tbuckley/cabot-search huggingface dataset:
Perinatal Flavored E-cigarette Exposure and the Critical Role of Innate Lymphoid type II Cells in Transgenerational Asthma Transmission
Authors: Gourav Chandan, Ying Wang, Noushin Lotfi, Jie Liu, Sabrina Madrigal, Celia Yu, Dylan Hatai, Reiko Sakurai, Leela Afrose, Kei Sakano, Yoshihiro Sakano, Mohammad Kazemi, Omid Akbari, Virender Rehan
Journal: Journal of Allergy and Clinical Immunology (2025)
High Percentage of Peripheral Lymph Node Addressin-Expressing Vessels and CD163+/CD68+ Macrophage Ratio Observed in Nasal Polyps Formed in Allergic Fungal Rhinosinusitis
Authors: Eiichi Kato, Masafumi Sakashita, Yoshinori Matsuwaki, Shigeharu Fujieda
Journal: Journal of Allergy and Clinical Immunology (2025)
Crosstalk of Innate and Adaptive Immune Responses in Laundry Detergents-Induced Antigen-Specific Eosinophilic Airway Inflammation
Authors: Naoko Nagano, Kyoko Saito, Keisuke Orimo, Hiromichi Yamamoto, Hisataka Nakazaki, Satoshi Fujita, Yuka Hayashi, Masato Tamari, Kenichiro Motomura, Masashi Ikutani, Susumu Nakae, Hirohisa Saito, Hideaki Morita, Kenji Matsumoto
Journal: Journal of Allergy and Clinical Immunology (2025)
Azithromycin Treatment During Early-Life Severe RSV Bronchiolitis: Impact on The Upper Airway Microbiome and Subsequent Recurrent Wheezing
Authors: Avraham Beigelman, Hanshu Yuan, Liu Zhongmao, Leonard Bacharier, Charles Goss, Jinli Wang, Mythili Srinivasan, Jonathan Boomer, Sarah Bram, Timothy Casper, Andrea Coverstone, Watcharoot Kanchongkittiphon, Cadence Kuklinski, Gregory Storch, Kenneth Schechtman, Mario Castro, Yanjiao Zhou
Journal: Journal of Allergy and Clinical Immunology (2025)
Resurgence of Respiratory Syncytial Virus Following COVID-19 Pandemic Measures: A Study of Antibody Dynamics in Young Children
Authors: Joshua Kennedy, Collette Tilly, Justin Chin, Rachel Frenner, Rachel Frenner, Bobby Boyanton, Ashton Ingold, Susanna Hartzell, Dana Frederick
Journal: Journal of Allergy and Clinical Immunology (2025)
Soil nitrogen enrichment of grasslands increases pollen allergenicity: a cross-sectional paired comparison study
Authors: Robin Daelemans, Paulien Verscheure, Thomas Rombouts, Sien Keysers, Lieve Coorevits, Glynis Frans, Laura Van Gerven, Tobias Ceulemans, Nicolas Bruffaerts, Olivier Honnay, Rik Schrijvers, Raf Aerts
Journal: Journal of Allergy and Clinical Immunology (2025)
First Aerobiological Documentation of Ragweed (Ambrosia spp.) Pollen in Ecuador: Implications for Public Health and Environmental Management
Authors: Ivan Cherrez Ojeda, Ana Ochoa-Brito, Andres Espinoza Maticurena, Gabriela Rodas-Valero, Daniela Hidalgo Molina, Karen Bohorquez Maldonado, Karla Robles-velasco, Evelyn García Moreira, Vanja Mosquera Chavez, Jorge Calderon Salazar, Ivan Tinoco Moran
Journal: Journal of Allergy and Clinical Immunology (2025)
Avapritinib improves disease control and quality of life in patients with indolent systemic mastocytosis: First results of the real-world evidence study AVATAR
Authors: Polina Pyatilova, Philipp le Coutre, Leonie Herzog, Melba Muñoz, Nicole Nojarov, Pascale Salameh, Sebastian Schröder, Frank Siebenhaar
Journal: Journal of Allergy and Clinical Immunology (2025)
Baseline Characteristics Associated With Multicomponent Clinical Remission Following Dupilumab Treatment In Patients With Moderate-To-Severe Asthma
Authors: Giorgio Canonica, Luis Pérez de Llano, Ian Pavord, Simon Couillard, Celeste Porsbjerg, Guy Brusselle, Mario Castro, Anju Peters, Arnaud Bourdin, Arman Altincatal, Jason Kwah, Olivier Ledanois
Journal: Journal of Allergy and Clinical Immunology (2025)
Allergic Phenotype Differences Between Peanut and Cashew Allergic Individuals
Authors: Madhavi Karthik, Ella Parsons, Shu Cao, Kristine Martinez, Laurie Kost, Diane Dunham, Olivia Raeber, Margaret Woch, Sayantani Sindher, R. Sharon Chinthrajah
Journal: Journal of Allergy and Clinical Immunology (2025)
Gut Dysbiosis Highlights the Role of Methionine, Serotonin, and PPAR-γ Pathways in Atopic Dermatitis and Food Allergy Phenotypes
Authors: Narissara Suratannon, Pantipa Chatchatee, Massalin Nakpaichit, Wanwipa Vongsangnak, Preecha Patumcharoenpol, Sittiruk Roytrakul, Amornthep Kingkaw, Wanlapa Weerapakorn Weerapakorn, Sunee Nitisinprasert Sunee Nitisinprasert, Anchalee Senavonge
Journal: Journal of Allergy and Clinical Immunology (2025)
Mepolizumab Reduces Systemic Corticosteroid (SCS)-Related Toxicities Compared to Chronic SCS Use in Patients with EGPA
Authors: Thanai Pongdee, Arijita Deb, Jared Silver, Francois Laliberte, Chi Gao, Annalise Hilts, Kaixin Zhang, Daisy Liu, Amy Edgecomb
Journal: Journal of Allergy and Clinical Immunology (2025)
Characterizing the Molecular and Functional Consequences of Dominant-Negative IFNGR1 Mutations in Mendelian Susceptibility to Mycobacterial Disease
Authors: Samantha Chan, Mai Margetts, Longfei Wang, Jack Godsell, Josh Chatelier, Belinda Liu, Charlotte Slade, Andrew Brett, Kasha Singh, Vanessa Bryant, Lauren Howson
Journal: Journal of Allergy and Clinical Immunology (2025)
Cutaneous Blood Flow is a Potential Objective Biomarker of Food Allergy Reactivity During Oral Food Challenges
Authors: Elizabeth Carr, Brittany Bindon, Zoe Brown, Theresa Dunham, Megan Elios, Brittany Graff, Steve Handoyo, So Lim Kim, Sharmilee Nyenhuis, Ruchi Singla, Christina Ciaccio
Journal: Journal of Allergy and Clinical Immunology (2025)
Intra-nasal self-administration of an innate immune activator, AD17002, effective in moderate to severe eosinophilic asthmatics: a pilot proof-of-concept trial
Authors: MEI-CHUAN Chen, Chih-Ming Weng, YU-SHEN HSU, HAN-PIN KUO, Meng-Jung Lee, Chun-Liang Chou
Journal: Journal of Allergy and Clinical Immunology (2025)
Inducible IL-33 expression from the basal epithelium enhances epicutaneous antigen sensitization and anaphylaxis
Authors: James Bonellos, Mia Masuda, Piper Heiligenstein, Koji Iijima, Adelyn Dao, Min-jhen Jheng, Jared Brooksby, Jessica Gibson, Benjamin Wright, Alfred Doyle
Journal: Journal of Allergy and Clinical Immunology (2025)
Wildfire Smoke Exposure During COVID-19 Vaccination is Correlated with Reduced Humoral Immunity After Six Months
Authors: Emma Keller, Gursharan Kaur Sanghar, Melissa Teuber, Resmi Ravindran, Sean Raffuse, Pedro Hernandez, Angela Linderholm, Gabrielle Echt, Lisa Franzi, Kaelyn Tuermer-Lee, Maya Juarez, Timothy Albertson, Imran Khan, Angela Haczku
Journal: Journal of Allergy and Clinical Immunology (2025)
PAI-1 genotype and regulation of airway PAI-1 in vivo: relationships with patterns of airway gene expression during illness
Authors: Madeline Schutt, Samantha Gadd, James Senter, Leonardo Barrera, Seong Cho, Jacqueline Pongracic, Andrew Liu, Rebecca Gruchalla, Carolyn Kercsmar, Gurjit Khurana Hershey, Edward Zoratti, Christine Johnson, Stephen Teach, Meyer Kattan, Leonard Bacharier, George O'Connor, James Gern, Cynthia Visness, Amaziah Coleman, Peter Gergen, Patrice Becker, Daniel Jackson, Matthew Altman, Rajesh Kumar
Journal: Journal of Allergy and Clinical Immunology (2025)
Genetic Risk Scores of Th1, Th2, and Th17-related loci are predictive of response to omalizumab, mepolizumab, and dupilumab
Authors: Ayobami Akenroye, Chengyue Zhang, Tanawin Nopsopon, Jessica Lasky-Su, Sean Kalra, Scott Weiss, Matthew Moll
Journal: Journal of Allergy and Clinical Immunology (2025)
Classification of Cross-Reactive Monoclonal IgE to α-Hairpinin Allergens in Tomato, Peanut, and Walnut
Authors: Taylor Cosey, Isabelle Lytle, Gage Leighton, Alexander Foo, Scott Gabel, Robert Petrovich, Jian Zhang, Paige Creeks, Stokes Peebles, Lars Pedersen, Derek Croote, Scott Smith, Geoffrey Mueller
Journal: Journal of Allergy and Clinical Immunology (2025)
B Cells are Required for the Asthma-Protective Activity of Amish Farm Dust Extracts
Authors: Sydney VanLinden, Avery DeVries, Peace Ezeh, Ashley Michael, Oksana Pivniouk, Dayna Anderson, Mark Holbreich, Vadim Pivniouk, Donata Vercelli
Journal: Journal of Allergy and Clinical Immunology (2025)
Elevated Fucosylation and the Role of Fut1 in Asthma: A Key Contributor to Abnormal Glycosylation in Airway Epithelial Cells
Authors: Wenjing Gu, Zhifeng Chen, Rongrong Yan, Shuang Yang, Chuangli Hao, Peisong Gao
Journal: Journal of Allergy and Clinical Immunology (2025)
EVALUATION OF TRANSITION OF CARE FROM PEDIATRIC TO ADULT IMMUNOLOGY SERVICES AT A NATIONAL REFERRAL CENTER: OUR EXPERIENCE
Authors: Maria Luisa Quiñones Obando, Patricia Andrea Quijada-Morales, María Mercedes Diaz Luna, Gabriela Zambrano Ibarra, Rodnel Enrique Poli Pérez, Alicia Domínguez Estirado, Estela Menendez Rivero, Raúl Francesco Altuve Giannini, María Alejandra Mejía González, Elena Seoane Reula
Journal: Journal of Allergy and Clinical Immunology (2025)
Reduction in Asthma Exacerbations Following Initiation of Benralizumab Among Medicare Beneficiaries: Results from the ZEPHYR-5 Study
Authors: Muhammad Adrish, Jessica DeMartino, Donna Carstens, Mandy Jackson, Jill Schinkel, Kathleen Wilson, Joseph Tkacz
Journal: Journal of Allergy and Clinical Immunology (2025)
Low Adherence to Current Biologic Therapies in Asthma: Insights From a Retrospective Cohort Analysis of Claims Data
Authors: Justin Kwiatek, Rafael Alfonso-Cristancho, Jiaxuan Wang, Peter Howarth, Urvee Karsanji, Jeremiah Hwee, Fan Zhao, Gerald Smith, Riley Geason, Arijita Deb
Journal: Journal of Allergy and Clinical Immunology (2025)
Real-world Treatment Patterns Amongst Patients with Chronic Spontaneous Urticaria Initiating Advanced Therapies
Authors: Jonathan Bernstein, Ryan Thomas, Chien-Chia Chuang, Chao Chen, Min Yang, Bruno Martins, Abigail Zion, Sonya Cyr, Tayler Gonzalez, Adam Friedman
Journal: Journal of Allergy and Clinical Immunology (2025)
Fecal Phospholipids Are Associated With Atopic Respiratory Phenotypes And Inflammatory Nasal Transcriptome In Urban Children With Asthma
Authors: Mustafa Ozcam, Kathryn McCauley, Din Lin, Holly Steininger, Anthony Chang, Danny Li, Dirk Tolson, Scott Presnell, Claire Schachtschneider, Cynthia Visness, Agustin Calatroni, Lisa Wheatley, Carolyn Baloh, Srinath Sanda, Stacie Jones, Katherine RiveraSpoljaric, Meyer Kattan, George O'Connor, Robert Wood, Leonard Bacharier, Daniel Jackson, Matthew Altman, James Gern, Susan Lynch
Journal: Journal of Allergy and Clinical Immunology (2025)
Effect Of Treatment With Benralizumab Or Mepolizumab On The Whole Blood Transcriptomic Profile In Eosinophilic Granulomatosis With Polyangiitis
Authors: Eva Rodríguez-Suárez, Zhi Liu, Mathias Cardner, Lisa Öberg, Michael Wechsler, Peter Merkel, Benjamin Terrier, David Jayne, Florence Roufosse, Nancy Agmon-Levin, Lena Börjesson Sjö, Sofia Necander, Maria Jison, Daniel Muthas, Chris Chamberlain, Adam Platt, Christopher McCrae
Journal: Journal of Allergy and Clinical Immunology (2025)
Consistent Efficacy and Safety Among Children, Adolescents, and Adults with Allergic Rhinitis/Rhinoconjunctivitis Receiving 12 SQ-HDM House Dust Mite Sublingual Immunotherapy Tablet
Authors: Hendrik Nolte, David Bernstein, Majken Hougaard Foss-Skiftesvik, Remi Gagnon, Tomokazu Matsuoka, Ryuji Azuma, Oliver Pfaar, Antje Schuster
Journal: Journal of Allergy and Clinical Immunology (2025)
Responses to Avapritinib in Patients Without Detectable KIT Mutations by ddPCR in Peripheral Blood Highlight Diagnostic Challenges and Opportunities in Indolent Systemic Mastocytosis
Authors: Thanai Pongdee, Pankit Vachhani, Tsewang Tashi, Ivan Alvarez-Twose, Patrizia Bonadonna, Deepti Radia, Hanneke Oude Elberink, Jason Gotlib, Sonia Cerquozzi, Vito Sabato, Ingunn Dybedal, Massimo Triggiani, Cristina Bulai Livideanu, Karin Hartmann, Stephen Oh, Prithviraj Bose, Ruchi Desai, Philipe Schafhausen, Marcus Maurer, Frank Siebenhaar, Tracy George, Sigurd Broesby-Olsen, Guang Yang, Rachel Erlich, Hui-Min Lin, Mark Rosenzweig, Benjamin Lampson, Cem Akin
Journal: Journal of Allergy and Clinical Immunology (2025)
Two-Year Efficacy and Safety of Benralizumab for the Treatment of Eosinophilic Granulomatosis with Polyangiitis
Authors: Michael Wechsler, Parameswaran Nair, Nader Khalidi, Benjamin Terrier, Bernhard Hellmich, Arnaud Bourdin, David Jayne, David Jackson, Florence Roufosse, Christian Pagnoux, Ulrich Specks, Lena Börjesson Sjö, Calvin Ho, Maria Jison, Christopher McCrae, Sofia Necander, Eva Rodríguez-Suárez, Anat Shavit, Claire Walton, Peter Merkel
Journal: Journal of Allergy and Clinical Immunology (2025)
Effects of Type 3 and Neutrophilic Inflammation on Type 2 Chronic Rhinosinusitis with Nasal Polyps
Authors: Aiko Oka, Aiko Klingler, Masanori Kidoguchi, Julie Poposki, Lydia Suh, Junqin Bai, Whitney Stevens, Anju Peters, Leslie Grammer, Kevin Welch, Stephanie Smith, David Conley, Brian Schwartz, Robert Schleimer, Robert Kern, Bruce Tan, Shigeharu Fujieda, Mitsuhiro Okano, Atsushi Kato
Journal: Journal of Allergy and Clinical Immunology (2025)
Initial results from BEACON, a phase 1b/2a dose escalation study of the anti-c-Kit briquilimab antibody in adults with chronic spontaneous urticaria (CSU)
Authors: Thomas Casale, Edwin Tucker, Jinwei Yuan, Daniel Adelman, David Ku, Annette Marcantonio, Patricia Carlos, Sophia Majeed, Wendy Pang, Marcus Maurer, Martin Metz
Journal: Journal of Allergy and Clinical Immunology (2025)
Development of Pan-H5 Vaccines Against Avian Influenza Developed Using Computational Biology to Mitigate Future Pandemics
Authors: Ronald Moss, Joanne Del Rosario, Sneha Vishwanath, Pauline Van Diemen, Sneha Sujit, Sruthika Ashokan, Paul Tonks, George Carnell, Benedikt Asbach, Nigel Temperton, David Moss, Ralf Wagner, Rebecca Kinsley, James Joe, None helen everett, Jonathan Heeney
Journal: Journal of Allergy and Clinical Immunology (2025)
Efficacy And Safety Of Tezepelumab In Adults With Severe Chronic Rhinosinusitis With Nasal Polyps: Results From The Phase 3 WAYPOINT Study
Authors: Joseph Han, Brian Lipworth, Martin Desrosiers, Claire Hopkins, Stella Lee, Joaquim Mullol, Oliver Pfaar, Ting Li, Claudia Chen, Gun Almqvist, Mary Kay Margolis, Julie Mclaren, Shankar Jagadeesh, Jamie MacKay, Vaishali Mankad, Lila Bahadori, Sandhia Ponnarambil
Journal: Journal of Allergy and Clinical Immunology (2025)
Skin tape-strips identify specific immune, epidermal barrier, and asthma-associated biomarker changes in children, adolescent, and adult patients with allergic asthma
Authors: Daniel Liu, Ester Del Duca, Megan Lau, Benjamin Shwartzman, Madeline Kim, Jonathan Bar, Ioana Agache, Emma Guttman-Yassky
Journal: Journal of Allergy and Clinical Immunology (2025)
HAE Attack Rates in Pediatric Patients 2 to &lt;12 Years of Age with Prophylactic Berotralstat: Results from Interim Analysis of APeX-P
Authors: Jolanta Bernatoniene, Melisande Bourgoin-Heck, William Yang, Scott Brantley, Michael DeSpirito, Douglas Johnston, Aimee Liu, Daniel Long, Mauro Cancian, Emel Aygoren-Pursun
Journal: Journal of Allergy and Clinical Immunology (2025)
Observed Incidence of Anaphylaxis and Serum Sickness in Patients Receiving Omalizumab in A Canadian Tertiary Allergy/Asthma Clinic : An Update
Authors: Stephanie Santucci, William Yang, Andrew Comiskey, Timothy Olynych, Duazylle Torres, Hazelyn Torres, Suzanne Kelly, Rachel Friedrich
Journal: Journal of Allergy and Clinical Immunology (2025)
Targeting ADAR1 with a small molecule for the treatment of prostate cancer
Authors: Xiao Wang, Jiaxing Li, Yasheng Zhu, Hongtao Shen, Jiayu Ding, Ting Zeng, Wenjian Min, Shun-Qing Liang, Lei Huang, Zhongrui Shi, Hao Shen, Fei Huang, Kai Yuan, Wenbin Kuang, Minghui Ji, Chengliang Sun, Yi Hou, Liping Wang, Weijiao Chen, Yuzhang Jiang, Haiping Hao, Yibei Xiao, Peng Yang
Journal: Nature Cancer (2025)
Development and Validation of a Cephalosporin Allergy Clinical Decision Rule – CEPH-FAST
Authors: Jason Trubiano, Elise Mitri, Fionnuala Cox, Richard Sullivan, Cosby Stone, Grace Koo, Elizabeth Phillips, Suran Fernando, Moneerah AlGassim, Sara Vogrin, Joseph De Luca, Morgan Rose, Kyra Chua, Natasha Holmes, Ana Maria Copaescu
Journal: Journal of Allergy and Clinical Immunology (2025)
Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups
Authors: Thomas J Hoffmann, Rebecca E Graff, Ravi K Madduri, Alex A Rodriguez, Clinton L Cario, Karen Feng, Yu Jiang, Anqi Wang, Robert J Klein, Brandon L Pierce, Scott Eggener, Lin Tong, William Blot, Jirong Long, Louisa B Goss, Burcu F Darst, Timothy Rebbeck, Joseph Lachance, Caroline Andrews, Akindele O Adebiyi, Ben Adusei, Oseremen I Aisuodionoe-Shadrach, Pedro W Fernandez, Mohamed Jalloh, Rohini Janivara, Wenlong C Chen, James E Mensah, Ilir Agalliu, Sonja I Berndt, John P Shelley, Kerry Schaffer, Mitchell J Machiela, Neal D Freedman, Wen-Yi Huang, Shengchao A Li, Phyllis J Goodman, Cathee Till, Ian Thompson, Hans Lilja, Dilrini K Ranatunga, Joseph Presti, Stephen K Van Den Eeden, Stephen J Chanock, Jonathan D Mosley, David V Conti, Christopher A Haiman, Amy C Justice, Linda Kachuri, John S Witte
Journal: Nature Genetics (2025)
Development Of A Novel Detection Method For Allergen-specific IgE Antibodies Which Cross-link IgE Receptors Using Sera From Patients With Type-I Allergy
Authors: Yuki Koga, Tomoharu Yokooji, Ryohei Ogino, Takanori Taogoshi, Daiki Matsubara, Kaori Ishii, Yuko Chinuki, Eishin Morita, Shunsuke Takahagi, Akio Tanaka, Hiroaki Matsuo
Journal: Journal of Allergy and Clinical Immunology (2025)
Long-Term Assessment of Antibody Profiles after the IMPACT Peanut Oral Immunotherapy Trial: Findings from the IMPACT-PLuS Follow-up
Authors: Yamini Virkud, Jennifer Dantzer, Amanda Cox, Anusha Penumarti, Janelle Kesselring, Kim Mudd, Sayantani Sindher, Amy Scurlock, Deanna Hamilton, Nicholas Anania, Jana Ayash, Keilaa-demi DeLaCruz, Safia Nawaz, Laurie Kost, R. Sharon Chinthrajah, Edwin Kim, Hugh Sampson, Stacie Jones, Robert Wood, Michael Kulis
Journal: Journal of Allergy and Clinical Immunology (2025)
Persistent Reactivity: Oral Food Challenge Outcomes in Food Protein Induced Enterocolitis Syndrome (FPIES)
Authors: Vivian Szeto, Anahita Dehmoobadsharifabadi, Jason Chen, Alana Baic, Alvin Gutierrez, Susan Waserman, Jenny Garkaby, Bradley Jackson, Rae Brager
Journal: Journal of Allergy and Clinical Immunology (2025)
Sexual Dimorphism in Differential Gene Expression in Infants at High Risk for Peanut Allergy
Authors: Killian Buechler, Elizabeth Lippner, Samantha Gadd, Abigail Lang, Matthew Schipma, Hannah Aalemansour, John Kane, Hanli Fan, Demirkan Gursel, Patrick McMullen, Sergejs Berdnikovs, Rajesh Kumar
Journal: Journal of Allergy and Clinical Immunology (2025)
Successful T cell immune reconstitution following Cultured Thymus Tissue Implantation (CTTI) in children with congenital athymia who received Hematopoietic Stem Cell Transplant (HSCT)
Authors: Benjamin Stewart-Bates, Elizabeth McCarthy, Paul Martin, Samantha Cresoe-ortiz, Guglielmo Venturi, John Sleasman
Journal: Journal of Allergy and Clinical Immunology (2025)
The Gastrointestinal Tract-Restricted Helminth H. polygyrus bakeri Protects Against SARS-CoV-2-Induced Lung Disease in Mice
Authors: Courtney Karl, Pritesh Desai, Meizi Liu, Samantha Mackin, Zhenlu Chong, Jinsheng Yu, Larissa Thackray, Michael Diamond
Journal: Journal of Allergy and Clinical Immunology (2025)
Impact Of Race on Baseline Asthma Severity and Response to Biologic Therapy in the First 12 Months Post Biologic Initiation
Authors: Monica Littlejohn, Autumn Zuckerman, Katie Cruchelow, Leena Choi, Nicolas Gargurevich, Robert Lubwama, Richard Stanford, Caresse Campbell, Manny Nunez, Wei-Han Cheng, Natalia Petruski-Ivleva
Journal: Journal of Allergy and Clinical Immunology (2025)
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
Authors: Shouya Feng, Matthew C Wierzbowski, Katja Hrovat-Schaale, Andreas Dumortier, Yaoyuan Zhang, Maria Zyulina, Paul J Baker, Thomas Reygaerts, Annemarie Steiner, Dominic De Nardo, Dhanya Lakshmi Narayanan, Florian Milhavet, Alberto Pinzon-Charry, Juan Ignacio Arostegui, Raju P Khubchandani, Matthias Geyer, Guilaine Boursier, Seth L Masters
Journal: Nature Immunology (2025)

The NLRP3 inflammasome is a multiprotein complex that mediates caspase-1 activation and the release of proinflammatory cytokines, including interleukin (IL)-1β and IL-18. Gain-of-function variants in the gene encoding NLRP3 (also called cryopyrin) lead to constitutive inflammasome activation and excessive IL-1β production in cryopyrin-associated periodic syndromes (CAPS). Here we present functional screening and automated analysis of 534 NLRP3 variants from the international INFEVERS registry and the ClinVar database. This resource captures the effect of NLRP3 variants on ASC speck formation spontaneously, at low temperature, after inflammasome stimulation and with the specific NLRP3 inhibitor MCC950. Most notably, our analysis facilitated the updated classification of NLRP3 variants in INFEVERS. Structural analysis suggested multiple mechanisms by which CAPS variants activate NLRP3, including enhanced ATP binding, stabilizing the active NLRP3 conformation, destabilizing the inactive NLRP3 complex and promoting oligomerization of the pyrin domain. Furthermore, we identified pathogenic variants that can hypersensitize the activation of NLRP3 in response to nigericin and cold temperature exposure. We also found that most CAPS-related NLRP3 variants can be inhibited by MCC950; however, NLRP3 variants with changes to proline affecting helices near the inhibitor binding site are resistant to MCC950, as are variants in the pyrin domain, which likely trigger activation directly with the pyrin domain of ASC. Our findings could help stratify the CAPS population for NLRP3 inhibitor clinical trials and our automated methodologies can be implemented for molecules with a different mechanism of activation and in laboratories worldwide that are interested in adding new functionally validated NLRP3 variants to the resource. Overall, our study provides improved diagnosis for patients with CAPS, mechanistic insight into the activation of NLRP3 and stratification of patients for the future application of targeted therapeutics.
Peanut-Allergic Subjects Tolerate Higher Doses of Autoclaved Peanuts Compared to Blanched During Oral Food Challenges
Authors: Casey Cohen, Diana Toscano Rivero, Adnan Al Ali, Abdulaziz Alrafiaah, Liane Beaudette, Duncan Lejtenyi, Hana Chazbey, Bertrand Jean-Claude, Moshe Ben-Shoshan, Bruce Mazer
Journal: Journal of Allergy and Clinical Immunology (2025)
Enhancing Peanut and Tree Nut Allergy Diagnostics Using Linear and Conformational IgE Epitopes of Vicilin-Buried Peptides
Authors: Lauren Swientoniewski, Ian Rambo, Jacqueline Nesbit, Hsiaopo Cheng, Stephen Gipson, Stacie Jones, Dieu Doan, S. Shahzad Mustafa, Scott Smith, Michael Kulis, Adam Rivers, Alexander Foo, Geoffrey Mueller, Soheila Maleki
Journal: Journal of Allergy and Clinical Immunology (2025)
Dupilumab Leads To Rapid And Sustained Improvements In Symptoms Of Dysphagia And Dysphagia-Related Pain In Patients With Eosinophilic Esophagitis (EoE): Post Hoc Analysis Of Part C Of The LIBERTY EoE TREET Study
Authors: Evan Dellon, Mirna Chehade, Albert Bredenoord, Jonathan Spergel, Changming Xia, Sarette Tilton, Eilish McCann, Tiffany Pela, Bram Raphael, Juby Jacob-Nara, Amr Radwan
Journal: Journal of Allergy and Clinical Immunology (2025)
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer
Authors: Slim Mzoughi, Megan Schwarz, Xuedi Wang, Deniz Demircioglu, Gulay Ulukaya, Kevin Mohammed, Habiba Zorgati, Denis Torre, Lewis E. Tomalin, Federico Di Tullio, Carlos Company, Yuliia Dramaretska, Marc Leushacke, Bruno Giotti, Tamsin RM Lannagan, Daniel Lozano-Ojalvo, Panagiotis Karras, Peter B. Vermeulen, Dan Hasson, Robert Sebra, Alexander M. Tsankov, Owen J. Sansom, Jean-Christophe Marine, Nick Barker, Gaetano Gargiulo, Ernesto Guccione
Journal: Nature Genetics (2025)
Impact of Gut Microbiota on Immune Reconstitution and Graft-Versus-Host Disease in Pediatric Hematopoietic Cell Transplantation
Authors: Hayfa Ramadan, Ahmed Abdelrahman, Asim Eisa Mohamed, Nusiba Elsanousi, Yosra altaher, Razaz. Elsafi, Aamer Lotfi, Mafaz Ombada, Nadir Adelrahmsan
Journal: Journal of Allergy and Clinical Immunology (2025)