tbuckley/cabot-search huggingface dataset:
Technique of Tissue Culture "In Vitro."
Authors: T. S. P. Strangeways
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Multicenter Randomized Trial Comparing a Mechanical CPR Algorithm Using LUCAS Versus Manual CPR in Out-of-Hospital Cardiac Arrest Patients-Per Protocol Analysis of the LINC Study
Authors: Sten Rubertsson, Erik Lindgren, Ollie Östlund, Johan Herlitz, Rolf Karlsten
Journal: Circulation (2013)

A Multicenter Randomized Trial Comparing a Mechanical CPR Algorithm Using LUCAS Versus Manual CPR in Out-of-Hospital Cardiac Arrest Patients-Per Protocol Analysis of the LINC Study
Sexual health of teenagers
Authors: A. Noone, J. Chalmers, M. Hollinsworth, K. McIntyre, B. Cant, C. J Seamark, H. E Reiss, A. Nicoll, M. Catchpole
Journal: BMJ (1999)

Editor—Nicoll and colleagues report large percentage increases between 1995 and 1996 in indicators of sexual health in English teenagers.1 This is clearly of concern given the potential for serious health and social consequences. But it is important to look at trends in these various indicators over a longer period in order to obtain an accurate picture and to be aware of the impact on these of other, sometimes transient, factors.
The Green and Red Planet: A Physiological Study of the Possibility of Life on Mars
Authors: Hubertus Strughold, Green Peyton
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcomes in 708 resected stage I non-small cell lung cancer (NSCLC) subjects and a prognostic index for relapse
Authors: B. Goodgame, A. Viswanathan, G. Pillot, F. Gao, D. Morgensztern, J. Bradley, T. Guthrie, R. Battafarano, R. Govindan
Journal: Journal of Clinical Oncology (2005)

7198 Background: The five year survival rates for patients with stage I NSCLC treated with surgery alone range from 55% to 75%. Adjuvant chemotherapy improves survival in resected stage I NSCLC. There are no reliable markers (clinical or molecular) to predict recurrent disease. Methods: Patients included in this study had resection of stage I NSCLC from 1990 to 2000 at Barnes Jewish Hospital/Washington University School of Medicine. Our primary goal was to identify predictive factors for relapse in resected stage I NSCLC. Univariate analysis for associations with relapse was performed by X2 tests. A multivariate logistic regression model was fitted to identify independent predictors and construct prognostic groups. Results: 708 subjects were included in the analysis. Median duration of FU was 5.1 yrs. Characteristics: mean age 66 years (range 27–88); male: 53%; current or former smokers: 92%; T2: 49%. 87% had an anatomic resection with lobectomy being the most common procedure performed. Histology: adenocarcinoma (45%), squamous (36%) others (19%). 34% were poorly differentiated. Survival/Recurrence: Median and 5 yr survival rates were 5.2 yrs and 53%. Recurrence rates were 24% overall, 19% in T1, and 29% in T2. In the T2 subset, relapse rates were higher in patients with adenocarcinoma (35%) than in squamous cell type (21%). Four factors were significantly associated with relapse in the entire cohort of 708 patients: tumor size > 3cm (p<0.001, OR=2.2), invasion through visceral pleura (p=.004, OR=2.7), poor differentiation (p=.01, OR=1.7), and surgery other than lobectomy (p=.001, OR=2.1). Subjects were divided into prognostic groups according to the number of risk factors (RFs). Recurrence rates for 0, 1, 2, or 3 RF’s were 13%, 21%, 39%, and 50%. The relative risks of recurrence, as compared to no RFs, for 1, 2, or 3 RF’s were 1.68, 3.06, and 3.70. Conclusions: Combining RFs predicts relapse better than T stage in resected stage I NSCLC. This data should be prospectively validated. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AstraZeneca, Aventis, Bristol-Myers Squibb, Genentech, Lilly Oncology, Merck, Pfizer AstraZeneca, Aventis, Bristol-Myers Squibb, Ligand, Lilly Oncology, Pfizer
Articular Cartilage and Osteoarthritis
Authors: Joseph A Buckwalter, Henry J Mankin, Alan J Grodzinsky
Journal: BMJ (1954)

Articular cartilage, which makes possible the painless, low-friction movement of synovial joints, consists of a sparsely distributed population of highly specialized cells called chondrocytes that are embedded within a matrix and provide articular cartilage with remarkable mechanical properties. Chondrocytes form the tissue matrix macromolecular framework from three classes of molecules: collagens, proteoglycans, and noncollagenous proteins. The matrix protects the cells from injury resulting from normal joint use, determines the types and concentrations of molecules that reach the cells, acts as a mechanical signal transducer for the cells, and helps maintain the chondrocyte phenotype. Throughout life, articular cartilage undergoes internal remodeling as the cells replace matrix macromolecules lost through degradation. Aging decreases the ability of chondrocytes to maintain and restore articular cartilage and thereby increases the risk of degeneration of the articular cartilage surface. Progressive degeneration of articular cartilage leads to joint pain and dysfunction that is clinically identified as osteoarthritis. Investigation regarding the pathogenesis of posttraumatic osteoarthritis, the form of osteoarthritis that develops following joint injury, is helping to explain the development and progression of joint degeneration.
Genito-Urinary Diseases and Syphilis.
Authors: Edgar Garrison Ballenger
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Loss Of Major Molecular Response As a Trigger For Restarting Tyrosine Kinase Inhibitor Therapy In CP-CML Patients Who Have Stopped Imatinib After Durable Undetectable Minimal Residual Disease
Authors: Philippe Rousselot, Aude Charbonnier, Pascale Cony-Makhoul, Philippe Agape, Franck E Nicolini, Bruno R. Varet, Martine Gardembas, Gabriel Etienne, Delphine Rea, Lydia Roy, Martine Escoffre-Barbe, Agnès Guerci-Bresler, Michel Tulliez, Stephane Prost, Marc Spentchian, Jean-Michel Cayuela, Josy Reiffers, Jean Claude Chomel, Ali G Turhan, Joelle Guilhot, Francois Guilhot, Francois-Xavier Mahon
Journal: Blood (2013)
Expression of Rbat in Xenopus Oocytes Induces An Amino-Acid Exchange System for Neutral and Dibasic Amino-Acids
Authors: F Lang, T Herzer, S Waldegger, F Schmidt, E Gulbins, M Palacin, J Biber, D Markovich, H Murer, AE Busch
Journal: Journal of the American Society of Nephrology (1994)
The Biology of Immunologic Disease.
Authors: Frank J. Dixon, David W. Fisher
Journal: Annals of Internal Medicine (1984)

Book reviews some have poor colour reproduction and others are at too low a power of magnification.Several would have bene- fited from the use of indicator arrows.However, this book is more than an atlas.The text is a well-written, concise, practical account of biopsy pathology based upon the author's own extensive experiences, and it is worth buying for this, especially by trainees with the hurdle of the MRCPath in front of them.Overall, this book is a very good read.If the printers had done a better job of colour reproduction, it would be excellent value at the price.
Abstract 14666: Pseudoaneurysms after TAVI Using the Prostar-XL system, a Comparison Corevalve and the Edwards Sapien XT Valve
Authors: Suzanne Fateh-Moghadam, Rezo Jorbenadze, Antonios Kilias, Michal Droppa, Patrik Htun, Meinrad Gawaz, Wolfgang Bocksch
Journal: Circulation (2014)

Background: Transfemoral aortic valve implantation (TAVI) requires large bore catheters. Access site and vascular complications, therefore are of concern. Beside major vascular complications, post-...
Abstract 15518: Overexpression of MicroRNA-210 Induces Cardiomyocyte Proliferation Through Inhibition of APC
Authors: Vien K Lai, Raghav Pandey, Shazia Durrani, Gang Ma, Shujia Jiang, Rafeeq P Ahmed
Journal: Circulation (2014)

Background: MicroRNAs (miRs) transcriptionally regulate various cell functions including survival, differentiation and proliferation. Here, we report that transgenic overexpression of miR-210 in mice promoted cardiomyocyte (CM) proliferation by the inhibition of Adenomatous polyposis coli (APC), a cell cycle inhibitor.

Methods and Results: miR-210 transgenic mice (miR-210 TG) were generated at the University of Cincinnati transgenic core using C57BL/6 mouse strain. Myocardial infarction was created by LAD ligation on 12 weeks old miR-210 TG and wild type (NTG) mice following which EDU was administrated at a dose of 500μg in 100μl/ IP injection on alternate days up to day 12. For long term studies 4 weeks after ligation echocardiography was performed, animals were sacrificed and the heart sections were analyzed for apoptosis and CMs proliferation. For short term studies animals were sacrificed 7 days after LAD ligation. TUNEL assay at day 7 showed significantly lower percentage of apoptotic CMs in miR-210 mice compared to that of controls (3.12±0.6% vs 6.13±0.8%, p<0.05). At day 7 miR-210 TG group showed a higher number of EDU+ CMs but were not significant when compared to that of controls. However, at week 4 after infarction, significantly higher percentage of EDU+ CMs were observed in miR-210 TG group compared to that of NTG (1.11±0.05% vs 0.47±0.01%, p<0.05). Echocardiography performed prior to euthanasia showed preserved cardiac function in mir-210 TG as compared to NTG as indicated by LVEF (45.2±1.06 vs 38.9±1 p<0.001) and LVFS (18.3±1 vs 15±1. Furthermore, mesenchymal stem cells (MSCs) from miR-210 mice displayed significantly lower level of APC protein compared to that of wild type mouse MSCs. Further studies to identify the in vitro proliferative potential of miR-210 were carried out using 7 day old neonatal rat CMs, miR-210 transfection showed a significant increase in proliferation in miR-210 TG group when compared to control (38.67 ± 3.37 vs 6.7 ± 3.24). Computational prediction and Luciferase assay indicated a direct relationship between miR-210 and APC ( 2 fold reduction in luciferase activity).

Conclusions: Transgenic overexpression of miR-210 in mice induces CM proliferation at least in part, through down regulation of APC.
Die unregelmässige Herztätigkeit.
Authors: K. F. Wenckebach, Hch. Winterberg
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of menstrual cycle phase and oral contraceptive use on serum lithium levels after a loading dose of lithium in normal women
Authors: S Chamberlain, P M Hahn, P Casson, R L Reid
Journal: American Journal of Psychiatry (1990)

Serum lithium levels were analyzed in six healthy, normal women during the midfollicular, midluteal, and premenstrual phases of their menstrual cycles after they had received 300 mg of lithium carbonate orally. An identical protocol was followed for seven women with artificial cycles induced by oral contraceptive steroids. Analysis of variance for repeated measures over time showed no significant differences between groups or between cycle phases. Therefore, hormonal effects of ovarian or contraceptive steroids per se do not appear to alter serum lithium concentrations. Other factors may account for changing lithium requirements during the menstrual cycle in some patients with affective illness.
Severity of overdose after restriction of paracetamol availability
Authors: C L Sheen
Journal: BMJ (2001)

Editor—Robinson et al report a reduction in the amount of paracetamol ingested in overdose since the introduction of reduced pack sizes and blister packing of over the counter paracetamol in September 1998.1 They found no change, however, in the incidence of hepatotoxicity. Their results contrast with those of other studies, which have shown a 21% reduction in episodes of hepatotoxicity and a 64% reduction in the development of severe hepatotoxicity.2,3

As they have stated, hepatic failure is rare if <12 g of paracetamol is ingested.4 But the median dose ingested in their study did not reach this level. It is thus unsurprising that the study included only five cases of hepatotoxicity; given this low number, it seems imprudent to claim that no change in incidence has occurred.

In addition, the paracetamol concentrations quoted in the paper are low, considering that concentrations >200 mg/l four hours after ingestion and >130 mg/l six hours after ingestion are used to guide the appropriate use of acetylcysteine treatment. Despite the low concentrations quoted, acetylcysteine was given to 25% and 31% of patients. This does not seem to accord with current practice recommendations.

Robinson et al conclude that the change in pack size had no effect on the incidence of severe liver failure. In our view, a stricter definition of paracetamol overdose is required if we are to make sense of the conflicting reports. Perhaps paracetamol overdose should be confined to subjects who claim to have taken an overdose and have a measurable serum concentration.

