-ligase (ADP-forming) | UTP:L-glutamine amido-ligase (ADP-forming) | ATP + UTP + L-Glutamine + H2O <=> ADP + Orthophosphate + CTP + L-Glutamate | C00002 + C00075 + C00064 + C00001 <=> C00008 + C00009 + C00063 + C00025 | irev | Forward | c | YALI0B05368g | 6.3.4.2 | CTP synthase |  | Pyrimidine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0666 | R00575 | hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) | hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) | 2 ATP + L-Glutamine + HCO3- + H2O <=> 2 ADP + Orthophosphate + L-Glutamate + Carbamoyl phosphate | 2 C00002 + C00064 + C00288 + C00001 <=> 2 C00008 + C00009 + C00025 + C00169 | irev | Forward | c | YALI0C23969g AND YALI0D07370g OR YALI0E09493g | 6.3.5.5 |  |  | Pyrimidine metabolism |  |  |  |  | The product carbamoyl phosphate is an intermediate in the biosynthesis of arginine and the pyrimidine nucleotides.The enzyme from Escherichia coli has three separate active sites, which are connected by a molecular tunnel that is almost 100 A in length.The amidotransferase domain within the small subunit of the enzyme hydrolyzes glutamine to ammonia via a thioester intermediate.The ammonia migrates through the interior of the protein, where it reacts with carboxy phosphate to produce the carbamate intermediate.The carboxy-phosphate intermediate is formed by the phosphorylation of bicarbonate by ATP at a site contained within the N-terminal half of the large subunit.The carbamate intermediate is transported through the interior of the protein to a second site within the C-terminal half of the large subunit, where it is phosphorylated by another ATP to yield the final product, carbamoyl phosphate.Formerly EC 2.7.2.9. | IKU-IU-noECnoReaction | n-1-1
R0667 | [NAME] | (S)-Lactate:ferricytochrome-c 2-oxidoreductase | (S)-Lactate:ferricytochrome-c 2-oxidoreductase | (S)-Lactate + 2 Ferricytochrome c <=> Pyruvate + 2 Ferrocytochrome c + 2 H+ | C00186 + 2 C00125 <=> C00022 + 2 C00126 + 2 C00080 | irev | Forward | m | YALI0E21307g | 1.1.2.3 | hypothetical protein |  | Pyruvate metabolism | FMN; Protoheme IX. |  |  |  |  | IKU-IKReaction | 1-1-1
R0668 | R00197 | (R)-Lactate:ferricytochrome-c 2-oxidoreductase | (R)-Lactate:ferricytochrome-c 2-oxidoreductase | (R)-Lactate + 2 Ferricytochrome c <=> Pyruvate + 2 Ferrocytochrome c + 2 H+ | C00256 + 2 C00125 <=> C00022 + 2 C00126 + 2 C00080 | irev | Forward | m | YALI0E03212g | 1.1.2.4 | hypothetical protein |  | Pyruvate metabolism | FAD |  |  |  |  | IKU-IKReaction | 1-1-1
R0669 | R00214 | (S)-malate:NAD+ oxidoreductase (decarboxylating) | (S)-malate:NAD+ oxidoreductase (decarboxylating) | (S)-Malate + NAD+ <=> Pyruvate + CO2 + NADH + H+ | C00149 + C00003 <=> C00022 + C00011 + C00004 + C00080 | irev | Forward | m | [NAME] | 1.1.1.38 | hypothetical protein |  | Pyruvate metabolism |  |  |  |  | Also decarboxylates added oxaloacetate. | IKU-IKReaction | 1-1-1
R0670 | R00227 | Acetyl-CoA hydrolase | Acetyl-CoA hydrolase | Acetyl-CoA + H2O <=> CoA + Acetate | C00024 + C00001 <=> C00010 + C00033 | irev | Backward | c | YALI0E30965g | 3.1.2.1 | hypothetical protein | Acetyl-CoA hydrolase | Pyruvate metabolism |  |  | Reviewed | Cytoplasm (By similarity). |  | IKU-IKUReaction | 1-1-1
R0671 | R00342 | (S)-malate:NAD+ oxidoreductase | (S)-malate:NAD+ oxidoreductase | (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ | C00149 + C00003 <=> C00036 + C00004 + C00080 | r |  | m | YALI0D16753g OR YALI0E14190g | 1.1.1.37 | malate dehydrogenase (NAD) | Malate dehydrogenase | Pyruvate metabolism |  |  | Unreviewed |  | Also oxidizes some other 2-hydroxydicarboxylic acids. | IKU-IKUReaction | n-1-1
R0672 | R00472 | acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); L-Malate glyoxylate-lyase (CoA-acetylating) | L-Malate glyoxylate-lyase (CoA-acetylating) | (S)-Malate + CoA <=> Acetyl-CoA + H2O + Glyoxylate | C00149 + C00010 <=> C00024 + C00001 + C00048 | irev | Backward | m | YALI0D19140g OR YALI0E15708g | 2.3.3.9 | hypothetical protein | Malate synthase | Pyruvate metabolism |  | Carbohydrate metabolism glyoxylate cycle (S)-malate from isocitrate: step 2/2. | Unreviewed |  | Formerly EC 4.1.3.2. | IKU-IKUReaction | n-1-1
R0673 | [NAME] | (R)-S-Lactoylglutathione hydrolase | (R)-S-Lactoylglutathione hydrolase | (R)-S-Lactoylglutathione + H2O <=> Glutathione + (R)-Lactate | C03451 + C00001 <=> C00051 + C00256 | irev | Forward | c | YALI0D06974g | 3.1.2.6 | hypothetical protein |  | Pyruvate metabolism |  |  |  |  | Also hydrolyzes S-acetoacetylglutathione, more slowly.Formerly EC 3.1.2.8. | IKU-IKReaction | 1-1-1
R0674 | R02530 | (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing) | (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing) | (R)-S-Lactoylglutathione <=> Glutathione + Methylglyoxal | C03451 <=> C00051 + C00546 | r |  | c | YALI0E24057g | 4.4.1.5 | hypothetical protein |  | Pyruvate metabolism |  |  |  |  | Also acts on 3-phosphoglycerol-glutathione. | IKU-IKReaction | 1-1-1
R0675 | R00238 | Acetyl-CoA:acetyl-CoA C-acetyltransferase | Acetyl-CoA:acetyl-CoA C-acetyltransferase | 2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA | 2 C00024 <=> C00010 + C00332 | irev | Forward | c | YALI0B08536g OR YALI0E11099g | 2.3.1.9 | acetyl-CoA acetyltransferase | Acetyl-CoA acetyltransferase | Pyruvate metabolism |  |  | Reviewed OR Unreviewed | Peroxisome. |  | IKU-IKReaction | n-1-n
R0676 | R00066 | 6,7-Dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase | 6,7-Dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase | 2 6,7-Dimethyl-8-(D-ribityl)lumazine <=> Riboflavin + 5-Amino-6-(1-D-ribitylamino)uracil | 2 C04332 <=> C00255 + C04732 | irev | Forward | c | YALI0C01111g | 2.5.1.9 | hypothetical protein |  | [NAME] metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0677 | R00161 | ATP:FMN adenylyltransferase | ATP:FMN adenylyltransferase | ATP + FMN <=> Diphosphate + FAD | C00002 + C00061 <=> C00013 + C00016 | irev | Forward | c | YALI0D25564g | 2.7.7.2 | hypothetical protein |  | [NAME] metabolism | Magnesium. |  |  |  | Highly specific for ATP as phosphate donor.The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin [NAME], vitamin B12 and folates.While monofunctional FAD synthetase is found in eukaryotes and in some prokaryotes, most prokaryotes have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.1.26. | IKU-IKReaction | 1-1-1
R0678 | [NAME] | GTP 7,8-8,9-dihydrolase (diphosphate-forming) | GTP 7,8-8,9-dihydrolase (diphosphate-forming) | GTP + 3 H2O <=> Formate + 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + Diphosphate | C00044 + 3 C00001 <=> C00058 + C01304 + C00013 | irev | Forward | c | YALI0E02288g | 3.5.4.25 | GTP cyclohydrolase II | GTP cyclohydrolase-2 | [NAME] metabolism |  | Cofactor biosynthesis riboflavin biosynthesis 5-amino- 6-(D-ribitylamino)uracil from GTP: step 1/4. | Unreviewed |  | Two C-N bonds are hydrolyzed, releasing formate, with simultaneous removal of the terminal diphosphate. | IKU-IKUReaction | 1-1-1
R0679 | [NAME] | riboflavin-5-phosphate phosphohydrolase (acid optimum) | riboflavin-5-phosphate phosphohydrolase (acid optimum) | FMN + H2O <=> [NAME] | C00061 + C00001 <=> C00255 + C00009 | irev | Forward | e | YALI0A12573g OR YALI0E32681g OR YALI0E35222g OR YALI0F23067g OR [NAME]g | 3.1.3.2 |  |  | [NAME] metabolism |  |  |  |  | Wide specificity.Also catalyzes transphosphorylations. | IKU-IKReaction | n-1-1
R0680 | R00549 | ATP:riboflavin 5'-phosphotransferase | ATP:riboflavin 5'-phosphotransferase | ATP + Riboflavin <=> ADP + FMN | C00002 + C00255 <=> C00008 + C00061 | irev | Forward | c | YALI0B01826g | 2.7.1.26 | hypothetical protein | [NAME] kinase | [NAME] metabolism | Magnesium or zinc | Cofactor biosynthesis FMN biosynthesis FMN from riboflavin (ATP route): step 1/1. | Reviewed |  | The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B(6), vitamin B12 and folates.While monofunctional riboflavin kinase is found in eukaryotes, some bacteria have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.7.2.In Bacillus subtilis, ATP can be replaced by other phosphate donors but with decreasing enzyme activity in the order ATP > dATP > CTP > UTP. | IKU-IKUReaction | 1-1-1
R0681 | R04457 | 5-amino-6-(D-ribitylamino)uracil butanedionetransferase | 5-amino-6-(D-ribitylamino)uracil butanedionetransferase | 5-Amino-6-(1-D-ribitylamino)uracil + L-3,4-Dihydroxybutan-2-one 4-phosphate <=> 6,7-Dimethyl-8-(D-ribityl)lumazine + 2 H2O + Orthophosphate | C04732 + C15556 <=> C04332 + 2 C00001 + C00009 | irev | Forward | c | YALI0A12045g | 2.5.1.78 | 6,7-dimethyl-8-ribityllumazine synthase | 6,7-dimethyl-8-ribityllumazine synthase | [NAME] metabolism |  | Cofactor biosynthesis riboflavin biosynthesis riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D- ribitylamino)uracil: step 2/2. | Unreviewed |  | Involved in riboflavin biosynthesis. | IKU-IUReaction | 1-1-1
R0682 | R07281 | D-ribulose 5-phosphate formate-lyase (L-3,4-dihydroxybutan-2-one 4-phosphate-forming) | D-ribulose 5-phosphate formate-lyase (L-3,4-dihydroxybutan-2-one 4-phosphate-forming) | D-Ribulose 5-phosphate <=> L-3,4-Dihydroxybutan-2-one 4-phosphate + Formate | C00199 <=> C15556 + C00058 | irev | Forward | c | YALI0B08965g | 4.1.99.12 | 3,4-dihydroxy-2-butanone 4-phosphate synthase | 3,4-dihydroxy-2-butanone 4-phosphate synthase | [NAME] metabolism | Magnesium. | Cofactor biosynthesis riboflavin biosynthesis 2- hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1. | Unreviewed |  | The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect [NAME] and [NAME] to [NAME] being broken, [NAME] being removed as formate and reconnection of C-3 and C-5.The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin. | IKU-differenceReaction | 1-1-1
R0683 | R09375 | 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one:NAD+ 1'-oxidoreductase | 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one:NAD+ 1'-oxidoreductase | 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NADH + H+ <=> 2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD+ | C01304 + C00004 + C00080 <=> C18910 + C00003 | irev | Forward | c | YALI0D06501g | 1.1.1.302 | hypothetical protein |  | [NAME] metabolism |  |  | Unreviewed |  | The reaction proceeds in the opposite direction.A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant.Differs from EC 1.1.1.193 since it does not catalyze the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate. | IKU-differenceReaction | 1-1-n
[NAME] | [NAME] | 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one:NADP+ 1'-oxidoreductase | 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one:NADP+ 1'-oxidoreductase | 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NADPH + H+ <=> 2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NADP+ | C01304 + C00005 + C00080 <=> C18910 + C00006 | irev | Forward | c | YALI0D06501g | 1.1.1.302 | hypothetical protein |  | [NAME] metabolism |  |  | Unreviewed |  | The reaction proceeds in the opposite direction.A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant.Differs from EC 1.1.1.193 since it does not catalyze the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate. | IKU-differenceReaction | 1-1-n
R0685 | R09377 | 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one 2-aminohydrolase | 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one 2-aminohydrolase | 2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O <=> 5-Amino-6-(5'-phospho-D-ribitylamino)uracil + NH3 | C18910 + C00001 <=> [NAME] | irev | Forward | c | [NAME] |  |  |  | [NAME] metabolism
R0686 | R00508 | 3'-Phospho-5'-adenylyl sulfate 3'-phosphohydrolase | 3'-Phospho-5'-adenylyl sulfate 3'-phosphohydrolase | 3'-Phosphoadenylyl sulfate + H2O <=> Adenylyl sulfate + Orthophosphate | C00053 + C00001 <=> C00224 + C00009 | irev | Forward | c | YALI0F27665g | 3.1.3.7 | hypothetical protein |  | Sulfur metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0687 | R00509 | ATP:adenylylsulfate 3'-phosphotransferase | ATP:adenylylsulfate 3'-phosphotransferase | ATP + Adenylyl sulfate <=> ADP + 3'-Phosphoadenylyl sulfate | C00002 + C00224 <=> C00008 + C00053 | irev | Forward | c | YALI0E00418g | 2.7.1.25 | adenylylsulfate kinase | Adenylyl-sulfate kinase | Sulfur metabolism |  | Sulfur metabolism hydrogen sulfide biosynthesis sulfite from sulfate: step 2/3. | Unreviewed |  | The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme bound APS and ATP.This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of PAPS is carried out by two individual polypeptides, EC 2.7.7.4 and EC 2.7.1.25. | IKU-IKUReaction | 1-1-1
