tbuckley/cabot-search huggingface dataset:
Winter seasonal affective disorder: a follow-up study of the first 59 patients of the National Institute of Mental Health Seasonal Studies Program
Authors: P J Schwartz, C Brown, T A Wehr, N E Rosenthal
Journal: American Journal of Psychiatry (1996)

The purpose of this study was to characterize the long-term course of patients with seasonal affective disorder.The first 59 patients with winter seasonal affective disorder who had entered winter protocols were retrospectively followed up after a mean interval of 8.8 years. Detailed life charts were constructed through use of a semistructured interview and collateral records.The disorder of 25 patients (42%) remained purely seasonal, with regular recurrences of winter depression and no depression or treatment through any summer. The course of illness was complicated by varying degrees of nonseasonal depression in 26 patients (44%). The disorders of eight patients (14%) had fully remitted. Certain features of the group with complicated seasonal affective disorder suggested that they were more severely ill. Twenty-four patients (41%) continued to use light treatment regularly throughout the follow-up period. Light treatment was preferred to medication for winter recurrences, although antidepressants had been used in the winter by most (63%) of the patients who still used lights at follow-up.The pattern of winter depressions and summer remissions remained fairly persistent over time in this group of patients. The temporal distribution of depressive episodes both within and across individual patients was consistent with the results of several recent follow-up studies of seasonal affective disorder, providing support for the predictive and construct validity of the Rosenthal et al. diagnosis of winter seasonal affective disorder. Light treatment, while remaining a safe and satisfactory treatment for many, may be insufficient for more severely ill patients. The appearance of nonseasonal depressions in patients with winter seasonal affective disorder may be associated with greater severity of illness and less responsiveness to light treatment.
Interim report on pandemic H1N1 influenza virus infections in South Africa, April to October 2009: Epidemiology and factors associated with fatal cases
Authors: B N Archer, C Cohen, D Naidoo, J Thomas, C Makunga, L Blumberg, M Venter, G A Timothy, A Puren, J M McAnerney, A Cengimbo, B D Schoub
Journal: Eurosurveillance (2009)

We provide an interim report on pandemic H1N1 influenza activity in South Africa, with a focus on the epidemiology and factors associated with deaths. Following the importation of the virus on 14 July 2009, and the epidemic peak during the week starting 3 August, the incidence in South Africa has declined. A total of 12,331 cases and 91 deaths have been laboratory-confirmed as of 12 October 2009. Age distribution and risk groups were similar to those observed elsewhere. The median age of patients who died (33.5 years) was significantly higher than that of the non-fatal cases (15.0 years, p&lt;0.01). The most common underlying conditions among fatal cases were infection with human immunodeficiency virus (17/32 tested) and pregnancy (25/45 women of reproductive age). Active tuberculosis coinfection was present in seven of 72 fatal cases. These findings should be taken into consideration when planning vaccination strategies for 2010.
WMA looks at doctors' role when resources are limited GPs were inadequately consulted over community care MPs reject bill to ban boxing Rescued private hospital takes NHS patients Community health councils will have code of conduct NHS introduces quarterly review Complaints implementation group needs more doctors
Authors: L. Beecham
Journal: BMJ (1995)

# WMA looks at doctors' role when resources are limited {#article-title-2}

At its recent meeting in France the council of the World Medical Association decided that doctors had to balance the ethical principle of fairness for all patients against their duty to seek the best treatment for their own patients. Members were considering a draft paper on aspects of the allocation of health care resources and the doctors' role. Some believed that they had no such role, some distinguished between their own resources and those of society, and some considered that they had a responsibility to other patients besides their own. A further paper will be prepared for national medical associations to consider.

The council expressed concern about the increasing use of weapons, including antipersonnel mines which target civilian populations indiscriminately. It supported the campaign by the International Committee of the Red Cross to publicise the devastating effects of landmines and to convince governments to take preventive and remedial measures to reduce the number of victims.

The WMA has agreed to collaborate with other organisations, such as the World Health Organisation, on the increase in antibiotic resistant organisms. The representatives of the American Medical Association said that they were concerned that the misuse and overuse of antibiotics would result in useless drugs and in pathogenic micro-organisms that were resistant to many if not all currently available antibiotics.