The burden of paracetamol poisoning on the NHS is high, with over 70 000 episodes a year in Britain.5 It is worrying that the recent measures have not had a more dramatic effect on this serious problem. If, as Turvill et al say,3 only a 21% reduction has been achieved then further measures such as limiting paracetamol to prescription only should be considered.
Long-term cardiac outcomes following low-dose anthracycline exposure
Authors: J. A. Wright, S. Reimold, A. Turoff, S. Brooks, B. Huet, D. Eshelman, N. Winick, K. Oeffinger
Journal: Journal of Clinical Oncology (2007)

9519 Background: Pediatric cancer survivors treated with moderate-high dose (=250mg/m 2 ) anthracycline therapy are known to be at risk for cardiac toxicity. It remains unclear what cardiac risk exists for survivors who received a low dose (&lt;250mg/m 2 ) therapy. Methods: Cardiac MRI and maximal VO 2max testing were performed on young adult survivors of childhood acute lymphoblastic leukemia (ALL). MRI measurements included ejection fraction (EF), left ventricular (LV) mass, end diastolic volume (EDV), end systolic volume (ESV), and concentricity (LV mass/EDV). Survivors who were treated with low dose anthracycline (&lt; 250mg/m 2 ) were compared to those without anthracycline exposure. Spearman correlations and multivariable linear regression were used to examine the relationship between anthracycline dose and measures of cardiac function and cardiorespiratory fitness. Results: Sixty-seven survivors (mean age 23.9 ±5 years) participated, including 39 (58.2%) females. The mean interval from cancer diagnosis to study was 17.4 ± 6.6 years. The number of participants by cumulative anthracycline dose were 19 (28.4%) with no exposure, 28 (41.8%) with doses of 1–249mg/m 2 , and 20 (29.8%) with doses of =250mg/m 2 . When adjusted for age and race, there was not a significant difference in the cardiac MRI outcomes and VO 2max levels between participants who received 1- 249mg/m 2 of anthracycline versus those without anthracycline exposure. Conclusions: With continued use of anthracyclines at cumulative low doses, particularly in ALL standard risk trials, it is important to determine if there is a long-term cardiotoxicity. With a mean follow-up of 17 years, our data support the safety of low cumulative dose anthracycline. [Table: see text] No significant financial relationships to disclose.
Abstract 16464: End Systolic Volume and Viability Assessed by Cardiac MRI Predicts Differential Survival in Patients With Severe Ischemic Cardiomyopathy Undergoing Revascularization vs. Medical Therapy: The Missing STITCH?
Authors: Deborah Kwon, Rory Hachamovitch, Zoran Popovic, Randall Starling, Milind Desai, Scott Flamm, Thomas Marwick
Journal: Circulation (2011)

Introduction: End systolic volume index (ESVi) and myocardial scar burden (MSB) are independent predictor of mortality in ischemic cardiomyopathy (ICM). The STITCH trial did not include cardiac MRI...
Nephrology: Proceedings of the IXth International Congress of Nephrology.
Authors: Roscoe R. Robinson
Journal: Annals of Internal Medicine (1985)

For many reasons, as President of the International Society of Nephrology, I am happy and honored to write a brief introduction to Nephrology, the Proceedings of the IXth International Congress of Nephrology. One of these reasons is specially treasured: I edited the two books published after our first Congress (Geneva-Evian 1960). The 1984 vintage will certainly be as good as the preceding ones. And, for any nephrologist, whatever his or her field of interest, many observations will be found in the Proceedings that will enhance their personal work. It is characteristic for our Congresses to be the converging point upon which many different orientations join together and form the nephrology that is researched and practiced throughout the world. What could replace a State-of-the-Art lecture delivered by a selected ne phrologist whose work is of the highest quality? At times, even more revealing are those presentations made by non-nephrologists, the basic scientists who bring us fresh data and new concepts far removed from the reader's daily world. But attending such a lecture is never enough. Their texts should be read and reread. Symposia and workshops, as sources of precise and up dated knowledge espoused by experts, are often heart-breaking as they shake established dogma. Therefore, they should be neither neglected nor forgotten but scrutinized carefully. The evidence which could eventually lead to new concepts or hypotheses has to be weighed accurately and then either rejected, discarded temporarily, or accepted, even if the latter implies dramatic change.
Lehrbuch der Lokalanästhesie des Ohres und der oberen Luftund Speisewege.
Authors: Caesar Hirsch, O. Voss
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal