tbuckley/cabot-search huggingface dataset:
REPORT OF A CASE OF LEFT VENTRICULAR FAILURE WITH UNUSUAL ANATOMICAL CHANGES IN THE MYOCARDIUM
Authors: H. Roesler, Louis A. Soloff
Journal: Annals of Internal Medicine (1935)

Case Reports1 October 1935REPORT OF A CASE OF LEFT VENTRICULAR FAILURE WITH UNUSUAL ANATOMICAL CHANGES IN THE MYOCARDIUMH. ROESLER, M.D., LOUIS A. SOLOFF, M.D.H. ROESLER, M.D.Search for more papers by this author, LOUIS A. SOLOFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-4-477 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe recent publications of Weiss1 and of White2 have added much to the existing knowledge of the symptomatology of left ventricular failure. Our case is definitely an example of this condition and is the source of added information regarding the pathologic alterations and roentgenoscopic diagnosis.A 37 year old white man, a clerk by occupation, was admitted to the hospital on February 11, 1933. He had had scarlet fever in childhood, and influenza in 1918. There was no history of rheumatism or syphilis, and a physical examination five years ago was said to be negative. One and one-half years ago...References1. WEISS S: Cardiac asthma (paroxysmal cardiac dyspnea) and syndrome of left ventricular failure, Jr. Am. Med. Assoc., 1933, c, 1841-1846. CrossrefGoogle Scholar2. WHITE PD: Weakness and failure of left ventricle without failure of right ventricle; clinical recognition, Jr. Am. Med. Assoc., 1933, c, 1993-1998. CrossrefGoogle Scholar3. ZDANSKY E: Über das Röntgenbild des Lungenödems, gleichzeitig ein Beitrag zur Frage der Pathogenese des Lungenödems, Röntgenpraxis, 1933, v, 248-253. Google Scholar4. CHAPMAN JF: Passive congestion of lungs in presence of coronary sclerosis, Radiology, 1931, xvii, 342-345. CrossrefGoogle Scholar5. KORNS HM: Notes on heart failure, with report of case of pure left ventricular failure, Am. Heart Jr., 1932, viii, 242-248. CrossrefGoogle Scholar6. COEOTELL FOLS: Acute pulmonary edema, Am. Jr. Roentgenol., 1932, xxvii, 101-102. Google Scholar7. ROUBIERPLAUCHU CM: Sur certains aspects radiographiques de l'oedème pulmonaire chez les cardiorénaux, Lyon méd., 1933, clii, 137-145. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication June 12, 1934.From the Departments of Medicine, Roentgenology and Pathology, Temple University Hospital, Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1935Volume 9, Issue 4Page: 477-487KeywordsAnatomical pathologyHospital medicineMyocardiumScarlet feverSyphilis Issue Published: 1 October 1935 PDF downloadLoading ...
Abstract 1762: An Emerging Option for Women with Advanced Heart Failure: Results of the HeartMate II Continuous Flow Left Ventricular Assist Device Bridge to Transplant Trial
Authors: Roberta C Bogaev, Leway Chen, Stuart D Russell, Joseph G Rogers, David J Farrar, Stephanie A Moore
Journal: Circulation (2007)

Introduction: Women with advanced heart failure (HF) are under-represented in left ventricular assist device (LVAD) trials. Only 9–16% of patients (pts) studied in investigations of the first gener...
Abstract 173: Early Combined Cooling Improves the Cerebral and Cardiac Microcirculation in a Prolonged Cardiac Arrest and Cardiopulmonary Resuscitation Porcine Model
Authors: Tao Yu, Heng Li, Zhengfei Yang, Yongqin Li, Bihua Chen, Longyuan Jiang, Youde Ding, Zitong Huang
Journal: Circulation (2013)
Abstract 898: Can Angiography With Synchrotron Radiation And A High Sensitivity Receiver Make Lower Doses Of Contrast Medium Possible?
Authors: Taisuke Konishi, Shonosuke Matsushita, Kazuyuki Hyodo, Haruhiko Sugimori, Chiho Tokunaga, Yoshiharu Enomoto, Shinya Kanemoto, Yutaka Watanabe, Yuji Hiramatsu, Yuzuru Sakakibara
Journal: Circulation (2008)

Introduction: Contrast-induced nephropathy (CIN) is a serious complication associated with angiography and interventional angioplasty. Increased doses of contrast medium are a major risk factor of CIN. It was assumed that the occurrence of CIN could be decreased by reducing the dose of contrast medium. We investigated the effects of a new high resolution and high contrast angiographic system on the application of diluted contrast medium. Method: Contrast medium was diluted to 32% (a stock solution), 24%, 16%, 12%, 8%, and 4%. Angiography of the hindlimb in rats using a synchrotron radiation and HARP receiver were performed with each concentration of contrast medium (n=5, respectively). The characteristics of synchrotron radiation are high photon density (10,000 times that of conventional X-rays) and straightness of the beam, which lead to high resolution (26 micrometer/pixel). A HARP Receiver is a high sensitivity image capturing system, which was developed by NHK Sci &amp; Tech Res Lab (Tokyo, Japan). It is about 100 times more sensitive than conventional CCD cameras. Each angiographic image was evaluated by 256 grayscale intensity using graphic software NIH Image. The availability of each image as angiography was determined by the judgment of 5 independent cardiologists respectively. Results: In 256 grayscale, the minimum visible contrast distance for identifying vessels was 10. The value of each image in different concentrations of contrast medium was as follows: 4%: 14+/−12, 8%: 22+/−10, 12%: 23+/−18, 16%: 25+/−11, 24%: 28+/−11, 32%: 40+/−10. Vessels are identified from 4% to 32%. Availability as angiography was confirmed from 8% to 32% by common assent. Conclusions: The angiographic system using synchrotron radiation and a HARP receiver was able to take angiographic images with as low as 8% contrast medium. This may lead to beneficial effects in patients who cannot undergo sufficient angiography and interventional angioplasty due to renal dysfunction.
MPs table bill to restrict role of commercial companies in NHS
Authors: G. Iacobucci
Journal: BMJ (2015)

The NHS Bill 2015, which proposes abolishing competition and restricting the role of commercial companies in the NHS in England, is to be retabled before parliament on Wednesday 1 July.

It will be tabled as a private member’s bill by the Green Party MP Caroline Lucas and is expected to have cross party support from around a dozen sponsors in total.

The bill is based on the NHS Reinstatement Bill that was coauthored in 2014 by Allyson Pollock, professor of public health research and policy at Queen Mary University of London, and Peter Roderick, barrister and senior research fellow at the university’s Centre for Primary Care and Public Health.1

It was first co-tabled as the NHS Bill in March 2015 by Lucas and the …
Genitourinary medicine services are important
Authors: R. Hillman, A. Scoular, S. McMillan
Journal: BMJ (1995)

EDITOR,—Two articles report the alarming spread of HIV in a Scottish prison.1 2 While intravenous drug use in prisons is clearly a major risk factor in the spread of HIV among inmates, we believe that the role of sexual intercourse also needs to be more thoroughly examined.

Sexual intercourse occurs between incarcerated men,2 …
The effect of marijuana on carbohydrate metabolism
Authors: M A Permutt, D W Goodwin, R Schwin, S Y Hill
Journal: American Journal of Psychiatry (1976)

The authors observed the effect of marijuana on carbohydrate metabolism in fed and fasting states in chronic marijuana users. They found no hypoglycemia in 7 patients who were given marijuana after fasting for 24-72 hours. They also found no significant difference in carbohydrate tolerance and no hypoglycemia during an oral glucose tolerance test in 10 patients who smoked placebo or marijuana on alternate days. They conclude that marijuana has no effect on carbohydrate metabolism in the fed or the fasted state in well-nourished chronic marijuana users.
Outcome in stage IV Wilms tumor treated according to the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) trials
Authors: L. Gandola, M. Nantron, A. Marchianò, A. Pession, P. Indolfi, A. Di Cataldo, P. Collini, G. Arcamone, F. Fossati Bellani, F. Spreafico
Journal: Journal of Clinical Oncology (2009)

