tbuckley/cabot-search huggingface dataset:
Abstract 5790: High Levels of Homocysteine and D-dimer Are Associated With Faster Functional Decline Among Men and Women With Lower Extremity Peripheral Arterial Disease
Authors: Mary M McDermott, Kiang Liu, Luigi Ferrucci, Lu Tian, Jack Guralnik, Huimin Tao, Paul Ridker, Michael Criqui
Journal: Circulation (2009)

BACKGROUND. We assessed associations of baseline biomarker levels with functional decline among participants with lower extremity peripheral arterial disease (PAD). METHODS. Participants were 352 men and women with an ankle brachial index (ABI) &lt; 0.90 who attended a baseline and up to three annual follow-up visits. Baseline levels of homocysteine, C-reactive protein (CRP), interleukin-6 (IL-6), and D-dimer were obtained. Participants performed a six-minute walk test and the short physical performance battery (SPPB) at baseline and annually. The SPPB is a composite measure of lower extremity functioning scored on a 0 –12 scale (12= best). Outcomes were average annual decline in six-minute walk distance, average annual decline in the SPPB, and mobility loss. Mobility loss was defined as becoming unable to walk 1/4 mile or walk up and down one flight of stairs without assistance, among those without baseline mobility limitations. Results adjust for age, sex, race, body mass index, ABI, smoking, comorbidities, and other potential confounders. RESULTS . The 352 participants were average age 75±8 and 47% were women. The average ABI was 0.63 ± 0.16 and 33% had diabetes mellitus. Average baseline six-minute walk distance and SPPB scores were 1,101 feet ± 432 and 9 ± 3, respectively. Adjusting for confounders, higher CRP levels were associated with more rapid decline in six-minute walk performance (1 st (lowest) Tertile -50 feet/year; 2 nd Tertile -44 feet/year; 3 rd (highest) Tertile -65 feet/year, p trend value = 0.04). Higher CRP levels were also associated with more rapid decline in the SPPB (1 st (lowest) Tertile 0.3/year; 2 nd Tertile -0.3/year; 3 rd (highest) Tertile -0.5/year, p trend = 0.02). Similarly, higher levels of homocysteine were associated with more rapid decline in the SPPB (1 st Tertile 0.3/year; 2 nd Tertile -0.4/year; 3 rd Tertile -0.5/year, p trend = 0.03). Higher levels of homocysteine were also associated with higher rates of mobility loss, p trend = 0.04). IL-6 and D-dimer were not significantly associated with declining functional performance. CONCLUSIONS . This study demonstrates, for the first time, that higher baseline levels of CRP and homocysteine are associated with faster rates of decline in functional performance among men and women with PAD.
Abstract 6017: Long-Term TAXUS Paclitaxel-Eluting Stent Outcomes in the Elderly Patients
Authors: Daniel E Forman, Jeanne Y Wei, Mark I Friedman, Keith D Dawkins, Donald S Baim
Journal: Circulation (2008)

