tbuckley/cabot-search huggingface dataset:
Abstract 383: Heart-Kidney: Myocardial Infarction Mediates Renal Fibrosis and Activates Renal Molecular Remodeling in the Absence of Heart Failure
Authors: Fernando L Martin, Brenda K Huntley, Gerald E Harders, Sharon M Sandberg, Horng H Chen, John C Burnett
Journal: Circulation (2007)

Background : Studies in human myocardial infarction (MI) suggest that even in the absence of heart failure (HF) alterations in renal function may occur and contribute to poor outcomes. After MI a decline in renal function may be seen acutely by mechanisms which are unclear. The long term consequences of MI upon renal function and structure remain poorly defined. We hypothesized that even without pre-existing renal disease, renal functional and structural changes would be present following MI. Methods : Cardiorenal function and structure were assessed in Wistar rats, Sham (S; n=10) and MI groups (n=9) 3 weeks after MI. GFR was determined by inulin clearance. Blood was obtained for PRA and aldosterone. Hearts and kidneys were harvested for histological analysis. Cardiac function was assessed by echo. Genome-wide microarray analysis was performed on kidney cortex (KC) and medulla (KM) (Affymetrix GeneChip® Rat Genome 230 2.0). Results : EF decreased after MI (S:62.8±2.3, MI:42.8±6.5 %, p&lt;0.01) and LVEDd increased (p&lt;0.005) PRA and aldosterone activation were absent. Blood pressure (BP) was not different between groups. There was no HF as sodium and water excretion was maintained. GFR tended to decrease (S:2.9±0.3, MI:2.4±0.2 ml/min, NS). Picrosirius Red staining for collagen in the KC and KM after MI showed greater fibrosis especially in the RM (KC S:1.1±0.2, MI:3.5±0.6 %, p&lt;0.001 and KM S:1±0.2, MI:18.8±6 %, p&lt;0.005). Microarray analysis revealed that 303 genes significantly changed in KM and 407 genes in the KC after MI (1.5 fold, P&lt;0.05). Gene dysregulation was related to cell proliferation, metabolic processes and cell communication (Z value&gt;2). Conclusion : We conclude that experimental MI results in renal structural remodeling characterized by renal cortical and medullary fibrosis with a mild reduction in GFR and extensive modulation of molecular pathways related to renal growth and metabolism. This investigation provides evidence for a heart-kidney connection after MI by mechanisms which remain to be defined. We also conclude that therapies for MI targeting the heart also should be evaluated for properties of renoprotection.
Abstract 14043: Usefulness of DTI Parameters and NTproBNP to Detect Acute Rejection in Heart Transplantation
Authors: Paula Beltran Correas, Vanesa Monivas Palomero, Susana Mingo Santos, Esther Gonzalez Lopez, Manuel Sanchez Garcia, Lorena Ruiz Bautista, Isabel Zegri Reiriz, Miguel Angel Cavero Gibanel, Manuel Gomez Bueno, Javier Segovia Cubero, Luis A. Pulpon
Journal: Circulation (2012)

Heart transplantation (HT) is characterized by high left ventricular filling pressures (LVFP) and restrictive pattern at the beginning and these parameters could evolve during the follow-up. Acute ...
Abstract 12549: PKCdelta-Deficiency Accelerates Neointimal Lesions in a Mouse Model of Vascular Injury Involving Delayed Reendothelialization and Vasohibin-1 Accumulation
Authors: Yanhua Hu, Xue Bai, Andriana Margariti, Qingbo Xu
Journal: Circulation (2010)

Background: Protein kinase C (PKC) delta functions as a signal transducer mediating several essential functions of cell proliferation and apoptosis. However, the effect of PKCdelta on neointimal fo...
Does growing old increase the risk for depression?
Authors: R E Roberts, G A Kaplan, S J Shema, W J Strawbridge
Journal: American Journal of Psychiatry (1997)

