tbuckley/cabot-search huggingface dataset:
Vorinostat in combination with bexarotene in advanced cutaneous T-cell lymphoma: A phase I study
Authors: R. Dummer, K. Hymes, W. Sterry, M. Steinhoff, C. Assaf, H. Kerl, J. Ahern, S. Rizvi, J. L. Ricker, S. Whittaker
Journal: Journal of Clinical Oncology (2009)

8572 Background: Vorinostat, a histone deacetylase inhibitor, is registered for the treatment of advanced cutaneous T-cell lymphoma (CTCL) in the US. Preclinical studies suggest that vorinostat may enhance the activity of chemotherapeutic or biological anticancer agents in a variety of cancers. This Phase I, multicenter, open-label study systematically evaluated vorinostat combined with the retinoid bexarotene in patients (pts) with advanced CTCL. Methods: Eligible pts were aged ≥18 years with stage ≥IB progressive, persistent, or recurrent CTCL refractory to ≥1 systemic therapy. Primary objective was to determine the maximum tolerated dose (MTD). Phase Ia Part I: dose escalation of vorinostat (200–400 mg/day) and bexarotene (150–300 mg/m 2 /day); Part II: fixed vorinostat dose (400 mg/day) with bexarotene dose escalation (150–450 mg/day). Cycles were repeated every 28 days for ≤6 cycles. Clinical activity and safety of the combination was also assessed. Results: 23 pts received ≥1 dose of study medication. Three pts in dose level (DL) 2 experienced dose-limiting toxicities (DLTs) ( Table ). No DLTs were observed in the first cycle of DL 2a and 2b. The MTD (Part I) was vorinostat 200 mg/day plus bexarotene 300 mg/m 2 /day. The Part II MTD was not reached as the study was discontinued early due to low enrollment; no DLTs were observed at DL 6 or 7. The most common drug-related adverse events (DRAEs) were hypothyroidism (35%), fatigue (30%), and hypertriglyceridemia (30%). No Grade 4 or 5 DRAEs were reported and 4 pts had serious DRAEs (Grade ≤3). Eighteen pts have discontinued: 5 due to AEs, 5 due to progressive disease, and 8 withdrew consent. Of 22 pts evaluable for efficacy, 4 (18%) had an objective response, and 7 (32%) derived clinical benefit (pruritis relief). Conclusions: These preliminary data suggest that the vorinostat/bexarotene combination is feasible in pts with advanced CTCL; however, the dosage of either drug must be reduced to avoid unacceptable side effects. [Table: see text] [Table: see text]
Some Additive Effects of Carcinogenic Hydrocarbons
Authors: P. S. Lavik, P. R. Moore, H. P. Rusch, C. A. Baumann
Journal: Cancer Research (1942)

Table I contains a summary of all experiments in which solutions of 20-methylcholanthrene were applied to the backs of ,nice for 2 months. At the end of this period 2 out of 282 mice on the control diet when tumors developed in 2 of io mice which were painted with 3,4-benzpyrene for 8 weeks, followed by similar treatment with ~,2,5,6-dibenzanthracene. Each treatment by itself failed to produce tumors. In view of these fragmentary data we have studied the additive effects of hydrocarbons in some detail. In a preliminary experiment 2o heterozygous albino mice were painted on the interscapular region with a 0.2 per cent solution of methylcholanthrene in dioxane twice weekly for 21//_9 months. A comparable group of animals was painted with methylcholanthrene during the Ist month, with a o.2 per cent solution of
Short-term (ST) versus long-term (LT) hormone treatment (HT) in combination with radiotherapy (RT) for locally advanced prostate cancer (LAPC): Meta-analysis of randomized trials (RCTs)
Authors: F. Cuppone, E. Bria, D. Giannarelli, M. Milella, E. M. Ruggeri, I. Sperduti, C. Nisticò, E. Terzoli, F. Cognetti, P. Carlini
Journal: Journal of Clinical Oncology (2009)

5128 Background: Hormone suppression plus RT is able to significantly decrease the recurrences and the mortality of patients (pts) affected by LAPC. In order to determine if difference exists between ST-HT (HT ≤6 months), and LT-HT (HT ≥8 months) in combination with RT for LAPC, a literature-based meta-analysis was conducted. Methods: Event-based relative risks (RR) with 95% confidence intervals (CI) were derived through a random-effect model. Differences in primary (biochemical failure, BF, and cancer-specific survival, CSS), and secondary outcomes (overall survival, OS, and pattern of recurrence, local or distant, LR/DM) were explored. Absolute differences (AD) and the number of patients needed to treat (NNT) were calculated. Heterogeneity test, a meta-regression analysis with clinico-pathological predictors for outcomes and a correlation analysis for surrogate end-points were conducted as well. Results: Four trials (3,148 patients) were gathered. Data were available for all RCTs only for BF; patient population ranged from 297 to 1,521 pts. Three predictors were identified: median PSA (range 9.5–20.35), Gleason score 7–10 (27–55% pts/trial) and T3–4 (13–77% pts/trial). None of the selected predictors did significantly affect any outcomes. A significant correlation and trend between the log of the BF-RR and DM and OS were found (p=0.029 and p=0.07, respectively). Conclusions: Although with significant heterogeneity (reflecting different patient’ risk stratifications), LT-HT seems to significantly decrease biochemical, local and distant recurrences, and increase cancer specific survival in comparison with ST-HT. Balancing these advantages with toxicities and costs represents the next step of the current analysis. [Table: see text] No significant financial relationships to disclose.
Abstract 2334: KChIP2 Functions as a Chaperone, Not as an Accessory Subunit, to Regulate Functional Cell Surface Expression of Kv4-Encoded Myocardial Ito Channels
Authors: Nicholas C Foeger, Jeanne M Nerbonne
Journal: Circulation (2009)

Background: The fast transient K+ current (Ito,f) determines phase 1 repolarization and underlies the physiologic gradient of ventricular repolarization. Ito,f down regulation is prevalent in the h...
Abstract 119: Over-the-Counter Automated External Defibrillators in Homes: Safe and Effective
Authors: Dawn B Jorgenson, Roger D White, P.Y. Liu, Tamara B Yount, Lance B Becker
Journal: Circulation (2010)

Objective: In 2004, the FDA allowed the sale of Philips HeartStart automated external defibrillators (AEDs), a class III medical device previously available for purchase only with a prescription, f...
Abstract 16231: Comparative Long-Term Risk of Death and End-Stage Renal Disease (ESRD) in Medicare Patients With Chronic Kidney Disease Undergoing Coronary Revascularization With Coronary Artery Bypass Surgery versus Percutaneous Coronary Intervention
Authors: Charles A Herzog, David Charytan, Shuling Li
Journal: Circulation (2011)

Introduction/Methods: There are few published data on the comparative long-term risk of developing End-Stage Renal Disease (ESRD) after coronary artery bypass surgery (CAB) vs percutaneous coronary intervention (PCI) in pts with chronic kidney disease (CKD). Using the Medicare 5% Database, we identified 4547 CKD pts having CAB and 8620 with PCI (age 66+ yrs, ESRD excluded) in 2001-2007. Event-free survival for death, ESRD and the combined event of ESRD or death was estimated by Kaplan-Meier method and independent predictors of death or ESRD were examined in a comorbidity-adjusted Cox model. Results: The CAB pts were 67% male, 89% white, 53% age 75+, 82% 3+ arteries bypassed, 16% were “Off-Pump,” PCI pts were 56% male, 87% white, 60% age 75+. 77% 1-vessel PCI, 48% bare metal stent (BMS), 42% drug-eluting stent (DES), 10% percutaneous transluminal coronary angioplasty (PTCA). In-hospital death was 7.1% for CAB and 3.9% for PCI. Risk of ESRD for Off-Pump CAB (vs on-Pump CAB) was not significant: HR (0.96 (0....
Abstract 1535: Lifelong Exercise Training Demonstrates a Dose Dependent Effect on Left Ventricular Compliance and Distensibility
Authors: Paul S Bhella, Shigeki Shibata, Jeffery L Hastings, Anand Prasad, Armin Arbab-Zadeh, Nicole Minniefield, M. D Palmer, James McLoughlin, Daniel Creson, Benjamin D Levine
Journal: Circulation (2009)

Background: Sedentary aging leads to decreases in left ventricular (LV) chamber compliance and distensibility. Conversely, Masters’ athletes who train 6 –7 sessions per week throughout their adult lives maintain youthful LV compliance and distensibility ( Circulation . 2004 ; 110 : 1799 –1805 ). We hypothesized that preservation of compliance during aging may be possible with less rigorous training. Methods: Men &gt; age 65 (n=35) were recruited from: the Aerobics Center Longitudinal Study, a well validated study which has prospectively documented lifelong exercise training patterns in subjects for the past 25 years, regional road-race results and US Masters competitions. Subjects were stratified into ‘Quads’ based on their history of exercise training: Quad 1 (Q1) &lt;2 sessions/wk (n=7); Q2=2–3/wk (n=5); Q3=4 –5/wk (n=11); Q4=6 –7/wk plus regular competitions (n=12). All subjects underwent simultaneous right heart catheterization and transthoracic echo to define LV pressure-volume curves. PCWP and LVEDV were measured at baseline, during decreased cardiac filling by lower-body negative pressure (−15 and −30 mm Hg) and after saline infusion (15 and 30 mL/kg). Results: The pressure volume relationships are presented in Figure 1 . Thick lines=Quad pressure-volume relationships; thin lines=95% confidence intervals. Quad mean peak VO2±S.D. is also reported. Conclusion: Lifelong exercise training has a dose-dependent effect on left ventricular chamber compliance and distensibility. Based on these findings, increasing levels of prolonged, sustained endurance training improve diastolic function and may help to prevent heart failure in the elderly.
Tourette syndrome, pimozide, and school phobia: the neuroleptic separation anxiety syndrome
Authors: L S Linet
Journal: American Journal of Psychiatry (1985)

The development of school phobia has been reported in some patients with Tourette syndrome treated with haloperidol. The author reports on a patient who developed school phobia on each of three trials with pimozide, a neuroleptic chemically similar to haloperidol, and proposes the term "neuroleptic separation anxiety syndrome." The syndrome is clinically indistinguishable from DSM-III criteria for school phobia (separation anxiety disorder). Tricyclic antidepressants may have a therapeutic or prophylactic effect. It is not known whether this neuroleptic side effect occurs in patients other than those with Tourette syndrome.
"DRUGS THAT ENSLAVE."
Authors: Harry Hubbell Kane
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Text-Book of Medical and Pharmaceutical Chemistry.
Authors: Elias H. Bartley
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Moral Dilemmas in Modern Medicine.
Authors: Michael Lockwood
Journal: Annals of Internal Medicine (1987)

Philosophical idealism may not be especially popular today, but I consider Michael Lockwood to be an ideal philosopher: he is bright, articulate and pains- takingly devoted to assisting his audience, whether composed of professional philosophers, medical doctors, or a group just off the proverbial Clapham omnibus, in understanding his philosophical positions regarding medical ethics and how they relate to others.This edited volume, which includes two of Lockwood's own contributions -'When does a life begin?' and 'The Warnock Report.a philosophical appraisal' -offers an excellent read on current prob- lems in medical ethics.The other contributors should be considered household, if not hospital, names: Ian Kennedy on 'The doctor, the pill, and the fifteenyear-old girl: a case study in medical ethics and law'; R M Hare on 'Little human guinea-pigs?';J A Muir Gray on 'The ethics of compulsory removal'; Raanan Gillon on 'Autonomy and consent'; Bernard Williams on 'Which slopes are slippery?';Mary Warnock on 'The artificial family'; and Roger Higgs on 'Telling patients the truth'.Space constraints prohibit closer examination of the articles.But medical practitioners would find the contents of this book stimulating for a discussion group with other colleagues.With the extensive notes, bibliography and glossary provided, the reader, however new to the field ofmedical ethics and however he or she once contemplated dilemmas, will find much to consider in these pages.In short, both angels and medics need not fear to tread through the philosophical arguments, thanks to Lockwood's excellent editing of the book.
Organic Arsenical Compounds.
Authors: Raiziss, George W., b., Joseph L. Gavron
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
National screening programme for diabetic retinopathy
Authors: C. Clements
Journal: BMJ (2002)

Editor—I work as an ophthalmic photographer, but I have no involvement in screening. Prasad et al assert that screening for diabetic retinopathy by optometrists is superior to photographic screening.1 This is questionable for several reasons.

Firstly, biomicroscopy detects macular oedema, and more of the retina can be examined. Both are true, but macular oedema will be accompanied by reduced visual acuity, which is easily measured. Treatable retinopathy is most likely to be found around the posterior pole. Is there an obvious advantage in examining the periphery?

Secondly, photography has a high technical failure rate compared with ophthalmology. Careful reading of the paper cited as evidence for this does not give a failure rate for photography of 14%. Of 326 patients, six were ungradable by any means. Twelve of the remaining 320 patients could not be photographed because of posture or tremor. A further 34 patients were ungradeable; 18 of them had opacities preventing photography. True failure rate is not 46 out of 320 (14%) but 16 out of 320 (5%). Prasad et al have added the 12 patients who had posture and tremor difficulties to the 34 who had ungradeable pictures, giving 46 out of 320. Failures were 46 minus 30, equivalent to 16 out of 320, or 5%. A single technique of examination is not appropriate for all patients, and recording a technical failure when it is impossible for the technique to succeed results in a distortion of the facts.

Thirdly, the choice of digital photography for ease of audit remains valid. Digital photography will improve on the 5% of technical failures because of instant repeatability.

Fourthly, training will be required for optometrists and technicians. Optometrists are familiar with the slit lamp but will need the skills to examine the fundus with appropriate lenses. How will their competence be assessed and monitored? Training technicians to obtain good quality digital images is less challenging than learning slit lamp biomicroscopy. Validation is easier, and performance can be monitored by the screening centre.

Further advantages of digital imaging should not be overlooked.

Firstly, electronic transmission to remotely located reading centres is practical.

Secondly, the development of automated grading software will make a big difference to the grading workload.

Thirdly, digital imaging presents a valuable opportunity for patient education and motivation.

Optometrists can certainly screen, but a digital image offers important advantages. If obtaining a good image is impossible referral is probably required anyway.
Abstract 10006: Remnant Lipoproteinemia is a Risk of Non-Culprit Attenuated Coronary Plaques Detected by Grayscale Intravascular Ultrasound in Patients with Acute Coronary Syndromes
Authors: Jyun-Ei Obata, Yoshinobu Kitta, Yukio Saito, Takamitsu Nakamura, Keita Sano, Daisuke Fujioka, Juntaro Deyama, Manabu Uematsu, Ken-ichi Kawabata, Kiyotaka Kugiyama
Journal: Circulation (2011)

Patients with acute coronary syndromes (ACS) have vulnerable coronary plaques not only in the culprit lesion, but also in non-culprit lesions. The attenuated coronary plaques (hypoechoic plaque wit...
NEW LEGISLATION TO CURB DRINKING DRIVERS
Authors: D Gloag
Journal: BMJ (1989)

This short article describes the contents of a private members bill (the road traffic (breath tests) bill) that clarifies police powers to administer breath tests and introduces powers to establish roadside checkpoints for testing all drivers. The bill contains two clauses. Clause one redefines and clarifies the power of the police officer to stop a vehicle to establish suspicion that its driver is affected by alcohol, in connection with the power to administer breath tests. Clause 2 enables the Secretary of State to make regulations about roadside checkpoints for administrating breath tests to motorists selected at random subject to approriate safeguards. (TRRL)
Familial gastrointestinal stromal tumor with homo-/hemizygous kit exon 11 deletion: Genotypic, histopathologic, radiographic, and therapeutic findings
Authors: E. P. Kleinbaum, L. L. Chen, A. Lazar, L. Strong, W. Zhang, H. Choi, R. Benjamin, S. Patel, J. C. Trent
Journal: Journal of Clinical Oncology (2006)

9527 Background: Germ-line mutations in the kit receptor tyrosine kinase gene have been described in families with a propensity to develop gastrointestinal stromal tumor (GIST). We describe a large kindred with multiple individuals with GIST and describe the genotype, clinical presentation, radiographic imaging, surgical findings, imatinib-sensitivity, and histopathologic appearance. Patients and Methods: A large kindred with multiple GISTs were identified after the proband patient was referred to our institution. The history of each affected and unaffected family member was obtained in person or via telephone. A medical questionnaire was sent to family members and appropriate medical records, tumor tissue and radiographic imaging was obtained. Histopathologic specimens from four of the family members with GIST was obtained, the diagnosis confirmed and three specimens were used to sequence kit exon 9, 11, 13, 15 and 17. Results: Fifteen members were identified in this family with histopathologic diagnosis of GIST or probable GIST. Surgical findings revealed multiple tumors arising from the submucosa of the small intestine. Histopathology revealed microscopic proliferation of the myenteric plexus with areas of microscopic tumor nodularity. Four patients in this kindred were treated with imatinib and had radiographic and clinical evidence of therapeutic benefit. A deletion of codon 579 in exon 11 of the kit gene was identified in tumor and normal tissue of this family. Evaluation of one GIST revealed loss of heterozygosity in kit exon 11 suggesting a homozygous mutation or loss of the wild-type locus. Conclusion: This study describes a kindred with a propensity to develop GIST in association with hyperpigmentation and melanocytic nevi, but not dysphagia. The germline deletion of codon 579 appears to confer proliferation and nodularity of the myenteric plexus, synchronous tumors at presentation, a metastatic phenotype, and in vivo sensitivivity to imatinib therapy. No significant financial relationships to disclose.
La transfusion du sang de cadavre à l'homme.
Authors: Serge Judine, A. Gosset
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal