tbuckley/cabot-search huggingface dataset:
Diets intervene osteoporosis via gut-bone axis
Authors: Yuan-Wei Zhang, Pei-Ran Song, Si-Cheng Wang, Han Liu, Zhong-Min Shi, Jia-Can Su
Journal: Gut Microbes (2024)

Osteoporosis is a systemic skeletal disease that seriously endangers the health of middle-aged and older adults. Recently, with the continuous deepening of research, an increasing number of studies have revealed gut microbiota as a potential target for osteoporosis, and the research concept of the gut-bone axis has gradually emerged. Additionally, the intake of dietary nutrients and the adoption of dietary patterns may affect the gut microbiota, and alterations in the gut microbiota might also influence the metabolic status of the host, thus adjusting bone metabolism. Based on the gut-bone axis, dietary intake can also participate in the modulation of bone metabolism by altering abundance, diversity, and composition of gut microbiota. Herein, combined with emerging literatures and relevant studies, this review is aimed to summarize the impacts of different dietary components and patterns on osteoporosis by acting on gut microbiota, as well as underlying mechanisms and proper dietary recommendations.
Development of a novel treatment for pemphigus and confirmation of its efficacy: a randomized controlled trial of protein A immunoadsorption therapy
Authors: Takashi Hashimoto, Jun Yamagami
Journal: British Journal of Dermatology (2024)

Journal Article Corrected proof Development of a novel treatment for pemphigus and confirmation of its efficacy: a randomized controlled trial of protein A immunoadsorption therapy Get access Takashi Hashimoto, Takashi Hashimoto Conceptualization, Data curation, Validation, Writing - original draft Department of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan Correspondence: Takashi Hashimoto. Email: hashyt@gmail.com https://orcid.org/0000-0002-0144-3255 Search for other works by this author on: Oxford Academic Google Scholar Jun Yamagami Jun Yamagami Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, ljae008, https://doi.org/10.1093/bjd/ljae008 Published: 04 January 2024 Article history Received: 22 December 2023 Accepted: 31 December 2023 Published: 04 January 2024 Corrected and typeset: 30 January 2024
Effectiveness of longstanding exercise therapy compared with usual care for people with rheumatoid arthritis and severe functional limitations: a randomised controlled trial
Authors: Max M H Teuwen, Salima F E van Weely, Thea P M Vliet Vlieland, Maria A T van Wissen, Wilfred F Peter, Alfons A den Broeder, Dirkjan van Schaardenburg, Wilbert B van den Hout, Cornelia H M Van den Ende, Maaike G J Gademan
Journal: Annals of the Rheumatic Diseases (2024)

To compare the effectiveness of longstanding (>52 weeks), supervised exercise therapy with usual care in adults with rheumatoid arthritis (RA) and severe functional limitations.
Neonatal epidermolysis bullosa: a clinical practice guideline
Authors: Rebecca Saad, José Duipmans, Natalie Yerlett, Katie Plevey, Catherine McCuaig, William Woolfe, K Steinau, Jennifer Phillips, Nina Azzopardi, Kerry Thompson, Anna Carolina Ferreira da Rocha, Maurico Torres-Pradilla, Hagen Ott, Declan Patton, Zena Moore, Paul Murphy, Kattya Mayre-Chilton
Journal: British Journal of Dermatology (2024)

Abstract DEBRA International is undertaking a long-term initiative to develop clinical practice guidelines (CPGs) for epidermolysis bullosa (EB), to ­improve the clinical care of people living with EB. Current neonatal care is based on evidence, clinical expertise and trial and error, with collaboration between the EB specialist team, parent or carer and patient, and is dependent on the neonate’s individual presentation and type of EB. Early intervention based on research and clinical practice is needed to establish a foundation of knowledge to guide international practitioners to create and improve standards of care and to be able to work effectively with those newly diagnosed with EB. This CPG was created by an international panel with expertise working with persons with EB. The CPG focuses on neonatal care using a systematic review methodology covering four key areas: (i) diagnosis and parental psychosocial support; (ii) hospital management: medical monitoring, wound care and pain; (iii) feeding and nutrition; and (iv) discharge planning and EB education. These four areas highlight the importance of a multidisciplinary team approach, to provide a patient-specific holistic care model that incorporates the needs and wishes of the parents and carers. The Hospital Implementation Tool included promotes transfer of theory to clinical practice.
The elusive quest for causality in adiponectin’s bimodal relationship with cardiovascular disease: Mendelian randomization meets Janus
Authors: Jorge R Kizer
Journal: Cardiovascular Research (2024)

