tbuckley/cabot-search huggingface dataset:
Intermittent or Continuous Panitumumab Plus Fluorouracil, Leucovorin, and Irinotecan for First-Line Treatment of RAS and BRAF Wild-Type Metastatic Colorectal Cancer: The IMPROVE Trial
Authors: Antonio Avallone, Francesco Giuliani, Alfonso De Stefano, Giuseppe Santabarbara, Guglielmo Nasti, Vincenzo Montesarchio, Gerardo Rosati, Antonino Cassata, Silvana Leo, Carmela Romano, Emiliano Tamburini, Lucrezia Silvestro, Claudio Lotesoriere, Anna Nappi, Daniele Santini, Antonella Petrillo, Alfredo Colombo, Antonio Febbraro, Alessandra Leone, Francesco Mannavola, Maria Maddalena Laterza, Francesco Izzo, Alberto Sobrero, Paolo Delrio, Diana Giannarelli, Alfredo Budillon
Journal: Journal of Clinical Oncology (2024)

PURPOSE To investigate whether intermittent treatment after an induction phase of first-line schedule of fluorouracil, leucovorin, and irinotecan (FOLFIRI) plus panitumumab (PAN) prevents or delays the onset of resistance and improves safety and compliance with treatment in patients with unresectable RAS / BRAF wild-type (wt) metastatic colorectal cancer (mCRC). PATIENTS AND METHODS IMPROVE (ClinicalTrials.gov identifier: NCT04425239 ) was an open-label, multicenter, randomized phase II noncomparative trial. Patients with unresectable RAS / BRAF wt mCRC were randomly assigned (1:1) to receive FOLFIRI plus PAN continuously until progression (arm A) or intermittently, with treatment-free intervals (arm B) until progression on treatment, toxicity, or death. The primary end point was progression-free survival on treatment (PFSot) at 12 months. Assuming a null hypothesis of median PFSot time ≤7 months and target PFSot ≥10 months, 65 patients per arm were needed to achieve 80% power and 10% type I error, according to the binomial test. RESULTS Between May 2018 and June 2021, 69 patients were randomly assigned to arm A and 68 to arm B. The median number of treatment cycles was 13 in arm A and 16 in arm B. At a median follow-up of 43.2 months (IQR, 35.0-50.5), median PFSot was 11.2 and 17.5 months with 12-month PFSot rates of 45.7% and 58.5%, for arms A and B, respectively. The overall response rates were 68.1% and 61.2%, and median overall survival rates were 36.3 and 35.1 months in arms A and B, respectively. The overall rate of grade &gt;2 skin PAN-related adverse events was 30.3% in arm A and 17.9% in arm B. CONCLUSION Intermittent FOLFIRI plus PAN after the induction phase was feasible, and the primary end point was met with reduced toxicity while allowing patients more time off treatment.
Feasibility of long-range telesurgical robotic radical gastrectomy in a live porcine model
Authors: Daryl Kai Ann Chia, Koichi Suda, Wei-En Ho, Bu Sung Lee, Kazumitsu Suzuki, Susumu Shibasaki, Tatsuhiko Harada, Jun Murai, Masafumi Oe, Hirochika Asai, Takashi Tomine, Hirotaka Sato, Masahiro Yoro, Masanao Ohashi, Hiroaki Kitatsuji, Simon Peter Green, Ying Xiong, Asim Shabbir, Davide Lomanto, Jimmy Bok Yan So, Guowei Kim, Ichiro Uyama
Journal: International Journal of Surgery (2024)

Telesurgery has been made increasingly possible with the advancements in robotic surgical platforms and network connectivity. However, long-distance transnational complex robotic surgeries such as gastrectomy have yet to be attempted. Multiple transnational network connections by Science Innovation Network (SINET), Japan Gigabit Network (JGN), and Arterial Research and Education Network in Asia-Pacific (ARENA-PAC) were established and tested by multiple surgeons in a dry box model. Surgeons' perceptions of the different networks were recorded. Three robotic radical D2 gastrectomies in live porcine models were performed at a hospital in Toyoake, Japan, by a surgical team in a hospital in Singapore ~5000 km away, using the hinotori Surgical Robot System (Medicaroid Corporation). The live porcine robotic gastrectomies were all completed in under 205 min with no intraoperative complications. From the different networks that were tested, the differences in latency ranged from 107 to 132 ms and did not translate to any significant differences in surgeon timings and perceptions. Transnational telesurgical radical D2 gastrectomy is feasible in a porcine model. There is no appreciable difference between surgeon performance and perception with network latencies of 107-132 ms. Long-range telesurgery as clinical practice may become possible in the future.
Marburg virus disease outbreak in Rwanda, 2024
Authors: Martin P Grobusch, Pikka Jokelainen, Anne L Wyllie, Nitin Gupta, José Ramón Paño-Pardo, Aleksandra Barac, Casandra Bulescu, Galadriel Pellejero-Sagastizábal, Abraham Goorhuis, F-Xavier Lescure, Effrossyni Gkrania-Klotsas, Marta Mora-Rillo
Journal: Clinical Microbiology and Infection (2024)
Clinical and mycological outcomes of candidaemia and/or invasive candidiasis by Candida spp. and antifungal susceptibility: pooled analyses of two randomised trials of rezafungin versus caspofungin
Authors: Alex Soriano, Jeffrey B Locke, Oliver A Cornely, Emmanuel Roilides, Antonio Ramos-Martinez, Patrick M Honoré, Mariana Castanheira, Cecilia G Carvalhaes, Saad Nseir, Matteo Bassetti, Nick Manamley, Taylor Sandison, Maiken C Arendrup
Journal: Clinical Microbiology and Infection (2024)
Leptin augments IL-13-induced airway eotaxins and submucosal eosinophilia in obesity-associated asthma
Authors: Jennifer L Ingram, Victoria L McQuade, Jasmine Weiss, Jack T Womble, Mark D Ihrie, Karen Zhao, Dave Francisco, Barbara Theriot, Katelynn May, Haein Kim, Matthew McCravy, Maor Sauler, Njira L Lugogo, Mary E Sunday, Jeffrey Everitt, Julia K L Walker, Robert M Tighe, Monica Kraft, Loretta G Que
Journal: Journal of Allergy and Clinical Immunology (2024)
Immunomechanobiology: Engineering the Activation and Function of Immune Cells with the Mechanical Signal of Fluid Shear Stress
Authors: N. S. Sarna, N. M. Curry, E. Aalaei, B. G. Kaufman, M. R. King
Journal: IEEE Reviews in Biomedical Engineering (2024)

Immunomechanobiology, the study of how physical forces influence the behavior and function of immune cells, is a rapidly growing area of research. It is becoming increasingly recognized that mechanical stimuli, such as fluid shear forces, are a critical determinant of immune cell regulation. In this review, we discuss the principles and significance of various mechanical forces present within the human body, with a focus on fluid shear flow and its impact on immune cell activation and function. Moreover, we discuss engineering approaches used to study immune cell mechanobiology, and their implications in health and diseases such as cancer, autoimmune disorders, and infectious disease.
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
Authors: Jacki E. Heraud-Farlow, Scott R. Taylor, Alistair M. Chalk, Adriana Escudero, Shi-Bin Hu, Ankita Goradia, Tao Sun, Qin Li, Iva Nikolic, Jin Billy Li, Miguel Fidalgo, Diana Guallar, Kaylene J. Simpson, Carl R. Walkley
Journal: Science Immunology (2024)

Adenosine-to-inosine (A-to-I) editing of double-stranded RNA (dsRNA) by ADAR1 is an essential modifier of the immunogenicity of cellular dsRNA. The role of MDA5 in sensing unedited cellular dsRNA and the downstream activation of type I interferon (IFN) signaling are well established. However, we have an incomplete understanding of pathways that modify the response to unedited dsRNA. We performed a genome-wide CRISPR screen and showed that GGNBP2, CNOT10, and CNOT11 interact and regulate sensing of unedited cellular dsRNA. We found that GGNBP2 acts between dsRNA transcription and its cytoplasmic sensing by MDA5. GGNBP2 loss prevented induction of type I IFN and autoinflammation after the loss of ADAR1 editing activity by modifying the subcellular distribution of endogenous A-to-I editing substrates and reducing cytoplasmic dsRNA load. These findings reveal previously undescribed pathways to modify diseases associated with ADAR mutations and may be determinants of response or resistance to small-molecule ADAR1 inhibitors.
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation
Authors: Bernhard Ransmayr, Sevgi Köstel Bal, Marini Thian, Michael Svaton, Cheryl van de Wetering, Christoph Hafemeister, Anna Segarra-Roca, Jana Block, Alexandra Frohne, Ana Krolo, Melek Yorgun Altunbas, Sevgi Bilgic-Eltan, Ayça Kıykım, Omer Aydiner, Selin Kesim, Sabahat Inanir, Elif Karakoc-Aydiner, Ahmet Ozen, Ümran Aba, Aylin Çomak, Gökçen Dilşa Tuğcu, Robert Pazdzior, Bettina Huber, Matthias Farlik, Stefan Kubicek, Horst von Bernuth, Ingrid Simonitsch-Klupp, Marta Rizzi, Florian Halbritter, Alexei V. Tumanov, Michael J. Kraakman, Ayşe Metin, Irinka Castanon, Baran Erman, Safa Baris, Kaan Boztug
Journal: Science Immunology (2024)

Secondary lymphoid organs (SLOs) provide the confined microenvironment required for stromal cells to interact with immune cells to initiate adaptive immune responses resulting in B cell differentiation. Here, we studied three patients from two families with functional hyposplenism, absence of tonsils, and complete lymph node aplasia, leading to recurrent bacterial and viral infections. We identified biallelic loss-of-function mutations in LTBR, encoding the lymphotoxin beta receptor (LTβR), primarily expressed on stromal cells. Patients with LTβR deficiency had hypogammaglobulinemia, diminished memory B cells, regulatory and follicular T helper cells, and dysregulated expression of several tumor necrosis factor family members. B cell differentiation in an ex vivo coculture system was intact, implying that the observed B cell defects were not intrinsic in nature and instead resulted from LTβR-dependent stromal cell interaction signaling critical for SLO formation. Collectively, we define a human inborn error of immunity caused primarily by a stromal defect affecting the development and function of SLOs.
A Contemporary Picture of Coagulase-Negative Staphylococcal Endocarditis
Authors: Clara Palom-Grau, Guillermo Cuervo, Patricia Muñoz, Mercedes Marín Arriaza, Manuel Martínez-Sellés, Víctor González-Ramallo, Arístides de Alarcón, Manuel Poyato-Borrego, Raquel Rodríguez-García, M Ángeles Rodríguez-Esteban, M Carmen Fariñas, Claudia González-Rico, Miguel Ángel Goenaga, Guillermo Ojeda-Burgos, Ane Josune Goikoetxea-Agirre, Jorge Calderón-Parra, Juan Carlos López-Azor, Elisa García-Vázquez, Belén Loeches, Eduard Quintana, Cristina García de la Mària, Jaume Llopis, José M Miró
Journal: Journal of the American College of Cardiology (2024)
Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung adenocarcinoma
Authors: Yi-Feng Ren, Qiong Ma, Xiao Zeng, Chun-Xia Huang, Jia-Li Ren, Fang Li, Jia-Jing Tong, Jia-Wei He, Yang Zhong, Shi-Yan Tan, Hua Jiang, Long-Fei Zhang, Heng-Zhou Lai, Ping Xiao, Xiang Zhuang, Peng Wu, Li-Ting You, Wei Shi, Xi Fu, Chuan Zheng, Feng-Ming You
Journal: Molecular Cancer (2024)

Radiographically, ground-glass nodules (GGN) and part-solid nodules (PSN) in lung adenocarcinoma (LUAD) have significant heterogeneity in their clinical manifestations, biological characteristics, and prognosis. This study aimed to explore the heterogeneity of LUAD in different radiological phenotypes and associated factors influencing tumor evolution. We performed single-cell RNA sequencing (scRNA-seq) on tumor tissues from eight and seven cases of GGN– and PSN–LUAD, respectively, at different disease stages, including minimally invasive adenocarcinoma (MIA), invasive adenocarcinoma (IAC), and metastatic lung cancer (MLC). Additionally, we analyzed adjacent normal tissues from four cases. Immunohistochemistry, multiplex immunofluorescence, and external scRNA-seq data were employed to confirm the expression of signature genes as well as the distribution patterns of CXCL9 + TAMs and TREM2 + TAMs. A LUAD mouse model was generated using gene editing, organoid culture, and orthotopic transplantation techniques, and comprehensive analyses such as histopathology, RNA sequencing, and Western blotting were performed to validate key pathways. Diverse cellular compositions were observed in the tumor microenvironment (TME) during GGN– and PSN–LUAD invasion and metastasis. Notably, CXCL9 + and TREM2 + tumor-associated macrophages (TAMs) exhibited the most significant enrichment changes. It was found that GGN–LUAD exhibited a stronger immune response than PSN–LUAD, with increased interaction between CXCL9 + TAMs and CD8 + tissue-resident memory T cells during invasion stage (MIA–IAC). Conversely, greater interactions between TREM2 + TAMs and tumor cells were observed in PSN–LUAD during the MLC stage. Additionally, TREM2 + TAMs were found to differentiate into TREM2 + /SPP1 + and TREM2 + /SPP1– TAMs at different stages, which promotes tumor progression. This study also emphasizes that during the transdifferentiation process of GGN– and PSN–LUAD, IFN-γ activates the STAT1 signaling pathway to regulate the activation of CXCL9 + TAMs, and further recruiting CD8 + Trm cells and activating T cells through MHC class I antigen presentation. The role of the IFN-γ/STAT1 pathway in the occurrence and development of LUAD was further validated by animal experiments. Our findings offer a potential therapeutic strategy to maintain a dynamic balance within the TME and improve the immunotherapy efficacy by modulating the relative proportions and functional states of CXCL9 + TAMs and TREM2 + TAMs.
Engineering aortic valves via transdifferentiating fibroblasts into valvular endothelial cells without using viruses or iPS cells
Authors: Peng Tang, Fuxiang Wei, Weihua Qiao, Xing Chen, Chenyang Ji, Wanzhi Yang, Xinyu Zhang, Sihan Chen, Yanyan Wu, Mingxing Jiang, Chenyu Ma, Weiqiang Shen, Qi Dong, Hong Cao, Minghui Xie, Ziwen Cai, Li Xu, Jiawei Shi, Nianguo Dong, Junwei Chen, Ning Wang
Journal: Bioactive Materials (2024)
Enzymatic nanomotors with chemotaxis for product-based cancer therapy
Authors: Haixin Tan, Ziwei Hu, Jiajun Miao, Bin Chen, Huaan Li, Junbin Gao, Yicheng Ye, Wenxin Xu, Jiamiao Jiang, Hanfeng Qin, Hao Tian, Fei Peng, Yingfeng Tu
Journal: Journal of Controlled Release (2024)
Aspergillus-mediated allergic airway inflammation is triggered by dendritic cell recognition of a defined spore morphotype.
Authors: E L Houlder, S Gago, G Vere, J Furlong-Silva, D P Conn, E Hickey, S Khan, D Thomson, M W Shepherd, R Lebedinec, G D Brown, W Horsnell, M Bromley, A S MacDonald, P C Cook
Journal: Journal of Allergy and Clinical Immunology (2024)
Visual Loss in Geographic Atrophy: Learnings From the Lampalizumab Trials
Authors: Neha Anegondi, Verena Steffen, Srinivas R Sadda, Steffen Schmitz-Valckenberg, Adnan Tufail, Karl Csaky, Eleonora M Lad, Peter K Kaiser, Daniela Ferrara, Usha Chakravarthy
Journal: Ophthalmology (2024)
What is the role of epidemiological investigations in human Campylobacter outbreaks in the One Health and whole genome sequencing era in Denmark?
Authors: Johanna J Young, Stine Nielsen, Luise Müller, Guido Benedetti, Channie Kahl Petersen, Eva Møller Nielsen, Katrine Grimstrup Joensen
Journal: Clinical Microbiology and Infection (2024)
A Case Report
Authors: Fatema Mohd Al Sawafi, Olfat Kamel Hasan, Michael Bonert, Ehsan Haider, Bobby Shayegan
Journal: Clinical Nuclear Medicine (2024)

Prostate-specific membrane antigen (PSMA) PET/CT scan has significantly improved the detection and staging of prostate cancer. We report a rare case of a 72-year-old man with a history of Gleason score 7 (3 + 4) prostate adenocarcinoma, status post radical prostatectomy, referred for restaging PSMA PET/CT scan due to rising PSA (0.12 μg/L). The scan revealed a PSMA-avid lesion in the retroperitoneum, later confirmed via further investigations and histopathological analysis to be a retroperitoneal hemangioma. This case emphasizes the challenges in interpreting PSMA PET/CT scan in prostate cancer and highlights the significance of thorough consideration in forming a comprehensive differential diagnosis.
Uncovering Hidden Metastases at Unusual Site
Authors: Raza Abbas Mahdi, Dhananjaya Saraswat, Piyush Aggarwal, Ashwani Sood, Munish Kumar, Bhagwant Rai Mittal
Journal: Clinical Nuclear Medicine (2024)

Abstract Prostate cancer frequently metastasizes to bones; however, the detection of metastases can be challenging in rare locations. We present the case of a 76-year-old man with metastatic castration-resistant prostate cancer with lymph nodal and skeletal metastases who underwent 177 Lu–prostate-specific membrane antigen (PSMA) therapy. Initial 18 F-PSMA PET/CT scan acquired until the midthigh failed to identify metastases in the foot, but posttherapy 177 Lu-PSMA scan revealed the presence of metastases in the navicular and cuboid bones of the right foot, which is a very rare finding. This case highlights the limitations of standard PSMA PET/CT acquisition protocol and incremental value of whole-body posttherapy scan.
Cancer Integrin Imaging With 68Ga-Trivehexin PET-CT in Head and Neck Squamous Cell Carcinoma Improves Diagnostic Accuracy
Authors: Ralph Emerson, Kanhaiyalal Agrawal, Parneet Singh, P Sai Sradha Patro, Navneet Kumar
Journal: Clinical Nuclear Medicine (2024)

Abstract Oral squamous cell carcinoma (OSCC) is one of the most common malignancies worldwide. Locoregional nodal involvement by OSCC is commonly encountered. Current conventional and functional imaging modalities have limited diagnostic accuracy in nodal assessment, particularly in head and neck cancer. Thus, definitive management of head and neck malignancies customarily addresses the locoregional nodes along with the primary malignancy. However, OSCC, particularly tongue cancer, shows erratic lymphatic drainage and thus commonly requires extensive bilateral neck dissection, leading to significant morbidity. Cancer integrin imaging with 68 Ga-trivehexin PET-CT can offer highly specific result and thus has the potential for effective tailored management.
Lupus Nephritis Revealed by FAPI PET/CT
Authors: Wenjie Zhang, Zhongzhi Qi, Guohua Shen
Journal: Clinical Nuclear Medicine (2024)

Abstract A 38-year-old woman received a 68 Ga-FAPI-04 PET/CT scan for the evaluation of systemic lupus erythematosus. Diffuse uptake in both kidney parenchyma indicated the presence of lupus nephritis. In addition, an incidental carotid body tumor with increased FAPI uptake was also observed. Our case described the imaging features of lupus nephritis coexistent with a carotid body tumor on FAPI PET/CT.
11C-Methionine PET/CT in Cryptococcus Meningoencephalitis
Authors: Yoichi Otomi, Natsumi Teshima, Takayoshi Shinya, Hideki Otsuka, Masafumi Harada
Journal: Clinical Nuclear Medicine (2024)

Abstract A 70-year-old man experienced an epileptic seizure. Subsequent MRI performed on close examination revealed high signal in the left occipital cortex on fluid-attenuated inversion recovery. Gadolinium contrast indicated enhancement along the cortex. 11 C-Methionine PET/CT scan, performed to differentiate from a brain tumor, showed high uptake mainly along the left occipital lobe cortex. Spinal fluid examination revealed Cryptococcus neoformans , leading to a diagnosis of Cryptococcus meningoencephalitis.
Bilateral Glomus Caroticum With Rare Metastatic Sites Demonstrated on 68Ga-DOTATATE PET/CT
Authors: Nur Aydinbelge-Dizdar, Alev Cinar, Ayberk Inanir, Ozlem Ozmen
Journal: Clinical Nuclear Medicine (2024)

Abstract A 39-year-old woman with bilateral carotid body tumors was referred to 68 Ga-DOTATATE PET/CT for further evaluation. Unknown metastatic sites with increased 68 Ga-DOTATATE uptake were detected in the left cervical lymph node, liver, and bone. Carotid body paragangliomas (CBPs) represent less than 0.5% of all head and neck tumors and are rarely seen as metastatic disease. 68 Ga-DOTATATE PET/CT is a substantial imaging method for primary staging of CBPs, revealing unknown lesions, changing the treatment approaches and determining prognosis. We aimed to present the contribution of 68 Ga-DOTATATE PET/CT to patient management in a rare case of bilateral CBPs with rare metastatic sites.
Superiority of 68Ga-Trivehexin PET/CT Over 18F-FDG PET/CT in the Evaluation of Lymph Nodes in Patients With Breast Cancer
Authors: Halil Kömek, Yunus Güzel, İhsan Kaplan, Ece Eşsiz Yilmaz, Canan Can
Journal: Clinical Nuclear Medicine (2024)

A patient with left upper quadrant breast cancer who had 18F-FDG PET/CT imaging underwent 68Ga-Trivehexin PET/CT. 68Ga-Trivehexin PET/CT showed higher radiotracer accumulation in the primary tumor, left internal mammary lymph nodes, and axillary lymph nodes compared with 18F-FDG PET/CT. However, Trivehexin uptake was not observed in FDG-positive lymph nodes in the mediastinum and left hilar region. Benign cytological findings were noted in the biopsy of the subcarinal lymph node. This case demonstrates that the use of 68Ga-Trivehexin PET/CT in suspicious lymph nodes in areas difficult to biopsy in breast cancer cases can contribute to accurate staging.
Corrigendum to “Poly(β-amino ester) polymer library with monomer variation for mRNA delivery” [Biomaterials 314 (2025) 122896]
Authors: Hong Lyun Kim, Gurusamy Saravanakumar, Seowon Lee, Subin Jang, Seonwoo Kang, Mihyeon Park, Sivasangu Sobha, So-Hee Park, Soo-Min Kim, Jung-Ah Lee, Eunkyung Shin, You-Jin Kim, Hye-Sook Jeong, Dokeun Kim, Won Jong Kim
Journal: Biomaterials (2024)
Successful endoscopic ultrasound-guided drainage using contrast-enhanced harmonic imaging
Authors: Yuki Mori, Kosuke Iwano, Ryo Ito, Shunjiro Azuma, Toshihiro Morita, Katsutoshi Kuriyama, Shujiro Yazumi
Journal: Endoscopy (2024)

Contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) has been reported to be useful in the diagnosis of pancreatobiliary disease. CH-EUS facilitates the differentiation of the cystic component from the parenchymal component by assessing the presence of blood flow [1] [2]. Herein, we report a case of successful EUS-guided transluminal drainage (EUS-TD) for infected pancreatic fluid collection using CH-EUS.
Bringing light into darkness: peroral double-balloon enteroscopy-guided endoscopic injection sclerotherapy for a jejunal hemangioma
Authors: Fu-qiang Liu, Wei Zhao, Yu-ting Huang, Xiangrong Zhou, Zhi-qiang Du
Journal: Endoscopy (2024)

Small bowel bleeding accounts for 5–10% of all gastrointestinal bleeding cases, with small bowel hemangioma being one of the most common causes. It is characterized by an insidious onset and a high recurrence rate [1]. The standard treatment for small bowel hemangioma is surgical resection, which is both invasive and costly [2]. Recently, endoscopic injection sclerotherapy, typically used for esophageal varices, has been increasingly applied to treat gastrointestinal vascular lesions, including small bowel hemangioma [3].
Unexpectedly detected appendiceal perforation during endoscopic direct appendicitis therapy despite negative preoperative computed tomography imaging
Authors: Jun Cai, Yanli Wang, Silin Huang, Suhuan Liao, Jianzhen Ren, Yitian Guo, Nan Liu
Journal: Endoscopy (2024)

Endoscopic direct therapy, such as endoscopic direct appendicitis therapy (EDAT) and endoscopic direct diverticulitis therapy (EDDT), are now the preferred treatments for acute uncomplicated appendicitis and diverticulitis [1] [2]. EDAT stands out for its minimal invasiveness, facilitating real-time observation and targeted treatment, while also delivering high definition imaging that enhances diagnostic accuracy [3]. We report a case of appendiceal perforation that was adeptly diagnosed through direct visualization using a 9-Fr cholangioscope (EyeMax; Micro-Tech, Nanjing, China) ([Video 1]).
Development of an asthma health-care burden score as a measure of severity and predictor of remission in SARP III and U-BIOPRED: results from two major longitudinal asthma cohorts
Authors: Joe G Zein, Nazanin Zounemat-Kerman, Ian M Adcock, Bo Hu, Amy Attaway, Mario Castro, Sven-Erik Dahlén, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Benjamin Gaston, Annette T Hastie, Elliot Israel, Nizar N Jarjour, Bruce D Levy, David T Mauger, Wendy Moore, Michael C Peters, Kaharu Sumino, Elizabeth Townsend, Prescott Woodruff, Victor E Ortega, Sally E Wenzel, Deborah A Meyers, Kian Fan Chung, Eugene R Bleecker
Journal: The Lancet Respiratory Medicine (2024)