Although percutaneous coronary intervention (PCI) with drug-eluting stents (DES) is widely used for treating elderly patients (pts), there are limited data regarding PCI outcomes in this high-risk patient population. To determine the impact of age on long-term safety and efficacy following implantation of the TAXUS Express 2 paclitaxel-eluting stent, we analyzed the TAXUS and ARRIVE studies. The 2,797 pts in TAXUS I, II SR, IV and V randomized trials and 7,492 pts in ARRIVE 1 and 2 “real world” registries were divided into three groups based on age: &lt;60, 60 –70 and &gt;70 years. Safety and efficacy outcomes were compared among these age groups. Results: While the 5-year death rate increased with age in the TAXUS trials, the rates of target lesion revascularization (TLR) and myocardial infarction (MI) were comparable, and the rate of stent thrombosis (ST) decreased with age. Moreover, the bare metal stent pts &gt;70 (not shown) had similar rates of death and MI and a higher rate of TLR and ST than the corresponding TAXUS cohort. In “real world” higher risk ARRIVE pts, the 2-year death rate and cardiac death rate also increased with age while the rates of TLR, MI, and ST actually decreased with age. Elderly pts (age &gt;70) treated with the TAXUS Express 2 stent had higher long-term death rates, but comparable TLR and MI rates and reduced ST rates compared to their younger counterparts. Collectively, these results indicate that despite the high-risk clinical and angiographic characteristics commonly observed in elderly pts, this patient population derives similar safety and efficacy from TAXUS stent treatment and such treatment should not be withheld on the basis of age alone when clinically and anatomically appropriate.
Abstract 3397: The Long Pentraxin PTX3 Exacerbates Pressure Overload-induced Left Ventricular Dysfunction
Authors: Satoshi Suzuki, Tetsuro Shishido, Tatsuro Kitahara, Toshiki Sasaki, Shigehiko Kato, Mitsunori Ishino, Tetsu Watanabe, Yasuchika Takeishi, Isao Kubota
Journal: Circulation (2009)
Abstract 13023: Differential Correlation Between Measures of Severity of Aortic Valve Stenosis and Body Size
Authors: Jan Minners, Christa Gohlke-Baerwolf, Rolf-Peter Kienzle, Franz-Josef Neumann, Nikolaus Jander
Journal: Circulation (2011)

Background:  Jet velocity (Vmax), mean pressure gradient (MPG), and aortic valve area (AVA) are commonly used measures for the assessment of the severity of aortic valve stenosis with, for example, severe stenosis defined by a Vmax >4.0m/s, MPG >40mmHg, and an AVA 2 . Since patients of different body size require different valve areas, a cut-off value indexed to body surface area (AVAindex 2 /m 2 ) is often preferred. Albeit widely adopted in the literature, very limited information is available on the validity of indexing aortic valve area by body surface area particularly in patients with valve stenosis; and, in fact, this approach has repeatedly been questioned. We therefore set out to investigate the need for and the effects of indexation by measures of body size in patients with significant aortic valve stenosis.   Methods and Results:  Echocardiographic and anthropometric data from 2913 consecutive patients with a jet velocity ≥2.5m/s and normal left ventricular function were analysed. Forty-eight percent were female, mean age 73±10years, body surface area 1.9±0.2m 2 , Vmax 4.1±0.9m/s, MPG 40.4±17.6mmHg, AVA 0.89±0.32cm 2 , and AVAindex 0.47±0.16cm/m 2 . Jet velocity and MPG were independent of body surface area as indicated by a correlation coefficient of 0.072 and 0.073, respectively. In contrast, calculation of AVA based on the continuity equation introduced a significant correlation with body surface area (r=0.312, p   Conclusion:  Jet velocity as a measure of aortic valve stenosis is independent of body surface area. Calculation of AVA introduces a significant correlation with body size which can be removed by indexing for body surface area.
Abstract 2102: Mechanism of Atrial Tachycardias Following Left Atrial Ablation of Atrial Fibrillation
Authors: Sanders Chae, Hakan Oral, Eric Good, Alan Wimmer, Sujoya Dey, Elizabeth Huether, Frank Pelosi, Frank Bogun, Fred Morady, Aman Chugh
Journal: Circulation (2006)

Background: Patients who undergo left atrial (LA) ablation of atrial fibrillation (AF) may develop organized atrial tachycardia (AT) during follow up. The mechanism of AT is not well described. Obj...
Abstract 10457: Inability of the 150mg Maintenance Dose of Clopidogrel to Prevent Increased Mortality After Drug-eluting Stents in Patients With High Platelet Reactivity on Standard-dose Clopidogrel
Authors: Dietmar Trenk, Christian M Valina, Katja Allgaier, Willibald Hochholzer, Stefan Leggewie, Christian Stratz, Rolf-Peter Kienzle, Heinz-Joachim Buettner, Franz-Josef Neumann
Journal: Circulation (2010)
Abstract 109: Patients with Diabetes Have Decreased Survivability with Good Neurological Outcomes After Out-of-Hospital Cardiac Arrest
Authors: Beatrice Dayea Jang, Sang Do Shin, William McClellan, Bryan McNally
Journal: Circulation (2014)

Objectives: This study aims to provide a scientific evidence of the association between diabetes and the probability of OHCA survival with good neurological outcomes. Methods: Korean registry on patients survived to admission after emergency medical services (EMS)-assessed OHCA with cardiac etiology with known diabetes statuses (2009 to 2012) was used. We excluded patients without available hospital outcomes or diabetes. Diabetes was defined when the patients had history of treatment or diagnosis or positive result at laboratory test during hospital stay. Outcomes were survival to discharge with good brain recovery measured by medical record review by medical record review experts using cerebral performance category 1 or 2. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a multivariate logistic regression model adjusting for individual, Utstein, post-resuscitation factors, and comorbidities. Interaction model between diabetes and gender and heart disease were also analyzed. Results: Total 7463 patients including diabetes 1,952 (26.2%), non-diabetes 4,129 (55.3%), and unknown diabetes 1,382 (18.5%) were finally analyzed. Survival to discharge with good brain recovery was 17.7% in non-diabetes, 9.7% in diabetes 16.2% in unknown-diabetes, respectively (p&lt;0.001). Crude OR (95% CI) was 0.50 (0.42-0.59) in diabetes and 0.89 (0.76-1.05) in unknown-diabetes comparing with non-diabetes. Adjusted OR (95% CI) was 0.78 (0.61-0.98) in diabetes and 1.07 (0.75-1.53) in unknown-diabetes comparing with non-diabetes. The adjusted OR measuring the effect of diabetes on survival with good neurological outcomes for male with history of heart disease was 0.32 (0.22-0.48, p-value &lt;0.0001), for male without history of heart disease was 0.55 (0.34-0.89, p-value &lt;0.0001), for female with history of heart disease was 0.60 (0.48-0.76, p-value 0.0152), and for female without history of heart disease was 1.03 (0.71-1.47, p-value 0.8919). Conclusion: This study provides evidence of significant associations of diabetes and decreased OHCA survivability with good neurological outcomes where the association is greater in male and patients with heart disease.
Abstract 4150: Exercise Training Restores Baroreflex Control of Sympathetic Nerve Activity in Hypertensive Patients
Authors: Mateus C Laterza, Luciana D Matos, Maria J Alves, Ana M Braga, Fabiana Roveda, Ivani C Trombetta, Eduardo M Krieger, Carlos E Negrao, Maria Rondon
Journal: Circulation (2006)
Plasma atrial natriuretic peptide concentration inversely correlates with left atrial collagen volume fraction in patients with atrial fibrillation
Authors: Fumiki Yoshihara, Toshio Nishikimi, Yoshikado Sasako, Jun Hino, Junjiro Kobayashi, Kenji Minatoya, Ko Bando, Yoshio Kosakai, Takeshi Horio, Shin-ichi Suga, Yuhei Kawano, Hiroaki Matsuoka, Chikao Yutani, Hisayuki Matsuo, Soichiro Kitamura, Tohru Ohe, Kenji Kangawa
Journal: Journal of the American College of Cardiology (2002)
Abstract 3265: Prevention of Dystrophin Cleavage by Protease 2A Protects Against Coxsackieviral Protease 2A Mediated Cardiomyopathy
Authors: ByungKwan Lim, Dingding Xiong, Toshitaka Yajima, Angela K Peter, Kyung-Kuk Hwang, Kirk U Knowlton
Journal: Circulation (2009)

It has been previously demonstrated that dystrophin is cleaved in the cardiac myocyte by the viral protease 2A following infection with Coxsackievirus B3 (CVB3). In addition, it has been shown that...
Abstract 16720: Induction of Notch Activity Promotes a Cardiac Differentiated Phenotype in Adult Cardiac Progenitor Cells
Authors: Natalie A Gude, Kimberlee Fischer, Silvia Truffa, Brandi Bailey, Daniele Avitabile, Anya Joyo, Eri Joyo, Mark A Sussman
Journal: Circulation (2011)

Introduction: Notch is a critical mediator of heart development, stem cell self-renewal and specification; appropriate timing and levels of Notch signaling are essential for proper cell fate determination. However, constitutive activation of Notch does not recapitulate the physiological signal driving cardiac differentiation. Hypothesis: Controlled pulses of Notch activation enhance cardiac differentiation in CPCs. Methods: Ligand-regulated or tetracycline inducible versions of intracellular Notch designed to control timing and activation level were engineered into cultured adult cardiac progenitor cells (CPCs). Stable CPC lines were created carrying constructs for GFP (CPCe), ligand-regulated intracellular Notch (CPCeK), or tetracycline inducible intracellular Notch (CPCtetKmER). Induction was performed using 1 µM tamoxifen and/or 1 µM doxycycline with proliferation measured over a period of 6 days. Markers of Notch signaling and cardiac differentiation were assessed by quantitative PCR, immunoblotting, or immunostaining up to 6 days after induction. Results: Increased levels of hey1, jagged1, cardiac troponin T (cTnT) and smooth muscle actin (SMA) transcripts were observed following one day of Notch induction in CPCeK and CPCtetKmER. Changes indicative of differentiation were present in CPCeKs and CPCtetKmERs following one week after Notch induction including flattened and enlarged morphology, elevated levels of smooth muscle actin (SMA) and jagged1 mRNA, and expression of SMA protein. Proliferation decreased after three days of sustained Notch signaling. Conclusions: Notch signaling promotes CPCs to acquire phenotypic characteristics of smooth muscle or myocyte differentiation. Engineering CPCs allows for appropriate “physiologic” temporal control to regulate the potent cardiogenic activity of Notch signaling. Regulation of Notch activity in CPCs utilizing temporal and reversible expression will enhance commitment and differentiation when utilized in conjunction with cell based therapy for heart disease, thereby enhancing myocardial regeneration and repair.
Abstract 14420: Supraventricular Arrhythmias in Patients with Cardiac Sarcoidosis: Prevalence, Predictors and Clinical Implications
Authors: Luciano J Pastori, Juan F Viles-Gonzalez, Juan P Wisnivesky, Avi Fischer, Martin Goldman, Davendra Mehta
Journal: Circulation (2011)

Background: Cardiac sarcoidosis is known to be associated with congestive heart failure, conduction disorders, and tachyarrhythmias. Ventricular arrhythmias are the most feared cardiac manifestatio...
Abstract 20028: Preoperative Stroke Volume Accurately Predicts Outcome After Aortic Valve Replacement In Patients With Severe Aortic Regurgitation
Authors: Mario Senechal, Mathieu Bernier, Michelle Dubois, Ariane Lemieux, Fran cois Dagenais, Pierre Voisine
Journal: Circulation (2010)

ABSTRACT Background In most patients with aortic regurgitation (AR), valve replacement results in favorable left ventricular (LV) remodeling and normalization of LV ejection fraction (LVEF) at dist...
Abstract 3407: The Transcriptional Mediator Complex Is Essential For Cardiac Valve Formation
Authors: Steffen Just, Ina Berger, Benjamin Meder, David Hassel, Alexander Hess, Hugo A Katus, Wolfgang Rottbauer
Journal: Circulation (2008)

The genetic causes of congenital heart diseases especially cardiac valve disorders are mostly unknown. During the last decade, the zebrafish became an excellent and established model organism (1) to uncover these genetic defects and (2) to elucidate the underlying molecular pathomechanisms. We recently isolated the zebrafish mutation ping pong ( png m683 ) in a large-scale ENU-mutagenesis screen for recessive lethal mutations that perturb cardiac function. png mutant zebrafish embryos show pathologically developed cardiac valves. Due to malformation of the cardiac AV valves, png mutant zebrafish embryos exhibit vigorous regurgitation of blood between the atrium and the ventricle. Furthermore, as a result of the cardiac valve malformation and cardiac dysfunction png mutants die at day 6 post fertilization. Expression of several factors known to be crucial for the proper development and formation of the atrio-ventricluar canal (e.g. notch1b, bmp4 or versican) is significantly altered in png mutant zebrafish hearts. By a positional cloning approach we demonstrate that the ping pong phenotype is caused by a promotor mutation in a zebrafish gene encoding for a novel component of the “transcriptional mediator complex”. This mediator complex is a multi-protein complex that acts as a transcriptional coactivator and transduces informations from transcription factors to the RNA polymerase II. png is strongly expressed in zebrafish as well as human cardiomyocytes. Furthermore, sequence alignments demonstrate the evolutionary conservation of the ping pong gene product. Gene specific knock-down studies by means of modified antisense oligonucleotides reveal a phenocopy of the png mutant phenotype whereas injection of the gene-specific mRNA in png mutant embryos restores the mutant phenotype indicating that png is indeed responsible for the observed phenotype. The zebrafish evolved as an excellent model organism to study the molecular signalling pathways involved in cardiac valve formation. By detailed characterization of the zebrafish line ping pong we will obtain new insights into these molecular mechanisms especially the transcriptional control of valve formation and therefore the pathomechanisms of human cardiac valve disorders.
Abstract 1224: Rock1 Deletion Prevents Cardiac Dilation And Improves Contractile Function In Pathological Cardiac Hypertrophy
Authors: Jianjian Shi, Yi-Wei Zhang, Gerald W Dorn, Lei Wei
Journal: Circulation (2007)

The development of left ventricular cardiomyocyte hypertrophy in response to increased hemodynamic load and neurohormonal stress is initially a compensatory response. However, persistent stress eventually leads to dilated heart failure, which is a common cause of heart failure in human hypertensive and valvular heart disease. We have recently reported that ROCK1 homozygous knockout mice exhibited reduced cardiac fibrosis and cardiomyocyte apoptosis, while displayed a preserved compensatory hypertrophic response to pressure overload. Here, we tested effects of ROCK1 deficiency on cardiac hypertrophy, dilation, and dysfunction by using the transgenic Gαq mice which represent a well-characterized and highly relevant genetic mouse model of pathological hypertrophy and heart failure. We have shown that ROCK1 deletion prevented left ventricular dilation and contractile dysfunction in Gαq mice under basal condition. ROCK1 deletion also partially rescued bradycardia and improved contractile response to β-adrenergic stimulation in Gαq mice. Although the development of cardiomyocyte hypertrophy was not affected, ROCK1 deletion in Gαq mice resulted in a concentric hypertrophic phenotype associated with reduced induction of hypertrophic markers. Finally, ROCK1 deletion prevented down-regulation of type V adenylyl cyclase expression, which is a critical molecular defect contributing to the impaired β-adrenergic signaling in Gαq mice. The present study establishes for the first time a role for ROCK1 in cardiac dilation and contractile dysfunction.
Abstract 3861: Over-expression of the A1-Adenosine Receptor Alters Cardiac Function by Inhibiting Production of Caveolin-3
Authors: Ellina Cheskis, Paul H Chung, Brent R DeGeorge, Elizabeth W Feldman, Hajime Funakoshi, Whitney Jackson, Jean-Francois Jasmin, Walter J Koch, Michael P Lisanti, Xin-Liang Ma, Valerie D Myers, Jianliang Song, Justin Wagner, Yajing Wang, Diana Whitaker-Menezes, Rao V Yelamarty, Jin Zhang, Joseph Y Cheung, Tung O Chan, Arthur M Feldman
Journal: Circulation (2009)

Cardiac specific constitutive over-expression of A1-adenosine receptor (A1-AR) resulted in hypertrophy, dilatation, and abnormalities in calcium handling; however the mechanisms responsible for the...
Abstract P34: Nitrite Therapy upon Resuscitation from Cardiac Arrest Reversibly Inhibits Mitochondrial Complex I Reducing ROS Burst and Improving Cardiac Function and Survival
Authors: Cameron Dezfulian, Sruti Shiva, Akshay Pendyal, Aleksey Alekseyenko, Stasia A Anderson, Mark T Gladwin
Journal: Circulation (2008)

