tbuckley/cabot-search huggingface dataset:
Myeloid-derived suppressor cells attenuate the antitumor efficacy of radiopharmaceutical therapy using<sup>90</sup>Y-NM600 in combination with androgen deprivation therapy in murine prostate tumors
Authors: Anusha Muralidhar, Reinier Hernandez, Zachary S Morris, Hansel Comas Rojas, Malick Bio Idrissou, Jamey P Weichert, Douglas G McNeel
Journal: Journal for ImmunoTherapy of Cancer (2024)

Rationale Androgen deprivation therapy (ADT) is pivotal in treating recurrent prostate cancer and is often combined with external beam radiation therapy (EBRT) for localized disease. However, for metastatic castration-resistant prostate cancer, EBRT is typically only used in the palliative setting, because of the inability to radiate all sites of disease. Systemic radiation treatments that preferentially irradiate cancer cells, known as radiopharmaceutical therapy or targeted radionuclide therapy (TRT), have demonstrable benefits for treating metastatic prostate cancer. Here, we explored the use of a novel TRT, 90 Y-NM600, specifically in combination with ADT, in murine prostate tumor models. Methods 6-week-old male FVB mice were implanted subcutaneously with Myc-CaP tumor cells and given a single intravenous injection of 90 Y-NM600, in combination with ADT (degarelix). The combination and sequence of administration were evaluated for effect on tumor growth and infiltrating immune populations were analyzed by flow cytometry. Sera were assessed to determine treatment effects on cytokine profiles. Results ADT delivered prior to TRT (ADT→TRT) resulted in significantly greater antitumor response and overall survival than if delivered after TRT (TRT→ADT). Studies conducted in immunodeficient NRG mice failed to show a difference in treatment sequence, suggesting an immunological mechanism. Myeloid-derived suppressor cells (MDSCs) significantly accumulated in tumors following TRT→ADT treatment and retained immune suppressive function. However, CD4+ and CD8+ T cells with an activated and memory phenotype were more prevalent in the ADT→TRT group. Depletion of Gr1+MDSCs led to greater antitumor response following either treatment sequence. Chemotaxis assays suggested that tumor cells secreted chemokines that recruited MDSCs, notably CXCL1 and CXCL2. The use of a selective CXCR2 antagonist, reparixin, further improved antitumor responses and overall survival when used in tumor-bearing mice treated with TRT→ADT. Conclusion The combination of ADT and TRT improved antitumor responses in murine models of prostate cancer, however, this was dependent on the order of administration. This was found to be associated with one treatment sequence leading to an increase in infiltrating MDSCs. Combining treatment with a CXCR2 antagonist improved the antitumor effect of this combination, suggesting a possible approach for treating advanced human prostate cancer.
Opportunities and Challenges in Advancing Plant Research with Single-cell Omics
Authors: Mohammad Saidur Rhaman, Muhammad Ali, Wenxiu Ye, Bosheng Li
Journal: Genomics Proteomics & Bioinformatics (2024)

Abstract Plants possess diverse cell types and intricate regulatory mechanisms to adapt to the ever-changing environment of nature. Various strategies have been employed to study cell types and their developmental progressions, including single-cell sequencing methods which provide high-dimensional catalogs to address biological concerns. In recent years, single-cell sequencing technologies in transcriptomics, epigenomics, proteomics, metabolomics, and spatial transcriptomics have been increasingly used in plant science to reveal intricate biological relationships at the single-cell level. However, the application of single-cell technologies to plants is more limited due to the challenges posed by cell structure. This review outlines the advancements in single-cell omics technologies, their implications in plant systems, future research applications, and the challenges of single-cell omics in plant systems.
Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2024
Authors: Monika Ferlitsch, Cesare Hassan, Raf Bisschops, Pradeep Bhandari, Mário Dinis-Ribeiro, Mauro Risio, Gregorios A. Paspatis, Alan Moss, Diogo Libânio, Vincente Lorenzo-Zúñiga, Andrei M. Voiosu, Matthew D. Rutter, Maria Pellisé, Leon M. G. Moons, Andreas Probst, Halim Awadie, Arnaldo Amato, Yoji Takeuchi, Alessandro Repici, Gabriel Rahmi, Hugo U. Koecklin, Eduardo Albéniz, Lisa-Maria Rockenbauer, Elisabeth Waldmann, Helmut Messmann, Konstantinos Triantafyllou, Rodrigo Jover, Ian M. Gralnek, Evelien Dekker, Michael J. Bourke
Journal: Endoscopy (2024)

1: ESGE recommends cold snare polypectomy (CSP), to include a clear margin of normal tissue (1-2 mm) surrounding the polyp, for the removal of diminutive polyps (≤ 5 mm).Strong recommendation, high quality of evidence. 2: ESGE recommends against the use of cold biopsy forceps excision because of its high rate of incomplete resection.Strong recommendation, moderate quality of evidence. 3: ESGE recommends CSP, to include a clear margin of normal tissue (1-2 mm) surrounding the polyp, for the removal of small polyps (6-9 mm).Strong recommendation, high quality of evidence. 4: ESGE recommends hot snare polypectomy for the removal of nonpedunculated adenomatous polyps of 10-19 mm in size.Strong recommendation, high quality of evidence. 5: ESGE recommends conventional (diathermy-based) endoscopic mucosal resection (EMR) for large (≥ 20 mm) nonpedunculated adenomatous polyps (LNPCPs).Strong recommendation, high quality of evidence. 6: ESGE suggests that underwater EMR can be considered an alternative to conventional hot EMR for the treatment of adenomatous LNPCPs.Weak recommendation, moderate quality of evidence. 7: Endoscopic submucosal dissection (ESD) may also be suggested as an alternative for removal of LNPCPs of ≥ 20 mm in selected cases and in high-volume centers.Weak recommendation, low quality evidence. 8: ESGE recommends that, after piecemeal EMR of LNPCPs by hot snare, the resection margins should be treated by thermal ablation using snare-tip soft coagulation to prevent adenoma recurrence.Strong recommendation, high quality of evidence. 9: ESGE recommends (piecemeal) cold snare polypectomy or cold EMR for SSLs of all sizes without suspected dysplasia.Strong recommendation, moderate quality of evidence. 10: ESGE recommends prophylactic endoscopic clip closure of the mucosal defect after EMR of LNPCPs in the right colon to reduce to reduce the risk of delayed bleeding.Strong recommendation, high quality of evidence. 11: ESGE recommends that en bloc resection techniques, such as en bloc EMR, ESD, endoscopic intermuscular dissection, endoscopic full-thickness resection, or surgery should be the techniques of choice in cases with suspected superficial invasive carcinoma, which otherwise cannot be removed en bloc by standard polypectomy or EMR.Strong recommendation, moderate quality of evidence.
Changing the paradigm of capsule endoscopy: tempting… but no (not yet)
Authors: Tom G. Moreels
Journal: Endoscopy (2024)

In this issue of Endoscopy, Rosa et al. present a study comparing efficacy and safety of pan-intestinal capsule endoscopy (PCE) using a double-headed capsule and same-day colonoscopy in patients with suspected midgut or lower gastrointestinal bleeding [1]. A total of 100 patients with iron-deficiency anemia or overt bleeding who underwent negative upper endoscopy were included. They were given extensive split-dose bowel cleansing with additional boosters prior to capsule ingestion in the morning; 10 hours later they underwent conventional colonoscopy. Findings of both examinations were compared. The results are in favor of PCE as a first-line procedure in cases of suspected mid or lower gastrointestinal bleeding, thanks to positive PCE findings in 46% of the patients, with excellent efficacy (96% sensitivity, 100% specificity, 96% negative predictive value, and 100% positive predictive value) and safety. Should this approach (PCE-first instead of colonoscopy) be adopted after negative upper endoscopy? Are we ready to dismiss conventional colonoscopy after negative PCE? Or should diagnostic PCE become the very first examination before submitting patients to more invasive conventional endoscopic procedures with exclusive therapeutic intent?
Electrical Impedance Tomography-based Ventilation Patterns for Evaluating Proper Ventilator Settings and to Classify Lung Morphofunction
Authors: Caio C. A. Morais, Lorenzo Berra, Elias Baedorf Kassis, Rodrigo A. Cornejo, Shirley L. Campos, Daniella C. Brandão, Armèle Dornelas de Andrade, Marcelo B. P. Amato, Eduardo L. V. Costa
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Electrical Impedance Tomography-based Ventilation Patterns for Evaluating Proper Ventilator Settings and to Classifying Lung Morphofunction." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Outcomes of HLA-mismatched HSCT with TCRαβ/CD19 depletion or post-HSCT cyclophosphamide for inborn errors of immunity
Authors: Su Han Lum, Michael H Albert, Patrick Gilbert, Tiarlan Sirait, Mattia Algeri, Rafaella Muratori, Benjamin Fournier, Alexandra Laberko, Musa Karakukcu, Ekrem Unal, Mouhab F Ayas, Satya Prakash Yadav, Tunc Fisgin, Reem Elfeky, Juliana Folloni Fernandes, Maura Faraci, Theresa Cole, Ansgar S Schulz, Roland Meisel, Marco Zecca, Marianne Ifversen, Alessandra Biffi, Jean-Sebastien Diana, Tanja C. Vallée, Stefano Giardino, Gizem Zengin Ersoy, Despina Moshous, Andrew R Gennery, Dmitry Balashov, Carmem M.S. Bonfim, Franco Locatelli, Arjan C Lankester, Bénédicte Neven, Mary A Slatter
Journal: Blood (2024)
Language in Brains, Minds, and Machines
Authors: Greta Tuckute, Nancy Kanwisher, Evelina Fedorenko
Journal: Annual Review of Neuroscience (2024)

