the-french-artist/wikipedia_20220301.simple_sentence_embeddings huggingface dataset:
Alzheimer's disease 
 In different parts of the of cell including the outermost part of the cell membrane, chemicals called enzymes snip the APP into small pieces.
Alzheimer's disease 
 Depending on which enzyme is doing the snipping and what parts of the APP are snipped, two different things can happen.
Alzheimer's disease 
 The plaques are formed when beta-secretase snips the APP molecule at one end of the beta-amyloid peptide, releasing sAPPβ from the cell.
Alzheimer's disease 
 Gamma-secretase then cuts the pieces of APP that is left and, still sticking out of the neuron’s membrane, at the other end of the beta-amyloid peptide.
Alzheimer's disease 
 After this snipping the beta-amyloid peptide is released into the space outside the neuron and begins to stick to other beta-amyloid peptides.
Alzheimer's disease 
 Different oligomers of various sizes are now floating around in the spaces between the neurons, which may be responsible for reacting with receptors on neighboring cells and synapses, affecting their ability to function.
Alzheimer's disease 
 As more pieces clump togther the oligomers get bigger larger, and the next size up are called protofibrils and the next size after that are called fibrils.
Alzheimer's disease 
 After a while, these fibrils clump together with other protein molecules, neurons and non-nerve cells floating around in the space between the cells and form what are called plaques.
Alzheimer's disease 
 Deposits of beta-amyloid also form in the walls (in the tunica media, the middle layer, and  tunica adventitia or tunica externa, the outer layer) of small and mid-sized arteries (and sometimes veins) in the cerebral cortex and the leptomeninges (the leptomeninges are the two inner layers - pia mater and arachnoid - of the meninges, a protective 3-layer membrane covering the brain.)
Alzheimer's disease 
 CAA is found in 30% of people over the age of 60 years who do not have any dementia but is found in 90%-96% of people with Alzheimer disease and is severe in one third to two thirds of these cases.
Alzheimer's disease 
 The first area of the brain to be affected by Alzheimer's is the "transentorhinal region" which is part of the medial temporal lobe located deep within the brain.
Alzheimer's disease 
 It then spreads into the adjacent entorhinal cortex (EC) which acts as a central hub, for a widespread network that handles signals for memory and movement(like a main train station with train tracks going to different areas).
Alzheimer's disease 
 The EC is the main area for communication between the hippocampus, and the neocortex - which is the outer portion of the brain responsible for higher functioning such as how the brain perceives information from the five senses; (smell, sight, taste, touch and hearing; Ex.
Alzheimer's disease 
 seeing a person's face and recognizing them,) generating motor commands (Ex, moving and arm or leg, walking, running) spatial reasoning, conscious thought and language.
Alzheimer's disease 
 The hippocampus is the part of the brain that is involved in forming new memories, organizing them, and storing them for later recall.
Alzheimer's disease 
 The hippocampus then sends memories to the different parts of the cerebral hemisphere where they are placed in long-term storage and it helps retrieve them when necessary.
Alzheimer's disease 
 In addition to handling memory the hippocampus is also involved in emotional responses, navigation (getting around) and spatial orientation (knowing your sense of place as you move around Example: Knowing your way around your bedroom even with the lights off).
Alzheimer's disease 
 There are actually two parts of the hippocampus which is shaped like a horseshoe with one in the left part of the brain and the other in the right part of the brain.
Alzheimer's disease 
 Naming the colors of the first set of words is easier and quicker than the second, because in the first set, the colors match the words, in the second set they do not.
Alzheimer's disease 
 People having problems with attention as may happen in early-stage Alzheimer's tend to do poorly on this test.
Alzheimer's disease 
 With current research using advances in neuroimaging such as FDG-PET and PIB-PET scans, and cerebrospinal fluid (CSF) assays, it is now possible to detect the beginning processes of Alzheimer's disease that occur before symptoms begin.
Alzheimer's disease 
 The research suggests that clinically normal older people (no symptoms at all) have biomarker evidence of amyloid beta (Aβ) build-up in the brain.
Alzheimer's disease 
 This amyloid beta (Aβ) is linked to changes in the structure of the brain and how it works that is the similar to what is seen in people with mild cognitive impairment (MCI) - which may lead to Alzheimer's - and people with Alzheimer's.
Alzheimer's disease 
 These small preclinical changes (no symptoms) in the brain may occur many years, to even a few decades before a person is diagnosed with Alzheimer's.
Alzheimer's disease 
 These changes put a person at risk of developing the clinical symptoms of full-blown  Alzheimer's but not everyone who has these changes will get the disease.
Alzheimer's disease 
 Even though there is no cure for Alzheimer's, there are new treatments which are being developed which would work better in the very first stages of the disease.
Alzheimer's disease 
 At this time exactly what makes up the preclinical phase of Alzheimer's is still being researched, such as why some people with go on to develop Alzheimer's and others do not.
Alzheimer's disease 
 There is a worldwide effort in various countries doing research in this area known as the World Wide Alzheimer's Disease Neuroimaging Initiative (WW-ADNI) which is the umbrella organization for neuroimaging studies being carried out through the North American ADNI, European ADNI (E-ADNI), Japan ADNI, Australian ADNI (AIBL), Taiwan ADNI, Korea ADNI, China ADNI and Argentina ADNI.
Alzheimer's disease 
 "Misdiagnosis in very early stages of Alzheimer's is a significant problem, as there are more than 100 conditions that can mimic the disease.
Alzheimer's disease 
 In people with mild memory complaints, our accuracy is barely better than chance," according to study researcher P. Murali Doraiswamy, MBBS, professor of psychiatry and medicine at Duke Medicine, "Given that the definitive gold standard for diagnosing Alzheimer's is autopsy, we need a better way to look into the brain."
Alzheimer's disease 
 In 1901, a 51-year-old woman named Auguste Deter, was committed to the City Asylum for the Insane and Epileptic, (Städtischen Anstalt für Irre und Epileptische) in Frankfurt am Main, Germany which had the nickname  "Irrenschloss" (Castle of the Insane).
Alzheimer's disease 
 She was married and had a normal life until eight months prior to her commitment, when she started having psychological and neurological problems, such as problems with memory and language, paranoia, becoming disorientated and having hallucinations.
Alzheimer's disease 
 Alzheimer became interested in her case because of her age; while the effects of senile dementia were known at the time, they usually did not start until a person was in their early to mid-sixties.
Alzheimer's disease 
 Her case was also notable because of the rapid onset of dementia, only eight months, from the first reported symptoms, until she was committed.
Alzheimer's disease 
 While conducting one of his examinations of Ms. Deter, he asked her to perform a series of simple writing tasks.
Alzheimer's disease 
 Unable to do what was asked such as write her name, she said "I have lost myself, so to speak" ("Ich habe mich sozusagen selbst verloren").
Alzheimer's disease 
 Alzheimer left the hospital in Franfkurt in 1902 to begin working with Emil Kraepelin at the Psychiatric University Hospital in Heidelberg-Bergheim, and in 1903 both he and Kraepelin began working at Ludwig Maximilian University in Munich.
Alzheimer's disease 
 When Ms. Deter died of septicemia on 8 April 1906, Alzheimer was informed and her brain was sent to Munich for him to study.
Alzheimer's disease 
 Studying samples of her brain under a microscope he noticed neurofibriallry tangles and bundles made up of beta-amyloid plaque, which are two of the main features of the disease.
Alzheimer's disease 
 On 3 November 1906, Alzheimer presented the results of his findings in Auguste's case at the Conference of South-West German Psychiatrists in Tübingen, and he published his findings in the case in 1907.
Alzheimer's disease 
 Alzheimer's disease usually beigins affecting people between ages 60–65, in Ms. Deter's case - who was 55-years-old when she died - she had a form of what is now known as Early-onset Alzhiemer's disease.
Alzheimer's disease 
 Some of the famous people who have gotten Alzheimer's disease are former United States President Ronald Reagan and Irish writer Iris Murdoch, both of whom were the subjects of scientific articles examining how their cognitive capacities got worse with the disease.
Alzheimer's disease 
 Other cases include the retired footballer Ferenc Puskás, the former Prime Ministers Harold Wilson (United Kingdom) and Adolfo Suárez (Spain), the actress Rita Hayworth, the Nobel Prize-winner Raymond Davis, Jr., the actors Charlton Heston and Gene Wilder, the novelist Terry Pratchett, politician and activist Sargent Shriver, the Blues musician B.B. King, director Jacques Rivette, Indian politician George Fernandes,
Elaine Paige 
 She studied acting at the Aida Foster stage school in London and then played roles in the British tour of the show The Roar of the Greasepaint, the Smell of the Crowd and the first London production of Hair.
Elaine Paige 
 She played Sandy in the London production of Grease and appeared as one of Michael Crawford's girlfriends in Billy.
Elaine Paige 
 She has since said she was about to leave the world of acting, possibly to become a teacher, but then the role in Evita was offered to her.
Elaine Paige 
 When the actress Judi Dench had an injury during rehearsals for Cats, the producers asked Paige play the role in stead of Dench.
Elaine Paige 
 Fortunately, the song was "Memory", which was a top 10 hit for Paige and has become her signature song.
Elaine Paige 
 After Cats, she appeared in Abbacadbra, an ABBA compilation, and Chess, also written by Benny Andersson and Björn Ulvaeus of ABBA but with lyrics by Tim Rice, co-writer of Evita.
Elaine Paige 
 Paige then scored a number 1 single, "I Know Him So Well", a song from Chess, as a duet with Barbara Dickson.
Elaine Paige 
 In 1989, she co-produced and starred in a production of Cole Porter's Anything Goes in London, which made a star of John Barrowman.
Elaine Paige 
 In the early 1990s, her term relationship with the lyricist Tim Rice stopped and Paige tried an image change by recording an album with a California-based producer in the Bette Midler torch singer vein entitled Love Can Do That.
Elaine Paige 
 Her solo albums had so far been a variety of songs, including the very successful Stages in 1983, with songs from musical theatre.
Elaine Paige 
 In 1993, she returned to the United States to work with Peter Matz on an album called Romance and the Stage featuring songs from earlier days of musical theatre.
Elaine Paige 
 The following year, she recorded, Piaf, which had music from the role she was playing in the Pam Gems play, also called Piaf.
Elaine Paige 
 However, in 1995 she had a role in another musical, playing Norma Desmond in Andrew Lloyd Webber's Sunset Boulevard.
Elaine Paige 
 She later had another role in 2000 with the King and I. She has recently moved more into television and radio work.
Marti Webb 
 She has notably played roles in musical theatre including Evita, Cats, Godspell, The King and I, Annie, Thoroughly Modern Millie, The Goodbye Girl and Song and Dance.
Marti Webb 
 She first came to prominence with the song cycle "Tell Me on a Sunday" which was written for her by Don Black and Andrew Lloyd Webber.
Marti Webb 
 Webb recently returned to the show after it was revamped for Denise Van Outen in the West End before she took it on a UK tour.
Yahtzee 
 The object of the game is to roll five dice (up to three times) to create certain combinations such as:
Yahtzee 
 Full house (three dice showing the same number and the remaining two dice showing a different number but both matching)
Tim Rice 
 Rice is probably best known for his work with Andrew Lloyd Webber on the shows Joseph and the Amazing Technicolor Dreamcoat, Jesus Christ Superstar, and Evita.
Evita (musical) 
 The musical is based on the life of Eva Perón (1919-1952), the wife of Argentine President Juan Perón, which Che is telling.
March 8 
 1576 – Spanish explorer Diego Garcia de Palacio sights the ruins of the ancient Mayan city of Copan.
March 8 
 1618 – Johannes Kepler discovers the third law of planetary motion (he soon rejects the idea after some initial calculations were made but later on May 15 confirms the discovery).
March 8 
 1702 – Very unexpectedly, Anne Stuart, the sister of the childless Mary II, becomes Queen of England, Scotland and Ireland after the death of William III of Orange from injuries he suffered in a fall from his horse.
March 8 
 1775 - An anonymous letter, thought by some to have been written by Thomas Paine, calls for the end of slavery in the North American colonies.
March 8 
 1782 – Gnadenhütten massacre: Almost 100 Native Americans in Gnadenhutten, Ohio had their skulls crushed with a mallet by Pennsylvanian militiamen in a mass murder.
March 8 
 1862 – American Civil War: The iron-clad CSS Virginia (formerly USS Merrimack) is launched at Hampton Roads, Virginia.
March 8 
 1884 – Susan B. Anthony testified before the Judiciary Committee of the House of Representatives arguing for an amendment to the U.S. Constitution granting women the right to vote.
March 8 
 1906 – Moro Crater Massacre: US troops occupying the Philippines massacre about 600 men, women and children taking refuge in a crater.
March 8 
 1921 – Spanish Premier Eduardo Dato is assassinated while exiting the parliament building in Madrid.
March 8 
 1943 – World War II: Japanese troops counter-attack American forces on Hill 700 in Bougainville in a battle that will last five days.
March 8 
 1948 – The United States Supreme Court rules that religious instruction in public schools violated the Constitution.
March 8 
 1961 – Max Conrad circumnavigates the earth in eight days, 18 hours and 49 minutes setting a new world record.
March 8 
 1965 – Vietnam War: 3,500 United States Marines arrive in South Vietnam, becoming the first American combat troops in Vietnam.
March 8 
 1966 – Vietnam War: Australia announces it is going to substantially increase its number of troops in Vietnam.
March 8 
 1978 – The first ever radio episode of The Hitchhiker's Guide to the Galaxy, by Douglas Adams is transmitted on BBC Radio 4.
March 8 
 1999 – Oklahoma City bombing: The Supreme Court of the United States upholds the murder convictions of Timothy McVeigh.
March 8 
 2003 - A referendum on EU membership is held in Malta, with a narrow majority supporting the proposal.
March 8 
 2014 - Malaysia Airlines Flight 370, travelling from Kuala Lumpur to Beijing, goes missing in the Gulf of Thailand with 239 people on board.
March 8 
 2017 - The famous "Azure Window" feature on the coast of the Maltese island of Gozo collapses into the sea.
March 8 
 2017 - FC Barcelona come back from a 4-0 deficit from the first leg of their UEFA Champions League tie against Paris Saint-Germain F.C. to win 6-1 on the night and 6-5 overall.
March 8 
 1948 - Jonathan Sacks, former Chief Rabbi of the United Hebrew Congregations of the Commonwealth of Nations
Sunset Boulevard (movie) 
 Sunset Boulevard is a 1950 movie about a screenwriter (William Holden) accompanying a silent movie actress (Gloria Swanson).
Sunset Boulevard (movie) 
 For Andrew Lloyd Webber's musical theater, it starred Patti LuPone, Glenn Close, Betty Buckley and Elaine Paige.
September 26 
 1687  The Parthenon in Athens is partially destroyed by an explosion caused by the bombing from Venetian forces led by Francesco Morosini who are besieging the Ottoman Turks stationed in Athens.
September 26 
 1687  The city council of Amsterdam votes to support William of Orange's invasion of England, later known as the Glorious Revolution.
September 26 
 1786  Protestors shut down the court in Springfield, Massachusetts in a military stand-off that begins the Shays' Rebellion.
September 26 
 1810  The Riksdag (Swedish parliament) passes the Act of Succession, allowing Jean Baptiste Bernadotte to become heir to the throne of Sweden.
September 26 
 1960  The first televised United States Presidential debate takes place, between John F. Kennedy and Richard Nixon.
September 26 
 1970  The Laguna Fire starts in San Diego County, California, burning 175,425 acres (709.92 square kilometers) of land.
September 26 
 1992  A Nigerian troop transporter plane crashes shortly after take-off in Lagos, killing all 163 soldiers on board.
September 26 
 2008  Swiss pilot and inventor Yves Rossy becomes the first person to fly a jet engine-powered wing across the English Channel.
September 26 
 2009  Typhoon Ketsana strikes the Philippines, and several neighboring countries, killing over 700 people.
September 26 
 2017  It is announced that the Republic of Ireland is to hold a referendum on the issue of abortion in 2018.
September 26 
 1886  Archibald Hill, English mathematician, won the 1922 Nobel Prize in Physiology or Medicine (d. 1977)
Molière 
 Later, King Louis XIV made Molière responsible for the entertainment at the court of Versailles near Paris.
Molière 
 Molière was happy to have the king among his friends, because he had many enemies, especially important people in the Roman Catholic church.
Molière 
 By putting his characters in ridiculous situations, Molière wants to entertain and educate his audience.
Molière 
 One of his most important plays is Tartuffe, showing a bigoted man stealing his way into a rich family.
Sealand 
 Sealand is a self-claimed country in the North Sea approximately 7.5 miles from the coast of Suffolk.
Sealand 
 Sealand is a structure called Roughs Tower it was built in the sea by the British Royal Navy, and later became Sealand.
Sealand 
 Even though a man named Michael Bates says Sealand is a country, no other country has supported this claim.
Sealand 
 Sealand defends their claim to being a country due to meeting all four criteria of the Montevideo Convention.
Sealand 
 The owners claim that Sealand is an independent sovereign state because in 1968 an English court decided that Roughs Tower was in international waters and outside the jurisdiction of the British courts.
Sealand 
 In the declaratory theory of statehood, an entity becomes a state as soon as it meets the minimal criteria for statehood.
Sealand 
 Irrespective of its legal status, Sealand is managed by the Bates family as if it were a recognised sovereign entity, and they are its hereditary royal rulers.
Sealand 
 Their son is known as "His Royal Highness Prince Michael" and has been referred to as the "Prince Regent" by the Bates family since 1999.
Sealand 
 In this role, he apparently serves as Sealand's acting "Head of State" and also its "Head of Government".
Sealand 
 At a micronations conference hosted by the University of Sunderland in 2004, Sealand was represented by Michael Bates' son James, who was referred to as "Prince Royal James."
Sealand 
 The facility is now occupied by one or more caretakers representing Michael Bates, who himself resides in Essex, England.
Sealand 
 The preamble asserts Sealand's independence, while the articles variously deal with Sealand's status as a constitutional monarchy, the empowerment of government bureaus, the role of an appointed, advisory senate, the functions of an appointed, advisory legal tribunal, a proscription against the bearing of arms except by members of a designated "Sealand Guard", the exclusive right of the sovereign to formulate foreign policy and alter the constitution, and the hereditary patrilinear succession of the monarchy.
Sealand 
 Sealand's legal system is claimed to follow British common law, and statutes take the form of decrees enacted by the sovereign.
Sealand 
 Sealand has issued passports and has operated as a flag of convenience state, and it also holds the Guinness World Record for "the smallest area to lay claim to nation status".
Sealand 
 It appears on Sealandic items, such as stamps, passports, and coins, and is the title of the Sealandic anthem.
Sticky note 
 A sticky note (or Post-it note) is a small piece of paper with a strip of glue along one edge that make it "sticky," so you can stick it to things.
Sticky note 
 The most common sticky note is the Post-it, which is made by a company called 3M. In 1974 a man named Arthur Fry came up with the idea for the sticky note.
Sticky note 
 He used a glue that was originally too weak to be used for anything else, so the notes would come off easy.
Sticky note 
 In 2001, the patent for the glue that 3M uses on Post-it notes expired, so many other companies now make similar sticky notes.
Becker (TV series) 
 It starred Ted Danson as Dr. John Becker, a very grumpy family doctor who is unhappy with his life in The Bronx, New York.
Becker (TV series) 
 Jake also works at the diner selling newspapers and miscellaneous items such as candy, magazines, cigarettes, gum, etc.
Becker (TV series) 
 He is an old high school classmate of Reggie's who is short, annoying, and refers to himself in the third person.
Ted Danson 
 Ted Danson was nominated for Outstanding Lead Actor in a Comedy Series in 2018, 2019 and 2020 for playing Michael on The Good Place.
Digital camera 
 Most digital cameras can use a USB cable that connects into a computer to send pictures that are in the camera to the computer.
Digital camera 
 Most camera phones do not make as good pictures as larger separate cameras do, especially where light is not bright.
Digital camera 
 The memory device can be internal - flash memory inside the camera, or external - memory cards, microdrives and so on.
Digital camera 
 The picture can be saved in a compressed file (JPEG, TIFF) or in an uncompressed, proprietary RAW file.
Digital camera 
 The compressed picture is lower quality but the RAW picture has to be processed with a special computer program.
Digital camera 
 A video is usually saved as an AVI, MPEG or MOV file format (it depends on the producer of the camera).
Digital camera 
 This metadata information usually includes the date of taking the picture, the camera type, and its settings.
Cheers 
 Cheers is a long-running American sitcom made by Charles-Burrows-Charles Productions in association with Paramount Television for NBC.
Cheers 
 The show premiered on September 30, 1982 and had its widely watched series finale on May 20, 1993, followed by a long and ongoing run in syndication.
Cheers 
 This bar was where a group of friends would come to sit, drink alcohol, complain, and make practical jokes on a rival bar in town.
Cheers 
 The show's main theme in its early seasons was the romance between Diane Chambers (Shelley Long) and ex-baseball pitcher and bar owner Sam Malone (Ted Danson).
Cheers 
 Long's departure from the show in 1987 shifted the emphasis to Sam's relationship with a new character, Rebecca Howe (Kirstie Alley).
Cheers 
 Frasier's love interest Lilith Sternin appeared on both shows but Frasier and Lilith were no longer married in Frasier.
Cheers 
 The producers, not wanting the show to be construed as promoting drinking, had Sam's character written as an ex-alcoholic.
Cheers 
 The outer shots of the bar were actually the Bull and Finch pub, north of Boston Common, which has become a tourist attraction because of its association with the series.
Cheers 
 It is said to be the bar that the series creators saw and wanted to model the bar in their show after.
Cheers 
 It has now been renamed Cheers on Beacon Hill, though its interior is quite different from the TV bar.
Cheers 
 But it eventually became one of the most popular shows on TV because it had a top-ten rating during seven of its eleven seasons.
Jackie Chan Adventures 
 Episodes were first broadcast on the WB television network, and later syndicated on other networks such as the Cartoon Network.