AB0849 ULTRASOUND ELASTOGRAPHY IN ASSESSMENT OF SALIVARY GLANDS IN PRIMARY SJOGREN´S SYNDROME
Authors: J. Rojano, O. Sedano, L. Chinchay
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Several recent studies have shown that SWE of the major salivary glands is a potentially useful parameter for the diagnosis of primary Sjogren's syndrome (pSS) <h3>Objectives:</h3> This study aimed to investigate the diagnostic performance of SWE in pSS and its correlation with B-mode findings. <h3>Methods:</h3> The four major salivary glands (parotid and submandibular glands, bilaterally) were assessed by SWE and B-mode modalities by 2 and 3 independent operators, respectively, blinded to the diagnosis. B mode scans were rated using the However score, and mean shear-wave velocity (SWV) values were obtained from 3 different measures for each gland. Student's t-test, chi-square test and Pearson's correlation were performed to compare data, as appropriate. Inter and intra-rater reliability were calculated using intraclass-correlation coefficient (ICC). Cut-off values for differentiating pSS patients from controls were calculated using Receiver-Operating Characteristics (ROC) curves. <h3>Results:</h3> We included 16 pSS patients (mean (SD) age 55.2 (13.7); 98.0% females) and 12 controls (mean (SD) age 54.5 (9.2); 96.0% females) For SWE and B-mode modalities, inter-rater reliability was moderate to good (ICC: 0.64 and ICC:0.78-0.95, respectively), while intra-rater reliability was good to excellent (ICC:0.74-0.83 and ICC:0.95-0.98, respectively). Hocevar scores were higher in pSS patients than in controls (p&lt; 0.001) in all four glands examined. The mean total SWV (2.09 m/s (0.32); p&lt; 0.001), mean parotid SWV (2.25 m/s (0.53)) and mean submandibular SWV values (2.41 m/s (0.36)) were significantly higher in patients than in controls (2.21 m/s) (0.28). No significant correlation between Hocevar scores and SWV values was observed. The cut-offs of 2.05 m/s, 2.10 m/s and 2.12 m/s for total, parotid and submandibular SWV values differentiated pSS patients from controls with sensitivity of 65.3%, 77.6% and 79.2% and specificity of 80.0%, 88.0% and 84.0%, respectively. The area under the ROC curve (AUROC) was not significantly different between total SWV (AUROC=0.78) and parotid SWV (AUROC=0.81), p=0.696. Both were significantly greater than AUROC for submandibular SWV (AUROC=0.68), p&lt; 0.05 <h3>Conclusion:</h3> SWE may represent a relevant additional tool for the diagnosis of pSS. SWV values did not correlate with B-mode, probably due to the difficulty in scoring severely fibrotic glands using Hocevar score. Larger studies including patients with pSS and patients with sicca syndrome, as well as standardization of SWE protocols, are warranted to assess the role of SWE in the diagnostic algorithm of pSS. <h3>REFERENCES:</h3> [1] Chen S, Wang Y, Chen S, Wu Q, Chen S. Virtual Touch quantification of the salivary glands for diagnosis of primary Sjogren syndrome. J Ultrasound Med. 2016;35:2607–2613. [2] Jousse-Joulin S, Milic V, Jonsson MV, Plagou A, Theander E, Luciano N, et al. Is salivary gland ultrasonography a useful tool in Sjogren's syndrome? A systematic review. Rheumatology (Oxford) 2016;55:789–800 <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>