Acupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in Pregnancy
Authors: Arthur Yin Fan, Sherman Gu
Journal: Annals of Internal Medicine (2024)

LettersFebruary 2024Acupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in PregnancyArthur Yin Fan, MD(CNH), PhD, LAc, and Sherman Gu, BMed, MAppSc, PhDArthur Yin Fan, MD(CNH), PhD, LAcMcLean Center for Complementary and Alternative Medicine, Vienna, Virginia, and Sherman Gu, BMed, MAppSc, PhDKnox Chinese Healing and Myotherapy, Wantirna South, Victoria, AustraliaAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L23-0425 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: Wu and colleagues (1) conducted a multicenter, randomized, double-blind, placebo-controlled 2 × 2 factorial trial of acupuncture and doxylamine–pyridoxine for moderate or severe nausea and vomiting of pregnancy (NVP). They concluded that both acupuncture and doxylamine–pyridoxine alone are efficacious for moderate and severe NVP and that the combination of acupuncture and doxylamine–pyridoxine may yield a potentially larger benefit than each treatment individually.In 1997, a National Institutes of Health consensus panel reported that evidence was available supporting acupuncture for NVP (2). Lao and associates' (3) study in the ferret emesis model also showed that acupuncture was effective and that ...References1. Wu XK, Gao JS, Ma HL, et al. Acupuncture and doxylamine–pyridoxine for nausea and vomiting in pregnancy. A randomized, controlled, 2 × 2 factorial trial. Ann Intern Med. 2023;176:922-933. [PMID: 37335994] doi:10.7326/M22-2974 LinkGoogle Scholar2. National Institutes of Health. Acupuncture. NIH Consens Statement. 1997;15:1-34. [PMID: 10228456] MedlineGoogle Scholar3. Lao L, Zhang G, Wong RH, et al. The effect of electroacupuncture as an adjunct on cyclophosphamide-induced emesis in ferrets. Pharmacol Biochem Behav. 2003;74:691-9. [PMID: 12543236] CrossrefMedlineGoogle Scholar4. Persaud N, Meaney C, El-Emam K, et al. Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: prespecified analyses and reanalysis. PLoS One. 2018;13:e0189978. [PMID: 29342163] doi:10.1371/journal.pone.0189978 CrossrefMedlineGoogle Scholar5. Zia FZ, Olaku O, Bao T, et al. The National Cancer Institute's conference on acupuncture for symptom management in oncology: state of the science, evidence, and research gaps. J Natl Cancer Inst Monogr. 2017;2017. [PMID: 29140486] doi:10.1093/jncimonographs/lgx005 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Arthur Yin Fan, MD(CNH), PhD, LAc; Sherman Gu, BMed, MAppSc, PhDAffiliations: McLean Center for Complementary and Alternative Medicine, Vienna, VirginiaKnox Chinese Healing and Myotherapy, Wantirna South, Victoria, AustraliaDisclosures: Authors have reported no disclosures of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L23-0425. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAcupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in Pregnancy Xiao-Ke Wu , Jing-Shu Gao , Hong-Li Ma , Yu Wang , Bei Zhang , Zhao-Lan Liu , Jian Li , Jing Cong , Hui-Chao Qin , Xin-Ming Yang , Qi Wu , Xiao-Yong Chen , Zong-Lin Lu , Ya-Hong Feng , Xue Qi , Yan-Xiang Wang , Lan Yu , Ying-Mei Cui , Chun-Mei An , Li-Li Zhou , Yu-Hong Hu , Lu Li , Yi-Juan Cao , Ying Yan , Li Liu , Yu-Xiu Liu , Zhi-Shun Liu , Rebecca C. Painter , Ernest H.Y. Ng , Jian-Ping Liu , Ben Willem J. Mol , and Chi Chiu Wang Acupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in Pregnancy Qi Wang Acupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in Pregnancy Jing-Shu Gao , Hong-Li Ma , Chi Chiu Wang , Tian Xie , Xiao-Ke Wu Metrics Current IssueFebruary 2024Volume 177, Issue 2KeywordsAcupunctureNauseaPregnancyRandomized trialsVomiting ePublished: 20 February 2024 Issue Published: February 2024 Copyright & PermissionsCopyright © 2024 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...