It has long been argued that only humans could produce and understand language. But now, for the first time, artificial language models (LMs) achieve this feat. Here we survey the new purchase LMs are providing on the question of how language is implemented in the brain. We discuss why, a priori, LMs might be expected to share similarities with the human language system. We then summarize evidence that LMs represent linguistic information similarly enough to humans to enable relatively accurate brain encoding and decoding during language processing. Finally, we examine which LM properties—their architecture, task performance, or training—are critical for capturing human neural responses to language and review studies using LMs as in silico model organisms for testing hypotheses about language. These ongoing investigations bring us closer to understanding the representations and processes that underlie our ability to comprehend sentences and express thoughts in language.
Impact of liquid sublingual immunotherapy on asthma onset and progression in patients with allergic rhinitis: a nationwide population-based study (EfficAPSI study)
Authors: Pascal Demoly, Mathieu Molimard, Jean-François Bergmann, Bertrand Delaisi, Amandine Gouverneur, Jade Vadel, Cédric Collin, Laurence Girard, Silvia Scurati, Philippe Devillier
Journal: The Lancet Regional Health - Europe (2024)

The only disease-modifying treatment currently available for allergic rhinitis (AR) is allergen immunotherapy (AIT). The main objective of the EfficAPSI real-world study (RWS) was to evaluate the impact of liquid sublingual immunotherapy (SLIT-liquid) on asthma onset and evolution in AR patients.
Association between particulate air pollution and hypertensive disorders in pregnancy: A retrospective cohort study
Authors: Yi Sun, Rashmi Bhuyan, Anqi Jiao, Chantal C. Avila, Vicki Y. Chiu, Jeff M. Slezak, David A. Sacks, John Molitor, Tarik Benmarhnia, Jiu-Chiuan Chen, Darios Getahun, Jun Wu
Journal: PLoS Medicine (2024)

Epidemiological findings regarding the association of particulate matter ≤2.5 μm (PM2.5) exposure with hypertensive disorders in pregnancy (HDP) are inconsistent; evidence for HDP risk related to PM2.5 components, mixture effects, and windows of susceptibility is limited. We aimed to investigate the relationships between HDP and exposure to PM2.5 during pregnancy.
Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity
Authors: Tianxiang Zhang, Weiwei Yu, Xiaoxiao Cheng, Jacky Yeung, Viviana Ahumada, Paul C. Norris, Mackenzie J. Pearson, Xuan Yang, Willemijn van Deursen, Christina Halcovich, Ala Nassar, Matthew D. Vesely, Yu Zhang, Jian-Ping Zhang, Lan Ji, Dallas B. Flies, Linda Liu, Solomon Langermann, William J. LaRochelle, Rachel Humphrey, Dejian Zhao, Qiuyu Zhang, Jindong Zhang, Runxia Gu, Kurt A. Schalper, Miguel F. Sanmamed, Lieping Chen
Journal: Science Immunology (2024)

T cells are often absent from human cancer tissues during both spontaneously induced immunity and therapeutic immunotherapy, even in the presence of a functional T cell-recruiting chemokine system, suggesting the existence of T cell exclusion mechanisms that impair infiltration. Using a genome-wide in vitro screening platform, we identified a role for phospholipase A2 group 10 (PLA2G10) protein in T cell exclusion. PLA2G10 up-regulation is widespread in human cancers and is associated with poor T cell infiltration in tumor tissues. PLA2G10 overexpression in immunogenic mouse tumors excluded T cells from infiltration, resulting in resistance to anti-PD-1 immunotherapy. PLA2G10 can hydrolyze phospholipids into small lipid metabolites, thus inhibiting chemokine-mediated T cell mobility. Ablation of PLA2G10's enzymatic activity enhanced T cell infiltration and sensitized PLA2G10-overexpressing tumors to immunotherapies. Our study implicates a role for PLA2G10 in T cell exclusion from tumors and suggests a potential target for cancer immunotherapy.
Novel transcriptomic panel identifies histologically active eosinophilic oesophagitis
Authors: Emilie Gueguen, Yasser Morsy, Céline Mamie, Alain Schoepfer, Catherine Saner, Luc Biedermann, Alex Straumann, Andrea Kreienbühl, Michael Scharl, Marcin Wawrzyniak
Journal: Gut (2024)

Background and aims Eosinophilic oesophagitis (EoE) is characterised by symptoms of esophageal dysfunction and oesinophil tissue infiltration. The EoE Diagnostic Panel (EDP) can distinguish between active and non-active EoE using a set of 77 genes. Recently, the existence of distinct EoE variants featuring symptoms similar to EoE, such as oesophageal dysfunction but lacking eosinophil infiltration, had been determined. Methods We used oesophageal biopsies from patients with histologically active (n=10) and non-active EoE (n=9) as well as from healthy oesophageal controls (n=5) participating in the Swiss Eosinophilic Esophagitis Cohort Study (SEECS) and analysed the gene expression profile in these biopsies by total RNA-sequencing (RNA-seq). Moreover, we employed the publicly accessible RNA-seq dataset (series GSE148381) as reported by Greuter et al , encompassing a comprehensive genomic profile of patients presenting with EoE variants. Results A novel, diagnostic gene expression panel that can effectively distinguish patients with histologically active conventional EoE from patients with EoE in histological remission and control individuals, and from three newly discovered EoE variants was identified. Histologically Active EoE Diagnostic Panel (HAEDP) consists of 53 genes that were identified based on differential expression between histologically active EoE, histological remission and controls (p≤0.05). By combining the HAEDP with EDP, we expanded our knowledge about factors that may contribute to the inflammation in EoE and improved our understanding of the underlying mechanisms of the disease. Conversely, we suggested a compact group of genes common to both HAEDP and EDP to create a reliable diagnostic tool that might enhance the accuracy of EoE diagnosis. Conclusion We identified a novel set of 53 dysregulated genes that are closely associated with the histological inflammatory activity of EoE. In combination with EDP, our new panel might be a valuable tool for the accurate diagnosis of patients with EoE as well as for monitoring their disease course.
Inappropriate use of proton pump inhibitors in clinical practice globally: a systematic review and meta-analysis
Authors: Amit K Dutta, Vishal Sharma, Abhinav Jain, Anshuman Elhence, Manas K Panigrahi, Srikant Mohta, Richard Kirubakaran, Mathew Philip, Mahesh Goenka, Shobna Bhatia, Usha Dutta, D Nageshwar Reddy, Rakesh Kochhar, Govind K Makharia
Journal: Gut (2024)
Population incidence and associated mortality of urinary tract infection in people living with dementia
Authors: Helen Lai, Magdalena Kolanko, Lucia M Li, Megan E Parkinson, Niall J Bourke, Neil S N Graham, Michael C B David, Emma-Jane Mallas, Bowen Su, Sarah Daniels, Danielle Wilson, Mara Golemme, Claire Norman, Kirsten Jensen, Raphaella Jackson, Martin Tran, Paul S Freemont, David Wingfield, Tim Wilkinson, Edward W Gregg, Ioanna Tzoulaki, David J Sharp, Eyal Soreq
Journal: Journal of Infection (2024)
Experience of dupilumab treatment in inherited epidermolysis bullosa: A short series
Authors: Nathalia Bellon, Pauline Bataille, Julie Bonigen, Fabienne Charbit-Henrion, Céline Dietrich, Laura Polivka, Smail Hadj-Rabia, Maria Leite de Moraes, Christine Bodemer
Journal: Journal of the American Academy of Dermatology (2024)
Geographic Accessibility and Completion of Initial Low-Dose CT-Based Lung Cancer Screening in an Urban Safety-Net Population
Authors: Sofia Yi, Rutu A. Rathod, Vijaya Subbu Natchimuthu, Sheena Bhalla, Jessica L. Lee, Travis Browning, Joyce O. Adesina, Minh Do, David Balis, Juana Gamarra de Wiliams, Ellen Kitchell, Noel O. Santini, David H. Johnson, Heidi A. Hamann, Simon J. Craddock Lee, Amy E. Hughes, David E. Gerber
Journal: Journal of the National Comprehensive Cancer Network (2024)

Background: Recent modifications to low-dose CT (LDCT)–based lung cancer screening guidelines increase the number of eligible individuals, particularly among racial and ethnic minorities. Because these populations disproportionately live in metropolitan areas, we analyzed the association between travel time and initial LDCT completion within an integrated, urban safety-net health care system. Methods: Using Esri’s StreetMap Premium, OpenStreetMap, and the r5r package in R, we determined projected private vehicle and public transportation travel times between patient residence and the screening facility for LDCT ordered in March 2017 through December 2022 at Parkland Memorial Hospital in Dallas, Texas. We characterized associations between travel time and LDCT completion in univariable and multivariable analyses. We tested these associations in a simulation of 10,000 permutations of private vehicle and public transportation distribution. Results: A total of 2,287 patients were included in the analysis, of whom 1,553 (68%) completed the initial ordered LDCT. Mean age was 63 years, and 73% were underrepresented minorities. Median travel time from patient residence to the LDCT screening facility was 17 minutes by private vehicle and 67 minutes by public transportation. There was a small difference in travel time to the LDCT screening facility by public transportation for patients who completed LDCT versus those who did not (67 vs 66 min, respectively; P =.04) but no difference in travel time by private vehicle for these patients (17 min for both; P =.67). In multivariable analysis, LDCT completion was not associated with projected travel time to the LDCT facility by private vehicle (odds ratio, 1.01; 95% CI, 0.82–1.25) or public transportation (odds ratio, 1.14; 95% CI, 0.89–1.44). Similar results were noted across travel-type permutations. Black individuals were 29% less likely to complete LDCT screening compared with White individuals. Conclusions: In an urban population comprising predominantly underrepresented minorities, projected travel time is not associated with initial LDCT completion in an integrated health care system. Other reasons for differences in LDCT completion warrant investigation.
Abnormal Glucose, Triglycerides Linked to Later Psychiatric Conditions
Authors: Emily Harris
Journal: JAMA (2024)

Charilaos Chourpiliadis, MD; Yu Zeng, MSc; Anikó Lovik, PhD; Dang Wei, MD, PhD; Unnur Valdimarsdóttir, PhD; Huan Song, MD, PhD; Niklas Hammar, PhD; Fang Fang, MD, PhD
Effect of sleep on oral health: A scoping review
Authors: Jainy Shah, Brianna F. Poirier, Joanne Hedges, Lisa Jamieson, Sneha Sethi
Journal: Sleep Medicine Reviews (2024)

Sleep is a vital biological process that facilitates numerous vital functions integral to mental and physical restoration of the body. Sleep deprivation or poor sleep quality not only affects physical health but may also affect oral health. This scoping review aims to collate existing evidence related to the impact of sleep duration and/or quality on oral health. A systematic search strategy using PubMed, Embase, Scopus and CINAHL databases was performed to identify studies that assessed the association between sleep quality or duration and oral health or hygiene. Two researchers independently screened and extracted the data. Eligible studies were critically appraised using the NIH quality assessment tool for observational cohort and cross-sectional studies checklist. The search identified 18,398 studies, from which 14 fulfilled the inclusion criteria. Of the 14 papers, four papers were associated with effect of sleep on caries, 8 papers described the effect of sleep on gingival and periodontal health, and two papers described the effect of sleep on general oral health and oral disease symptoms. This review found a direct link between sleep and dental decay in children, and short sleep duration was associated with an increased risk of periodontitis adults.
Digital Health Interventions and Patient Safety in Abdominal Surgery
Authors: Artem Grygorian, Diego Montano, Mahdieh Shojaa, Maximilian Ferencak, Norbert Schmitz
Journal: JAMA Network Open (2024)

Over the past 2 decades, several digital technology applications have been used to improve clinical outcomes after abdominal surgery. The extent to which these telemedicine interventions are associated with improved patient safety outcomes has not been assessed in systematic and meta-analytic reviews.
COVID-19 Vaccine Uptake in Undocumented Latinx Patients Presenting to the Emergency Department
Authors: Jesus R. Torres, Breena R. Taira, Angela Bi, Andrew V. Gomez, Cynthia Delgado, Stephanie Vera, Robert M. Rodriguez
Journal: JAMA Network Open (2024)

This cross-sectional study examines COVID-19 infection status, vaccination uptake, and perceptions about the vaccine among Latinx patients presenting to the emergency department in California.
Access to Mental Health and Substance Use Treatment in Comprehensive Primary Care Plus
Authors: Tatiane Santos, Alon Bergman, Aaron Smith-McLallen
Journal: JAMA Network Open (2024)

To meet increasing demand for mental health and substance use services, the Centers for Medicare & Medicaid Services launched the 5-year Comprehensive Primary Care Plus (CPC+) demonstration in 2017, requiring primary care practices to integrate behavioral health services.