tbuckley/cabot-search huggingface dataset:
Patterns of psychiatric comorbidity, cognition, and psychosocial functioning in adults with attention deficit hyperactivity disorder
Authors: J Biederman, S V Faraone, T Spencer, T Wilens, D Norman, K A Lapey, E Mick, B K Lehman, A Doyle
Journal: American Journal of Psychiatry (1993)

Although attention deficit hyperactivity disorder is a common disorder of childhood, its status as a disorder in adults is not clear. The authors reasoned that if the adult diagnosis of the disorder is a valid clinical entity, it should be similar to the childhood disorder with regard to patterns of psychiatric and cognitive findings.Eighty-four adults with a clinical diagnosis of childhood-onset attention deficit hyperactivity disorder confirmed by structured interview who were referred for treatment were studied. Findings were compared with those from a preexisting study group of referred children with attention deficit hyperactivity disorder, nonreferred adult relatives of those children who also had attention deficit hyperactivity disorder, and adults without the disorder who were relatives of normal children. Subjects were evaluated with a comprehensive battery of psychiatric, cognitive, and psychosocial assessments.The referred and nonreferred adults with attention deficit hyperactivity disorder were similar to one another but more disturbed and impaired than the comparison subjects without the disorder. The pattern of psychopathology, cognition, and functioning among the adults with attention deficit hyperactivity disorder approximated the findings for children with the disorder.These results show that referred and nonreferred adults with attention deficit hyperactivity disorder have a pattern of demographic, psychosocial, psychiatric, and cognitive features that mirrors well-documented findings among children with the disorder. These findings further support the validity of the diagnosis for adults.
OBSERVATIONS ON IMMUNITY IN MUMPS
Authors: John F. Enders
Journal: Annals of Internal Medicine (1943)

Article1 June 1943OBSERVATIONS ON IMMUNITY IN MUMPSJOHN F. ENDERS, PH.D.JOHN F. ENDERS, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-6-1015 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe importance of the problems of the control and prevention of mumps among military personnel was illuminated by the events of the last war when nearly four million man days were lost from duty because of this disease. Wesselhoeft and Walcott1 recently, in an excellent review, have reëmphasized the rôle which epidemic parotitis can play in interfering seriously with the training and movements of troops and have clearly defined the lacunae in our knowledge and our technic which have rendered prevention and control unsatisfactory.Of these deficiencies perhaps that most keenly felt is the lack of a simple method analogous...Bibliography1. WESSELHOEFTWALCOTT CCF: Mumps as a military disease and its control, War Med., 1942, ii, 213. Google Scholar2. JOHNSONGOODPASTURE CDEW: An investigation of the etiology of mumps, Jr. Exper. Med., 1934, lix, 1. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Presented before the New England Regional Meeting of the American College of Physicians, Boston, February 5, 1943.From the Department of Bacteriology and Immunology, Harvard Medical School and School of Public Health, Boston, Mass.A part of the work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the President and Fellows of Harvard College.The data supporting the statements made in this paper will be recorded in detail in subsequent communications. A preliminary report on the development of complement-fixing antibodies in infected monkeys and in human beings with mumps has been published (Proc. Soc. Exper. Biol. and Med., 1942, 1, 180-184). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMyxovirenZur einseitigen Taubheit im KindesalterVariability of the intrathecal response to antigensMumps VirusDie Bedeutung der Myxo-, Adeno-, Coxsackie-und Echo-Viren für die DermatologieLXVII Inner Ear Pathology in Deafness Due to MumpsDeafness Following MumpsSalivary Gland InfectionA SKIN TEST FOR MUMPSDie spezifische Diagnose der MumpsinfektionSkin Tests in Mumps Meningo-Encephalitis1Complement Fixation Tests for Diagnosis of Mumps Applied to Typical and Suspect Cases of Mumps Meningo-Encephalitis.Ocular Manifestations of Mumps 1 June 1943Volume 18, Issue 6Page: 1015-1019KeywordsAntibodiesArmed forcesBacteriologyImmunityImmunologyMumpsPrevention, policy, and public health ePublished: 1 December 2008 Issue Published: 1 June 1943 PDF downloadLoading ...
Adenosine and Clinical Forms of Neurally-Mediated Syncope
Authors: Regis Guieu, Jean-Claude Deharo, Jean Ruf, Giovanna Mottola, Nathalie Kipson, Laurie Bruzzese, Victoria Gerolami, Frederic Franceschi, Andrea Ungar, Marco Tomaino, Matteo Iori, Michele Brignole
Journal: Journal of the American College of Cardiology (2015)
Pilot study of the novel chemotherapy regimen of topotecan, ifosfamide, and carboplatin (TIC) in children with refractory/recurrent solid tumors.
Authors: A. Lee, C. Handler, L. Harrison, W. V. Shen, L. Gates, R. J. Wells, J. E. Wolff, J. H. Garvin, D. Yamashiro, M. S. Cairo
Journal: Journal of Clinical Oncology (2010)

9545 Background: The combination of ifosfamide, carboplatin, and etoposide (ICE) has previously been demonstrated to be an effective regimen in children with recurrent or refractory solid tumors (Cairo et al JPHO, 2001). Substituting topotecan (a Topoisomerase I inhibitor) for etoposide (a Topoisomerase II inhibitor) may be a more efficacious regimen due to the cytotoxic activity of topotecan in pediatric solid tumor xenografts, as well as its in vitro synergistic activity with platinum and alkylating agents (Houghton et al CCP, 1992). Methods: In this limited institution study, we evaluated the addition of escalating doses of topotecan with fixed doses of ifosfamide and carboplatin. Patients initially received ifosfamide 3,000 mg/m2/day × 3 days, carboplatin dosed to an AUC of 3 mg/ml/min (equivalent to 250 mg/m2/dose) × 3 days, and topotecan × 3 days. 6 patients were enrolled at dose level #1 (topotecan: 0.5 mg/m2/day), with 2 patients having ifosfamide related neurotoxicity (related to the dosing schedule). The schedule was amended to 1,800 mg/m2/day × 5 days with 6 further patients enrolled at dose level #1 and no further reports of neurotoxicity. 3 patients were enrolled at dose level #2 (topotecan: 0.75 mg/m2/day). Results: 14 patients (3-18 yrs) with relapsed/refractory disease and histological verification of their disease at the time of initial diagnosis or relapse were enrolled on this study (Wilms 2; osteosarcoma 2; germ cell tumor 2; high grade glioma 1; rhabdomyosarcoma 1; sarcoma 1; non-Hodgkin's lymphoma 1; neuroblastoma 1; medulloblastoma 1; hepatoblastoma 1; neurocytoma 1). Overall, 2 DLT's (dose level #1: hematologic; dose level #2: hematologic and infection) were observed with a median of 3 cycles being administered (range: 1-3). Disease response showed 4/14 with CR, 2/14 with PR, and 1/14 with SD for an overall response rate (ORR) of 43%. Conclusions: These preliminary results demonstrate that the combination of topotecan, ifosfamide, and carboplatin (TIC) is feasible, induces a ≥40% ORR in relapsed/refractory patients, and warrants further study in children with CNS and solid tumors. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration GlaxoSmithKline
Abstract P269: Predictive Value of Midregional Proadrenomedullin Compared to Natriuretic Peptides for Major Adverse Cardiovascular Events in the Population-Based FINRISK 1997 Cohort
Authors: Anne Funke-Kaiser, Aki S Havulinna, Tanja Zeller, Sebastian Appelbaum, Pekka Jousilahti, Stefan Blankenberg, Karsten Sydow, Veikko Salomaa
Journal: Circulation (2013)

Background and aims: Biomarkers reflecting vascular function and neurohumoral activity may predict cardiovascular disease (CVD). Midregional proadrenomedullin (MR-proADM) is increased in myocardial infarction and correlates with the severity of heart failure (HF).The aim of the present study was to examine the predictive ability of MR-proADM for incident CVD events in a prospective, population-based setting for the first time and to compare the findings on MR-proADM with those of natriuretic peptides. Methods: MR-proADM, B-type natriuretic peptide (BNP), N-terminal pro-BNP (NT-proBNP) and midregional proatrial natriuretic peptide (MR-proANP) were measured from stored samples of the FINRISK 1997 cohort. After excluding individuals with a history of major adverse cardiovascular event (MACE) and pregnant women at baseline, 7,899 individuals were included. The follow-up was until Dec. 31 st , 2010. We used Cox proportional hazards regression to estimate hazard ratios (HR) per one standard deviation increase in each biomarker and for each type of MACE, adjusting for standard CVD risk factors. Measures of discrimination and reclassification were calculated using ten-fold cross-validation. Results: During follow-up 1,074 incident MACE (529 coronary heart disease (CHD) events, 299 ischemic strokes, 505 cases of HF) occured. Adjusted HRs (and 95% confidence intervals) of outcomes for each biomarker are shown in the table. Adding MR-proADM improved discrimination and reclassification for HF (C-index improved from 0.822 to 0.840, NRI was 12.1%, IDI was also significant, all p&lt;0.001), but not for CHD events or stroke. Conclusions: In the general population of the FINRISK 1997 cohort, MR-proADM had no additional predictive effect for CHD events or stroke beyond natriuretic peptides. However, MR-proADM proved to be strongly predictive for incident HF and improved discrimination and reclassification similarly to NT-proBNP while being more specific.
Abstract 4572: Reduced Cardiac Progenitors in the Right Ventricle of Cyanotic Heart Lesions: Insights into RV Adaptation
Authors: Naila Mahmut, Caroline Kinnear, Megan Thompson, Patrick Shannon, David Chitayat, Edgar Jaeggi, Seema Mital
Journal: Circulation (2008)

The RV in hypoplastic left heart syndrome (HLHS) and Tetralogy of Fallot (TOF) is exposed to hypoxia and abnormal load which may lead to RV dysfunction despite surgical repair. The ability of hypoxia to upregulate angiogenic signaling in the RV is not known. We measured vascular endothelial growth factor (VEGF) mediated regulation of cardiac progenitors in the RV of patients with HLHS and TOF. Methods: RV myocardial samples were obtained from 6 pts with HLHS (age 0.96±1.5 yrs), 6 pts with TOF (age 3.5±6.3 yrs) and 9 age-matched controls with structurally normal hearts (age 0.16±0.3 yrs) at surgery/transplant/autopsy. The following were measured: VEGF, thymosin β-4 (recruits progenitors), Nkx2.5 (myocyte precursor), Flk-1 (smooth muscle progenitor), CD34 (endothelial progenitor), and von willebrand factor (vWf) (endothelial marker). Results: (i) VEGF and thymosin β-4 expression was lower in HLHS vs controls. This was associated with reduced cardiac progenitors and lower myocardial capillary density vs controls (0.14±0.01 vs 0.55±0.16, p&lt;0.05). (ii) VEGF expression was preserved but thymosin β-4 was reduced in RV in TOF. This was associated with preserved myocyte progenitors but reduction in endothelial and smooth muscle lineages and reduced capillary density vs controls (0.13±0.03 vs 0.55±0.16, p&lt;0.05) (Figure 1 ). Conclusion: Hypoxia fails to induce an angiogenic response in the RV in cyanotic heart lesions. This may be due to reduced VEGF (HLHS) or impaired coupling of VEGF to thymosin β-4 (TOF). This maladaptation may contribute to post-operative RV dysfunction and lower RV regenerative capacity in later life. Figure 1: Reduced capillary density (red) in HLHS and TOF
Abstract 2257: Cardiac Tissue Explant Culturing: A Novel Method to Study Human Pediatric Injury-Related Cytokine Signaling
Authors: Jasmine Steele, Ann Steele, Peter Steele, William Schleif, Jeffrey Jacobs, Wilfredo Chamizo, Vincent Molnar, Alfred Asante-Korang, Robert J Boucek
Journal: Circulation (2009)

Background. Paracrine functions of the human heart have been postulated to provide important signaling for injury-related regenerative responses associated with cell migration and proliferation. Re...
Burns reconstruction
Authors: Juan P Barret
Journal: BMJ (2004)

The basic concerns in burns reconstruction are for function, comfort, and appearance. Normal and hypertrophic scarring, scar contracture, loss of parts of the body, and change in colour and texture of injured skin are processes common to all seriously burnt patients and yet unique to each. A realistic approach is necessary to harmonise patients' expectations (which are very high) with the probable outcomes of reconstructive surgery. Burn reconstruction starts when a patient is admitted with acute burns and lasts until the patient's expectations have been reached or there is nothing else to offer. However, even when this time has come, the patient-surgeon relationship may still continue and can last a lifetime. Any surgeon undertaking burn reconstruction must have good understanding of wound healing and scar maturation to plan the time of reconstruction, and sound knowledge of all surgical techniques and all the aftercare required (usually in conjunction with a burn team). A strong patient-surgeon relationship is necessary in order to negotiate a master plan and agree on priorities. Definitive correction of burn scarring should generally be delayed for a year or more after scar healing. Unsightly scars mature over time, and, with the help of pressure and splints, many of them do not require surgery once the acute phase of scar maturation is over. Patience is often the best tool of a reconstructive surgeon. However, certain problems must be dealt with before scar maturation is complete. In burn reconstruction there are urgent procedures, others that are essential, and many that are desirable. It is for the last group that a good patient-surgeon relationship is necessary for negotiation on which procedures take priority.
How to write a psychiatric report for litigation following a personal injury
Authors: B F Hoffman
Journal: American Journal of Psychiatry (1986)

Psychiatrists are frequently asked to assess the psychiatric complications of personal injury cases for individuals who are seeking damages from third parties as the result of an accident. A selective review of the literature concerning the etiology and diagnoses applicable to psychiatric morbidity following personal injury is summarized. The author presents one outline of the medical-legal consultation. The reasons for inclusion of each category of information are discussed, and practical suggestions are made on how the data can be interpreted and used to educate the judicial system about the emotional consequences of accidents.
Abstract 3996: Intrinsic Platelet Variability in Response to ADP Before Exposure to Thienopyridines Contributes to the Variability in Residual Platelet Reactivity to ADP After Treatment with Clopidogrel or Prasugrel: Results from PRINCIPLE-TIMI 44
Authors: Andrew L Frelinger, Alan D Michelson, Stephen D Wiviott, Dietmar Trenk, Franz-Josef Neumann, Herz Zentrum, Debra L Miller, Joseph A Jakubowski, Timothy M Costigan, Carolyn H McCabe, Elliott M Antman, Eugene Braunwald
Journal: Circulation (2008)

Background: Variability in residual platelet function following clopidogrel has been well described. In PRINCIPLE-TIMI 44, a randomized study of prasugrel compared with clopidogrel (600 mg load, 15...
Efficacy and Safety of Deferasirox (Exjade®) in Patients with β-Thalassemia Major Treated for up to 5 Years.
Authors: M. Domenica Cappellini, Silverio Perrotta, Leyla Agaoglu, Yesim Aydinok, Marcello Capra, Duran Canatan, Guillermo Drelichman, Yurdanur Kilinc, Carmelo Magnano, John B. Porter, Antonio Piga, Louis Griffel, Darlene Lagrone, Joan Clark, Antonis Kattamis
Journal: Blood (2009)
Clinician Training Reduces Cesarean Rates in Low-Risk Pregnancies
Authors: Anita Slomski
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of progression-free survival (PFS) at 2 or 3 years with overall survival (OS) at 5 years for locally advanced bladder cancer (BC): Evaluation of individual patient data (IPD) from seven randomized trials comparing local therapy with or without neoadjuvant chemotherapy (NC).
Authors: G. J. Chen, G. Sonpavde, C. L. Vale, D. Fisher, T. Powles
Journal: Journal of Clinical Oncology (2011)

4583 Background: We previously identified an association between PFS at 2 years (PFS2) and 3 years (PFS3) with OS at 5 years (OS5) in a multicenter database of patients with locally advanced BC undergoing surgery alone or with adjuvant chemotherapy. We aimed to validate the association using IPD from randomized trials comparing surgery (S) or radiotherapy (XRT) alone or with NC that were included in a meta-analysis conducted by the ABCMAC group. Methods: Kappa (κ) statistics were used to estimate agreement of PFS and OS. Values of κ>0.6 were considered ‘substantial’; κ>0.8 considered ‘almost perfect’. Individual level associations between PFS2 and PFS3 with OS5 were examined using Cox proportional-hazards regression models with all patients censored at 5 years. Results: IPD were available from 7 randomized trials (2,127 patients) that reported both PFS and OS. Overall, the number of patients who progressed or died was 1,129 (53.1%) at 2 years and 1,241 (58.3%) at 3 years. There were 1,306 deaths by 5 years (61.4%). The overall agreement (κ) between PFS2 and OS5 was 0.80 (95% CI: 0.72-0.82), and between PFS3 and OS5 was 0.81 (95% CI: 0.78-0.84) Agreements were similar when analyzed by stage (T2N0 vs. ≥T3-T4N0), with or without NC, and for S or XRT. Those who did not progress by 2 years (median survival 7.59 years, 95% CI: 7.38 – 7.85) or 3 years (median survival 7.64 years, 95% CI=7.42 – 7.91) were more likely to survive to 5 years compared with those who had progressed (HR=1.84 for both PFS2 and PFS3, p<0.0001, 95%CI: 1.50-2.26). Internal validation using the “leave-one-out” method confirmed the association of both PFS2 and PFS3 with OS5 (HRs ranged from 1.23 to 3.97). Conclusions: Analysis of IPD from the meta-analysis database supported individual level associations between both PFS2 and PFS3 and OS5 for patients with locally advanced BC undergoing local therapy with and without NC. These data validate the previously demonstrated association between PFS and OS, which could accelerate the completion of trials of perioperative systemic therapy for BC.
Differential scanning calorimetry of blood plasma for lung cancer diagnosis.
Authors: D. Xiang, N. C. Garbett, J. B. Chaires, G. H. Kloecker
Journal: Journal of Clinical Oncology (2010)

e21085 Background: We have invented a novel assay by using differential scanning calorimetry (DSC) for rapid characterization of the plasma proteome based on the thermal properties of the constituent proteins. Human plasma is a complex fluid that contains more than 3000 individual proteins and peptides in different quantities. DSC is a proven biophysical technique for measuring the energy absorbed by a solution of proteins as a function of temperature. The assay offers an entirely new analytical window into the plasma proteome, and provides a signature calorimetric thermogram that is a unique snapshot of an individual's plasma protein composition. Methods: Plasma samples were collected from lung cancer (LC) patients and healthy volunteers and stored at –70°C. Sample analysis was performed using an automated capillary DSC. Comparison of plasma thermograms from LC patients and controls was done using quantile-quantile plots and the Kolmogorov-Smirnov test. Results: Since our pilot study in 2009, we enrolled 60 LC patients but only analyzed 30 samples for this validation study plus another 109 normal controls. The thermograms from 109 control plasmas were highly reproducible and showed similar characteristic shape without statistical difference from our previous 100 control results. The samples from 30 new LC patients also yielded a unique thermogram differing from that of current and previous controls but similar to the results from 20 previous LC patients in our pilot study in 2009 without statistical difference. Our results further validated our hypothesis that DSC was sensitive to properties of the plasma proteins other than their charge and mass, and changes in thermogram shapes and positions in LC may arise from changes in the concentrations of plasma proteins, from disease-induced protein-protein interactions, or from the secretion into plasma of disease-related peptides or ligands that may bind to the most abundant plasma proteins. Conclusions: Lung cancer may have a characteristic signature thermogram that may serve as a biomarker. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Louisville Biosciences, Inc.
Abstract 12973: Genetic Suppression of Calcium-Dependent Tyrosine Kinase Pyk2 Increases Vulnerability to Ventricular Tachyarrhythmia
Authors: Di Lang, Alexey Glukhov, Katherine Holzem, Tatiana Efimova, Igor Efimov
Journal: Circulation (2010)

Introduction: Proline-rich tyrosine kinase 2 (Pyk2) is a non-receptor protein kinase regulated by intracellular Ca2+, CaMK, and PKC, and can be activated by different stress signals involved in ven...
Abstract 15911: Myocardial Matrix Dysregulation Occurs Early in Infant Right Ventricular Pressure Ovleroad
Authors: Francis X McGowan, Rupak Mukherjee, Patrick Campbell, Ingeborg Friehs, Dimitrios N Poutias, Catalin Baicu, Michael R Zile, Francis Spinale, Huamei He
Journal: Circulation (2011)

Background: Right ventricular failure due to abnormal hemodynamic load is a frequent occurrence and critical determinant of long-term outcome in many forms of congenital heart disease and pulmonary...
Intake of isoflavones-enriched soy product fermented with Enterococcus faecium decrease total and non-HDL cholesterol levels in rats
Authors: Daniela Cardoso Umbelino Cavallini, Elizeu Antonio Rossi, Iracilda Zeppone Carlos, Regina Célia Vendramini, R. C. Damaso, R. Bedani, G. F. Valdez
Journal: Circulation (2008)
Abstract 14526: Matrix Metalloproteinase-28 Deletion Preserves Cardiac Function Following Myocardial Infarction in Mice
Authors: Yonggang Ma, Jianhua Zhang, Anne M Manicone, Merry L Lindsey
Journal: Circulation (2011)

Matrix Metalloproteinase-28 (MMP-28, epilysin) is the newest member of MMP family and is constitutively expressed in multiple normal adult tissues, suggesting a role in tissue homeostasis. Previous...