tbuckley/cabot-search huggingface dataset:
Long term exposure to road traffic noise and air pollution and risk of infertility in men and women: nationwide Danish cohort study
Authors: Mette Sørensen, Aslak Harbo Poulsen, Bugge Nøhr, Jibran Khan, Matthias Ketzel, Jørgen Brandt, Ole Raaschou-Nielsen, Allan Jensen
Journal: BMJ (2024)

Abstract Objective To investigate associations between long term residential exposure to road traffic noise and particulate matter with a diameter &lt;2.5 µm (PM 2.5 ) and infertility in men and women. Design Nationwide prospective cohort study. Setting Denmark. Participants 526 056 men and 377 850 women aged 30-45 years, with fewer than two children, cohabiting or married, and residing in Denmark between 2000 and 2017. Main outcome measure Incident infertility in men and women during follow-up in the Danish National Patient Register. Results Infertility was diagnosed in 16 172 men and 22 672 women during a mean follow-up of 4.3 years and 4.2 years, respectively. Mean exposure to PM 2.5 over five years was strongly associated with risk of infertility in men, with hazard ratios of 1.24 (95% confidence interval 1.18 to 1.30) among men aged 30-36.9 years and 1.24 (1.15 to 1.33) among men aged 37-45 years for each interquartile (2.9 µg/m 3 ) higher PM 2.5 after adjustment for sociodemographic variables and road traffic noise. PM 2.5 was not associated with infertility in women. Road traffic noise (Lden, most exposed facade of residence) was associated with a higher risk of infertility among women aged 35-45 years, with a hazard ratio of 1.14 (1.10 to 1.18) for each interquartile (10.2 dB) higher five year mean exposure. Noise was not associated with infertility among younger women (30-34.9 years). In men, road traffic noise was associated with higher risk of infertility in the 37-45 age group (1.06, 1.02 to 1.11), but not among those aged 30-36.9 years (0.93, 0.91 to 0.96). Conclusions PM 2.5 was associated with a higher risk of an infertility diagnosis in men, whereas road traffic noise was associated with a higher risk of an infertility diagnosis in women older than 35 years, and potentially in men older than 37 years. If these results are confirmed in future studies, higher fertility could be added to the list of health benefits from regulating noise and air pollution.
Bacterial sexually transmitted infections among men who have sex with men and transgender women using oral pre-exposure prophylaxis in Latin America (ImPrEP): a secondary analysis of a prospective, open-label, multicentre study
Authors: Mayara Secco Torres Silva, Thiago Silva Torres, Carolina Coutinho, Ronaldo Ismério Moreira, Iuri da Costa Leite, Marcelo Cunha, Pedro Henrique Amparo da Costa Leite, Carlos F Cáceres, Hamid Vega-Ramírez, Kelika A Konda, Juan Guanira, José Valdez Madruga, Sandra Wagner Cardoso, Marcos Benedetti, Maria Cristina Pimenta, Brenda Hoagland, Beatriz Grinsztejn, Valdilea Gonçalves Veloso
Journal: The Lancet HIV (2024)
Rituximab and mycophenolate mofetil in interstitial lung disease (EVER-ILD): one-year follow up results of a randomized controlled trial
Authors: Laurène Mansy, Agnès Caille, Martine Reynaud-Gaubert, Julien Bermudez, Philippe Bonniaud, Raphael Borie, Pierre-Yves Brillet, Jacques Cadranel, Isabelle Court-Fortune, Bruno Crestani, Marie-Pierre Debray, Mathilde Duprez, Anne Guillaumot, Sandrine Hirschi-Santelmo, Dominique Israel-Biet, Stéphane Jouneau, Karine Juvin, Mallorie Kerjouan, Julie Mankikian, Charles-Hugo Marquette, Jean-Marc Naccache, Hilario Nunes, Laurent Plantier, Grégoire Prevot, Sébastien Quetant, Julie Traclet, Victor Valentin, Yurdagul Uzunhan, Lidwine Wémeau-Stervinou, Vincent Cottin, Sylvain Marchand-Adam
Journal: European Respiratory Journal (2024)
Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus
Authors: Diana Fatykhova, Verena N Fritsch, Keerthana Siebert, Karen Methling, Michael Lalk, Tobias Busche, Jörn Kalinowski, January Weiner, Dieter Beule, Wilhelm Bertrams, Thomas P Kohler, Sven Hammerschmidt, Anna Löwa, Mara Fischer, Maren Mieth, Katharina Hellwig, Doris Frey, Jens Neudecker, Jens C Rueckert, Mario Toennies, Torsten T Bauer, Mareike Graff, Hong-Linh Tran, Stephan Eggeling, Achim D Gruber, Haike Antelmann, Stefan Hippenstiel, Andreas C Hocke
Journal: European Respiratory Journal (2024)

Streptococcus pneumoniae ( S.p. ) is the most common causative agent of community-acquired pneumonia worldwide. A key pathogenic mechanism that exacerbates severity of disease is the disruption of the alveolar-capillary barrier. However, the specific virulence mechanisms responsible for this in the human lung are not yet fully understood. In this study, we infected living human lung tissue with S.p. and observed a significant degradation of the central junctional proteins occludin and VE-cadherin, indicating barrier disruption. Surprisingly, neither pneumolysin, bacterial hydrogen peroxide nor pro-inflammatory activation were sufficient to cause this junctional degradation. Instead, pneumococcal infection led to a significant decrease of pH (approximately 6), resulting in acidification of the alveolar microenvironment, which was linked to junctional degradation. Stabilising the pH at physiological levels during infection reversed this effect, even in a therapeutic-like approach. Further analysis of bacterial metabolites and RNA sequencing revealed sugar consumption and subsequent lactate production were the major factors contributing to bacterially induced alveolar acidification, which also hindered the release of critical immune factors. Our findings highlight bacterial metabolite-induced acidification as an independent virulence mechanism for barrier disruption and inflammatory dysregulation in pneumonia. Thus, our data suggest that strictly monitoring and buffering alveolar pH during infections caused by fermentative bacteria could serve as an adjunctive therapeutic strategy for sustaining barrier integrity and immune response.
A novel<i>in vitro</i>tubular model to recapitulate features of distal airways: The bronchioid
Authors: Elise Maurat, Katharina Raasch, Alexander M Leipold, Pauline Henrot, Maeva Zysman, Renaud Prevel, Thomas Trian, Tobias Krammer, Vanessa Bergeron, Matthieu Thumerel, Pierre Nassoy, Patrick Berger, Antoine-Emmanuel Saliba, Laetitia Andrique, Gaëlle Recher, Isabelle Dupin
Journal: European Respiratory Journal (2024)

Background Airflow limitation is the hallmark of obstructive pulmonary diseases, with the distal airways representing a major site of obstruction. Although numerous in vitro models of bronchi already exist, there is currently no culture system for obstructive diseases that reproduces the architecture and function of small airways. Here, we aimed to engineer a model of distal airways to overcome the limitations of current culture systems. Methods We developed a so-called bronchioid model by encapsulating human bronchial adult stem cells derived from clinical samples in a tubular scaffold made of alginate gel. Results This template drives the spontaneous self-organisation of epithelial cells into a tubular structure. Fine control of the level of contraction is required to establish a model of the bronchiole, which has a physiologically relevant shape and size. 3D imaging, gene expression and single-cell RNA-seq analysis of bronchioids made of bronchial epithelial cells revealed tubular organisation, epithelial junction formation and differentiation into ciliated and goblet cells. Ciliary beating is observed, at a decreased frequency in bronchioids made of cells from COPD patients. The bronchioid can be infected by rhinovirus. An air-liquid interface is introduced that modulates gene expression. Conclusion Here, we provide a proof of concept of a perfusable bronchioid with proper mucociliary and contractile functions. The key advantages of our approach, such as the air‒liquid interface, lumen accessibility, recapitulation of pathological features and possible assessment of clinically relevant endpoints, will make our pulmonary organoid-like model a powerful tool for preclinical studies.
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies
Authors: William O. Hahn, K. Rachael Parks, Mingchao Shen, Gabriel Ozorowski, Holly Janes, Lamar Ballweber-Fleming, Amanda S. Woodward Davis, Chris Duplessis, Mark Tomai, Antu K. Dey, Zachary K. Sagawa, Stephen C. De Rosa, Aaron Seese, Latha Kallur Siddaramaiah, Leonidas Stamatatos, Wen-Hsin Lee, Leigh M. Sewall, Dalton Karlinsey, Hannah L. Turner, Vanessa Rubin, Sarah Furth, Kellie MacPhee, Michael Duff, Lawrence Corey, Michael C. Keefer, Srilatha Edupuganti, Ian Frank, Janine Maenza, Lindsey R. Baden, Ollivier Hyrien, Rogier W. Sanders, John P. Moore, Andrew B. Ward, Georgia D. Tomaras, David C. Montefiori, Nadine Rouphael, M. Juliana McElrath
Journal: The Journal of Experimental Medicine (2024)

Stabilized trimers preserving the native-like HIV envelope structure may be key components of a preventive HIV vaccine regimen to induce broadly neutralizing antibodies (bnAbs). We evaluated trimeric BG505 SOSIP.664 gp140 formulated with a novel TLR7/8 signaling adjuvant, 3M-052-AF/Alum, for safety, adjuvant dose-finding, and immunogenicity in a first-in-healthy adult (n = 17), randomized, and placebo-controlled trial (HVTN 137A). The vaccine regimen appeared safe. Robust, trimer-specific antibody, and B cell and CD4+ T cell responses emerged after vaccination. Five vaccinees developed serum autologous tier 2 nAbs (ID50 titer, 1:28-1:8647) after two to three doses targeting C3/V5 and/or V1/V2/V3 Env regions by electron microscopy and mutated pseudovirus-based neutralization analyses. Trimer-specific, B cell–derived monoclonal antibody activities confirmed these results and showed weak heterologous neutralization in the strongest responder. Our findings demonstrate the clinical utility of the 3M-052-AF/Alum adjuvant and support further improvements of trimer-based Env immunogens to focus responses on multiple broad nAb epitopes.
EGFR-targeting oxygen-saturated nanophotosensitizers for orchestrating multifaceted antitumor responses by counteracting immunosuppressive milieu
Authors: Yuan He, Deng Wang, Cheng Zhang, Siting Huang, Xiangzheng Li, Yue Chen, Yuanyuan Ma, Shenghong Ju, Hongxun Ye, Wenpei Fan
Journal: Journal of Controlled Release (2024)
Epigenetics Research in Evolutionary Biology: Perspectives on Timescales and Mechanisms
Authors: Soojin V Yi
Journal: Molecular Biology and Evolution (2024)

Epigenetics research in evolutionary biology encompasses a variety of research areas, from regulation of gene expression to inheritance of environmentally mediated phenotypes. Such divergent research foci can occasionally render the umbrella term "epigenetics" ambiguous. Here I discuss several areas of contemporary epigenetics research in the context of evolutionary biology, aiming to provide balanced views across timescales and molecular mechanisms. The importance of epigenetics in development is now being assessed in many nonmodel species. These studies not only confirm the importance of epigenetic marks in developmental processes, but also highlight the significant diversity in epigenetic regulatory mechanisms across taxa. Further, these comparative epigenomic studies have begun to show promise toward enhancing our understanding of how regulatory programs evolve. A key property of epigenetic marks is that they can be inherited along mitotic cell lineages, and epigenetic differences that occur during early development can have lasting consequences on the organismal phenotypes. Thus, epigenetic marks may play roles in short-term (within an organism's lifetime or to the next generation) adaptation and phenotypic plasticity. However, the extent to which observed epigenetic variation occurs independently of genetic influences remains uncertain, due to the widespread impact of genetics on epigenetic variation and the limited availability of comprehensive (epi)genomic resources from most species. While epigenetic marks can be inherited independently of genetic sequences in some species, there is little evidence that such "transgenerational inheritance" is a general phenomenon. Rather, molecular mechanisms of epigenetic inheritance are highly variable between species.
Postbiotic impact on host metabolism and immunity provides therapeutic potential in metabolic disease
Authors: Han Fang, Rodrigo Rodrigues e-Lacerda, Nicole G Barra, Dana Kukje Zada, Nazli Robin, Alina Mehra, Jonathan D Schertzer
Journal: Endocrine Reviews (2024)

Abstract The gut microbiota influences aspects of metabolic disease, including tissue inflammation, adiposity, blood glucose, insulin, and endocrine control of metabolism. Prebiotics or probiotics are often sought to combat metabolic disease. However, prebiotics lack specificity and can have deleterious bacterial community effects. Probiotics require live bacteria to find a colonization niche sufficient to influence host immunity or metabolism. Postbiotics encompass bacterial-derived components and molecules, which are well-positioned to alter host immunometabolism without relying on colonization efficiency or causing widespread effects on the existing microbiota. Here, we summarize the potential for beneficial and detrimental effects of specific postbiotics related to metabolic disease and the underlying mechanisms of action. Bacterial cell wall components, such as lipopolysaccharides, muropeptides, lipoteichoic acids and flagellin, have context-dependent effects on host metabolism by engaging specific immune responses. Specific types of postbiotics within broad classes of compounds, such as lipopolysaccharides and muropeptides, can have opposing effects on endocrine control of host metabolism, where certain postbiotics are insulin sensitizers and others promote insulin resistance. Bacterial metabolites, such as short-chain fatty acids, bile acids, lactate, glycerol, succinate, ethanolamine, and ethanol, can be substrates for host metabolism. Postbiotics can fuel host metabolic pathways directly or influence endocrine control of metabolism through immunomodulation or mimicking host-derived hormones. The interaction of postbiotics in the host-microbe relationship should be considered during metabolic inflammation and metabolic disease.
Five miRNAs identified in fucosylated extracellular vesicles as non-invasive diagnostic signatures for hepatocellular carcinoma
Authors: Boan Li, Kun Hao, Mengyang Li, Ailan Wang, Huixue Tang, Lida Xu, Cuidie Ma, Wenqian Du, Lijuan Sun, Xufeng Hou, Tianye Jia, Aixia Liu, Qi Gao, Zhiming Zhao, Ronghua Jin, Ruifu Yang
Journal: Cell Reports Medicine (2024)
Ixazomib as consolidation and maintenance versus observation in patients with relapsed multiple myeloma eligible for salvage autologous stem-cell transplantation (Myeloma XII [ACCoRD]): interim analysis of a multicentre, open-label, randomised, phase 3 trial
Authors: Gordon Cook, A John Ashcroft, Ethan Senior, Catherine Olivier, Anna Hockaday, Jeanine Richards, Jamie D Cavenagh, John A Snowden, Mark T Drayson, Ruth de Tute, Lesley Roberts, Roger G Owen, Kwee Yong, Mamta Garg, Kevin Boyd, Hamdi Sati, Sharon Gillson, Mark Cook, David A Cairns, Christopher Parrish
Journal: The Lancet Haematology (2024)
Competency-based training and supervision: development of the WHO-UNICEF Ensuring Quality in Psychosocial and Mental Health Care (EQUIP) initiative
Authors: Brandon A Kohrt, Gloria A Pedersen, Alison Schafer, Kenneth Carswell, Fiamma Rupp, Mark J D Jordans, Elise West, Josephine Akellot, Pamela Y Collins, Carmen Contreras, Jerome T Galea, Frezgi Gebrekristos, Muthoni Mathai, Kristina Metz, Naser Morina, Mwamba Mwila Mwenge, Frederik Steen, Ann Willhoite, Mark van Ommeren, James Underhill
Journal: The Lancet Psychiatry (2024)
Islet-after-kidney transplantation versus kidney alone in kidney transplant recipients with type 1 diabetes (KAIAK): a population-based target trial emulation in France
Authors: Mehdi Maanaoui, Rémi Lenain, Yohann Foucher, Fanny Buron, Gilles Blancho, Corinne Antoine, Sophie Caillard, Laurence Kessler, Moglie Le Quintrec, Orianne Villard, Dany Anglicheau, Matthias Büchler, Albane Brodin-Sartorius, Luc Frimat, Paolo Malvezzi, Sandrine Lablanche, Lionel Badet, Laure Esposito, Mikael Chetboun, Aghiles Hamroun, Julie Kerr-Conte, Thierry Berney, Marie-Christine Vantyghem, Marc Hazzan, François Pattou
Journal: The Lancet Diabetes & Endocrinology (2024)
Sodium–glucose co-transporter-2 inhibitors for hospitalised patients with COVID-19: a prospective meta-analysis of randomised trials
Authors: Claire Vale, Peter J Godolphin, David Fisher, Peter W Horby, Mikhail N Kosiborod, Judith S Hochman, Katie Webster, Julian P T Higgins, Andrew D Althouse, Otavio Berwanger, Remo H M Furtado, Samvel B Gasparyan, Richard Haynes, Gary G Koch, Martin Landray, Eric Leifer, John Marshall, Srinivas Murthy, Matthew D Neal, Natalie Staplin, Janet Diaz, Jonathan A C Sterne, Manu Shankar-Hari
Journal: The Lancet Diabetes & Endocrinology (2024)
Prevalence of Chagas disease among Latin American immigrants in non-endemic countries: an updated systematic review and meta-analysis
Authors: Gisele Nepomuceno de Andrade, Pau Bosch-Nicolau, Bruno R Nascimento, Francisco Rogerlândio Martins-Melo, Pablo Perel, Yvonne Geissbühler, Caroline Demacq, Monica Quijano, Jonathan F Mosser, Ewerton Cousin, Ísis Eloah Machado, Matheus Lucca A C Rodrigues, Antonio Luiz P Ribeiro, Israel Molina
Journal: The Lancet Regional Health - Europe (2024)
Effect of sodium–glucose co-transporter-2 inhibitors on survival free of organ support in patients hospitalised for COVID-19 (ACTIV-4a): a pragmatic, multicentre, open-label, randomised, controlled, platform trial
Authors: Mikhail N Kosiborod, Sheryl L Windsor, Orly Vardeny, Jeffrey S Berger, Harmony R Reynolds, Stavroula Boumakis, Andrew D Althouse, Scott D Solomon, Ankeet S Bhatt, Alexander Peikert, James F Luther, Eric S Leifer, Andrei L Kindzelski, Mary Cushman, Michelle Ng Gong, Lucy Z Kornblith, Pooja Khatri, Keri S Kim, Lisa Baumann Kreuziger, Ali Javaheri, Carlos Carpio, Lana Wahid, Jose Lopez-Sendon Moreno, Alvaro Alonso, Minh Quang Ho, Jose Lopez-Sendon, Renato D Lopes, Jeffrey L Curtis, Bridget-Anne Kirwan, Mark W Geraci, Matthew D Neal, Judith S Hochman
Journal: The Lancet Diabetes & Endocrinology (2024)
Antecedent and persistent symptoms in COVID-19 and other respiratory illnesses: insights from prospectively collected data in the BRACE trial
Authors: Ellie McDonald, Laure F Pittet, Simone E Barry, Marc Bonten, John Campbell, Julio Croda, Mariana G Croda, Margareth Pretti Dalcolmo, Andrew Davidson, Fernando F de Almeida E Val, Ms Glauce Dos Santos, Ms Kaya Gardiner, Ms Grace Gell, Amanda Gwee, Ms Ann Krastev, Marcus Vinícius Guimaraes Lacerda, Michaela Lucas, David J Lynn, Laurens Manning, Mr Nick McPhate, Kirsten P Perrett, Jeffrey J Post, Cristina Prat-Aymerich, Ms Lynne E Quinn, Peter C Richmond, Nicholas J Wood, Nicole L Messina, Nigel Curtis
Journal: Journal of Infection (2024)
STING-activating dendritic cell-targeted nanovaccines that evoke potent antigen cross-presentation for cancer immunotherapy
Authors: Nguyen Thi Nguyen, Xuan Thien Le, Woo Tak Lee, Yong Taik Lim, Kyung Taek Oh, Eun Seong Lee, Han-Gon Choi, Yu Seok Youn
Journal: Bioactive Materials (2024)
Low-dose computed tomography perceptual image quality assessment
Authors: Wonkyeong Lee, Fabian Wagner, Adrian Galdran, Yongyi Shi, Wenjun Xia, Ge Wang, Xuanqin Mou, Md Atik Ahamed, Abdullah Al Zubaer Imran, Ji Eun Oh, Kyungsang Kim, Jong Tak Baek, Dongheon Lee, Boohwi Hong, Philip Tempelman, Donghang Lyu, Adrian Kuiper, Lars van Blokland, Maria Baldeon Calisto, Scott Hsieh, Minah Han, Jongduk Baek, Andreas Maier, Adam Wang, Garry Evan Gold, Jang-Hwan Choi
Journal: Medical Image Analysis (2024)
The role of CFTR in the eye, and the effect of early highly effective modulator treatment for cystic fibrosis on eye health
Authors: Elena K Schneider-Futschik, Yimin Zhu, Danni Li, Mark D Habgood, Bao N Nguyen, Ines Pankonien, Margarida D Amaral, Laura E Downie, Holly R Chinnery
Journal: Progress in Retinal and Eye Research (2024)
Motoric Cognitive Risk Syndrome As A Predictive Factor of Cognitive Impairment and Dementia – A Systematic Review and Meta-Analysis
Authors: Nicholas E-Kai Lim, Brian Sheng Yep Yeo, Rachel Siying Lee, Jun Xiang Lim, Yiong Huak Chan, Nagaendran Kandiah, Roger Ho, Cyrus Su Hui Ho, Jean Woo, Hidenori Arai, Reshma Aziz Merchant
Journal: Ageing Research Reviews (2024)
mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity
Authors: Laurie L Kenney, Rebecca Suet-Yan Chiu, Michelle N Dutra, Alexandra Wactor, Chris Honan, Lukas Shelerud, Joshua J Corrigan, Kelly Yu, Joseph D Ferrari, Kate L Jeffrey, Eric Huang, Paul L Stein
Journal: Cell Reports Medicine (2024)
Mother’s milk microbiota is associated with the developing gut microbial consortia in very-low-birth-weight infants
Authors: Sara Shama, Michelle R Asbury, Alex Kiss, Nicole Bando, James Butcher, Elena M Comelli, Julia K Copeland, Adrianna Greco, Akash Kothari, Philip M Sherman, Alain Stintzi, Amel Taibi, Christopher Tomlinson, Sharon Unger, Pauline W Wang, Deborah L O'Connor
Journal: Cell Reports Medicine (2024)
SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation
Authors: Wenhui Liu, Danming You, Jiayang Lin, Huren Zou, Lei Zhang, Shenjian Luo, Youwen Yuan, Zhiyi Wang, Jingwen Qi, Weiwei Wang, Xueru Ye, Xiaoyu Yang, Yajuan Deng, Fei Teng, Xiaojun Zheng, Yuhao Lin, Zhiwei Huang, Yan Huang, Zhi Yang, Xuan Zhou, Yanan Zhang, Ruxin Chen, Lingling Xu, Jin Li, Wei Yang, Huijie Zhang
Journal: Cell Metabolism (2024)
Intestinal newborn regulatory B cell antibodies modulate microbiota communities
Authors: Qisheng Gu, Marion Draheim, Cyril Planchais, Zihan He, Fan Mu, Shijie Gong, Chun Shen, Haitao Zhu, Dania Zhivaki, Khashayar Shahin, Jean-Marc Collard, Min Su, Xiaoming Zhang, Hugo Mouquet, Richard Lo-Man
Journal: Cell Host & Microbe (2024)
Paneth cell TNF signaling induces gut bacterial translocation and sepsis
Authors: Charlotte Wallaeys, Natalia Garcia-Gonzalez, Steven Timmermans, Jolien Vandewalle, Tineke Vanderhaeghen, Somara De Beul, Hester Dufoor, Melanie Eggermont, Elise Moens, Victor Bosteels, Riet De Rycke, Fabien Thery, Francis Impens, Serge Verbanck, Stefan Lienenklaus, Sophie Janssens, Richard S Blumberg, Takao Iwawaki, Claude Libert
Journal: Cell Host & Microbe (2024)
Imlunestrant, an Oral Selective Estrogen Receptor Degrader, as Monotherapy and in Combination With Targeted Therapy in Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer: Phase Ia/Ib EMBER Study
Authors: Komal L. Jhaveri, Elgene Lim, Rinath Jeselsohn, Cynthia X. Ma, Erika P. Hamilton, Cynthia Osborne, Manali Bhave, Peter A. Kaufman, J. Thaddeus Beck, Luis Manso Sanchez, Ritesh Parajuli, Hwei-Chung Wang, Jessica J. Tao, Seock-Ah Im, Kathleen Harnden, Kan Yonemori, Ajay Dhakal, Patrick Neven, Philippe Aftimos, Jean-Yves Pierga, Yen-Shen Lu, Timothy Larson, Yolanda Jerez, Kostandinos Sideras, Joohyuk Sohn, Sung-Bae Kim, Cristina Saura, Aditya Bardia, Sarah L. Sammons, Francesca Bacchion, Yujia Li, Eunice Yuen, Shawn T. Estrem, Vanessa Rodrik-Outmezguine, Bastien Nguyen, Roohi Ismail-Khan, Lillian Smyth, Muralidhar Beeram
Journal: Journal of Clinical Oncology (2024)

Imlunestrant is a next-generation oral selective estrogen receptor (ER) degrader designed to deliver continuous ER target inhibition, including in