tbuckley/cabot-search huggingface dataset:
Progress in the Computer‐aided Analysis in Multiple Aspects of Nanocatalysis Research
Authors: Lin Fan, Yilei Shen, Doudou Lou, Ning Gu
Journal: Advanced Healthcare Materials (2024)

Making the utmost of the differences and advantages of multiple disciplines, interdisciplinary integration breaks the science boundaries and accelerates the progress in mutual quests. As an organic connection of material science, enzymology, and biomedicine, nanozyme-related research is further supported by computer technology, which injects in new vitality, and contributes to in-depth understanding, unprecedented insights, and broadened application possibilities. Utilizing computer-aided first-principles method, high-speed and high-throughput mathematic, physic, and chemic models are introduced to perform atomic-level kinetic analysis for nanocatalytic reaction process, and theoretically illustrate the underlying nanozymetic mechanism and structure-function relationship. On this basis, nanozymes with desirable properties can be designed and demand-oriented synthesized without repeated trial-and-error experiments. Besides that, computational analysis and device also play an indispensable role in nanozyme-based detecting methods to realize automatic readouts with improved accuracy and reproducibility. Here, this work focuses on the crossing of nanocatalysis research and computational technology, to inspire the research in computer-aided analysis in nanozyme field to a greater extent.
Prognostic value of tissue bridges in cervical spinal cord injury: a longitudinal, multicentre, retrospective cohort study
Authors: Dario Pfyffer, Andrew C Smith, Kenneth A Weber, Andreas Grillhoesl, Orpheus Mach, Christina Draganich, Jeffrey C Berliner, Candace Tefertiller, Iris Leister, Doris Maier, Jan M Schwab, Alan Thompson, Armin Curt, Patrick Freund
Journal: The Lancet Neurology (2024)
Temporal trends in the prevalence of Parkinson's disease from 1980 to 2023: a systematic review and meta-analysis
Authors: Jinqiao Zhu, Yusha Cui, Junjiao Zhang, Rui Yan, Dongning Su, Dong Zhao, Anxin Wang, Tao Feng
Journal: The Lancet Healthy Longevity (2024)

Parkinson's disease is the second most common neurodegenerative disorder, exhibiting an upward trend in prevalence. We aimed to investigate the prevalence of Parkinson's disease, temporal trends between 1980 and 2023, and variations in prevalence by location, age, sex, survey period, sociodemographic index (SDI), human development index (HDI), and study characteristics (sample size, diagnostic criteria, and data source).
Response to Zhong et al.
Authors: Noriko Nishiyama, Hideki Kobara
Journal: Endoscopy (2024)

Letter to: Comments on "Novel strategy of hold-and-drag clip closure with mantis-like claw for post-gastric endoscopic submucosal dissection defect of <30 mm"Endoscopy 2024; 56(07): 550-550DOI: 10.1055/a-2256-0063
Comments on “Novel strategy of hold-and-drag clip closure with mantis-like claw for post-gastric endoscopic submucosal dissection defect of &lt;30 mm”
Authors: Chengqian Zhong, Tiantian Cao, Shiqian Lan
Journal: Endoscopy (2024)

Letter to: Novel strategy of hold-and-drag clip closure with mantis-like claw for post-gastric endoscopic submucosal dissection defect of <30 mmEndoscopy 2023; 55(S 01): E1244-E1245DOI: 10.1055/a-2213-4313
Visualized biliary cannulation during ERCP: future trends
Authors: Xin-yu Huang, Wei-hui Liu, Xiao Hu, Xiao-gang Liu
Journal: Endoscopy (2024)

Letter to: Visualized biliary cannulation during ERCP: do we really need it?Endoscopy 2024; 56(07): 551-552DOI: 10.1055/a-2234-8599
Frailty progression in adults aged 40 years and older in rural Burkina Faso: a longitudinal, population-based study
Authors: Dina Goodman-Palmer, Carolyn Greig, Sandra Agyapong-Badu, Miles D Witham, Collin F Payne, Mamadou Bountogo, Boubacar Coulibaly, Pascal Geldsetzer, Guy Harling, Maxime Inghels, Jennifer Manne-Goehler, Lucienne Ouermi, Ali Sie, Justine I Davies
Journal: The Lancet Healthy Longevity (2024)
Association of intrinsic capacity with functional decline and mortality in older adults: a systematic review and meta-analysis of longitudinal studies
Authors: Juan Luis Sánchez-Sánchez, Wan-Hsuan Lu, Daniel Gallardo-Gómez, Borja del Pozo Cruz, Philipe de Souto Barreto, Alejandro Lucia, Pedro L Valenzuela
Journal: The Lancet Healthy Longevity (2024)
Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial
Authors: Jiamin Liu, Yan Li, Jinzhuo Ge, Xiaofang Yan, Haibo Zhang, Xin Zheng, Jiapeng Lu, Xi Li, Yan Gao, Lubi Lei, Jing Liu, Jing Li
Journal: The Lancet (2024)
Optimizing thiopurine therapy in autoimmune hepatitis: A multicenter study on monitoring metabolite profiles and co-therapy with allopurinol
Authors: Yooyun Chung, None Ergenc, Michael A. Heneghan
Journal: Hepatology (2024)

1School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK 2Institute of Liver Studies, King's College Hospital, London, SE5 9RS, UK Correspondence Michael A. Heneghan, Consultant Hepatologist and Professor of Hepatology, Institute of Liver Studies, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, United Kingdom. Email: [email protected]
Integrated and collaborative care across the spectrum of alcohol-associated liver disease and alcohol use disorder
Authors: Lamia Y. Haque, Lorenzo Leggio
Journal: Hepatology (2024)

The public health impact of alcohol-associated liver disease (ALD), a serious consequence of problematic alcohol use, and alcohol use disorder (AUD) is growing, with ALD becoming a major cause of alcohol-associated death overall and the leading indication for liver transplantation in the United States. Comprehensive care for ALD often requires treatment of AUD. Although there is a growing body of evidence showing that AUD treatment is associated with reductions in liver-related morbidity and mortality, only a minority of patients with ALD and AUD receive this care. Integrated and collaborative models that streamline both ALD and AUD care for patients with ALD and AUD are promising approaches to bridge this treatment gap and rely on multidisciplinary and interprofessional teams and partnerships. Here, we review the role of AUD care in ALD treatment, the effects of AUD treatment on liver-related outcomes, the impact of comorbid conditions such as other substance use disorders, obesity, and metabolic syndrome, and the current landscape of integrated and collaborative care for ALD and AUD in various treatment settings. We further review knowledge gaps and unmet needs that remain, including the role of precision medicine, the application of harm reduction approaches, the impact of health disparities, and the need for additional AUD treatment options, as well as further efforts to support implementation and dissemination.
Reply: Refining retrieval and chunking strategies for enhanced clinical reliability of large language models in liver disease
Authors: Jin Ge, Steve Sun, Joseph Owens, Victor Galvez, Oksana Gologorskaya, Jennifer C. Lai, Mark J. Pletcher, Ki Lai
Journal: Hepatology (2024)

Ge, Jin; Sun, Steve; Owens, Joseph; Galvez, Victor; Gologorskaya, Oksana; Lai, Jennifer C.; Pletcher, Mark J.; Lai, Ki Author Information
Antibiotic prophylaxis for surgical wound infections in clean and clean-contaminated surgery: an updated systematic review and meta-analysis
Authors: Xiao-Fei Tang, Xiang Bin, Ke-Yi Qu, Hong-Jun Liu, Haike Lei, Wei-Fan Li, Zhou Min, Yu Xia, Li-Hua Dai, Su-Ying Yu, Yun-Ping Bao, Jia-Quan Zhu, Tan Bing
Journal: International Journal of Surgery (2024)

The efficacy and necessity of prophylactic antibiotics in clean and clean-contaminated surgery remains controversial.
Neoadjuvant chemoimmunotherapy in resectable locally advanced oral squamous cell carcinoma: a single-center retrospective cohort study
Authors: Bowen Li, Shule Xie, Jingjing Han, Haotian Cao, Zhaoyu Lin, Huijun Hu, Chaobin Pan, Qunxing Li, Jintao Li, Liansheng Wang, Suling Chen, Guangxin Rao, Guoxin Huang, Yongmei Tan, Rongxi Chen, Song Fan, Xiaohui Duan, Haigang Li, Jinsong Li
Journal: International Journal of Surgery (2024)

Background: Surgery and postoperative adjuvant therapy is the standard treatment for locally advanced resectable oral squamous cell carcinoma (OSCC), while neoadjuvant chemoimmunotherapy (NACI) is believed to lead better outcomes. This study aims to investigate the effectiveness of NACI regimens in treating locally advanced resectable OSCC. Materials and methods: Patients diagnosed with locally advanced resectable OSCC who received NACI and non-NACI were reviewed between December 2020 and June 2022 in our single center. The pathologic response was evaluated to the efficacy of NACI treatment. Adverse events apparently related to NACI treatment were graded by Common Terminology Criteria for Adverse Events, version 5.0. Disease-free survival (DFS) and overall survival (OS) rate were assessed. Results: Our analysis involved 104 patients who received NACI. Notably, the pathological complete response (PCR) rate was 47.1%, and the major pathological response (MPR) rate was 65.4%. The top three grade 1-2 treatment-related adverse events (TRAEs) were alopecia (104; 100%), anemia (81; 77.9%) and pruritus (62; 59.6%). Importantly, patients achieving MPR exhibited higher programmed cell death-ligand 1 (PD-L1) combined positive score (CPS). The diagnostic value of CPS as a biomarker for NACI efficacy was enhanced when combined total cholesterol level. The 3-year estimated DFS rates were 89.0% in the NACI cohort compared to 60.8% in the non-NACI cohort, while the 3-year estimated OS rates were 91.3% versus 64.0%, respectively. Conclusions: The NACI treatment showed safe and encouragingly efficacious for locally advanced resectable OSCC patients. The high response rates and favorable prognosis suggest this approach as a potential treatment option. Prospective randomized controlled trials are needed to further validate these findings.
Effect of metformin on hepatocellular carcinoma patients with type II diabetes receiving transarterial chemoembolization: a multicenter retrospective cohort study
Authors: Lei Chen, Linxia Wu, Lijie Zhang, Bo Sun, Wenlong Wu, Yu Lei, Licheng Zhu, Tao Sun, Bin Liang, Huangxuan Zhao, Chuansheng Zheng
Journal: International Journal of Surgery (2024)

Background: Diabetes is prevalent among patients with hepatocellular carcinoma (HCC) and is associated with a poor prognosis. Although the hypoglycemic drug metformin has shown anti-tumor effects, its potential positive effect on patients with HCC and diabetes undergoing transarterial chemoembolization (TACE) remains unclear. Therefore, this study aimed to investigate the efficacy and safety of metformin in patients with HCC and type II diabetes who are receiving TACE. Materials and methods: This retrospective study involved 372 consecutive patients with HCC and type II diabetes across three medical centers between January 2014 and June 2021. All patients underwent TACE. Propensity score matching (PSM) was used to reduce selection bias. Cox proportional hazards regression was employed to compare all-cause death between the metformin and non-metformin groups, while competing risk regression was performed to assess cancer-specific death. Results: Among 372 patients included in the study, 208 patients (177 male patients and 31 female patients) with mean age 59.6 (10.3) years received metformin and 164 patients (139 male patients and 25 female patients) with mean age 60.3 (10.0) years did not. Before PSM, patients with metformin had significantly longer median overall survival (mOS) and median progression-free survival (mPFS) than those without metformin (mOS: 34 months, 95% CI: 25.6–42.4 vs. 20 months, 95% CI: 15.3–24.7; P &lt;0.001; mPFS: 11 months, 95% CI: 9.3–12.7 vs. 8 months, 95% CI: 5.9–10.1; P &lt;0.001). Similar results were observed after PSM. Multivariate regression analysis indicated that metformin was associated with a reduced risk of all-cause mortality (HR: 0.589, 95% CI: 0.454–0.763; P &lt;0.001) and tumor progression (HR: 0.667, 95% CI: 0.526–0.845; P =0.001) before PSM. After excluding deaths related to other factors, metformin continued to demonstrate a reduction in cancer-specific mortality risk among the patients. Subgroup analysis further revealed that patients using metformin had lower all-cause mortality risk and tumor progression risk than those without metformin in most subgroups. Adverse event evaluation suggested that metformin could lead to elevated nausea incidence. Conclusion: Metformin may confer survival benefits to patients with HCC and type II diabetes undergoing TACE. Metformin may simultaneously address multiple aspects of treatment in these patients.
Efficacy and safety of perioperative application of esketamine on postoperative depression: a meta-analysis of randomized controlled studies
Authors: Yazhou Wen, Mingjie Mao, Ming Jiang, Qiaoqiao Liu, Qian Li, Xuan Wang, Hongmei Yuan, Xian Wang, Shanwu Feng
Journal: International Journal of Surgery (2024)

Background: Postoperative depression has a profound impact on patients’ postoperative rehabilitation and overall quality of life. Preventing postoperative depression is of significant value because conventional antidepressants have a slow onset of action. Esketamine showed prompt and sustained antidepressant efficacy. Nevertheless, the safety and effectiveness of perioperative esketamine in preventing postoperative depression are still unknown. The purpose of this meta-analysis was to assess the safety and effectiveness of perioperative intravenous esketamine in relation to its ability to prevent postoperative depression. Materials and Methods: Randomized controlled trials were searched in the following databases: Web of Science, Cochrane Central Registry of Controlled Trials, PubMed, and Embase. The primary outcome assessed is the postoperative depression scores. Postoperative pain ratings and adverse effects constituted secondary outcomes. Subgroup analyses were carried out on the basis of multiple variables, including the absence or presence of preoperative depression, the mode of esketamine administration, the dosage of esketamine, and the type of anesthesia. Results: A total of 16 studies encompassed 1161 patients who received esketamine intervention, whereas 1106 patients served as controls. Esketamine was efficacious in reducing postoperative depression scores when administered perioperatively, and the esketamine group maintained a lower postoperative depression score than the control group more than four weeks after surgery. Esketamine effectively alleviated postoperative pain scores without increasing the occurrence of postoperative nausea and vomiting, dizziness, drowsiness, nightmares, and dissociation. Conclusion: The administration of esketamine during the perioperative has the potential to decrease postoperative depression and pain scores without increasing the incidence of adverse effects.
The effect of a pre- and post- operative exercise program versus standard care on physical fitness of patients with oesophageal and gastric cancer undergoing neoadjuvant treatment prior to surgery (The PERIOP-OG Trial): a randomized controlled trial
Authors: Lisa Loughney, Jarlath Bolger, Roisin Tully, Jan Sorensen, Marie Bambrick, Paul A. Carroll, Mayilone Arumugasamy, Thomas J. Murphy, Noel McCaffrey, William B. Robb
Journal: International Journal of Surgery (2024)

Introduction: Although the benefits of post-operative rehabilitation in cancer surgery are well established, the role of prehabilitation is less defined. Oesophagogastric cancers present a unique opportunity to study the impact of prehabilitation during the neoadjuvant window, whether with chemotherapy or chemoradiotherapy (NCT) in patients who are frequently nutritionally depleted. This trial examines the impact of a community-based exercise programme on patient fitness during and after the neoadjuvant window. Methods: A pragmatic, randomized controlled multicentre trial was undertaken in three centres. Inclusion criteria were patients aged at least 18 years planned for NCT and esophagectomy or gastrectomy. Participants were randomized 1:1 to an exercise prehabilitation group (EX) or to usual care (UC). The primary endpoint was cardiorespiratory fitness between baseline and pre-surgery time point using the 6-minute walk test (MVT). Secondary endpoints included a hand dynamometer, 10-s sit-to-stand, activity behaviour, body mass index, semi-structured interviews, questionnaires assessing the quality of life, surgical fear, general self-efficacy and mastery. Results: Between March 2019 and December 2020, 71 participants were recruited: EX ( n =36) or UC ( n =35). From baseline to pre-surgery, the difference-in-difference (DID) for EX showed a significant improvement in 6MWT of 50.7 m ( P =0.05) compared to UC [mean (SD): 522.1 m (+/−104.3) to 582.1 m (+/−108) vs. 497.5 m (+/−106.3) to 506.0 m (+/−140.4). There was no statistically significant DID for secondary outcome measures. Conclusions: This community exercise prehabilitation programme significantly improves physical fitness for surgery, is feasible and provides a standardized framework for the prescription of exercise in oesophagogastric cancer patients undergoing NCT.
Comprehensive analysis of cuproptosis-related genes involved in immune infiltration and their use in the diagnosis of hepatic ischemia‒reperfusion injury: an experimental Study
Authors: Xiaopeng Cai, Jingwen Deng, Xiaohu Zhou, Kaiyue Wang, Huiqiang Cai, Yingcai Yan, Jun Jiang, Jia Yang, Jin Gu, Yuan Zhang, Yuan Ding, Qiang Sun, Weilin Wang
Journal: International Journal of Surgery (2024)

Background: Hepatic ischemia reperfusion injury (HIRI) is a common injury not only during liver transplantation but also during major hepatic surgery. HIRI causes severe complications and affects the prognosis and survival of patients. Cuproptosis, a newly identified form of cell death, plays an important role in a variety of illnesses. However, its role in HIRI remains unknown. Materials and methods: The GSE151648 dataset was mined from the Gene Expression Omnibus (GEO) database, and differences were analyzed for intersections. Based on the differentially expressed genes (DEGs), functional annotation, differentially expressed cuproptosis-related genes (DE-CRGs) identification and lasso logistic regression were conducted. Correlation analysis of DE-CRGs and immune infiltration was further conducted, and DE-CRGs were applied to construct an HIRI diagnostic model. The hierarchical clustering method was used to classify the specimens of HIRI, and functional annotation was conducted to verify the accuracy of these DE-CRGs in predicting HIRI progression. The GSE14951 microarray dataset and GSE171539 single-cell sequencing dataset were chosen as validation datasets. At the same time, the significance of DE-CRGs was verified using a mouse model of HIRI with cuproptosis inhibitors and inducers. Finally, a network of transcription-factor-DE-CRGs and miRNA-DE-CRGs was constructed to reveal the regulation mechanisms. And potential drugs for DE-CRGs were predicted using Drug Gene Interaction Database (DGIdb). Results: Overall, 2390 DEGs and 19 DE-CRGs were identified. Through machine learning algorithms, 8 featured DE-CRGs (GNL3, ALAS1, TSC22D2, KLF5, GTF2B, DNTTIP2, SLFN11 and HNRNPU) were screened, and 2 cuproptosis-related subclusters were defined. Based on the 8 DE-CRGs obtained from the HIRI model (AUC=0.97), the nomogram model demonstrated accuracy in predicting HIRI. Eight DE-CRGs were highly expressed in HIRI samples and were negatively related to immune cell infiltration. A higher level of immune infiltration and expression of CRG group B was found in the HIRI population. Differences in cell death and immune regulation were found between the 2 groups. The diagnostic value of the 8 DE-CRGs was confirmed in the validation of two datasets. The identification of 7 DE-CRGs (SLFN11 excluded) by HIRI animal model experiments was also confirmed. Using hTFtarget, miRWalk and DGIDB database, we predicted that 17 transcription factors, 192 miRNAs and 10 drugs might interact with the DE-CRGs. Conclusion: This study shows that cuproptosis may occur in HIRI and is correlated with immune infiltration. Additionally, a cuproptosis-related predictive model was constructed for studying the causes of HIRI and developing targeted treatment options for HIRI.
Comparison of short-term outcomes of robotic versus open Pancreaticoduodenectomy: A Meta-Analysis of randomized controlled trials and Propensity-Score-Matched studies
Authors: Gang Tang, Linyu Zhang, Lingying Xia, Jie Zhang, Rui Chen, Rongxing Zhou
Journal: International Journal of Surgery (2024)

Background: Robotic pancreaticoduodenectomy (RPD) is used more commonly, but this surge is mostly based on observational data. This meta-analysis aimed to compare the short-term outcomes between RPD and open pancreaticoduodenectomy (OPD) using data collected from randomized controlled trials (RCTs) and propensity score-matched (PSM) studies. Materials and methods: We searched PubMed, Cochrane Library, Embase, and Web of Science databases for RCTs and PSM studies comparing RPD and OPD. Risk ratios (RRs) and mean differences (MDs) with 95% confidence intervals (CIs) were calculated. Results: Twenty-four studies, encompassing two RCTs and 22 PSM studies, were included, with a total of 9393 patients (RPD group: 3919 patients; OPD group: 5474 patients). Although RPD was associated with a longer operative time (MD, 61.61 min), patients may benefit from reduced blood loss (MD, -154.05 mL), shorter length of stay (MD, -1.60 d), lower blood transfusion rate (RR, 0.85), and wound infection rate (RR, 0.61). There were no significant differences observed in 30-day readmission (RR, 0.99), 90-day mortality (RR, 0.97), overall morbidity (RR, 0.88), major complications (RR, 1.01), reoperation (RR, 1.08), bile leak (RR, 1.01), chylous leak (RR, 0.98), postoperative pancreatic fistula (RR, 0.97), postpancreatectomy hemorrhage (RR, 1.15), delayed gastric emptying (RR, 0.88), number of harvested lymph nodes (MD, -0.12), and R0 resection (RR, 1.01) between the groups. Conclusions: Although some short-term outcomes were similar between RPD and OPD, RPD exhibited reduced intraoperative blood loss, shorter hospital stays, lower wound infection, and blood transfusion rates. In the future, RPD may become a safe and effective alternative to OPD.