tbuckley/cabot-search huggingface dataset:
Antifungal Drug Therapy: A Complete Guide for the Practitioner
Authors: Paul H. Jacobs, Lexie Nall
Journal: Annals of Internal Medicine (1991)

Antifungal therapy, Paul H. Jacobs dermatophytosis (ringworm) Donald L. Greer pityriasis (tinea) versicolor, tinea nigra, and piedra, Jan N. Faergemann superficial candida infections, Roderick J. Hay and D. Chester Kalter chromoblastomycosis, Roberto Arenas sporotrichosis, Amado Saul mycetoma, El Sheikh Mahgoub phaeohyphomycosis, Renoo Kotrajaras geotrichosis, Alexandro Bonifaz, et al lobomycosis (deloidean blastomycosis, Lobo's disease), Sebastiao A.P. Sampaio rhinosporidiosis, Merani Thianprasit mucormycosis, Fumihiko Abe cutaneous aspergillosis, Katsutaro Nishimoto coccidioidomycosis, John N. Galgiani cryptococcosis, Edouard Drouhet and Bertrand Dupont systemic candidiasis (candidiosis), Raza Aly north American blastomycosis, Bruce S. Klein paracoccidioidomycosis (South American blastomycosis), Angela Restrepo-Moreno histoplasmosis, Charles De Vroey and Dick De Clercq Africa histoplasmosis, Charles De Vroey and Dick De Clercq actinomycosis, Pablo Negroni, et al nocardiosis, John P. Utz treatment of fungal infections in the human immunodeficiency virus-infected individual, S. Ira Greene therapy in the immunosuppressed host, John W. Rippon therapy of fungal infections in children, Alvin H. Jacobs rare and unusual fungal diseases, Angkana Chaiprasert antifungal prophylaxis, Geert Cauwenbergh antifungal therapy of the future, Paul A.J. Janssen and Geert Cauwenbergh.
Tropical Surgery and Surgical Pathology.
Authors: Karuna Kumar Chatterji
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparative Effectiveness of Ddpcr for the Detection of Egfr Mutations.
Authors: Marissa Daniels, Krishna Sriram, Edwina Duhig, Belinda Clarke, Andrew Dettrick, David Godbolt, Kayla Tran, Morgan Windsor, Rishendran Naidoo, Kevin Matar, Robert Tam, Rayleen Bowman, Ian Yang, Kwun Fong
Journal: Journal of Thoracic Oncology (2013)
Abstract 1730: Intraplaque Hemorrhage and Statin Therapy Alter the Natural History of Carotid Atherosclerosis: A Prospective Three Year Observational Magnetic Resonance Imaging Investigation
Authors: Hunter R Underhill, Chun Yuan, Baocheng Chu, Wei Yu, Minako Oikawa, Thomas S Hatsukami
Journal: Circulation (2006)

Purpose: Contrast enhanced magnetic resonance imaging (CE-MRI) has been validated with histology to accurately identify the lipid-rich necrotic core (LRNC), calcification (CA) and intra-plaque hemo...
Abstract 18041: RNAseq Identifies Differential Expression of Platelet Transcripts Between Hyper and Hypo-Aggregation to Collagen
Authors: Rehan Qayyum, Nauder Faraday, Diane M Becker, Brian G Kral, Lewis C Becker
Journal: Circulation (2013)

Background: Platelet aggregation plays an important role in the pathogenesis of myocardial infarction, and high platelet aggregability is associated with increased risk of events. We hypothesized that inter-individual variability in platelet function is associated with differences in the mRNA transcripts found in platelets from hyper-aggregators and hypo-aggregators. Methods: Ten individuals with family history of early onset coronary artery disease were enrolled. Individuals were divided into hyper- and hypo-aggregators based on maximal aggregation to collagen using whole blood impedance aggregometry. RNA was extracted from leukocyte-depleted platelet-rich plasma and approximately 70 million 100bp paired-end reads per sample were obtained using an Illumina HiSeq 2500. RNA-seq analysis was performed using Bowtie/TopHat/Cufflinks software pipeline. Genes with expression ≥ 0.3 fragments per kilobase of transcript per million reads (FPKM) were considered to be expressed. Genes with ≥ 2-fold change in expression on log2 scale and FDR&lt;0.1 were considered to be significantly differentially expressed. Results: Study sample consisted of 2 females and 3 males in each group. Among the 12,105 expressed genes, the most highly expressed nonubiquitous genes included GPX1, PPBP, PF4, &amp; TUBB1, confirming our methodologies. Hyper-aggregability was associated with up-regulation of 69 genes (such as MTRNR2L1 [anti-apoptotic], DEFA1 [innate immune response], and MYL4 [myosin light chain]). On the other hand, 50 genes were significantly down-regulated in hyper-aggregators (such as CCL3L1 [chemotactic for lymphocytes], CXCL5 [chemokine], and TUBB2A[beta-tubulin]). Gene ontology enrichment analysis found that genes related to innate immune response were up-regulated while genes related to B- and T-lymphocyte regulation were down-regulated in hyper-aggregators. Conclusion: RNA-seq and gene ontology analyses found that hyper- and hypo-aggregators have significant differences in gene expression. Increased expression of innate immune pathway genes in hyper-aggregators highlights the relationship of inflammation with increased platelet aggregation and suggests a role of platelets in innate immune response.
Lehrbuch der allgemeinen Physiologie.
Authors: Ernst Gellhorn
Journal: Annals of Internal Medicine (1931)

As the title indicates, this volume is a textbook of general physiology designed for students interested in the field. Written from the point of view first expressed by Claude-Bernard, the author does a most creditable and systematic job. At the end of each chapter there is a comprehensive bibliography. In succeeding chapters one finds a discussion of the cell as a physicochemical system, chemistry of cell processes, energetics of the living substance, the cell as a morphologic system, general physiology of cell development and architecture, general physiology of irritable processes, and tropisms. The practicing physician will not find the book serviceable to him although the phenomena discussed are at the basis of, or tantamount with, life itself.
A prospective randomized phase II trial of splenic irradiation (SI) versus supportive therapy (ST) for patients (Pts) with hypersplenism (HS) secondary (2ry) to splenic periportal fibrosis (SPPF)
Authors: S. Eid, E. Elbeih, A. Hamid, S. Helal
Journal: Journal of Clinical Oncology (2006)

16511 Background: HS 2ry to SPPF is a common problem in Egypt as a result of prevalence of bilharziasis. ST is the only option for the majority of pts who have poor performance status (PS) and cannot tolerate/refuse surgery. Methods: Aim of study was to evaluate the effect of SI versus ST on patients with HS 2ry to SPPF. Assessment of treatment was based on changes in Red Cell indices (RCI), Platelet indices (PI), splenic volume (SVol), and splenic vein diameter (SVD). In this study we had 19 evaluable Pts, 10 had SI and 9 had ST. Those who received SI had a twice weekly course of 1.5 Gy for a total of 3 weeks. RCI &amp; PI were measured each visit, SVol &amp; SVD (measured by duplex-Doppler US were measured initially, 3 &amp; 6 months (mos) after treatment). Results: SVol &amp; SVD increased significantly after 3 and 6 mos of ST, compared to insignificant decrease after 3 and 6 mos of SI. Platelet count (PC) significantly increased in all follow-ups (FU) after SI till 1.5 years compared to insignificant decreases in ST group after 3 and 6 mos. FU of mean platelet volume (MPV) and platelet distribution width (PDW) increased in ST group and decreased significantly in SI. Red blood cell (RBC) count and hemoglobin (Hb) levels increased significantly after SI till 6 and 9 mos respectively compared to insignificant decrease in RBC count and significant decrease in Hb level after 6 mos of ST. Changes in white blood cell counts were insignificant. After SI, changes in SVol showed significant positive correlations with changes in SVD and significant negative correlations with changes in PC. Changes in MPV showed significant positive correlation with changes in SVD. Side-effects (SE) seen with SI were moderate and transient. Conclusions: SI is a promising new modality of treatment with acceptable SE for pts with HS. Dose and schedule of SI should be modified according to pts PS. Changes in SVD are highly correlated with the degree of platelet and red cell turnover. Its predictive value for HS should be studied further. No significant financial relationships to disclose.
Abstract 30: Incomplete Chest Recoil During Piglet CPR Worsens Hemodynamics
Authors: Mathias Zuercher, Ronald W Hilwig, Jon Nysaether, Vinay M Nadkarni, Marc D Berg, Gordon A Ewy, Karl B Kern, Robert A Berg
Journal: Circulation (2007)

Background : Incomplete chest recoil during cardiopulmonary resuscitation (CPR) (ie, leaning on the chest during the decompression phase) is purported to decrease venous return, and thereby decrease forward blood flow. Aim To determine the effect of 10% and 20% lean on hemodynamics during piglet CPR. Methods : 10 piglets (10.7±1.2 kg) were anesthetized with isoflurane and instrumented with micromanometer-tipped catheters in the right atrium (RA) and aorta (Ao). After induction of ventricular fibrillation, CPR was provided in three-minute epochs with no lean, 10% lean, or 20% lean while aortic systolic pressure (AoS) was targeted at 80–90 mmHg. Because the mean force to attain 80 –90 mm Hg AoS was 18 kg in preliminary studies, 10% and 20% lean were provided as 1.8 and 3.6 kg weights on the chest, respectively. Left ventricular myocardial blood flow (MBF) and cardiac index (CI) were determined by fluorescent, color-microsphere technique. Statistics: paired t -test and repeated measurement ANOVA for parametric, Wilcoxon Rank Sum Test and Friedman’s ANOVA for non-parametric data. Results : 10% and 20% lean resulted in higher right atrial diastolic pressure (RAD) and lower coronary perfusion pressure (CPP) than no lean. Hemodynamics were not different with 10% lean vs. 20% lean. Mean 10%–20% lean resulted in substantially lower MBF and CI than no lean (Table ). Conclusions : 10–20% leaning during CPR increases RAD, decreases CPP, and substantially decreases MBF and CI. Table
Targeting the vascular endothelial growth factor pathway in renal cell carcinoma: A tissue array based analysis
Authors: J. T. Leppert, J. S. Lam, H. Yu, D. B. Seligson, J. Dong, S. Horvath, A. J. Pantuck, A. S. Belldegrun, R. A. Figlin
Journal: Journal of Clinical Oncology (2005)

4536 Background: The Vascular Endothelial Growth Factor (VEGF) family includes distinct signaling pathways for angiogenesis and lymphangiogenesis. Understanding the expression of these markers may enhance selection of target specific therapies based on an individual’s unique tumor biology, and optimize the benefit of these agents in renal cell carcinoma (RCC). Methods: A tissue microarray was constructed from paraffin-embedded clear cell (n=340) and papillary (n=42) RCC specimens from patients treated with nephrectomy for localized or advanced disease. Immunohistochemistry was performed with antibodies directed against VEGF-A, VEGF-C, VEGF-D, VEGFR-1, VEGFR-2 and VEGFR-3. The percentage of tumor cells expressing each marker was scored in 3 locations and averaged. Expression of the receptors within tumor associated endothelium was also scored and averaged. The Kruskal-Wallis test was used to compare the expression of each marker between the two tumor histologies. Results: When examining the angiogenesis pathway, papillary RCC demonstrated a higher mean expression of VEGF-A and VEGFR-2 than clear cell RCC, while no difference was seen in the expression of VEGFR-1. Within the lymphangiogenesis pathway, clear cell RCC demonstrated a higher mean expression of VEGF-D, while papillary RCC demonstrated higher mean expression of VEGFR-3 and no difference was seen in the mean expression of VEGF-C. Within tumor associated endothelium, clear cell RCC demonstrated higher mean staining for VEGFR-1, VEGFR-2 and VEGFR-3. Conclusions: This data suggests that patients with papillary RCC should be considered for therapies targeting the VEGF-A pathway. Patients with clear cell RCC may be more likely to benefit from receptor kinase inhibitors targeting VEGFR-3. Knowledge of the expression of the VEGF family, regardless of histology, may guide future patient selection for anti-angiogenesis therapies. No significant financial relationships to disclose.
Diagnose und Therapie der Hauttuberkulose in der Praxis.
Authors: Georg Alexander Rost, Philipp Keller, Alfred Marchionini
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Who Goes First?: The Story of Self-Experimentation in Medicine.
Authors: Lawrence K. Altman
Journal: Annals of Internal Medicine (1987)

Reviewserosion of Catholic opposition made politicians less reluctant to contemplate decriminalizing contraception.This was accomplished in the 1969 revision of the Criminal Code but, the book convincingly argues, it did not end state interference in the bedrooms of the nation.Abortion remains a contentious issue and the provision of contraceptives has more to do with the male-dominated interests of government and business than with meeting women's needs.The authors make no claim to be comprehensive.The bulk of their material relates to the interwar years and concerns particular regions of the country.An in-depth study remains to be written and this useful survey, which says little about the shifts in family structure that the demographic changes entailed, should prompt further enquiry.
Abstract 15623: Non-Invasive, Bedside Imaging of Lymphatics in an Infant With Chylothorax After Congenital Heart Surgery
Authors: Duraisamy Balaguru, I-Chih Tan, Eva Sevick-Muraca, Renie Guilliod, Michael H Hines, William I Douglas, John Rasmussen
Journal: Circulation (2013)

Introduction: Chylothorax is a rare, but serious complication after congenital heart surgery in neonates. Management of this condition has been hampered by poor understanding of pathophysiology and...
Abstract 1336: Increased Enzyme Activity and Increased Beta-adrenergic-mediated Vasodilation in Subjects Expressing a Single Nucleotide Variant of Human Adenylyl Cyclase 6
Authors: Robert Gros, Stan Van Uum, Adam Hutchinson-Jaffe, Qingming Ding, J. Geoffrey Pickering, Robert A Hegele, Ross D Feldman
Journal: Circulation (2007)

Cyclic AMP is a critical regulator of metabolic and cardiovascular function. Alterations in adenylyl cyclase (AC) regulation have been implicated in the pathogenesis and/or maintenance of insulin resistance, obesity, hypertension and heart failure. However, the role of genetic variability in the regulation of cyclic AMP-mediated effects is unclear. Therefore, we examined the role of a recently identified missense genetic variant of human AC isoform 6 (AC6 S674) in a sample of Caucasian subjects. We assessed the effect of AC6 S674 expression on AC-mediated function in adherent mononuclear leukocyte fractions and on beta-adrenergic-mediated vasodilation in human subjects. In addition, we examined the role of AC6 S674 on AC activity and cytoskeletal reorganization of rat vascular smooth muscle cells (VSMCs) following AC6 S674 gene transfer. In adherent mononuclear leukocytes isolated from AC6 S674-expressing individuals, forskolin-stimulated AC activity was significantly increased as compared to wild-type AC6 (WT AC6)-expressing subjects (WT AC6: 104±19 vs. AC6 S674: 193±33 pmol/min/mg protein, n=12, p&lt;0.05). Similarly, forskolin-mediated cytoskeletal reorganization of adherent mononuclear leukocytes from AC6 S674 expressing subjects was significantly increased as compared to WT AC6 control subjects (154±18% of WT AC6, p&lt;0.05). In dorsal hand vein vascular reactivity studies, subjects expressing the AC6 S674 variant had significantly greater vascular sensitivity to the beta-adrenergic agonist isoproterenol as assessed by both a greater potency and greater maximal effect than in subjects expressing WT AC6. In rat VSMCs, gene transfer of AC6 S674 increased forskolin-stimulated AC activity as compared to WT AC6-infected rat VSMCs (141±18% of AC6 WT, n=8, p&lt;0.05). Similarly, forskolin-induced cytoskeletal reorganization was significantly greater in AC6 S674 expressing VSMCs than in WT AC6 expressing VSMCs (139±15% of WT AC6, n=6, p&lt;0.05). In summary, these data indicate that the expression of a novel, relatively common variant of human AC6 parallels an increase in adenylyl cyclase activity and AC-mediated function both in humans.
Modern Marriage. A Handbook.
Authors: Paul Popenoe
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proctocolectomy and Ileostomy for Ulcerative Colitis: The Longer Term Story
Authors: R K S Phillips, J K Ritchie, P R Hawley
Journal: Journal of the Royal Society of Medicine (1989)

Elective surgery for ulcerative colitis usually involves the removal of the entire large bowel with either a conventional ileostomy or the formation of an ileoanal pouch anastomosis. Seventy patients undergoing a one stage elective total proctocolectomy and ileostomy between 1976 (the first year an ileoanal pouch was carried out in this hospital) and 1986 have been studied. We have confirmed that proctocolectomy and ileostomy for ulcerative colitis is not the trouble free operation many presume it to be when considering the alternative of an ileoanal pouch.
Fasting and Undernutrition. A Biological and Sociological Study of Inanition.
Authors: Sergius Morgulis
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clearance Tests in Clinical Medicine.
Authors: François C. Reubi
Journal: Annals of Internal Medicine (1964)

end with a list of normal values. Much of this last could have been omitted without loss. The text itself is an exhaustive, well-documented review of an important area in which many of us need authoritative guidance. While concerned mostly with myocardial infarction, it yields a wealth of concise information on clinical and chemical aspects of other heart disease. The jacket recommends it to the cardiologist, internist, and practic¬ ing physician. This is fair. It should also be read by residents and heart trainees and