R0688 | R00529 | ATP:sulfate adenylyltransferase | ATP:sulfate adenylyltransferase | ATP + Sulfate <=> Diphosphate + Adenylyl sulfate | C00002 + C00059 <=> C00013 + C00224 | irev | Forward | c | YALI0B08184g | 2.7.7.4 | sulfate adenylyltransferase | Sulfate adenylyltransferase | Sulfur metabolism |  | Sulfur metabolism hydrogen sulfide biosynthesis sulfite from sulfate: step 1/3. | Reviewed | Cytoplasm (By similarity). | The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme bound APS and ATP.This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of PAPS is carried out by two individual polypeptides, EC 2.7.7.4 and EC 2.7.1.25. | IKU-KUReaction | 1-1-n
R0689 | R00858 | hydrogen-sulfide:NADP+ oxidoreductase | hydrogen-sulfide:NADP+ oxidoreductase | Hydrogen sulfide + 3 NADP+ + 3 H2O <=> Sulfite + 3 NADPH + 3 H+ | C00283 + 3 C00006 + 3 C00001 <=> C00094 + 3 C00005 + 3 C00080 | irev | Backward | c | [NAME] YALI0E16368g | 1.8.1.2 |  |  | Sulfur metabolism | FAD; FMN; Heme. |  |  |  |  | IKU-IKReaction | n-1-1
R0690 | R02021 | adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate -forming) | adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate -forming) | [NAME] sulfate <=> Thioredoxin disulfide [NAME] 3',5'-bisphosphate | C00342 + C00053 <=> C00343 + C00094 + C00054 | irev | Forward | c | YALI0B08140g | 1.8.4.8 | phosphoadenylylsulfate reductase (thioredoxin) |  | Sulfur metabolism |  |  |  |  | Specific for PAPS.The enzyme from Escherichia coli will use thioredoxins from other species.Formerly EC 1.8.99.4. | IKU-IKReaction | 1-1-1
R0691 | R01281 | Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) | Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) | Palmitoyl-CoA + L-Serine <=> 3-Dehydrosphinganine + CoA + CO2 | C00154 + C00065 <=> C02934 + C00010 + C00011 | irev | Forward | c | YALI0C03179g OR YALI0F15345g | 2.3.1.50 |  |  | Sphingolipid metabolism |  |  |  |  |  | IKU-IKReaction | n-1-1
R0694 | R02976 | ATP:sphinganine 1-phosphotransferase | ATP:sphinganine 1-phosphotransferase | ATP + Sphinganine <=> ADP + Sphinganine 1-phosphate | C00002 + C00836 <=> C00008 + C01120 | irev | Forward | c | YALI0B11154g | 2.7.1.91 |  |  | Sphingolipid metabolism |  |  |  |  |  | K-KReaction | 1-1-n
R0696 | R02978 | Sphinganine:NADP+ 3-oxidoreductase | Sphinganine:NADP+ 3-oxidoreductase | Sphinganine + NADP+ <=> 3-Dehydrosphinganine + NADPH + H+ | C00836 + C00006 <=> C02934 + C00005 + C00080 | irev | Backward | c | YALI0B17688g | 1.1.1.102 |  |  | Sphingolipid metabolism |  |  |  |  | added manually
R0697 | R06525 | Sphinganine, NADPH: oxygen oxidoreductase (4-hydroxylating) | Sphinganine, NADPH: oxygen oxidoreductase (4-hydroxylating) | Sphinganine + NADPH + H+ + Oxygen <=> Phytosphingosine + NADP+ + H2O | C00836 + C00005 + C00080 + C00007 <=> C12144 + C00006 + C00001 | irev | Forward | c | YALI0E17347g |  |  |  | Sphingolipid metabolism
R0698 |  | Ceramide-1 synthase (26C) | Ceramide-1 synthase (26C) | hexccoa + sphgn --> cer1_26 + coa + h |  | irev | Forward | c | [NAME] | 2.3.1.24 | sphingosine N-acyltransferase |  | Sphingolipid metabolism |  |  |  |  | Acts on sphingosine or its 2-epimer. | IKU-IKReaction | 1-1-n
R0699 |  | Ceramide-1 synthase (24C) | Ceramide-1 synthase (24C) | sphgn + ttccoa --> cer1_24 + coa + h |  | irev | Forward | c | [NAME] | 2.3.1.24 | sphingosine N-acyltransferase |  | Sphingolipid metabolism |  |  |  |  | Acts on sphingosine or its 2-epimer. | IKU-IKReaction | 1-1-n
R0700 |  | Ceramide-2 synthase (24C) | Ceramide-2 synthase (24C) | psphings + ttccoa --> cer2_24 + coa + h |  | irev | Forward | c | [NAME] | 2.3.1.24 | sphingosine N-acyltransferase |  | Sphingolipid metabolism |  |  |  |  | Acts on sphingosine or its 2-epimer. | IKU-IKReaction | 1-1-n
R0701 |  | Ceramide-2 synthase (26C) | Ceramide-2 synthase (26C) | hexccoa + psphings --> cer2_26 + coa + h |  | irev | Forward | c | [NAME] | 2.3.1.24 | sphingosine N-acyltransferase |  | Sphingolipid metabolism |  |  |  |  | Acts on sphingosine or its 2-epimer. | IKU-IKReaction | 1-1-n
R0702 |  | Ceramide-1 hydroxylase (26C) | Ceramide-1 hydroxylase (26C) | cer1_26 + h + nadph + o2 --> cer2_26 + h2o + nadp |  | irev | Forward | c | YALI0E17347g |  |  |  | Sphingolipid metabolism
R0703 |  | Ceramide-1 hydroxylase (24C) | Ceramide-1 hydroxylase (24C) | cer1_24 + h + nadph + o2 --> cer2_24 + h2o + nadp |  | irev | Forward | c | YALI0E17347g |  |  |  | Sphingolipid metabolism
R0704 |  | Ceramide-3 synthase (26C) | Ceramide-3 synthase (26C) | cer2_26 + h + nadph + o2 --> cer3_26 + h2o + nadp |  | irev | Forward | c | YALI0E17347g |  |  |  | Sphingolipid metabolism
R0705 |  | Ceramide-3 synthase (24C) | Ceramide-3 synthase (24C) | cer2_24 + h + nadph + o2 --> cer3_24 + h2o + nadp |  | irev | Forward | c | YALI0E17347g |  |  |  | Sphingolipid metabolism
[NAME] |  | Inositol phosphorylceramide synthase (ceramide-1, 24C), yeast-specific | Inositol phosphorylceramide synthase (ceramide-1, 24C), yeast-specific | cer1_24 + (0.01) ptd1ino_SC --> (0.01) 12dgr_SC + (0.01) ipc124_SC |  | irev | Forward | c | YALI0D06237g |  |  |  | Sphingolipid metabolism
R0707 |  | Inositol phosphorylceramide synthase (ceramide-1, 26C), yeast-specific | Inositol phosphorylceramide synthase (ceramide-1, 26C), yeast-specific | cer1_26 + (0.01) ptd1ino_SC --> (0.01) 12dgr_SC + (0.01) ipc126_SC |  | irev | Forward | c | YALI0D06237g |  |  |  | Sphingolipid metabolism
R0708 |  | Inositol phosphorylceramide synthase (ceramide-2, 24C), yeast-specific | Inositol phosphorylceramide synthase (ceramide-2, 24C), yeast-specific | cer2_24 + (0.01) ptd1ino_SC --> (0.01) 12dgr_SC + (0.01) ipc224_SC |  | irev | Forward | c | YALI0D06237g |  |  |  | Sphingolipid metabolism
R0709 |  | Inositol phosphoryceramide synthase (ceramide-2, 26C), yeast-specific | Inositol phosphoryceramide synthase (ceramide-2, 26C), yeast-specific | cer2_26 + (0.01) ptd1ino_SC --> (0.01) 12dgr_SC + (0.01) ipc226_SC |  | irev | Forward | c | YALI0D06237g |  |  |  | Sphingolipid metabolism
R0710 |  | Inositol phosphorylceramide synthase (ceramide-3, 24C), yeast-specific | Inositol phosphorylceramide synthase (ceramide-3, 24C), yeast-specific | cer3_24 + (0.01) ptd1ino_SC --> (0.01) 12dgr_SC + (0.01) ipc324_SC |  | irev | Forward | c | YALI0D06237g |  |  |  | Sphingolipid metabolism
R0711 |  | Inositol phosphorylceramide synthase (ceramide-3, 26C), yeast-specific | Inositol phosphorylceramide synthase (ceramide-3, 26C), yeast-specific | cer3_26 + (0.01) ptd1ino_SC --> (0.01) 12dgr_SC + (0.01) ipc326_SC |  | irev | Forward | c | YALI0D06237g |  |  |  | Sphingolipid metabolism
R0712 |  | mannose-inositiol phophorylceramide synthase (ceramide-1, 24C), yeast-specific | mannose-inositiol phophorylceramide synthase (ceramide-1, 24C), yeast-specific | gdpmann + (0.01) ipc124_SC --> gdp + h + (0.01) mipc124_SC |  | irev | Forward | c | YALI0F07260g AND YALI0F16093g |  |  |  | Sphingolipid metabolism
R0713 |  | mannose-inositol phosphorylceramide synthase (ceramide-1, 26C), yeast-specific | mannose-inositol phosphorylceramide synthase (ceramide-1, 26C), yeast-specific | gdpmann + (0.01) ipc126_SC --> gdp + h + (0.01) mipc126_SC |  | irev | Forward | c | YALI0F07260g AND YALI0F16093g |  |  |  | Sphingolipid metabolism
R0714 |  | mannose-inositol phosphorylceramide synthase (ceramide-2, 24C), yeast-specific | mannose-inositol phosphorylceramide synthase (ceramide-2, 24C), yeast-specific | gdpmann + (0.01) ipc224_SC --> gdp + h + (0.01) mipc224_SC |  | irev | Forward | c | YALI0F07260g AND YALI0F16093g |  |  |  | Sphingolipid metabolism
R0715 |  | mannose-inositol phosphorylceramide synthase (ceramide-2, 26C), yeast-specific | mannose-inositol phosphorylceramide synthase (ceramide-2, 26C), yeast-specific | gdpmann + (0.01) ipc226_SC --> gdp + h + (0.01) mipc226_SC |  | irev | Forward | c | YALI0F07260g AND YALI0F16093g |  |  |  | Sphingolipid metabolism
R0716 |  | mannose-inositol phosphorylceramide synthase (ceramide-3, 24C), yeast-specific | mannose-inositol phosphorylceramide synthase (ceramide-3, 24C), yeast-specific | gdpmann + (0.01) ipc324_SC --> gdp + h + (0.01) mipc324_SC |  | irev | Forward | c | YALI0F07260g AND YALI0F16093g |  |  |  | Sphingolipid metabolism
R0717 |  | mannose-inositol phosphorylceramide synthase (ceramide-3, 26C), yeast-specific | mannose-inositol phosphorylceramide synthase (ceramide-3, 26C), yeast-specific | gdpmann + (0.01) ipc326_SC --> gdp + h + (0.01) mipc326_SC |  | irev | Forward | c | YALI0F07260g AND YALI0F16093g |  |  |  | Sphingolipid metabolism
R0718 |  | mannose-(inositol-P)2-ceramide synthase (ceramide-1, 24C), yeast-specific | mannose-(inositol-P)2-ceramide synthase (ceramide-1, 24C), yeast-specific | (0.01) mipc124_SC + (0.01) ptd1ino_SC --> (0.01) 12dgr_SC + (0.01) mip2c124_SC |  | irev | Forward | c | [NAME] |  |  |  | Sphingolipid metabolism
R0719 |  | mannose-(inositol-P)2-ceramide synthase (ceramide-1, 26C), yeast-specific | mannose-(inositol-P)2-ceramide synthase (ceramide-1, 26C), yeast-specific | (0.01) mipc126_SC + (0.01) ptd1ino_SC --> (0.01) 12dgr_SC + (0.01) [NAME] |  | irev | Forward | c | [NAME] |  |  |  | Sphingolipid metabolism
R0720 |  | mannose-(inositol-P)2-ceramide synthase (ceramide-2, 26C), yeast specific | mannose-(inositol-P)2-ceramide synthase (ceramide-2, 26C), yeast specific | (0.01) mipc224_SC + (0.01) ptd1ino_SC --> (0.01) 12dgr_SC + (0.01) mip2c224_SC |  | irev | Forward | c | [NAME] |  |  |  | Sphingolipid metabolism
R0721 |  | mannose-(inositol-P)2-ceramide synthase (ceramide-2, 24C), yeast-specific | mannose-(inositol-P)2-ceramide synthase (ceramide-2, 24C), yeast-specific | (0.01) mipc226_SC + (0.01) ptd1ino_SC --> (0.01) 12dgr_SC + (0.01) [NAME] |  | irev | Forward | c | [NAME] |  |  |  | Sphingolipid metabolism
R0722 |  | mannose-(inositol-P)2-ceramide synthase (ceramide-3, 24C), yeast specific | mannose-(inositol-P)2-ceramide synthase (ceramide-3, 24C), yeast specific | (0.01) mipc324_SC + (0.01) ptd1ino_SC --> (0.01) 12dgr_SC + (0.01) mip2c324_SC |  | irev | Forward | c | [NAME] |  |  |  | Sphingolipid metabolism
R0723 |  | mannose-(inositol-P)2-ceramide synthase (ceramide-3, 26C), yeast-specific | mannose-(inositol-P)2-ceramide synthase (ceramide-3, 26C), yeast-specific | (0.01) mipc326_SC + (0.01) ptd1ino_SC --> (0.01) 12dgr_SC + (0.01) mip2c326_SC |  | irev | Forward | c | [NAME] |  |  |  | Sphingolipid metabolism
R0724 |  | alpha,alpha-trehalose glucohydrolase | alpha,alpha-trehalose glucohydrolase | alpha,alpha-Trehalose + H2O <=> 2 alpha-D-Glucose | C01083 + C00001 <=> 2 C00267 | irev | Forward | c | YALI0D15598g | 3.2.1.28 | alpha,alpha-trehalase |  | Starch and sucrose metabolism |  |  | Unreviewed |  |  | IKU-IU-noECnoReaction | 1-1-1
R0725 | R00026 | cellobiose glucohydrolase | cellobiose glucohydrolase | Cellobiose + H2O <=> 2 beta-D-Glucose | C00185 + C00001 <=> 2 C00221 | irev | Forward | c | YALI0F01672g | 3.2.1.21 | hypothetical protein |  | Starch and sucrose metabolism |  |  |  |  | Wide specificity for beta-D-glucosides.Some examples also hydrolyze one or more of the following: beta-D- galactosides, alpha-L-arabinosides, beta-D-xylosides and beta-D- fucosides. | IKU-IKReaction | 1-1-n
[NAME] | R00292 | UDP-glucose:glycogen 4-alpha-D-glucosyltransferase | UDP-glucose:glycogen 4-alpha-D-glucosyltransferase | UDP-glucose <=> UDP + Amylose | C00029 <=> C00015 + C00718 | irev | Forward | c | YALI0F18502g | 2.4.1.11 | hypothetical protein |  | Starch and sucrose metabolism |  |  |  |  | The description (official name) varies according to the source of the enzyme and the nature of its synthetic product.Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin.The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186.A similar enzyme utilizes ADP-glucose (cf. EC 2.4.1.21). | IKU-IKReaction | 1-1-1
R0727 | R00802 | sucrose alpha-glucohydrolase | sucrose alpha-glucohydrolase | Sucrose + H2O <=> beta-D-Fructose + alpha-D-Glucose | C00089 + C00001 <=> C02336 + C00267 | irev | Forward | c | YALI0E26719g | 3.2.1.26 | invertase |  | Starch and sucrose metabolism |  |  | Unreviewed |  | Substrates include sucrose.Also catalyzes fructotransferase reactions. | IKU-IKReaction | 1-1-n
R0728 | R01790 | 1,4-alpha-D-Glucan glucohydrolase | 1,4-alpha-D-Glucan glucohydrolase | Starch + H2O <=> alpha-D-Glucose | C00369 + C00001 <=> C00267 | irev | Forward | c | YALI0E05203g | 3.2.1.3 | hypothetical protein |  | Starch and sucrose metabolism |  |  |  |  | Most forms of the enzyme can rapidly hydrolyze 1,6-alpha-D-glucosidic bonds when the next bond in the sequence is 1,4, and some preparations of this enzyme hydrolyze 1,6- and 1,3-alpha-D-glucosidic bonds in other polysaccharides.This entry covers all such enzymes acting on polysaccharides more rapidly than on oligosaccharides.EC 3.2.1.20 from mammalian intestine can catalyze similar reactions. | IKU-IKReaction | 1-1-n
R0731 | R02110 | 1,4-alpha-D-Glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase | 1,4-alpha-D-Glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase | Amylose <=> Starch | C00718 <=> C00369 | irev | Forward | c | YALI0C06798g | 2.4.1.18 | hypothetical protein | 1,4-alpha-glucan-branching enzyme | Starch and sucrose metabolism |  | Glycan biosynthesis glycogen biosynthesis. | Reviewed |  | Converts amylose into amylopectin.The description (official name) requires a qualification depending on the product, glycogen or amylopectin, e.g. glycogen branching enzyme, amylopectin branching enzyme.The latter has frequently been termed Q-enzyme. Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain. | IKU-IKUReaction | 1-1-1
R0732 |  | 1,4-alpha-D-Glucan:orthophosphate alpha-D-glucosyltransferase | 1,4-alpha-D-Glucan:orthophosphate alpha-D-glucosyltransferase | [NAME] <=> D-Glucose 1-phosphate | C00369 + C00009 <=> C00103 | irev | Forward | c | YALI0F04169g | 2.4.1.1 | hypothetical protein | Phosphorylase | Starch and sucrose metabolism | Pyridoxal phosphate (By similarity). |  | Unreviewed |  | The description (official name) should be qualified in each instance by adding the name of the natural substance, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. | IKU-IKUReaction | 1-1-1
R0733 | R02737 | UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase | UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase | UDP-glucose + alpha-D-Glucose 6-phosphate <=> UDP + alpha,alpha'-Trehalose 6-phosphate | C00029 + C00668 <=> C00015 + C00689 | irev | Forward | c | YALI0D14476g OR YALI0E14685g OR YALI0E31086g | 2.4.1.15 |  |  | Starch and sucrose metabolism |  |  |  |  | See also EC 2.4.1.36. | IKU-IKUReaction | n-1-1
R0734 | R02778 | Trehalose-6-phosphate phosphohydrolase | Trehalose-6-phosphate phosphohydrolase | alpha,alpha'-Trehalose 6-phosphate + H2O <=> alpha,alpha-Trehalose + Orthophosphate | C00689 + C00001 <=> C01083 + C00009 | irev | Forward | c | YALI0D14476g | 3.1.3.12 | trehalose 6-phosphatase |  | Starch and sucrose metabolism |  |  | Unreviewed |  |  | IKU-IKReaction | 1-n-n
R0735 | R02887 | 1,4-beta-D-Glucan glucohydrolase | 1,4-beta-D-Glucan glucohydrolase | Cellulose + H2O <=> beta-D-Glucose | C00760 + C00001 <=> C00221 | irev | Forward | c | YALI0F01672g | 3.2.1.21 | hypothetical protein |  | Starch and sucrose metabolism |  |  |  |  | Wide specificity for beta-D-glucosides.Some examples also hydrolyze one or more of the following: beta-D- galactosides, alpha-L-arabinosides, beta-D-xylosides and beta-D- fucosides. | IKU-IKReaction | 1-1-n
R0736 | R03115 | 1,3-beta-Glucan glucohydrolase | 1,3-beta-Glucan glucohydrolase | 1,3-beta-D-Glucan + H2O <=> alpha-D-Glucose | C00965 + C00001 <=> C00267 | irev | Forward | c | YALI0B03564g OR YALI0F05390g | 3.2.1.58 |  |  | Starch and sucrose metabolism |  |  |  |  | Acts on oligosaccharides, but very slowly on laminaribiose. | IKU-IKReaction | n-1-1
R0738 | R03118 | UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase | UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase | UDP-glucose <=> UDP + 1,3-beta-D-Glucan | C00029 <=> C00015 + C00965 | irev | Forward | c | YALI0C01411g OR YALI0E21021g | 2.4.1.34 |  |  | Starch and sucrose metabolism |  |  |  |  |  | IKU-IKReaction | n-1-1
R0741 | R03921 | Sucrose 6-phosphate fructohydrolase | Sucrose 6-phosphate fructohydrolase | Sucrose 6-phosphate + H2O <=> beta-D-Fructose + alpha-D-Glucose 6-phosphate | C16688 + C00001 <=> C02336 + C00668 | r |  | c | YALI0E26719g | 3.2.1.26 |  | invertase | Starch and sucrose metabolism |  |  | Unreviewed |  | Substrates include sucrose.Also catalyzes fructotransferase reactions. | IKU-IKReaction | 1-1-n
[NAME] | R07494 | NO NAME | NO NAME | 4alpha-Methylzymosterol-4-carboxylate + NADP+ <=> 3-Keto-4-methylzymosterol + NADPH + H+ + CO2 | C15808 + C00006 <=> C15816 + C00005 + C00080 + C00011 | irev | Forward | c | YALI0C22165g | 1.1.1.170 | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating |  | Steroid biosynthesis |  |  |  |  | Also acts on 3-beta-hydroxy-5-alpha-cholest-7-ene-4-alpha- carboxylate. | IKU-IKReaction | 1-1-1
R0743 | R07495 | 4alpha-methylzymosterol:NADP+ 3-oxidoreductase | 4alpha-methylzymosterol:NADP+ 3-oxidoreductase | 3-Keto-4-methylzymosterol + NADPH + H+ <=> 4-alpha-Methylzymosterol + NADP+ | C15816 + C00005 + C00080 <=> C05103 + C00006 | irev | Forward | c | YALI0B17644g | 1.1.1.270 | hypothetical protein | 3-keto-steroid reductase | Steroid biosynthesis |  | Steroid biosynthesis zymosterol biosynthesis zymosterol from lanosterol: step 5/6. | Reviewed |  |  | IKU-IKUReaction | 1-1-1
R0744 | R05640 | Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) | Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) | Lanosterol + 3 Oxygen + 3 NADPH + 3 H+ <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + Formate + 3 NADP+ + 4 H2O | C01724 + 3 C00007 + 3 C00005 + 3 C00080 <=> C11455 + C00058 + 3 C00006 + 4 C00001 | irev | Forward | c | YALI0B05126g | 1.14.13.70 | Sterol 14-alpha demethylase |  | Steroid biosynthesis | Heme-thiolate. |  |  |  | The enzyme (P450) catalyzes successive hydroxylations of the 14-alpha-methyl group and C-15, followed by elimination as formate leaving the 14(15) double bond.This enzyme acts on a range of steroids with a 14-alpha-methyl group. | IKU-IKReaction | 1-1-n
R0746 | R07509 | NO NAME | NO NAME | 14-Demethyllanosterol + 3 NADPH + 3 H+ + 3 Oxygen <=> 4alpha-Methylzymosterol-4-carboxylate + 3 NADP+ + 4 H2O | C05108 + 3 C00005 + 3 C00080 + 3 C00007 <=> C15808 + 3 C00006 + 4 C00001 | irev | Forward | c | [NAME] | 1.14.13.72 | C-4 methylsterol oxidase |  | Steroid biosynthesis |  |  |  |  | Requires cytochrome b5.Also acts on 4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol.The sterol can be based on cycloartenol as well as lanosterol.Formerly EC 1.14.99.16. | IKU-IKReaction | 1-1-1
R0747 | R02874 | Squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing) | Squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing) | [NAME] H+ <=> (S)-2,3-Epoxysqualene + NADP+ + H2O | C00751 + C00007 + C00005 + C00080 <=> C01054 + C00006 + C00001 | irev | Forward | r | YALI0E15730g | 1.14.13.132 | squalene monooxygenase |  | Steroid biosynthesis | FAD. |  |  |  | This enzyme, together with EC 5.4.99.7, was formerly known as squalene oxidocyclase.Formerly EC 1.14.1.3 and EC 1.99.1.13. | IKU-IKReaction | 1-1-1
R0748 | R05639 | 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase | 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase | 14-Demethyllanosterol + NADP+ <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ | C05108 + C00006 <=> C11455 + C00005 + C00080 | irev | Backward | c | YALI0B23298g | 1.3.1.70 | Delta(14)=-sterol reductase |  | Steroid biosynthesis |  |  |  |  | Acts on a range of steroids with a 14(15)-double bond. | IKU-IKReaction | 1-1-n
R0750 | R05641 | ergosterol:NADP+ D24(241)-oxidoreductase | ergosterol:NADP+ D24(241)-oxidoreductase | [NAME] <=> Ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+ | C01694 + C00006 <=> C05440 + C00005 + C00080 | irev | Backward | r | YALI0D19206g | 1.3.1.71 | Delta(24(24(1=-sterol reductase) |  | Steroid biosynthesis |  |  |  |  | Acts on a range of steroids with a 24(24(1))-double bond. | IKU-IKReaction | 1-1-1
R0751 | R04427 | S-Adenosyl-L-methionine:zymosterol C-methyltransferase | S-Adenosyl-L-methionine:zymosterol C-methyltransferase | S-Adenosyl-L-methionine + Zymosterol <=> S-Adenosyl-L-homocysteine + Fecosterol | C00019 + C05437 <=> C00021 + C04525 | irev | Forward | c | YALI0F08701g | 2.1.1.41 | sterol 24-C-methyltransferase | Sterol 24-C-methyltransferase | Steroid biosynthesis | Glutathione. | Steroid metabolism ergosterol biosynthesis ergosterol from zymosterol: step 1/5. | Reviewed |  | Acts on a range of sterols with a 24(25)-double bond in the side chain.While zymosterol is the preferred substrate it also acts on desmosterol, 5-alpha-cholesta-7,24-dien-3-beta-ol, 5-alpha-cholesta- 5,7,24-trien-3-beta-ol, 4-alpha-methylzymosterol and others.S-adenosyl-L-methionine attacks the Si face of the 24(25) double bond and the C-24 hydrogen is transferred to C-25 on the Re face of the double bond. | IKU-IKUReaction | 1-1-n
R0754 | R03199 | (S)-2,3-Epoxysqualene mutase (cyclizing, lanosterol-forming) | (S)-2,3-Epoxysqualene mutase (cyclizing, lanosterol-forming) | (S)-2,3-Epoxysqualene <=> Lanosterol | C01054 <=> C01724 | irev | Forward | c | YALI0F04378g | 5.4.99.7 | hypothetical protein |  | Steroid biosynthesis |  |  |  |  | Formerly EC 1.14.1.3 and EC 1.99.1.13. | IKU-IKReaction | 1-1-1
R0755 | R06223 | squalene synthase | squalene synthase | 2 trans,trans-Farnesyl diphosphate + NADPH + H+ <=> Squalene + 2 Diphosphate + NADP+ | 2 C00448 + C00005 + C00080 <=> C00751 + 2 C00013 + C00006 | irev | Forward | c | YALI0A10076g | 2.5.1.21 | farnesyl-diphosphate farnesyltransferase | Squalene synthase | Steroid biosynthesis | Magnesium | Terpene metabolism lanosterol biosynthesis lanosterol from farnesyl diphosphate: step 1/3. | Reviewed | Endoplasmic reticulum membrane Multi-pass membrane protein (By similarity). | This microsomal enzyme catalyzes the first committed step in the biosynthesis of sterols.In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated.When [NAME] is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP).High concentrations of FPP inhibit the production of squalene but not of PSPP. | IKU-IKUReaction | 1-1-n
R0756 | [NAME] | NO NAME | NO NAME | 4alpha-Methylzymosterol <=> Zymosterol | C05103 <=> C05437 | irev | Forward | c |  |  |  |  | Steroid biosynthesis
R0757 | R07497 | NO NAME | NO NAME | Fecosterol <=> Episterol | C04525 <=> C15777 | irev | Forward | c | YALI0B17204g OR YALI0E32065g |  |  |  | Steroid biosynthesis
R0758 | R07505 | NO NAME | NO NAME | Episterol + NADP+ <=> 5,7,24(28)-Ergostatrienol + NADPH + H+ | C15777 + C00006 <=> C15778 + C00005 + C00080 | irev | Forward | c | YALI0D20878g | 1.14.21.6 |  |  | Steroid biosynthesis
R0759 | R07506 | NO NAME | NO NAME | 5,7,24(28)-Ergostatrienol + NADP+ <=> Ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+ | C15778 + C00006 <=> C05440 + C00005 + C00080 | irev | Forward | c | YALI0A18062g |  |  |  | Steroid biosynthesis
R0760 | R01121 | ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming); ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating) | ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating) | ATP + (R)-5-Diphosphomevalonate <=> ADP + Orthophosphate + Isopentenyl diphosphate + CO2 | C00002 + C01143 <=> C00008 + C00009 + C00129 + C00011 | irev | Forward | c | YALI0F05632g | 4.1.1.33 | diphosphomevalonate decarboxylase |  | Terpenoid backbone biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0761 | R01123 | Isopentenyl-diphosphate delta3-delta2-isomerase | Isopentenyl-diphosphate delta3-delta2-isomerase | Isopentenyl diphosphate <=> Dimethylallyl diphosphate | C00129 <=> C00235 | r |  | c | YALI0F04015g | 5.3.3.2 | isopentenyl-diphosphate delta-isomerase |  | Terpenoid backbone biosynthesis | FMN or FAD; [NAME] or manganese or calcium. |  |  |  |  | IKU-IKReaction | 1-1-1
R0762 | R01658 | Dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase | Dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase | Dimethylallyl diphosphate + Isopentenyl diphosphate <=> Diphosphate + Geranyl diphosphate | C00235 + C00129 <=> C00013 + C00341 | irev | Forward | c | YALI0D17050g OR YALI0E05753g | 2.5.1.1 |  |  | Terpenoid backbone biosynthesis |  |  |  |  | Will not accept larger prenyl diphosphates as efficient donors. | IKU-IKReaction | n-n-n
R0763 | R02003 | Geranyl-diphosphate:isopentenyl-diphosphate geranyltrans-transferase | Geranyl-diphosphate:isopentenyl-diphosphate geranyltrans-transferase | Geranyl diphosphate + Isopentenyl diphosphate <=> Diphosphate + trans,trans-Farnesyl diphosphate | C00341 + C00129 <=> C00013 + C00448 | irev | Forward | c | YALI0D17050g OR YALI0E05753g | 2.5.1.10 |  |  | Terpenoid backbone biosynthesis |  |  |  |  | Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate.The enzyme will not accept larger prenyl diphosphates as efficient donors. | IKU-IKReaction | n-n-n
R0764 | R02061 | trans,trans-Farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase | trans,trans-Farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase | trans,trans-Farnesyl diphosphate + Isopentenyl diphosphate <=> Diphosphate + Geranylgeranyl diphosphate | [NAME] C00129 <=> C00013 + C00353 | irev | Forward | c | YALI0D17050g | 2.5.1.29 | hypothetical protein |  | Terpenoid backbone biosynthesis |  |  | Unreviewed |  | Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors. | IKU-IKReaction | 1-1-1
R0765 | R02082 | (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) | (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) | (R)-Mevalonate + CoA + 2 NADP+ <=> (S)-3-Hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | [NAME] C00006 <=> C00356 + 2 C00005 + 2 C00080 | irev | Backward | c | YALI0E04807g | 1.1.1.34 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |  | Terpenoid backbone biosynthesis |  |  |  |  | The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47. | IKU-IKReaction | 1-1-1
R0766 | R02245 | ATP:(R)-mevalonate 5-phosphotransferase | ATP:(R)-mevalonate 5-phosphotransferase | ATP + (R)-Mevalonate <=> ADP + (R)-5-Phosphomevalonate | C00002 + C00418 <=> C00008 + C01107 | irev | Forward | c | YALI0B16038g | 2.7.1.36 | mevalonate kinase |  | Terpenoid backbone biosynthesis |  |  |  |  | CTP, GTP and UTP can also act as donors. | IKU-IKReaction | 1-1-1
[NAME] | R03245 | ATP:(R)-5-phosphomevalonate phosphotransferase | ATP:(R)-5-phosphomevalonate phosphotransferase | ATP + (R)-5-Phosphomevalonate <=> ADP + (R)-5-Diphosphomevalonate | C00002 + C01107 <=> C00008 + C01143 | irev | Forward | c | YALI0E06193g | 2.7.4.2 | phosphomevalonate kinase |  | Terpenoid backbone biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0768 | R05556 | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10-55 isopentenyl units) | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10-55 isopentenyl units) | trans,trans-Farnesyl diphosphate + Isopentenyl diphosphate <=> [NAME] diphosphate + Diphosphate | [NAME] C00129 <=> C05859 + C00013 | irev | Forward | c | YALI0C18799g OR YALI0D17556g | 2.5.1.87 |  |  | Terpenoid backbone biosynthesis |  |  |  |  | The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated alpha-isoprene unit, which serves as a glycosyl carrier in protein glycosylation.The yeast Saccharomyces cerevisiae has two different enzymes that catalyze this reaction.Rer2p synthesizes a well-defined family of polyprenols of 13-18 isoprene residues with dominating C(80) (16 isoprene residues) extending to C(120), while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits.Largest Srt1p products reach C(290).The enzyme from Arabidopsis thaliana catalyzes the formation of polyprenyl diphosphates with predominant carbon number C(120). | IKU-differenceReaction | n-1-1
R0769 | R09245 | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units) | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units) | trans,trans-Farnesyl diphosphate + 3 Isopentenyl diphosphate <=> all-trans-Hexaprenyl diphosphate + 3 Diphosphate | C00448 + 3 C00129 <=> C01230 + 3 C00013 | irev | Forward | c | YALI0C18755g | 2.5.1.83 | hypothetical protein | Probable hexaprenyl pyrophosphate synthase, mitochondrial | Terpenoid backbone biosynthesis |  | Cofactor biosynthesis ubiquinone biosynthesis. | Reviewed | Mitochondrion (By similarity). | The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate.Formerly EC 2.5.1.33. | IKU-IKReaction | 1-n-n
R0770 | R09246 | geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units) | geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units) | Geranylgeranyl diphosphate + 2 Isopentenyl diphosphate <=> all-trans-Hexaprenyl diphosphate + 2 Diphosphate | C00353 + 2 C00129 <=> C01230 + 2 C00013 | irev | Forward | c | YALI0C18755g | 2.5.1.82 | hypothetical protein | Probable hexaprenyl pyrophosphate synthase, mitochondrial | Terpenoid backbone biosynthesis | Magnesium. | Cofactor biosynthesis ubiquinone biosynthesis. | Reviewed | Mitochondrion (By similarity). | The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate.Formerly EC 2.5.1.33. | IKU-IKReaction | 1-n-n
R0771 | R01978 | acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) | acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) | (S)-3-Hydroxy-3-methylglutaryl-CoA + CoA <=> Acetyl-CoA + H2O + Acetoacetyl-CoA | C00356 + C00010 <=> C00024 + C00001 + C00332 | irev | Backward | c | YALI0F30481g | 2.3.3.10 | hypothetical protein |  | Synthesis and degradation of ketone bodies |  |  |  |  | Formerly EC 4.1.3.5. | IKU-IKReaction | 1-1-1
R0772 | R00238 | Acetyl-CoA:acetyl-CoA C-acetyltransferase | Acetyl-CoA:acetyl-CoA C-acetyltransferase | 2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA | 2 C00024 <=> C00010 + C00332 | irev | Forward | m | YALI0B08536g OR YALI0E11099g | 2.3.1.9 | acetyl-CoA acetyltransferase | Acetyl-CoA acetyltransferase | Synthesis and degradation of ketone bodies |  |  | Reviewed OR Unreviewed | Peroxisome. |  | IKU-IKReaction | n-1-n
R0773 | R01360 | (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming) | (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming) | (S)-3-Hydroxy-3-methylglutaryl-CoA <=> Acetyl-CoA + Acetoacetate | C00356 <=> C00024 + C00164 | irev | Forward | c | YALI0B22550g | 4.1.3.4 | hydroxymethylglutaryl-CoA lyase |  | Synthesis and degradation of ketone bodies |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0774 | R00410 | succinyl-CoA:acetoacetate CoA-transferase | succinyl-CoA:acetoacetate CoA-transferase | Succinyl-CoA + Acetoacetate <=> Succinate + Acetoacetyl-CoA | C00091 + C00164 <=> C00042 + C00332 | r |  | c | [NAME] | 2.8.3.5 | hypothetical protein |  | Synthesis and degradation of ketone bodies |  |  | Unreviewed |  | Acetoacetate or, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptor.Malonyl-CoA can act instead of succinyl-CoA. | IKU-IKReaction | 1-1-1
R0775 | R01682 | 3-Sulfo-L-alanine carboxy-lyase (taurine-forming) | 3-Sulfo-L-alanine carboxy-lyase (taurine-forming) | L-Cysteate <=> Taurine + CO2 | C00506 <=> C00245 + C00011 | irev | Forward | c | YALI0F08415g | 4.1.1.15 | glutamate decarboxylase |  | Taurine and hypotaurine metabolism | Pyridoxal 5'-phosphate. |  |  |  | The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate. | IKU-IKReaction | 1-1-n
R0777 | R02466 | 3-Sulfino-L-alanine carboxy-lyase | 3-Sulfino-L-alanine carboxy-lyase | 3-Sulfino-L-alanine <=> Hypotaurine + CO2 | C00606 <=> C00519 + C00011 | irev | Forward | c | YALI0F08415g | 4.1.1.15 | glutamate decarboxylase |  | Taurine and hypotaurine metabolism | Pyridoxal 5'-phosphate. |  |  |  | The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate. | IKU-IKReaction | 1-1-n
R0778 | R02434 | NO NAME | NO NAME | L-Cysteate + NADH + H+ <=> 3-Sulfino-L-alanine + H2O + NAD+ | C00506 + C00004 + C00080 <=> C00606 + C00001 + C00003 | irev | Backward | c |  |  |  |  | Taurine and hypotaurine metabolism |  |  |  |  | spontaneous reaction
R0779 | R00344 | Pyruvate:carbon-dioxide ligase (ADP-forming) | Pyruvate:carbon-dioxide ligase (ADP-forming) | ATP + Pyruvate + HCO3- <=> ADP + Orthophosphate + Oxaloacetate | C00002 + C00022 + C00288 <=> C00008 + C00009 + C00036 | irev | Forward | c | [NAME] | 6.4.1.1 | hypothetical protein |  | Citrate cycle (TCA cycle) | Biotin; Zinc or manganese. |  |  |  | The animal enzyme requires acetyl-CoA. | IKU-IKReaction | 1-1-1
R0780 | R00351 | acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing) | acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing) | Citrate + CoA <=> Acetyl-CoA + H2O + Oxaloacetate | C00158 + C00010 <=> C00024 + C00001 + C00036 | irev | Backward | m | YALI0E00638g OR YALI0E02684g | 2.3.3.1 |  |  | Citrate cycle (TCA cycle) |  |  |  |  |  | IKU-IKReaction | n-1-1
R0781 | R00405 | Succinate:CoA ligase (ADP-forming) | Succinate:CoA ligase (ADP-forming) | ATP + Succinate + CoA <=> ADP + Orthophosphate + Succinyl-CoA | C00002 + C00042 + C00010 <=> C00008 + C00009 + C00091 | r |  | m | YALI0D04741g AND [NAME] | 6.2.1.5 |  |  | Citrate cycle (TCA cycle) |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0782 | R00709 | Isocitrate:NAD+ oxidoreductase (decarboxylating) | Isocitrate:NAD+ oxidoreductase (decarboxylating) | Isocitrate + NAD+ <=> 2-Oxoglutarate + CO2 + NADH + H+ | C00311 + C00003 <=> C00026 + C00011 + C00004 + C00080 | irev | Forward | m | YALI0D06303g OR YALI0E05137g | 1.1.1.41 |  |  | Citrate cycle (TCA cycle) |  |  |  |  |  | IKU-IKReaction | n-1-1
R0783 | R01082 | (S)-malate hydro-lyase (fumarate-forming) | (S)-malate hydro-lyase (fumarate-forming) | (S)-Malate <=> Fumarate + H2O | C00149 <=> C00122 + C00001 | r |  | m | YALI0C06776g | 4.2.1.2 | fumarase |  | Citrate cycle (TCA cycle) |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0784 | R02570 | succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase | succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase | Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine | C00091 + C15973 <=> C00010 + C16254 | r |  | m | YALI0E16929g | 2.3.1.61 | 2-oxoglutarate dehydrogenase E2 component |  | Citrate cycle (TCA cycle) |  |  |  |  | A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2 and EC 1.8.1.4.The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalyzed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A. | IKU-IKReaction | 1-1-n
R0785 | R07618 | enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase | enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase | Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+ | C15973 + C00003 <=> C15972 + C00004 + C00080 | r |  | m | YALI0D20768g | 1.8.1.4 | dihydrolipoamide dehydrogenase | Dihydrolipoyl dehydrogenase | Citrate cycle (TCA cycle) | Binds 1 FAD per subunit (By similarity). |  | Unreviewed |  | A component of the multienzyme 2-oxo-acid dehydrogenase complexes.In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12 and catalyzes oxidation of its dihydrolipoyl groups.It plays a similar role in the oxoglutarate and 3-methyl-2- oxobutanoate dehydrogenase complexes.Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts, together with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine.It can also use free dihydrolipoate, dihydrolipoamide or dihydrolipoyllysine as substrate.Was first shown to catalyze the oxidation of NADH by methylene blue; this activity was called diaphorase.The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.Formerly EC 1.6.4.3. | IKU-IKUReaction | 1-1-n
R0786 | R01324 | citrate hydroxymutase | citrate hydroxymutase | Citrate <=> Isocitrate | C00158 <=> C00311 | r |  | m | YALI0D09361g OR YALI0E14949g | 4.2.1.3 |  |  | Citrate cycle (TCA cycle) | Iron-sulfur. |  |  |  | Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate.The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate.Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate. | IKU-IKReaction | n-1-n
R0787 | R00267 | Isocitrate:NADP+ oxidoreductase (decarboxylating) | Isocitrate:NADP+ oxidoreductase (decarboxylating) | Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+ | C00311 + C00006 <=> C00026 + C00011 + C00005 + C00080 | irev | Forward | m | YALI0F04095g | 1.1.1.42 | isocitrate dehydrogenase (NADP) | Isocitrate dehydrogenase [NADP] | Citrate cycle (TCA cycle) | Binds 1 magnesium or manganese ion per subunit (By similarity). |  | Unreviewed |  | Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate.In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm.The enzyme from some species can also use NAD(+) but much more slowly. | IKU-IKUReaction | 1-1-n
R0788 | R01700 | 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) | 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) | 2-Oxoglutarate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | C00026 + C15972 <=> C16254 + C00011 | irev | Forward | m | YALI0E33517g | 1.2.4.2 | 2-oxoglutarate dehydrogenase E1 component |  | Citrate cycle (TCA cycle) | Thiamine diphosphate. |  |  |  | It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, which also binds multiple copies of EC 1.8.1.4.It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61. | IKU-IKReaction | 1-1-n
R0789 | R00408 | Succinate:(acceptor) oxidoreductase | Succinate:(acceptor) oxidoreductase | Succinate + FAD <=> FADH2 + Fumarate | C00042 + C00016 <=> C01352 + C00122 | r |  | m | YALI0A14784g AND YALI0D11374g AND YALI0D23397g AND YALI0E29667g | 1.3.5.1 |  |  | Citrate cycle (TCA cycle) | FAD;Iron-sulfur. |  |  |  | The complex, present in mitochondria, can be degraded to form EC 1.3.99.1, which no longer reacts with ubiquinone. | IKU-IKReaction | n-1-1
R0790 | [NAME] | ATP:pyridoxal 5'-phosphotransferase | ATP:pyridoxal 5'-phosphotransferase | ATP + Pyridoxal <=> ADP + Pyridoxal 5'-phosphate | C00002 + C00250 <=> C00008 + C00018 | irev | Forward | c | [NAME] | 2.7.1.35 | Pyridoxal kinase |  | [NAME] metabolism |  |  |  |  | Pyridoxine, pyridoxamine and various derivatives can also act as acceptors. | IKU-IKReaction | 1-1-n
R0791 | R00277 | Pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating) | Pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating) | Pyridoxamine phosphate + H2O + Oxygen <=> Pyridoxal phosphate + NH3 + Hydrogen peroxide | C00647 + C00001 + C00007 <=> C00018 + C00014 + C00027 | irev | Forward | c | [NAME] | 1.4.3.5 | Pyridoxamine 5'-phosphate oxidase |  | [NAME] metabolism | FMN. |  |  |  | In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5. | IKU-IKReaction | 1-1-n
R0792 | R00278 | Pyridoxine 5-phosphate:oxygen oxidoreductase | Pyridoxine 5-phosphate:oxygen oxidoreductase | Pyridoxine phosphate + Oxygen <=> Hydrogen peroxide + Pyridoxal phosphate | C00627 + C00007 <=> [NAME] | irev | Forward | c | [NAME] | 1.4.3.5 | Pyridoxamine 5'-phosphate oxidase |  | [NAME] metabolism | FMN. |  |  |  | In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5. | IKU-IKReaction | 1-1-n
R0793 | R01708 | Pyridoxine:NADP+ 4-oxidoreductase | Pyridoxine:NADP+ 4-oxidoreductase | Pyridoxine + NADP+ <=> Pyridoxal + NADPH + H+ | C00314 + C00006 <=> C00250 + C00005 + C00080 | r |  | c | [NAME] | 1.1.1.65 | hypothetical protein |  | [NAME] metabolism |  |  |  |  | Also oxidizes pyridoxine phosphate. | IKU-IKReaction | 1-1-1
R0794 | R01710 | Pyridoxamine:oxygen oxidoreductase (deaminating) | Pyridoxamine:oxygen oxidoreductase (deaminating) | Pyridoxamine + H2O + Oxygen <=> Pyridoxal + NH3 + Hydrogen peroxide | C00534 + C00001 + C00007 <=> C00250 + C00014 + C00027 | r |  | c | [NAME] | 1.4.3.5 | Pyridoxamine 5'-phosphate oxidase |  | [NAME] metabolism | FMN. |  |  |  | In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5. | IKU-IKReaction | 1-1-n
R0795 | R01711 | Pyridoxine:oxygen oxidoreductase (deaminating) | Pyridoxine:oxygen oxidoreductase (deaminating) | Pyridoxine + Oxygen <=> Pyridoxal + Hydrogen peroxide | C00314 + C00007 <=> C00250 + C00027 | r |  | c | [NAME] | 1.4.3.5 | Pyridoxamine 5'-phosphate oxidase |  | [NAME] metabolism | FMN. |  |  |  | In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5. | IKU-IKReaction | 1-1-n
R0796 | R01909 | ATP:pyridoxine 5'-phosphotransferase | ATP:pyridoxine 5'-phosphotransferase | ATP + Pyridoxine <=> ADP + Pyridoxine phosphate | C00002 + C00314 <=> C00008 + C00627 | irev | Forward | c | [NAME] | 2.7.1.35 | Pyridoxal kinase |  | [NAME] metabolism |  |  |  |  | pyridoxal, pyridoxamine and various derivatives can also act as acceptors. | IKU-IKReaction | 1-1-n
R0797 | R02493 | ATP:pyridoxal 5'-phosphotransferase | ATP:pyridoxal 5'-phosphotransferase | ATP + Pyridoxamine <=> ADP + Pyridoxamine phosphate | C00002 + C00534 <=> C00008 + C00647 | irev | Forward | c | [NAME] | 2.7.1.35 | Pyridoxal kinase |  | [NAME] metabolism |  |  |  |  | Pyridoxine, pyridoxal and various derivatives can also act as acceptors. | IKU-IKReaction | 1-1-n
R0798 | R05085 | O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase | O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase | O-Phospho-4-hydroxy-L-threonine + 2-Oxoglutarate <=> 2-Oxo-3-hydroxy-4-phosphobutanoate + L-Glutamate | C06055 + C00026 <=> C06054 + C00025 | r |  | c | YALI0F06468g | 2.6.1.52 | hypothetical protein |  | [NAME] metabolism | Pyridoxal 5'-phosphate. |  |  |  | Catalyzes the second step in the phosphorylated pathway of serine biosynthesis in Escherichia coli.Also catalyzes the third step in the biosynthesis of the coenzyme pyridoxal 5'-phosphate in E.coli (using reaction 2 above).In E.coli, pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate).Pyridoxal phosphate is the cofactor for both activities and therefore seems to be involved in its own biosynthesis.Non-phosphorylated forms of serine and threonine are not substrates. | IKU-IKReaction | 1-1-n
R0799 | R05086 | O-Phospho-4-hydroxy-L-threonine phospho-lyase (adding water) | O-Phospho-4-hydroxy-L-threonine phospho-lyase (adding water) | O-Phospho-4-hydroxy-L-threonine + H2O <=> 4-Hydroxy-L-threonine + Orthophosphate | C06055 + C00001 <=> C06056 + C00009 | irev | Forward | c | YALI0F23221g | 4.2.3.1 | L-threonine synthase |  | [NAME] metabolism | Pyridoxal 5'-phosphate. |  |  |  | Formerly EC 4.2.99.2. | IKU-IKReaction | 1-1-n
R0800 | R07456 | NO NAME | NO NAME | D-Glyceraldehyde 3-phosphate + D-Ribulose 5-phosphate + L-Glutamine <=> Pyridoxal phosphate + L-Glutamate | C00118 + C00199 + C00064 <=> C00018 + C00025 | irev | Forward | c | [NAME] AND YALI0C24255g |  |  |  | [NAME] metabolism
R0801 | R01913 | NO NAME | NO NAME | Pyridoxine <=> 1-Deoxy-D-xylulose + 4-Hydroxy-L-threonine | C00314 <=> C06257 + C06056 | irev | Backward | c |  |  |  |  | [NAME] metabolism
R0802 | R00616 | ATP:thiamine-diphosphate phosphotransferase | ATP:thiamine-diphosphate phosphotransferase | ATP + Thiamin diphosphate <=> ADP + Thiamin triphosphate | C00002 + C00068 <=> C00008 + C03028 | irev | Forward | c | YALI0E21351g | 2.7.6.2 | hypothetical protein |  | Thiamine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0803 | R00619 | ATP:thiamine diphosphotransferase | ATP:thiamine diphosphotransferase | ATP + Thiamine <=> AMP + Thiamin diphosphate | C00002 + C00378 <=> C00020 + C00068 | irev | Forward | c | YALI0E21351g | 2.7.6.2 | hypothetical protein |  | Thiamine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0804 | R03223 | 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase | 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase | 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-Methyl-5-(2-phosphoethyl)-thiazole <=> Diphosphate + Thiamin monophosphate | C04752 + C04327 <=> C00013 + C01081 | irev | Forward | c | YALI0C15554g | 2.5.1.3 | hypothetical protein |  | Thiamine metabolism |  |  | Unreviewed |  |  | IKU-IKReaction | 1-n-n
R0805 | R03471 | ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase | ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase | ATP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine <=> ADP + 4-Amino-2-methyl-5-phosphomethylpyrimidine | C00002 + C01279 <=> C00008 + C04556 | irev | Forward | c | YALI0E04224g | 2.7.1.49 | hypothetical protein |  | Thiamine metabolism |  |  | Unreviewed |  | CTP, UTP and GTP can act as donors. | IKU-IU-noECnoReaction | 1-1-n
R0806 | R04448 | ATP:4-methyl-5-(2-hydroxyethyl)-thiazole 2-phosphotransferase | ATP:4-methyl-5-(2-hydroxyethyl)-thiazole 2-phosphotransferase | ATP + 5-(2-Hydroxyethyl)-4-methylthiazole <=> ADP + 4-Methyl-5-(2-phosphoethyl)-thiazole | C00002 + C04294 <=> C00008 + C04327 | irev | Forward | c | YALI0C15554g | 2.7.1.50 | hypothetical protein |  | Thiamine metabolism |  |  | Unreviewed |  |  | IKU-IKReaction | 1-n-n
R0807 | R04509 | ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase | ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase | ATP + 4-Amino-2-methyl-5-phosphomethylpyrimidine <=> ADP + 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate | C00002 + C04556 <=> C00008 + C04752 | irev | Forward | c | YALI0E04224g | 2.7.4.7 | hypothetical protein |  | Thiamine metabolism |  |  | Unreviewed |  |  | IKU-IU-noECnoReaction | 1-1-n
R0809 | R00678 | L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) | L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) | L-Tryptophan + Oxygen <=> L-Formylkynurenine | C00078 + C00007 <=> C02700 | irev | Forward | c | YALI0F26455g | 1.13.11.52 | hypothetical protein |  | Tryptophan metabolism | Heme. |  |  |  | Requires ascorbic acid and methylene blue for activity.Has broader substrate specificity than EC 1.13.11.11.Is induced in response to pathological conditions and host-defense mechanisms.While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan.Superoxide radicals can replace O(2) as oxygen donor. | IKU-IKReaction | 1-1-n
R0810 | R00684 | L-Tryptophan:2-oxoglutarate aminotransferase | L-Tryptophan:2-oxoglutarate aminotransferase | L-Tryptophan + 2-Oxoglutarate <=> Indolepyruvate + L-Glutamate | C00078 + C00026 <=> C00331 + C00025 | irev | Forward | c | YALI0E20977g | 2.6.1.27 | hypothetical protein |  | Tryptophan metabolism | Pyridoxal 5'-phosphate. |  | Unreviewed |  | Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids. | IKU-differenceReaction | 1-n-n
R0813 | R01960 | L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating) | L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating) | L-Kynurenine + Oxygen + NADPH + H+ <=> 3-Hydroxy-L-kynurenine + NADP+ + H2O | [NAME] <=> C03227 + C00006 + C00001 | irev | Forward | c | YALI0D09867g | 1.14.13.9 | Kynurenine 3-monooxygenase | Kynurenine 3-monooxygenase | Tryptophan metabolism | FAD (By similarity). | Cofactor biosynthesis NAD(+) biosynthesis quinolinate from L-kynurenine: step 1/3. | Reviewed | Mitochondrion (By similarity). | Formerly EC 1.14.1.2 and EC 1.99.1.5. | IKU-IKUReaction | 1-1-1
R0814 | R02665 | 3-Hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing) | 3-Hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing) | 3-Hydroxyanthranilate + Oxygen <=> 2-Amino-3-carboxymuconate semialdehyde | C00632 + C00007 <=> C04409 | irev | Forward | c | YALI0B02852g | 1.13.11.6 | 3-hydroxyanthranilate 3,4-dioxygenase | 3-hydroxyanthranilate 3,4-dioxygenase | Tryptophan metabolism | Fe2+ ion | Cofactor biosynthesis NAD(+) biosynthesis quinolinate from L-kynurenine: step 3/3. | Reviewed | Cytoplasm (By similarity). | The product of the reaction spontaneously rearrange to quinolinic acid (quin).Formerly EC 1.13.1.6. | IKU-IKUReaction | 1-1-1
R0815 | [NAME] | 3-Hydroxy-L-kynurenine hydrolase | 3-Hydroxy-L-kynurenine hydrolase | 3-Hydroxy-L-kynurenine + H2O <=> 3-Hydroxyanthranilate + L-Alanine | [NAME] + C00001 <=> C00632 + C00041 | irev | Forward | c | [NAME] | 3.7.1.3 | Kynureninase | Kynureninase | Tryptophan metabolism | Pyridoxal 5'-phosphate. | Cofactor biosynthesis NAD(+) biosynthesis quinolinate from L-kynurenine: step 2/3. | Reviewed | Cytoplasm (By similarity). | Also acts on 3'-hydroxykynurenine and some other (3-arylcarbonyl)-alanines. | IKU-IKUReaction | 1-1-n
R0816 | R02670 | NO NAME | NO NAME | 2 3-Hydroxyanthranilate + 4 Oxygen <=> Cinnavalininate + 2 O2.- + 2 Hydrogen peroxide + 2 H+ | 2 C00632 + 4 C00007 <=> C05640 + 2 C00704 + 2 C00027 + 2 C00080 | irev | Forward | c | YALI0E34265g OR YALI0E34749g OR YALI0F30987g | 1.11.1.6 |  |  | Tryptophan metabolism | Heme; Manganese. |  |  |  | This enzyme can also act as an EC 1.11.1.7 for which several organic substances, especially ethanol, can act as a hydrogen donor.A manganese protein containing [NAME]) in the resting state, which also belongs here, is often called pseudocatalase.Enzymes from some microorganisms, such as Penicillium simplicissimum, which exhibit both catalase and peroxidase activity, have sometimes been referred to as catalase-peroxidase. | IKU-IKUReaction | n-1-n
R0817 | R02678 | Indole-3-acetaldehyde:NAD+ oxidoreductase | Indole-3-acetaldehyde:NAD+ oxidoreductase | Indole-3-acetaldehyde + NAD+ + H2O <=> Indole-3-acetate + NADH + H+ | C00637 + C00003 + C00001 <=> C00954 + C00004 + C00080 | irev | Forward | c | YALI0B01298g OR YALI0C03025g OR YALI0E00264g OR YALI0F23793g | 1.2.1.3 |  |  | Tryptophan metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0821 | R03096 | Indole-3-acetamide amidohydrolase | Indole-3-acetamide amidohydrolase | (Indol-3-yl)acetamide + H2O <=> Indole-3-acetate + NH3 | C02693 + C00001 <=> [NAME] | irev | Forward | c | YALI0E34771g OR YALI0F16401g | 3.5.1.4 |  |  | Tryptophan metabolism |  |  |  |  |  | IKU-IU-noECnoReaction | n-1-n
R0823 | R03664 | L-Tryptophan -tRNA(Trp) ligase (AMP-forming) | L-Tryptophan -tRNA(Trp) ligase (AMP-forming) | ATP + L-Tryptophan + tRNA(Trp) <=> AMP + Diphosphate + L-Tryptophanyl-tRNA(Trp) | C00002 + C00078 + C01652 <=> C00020 + C00013 + C03512 | irev | Forward | c | [NAME]g | 6.1.1.2 |  |  | Tryptophan metabolism |  |  |  |  |  | IKU-IKReaction | n-1-1
