tbuckley/cabot-search huggingface dataset:
The Future of Plant-Based Diets: Aligning Healthy Marketplace Choices with Equitable, Resilient, and Sustainable Food Systems
Authors: Vivica I. Kraak, Jessica Aschemann-Witzel
Journal: Annual Review of Public Health (2024)

The future of plant-based diets is a complex public health issue inextricably linked to planetary health. Shifting the world's population to consume nutrient-rich, plant-based diets is among the most impactful strategies to transition to sustainable food systems to feed 10 billion people by 2050. This review summarizes how international expert bodies define sustainable diets and food systems and describes types of sustainable dietary patterns. It also explores how the type and proportion of plant- versus animal-source foods and alternative proteins relate to sustainable diets to reduce diet-related morbidity and mortality. Thereafter, we synthesize evidence for current challenges and actions needed to achieve plant-based sustainable dietary patterns using a conceptual framework with principles to promote human health, ecological health, social equity, and economic prosperity. We recommend strategies for governments, businesses, and civil society to encourage marketplace choices that lead to plant-rich sustainable diets within healthy, equitable, and resilient agroecological food systems.
Violence Against Women as a Global Public Health Issue
Authors: Heidi Stöckl, Susan B. Sorenson
Journal: Annual Review of Public Health (2024)

Violence against women, especially intimate partner violence, is recognized as a global public health issue due to its prevalence and global reach. This article outlines the scope of the issue, with respect to its prevalence, health outcomes, and risk factors, and identifies key milestones that led to its global recognition: methodological and data advances, acknowledgment as a criminal justice and health issue, support by the global women's movement, and the robust evidence demonstrating that intimate partner violence is preventable. Key issues for the future include recognition and consideration of intersectionality in research, improvements in the measurement of other forms of violence against women, and the need to scale up prevention efforts that have documented success. Violence against women is an urgent priority as it affects individuals, their families and surroundings, and the entire global health community.
Comparison of drug-eluting bead with conventional transcatheter arterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombus: A randomized clinical trial
Authors: Tan-Yang Zhou, Guo-Fang Tao, Guan-Hui Zhou, Yue-Lin Zhang, Tong-Yin Zhu, Sheng-Qun Chen, Hong-Liang Wang, Bao-Quan Wang, Li Jing, Feng Chen
Journal: International Journal of Surgery (2024)

Background: Drug-eluting bead transarterial chemoembolization (DEB-TACE) has shown efficacy for treating hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). However, whether DEB-TACE is superior to conventional TACE (cTACE) remains unclear. Objective: This randomized controlled trial aimed to compare the efficacy and safety of DEB-TACE versus cTACE in treating HCC with PVTT. Methods: The study was conducted at a tertiary care center in Southeast China. HCC patients with PVTT were randomized at a 1:1 ratio into the DEB-TACE or cTACE groups. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were overall survival (OS) and the incidence of adverse events (AEs). An independent review committee assessed the radiologic response according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST). AEs were assessed by the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Systemic therapies were not restricted. Results: Between September 2018 and July 2020, 163 patients were randomized to undergo DEB-TACE ( n =82) or cTACE ( n =81). Nine patients were excluded, and 154 patients were included in the final analysis; the median age was 55 years (range, 24–78 years), and 140 (90.9%) were male. The median PFS in the DEB-TACE group was 6.0 months (95% CI, 5.0–10.0) versus 4.0 months (95% CI, 3.0–5.0) in the cTACE group (hazard ratio, 0.63; 95% CI, 0.42–0.95; P =0.027). The DEB-TACE group showed a higher response rate [51 (66.2%) vs. 36 (46.8%); P =0.0015] and a longer median OS [12.0 months (95% CI, 9.0–16.0) vs. 8.0 months (95% CI, 7.0–11.0), P =0.039] than the cTACE group. Multivariate analysis showed that the treatment group, ALBI score, distant metastasis and additional TKIs were the four independent prognostic factors correlated with PFS. In addition, the treatment group, PVTT group and combination with surgery were independently associated with OS. AEs were similar in the two groups, and postembolization syndrome was the most frequent AE. Conclusion: DEB-TACE is superior to cTACE in treating HCC patients with PVTT, demonstrating improved PFS and OS with an acceptable safety profile, and may thus emerge as a promising treatment strategy for HCC patients with PVTT. Trial registration: Chinese Clinical Trial Registry ChiCTR1800018035.
Association between Combined Sewer Overflow Events and Gastrointestinal Illness in Massachusetts Municipalities with and without River-Sourced Drinking Water, 2014–2019
Authors: Beth M. Haley, Yuantong Sun, Jyotsna S. Jagai, Jessica H. Leibler, Robinson Fulweiler, Jacqueline Ashmore, Gregory A. Wellenius, Wendy Heiger-Bernays
Journal: Environmental Health Perspectives (2024)