Most research examining age as a risk factor for depression has been based on cross-sectional data. To investigate the effect of aging on rates of depression prospectively, the authors used two waves of data from a panel study of community residents 50 years old and older.Data on symptoms of major depressive episodes were examined for the 1994 and 1995 cohorts of the Alameda County Study. The authors examined age, gender, marital status, education, financial strain, chronic medical conditions, functional impairment, cognitive problems, life events, neighborhood problems, social isolation, and social support. Depression was measured with 12 items covering DSM-IV diagnostic criteria for major depressive episodes.Point prevalence of major depressive episodes was 8.7% in 1994 and 9.0% in 1995. Among the subjects 60 years old and older, there was a tendency toward higher prevalence in 1995. The highest prevalence rates in 1994 and in 1995 were among those 80 years old and older. Subjects who were depressed in 1994 were at greater risk for depression in 1995. When the effects of age and other psychosocial risk factors in 1994 were controlled, there were no significant age effects on depression in 1995. Multivariate analyses demonstrated that the initial age effects were due mainly to chronic health problems and functional impairment. Gender, chronic health conditions, problems with activities of daily living, cognitive problems, neighborhood problems, and social isolation in 1994 all were significant predictors of depression in 1995.Healthy, normally functioning older adults are at no greater risk for depression than younger adults. What seem to be age-related effects on depression are attributable to physical health problems and related disability.
Comprehensive side-effect profile of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: long-term safety analysis of the ATAC trial
Authors: A Buzdar, A Howell, J Cuzick, C Wale, W Distler, G Hoctin-Boes, J Houghton, G Y Locker, J M Nabholtz
Journal: The Lancet Oncology (2006)
Abstract 4454: The Influence of Anemia After Percutaneous Coronary Intervention on Clinical Outcomes
Authors: Sudhakar Sattur, Kishore J Harjai, Arvin Narula, Srinivas Devarakonda, Pamela Orshaw, Karl Yaeger
Journal: Circulation (2008)

Although the consequences of bleeding after percutaneous coronary intervention (PCI) are well documented, there are no data on the impact of post-PCI anemia (PPA) on clinical outcomes. We evaluated...
Abstract 5600: Coronary Artery Distensibility and Plaque Composition Determined by Virtual Histology-IVUS - Comparison between Stable Angina Pectoris and Acute Myocardial Infarction
Authors: Osamu Sasaki, Toshihiko Nishioka, Ami Isshiki, Yoshiro Inoue, Aki Kaneda, Kentarou Toyama, Toshiyuki Ando, Mikio Yuhara, Shunichi Sato, Nobuyuki Masaki, Tetsuo Kamiyama, Masato Kirimura, Shunichi Tsukada, Hiroyuki Ito, Yoshiaki Maruyama, Nobuo Yoshimoto
Journal: Circulation (2008)

The purpose of this study was to assess the difference in coronary artery distensibility and plaque composition determined by Virtual Histology-IVUS between non-culprit lesions of stable angina pectoris (SAP) and those of acute myocardial infarction (AMI). One-hundred thirty cross sectional areas (CSA) of 12 non-culprit de novo coronary artery lesions from 8 SAP patients and 128 CSAs of 12 non-culprit de novo coronary artery lesions from 10 AMI patients were imaged by IVUS (Volcano Therapeutics) with simultaneous intracoronary pressure (ICP) recording. Systolic and diastolic lumen areas (LA), vessel areas (VA), and plaque areas (PA) were measured. Lumen diameters (LD) were calculated with an assumption that the cross section was circular. Plaque burden; (PA/VA) X100, coronary compliance; {(LA change/diastolic LA)/(ICP change)} × 10 3 and stiffness index β (SI-β); {ln (systolic ICP/diastolic ICP)}/(LD change/diastolic LD) were calculated at each site. Color tissue maps were reconstructed from radio frequency data using IVUS-Virtual Histology software. Coronary compliance, SI-β and 4 tissue composition areas (Fibrous, Fibro-fatty, Dense-calcium and Necrotic core) were compared between SAP group and AMI group. LA, VA and PA were significantly larger in AMI group than in SAP group (7.88mm 2 vs 6.45 mm 2 , p&lt;0.0001, 16.77 mm 2 vs 14.18 mm 2 , p&lt;0.0001 and 8.88 mm 2 vs 7.73 mm 2 , p&lt;0.0001). However, plaque burden showed no significant difference between AMI and SAP groups (53.4%vs 54.0%, p=0.60). Coronary compliance was significantly lower and SI-β was significantly higher in AMI group than in SAP group (0.82±0.75vs1.85±1.28, p&lt;0.0001, 34.8±25.1vs 20.1±17.2, p&lt;0.0001). Fibrous and Fibro-fatty areas were significantly smaller in AMI group than in SAP group (51.6% vs 71.3% p&lt;0.0001, 10.1% vs 15.5% p&lt;0.0001). Dense-calcium area and Necrotic core area were significantly larger in AMI group than in SAP group (15.2% vs 2.6% p&lt;0.0001, 22.9% vs 9.9% p&lt;0.0001). Coronary atherosclerosis assessed by Virtual Histology-IVUS was more advanced and severe, and coronary distensibility was impaired even in non-culprit lesions of AMI compared to those of SAP.
Impact of Vessel Size on Outcome After Implantation of Sirolimus-Eluting and Paclitaxel-Eluting Stents
Authors: Mario Togni, Stéphanie Eber, Jeannette Widmer, Michael Billinger, Peter Wenaweser, Stéphane Cook, Rolf Vogel, Christian Seiler, Franz R. Eberli, Willibald Maier, Roberto Corti, Marco Roffi, Thomas F. Lüscher, Ali Garachemani, Otto M. Hess, Simon Wandel, Bernhard Meier, Peter Jüni, Stephan Windecker
Journal: Journal of the American College of Cardiology (2007)
Abstract 15760: The Relationship Between Distinct Endothelial Progenitor Cell Populations and the Physiological Severity of Coronary Artery Disease in Humans
Authors: Kim H. Chan, Phillipa Simpson, Andy Yong, Chirapan Chawantanpipat, Chi-Jen Hsu, Patrick Lim, Louise L. Dunn, Martin Ng
Journal: Circulation (2011)

Objectives: Endothelial progenitor cells (EPCs) are implicated in cardiovascular repair and regeneration. However, previous studies showed conflicting results when relating endogenous EPCs to exten...
Abstract 12761: Incidence and Prevalence of Peripheral Artery Disease and Critical Limb Ischemia in an Insured National Population
Authors: Mark R Nehler, Sue Duval, Armen Zakharyan, Brian H Annex, Lihong Diao, William R Hiatt, Alan T Hirsch
Journal: Circulation (2012)

Context: Critical limb ischemia (CLI) represents the most severe clinical manifestation of peripheral artery disease (PAD) and is the major cause of ischemic amputation in the United States. CLI is...
Abstract 1448: Thiazolidinediones and the Risk of Incident Congestive Heart Failure Among Patients With Type 2 Diabetes Mellitus: A Population-Based Nested Case-Control Study
Authors: Kristian B Filion, Lawrence Joseph, Jean-Francois Boivin, Samy Suissa, James M Brophy
Journal: Circulation (2009)

Background: Recent clinical trials suggest that thiazolidinediones (TZDs) may increase the risk of congestive heart failure (CHF). However, the effect of TZDs on the risk of incident CHF in unselec...
Abstract 1584: Epidemiology of Hemorrhagic and Gastrointestinal Adverse Effects of Low-dose Aspirin for Primary Prevention of Atherosclerotic Events in Type 2 Diabetic Patients: Insights From JPAD Trial
Authors: Takeshi Morimoto, Hisao Ogawa, Masafumi Nakayama, Shiro Uemura, Masao Kanauchi, Naofumi Doi, Hideaki Jinnouchi, Hirofumi Soejima, Seigo Sugiyama, Masako Waki, Takahiro Kawano, Yoshihiko Saito
Journal: Circulation (2009)

Objectives: Low-dose aspirin is frequently used for primary prevention of atherosclerotic events in diabetic patients. Because the risk of hemorrhagic and gastrointestinal adverse effects of aspiri...
Abstract 738: Role of the Pulmonary Veins in Experimental Paradigms of Remodeling- Basic Science Associated Atrial Fibrillation
Authors: Masao Sakabe, Kristina Lemola, Katsuyoshi Chiba, Grigorios Katsouras, Akiko Shiroshita-Takeshita, Stanley Nattel
Journal: Circulation (2007)

Background : Pulmonary vein (PV) activity is crucial in some forms of clinical atrial fibrillation (AF), particularly paroxysmal lone AF. The precise importance of PVs in AF associated with structural heart disease is less clear. Some evidence suggests that PVs may be important for AF in experimentally-remodeled atrial substrates, e.g. atrial-tachycardia remodeling (ATR) and congestive heart failure (CHF)-induced structural remodeling, but contradictory findings also exist. This study assessed the role of PVs in canine remodeling-associated AF by evaluating the changes induced by PV-LA disconnection via encircling epicardial ablation. Methods: AF was induced before and after complete isolation of all PVs in dogs with: ATR induced by atrial tachypacing (400 bpm x 1 wk; with AV block and 80 bpm ventricular pacing to control ventricular rate, n=5); and CHF induced by ventricular tachypacing (VTP, 240 bpm x 2 wks, n=7). Electrophysiological measurements and AF mapping with 240 unipolar atrial electro-grams in both atria and all PVs were also obtained before and after PV isolation. Results ATR reduced atrial ERPs and ERP rate adaptation. The shortest AF cycle length (AFCL) in each ATR dog was recorded from PVs (mean 84±3 ms), but the mean AFCL in each of the PVs (range 97–103 ms) was not different from the mean AFCL at LA sites (98 –103 ms). PV ablation did not affect AF duration in ATR dogs (mean 284±265 pre- vs. 304±225 s post-ablation, P=NS), nor did it significantly alter RA or LA AFCL. In CHF dogs, ERPs and ERP rate adaptation were preserved. The shortest AFCL was recorded in PVs in 2 dogs (108,112 ms) and in the left side of Bachmann’s bundle in 3 (97–117 ms). PV ablation failed to alter AF duration in CHF dogs (mean 778±203 pre- vs. 644±206 s post-ablation), and increased AFCL in RA and LA slightly (10 –15%) but not significantly. Conclusions : Uncoupling of the PVs from the LA fails to significantly affect the AF substrate in 2 clinically-relevant animal paradigms of AF-promoting atrial remodeling. These findings suggest that in the presence of a favorable atrial substrate for AF the PVs are not needed for AF maintenance, and are consistent with clinical observations that complete PV isolation may not be essential for effective ablation therapy of all groups of AF patients.
Abstract 14082: Coronary Artery Bypass Grafting Using the Radial Artery: Clinical Outcomes and Patency
Authors: Robert F Tranbaugh, Kamellia R Dimitrova, Patricia Friedmann, Charles M Geller, Wilson Ko, Darryl M Hoffman
Journal: Circulation (2011)

Objective:  Radial artery (RA) grafts are an attractive second arterial conduit after the left internal thoracic artery (LITA) for coronary artery bypass surgery (CABG). However, long term outcomes and the need for subsequent reintervention have not been defined.   Methods:  We performed a retrospective cohort study of our single institution9s 16 year experience with 1,851 consecutive patients (average age 58 years, 82% male, 36% diabetic) undergoing primary, isolated CABG with the LITA and RA. Saphenous vein (SV) was used as necessary. Average grafts per patient were 3.8 with 2.4 arterial grafts per patient. Clinical data and results were collected prospectively as part of an audited and state mandated cardiac surgery reporting system. Survival was determined using the Social Security Death Index. Grafts were nonpatent if they had a >50% stenosis, a string sign or were occluded.   Results:  Four patients (0.2%) died in hospital and 0.8% had a myocardial infarction, 0.9% a stroke and 0.7% renal failure. Kaplan Meier estimated 1, 5, 10 and 15 year survival was 99%, 96%, 89% and 75%. Of the cohort, 278 symptomatic patients underwent cardiac catheterization at our institution an average of 5.0 + 3.8 years (range 0.1 to 12 years) after CABG. Overall RA (n=415 grafts) patency was 80% and SV (n=364 grafts) patency 47% (p   Conclusions:  RA grafting is a highly effective revascularization strategy providing excellent short and long term outcomes with very low rates of reintervention. RA patency is similar to LITA patency and is much better than SV patency. RA grafting should be more widely utilized in patients undergoing CABG.
Abstract 3052: Efficacy of Cerebrospinal Fluid Drainage and Naloxone for Endovascular Repair of Thoraco-Abdominal Aortic Aneurysms
Authors: Toru Kuratani, Yukitoshi Shirakawa, Kazuo Shimamura, Mugiho Takeuchi, Satoshi Kamihira, Goro Matsumiya, Masaaki Kato, Yoshiki Sawa
Journal: Circulation (2007)
Abstract 233: Novel Roles of Notch2 and Notch3 in Differential Regulation of Cardiovascular Calcification
Authors: Gabriel Rusanescu, Masanori Aikawa, Ralph Weissleder, Elena Aikawa
Journal: Circulation (2009)

Background: We previously demonstrated that Notch receptors contribute to aortic valve calcification, however the underlying mechanisms, particularly relative contributions of each receptor remain ...
Abstract 3573: Higher Soluble Thrombomodulin is Associated with Risk of Coronary Artery Calcification: Longitudinal Analysis of the Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Dhananjay Vaidya, Mary Cushman, Paul Holvoet, Joseph F Polak, Robyn L McClelland, Moyses Szklo, Pamela Ouyang
Journal: Circulation (2007)

Background. A prior cross sectional study reported that higher soluble thrombomodulin (sTM) was associated with subclinical atherosclerosis only in the presence of higher soluble intercellular adhesion molecule-1, sICAM-1. We evaluated this interaction longitudinally with regard to coronary artery calcium (CAC) in the MESA cohort. Methods: MESA is a multi-center longitudinal study with baseline measurements of endothelial biomarkers in a random sample (n=1000) of the baseline cohort. In the random sample, 374 men and 496 women had CT measurement for CAC (Agatston score) at baseline and a median follow-up of 2.9 years. Among those with no baseline CAC (n=490), we estimated the relative risk of detectable CAC at follow-up using general linear models with Gaussian error and robust standard errors. Among those with detectable baseline CAC (n=380), change in CAC on follow-up was modeled using robust regression that down-weights outliers. Models with log(sTM) as predictor were adjusted for follow-up time, sex, ethnicity and baseline age, BMI, smoking, diabetes, systolic blood pressure, total cholesterol, use of BP or lipid-lowering medications and for hormone replacement (HRT) in women in separate models. Interactions between sTM and sICAM-1, sex and ethnicity was assessed. Results: The median [interquartile range] of sTM was 38 [28 to 47] ng/mL for persons with incident detectable CAC, and 30 [23 to 41] ng/mL in those without (rank sum p &lt;0.001). On adjustment, a 2-fold higher sTM at baseline (e.g., from 23 to 46 ng/mL) was associated with a 1.36-fold increased risk of detectable CAC on follow-up (95% CI: 1.03, 1.79, p=0.031). Among those with baseline detectable CAC, the rank correlation between sTM level and change in CAC score was 0.10 (p = 0.042), however, on adjustment, a 2-fold higher sTM was associated with a non-significant 0.86 Agatston units greater CAC change (p = 0.84). Higher sICAM-1 did not modify the association of sTM with CAC incidence (interaction p = 0.15) or change (interaction p = 0.26). There was no significant heterogeneity by sex, or ethnicity, or confounding by HRT in women. Conclusion: High circulating levels of sTM were independently associated with incident calcification of the coronary arteries.
Abstract 9266: Heart Failure, Atrial Fibrillation and Neuromuscular Disorders Determine Mortality in Left Ventricular Noncompaction
Authors: Claudia Stoellberger, Gerhard Blazek, Christian Wegner, Josef Finsterer
Journal: Circulation (2011)

Objectives and Background: The long-term prognosis of patients with left ventricular hypertrabeculation/noncompaction (LVHT) is assessed controversially. Aim of the study was to assess parameters influencing mortality and to compare the mortality of LVHT-patients with that of the Austrian general population. Methods: Included were all patients in whom LVHT was diagnosed in the echocardiographic laboratory of the KA Rudolfstiftung between June 1995 and February 2011. They underwent a baseline cardiologic examination and were invited for a neurological investigation. Between January and February 2011, the patients were contacted by telephone and assessed if the patient was alive or not. Results: LVHT was diagnosed in 162 patients (46 female, mean age 53±16 years) with a prevalence of 0.31%/year. Hundred-sixteen patients (72%) underwent a neurological investigation which revealed specific neuromuscular disorders (NMD) in 25, a NMD of unknown etiology in 74, and was normal in 17 patients. During a mean follow-up of 67 months, the mortality was 4.8%/years and the standardized mortality ratio 6.27 compared with the general Austrian population. By multivariate analysis, significant predictors for mortality were heart failure (Hazard-ratios 3.91, 4.48 and 5.37 for NYHA II, III and IV), atrial fibrillation (Hazard-ratios 3.26) and presence of NMD, either specific or of unknown etiology (Hazard-ratio 1.86). Conclusion: Prognostic predictors in LVHT are heart failure, atrial fibrillation and NMD, which stresses the need for a neurologic investigation. Heart failure and atrial fibrillation should be treated consequently in LVHT.
A Phase II Trial of 200% ProMACE-CytaBOM in Patients With Previously Untreated Aggressive Lymphomas: Analysis of Response, Toxicity, and Dose Intensity
Authors: Leo I. Gordon, Mary Young, Edie Weller, Thomas M. Habermann, Jane N. Winter, John Glick, Chirantan Ghosh, Patrick Flynn, Peter A. Cassileth
Journal: Blood (1999)
Acute Myocardial Infarction Early Viability Assessment by 64-Slice Computed Tomography Immediately After Coronary Angiography
Authors: Michel Habis, André Capderou, Saïd Ghostine, Béatrice Daoud, Christophe Caussin, Jean-Yves Riou, Philippe Brenot, Claude Yves Angel, Bernard Lancelin, Jean-François Paul
Journal: Journal of the American College of Cardiology (2007)
THE CHICAGO OUTBREAK OF AMEBIASIS
Authors: E K Markell
Journal: JAMA (1934)

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