The WMA, which is an independent confederation of 64 national medical associations, will meet next in Bali, Indonesia, in September.

# GPs were inadequately consulted over community care {#article-title-3}

General practitioners in the North Thames region say that they were not consulted adequately before the community care reforms were introduced; that the aims of enhanced choice …
Abstract 917: Fabry’s Disease Mimicking Hypertrophic Cardiomyopathy (HCM)- Screening For Galactosidase (GAL) Gene Mutations in a HCM Cohort
Authors: Ole Havndrup, Paal S Andersen, Morten Jensen, Michael Christiansen, Lars Kober, Henning Bundgaard
Journal: Circulation (2006)

Introduction: Hypertrophic cardiomyopathy (HCM) is caused by mutations in genes encoding cardiac sarcomere proteins. However, ECG and echocardiographic changes seen in Fabry’s disease - that is cau...
The Predictive Value of Microscopic Haematuria in Patients with Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia
Authors: K. Ezz El Din, W.F.R.M. Koch, M.J.A.M. de Wildt, F.M.J. Dehruyne, J.J.M.C.H. de la Rosette
Journal: European Urology (1996)
MULTIDISCIPLINARY ACCIDENT INVESTIGATION. A LITERATURE SURVEY AND AN ACCOUNT OF MULTIDISCIPLINARY INVESTIGATIONS OF ROAD TRAFFIC ACCIDENTS IN THE NORDIC COUNTRIES
Authors: A Englund
Journal: BMJ (1978)

In the Nordic Road Safety Council's Project methods for the collection and presentation of accident data (miro) a literature survey has been performed concerning multidisciplinary investigations of road accidents. This study has been one of three sub-projects in the first phase of the miro-project. After an introductory, short historical outline various aspects are presented concerning the design and performance of projects with multidisciplinary accident investigations. This regards background, objectives and different factors which have influenced project design - eg methodological questions - and the extent to which this is described and discussed in reports in this area. Further aspects dealt with in the study are the composition of the investigation group, methodology for alarm, mobilization and work on the accident scene, collection of data, data processing and analysis, presentation and utilization of results. Costs and administrative problems in connection with multidisciplinary accident investigations concludes this part. The survey also contains an account of two intervational projects and a section outlining the salient features of a total of six multidisciplinary accident investigation projects which have been conducted or are now in progress in the nordic countries. /TRRL/
THE BEHAVIORAL RESPONSE OF PATIENTS SEIZED WITH AN ACUTE MYOCARDIAL INFARCTION
Authors: S W McLEOD
Journal: Annals of Internal Medicine (1949)

Article1 April 1949THE BEHAVIORAL RESPONSE OF PATIENTS SEIZED WITH AN ACUTE MYOCARDIAL INFARCTIONSTUART W. MCLEOD, M.D.STUART W. MCLEOD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-4-757 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical features associated with an acute episode of a coronary occlusion with myocardial infarction are so well known to the medical profession today that the diagnosis of this condition is usually made with ease on the basis of the history and physical examination. This has been due to the pioneering work of Herrick,1, 2, 3 Dock,4 Wearn,5 and Levine6 as well as others who were among the first to point out the essential symptomatology and physical findings upon which the diagnosis rests.The purpose of this paper is to present an additional feature of the disease which may be...Bibliography1. HERRICK JB: Clinical features of sudden obstruction of the coronary arteries, Jr. Am. Med. Assoc., 1912, lix, 2015-2020. CrossrefGoogle Scholar2. HERRICKNUZUM JBFR: Angina pectoris: Clinical experience with 200 cases, Jr. Am. Med. Assoc., 1918, lxx, 67-70. CrossrefGoogle Scholar3. HERRICK JB: Thrombosis of the coronary arteries, Jr. Am. Med. Assoc., 1919, lxxii, 387-390. CrossrefGoogle Scholar4. DOCK G: Some notes on the coronary arteries, Med. and Surg. Rep., 1896, lxxv, 1-7. Google Scholar5. WEARN JT: Thrombosis of the coronary arteries with infarction of the heart, Am. Jr. Med. Sci., 1923, clxv, 150-176. Google Scholar6. LEVINEBROWN SACL: Coronary thrombosis: Its various clinical features, Medicine, 1929, iii, 245-418. CrossrefGoogle Scholar7. WHITE PD: Heart Disease, Third edition, 1943, Macmillan & Company, New York, page 490. Google Scholar8. EGGLESTON C: Cecil's Textbook of Medicine, Sixth edition, 1943, W. B. Saunders & Company, Philadelphia, page 1096. Google Scholar9. LEVINE SA: Clinical Heart Disease, Third edition, 1945, W. B. Saunders & Company, Philadelphia, pages 108-109. Google Scholar10. CHAMBERS WN: Acute myocardial infarction, New Eng. Jr. Med., 1946, ccxxxv, 347-352. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York*Received for publication January 17, 1948. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1949Volume 30, Issue 4Page: 757-765KeywordsAcute myocardial infarctionMyocardial infarction ePublished: 1 December 2008 Issue Published: 1 April 1949 PDF downloadLoading ...
Public confidence and cardiac surgical outcome
Authors: B. E Keogh, J. Dussek, D. Watson, P. Magee, D. Wheatley
Journal: BMJ (1998)

<h3>Abstract</h3> A wide range of proteins have been reported to condensate into a dense liquid phase, forming a reversible droplet state. Failure in the control of the droplet state can lead to the formation of the more stable amyloid state, which is often disease-related. These observations prompt the question of how many proteins can undergo liquid-liquid phase separation. Here, in order to address this problem, we discuss the biophysical principles underlying the droplet state of proteins by analyzing current evidence for droplet-driver and droplet-client proteins. Based on the concept that the droplet state is stabilized by the large conformational entropy associated with non-specific side-chain interactions, we develop the FuzDrop method to predict droplet-promoting regions and proteins, which can spontaneously phase separate. We use this approach to carry out a proteome-level study to rank proteins according to their propensity to form the droplet state, spontaneously or via partner interactions. Our results lead to the conclusion that the droplet state could be, at least transiently, accessible to most proteins under conditions found in the cellular environment. <h3>Significance</h3> Liquid-liquid phase separation of proteins results in biomolecular condensates, which contribute to the organisation of cellular matter into membraneless organelles. It is still unclear, however, whether these condensates represent a common state of proteins. Here, based on biophysical principles driving phase separation, we report a proteome-wide ranking of proteins according to their propensity to condensate into a droplet state. We analyze two mechanisms for droplet formation - driver proteins can spontaneously phase separate, while client proteins require additional components. We conclude that the droplet state, as the native and amyloid states, is a fundamental state of proteins, with most proteins expected to be capable of undergoing liquid-liquid phase separation via either of these two mechanisms.
Factors in the development of severe forms of tardive dyskinesia
Authors: R Yassa, N P Nair, H Iskander, G Schwartz
Journal: American Journal of Psychiatry (1990)

The authors evaluated 558 patients for tardive dyskinesia. They found that the prevalence of tardive dyskinesia was 34%. There were no differences between men and women in prevalence of tardive dyskinesia. However, severe tardive dyskinesia was found to occur more in male patients 40 years old or younger and in female patients 71 years old or older. Patients with mild tardive dyskinesia received more neuroleptics than did patients with moderate and severe forms. However, patients with moderate tardive dyskinesia had significantly more drug-free periods in their drug histories than did patients with mild tardive dyskinesia.
Abstract 20062: The Anti-Apoptotic Protein Mcl-1 is an Important Regulator of Mitochondrial Turnover
Authors: Youngil Lee, Chengqun Huang, Robert L Thomas, Melissa N Quinsay, Shivaji Rikka, Dieter A Kubli, Kimberlee M Fischer, Mark A Sussman, Asa B Gustafsson
Journal: Circulation (2010)

Mcl-1 is an anti-apoptotic Bcl-2 protein which is expressed at high levels in the heart compared to other anti-apoptotic Bcl-2 proteins. Surprisingly, very little is known with respect to how Mcl-1...
Molecular understanding of sensitivity to chemotherapeutic agents in medulloblastoma
Authors: D Meley, D Spiller, M White, H McDowell, B Pizer, V See
Journal: Neuro-Oncology (2008)

Meley, Daniel Spiller, David White, Michael Mcdowell, Heather Pizer, Barry See, Violaine 13th International Symposium on Pediatric Neuro-Oncology Jun 29-jul 02, 2008 Chicago, IL
LIGATION OF A PATENT DUCTUS ARTERIOSUS WITH PROBABLE ENDARTERITIS; APPARENT CURE
Authors: J. W. Nixon, W. W. Bondurant, Omer Roan
Journal: Annals of Internal Medicine (1943)

Case Reports1 December 1943LIGATION OF A PATENT DUCTUS ARTERIOSUS WITH PROBABLE ENDARTERITIS; APPARENT CUREJ. W. NIXON, M.D., F.A.C.S., W. W. BONDURANT JR., M.D., F.A.C.P., OMER ROAN, M.D., F.A.C.S.J. W. NIXON, M.D., F.A.C.S.Search for more papers by this author, W. W. BONDURANT JR., M.D., F.A.C.P.Search for more papers by this author, OMER ROAN, M.D., F.A.C.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-6-1003 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUnusual consideration is now being given in America to the surgical treatment of patent ductus arteriosus. One of us (Nixon) has recently reviewed the surgical aspects of the disease. Since the report of Touroff et al. of the cure of three cases of subacuteStreptococcus viridansendarteritis following the successful surgical ligation of a patent ductus arteriosus, renewed interest has been shown in subacute endarteritis of this type. Their work definitely extends the benefit of surgical ligation of patent ductus arteriosus by offering a possible cure of this very serious complication. The report of an additional case successfully treated by... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Antonio, Texas*Received for publication August 11, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySurgical Closure of the Patent Ductus Arteriosus 1 December 1943Volume 19, Issue 6Page: 1003-1007KeywordsGamesHeart murmursLigation assayPatent ductus arteriosusSportsStreptococcusTemperature ePublished: 1 December 2008 Issue Published: 1 December 1943 PDF downloadLoading ...
Abstract 2572: Relationship Between Circumferential and Radial Strain Rate in the Endocardium and the Epicardium: Validation Study Using an In-Vitro Pumped Pig Heart Model
Authors: Giant C Lin, Yin Han Kwee, Jessica E Coffman, Margaret S Soper, Kenneth R Gundle, Brent J Barber, Xiao Kui Li, David J Sahn
Journal: Circulation (2007)
Abstract 8252: Altered Metabolism of Post-Prandial Remnant Lipoprotein Fractions in Autosomal Recessive Hypercholesterolemia
Authors: Hayato Tada, Masa-aki Kawashiri, Takamitsu Nakano, Katsuyuki Nakajima, Toshinari Tsubokawa, Tetsuo Konno, Kenshi Hayashi, Katsuharu Uchiyama, Atsushi Nohara, Noboru Fujino, Hidekazu Ino, Akihiro Inazu, Junji Kobayashi, Hiroshi Mabuchi, Masakazu Yamagishi
Journal: Circulation (2011)

Introduction: Autosomal recessive hypercholesterolemia (ARH) associated with mutations in LDLR adaptor protein 1 (LDLRAP1) gene is extremely rare disorder. Although this defect seems to be a phenocopy of homozygous familial hypercholesterolemia (FH), clinical phenotype of ARH seems less severe, more responsive to statins, the cause of which may be derived from the difference of remnant-like particles (RLP) clearance. Hypothesis: We assessed the hypothesis that the ability of RLP clearance of ARH subject was different from that of FH subject. Methods: OFTT cream (Jomo Shokuhin, Takasaki, Japan) 50 g was given per body surface area (squared meter), blood sampling was performed at 2 hour intervals up to 6 hour. Plasma lipoprotein and RLP fraction were determined by HPLC system in one ARH subject (68yr, LDL-C=286mg/dl), 4 heterozygous FH subjects (58±17yr, LDL-C=241±26mg/dl), and 4 controls (62±17yr, LDL-C=88±6mg/dl). All male subjects were selected to have apolipoprotein E2/E3 phenotype without diabetes. None of the subjects took medication known to affect plasma lipids at the time of this study for at least 4 weeks. The area under curve (AUC) of TG, RLP-TG, and RLP-cholesterol levels were evaluated. Results: After oral fat load, the AUC of TG, RLP-TG, and RLP-cholesterol levels of heterozygous FH subjects were significantly increased compared to those of controls (441±87 mg/dl*hour vs 316±133 mg/dl*hour, p&lt;0.05, 126±60 mg/dl*hour vs 49±11 mg/dl*hour, p&lt;0.05, 34±8 mg/dl*hour vs 23±11 mg/dl*hour, p&lt;0.05, respectively). In contrast to these results, the AUC of TG, RLP-TG, and RLP-cholesterol levels of ARH were within the nomal range (310mg/dl*hour, 23mg/dl*hour, 22mg/dl*hour, respectively). Conclusions: These results suggest that the lack of LDLRAP1 modulates RLP metabolism, activating an alternate pathway which can remove remnant fraction paradoxically. This preferred pathway should contribute to the greater responsiveness to statins. Our results will provide new insights into the lipoprotein metabolism of ARH and the novel pharmacological target for LDLRAP1.
Benzimidazole derivatives: search for GI-friendly anti-inflammatory analgesic agents
Authors: Monika Gaba, Punam Gaba, Deepika Uppal, Neelima Dhingra, Malkeet Singh Bahia, Om Silakari, Chander Mohan
Journal: Acta Pharmaceutica Sinica B (2015)

Non-steroidal anti-inflammatory drugs (NSAIDs) have been successfully used for the alleviation of pain and inflammation in the past and continue to be used daily by millions of patients worldwide. However, gastrointestinal (GI) toxicity associated with NSAIDs is an important medical and socioeconomic problem. Local generation of various reactive oxygen species plays a significant role in the formation of gastric ulceration associated with NSAIDs therapy. Co-medication of antioxidants along with NSAIDs has been found to be beneficial in the prevention of GI injury. This paper describes the synthesis and biological evaluation of N-1-(phenylsulfonyl)-2-methylamino-substituted-1H-benzimidazole derivatives as anti-inflammatory analgesic agents with lower GI toxicity. Studies in vitro and in vivo demonstrated that the antioxidant activity of the test compounds decreased GI toxicity.
Dosage of Dabigatran as a Risk Factor for Bleeding in Atrial Fibrillation
Authors: Siyao Liu, Cherub O. Kim, Scott N. Lucyk
Journal: JAMA Internal Medicine (2015)

To the Editor We read with interest the recent article by Hernandez et al1 regarding bleeding risk in patients with atrial fibrillation treated with dabigatran. This work contributes to the ongoing debate regarding optimal anticoagulant use in patients with atrial fibrillation.
THE GENESIS OF THE NEUROSES
Authors: S B HADDEN
Journal: Annals of Internal Medicine (1947)

Article1 August 1947THE GENESIS OF THE NEUROSESSAMUEL B. HADDEN, M.D., F.A.C.P.SAMUEL B. HADDEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-2-282 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Second World War focused much attention upon the psychoneuroses, and to many the fact that over a million of our young men were not fit for military service because of psychoneuroses was a jolt. Much has been written about the rôle of the war in the production of the psychoneuroses—but military service did little more than act as the precipitating factor, since almost as many young men were rejected for service as were dismissed from the armed forces because of neurotic disorders. Psychoneurotic illness has always been with us, and I do not believe it will ever be eliminated... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Read at the Regional Meeting of the American College of Physicians, February 7, 1947.From the Department of Psychiatry, University of Pennsylvania School of Medicine, and from the Department of Neuropsychiatry of the Presbyterian Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1947Volume 27, Issue 2Page: 282-288KeywordsArmed forcesHospital medicine ePublished: 1 December 2008 Issue Published: 1 August 1947 PDF downloadLoading ...