tbuckley/cabot-search huggingface dataset:
Health Sciences and Services. A Guide to Information Sources.
Authors: Lois F. Lunin
Journal: Annals of Internal Medicine (1980)

The health care field in the United States today is a multibillion dollar industry.A guide to the many and varied information sources concerning health sciences and services could be expected to fill a widely felt need.Lois Lunin states in her introduction that this book is intended to aid both those unfamiliar with the field and those already working in it, by providing "a comprehensive list of the major publications and facilities available within each of a large number of specific biomedi- cal areas."The work is organized into fifteen parts, with major parts being further subdivided into sections.For example, there are sections for each of the basic health sciences and each of the clinical sciences, as well as sections covering dentistry, public health, hospitals and nursing homes, and the communication of health information.Other sections concern nursing, veterinary medicine, health insurance, pharmacy and the pharmaceutical industry, core collections, and a brief consider- ation of allied health sciences and services.The arrangement within each section is standard throughout the book.A definition of the topic is followed by a list of publications.These may include suggestions for background reading, guides, dictionaries, handbooks, directories, title alerting and index/abstract publications, bibliog- raphies, serials, or audiovisual and nonconven- tional materials (usually microforms).Information on data bases is given next, followed by a list of organizations, which may include one or more of the following: information or referral services; academies, societies and similar institutions; federal government sources; and libraries and special collections.Most of the information sources are of United States origin, although a few British and Canadian items have been included.Many of the entries are well annotated.
Modeling MLN8237, an aurora kinase a inhibitor, with irinotecan (IRN) and temozolomide (TMZ) in neuroblastoma (NB).
Authors: E. G. Lipsitz, V. Nguyen, H. Zhao, J. Ecsedy, J. M. Maris, P. C. Adamson, Y. P. Mosse
Journal: Journal of Clinical Oncology (2010)

10593 Background: MLN8237 is a selective Aurora kinase A inhibitor undergoing early phase clinical evaluation, and has demonstrated significant activity in NB xenograft models (Maris et al, PBC 2010). To determine how MLN8237 could potentially be integrated into a multiagent regimen currently utilized for children with relapsed/refractory NB, we evaluated the interaction of MLN8237 with IRN and TMZ, a combination shown to have activity against refractory NB. Methods: Four NB cell lines (Kelly, SKNBe2, NB1643, and EbC1) were treated with MLN8237 in combination with IRN or TMZ. Following a 120-hour drug exposure, cytotoxicity was assessed using the sulforhodamine B assay. The combination index (CI) of Chou Talalay was used to characterize the interaction of MLN8237 with IRN or TMZ. Two NB cell lines (NB1691 and CHLA79), previously shown to be less sensitive to MLN8237 in vivo, were selected for xenograft efficacy studies. These four-arm studies consisted of placebo, IRN/TEM for 5 days, MLN8237 at 30 mg/kg once daily for 7 days, and combination of MLN8237/IRN/TEM at the same doses. To model the human clinical dosing schedule of single agent MLN8237, dosing was cycled every other week, with a total of 3 cycles provided. Data were analyzed by a mixed effects linear model and Kaplan-Meier method using the log-rank test. Results: The median (range) IC50 of single agent MLN8237 or IRN across all cell lines was 0.02 (0.005-0.05) μM and 0.95 (0.4-1.7) μM, respectively, whereas the TMZ IC50 was > 250 μM. The combination of MLN8237 with IRN or TMZ resulted in additive to synergistic interactions in all cell lines, with a median (range) CI of 0.8 (0.5-0.9) for MLN8237+IRN, and 0.4 (0.3-1) for MLN8237+TMZ. In the NB1691 xenograft, both MLN8237 alone and IRN combined with TMZ slowed tumor growth compared to vehicle-treated animals (p < 0.0001), and prolonged survival (p < 0.0001). The combination of MLN8237, IRN and TMZ prevented tumor growth and significantly prolonged survival relative to the MLN8237 or IRN/TMZ arms (p < 0.0001) with no overt toxicity. Testing in the CHLA79 xenograft model is ongoing, as is CI of these lines in vitro. Conclusions: These data support the development of MLN8237+IRN+TMZ for patients with neuroblastoma. No significant financial relationships to disclose.
A Laboratory Handbook for Dietetics.
Authors: Mary Swartz Rose
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
... and that thick ears signify greater wealth
Authors: P.-N. Woo, P.-L. Lip
Journal: BMJ (1996)