Combined sewer overflow (CSO) events release untreated wastewater into surface waterbodies during heavy precipitation and snowmelt. Combined sewer systems serve
Heat Exposure and Cause-Specific Hospital Admissions in Spain: A Nationwide Cross-Sectional Study
Authors: Hicham Achebak, Grégoire Rey, Zhao-yue Chen, Simon J. Lloyd, Marcos Quijal-Zamorano, Raúl Fernando Méndez-Turrubiates, Joan Ballester
Journal: Environmental Health Perspectives (2024)

More frequent and intense exposure to extreme heat conditions poses a serious threat to public health. However, evidence on the association between heat and specific diagnoses of morbidity is still limited. We aimed to comprehensively assess the short-term association between cause-specific hospital admissions and high temperature, including the added effect of temperature variability and heat waves and the effect modification by humidity and air pollution.
Advanced microbiome therapeutics as a novel modality for oral delivery of peptides to manage metabolic diseases
Authors: Ruben Vazquez-Uribe, Karl Alex Hedin, Tine Rask Licht, Max Nieuwdorp, Morten O.A. Sommer
Journal: Trends in Endocrinology and Metabolism (2024)

The rising prevalence of metabolic diseases calls for innovative treatments. Peptide-based drugs have transformed the management of conditions such as obesity and type 2 diabetes. Yet, challenges persist in oral delivery of these peptides. This review explores the potential of 'advanced microbiome therapeutics' (AMTs), which involve engineered microbes for delivery of peptides in situ, thereby enhancing their bioavailability. Preclinical work on AMTs has shown promise in treating animal models of metabolic diseases, including obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease. Outstanding challenges toward realizing the potential of AMTs involve improving peptide expression, ensuring predictable colonization control, enhancing stability, and managing safety and biocontainment concerns. Still, AMTs have potential for revolutionizing the treatment of metabolic diseases, potentially offering dynamic and personalized novel therapeutic approaches.
Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure
Authors: Jiayao Chen, Shuhong Kuang, Jietao Cen, Yong Zhang, Zongshan Shen, Wei Qin, Qiting Huang, Zifeng Wang, Xianling Gao, Fang Huang, Zhengmei Lin
Journal: International Journal of Oral Science (2024)

Abstract The consumption of a high-fat diet (HFD) has been linked to osteoporosis and an increased risk of fragility fractures. However, the specific mechanisms of HFD-induced osteoporosis are not fully understood. Our study shows that exposure to an HFD induces premature senescence in bone marrow mesenchymal stem cells (BMSCs), diminishing their proliferation and osteogenic capability, and thereby contributes to osteoporosis. Transcriptomic and chromatin accessibility analyses revealed the decreased chromatin accessibility of vitamin D receptor (VDR)-binding sequences and decreased VDR signaling in BMSCs from HFD-fed mice, suggesting that VDR is a key regulator of BMSC senescence. Notably, the administration of a VDR activator to HFD-fed mice rescued BMSC senescence and significantly improved osteogenesis, bone mass, and other bone parameters. Mechanistically, VDR activation reduced BMSC senescence by decreasing intracellular reactive oxygen species (ROS) levels and preserving mitochondrial function. Our findings not only elucidate the mechanisms by which an HFD induces BMSC senescence and associated osteoporosis but also offer new insights into treating HFD-induced osteoporosis by targeting the VDR-superoxide dismutase 2 (SOD2)-ROS axis.
The Impact of China's Healthcare Reforms on Promoting Early Treatment for Femoral Neck Fractures
Authors: Wenyi Gan, Tengfeng Zhuang, Chongxuan Lu, Minying Xiong, Songwei Huan
Journal: International Journal of Surgery (2024)

Gan, Wenyi MD; Zhuang, Tengfeng MD; Lu, Chongxuan MD; Xiong, Minying MD; Huan, Songwei MD Author Information
Seedling root system adaptation to water availability during maize domestication and global expansion
Authors: Peng Yu, Chunhui Li, Meng Li, Xiaoming He, Danning Wang, Hongjie Li, Caroline Marcon, Yu Li, Sergio Perez-Limón, Xinping Chen, Manuel Delgado-Baquerizo, Robert Koller, Ralf Metzner, Dagmar van Dusschoten, Daniel Pflugfelder, Ljudmilla Borisjuk, Iaroslav Plutenko, Audrey Mahon, Marcio F R Resende, Silvio Salvi, Asegidew Akale, Mohanned Abdalla, Mutez Ali Ahmed, Felix Maximilian Bauer, Andrea Schnepf, Guillaume Lobet, Adrien Heymans, Kiran Suresh, Lukas Schreiber, Chloee M McLaughlin, Chunjian Li, Manfred Mayer, Chris-Carolin Schön, Vivian Bernau, Nicolaus von Wirén, Ruairidh J H Sawers, Tianyu Wang, Frank Hochholdinger
Journal: Nature Genetics (2024)
Cadonilimab with chemotherapy in HER2-negative gastric or gastroesophageal junction adenocarcinoma: the phase 1b/2 COMPASSION-04 trial
Authors: Xiangyu Gao, Ke Ji, Yongning Jia, Fei Shan, Ye Chen, Nong Xu, Ziyu Jia, Tianshu Liu, Nong Yang, Haijun Zhong, Changzheng Li, Zengqing Guo, Qingxia Fan, Xiaoyan Lin, Yan Zhang, Hui Ren, Hongxia Yang, Zhifang Yao, Wei Liu, Zhongmin Maxwell Wang, Baiyong Li, Michelle Xia, Lin Shen, Ziyu Li, Jiafu Ji
Journal: Nature Medicine (2024)
Two-year safety outcomes of iPS cell-derived mesenchymal stromal cells in acute steroid-resistant graft-versus-host disease
Authors: Kilian Kelly, Adrian J C Bloor, James E Griffin, Rohini Radia, David T Yeung, John E J Rasko
Journal: Nature Medicine (2024)

Abstract The first completed clinical trial of induced pluripotent stem cell (iPS cell)-derived cells was conducted in 15 participants with steroid-resistant acute graft-versus-host disease. After intravenous infusion of mesenchymal stromal cells (CYP-001 derived from a clone of human iPS cells), we reported the safety, tolerability and efficacy within the primary evaluation period at day 100. We now report results at the 2-year follow-up: 9 of 15 (60%) participants survived, which compares favorably with previously reported outcomes in studies of steroid-resistant acute graft-versus-host disease. Causes of death were complications commonly observed in recipients of allogeneic hematopoietic stem cell transplantation, and not considered by the investigators to be related to CYP-001 treatment. There were no serious adverse events, tumors or other safety concerns related to CYP-001. In conclusion, systemic delivery of iPS cell-derived cells was safe and well tolerated over 2 years of follow-up, with sustained outcomes up to 2 years after the first infusion. ClinicalTrials.gov registration: NCT02923375 .
Simple Behavioral Analysis (SimBA) as a platform for explainable machine learning in behavioral neuroscience
Authors: Nastacia L Goodwin, Jia J Choong, Sophia Hwang, Kayla Pitts, Liana Bloom, Aasiya Islam, Yizhe Y Zhang, Eric R Szelenyi, Xiaoyu Tong, Emily L Newman, Klaus Miczek, Hayden R Wright, Ryan J McLaughlin, Zane C Norville, Neir Eshel, Mitra Heshmati, Simon R O Nilsson, Sam A Golden
Journal: Nature Neuroscience (2024)
Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism
Authors: Shuai Tan, Jacobo L. Santolaya, Tiffany Freeney Wright, Qi Liu, Teppei Fujikawa, Sensen Chi, Colin P. Bergstrom, Adam Lopez, Qing Chen, Goncalo Vale, Jeffrey G. McDonald, Andrew Schmidt, Nguyen Vo, Jiwoong Kim, Hamid Baniasadi, Li Li, Gaohui Zhu, Tong-Chuan He, Xiaowei Zhan, Yuuki Obata, Aishun Jin, Da Jia, Joel K. Elmquist, Luis Sifuentes-Dominguez, Ezra Burstein
Journal: Nature Metabolism (2024)
Pan-transcriptome reveals a large accessory genome contribution to gene expression variation in yeast
Authors: Élodie Caudal, Victor Loegler, Fabien Dutreux, Nikolaos Vakirlis, Élie Teyssonnière, Claudia Caradec, Anne Friedrich, Jing Hou, Joseph Schacherer
Journal: Nature Genetics (2024)

Gene expression is an essential step in the translation of genotypes into phenotypes. However, little is known about the transcriptome architecture and the underlying genetic effects at the species level. Here we generated and analyzed the pan-transcriptome of ~1,000 yeast natural isolates across 4,977 core and 1,468 accessory genes. We found that the accessory genome is an underappreciated driver of transcriptome divergence. Global gene expression patterns combined with population structure showed that variation in heritable expression mainly lies within subpopulation-specific signatures, for which accessory genes are overrepresented. Genome-wide association analyses consistently highlighted that accessory genes are associated with proportionally more variants with larger effect sizes, illustrating the critical role of the accessory genome on the transcriptional landscape within and between populations.
Prevalence, incidence, mortality and healthcare resource use for generalized pustular psoriasis, palmoplantar pustulosis and plaque psoriasis in England: a population-based cohort study
Authors: Monika Frysz, Smit Patel, Marie Oy Yee Li, Christopher E M Griffiths, Richard B Warren, Darren M Ashcroft
Journal: British Journal of Dermatology (2024)

Abstract Background Generalized pustular psoriasis (GPP) and palmoplantar pustulosis (PPP) are chronic inflammatory skin conditions. Accumulating evidence shows that GPP and PPP have different characteristics to plaque psoriasis and are distinct clinical entities. Objectives To assess the epidemiology, comorbidities, mortality and healthcare use for patients in England with GPP and PPP versus those with plaque psoriasis. Methods We carried out a cohort study involving analyses of longitudinal electronic health record data in the Clinical Practice Research Datalink Aurum database and linked hospital and mortality data between 2008 and 2019. The primary study outcome was the incidence and prevalence rates of GPP, PPP and plaque psoriasis in England. Secondary outcomes included survival rates and healthcare resource use (HCRU) by disease type. Results We identified 373 patients with GPP, 1828 with PPP and 224 223 with plaque psoriasis. Mean (SD) age was 55.9 (18.6) years for patients with GPP, 51.5 (16.4) years for those with PPP and 48.5 (19.1) years for those with plaque psoriasis; 62.5% and 65.9% of patients with GPP and PPP, respectively, were women, vs. 49.4% of those with plaque psoriasis. About half of patients were overweight or obese at baseline (GPP 48.6%, PPP 56.0%, plaque psoriasis 45.9%). The incidence rates for GPP, PPP and plaque psoriasis were 0.25 [95% confidence interval (CI) 0.21–0.28], 2.01 (95% CI 1.92–2.11) and 103.2 (95% CI 102.5–103.9) per 100 000 person-years, respectively. From 2008 to 2019, the prevalence rates per 100 000 persons ranged from 1.61 to 3.0 for GPP, from 1.1 to 18.7 for PPP and from 1771.0 to 1903.8 for plaque psoriasis. Survival rates were lower for patients with GPP, particularly those who were &amp;gt; 55 years of age and those with a history of one or more comorbidities in each cohort. HCRU was lower in the cohort with plaque psoriasis and highest in the cohort with GPP, particularly among those who had more than one GPP flare. Conclusions Our results provide further evidence that, in England, GPP is a distinct disease with different epidemiology, lower survival and higher HCRU than plaque psoriasis.
Fluorescence‐Guided Spatial Drug Screening in 3D Colorectal Cancer Spheroids
Authors: Jia Ning Nicolette Yau, Thirumal Yempala, Ram Pravin Kumar Muthuramalingam, Giulio Giustarini, Germaine Teng, Wee Han Ang, Dan Gibson, Giulia Adriani, Giorgia Pastorin
Journal: Advanced Healthcare Materials (2024)

The limited recapitulation of critical cancer features in 2D cultures causes poor translatability of preclinical results from in vitro assays to in vivo tumor models. This contributes to slow drug development with a low success rate. 3D cultures better recapitulate the tumor microenvironment, enabling more accurate predictions when screening drug candidates and improving the development of chemotherapeutics. Platinum (Pt) (IV) compounds are promising prodrugs designed to reduce the severe systemic toxicity of widely used Food and Drug Administration (FDA)-approved Pt(II) drugs such as cisplatin. Here, this work presents spatiotemporal evaluations in 3D colorectal cancer (CRC) spheroids of mitochondria-targeting Pt(IV) complexes. CRC spheroids provide a greater pathophysiological recapitulation of in vivo tumors than 2D cultures by a marked upregulation of the ABCG2 chemoresistance marker expression. Furthermore, new 3D-staining protocols are introduced to evaluate the real-time decrease in mitochondria membrane potential (ΔΨ) in CRC spheroids, and a Pt-sensing dye to quantify the Pt mitochondrial accumulation. Finally, this work demonstrates a correlation between in vitro results and the efficacy of the compounds in vivo. Overall, the CRC spheroids represent a fast and cost-effective model to assess the behavior of Pt compounds in vitro and predict their translational potential in CRC treatment.
Renal cell carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
Authors: T. Powles, L. Albiges, A. Bex, E. Comperat, V. Grünwald, R. Kanesvaran, H. Kitamura, R. McKay, C. Porta, G. Procopio, M. Schmidinger, C. Suarez, J. Teoh, G. de Velasco, M. Young, S. Gillessen
Journal: Annals of Oncology (2024)
Multifunctional Conductive Hydrogel Interface for Bioelectronic Recording and Stimulation
Authors: Hao Tang, Yuanfang Li, Shufei Liao, Houfang Liu, Yancong Qiao, Jianhua Zhou
Journal: Advanced Healthcare Materials (2024)

The past few decades have witnessed the rapid advancement and broad applications of flexible bioelectronics, in wearable and implantable electronics, brain-computer interfaces, neural science and technology, clinical diagnosis, treatment, etc. It is noteworthy that soft and elastic conductive hydrogels, owing to their multiple similarities with biological tissues in terms of mechanics, electronics, water-rich, and biological functions, have successfully bridged the gap between rigid electronics and soft biology. Multifunctional hydrogel bioelectronics, emerging as a new generation of promising material candidates, have authentically established highly compatible and reliable, high-quality bioelectronic interfaces, particularly in bioelectronic recording and stimulation. This review summarizes the material basis and design principles involved in constructing hydrogel bioelectronic interfaces, and systematically discusses the fundamental mechanism and unique advantages in bioelectrical interfacing with the biological surface. Furthermore, an overview of the state-of-the-art manufacturing strategies for hydrogel bioelectronic interfaces with enhanced biocompatibility and integration with the biological system is presented. This review finally exemplifies the unprecedented advancement and impetus toward bioelectronic recording and stimulation, especially in implantable and integrated hydrogel bioelectronic systems, and concludes with a perspective expectation for hydrogel bioelectronics in clinical and biomedical applications.
SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites
Authors: Kaixiang Zhu, Lili Song, Linyue Wang, Lei Hua, Ziyu Luo, Tongyun Wang, Bo Qin, Shuofeng Yuan, Xiaopan Gao, Wenyi Mi, Sheng Cui
Journal: Acta Pharmaceutica Sinica B (2024)

Viruses often manipulate ubiquitination pathways to facilitate their replication and pathogenesis. CUL2
Advancing Ophthalmic Delivery of Flurbiprofen via Synergistic Chiral Resolution and Ion-pairing Strategies
Authors: Zhining Ma, Yuequan Wang, Huiyang He, Tong Liu, Qikun Jiang, Xiaohong Hou
Journal: Asian Journal of Pharmaceutical Sciences (2024)

Flurbiprofen (FB), a nonsteroidal anti-inflammatory drug, is widely employed in treating ocular inflammation owing to its remarkable anti-inflammatory effects. However, the racemic nature of its commercially available formulation (Ocufen®) limits the full potential of its therapeutic activity, as the (
<i>Prevotella copri</i> exhausts intrinsic indole-3-pyruvic acid in the host to promote breast cancer progression: inactivation of AMPK via UHRF1-mediated negative regulation
Authors: Jiyan Su, Xiaojie Lin, Dan Li, Chunmin Yang, Shumei Lv, Xiaohong Chen, Xiujuan Yang, Botao Pan, Rui Xu, Liping Ren, Yanfang Zhang, Yizhen Xie, Qianjun Chen, Chenglai Xia
Journal: Gut Microbes (2024)

Emerging evidence has revealed the novel role of gut microbiota in the development of cancer. The characteristics of function and composition in the gut microbiota of patients with breast cancer patients has been reported, however the detailed causation between gut microbiota and breast cancer remains uncertain. In the present study, 16S rRNA sequencing revealed that