Nitrite reversibly S-nitrosates mitochondrial electron transport chain complex I (cxI) resulting in transient inhibition and reduction of pathological ROS burst after ischemia. We hypothesized that nitrite therapy at CPR initiation could thus improve cardiac contractility and mortality. Anesthetized C57BL/6 mice underwent hyperkalemic cardiac arrest maintained for 12min at 36.5C prior to randomly receiving blinded IV nitrite or saline placebo, epinephrine, chest compressions and ventilation for up to 150 sec. ROSC was obtained in excess of 90% in both groups. Hearts were excised just prior to asystole, 5 or 60 minutes after the initiation of CPR and mitochondria isolated. Respiration was assessed by oxygen consumption after providing the cxI substrate pyruvate or the complex II (cxII) substrate succinate. CxI activity was directly assayed by NADH oxidation, peroxide generation measured by Amplex Red peroxidation and ATP production quantified by luciferin luminescence. Nitrite therapy was associated with improved hemodynamics and significantly improved LVEF and RVEF (Table 1 ) and better 22h survival (HR 2.72 [95% CI:1.1– 6.7]). Nitrite significantly reduced cxI mediated respiration 5 min post-CPR with loss of inhibition by 60min based on respiration and ATP production (Table II ). Respiration efficiency (respiratory control ratio) did not change, nor was there significant cxII inhibition. Early cxI inhibition was associated with significantly less ROS. Nitrite therapy transiently and reversibly inhibits cxI reducing reperfusion ROS-mediated injury and resulting in less myocardial dysfunction and death after cardiac arrest. Myocardial dysfunction occurs after cardiac arrest and is reduced with nitrite therapy Nitrite therapy specifically and reversibly inhibits complex I and reduces ROS generation
Abstract 12812: In Out of Hospital Cardiac Arrest Due to Ventricular Fibrillation Amplitude Spectral Area, Amsa, and Slope Predict Defibrillation in Shock Resistant Vf but Not Recurrent Vf
Authors: Madhan Shanmugasundaram, Michael J Kellum, Gordon A Ewy, Julia H Indik
Journal: Circulation (2010)

Introduction:  Patients with out of hospital cardiac arrest (OHCA) due to ventricular fibrillation (VF) may have recurrent VF during resuscitation or VF that fails to defibrillate (shock resistant). While the VF waveform, assessed by the amplitude spectral area (AMSA) and slope, can predict successful defibrillation overall, it is unknown whether AMSA and slope have a similar predictive power for recurrent VF compared to shock resistant VF. This has implications for how to optimize the timing of defibrillation and avoid unnecessary shocks based upon the type of VF, recurrent or shock resistant.   Methods:  Patients with OHCA due to witnessed VF as the initial rhythm were included in this study. AMSA and slope were measured immediately prior to each shock. For second or later shocks, VF was classified as either recurrent (if the previous shock had successfully defibrillated VF) or as shock resistant (if the preceding shock had failed to defibrillate VF).   Results:  33 subjects were analyzed who received more than one shock during resuscitation, with 135 shocks delivered for either recurrent VF or shock resistant VF. Defibrillation was more likely to be successful in recurrent VF compared to shock-resistant VF (OR =13, P   Conclusions:  In witnessed OHCA with VF as the initial rhythm, recurrent VF is likely to be successfully re-defibrillated, and there is no predictive utility in assessing AMSA and slope prior to delivery of a shock. However, when VF is shock resistant, AMSA and slope are highly predictive of an immediately successful defibrillatory shock.
Film: The Knowledge of Healing
Authors: L. Culliford
Journal: BMJ (1998)

Director Franz Reichle 89 minutes, at selected cinemas around Britain ——————— Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> It would be unwise to dismiss the ancient and comprehensive healing tradition embodied in today's system of Tibetan medicine simply because diagnosis and treatment seem strange and the beautiful texts are obscure, for the lack of controlled clinical trials, or because of the Buddhist emphasis on spirit as well as body and mind. It would be additionally foolish to ignore it … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif