tbuckley/cabot-search huggingface dataset:
PITX2 methylation and biochemical recurrence in postradical prostatectomy prostate cancer patients
Authors: E. Heiden, G. Weiss, L. Banez, S. Freedland, L. Sun, A. Hartmann, G. van Leenders, C. Bangma, M. Ittmann, T. Wheeler
Journal: Journal of Clinical Oncology (2009)

5124 Background: PITX2 is a bicoid-related transcription factor induced by the Wnt pathway and required for effective cell-type-specific proliferation during development. We previously reported prognostic potential of PITX2 gene promoter methylation for outcome prediction in breast and prostate cancer (PC) patients. Radical prostatectomy (RP) is potentially curative in patients with clinically localized PC. However, biochemical recurrence (BCR) affects 15–30% of patients undergoing RP. In the current study, we validate PITX2 methylation status as a predictor of BCR following RP. Methods: PITX2 methylation status was assessed in formalin-fixed paraffin-embedded RP tumor tissue samples from 476 patients from four different institutions in USA and Europe using customized microarrays. Associations between PITX2 methylation and BCR were assessed using log-rank test and Cox regression controlling for PC features. Results: In multivariate analysis, patients with a high methylation status were at significantly higher risk for BCR compared to patients with low methylation status (HR = 3.0; 95%CI = 2.0–4.5; p &lt; 10 -5 ). BCR-free survival at five years after surgery was 85% and 61% for patients in the low and high methylation group, respectively. In patients with pathological Gleason 7 tumors, the relative risk of suffering BCR was twice as high for a patient with high PITX2 methylation relative to patients with low PITX2 methylation (HR = 2.0; 95%CI = 1.2–3.3; p = 0.005). Moreover, PITX2 methylation status was significant in the group of patients with tumor involvement of the surgical margins in the prostatectomy specimen. (HR = 3.36, 95% CI: 2.24–5.06, p = 0.001). Conclusions: PITX2 methylation status identifies PC patients most likely to experience BCR. This test independently adds to prognostic information provided by standard clinico-pathological analyses improving stratification of RP patients into high- or low-risk for BCR. This new clinical tool would be of particular benefit in assessment of intermediate-risk patients (Gleason 7) or patients with positive surgical margins wherein risk stratification remains a challenge. [Table: see text]
Abstract 19939: Prolonged Hyperoxic Ventilation After Cardiopulmonary Resuscitation Aggravates Striatal Brain Damage
Authors: Anne Brucken, Kai Kottmann, Rolf Rossaint, Kay Wilhelm Nolte, Joachim Weis, Michael Fries
Journal: Circulation (2010)

Purpose: Current guidelines encourage the use of 100% O2 during resuscitation and for an undefined period thereafter even though previous data indicate that pure oxygen ventilation during early rep...
Clinical Diabetes: Modern Management.
Authors: Stephen Podolsky
Journal: Annals of Internal Medicine (1980)

This comprehensive work, with a large number of contributors, provides a basis for study in surgical science and serves well to update the scientific basis of the experienced clinician.Like most multi-author works, the amount of detail covered in different sections varies enormously, and one must wonder why the editors have not produced more balance.In some sections a truly scientific approach is clear, whereas in others contentious or unverified work and concepts are presented, no doubt in the interests of brevity and clarity, in a manner which could suggest
Abstract 5384: Acute Lipid Infusion Causes Macrophage Infiltration, Local Inflammation, and Suppresses AMPK in Heart
Authors: Hwi Jin Ko, Dae Young Jung, Jason K Kim
Journal: Circulation (2008)

Obesity and hyperlipidemia are major risk factors of heart disease. Recent studies showed that inflammation is associated with obesity and plays a role in the pathogenesis of diabetic complications. In this report, we examined the effects of lipid on cardiac inflammation and metabolism. Intralipid (2.5 ml/kg/hr; triglyceride emulsion) and heparin (6 U/hr) or glycerol (control) were intravenously infused for 5 hrs to raise circulating fatty acids (FFA) levels in awake C57BL/6 mice (n=10~11). Plasma FFA levels were raised by 3.5-fold over the glycerol-infused groups, and heart samples were taken at the end of experiments. Acute lipid infusion caused cardiac inflammation and increased local macrophage-specific CD68 levels in heart (Fig. 1 ; * P &lt;0.05). Local levels of cytokines (IL-6 and TNF-α) were elevated by ~2-fold following lipid infusion (Fig. 2 ). Heart expression of the C-C motif chemokine receptor-2 (CCR2), which binds the MCP-1 was elevated by 70% following lipid infusion, and this was associated with increased levels of MyD88 in heart, supporting the role of TLR4 signaling in lipid-induced cardiac inflammation. Lipid-induced elevation of local cytokine levels resulted in increased cardiomyocyte expression of SOCS3 (Fig. 3 ). Further, acute lipid infusion reduced total AMPK protein levels and Thr 172 phosphorylation of AMPK in heart (Fig. 4 ). These data are consistent with the role of inflammation in the regulation of myocardial AMPK. Our findings indicate that fatty acids and nutrient stress are involved in obesity-induced cardiac inflammation and alterations in myocardial glucose metabolism.
Identifying predictors of taxane-induced peripheral neuropathy using shotgun proteomics technology.
Authors: Meghna S. Trivedi, Emily I. Chen, Danielle Awad, Antonius Koller, Purvi Patel, Kevin Kalinsky, Matthew A. Maurer, Katherine D. Crew, Dawn L. Hershman
Journal: Journal of Clinical Oncology (2015)

9607 Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of taxanes. Advances in proteomic technologies incorporating mass spectrometry (MS) for biomarker discovery show great promise in providing molecular profiles from complex biological samples. We evaluated the association between protein cargos in serum exosomes and severity of CIPN. Methods: We conducted a nested case-control study within a prospective cohort of women with early stage breast cancer receiving adjuvant taxane chemotherapy. Neuropathy was assessed at baseline, completion of taxane, and 6 and 12 months after taxane completion using the Functional Assessment of Cancer Therapy-GOG-Neurotoxicity (FACT-Ntx) score (range 0-44). Blood samples were collected at baseline, completion of taxane, and 12 months. The changes in FACT-Ntx score from baseline to follow-up time points were used to identify 2 groups of subjects: those with no change in FACT-Ntx score (N = 8) and those with a ≥ 20% worsening in FACT-Ntx score (N = 8). MS-based proteomics technology was used to identify proteins present in serum exosomes and potential biomarkers for CIPN. One-way ANOVA analysis with p < 0.05 as the threshold cutoff for statistical significance was applied using the Qlucore Omics Explorer to identify biomarkers predictive of developing CIPN. Results: From the serum exosomes derived from this cohort, MS-based proteomics technology identified over 700 proteins known to be in different subcellular locations (e.g., 32% cytoplasm and 19% nucleus) and have different functions (e.g.,15% enzymes, 6.8% transcription regulators, and 5% kinases). We found a 12-protein signature from the baseline serum samples that can be used to distinguish between patients with or without CIPN after taxane treatment (p < 0.05) suggesting that the baseline samples can predict subsequent neurotoxicity. Conclusions: We were able to identify a serum exosomal profile that is associated with taxane-induced peripheral neuropathy. We believe that this new panel of biomarkers could be used to identify patients at high risk of developing severe CIPN. We plan to validate the 12-protein profile in a larger cohort of patients who have received taxane therapy.
Annual Review of Nutrition.
Authors: William J. Darby, Robert E. Olson, Donald B. McCormick, Robert J. Cousins, Dennis M. Bier, Barbara A. Bowman, Patrick J. Stover, Rudi Balling
Journal: Annals of Internal Medicine (1985)

Annual Review Of Nutrition , Annual Review Of Nutrition , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Illustrated Atlas of Cutaneous Surgery
Authors: Jessica L. Fewkes, Sheldon V. Pollack, Mack L. Cheney
Journal: Annals of Internal Medicine (1992)

Part 1 Patient preparation: informed consent antisepsis surgical facility anesthesia. Part 2 Basic skills: biopsy curettage electrosurgery cryosurgery suturing hemostasis. Part 3 Excision techniques: simple complex wedge grafts flaps healing by secondary intention dressings complications. Part 4 Other surgical techniques: Mohs nail dermabrasion and chemical peel acne scar surgery sclerotherapy collagen, fibrel, silicone, microlip injury rhinophyma co2 laser punch hair transplant surgery keloid surgery.
THE PLEASURES OF IGNORANCE
Authors: Robert Lynd
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pictures of Health: A Photographic History of Health Care in Philadelphia: 1860-1945
Authors: Janet Lynne Golden, Charles E. Rosenberg
Journal: Annals of Internal Medicine (1992)

Having forgiven his significant contribution to quackery-the promotion of an infamous "powder of sympathy" that healed without coming into contact with the wound-historians in this century have worked successfully to establish Sir Kenelm Digby as one of the great early experimental philosophers.His reputation is now based primarily on his Two treatises (1644), in which an early defence of Harvey and revolutionary accounts of the nervous system and epigenesis are found in a work credited with introducing continental atomistic theories into England.He also wrote extensively on other subjects, including politics, literature, natural history and religion.Tracking down nearly 150 editions of Digby's twenty or so books, sometimes anonymous, sometimes published abroad, cannot have been an easy task, and the present bibliography is certainly the fullest and most detailed record of the oeuvre that has hitherto appeared.By the evidence presented in it, one work traditionally ascribed to Sir Kenelm, The royall apologie (1648), may with more reason be attributed to his brother George Digby .Most of the entries give adequate details of each book's title, imprint, collation and pagination; significant variants have been noted; and general introductions to each title neatly summarize the nature and status of its contents.Sadly, however, the end product is marred by two facts that should have been made explicit in the title.Firstly, the Californian anaesthesiologist Kenneth Garth Huston was, naturally enough, unable to acquire all the books by, about, or relating to the object of his enthusiasm.Instead of using his collection as an unparalleled opportunity for further research, the editor takes only brief notice of editions not in Dr Huston's library, and leaves some sections (on manuscript sources, and Digby's own library, for example) manifestly incomplete.This fault springs no doubt from the other great disappointment facing the reader who expects a straight work of scholarship, namely that the bibliography is actually a disguised sales catalogue, in which many of the notes are put to the service of selling Dr Huston's Digby collection in individual lots (prices available on request).
Swine influenza A (H1N1) infection in two children - Southern California, March-April 2009.
Authors: M. Ginsberg, J. Hopkins, A. Maroufi, G. Dunne, D. R. Sunega, J. Giessick, P. McVay, K. Lopez, P. Kriner, S. Munday, K. Harriman, B. Sun, G. Chavez, D. Hatch, R. Schechter, D. Vugia, J. Louie, W. Chung, N. Pascoe, S. Penfield, J. Zoretic, V. Fonseca, P. Blair, D. Faix, J. Tueller
Journal: MMWR Morbidity and Mortality Weekly Report (2009)
The Purification of Public Water Supplies.
Authors: John Willmuth Hill
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicine Man in China
Authors: Albert. Gervais
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal Function: Transactions of the Second Conference, October 19-20, 1950, New York, N. Y
Authors: Stanley E. Bradley
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2808: Combination of Adenosine Stress Perfusion and Late Enhancement Cardiac Magnetic Resonance Imaging in Patients with Suspected Coronary Artery Disease, Percutaneous Coronary Intervention and Coronary Bypass Graft -A Multi-Center Study
Authors: Peter Bernhardt, Guenter Pilz, Jochen Spiess, Berthold Hoefling, Vinzenz Hombach, Oliver Strohm
Journal: Circulation (2008)

The combination of stress perfusion and late Gadolinium enhancement (LGE) cardiac magnetic resonance imaging (CMR) has been established for diagnosis of myocardial ischemia. However, little is known about this helpful clinical examination tool in patients who were treated by percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG). Aim of our study was to compare the diagnostic accuracy of stress perfusion and LGE in patients with suspected coronary artery disease (CAD), with PCI and with CABG in a multi-center trial. 477 patients with suspected CAD, 209 with PCI and 110 with CABG were included to the study and underwent adenosine stress perfusion and LGE 10 min. after a second bolus of contrast agent. CMR images were assessed visually using the 16-segments model. Myocardial ischemia was defined as resgional hypoenhancement in stress perfusion with absent LGE. All patients underwent coronary angiography. A significant stenosis was defined by QCA in case of ≥70% of coronary artery or bypass graft narrowing in vessels ≥2 mm diameter. A relevant vessel stenosis or occlusion was present in 173 (36%) patients with susptectd CAD, 69 (29%) PCI and 71 (65%) CABG patients. PCI was performed 314±231 and CABG 423±275 days before CMR examination. Sensitivity, specificity and overall accuracy per patient are given in table 1 CMR is feasible and suitable for detecting relevant vessel stenosis in patients who previously were treated by PCI or CABG. Diagnostic accuracy is reduced in patients with CABG. This could be due to different flow and perfusion kinetic. Furthermore, presented evaluation method may be inadequate, since collaterals and different perfusion territories are not taken into consideration. CMR yields similar diagnostic accuracy in patients with suspected CAD and those who previously were treated by PCI.
18F-Fluciclovine PET/CT for the Detection of Prostate Cancer Relapse
Authors: Cristina Nanni, Riccardo Schiavina, Eugenio Brunocilla, Stefano Boschi, Marco Borghesi, Lucia Zanoni, Cinzia Pettinato, Giuseppe Martorana, Stefano Fanti
Journal: Clinical Nuclear Medicine (2015)

In recent years, a new PET compound (anti-3-(18)F-FACBC or (18)F-fluciclovine) was tested for the detection of prostate cancer relapse. Despite very promising results, only preliminary data were available with regard to the comparison to (11)C-choline. The aim of this study was to compare the detection rate of (18)F-FACBC and (11)C-choline in patients presenting a biochemical relapse.Fifty patients radically treated for prostate cancer and presenting with rising prostate-specific antigen (PSA) levels were consecutively and prospectively enrolled. All the patients were out of hormonal therapy and underwent both (11)C-choline PET/CT and (18)F-fluciclovine PET/CT within 1 week. The results were compared in terms of detection rate on a patient and lesion basis. Furthermore, a more detailed analysis regarding local, lymph node, and bone relapse was performed.On a patient-based analysis, (18)F-fluciclovine detection turned out to be significantly superior to (11)C-choline (P < 0.000001). This result was also true on lesion, lymph node, bone lesion, and local relapse analysis (P < 0.0001 in all the cases). There was no significant difference in terms of target to background of positive lesions between (11)C-choline and (18)F-fluciclovine. When the patients were divided into groups with different PSA levels, (18)F-fluciclovine had a superior detection rate for low, intermediate, and high PSA levels.In our experimental conditions, (18)F-fluciclovine provided a statistically significant better performance in terms of lesion detection rate as compared with (11)C-choline. However, more studies are required to evaluate the clinical significance of these results in terms of sensitivity, specificity, and accuracy.
Short-Term and Long-Term Clinical Impact of Stent Thrombosis and Graft Occlusion in the SYNTAX Trial at 5 Years
Authors: Vasim Farooq, Patrick W. Serruys, Yaojun Zhang, Michael Mack, Elisabeth Ståhle, David R. Holmes, Ted Feldman, Marie-Claude Morice, Antonio Colombo, Christos V. Bourantas, Ton de Vries, Marie-angèle Morel, Keith D. Dawkins, Arie Pieter Kappetein, Friedrich W. Mohr
Journal: Journal of the American College of Cardiology (2013)
Current Issues in Cancer: Genes dreams and cancer
Authors: K Sikora
Journal: BMJ (1994)

There have been tremendous advances in our understanding of cancer from the application of molecular biology over the past decade. The disease is caused by a series of defects in the genes that accelerate growth--oncogenes--and those that slow down cellular turnover--tumour suppressor genes. The proteins they encode provide a promising hunting ground in which to design and test new anticancer drugs. Several treatment strategies are now under clinical trial entailing direct gene transfer. These include the use of gene marking to detect minimal residual disease, the production of novel cancer vaccines by the insertion of genes which uncloak cancer cells so making them visible to the host's immune system, the isolation and coupling of cancer specific molecular switches upstream of drug activating genes, and the correction of aberrant oncogenes or tumour suppressor genes. The issues in these approaches are likely to have a profound impact on the management of cancer patients as we enter the next century.