tbuckley/cabot-search huggingface dataset:
Correspondence on Letter regarding “Comprehensive Analysis of Transcriptomic Biomarkers for Predicting Response to Atezolizumab Plus Bevacizumab Immunotherapy in Hepatocellular Carcinoma.”
Authors: Sung Hwan Lee, Sun Young Yim, Ji Hoon Kim, Sunyoung S Lee, Ahmed O Kaseb, Peng Wei, Ju-Seog Lee
Journal: Clinical and Molecular Hepatology (2024)
USP29 alleviates the progression of MASLD by stabilizing ACSL5 through K48 deubiquitination
Authors: Sha Hu, Zhouxiang Wang, Kun Zhu, Hongjie Shi, Fang Qin, Tuo Zhang, Song Tian, Yanxiao Ji, Jianqing Zhang, Juanjuan Qin, Zhigang She, Xiaojing Zhang, Peng Zhang, Hongliang Li
Journal: Clinical and Molecular Hepatology (2024)

Metabolic dysfunction-associated fatty liver disease (MASLD) is a chronic liver disease characterized by hepatic steatosis. Ubiquitin-specific proteinase 29 (USP29) plays pivotal roles in hepatic ischemia‒reperfusion injury and hepatocellular carcinoma, but its role in MASLD remains unexplored. Therefore, the aim of this study was to reveal the effects and underlying mechanisms of USP29 in MASLD progression.
Maternal Blood Cell-Free RNA Signatures in Fetus With Congenital Heart Disease
Authors: Matthew Alonzo, Zhaohui Xu, Yang Yu, Shiqiao Ye, Cankun Wang, Jerry Wang, Megan McNutt, Jakob Bering, Qin Ma, Karen Texter, Vidu Garg, Ming-Tao Zhao
Journal: Circulation Research (2024)
Optimal tacrolimus levels for reducing CKD risk and the impact of intrapatient variability on CKD and ESRD development following liver transplantation
Authors: Soon Kyu Lee, Ho Joong Choi, Young Kyoung You, Pil Soo Sung, Seung Kew Yoon, Jeong Won Jang, Jong Young Choi
Journal: Clinical and Molecular Hepatology (2024)

This study aimed to identify the risk factors for chronic kidney disease (CKD) and end-stage renal disease (ESRD) following liver transplantation (LT), with a specific focus on tacrolimus levels and intrapatient variability (IPV).
LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA/Rock/Myosin II pathway
Authors: Xuening Pang, Tongling Zhang, Jiazheng Li, Liqun Yu, Zhibo Liu, Yuchen Liu, Li Li, Liming Cheng, Rongrong Zhu
Journal: Biomaterials (2024)
Concurrent Intracranial and Spinal Dural Metastases Demonstrated by 68Ga-DOTATATE PET/CT With Negative 123I-MIBG SPECT/CT in a Pediatric Neuroblastoma Patient
Authors: Haizhou Qiao, Siqi Li, Yanfeng Xu, Wei Wang, Jigang Yang
Journal: Clinical Nuclear Medicine (2024)

Abstract Contrast enhancement MRI of the brain and spine showed abnormal enhancement in intracranial and spinal dural lesions in a 6-year-old boy with high-risk neuroblastoma, suggesting the possibility of dural metastases. 123 I-MIBG SPECT/CT did not show any abnormal MIBG accumulation in these lesions. However, 68 Ga-DOTATATE PET/CT showed obvious DOTATATE uptake in these metastatic lesions. Surgical pathology confirmed the diagnosis of intracranial dural metastasis. Concurrent intracranial and spinal dural metastases from neuroblastoma demonstrated by 68 Ga-DOTATATE PET/CT with negative 123 I-MIBG SPECT/CT have not been reported previously.
Multiple Myeloma Presented With Testicular Involvement at Initial Diagnosis on 18F-FDG PET/CT
Authors: Nuh Filizoglu, Selin Kesim
Journal: Clinical Nuclear Medicine (2024)

Extramedullary involvement is a rare presentation of multiple myeloma (MM), and testicular involvement is even rarer. Testicular involvement associated with poor prognosis and orchiectomy is necessary for definitive diagnosis. Although 18 F-FDG PET/CT is well-known for its ability to detect extramedullary involvement and assess treatment response in MM, testicular involvement of MM on 18 F-FDG PET/CT at initial diagnosis has not yet been reported. Herein, we present a rare case of MM with testicular involvement at initial diagnosis.
Diffuse Uptake of 68Ga-Pentixafor in the Breasts During the Ovulatory Phase in a Patient With SAPHO Syndrome
Authors: Tingting Xu, Zibei Wan, Yue Chen
Journal: Clinical Nuclear Medicine (2024)

Abstract We report a case of a woman with SAPHO syndrome who exhibited increased tracer uptake in the sternal angle on a 99m Tc-MDP bone scan. This patient was enrolled in a 68 Ga-pentixafor PET/CT trial for inflammatory diseases. The PET/CT showed no abnormal tracer uptake in the sternal angle. Unexpectedly, diffuse uptake of 68 Ga-pentixafor was observed in both breasts, which might be due to hormonal stimulation because the woman underwent the 68 Ga-pentixafor PET/CT scan during the ovulatory phase.
Renal Cell Carcinoma With Tumor Thrombus Extending Into the Inferior Vena Cava and the Right Atrium Demonstrated by 68Ga-DOTATATE PET/CT
Authors: Nuh Filizoglu, Salih Ozguven
Journal: Clinical Nuclear Medicine (2024)

Abstract Approximately 10% of all renal cell carcinoma (RCC) patients develop a venous tumor thrombus, a major negative prognostic factor. Surgical excision is commonly required for RCC patients with tumor thrombus. Accurate preoperative diagnosis and assessment of tumor thrombus level is vital because the level of thrombus may influence treatment decisions. MRI, contrast-enhanced CT, 18 F-FDG PET/CT, and 68 Ga-PSMA PET/CT have been used to diagnose and evaluate the extent of tumor thrombus in RCC. However, no case of RCC with inferior vena cava tumor thrombus showing 68 Ga-DOTATATE uptake has been reported yet. Herein, we report a case of metastatic RCC with tumor thrombus in the inferior vena cava on 68 Ga-DOTATATE PET/CT.
Increased Uptake of 68Ga-DOTA-IBA in Multiple Subcutaneous Metastases of Prostate Cancer
Authors: Huipan Liu, Yuhong Liu, Wei Wang, Xiaoyan Shang, Yue Chen
Journal: Clinical Nuclear Medicine (2024)

Abstract Subcutaneous metastases are rare in prostate cancer. Herein, we present a case of a 66-year-old man with prostate cancer, who underwent 68 Ga-labeled DOTA-ibandronic acid ( 68 Ga-DOTA-IBA) PET/CT to explore the possibility of 177 Lu-DOTA-IBA treatment. 68 Ga-DOTA-IBA PET/CT demonstrated intensely increased uptake in the multiple osteoblastic bone metastases. Unexpectedly, 68 Ga-DOTA-IBA uptake in multiple subcutaneous metastases was also noted.
Intratracheal Ectopic Thyroid Tissue Mimicking a Subglottic Mass in a Patient With Thyroid Follicular Carcinoma on SPECT/CT
Authors: Nur Aydinbelge-Dizdar, Alev Cinar, Ozlem Ozmen, Semra Demirtas Senlik
Journal: Clinical Nuclear Medicine (2024)

Intratracheal ectopic thyroid tissue is an extremely rare condition with limited cases reported in the literature. It can be asymptomatic or present with symptoms such as dysphagia, bleeding, dysphonia, dyspnea, and a sensation of a foreign body in the throat, depending on its localization. Due to its various clinical presentations, it poses a diagnostic dilemma. Herein, we aimed to present the contribution of thyroid scintigraphy and SPECT/CT to the diagnosis and management of a case with follicular carcinoma in the orthotopic thyroid gland as well as an ectopic intratracheal thyroid causing cough and airway obstruction mimicking a subglottic mass.
Superior Identification of Metastatic Lesions by 68Ga-FAPI-46 PET/CT Than 18F-FDG PET/CT in Hepatic Solitary Fibrous Tumor
Authors: Kaili Fu, Liang Zhao, Jiayu Cai, Lingyu Yu, Haojun Chen
Journal: Clinical Nuclear Medicine (2024)

Abstract Solitary fibrous tumors (SFTs) are fibroblast tumors that occur mainly in the pleura. Hepatic SFT with skeleton metastases was rarely documented. In this case, we report the contrast-enhanced CT, 18 F-FDG, and 68 Ga-FAPI-46 PET/CT findings of a rare hepatic SFT with bone metastases. 68 Ga-FAPI-46 PET/CT showed much higher tumor-to-background contrast of hepatic tumors and revealed more metastatic bone lesions than 18 F-FDG PET/CT. This case demonstrated the superiority of 68 Ga-FAPI-46 PET/CT over 18 F-FDG for identifying metastatic lesions in malignant SFTs. This observation may add information on the benefit of FAPI PET/CT in SFT staging.
Value of 68Ga-DOTATATE PET/CT in Follow-up of Renal Cell Carcinoma With Multiple Atypical Metastatic Sites
Authors: Nuh Filizoglu, Salih Ozguven, Tunc Ones, Halil Turgut Turoglu, Tanju Yusuf Erdil
Journal: Clinical Nuclear Medicine (2024)

Abstract The development of late metastatic recurrence after nephrectomy is a well-known characteristic of renal cell carcinoma (RCC). Correct diagnosis is often challenging due to the long time between primary tumor excision and the development of metastases. 68 Ga-DOTATATE PET/CT has the potential to be employed in the follow-up of RCC, because RCC expresses somatostatin receptors. However, limited cases have been reported demonstrating 68 Ga-DOTATATE uptake in the metastases of RCC. Herein, we describe a unique case of RCC with multiple atypical metastatic sites, emphasizing the usefulness of 68 Ga-DOTATATE PET/CT in the evaluation and follow-up of patients with RCC.
Positive 68Ga-FAPI-04 PET/MRI and Negative 18F-FDG PET/CT Imaging in Incidental Appendiceal Goblet Cell Adenocarcinoma
Authors: Yu Sun, Haiyan Wang, Xing Chen, Weilun Wang, Jun Zhao
Journal: Clinical Nuclear Medicine (2024)

Abstract A 70-year-old woman presented with left ovarian mass and thickened peritoneum. 18 F-FDG PET/CT showed no significant FDG-avid in the whole body. 68 Ga-FAPI-04 demonstrated abnormally high FAPI uptake in the ileocecal region, left ovarian lesion, and thickened peritoneum. The postoperative pathology confirmed the appendiceal goblet cell adenocarcinoma. This case highlights the superior and innovative diagnostic role of 68 Ga-FAPI-04 in appendiceal goblet cell adenocarcinoma and its metastases.
Detection and Response Evaluation of Extramedullary and Medullary Blast Crisis in Chronic Myeloid Leukemia on 18F-FDG PET/CT
Authors: Abhishek Behera, Meghana Prabhu, Gaurav Khanna, Shikhar Sawhney, Pravas Chandra Mishra
Journal: Clinical Nuclear Medicine (2024)

Abstract FDG PET/CT imaging is usually not routinely undertaken in patients of chronic myeloid leukemia (CML). We present a case of CML on tyrosine kinase inhibitor treatment with disease control indicated by BCR-ABL1 quantitative reverse transcription–polymerase chain reaction, who underwent PET/CT for evaluation of recent onset vision deterioration with subretinal exudates on ophthalmological examination. PET CT detected FDG-avid sinonasal thickening and bilateral marrow lesions. These lesions on histopathological sampling, examination revealed extramedullary and intramedullary CML blast crisis. Patient was then treated with steroids and change of tyrosine kinase inhibitor for the CML blast crisis. FDG PET/CT done subsequently was able to demonstrate morphological and metabolic response in the lesions.
Specifically Decreased Thalamic Blood Flow Following COVID-19 Infection
Authors: Taiki Matsubayashi, Kota Yokoyama, Ukihide Tateishi, Takanori Yokota, Nobuo Sanjo
Journal: Clinical Nuclear Medicine (2024)

Abstract Although long COVID refers to numerous COVID-19–related symptoms after infection, including depression, fatigue, anosmia, sleep disturbances, and brain fog, the etiology of long COVID remains largely unknown. A 41-year-old woman presented with a 3-week history of complete insomnia without drowsiness throughout the day after contracting COVID-19. SPECT using N -isopropyl-p-[ 123 I] iodoamphetamine showed a significant regional cerebral blood flow reduction in the bilateral thalamus. We diagnosed her as having insomnia accompanied by thalamic hypoperfusion related to COVID-19 infection. To our knowledge, this is the first case of reduced regional cerebral blood flow specifically confined to the thalamus.
Lenticulostriatal Ischemia Shows Relevant SSTR Expression on PET/CT Imaging Using the Novel SSTR-Targeting Peptide 18F-SiTATE
Authors: Sophie C. Kunte, Lena M. Unterrainer, Wolfgang G. Kunz, Michael Winkelmann, Simon Lindner, Klaus Jurkschat, Carmen Wängler, Björn Wängler, Ralf Schirrmacher, Peter Bartenstein, Claus Belka, Christian Schichor, Nathalie L. Albert, Marcus Unterrainer
Journal: Clinical Nuclear Medicine (2024)

A 64-year-old woman with meningioma presented with left-sided lenticulostriatal ischemia following craniotomy and debulking of a sphenoid wing meningioma. For subsequent radiotherapy planning, an SSTR-targeted PET/CT using the novel ligand 18 F-SiTATE was performed 2.5 months thereafter. The meningioma remnants showed transosseous, intrasellar, and perivascular extension around the internal carotid artery with strong SSTR expression. Moreover, there was focal 18 F-SiTATE uptake in the left caudate and corresponding contrast enhancement due to postischemic blood-brain barrier disruption and reactive SSTR expression. Therefore, increased cortical or subcortical SSTR PET signal may be related to ischemic changes even in the subacute stage after initial stroke.
Integrated 68Ga-Pentixafor and 68Ga-FAPI-04 PET/MR for Diagnosing Adrenal Aldosterone-Producing Adenoma and Accessory Splenic Nodules
Authors: Jie Ding, Weilun Wang, Xing Chen, Zhiwen You, Jun Zhao
Journal: Clinical Nuclear Medicine (2024)

Abstract A 57-year-old man with primary aldosteronism exhibited multiple nodules in the left adrenal, pancreatic tail, and splenic region. The left adrenal nodule showed positive 68 Ga-pentixafor and negative 68 Ga-FAPI-04 uptake, suggesting an aldosterone-producing adrenal adenoma. The nodule in the pancreatic tail exhibited high 68 Ga-pentixafor and low 68 Ga-FAPI-04 uptake, similarity with the nodule in splenic region, indicating accessory splenic nodule. Postoperative pathology confirmed an adrenal cortical adenoma and an accessory splenic nodule in the pancreas. This case underscores the complementary role of 68 Ga-pentixafor and 68 Ga-FAPI-04 PET/MR in diagnosing complex adrenal and pancreatic pathologies.
Joker Sign After Drooling Radioactive Saliva
Authors: MinJeong Kim, Yeon-Hee Han, Hwan-Jeong Jeong, Jae Seok Jeong, Seok Tae Lim
Journal: Clinical Nuclear Medicine (2024)

Abstract A 28-year-old man underwent high-dose radioactive iodine therapy after total thyroidectomy due to papillary thyroid carcinomas. After 2 weeks, a linear reddish line was observed extending from the right corner of the mouth to the cheek, resembling the appearance of the Joker. Through a detailed interview, it was determined that the patient had developed radiation dermatitis because of radioactive saliva drooling while sleeping on one side. Although this is expected to be infrequent, educating patients on avoiding saliva contact with the skin during and after radioactive iodine therapy is crucial due to the potential skin damage and cancer risk.
68Ga-FAPI PET in Visualizing Acute Ischemic Stroke at Risk of Hemorrhagic Transformation
Authors: Jahae Kim, Hye-Jin Park, Sang-Geon Cho, Ki-Seong Park, Kang-Ho Choi
Journal: Clinical Nuclear Medicine (2024)

Abstract Hemorrhagic transformation is a serious complication of ischemic stroke, which occurs at a rate of between 18% and 42%. 68 Ga-FAPI PET can visualize acute cerebral infarction at risk of hemorrhagic transformation in the brain. We report a case of 68 Ga-FAPI PET imaging in a patient with recurrent ischemic stroke. 68 Ga-FAPI PET imaging revealed FAPI uptake in acute ischemic stroke with hemorrhagic transformation, but did not in some acute infarction and chronic infarction without hemorrhagic transformation. These findings suggest potential role of 68 Ga-FAPI PET in the evaluation of acute ischemic stroke with the risk of hemorrhagic transformation.
Climate injustice: lessons from the Philippines' jeepney modernisation programme
Authors: John Jamir Benzon R Aruta, Romiane Grace V Gonzales, Gaye Justinia R Delos Santos, Eliza Faye B Lumanog, Alexandra S Chew, Aenghel Marie D Bonoan, Ginger Erin Swa
Journal: The Lancet Planetary Health (2024)
acFibroMASH index for the diagnosis of fibrotic MASH and prediction of liver-related events: An international multicenter study
Authors: Gong Feng, Ferenc E Mózes, Dong Ji, Sombat Treeprasertsuk, Takeshi Okanoue, Toshihide Shima, Huiqing Liang, Emmanuel Tsochatzis, Jinjun Chen, Jörn M Schattenberg, Christian Labenz, Sanjiv Mahadeva, Wah Kheong Chan, Xiaoling Chi, Adèle Delamarre, Victor de Lédinghen, Salvatore Petta, Elisabetta Bugianesi, Hannes Hagström, Jérôme Boursier, José Luis Calleja, George Boon-Bee Goh, Rocio Gallego-Durán, Arun J Sanyal, Jian-Gao Fan, Laurent Castéra, Michelle Lai, Stephen A Harrison, Manuel Romero-Gomez, Seung Up Kim, Yongfen Zhu, Geraldine Ooi, Junping Shi, Masato Yoneda, Atsushi Nakajima, Jing Zhang, Monica Lupsor-Platon, Bihui Zhong, Jeremy F L Cobbold, Chun-Yan Ye, Peter J Eddowes, Philip Newsome, Jie Li, Jacob George, Fangping He, Myeong Jun Song, Hong Tang, Yuchen Fan, Jidong Jia, Liang Xu, Su Lin, Yiling Li, Zhonghua Lu, Yuemin Nan, Junqi Niu, Xuebing Yan, Yongjian Zhou, Chenghai Liu, Hong Deng, Qing Ye, Qing-Lei Zeng, Lei Li, Jing Wang, Song Yang, Huapeng Lin, Hye Won Lee, Terry Cheuk-Fung Yip, Céline Fournier-Poizat, Grace Lai-Hung Wong, Grazia Pennisi, Angelo Armandi, Wen-Yue Liu, Ying Shang, Marc de Saint-Loup, Elba Llop, Kevin Kim Jun Teh, Carmen Lara-Romero, Amon Asgharpour, Sara Mahgoub, Mandy Sau-Wai Chan, Clemence M Canivet, Fanpu Ji, Yongning Xin, Jin Chai, Zhiyong Dong, Giovanni Targher, Christopher D Byrne, Na He, Man Mi, Feng Ye, Vincent Wai-Sun Wong, Michael Pavlides, Ming-Hua Zheng
Journal: Clinical Gastroenterology and Hepatology (2024)
Protective and Damaging Mechanisms of Neuromelanin‐Like Nanoparticles and Iron in Parkinson's Disease
Authors: Lizhu Liu, Tianying Wang, Hao Zhou, Jinyang Zheng, Qiang Liu, Wei Wang, Xinxin Liu, Xiuming Zhang, Dongtao Ge, Wei Shi, Yanan Sun
Journal: Advanced Healthcare Materials (2024)

Abstract Parkinson's disease (PD) pathology speculates that neuromelanin (NM) and iron ions play a significant role in physiological and pathological conditions of PD. Because the difficult accessibility of NM has limited targeted research, synthetic melanin‐like nanoparticles have been used to instead. In this report, the eumelanin and pheomelanin‐like polydopamine (PDA) nanoparticles are prepared that can be used to simulate natural NM with or without chelating iron ion and studied the redox effects in vitro and in vivo on neuronal cells and PD. The synthetic pheomelanin‐like PDA nanoparticles have much stronger redox activity than eumelanin‐like PDA nanoparticles without or with iron ion. They can protect neurons by scavenging reactive oxygen species (ROS), while cause neuronal cell death and PD due to excessive binding of iron ions. This work provides new evidence for the relationship among two structural components of NM and iron in PD as well as displays the different effects on the roles of eumelanin and pheomelanin in redox activity under physiological or pathological conditions, which provide a new effective choice for cellular and animal models of PD and offer theoretical guidance for targeted treatment and mechanism research on PD.
Interleukin‐5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils
Authors: Kathleen M. Buchheit, Dominick Shaw, Geoffrey Chupp, Lauri Lehtimaki, Enrico Heffler, Tricia Finney‐Hayward, James Zangrilli, Justin Kwiatek, Salman Siddiqui, Florence Roufosse, Andrew Thamboo, Nicholas West, Anna Vichiendilokkul, Peter W. Hellings, Anju Peters, Peter H. Howarth
Journal: Allergy (2024)

Abstract Interleukin (IL)‐5 is the key cytokine in the maturation, activation, proliferation, migration and survival of eosinophils, which are key effector cells in many upper and lower airway diseases. Through its effects on eosinophils, IL‐5 indirectly contributes to various pathophysiological processes including tissue damage, repair and remodelling. Understanding the importance of IL‐5 in eosinophil‐associated diseases led to the development of anti‐IL‐5 therapies, which provide clinical benefits across a range of conditions. However, recent evidence suggests that eosinophil‐depletion alone may not account for all of the therapeutic effects of anti‐IL‐5 therapy and that IL‐5 may also contribute to disease independently of its effects on eosinophils. Indeed, evidence from ex vivo studies and targeted therapy in vivo demonstrates that IL‐5 and its inhibition affects a much broader range of cells beyond eosinophils, including epithelial cells, plasma cells, mast cells, basophils, neutrophils, type 2 innate lymphoid cells, T regulatory cells and fibroblasts. This review will provide an update on the evidence supporting the breadth of IL‐5 biology relevant to disease pathogenesis beyond eosinophil‐associated inflammation, where there is a need for additional insight, and the clinical implications of a more central role of IL‐5 in type 2 inflammation.
Inherited Predispositions to Myeloid Neoplasms: Pathogenesis and Clinical Implications
Authors: Yen-Chun Liu, Mohammad K. Eldomery, Jamie L. Maciaszek, Jeffery M. Klco
Journal: Annual Review of Pathology Mechanisms of Disease (2024)

Myeloid neoplasms with and without preexisting platelet disorders frequently develop in association with an underlying germline predisposition. Germline alterations affecting ANKRD26, CEBPA, DDX41, ETV6, and RUNX1 are associated with nonsyndromic predisposition to the development of myeloid neoplasms including acute myeloid leukemia and myelodysplastic syndrome. However, germline predisposition to myeloid neoplasms is also associated with a wide range of other syndromes, including SAMD9/9L associated predisposition, GATA2 deficiency, RASopathies, ribosomopathies, telomere biology disorders, Fanconi anemia, severe congenital neutropenia, Down syndrome, and others. In the fifth edition of the World Health Organization (WHO) series on the classification of tumors of hematopoietic and lymphoid tissues, myeloid neoplasms associated with germline predisposition have been recognized as a separate entity. Here, we review several disorders from this WHO entity as well as other related conditions with an emphasis on the molecular pathogenesis of disease and accompanying somatic alterations. Finally, we provide an overview of establishing the molecular diagnosis of these germline genetic conditions and general recommendations for screening and management of the associated hematologic conditions.
European Society of Intensive Care Medicine guidelines on end of life and palliative care in the intensive care unit
Authors: Jozef Kesecioglu, Katerina Rusinova, Daniela Alampi, Yaseen M Arabi, Julie Benbenishty, Dominique Benoit, Carole Boulanger, Maurizio Cecconi, Christopher Cox, Marjel van Dam, Diederik van Dijk, James Downar, Nikolas Efstathiou, Ruth Endacott, Alessandro Galazzi, Fiona van Gelder, Rik T Gerritsen, Armand Girbes, Laura Hawyrluck, Margaret Herridge, Jan Hudec, Nancy Kentish-Barnes, Monika Kerckhoffs, Jos M Latour, Jan Malaska, Annachiara Marra, Stephanie Meddick-Dyson, Spyridon Mentzelopoulos, Mervyn Mer, Victoria Metaxa, Andrej Michalsen, Rajesh Mishra, Giovanni Mistraletti, Margo van Mol, Rui Moreno, Judith Nelson, Andrea Ortiz Suñer, Natalie Pattison, Tereza Prokopova, Kathleen Puntillo, Kathryn Puxty, Samah Al Qahtani, Lukas Radbruch, Emilio Rodriguez-Ruiz, Ron Sabar, Stefan J Schaller, Shahla Siddiqui, Charles L Sprung, Michele Umbrello, Marco Vergano, Massimo Zambon, Marieke Zegers, Michael Darmon, Elie Azoulay
Journal: Intensive Care Medicine (2024)
A 9-Year-Old Child With a Large Thoracic Mass
Authors: Chenghao Chen, Jie Yu, Qi Zeng
Journal: JAMA (2024)

A healthy 9-year-old had 10 days of nonproductive cough without fever, wheeze, chest pain, or abdominal pain but with diminished breath sounds in the right lower lung field. Results of laboratory testing were unremarkable; computed tomography revealed a fat-density mass in the right anterior mediastinum. What is the diagnosis and what would you do next?