Journal Article Accepted manuscript The elusive quest for causality in adiponectin’s bimodal relationship with cardiovascular disease: Mendelian randomization meets Janus Get access Jorge R Kizer, MD, MSc Jorge R Kizer, MD, MSc Cardiology Section, San Francisco Veterans Affairs Health Care System, and Departments of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA Correspondence: Jorge R. Kizer, MD, MSc, Cardiology Section, San Francisco Veterans Affairs Health Care System, Mail Stop 111C, 4150 Clement Ave., San Francisco, CA 94904. Telephone: 415-221-4810. E-mail: Jorge.kizer@ucsf.edu https://orcid.org/0000-0001-9936-7803 Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, cvae001, https://doi.org/10.1093/cvr/cvae001 Published: 03 January 2024 Article history Received: 18 November 2023 Editorial decision: 29 November 2023 Accepted: 02 January 2024 Published: 03 January 2024
Blocking tumor-platelet crosstalk to prevent tumor metastasis via reprograming glycolysis using biomimetic membrane-hybridized liposomes
Authors: Jie Zhu, Rui Wang, Chenxiao Yang, Xinyue Shao, Yi Zhang, Jiazhen Hou, Yanrong Gao, Ante Ou, Meiwan Chen, Yongzhuo Huang
Journal: Journal of Controlled Release (2024)
Atopic dermatitis and cognitive function: a sibling comparison study among males in Sweden
Authors: Kelsi A Smith, Ayako Hiyoshi, Snieguole Vingeliene, Laura von Kobyletzki, Scott Montgomery
Journal: British Journal of Dermatology (2024)

A previous study indicated that atopic dermatitis (AD) was associated with better cognitive function in males during late adolescence. This association was examined among 2 021 369 males who had a medical examination and cognitive function testing during a military conscription assessment in late adolescence in Sweden. Sibling-comparison analysis to tackle confounding indicated that AD is associated with poorer cognitive function, suggesting AD in childhood is detrimental for the development of cognitive function.
For itch and insanity
Authors: Russ Cowper
Journal: British Journal of Dermatology (2024)

Journal Article For itch and insanity Get access Russ Cowper Russ Cowper Conceptualization, Writing - original draft, Writing - review & editing Long-term patient with psoriatic arthritis and psoriasis, Manchester, UKPsoriasis Association trustee, The Psoriasis Association, UK Email: jsanz@nyit.edu Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 190, Issue 4, April 2024, Page 568, https://doi.org/10.1093/bjd/ljad519 Published: 03 January 2024 Article history Received: 13 December 2023 Accepted: 17 December 2023 Published: 03 January 2024 Corrected and typeset: 24 January 2024
Atopic dermatitis and autism: tactile hypersensitivity impeding topical therapy use
Authors: Li Jie Helena Yoo, Nicholas Stefanovic, Richard E Watchorn
Journal: British Journal of Dermatology (2024)

This carer perspective article offers a unique insight into the lived experience of atopic dermatitis management in the setting of codiagnosed autism spectrum disorder (ASD). It delves into the profound effects of sensory reactivity in the setting of ASD, which poised a unique therapeutic challenge to management of this inflammatory skin disease. This article highlights the importance of an individualized approach and early initiation of systemic treatment when managing individuals with neuropsychiatric comorbidities.
Initial steps towards developing a predictive algorithm of disease progression for hidradenitis suppurativa: results from a Cox proportional hazard regression analysis on disease progression amongst a cohort of 335 Danish patients with hidradenitis suppurativa
Authors: Rune Kjærsgaard Andersen, Ole Pedersen, Liv Eidsmo, Gregor Jemec, Ditte Saunte
Journal: British Journal of Dermatology (2024)

Abstract Background Hidradenitis suppurativa (HS) is a chronic inflammatory and scarring disease with a wide spectrum of disease severity. The amount of scarring is proportional to the preceding tissue damage and poses a challenge to patients. Severe HS is most often treatment recalcitrant, but hypothetically avoidable through early biologic treatment. Early prediction of individual risk of disease progression is therefore essential for patient management. Objectives To investigate risk factors associated with disease progression and to design an algorithm capable of predicting disease ­progression. Methods A prospective cohort study of 335 Hurley III-naïve patients with HS, not treated with biologics, was followed for a median of 2 years. Potential risk factors covered basic demographics, HS anamnestic factors and clinical HS factors collected during physical examination. Two separate Cox proportional hazard regression (CPHR) analyses were conducted. A summated ‘progression score’ was calculated and used in the predictive algorithm of severe disease. Subsequent bootstrap sampling was used to validate the predictability of the predictive algorithm. Results The CPHR analysis of Transition to severe disease found that active smoking [hazard ratio (HR) 4.01, 95% confidence interval (CI) 1.71–9.40, P = 0.001]; body mass index (BMI) points &amp;gt; 25 at baseline (each point: HR 1.06, 95% CI 1.02–1.09, P &amp;lt; 0.001); active disease in 2 (HR 4.26, 95% CI 1.23–14.84, P = 0.02) and ≥ 3 areas (HR 6.54, 95% CI 1.89–22.72, P = 0.003) all constituted substantial risk factors. Conversely, the CPHR analysis of Disease progression did not yield results of clinical relevance. A ‘progression score’ of 3.04 was used as a threshold in the predictive algorithm of Transition to severe disease and achieved the following test specifics: sensitivity = 0.51, specificity = 0.86, positive predictive value = 0.50, negative predictive value = 0.86. Conclusions We found a disparity between factors increasing the risk of simple Disease progression and those increasing the risk of Transition to severe disease. For the latter, active smoking, BMI points &amp;gt; 25, active disease in 2 or ≥ 3 areas were all shown to be the clinically relevant factors that could be used to construct an algorithm that correctly predicted progression to severe HS in more than half of all instances.
Pre-mixing of omega-3 fatty acid-containing liposomes enhances the drug release rate and therapeutic efficacy of anticancer drugs loaded in liposomes
Authors: Eun-A Kim, Hyeon Gyeom Choi, Bao Loc Nguyen, Su-Jin Oh, Soo-Bin Lee, Sung Hun Bae, So Yeon Park, Jong Oh Kim, So Hee Kim, Soo-Jeong Lim
Journal: Journal of Controlled Release (2024)
68Ga-FAPI PET imaging monitors response to combined TGF-βR inhibition and immunotherapy in metastatic colorectal cancer
Authors: Ke Li, Wei Liu, Hang Yu, Jiwei Chen, Wenxuan Tang, Jianpeng Wang, Ming Qi, Yuyun Sun, Xiaoping Xu, Ji Zhang, Xinxiang Li, Weijian Guo, Xiaoling Li, Shaoli Song, Shuang Tang
Journal: Journal of Clinical Investigation (2024)

BACKGROUND. Improving and predicting tumor response to immunotherapy remains challenging. Combination therapy with a transforming growth factor-β receptor (TGF-βR) inhibitor that targets cancer associated fibroblasts (CAFs) is promising to enhance efficacy of immunotherapies. However, the effect of this approach in clinical trials is limited, requiring in vivo methods to better assess tumor responses to combination therapy.
Lower body mass and lower adiposity are associated with differential responses to two treatment strategies for rheumatoid arthritis
Authors: Joshua F Baker, James R ODell, Bryant R England, Jon T Giles, Jefferey A Newcomb, Michael D George, Geoffrey Thiele, Larry Moreland, S Louis Bridges, Jeffrey R Curtis, Ted R Mikuls
Journal: Annals of the Rheumatic Diseases (2024)

To determine if body mass index (BMI) and adipokine levels identify rheumatoid arthritis (RA) patients most likely to benefit from initiation of tumour necrosis factor inhibitors (TNFi) after methotrexate inadequate response.
Shedding light on ultrasound in action: Optical and optoacoustic monitoring of ultrasound brain interventions
Authors: Maria Eleni Karakatsani, Héctor Estrada, Zhenyue Chen, Shy Shoham, Xosé Luís Deán-Ben, Daniel Razansky
Journal: Advanced Drug Delivery Reviews (2024)

Monitoring brain responses to ultrasonic interventions is becoming an important pillar of a growing number of applications employing acoustic waves to actuate and cure the brain. Optical interrogation of living tissues provides a unique means for retrieving functional and molecular information related to brain activity and disease-specific biomarkers. The hybrid optoacoustic imaging methods have further enabled deep-tissue imaging with optical contrast at high spatial and temporal resolution. The marriage between light and sound thus brings together the highly complementary advantages of both modalities toward high precision interrogation, stimulation, and therapy of the brain with strong impact in the fields of ultrasound neuromodulation, gene and drug delivery, or noninvasive treatments of neurological and neurodegenerative disorders. In this review, we elaborate on current advances in optical and optoacoustic monitoring of ultrasound interventions. We describe the main principles and mechanisms underlying each method before diving into the corresponding biomedical applications. We identify areas of improvement as well as promising approaches with clinical translation potential.
Cooperative STAT3-NFkB signaling modulates mitochondrial dysfunction and metabolic profiling in hepatocellular carcinoma
Authors: Sharmeen Ishteyaque, Gurvinder Singh, Karan Singh Yadav, Smriti Verma, Rakesh Kumar Sharma, Sumati Sen, Anurag Kumar Srivastava, Kalyan Mitra, Amit Lahiri, Dnyaneshwar U. Bawankule, Srikanta Kumar Rath, Dinesh Kumar, Madhav Nilakanth Mugale
Journal: Metabolism (2024)
Colorectal cancer screening test exposure patterns in US adults 45 to 49 years of age, 2019-2021
Authors: Jessica Star, Rebecca L Siegel, Adair K Minihan, Robert A Smith, Ahmedin Jemal, Priti Bandi
Journal: JNCI Journal of the National Cancer Institute (2024)

Abstract Several organizations now recommend that individuals at average risk for colorectal cancer (CRC) begin screening at 45 rather than 50 years of age. We present contemporary estimates of CRC screening in newly eligible adults aged 45 to 49 years between 2019 and 2021. Nationally representative prevalence estimates and population number screened were estimated based on the National Health Interview Survey. A logistic regression model assessed CRC screening prevalence differences by survey year and sociodemographic characteristics. In 2021, 19.7%—that is, fewer than 4 million of the eligible 19 million adults aged 45 to 49 years—were up-to-date on CRC screening. Screening was lowest in those who were uninsured (7.6%), had less than a high school diploma (15.4%), and Asian (13.1%). Additionally, fecal occult blood test and/or fecal immunochemical testing was underused, with only 2.4% (&amp;lt;460 000 people) reporting being up-to-date with screening using this modality in 2021. CRC screening in eligible young adults remains low. Concerted efforts to improve screening are warranted, particularly in underserved populations.
The safety and feasibility of same-day discharge for the management of patients undergoing pulmonary lobectomy
Authors: YL Zheng, CC Wang, LD Jin, XY Liang, WS Ye, RS Huang
Journal: Pulmonology (2024)

Is same-day discharge mode safe and feasible for thoracoscopic lobectomy? This study assesses the safety and feasibility of same-day discharge for patients undergoing thoracoscopic lobectomy. We conducted a prospective cohort study from January to December 2022, all patients undergoing thoracoscopic lobectomy were screened for eligibility, and participating eligible patients were separated into a same-day discharge lobectomy (SDDL) group and an inpatient lobectomy (InpL) group based upon length of stay. All discharged patients underwent 30-day postoperative follow-up performed by a team of medical professionals. In addition, eligible patients that underwent thoracoscopic lobectomy from January to December 2021 were included in the historical lobectomy (HisL) group. Of the 52 patients that met the eligibility criteria for same-day discharge, 17 were discharged within 24 h after surgery. In the SDDL group, of whom 1 (5.9%) underwent emergency treatment and readmission within 30 days after surgery due to a pulmonary infection, no patients experienced complications such as reoperation, air leakage, atelectasis, chylothorax, or blood transfusion events during the follow-up period. No differences in overall postoperative complication rates were detected between the SDDL and InpL groups (P>0.05), there was a non-significantly higher rate of readmission and emergency visits in the SDDL group relative to the other two groups (P>0.05). These results emphasize the safety and feasibility of same-day discharge for patients undergoing thoracoscopic lobectomy, it may further revolutionize the general approach to the hospitalization of thoracoscopic lobectomy patients.
EBUS-guided cryobiopsy in the diagnosis of thoracic disorders
Authors: V. Poletti, S. Petrarulo, S. Piciucchi, A. Dubini, A.J. De Grauw, F. Sultani, S. Martinello, H.K. Gonunguntla, C. Ravaglia
Journal: Pulmonology (2024)

Endobronchial Ultrasound (EBUS) has emerged as a crucial tool for diagnosing intrathoracic disorders, particularly in the staging of lung cancer. However, its diagnostic capabilities in the context of benign and rare diseases remain a subject of debate. to investigate the diagnostic yield and safety of EBUS-transbronchial mediastinal cryobiopsy (EBUS-TMC) in comparison to EBUS-transbronchial needle aspiration (TBNA) for a broad spectrum of intrathoracic diseases. a single-centre retrospective observational study conducted on 48 patients who underwent both EBUS-TBNA and endobronchial ultrasound-transbronchial mediastinal cryobiopsy (EBUS-TMC) in the same procedure between August 2021 and October 2023. The overall diagnostic yield of EBUS-TMC surpassed that of EBUS-TBNA (95.8% vs 54.1 %), notably excelling in the diagnosis of sarcoidosis (92.8% vs 78.5 %), rare mediastinal disorders (100% vs 0 %), hyperplastic lymphadenopathy (100% vs 0 %), and lymphoproliferative disease (100% vs 0 %). No significant differences were observed in the diagnosis of NSCLC and SCLC. Samples obtained through EBUS-TMC facilitated the acquisition of NGS and immunohistochemical analyses more readily. EBUS-TMC may contribute to the precise diagnosis and subtyping of mediastinal diseases, especially lymphomas and rare mediastinal tumors, thereby reducing the number of non-diagnostic procedures.
A Visible Light Cross‐Linked Underwater Hydrogel Adhesive with Biodegradation and Hemostatic Ability
Authors: Min Liang, Dandan Wei, Pengfei Ren, Li Xu, Yinghua Tao, Liuxin Yang, Guanhua Jiao, Tianzhu Zhang, Takeshi Serizawa
Journal: Advanced Healthcare Materials (2024)

Abstract Hydrogel adhesives with integrated functionalities are still required to match their ever‐expanding practical applications in the field of tissue repair and regeneration. A simple and effective safety strategy is reported, involving an in situ injectable polymer precursor and visible light‐induced cross‐linking. This strategy enables the preparation of a hydrogel adhesive in a physiological environment, offering wet adhesion to tissue surfaces, molecular flexibility, biodegradability, biocompatibility, efficient hemostatic performance, and the ability to facilitate liver injury repair. The proposed one‐step preparation process of this polymer precursor involves the mixing of gelatin methacryloyl (GelMA), poly(thioctic acid) [P(TA)], poly(acrylic acid)/amorphous calcium phosphate (PAAc/ACP, PA) and FDA‐approved photoinitiator solution, and a subsequent visible light irradiation after in situ injection into target tissues that resulted in a chemically‐physically cross‐linked hybrid hydrogel adhesive. Such a combined strategy shows promise for medical scenarios, such as uncontrollable post‐traumatic bleeding.
Reply to Rui-Cheng Wu, Deng-Xiong Li, and De-Chao Feng’s Letter to the Editor re: Michael Eppler, Conner Ganjavi, Lorenzo Storino Ramacciotti, et al. Awareness and Use of ChatGPT and Large Language Models: A Prospective Cross-sectional Global Survey in Urology. Eur Urol. 2024;85:146–53.
Authors: Michael Eppler, Conner Ganjavi, Andre Abreu, Inderbir Gill, Giovanni E. Cacciamani
Journal: European Urology (2024)
Update and Summary of the European Association of Urology/European Society of Paediatric Urology Paediatric Guidelines on Vesicoureteral Reflux in Children
Authors: Michele Gnech, Lisette 't Hoen, Alexandra Zachou, Guy Bogaert, Marco Castagnetti, Fardod O'Kelly, Josine Quaedackers, Yazan F. Rawashdeh, Mesrur Selcuk Silay, Uchenna Kennedy, Martin Skott, Allon van Uitert, Yuhong Yuan, Christian Radmayr, Berk Burgu
Journal: European Urology (2024)
Corrigendum to “Modelling the potential effectiveness of hepatitis C screening and treatment strategies during pregnancy in Egypt and Ukraine” [J Hepatol (2023) 937–946]
Authors: Nadia Hachicha-Maalej, Intira Jeannie Collins, Anthony E. Ades, Karen Scott, Ali Judd, Aya Mostafa, Elizabeth Chappell, Manal Hamdy-El-Sayed, Diana Gibb, Sarah Pett, Eugènia Mariné-Barjoan, Alla Volokha, Yazdan Yazdanpanah, Sylvie Deuffic-Burban
Journal: Journal of Hepatology (2024)

Modelling the potential effectiveness of hepatitis C screening and treatment strategies during pregnancy in Egypt and UkraineJournal of HepatologyVol. 78Issue 5PreviewHCV test and treat campaigns currently exclude pregnant women. Pregnancy offers a unique opportunity for HCV screening and to potentially initiate direct-acting antiviral treatment. We explored HCV screening and treatment strategies in two lower middle-income countries with high HCV prevalence, Egypt and Ukraine. Full-Text PDF Open Access It has come to our attention that the affiliation of Manal Hamdy-El-Sayed was incorrectly listed as: Department of Community, Environmental, and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt The correct affiliation is: Department of Paediatrics and the Clinical Research Center, Faculty of Medicine, Ain Shams University, Cairo, Egypt. The corrected affiliation list is provided in this corrigendum. We apologise for any inconvenience caused.