tbuckley/cabot-search huggingface dataset:
Leptomeningeal collaterals regulate reperfusion in ischemic stroke and rescue the brain from futile recanalization
Authors: Nadine Felizitas Binder, Mohamad El Amki, Chaim Glück, William Middleham, Anna Maria Reuss, Adrien Bertolo, Patrick Thurner, Thomas Deffieux, Chryso Lambride, Robert Epp, Hannah-Lea Handelsmann, Philipp Baumgartner, Cyrille Orset, Philipp Bethge, Zsolt Kulcsar, Adriano Aguzzi, Mickael Tanter, Franca Schmid, Denis Vivien, Matthias Tasso Wyss, Andreas Luft, Michael Weller, Bruno Weber, Susanne Wegener
Journal: Neuron (2024)

Recanalization is the mainstay of ischemic stroke treatment. However, even with timely clot removal, many stroke patients recover poorly. Leptomeningeal collaterals (LMCs) are pial anastomotic vessels with yet-unknown functions. We applied laser speckle imaging, ultrafast ultrasound, and two-photon microscopy in a thrombin-based mouse model of stroke and fibrinolytic treatment to show that LMCs maintain cerebral autoregulation and allow for gradual reperfusion, resulting in small infarcts. In mice with poor LMCs, distal arterial segments collapse, and deleterious hyperemia causes hemorrhage and mortality after recanalization. In silico analyses confirm the relevance of LMCs for preserving perfusion in the ischemic region. Accordingly, in stroke patients with poor collaterals undergoing thrombectomy, rapid reperfusion resulted in hemorrhagic transformation and unfavorable recovery. Thus, we identify LMCs as key components regulating reperfusion and preventing futile recanalization after stroke. Future therapeutic interventions should aim to enhance collateral function, allowing for beneficial reperfusion after stroke.
Extreme Heat and Preterm Birth Risk—Methodologic Considerations and Policy Implications
Authors: Heather H. Burris, Allan C. Just
Journal: JAMA Pediatrics (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Single‐cell transcriptomics reveal the remodeling landscape of bladder in patients with obstruction‐induced detrusor underactivity
Authors: Jiawei Chen, Liao Peng, Guo Chen, Yuanzhuo Chen, Xiao Zeng, Jie Zhang, Chi Zhang, Hong Shen, Banghua Liao, Deyi Luo
Journal: MedComm (2024)

Detrusor underactivity (DUA) is a common and thorny problem in urology, which severely impairs patients' bladder function and quality of life. However, its underlying pathophysiological mechanism remains unclear. Hence, we sequenced 69,973 cells from five controls and nine patients with bladder dysfunction using single-cell RNA sequencing. Twelve distinct cell types were identified and they showed high cellular and functional heterogeneity among each group. Among them, fibroblasts, macrophages, and epithelial cells had the most intercellular communications. Their aberrant gene expressions and altered intercellular interactions were mainly involved in extracellular matrix organization, inflammation/immune regulation, and cellular injury. Further re-cluster analysis revealed an accumulation of the RBFOX1
Rapid and sensitive detection of genome contamination at scale with FCS-GX
Authors: Alexander Astashyn, Eric S. Tvedte, Deacon Sweeney, Victor Sapojnikov, Nathan Bouk, Victor Joukov, Eyal Mozes, Pooja K. Strope, Pape M. Sylla, Lukas Wagner, Shelby L. Bidwell, Larissa C. Brown, Karen Clark, Emily W. Davis, Brian Smith-White, Wratko Hlavina, Kim D. Pruitt, Valerie A. Schneider, Terence D. Murphy
Journal: Genome biology (2024)

