question stringlengths 142 349 | expert_answer stringlengths 251 378 | topic stringclasses 2
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A 29-year-old planning IVF in 3 months asks whether receiving an mRNA COVID-19 vaccine will reduce her egg quality or implantation success. What does the current evidence show, and what should she be told? | Receiving an mRNA COVID-19 vaccine will not affect egg quality or implantation success in IVF, regardless of timing. Studies have shown no impact on fresh IVF outcomes compared with pre-treatment vaccinated or unvaccinated patients. Overall, COVID-19 vaccination in women undergoing ART appears safe, especially with mRN... | Fertility |
A 30-year-old with a BMI of 19 stopped combined oral contraceptives 5 months ago and has not had a period. What is the first step in evaluation, what is the most likely explanation given her BMI, and at what point does post-pill amenorrhea warrant further investigation? | The first step is to rule out pregnancy. Given a BMI of 19, the most likely explanation is functional hypothalamic amenorrhea related to low energy balance, stress, or weight changes. Post-pill amenorrhea should generally be evaluated if it persists beyond about 3 months, with workup including pregnancy test, TSH, prol... | Fertility |
A 36-year-old Black woman with a BMI of 32 and an AMH of 0.4 ng/mL asks how many egg freezing cycles she will need to have at least a 70% cumulative live birth probability. What does evidence suggest about expected mature egg yield per cycle at her age and reserve level, and how might her BMI affect stimulation respons... | She may need about 2–3 cycles of egg pooling to approach a 70% cumulative live birth probability, with a target of roughly 10–12 eggs total. At an AMH of 0.4 ng/mL and age 36, expected mature egg yield is likely low, around 3–4 eggs per cycle. Her BMI may increase gonadotropin requirements and should be factored into s... | Fertility |
A patient undergoing IVF develops a fever of 38.5°C on day 3 post egg retrieval. She asks whether this will affect her embryos. What is the primary clinical concern here, and what is the most important next step? | Fever after egg retrieval is not expected and raises concern for a serious infection such as pelvic infection or abscess, or for severe OHSS with complications. The most important next step is urgent same-day evaluation with the fertility team or emergency care, including exam, labs, pelvic ultrasound, and prompt treat... | Fertility |
Black women are disproportionately affected by uterine fibroids compared to white women. What is the approximate difference in prevalence, at what age do symptoms typically present in each group, and what factors are thought to explain this disparity? | Black women tend to develop fibroids and fibroid symptoms about 10 years earlier than other groups. The disparity is thought to be multifactorial, including genetic susceptibility, hormonal influences, higher rates of obesity, and broader inequities in access to care and timely treatment. | Fertility |
What is the relative risk of stillbirth for a woman with a BMI over 35 compared to a woman with a BMI of 20–25, and what other significant pregnancy complications are elevated at this BMI — including chromosomal abnormalities and pre-eclampsia? What additional monitoring is recommended in the third trimester? | The risk of stillbirth in a woman with a BMI over 35 is about twice that of a woman with a BMI of 20–25. Other elevated risks include miscarriage, pre-eclampsia, and gestational diabetes. Third-trimester monitoring should include serial growth scans and close monitoring of blood pressure and blood sugar, ideally under ... | Fertility |
Does placing a laptop on the lap reduce female fertility? What is the evidence, and who does the thermal fertility concern primarily apply to? | There is no good evidence that typical laptop-on-lap use reduces female fertility, because the ovaries are internal and not exposed to comparable heat. The thermal fertility concern primarily applies to male fertility, since increased scrotal temperature can affect spermatogenesis and sperm quality. | Fertility |
A 34-year-old with one blocked fallopian tube and normal ovarian reserve asks whether she can still conceive naturally and whether she needs IVF immediately. What is the appropriate recommendation, and what specific obstetric risk must she be counseled about if she pursues natural conception? | She can still conceive naturally if the other tube is patent and ovulation and semen parameters are otherwise normal, so IVF is not automatically required right away. Management depends on age, duration of infertility, and the rest of the evaluation. If she tries naturally, she should be counseled about the increased r... | Fertility |
What is the recommended first-line fertility treatment for a woman with bilateral tubal factor infertility — IVF or tubal surgery — and what factors most influence this choice? | IVF is generally the recommended first-line treatment for bilateral tubal factor infertility. The choice is influenced by age, severity and cause of tubal disease, whether hydrosalpinx is present, other comorbid conditions, and semen analysis results. | Fertility |
A 38-year-old has 4 blastocysts after IVF. What is the approximate live birth rate per blastocyst transfer at her age, and how does this differ from a 32-year-old? She is considering preimplantation genetic testing (PGT-A) and asks whether the trophectoderm biopsy required will reduce the viability of her embryos — wha... | Live birth rate per blastocyst transfer at age 38 is about 25–30%, compared with around 50% for a 32-year-old. Current evidence suggests trophectoderm biopsy is very unlikely to reduce embryo viability when performed by experienced labs, and PGT-A may help reduce miscarriage risk by identifying euploid embryos. | Fertility |
What is the difference in venous thromboembolism (VTE) risk between oral estrogen and transdermal estrogen in HRT, and which route is recommended for women with cardiovascular risk factors or a history of VTE? | Oral estrogen is associated with a higher risk of venous thromboembolism, whereas transdermal estrogen shows little to no increased VTE risk. For women with cardiovascular risk factors or a history of VTE, transdermal estrogen is the preferred route. If the uterus is present, progestogen is still needed. | Hormonal Health / HRT |
A 52-year-old has been on combined HRT (estrogen + progestogen) for 9 years and asks whether she should stop. What does current guidance say about duration of HRT use, and what is the primary risk being managed with long-term combined use? | There is no fixed maximum duration for combined HRT. Treatment can continue as long as the benefits outweigh the risks for the individual, with at least annual review and shared decision-making. The main long-term risk managed with combined estrogen–progestogen therapy is increased breast cancer risk. | Hormonal Health / HRT |
Womens Health Benchmark Ground Truth
A curated evaluation dataset for assessing large language models (LLMs) in womens health-related tasks. The dataset consists of model stumps paired with expert-written justifications describing observed errors.
Research Focus
This dataset supports structured evaluation of LLM behavior in clinically relevant womens health contexts, with emphasis on safety, reasoning quality, and evidence alignment.
Methodology
The dataset was developed in collaboration with women's health experts across obstetrics and gynecology, reproductive endocrinology, fertility nursing, gynecologic oncology, and clinical women's health research.
The model stumps represent realistic prompts drawn from:
- Patient-facing scenarios
- Clinician decision-making contexts
- Evidence-based medical questions
Each prompt is paired with an expert justification explaining the identified issue.
Public Sharing Scope
This repository contains only a sample subset of the full benchmark dataset that is being publicly shared for transparency and research preview purposes.
Dataset Description
The dataset is designed for benchmarking and analysis workflows where transparent, expert-grounded error attribution is required.
Published Report
- WHBench report: https://therubric.ai/research/whbench
Notes
- Intended for benchmarking and research workflows.
- Not intended for direct clinical decision making.
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