tbuckley/cabot-search huggingface dataset:
Relationship between survival and prognostic factors in breast cancer (BC): A single-center experience.
Authors: E. A. Cantor Rizo, P. Cabrera, L. A. Moreno Moreno, J. I. Godoy, C. Trillos, M. Ibañez, G. Hernandez
Journal: Journal of Clinical Oncology (2010)

e12062 Background: In Colombia BC constitutes, after cervix, the second most prevalent cancer location in women and is the first cause of death from cancer in women. There is no local data on the 5-year survival of BC patients in Colombia. It is necessary to define the prognostic factors that have an impact in survival. Methods: Open retrospective cohort study with survival analysis that includes the prognostic factors age, stage at diagnosis, tumor differentiation, metastasis at diagnosis (MaD), metastasis during study period, number of metastasis sites, HER2, axillary nodes, number of affected nodes, estrogenic (ER) and progesterone receptors, treatment with trastuzumab, and hormone therapy. The statistical analysis included Kaplan-Meier test, evaluating survival in relationship with the prognosis variables. Survival distribution was measured by quartiles, and multivariate analyses were performed using the Cox regression. Results: 171 clinical records of the women diagnosed with BC between 2003 and 2008 were reviewed. 50 subjects were <50 years old (29.8%) and 129 (70.2%) were ≥50 years old. The most frequent type of cancer (84.2%) was infiltrative ductal carcinoma, the most frequent stage was IIA (22.8%), 57.9% of patients were in advanced stage (IIB, IIIA, IIIB, IV), 4.7% had MaD, 12.9% positive for HER2, 56.1% had ER+, 63% had hormone therapy, and 9.9% trastuzumab. During the time of study 23 patients died (13.4%). The presence of estrogen receptors correlates with a longer survival (p=0.015). Patients with affected axillary lymph nodes had a lower survival than those with negative nodes (p= 0.012); Patients with MaD had a significantly shorter survival than those without (p=0.000). Survival was also longer for patients who did not develop metastases (p=0.000). On multivariate analyses, the risk factor most strongly associated to the outcome (death) was the presence of MaD (Table). Conclusions: The factors related with most risk of mortality in our study were the presence of MaD as risk factor and the ER+ as a protective factor. Variable HR P (95% CI) MaD 6.013 0.01 (2.069, 17.477) ER 5.241 0.003 (1.739, 15.794) No. of metastasis sites 94.325 0.000 (18.903, 470.679) Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Janssen-Cilag
Abstract 5131: Prediction of Silent Ischemic Lesions After Carotid Artery Stenting Using Integrated Backscatter Ultrasound and Magnetic Resonance Imaging
Authors: Kiyofumi Yamada, Masanori Kawasaki, Shinichi Yoshimura, Yukiko Enomoto, Takahiko Asano, Shinya Minatoguchi, Toru Iwama
Journal: Circulation (2009)

Background: The purpose of this study was to determine whether integrated backscatter (IBS) ultrasound and black-blood magnetic resonance imaging (BB-MRI) can predict the risk of cerebral embolism after carotid artery stenting (CAS). Methods: We performed quantitative analysis of plaque characteristics in carotid arteries using IBS ultrasound (SONOS 7500) and BB-MRI before CAS in 50 patients. We measured IBS values and the signal intensity ratio (SIR) of carotid plaques to that of adjacent sternocleidomastoid muscle from T1-weighted images. We performed diffusion-weighted MRI of the brain before and after CAS. Results: In the patient group that was positive (n =19) for newly appearing ipsilateral silent ischemic lesions (NISIL), relative lipid and intra-plaque hemorrhage area (%LHA) evaluated by IBS analysis (60.2±23.4% and 35.3±19.2%, p&lt;0.001) and SIR (1.40±0.19 and 1.18±0.25, p&lt;0.01) in most stenotic lesions were higher than in the NISIL-negative group (n =31). From the analysis of ROC curves, 50% of the %LHA and an SIR of 1.25 were the most reliable cutoff values for predicting NISIL with the sensitivity of 68% and the specificity of 87% in the IBS analysis and 84% and 68% in the BB-MRI analysis. In multivariate logistic regression analysis, the independent predictors of NISIL were SIR (p = 0.03), the serum CRP level (p = 0.04) and the %LHA (p = 0.05). Conclusions: Quantitative tissue characterization of carotid plaques using IBS ultrasound and BB-MRI was useful to predict NISIL after CAS. It is recommended that plaque components be evaluated by SIR or IBS before CAS, and carotid endarterectomy should be selected to prevent distal embolism when the %LHA is &gt; 50% or the SIR is &gt; 1.25.
Carpal Tunnel Syndrome as a Herald of Autoimmune Rheumatic Disorders
Authors: Badal Pal
Journal: Journal of the Royal Society of Medicine (1997)

In six patients aged 59–71 years carpal tunnel syndrome, seemingly idiopathic, was followed by connective tissue disorders, in most cases autoimmune in nature. Patients with idiopathic carpal tunnel syndrome may therefore require long-term follow-up, if inflammatory rheumatic conditions are not to be missed.
Psychotropic drugs, summer heat and humidity, and hyperpyrexia: a danger restated
Authors: S C Mann, W P Boger
Journal: American Journal of Psychiatry (1978)

The authors note an apparent unawareness of, as well as a paucity of recent literature pertaining to, hyperpyrexia as a complication of psychotropic drug treatment. They report a case of hyperpyrexia in a patient receiving psychotropic agents during a summer heat wave; massive muscle destruction (rhabdomyolysis) with myoglobinuria and acute renal failure make this case of particular interest. Causative mechanisms, preventive measures, and the benefits of prompt recognition and treatment of this condition are discussed.
Abstract 17068: IGFBP-1 Increases Endothelial Nitric Oxide via PI-3-K Activation and Rescues Vascular Function in Murine Models of Endothelial Dysfunction
Authors: Adil Rajwani, Jessica Surr, Amir Aziz, Nadira Yuldasheva, Karen Porter, Hema Viswambharan, Helen Imrie, Matthew Gage, Vivienne Ezzat, Mark T Kearney, Stephen Wheatcroft
Journal: Circulation (2010)

Background: Insulin resistant individuals, who are at elevated CV risk, have reduced concentrations of the carrier protein Insulin-like Growth Factor Binding Protein-1 (IGFBP-1). In obese mice with...
Recognition of depression and anxiety in primary care
Authors: A. House, D. Kessler, D. P. Gray, K. Lloyd, G. Lewis
Journal: BMJ (1999)

# General practitioners in study seemed to agree with commentary writer {#article-title-2} EDITOR—Kessler et al assessed the ability of general practitioners to diagnose depression and anxiety as defined by the general health questionnaire (GHQ-12).1 Unfortunately, they have miscalculated their results; from their data, the general practitioners had a sensitivity of 36% and a specificity of 91%. These figures suggest that the participating general practitioners—at least in their day to day practice—shared Heath's opinion in her commentary.1 Most patients with a score >3 on the general health questionnaire do not have a diagnosable psychiatric condition. 1. 1.↵1. Kessler D, 2. Lloyd K, 3. Lewis G, 4. Gray DP . Cross sectional study of symptom attribution and recognition of depression and anxiety in primary care [with commentary by I Heath]. BMJ 1999; 318: 436–440. [OpenUrl][1][Abstract/FREE Full Text][2] # Authors' reply {#article-title-4} EDITOR—Our paper had a hostile commentary from Heath. She ignored the substance … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DKessler%26rft.auinit1%253DD.%26rft.volume%253D318%26rft.issue%253D7181%26rft.spage%253D436%26rft.epage%253D440%26rft.atitle%253DCross%2Bsectional%2Bstudy%2Bof%2Bsymptom%2Battribution%2Band%2Brecognition%2Bof%2Bdepression%2Band%2Banxiety%2Bin%2Bprimary%2Bcare%2B%2595%2BCommentary%253A%2BThere%2Bmust%2Bbe%2Blimits%2Bto%2Bthe%2Bmedicalisation%2Bof%2Bhuman%2Bdistress%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fbmj.318.7181.436%26rft_id%253Dinfo%253Apmid%252F9974461%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=bmj&resid=318/7181/436&atom=%2Fbmj%2F319%2F7204%2F254.3.atom
Timing of the Most Recent Device Procedure Influences the Clinical Outcome of Lead-Associated Endocarditis
Authors: Arnold J. Greenspon, Jordan M. Prutkin, Muhammad R. Sohail, Holenarasipur R. Vikram, Larry M. Baddour, Stephan B. Danik, James Peacock, Carlos Falces, Jose M. Miro, Elisabeth Blank, Christoph Naber, Roger G. Carrillo, Chi-Hong Tseng, Daniel Z. Uslan
Journal: Journal of the American College of Cardiology (2012)
Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells
Authors: N Debili, JM Masse, A Katz, J Guichard, J Breton-Gorius, W Vainchenker
Journal: Blood (1993)
Abstract 235: More Than Doubled Survival in Out-of-Hospital Cardiac Arrest After the Implementation of a Dual Dispatch System is Attributable to Pre-Hospital Rather Than In-Hospital Factors
Authors: Per Nordberg, Jacob Hollenberg, Mårten Rosenqvist, Johan Herlitz, Martin Jonsson, Hans Järnbert-Pettersson, Sune Forsberg, Tobias Dahlqvist, Mattias Ringh, Leif Svensson
Journal: Circulation (2013)

Introduction: In 2005, a dual dispatch system using fire fighters as first responders in addition to emergency medical service in out-of-hospital cardiac arrest (OHCA) was implemented in Stockholm, Sweden. A pilot study from 2006 showed doubled survival in witnessed OHCA compared to historical controls. The aim of this study was to determine the short and long term impact of the intervention and to investigate the additional effect on survival of in-hospital interventions such as therapeutic hypothermia and acute catheterization. Methods and Results: OHCA from 2004 (historical controls, n=620) and 2006-2009 (intervention period, n=2863). Fire fighters performed CPR in 90 % of the patients. They were first on scene and connected an automated external defibrillator in 41% of the cases. The median time from dispatch to arrival of first responder shortened from 7.7 minutes in the control period to 6.7 minutes (p&lt;0.001). Survival to 1 month improved from 3.9 % to 7.4 % (p=0.002). Logistic regression (adjustments for: sex, age, place, etiology, witnessed status, bystander-CPR, first rhythm) gave adjusted OR 2.7 (CI 1.5-4.6). Survival to 3 years increased from 2.4% to 6.2% (p&lt;0.001), adjusted OR 3.5 (CI 1.8-7.0). In the logistic regression analysis including in-hospital factors we found no additional outcome benefit of therapeutic hypothermia, adjusted OR 1.5 (CI 0.7-3.2) and acute catheterization/thrombolysis, adjusted OR 1.7 (CI 0.9-3.1). Conclusions: The implementation of a dual dispatch system using fire-fighters has significantly increased survival after 1 month and 3 year in OHCA. Only pre-hospital factors had an impact on outcome.
Abstract 20370: Fibrinolytic Regulation by CD39: Transcriptional Attenuation of Hypoxic-PAI-1 Induction Through c-Myc/Hif-1{alpha} Competition
Authors: Hui Liao, Scott Visovatti, Amy E Baek, David J Pinsky
Journal: Circulation (2010)

CD39 is an ectonucleotidase that regulates platelet function by phosphohydrolyzing ATP and ADP. In the setting of ischemic injury, CD39 may also maintain blood fluidity by promoting fibrinolysis. P...
Virus-host interactions and the unusual age and sex distribution of human cases of influenza A(H7N9) in China, April 2013
Authors: D M Skowronski, N Z Janjua, T L Kwindt, G De Serres
Journal: Eurosurveillance (2013)

Preview this article: Virus-host interactions and the unusual age and sex distribution of human cases of influenza A(H7N9) in China, April 2013, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/18/17/art20465-en-1.gif
A randomized Southwest Oncology Group study comparing dexamethasone (D) to lenalidomide + dexamethasone (LD) as treatment of newly-diagnosed multiple myeloma (NDMM): Impact of cytogenetic abnormalities on efficacy of LD, and updated overall study results
Authors: J. A. Zonder, J. J. Crowley, V. Bolejack, M. A. Hussein, D. F. Moore, B. F. Whittenberger, M. H. Abidi, B. G. Durie, B. Barlogie
Journal: Journal of Clinical Oncology (2008)

8521 Background: We recently reported superior 1-yr prog. free survival (PFS) for pts with NDMM treated with LD vs D alone. High-risk cytogenetic abnormalities (HRCA) confer poor prognosis with standard therapies, including high dose melphalan. It is unknown if pts on LD with HRCA will also have inferior results. We prospectively examined the impact of abnormal karyotype (AK) and HRCA (defined as deletion of chromosomes 13 and/or 17 by FISH) on 1-yr PFS and overall survival (OS), as well as updated overall study results. Methods: 198 pts with NDMM were randomized to L 25 mg/day (28 of 35 days x 3 cycles, then 21 of 28 days as maintenance) + D (40 mg d1–4, 9–12, 17–20 induction; d1–4, 15–18 maintenance) or D (same induction and maintenance schedules) + placebo. Cross-over to LD was allowed for progressive disease on D. Aspirin 325 mg/d was mandated. Pts had a baseline bone marrow aspirate for karyotypic analysis and FISH for deletions of chromosomes 13 and 17. The response rate (RR) by IMWG criteria, PFS, and OS of pts in each study arm were updated. The impact of AK and HRCA by FISH on PFS and OS was assessed by log-rank analysis. Results: Informative baseline karyotypes and FISH results were available for 103 and 80 pts, respectively. AK were seen in 10/52 samples from pts on D, and 11/51 on LD. Twelve of 45 samples from pts on D and 8/35 on LD had HRCA. For pts on LD without AK, 1-yr PFS and OS were 86% and 97% respectively, vs 55% (p=0.13) and 82% (p=0.02) in pts with AK. Pts on D alone with AK had 1-yr PFS and OS of 33% and 77% (p=NS). 1-yr PFS and OS for pts on LD were both 100% with HRCA vs 73% and 92% without HRCA (p=NS). Conclusions: In this sub-group analysis, pts with NDMM on LD with AK had lower PFS and OS compared to those without AK. HRCA as defined in this study did not seem to account for this difference, but sample size limited the statistical power of the analysis. Pts with AK treated with LD had higher PFS and OS compared to those on D alone. Further characterization of observed karyotypic and FISH abnormalities, as well as extended follow-up for PFS, OS, and RR (including ≥VGPR rates) for S0232 will be presented at ASCO. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Celgene, Millennium Celgene, Millennium
Abstract 9157: Rightward Shift Of V-slope In Cardiopulmonary Exercise Testing (CPX) As A Marker Of Increased Exercise Tolerance
Authors: Hirotaka Nishijima, Kazuo Kondou, Kazuya Yonezawa
Journal: Circulation (2012)

INTRODUCTION: A new method to detect change in exercise tolerance is presented. It is based on our observation that rightward shift of the v-slope relative to the R=1 line, due to exercise-induced increased tissue CO2 store, correlated with increased anaerobic threshold (AT) and VO2 max. METHODS: The records of 166 patients who underwent CPX during cardiac rehabilitation (CR, 3-6 months) were retrospectively reviewed. The mean age was 64(SD:11) with 143 males and 23 females. The underlying heart disease was ischemic. CPX using upright bicycle was submaximal, mostly terminated with the appearance of AT. CR was hospital (mean 3.1 visits/month) and home based. The mean time between the 1st and 2nd tests was 135(29) days. AT was determined blind by an experienced evaluator. Pre and post CR v-slope data sets were plotted together. Exercise data points in the pre-post shared range were selected. Each v-slope was regressed for the quadratic equation. At the y-axis mid-point (line A-B) the distance between R=1 and each regression line was read off (Rightward Shift: RS, ml/min VO2). RESULTS: The changes in basic exercise variables were as follows: highest HR (b/min), from 111(22) to 117(18) (ns); highest VO2 (ml/min/kg), 14.6(3.5) to 17.0(4.1) (p&lt;0.001), and body weight (kg), 66.1(10.9) to 66.7 (10.9)(p&lt;0.006). AT (ml/min VO2) increased from 670(217) to 721(251) (p&lt;0.0004). RS increased from 35(61) to 49(60) (p&lt;0.0003). Also, the baseline RS significantly correlated with AT (r=0.68, p&lt;0.001). CONCLUSION: A completely new method to detect changes in exercise tolerance is described. It calculates a shift in 2 v-slopes. At baseline the degree of rightward shift was associated with an increase in AT. After cardiac rehabilitation v-slope shifted further rightwards as AT increased. The shift method was as sensitive as AT to detect changes in exercise tolerance. There is no need for maximal exercise or an evaluator to read a v-slope. The procedure can be automated.
HL-A antigens and disease
Authors: G. Nicholas Rogentine, R. A. Yankee, J. J. Gart, J. Nam, R. J. Trapani
Journal: Journal of Clinical Investigation (1972)

50 Caucasian children with acute lymphocytic leukemia (ALL) and 219 members of their families have been genotyped for 15 antigens of the HL-A system. The antigen and gene frequencies for HL-A2 were significantly higher in the patient population than in a 200 member normal Caucasian panel. No other antigen frequencies were significantly elevated. All antigens typed for were found in the patients. No antigen gain or loss was detected in the leukemic cells.
Abstract 3236: Prevalence and Significance of Incidental Findings Detected on Non-Contrast Computed Tomography of the Chest and Abdomen in Asymptomatic Subjects: The Framingham Heart Study
Authors: Udo Hoffmann, Joe Massaro, Joanne M Murabito, Caroline S Fox, Christopher J O'Donnell
Journal: Circulation (2008)

Background: The prevalence and clinical significance of non-coronary incidental findings (IF) detected on non-contrast CT of the chest and abdomen in asymptomatic subjects and associated subject bu...
Abstract 3274: Application of Guidelines into Practice for Sudden Cardiac Arrest through Implementation of a Novel Protocol
Authors: Brian M Ramza, Andrew C Kao, William C Daniel
Journal: Circulation (2007)

Introduction: Specific guidelines exist for identification and treatment of patients at risk for sudden cardiac arrest (SCA); however, little data exist describing how often these patients are accurately identified and appropriately treated. The objectives of this prospective, single center study were to compare the effect of an electronic reminder and protocol on the ability to recognize patients at risk for SCA and the application of the guidelines for therapy. Methods: In this study an electronic reminder and protocol were used at one site, the main clinic (MC), compared to all other sites, regional clinics (RC). The protocol was based on current AHA/ACC and CMS guidelines with practice specific quality measures. The protocol included optimal medical treatment prior to ICD, temporary and absolute exclusions for ICD therapy. MC staff was trained to use a new process designed to better identify patients at risk for SCA. This included screening forms, a standardized patient education video, and a patented reminder tool for EMR systems to continue tracking patients that did not immediately qualify for ICD therapy. An independent review of medical charts for all patients visiting the MC and RC over a 2-month period was then conducted to evaluate the clinics ability to identify patients at risk for SCA and apply the current guidelines for appropriate care. Patients were followed for 6 months. Results: Table 1 . Recognition of patients at risk for SCA improved significantly from 70% at RC to 93% at MC. Application of the guidelines into practice as measured ultimately by optimal medical treatment combined with ICD implantation was significantly improved as well. Conclusions: Recognition rates of patients at risk for SCA and subsequent adoption of guideline-based therapy including optimal medical therapy and ICD implantation was significantly greater with the use of this novel protocol combining AHA/ACC and CMS guidelines with practice specific quality measures. Table 1
Olaparib in Platinum-Sensitive Ovarian Cancer
Authors: Daisuke Kaji, Yuji Miura, Toshimi Takano
Journal: New England Journal of Medicine (2012)

To the Editor: Ledermann et al. (April 12 issue)1 report that olaparib as maintenance therapy significantly improved progression-free survival among patients with platinum-sensitive relapsed ovarian cancer who had a response to the most recent platinum-based chemotherapy. In this study, the benefit of olaparib was consistently shown regardless of the BRCA mutational status. Another study showed that the efficacy of olaparib depended on platinum sensitivity even among patients with BRCA-mutated ovarian cancer.2 These studies suggest that platinum sensitivity is more important to predict sensitivity of poly(adenosine diphosphate–ribose) polymerase (PARP) inhibitors than the mutational status of BRCA1 and BRCA2 alone. Many genes other than BRCA are involved in platinum-induced DNA damage repair and related to platinum sensitivity.3,4 We believe that such genes, not only BRCA, should be analyzed in clinical trials of PARP inhibitors.
Abstract 12043: The Impact of Vascular Access Site on In-Hospital and One-Year Clinical Outcomes in Patients with Acute Myocardial Infarction: Results From the Korea Acute Myocardial Infarction Registry
Authors: Kwang S Cha, Hye W Lee, Mi J Yang, Sung G An, Jun-Hyok Oh, Jung H Choi, Min S Ahn, Han C Lee, Taek J Hong, Jeong S Kim, Yong H Park, Jun Kim, June H Kim, Kook J Chun, Jaeseon Kim, Myung H Jeong, Youngkeun Ahn, Shung C Chae, Young J Kim
Journal: Circulation (2011)

Background: Bleeding has recently emerged as a predictor of early and late mortality after percutaneous coronary intervention (PCI). Full anticoagulation and multiple antiplatelets increase the ris...
20 Years After AIDS Emerges, HIV's Complexities Still Loom Large
Authors: J Stephenson
Journal: JAMA (2001)

CHICAGO—As the HIV/AIDS epidemic approaches the 20th anniversary of the first mysterious reports of people with the syndrome, researchers and clinicians continue to grapple with the complexities of the virus. Those complexities were readily evident here at the 8th Annual Retrovirus Conference, where some 3000 participants gathered to hear reports of the latest findings. Although at least 15 drugs have been approved to treat HIV infection and experimental therapies are in the developmental pipeline, new reports of rising resistance rates—as well as a better appreciation of potential adverse effects—underscore the urgent need for new antiretroviral agents. At the same time, discoveries about the molecular underpinnings of HIV and the genetic makeup of people infected with the virus are providing fresh insights into variations in risk for complications involving anti-HIV drugs and for disease associated with HCV coinfection.