tbuckley/cabot-search huggingface dataset:
Whole-of-Life Inclusion in Bayesian Adaptive Platform Clinical Trials
Authors: Anita J. Campbell, Keerthi Anpalagan, Emma J. Best, Philip N. Britton, Amanda Gwee, James Hatcher, Brett J. Manley, Julie Marsh, Rachel H. Webb, Joshua S. Davis, Robert K. Mahar, Anna McGlothlin, Brendan McMullan, Michael Meyer, Jocelyn Mora, Srinivas Murthy, Clare Nourse, Jesse Papenburg, Kevin L. Schwartz, Oded Scheuerman, Thomas Snelling, Tobias Strunk, Michael Stark, Lesley Voss, Steven Y. C. Tong, Asha C. Bowen, Zoe McQuilten, Steve Webb, David Paterson, George Heriot, Jason Roberts, Matthew Scarborough, David Lye, Genevieve Walls, Susan Morpeth, Tom Boyles, Marc Bonten, Marjolein P.M Hensgens, Nick Daneman, Dafna Yahav, Anna L Goodman, Matthew Cheng, Catherine Cosgrove, Lynda Whiteway, Sebastian Van Hal, Todd C. Lee, Roger J Lewis, Owen Robinson, Erica Hardy, Isabelle Malhamé
Journal: JAMA Pediatrics (2024)

There is a recognized unmet need for clinical trials to provide evidence-informed care for infants, children and adolescents. This Special Communication outlines the capacity of 3 distinct trial design strategies, sequential, parallel, and a unified adult-pediatric bayesian adaptive design, to incorporate children into clinical trials and transform this current state of evidence inequity. A unified adult-pediatric whole-of-life clinical trial is demonstrated through the Staphylococcus aureus Network Adaptive Platform (SNAP) trial.
Cognition and Return to Work Status 2 Years After Breast Cancer Diagnosis
Authors: Marie Lange, Justine Lequesne, Agnes Dumas, Bénédicte Clin, Ines Vaz-Luis, Barbara Pistilli, Olivier Rigal, Christelle Lévy, Florence Lerebours, Anne-Laure Martin, Sibille Everhard, Gwenn Menvielle, Florence Joly
Journal: JAMA Network Open (2024)

Return to work after breast cancer (BC) treatment depends on several factors, including treatment-related adverse effects. While cancer-related cognitive impairment is frequently reported by patients with BC, to date, no longitudinal studies have assessed its association with return to work.
Modeling Nursing Home Harms From COVID-19 Staff Furlough Policies
Authors: Sarah M. Bartsch, Colleen Weatherwax, Bruce Leff, Michael R. Wasserman, Raveena D. Singh, Kavya Velmurugan, Danielle C. John, Kevin L. Chin, Kelly J. O’Shea, Gabrielle M. Gussin, Marie F. Martinez, Jessie L. Heneghan, Sheryl A. Scannell, Tej D. Shah, Susan S. Huang, Bruce Y. Lee
Journal: JAMA Network Open (2024)

Current guidance to furlough health care staff with mild COVID-19 illness may prevent the spread of COVID-19 but may worsen nursing home staffing shortages as well as health outcomes that are unrelated to COVID-19.
Bleeding in Patients With Atrial Fibrillation—Reply
Authors: Wayne A. Ray, C. Michael Stein, Katherine T. Murray
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Picking Up PrEP—Role of Clinician Specialty
Authors: Meredith Greene, Lona Mody
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Coupon Redemption in a National Sample of Individuals Who Use Tobacco and Nicotine Products
Authors: Eugene M. Talbot, Cristine D. Delnevo, Michelle T. Bover Manderski, Kevin R. J. Schroth, Ollie Ganz
Journal: JAMA Network Open (2024)

This cross-sectional study investigates coupon redemption in a national sample of US adults who used tobacco and nicotine in the past 30 days.
Further Study Needed on Antihypertensive Medications and Fracture Risks
Authors: Chia-Ter Chao
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Tranexamic Acid in Patients Undergoing Liver Resection
Authors: Paul J. Karanicolas, Yulia Lin, Stuart A. McCluskey, Jordan Tarshis, Kevin E. Thorpe, Alice Wei, Elijah Dixon, Geoff Porter, Prosanto Chaudhury, Sulaiman Nanji, Leyo Ruo, Melanie E. Tsang, Anton Skaro, Gareth Eeson, Sean Cleary, Carol-Anne Moulton, Chad G. Ball, Julie Hallet, Natalie Coburn, Pablo E. Serrano, Shiva Jayaraman, Calvin Law, Ved Tandan, Gonzalo Sapisochin, David Nagorney, Douglas Quan, Rory Smoot, Steven Gallinger, Peter Metrakos, Trevor W. Reichman, Diederick Jalink, Sean Bennett, Francis Sutherland, Edward Solano, Michele Molinari, Ephraim S. Tang, Susanne G. Warner, Oliver F. Bathe, Jeffrey Barkun, Michael L. Kendrick, Mark Truty, Rachel Roke, Grace Xu, Myriam Lafreniere-Roula, Gordon Guyatt
Journal: JAMA (2024)

Tranexamic acid reduces bleeding and blood transfusion in many types of surgery, but its effect in patients undergoing liver resection for a cancer-related indication remains unclear.
Further Study Needed on Antihypertensive Medications and Fracture Risks
Authors: Chee H. Liew
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Trends in Mortality After Incident Hospitalization for Heart Failure Among Medicare Beneficiaries
Authors: Adam S. Vohra, Ali Moghtaderi, Qian Luo, David J. Magid, Bernard Black, Frederick A. Masoudi, Vinay Kini
Journal: JAMA Network Open (2024)

Despite advances in treatment and care quality for patients hospitalized with heart failure (HF), minimal improvement in mortality has been observed after HF hospitalization since 2010.
<i>JAMA Neurology</i> Editorial Fellowship—Call for Applicants
Authors: S. Andrew Josephson
Journal: JAMA Neurology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Machine Learning Prediction of Autism Spectrum Disorder From a Minimal Set of Medical and Background Information
Authors: Shyam Sundar Rajagopalan, Yali Zhang, Ashraf Yahia, Kristiina Tammimies
Journal: JAMA Network Open (2024)

Early identification of the likelihood of autism spectrum disorder (ASD) using minimal information is crucial for early diagnosis and intervention, which can affect developmental outcomes.
Astrocyte Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice
Authors: Joselyn S Soto, Chiranjivi Neupane, Muskan Kaur, Vijaya Pandey, James A Wohlschlegel, Baljit S Khakh
Journal: Neuron (2024)

Astrocytes are morphologically complex cells that serve essential roles. They are widely implicated in central nervous system (CNS) disorders, with changes in astrocyte morphology and gene expression accompanying disease. In the Sapap3 knockout (KO) mouse model of compulsive and anxiety-related behaviors related to obsessive-compulsive disorder (OCD), striatal astrocytes display reduced morphology and altered actin cytoskeleton and Gi-G-protein-coupled receptor (Gi-GPCR) signaling proteins. Here, we show that normalizing striatal astrocyte morphology, actin cytoskeleton, and essential homeostatic support functions by targeting the astrocyte Gi-GPCR pathway using chemogenetics corrected phenotypes in Sapap3 KO mice, including anxiety-related and compulsive behaviors. Our data portend an astrocytic pharmacological strategy for rescuing phenotypes in brain disorders that include compromised astrocyte morphology and tissue support.
Overall Survival, Treatment Duration, and Rechallenge Outcomes With ICI Therapy for Recurrent or Metastatic HNSCC
Authors: Lova Sun, Roger B. Cohen, Christopher A. D’Avella, Aditi P. Singh, Jonathan D. Schoenfeld, Glenn J. Hanna
Journal: JAMA Network Open (2024)

Immune checkpoint inhibition (ICI) is a frontline treatment for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC), but questions remain surrounding optimal duration of therapy, benefits and risks of ICI rechallenge, and efficacy in first vs subsequent lines of therapy.
Expanding the Prion Paradigm to Include Alzheimer and Parkinson Diseases
Authors: Carlo Condello, David Westaway, Stanley B. Prusiner
Journal: JAMA Neurology (2024)

This Viewpoint describes the evidence for iatrogenic disease based on amyloid-β prions and the possibility that Alzheimer disease has an iatrogenic form wherein amyloid β and tau behave as prions that transmit the disease.
Treatment of Transcatheter Aortic Valve Thrombosis
Authors: Rik Adrichem, Josep Rodes Cabau, Roxana Mehran, Duk-Woo Park, Jurrien M Ten Berg, Ole de Backer, Christian Hengstenberg, Ricardo P J Budde, George D Dangas, Raj Makkar, Nicolas M Van Mieghem
Journal: Journal of the American College of Cardiology (2024)
Deep Learning-Based Electrocardiogram Analysis Predicts Biventricular Dysfunction and Dilation in Congenital Heart Disease
Authors: Joshua Mayourian, Addison Gearhart, William G La Cava, Akhil Vaid, Girish N Nadkarni, John K Triedman, Andrew J Powell, Rachel M Wald, Anne Marie Valente, Tal Geva, Son Q Duong, Sunil J Ghelani
Journal: Journal of the American College of Cardiology (2024)
Incidence and Survival Outcomes of Gastrointestinal Stromal Tumors
Authors: Christian S. Alvarez, M. Blanca Piazuelo, Tania Fleitas-Kanonnikoff, Jennifer Ruhl, J. Alejandro Pérez-Fidalgo, M. Constanza Camargo
Journal: JAMA Network Open (2024)

The incidence of gastrointestinal stromal tumors (GISTs) increased after the implementation of GIST-specific histology coding in 2001, but updated data on trends and survival are lacking.
Nursing Team Composition and Mortality Following Acute Hospital Admission
Authors: Peter Griffiths, Christina Saville, Jane Ball, David Culliford, Jeremy Jones, Francesca Lambert, Paul Meredith, Bruna Rubbo, Lesley Turner, Chiara Dall’ora, Andrew Barraclough, Chris Bojke, Louise Bramley, Greg Bull, Lara Carmona, Andy Charlwood, Jonathan Drennan, Jo Fillingham, Liam Flynn, Fiona Hyett, Oliver Redfern, Liz Rix, Paul Scmidt, Dave Shields, Carol Stiles, Karen Swinson, Rachel Taylor, Neil Tape
Journal: JAMA Network Open (2024)

Many studies show the adverse consequences of insufficient nurse staffing in hospitals, but safe and effective staffing is unlikely to be just about staff numbers. There are considerable areas of uncertainty, including whether temporary staff can safely make up shortfalls in permanent staff and whether using experienced staff can mitigate the effect of staff shortages.
An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies
Authors: Yiquan Wang, Huibin Lv, Qi Wen Teo, Ruipeng Lei, Akshita B Gopal, Wenhao O Ouyang, Yuen-Hei Yeung, Timothy J C Tan, Danbi Choi, Ivana R Shen, Xin Chen, Claire S Graham, Nicholas C Wu
Journal: Immunity (2024)
Further Study Needed on Antihypertensive Medications and Fracture Risks—In Reply
Authors: Chintan V. Dave, Michelle C. Odden
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches
Authors: Jiajia Tang, Quan Zheng, Qi Wang, Yaru Zhao, Preeta Ananthanarayanan, Chiara Reina, Berina Šabanović, Ke Jiang, Ming-Hsin Yang, Clara Csilla Meny, Huimin Wang, Mette Ø. Agerbaek, Thomas Mandel Clausen, Tobias Gustavsson, Chenlei Wen, Felice Borghi, Alfredo Mellano, Elisabetta Fenocchio, Vanesa Gregorc, Anna Sapino, Thor G. Theander, Da Fu, Alexandra Aicher, Ali Salanti, Baiyong Shen, Christopher Heeschen
Journal: Cell Reports Medicine (2024)

Pancreatic ductal adenocarcinoma (PDAC) poses significant clinical challenges, often presenting as unresectable with limited biopsy options. Here, we show that circulating tumor cells (CTCs) offer a promising alternative, serving as a "liquid biopsy" that enables the generation of in vitro 3D models and highly aggressive in vivo models for functional and molecular studies in advanced PDAC. Within the retrieved CTC pool (median 65 CTCs/5 mL), we identify a subset (median content 8.9%) of CXCR4
GABA Analogue HSK16149 in Chinese Patients With Diabetic Peripheral Neuropathic Pain
Authors: Xiaohui Guo, Tingting Zhang, Geheng Yuan, Weifang Zeng, Qingyuan Hu, Jianhua Ma, Yukun Li, Hongmei Li, Yawei Zhang, Jie Liu, Fang Bian, Wei Zhang, Fang Zhang, Shuguang Pang, Ya Li, Xiaohong Wu, Xulei Tang, Keqin Zhang, Tianrong Pan, Honglin Hu, Zhifeng Cheng, Yanjun Wang, Jialin Gao, Jia Sun
Journal: JAMA Network Open (2024)

Many patients with diabetic peripheral neuropathic pain (DPNP) experience inadequate relief, despite best available medical treatments. There are no approved and effective therapies for patients with DPNP in China.
Bleeding in Patients With Atrial Fibrillation
Authors: Bethany T. Samuelson Bannow, Alyssa Colwill, Alison Edelman
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Off-Treatment Effects of Olpasiran on Lipoprotein(a) Lowering
Authors: Michelle L O'Donoghue, Robert S Rosenson, J Antonio G López, Norman E Lepor, Seth J Baum, Elmer Stout, Daniel Gaudet, Beat Knusel, Julia F Kuder, Sabina A Murphy, Huei Wang, You Wu, Trupti Shah, Jingying Wang, Tomasz Wilmanski, Winnie Sohn, Helina Kassahun, Marc S Sabatine
Journal: Journal of the American College of Cardiology (2024)

Olpasiran, a small interfering RNA (siRNA), blocks lipoprotein(a) (Lp(a)) production by preventing translation of apolipoprotein(a) mRNA. In phase 2, higher doses of olpasiran every 12 weeks (Q12W) reduced circulating Lp(a) by >95%.
Effect of Semaglutide on Epicardial Adipose Tissue in Type 2 Diabetes
Authors: Venkat Sanjay Manubolu, Suvasini Lakshmanan, April Kinninger, Khadije Ahmad, Shriraj Susarla, Hoon J Seok, Sajad Hamal, Suraj Dahal, Sion K Roy, Matthew J Budoff
Journal: Journal of the American College of Cardiology (2024)
A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids: Application to endogenous regeneration of articular cartilage
Authors: Liwei Fu, Jiang Wu, Pinxue Li, Yazhe Zheng, Zhichao Zhang, Xun Yuan, Zhengang Ding, Chao Ning, Xiang Sui, Shuyun Liu, Sirong Shi, Quanyi Guo, Yunfeng Lin
Journal: Bioactive Materials (2024)

Articular cartilage injury (ACI) remains one of the key challenges in regenerative medicine, as current treatment strategies do not result in ideal regeneration of hyaline-like cartilage. Enhancing endogenous repair via microRNAs (miRNAs) shows promise as a regenerative therapy. miRNA-140 and miRNA-455 are two key and promising candidates for regulating the chondrogenic differentiation of mesenchymal stem cells (MSCs). In this study, we innovatively synthesized a multifunctional tetrahedral framework in which a nucleic acid (tFNA)-based targeting miRNA codelivery system, named A-T-M, was used. With tFNAs as vehicles, miR-140 and miR-455 were connected to and modified on tFNAs, while Apt19S (a DNA aptamer targeting MSCs) was directly integrated into the nanocomplex. The relevant results showed that A-T-M efficiently delivered miR-140 and miR-455 into MSCs and subsequently regulated MSC chondrogenic differentiation through corresponding mechanisms. Interestingly, a synergistic effect between miR-140 and miR-455 was revealed. Furthermore, A-T-M successfully enhanced the endogenous repair capacity of articular cartilage in vivo and effectively inhibited hypertrophic chondrocyte formation. A-T-M provides a new perspective and strategy for the regeneration of articular cartilage, showing strong clinical application value in the future treatment of ACI.
Pediatric Inpatient Psychiatric Capacity in the US, 2017 to 2020
Authors: Anna M. Cushing, Katherine A. Nash, Ashley A. Foster, Bonnie T. Zima, Amy E. West, Kenneth A. Michelson, Jennifer A. Hoffmann
Journal: JAMA Pediatrics (2024)

This cross-sectional study assesses US pediatric inpatient psychiatric capacity and identifies state-level variation in access to pediatric inpatient psychiatric beds.