tbuckley/cabot-search huggingface dataset:
Oxygen Vacancy Defect Enhanced NIR‐II Photothermal Performance of BiO<i><sub>x</sub></i>Cl Nanosheets for Combined Phototherapy of Cancer Guided by Multimodal Imaging
Authors: Qianlan Fang, Chengyuan Hong, Zhusheng Liu, Yuning Pan, Jie Lin, Jianjun Zheng, Jingfeng Zhang, Tianxiang Chen, Xuehua Ma, Aiguo Wu
Journal: Advanced Healthcare Materials (2024)

Narrow photo-absorption range and low carrier utilization are significant barriers that restrict the antitumor efficiency of 2D bismuth oxyhalide (BiOX, X = Cl, Br, I) nanosheets (NSs). Introducing oxygen vacancy (OV) defects can expand the absorption range and improve carrier utilization, which are crucial but also challenging. In this study, a series of BiO
The Overdose Crisis among U.S. Adolescents
Authors: Joseph Friedman, Scott E Hadland
Journal: New England Journal of Medicine (2024)

Audio Interview Interview with Joseph Friedman on increases in drug-related mortality among adolescents and approaches to overdose prevention. 10m 23s Download AbstractDrug-overdose deaths among adolescents have increased in recent years. Steps can be taken to equip adolescents with the knowledge and tools they need to keep themselves safe.
Amplified and Specific Staining of Protein Dimerization on Cell Membrane Catalyzed by Responsively Installed DNA Nanomachines for Cancer Diagnosis
Authors: Zhenqiang Wang, Xiyue Xie, Kaifei Jin, Daqing Xia, Jing Zhu, Jixi Zhang
Journal: Advanced Healthcare Materials (2024)

In situ staining of protein dimerization on cell membrane has an important significance in accurate diagnosis during perioperative period, yet facile integration of specific recognition function and local signal conversion/amplification abilities on membrane surface remains a great challenge. Herein, a two-stage catalytic strategy is developed by installing DNA nanomachines and employing. Specifically, dual-aptamer-assisted DNA scaffold perform a "bispecific recognition-then-computing" operation and the output signal initiate a membrane-anchored biocatalysis for self-assembly of DNA catalytic converters, that is, G-quadruplex nanowire/hemin DNAzyme. Then, localized-deposition of chromogenic polydopamine is chemically catalyzed by horseradish peroxidase-mimicking DNAzyme and guided by supramolecular interactions between conjugate rigid plane of G-tetrad and polydopamine oligomer. The catalytic products exhibit nanofiber morphology with a diameter of 80-120 nm and a length of 1-10 µm, and one-to-one localize on DNA scaffold for amplified and specific staining of protein dimers. The bispecific staining leads to a higher (≈3.4-fold) signal intensity than traditional immunohistochemistry, which is beneficial for direct visualization. Moreover, an efficient discrimination ability of the bispecific staining strategy is observed in co-culture model staining. This study provides a novel catalytic method for controlling deposition of chromogens and paves a new avenue to sensitively stain of protein-protein interactions in disease diagnosis.
Vocal-Cord Polyp Causing Airway Obstruction
Authors: Yang Kee Chan, Chia-Ying Li
Journal: New England Journal of Medicine (2024)

A man presented with a 2-week history of progressive, intermittent dyspnea and a 2-year history of hoarseness. Expiratory wheezes were heard over the neck, and partial upper-airway obstruction was seen on imaging (shown in a video).
Randomized Trial of Patient Outreach Approaches to De-implement Outdated Colonoscopy Surveillance Intervals
Authors: Jeffrey K. Lee, Pradeep C. Koripella, Christopher D. Jensen, Sophie A. Merchant, Jeffrey M. Fox, Suyi X. Chang, Christian H. Dang, Fernando S. Velayos, Eshandeep S. Boparai, Nicole S. Evans, Lawrence J. Leung, Jessica M. Badalov, Charles P. Quesenberry, Douglas A. Corley, Theodore R. Levin
Journal: Clinical Gastroenterology and Hepatology (2024)
Safety Analyses of the Phase 3 VISION Trial of [177Lu]Lu-PSMA-617 in Patients with Metastatic Castration-resistant Prostate Cancer
Authors: Kim N. Chi, Andrew J. Armstrong, Bernd J. Krause, Ken Herrmann, Kambiz Rahbar, Johann S. de Bono, Nabil Adra, Rohan Garje, Jeff M. Michalski, Mette M. Kempel, Karim Fizazi, Michael J. Morris, Oliver Sartor, Marcia Brackman, Michelle DeSilvio, Celine Wilke, Geoffrey Holder, Scott T. Tagawa
Journal: European Urology (2024)

[177Lu]Lu-PSMA-617 (177Lu-PSMA-617) plus the standard of care (SoC) significantly improved overall survival and radiographic progression-free survival versus SoC alone in patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer in the VISION trial. We evaluated the safety of additional cycles of 177Lu-PSMA-617 and the impact of longer observation time for patients receiving 177Lu-PSMA-617 plus SoC. VISION was an international, open-label study. Patients were randomised 2:1 to receive 177Lu-PSMA-617 plus SoC or SoC alone. The incidence of treatment-emergent adverse events (TEAEs) was assessed in prespecified subgroups of patients who received ≤4 cycles versus 5–6 cycles of treatment and during each cycle of treatment. The TEAE incidence was also adjusted for treatment exposure to calculate the incidence per 100 patient-treatment years of observation. This analysis was performed for the first occurrence of TEAEs. The any-grade TEAE incidence was similar in cycles 1–4 and cycles 5–6. TEAE frequency was similar across all cycles of 177Lu-PSMA-617 treatment. No additional safety concerns were reported for patients who received >4 cycles. The exposure-adjusted safety analysis revealed that the overall TEAE incidence was similar between arms, but distinct trends for different TEAE types were noted and the incidence of events associated with 177Lu-PSMA-617 remained higher in the 177Lu-PSMA-617 arm. Longer exposure to 177Lu-PSMA-617 plus SoC was not associated with a higher toxicity risk, and the extended time for safety observation could account for the higher TEAE incidence in comparison to SoC alone. The findings support a favourable benefit-risk profile for 6 cycles of 177Lu-PSMA-617 in this setting and the use of up to 6 cycles of 177Lu-PSMA-617 in patients who are clinically benefiting from and tolerating this therapy. For patients with metastatic prostate cancer no longer responding to hormone therapy, an increase in the number of cycles of treatment with a radioactive compound called 177Lu-PSMA-617 from four to six had no additional adverse side effects.
Target genes regulated by CLEC16A intronic region associated with common variable immunodeficiency
Authors: Xubo Huang, Jinxia Huang, Xiumei Li, Jingxian Fan, Desheng Zhou, Hui-Qi Qu, Joseph T. Glessner, Dandan Ji, Qi Jia, Zhiyong Ding, Nan Wang, Wei Wei, Xing Lyu, Mulin Jun Li, Zhe Liu, Wei Liu, Yongjie Wei, Hakon Hakonarson, Qianghua Xia, Jin Li
Journal: Journal of Allergy and Clinical Immunology (2024)
Intelligent nanoreactor coupling tumor microenvironment manipulation and H2O2-dependent photothermal-chemodynamic therapy for accurate treatment of primary and metastatic tumors
Authors: Jie Liu, Tianfeng Yang, Handan Zhang, Lin Weng, Xiuhong Peng, Tao Liu, Cheng Cheng, Yanmin Zhang, Xin Chen
Journal: Bioactive Materials (2024)

Tumor microenvironment (TME), as the "soil" of tumor growth and metastasis, exhibits significant differences from normal physiological conditions. However, how to manipulate the distinctions to achieve the accurate therapy of primary and metastatic tumors is still a challenge. Herein, an innovative nanoreactor (AH@MBTF) is developed to utilize the apparent differences (copper concentration and H2O2 level) between tumor cells and normal cells to eliminate primary tumor based on H2O2-dependent photothermal-chemodynamic therapy and suppress metastatic tumor through copper complexation. This nanoreactor is constructed using functionalized MSN incorporating benzoyl thiourea (BTU), triphenylphosphine (TPP), and folic acid (FA), while being co-loaded with horseradish peroxidase (HRP) and its substrate ABTS. During therapy, the BTU moieties on AH@MBTF could capture excessive copper (highly correlated with tumor metastasis), presenting exceptional anti-metastasis activity. Simultaneously, the complexation between BTU and copper triggers the formation of cuprous ions, which further react with H2O2 to generate cytotoxic hydroxyl radical (•OH), inhibiting tumor growth via chemodynamic therapy. Additionally, the stepwise targeting of FA and TPP guides AH@MBTF to accurately accumulate in tumor mitochondria, containing abnormally high levels of H2O2. As a catalyst, HRP mediates the oxidation reaction between ABTS and H2O2 to yield activated ABTS•+. Upon 808 nm laser irradiation, the activated ABTS•+ performs tumor-specific photothermal therapy, achieving the ablation of primary tumor by raising the tissue temperature. Collectively, this intelligent nanoreactor possesses profound potential in inhibiting tumor progression and metastasis.
Neddylation suppression by a macrophage membrane-coated nanoparticle promotes dual immunomodulatory repair of diabetic wounds
Authors: Ruiyin Zeng, Bin Lv, Ze Lin, Xiangyu Chu, Yuan Xiong, Samuel Knoedler, Faqi Cao, Chuanlu Lin, Lang Chen, Chenyan Yu, Jiewen Liao, Wu Zhou, Guandong Dai, Mohammad-Ali Shahbazi, Bobin Mi, Guohui Liu
Journal: Bioactive Materials (2024)

Oxidative stress, infection, and vasculopathy caused by hyperglycemia are the main barriers for the rapid repair of foot ulcers in patients with diabetes mellitus (DM). In recent times, the discovery of neddylation, a new type of post-translational modification, has been found to regulate various crucial biological processes including cell metabolism and the cell cycle. Nevertheless, its capacity to control the healing of wounds in diabetic patients remains unknown. This study shows that MLN49224, a compound that inhibits neddylation at low concentrations, enhances the healing of diabetic wounds by inhibiting the polarization of M1 macrophages and reducing the secretion of inflammatory factors. Moreover, it concurrently stimulates the growth, movement, and formation of blood vessel endothelial cells, leading to expedited healing of wounds in individuals with diabetes. The drug is loaded into biomimetic macrophage-membrane-coated PLGA nanoparticles (M-NPs/MLN4924). The membrane of macrophages shields nanoparticles from being eliminated in the reticuloendothelial system and counteracts the proinflammatory cytokines to alleviate inflammation in the surrounding area. The extended discharge of MLN4924 from M-NPs/MLN4924 stimulates the growth of endothelial cells and the formation of tubes, along with the polarization of macrophages towards the anti-inflammatory M2 phenotype. By loading M-NPs/MLN4924 into a hydrogel, the final formulation is able to meaningfully repair a diabetic wound, suggesting that M-NPs/MLN4924 is a promising engineered nanoplatform for tissue engineering.
Piezo-enhanced near infrared photocatalytic nanoheterojunction integrated injectable biopolymer hydrogel for anti-osteosarcoma and osteogenesis combination therapy
Authors: Cairong Xiao, Renxian Wang, Rumin Fu, Peng Yu, Jianxun Guo, Guangping Li, Zhengao Wang, Honggang Wang, Jingjun Nie, Weifeng Liu, Jinxia Zhai, Changhao Li, Chunlin Deng, Dafu Chen, Lei Zhou, Chengyun Ning
Journal: Bioactive Materials (2024)

