tbuckley/cabot-search huggingface dataset:
The Genetic Pathophysiology and Clinical Management of the TADopathy, X-Linked Acrogigantism
Authors: Adrian F Daly, Albert Beckers
Journal: Endocrine Reviews (2024)

Abstract Pituitary gigantism is a rare manifestation of chronic growth hormone (GH) excess that begins before closure of the growth plates. Nearly half of patients with pituitary gigantism have an identifiable genetic cause. X-linked acrogigantism (X-LAG; 10% of pituitary gigantism) typically begins during infancy and can lead to the tallest individuals described. In the 10 years since its discovery, about 40 patients have been identified. Patients with X-LAG usually develop mixed GH and prolactin macroadenomas with occasional hyperplasia that secrete copious amounts of GH, and frequently prolactin. Circulating GH-releasing hormone is also elevated in a proportion of patients. X-LAG is caused by constitutive or sporadic mosaic duplications at chromosome Xq26.3 that disrupt the normal chromatin architecture of a topologically associating domain (TAD) around the orphan G-protein–coupled receptor, GPR101. This leads to the formation of a neo-TAD in which GPR101 overexpression is driven by ectopic enhancers (“TADopathy”). X-LAG has been seen in 3 families due to transmission of the duplication from affected mothers to sons. GPR101 is a constitutively active receptor with an unknown natural ligand that signals via multiple G proteins and protein kinases A and C to promote GH/prolactin hypersecretion. Treatment of X-LAG is challenging due to the young patient population and resistance to somatostatin analogs; the GH receptor antagonist pegvisomant is often an effective option. GH, insulin-like growth factor 1, and prolactin hypersecretion and physical overgrowth can be controlled before definitive adult gigantism occurs, often at the cost of permanent hypopituitarism.
Paravalvular regurgitation after transcatheter aortic valve replacement: incidence, quantification, and prognostic impact
Authors: Marleen van Wely, Maxim Rooijakkers, Niels Stens, Saloua El Messaoudi, Tim Somers, Leen van Garsse, Dick Thijssen, Robin Nijveldt, Niels van Royen
Journal:  (2024)

Abstract Transcatheter aortic valve replacement (TAVR) is the standard of care in aortic stenosis with results comparable to surgical aortic valve replacement. However, paravalvular regurgitation (PVR) is more common after TAVR. With the alteration of devices and implantation techniques, the incidence of moderate or more PVR has declined. Mild PVR is still common in around 30% of TAVR patients in low-risk trials. Progression of AS causes myocardial hypertrophy and varying degrees of diastolic dysfunction which may cause heart failure even in combination with small volumes of PVR. Any degree of PVR is associated with an increased risk of overall and cardiovascular mortality. Predictors of PVR are annular eccentricity, severe calcification of the aortic valve, bicuspid aortic valves, and type of prosthesis where balloon-expandable devices are associated with less PVR. PVR is diagnosed using echocardiography, aortic angiogram with or without videodensitometry, haemodynamic parameters, or cardiac magnetic resonance. PVR can be treated using post-dilation, interventional treatment using a vascular plug, or implantation of a second device. Successful post-dilation depends on balloon size which should at least be equal to or &amp;gt;95% of the mean annulus diameter. Implantation of a second device to reduce PVR is successful in ∼90% of cases, either through lengthening of the sealing skirt in case of inadequate position or through further expansion of the index device. Implantation of a vascular plug can successfully reduce PVR and reduce mortality.
Visual Attention in Crisis
Authors: Ruth Rosenholtz
Journal: Behavioral and Brain Sciences (2024)

Research on visual attention has uncovered significant anomalies, and some traditional methods may have inadvertently probed peripheral vision rather than attention. Vision science needs to rethink visual attention from the ground up. To facilitate this, for a year I banned the word "attention" in my lab. This constraint promoted a more precise discussion of attention-related phenomena, capacity limits, and mechanisms. The insights gained lead me to challenge attributing to "attention" those phenomena that can be better explained by perceptual processes, are predictable by an ideal observer model, or that otherwise may not require an additional mechanism. I enumerate a set of critical phenomena in need of explanation. Finally, I propose a unifying theory in which all perception results from performing a task, and tasks face a limit on complexity.
Diagnosis of common health conditions among autistic adults in the UK: evidence from a matched cohort study
Authors: Elizabeth O'Nions, Jude Brown, Joshua E.J. Buckman, Rebecca Charlton, Claudia Cooper, Céline El Baou, Francesca Happé, Sarah Hoare, Dan Lewer, Jill Manthorpe, Douglas G.J. McKechnie, Marcus Richards, Rob Saunders, Will Mandy, Joshua Stott
Journal: The Lancet Regional Health - Europe (2024)
A commentary on ““Dumpling suture method” versus traditional suture method of protective loop ileostomy in laparoscopic anterior rectal resection with specimen extraction through stoma incision: a retrospective comparative cohort study”
Authors: Qianqian Huang, Qiang Hu
Journal: International Journal of Surgery (2024)

Department of general surgery,Tongde Hospital of Zhejiang Province, 234 Gucui RD, Hangzhou, 310012, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of general surgery,Tongde Hospital of Zhejiang Province, 234 Gucui RD, Hangzhou, 310012, China. Tel: +86-15700190534. E-mail address: [email protected] (Q. Hu). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A commentary on “concerns regarding “metabolic syndrome and surgical complications: A systematic review and meta-analysis of 13 million individuals”
Authors: Yuquan Chen, Yanwei You, Qi Zhang, Qiang Cao
Journal: International Journal of Surgery (2024)

aSchool of Public Health and Preventive Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash University, Level 1, 553 St Kilda Road, Melbourne, Victoria 3004, Australia bDivision of Sports Science & Physical Education, Tsinghua University, Beijing 100084, China cKunming University of Science and Technology, Kunming 650093, China dSchool of Pharmacy, Macau University of Science and Technology, Macau 999078, China Yuquan Chen, Yanwei You, Qi Zhang These authors have contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Tel.: +86-191-6886-3889; Fax: +86-853-6886-3889. E-mail address: [email protected] (Qiang Cao). This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0/
Enhancing the understanding of association between breast-conserving surgery with a lower incidence of suicide among females with breast cancer
Authors: ZuJun Wen
Journal: International Journal of Surgery (2024)

Department of pharmacy, Heyuan People's Hospital, Heyuan, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: Department of pharmacy, Heyuan People's Hospital, No.733 Wenxiang Road, Heyuan City, Guangdong Province, PR China. E-mail address: [email protected] (Z.J. Wen). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A commentary on ‘Trends and benefits of early hip arthroplasty for femoral neck fracture in China: a national cohort study’
Authors: Kuangying Xu, Xiaoang Ye, Lianguo Wu
Journal: International Journal of Surgery (2024)

aThe Second Clinical Medical College of Zhejiang Chinese Medical University bDepartment of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: The Second Affiliated Hospital of Zhejiang Chinese Medical University, 318 Chaowang Road, Gongshu District, Hangzhou, Zhejiang 310005, People's Republic of China. E-mail: [email protected] (L. Wu). This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0/
Impact of duodenum-preserving pancreatic head resection and pancreatoduodenectomy on postoperative diarrhea: insights from trial sequential analysis
Authors: Dan-Na Xie, Bao-Lin Qian
Journal: International Journal of Surgery (2024)

aThe First Clinical Medical College of Lanzhou University, Lanzhou 730000, China bDepartment of Hepatobiliary Surgery, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Hepatobiliary Surgery, Affiliated Hospital of Southwest Medical University, No.25 Taiping Street, Jiangyang District, Luzhou City, Sichuan Province, China. Tel: +0830-3165200. E-mail address: [email protected] (B.-L. Qian). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
A commentary on’A new designed full process coverage robot-assisted total hip arthroplasty: A multicenter randomized clinical trial’
Authors: Zheng Yan, Yan Xu, Lianguo Wu
Journal: International Journal of Surgery (2024)

aThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China bZhejiang Chinese Medical University School of Nursing, Hangzhou, Zhejiang, People's Republic of China cDepartment of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang,People's Republic of China Zheng Yan and Yan Xu contributed equally to this work and share first authorship. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Postal address: The Second Affiliated Hospital of Zhejiang Chinese Medical University, 318 Chaowang Road, Gongshu District, Hangzhou, Zhejiang 310005, People's Republic of China. E-mail address: [email protected] (Lianguo Wu). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
A comment on “Efficacy of mitral valve repair in combination with coronary revascularization for moderate ischaemic mitral regurgitation: a systematic review and meta-analysis of randomized controlled trials”
Authors: Jiayun Zheng, Zeru Chen
Journal: International Journal of Surgery (2024)

aThe First Clinical Medical School, Guangzhou Medical University, Guangzhou, Guangdong, China bThe Second Clinical Medical School, Guangzhou Medical University, Guangzhou, Guangdong, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Correspondence: E-mail address: [email protected] (J. Zheng). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A commentary on “The value of cholinesterase inhibitors for improving neuropsychiatric and functional assessment scores in patients with alzheimer disease: a systematic review and meta-analysis of on placebo-controlled RCTs”
Authors: Yawen He, Zhiyang Jiang, Yonghua Zhang
Journal: International Journal of Surgery (2024)

Hangzhou TCM Hospital of Zhejiang Chinese Medical University Yawen He and Zhiyang Jiang contributed equally to this work and share first authorship Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Hangzhou TCM Hospital of Zhejiang Chinese Medical University, 453 Stadium Road, West Lake District, Hangzhou, Zhejiang 310007, People's Republic of China. E-mail address: [email protected] (Y. Zhang). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Letter to editor: Effect of pre-transplant viral therapy on post-transplant hepatitis B virus reactivation in patients with hepatitis B-related hepatocellular carcinoma
Authors: Shengke Zhang, Shangke Huang, Guanhu Yang, Hao Chi
Journal: International Journal of Surgery (2024)

aDepartment of Clinical Medicine, Southwest Medical University, Luzhou 646000, China bDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China cDepartment of Specialty Medicine, Ohio University, Athens 45701, USA Shengke Zhang, Shangke Huang, Guanhu Yang: These authors have contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Southwest Medical University, CHINA. E-mail address: [email protected] (H. Chi). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Letter to the editor: Comparison of postoperative glomerular filtration rate between robot-assisted partial nephrectomy (RAPN) and open partial nephrectomy (OPN)
Authors: Xuancheng Zhou, Bo Li, Guanhu Yang, Hao Chi
Journal: International Journal of Surgery (2024)

aClinical Medical College, Southwest Medical University, Luzhou 646000, China bDepartment of General Surgery, The Affiliated Hospital of Southwest Medical University, Sichuan, China cAcademician (Expert) Workstation of Sichuan Province, Metabolic Hepatobiliary and Pancreatic Diseases Key Laboratory of Luzhou City, The Affiliated Hospital of Southwest Medical University, Sichuan, China dDepartment of Specialty Medicine, Ohio University, Athens 45701, OH, United States. Assistance with the study: none. Financial support and sponsorship: The study was approved by the projects of the Science and Technology Department of Sichuan Province (2023YFQ0101) and chen xiao-ping foundation for the development of science and technology of hubei province (CXPJJH123003-008). Xuancheng Zhou, Bo Li, Guanhu Yang These authors have contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Clinical Medical College, Southwest Medical University, Luzhou 646000, China. E-mail address: [email protected] (H. Chi). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A commentary on “Timing of restoration of bowel continuity after decompressing stoma, in left-sided obstructive colon cancer: a nationwide retrospective cohort”
Authors: Tingfen Han, Shuai Liu
Journal: International Journal of Surgery (2024)

aDepartment of Traditional Chinese Medicine, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Taizhou, People's Republic of China bDepartment of Gastrointestinal Surgery, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Taizhou, People's Republic of China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: Department of Gastrointestinal Surgery, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Taizhou 317000, People's Republic of China. Tel.:+86 0576-85120120. fax: +86 0576 85190165. E-mail address: [email protected] (S. Liu). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Identification and validation of the surface proteins FIBG, PDGF-β, and TGF-β on serum extracellular vesicles for non-invasive detection of colorectal cancer: experimental study
Authors: Zhijian Huang, Cuncan Deng, Caiqi Ma, Guirong He, Jian Tao, Lijun Zhang, Xiaoyun Hu, Yanfang Mo, Lumei Qiu, Ningfang Zhang, Chuanghua Luo, Shan Xing, Jinye Xie, Haofan Yin
Journal: International Journal of Surgery (2024)

The absence of non-invasive biomarkers for the early diagnosis of colorectal cancer (CRC) has contributed to poor prognosis. Extracellular vesicles (EVs) have emerged as promising candidates for cancer monitoring using liquid biopsy. However, the complexity of EVs isolation procedures and the absence of clear targets for detecting serum-derived EVs have hindered the clinical application of EVs in early CRC diagnosis.
A commentary on “Current management of avascular necrosis of the metacarpal head: a comprehensive literature review”
Authors: Liyun Jiang, Zongping Xiao, Teng Chen, Rui Jiang
Journal: International Journal of Surgery (2024)

aDepartment of Orthopedics and Traumatology (Ward 3), Jiujiang Hospital of Traditional Chinese Medicine, Jiangxi, China, 332005 bDepartment of Orthopedics and Traumatology (Ward 3), Jiujiang Hospital of Traditional Chinese Medicine, Jiangxi, China, 332005 cDepartment of Orthopedics and Traumatology (Ward 3), Jiujiang Hospital of Traditional Chinese Medicine, Jiangxi, China, 332005 dDepartment of Orthopedics and Traumatology (Ward 3), Jiujiang Hospital of Traditional Chinese Medicine, Jiangxi, China, 332005 Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Orthopedics and Traumatology (Ward 3), Jiujiang Hospital of Traditional Chinese Medicine, Jiangxi, China, 332005. E-mail address: [email protected] (T. Chen). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Letter to the Editor about “Preoperative duration of type 2 diabetes mellitus and remission after Roux-en-Y gastric bypass: A single center long-term cohort study”
Authors: Yuhan Zhu, Qi Zhang, Yuquan Chen, Yuzhi Gong
Journal: International Journal of Surgery (2024)

aSchool of Nursing,Tongji Medical College of Huazhong University of Science and Technology,Wuhan,China,430077 bDepartment of ophthalmology,Kaifeng Eye Hospital ,Kaifeng Central Hospital,Kaifeng,China.475000 cSchool of Medicine, Macau University of Science and Technology, 999078, Macau, China dDepartment of Epidemiology & Preventive Medicine Alfred Hospital, Faculty of Medicine, Nursing & Health Sciences, Monash University, Melbourne, Victoria, Australia eDepartment of Nursing,Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China,430077 Yuhan Zhu, Qi Zhang, Yuquan Chen These authors contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Nursing,Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China,430077. E-mail address: [email protected] (Y. Gong). This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0/
A commentary on “circulating metabolic markers after surgery identify patients at risk for severe postoperative complications: a prospective cohort study in colorectal cancers”
Authors: Yajie Wang, Huan Deng, Yisheng Pan
Journal: International Journal of Surgery (2024)

Department of Gastrointestinal Surgery, Peking University First Hospital Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Gastrointestinal Surgery, Peking University First Hospital, No.8 Xishku Street, Xicheng District, Beijing, China. E-mail address: [email protected] (Y. Pan). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/