tbuckley/cabot-search huggingface dataset:
Considerations regarding a prediction model of surgical site infection after gastrointestinal surgery
Authors: Shenglin Zhao, Hong Zhou, Mei He
Journal: International Journal of Surgery (2024)

aOffice of Chongqing Cancer Prevention and Treatment, Chongqing University Cancer Hospital, Chongqing 400030, People's Republic of China bChongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, People's Republic of China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Office of Chongqing Cancer Prevention and Treatment, Chongqing University Cancer Hospital, Chongqing 400030, People's Republic of China. Tel.: +86 19122969595. E-mail address: [email protected] (M. He). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A commentary on “Distribution of coronal plane alignment of the knee classification in Chinese osteoarthritic and healthy population: A retrospective cross-sectional observational study”
Authors: Ao Xiong, Fei Luo, Hong Lu
Journal: International Journal of Surgery (2024)

aDepartment of Radiology, Central Hospital Affiliated to Chongqing University of Technology, 400054, Chongqing, China bDepartment of Orthopaedics, First Affiliated Hospital, Army Medical University (Third Military Medical University), 400038,Chongqing, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Radiology, Central Hospital Affiliated to Chongqing University of Technology, 400054, Chongqing, China. E-mail address: [email protected] (H. Lu). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Comparing the oncologic outcomes of local tumor destruction vs. local tumor excision vs. partial nephrectomy in T1a solid renal masses: a population-based cohort study from the SEER database
Authors: Run-Qi Guo, Jin-Zhao Peng, Jie Sun, Yuan-Ming Li
Journal: International Journal of Surgery (2024)

There are few large-scale analyses comparing local tumor destruction (LTD) or local tumor enucleation/excision (LTE) relative to partial nephrectomy (PN) for patients with T1a renal masses in terms of cancer-specific survival (CSS) and overall survival (OS). The authors aimed to compare CSS and OS after LTD versus LTE versus PN.
The safety, feasibility and oncological outcomes of laparoscopic completion total gastrectomy for remnant gastric cancer: a prospective study with 3-year follow-up (FUGES-004 study)
Authors: Qing Zhong, Dong Wu, Yiming Jiang, Qing-Liang He, Xue-Yi Dang, Dong-Bo Xu, Yuqin Sun, Guo-Qiang Su, Kai-Qing Guo, Li-Sheng Cai, Haoxiang Zhang, Wen Ye, Guangtan Lin, Ping Li, Jian-Wei Xie, Qi-Yue Chen, Chao-Hui Zheng, Jun Lu, Chang-Ming Huang, Jian-Xian Lin
Journal: International Journal of Surgery (2024)

Background: The efficacy of laparoscopic completion total gastrectomy (LCTG) for remnant gastric cancer (RGC) remains controversial. Methods: The primary outcome was postoperative morbidity within 30 days after surgery. Secondary outcomes included 3-year disease-free survival (DFS), 3-year overall survival (OS), and recurrence. Inverse probability treatment weighted (IPTW) was used to balance the baseline between LCTG and OCTG. Results: Final analysis included 46 patients with RGC who underwent LCTG at the FJMUUH between June 2016 and June 2020. The historical control group comprised of 160 patients who underwent open completion total gastrectomy (OCTG) in the six tertiary teaching hospitals from CRGC-01 study. After IPTW, no significant difference was observed between the LCTG and OCTG groups in terms of incidence (LCTG vs. OCTG: 28.0% vs. 35.0%, P =0.379) or severity of complications within 30 days after surgery. Compared with OCTG, LCTG resulted in better short-term outcomes and faster postoperative recovery. However, the textbook outcome rate was comparable between the two groups (45.9% vs. 32.8%, P =0.107). Additionally, the 3-year DFS and 3-year OS of LCTG were comparable to those of OCTG (DFS: log-rank P =0.173; OS: log-rank P =0.319). No significant differences in recurrence type, mean recurrence time, or 3-year cumulative hazard of recurrence were observed between the two groups (all P &gt;0.05). Subgroup analyses and concurrent comparisons demonstrated similar trends. Conclusions: This prospective study suggested that LCTG was non-inferior to OCTG in both short- and long-term outcomes. In experienced centers, LCTG may be considered as a viable treatment option for RGC.
Advances in management of heart failure
Authors: Paul Heidenreich, Alexander Sandhu
Journal: BMJ (2024)

ABSTRACT Heart failure is increasing in prevalence in many countries with aging populations. Fortunately, remarkable scientific advances have been made in the past few years that have led to new treatments and improved prognosis for patients with heart failure. This review examines these changes with a focus on the diagnosis and medical management of heart failure. The changes include the increase to four foundational drug classes (pillars of therapy) now recommended for patients with heart failure and reduced left ventricular ejection fraction, use of sodium-glucose cotransporter-2 inhibitors for those with a higher ejection fraction, and the importance of rapid initiation of life prolonging therapies once a diagnosis of heart failure has been made. Device management and other non-drug management have also evolved with the publication of new clinical trials. The review emphasizes evidence published since the recent heart failure guidelines of the European Society of Cardiology and American College of Cardiology/American Heart Association/Heart Failure Society of America in 2021 and 2022. Additional studies are needed to determine how best to implement these new interventions in clinical practice.
Phenotypes of Metabolic Dysfunction–Associated Steatotic Liver Disease–Associated Hepatocellular Carcinoma
Authors: Jesús Rivera-Esteban, Sergio Muñoz-Martínez, Mónica Higuera, Elena Sena, María Bermúdez-Ramos, Juan Bañares, María Martínez-Gomez, M. Serra Cusidó, Alba Jiménez-Masip, Sven M. Francque, Frank Tacke, Beatriz Minguez, Juan M. Pericàs
Journal: Clinical Gastroenterology and Hepatology (2024)
Graphene Quantum Dots Eradicate Resistant and Metastatic Cancer Cells by Enhanced Interfacial Inhibition
Authors: Yan Su, Kai Ye, Jinyan Hu, Zhenlin Zhang, Yang Wang, Bijiang Geng, Dengyu Pan, Longxiang Shen
Journal: Advanced Healthcare Materials (2024)

Drug-resistant and metastatic cancer cells such as a small population of cancer stem cells (CSCs) play a crucial role in metastasis and relapse. Conventional small-molecule chemotherapeutics, however, are unable to eradicate drug-resistant CSCs owing to limited interface inhibitory effects. Herein, it is reported that enhanced interfacial inhibition leading to eradication of drug-resistant CSCs can be dramatically induced by self-insertion of bioactive graphene quantum dots (GQDs) into DNA major groove (MAG) sites in cancer cells. Since transcription factors regulate gene expression at the MAG site, MAG-targeted GQDs exert greatly enhanced interfacial inhibition, downregulating the expression of a collection of cancer stem genes such as ALDH1, Notch1, and Bmi1. Moreover, the nanoscale interface inhibition mechanism reverses cancer multidrug resistance (MDR) by inhibiting MDR1 gene expression when GQDs are used at a nontoxic concentration (1/4 × half-maximal inhibitory concentration (IC
Differential Effects of Genetic Polymorphism on Comorbid Disease in Metabolic Dysfunction–Associated Steatotic Liver Disease
Authors: Yuya Seko, Kanji Yamaguchi, Toshihide Shima, Michihiro Iwaki, Hirokazu Takahashi, Miwa Kawanaka, Saiyu Tanaka, Yasuhide Mitsumoto, Masato Yoneda, Atsushi Nakajima, Takeshi Okanoue, Yoshito Itoh
Journal: Clinical Gastroenterology and Hepatology (2024)
Mutant FOXO1 controls an oncogenic network via enhancer accessibility
Authors: Hillary M. Layden, Jacob D. Ellis, Monica L. Bomber, Luke N. Bartlett, Scott W. Hiebert, Kristy R. Stengel
Journal: Cell Genomics (2024)

Transcriptional dysregulation is a hallmark of diffuse large B cell lymphoma (DLBCL), as transcriptional regulators are frequently mutated. However, our mechanistic understanding of how normal transcriptional programs are co-opted in DLBCL has been hindered by a lack of methodologies that provide the temporal resolution required to separate direct and indirect effects on transcriptional control. We applied a chemical-genetic approach to engineer the inducible degradation of the transcription factor FOXO1, which is recurrently mutated (mFOXO1) in DLBCL. The combination of rapid degradation of mFOXO1, nascent transcript detection, and assessment of chromatin accessibility allowed us to identify the direct targets of mFOXO1. mFOXO1 was required to maintain accessibility at specific enhancers associated with multiple oncogenes, and mFOXO1 degradation impaired RNA polymerase pause-release at some targets. Wild-type FOXO1 appeared to weakly regulate many of the same targets as mFOXO1 and was able to complement the degradation of mFOXO1 in the context of AKT inhibition.
Nphos: Database and Predictor of Protein <i>N</i>-phosphorylation
Authors: Ming-Xiao Zhao, Ruo-Fan Ding, Qiang Chen, Junhua Meng, Fulai Li, Songsen Fu, Biling Huang, Yan Liu, Zhi-Liang Ji, Yufen Zhao
Journal: Genomics Proteomics & Bioinformatics (2024)

Protein N-phosphorylation is widely present in nature and participates in various biological processes. However, current knowledge on N-phosphorylation is extremely limited compared to that on O-phosphorylation. In this study, we collected 11,710 experimentally verified N-phosphosites of 7344 proteins from 39 species and subsequently constructed the database Nphos to share up-to-date information on protein N-phosphorylation. Upon these substantial data, we characterized the sequential and structural features of protein N-phosphorylation. Moreover, after comparing hundreds of learning models, we chose and optimized gradient boosting decision tree (GBDT) models to predict three types of human N-phosphorylation, achieving mean area under the receiver operating characteristic curve (AUC) values of 90.56%, 91.24%, and 92.01% for pHis, pLys, and pArg, respectively. Meanwhile, we discovered 488,825 distinct N-phosphosites in the human proteome. The models were also deployed in Nphos for interactive N-phosphosite prediction. In summary, this work provides new insights and points for both flexible and focused investigations of N-phosphorylation. It will also facilitate a deeper and more systematic understanding of protein N-phosphorylation modification by providing a data and technical foundation. Nphos is freely available at http://www.bio-add.org/Nphos/ and http://ppodd.org.cn/Nphos/.
Oncolytic herpes simplex virus expressing IL-2 controls glioblastoma growth and improves survival
Authors: Praveen K Bommareddy, Hiroaki Wakimoto, Robert L Martuza, Howard L Kaufman, Samuel D Rabkin, Dipongkor Saha
Journal: Journal for ImmunoTherapy of Cancer (2024)

Background Glioblastoma (GBM), a highly immunosuppressive and often fatal primary brain tumor, lacks effective treatment options. GBMs contain a subpopulation of GBM stem-like cells (GSCs) that play a central role in tumor initiation, progression, and treatment resistance. Oncolytic viruses, especially oncolytic herpes simplex virus (oHSV), replicate selectively in cancer cells and trigger antitumor immunity—a phenomenon termed the “in situ vaccine” effect. Although talimogene laherparepvec (T-VEC), an oHSV armed with granulocyte macrophage-colony stimulating factor (GM-CSF), is Food and Drug Administration (FDA)-approved for melanoma, its use in patients with GBM has not been reported. Interleukin 2 (IL-2) is another established immunotherapy that stimulates T cell growth and orchestrates antitumor responses. IL-2 is FDA-approved for melanoma and renal cell carcinoma but has not been widely evaluated in GBM, and IL-2 treatment is limited by its short half-life, minimal tumor accumulation, and significant systemic toxicity. We hypothesize that local intratumoral expression of IL-2 by an oHSV would avoid the systemic IL-2-related therapeutic drawbacks while simultaneously producing beneficial antitumor immunity. Methods We developed G47Δ-mIL2 (an oHSV expressing IL-2) using the flip-flop HSV BAC system to deliver IL-2 locally within the tumor microenvironment (TME). We then tested its efficacy in orthotopic mouse GBM models (005 GSC, CT-2A, and GL261) and evaluated immune profiles in the treated tumors and spleens by flow cytometry and immunohistochemistry. Results G47Δ-mIL2 significantly prolonged median survival without any observable systemic IL-2-related toxicity in the 005 and CT-2A models but not in the GL261 model due to the non-permissive nature of GL261 cells to HSV infection. The therapeutic activity of G47Δ-mIL2 in the 005 GBM model was associated with increased intratumoral infiltration of CD8 + T cells, critically dependent on the release of IL-2 within the TME, and CD4 + T cells as their depletion completely abrogated therapeutic efficacy. The use of anti-PD-1 immune checkpoint blockade did not improve the therapeutic outcome of G47Δ-mIL2. Conclusions Our findings illustrate that G47Δ-mIL2 is efficacious, stimulates antitumor immunity against orthotopic GBM, and may also target GSC. OHSV expressing IL-2 may represent an agent that merits further exploration in patients with GBM.
Treating Bipolar Depression Using Psilocybin—Validity Threats Regarding Efficacy and Safety—Reply
Authors: Scott T. Aaronson, Andrew van der Vaart, Harold A. Sackeim
Journal: JAMA Psychiatry (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Advances in Thrombectomy for Acute Ischemic Stroke
Authors: Colin Derdeyn
Journal: JAMA Surgery (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
AI Imaging Analysis Needs Evaluation Before Implementation
Authors: Carolyn D. Seib, Sherry M. Wren
Journal: JAMA Surgery (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Risk of Potentially Preventable Hospitalizations After SARS-CoV-2 Infection
Authors: Diana J. Govier, Meike Niederhausen, Yumie Takata, Alex Hickok, Mazhgan Rowneki, Holly McCready, Valerie A. Smith, Thomas F. Osborne, Edward J. Boyko, George N. Ioannou, Matthew L. Maciejewski, Elizabeth M. Viglianti, Amy S. B. Bohnert, Ann M. O’Hare, Theodore J. Iwashyna, Denise M. Hynes, Theodore Berkowitz, Jacob Doll, Breana Floyd, Susan Nicole Hastings, Eric Hawkins, Makoto Jones, Lee Kamphius, Abby Moss, Michael Ong, Sarah Seelye, Javeed Shah, Troy Shahoumian, Aasma Shaukat, Megan Shepherd-Banigan, Christopher Slatore, Battista Smith, Pradeep Suri, Alan Teo, Kelly Vranas, Kara Winchell, Edwin Wong, Kristin Wyatt
Journal: JAMA Network Open (2024)

Research demonstrates that SARS-CoV-2 infection is associated with increased risk of all-cause hospitalization. However, no prior studies have assessed the association between SARS-CoV-2 and potentially preventable hospitalizations-that is, hospitalizations for conditions that can usually be effectively managed in ambulatory care settings.
Chronic Mucocutaneous Candidiasis Due to <i>STAT1</i> Gene Variant
Authors: Danrui Jing, Guanzhao Liang, Xiaofang Li
Journal: JAMA Dermatology (2024)

This case report describes a man in his 40s who presented with a 5-month history of recurrent pruritic papular erythema with mild scaling on the face, left forearm, and groin.
Striking racial inequities in health persist in South Africa
Authors: Anthony Mbewu, David R Williams, Relebohile Moletsane, Priscilla Reddy
Journal: BMJ (2024)

In 1994, when 350 years of colonialism and apartheid in South Africa came to an end and more than 300 racist laws were repealed, many people expected to see a significant decline in racial inequalities in the country's health.
“Medication is binary, but gender expressions are often not”—the Hilary Cass interview
Authors: Kamran Abbasi
Journal: BMJ (2024)

Your report describes a very complex situation.But at its heart is a concern for the wellbeing of young people?Children and young people with gender related distress have been poorly served because we've exceptionalised them.Health professionals are nervous to see them in local services and so they have often been bypassed straight through to the Gender Identity Development Service at the Tavistock and Portman, whose waiting list has grown exponentially.Many have neurodiversity or other mental health problems that you would expect somebody to address locally.But if health professionals feel they can't see them, then they sit on this long waiting list.And by the time they are seen, all of this has got much worse.
Recommendations for Post-Operative RadioTherapy After Complete Resection of Thymoma—a French DELPHI Consensus Initiative
Authors: Clémence Basse, Jonathan Khalifa, François Thillays, Cécile Le Pechoux, Jean-Michel Maury, Pierre-Emmanuel Bonte, Alexandre Coutte, Nicolas Pourel, Vincent Bourbonne, Olivier Pradier, Aurélie Belliere, Florence Le Tinier, Mélanie Deberne, Ronan Tanguy, Fabrice Denis, Laetitia Padovani, Audrey Zaccariotto, Thierry Molina, Lara Chalabreysse, Geoffrey Brioude, Bertrand Delatour, Jean-Christophe Faivre, Kim Cao, Philippe Giraud, François-Georges Riet, Sébastien Thureau, Delphine Antoni, Carole Massabeau, Audrey Keller, Emilie Bonnet, Delphine Lerouge, Etienne Martin, Nicolas Girard, Angela Botticella
Journal: Journal of Thoracic Oncology (2024)
<i>In Vivo</i> Tissue Distribution of Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice
Authors: Marcus M. Garcia, Aaron S. Romero, Seth D. Merkley, Jewel L. Meyer-Hagen, Charles Forbes, Eliane El Hayek, David P. Sciezka, Rachel Templeton, Jorge Gonzalez-Estrella, Yan Jin, Haiwei Gu, Angelica Benavidez, Russell P. Hunter, Selita Lucas, Guy Herbert, Kyle Joohyung Kim, Julia Yue Cui, Rama R. Gullapalli, Julie G. In, Matthew J. Campen, Eliseo F. Castillo
Journal: Environmental Health Perspectives (2024)

Global plastic use has consistently increased over the past century with several different types of plastics now being produced. Much of these plastics end up in oceans or landfills leading to a substantial accumulation of plastics in the environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled or ingested by both animals and humans. A growing body of evidence indicates that MPs can cross the gut barrier and enter into the lymphatic and systemic circulation leading to accumulation in tissues such as the lungs, liver, kidney, and brain. The impacts of mixed MPs exposure on tissue function through metabolism remains largely unexplored.
Integrating Upper-Limb Prostheses with the Human Body: Technology Advances, Readiness, and Roles in Human–Prosthesis Interaction
Authors: He (Helen) Huang, Levi J. Hargrove, Max Ortiz-Catalan, Jonathon W. Sensinger
Journal: Annual Review of Biomedical Engineering (2024)

Significant advances in bionic prosthetics have occurred in the past two decades. The field's rapid expansion has yielded many exciting technologies that can enhance the physical, functional, and cognitive integration of a prosthetic limb with a human. We review advances in the engineering of prosthetic devices and their interfaces with the human nervous system, as well as various surgical techniques for altering human neuromusculoskeletal systems for seamless human–prosthesis integration. We discuss significant advancements in research and clinical translation, focusing on upper limbprosthetics since they heavily rely on user intent for daily operation, although many discussed technologies have been extended to lower limb prostheses as well. In addition, our review emphasizes the roles of advanced prosthetics technologies in complex interactions with humans and the technology readiness levels (TRLs) of individual research advances. Finally, we discuss current gaps and controversies in the field and point out future research directions, guided by TRLs.