Assembled genome sequences are being generated at an exponential rate. Here we present FCS-GX, part of NCBI's Foreign Contamination Screen (FCS) tool suite, optimized to identify and remove contaminant sequences in new genomes. FCS-GX screens most genomes in 0.1-10 min. Testing FCS-GX on artificially fragmented genomes demonstrates high sensitivity and specificity for diverse contaminant species. We used FCS-GX to screen 1.6 million GenBank assemblies and identified 36.8 Gbp of contamination, comprising 0.16% of total bases, with half from 161 assemblies. We updated assemblies in NCBI RefSeq to reduce detected contamination to 0.01% of bases. FCS-GX is available at https://github.com/ncbi/fcs/ or https://doi.org/10.5281/zenodo.10651084 .
Deucravacitinib: is there still a place or a need for a new oral agent?
Authors: Francesca Sampogna, Stefano Piaserico
Journal: British Journal of Dermatology (2024)

Journal Article Deucravacitinib: is there still a place or a need for a new oral agent? Get access Francesca Sampogna, Francesca Sampogna Conceptualization, Writing - original draft, Writing - review & editing Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome Correspondence: Francesca Sampogna. Email: fg.sampogna@gmail.com Search for other works by this author on: Oxford Academic Google Scholar Stefano Piaserico Stefano Piaserico Conceptualization, Writing - original draft, Writing - review & editing Dermatology Unit, Department of Medicine, University of Padua, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 190, Issue 5, May 2024, Pages 610–611, https://doi.org/10.1093/bjd/ljae087 Published: 26 February 2024 Article history Accepted: 18 January 2024 Received: 15 February 2024 Revision received: 20 February 2024 Published: 26 February 2024 Corrected and typeset: 21 March 2024
Postprocedural Anticoagulation After Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction: A Multicenter, Randomized, Double-Blind Trial
Authors: Yan Yan, Jincheng Guo, Xiao Wang, Guozhong Wang, Zeyuan Fan, Delu Yin, Zhifang Wang, Fuchun Zhang, Changming Tian, Wei Gong, Jiamin Liu, Jiapeng Lu, Yongjun Li, Changsheng Ma, Eric Vicaut, Gilles Montalescot, Shaoping Nie
Journal: Circulation (2024)

BACKGROUND: Postprocedural anticoagulation (PPA) is frequently administered after primary percutaneous coronary intervention in ST-segment–elevation myocardial infarction, although no conclusive data support this practice. METHODS: The RIGHT trial (Comparison of Anticoagulation Prolongation vs no Anticoagulation in STEMI Patients After Primary PCI) was an investigator-initiated, multicenter, randomized, double-blind, placebo-controlled, superiority trial conducted at 53 centers in China. Patients with ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention were randomly assigned by center to receive low-dose PPA or matching placebo for at least 48 hours. Before trial initiation, each center selected 1 of 3 PPA regimens (40 mg of enoxaparin once daily subcutaneously; 10 U·kg·h of unfractionated heparin intravenously, adjusted to maintain activated clotting time between 150 and 220 seconds; or 0.2 mg·kg·h of bivalirudin intravenously). The primary efficacy objective was to demonstrate superiority of PPA to reduce the primary efficacy end point of all-cause death, nonfatal myocardial infarction, nonfatal stroke, stent thrombosis (definite), or urgent revascularization (any vessel) within 30 days. The key secondary objective was to evaluate the effect of each specific anticoagulation regimen (enoxaparin, unfractionated heparin, or bivalirudin) on the primary efficacy end point. The primary safety end point was Bleeding Academic Research Consortium 3 to 5 bleeding at 30 days. RESULTS: Between January 10, 2019, and September 18, 2021, a total of 2989 patients were randomized. The primary efficacy end point occurred in 37 patients (2.5%) in both the PPA and placebo groups (hazard ratio, 1.00 [95% CI, 0.63 to 1.57]). The incidence of Bleeding Academic Research Consortium 3 to 5 bleeding did not differ between the PPA and placebo groups (8 [0.5%] vs 11 [0.7%] patients; hazard ratio, 0.74 [95% CI, 0.30 to 1.83]). CONCLUSIONS: Routine PPA after primary percutaneous coronary intervention was safe but did not reduce 30-day ischemic events. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03664180.
Dopamine and serotonin in human substantia nigra track social context and value signals during economic exchange
Authors: Seth R. Batten, Dan Bang, Brian H. Kopell, Arianna N. Davis, Matthew Heflin, Qixiu Fu, Ofer Perl, Kimia Ziafat, Alice Hashemi, Ignacio Saez, Leonardo S. Barbosa, Thomas Twomey, Terry Lohrenz, Jason P. White, Peter Dayan, Alexander W. Charney, Martijn Figee, Helen S. Mayberg, Kenneth T. Kishida, Xiaosi Gu, P. Read Montague
Journal: Nature Human Behaviour (2024)

Dopamine and serotonin are hypothesized to guide social behaviours. In humans, however, we have not yet been able to study neuromodulator dynamics as social interaction unfolds. Here, we obtained subsecond estimates of dopamine and serotonin from human substantia nigra pars reticulata during the ultimatum game. Participants, who were patients with Parkinson's disease undergoing awake brain surgery, had to accept or reject monetary offers of varying fairness from human and computer players. They rejected more offers in the human than the computer condition, an effect of social context associated with higher overall levels of dopamine but not serotonin. Regardless of the social context, relative changes in dopamine tracked trial-by-trial changes in offer value-akin to reward prediction errors-whereas serotonin tracked the current offer value. These results show that dopamine and serotonin fluctuations in one of the basal ganglia's main output structures reflect distinct social context and value signals.
Response by Van de Werf et al to Letter Regarding Article, “STREAM-2: Half-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Segment–Elevation Myocardial Infarction: A Randomized, Open-Label Trial”
Authors: Frans Van de Werf, Peter Sinnaeve, Robert C. Welsh, Paul W. Armstrong
Journal: Circulation (2024)
Role of arrhythmic phenotype in prognostic stratification and management of dilated cardiomyopathy
Authors: Martina Setti, Marco Merlo, Marta Gigli, Laura Munaretto, Alessia Paldino, Davide Stolfo, Carola Pio Loco, Kristen Medo, Caterina Gregorio, Antonio De Luca, Sharon Graw, Matteo Castrichini, Antonio Cannatà, Flavio Luciano Ribichini, Matteo Dal Ferro, Matthew Taylor, Gianfranco Sinagra, Luisa Mestroni
Journal: European Journal of Heart Failure (2024)
Erratum to: Sustained response off‐treatment in eltrombopag‐treated adult patients with ITP who are refractory or relapsed after first‐line steroids: Primary, final, and ad‐hoc analyses of the Phase II TAPER trial
Journal: American Journal of Hematology (2024)

Sustained response off-treatment in eltrombopag-treated adult patients with ITP who are refractory or relapsed
<i>CALR</i>‐mutated patients with low allele burden represent a specific subtype of essential thrombocythemia: A study on behalf of FIM and GBMHM
Authors: Laura Aubin, Rúben Vilas Boas, Rafael Daltro De Oliveira, Valoris Le Brun, Marion Divoux, Jérôme Rey, Olivier Mansier, Jean‐Christophe Ianotto, Cédric Pastoret, Anne Desmares, Anne Murati, Véronique de Mas, Suzanne Tavitian, François Girodon, Juliette Soret Dulphy, Nabih Maslah, Valérie Goncalves Monteiro, Françoise Boyer, Corentin Orvain, Dana Ranta, Émilie Cayssials, Lenaig Le Clech, Christophe Nicol, Camille Rottier, Teresa Botin Lopez, Brice Castel, Patrick Rispal, Guillaume Beziat, Charles Bescond, Kamel Laribi, Lina Benajiba, Valérie Ugo, Eric Lippert, Laurane Cottin, Damien Luque Paz
Journal: American Journal of Hematology (2024)

A low allele burden (i.e., <20%) of the CALR driver mutation is found in 10.8% of CALR-mutated MPNs, mostly in essential thrombocythemia, and correlates with a milder phenotype and a more indolent evolution compared to patients with an allele burden ≥20%.
Impact of air pollutants and meteorological factors on allergic rhinitis outpatient visits in Shanghai, China
Authors: Sun Na, Hao Yanan, Tian Lufang, Sun Zhenfeng, Tang Wei, Huang Yu, Gong Jingrong, Huang Wei, An Kangning, Kan Haidong, Duan Yusen, Yu Shaoqing, Zhang Ruxin
Journal: Allergy (2024)

The data that supports the findings of this study are available in the supplementary material of this article. Appendix S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Interrupting an IFN-γ-dependent feedback loop in the syndrome of pyogenic arthritis with pyoderma gangrenosum and acne
Authors: Wonyong Lee, Deborah L Stone, Patrycja Hoffmann, Sofia Rosenzweig, Wanxia Li Tsai, Massimo Gadina, Tina Romeo, Chyi-Chia Richard Lee, Davide Randazzo, Pallavi Pimpale Chavan, Kalpana Manthiram, Scott Canna, Yong Hwan Park, Amanda K Ombrello, Ivona Aksentijevich, Daniel L Kastner, Jae Jin Chae
Journal: Annals of the Rheumatic Diseases (2024)

To study the molecular pathogenesis of PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome, a debilitating hereditary autoinflammatory disease caused by dominant mutation in
Leveraging generative AI to prioritize drug repurposing candidates for Alzheimer’s disease with real-world clinical validation
Authors: Chao Yan, Monika E. Grabowska, Alyson L. Dickson, Bingshan Li, Zhexing Wen, Dan M. Roden, C. Michael Stein, Peter J. Embí, Josh F. Peterson, QiPing Feng, Bradley A. Malin, Wei-Qi Wei
Journal: npj Digital Medicine (2024)

Drug repurposing represents an attractive alternative to the costly and time-consuming process of new drug development, particularly for serious, widespread conditions with limited effective treatments, such as Alzheimer's disease (AD). Emerging generative artificial intelligence (GAI) technologies like ChatGPT offer the promise of expediting the review and summary of scientific knowledge. To examine the feasibility of using GAI for identifying drug repurposing candidates, we iteratively tasked ChatGPT with proposing the twenty most promising drugs for repurposing in AD, and tested the top ten for risk of incident AD in exposed and unexposed individuals over age 65 in two large clinical datasets: (1) Vanderbilt University Medical Center and (2) the All of Us Research Program. Among the candidates suggested by ChatGPT, metformin, simvastatin, and losartan were associated with lower AD risk in meta-analysis. These findings suggest GAI technologies can assimilate scientific insights from an extensive Internet-based search space, helping to prioritize drug repurposing candidates and facilitate the treatment of diseases.
Pancreatic Neuroendocrine Microtumors (WHO 2022) Are Not Always Low-Grade Neoplasms: A Case with a Highly Increased Proliferation Rate
Authors: Aziz Chouchane, Philipp Kirchner, Ilaria Marinoni, Eva Sticová, Tomáš Jirásek, Aurel Perren
Journal: Endocrine Pathology (2024)

Traditionally considered non-functional low proliferative benign neuroendocrine proliferations measuring less than 5 mm, pancreatic (neuro)endocrine microadenomas are now classified as pancreatic neuroendocrine microtumors in the 2022 WHO classification of endocrine and neuroendocrine tumors. This case report discussed the features of an incidentally identified 4.7-mm glucagon-expressing pancreatic neuroendocrine microtumor with MEN1 mutation only, chromosomally stable and an epigenetic alpha-like phenotype. The tumor was associated with an unexplained increased proliferation rate in Ki-67 of 15%. There was no associated DAXX/ATRX deficiency. The presented case challenges the conventional thought of a low proliferative disease of the so-called "pancreatic neuroendocrine microadenomas" and provides additional support to the 2022 WHO classification that also requires grading of these neoplasms. Despite exhibiting molecular features of less aggressive behavior, the case also underscores the biological complexity of pancreatic neuroendocrine microtumors. By recognizing the heterogenous spectrum of neuroendocrine neoplasms, the current case also contributes to ongoing discussions on how to optimize the clinical management of such tumors.
South Korea: Striking junior doctors are threatened with arrest and suspension
Authors: Owen Dyer
Journal: BMJ (2024)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following South Korea: Striking junior doctors are threatened with arrest and suspension Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Origin of Transthyretin in Cerebral Amyloid Angiopathy
Authors: Toshiya Nomura, Yohei Misumi, Masayoshi Tasaki, Konen Obayashi, Taro Yamashita, Yukio Ando, Mitsuharu Ueda
Journal: JAMA Neurology (2024)

This case series evaluates the correlation between transthyretin and cerebral amyloid angiopathy progression in individuals with hereditary transthyretin amyloidosis.
Functional Outcomes in Conservatively vs Surgically Treated Cerebellar Infarcts
Authors: Sae-Yeon Won, Silvia Hernández-Durán, Bedjan Behmanesh, Joshua D. Bernstock, Marcus Czabanka, Nazife Dinc, Daniel Dubinski, Thomas M. Freiman, Albrecht Günther, Kara Hellmuth, Eva Herrmann, Juergen Konczalla, Ilko Maier, Ruzanna Melkonian, Dorothee Mielke, Paul Naser, Veit Rohde, Christian Senft, Alexander Storch, Andreas Unterberg, Johannes Walter, Uwe Walter, Matthias Wittstock, Jan Hendrik Schaefer, Florian Gessler
Journal: JAMA Neurology (2024)

According to the current American Heart Association/American Stroke Association guidelines, decompressive surgery is indicated in patients with cerebellar infarcts that demonstrate severe cerebellar swelling. However, there is no universal definition of swelling and/or infarct volume(s) available to support a decision for surgery.
Misinformation and the Vaccine Adverse Event Reporting System
Authors: Kathleen Hall Jamieson, Kevin B. Johnson, Anne R. Cappola
Journal: JAMA (2024)

This Viewpoint posits that to improve public understanding of the system, the Vaccine Adverse Event Reporting System (VAERS) could use a more accurate name, well-defined guidance about the reporting system’s nature and use, and comprehensible information about an event’s verification status.
Cost of Care for Newborns With Neonatal Abstinence Syndrome in a State Medicaid Program
Authors: Caroline Jenkins, Matthew Hudnall, Courtney Hanson, Dwight Lewis, Jason M. Parton
Journal: JAMA Network Open (2024)

Importance Neonatal abstinence syndrome (NAS) is a medical condition among neonates experiencing substance withdrawal due to the mother’s substance use during pregnancy. While previous studies suggest that the overall incidence and annual costs of NAS are increasing, to date, the long-term costs have yet to be demonstrated in Medicaid populations. Objective To examine the demographic differences and long-term costs of care for neonates diagnosed with vs not diagnosed with NAS. Design, Setting, and Participants This cohort study used claims data from the Alabama Medicaid Agency for neonates born to Medicaid-eligible mothers between January 1, 2010, and December 31, 2020. Data were analyzed in June 2022. Exposure A diagnosis of NAS within 30 days of birth. Main Outcomes and Measures Rate of NAS by demographic and birth characteristics, long-term costs attributable to NAS status and demographic and birth characteristics, and distribution of this expenditure over the enrollment period. Results A total of 346 259 neonates with Medicaid eligibility were born during the study period (mean [SD] gestational age, 38.4 [2.2] weeks; 50.5%, male), 4027 (1.2%) of whom had an NAS diagnosis within 30 days of birth. A larger percentage of neonates with an NAS diagnosis were male (52.7%) than in the group without NAS (50.5%). Neonates with NAS also weighed less at birth (mean difference, −212.0 g; 95% CI, −231.1 to −192.8 g) and had older mothers (mean difference, 3.4 years; 95% CI, 2.6-4.2 years). An NAS diagnosis had an estimated additional cost of $17 921 (95% CI, $14 830-$21 012) over the enrollment period, and this cost was not evenly distributed over that period. Conclusions and Relevance In this cohort study of neonates born into the Alabama Medicaid population, those with an NAS diagnosis had a different demographic profile and a higher cost to state Medicaid agencies than those without NAS. These findings warrant further effort to reduce the occurrence of NAS.
Patient Sex in Prescribing CGRP Receptor Antagonists for Migraine—Reply
Authors: Frank Porreca, David W. Dodick
Journal: JAMA Neurology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal