tbuckley/cabot-search huggingface dataset:
New Harvest: Transplanting Body Parts and Reaping the Benefits
Authors: C. D. Keyes, Walter E. Wiest
Journal: Annals of Internal Medicine (1991)

Medical and Ethical Foundations. Four Ethical Concerns. Transplantation and Foundational Biomedical Ethical Values. Beginning and End of Biological Life. Medical and Historical Perspectives. Medical Concerns of Procurement. History of Transplantation and Future Trends. Reproductive and Neurological Transplantation. Reproduction and Transplantation. Brain Tissue Grafting. Psychiatric and Philosophical Perspectives on Self-Identity. Psychological Perspectives on the Process of Organ Transplantation. Sexual Performance Before and After Transplantation. Body and Self-Identity. Religious Perspectives. Introduction to Religious Perspectives. Jewish Perspectives. Christian Perspectives. Legal and Other Perspectives. Legal Aspects of Procurement. Legal Aspects of Allocation. A Word from the Other Players. Conclusion. Reaping the Bene' ts. Index.
Die wichtigsten Vergiftungen: Fortschritte in deren Érkennung und Behandlung.
Authors: Erich Leschke
Journal: JAMA (1933)

The author deplores the fact that a knowledge of toxicology is not more generally in the possession of the medical profession. According to Zangger, 80 per cent of cases of poisoning are not recognized. This book differs from most others on toxicology in that it is not written by a pharmacologist but by a clinician and for clinicians. In Germany, barbital poisoning is most frequently encountered (seventy-seven cases), with morphine next in order (forty-five cases), and compound solution of cresol, adalin, hydrochloric acid and phenobarbital (each about ten cases) accounting for two thirds of all cases of poisoning in a certain series: and most of these suicidal. The exposition of the subject is so thoroughly modern that it is a book well worth having even in a library that boasts any number of books on toxicology.
The Relationship of Certain Focal Infections to General Disease in Infants and Young Children
Authors: Mckim Marriott
Journal: Annals of Internal Medicine (1927)

Article1 July 1927The Relationship of Certain Focal Infections to General Disease in Infants and Young ChildrenMCKIM MARRIOTT, M.D.MCKIM MARRIOTT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring recent years, much evidence has accumulated to emphasize the importance of focal infections in the causation of general disease during infancy and childhood. We have gradually come to realize that certain conditions, which previously have been regarded as nutritional and metabolic in origin, are in reality the result of infection. Certain infections such as those in tonsils and adenoids, middle ear, chest, genito-urinary system, bones and skin, can usually be recognized without much difficulty, by anyone who conducts a systematic search. There are other locations, however, in which infections occur which are not so obvious: for example in the...Bibliography(1) ALDENLYMAN AMHW: Gastro-intestinal Disturbances in Infants as a Result of Obscure Infection in the Mastoid. The Laryngoscope, Aug., 1925. CrossrefGoogle Scholar(2) DU VERNEY , quoted by Troltsch: Lehrbuch der Ohrenheilkunde, 1881, 431. Google Scholar(3) HARTMANN : Die Einwirkung der Otitis Media der Säuglinge auf den Verdauungs-apparat. Zeitschrift fur Ohrenheilkunde, xxxiv, p. i, 1898. Google Scholar(4) RENAUD M: Bulletins et Memoires de la Societé Médicale des Hôpitaux, Paris, xlv, 1326, 1352, 1384. Google Scholar(5) BYFIELD : Section on Systemic Effects of Chronic Infection in the Upper Respiratory Tract. Abt's Pediatrics, Vol. iii, p. 786. Google Scholar(6) FLOYD : Masked Mastoiditis Simulating Alimentary Intoxication (Anhydremia), Archives of Oto-Laryngology, I. 411. Google Scholar(7) BRENNEMAN J: The Abdominal Pain of Throat Infections, Amer. J. Dis. Child., xxii, 493, (Nov.) 1921. Google Scholar(8) CLAUSEN SW: Parenchymatous Nephritis. II. Infection of Paranasal Sinuses as Etiology. Amer. J. Dis. Child., May, 1925, xxix, 587. CrossrefGoogle Scholar(9) CLAUSEN SW: III. The Surface Tension of the Blood Serum, Ibid., xxix, 594. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis, Mo.*From the Department of Pediatrics, Washington University School of Medicine and the St. Louis Children's Hospital.**Read before the American College of Physicians, Cleveland, Ohio, February 24, 1927. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWilliams McKim Marriott 1885–1936 1 July 1927Volume 1, Issue 1Page: 1-8KeywordsChildrenHospital medicineInfantsInfectious diseasesNutritionPediatric infectionsPediatricsSkin infectionsThoraxTonsils ePublished: 1 December 2008 Issue Published: 1 July 1927 PDF downloadLoading ...
The Fundamentals of Pulmonary Tuberculosis and Its Complications, for the Student, the Teacher, and the Practicing Physician.
Authors: Edward William Hayes
Journal: Annals of Internal Medicine (1949)

This book consists of twenty-six chapters prepared by twentyseven physicians. It is characterized by the omission of theoretical and controversial material. Thus, it is a clear and concise statement of well established facts concerning the cause, diagnosis, treatment and prevention of tuberculosis. The disease is presented from the time tubercle bacilli first invade the human body through the earliest detectable pathologic processes and through the various stages of evolution until the body dies from tuberculosis or its complications. The chapter on bacteriology and pathology clearly and concisely presents the various stages in the development of the disease. It is profusely illustrated with microscopic sections, gross specimens and roentgen shadows which they cast. In 40 pages the student and practitioner find all of the essential and practical information necessary on the pathology of tuberculosis. In a chapter entitled, "The Role of the Bronchial Tree in the Pathogenesis of Pulmonary Tuberculosis," such
Virus Diseases and the Cardiovascular System: A Survey.
Authors: Ernest Lyon
Journal: Annals of Internal Medicine (1958)

In the past few years the effects of the many virus diseases on the cardiovascular system have been recognized. Reports of electrocardiographic changes in a number of virus infections, the increasing incidence of nonspecific pericarditis and myocarditis probably of viral origin, and the relationship of rubella ( German measles) in the pregnant mother to congenital heart disease in the child have made the internist and cardiologist aware of the cardiovascular problem in virus diseases. Although much has been written on the subject, pertinent information is difficult to obtain because reports are scattered through many different journals. Dr. Lyon, a well-trained microbiologist and clinician, has done a great service in reviewing a large number of articles in order to include in this volume all the pertinent information on the effect of virus diseases on the heart and blood vessels. In the first part he reviews the present concepts as to how the
Are supplementary services provided during methadone maintenance really cost-effective?
Authors: M K Kraft, A B Rothbard, T R Hadley, A T McLellan, D A Asch
Journal: American Journal of Psychiatry (1997)

Objective: Previous research has suggested that support services supplementing methadone maintenance programs vary in their cost-effectiveness.This study examined the cost-effectiveness of varying levels of supplementary support services to determine whether the relative cost-effectiveness of alternative levels of support is sustained over time.Method: A group of 100 methadone-maintained opiate users were randomly assigned to three treatment groups receiving different levels of support services during a 24-week clinical trial.One group received methadone treatment with a minimum of counseling, the second received methadone plus more intensive counseling, and the third received methadone plus enhanced counseling, medical, and psychosocial services.The results at the end of the trial period have been published elsewhere.This article reports the results of an analysis at a 6-month follow-up.Results: The follow-up analysis reaffirmed the preliminary findings that the methadone plus counseling level provided the most cost-effective implementation of the treatment program.At 12 months, the annual cost per abstinent client was $16,485, $9,804, and $11,818 for the low, intermediate, and high levels of support, respectively.Abstinence rates were highest, but modestly so, for the group receiving the high-intensity, high-cost methadone with enhanced services intervention.Conclusions: This study suggests that large amounts of support to methadone-maintained clients are not cost-effective, but it also demonstrates that moderate amounts of support are better than minimal amounts.As funding for these programs is reduced, these findings suggest a floor below which supplementary support should not fall.
Abstract P113: Correlation between Respiration-related Systolic Arterial Pressure Variability and Amount of Blood Loss during Controlled Hemorrhagic Shock in Rat Model
Authors: Yukio Satoh, Masaru Suzuki, Akiko Shiroshita-Takeshita, Kazuhiko Sekine, Shingo Hori
Journal: Circulation (2009)

Objectives: Practical indicator reflecting circulatory blood volume is needed for the treatment of severe hemorrhagic shock. It has been reported that systolic arterial pressure (SAP) variations allow the assessment of cardiac preload. Thus, we aim to investigate whether respiration-related SAP fluctuation is correlated with the amount of blood loss during controlled hemorrhagic shock.  Methods: Fifteen Wistar male rats (214±9g) were anesthetized with sodium pentobarbital intraperitoneally (1.5 mg/kg). Spontaneous respiration was kept in each animal during the study. The left carotid artery was cannulated to draw blood continuously (0.1 ml/min) to induce hemorrhagic shock. SAP was continuously recorded and analyzed by wavelet transform using PC soft ware (FlucletTM, Dainippon-Sumitomo Pharma Co., Ltd., Osaka, Japan). The power spectra were quantified into high-frequency components (HF: 0.74 –2.00 Hz) reflecting the respiration-related SAP fluctuation. Respiratory movement was recorded by a pressure sensor placed under the body.  Results: During controlled hemorrhagic shock (shed blood volume 0 min: 0 ml, 20 min: 2.0ml, 40 min: 4.0 ml, 60 min: 6.0 ml), SAP and HF were gradually decreased (SAP 0 min: 107±14 mmHg, 20min: 70±9, 40min: 57±11, 60min: 48±9, repeated ANOVA P  Conclusions: During controlled hemorrhagic shock in anesthetized rats, respiration-related SAP fluctuation is well correlated with shed blood volume and SAP. These results may provide a novel possible approach to the non-invasive estimation for blood volume status during hemorrhagic shock.
Combining cytokines of different pathways may improve predictive power for radiation-induced lung toxicity
Authors: L. Wang, A. Ruan, L. Zhao, J. A. Hayman, G. P. Kalemkerian, B. Schneider, M. A. Davis, L. Xu, D. Arenberg, F. Kong
Journal: Journal of Clinical Oncology (2008)

22177 Background: Although Transforming growth factor-beta (TGF-β) is a key player, radiation-induced lung toxicity (RILT) involves numerous cytokines of multiple pathways. We hypothesized that TGF-β combined with cytokines of other pathways such as Interleukin (IL)-1β and Macrophage inflammatory protein (MIP)-1β can predict RILT more accurately. Methods: Eligible subjects included patients with stages I-III non-small cell lung cancer (NSCLC) treated with RT alone or combined chemoradiation. Plasma TGF- β1 and 29 cytokine levels were measured using ELISA and a microsphere-based sandwich immunoassay at pre, 2, and 4 weeks during RT. Logistic Regression was used to test the correlations between cytokine concentration and RILT. Results: There were 25 patients, 6 with and 19 without RILT. Hazard factors TGF-β, MIP-1β, IL-1β, IL-15, GM-CSF, IL-8, IL-12p40, IP-10, IL-12p70, MIP-1α, TGF-α and protective factor IL-1ra were significantly associated with RILT under univariate analysis (X2 all ≥ 3.83, P all ≤ 0.05, -2log likelihood all ≤ 23.73, R2 all ≥ 0.14) at one or more time points. Limited by the case number, the 3 most significant cytokines (TGF-β, MIP-1β and IL-1β) with different functional pathways were chosen for multivariate analysis. The results showed that models using combined cytokines were significantly better than using TGF-β alone at pre and 2 weeks during RT (Table). Conclusions: Multiple cytokines besides TGF-β predict RILT. Models using multiple cytokines are better than using TGF-β alone. Study with a larger sample size is ongoing to validate this encouraging finding. Predictive Power for RILT (P all < 0.05) Time Model ID Cytokines in Model Equation X2 -2log likelihood R2 Pre-RT 1 TGF-β 5.1 22.4 0.18 2 TGF-β, MIP-1β & IL-1β 27.6 0.0 0.66 2 weeks 1 Δ TGF-β 7.3 20.3 0.25 2 Δ TGF-β, MIP-1β & IL-1β 11.4 16.0 0.36 4 weeks 1 Δ TGF-β 12.8 14.8 0.40 2 Δ TGF-β, MIP-1β & IL-1β 14.5 13.0 0.44 Δ TGF-β: relative level to pre-RT No significant financial relationships to disclose.
Diffuse gastric plasmacytoma involvement in multiple myeloma
Authors: Nikolaos Sousos, Efthimia Vlachaki, Kyriaki Anastasiadou, Panagiota Boura, Ioannis Venizelos, Grigoris Chatzimavroudis, Panagiotis Katsinelos
Journal: Endoscopy (2015)

Involvement of the gastrointestinal tract in multiple myeloma is rare. It is an aggressive biological sign and is associated with a poor prognosis [1] [2].
Usefulness of recombinant γ-gliadin 1 for identifying patients with celiac disease and monitoring adherence to a gluten-free diet
Authors: Bharani Srinivasan, Margarete Focke-Tejkl, Milena Weber, Sandra Pahr, Alexandra Baar, Raja Atreya, Markus F. Neurath, Harald Vogelsang, Wolf-Dietrich Huber, Rudolf Valenta
Journal: Journal of Allergy and Clinical Immunology (2015)
Do fetuses feel pain?
Authors: W. Savage, P. D Wall, S. W. Derbyshire
Journal: BMJ (1997)

# Surgical terminations of pregnancy take place under general anaesthesia {#article-title-2} Editor-Peter McCullagh1 and P J Saunders2 link the theoretical possibility that the fetus may feel pain (albeit much earlier than most embryologists and physiologists consider likely) with the procedure of legal abortion. Doctors for a Woman's Choice on Abortion consider this to be unhelpful to women and to the scientific debate. In Britain virtually all surgical terminations of pregnancy take place under general anaesthesia, which will affect the fetus. The question of whether the fetus experiences pain is not an issue as far as abortion is concerned, although those experts in fetomaternal medicine who are operating on the more mature fetus in utero need to consider whether women should have general anaesthesia for these procedures. 1. 1.↵1. McCullagh P . Do fetuses feel pain? BMJ 1997;314:302–3. (25 January.) [OpenUrl][1][PubMed][2] 2. 2.↵1. Saunders PJ . Do fetuses feel pain BMJ 1997;314:303. (25 January.) [OpenUrl][3][PubMed][4] # Definition of pain needs clarification {#article-title-5} Editor-Peter McCullagh1 compounds the confusion of Vivette Glover and Nicholas Fisk over whether fetuses feel pain.2 They show … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DMcCullagh%26rft.auinit1%253DP.%26rft.volume%253D314%26rft.issue%253D7076%26rft.spage%253D302%26rft.epage%253D302%26rft.atitle%253DDo%2Bfetuses%2Bfeel%2Bpain%253F%26rft_id%253Dinfo%253Apmid%252F9022510%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=9022510&link_type=MED&atom=%2Fbmj%2F314%2F7088%2F1201.1.atom [3]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DSaunders%26rft.auinit1%253DP.%2BJ.%26rft.volume%253D314%26rft.issue%253D7076%26rft.spage%253D303%26rft.epage%253D303%26rft.atitle%253DDo%2Bfetuses%2Bfeel%2Bpain%253F%2BWe%2Bshould%2Bgive%2Bthem%2Bthe%2Bbenefit%2Bof%2Bthe%2Bdoubt.%26rft_id%253Dinfo%253Apmid%252F9022511%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [4]: /lookup/external-ref?access_num=9022511&link_type=MED&atom=%2Fbmj%2F314%2F7088%2F1201.1.atom
Holter ECG monitoring of sympathovagal fluctuation during bronchoscopy
Authors: Abdellah Ali, Hiroaki Toba, Shoji Sakiyama, Kazuya Kondo
Journal: European Respiratory Journal (2014)

Background and objectives:  The objective of this study was to evaluate the changes of autonomic nervous activity during bronchoscopic procedures using R-R interval variability from electrocardiograms obtained during diagnostic bronchoscopy. Methods:  Twenty-four patients who underwent bronchoscopy were included. Continuous electrocardiogram was recorded prior to, during, and after the bronchoscopic procedure. Time and frequency-domain analyses of Heart rate variability were performed.  Results:  Heart rate increased significantly after premedication compared with that before premedication and increased further during endoscopy. The CV RR  values after premedication and during endoscopy were significantly higher than those before premedication (  P , 0.031 and  P,  0.041, respectively). LF power decreased during bronchoscopy. LF powers obtained after endoscopy were significantly lower than those obtained before endoscopy (  P  l 0.041). The HF power was found to be decreased during bronchoscopy. In particular, HF powers obtained after endoscopy were significantly lower than those obtained before endoscopy ( P  l 0.019). Although the LF/HF ratios increased after premedication, they decreased temporarily during the endoscope insertion.  Conclusion: This study shows for the first time that bronchoscopy induced an autonomic nervous abnormality, which may contribute to the occurrence of cardiac events during endoscopic procedures.
Exploration of hereditary cancer and feasibility of genetic services at the end of life
Authors: J. M. Quillin, J. N. Bodurtha, L. A. Siminoff, T. J. Smith
Journal: Journal of Clinical Oncology (2009)

9578 Background: For families, optimal hereditary cancer assessment begins with an affected relative. End of life could be the last chance for testing or DNA banking. Many palliative care oncologists do not feel qualified to offer genetic services and are rarely doing so (NSGC, 2008). The genetic burden of cancer in palliative care is unknown. Methods: We investigated prevalence of hereditary cancer among dying cancer patients, previous genetic testing or DNA banking, and awareness and intentions regarding these services. In spring/summer 2008 we recruited and interviewed patients (or surrogate decision makers) from the VCUHS Palliative Care Unit. Genetic risk was characterized as “strong” using classification criteria developed by Scheuner et al. (1997) or other consensus diagnostic criteria. Statistics were assessed using SAS 9.1.3. Results: 43 (47%) patients (including 9 surrogates) agreed to participate. The most common diagnoses were leukemias/lymphomas (n=9), and cancers of the lung (n=8), colon (n=5), and breast (n=4). 8 of 43 (18.6%, 95% CI = 7.0% to 30.2%) patients had “strong” genetic risk. Currently available genetic tests could have addressed risk for several patients, especially for HNPCC and hereditary breast/ovarian cancer. None had previous testing or DNA banking. Of strong-risk patients (or surrogates), 7 (87.5%) had heard/read “almost nothing” or “relatively little” about testing. All had heard/read little or nothing about DNA banking. 83% would “probably get tested” if offered, and 72% would “probably” or “definitely” bank DNA. There were no significant differences by race/ethnicity, nor by genetic risk. Conclusions: The genetic burden of cancer may be at least as high in the palliative care population as in other clinical settings and is not being discovered upstream. Patient interest in genetic services is high, but awareness is low. No significant financial relationships to disclose.
Rhus Dermatitis from Rhus Toxicodendron, Radicans and Diversiloba (Poison Ivy): Its Pathology and Chemotherapy.
Authors: James Birtley McNair
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MLN8054, an orally active Aurora A kinase small molecule inhibitor in phase I clinical trials
Authors: Mark Manfredi, Jeffrey Ecsedy, Kristan Meetze, Suresh Balani, Olga Burenkova, Wei Chen, Kara Hoar, Jessica Huck, Patrick Leroy, Todd Sells, Steve Stroud, Tricia Vos, Deborah Wysong, Mengkun Zhang, Christopher Claiborne
Journal: Cancer Research (2006)

4724  The Aurora family of mitotic kinases play key roles in proper cell cycle progression. Aurora A and Aurora B are overexpressed in several human tumors and the Aurora A gene is amplified in a variety of cancers including breast, colon, and pancreatic. Due to their role in cancer, these kinases have been pursued as potential drug targets. Small molecules that inhibit both Aurora A and Aurora B kinase have been described in the literature and three have entered clinical trials. Here, we describe the first selective inhibitor of Aurora A to enter phase I clinical trials, MLN8054. MLN8054 selectively inhibits Aurora A over Aurora B in cultured human tumor cells and treatment results in phenotypes consistent with Aurora A inhibition including accumulation of mitotic cells with spindle abnormalities, and apoptosis. MLN8054 is orally bioavailable with a favorable pharmacokinetic profile to support once a day dosing in mice. A single oral administration of MLN8054 to nude mice bearing human colon tumor lines SW480 and HCT-116 resulted in a time-dependent accumulation of mitotic cells (beginning 4 hours after treatment) as detected by immunofluorescent staining for two mitotic markers. These in vivo results are consistent with MLN8054 mediating pharmacological effects through Aurora A inhibition. MLN8054 did not inhibit Aurora B in vivo at therapeutic doses as determined by the presence of staining in tumor tissue for the Aurora B substrate phosphorylated histone H3 (Ser10). Repeat dosing of MLN8054 induced apoptosis (starting on day 3) and tumor growth inhibition in several tumor models with once or twice a day dosing. MLN8054 is the first reported selective inhibitor of Aurora A kinase that robustly inhibits growth of human tumor xenografts and represents a novel modality for therapeutic intervention of human cancers.