10031 Background: Children with metastases at diagnosis for Wilms tumor (WT) still display a worse prognosis compared to localized disease. Methods: We analyzed survival results in patients with stage IV WT enrolled in the AIEOP CNR92 and TW2003 clinical trials (3/1992–3/2008). Treatment strategy across these trials evolved in terms of sparing whole lung radiotherapy (RT) in case of complete disappearance of lung metastases after primary chemotherapy and a doxorubicin cumulative dose reduction from 360 mg/m 2 to 240 mg/m 2 in TW2003. Results: Of 553 in-study patients aged less than 18 years, 68 (12%) were classified as stage IV (38 patients in CNR92, 30 in TW2003; median age 58 months). Children displaying millimetric nodules visible only on computed tomography scan were excluded. Initial treatment consisted of 6-week 3-drug (vincristine, dactinomycin, doxorubicin) phase in 60 cases, while 8 had up-front nephrectomy. Adjuvant therapy included 8-month 3-drug chemotherapy for non anaplastic “local” tumor stage I to III (flank RT for stage III), or an intensified regimen for anaplastic histology, adding etoposide, carboplatinum and ifosfamide (6 patients). Overall 19 tumor failure occurred (3 in anaplastic tumors): metastases progression 9, abdominal relapse 5 (combined to liver and mediastinum in 1 case each), lung 4, liver 1. After a median follow-up of 53 months 5-yr RFS and OS were 71% ±6 and 77% ±5 for the whole cohort of children, respectively. Overall, RFS was 86% in patients who achieved a complete metastases remission (in 2 cases by surgery) compared to 55% in patients who did not (Logrank p&lt;.05). Noteworthy the omission of lung RT in TW2003 trial for complete responders evaluated at week 6 did not jeopardize survival (85% RFS, vs 58% for those children with persistence of metastases and lung RT). There was a trend toward a worse outcome for patients with at least liver metastases (n 13) compared to those with other site (4-yr RFS 49% vs 74%, p=.1). Conclusions: Failure to obtain metastases complete remission, and maybe site other than lung, should be considered for chemotherapy intensification for metastatic WT. The impact of metastatic tumor burden deserves further analysis. Withholding RT in rapidly complete responders patients did not compromise outcome. No significant financial relationships to disclose.
Abstract 13817: Methamphetamine Use is Common Among Patients with Pulmonary Arterial Hypertension (PAH) in California and is Associated with Worse Long-Term Survival Compared with Idiopathic PAH
Authors: Christopher F Barnett, Brandon M Wiley, Lynn Oveson, Nimaljeet Tarango, Erin Kobashigawa, Teresa De Marco, Dana McGlothlin
Journal: Circulation (2012)

Methamphetamine (meth) abuse is a major public health problem in the United States. Meth use has been linked to PAH in up to 30% of cases of idiopathic PAH (IPAH), however there are few studies tha...
Abstract 911: Usefulness of Coronary Fractional Flow Reserve Measurements to Guide Clinical Decisions in Intermediate Left Main Coronary Stenoses. Results of a Study Including 142 Consecutive Patients
Authors: Josep Rodès-Cabau, Javier Courtis, Jean-Michel Potvin, Melanie Côté, Jean-Pierre Dery, Eric Larose, Can M Nguyen, Onil Gleeton, Louis Roy, Robert DeLarochellière, Olivier F Bertrand
Journal: Circulation (2008)

Background: Limited data exist on the use of fractional flow reserve (FFR) measurements to guide clinical decisions in patients with intermediate left main coronary artery (LMCA) stenosis. Objectives: To evaluate the usefulness of FFR measurements to guide the clinical decision in patients with intermediate LMCA stenosis and to determine the predictors of major adverse cardiac events [MACE] (cardiac death, myocardial infarction, coronary revascularization) in such cases. Methods: A total of 142 consecutive patients (mean age 62 ± 10 yrs) with intermediate LMCA stenosis (mean percent diameter stenosis 42 ± 13%) were included. All patients underwent FFR measurement after intracoronary (ic) administration of adenosine at a dose ≥30 μg. Special care was taken in cases with ostial lesions to pull the catheter out of the LMCA after adenosine administration. The clinical decisions were based on FFR as follows: coronary revascularization was recommended if FFR was &lt;0.75, medical treatment if FFR was &gt;0.80, and individualized decision based on additional clinical data if FFR was between 0.75 and 0.80. The occurrence of MACE was evaluated at 14 ± 11 months follow-up. Results: Mean FFR was 0.81 ± 0.09 after the administration of a mean dose of 176 ± 99 μg of ic adenosine. Based on FFR results, sixty patients (42%) underwent coronary revascularization and 82 patients (58%) received medical treatment. At follow-up, the incidence of MACE related to the LMCA stenosis was 13% in the medical treatment group and 7% in the coronary revascularization group (p=0.27). The incidence of cardiac death and myocardial infarction was 7% in both groups (p=1.0). In the medical treatment group, patients with MACE had received a lower dose of ic adenosine (86 ± 57 μg vs. 167 ± 102 μg, OR: 1.39 for each decrease of 30 μg of ic adenosine, 95% CI 1.02–1.89, p=0.04) and were more frequently diabetics (55% vs. 21%, OR: 4.40, 95% CI 1.17–16.42, p=0.02). Conclusions: FFR measurement is helpful in guiding the decision as to whether to revascularize patients with intermediate LMCA stenosis. However, diabetic patients remain at higher risk, and higher doses than previously recommended of ic adenosine should be used in the evaluation of LMCA to avoid cardiac events due to underestimation of stenosis severity.
Cholangiolocellular carcinoma with satellite nodules showing intermediate differentiation
Authors: Wonkyung Jung, Baek-hui Kim
Journal: Clinical and Molecular Hepatology (2015)

Cholangiolocellular carcinoma, a rare type of primary malignant tumor of liver, is thought to originate from cholangioles or canals of Hering, where hepatic progenitor or stem cells are located,1,2 and has characteristic histologic features of tubular, cord-like and 'antler-like' pattern with marked fibrous stroma.3 Cholangiolocellular carcinoma was previously classified as one type of intrahepatic cholangiocarcinoma. But now, on the basis of the concept that combined hepatocellular-cholangiocarcinoma is derived from hepatic progenitor cells, cholangiolocellular carcinoma is classified as combined hepatocellular-cholangiocarcinoma with stem-cell features in the latest version of the World Health Organization (WHO) classification of the digestive system 2010.3 Because of its limited number of cases, its biologic behavior or clinical outcomes have not been fully understood.
Abstract 3803: Influence of Autopsy Records on Classification of Sudden Unexpected Death in Patients With Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure or Both
Authors: Anne-Catherine M Pouleur, Ebrahim Barkoudah, Hajime Uno, Hicham Skali, Peter Finn, Steven Zelenkofske, John J McMurray, Sergei Varshavsky, Yuri N Belenkov, Viatcheslav Mareev, Eric J Velazquez, Jean L Rouleau, Aldo P Maggioni, Lars Kober, Robert M Califf, Marc A Pfeffer, Scott D Solomon
Journal: Circulation (2009)
Are generalists still needed in a specialised world?
Authors: C. Reid
Journal: BMJ (2000)

Editor—Turnberg in his article on the survival of the general physician rightly highlights the potential problems posed when an undifferentiated emergency patient is cared for by medical subspecialists.1 Four models of care are proposed as possible solutions, including the development of specialised emergency physicians, calling for a new breed of doctor and a specific training programme, although its success would depend on having enough doctors who are sufficiently motivated to take on this type of work.

The specialty of emergency medicine already exists, but its potential for contributing to a solution to the problem remains unfulfilled because of historical, cultural, and resource factors as well as perhaps the stubborn retention of the UK-specific name “accident and emergency medicine.”

Turnberg alludes to the difficulties medical subspecialists have in maintaining their general skills and knowledge. Accident and emergency physicians now undergo a five year specialist training programme whose exit examination requires the demonstration of knowledge and skills in all aspects of clinical emergency medicine as well as evidence based critical appraisal and management skills. No such objective final assessment exists for trainees in general (internal) medicine. An expansion in the numbers of accident and emergency consultants, combined with a sociopolitical climate in which senior doctors' participation in all aspects of patient care will be demanded, suggests that the time is right to expand the role of accident and emergency doctors.

I therefore propose a fifth model: the undifferentiated emergency patient is cared for on an admissions or observation unit integral to the hospital's emergency department, under the supervision of the accident and emergency consultant on duty. Medical subspecialists provide advice and ongoing care when indicated. Patients no longer acutely ill who require further investigation and diagnostic expertise are referred to the general (internal) medicine specialists. This way acutely ill patients remain under the care of physicians motivated and trained to provide that care. The current system of separate medical assessment units and emergency departments, with its consequent duplication of precious resources, would end, and a single point of hospital entry would exist for emergency patients regardless of whether they dialled 999 or were referred by their general practitioner.

To create a new emergency specialty would perpetuate this duplication and thinning of resources for the patients who most need them. Far better to invest in those specialties we already have, since Turnberg's “new breed” is already breeding.
Targeted resequencing analysis of 31 genes commonly mutated in myeloid disorders in serial samples from myelodysplastic syndrome patients showing disease progression
Authors: A Pellagatti, S Roy, C Di Genua, A Burns, K McGraw, S Valletta, M J Larrayoz, M Fernandez-Mercado, J Mason, S Killick, C Mecucci, M J Calasanz, A List, A Schuh, J Boultwood
Journal: Leukemia (2015)

Targeted resequencing analysis of 31 genes commonly mutated in myeloid disorders in serial samples from myelodysplastic syndrome patients showing disease progression
Abstract 16840: Sudden Death Caused by Ruptured Abdominal Aortic Aneurysm is Highly Related to Left Main Trunk Coronary Stenosis
Authors: Atsuko Nakayama, Hiroyuki Morita, Akihiko Hamamatsu, Masatoshi Nagayama, Tetsuya Sumiyoshi, Issei Komuro
Journal: Circulation (2013)

Background: The sudden death caused by ruptured abdominal aortic aneurysm (RAAA) remains a pending problem. The relevance of coronary artery lesions to sudden death in RAAA patients is also unknown...
Statistics Notes: Measurement error and correlation coefficients
Authors: J M. Bland, D. G Altman
Journal: BMJ (1996)

Measurement error is the variation between measurements of the same quantity on the same individual.1 To quantify measurement error we need repeated measurements on several subjects. We have discussed the within-subject standard deviation as an index of measurement error,1 which we like as it has a simple clinical interpretation. Here we consider the use of correlation coefficients to quantify measurement error.

A common design for the investigation of measurement error is to take pairs of measurements on a group of subjects, as in table 1. When we have pairs of observations it is natural to plot one measurement against the other. The resulting scatter diagram (see figure 1 may tempt us to calculate a correlation coefficient between the first and second measurement. There are difficulties in interpreting this correlation coefficient. In general, the correlation between repeated measurements will depend on the variability between subjects. Samples containing subjects who differ greatly will produce larger correlation coefficients than will samples containing similar …
Ecologic Regression Analysis and the Study of the Influence of Air Quality on Mortality
Authors: S. Selvin, D. Merrill, L. Wong, S. T. Sacks
Journal: Environmental Health Perspectives (1984)

This presentation focuses entirely on the use and evaluation of regression analysis applied to ecologic data as a method to study the effects of ambient air pollution on mortality rates. Using extensive national data on mortality, air quality and socio-economic status regression analyses are used to study the influence of air quality on mortality. The analytic methods and data are selected in such a way that direct comparisons can be made with other ecologic regression studies of mortality and air quality. Analyses are performed by use of two types of geographic areas, age-specific mortality of both males and females and three pollutants (total suspended particulates, sulfur dioxide and nitrogen dioxide). The overall results indicate no persuasive evidence exists of a link between air quality and general mortality levels. Additionally, a lack of consistency between the present results and previous published work is noted. Overall, it is concluded that linear regression analysis applied to nationally collected ecologic data cannot be used to usefully infer a causal relationship between air quality and mortality which is in direct contradiction to other major published studies.
Non-government organisations should be catalysts for change
Authors: J Mann
Journal: BMJ (1995)

EDITOR,—Fiona Godlee's articles on the World Health Organisation fairly describe an institution in disarray.1 WHO has become outdated and sclerosed and desperately needs to be revitalised if it is to provide health leadership for the modern world. In fact, except in its inner sanctum and in some ministries of health, there is widespread agreement about the need for major reform. Yet unless some action is taken soon the current leadership will continue and urgently needed institutional overhaul will be postponed.

Who should be responsible for catalysing and carrying forward the reform? In the past, middle level health officials from many countries …
O065 : Mechanistic study of TM6SF2 in NAFLD pathogenesis: Stably transfected Huh7 cells over-expressing the TM6SF2 E167K variant exhibit greater levels of oxidative stress
Authors: J. Palmer, Y.-L. Liu, C.P. Day, A. Daly, Q.M. Anstee
Journal: Journal of Hepatology (2015)