tbuckley/cabot-search huggingface dataset:
Core decompression combined with bone marrow mononuclear cells in the treatment of femoral head necrosis: a systematic review and meta-analysis
Authors: Ying Zhu, Peiyuan Tang, Hua Chai, Wenbo Ma, Yangbin Cao, Han Tan, Bin Lin, Wenfeng Xiao, Ting Wen, Yusheng Li
Journal: International Journal of Surgery (2024)

Background: The effectiveness of bone marrow mononuclear cells (BMMCs) combined with core decompression (CD) in the treatment of femoral head necrosis is controversial. The purpose of this study was to conduct a meta-analysis and systematic review of the evaluation of BMMCss combined with CD in the treatment of femoral head necrosis and to compare the therapeutic effect of this method with that of CD alone so as to provide a basis for subsequent research and clinical treatment. Methods: We conducted detailed searches across four databases in Embase, PubMed, Web of Science, and the Cochrane Library (up to October 2023), including eight studies with a total of 370 participants and 491 hip cases. This meta-analysis followed the Preferred Reporting Project (PRISMA) guidelines. Review Manager 5.4 was used to summarize and analyze the outcome indicators and the quality and reliability of the MAs were graded against a Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2). Results: Eight studies were included in the inclusion criteria. The results of meta-analysis showed that the therapeutic effect of CD combined with BMMC on visual analog scale was better than that of CD alone [mean difference (MD)=−5.32, 95% confidence interval (CI): −9.90, −0.74, P =0.02, I 2 =98%], and there was no statistically significant difference between CD combined with BMMC and CD alone in the treatment of Harris hip score (MD=2.73, 95% CI: −2.63, 8.09, P =0.32, I 2 =82%). We conducted a sensitivity analysis. The results showed that the CD joint BMMC treatment effect on the Harris hip score is superior to the single CD (MD=5.57, 95% CI: 1.94, 9.20, P =0.003, I 2 =0%), both no significant differences in visual analog scale (MD=0.47, 95% CI: −1.74, 0.79, P =0.46, I 2 =83%). Conclusion: In this study, we found that CD combined with bone marrow monocyte therapy improved femoral head necrosis better than CD alone.
Aryl hydrocarbon receptor repressor (AHRR) methylation predicts risk of vascular disease: A cohort study of the general population
Authors: Sune M. Skov-Jeppesen, Camilla J. Kobylecki, Katja K. Jacobsen, Stig E. Bojesen
Journal: International Journal of Surgery (2024)

Smoking is a risk factor for cardiovascular disease, but there is currently no clinically established biomarker for its cardiovascular damage. We aimed to investigate the hypothesis that aryl hydrocarbon receptor repressor (AHHR) methylation at CpG site cg05575921, a biomarker of smoking behavior, is associated with the risk of peripheral artery disease (PAD) and aortic aneurysm (AA) in the general population.
Treatment of sleep apnoea early after myocardial infarction with adaptive servo-ventilation: a proof-of-concept randomised controlled trial
Authors: Michael Arzt, Henrik Fox, Stefan Stadler, Andrea Hetzenecker, Olaf Oldenburg, Okka W. Hamer, Florian Poschenrieder, Clemens Wiest, Radu Tanacli, Sebastian Kelle, Leonhard Bruch, Mirko Seidel, Michael Koller, Florian Zeman, Stefan Buchner
Journal: European Respiratory Journal (2024)

Background Sleep disordered breathing (SDB) has been associated with less myocardial salvage and smaller infarct size reduction after acute myocardial infarction (AMI). The Treatment of sleep apnoea Early After Myocardial infarction with Adaptive Servo-Ventilation (TEAM-ASV I) trial investigated the effects of adding adaptive servo-ventilation (ASV) for SDB to standard therapy on the myocardial salvage index (MSI) and change in infarct size within 12 weeks after AMI. Methods In this multicentre, randomised, open-label trial, patients with AMI and successful percutaneous coronary intervention within 24 h after symptom onset plus SDB (apnoea–hypopnoea index ≥15 events·h −1 ) were randomised to standard medical therapy alone (control) or plus ASV (starting 3.6±1.4 days post-AMI). The primary outcome was the MSI at 12 weeks post-AMI. Cardiac magnetic resonance (CMR) imaging was performed at ≤5 days and 12 weeks after AMI. Results 76 individuals were enrolled from February 2014 to August 2020; 39 had complete CMR data for analysis of the primary end-point. The MSI was significantly higher in the ASV versus control group (difference 14.6% (95% CI 0.14–29.1%); p=0.048). At 12 weeks, absolute (6.6 (95% CI 4.8–8.5) versus 2.8 (95% CI 0.9–4.8) % of left ventricular mass; p=0.003) and relative (44 (95% CI 30–57) versus 21 (95% CI 6–35) % of baseline; p=0.013) reductions in infarct size were greater in the ASV versus control group. No serious treatment-related adverse events occurred. Conclusions Early treatment of SDB with ASV improved the MSI and decreased infarct size at 12 weeks after AMI. Larger randomised trials are required to confirm these findings.
Routine end-ischemic hypothermic machine perfusion in liver transplantation from donors after brain death: results of two-year follow-up of a randomized controlled trial
Authors: Marcin Morawski, Andriy Zhylko, Paweł Rykowski, Maciej Krasnodębski, Wacław Hołówko, Zbigniew Lewandowski, Magdalena Mielczarek-Puta, Marta Struga, Benedykt Szczepankiewicz, Barbara Górnicka, Marek Krawczyk, Michał Grąt
Journal: International Journal of Surgery (2024)

Data on routine hypothermic machine perfusion of livers procured from donors after brain death (DBD) are scarce, and the benefits of the method have only been demonstrated in extended criteria grafts. The aim of this study was to assess if end-ischemic dual hypothermic oxygenated machine perfusion (dHOPE) is superior to static cold storage (SCS) in preservation of livers procured from DBD donors with respect to long-term outcomes. Existing data on short-term outcomes favours dHOPE in patients receiving high-risk grafts.
Smoking and vaping alter genes related to mechanisms of SARS-CoV-2 susceptibility and severity
Authors: Rachel Bowsher, Timothy H Marczylo, Karen Gooch, Alexis Bailey, Matthew D Wright, Emma L Marczylo
Journal: European Respiratory Journal (2024)

Background Evidence for the impact of smoking on coronavirus disease 2019 (COVID-19) is contradictory, and there is little research on vaping. Here we provide greater clarity on mechanisms perturbed by tobacco cigarette, electronic cigarette and nicotine exposures that may impact the risks of infection and/or disease severity. Methods Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the Ovid and Web of Science databases were searched. Study design and exposure-induced gene expression changes were extracted. Each study was quality assessed and higher confidence scores were assigned to genes consistently changed across multiple studies following the same exposure. These genes were used to explore pathways significantly altered following exposure. Results 125 studies provided data on 480 genes altered by exposure to tobacco cigarettes, e-cigarettes, nicotine or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Genes involved in both SARS-CoV-2 viral-entry and inflammation were changed following exposure. Pathway analysis revealed that many of those genes with high confidence scores are involved in common cellular processes relating to hyperinflammatory immune responses. Conclusion Exposure to tobacco cigarettes, e-cigarettes or nicotine may therefore impact initial host–pathogen interactions and disease severity. Smokers and vapers of e-cigarettes with nicotine could potentially be at increased risk of SARS-CoV-2 infection, associated cytokine storm, and acute respiratory distress syndrome. However, further research is required, particularly on e-cigarettes, to determine the biological mechanisms involved in perturbation of viral-entry genes and host–pathogen interactions and subsequent responses within the respiratory tract. This will improve our physiological understanding of the impact of smoking and vaping on COVID-19, informing public health advice and providing improved guidance for management of SARS-CoV-2 and other respiratory viruses.
Effect of remimazolam besylate vs propofol on incidence of postoperative delirium in older patients undergoing hip surgery: a randomized Non-inferiority trial
Authors: Pan-Pan Fang, Jun Hu, Qing-Feng Wei, Yong-Jie Liang, Yin-Guang Fan, Qi-Ying Shen, Yao Lu, Xue-Sheng Liu, Mervyn Maze
Journal: International Journal of Surgery (2024)
Salvage surgery and conversion surgery for patients with non-small cell lung cancer: A narrative review
Authors: Hao-Ji Yan, Xiang-Yun Zheng, Ya-Ting Zeng, Jia-Xin Wan, Jing Chen, Zhi-Qiang Deng, Yu-Yang Mao, Wen-Long Hu, Jun-Jie Zhang, Ai-Ling Zhong, Chun-Yan Zhao, Wen-Jun Mao, Dong Tian
Journal: International Journal of Surgery (2024)
A range of 30%–62% of functioning multiciliated airway cells is sufficient to maintain ciliary airway clearance
Authors: Niki T. Loges, June Kehlet Marthin, Johanna Raidt, Heike Olbrich, Inga M. Höben, Sandra Cindric, Diana Bracht, Julia König, Cynthia Rieck, Sebastian George, Tim Luis Kloth, Kai Wohlgemuth, Petra Pennekamp, Bernd Dworniczak, Mathias G. Holgersen, Jobst Römel, Christian Schmalstieg, Isabella Aprea, Jann Mortensen, Kim G. Nielsen, Heymut Omran
Journal: European Respiratory Journal (2024)

Primary ciliary dyskinesia is a genetic disorder caused by aberrant motile cilia function that results in defective ciliary airway clearance and subsequently leads to recurrent airway infections and bronchiectasis. We aimed to determine: how many functional multiciliated airway cells are sufficient to maintain ciliary airway clearance?
Feasibility and accuracy of robot-assisted tunnel placement in anatomic arthroscopic posterior cruciate ligament reconstruction
Authors: Gang Yang, Hong-Jie Huang, Jia-Yi Shao, Ding-Ge Liu, Kai-Ping Liu, Zhi-Hua Zhang, Lang-Ran Wang, Qi-Ning Wang, Zhi-Hao Zhou, Jian-Quan Wang, Xin Zhang
Journal: International Journal of Surgery (2024)
Deep phenotyping of unaffected carriers of pathogenic<i>BMPR2</i>variants screened for pulmonary arterial hypertension
Authors: Eszter N. Tóth, Lucas R. Celant, Marili Niglas, Samara Jansen, Jelco Tramper, Nicoleta Baxan, Ali Ashek, Jeroen N. Wessels, J. Tim Marcus, Lilian J. Meijboom, Arjan C. Houweling, Esther J. Nossent, Jurjan Aman, Julien Grynblat, Frédéric Perros, David Montani, Anton Vonk Noordegraaf, Lan Zhao, Frances S. de Man, Harm Jan Bogaard
Journal: European Respiratory Journal (2024)

Pathogenic variants in the gene encoding for
Medical hypnosis mitigates laboratory dyspnoea in healthy humans: a randomised, controlled experimental trial
Authors: Capucine Morélot-Panzini, Cécile Arveiller-Carvallo, Isabelle Rivals, Nicolas Wattiez, Sophie Lavault, Agnès Brion, Laure Serresse, Christian Straus, Marie-Cécile Niérat, Thomas Similowski
Journal: European Respiratory Journal (2024)

Question Dyspnoea persisting despite treatments of underlying causes requires symptomatic approaches. Medical hypnosis could provide relief without the untoward effects of pharmacological approaches. We addressed this question through experimentally induced dyspnoea in healthy humans (inspiratory threshold loading (excessive inspiratory effort) and carbon dioxide stimulation (air hunger)). Material and methods 20 volunteers (10 women, aged 21–40 years) were studied on four separate days. The order of the visits was randomised in two steps: firstly, the “inspiratory threshold loading first” versus “carbon dioxide first” group (n=10 in each group); secondly, the “medical hypnosis first” versus “visual distraction first” subgroup (n=5 in each subgroup). Each visit comprised three 5-min periods (reference, intervention, washout) during which participants used visual analogue scales (VAS) to rate the sensory and affective dimensions of dyspnoea, and after which they completed the Multidimensional Dyspnea Profile. Results Medical hypnosis reduced both dimensions of dyspnoea significantly more than visual distraction (inspiratory threshold loading: sensory reduction after 5 min 34% of full VAS versus 8% (p=0.0042), affective reduction 17.6% versus 2.4% (p=0.044); carbon dioxide: sensory reduction after 5 min 36.9% versus 3% (p=0.0015), affective reduction 29.1% versus 8.7% (p=0.0023)). The Multidimensional Dyspnea Profile showed more marked sensory effects during inspiratory threshold loading and more marked affective effects during carbon dioxide stimulation. Answer to the question Medical hypnosis was more effective than visual distraction at attenuating the sensory and affective dimensions of experimentally induced dyspnoea. This provides a strong rationale for clinical studies of hypnosis in persistent dyspnoea patients.
A bibliometric and visualization analysis of global research status and frontiers on autophagy in cardiomyopathies from 2004 to 2023
Authors: Xianghui Zeng, Bin Shu, Qingfeng Zeng, Xianggui Wang, Kening Li, Jincheng Wu, Jianping Luo
Journal: International Journal of Surgery (2024)

Background: Autophagy is intimately associated with the development of cardiomyopathy, and has received widespread attention in recent years. However, no relevant bibliometric analysis is reported at present. In order to summarize the research status of autophagy in cardiomyopathy and provide direction for future research, we conducted a comprehensive, detailed, and multidimensional bibliometric analysis of the literature published in this field from 2004 to 2023. Methods: All literatures related autophagy in cardiomyopathy from 2004 to 2023 were collected from the Web of Science Core Collection (WOSCC), and annual papers, global publication trends and proportion charts were analyzed and plotted using Graphpad price v8.0.2. In addition, CtieSpace (6.2.4R (64 bit) Advanced Edition) and VOSviewer (1.6.18 Edition) were used to analyze and visualize these data. Results: 2279 papers about autophagy in cardiomyopathy were accessed in the WoSCC over the last 20 years, comprising literatures from 70 countries and regions, 2208 institutions, and 10,810 authors. China contributes 56.32% of the total publications, substantially surpassing other countries, while the U.S. is ranked first in frequency of citations. Among the top 10 authors, 6 are from China and 4 are from the United States. Air Force Military Medical University was the institution with the highest number of publications; while journal of molecular and cellular cardiology (62 articles, 2.71% of the total) was the journal with the highest number of papers published in the field. Clustering of co-cited references and temporal clustering analysis showed that ferroptosis, hydrogen sulfide mitophagy, lipid peroxidation, oxidative stress, and SIRT-1 are hot topics and trends in the field. The principal keywords are oxidative stress, heart and heart-failure. Conclusion: The research on autophagy in cardiomyopathy is in the developmental stage. This represents the first bibliometric analysis of autophagy in cardiomyopathy , revealing the current research hotspots and future research directions in this field.
Bi-allelic variants in RINT1 present as early-onset pure hereditary spastic paraplegia
Authors: Vicente Quiroz, Laura Planas-Serra, Abigail Sveden, Amy Tam, Hyo-Min Kim, Umar Zubair, Dario Resch, Afshin Saffari, Matt C. Danzi, Stephan Züchner, Maya Chopra, Luca Schierbaum, Aurora Pujol, Erik A. Eklund, Darius Ebrahimi-Fakhari
Journal: Journal of Clinical Investigation (2024)
Randomised controlled trial reveals no benefit to a 3-month delay in COVID-19 mRNA booster vaccine
Authors: Wen Shi Lee, Jennifer Audsley, Mai-Chi Trieu, Arnold Reynaldi, L. Carissa Aurelia, Palak H. Mehta, Joanne Patterson, Helen E. Kent, Julie Nguyen, Thakshila Amarasena, Robyn Esterbauer, Ebene R. Haycroft, Pradhipa Ramanathan, Miles P. Davenport, Timothy E. Schlub, Joseph Sasadeusz, Adam K. Wheatley, Amy W. Chung, Jennifer A. Juno, Kevin J. Selva, Stephen J. Kent
Journal: Journal of Clinical Investigation (2024)

BACKGROUNDThere is uncertainty about the timing of booster vaccination against COVID-19 in highly vaccinated populations during the present endemic phase of COVID-19. Studies focused on primary vaccination have previously suggested improved immunity with a longer interval between the first and second vaccine doses.METHODSWe conducted a randomized, controlled trial (November 2022-August 2023) and assigned 52 fully vaccinated adults to an immediate or a 3-month delayed bivalent Spikevax mRNA booster vaccine. Follow-up visits were completed for 48 participants (n = 24 per arm), with collection of saliva and plasma samples following each visit.RESULTSThe rise in neutralizing antibody responses to ancestral and Omicron strains were almost identical between the immediate and delayed vaccination arms. Analyses of plasma and salivary antibody responses (IgG, IgA), plasma antibody-dependent phagocytic activity, and the decay kinetics of antibody responses were similar between the 2 arms. Symptomatic and asymptomatic SARS-CoV-2 infections occurred in 49% (21 of 49) participants over the median 11.5 months of follow-up and were also similar between the 2 arms.CONCLUSIONSOur data suggest that there was no benefit in delaying COVID-19 mRNA booster vaccination in preimmune populations during the present endemic phase of COVID-19.TRIAL REGISTRATIONAustralian New Zealand Clinical Trials Registry number 12622000411741 (https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12622000411741).FUNDINGNational Health and Medical Research Council, Australia (program grant App1149990) and Medical Research Future Fund (App2005544).
Measurable Residual Disease and Clinical Outcomes in Chronic Lymphocytic Leukemia
Authors: Fausto Alfredo Rios-Olais, Alyssa K. McGary, Mazie Tsang, Diana Almader-Douglas, Jose F. Leis, Matthew R. Buras, Talal Hilal
Journal: JAMA Oncology (2024)

Measurable residual disease (MRD) refers to the presence of disease at low levels not detected by conventional pathologic analysis. The association of MRD status as a surrogate end point of clinical outcome in chronic lymphocytic leukemia (CLL) has not been established in the era of targeted agents. Assessing the association of MRD with progression-free survival (PFS) may improve its role as a surrogate marker and allow its use to accelerate drug development.
Initial Management of <i>BRAF </i>V600E-Variant Anaplastic Thyroid Cancer
Authors: Sarah Hamidi, Ramona Dadu, Mark E. Zafereo, Renata Ferrarotto, Jennifer R. Wang, Anastasios Maniakas, G. Brandon Gunn, Anna Lee, Michael T. Spiotto, Priyanka C. Iyer, Luana G. Sousa, Neal S. Akhave, Salmaan Ahmed, Kim O. Learned, Charles Lu, Stephen Y. Lai, Michelle Williams, S. Mohsen Hosseini, Naifa L. Busaidy, Maria E. Cabanillas
Journal: JAMA Oncology (2024)

BRAF/MEK inhibitors revolutionized the treatment of BRAF V600E-variant anaplastic thyroid carcinoma (BRAFv-ATC), offering improved outcomes for patients with this previously incurable disease.
Response-Adapted Ultralow-Dose Radiation Therapy for Orbital Indolent B-Cell Lymphoma
Authors: Chelsea C. Pinnix, Bouthaina S. Dabaja, Jillian R. Gunther, Penny Q. Fang, Susan Y. Wu, Loretta J. Nastoupil, Paolo Strati, Ranjit Nair, Sairah Ahmed, Raphael Steiner, Jason Westin, Sattva Neelapu, Maria A. Rodriguez, Hun Ju Lee, Michael Wang, Christopher Flowers, Lei Feng, Bita Esmaeli
Journal: JAMA Oncology (2024)

Radiation therapy to doses of 24 to 36 Gy is currently used to treat indolent B-cell lymphoma of the ocular adnexa; however, ocular adverse effects are common.
Sodium Intake and Incident Atrial Fibrillation in Individuals With Vascular Disease
Authors: Linda S. Johnson, Andrew Mente, Philip Joseph, David Conen, Alexander P. Benz, William F. McIntyre, Isabel Drake, Gunnar Engström, Stuart J. Connolly, Salim Yusuf, Jeffrey S. Healey
Journal: JAMA Network Open (2024)

Importance Numerous prospective cohort studies have reported a J-shaped association of urinary sodium excretion with cardiovascular events and mortality. Objective To study the association between sodium intake and incident atrial fibrillation (AF). Design, Setting, and Participants This cohort study included participants in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET) and Telmisartan Randomised Assessment Study in ACE Intolerant Subjects With Cardiovascular Disease (TRANSCEND) multicenter, randomized clinical trials comparing the effect of ramipril 10 mg daily with telmisartan 80 mg daily, or their combination (ONTARGET) or 80 mg telmisartan daily with placebo (TRANSCEND) for the outcome of death from cardiovascular causes, myocardial infarction, stroke, or hospitalization for heart failure. ONTARGET and TRANSCEND included 31 546 participants with vascular disease or high-risk diabetes, and this study excluded participants without a urine sample for sodium measurement, missing data for key covariates, a history of AF, or AF detected in the first year after enrollment. Analyses were performed in July 2023 to May 2024. Exposure Estimated sodium intake from a morning fasting urine sample (Kawasaki formula). Main Outcomes and Measures The main outcome was incident AF. The association between estimated sodium intake and incident AF was modeled using multivariable adjusted Cox regression and cubic splines. Results A total of 27 391 participants (mean [SD] age, 66.3 [7.2] years; 19 310 [70.5%] male) were included. Mean (SD) estimated sodium intake was 4.8 (1.6) g/d. During a mean (SD) follow-up of 4.6 (1.0) years, 1562 participants (5.7%) had incident AF. After multivariable adjustment, a J-shaped association between sodium intake and AF risk was observed ( P for nonlinearity = .03). Sodium intake of 8 g/d or greater (3% of participants) was associated with incident AF (hazard ratio, 1.32; 95% CI, 1.01-1.74) compared with sodium intake of 4 to 5.99 g/d. Cubic splines showed that sodium intake greater than 6 g/d (19% of participants) was associated with a 10% increased AF risk per additional 1-g/d sodium intake (hazard ratio, 1.10; 95% CI, 1.03-1.18), but with no further lowering of AF risk at lower levels of sodium intake. Conclusions and Relevance In this cohort study of sodium intake and AF risk, there was a J-shaped association between sodium intakes and AF risk in patients with cardiovascular disease or diabetes. Lowering sodium intake for AF prevention is best targeted at individuals who consume high sodium diets.