tbuckley/cabot-search huggingface dataset:
Influence of endoxifen on mammographic density—results from the KARISMA trial
Authors: Mattias Hammarström, Marike Gabrielson, Jenny Bergqvist, Cecilia Lundholm, Alessio Crippa, Magnus Bäcklund, Yvonne Wengström, Signe Borgquist, Erik Eliasson, Mikael Eriksson, José Tapia, Kamila Czene, Per Hall
Journal: JNCI Journal of the National Cancer Institute (2024)

Abstract Background Monitoring metabolites of tamoxifen, such as endoxifen, has been suggested as a strategy to ascertain therapeutic effect of tamoxifen therapy, but clinical guidelines are missing. Herein, we aim to investigate the outcome of endoxifen concentrations of low-dose tamoxifen, using change in mammographic breast density as a proxy for therapy response. Methods In the randomized KARISMA-Tam (Karolinska Mammography project for risk prediction of breast cancer -Intervention Study with Tamoxifen) trial, including 5 doses of tamoxifen, measurements of plasma endoxifen concentrations, determination of CYP2D6 metabolizer status, and mammographic breast density change over the trial period were carried out. Association between endoxifen concentrations and relative mammographic breast density change after 6 months treatment was analyzed using linear regression in a spline model. Results A total of 824 women (335 premenopausal, 489 postmenopausal) were included. In analyses of premenopausal women, a spline model described a mammographic breast density decrease, equivalent to the mean (−18.5%) seen in women exposed to 20 mg tamoxifen, at endoxifen concentrations of 2-3 ng/mL. The mammographic breast density decrease reached a nadir at endoxifen levels of 3 ng/mL and did not decrease further at higher endoxifen concentrations. Most intermediate and normal tamoxifen metabolizers (about 90% of all participants) reached an endoxifen concentration of more than 2 ng/mL at tamoxifen doses of 5 and 10 mg. No mammographic breast density decrease was seen in the postmenopausal group. Conclusions We have identified a possible window of effect on mammographic breast density at endoxifen concentrations of 2-3 ng/mL in premenopausal women, which corresponds to the doses of 5 and 10 mg tamoxifen. Because mammographic breast density change was used as a surrogate marker for therapy response, results should be confirmed using clinically established outcomes measures.
A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses
Authors: Yexin Yang, Rebecca S. Treger, Juan Hernandez-Bird, Peiwen Lu, Tianyang Mao, Akiko Iwasaki
Journal: Science Immunology (2024)

Endogenous retroviruses (ERVs), comprising a substantial portion of the vertebrate genome, are remnants of ancient genetic invaders. ERVs with near-intact coding potential reactivate in B cell-deficient mice. To study how B cells contribute to host anti-ERV immunity, we used an antigen-baiting strategy to enrich B cells reactive to ERV surface antigens. We identified ERV-reactive B-1 cells expressing germline-encoded natural IgM antibodies in naïve mice, the level of which further increases upon innate immune sensor stimulation. B cell receptor repertoire profiling of ERV-reactive B-1 cells revealed increased usage of the
Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction
Authors: Shengxiang Sun, Miki Hodel, Xiang Wang, Javier De Vicente, Talin Haritunians, Anketse Debebe, Chen-Ting Hung, Changqing Ma, Atika Malique, Hoang N. Nguyen, Maayan Agam, Michael T. Maloney, Marisa S. Goo, Jillian H. Kluss, Richa Mishra, Jennifer Frein, Amanda Foster, Samuel Ballentine, Uday Pandey, Justin Kern, Shaohong Yang, Emebet Mengesha, Iyshwarya Balasubramanian, Annie Arguello, Anthony A. Estrada, Nan Gao, Inga Peter, Dermot P. B. McGovern, Anastasia G. Henry, Thaddeus S. Stappenbeck, Ta-Chiang Liu
Journal: Science Immunology (2024)

polymorphisms (G2019S/N2081D) that increase susceptibility to Parkinson's disease and Crohn's disease (CD) lead to LRRK2 kinase hyperactivity and suppress autophagy. This connection suggests that LRRK2 kinase inhibition, a therapeutic strategy being explored for Parkinson's disease, may also benefit patients with CD. Paneth cell homeostasis is tightly regulated by autophagy, and their dysfunction is a precursor to gut inflammation in CD. Here, we found that patients with CD and mice carrying hyperactive
Serum lipidomic signatures in patients with varying histological severity of metabolic-dysfunction associated steatotic liver disease
Authors: Sneha Muralidharan, Jonathan W J Lee, Yee Siang Lim, Mark Muthiah, Eunice Tan, Deniz Demicioglu, Asim Shabbir, Wai Mun Loo, Chieh Sian Koo, Yin Mei Lee, Gwyneth Soon, Aileen Wee, Nur Halisah, Sakinah Abbas, Shanshan Ji, Alexander Triebl, Bo Burla, Hiromi W L Koh, Yun Shen Chan, Mei Chin Lee, Huck Hui Ng, Markus R Wenk, Federico Torta, Yock Young Dan
Journal: Metabolism (2024)
On-demand reprogramming of immunosuppressive microenvironment in tumor tissue via multi-regulation of carcinogenic microRNAs and RNAs dependent photothermal-immunotherapy using engineered gold nanoparticles for malignant tumor treatment
Authors: Li Chen, Wenjun Tang, Jie Liu, Man Zhu, Wenyun Mu, Xiaoyu Tang, Tao Liu, Zeren Zhu, Lin Weng, Yumeng Cheng, Yanmin Zhang, Xin Chen
Journal: Biomaterials (2024)
Detection of circulating type 3 vaccine-derived polioviruses in French Guiana, May to August 2024
Authors: Stéphanie Raffestin, Ambre Tinard, Antoine Enfissi, Marie-Line Joffret, Timothée Lichtenstein, Sourakhata Tirera, Laura Zanetti, Marie Barrau, Francky Mubenga, Adrien Ortelli, Christophe N Peyrefitte, Anne Lavergne, Dominique Rousset, Maël Bessaud
Journal: Eurosurveillance (2024)

Circulating type 3 vaccine-derived polioviruses (cVDPV3s) were detected in three wastewater samples collected in French Guiana from May through August 2024. As the oral polio vaccine is not used in French Guiana, this event involved an import either of cVDPV3s themselves or of a vaccine strain from which the cVDPV3s emerged in French Guiana. This highlights the importance of environmental surveillance for the detection of silent poliovirus circulation. Eliminating any pockets of cVDPVs is crucial for the polio eradication programme.
Priorities in tackling noncommunicable diseases among the population aged 60 years and older in China, 1990-2021: A population-based study
Authors: Yi Dai, Di Teng, Chengshuo Zhang, Haoyu Wang, Yaxin Lai, Shuangning Ding, Yang Han, Lei Dou, Shize Yang, Yue Ma, Bingyang Liu, Ziyu Gao, Liang He, Xu Han, Guofeng Zhang, Qiaobei Li, Qinghong Zeng, Hangjia Liu, Haoran Zhou, Siyu Wang, Yanyan Gao, Jiahui Guo, Xiaochen Xie, Jing Zhang, Yongze Li
Journal: Ageing Research Reviews (2024)
Describing functional diversity of communities from environmental DNA
Authors: Isabel Cantera, Simone Giachello, Tamara Münkemüller, Marco Caccianiga, Mauro Gobbi, Gianalberto Losapio, Silvio Marta, Barbara Valle, Krzysztof Zawierucha, Wilfried Thuiller, Gentile Francesco Ficetola
Journal: Trends in Ecology & Evolution (2024)
Ehealth interactive intervention in promoting safer sex among men who have sex with men
Authors: Edmond Pui Hang Choi, Chanchan Wu, Kitty Wai Ying Choi, Pui Hing Chau, Eric Yuk Fai Wan, William Chi Wai Wong, Janet Yuen Ha Wong, Daniel Yee Tak Fong, Eric Pui Fung Chow
Journal: npj Digital Medicine (2024)

Men who have sex with men (MSM) who use dating applications (apps) have higher rates of engaging in condomless anal sex than those who do not. Therefore, we conducted a two-arm randomized controlled trial to evaluate the effectiveness of an interactive web-based intervention in promoting safer sex among this population. The intervention was guided by the Theory of Planned Behavior and co-designed by researchers, healthcare providers, and MSM participants. The primary outcome was the frequency of condomless anal sex in past three months. Secondary outcomes included five other behavioral outcomes and two psychological outcomes. This trial was registered on ISRCTN (ISRCTN16681863) on 2020/04/28. A total of 480 MSM were enrolled and randomly assigned to the intervention or control group. Our findings indicate that the intervention significantly reduced condomless anal sex behaviors by enhancing self-efficacy and attitudes toward condom use among MSM dating app users, with the effects sustained at both three and six months.
Thio-ProTide strategy: a novel H2S donor–drug conjugate (DDC) alleviates hepatic injury via innate lysosomal targeting
Authors: Haowen Jin, Jie Ma, Bixin Xu, Sitao Xu, Tianyu Hu, Xin Jin, Jiankun Wang, Guangji Wang, Le Zhen
Journal: Acta Pharmaceutica Sinica B (2024)

Hydrogen sulfide (H2S) is a gas signaling molecule with versatile bioactivities; however, its exploitation for disease treatment appears challenging. This study describes the design and characterization of a novel type of H2S donor-drug conjugate (DDC) based on the thio-ProTide scaffold, an evolution of the ProTide strategy successfully used in drug discovery. The new H2S DDCs achieved hepatic co-delivery of H2S and an anti-fibrotic drug candidate named hydronidone, which synergistically attenuated liver injury and resulted in more sufficient intracellular drug exposure. The potent hepatoprotective effects were also attributed to the H2S-mediated multipronged intervention in lipid peroxidation both at the whole cellular and lysosomal levels. Lysosomal H2S accumulation and H2S DDC activation were facilitated by the hydrolysis through the specific lysosomal hydrolase, representing a distinct mechanism for lysosomal targeting independent of the classical basic moieties. These findings provided a novel pattern for the design of optimally therapeutic H2S DDC and organelle-targeting functional molecules.
Functional outcome after infectious encephalitis: a longitudinal multicenter prospective cohort study.
Authors: Pierre Fillâtre, Alexandra Mailles, Jean Paul Stahl, Ronan Garlantezec, Marion Le Marechal, Pierre Tattevin, Laurent Almoyna-Martinez, Olivier Bouchaud, Thomas de Broucker, Fabrice Bruneel, Bernard Castan, Eric Denes, Olivier Epaulard, Jean-Louis Herrmann, Jérome Honnorat, Alexandra Mailles, Patrice Morand, François Raffi, France Roblot, Jean-Paul Stahl, Romain Sonneville, Pierre Tattevin, Sophie Abgrall, Guillaume Baille, Aurélie Baldolli, Kevin Bertrand, Julien Biberon, Charlotte Biron, Geneviève Blanchet-Fourcade, Mathieu Blot, Anne Bonnetain, Elisabeth Botelho-Nevers, David Boutoille, Hélène Brasme, Cédric Bruel, Rodolphe Buzele, Etienne Canouï, Bernard Castan, Charles Cazanave, Céline Cazorla, Thibault Challan-Belval, Pascal Chavanet, Catherine Chirouze, Tomasz Chroboczek, Johan Courjon, Thomas De Broucker, Arnaud De La Blanchardière, Etienne de Montmollin, Eric Denes, Aurélien Dinh, Olivier Epaulard, Pierre Fillatre, Emmanuel Forestier, Amandine Gagneux-Brunon, Nicolas Gaillard, Julien Gautier, François Goehringer, Simon Gravier, Isabelle Gueit, Thomas Guimard, Carole Henry, Jean-Etienne Herbrecht, Fanny Jomier, Snejana Jurici, Solene Kerneis, Jessica Krause, Manuela Le Cam, Marion Le Maréchal, Gwenael Le Moal, Paul Le Turnier, Raphael Lecomte, Anne-Sophie Lecompte, Romain Lefaucheur, Olivier Lesieur, Philippe Lesprit, Guillaume Louis, Rafael Mahieu, Alain Makinson, Guillaune Marc, Alexandre Maria, Nathalie Marin, Guillaume Martin-Blondel, Martin Martinot, Alexandre Mas, Philippe Mateu, Laurence Maulin, Frédéric Mechai, Eugénie Mutez, Jérémie Orain, Anne Schieber-Pachart, Nathalie Pansu, Solene Patrat-Delon, Patricia Pavese, Hélène Pelerin, Véronique Pelonde-Erimée, Diane Ponscarme, Mathilde Puges, Vincent Roubeau, Yvon Ruch, Isabelle Runge, Romain Sonneville, Pierre Tattevin, Saber Touati, Jean-Marie Turmel, Isabelle Tyvaert, Marc-Olivier Vareil, Virginie Vitrat, Heidi Wille, Mathieu Zuber, Emmanuel Canet, Jean Reignier, Adrien Wang
Journal: Clinical Microbiology and Infection (2024)
Endoscopic ultrasound-guided antegrade stenting combined with closure of the puncture route using self-assembling peptide solution in a jaundiced patient with ascites
Authors: Hirotsugu Maruyama, Kojiro Tanoue, Tatsuya Kurokawa, Yoshinori Shimamoto, Yuki Ishikawa-Kakiya, Akira Higashimori, Yasuhiro Fujiwara
Journal: Endoscopy (2024)

Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is not an established technique in patients with ascites. There have been reports of continuous ascites drainage [1]; however, most cases have had poorly controlled ascites for a long time and there is a concern that fistula formation in the HGS route may be insufficient, leading to biliary peritonitis. Recently, the application of self-assembling peptide solution has been reported to reduce drain output and complications [2]. Aiming for simpler endoscopic therapy, we report an innovative method for EUS-guided antegrade stenting (EUS-AS) using a thin needle and closure of the puncture path with a self-assembling peptide solution.
Double sticker over knife to assess myotomy and mucosectomy length during Zenker’s peroral endoscopic myotomy for Zenker’s diverticulum
Authors: Miguel Fraile-López, Carmen Ribes, Álvaro Terán, María Moris, Juan Carlos Rodríguez, María Jesús López Arias, Antonio Cuadrado Lavín
Journal: Endoscopy (2024)

Flexible endoscopic therapies are becoming increasing popular for the treatment of Zenker's diverticulum. In particular, Zenker's diverticulum peroral endoscopic myotomy (zPOEM) allows a selective and precise cut of the cricopharyngeal muscle under direct visualization, improving its effectiveness and safety [1]. A major concern regarding the length cut is the risk of perforation and/or difficulties in the incisional closure if the cut is extended beyond the fundus, or the risk of recurrence of dysphagia if the procedure is incomplete and/or there is an excess of mucosal flap remaining.
A new treatment for endoscopic ultrasound-guided vascular intervention: coiling with sclerotherapy for esophageal varices
Authors: Kazunori Nagashima, Manabu Ishikawa, Yasunori Inaba, Ken Kashima, Yasuhito Kunogi, Fumi Sakuma, Atsushi Irisawa
Journal: Endoscopy (2024)

In recent years, interventional endoscopic ultrasound (EUS) has been applied to the treatment of vascular lesions such as isolated gastric varices and intractable gastrointestinal bleeding [1]. For esophageal varices, it is usual to perform endoscopic injection sclerotherapy (EIS) or endoscopic variceal ligation (EVL) [2] [3]; however, varices of thick diameter without palisade vessels (so-called pipeline varices) are often difficult to treat [4]. This report is the world's first of a new treatment for EUS-guided vascular intervention using a combination of coiling with sclerotherapy for esophageal varices.
Novel specialized guidewire for bridging deployment into the right hepatic duct via endoscopic ultrasound-guided hepaticogastrostomy for malignant hilar biliary obstruction
Authors: Tadahisa Inoue, Rena Kitano, Tomoya Kitada, Kazumasa Sakamoto, Satoshi Kimoto, Jun Arai, Kiyoaki Ito
Journal: Endoscopy (2024)

Endoscopic ultrasound (EUS)-guided biliary drainage is a useful salvage technique when endoscopic retrograde cholangiopancreatography (ERCP) fails. However, achieving bilateral drainage under EUS guidance presents significant challenges, particularly in cases of malignant hilar biliary obstruction [1]. One reported method involves bridging the right hepatic duct combined with EUS-guided hepaticogastrostomy (EUS-HGS) [2]. Despite the use of this approach, navigating a guidewire can be particularly difficult when the bifurcation angle between the right and left hepatic ducts is acute.
Endoscopic hot snare resection of a type III biliary cyst (choledochocele)
Authors: Andrea Sorge, Stefano Mazza, Francesca Torello Viera, Aurelio Mauro, Davide Scalvini, Alessandro Vanoli, Andrea Anderloni
Journal: Endoscopy (2024)

A 24-year-old man was referred to our unit for an incidentally diagnosed duodenal cystic lesion. Magnetic resonance cholangiopancreatography revealed a cystic lesion, measuring 30 × 35 mm, located near the major papilla, protruding into the duodenal lumen ([Fig. 1]) and containing biliary stones.
Intraoperative dual laparoscopy and neo-rectoscopy for precise excision of bowel endometriosis
Authors: Yunxi Zheng, Hao Zhang, Kaikai Chang, Shouxin Gu, Yun Chen, Junjie Xing, Xiaofang Yi
Journal: Endoscopy (2024)

Surgical treatment for bowel endometriosis poses a significant challenge for gynecologists [1]. The decision between shaving, disc resection, or segmental resection remains uncertain for both gynecologists and general surgeons. More precise surgical intervention reduces tissue damage and lowers recurrence rates [2]. Previously, dual endoscopic techniques have demonstrated significant advantages in detecting esophageal-jejunal anastomotic fistulas [3]. However, there is currently no published evidence of this method being applied to the treatment of endometriosis. Here, we report the use of intraoperative dual laparoscopy and neo-rectoscopy for the precise excision of bowel endometriosis.
Use of the intrascope channel stent release technique using a novel pigtail-type plastic stent
Authors: Masafumi Watanabe, Kosuke Okuwaki, Tomohisa Iwai, Kai Adachi, Akihiro Tamaki, Taro Hanaoka, Chika Kusano
Journal: Endoscopy (2024)

Endoscopic retrograde cholangiopancreatography (ERCP) with plastic stent placement is well established for managing biliary obstruction. Although pigtail-type plastic stents have a lower migration risk compared with straight plastic stents, their design necessitates that there is a longer length protruding from the papilla. To maintain an adequate distance between the papilla and the endoscope, adjustments in the operating angle or forceps elevator manipulation are critical during the deployment of pigtail plastic stents, making this a technically challenging procedure.
Retrieval technique for a sheared guidewire remnant in the gallbladder duct using a novel basket catheter
Authors: Sho Ishikawa, Mitsuhito Koizumi, Masahito Kokubu, Yusuke Okujima, Yuki Numata, Teru Kumagi, Yoichi Hiasa
Journal: Endoscopy (2024)

Endoscopic transpapillary gallbladder drainage (ETGBD) is one of the most difficult endoscopic retrograde cholangiopancreatography (ERCP)-related procedures to perform, as it often causes adverse events in the gallbladder duct [1]. Retrieval is technically difficult if a sheared guidewire remnant remains in the gallbladder duct. Herein, we present a case in which a sheared guidewire remnant was successfully retrieved from the gallbladder duct using a novel basket catheter.
Novel endoscopic approach for safe and effective resection of duodenal neuroendocrine tumor
Authors: Shinpei Minami, Shuhei Fukunaga, Michita Mukasa, Daiki Ohzono, Hiroshi Tanaka, Tomoyuki Nakane, Hidetoshi Takedatsu
Journal: Endoscopy (2024)

A 76-year-old woman presented with a 10-mm duodenal neuroendocrine tumor (d-NET) located in the duodenal bulb and confined to the submucosa ([Fig. 1] a). Conventional endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) carries high risks of perforation and of obscuring the vertical margin. We have devised a method ([Video 1]) to provide an equivalent treatment option in facilities where the full-thickness resection and closure device is unavailable.
En bloc underwater endoscopic mucosal resection of a large laterally spreading tumor in the colon after endoscopic tattooing
Authors: Xing Hua Ma, Kengo Kasuga, Ayaki Isshiki, Shingo Ishihara, Takashige Masuo, Yoji Takeuchi, Toshio Uraoka
Journal: Endoscopy (2024)

Underwater endoscopic mucosal resection (UEMR) is an alternative technique to standard polypectomy for managing complex cases. The primary advantage of UEMR is that it causes less bowel lumen distension, potentially allowing the capture of a larger mucosal surface area [1].
Mucosal leak after peroral endoscopic myotomy: what to do?
Authors: Francesco Cocomazzi, Marco Gentile, Sonia Carparelli, Laura Varano, Francesco Perri
Journal: Endoscopy (2024)

Peroral endoscopic myotomy (POEM) is becoming the first-line therapy for achalasia. It is a safe and minimally invasive treatment with a low rate of adverse events (AEs). The integrity of the mucosal flap at the end of POEM and adequate closure of the incision site are essential to avoiding AEs [1] [2] [3] [4] [5]. Postoperative AEs (e.g. leaks, late mucosal perforations) are considered difficult to diagnose and manage [4].
Fully endoscopic treatment of loss of anatomical continuity of the duodenum caused by a perforated ulcer: an auto-rendezvous by anterograde biliary route
Authors: Maria Terrin, Dima Hammoud, Roberta Maselli, Hadrien Tranchart, Ibrahim Dagher, Alessandro Repici, Gianfranco Donatelli
Journal: Endoscopy (2024)

Recanalization after total loss of luminal patency in a hollow organ is generally performed surgically, but in unfit patients it may not be feasible, and some reports suggest that endoscopic reconstruction with extra-anatomic rendezvous is a viable option [1].
Bipolar forceps coagulation for endoscopic papillectomy-related bleeding
Authors: Kozue Shibasaki, Haruo Miwa, Yuichi Suzuki, Kazuki Endo, Ritsuko Oishi, Hiromi Tsuchiya, Shin Maeda
Journal: Endoscopy (2024)

Endoscopic papillectomy is widely performed as a less invasive procedure for ampullary tumors compared with surgery [1] [2]; however, it occasionally causes refractory bleeding. Endoscopic hemostasis with clipping or electrocoagulation is used for pulsatile bleeding [3]; however, there is a risk of perforation at the post-endoscopic papillectomy ulcer. Under these conditions, electrocoagulation using bipolar hemostatic forceps (Hemostat Y; Pentax, Tokyo, Japan) effectively minimizes the risk of excessive tissue injury [4] [5]. Herein, we report two cases of endoscopic papillectomy-related bleeding that were successfully treated using bipolar forceps ([Video 1]).
Detection of decline in pulmonary function in patients with systemic sclerosis-associated interstitial lung disease using home monitoring in the Netherlands (DecreaSSc): a prospective, observational study
Authors: Arthiha Velauthapillai, Catharina C Moor, Jeska K de Vries-Bouwstra, Marlies S Wijsenbeek-Lourens, Cornelia H M van den Ende, Madelon C Vonk
Journal: The Lancet Rheumatology (2024)
Deeply embedded esophageal fishbone removed by endoscopic submucosal dissection
Authors: Sechiv Jugnundan, Sarang Gupta, Sunil Gupta, Katarzyna M. Pawlak, Christopher Teshima
Journal: Endoscopy (2024)

A 50-year-old man presented to the emergency department with chest pain and odynophagia after eating fish. Physical examination and X-ray of the neck were unremarkable. Computed tomography (CT) of the chest showed a fishbone embedded within the muscularis propria of the esophagus ([Fig. 1] a). We then performed an endoscopic ultrasonography (EUS), which localized the fishbone to the posterior wall ([Fig. 2]). A small mucosal defect was also noted.
Endoscopic ultrasound-guided choledochoduodenostomy using an innovatively shaped self-expandable metal stent to prevent stent migration
Authors: Takeshi Ogura, Takafumi Kanadani, Nobuhiro Hattori, Kimi Bessho, Hiroki Nishikawa
Journal: Endoscopy (2024)

Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) is now widely performed, not only as an alternative biliary drainage technique when endoscopic retrograde cholangiopancreatography (ERCP) fails, but also as primary drainage for unresectable malignant distal biliary obstruction [1] [2] [3]. The adverse event of stent migration sometimes occurs. In addition, EUS-CDS using a lumen-apposing metal stent (LAMS) has been reported, but if the common bile duct is not very dilated, this technique might be challenging, and misdeployment might occur, especially in nonexpert hands.