tbuckley/cabot-search huggingface dataset:
BMJ introduces a fast track system for papers
Authors: S. Goldbeck-Wood, R. Robinson
Journal: BMJ (1999)

Each year when we revisit the BMJ' s mission and strategy, we aim to improve our services to readers, contributors, and reviewers. One step we believe will help is to introduce a formal “fast track” system for urgent or important papers. Our new fast track system begins today. We hope it will attract researchers with high quality studies to submit them to the BMJ , and we hope it will serve readers by helping us to attract better papers. But because fast tracking a paper is demanding of editorial and reviewers' time, we will focus the service on a very small number of papers.

From now on we will be able to offer publication of a paper which meets our criteria for fast track review within four weeks of its registration in our office. In the past we have resisted the idea of fast track publication, because we believe all papers we publish are important or interesting and we feared that the time and attention consumed by a minority of fast track papers …
بحث عن الأسباب الجينية وراء مرض نقص المغنيسيوم مع التكلس الكلوي في الأطفال CLDN16 genotype predicts renal decline in familial hypomagnesemia with hypercalciuria and nephrocalcinosis.
Authors: جميلة قاري
Journal: Journal of the American Society of Nephrology (2008)

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive tubular disorder caused by CLDN16 mutations. CLDN16 encodes the renal tight junction protein claudin-16, which is important for the paracellular reabsorption of calcium and magnesium in the thick ascending limb of Henle’s loop. That FHHNC is frequently associated with progressive renal failure
suggests additional roles for claudin-16 in the maintenance of tight junction integrity. An investigation of 32 patients with FHHNC and 17 different mutations was previously reported; here, the analysis is expanded to 39 additional patients and 12 new mutations. Expression studies revealed that five of the12 new mutations led to partial loss of claudin-16 function and the remaining seven led to complete loss
of function. The 23 patients who had mutations resulting in complete loss of function of both alleles were significantly younger at the onset of symptoms than the 46 patients who had at least one mutant allele providing partial function (2.2 versus 5.6 years; P _ 0.01). In addition, those with complete loss of function had a more rapid decline in GFR (7.3 versus 2.9 ml/min per 1.72 m2/y; P _ 0.01), leading to 54%
requiring renal replacement therapy by age 15 compared with 20% of those with residual function (P _0.05). These data suggest that residual function of claudin-16 may delay the progression of renal failure in FHHN
Characteristics of Mesenchymal Multipotent Stromal Cells Determine Their Effectiveness for Acute Graft Versus Host Disease Prophylaxis after Allogeneic Bone Marrow Transplantation
Authors: Irina N. Shipounova, Natalia Petinati, Alexey Bigildeev, Natalia Sats, Nina I. Drize, Larisa A Kuzmina, Elena N. Parovichnikova, Valeri G. Savchenko
Journal: Blood (2014)
How to Obtain More Autopsies
Authors: D. Schuyler Pulford
Journal: Annals of Internal Medicine (1932)

Article1 April 1932How to Obtain More AutopsiesD. SCHUYLER PULFORD, M.D., F.A.C.P.D. SCHUYLER PULFORD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-10-1315 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThat the percentage of autopsies obtained in any hospital or community is in direct proportion to the interest and efforts of the physicians in getting post mortems, is proven by numerous experiences. Some institutions and teaching hospitals have an average of eighty per cent, or more. In most city hospitals permits are exceedingly low, say from five per cent to twenty per cent.Justifiable pride in ninety per cent autopsies obtained at the Woodland Clinic, for institutional deaths during 1930, and a belief that a discussion of the methods used in obtaining such a high percentage of necropsies will be...References1 Annual presentation of educational data for 1930 by the Council on Medical Education and Hospitals, Jr. Am. Med. Assoc., 1930, xcv, 487-534. Google Scholar2 Sixth annual presentation of hospital data by the Council on Medical Education and Hospitals of the American Medical Association, Jr. Am. Med. Assoc., 1927, lxxxviii, 789-839. Google Scholar3 CHRISTIAN HA: Selecting a hospital for an interneship, Jr. Am. Med. Assoc., 1926, lxxxvi, 1499-1501. CrossrefGoogle Scholar4 RICHARDS LG: Hospital and its necropsy percent, Jr. Am. Med. Assoc., 1928, xc, 896. Google Scholar5 BELL ET: Circumstances that influence the obtaining of necropsies, Jr. Am. Med. Assoc., 1928, xc, 896. CrossrefGoogle Scholar6 KINGSFORD HN: A review of one year's autopsy service, New Hamp. Med. Jr., 1929, cci, 1143-1144. Google Scholar7 ROBERTSON HE: Post mortem examinations and graduate medical instruction, Jr. Assoc. Am. Med. Coll., 1930, v, 216-221. CrossrefGoogle Scholar8 BOGEN E: I want a postmortem made when I die, Hygeia, 1926, iv, 696. Google Scholar9 MILLS RG: Means of securing post mortem examinations, Bull. Am. Coll. Surg., 1930, xiv, 40-57. Google Scholar10 SCHULTZ OT: The law of the dead human body, Arch. Path., 1930, ix, 1220-1241. Google Scholar11 TURNER J: Analyzing the cost of postmortem examination, Mod. Hosp., 1930, xxxv, 69-70. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Woodland, California*From the Department of Medicine and Pathology, Woodland Clinic, Woodland, California.Received for publication, November 18, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1932Volume 5, Issue 10Page: 1315-1320KeywordsAutopsy ePublished: 1 December 2008 Issue Published: 1 April 1932 PDF downloadLoading ...
Abstract 4284: An Expansible Aortic Ring For A Physiological Approach Of Aortic Valve Repair
Authors: Emmanuel Lansac, Isabelle Di Centa, Francois Raoux, Neil Bulman-Fleming, Adrian Ranga, Aicha Abed, Maguette Ba, Anthony Paolitto, Didier Letourneur, Anne Meddahi Pelle
Journal: Circulation (2008)

Objectives: Dystrophic aortic insufficiency is characterized by dilatation of the aortic annular base and sinotubular junction (STJ) diameters with thin and pliable cusps amenable to valve repair. ...
Public Health Organization in the Chicago Region.
Authors: Robert F. Steadman
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Observations of differences in laterality imbalance of breast biopsies and breast disease between Caucasian and African American women
Authors: R. Jordan, H. Brzeski, W. P. London, R. Mural, M. N. Liebman, J. Hooke, C. D. Shriver, H. Hu
Journal: Journal of Clinical Oncology (2006)

10781 Background: A number of published reports have indicated that the left breast is at greater risk of cancer than the right breast (laterality imbalance) in women of all ages. In addition, a woman’s left breast is usually larger than her right breast. In the Clinical Breast Care Project, more than 2400 subjects have been enrolled following HIPAA compliant, IRB approved protocols. Of these, 1200 have undergone a biopsy and completed demographic and pathological questionnaires. We investigated whether there is a laterality imbalance among the patients with respect to ethnicity, menopausal status or pathological diagnoses. Methods: Female patients with biopsies on only one breast whose pathological questionnaire was completed within 90 days of the demographical questionnaire were included in this analysis but patients who were surgically post-menopausal were excluded. Multiple biopsies on one breast for each woman were counted as one event. For statistical analysis, Pearson’s chi-square test in SPSS was used. Results: Of the 1200 patients, 708 (546 caucasian; CA and 172 African American; AA) satisfied the above criteria. Although the total number of biopsy events are essentially evenly distributed on either breast for either ethnicity, statistical analysis showed that post menopausal CA women have fewer biopsy events on the left breast (41%, n=264) than their pre-menopausal counterparts (52%, n = 282; p &lt; 0.05); On the contrary, post-menopausal AA women have significantly more biopsy events on the left breast (62%, n=50) than their pre-menopausal counterparts (42%, n = 122; p = 0.02). Further analysis based on pathological diagnoses indicated that benign, pre-menopausal, AA patients have fewer events on the left breast (42%, n = 98) compared to CA (54%, n = 211; p &lt; 0.05). Discussions: Despite the small sample size, the data nonetheless suggest that there are significant, menopausal status dependent, laterality imbalances of breast disease biopsy among CA and AA women. These differences await evaluation. No significant financial relationships to disclose.
Presence of clonal cells in all stem cell enriched grafts in transplanted multiple myeloma.
Authors: Ulf Thunberg, M Banghagen, B Thuresson, J Westin, A Swedin, S Lenhoff, T Olofsson, Ch Geisler, P Gimsing, N Smedegaard Andersen, B Thing Mortensen, AC Simonsen, M Bengtsson, J Sallstrom, B Simonsson, K Carlsson
Journal: Blood (1997)
Abstract 17948: In-vivo Visualization of Increased and Persistent Vascular Lipid Deposition by Nirs and Ivus Predicts Subsequent Development of High-Risk Atherosclerotic Lesions
Authors: Dhavalkumar Patel, Damir Hamamdzic, Raul Llano, Daivesh Patel, Lan Cheng, Robert Fenning, Khalid Bannan, Robert L Wilensky
Journal: Circulation (2011)

Introduction: Thin-cap fibroatheromas are the pathologic cause of acute coronary syndromes and ischemic sudden death. Near infrared spectroscopy (NIRS) detects lipid concentration in the arterial wall and intravascular ultrasound (IVUS) identifies necrotic cores and vascular remodeling. We hypothesized that concurrent use of these two invasive technologies could predict development and progression of high-risk fibroatheromas as determined by histology. Methods: Multi-vessel coronary angiography, IVUS and NIRS were performed 3, 6 and 9 months (m) after induction of diabetes (DM) and hypercholesterolemia (HC) in 21 pigs. Five animals died of ischemic sudden death and 3 of other causes. The remaining animals were sacrificed at 9-m. Results: Longitudinal IVUS data demonstrated a progressive increase in plaque + media and necrotic core areas and positive remodeling. At 9-m NIRS positivity predicted the presence of TCFAs and ThFCAs (both p=0.0001 vs NIRS negative), greater plaque (p&lt;0.0001) and necrotic core (p&lt;0.0019) areas and thinner fibrous caps (p=0.04) by histology. Importantly, NIRS positive fibroatheromas possessed a higher number of activated macrophages (p=0.006), as well as greater number of proliferating (p=0.016) and apoptotic cells (p=0.04) in the fibrous cap. NIRS positivity also predicted greater necrotic core size on IVUS scan at the subsequent time point. Moreover, 88% of arterial segments which were NIRS positive at 3 and 6-m developed into a fibroatheroma at 9-m by histology compared to 35% of persistently NIRS negative segments (p&lt;0.01). Conclusion: Results from IVUS and NIRS predicted the subsequent development of high-risk coronary fibroatheromas with greater plaque and larger necrotic core areas possessing characteristics of increased plaque instability.
Disruption of reconsolidation processes is a balancing act – can it really account for change in psychotherapy?
Authors: Rainer Spanagel, Martin Bohus
Journal: Behavioral and Brain Sciences (2015)

Abstract Lane et al. argue that any psychotherapeutic intervention at its core acts on reactivated memories via the process of reconsolidation which leads to modified memory traces. From our perspective, this model (1) only explains a small subsegment of psychotherapeutic mechanisms and (2) ignores the difficulties of generating reliable experimental conditions that allow interference with reconsolidation processes and – if successful – their transient nature.
Immuno-Catalysis and Related Fields of Bacteriology and Biochemistry
Authors: Manasseh Giragos Sevag
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incidence, Timing of Onset and Severity of Post-Thrombotic Syndrome after Acute Symptomatic Deep Vein Thrombosis: Two-Year Results from a Canadian Multicenter Prospective Cohort Study (The VETO Study).
Authors: Susan R. Kahn, Thierry Ducruet, Louise Arsenault, Marie Jose Miron, Andre Roussin, Sylvie Desmarais, France Joyal, Jeannine Kassis, Susan Solymoss, Louis Desjardins, Mira Johri, Ian Shrier, Donna L. Lamping, Jeffrey S. Ginsberg
Journal: Blood (2005)
High expression of the C-type lectin CD93 in glioblastoma vasculature enhancesvessel function by regulating cytoskeletal rearrangements and leads to poor survival
Authors: Elise Langenkamp, Lei Zhang, Roberta Lugana, Hua Huang, Tomador Elsir, Wesam Bazzar, Johan Lööf, George Trendelenburg, Fredrik Pontén, Anja Smits, Anna Dimberg
Journal: Cancer Research (2015)

Glioblastoma, grade IV glioma, is the one of the deadliest cancers, with a median survival of only 12-15 months despite aggressive treatment including surgery, chemotherapy and radiation. One hallmark of glioblastoma is the morphological and functional abnormalization of tumor blood vessels. The molecular mechanisms involved in this process and their functional and pathological implications are not yet fully understood. Indentification of molecular mechanisms that underlie vascular abnormalization in GBM is necessary to develop efficient treatment regimens for normalizing vascular function.By analyzing the RNA-content of laser microdissected vessels from human biobank specimens using affymetrix microarray analysis, we found that the abnormal glioblastoma vessels have a distinct gene expression signature. We found 95 genes which were differentially expressed in grade IV glioma vessels as compared to vessels in low grade tumors and control brain. 78 of which were up-regulated while 17 were down-regulated. Many of these genes are regulated by VEGFA or TGFβ signaling. In addition, we show a significant increase in Smad signaling complexes in the vasculature of human glioblastoma in situ, suggesting that TGFβ signaling may play important role in vessel abnormalization.CD93 is a single-pass transmembrane glycoprotein, which we found to be up-regulated in high grade glioma. Vascular expression of CD93 correlates to tumor grade in human glioma. Moreover, high grade glioma patients with high CD93 expression in the vasculature are associate with poor prognosis. We found that knocking down CD93 in endothelial cells with siRNA clearly impaired endothelial cell adhesion, migration and tube formation due to defects in cytoskeletal rearrangement. In addition, tumor growth was severely delayed in the CD93-/- mice.Pleiotrophin, a multi-functional heparin-binding growth factor, promotes glioma growth in several ways. Here, we identify pleiotrophin as a driver of vascular abnormalization in glioma. We found that high pleiotrophin expression correlates with poor survival of patients with astrocytomas. Pleiotrophin overexpression in orthotopic GL261 gliomas increases microvessel density, enhances tumour growth and decreases survival. Vessels in pleiotrophin-expressing gliomas are poorly perfused and display a high degree of abnormality, coinciding with elevated levels of vascular endothelial growth factor (VEGF) deposited in direct proximity to the vasculature. In addition to its role in vessel abnormalization, pleiotrophin enhanced PDGF-B-induced gliomagenesis. Taken together, our results indicate that PTN has an important role in glioma initiation and establishment of the characteristic abnormal tumor vasculature in glioblastoma, identifying PTN as a potential target for therapy.
Effect of early discontinuation and nonadherence to adjuvant hormone therapy on mortality in women with breast cancer.
Authors: D. L. Hershman, T. H. Shao, L. Kushi, D. Buono, W. Tsai, L. Fehrenbacher, A. I. Neugut
Journal: Journal of Clinical Oncology (2010)

578 Background: Adjuvant hormonal therapy reduces mortality among women with hormone-sensitive breast cancer (BC). We investigated the effects of early discontinuation and nonadherence to hormonal therapy on mortality in women enrolled in Kaiser Permanente of Northern California. Methods: We identified women diagnosed with hormone-sensitive stage I-III BC, 1996-2006, and used automated pharmacy records to identify hormonal therapy prescriptions and dates of refill. We categorized patients as having discontinued therapy if 180 days elapsed from the prior prescription. Of those who continued therapy, we categorized patients as adherent if the number of pills dispensed from the date of the first prescription to the date of treatment completion covered ≥ 80%. We used Cox proportional hazards models to estimate the association between discontinuation and non-adherence with all-cause mortality controlling for socio-demographic and clinical variables. Results: Among 8,769 women, median age 62 (24-99), who filled at least one prescription for hormone therapy, 2,790 (32%) discontinued therapy early. Of those who continued therapy, 1,666 (28%) were nonadherent (19% of total). Only 49% took hormonal therapy for the full duration at the optimal schedule. During a median follow-up of 4.4 years, 813 women died. Estimated survival at 10 yrs was 81% in women who continued therapy versus 74% in those who discontinued (logrank, p < 0.001). Of those who continued, survival at 10 yrs was 82% and 78% in women who adhered and nonadhered, respectively (logrank, p < 0.001). Adjusting for clinical and demographic variables, both early discontinuation (HR 1.36, 95% CI 1.17-1.57) and nonadherence (HR 1.40, 95% CI 1.16-1.71), among those who continued, were significant independent predictors of mortality. Compared to women who refilled prescriptions every 30 days, those who refilled every 90 days had improved survival (HR 0.59, 95% CI 0.51-0.71). Conclusions: Both early discontinuation and non-adherence to hormonal therapy were common and associated with increased mortality. Interventions to improve continuation of and adherence to hormonal therapy may be critical to improve BC survival. No significant financial relationships to disclose.
AN EXTRA DAY
Authors: Algernon Blackwood
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15802: Non-HDL Cholesterol in Children: Age-Related Patterns and Association With Body Fat Indices, Project Heartbeat!
Authors: Shifan Dai, Lyn M Steffen, Nicole L Mihalopoulos, Darwin R Labarthe
Journal: Circulation (2011)

Objectives: Non-HDL cholesterol (NonHC) is a combined measure of cholesterol content of all atherogenic apolipoprotein B-containing lipoproteins. The current analysis estimates trajectories related...