BENIGN FAMILIAL ICTERUS: A REPORT OF THREE CASES
Authors: S R FOX
Journal: Annals of Internal Medicine (1959)

Article1 January 1959BENIGN FAMILIAL ICTERUS: A REPORT OF THREE CASESS. ROSS FOX JR., M.D.S. ROSS FOX JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-1-115 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBenign familial icterus is a clinical entity, not infrequently encountered, that is often confused with hemolytic disease, biliary tract disease, and disease of the liver. For this reason it deserves discussion. The purpose of this paper is to substantiate further the observation that the disorder tends to be hereditary. Three patients, a father and his two sons, are discussed.CASE REPORTS (Laboratory Results Table 1)Case 1. A 22 year old white Coast Guardsman was admitted on July 2, 1956, complaining of jaundice of two and one-half years' duration. Scleral icterus was first noted by the patient's mother after he...Bibliography1. GilbertLerebouletHerscher ABM: Les trois cholémies congénitales, Bull. et mém. Soc. méd. d. hôp. de Paris 24: 1203, 1907. Google Scholar2. Hijmans van den Bergh AA: Die Gallenfarbstoffe im Blute, 1918, S. C. van Doesburgh, Leiden. Google Scholar3. Meulengracht E: Icterus intermittens juvenilis, Klin. Wchnschr. 18: 118, 1939. CrossrefGoogle Scholar4. Bergmann vG: Zur funtionellen Pathologie der Leber, insbesondere der Alkohol-Atiologie der Cirrhose, Klin. Wchnschr. 6: 776, 1927. CrossrefGoogle Scholar5. RosenthalComfortSnell HMMWAM: Slight and latent jaundice, J. A. M. A. 104: 374, 1935. CrossrefGoogle Scholar6. CriglerNajjar JFVA: Congenital familial nonhemolytic jaundice with kernicterus, Pediatrics 10: 169, 1952. MedlineGoogle Scholar7. DubinJohnson INFB: Excessive lipochrome pigment in the liver cells in constitutional hyperbilirubinemia, Am. J. Path. 29: 585, 1953. Google Scholar8. SprinzNelson HRS: Persistent nonhemolytic hyperbilirubinemia, Ann. Int. Med. 41: 952, 1954. LinkGoogle Scholar9. ReichmanDavis SWD: The recognition and differential features of indirect reacting hyperbilirubinemia, Ann. Int Med. 46: 523, 1957. LinkGoogle Scholar10. DameshekSinger WC: Familial nonhemolytic jaundice, Arch. Int. Med. 67: 259, 1941. CrossrefGoogle Scholar11. ChildsNajjar BVA: Familial nonhemolytic jaundice with kernicterus—a report of two cases without neurological damage, Pediatrics 18: 369, 1956. MedlineGoogle Scholar12. Schmid R: Bilirubin glucuronide, the direct-reacting bilirubin in serum, bile, and urine, Clin. Chem. 2: 245, 1956. Google Scholar13. SchmidHammakerAxelrod RLJ: The enzymatic formation of bilirubin glucuronide, Arch. Biochem. and Biophys. 70: 285, 1957. CrossrefMedlineGoogle Scholar14. ComfortHoyne MWRM: Constitutional hepatic dysfunction, Gastroenterology 3: 155, 1944. Google Scholar15. Comfort MW: Constitutional hepatic dysfunction, M. Clin. North America 29: 982, 1945. CrossrefGoogle Scholar16. LatheWalker GHM: An enzyme defect in neonatal jaundice and in Gunn's strain of jaundiced rats, Biochem. J. 67: 9P, 1957. Google Scholar17. MalloyLowenstein HTL: Hereditary jaundice in the rat, Canad. M. A. J. 42: 122, 1940. MedlineGoogle Scholar18. RotorManahanFlorentin ALA: Familial nonhemolytic jaundice with direct van den Bergh reaction, Acta med. Philippina 5: 37, 1948. Google Scholar19. RosenthalHardyZimmerman IMNHJ: Congenital nonhemolytic jaundice with disease of the central nervous system, Pediatrics 18: 378, 1956. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: S. ROSS FOXJR., M.D.Affiliations: Seattle, Washington*Received for publication March 24, 1958.From the U. S. Public Health Service Hospital, Seattle, Washington.Requests for reprints should be addressed to S. Ross Fox, Jr., M.D., Senior Assistant Surgeon, United States Public Health Service, U. S. Public Health Service Hospital, Seattle, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedical genetics 1959 1 January 1959Volume 50, Issue 1 Page: 115-121 Keywords Alcohols Attention Biliary system Emotions Gastrointestinal infections Heme Ingestion Liver diseases Medical services ePublished: 1 December 2008 Issue Published: 1 January 1959 PDF downloadLoading ...