LIVER FUNCTION IN HEPATITIS
Authors: C J WATSON, F W HOFFBAUER
Journal: Annals of Internal Medicine (1947)

Article1 June 1947LIVER FUNCTION IN HEPATITISC. J. WATSON, F.A.C.P., F. W. HOFFBAUERC. J. WATSON, F.A.C.P., F. W. HOFFBAUERAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-6-813 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe effective morbidity incidence of hepatitis during the war was very great, due not only to the large number of individuals affected but also to the long period of disability. Considerable evidence has been obtained that complete bed rest early in the course of the disease is likely to result in a shorter and milder illness with fewer residual abnormalities.1, 2, 3It has also been reasonably well established that to return to physical activity before adequate subsidence of the disease is to invite a relapse which may be more severe than the initial attack.1, 3One of the main...Bibliography1. WATSON CJ: Diseases of the gall bladder and bile ducts in Cecil's Textbook of Medicine, 5th Ed., 1940, W. B. Saunders Co., Philadelphia, p. 883. Google Scholar2. TURNERSNAVELYGROSSMANBACHANANFOSTER RHJREBRNSO: Some clinical studies of acute hepatitis occurring in soldiers after inoculation with yellow fever vaccine, with especial consideration of severe attacks, Ann. Int. Med., 1944, xx, 193-218. Google Scholar3. BARKERCAPPSALLEN MHRBFW: Acute infectious hepatitis in the Mediterranean theater, including acute hepatitis without jaundice, Jr. Am. Med. Assoc., 1945, cxxviii, 997-1002. CrossrefGoogle Scholar4a. WATSONHOFFBAUER CJFW: The problem of prolonged hepatitis with particular reference to the cholangiolitic type and to the development of cholangiolitic cirrhosis of the liver, Ann. Int. Med., 1946, xxv, 195-227. Google Scholar4b. HOFFBAUEREVANSWATSON FWGTCJ: Cirrhosis of the liver: With particular reference to correlation of composite liver function studies with liver biopsy, Med. Clin. N. Am., 1945, 363-389. CrossrefGoogle Scholar5. EPPINGER H: Die Leberkrankheiten. Allgemeine und spezielle Pathologie und Therapie der Leber, 1937, Julius Springer, Wien. Google Scholar6. ASCHOFF L: Die Erkrankungen der steinfreien Gallenwege. Anatomisches Referat, Verhandl. d. deutsch. Gesellsch. f. inn. Med., 1932, xliv, 261-289. Google Scholar7. NEEFESTOKESREINHOLDLUKENS JRJJGFD: Hepatitis due to the injection of homologous blood products in human volunteers, Jr. Clin. Invest., 1944, xxiii, 836-855. CrossrefGoogle Scholar8. MANCHESIEDE RW: Differential diagnosis of icterus catarrhalis and of hepatitis epidemica. I. Varieties of so-called icterus catarrhalis, München. med. Wchnschr., 1942, lxxxix, 923-930. Abstract Jr. Am. Med. Assoc., 1944, cxxvi, 733. Google Scholar9. GELLISSTOKES SSJ: The methylene blue test in infectious (epidemic) hepatitis, Jr. Am. Med. Assoc., 1945, cxxviii, 782-783. CrossrefGoogle Scholar10. BESTTAYLOR CHNB: The physiological basis of medical practice, 1939, The Williams and Wilkins Company, Baltimore, page 758. Google Scholar11. WALLACEDIAMOND GBJS: Significance of urobilinogen in the urine as a test for liver function, Arch.. Int. Med., 1925, xxxv, 698-725. CrossrefGoogle Scholar12. BUDD G: Diseases of the liver, 1846, Lea and Blanchard, Philadelphia, page 368. Google Scholar13. VAN DEN BERGH AA: Der Gallenfarbstoff im Blute, Ed. 1, 1918, Van Doesburgh, Leyden. Google Scholar14. LEPEHNE G: Qualitative studies of bilirubin in body fluids. I. A comparison of the direct diazo reaction by the photoelectric colorimeter, the three test tube method and the oxidation test in serum, Jr. Lab. and Clin. Med., 1942, xxvii, 1447-1457. Google Scholar15. FENNEL EA: Jaundice and the laboratory; photelometric bilirubin and urobilinogen determinations, Proc. Staff Meet. Clinic, Honolulu, 1942, viii, 120-126. Google Scholar16. WATSON CJ: Some newer concepts of the natural derivatives of hemoglobin, Blood, Jr. Hemat., 1946, i, 99-120. Google Scholar17. HUNTER G: On two types of bilirubin diazo-reaction in serum, with hypothesis on the nature of the bilirubin in the serum from haemolytic jaundice, Brit. Jr. Exper. Path., 1930, xi, 415-419. Google Scholar18. RICH AR: The pathogenesis of the forms of jaundice, Bull. Johns Hopkins Hosp., 1930, xlvii, 338-377. Google Scholar19. HIYEDA K: Experimentelle Studien über den Ikterus: Ein Beitrag zur Pathogenese des Stauungsikterus, Beitr. z. path. Anat. u. z. allg. Path., 1925, lxxiii, 541-565. Google Scholar20. ITOH T: Experimentelle Studien über die Pathogenese des Toluylenediamin Ikterus, Beitr. z. path. Anat. u. z. allg. Path., 1931, lxxxvi, 448-516. Google Scholar21. GONZALEZ-ODDONE MV: Bilirubin, bromsulfalein, bile acids, alkaline phosphatase and cholesterol in experimental regurgitation jaundice, Proc. Soc. Exper. Biol. and Med., 1946, lxiii, 144-147. CrossrefGoogle Scholar22. DUCCIWATSON HC: The quantitative determination of the serum bilirubin with special reference to the prompt-reacting and the chloroform-soluble types, Jr. Lab. and Clin. Med., 1945, xxx, 293-300. Google Scholar23. HAWKINSONWATSONTURNER VCJRH: A modification of Harrison's test for bilirubin in the urine, especially suited for mass and serial usage, Jr. Am. Med. Assoc., 1945, cxxix, 514-515. CrossrefGoogle Scholar24. WATSONHAWKINSON CJV: Semi-quantitative estimation of bilirubin in the urine by means of the "barium strip" modification of Harrison's test, Jr. Lab. and Clin. Med., 1946, xxxi, 914-915. Google Scholar25. WATSONSBOROVSCHWARTZ CJVS: Formation of laevorotatory stercobilin from mesobilirubinogen in human feces, Proc. Soc. Exper. Biol. and Med., 1942, xlix, 647-651. CrossrefGoogle Scholar26. WATSON CJ: The bile pigments, New England Jr. Med., 1942, ccxxvii, 665-711. CrossrefGoogle Scholar27. WATSON CJ: Studies of urobilinogen; the per diem excretion of urobilinogen in the common forms of jaundice and diseases of the liver, Arch. Int. Med., 1937, lix, 206-231. CrossrefGoogle Scholar28. OLIVAMASSIMELLO GF: Sulla ritenzione urobilinemica nelle nefropatie, Arch. p. l. Sci. Med., 1935, lix, 467. Google Scholar29. WATSON CJ: Cirrhosis of the liver: Clinical aspects with particular reference to liver function, Am. Jr. Clin. Path., 1943, xiii, 129-137. Google Scholar30. TERWEN AJ: Über ein neues Verfahren zur quantitative Urobilin Bestimmung in Harn und Stuhl, Deutsch. Arch. f. klin. Med., 1925, cxlix, 72-101. Google Scholar31. SCHWARTZSBOROVWATSON SVCJ: Studies of urobilinogen. IV. The quantitative determination of urobilinogen by means of the Evelyn photoelectric colorimeter, Am. Jr. Clin. Path., 1944, xiv, 598-604. CrossrefGoogle Scholar32a. WATSONSCHWARTZSBOROVBERTIE CJSVE: Studies of urobilinogen. V. A simple method for the quantitative recording of the Ehrlich reaction as carried out with urine and feces, Am. Jr. Clin. Path., 1944, xiv, 605-615. CrossrefGoogle Scholar32b. WATSONHAWKINSON CJV: Studies of urobilinogen. VI. Further experience with the simple quantitative Ehrlich reaction. Corrected calibration of the Evelyn colorimeter with a Pontacyl dye mixture in terms of urobilinogen, Am. Jr. Clin. Path., 1947, xvii, 108-116. CrossrefGoogle Scholar33. HALLOCKHEAD PDP: Simple laboratory test as an aid in recognizing early hepatitis, Bull. U. S. Army Med. Dept., 1946, v, 236-242. Google Scholar34. MACLAGAN NF: The thymol turbidity test as an indicator of liver dysfunction, Brit. Jr. Exper. Path., 1944, xxv, 234-241. Google Scholar35. RECANTCHARGAFFHANGER LEFM: Comparison of the cephalin-cholesterol flocculation test with the thymol turbidity test, Proc. Soc. Exper. Biol. and Med., 1945, lx, 245-247. CrossrefGoogle Scholar36. SPERRYSCHÖNHEIMER WR: A micro-method for the determination of free and total cholesterol, Jr. Biol. Chem., 1934, cvi, 745. Google Scholar37. GUTMANOLSONGUTMANFLOOD ABKBEBCA: Effect of disease of the liver and biliary tract upon the phosphatase activity of the serum, Jr. Clin. Invest, 1940, xix, 129-152. CrossrefGoogle Scholar38. JOSEPHSON B: The determination of cholic acids in blood, Biochem. Jr., 1935, xxix, 1519-1524. CrossrefGoogle Scholar39. WATSONHAWKINSON CJV: Studies of coproporphyria II. The isomer distribution and per diem excretion in hepatitis and mechanical jaundice (to be published). Google Scholar40. WATSONHOFFBAUERHOWARD CJFWR: Relation of infectious hepatitis to cirrhosis of the liver with particular reference to the cholangiolitic type. Hanot's cirrhosis; so-called hypertrophic biliary cirrhosis), Trans. Assoc. Am. Phys. (In press.) Google Scholar41. HOWARDWATSON RBCJ: Antecedent jaundice in cirrhosis of the liver, Arch. Int. Med., in press. Google Scholar42. WATSONRAPPAPORT CJEM: A comparison of the results obtained with the Hanger cephalin cholesterol flocculation test and the Maclagan thymol turbidity test in patients with liver disease, Jr. Lab. and Clin. Med., 1945, xxx, 983-991. Google Scholar43. HANGER FM: Discussion of symposium on hepatitis, Trans. Assoc. Am. Phys., 1946. (In press.) Google Scholar44. HOAGLUNDSHANK CHRE: Infectious hepatitis: A review of 200 cases, Jr. Am. Med. Assoc., 1946, cxxx, 615-621. CrossrefGoogle Scholar45. BARKERCAPPSALLEN MHRBFW: Chronic hepatitis in the Mediterranean theater, a new clinical syndrome, Jr. Am. Med. Assoc., 1945, cxxix, 653-659. CrossrefGoogle Scholar46. NEEFE J: Discussion of liver symposium, Trans. Assoc. Am. Phys., 1946. (In press.) Google Scholar47. HOAGLUND CL: Discussion of liver symposium, Trans. Assoc. Am. Phys., 1946. (In press.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Clinical lecture presented in part at the meeting of the American College of Physicians, Philadelphia, May 15, 1946. Aided by grants from the Hormel Research Foundation and the Medical Research Fund of the Graduate School of the University of Minnesota.From the Department of Medicine, University of Minnesota Hospital, Minneapolis, Minnesota.†Civilian Consultant in Hepatic Diseases to the Secretary of War. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Quest for Uniformity in Mediation Confidentiality: Foolish Consistency or Crucial Predictability?Accuracy of urine urobilinogen and bilirubin assays in predicting liver function test abnormalitiesVirushepatitisVirushepatitisSerum Bile Pigment Fractions During the Course Of JaundicePRIMARY INTRAHEPatIC CHOLESTASIS IN EARLY INFANCYSpätfolgen der Virus-HepatitisHEPATITIS AND CIRRHOSIS IN INFANCYSerum alkaline phosphatase activity in hepatitis of infectious mononucleosisINFECTIVE HEPATITIS: ITS INCIDENCE AND ITS SEQUELÆEvaluation of hepatic dysfunctionTHE SYNTHESIS OF BILIRUBIN GLUCURONIDE BY TISSUE HOMOGENATESTHE IMPORTANCE OF THE FRACTIONAL SERUM BILIRUBIN DETERMINATION IN CLINICAL MEDICINE*C. J. WATSON, M.D., Ph.D., F.A.C.P.Cholangiolitic HepatitisEXCRETORY FUNCTION OF THE LIVER A RE-ASSESSMENTAn Evaluation of Factors Influencing the Discriminative Effectiveness of a Group of Liver Function TestsLebererkrankungen im KindesalterThe serum lipoproteins in infectious mononucleosisDIFFERENTIAL DIAGNOSIS OF "REGURGITATION" JAUNDICE: THE RÔLE OF NEEDLE LIVER BIOPSY*E. R. MOVITT, M.D., F.A.C.P.Significance of Hepatomegaly in Infants and ChildrenDie Krankheiten der Leber und der GallenwegeThe Differentiation of Parenchymal Liver Disease and Mechanical Biliary ObstructionThe Diagnosis of HepatitisSickle cell anemiaSerum cholesterol and cholesterol esters in viral hepatitisFurther Observations on the Value of Plasma Vitamin A Determinations in the Differential Diagnosis of JaundiceHepatic dysfunction in candidates for abdominal surgery, especially in patients with cancerPrüfung der LeberfunktionCorrelation of liver function and liver structureLiver Function in Newborn Infants: With Special Reference to Excretion of BromsulphaleinLiver Function in Chronic Alcoholic PatientsRed Blood Cell Diameter in Acute HepatitisThe Validity of Laboratory Evidence in the Diagnosis of the Sequelae of Acute HepatitisInfectious HepatitisJaundice and hepatitis: A laboratory review 1 June 1947Volume 26, Issue 6Page: 813-842KeywordsDisabilitiesExerciseGraduate medical educationHepatitisHospital medicineLiverMorbidityResearch funding ePublished: 1 December 2008 Issue Published: 1 June 1947 Copyright & PermissionsCopyright, 1947, by The American College of PhysiciansPDF downloadLoading ...