Mpox Vaccination - NYC Health

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Mpox: Vaccination

Get Vaccinated

If you are at risk for mpox, get vaccinated if you have not done so already. It is important to get two doses for maximum protection, so get your second dose if you haven't done so already. There is no recommendation for a booster dose (a third dose) at this time.

The JYNNEOS mpox vaccine is expected to provide protection against both Clade I and Clade II mpox virus.

Contact your sexual health provider to see if they are offering the mpox vaccine. You can also find a vaccination site on the NYC Vaccine Finder.

Mpox Vaccine Finder

Getting vaccinated for mpox can reduce your chance of getting mpox, and it can reduce symptoms if you do get it.

You should get a second dose at least 28 days after your first dose.

It is important to get the second dose regardless of the amount of time that has passed since the first dose. You do not need to restart the two-dose vaccine series if your second dose is delayed.

Who Should Get Vaccinated

Talk to your provider about vaccination if:

You have sex with men and identify as male, trans, nonbinary, genderqueer or gender non-conforming.

You are planning to visit a country where clade I mpox virus is spreading and you anticipate sex with a new partner while traveling, regardless of your sexual orientation or gender identity.

You consider yourself to be at risk for mpox through sex or other intimate contact now or in the future. (Learn more about how mpox spreads.)

If you have recently been in close contact with someone you think has mpox, you should get the vaccine as soon as possible and no later than 14 days after the exposure.

If you’ve already had mpox, you do not need to get vaccinated. You have immunity, so your body can protect itself.

People with certain allergies to vaccine ingredients or chicken or egg protein should talk to a health care provider to confirm if they should get the vaccine. If you do not have a provider, call 311.

JYNNEOS Vaccine for Mpox: Frequently Asked Questions (PDF)

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Side Effects

Common side effects of the JYNNEOS vaccine include tiredness, headache and muscle pain. There may also be redness, swelling, soreness and itchiness where you received the injection.