R0827 | R04293 | NO NAME | NO NAME | Quinolinate + H2O <=> 2-Amino-3-carboxymuconate semialdehyde | C03722 + C00001 <=> C04409 | irev | Backward | c |  |  |  |  | Tryptophan metabolism |  |  |  |  | spontaneous reaction
R0829 | [NAME] | 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating) | 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating) | 3-(4-Hydroxyphenyl)pyruvate + Oxygen <=> Homogentisate + CO2 | C01179 + C00007 <=> C00544 + C00011 | irev | Forward | c | YALI0B21846g | 1.13.11.27 | 4-hydroxyphenylpyruvate dioxygenase |  | Tyrosine metabolism | Iron |  |  |  | Formerly EC 1.14.2.2 and EC 1.99.1.14 | IK-IKReaction | 1-1-n
R0834 | R03300 | 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase | 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase | 3,4-Dihydroxyphenylacetaldehyde + NAD+ + H2O <=> 3,4-Dihydroxyphenylacetate + NADH + H+ | C04043 + C00003 + C00001 <=> C01161 + C00004 + C00080 | r |  | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Tyrosine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0835 | R03302 | 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase | 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase | 3,4-Dihydroxyphenylacetaldehyde + NADP+ + H2O <=> 3,4-Dihydroxyphenylacetate + NADPH + H+ | C04043 + C00006 + C00001 <=> C01161 + C00005 + C00080 | r |  | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Tyrosine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0836 | R03304 | S-Adenosyl-L-methionine:catechol O-methyltransferase | S-Adenosyl-L-methionine:catechol O-methyltransferase | S-Adenosyl-L-methionine + 3,4-Dihydroxyphenylacetate <=> S-Adenosyl-L-homocysteine + Homovanillate | C00019 + C01161 <=> C00021 + C05582 | irev | Forward | c | YALI0B03124g | 2.1.1.6 | hypothetical protein |  | Tyrosine metabolism |  |  |  |  | The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols. | IKU-IKReaction | 1-1-n
R0837 | R04300 | 4-(2-Aminoethyl)-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing) | 4-(2-Aminoethyl)-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing) | Dopamine + H2O + Oxygen <=> 3,4-Dihydroxyphenylacetaldehyde + NH3 + Hydrogen peroxide | C03758 + C00001 + C00007 <=> C04043 + C00014 + C00027 | irev | Forward | c | YALI0C18315g OR YALI0C22792g | 1.4.3.21 |  |  | Tyrosine metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0848 | R00014 | pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating) | pyruvate:thiamin diphosphate acetal dehydetransferase (decarboxylating) | Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2 | C00022 + C00068 <=> C05125 + C00011 | irev | Forward | m | ( YALI0E27005g AND YALI0F20702g ) OR ( YALI0C00253g AND YALI0C09636g ) | 1.2.4.1 OR 2.2.1.6 |  |  | [NAME], leucine and isoleucine biosynthesis |  |  |  |  |  | IKU-IKReaction OR IKU-IKReaction | n-1-n OR n-1-n
R0849 | R01090 | L-Leucine:2-oxoglutarate aminotransferase | L-Leucine:2-oxoglutarate aminotransferase | L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate | C00123 + C00026 <=> C00233 + C00025 | r |  | c | YALI0D01265g | 2.6.1.42 | hypothetical protein | Branched-chain-amino-acid aminotransferase | [NAME], leucine and isoleucine biosynthesis | Pyridoxal phosphate (By similarity). |  | Unreviewed |  | Also acts on L-isoleucine and L-valine.Different from EC 2.6.1.66. | IKU-IKUReaction | 1-1-n
R0850 | R01213 | acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); 3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) | 3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) | [NAME] <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O | C02504 + C00010 <=> C00024 + C00141 + C00001 | irev | Backward | c | YALI0B07447g | 2.3.3.13 | hypothetical protein |  | [NAME], leucine and isoleucine biosynthesis | Potassium. |  |  |  | Formerly EC 4.1.3.12. | IKU-IKReaction | 1-1-1
R0851 | R01214 | L-Valine:2-oxoglutarate aminotransferase | L-Valine:2-oxoglutarate aminotransferase | L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic acid + L-Glutamate | C00183 + C00026 <=> C00141 + C00025 | r |  | c | YALI0D01265g | 2.6.1.42 | hypothetical protein | Branched-chain-amino-acid aminotransferase | [NAME], leucine and isoleucine biosynthesis | Pyridoxal phosphate (By similarity). |  | Unreviewed |  | Also acts on L-isoleucine and L-valine.Different from EC 2.6.1.66. | IKU-IKUReaction | 1-1-n
[NAME] | R02199 | L-Isoleucine:2-oxoglutarate aminotransferase | L-Isoleucine:2-oxoglutarate aminotransferase | L-Isoleucine + 2-Oxoglutarate <=> (S)-3-Methyl-2-oxopentanoic acid + L-Glutamate | C00407 + C00026 <=> C00671 + C00025 | r |  | c | YALI0D01265g | 2.6.1.42 | hypothetical protein | Branched-chain-amino-acid aminotransferase | [NAME], leucine and isoleucine biosynthesis | Pyridoxal phosphate (By similarity). |  | Unreviewed |  | Also acts on L-isoleucine and L-valine.Different from EC 2.6.1.66. | IKU-IKUReaction | 1-1-n
R0853 | R03656 | L-Isoleucine:tRNA(Ile) ligase (AMP-forming) | L-Isoleucine:tRNA(Ile) ligase (AMP-forming) | ATP + L-Isoleucine + tRNA(Ile) <=> AMP + Diphosphate + L-Isoleucyl-tRNA(Ile) | C00002 + C00407 + C01644 <=> C00020 + C00013 + C03127 | irev | Forward | m | YALI0A00264g OR YALI0C10780g | 6.1.1.5 |  |  | [NAME], leucine and isoleucine biosynthesis |  |  |  |  |  | IKU-IKReaction | n-1-1
R0854 | R03657 | L-Leucine:tRNA(Leu) ligase (AMP-forming) | L-Leucine:tRNA(Leu) ligase (AMP-forming) | ATP + L-Leucine + tRNA(Leu) <=> AMP + Diphosphate + L-Leucyl-tRNA | C00002 + C00123 + C01645 <=> C00020 + C00013 + C02047 | irev | Forward | m | YALI0E24607g OR YALI0F02299g | 6.1.1.4 |  |  | [NAME], leucine and isoleucine biosynthesis |  |  |  |  |  | IKU-IKReaction | n-1-1
R0855 | R03665 | L-Valine:tRNAVal ligase (AMP-forming) | L-Valine:tRNAVal ligase (AMP-forming) | ATP + L-Valine + tRNA(Val) <=> AMP + Diphosphate + L-Valyl-tRNA(Val) | C00002 + C00183 + C01653 <=> C00020 + C00013 + C02554 | irev | Forward | m | YALI0F20218g | 6.1.1.9 | hypothetical protein |  | [NAME], leucine and isoleucine biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
[NAME] | R03656 | L-Isoleucine:tRNA(Ile) ligase (AMP-forming) | L-Isoleucine:tRNA(Ile) ligase (AMP-forming) | ATP + L-Isoleucine + tRNA(Ile) <=> AMP + Diphosphate + L-Isoleucyl-tRNA(Ile) | C00002 + C00407 + C01644 <=> C00020 + C00013 + C03127 | irev | Forward | c | YALI0A00264g OR YALI0C10780g | 6.1.1.5 |  |  | [NAME], leucine and isoleucine biosynthesis |  |  |  |  |  | IKU-IKReaction | n-1-1
R0857 | R03657 | L-Leucine:tRNA(Leu) ligase (AMP-forming) | L-Leucine:tRNA(Leu) ligase (AMP-forming) | ATP + L-Leucine + tRNA(Leu) <=> AMP + Diphosphate + L-Leucyl-tRNA | C00002 + C00123 + C01645 <=> C00020 + C00013 + C02047 | irev | Forward | c | YALI0E24607g OR YALI0F02299g | 6.1.1.4 |  |  | [NAME], leucine and isoleucine biosynthesis |  |  |  |  |  | IKU-IKReaction | n-1-1
[NAME] | R03665 | L-Valine:tRNAVal ligase (AMP-forming) | L-Valine:tRNAVal ligase (AMP-forming) | ATP + L-Valine + tRNA(Val) <=> AMP + Diphosphate + L-Valyl-tRNA(Val) | C00002 + C00183 + C01653 <=> C00020 + C00013 + C02554 | irev | Forward | c | YALI0F20218g | 6.1.1.9 | hypothetical protein |  | [NAME], leucine and isoleucine biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
[NAME] | R03968 + R04001 |  |  |  | C02504 <=> C04411 | r |  | c | YALI0B01364g | 4.2.1.33 | 3-isopropylmalate dehydratase, small subunit | 3-isopropylmalate dehydratase | [NAME], leucine and isoleucine biosynthesis |  | Amino-acid biosynthesis L-leucine biosynthesis L- leucine from 3-methyl-2-oxobutanoate: step 2/4. | Unreviewed |  | Forms part of the leucine-biosynthesis pathway.Brings about the interconversion of the two isomers of isopropylmalate. | IKU-IKUReaction | 1-1-n
R0860 | R04441 | (R)-2,3-Dihydroxy-3-methylbutanoate hydro-lyase | (R)-2,3-Dihydroxy-3-methylbutanoate hydro-lyase | (R)-2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O | C04272 <=> C00141 + C00001 | irev | Forward | m | YALI0C23408g | 4.2.1.9 | dihydroxyacid dehydratase |  | [NAME], leucine and isoleucine biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0861 | R04672 | (S)-2-Acetolactate pyruvate-lyase (carboxylating) | (S)-2-Acetolactate pyruvate-lyase (carboxylating) | (S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate | C06010 + C00068 <=> C05125 + C00022 | irev | Forward | m | YALI0C00253g AND YALI0C09636g | 2.2.1.6 | acetolactate synthase, large subunit | Acetolactate synthase | [NAME], leucine and isoleucine biosynthesis | Binds 1 thiamine pyrophosphate per subunit (By similarity). | Amino-acid biosynthesis L-valine biosynthesis L-valine from pyruvate: step 1/4. | Unreviewed |  | The reaction shown is in the pathway of biosynthesis of valine.The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.Formerly EC 4.1.3.18. | IKU-IKReaction | n-1-n
[NAME] | R04673 | (S)-2-Aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating) | (S)-2-Aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating) | 2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate | C00109 + C05125 <=> C06006 + C00068 | irev | Forward | m | YALI0C00253g AND YALI0C09636g | 2.2.1.6 | acetolactate synthase, large subunit | Acetolactate synthase | [NAME], leucine and isoleucine biosynthesis | Binds 1 thiamine pyrophosphate per subunit (By similarity). | Amino-acid biosynthesis L-valine biosynthesis L-valine from pyruvate: step 1/4. | Unreviewed |  | The reaction shown is in the pathway of biosynthesis of valine.The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.Formerly EC 4.1.3.18. | IKU-IKReaction | n-1-n
R0863 |  |  |  |  | C06007 + C00006 <=> C06006 + C00005 + C00080 | r |  | m | YALI0D03135g | 1.1.1.86 | ketol-acid reductoisomerase |  | [NAME], leucine and isoleucine biosynthesis |  |  |  |  | Formerly EC 1.1.1.89. | IKU-IKReaction | 1-1-n
R0864 | R05070 | (R)-2,3-Dihydroxy-3-methylpentanoate hydro-lyase | (R)-2,3-Dihydroxy-3-methylpentanoate hydro-lyase | (R)-2,3-Dihydroxy-3-methylpentanoate <=> (S)-3-Methyl-2-oxopentanoic acid + H2O | C06007 <=> C00671 + C00001 | irev | Forward | m | YALI0C23408g | 4.2.1.9 | dihydroxyacid dehydratase |  | [NAME], leucine and isoleucine biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0865 | R04439 | (R)-2,3-Dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) | (R)-2,3-Dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) | (R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> (S)-2-Acetolactate + NADPH + H+ | C04272 + C00006 <=> C06010 + C00005 + C00080 | r |  | m | YALI0D03135g | 1.1.1.86 | ketol-acid reductoisomerase |  | [NAME], leucine and isoleucine biosynthesis |  |  |  |  | Formerly EC 1.1.1.89. | IKU-IKReaction | 1-1-n
R0866 | R01652 | NO NAME | NO NAME | 4-Methyl-2-oxopentanoate + CO2 <=> (2S)-2-Isopropyl-3-oxosuccinate | C00233 + C00011 <=> C04236 | irev | Backward | c |  |  |  |  | [NAME], leucine and isoleucine biosynthesis |  |  |  |  | spontaneous reaction
R0867 | R05066 | 3-Hydroxy-2-methylpropanoate:NAD+ oxidoreductase | 3-Hydroxy-2-methylpropanoate:NAD+ oxidoreductase | (S)-3-Hydroxyisobutyrate + NAD+ <=> (S)-Methylmalonate semialdehyde + NADH + H+ | C06001 + C00003 <=> C06002 + C00004 + C00080 | r |  | c | YALI0F02607g | 1.1.1.31 | 3-hydroxyisobutyrate dehydrogenase |  | [NAME], leucine and isoleucine degradation |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0868 | R00935 | (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase (CoA-propanoylating) | (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase (CoA-propanoylating) | (S)-Methylmalonate semialdehyde + CoA + NAD+ <=> Propanoyl-CoA + CO2 + NADH + H+ | C06002 + C00010 + C00003 <=> C00100 + C00011 + C00004 + C00080 | irev | Forward | c | YALI0C01859g | 1.2.1.27 | methylmalonate-semialdehyde dehydrogenase [acylating] |  | [NAME], leucine and isoleucine degradation |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0869 | R03869 | (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase | (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase | (S)-Methylmalonate semialdehyde + NAD+ + H2O <=> Methylmalonate + NADH + H+ | C06002 + C00003 + C00001 <=> C02170 + C00004 + C00080 | irev | Forward | c | YALI0B01298g OR YALI0C03025g OR YALI0E00264g OR YALI0F23793g | 1.2.1.3 |  |  | [NAME], leucine and isoleucine degradation |  |  |  |  |  | IKU-IKReaction | n-1-n
[NAME] | R04095 | 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase | 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase | 3-Methylbutanoyl-CoA + FAD <=> 3-Methylcrotonyl-CoA + FADH2 | C02939 + C00016 <=> C03069 + C01352 | irev | Forward | c | YALI0E12573g | 1.3.99.10 | isovaleryl-CoA dehydrogenase |  | [NAME], leucine and isoleucine degradation | FAD. |  |  |  | Forms with another flavoprotein ('electron-transferring flavoprotein') and EC 1.5.5.1 a system reducing ubiquinone and other acceptors.n-pentanoate can act as donor.Not identical with EC 1.3.99.2, EC 1.3.99.3 or EC 1.3.99.12. | IKU-IKReaction | 1-1-1
R0877 | R00927 | acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase; 2-methylacetoacetyl-CoA thiolase | 2-methylacetoacetyl-CoA thiolase | Propanoyl-CoA + Acetyl-CoA <=> CoA + 2-Methylacetoacetyl-CoA | C00100 + C00024 <=> C00010 + C03344 | irev | Backward | c | YALI0E18568g | 2.3.1.16 | YlPOT1 | 3-ketoacyl-CoA thiolase, peroxisomal | [NAME], leucine and isoleucine degradation |  | Lipid metabolism fatty acid metabolism. | Reviewed | Peroxisome. |  | IKU-IKUReaction | 1-1-n
R0878 | R02662 | 2-methylpropanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase | 2-methylpropanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase | 2-Methylpropanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine | C00630 + C15973 <=> C00010 + C15977 | irev | Backward | c | YALI0D23815g | 2.3.1.168 | hypothetical protein |  | [NAME], leucine and isoleucine degradation |  |  |  |  | A multimer (24-mer) of this enzyme forms the core of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex, and binds tightly both EC 1.2.4.4 and EC 1.8.1.4.The lipoyl group of this enzyme is reductively 2-methylpropanoylated by EC 1.2.4.4, and the only observed direction catalyzed by EC 2.3.1.168 is that where this 2-methylpropanoyl is passed to coenzyme A.In addition to the 2-methylpropanoyl group, formed when EC 1.2.4.4 acts on the oxoacid that corresponds with valine, this enzyme also transfers the 3-methylbutanoyl and S-2-methylbutanoyl groups, donated to it when EC 1.2.4.4 acts on the oxo acids corresponding with leucine and isoleucine. | IKU-IKReaction | 1-1-n
R0879 | R03174 | (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase | (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase | (S)-2-Methylbutanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine | C15980 + C15973 <=> C00010 + C15979 | irev | Backward | c | YALI0D23815g | 2.3.1.168 | hypothetical protein |  | [NAME], leucine and isoleucine degradation |  |  |  |  | A multimer (24-mer) of this enzyme forms the core of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex, and binds tightly both EC 1.2.4.4 and EC 1.8.1.4.The lipoyl group of this enzyme is reductively 2-methylpropanoylated by EC 1.2.4.4, and the only observed direction catalyzed by EC 2.3.1.168 is that where this 2-methylpropanoyl is passed to coenzyme A.In addition to the 2-methylpropanoyl group, formed when EC 1.2.4.4 acts on the oxoacid that corresponds with valine, this enzyme also transfers the 3-methylbutanoyl and S-2-methylbutanoyl groups, donated to it when EC 1.2.4.4 acts on the oxo acids corresponding with leucine and isoleucine. | IKU-IKReaction | 1-1-n
R0880 | R04097 | 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase | 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase | 3-Methylbutanoyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine | C02939 + C15973 <=> C00010 + C15975 | irev | Backward | c | YALI0D23815g | 2.3.1.168 | hypothetical protein |  | [NAME], leucine and isoleucine degradation |  |  |  |  | A multimer (24-mer) of this enzyme forms the core of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex, and binds tightly both EC 1.2.4.4 and EC 1.8.1.4.The lipoyl group of this enzyme is reductively 2-methylpropanoylated by EC 1.2.4.4, and the only observed direction catalyzed by EC 2.3.1.168 is that where this 2-methylpropanoyl is passed to coenzyme A.In addition to the 2-methylpropanoyl group, formed when EC 1.2.4.4 acts on the oxoacid that corresponds with valine, this enzyme also transfers the 3-methylbutanoyl and S-2-methylbutanoyl groups, donated to it when EC 1.2.4.4 acts on the oxo acids corresponding with leucine and isoleucine. | IKU-IKReaction | 1-1-n
R0883 | R04204 | (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA hydro-liase | (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA hydro-liase | (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O | C04405 <=> C03345 + C00001 | irev | Backward | c | YALI0B10406g | 4.2.1.17 | short chain enoyl-CoA hydratase |  | [NAME], leucine and isoleucine degradation |  |  |  |  | Acts in the reverse direction.With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74). | IKU-IKReaction | 1-1-n
R0884 | R04224 | (S)-3-Hydroxyisobutyryl-CoA hydro-lyase | (S)-3-Hydroxyisobutyryl-CoA hydro-lyase | 2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA | C03460 + C00001 <=> C06000 | irev | Forward | c | YALI0B10406g | 4.2.1.17 | short chain enoyl-CoA hydratase |  | [NAME], leucine and isoleucine degradation |  |  |  |  | Acts in the reverse direction.With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74). | IKU-IKReaction | 1-1-n
R0885 | [NAME] | 3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) | 3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) | ATP + 3-Methylcrotonyl-CoA + HCO3- <=> ADP + Orthophosphate + 3-Methylglutaconyl-CoA | C00002 + C03069 + C00288 <=> C00008 + C00009 + C03231 | irev | Forward | c | YALI0B14619g | 6.4.1.4 | 3-methylcrotonoyl-CoA carboxylase, alpha subunit |  | [NAME], leucine and isoleucine degradation | Biotin. |  |  |  |  | IKU-IKReaction | 1-1-1
R0887 | R01954 | L-Citrulline:L-aspartate ligase (AMP-forming) | L-Citrulline:L-aspartate ligase (AMP-forming) | ATP + L-Citrulline + L-Aspartate <=> AMP + Diphosphate + N-(L-Arginino)succinate | C00002 + C00327 + C00049 <=> C00020 + C00013 + C03406 | r |  | c | [NAME] | 6.3.4.5 |  |  | Arginine and proline metabolism
R0888 | R01914 | Spermidine:(acceptor) oxidoreductase | Spermidine:(acceptor) oxidoreductase | [NAME] H2O <=> 1,3-Diaminopropane + 4-Aminobutyraldehyde + Hydrogen peroxide | C00315 + C00007 + C00001 <=> C00986 + C00555 + C00027 | irev | Forward | c | YALI0B00726g | 1.5.99.6 |  |  | beta-Alanine metabolism
R0889 | R00714 | Succinate-semialdehyde:NADP+ oxidoreductase | Succinate-semialdehyde:NADP+ oxidoreductase | Succinate semialdehyde + NADP+ + H2O <=> Succinate + NADPH + H+ | [NAME] C00001 <=> C00042 + C00005 + C00080 | irev | Forward | c | YALI0F26191g | 1.2.1.16 |  |  | Butanoate metabolism | 588 | e-168
R0890 | R00424 | GTP 7,8-8,9-dihydrolase | GTP 7,8-8,9-dihydrolase | GTP + H2O <=> 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate + Formate | C00044 + C00001 <=> C04895 + C00058 | irev | Forward | c | YALI0A10310g | 3.5.4.16 | GTP cyclohydrolase I |  | Folate biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0891 | R05553 | 4-amino-4-deoxychorismate pyruvate-lyase | 4-amino-4-deoxychorismate pyruvate-lyase | 4-Amino-4-deoxychorismate <=> 4-Aminobenzoate + Pyruvate | C11355 <=> C00568 + C00022 | irev | Forward | c |  | 4.1.3.38 |  |  | Folate biosynthesis
R0892 | R00899 | L-cysteinylglycine dipeptidase | L-cysteinylglycine dipeptidase | [NAME] H2O <=> L-Cysteine + Glycine | C01419 + C00001 <=> C00097 + C00037 | r |  | c | YALI0F17842g | DUG1 |  |  | Glutathione metabolism
R0893 |  | methylene-fatty-acyl-phospholipid synthase, yeast-specific | methylene-fatty-acyl-phospholipid synthase, yeast-specific | amet + (0.01) ptdmeeta_SC --> ahcys + h + (0.01) ptd2meeta_SC |  | irev | Forward | c | YALI0E12441g | 2.1.1.16 |  |  | Glycerophospholipid metabolism
R0894 |  | Phosphatidyl-N-methylethanolamine N-methyltransferase, yeast-specific | Phosphatidyl-N-methylethanolamine N-methyltransferase, yeast-specific | amet + (0.01) ptd2meeta_SC --> ahcys + h + (0.01) pc_SC |  | irev | Forward | c | YALI0E12442g | 2.1.1.16 |  |  | Glycerophospholipid metabolism
R0895 |  | [NAME] | [NAME] | h2o + (0.005) pc_SC --> (0.02) dca + (0.06) [NAME] (0.5) g3pc + h + (0.27) [NAME] (0.17) hdcea + (0.05) ocdca + (0.24) ocdcea + (0.09) [NAME]0.1) ttdca |  | irev | Forward | c | ( YALI0F10010g AND [NAME]g ) OR ( YALI0F10010g AND YALI0E16060g ) | 3.1.1.4 AND 3.1.1.4 |  |  | Glycerophospholipid metabolism
R0896 | R06982 | S-(hydroxymethyl)glutathione synthase | S-(hydroxymethyl)glutathione synthase | Glutathione + Formaldehyde <=> S-(Hydroxymethyl)glutathione | C00051 + C00067 <=> C14180 | r |  | c |  |  |  |  | Methane metabolism
R0897 | R03444 | 2-Hydroxybutane-1,2,4-tricarboxylate hydro-lyase | 2-Hydroxybutane-1,2,4-tricarboxylate hydro-lyase | (R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O | C01251 <=> C04002 + C00001 | r |  | m |  |  |  |  | Lysine biosynthesis
R0898 | R05001 | NO NAME | NO NAME | 2-Hydroxyphenylacetate <=> 2,6-Dihydroxyphenylacetate | C05852 <=> C06207 | r |  | c |  |  |  |  | Phenylalanine metabolism
R0899 | R02556 | [NAME] aminohydrolase | [NAME] aminohydrolase | [NAME] + H2O <=> Deoxyinosine + NH3 | C00559 + C00001 <=> C05512 + C00014 | r |  | c |  |  |  |  | Purine metabolism
R0900 | R03531 | 2'-Deoxyinosine-5'-triphosphate pyrophosphohydrolase | 2'-Deoxyinosine-5'-triphosphate pyrophosphohydrolase | dITP + H2O <=> 2'-Deoxyinosine 5'-phosphate + Diphosphate | C01345 + C00001 <=> C06196 + C00013 | irev | Forward | c | YALI0B22924g | 3.6.1.19 |  |  | Purine metabolism
R0901 | R06604 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | 5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate <=> (S)(+)-Allantoin + CO2 | C12248 <=> C02350 + C00011 | irev | Forward | c |  |  |  |  | Purine metabolism
R0902 | R00102 | NAD+ glycohydrolase | NAD+ glycohydrolase | NAD+ + H2O <=> Nicotinamide + ADP-ribose | C00003 + C00001 <=> C00153 + C00301 | irev | Forward | c |  |  |  |  | Purine metabolism
R0903 | R03509 | N-(5-Phospho-beta-D-ribosyl)anthranilate ketol-isomerase | N-(5-Phospho-beta-D-ribosyl)anthranilate ketol-isomerase | N-(5-Phospho-D-ribosyl)anthranilate <=> 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate | C04302 <=> C01302 | r |  | c |  |  |  |  | Phenylalanine, tyrosine and tryptophan biosynthesis
R0904 | R02296 | Cytidine:orthophosphate alpha-D-ribosyltransferase | Cytidine:orthophosphate alpha-D-ribosyltransferase | Cytidine + Orthophosphate <=> Cytosine + alpha-D-Ribose 1-phosphate | C00475 + C00009 <=> C00380 + C00620 | r |  | c |  |  |  |  | Pyrimidine metabolism
R0905 | R01876 | Uridine:phosphate alpha-D-ribosyltransferase | Uridine:phosphate alpha-D-ribosyltransferase | Uridine + Orthophosphate <=> Uracil + alpha-D-Ribose 1-phosphate | C00299 + C00009 <=> C00106 + C00620 | r |  | c |  |  |  |  | Pyrimidine metabolism
R0906 | R07280 | NO NAME | NO NAME | 5-Amino-6-(5'-phospho-D-ribitylamino)uracil + H2O <=> 5-Amino-6-(1-D-ribitylamino)uracil + Orthophosphate | C04454 + C00001 <=> C04732 + C00009 | irev | Forward | c |  |  |  |  | [NAME] metabolism
R0907 | R00188 | Adenosine 3',5'-bisphosphate 3'-phosphohydrolase | Adenosine 3',5'-bisphosphate 3'-phosphohydrolase | Adenosine 3',5'-bisphosphate + H2O <=> AMP + Orthophosphate | C00054 + C00001 <=> C00020 + C00009 | irev | Forward | c | YALI0F27665g | 3.1.3.7 | hypothetical protein |  | Sulfur metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0908 | [NAME] | 3-sn-phosphatidate phosphohydrolase | 3-sn-phosphatidate phosphohydrolase | Sphinganine 1-phosphate + H2O <=> Sphinganine + Orthophosphate | C01120 + C00001 <=> C00836 + C00009 | irev | Forward | c | YALI0E21197g | 3.1.3.4 |  |  | Sphingolipid metabolism
[NAME] | R01825 | D-erythrose 4-phosphate:NAD+ oxidoreductase | D-erythrose 4-phosphate:NAD+ oxidoreductase | D-Erythrose 4-phosphate + NAD+ + H2O <=> 4-Phospho-D-erythronate + NADH + H+ | C00279 + C00003 + C00001 <=> C03393 + C00004 + C00080 | r |  | c |  |  |  |  | [NAME] metabolism
R0911 | R04210 | 4-phospho-D-erythronate:NAD+ 2-oxidoreductase | 4-phospho-D-erythronate:NAD+ 2-oxidoreductase | 4-Phospho-D-erythronate + NAD+ <=> 2-Oxo-3-hydroxy-4-phosphobutanoate + NADH + H+ | C03393 + C00003 <=> C06054 + C00004 + C00080 | r |  | c |  |  |  |  | [NAME] metabolism
R0912 | R03472 | NO NAME | NO NAME | 4-Amino-5-hydroxymethyl-2-methylpyrimidine <=> Aminoimidazole ribotide | C01279 <=> C03373 | irev | Backward | c |  |  |  |  | Thiamine metabolism
R0913 | R02721 | NO NAME | NO NAME | D-Glyceraldehyde 3-phosphate + Pyruvate <=> 5-(2-Hydroxyethyl)-4-methylthiazole | C00118 + C00022 <=> C04294 | irev | Forward | c |  |  |  |  | Thiamine metabolism
R0914 | R02133 | [NAME] hydrolase | [NAME] hydrolase | Thiamine + H2O <=> 4-Amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-Hydroxyethyl)-4-methylthiazole + H+ | C00378 + C00001 <=> C01279 + C04294 + C00080 | irev | Forward | c |  |  |  |  | Thiamine metabolism
R0915 | R00617 | ATP:thiamin-phosphate phosphotransferase | ATP:thiamin-phosphate phosphotransferase | ATP + Thiamin monophosphate <=> ADP + Thiamin diphosphate | C00002 + C01081 <=> C00008 + C00068 | irev | Forward | c |  |  |  |  | Thiamine metabolism
R0916 | R01974 | 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming] | 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming] | Indolepyruvate <=> Indole-3-acetaldehyde + CO2 | C00331 <=> C00637 + C00011 | irev | Forward | c |  |  |  |  | Tryptophan metabolism
R0917 | R03889 | 2-Aminomuconate semialdehyde:NAD+ 6-oxidoreductase | 2-Aminomuconate semialdehyde:NAD+ 6-oxidoreductase | 2-Aminomuconate semialdehyde + NAD+ + H2O <=> 2-Aminomuconate + H+ + NADH | C03824 + C00003 + C00001 <=> C02220 + C00080 + C00004 | irev | Forward | c |  |  |  |  | Tryptophan metabolism
R0918 | R04323 | 2-Amino-3-carboxymuconate semialdehyde carboxy-lyase | 2-Amino-3-carboxymuconate semialdehyde carboxy-lyase | 2-Amino-3-carboxymuconate semialdehyde <=> 2-Aminomuconate semialdehyde + CO2 | C04409 <=> C03824 + C00011 | irev | Forward | c |  |  |  |  | Tryptophan metabolism
R0919 | R01937 | NO NAME | NO NAME | 2-Oxoadipate + NH3 + NAD+ <=> 2-Aminomuconate + NADH + H+ + H2O | C00322 + C00014 + C00003 <=> C02220 + C00004 + C00080 + C00001 | irev | Backward | c |  |  |  |  | Tryptophan metabolism
R0920 | [NAME] | NO NAME | NO NAME | Indole-3-acetate + Oxygen <=> 3-Methyldioxyindole + CO2 | C00954 + C00007 <=> C05834 + C00011 | irev | Forward | c |  |  |  |  | Tryptophan metabolism |  |  |  |  | spontaneous reaction
R0921 | R02519 | Homogentisate:oxygen 1,2-oxidoreductase (decyclizing) | Homogentisate:oxygen 1,2-oxidoreductase (decyclizing) | Homogentisate + Oxygen <=> 4-Maleylacetoacetate | C00544 + C00007 <=> C01036 | irev | Forward | c |  |  |  |  | Tyrosine metabolism
R0922 | R03181 | 4-Maleylacetoacetate cis-trans-isomerase | 4-Maleylacetoacetate cis-trans-isomerase | 4-Maleylacetoacetate <=> 4-Fumarylacetoacetate | C01036 <=> C01061 | irev | Forward | c |  |  |  |  | Tyrosine metabolism
R0923 | R01364 | 4-fumarylacetoacetate fumarylhydrolase | 4-fumarylacetoacetate fumarylhydrolase | Acetoacetate + Fumarate <=> 4-Fumarylacetoacetate + H2O | C00164 + C00122 <=> C01061 + C00001 | irev | Backward | c |  |  |  |  | Tyrosine metabolism
R0924 | R04426 | 3-Isopropylmalate:NAD+ oxidoreductase | 3-Isopropylmalate:NAD+ oxidoreductase | (2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+ | C04411 + C00003 <=> C04236 + C00004 + C00080 | r |  | c |  |  |  |  | [NAME], leucine and isoleucine biosynthesis
R0925 | R02085 | (S)-3-Hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming) | (S)-3-Hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming) | (S)-3-Hydroxy-3-methylglutaryl-CoA <=> 3-Methylglutaconyl-CoA + H2O | C00356 <=> C03231 + C00001 | r |  | c |  |  |  |  | [NAME], leucine and isoleucine degradation
R0926 | R02661 | 2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase | 2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase | 2-Methylpropanoyl-CoA + FAD <=> 2-Methylprop-2-enoyl-CoA + FADH2 | C00630 + C00016 <=> C03460 + C01352 | r |  | c |  |  |  |  | [NAME], leucine and isoleucine degradation
R0927 | R05064 | (S)-3-Hydroxyisobutyryl-CoA hydrolase | (S)-3-Hydroxyisobutyryl-CoA hydrolase | (S)-3-Hydroxyisobutyryl-CoA + H2O <=> CoA + (S)-3-Hydroxyisobutyrate | C06000 + C00001 <=> C00010 + C06001 | irev | Forward | c |  |  |  |  | [NAME], leucine and isoleucine degradation
R0928 | [NAME] | (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase | (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase | (S)-2-Methylbutanoyl-CoA + FAD <=> 2-Methylbut-2-enoyl-CoA + FADH2 | C15980 + C00016 <=> C03345 + C01352 | r |  | c |  |  |  |  | [NAME], leucine and isoleucine degradation
[NAME] | R04203 | (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase | (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase | (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ <=> 2-Methylacetoacetyl-CoA + NADH + H+ | C04405 + C00003 <=> C03344 + C00004 + C00080 | r |  | c |  |  |  |  | [NAME], leucine and isoleucine degradation
R0930 | R00833 | (R)-Methylmalonyl-CoA CoA-carbonylmutase | (R)-Methylmalonyl-CoA CoA-carbonylmutase | (R)-Methylmalonyl-CoA <=> Succinyl-CoA | C01213 <=> C00091 | irev | Forward | c |  |  |  |  | [NAME], leucine and isoleucine degradation
R0931 | R03383 | NO NAME | NO NAME | (R)-Methylmalonyl-CoA + H2O <=> Methylmalonate + CoA | C01213 + C00001 <=> C02170 + C00010 | irev | Backward | c |  |  |  |  | [NAME], leucine and isoleucine degradation
R0932 | R08375 | NO NAME | NO NAME | [NAME] diphosphate <=> Dolichyl diphosphate | C05859 <=> C00621 | irev | Forward | c |  |  |  |  | Terpenoid backbone biosynthesis
R0933 | R01004 | Dolichyl-diphosphate phosphohydrolase | Dolichyl-diphosphate phosphohydrolase | Dolichyl diphosphate + H2O <=> Dolichyl phosphate + Orthophosphate | [NAME] + C00001 <=> C00110 + C00009 | irev | Forward | c | YALI0D21032g | 3.6.1.43 | hypothetical protein |  | N-Glycan biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0934 | R01018 | CTP:dolichol O-phosphotransferase | CTP:dolichol O-phosphotransferase | CTP + Dolichol <=> CDP + Dolichyl phosphate | C00063 + C00381 <=> C00112 + C00110 | irev | Forward | c | YALI0E18942g | 2.7.1.108 | [NAME] |  | N-Glycan biosynthesis |  |  |  |  |  | IKU-IKReaction | 1-1-1
R0935 | R01009 | GDPmannose:dolichyl-phosphate O-beta-D-mannosyltransferase | GDPmannose:dolichyl-phosphate O-beta-D-mannosyltransferase | GDP-mannose + Dolichyl phosphate <=> GDP + Dolichyl phosphate D-mannose | C00096 + C00110 <=> C00035 + C03862 | irev | Forward | c | YALI0D06281g AND YALI0B05500g AND YALI0A18656g | 2.4.1.83 |  |  | N-Glycan biosynthesis |  |  |  |  | Acts only on long-chain polyprenyl phosphates and alpha- [NAME], larger than C(35). | IKU-IKReaction | n-1-1
R0936 |  | Dolichyl-phosphate-mannose--protein mannosyltransferase, | Dolichyl-phosphate-mannose--protein mannosyltransferase, | Dolichyl phosphate D-mannose <=> Dolichyl phosphate + H + mannan | C03862 <=> C00110 + C00080 + C00464 | irev | Forward | c | YALI0C23364g OR YALI0E05929g OR YALI0E15081g | 2.4.1.109 |  |  | N-Glycan biosynthesis
R0937 | R01702 | 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) | 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) | 4-Methyl-2-oxopentanoate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine + CO2 | C00233 + C15972 <=> C15975 + C00011 | irev | Forward | c | [NAME] AND YALI0F05038g | 1.2.4.4 |  |  | [NAME], leucine and isoleucine degradation | Thiamine diphosphate. |  |  |  | It acts not only on 3-methyl-2-oxobutanaoate, but also on 4-methyl-2- oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine.It is a component of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.168, which also binds multiple copies of EC 1.8.1.4.It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.168.Formerly EC 1.2.4.3. | IKU-IKReaction | n-1-n
R0938 | R01701 | 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) | 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) | 3-Methyl-2-oxobutanoic acid + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 | C00141 + C15972 <=> C15977 + C00011 | irev | Forward | c | [NAME] AND YALI0F05038g | 1.2.4.4 |  |  | [NAME], leucine and isoleucine degradation | Thiamine diphosphate. |  |  |  | It acts not only on 3-methyl-2-oxobutanaoate, but also on 4-methyl-2- oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine.It is a component of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.168, which also binds multiple copies of EC 1.8.1.4.It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.168.Formerly EC 1.2.4.3. | IKU-IKReaction | n-1-n
[NAME] | R04225 | (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) | (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) | (S)-3-Methyl-2-oxopentanoic acid + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2 | C00671 + C15972 <=> C15979 + C00011 | irev | Forward | c | [NAME] AND YALI0F05038g | 1.2.4.4 |  |  | [NAME], leucine and isoleucine degradation | Thiamine diphosphate. |  |  |  | It acts not only on 3-methyl-2-oxobutanaoate, but also on 4-methyl-2- oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine.It is a component of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.168, which also binds multiple copies of EC 1.8.1.4.It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.168.Formerly EC 1.2.4.3. | IKU-IKReaction | n-1-n
R0940 | R05616 | NO NAME | NO NAME | all-trans-Hexaprenyl diphosphate + 4-Hydroxybenzoate <=> 3-Hexaprenyl-4-hydroxybenzoate + Diphosphate | C01230 + C00156 <=> C13425 + C00013 | irev | Forward | m | YALI0F05610g | 2.5.1.39 |  |  | Ubiquinone and other terpenoid-quinone biosynthesis
R0941 | [NAME] | NO NAME | NO NAME | 3-Hexaprenyl-4-hydroxybenzoate + Oxygen <=> 3-Hexaprenyl-4,5-dihydroxybenzoate | C13425 + C00007 <=> C05200 | irev | Forward | c |  |  |  |  | Ubiquinone and other terpenoid-quinone biosynthesis |  |  |  |  | spontaneous reaction
R0942 | R04711 | S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase | S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase | S-Adenosyl-L-methionine + 3-Hexaprenyl-4,5-dihydroxybenzoate <=> S-Adenosyl-L-homocysteine + 3-Hexaprenyl-4-hydroxy-5-methoxybenzoate + H+ | C00019 + C05200 <=> C00021 + C05313 + C00080 | irev | Forward | m | YALI0B15884g | 2.1.1.114 | 3-demethylubiquinone-9 3-methyltransferase |  | Ubiquinone and other terpenoid-quinone biosynthesis |  |  | Unreviewed |  | This enzyme is involved in ubiquinone biosynthesis.Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units.However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast.The enzymes from yeast and rat also catalyze the methylation of 3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively (this activity is classified as EC 2.1.1.64). | IKU-differenceReaction | 1-1-n
R0943 | R06866 | NO NAME | NO NAME | 3-Hexaprenyl-4-hydroxy-5-methoxybenzoate <=> 2-Hexaprenyl-6-methoxyphenol + CO2 | C05313 <=> C05802 + C00011 | irev | Forward | m |  |  |  |  | Ubiquinone and other terpenoid-quinone biosynthesis |  |  |  |  | spontaneous reaction
R0944 | R04982 | NO NAME | NO NAME | 2-Hexaprenyl-6-methoxyphenol + Oxygen <=> 2-Hexaprenyl-6-methoxy-1,4-benzoquinone + H2O | C05802 + C00007 <=> C05803 + C00001 | irev | Forward | m | YALI0A09042g |  |  |  | Ubiquinone and other terpenoid-quinone biosynthesis
R0945 | R04983 | NO NAME | NO NAME | 2-Hexaprenyl-6-methoxy-1,4-benzoquinone + S-Adenosyl-L-methionine <=> 2-Hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-Adenosyl-L-homocysteine | C05803 + C00019 <=> C05804 + C00021 | irev | Forward | m | YALI0C18205g |  |  |  | Ubiquinone and other terpenoid-quinone biosynthesis
R0946 | R04984 | NO NAME | NO NAME | 2-Hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + Oxygen + NADPH + H+ <=> 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + NADP+ + H2O | C05804 + C00007 + C00005 + C00080 <=> C05805 + C00006 + C00001 | irev | Forward | m | YALI0E15224g |  |  |  | Ubiquinone and other terpenoid-quinone biosynthesis
[NAME] | R02175 | S-adenosyl-L-methionine:2-hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase | S-adenosyl-L-methionine:2-hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase | 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosyl-L-methionine <=> Ubiquinone-6 + S-Adenosyl-L-homocysteine | C05805 + C00019 <=> C17568 + C00021 | irev | Forward | m | YALI0B15884g | 2.1.1.114 | 3-demethylubiquinone-9 3-methyltransferase |  | Ubiquinone and other terpenoid-quinone biosynthesis |  |  | Unreviewed |  | This enzyme is involved in ubiquinone biosynthesis.Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units.However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast.The enzymes from yeast and rat also catalyze the methylation of 3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively (this activity is classified as EC 2.1.1.64). | IKU-differenceReaction | 1-1-n
R0948 | [NAME] | acetyl-CoA:L-serine O-acetyltransferase | acetyl-CoA:L-serine O-acetyltransferase | L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA | C00065 + C00024 <=> C00979 + C00010 | r |  | c |  |  |  |  | Cysteine and methionine metabolism