Preventing local tumor recurrence while promoting bone tissue regeneration is an urgent need for osteosarcoma treatment. However, the therapeutic efficacy of traditional photosensitizers is limited, and they lack the ability to regenerate bone. Here, a piezo-photo nanoheterostructure is developed based on ultrasmall bismuth/strontium titanate nanocubes (denoted as Bi/SrTiO3), which achieve piezoelectric field-driven fast charge separation coupling with surface plasmon resonance to efficiently generate reactive oxygen species. These hybrid nanotherapeutics are integrated into injectable biopolymer hydrogels, which exhibit outstanding anticancer effects under the combined irradiation of NIR and ultrasound. In vivo studies using patient-derived xenograft models and tibial osteosarcoma models demonstrate that the hydrogels achieve tumor suppression with efficacy rates of 98.6 % and 67.6 % in the respective models. Furthermore, the hydrogel had good filling and retention capabilities in the bone defect region, which exerted bone repair therapeutic efficacy by polarizing and conveying electrical stimuli to the cells under mild ultrasound radiation. This study provides a comprehensive and clinically feasible strategy for the overall treatment and tissue regeneration of osteosarcoma.
Positive effects of diet-induced microbiome modification on GDM in mice following human faecal transfer
Authors: Sigal Frishman, Meital Nuriel-Ohayon, Sondra Turjeman, Yishay Pinto, Or Yariv, Kinneret Tenenbaum-Gavish, Yoav Peled, Eran Poran, Joseph Pardo, Rony Chen, Efrat Muller, Elhanan Borenstein, Moshe Hod, Yoram Louzoun, Betty Schwartz, Eran Hadar, Maria Carmen Collado, Omry Koren
Journal: Gut (2024)
UEFA Women’s Elite Club Injury Study: a prospective study on 1527 injuries over four consecutive seasons 2018/2019 to 2021/2022 reveals thigh muscle injuries to be most common and ACL injuries most burdensome
Authors: Anna Hallén, Rita Tomás, Jan Ekstrand, Håkan Bengtsson, Elke Van den Steen, Martin Hägglund, Markus Waldén
Journal: British Journal of Sports Medicine (2024)

Injuries in women's football (soccer) have scarcely been investigated, and no study has been conducted in the highest competitive level involving club teams from different countries. Our aim was to investigate the time-loss injury epidemiology and characteristics among women's elite football players over four seasons.
CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury
Authors: Dörte Lodka, Maria Zschummel, Mario Bunse, Anthony Rousselle, Janis Sonnemann, Ralph Kettritz, Uta E Höpken, Adrian Schreiber
Journal: Annals of the Rheumatic Diseases (2024)

Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are life-threatening systemic autoimmune diseases manifesting in the kidneys as necrotizing crescentic glomerulonephritis (NCGN). ANCA antigens are myeloperoxidase (MPO) or proteinase 3. Current treatments include steroids, cytotoxic drugs and B cell-depleting antibodies. The use of chimeric antigen receptor (CAR) T cells in autoimmune diseases is a promising new therapeutic approach. We tested the hypothesis that CAR T cells targeting CD19 deplete B cells, including MPO-ANCA-producing B cells, thereby protecting from ANCA-induced NCGN.
Unveiling 8 years of duodenoscope contamination: insights from a retrospective analysis in a large tertiary care hospital
Authors: Koen van der Ploeg, Cynthia P. Haanappel, Anne F. Voor in 't holt, Woutrinus de Groot, Adriana J. C. Bulkmans, Nicole S. Erler, Bibi C. G. C. Mason-Slingerland, Juliëtte A. Severin, Margreet C. Vos, Marco J. Bruno
Journal: Gut (2024)

Objective Contaminated duodenoscopes caused several hospital outbreaks. Despite efforts to reduce contamination rates, 15% of patient-ready duodenoscopes are still contaminated with gastrointestinal microorganisms. This study aimed to provide an overview of duodenoscope contamination over time, identify risk factors and study the effects of implemented interventions. Design Duodenoscope culture sets between March 2015 and June 2022 at a Dutch tertiary care centre were analysed. Contamination was defined as (1) the presence of microorganisms of oral or gastrointestinal origin (MGO) or (2) any other microorganism with ≥20 colony-forming units/20 mL (AM20). A logistic mixed effects model was used to identify risk factors and assess the effect of interventions, such as using duodenoscopes with disposable caps, replacing automated endoscope reprocessors (AER) and conducting audits in the endoscopy department. Results A total of 404 culture sets were analysed. The yearly contamination rate with MGO showed great variation, ranging from 14.3% to 47.5%. Contamination with AM20 increased up to 94.7% by 2022. For both MGO and AM20, the biopsy and suction channels were the most frequently contaminated duodenoscope components. The studied interventions, including audits, AER replacement and implementation of duodenoscopes with disposable caps, did not show a clear association with contamination rates. Conclusion Duodenoscope contamination remains a significant problem, with high contamination rates despite several interventions. Reprocessing the biopsy and suction channels is especially challenging. Changes in the design of reusable duodenoscopes, such as enabling sterilisation or easily replaceable channels, are necessary to facilitate effective duodenoscope reprocessing and to eliminate the risk of duodenoscope-associated infections.
Reply: Cognitive behavioural therapy sessions approach ineffective for anxiety and depression in COPD: is the door closed for good?
Authors: Stephanie J.C. Taylor, Ratna Sohanpal, Liz Steed, Karen Marshall, Moira J. Kelly, Martin Underwood, Patrick White, Hilary Pinnock
Journal: European Respiratory Journal (2024)

<h3>Tweetable abstract</h3> <b>Our trial does not support using a CBA approach to alleviate mild/moderate anxiety and/or depression in people with moderate/severe COPD. New approaches are needed to relieve the substantial mental health burden in these patients with complex needs.</b>https://bit.ly/3TkkDt3
Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types
Authors: Nicolas Tchitchek, Marie Binvignat, Alexandra Roux, Fabien Pitoiset, Johanna Dubois, Gwendolyn Marguerit, David Saadoun, Patrice Cacoub, Jérémie Sellam, Francis Berenbaum, Agnès Hartemann, Chloé Amouyal, Roberta Lorenzon, Encarnita Mariotti-Ferrandiz, Michelle Rosenzwajg, David Klatzmann
Journal: Annals of the Rheumatic Diseases (2024)

Based on genetic associations, McGonagle and McDermott suggested a classification of autoimmune and autoinflammatory diseases as a continuum ranging from purely autoimmune to purely autoinflammatory diseases and comprising diseases with both components. We used deep immunophenotyping to identify immune cell populations and molecular targets characterising this continuum.
Development of anti-PEG IgG/IgM/IgE ELISA assays for profiling anti-PEG immunoglobulin response in PEG-sensitized individuals and patients with alpha-gal allergy
Authors: Zhongbo Li, Alice Ma, Ian Miller, Rachel Starnes, Anne Talkington, Cosby A. Stone, Elizabeth J. Phillips, Shailesh K. Choudhary, Scott P. Commins, Samuel K. Lai
Journal: Journal of Controlled Release (2024)
Body composition and respiratory outcomes in children: a population-based prospective cohort study
Authors: Tong Wu, Susana Santos, Hugo G Quezada‐Pinedo, Meike W. Vernooij, Vincent W.V. Jaddoe, Stefan Klein, Liesbeth Duijts, Edwin H.G. Oei
Journal: Thorax (2024)

Background Body composition might influence lung function and asthma in children, but its longitudinal relations are unclear. We aimed to identify critical periods for body composition changes during childhood and adolescence in relation to respiratory outcomes in adolescents. Methods In a population-based prospective cohort study, we measured body mass index, fat mass index (FMI), lean mass index (LMI) and the ratio of android fat mass divided by gynoid fat mass (A/G ratio) by dual-energy X-ray absorptiometry at 6, 10 and 13 years. At 13 years, lung function was measured by spirometry, and current asthma was assessed by questionnaire. Results Most prominently and consistently, higher FMI and A/G ratio at age 13 years were associated with lower forced expiratory volume in 1 s (FEV 1 )/forced vital capacity (FVC) and forced expiratory flow after exhaling 75% of FVC (FEF 75 ) (range Z-score difference −0.13 (95% CI −0.16 to –0.10) to −0.08 (95% CI −0.11 to –0.05) per SD score increase), and higher LMI at all ages was associated with higher FEF 75 (range Z-score difference 0.05 (95% CI 0.01 to 0.08) to 0.09 (95% CI 0.06 to 0.13)). Between the ages of 6 and 13 years, normal to high FMI and A/G ratio were associated with lower FEV 1 /FVC and FEF 75 (range Z-score difference −0.20 (95% CI −0.30 to –0.10) to −0.17 (95% CI −0.28 to –0.06)) and high to high LMI with higher FEF 75 (range Z-score difference0.32 (95% CI 0.23 to 0.41)). Body composition changes were not associated with asthma. Conclusion Adolescents with higher total and abdominal fat indices may have impaired lung function, while those with a higher lean mass during childhood and adolescence may have better small airway function. Public health measures should focus on a healthy body composition in adolescents to minimise respiratory morbidity.
Prognostic model to predict the incidence of radiographic knee osteoarthritis
Authors: Rocío Paz-González, Vanesa Balboa-Barreiro, Lucia Lourido, Valentina Calamia, Patricia Fernandez-Puente, Natividad Oreiro, Cristina Ruiz-Romero, Francisco J Blanco
Journal: Annals of the Rheumatic Diseases (2024)

Objective Early diagnosis of knee osteoarthritis (KOA) in asymptomatic stages is essential for the timely management of patients using preventative strategies. We develop and validate a prognostic model useful for predicting the incidence of radiographic KOA (rKOA) in non-radiographic osteoarthritic subjects and stratify individuals at high risk of developing the disease. Methods Subjects without radiographic signs of KOA according to the Kellgren and Lawrence (KL) classification scale (KL=0 in both knees) were enrolled in the OA initiative (OAI) cohort and the Prospective Cohort of A Coruña (PROCOAC). Prognostic models were developed to predict rKOA incidence during a 96-month follow-up period among OAI participants based on clinical variables and serum levels of the candidate protein biomarkers APOA1, APOA4, ZA2G and A2AP. The predictive capability of the biomarkers was assessed based on area under the curve (AUC), and internal validation was performed to correct for overfitting. A nomogram was plotted based on the regression parameters. Model performance was externally validated in the PROCOAC. Results 282 participants from the OAI were included in the development dataset. The model built with demographic, anthropometric and clinical data (age, sex, body mass index and WOMAC pain score) showed an AUC=0.702 for predicting rKOA incidence during the follow-up. The inclusion of ZA2G, A2AP and APOA1 data significantly improved the model’s sensitivity and predictive performance (AUC=0.831). The simplest model, including only clinical covariates and ZA2G and A2AP serum levels, achieved an AUC=0.826. Both models were internally cross-validated. Predictive performance was externally validated in an independent dataset of 100 individuals from the PROCOAC (AUC=0.713). Conclusion A novel prognostic model based on common clinical variables and protein biomarkers was developed and externally validated to predict rKOA incidence over a 96-month period in individuals without any radiographic signs of disease. The resulting nomogram is a useful tool for stratifying high-risk populations and could potentially lead to personalised medicine strategies for treating OA.