EDITOR,—James A Heathcote's cross sectional study of 206 patients, in which he measured the length of the subjects' ears, leads him to conclude that older men have larger ears.1 This observation may confirm ancient beliefs. In particular, it is believed in Chinese culture (and also evident in Chinese literature and traditional grandmothers' tales) that studying a person's facial features may reveal a …
High frequency of loss of heterozygosity on chromosomes 1p, 4p, 4q, 9p, 13q, and 17p in hepatocellular carcinomas from Australia and South Africa
Authors: N. I. Herath, M. C. Kew, J. P. Young, L. W. Powell, B. A. Leggett, G. A. Macdonald
Journal: Hepatology (2001)
Complexities in responding to the Ebola epidemic
Authors: J. P. Woodall
Journal: BMJ (2015)

I disagree with Gericke in his editorial on Ebola and ethics.1 Because there was no vaccine, health workers at the front line were desperate for an effective response, so the focus on specific treatments was highly appropriate. If an effective treatment had been found, people would have seen hospitals as places to be cured rather than …
Abstract 776: Protein Disulfide Isomerase Is Involved In Redox Regulation Of Nitric Oxide Output During Laminar Shear Stress In Endothelial Cells
Authors: Denise C Fernandes, Celio X Santos, Hanjoong Jo, Francisco R Laurindo
Journal: Circulation (2007)

While anti-atherogenic effects of sustained laminar shear (LS) involve NO release from eNOS, increases in LS trigger transient superoxide production via NADPH oxidase. Recently, we showed that NADPH oxidase undergoes thiol-dependent regulation by the thioredoxin superfamily chaperone Protein Disulfide Isomerase (PDI). PDI is known to promote NO internalization via trans-nitrosation reactions. We hypothesized that PDI-dependent support of NADPH oxidase activity affects NO output during sustained LS. Cultured rabbit aortic endothelial cells (RAEC) submitted to LS (15 dynes/cm 2 ) in a cone-plate system for 18h exhibited (vs. static controls): Decreased (~50%) superoxide production (HPLC analysis of DHE oxidation); Decreased (~20%) NADPH-triggered hydrogen peroxide production in membrane fraction (Amplex Red assay); Decreased mRNA expression of Nox1 (67%) and Nox4 (45%) (real-time QPCR); Increased eNOS expression (~50%, western blot) and nitrite levels in culture medium (Δ = 7.1±2.5[SD] μM, NO Analyzer and Griess reaction); Decrease in total and membrane fraction PDI protein expression (~20%) without changes in membrane fraction/total ratio of PDI. RAEC were transfected with c-myc -tagged plasmid coding for wild-type (WT) PDI or PDI mutated in 4 thioredoxin-motif cysteine residues. Forced expression (2-fold) of mutated but not WT PDI led to increase in nitrite output after LS (18h) (Δmutated = 17.2±3.3 μM vs. ΔWT = 7.0±1.9 μM, n=3, p&lt;0.02). Confocal microscopy indicated similar subcellular localization between WT and mutated PDI. PDI co-imunoprecipitated with p22phox NADPH oxidase subunit, but not with eNOS or caveolin-1, either in static condition or after LS. Fractionation studies in sucrose gradients showed that PDI is distributed throughout several fractions in static conditions, including caveolin-1-enriched fractions, but migrates to higher-density fractions, not containing caveolin-1, during sustained LS. These results suggest that PDI is involved in regulation of NO output during LS via its effects on NADPH oxidase activity.
Epidemic Encephalitis (Encephalo-Myelitis).
Authors: Leo Melville Crafts
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blades' Surgical Diseases of the Chest.
Authors: Brian Brewer Blades, Donald Brian Effler
Journal: Annals of Internal Medicine (1979)

And now comes the fourth edition of Blades' Surgical Diseases of the Chest. Thoracic surgery has developed so much in the post-World War II years that an 839-page book on this subject may be considered as possibly basic when compared with current textbooks twice its size. To quote the preface, the question is whether this volume is of value to the practicing surgeon, resident and medical student? This book has been almost completely rewritten with mostly new authors. The editor has appropriately dedicated this new edition to the original editor, Dr Brian Brewer Blades, for his pioneering contributions and leadership in thoracic surgery. The first chapter titled Medical Ethics and Organization is written by an eminent authority, Dr C. Rollins Hanlon, director of the prestigious American College of Surgeons. With the current great lay and judicial involvement in medical ethics and the delivery of medical care, the complete surgeon must be thoroughly grounded in these complex problems. An understanding of ghost surgery, unnec¬ essary surgery, overcharging, etc,
Blood Pressure Variability.
Authors: S Grosch, A Saint-Remy, J M Krzesinski
Journal: Annals of Internal Medicine (1980)

Blood pressure variability is a physiological phenomenon influenced by many internal and external factors. This variability could be also influenced by pathological conditions such as arterial hypertension. Two forms must be mainly distinguished: the blood pressure variability at long but also short-term. The latter could only be studied by continuous recordings. From the initial invasive intraarterial approach, it can nowadays be explored by a non invasive system of beat to beat recordings using the infrared photo plethysmography (the FINAPRES system). In this paper, some important questions will be treated such as the interest of measuring blood pressure variability, its cardiovascular prognosis and how therapeutic tools can be applied when it is increased?
Biodegradable nano-films for capture and non-invasive release of circulating tumor cells
Authors: Wei Li, Eduardo Reátegui, Myoung-Hwan Park, Steven Castleberry, Jason Z. Deng, Bryan Hsu, Sarah Mayner, Anne E. Jensen, Lecia V. Sequist, Shyamala Maheswaran, Daniel A. Haber, Mehmet Toner, Shannon L. Stott, Paula T. Hammond
Journal: Biomaterials (2015)
Abstract 11933: The Impact of the Eighth Joint National Committee Guidelines for the Treatment of High Blood Pressure on an Older US Cohort: The Atherosclerosis Risk in Communities Study
Authors: Michael D Miedema, Faye L Lopez, Michael J Blaha, Salim S Virani, Josef Coresh, Christie M Ballantyne, Aaron R Folsom
Journal: Circulation (2014)

Introduction:  The Eighth Joint National Committee (JNC 8) recently released new guidelines for the treatment of high blood pressure, recommending less aggressive treatment goals than the prior seventh Joint National Committee (JNC7) recommendations for individuals with diabetes or chronic kidney disease (CKD) as well as individuals aged ≤ 60 years. The potential impact of these changes on the older US population requires further analysis.   Methods:  We performed a cross-sectional analysis of black and white participants from 4 communities in the Atherosclerosis Risk in Communities study who participated in the 5th study visit (2011-2013). Sitting blood pressure was obtained 3 times after a 5-minute rest and an average of the 3 readings was used. The use of antihypertensive medications was verified by reviewing medications brought to the visit. Blood pressure control was defined using both the previous JNC 7 goals (   Results:  In our sample of 6,088 participants (mean age 75.6 years [range 66-90], 58.4% female, 23.2% African American), 75.0% were taking antihypertensive medications and 54.9% had either diabetes or CKD. Rates of control of hypertension according to JNC 7 and JNC 8 recommendations are shown in the table. Black individuals were less likely to have controlled blood pressure by either criterion although the increase in rates of control using JNC8 compared to JNC7 was similar between races. An analysis according to sex showed similar findings in men and women.   Conclusion:  In a US cohort of older white and black individuals with a high prevalence of diabetes or CKD, approximately 1 in 6 individuals who previously would be considered to have uncontrolled blood pressure are now within goals established by the new JNC 8 guidelines.
Lymphomas in RA patients treated with TNF-blockers. Cases found in a post-marketing surveillance in Sweden
Authors: N Feltelius, P Geborek, E Baecklund, C Sundstrom, L Bertilsson, L Jacobsson, S Lindblad, J Lysholm, Solbritt Rantapää-Dahlqvist, T Saxne, L Klarskog
Journal: Annals of the Rheumatic Diseases (2004)

Lymphomas in RA patients treated with TNF-blockers. Cases found in a post-marketing surveillance in Sweden
Abstract 16070: Gender Disparity in the Outcomes and the Rates of Revascularization of Patients With Stable Coronary Artery Disease in the United States
Authors: Angelika Jovin, Peter Danyi, Hem L Bhardwaj, Ranjith Shetty, Mitesh S Amin, Ion S Jovin
Journal: Circulation (2010)

Background: There is a gender disparity in the outcomes and therapies of patients with myocardial infarction. Female gender is associated with poorer outcomes and lower rates of revascularization. However, whether the outcomes and the revascularization rates of women with stable coronary artery disease (CAD) are different from men is not known. Methods: We used the Healthcare Cost and Utilization Project (HCUP) to study national rates for admissions due to CAD as well as the outcomes and the rates of procedures for revascularization therapy with bypass surgery or percutaneous coronary intervention during the year of 2005. Results: Out of a total of 917,478 admissions for coronary atherosclerosis, 333,757 (36%) were women and 583,581 (64%) were men. Women had longer lengths of stay compared to men (3.6 ± 0.1 vs 3.5 ± 0.1 days, respectively; P<0.001) and higher in-hospital mortality rates (0.67 % vs 0.42%; respectively; P<0.01). The proportion of women admitted with a diagnosis of coronary atherosclerosis a...
Rituximab and CODOX-M / IVAC Without Stem Cell Transplantation For Poor Risk Diffuse Large B Cell Lymphoma (IPI3-5) and Burkitts Lymphoma Is Feasible and Gives a High Response Rate: Preliminary Results Of a Phase 2 UK National Cancer Research Institute Trial
Authors: Andrew McMillan, Kirit M Ardeshna, Jo Gambell, Andrew Jack, Amy Kirkwood, Anthony Laurie, Silvia Montoto, Shankaranarayana Paneesha, Simon Rule, Russell Patmore, Ruth Pettengell, Humra Shah, Paul Smith, David Linch
Journal: Blood (2013)
High Prevalence of a Pathological Response to Acetylcholine Testing in Patients With Stable Angina Pectoris and Unobstructed Coronary Arteries
Authors: Peter Ong, Anastasios Athanasiadis, Gabor Borgulya, Heiko Mahrholdt, Juan Carlos Kaski, Udo Sechtem
Journal: Journal of the American College of Cardiology (2012)
Abstract 1267: Intracoronary Administration of Cardiac Stem Cells Improves Cardiac Function in Pigs with Old Infarction
Authors: Roberto Bolli, Hani Jneid, Xian-Liang Tang, Buddhadeb Dawn, Ornella Rimoldi, Federico Mosna, Maria Loredo, Alessandro Gatti, Jan Kajstura, Annarosa Leri, Claudia Bearzi, Ahmed Abdel-Latif, Piero Anversa
Journal: Circulation (2006)
Abstract 16212: Premature Atherosclerosis in Premenopausal Women: Does Cytokine Balance Play a Role?
Authors: Jo-Ann Eastwood, Doris A Taylor, Claudia Zierold, B.Delia Johnson, Barry L Sharaf, Bina Ahmed, Margo Minissian, Chrisandra Shufelt, C. Noel Bairey Merz
Journal: Circulation (2011)

Background: Contributory risk factors to premature coronary atherosclerosis in premenopausal women are poorly understood. Mechanistic insights from animal work suggest that cytokine balance is rela...
Abstract 17082: Hematocrit Significantly Affects the Results of the Verifynow Assay in Patients Receiving Dual Antiplatelet Therapy
Authors: Nikolaos Kakouros, Thomas S Kickler, Katherine Laws, Jeffrey J Rade
Journal: Circulation (2011)

Background: A number of assays have evolved to assess platelet reactivity and identify patients on dual antiplatelet therapy who remain at risk of thrombotic events. The goal of this study was to assess how a number of these assays are affected by clinical and hematological factors. Methods: We prospectively recruited patients with known vascular disease or risk factors presenting for coronary catheterization and assessed platelet reactivity at baseline and after clopidogrel loading using the VerifyNow P2Y12 assay, Platelet Function Analyzer (PFA-100):Collagen/Epinephrine(Col/Epi), PFA-100:Collagen/ADP(Col/ADP), and platelet aggregometry with 5μ M, 10μ M and 20μ M ADP agonists. Univariate and multivariate regression models were developed to identify clinical and laboratory factors affecting the assays. Results: Of 198 patients who entered the study 79 patients were excluded due to intraprocedural use of GPIIb/IIIa antagonists or lack of repeat blood sample. Fifty-five patients underwent coronary intervention. Plasma vonWillebrand factor antigen (vWFAg) levels were a significant univariate predictor of PFA-100:Col/Epi (p=0.002) but not Col/ADP closure times. VerifyNow base and platelet reactivity results (PRU) both prior to and after clopidogrel load had a strong negative correlation with hematocrit (p&lt;0.0001, p=0.0004) as did impedance and light aggregometry. Hematocrit remained the only strong predictor of post-Clopidogrel VerifyNow result in multivariate analysis modeling (p=0.001). Conclusions: Plasma vWFAg levels significantly affect the PFA-100:Col/Epi assay. In contrast to prior small validation studies, performed in normal individuals, we found hematocrit level to have a strong negative correlation with VerifyNow results in this cohort of patients. It is unclear whether the observed correlation is due to truly increased in vivo platelet reactivity in anemic patients or an in vitro phenomenon inherent to the VerifyNow system.
Les rayons ultra-violets et associés en thérapeutique.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hematopoietic mutants identified in a saturation screen of the zebrafish genome
Authors: D Ransom, A Brownlie, P Haffter, J Odenthal, R N Kelsh, M Brand, Makoto Furutani-Seiki, M Granato, M Hammerschmidt, C P Heisenberg, Y J Jiang, D Kane, M Mullins, F vanEden, R Warga, C NussleinVolhard, L Zon
Journal: Blood (1995)
Diagnostics of Diseases of Children.
Authors: Le Grand Kerr
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal