tbuckley/cabot-search huggingface dataset:
Cell-type-specific optogenetic fMRI on basal forebrain reveals functional network basis of behavioral preference
Authors: Yijuan Zou, Chuanjun Tong, Wanling Peng, Yue Qiu, Jiangxue Li, Ying Xia, Mengchao Pei, Kaiwei Zhang, Weishuai Li, Min Xu, Zhifeng Liang
Journal: Neuron (2024)

The basal forebrain (BF) is a complex structure that plays key roles in regulating various brain functions. However, it remains unclear how cholinergic and non-cholinergic BF neurons modulate large-scale functional networks and their relevance in intrinsic and extrinsic behaviors. With an optimized awake mouse optogenetic fMRI approach, we revealed that optogenetic stimulation of four BF neuron types evoked distinct cell-type-specific whole-brain BOLD activations, which could be attributed to BF-originated low-dimensional structural networks. Additionally, optogenetic activation of VGLUT2, ChAT, and PV neurons in the BF modulated the preference for locomotion, exploration, and grooming, respectively. Furthermore, we uncovered the functional network basis of the above BF-modulated behavioral preference through a decoding model linking the BF-modulated BOLD activation, low-dimensional structural networks, and behavioral preference. To summarize, we decoded the functional network basis of differential behavioral preferences with cell-type-specific optogenetic fMRI on the BF and provided an avenue for investigating mouse behaviors from a whole-brain view.
Susceptible bacteria can survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance
Authors: Marinelle Rodrigues, Parastoo Sabaeifard, Muhammed Sadik Yildiz, Adam Lyon, Laura Coughlin, Sara Ahmed, Nicole Poulides, Ahmet C. Toprak, Cassie Behrendt, Xiaoyu Wang, Marguerite Monogue, Jiwoong Kim, Shuheng Gan, Xiaowei Zhan, Laura Filkins, Noelle S. Williams, Lora V. Hooper, Andrew Y. Koh, Erdal Toprak
Journal: Cell Host & Microbe (2024)
Clinical Utility of the H2FPEF Score in Patients With Early Atrial Fibrillation
Authors: Reina Hirano, Nobuhiro Ikemura, Dan D. Nguyen, Philip G. Jones, Takehiro Kimura, Yoshinori Katsumata, Ikuko Ueda, Seiji Takatsuki, John A. Spertus, Shun Kohsaka
Journal: JACC Heart Failure (2024)
Recurrent Hospitalizations and Response to Vericiguat in Heart Failure and Reduced Ejection Fraction
Authors: Robert J. Mentz, Amanda Stebbins, Javed Butler, Chern-En Chiang, Justin A. Ezekowitz, Adrian F. Hernandez, Robert Hilkert, Carolyn S.P. Lam, Kenneth McDonald, Christopher M. O’Connor, Burkert Pieske, Piotr Ponikowski, Lothar Roessig, Nancy K. Sweitzer, Adriaan A. Voors, Kevin J. Anstrom, Paul W. Armstrong
Journal: JACC Heart Failure (2024)
Prevalence and Prognostic Impact of Drug Use in Patients Hospitalized for Acute Heart Failure
Authors: Charles Fauvel, Jean-Guillaume Dillinger, Thomas Bochaton, Nicolas Mansencal, Nathalie Noirclerc, Guillaume Schurtz, Thibaut Pommier, Quentin Laissac, Patrick Henry, Théo Pezel
Journal: JACC Heart Failure (2024)
Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy
Authors: Barney Viengkhou, Christine Hong, Curt Mazur, Sagar Damle, Nicholas B Gallo, Terry C Fang, Kate Henry, Iain L Campbell, Fredrik Kamme, Markus J Hofer
Journal: Journal of Clinical Investigation (2024)

Chronic and elevated levels of the antiviral cytokine IFN-α in the brain are neurotoxic. This is best observed in patients with genetic cerebral interferonopathies such as Aicardi-Goutières syndrome. Cerebral interferonopathies typically manifest in early childhood and lead to debilitating disease and premature death. There is no cure for these diseases with existing treatments largely aimed at managing symptoms. Thus, an effective therapeutic strategy is urgently needed. Here, we investigated the effect of antisense oligonucleotides targeting the murine IFN-α receptor (Ifnar1 ASOs) in a transgenic mouse model of cerebral interferonopathy. Intracerebroventricular injection of Ifnar1 ASOs into transgenic mice with brain-targeted chronic IFN-α production resulted in a blunted cerebral interferon signature, reduced neuroinflammation, restoration of blood-brain barrier integrity, absence of tissue destruction, and lessened neuronal damage. Remarkably, Ifnar1 ASO treatment was also effective when given after the onset of neuropathological changes, as it reversed such disease-related features. We conclude that ASOs targeting the IFN-α receptor halt and reverse progression of IFN-α-mediated neuroinflammation and neurotoxicity, opening what we believe to be a new and promising approach for the treatment of patients with cerebral interferonopathies.
Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation
Authors: Xin Liu, Xingyi Wan, Baiyan Sui, Quanhong Hu, Zhirong Liu, Tingting Ding, Jiao Zhao, Yuxiao Chen, Zhong Lin Wang, Linlin Li
Journal: Bioactive Materials (2024)

The impaired differentiation ability of resident cells and disordered immune microenvironment in periodontitis pose a huge challenge for bone regeneration. Herein, we construct a piezoelectric hydrogel to rescue the impaired osteogenic capability and rebuild the regenerative immune microenvironment through bioenergetic activation. Under local mechanical stress, the piezoelectric hydrogel generated piezopotential that initiates osteogenic differentiation of inflammatory periodontal ligament stem cells (PDLSCs) via modulating energy metabolism and promoting adenosine triphosphate (ATP) synthesis. Moreover, it also reshapes an anti-inflammatory and pro-regenerative niche through switching M1 macrophages to the M2 phenotype. The synergy of tilapia gelatin and piezoelectric stimulation enhances in situ regeneration in periodontal inflammatory defects of rats. These findings pave a new pathway for treating periodontitis and other immune-related bone defects through piezoelectric stimulation-enabled energy metabolism modulation and immunomodulation.
Versatile dopamine-functionalized hyaluronic acid-recombinant human collagen hydrogel promoting diabetic wound healing via inflammation control and vascularization tissue regeneration
Authors: Yong Wang, Yuan Zhang, Yun-Peng Yang, Ming-Yuan Jin, Sha Huang, Ze-Ming Zhuang, Tao Zhang, Li-Li Cao, Xiao-Ying Lin, Jun Chen, Yong-Zhong Du, Jian Chen, Wei-Qiang Tan
Journal: Bioactive Materials (2024)

The management of chronic wounds in diabetes remains challenging due to the complexity of impaired wound healing, delayed healing, susceptibility to infection, and elevated risk of reopening, highlighting the need for effective chronic wound management with innovative approaches such as multifunctional hydrogels. Here, we have produced HA-DA@rhCol hydrogels consisting of dopamine-modified hyaluronic acid and recombinant human collagen type-III (rhCol) by oxidative coupling of the catechol group using the H
Engineered 3D liver-tissue model with minispheroids formed by a bioprinting process supported with in situ electrical stimulation
Authors: WonJin Kim, GeunHyung Kim
Journal: Bioactive Materials (2024)

Three-dimensional (3D) bioprinting, an effective technique for building cell-laden structures providing native extracellular matrix environments, presents challenges, including inadequate cellular interactions. To address these issues, cell spheroids offer a promising solution for improving their biological functions. Particularly, minispheroids with 50–100 μm diameters exhibit enhanced cellular maturation. We propose a one-step minispheroid-forming bioprinting process incorporating electrical stimulation (E-MS-printing). By stimulating the cells, minispheroids with controlled diameters were generated by manipulating the bioink viscosity and stimulation intensity. To validate its feasibility, E-MS-printing process was applied to fabricate an engineered liver model designed to mimic the hepatic lobule unit. E-MS-printing was employed to print the hepatocyte region, followed by bioprinting the central vein using a core-shell nozzle. The resulting constructs displayed native liver-mimetic structures containing minispheroids, which facilitated improved hepatic cell maturation, functional attributes, and vessel formation. Our results demonstrate a new potential 3D liver model that can replicate native liver tissues.
Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis
Authors: Clarice X. Lim, Anna Redl, Lisa Kleissl, Ram Vinay Pandey, Carolina Mayerhofer, Thomas El Jammal, Mario Mazic, Karine Gonzales, Nyamdelger Sukhbaatar, Thomas Krausgruber, Christoph Bock, Markus Hengstschläger, Alain Calender, Yves Pacheco, Georg Stary, Thomas Weichhart
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

Chronic sarcoidosis is a complex granulomatous disease with limited treatment options that can progress over time. Understanding the molecular pathways contributing to disease would aid in new therapeutic development.
Single-sample measured glomerular filtration rate in Malawi, South Africa, and Uganda
Authors: Sean Currin, Jaya A. George, Christian Holm Hansen, Saraladevi Naicker, Laurie Tomlinson, Amelia Crampin, Robert Kalyesubula, Robert Newton, Wisdom P. Nakanga, Dorothea Nitsch, June Fabian
Journal: Kidney International (2024)

glomerular filtration rate in Malawi, South Africa, and Uganda.
Percutaneous endoscopic necrosectomy with the assistance of implanted stent to manage walled-off necrosis: first clinical experience
Authors: De-Liang Li, Hongmei Zhang, Jinglong Lv, Libo Quan, Dan Liu, Lixia Zhao, Bingrong Liu
Journal: Endoscopy (2024)

We report the case of a 46-year-old man with walled-off necrosis (WON) due to severe acute pancreatitis and failure of multiple and prolonged percutaneous catheter drainage procedures. As the cavity of WON was far from the gastrointestinal tract, we performed percutaneous endoscopic necrosectomy (PEN) through the sinus ([Video 1]).
Endoscopic ultrasound-guided choledochoduodenostomy using a novel, ultra-stiff, high-sliding guidewire and a dumbbell-shaped metal stent
Authors: Tadahisa Inoue, Mayu Ibusuki, Rena Kitano, Kiyoaki Ito
Journal: Endoscopy (2024)

Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) has potential as a first-line drainage method for malignant distal biliary obstruction. Several randomized controlled trials revealed that EUS-CDS with lumen-apposing metal stent (LAMS) have higher technical success rates and shorter procedure times than conventional transpapillary drainage [1] [2]. However, thin 6-mm diameter LAMSs are frequently used due to their larger flanges, and these stents are associated with adverse events such as biliary wall compression and duodenobiliary reflux, as well as being expensive [3]. Conversely, EUS-CDS using conventional metal stents is associated with a risk of bile leakage due to the need for fistula dilation, as well as stent migration. Herein, we report a new EUS-CDS technique using a novel, ultra-stiff, high-sliding guidewire and a dumbbell-shaped metal stent.
Successful retrieval of a migrated stent in the pancreatic duct after endoscopic ultrasound-guided pancreaticogastrostomy with peroral pancreatoscopy
Authors: Sho Takahashi, Ko Tomishima, Yusuke Takasaki, Akinori Suzuki, Shigeto Ishii, Toshio Fujisawa, Hiroyuki Isayama
Journal: Endoscopy (2024)

Plastic stents are placed at anastomosis sites after endoscopic ultrasound-guided pancreaticogastrostomy (EUS-PGS) [1] [2]. Straight plastic stents have better pushability than double-pigtail plastic stents but are more prone to migrate. We report a case of a straight plastic stent that migrated into the pancreatic duct (PD) and was successfully retrieved. It had been placed during EUS-PGS. The distal end was located at the tail side of the puncture point and was successfully retrieved using the guidewire technique by peroral pancreatoscopy (POPS).
Pancreatic pseudocyst with biliary fistula diagnosed using a novel slim peroral cholangioscope
Authors: Haruo Miwa, Kazuya Sugimori, Kazuki Endo, Ritsuko Oishi, Hiromi Tsuchiya, Takashi Kaneko, Shin Maeda
Journal: Endoscopy (2024)

A novel slim cholangioscope (eyeMax 9-Fr; Micro-Tech, Nanjing, China) has been developed in recent years [1] [2]. We report a case of pancreatic pseudocyst with biliary fistula diagnosed using this novel cholangioscope ([Video 1]).
Funnel-hood-assisted endoscopic retrograde appendicitis therapy for acute appendicitis
Authors: Qingtian Luo, Shaoxiong Zeng, Minwen Jiang, Qu Zhang, Chunsheng Cheng
Journal: Endoscopy (2024)

Acute appendicitis is one of the most common acute abdominal conditions in the clinic, and is characterized by an acute onset, severe symptoms, and rapid progression [1]. Currently, endoscopic retrograde appendicitis therapy (ERAT) is an emerging treatment method for acute appendicitis, which involves colonoscopically guided intubation of the appendix, drainage of pus, imaging to clarify the diagnosis, flushing of the lumen, placement of drainage, and so on, to relieve the obstruction and reduce the pressure in the appendiceal lumen [2]. ERAT has the advantages of less trauma, shorter operation time, shorter hospital stay, lower complication rate, faster postoperative recovery, preservation of appendiceal immunity, and absence of surgical scar [2] [3]. However, the conventional transparent hood and guidewire used for ERAT, the contrast catheter, and other instruments do not enter the appendiceal lumen easily, often leading to failure of the operation, and this limits the popularity and widespread adoption of ERAT [4].
Evolution of respiratory syncytial virus burden in young children following the COVID-19 pandemic: influence of concomitant changes in testing practices – Author's reply
Authors: You Li
Journal: The Lancet Infectious Diseases (2024)

I thank Inès Fafi and colleagues for their Correspondence on our study of the changes in the burden of respiratory syncytial virus (RSV) hospitalisations in young children during the COVID-19 pandemic.1 Fafi and colleagues rightly emphasised the need to consider variations in RSV-testing practices when estimating the disease burden during the COVID-19 period. Although we appreciate their insightful observations, we would like to address certain aspects of our methodology and findings that seemed to have been misinterpreted in their Correspondence.
What is the specific role of schools and daycares in COVID-19 transmission? A final report from a living rapid review
Authors: Sarah E Neil-Sztramko, Emily Belita, Robyn L Traynor, Leah Hagerman, Selin Akaraci, Patricia Burnett, Alyssa Kostopoulos, Maureen Dobbins
Journal: The Lancet Child & Adolescent Health (2024)
Genomics of human NAFLD: Lack of data reproducibility and high interpatient variability in drug target expression as major causes of drug failures
Authors: Shifang Tang, Jürgen Borlak
Journal: Hepatology (2024)

NAFLD is a major disease burden and a foremost cause of chronic liver disease. Presently, nearly 300 trials evaluate the therapeutic efficacy of > 20 drugs. Remarkably, the majority of drugs fail. To better comprehend drug failures, we investigated the reproducibility of fatty liver genomic data across 418 liver biopsies and evaluated the interpatient variability of 18 drug targets.
Repositioning of ezetimibe for the treatment of idiopathic pulmonary fibrosis
Authors: Chanho Lee, Se Hyun Kwak, Jisu Han, Ju Hye Shin, Byunghun Yoo, Yu Seol Lee, Jeong Su Park, Beom Jin Lim, Jin Gu Lee, Young Sam Kim, Song Yee Kim, Soo Han Bae
Journal: European Respiratory Journal (2024)

Background We previously identified ezetimibe, an inhibitor of Niemann–Pick C1-like intracellular cholesterol transporter 1 and European Medicines Agency-approved lipid-lowering agent, as a potent autophagy activator. However, its efficacy against pulmonary fibrosis has not yet been evaluated. This study aimed to determine whether ezetimibe has therapeutic potential against idiopathic pulmonary fibrosis. Methods Primary lung fibroblasts isolated from both humans and mice were employed for mechanistic in vitro experiments. mRNA sequencing of human lung fibroblasts and gene set enrichment analysis were performed to explore the therapeutic mechanism of ezetimibe. A bleomycin-induced pulmonary fibrosis mouse model was used to examine in vivo efficacy of the drug. Tandem fluorescent-tagged microtubule-associated protein 1 light chain 3 transgenic mice were used to measure autophagic flux. Finally, the medical records of patients with idiopathic pulmonary fibrosis from three different hospitals were reviewed retrospectively, and analyses on survival and lung function were conducted to determine the benefits of ezetimibe. Results Ezetimibe inhibited myofibroblast differentiation by restoring the mechanistic target of rapamycin complex 1–autophagy axis with fine control of intracellular cholesterol distribution. Serum response factor, a potential autophagic substrate, was identified as a primary downstream effector in this process. Similarly, ezetimibe ameliorated bleomycin-induced pulmonary fibrosis in mice by inhibiting mechanistic target of rapamycin complex 1 activity and increasing autophagic flux, as observed in mouse lung samples. Patients with idiopathic pulmonary fibrosis who regularly used ezetimibe showed decreased rates of all-cause mortality and lung function decline. Conclusion Our study presents ezetimibe as a potential novel therapeutic for idiopathic pulmonary fibrosis.
Notice of Retraction and Replacement. McAlearney et al. Effect of In-Person vs Video Training and Access to All Functions vs a Limited Subset of Functions on Portal Use Among Inpatients: A Randomized Clinical Trial. <i>JAMA Netw Open.</i> 2022;5(9):e2231321
Authors: Ann Scheck McAlearney, Daniel M. Walker
Journal: JAMA Network Open (2024)
Early Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease: The Costs and Benefits of Case Finding
Authors: Shawn D. Aaron, Maria Montes de Oca, Bartolome Celli, Surya P. Bhatt, Jean Bourbeau, Gerard J. Criner, Dawn L. DeMeo, David M. G. Halpin, MeiLan K. Han, John R. Hurst, Jamuna K. Krishnan, David Mannino, Job F. M. van Boven, Claus F. Vogelmeier, Jadwiga A. Wedzicha, Barbara P. Yawn, Fernando J. Martinez
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Early Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease: The Costs and Benefits of Case Finding." American Journal of Respiratory and Critical Care Medicine, 209(8), pp. 928–937
Correction:<i>Identification of two tofacitinib subpopulations with different relative risk versus TNF inhibitors: an analysis of the open label, randomised controlled study ORAL Surveillance</i>
Journal: Annals of the Rheumatic Diseases (2024)

In figure 1C of the originally published version of the manuscript, the plotted value for All cause death for the Age ≥65 years and Ever smoked group showed the incidence rate (95% Confidence Interval [CI]) (1.81 (1.15, 2.71)) instead of the hazard ratio (HR) vs tumour necrosis factor inhibitors (TNFi (95% CI)) (2.09 (0.85, 5.13)).This data point has now been corrected to show the HR vs TNFi (95% CI).The corrected figure panel is included below.
Neurological, psychiatric, and sleep investigations after treatment of anti-leucine-rich glioma-inactivated protein 1 (LGI1) encephalitis in Spain: a prospective cohort study
Authors: Amaia Muñoz-Lopetegi, Mar Guasp, Laia Prades, Eugenia Martínez-Hernández, Mireia Rosa-Justícia, Víctor Patricio, Thaís Armangué, Lorena Rami, Roger Borràs, Josefina Castro-Fornieles, Albert Compte, Carles Gaig, Joan Santamaria, Josep Dalmau
Journal: The Lancet Neurology (2024)
Reticulated livedoid skin patterns after soft-tissue filler–related vascular adverse events
Authors: Leonie W. Schelke, Peter J. Velthuis, Ali Mojallal, Guillaume Henry, Stefan O.P. Hofer, Sebastian C. Cotofana
Journal: Journal of the American Academy of Dermatology (2024)

For the treatment of vascular adverse events caused by filler injections, duplex ultrasound imaging may be used. The findings of duplex ultrasound examination and the clinical features of reticulated livedoid skin patterns were compared with the hemifaces anatomy.
Monitoring patients with severe traumatic brain injury – Authors' reply
Authors: Jean-Francois Payen, Tobias Gauss, Antoine Vilotitch, Pierre Bouzat
Journal: The Lancet Neurology (2024)

We fully agree with Randall M Chestnut and colleagues' comments and thank them for underlining important considerations. The findings from OXY-TC trial1 do raise questions on the heterogeneity of patients with severe traumatic brain injury despite comparable Glasgow Coma Scale scores at baseline. Pooled data from the trials OXY-TC, BOOST3, and BONANZA might provide sufficiently robust evidence to identify the patients who most likely benefit from multimodal invasive brain monitoring.
Adenine Nucleotide Translocators Control Kidney Metabolism and Lipid Handling
Authors: Sho Sugahara, Craig R. Brooks
Journal: Journal of the American Society of Nephrology (2024)

1Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 2Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee Correspondence: Dr. Craig R. Brooks, Division of Nephrology, Vanderbilt University Medical Center, 1161 21st Avenue South, MCN, Nashville, TN 37232. Email: [email protected] Published Online Ahead of Print. Publication date available at www.jasn.org See related article, "Renal Mitochondrial ATP Transporter Ablation Ameliorates Obesity-Induced CKD," on pages 281–298.
Endoscopic ultrasound-guided partial splenic embolization for hypersplenism: a novel alternative
Authors: Ping Liu, Shan-shan Zhu, Xin-Guang Cao, Pradermchai Kongkam, Saif Ullah, Chang-Qing Guo
Journal: Endoscopy (2024)

Variceal bleeding and hypersplenism are two major complications of portal hypertension, for which the management includes partial splenic embolization (PSE) [1]. A recent multicenter clinical trial confirmed that the combination of endoscopy and radiography-guided partial splenic embolization (X-PSE) provided advantages over conventional endoscopic treatment alone for the prevention of variceal rebleeding in patients with liver cirrhosis [2]. X-PSE requires arterial puncture via the femoral artery and relies on radiographic imaging to guide the catheter, with risks including post-embolization syndrome. In addition, the method is not suitable for patients who are unwilling or unsuitable to undergo radiation, such as pregnant patients or patients planning to conceive.
Retroflexed endoscopic submucosal dissection of a lesion invading the pyloric ring, using a newly developed thin endoscope
Authors: Satoki Shichijo, Daiki Kitagawa, Yuya Asada, Shunsuke Yoshii, Noriya Uedo, Ryu Ishihara, Tomoki Michida
Journal: Endoscopy (2024)

Endoscopic resection of a pyloric lesion is challenging because of the limited maneuverability of endoscopes. Here, we report a case of a depressed pyloric lesion treated with endoscopic resection using a newly developed thin endoscope.
Endoscopic submucosal dissection for esophageal cancer behind a tracheoesophageal voice prosthesis
Authors: Yasuhiro Tani, Koji Higashino, Takashi Kanesaka, Kengo Aoki, Takashi Fujii, Tomoki Michida, Ryu Ishihara
Journal: Endoscopy (2024)

A tracheoesophageal voice prosthesis is used to restore vocal communication after a total laryngectomy [1] [2]. This device may interfere with the endoscope during endoscopic treatment of an esophageal lesion. However, its removal poses a risk of aspiration because it is located in a tracheoesophageal fistula. We successfully performed endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell carcinoma behind a tracheoesophageal voice prosthesis.