tbuckley/cabot-search huggingface dataset:
Tuberculin in Diagnosis and Treatment.
Authors: Francis Marion Pottenger
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15134: Calcium-Modulated Protein S100a8/a9: Novel And Sensitive Biomarker for Early Diagnosis of Acute Coronary Syndromes
Authors: Salvatore De Rosa, Stephan Fichtlscherer, Ralf Lehmann, Tino Roexe, Stephanie Estel, Stefanie Dimmeler, Andreas M Zeiher
Journal: Circulation (2011)

Plaque instability and rupture leads to coronary thrombosis, the pathophysiologic substrate of acute coronary syndromes (ACS). Transcriptional profiling studies in patients with ACS identified the ...
Abstract 3501: Azimilide Reduces Arrhythmic-Related ER visits and Hospitalizations in Patients with an ICD: Results from the SHIELD trial
Authors: Paul Dorian, Hussein Al Khalidi, Stefan Hohnloser, Jose Brum, Craig Pratt, Martin Borggrefe, Klinikum Mannheim, Johannes Brachmann, Landkrankenhaus Coburg, David Cannom, Robert Myerburg
Journal: Circulation (2006)
The 21st Century Cures Act — Will It Take Us Back in Time?
Authors: Jerry Avorn, Aaron S Kesselheim
Journal: New England Journal of Medicine (2015)

Interview with Dr. Jerry Avorn on the 21st Century Cures Act’s potential implications for drug development and safety. (08:23)Download In recent months, the FDA has declined to permit use of eight new sunscreen ingredients (that are already in use in Europe) without additional data. The controversy says as much about how the agency works as it does about sunscreen regulation.
Where Angels Dared to Tread
Authors: V. F. Calverton
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2400: Late Gadolinium Enhancement on MRI is a Prognostic Marker of Poor Survival in Light Chain Amyloidosis: Results from Long-Term Follow Up
Authors: Raymond Q Migrino, Megan Bright, Nicholas Pajewski, Seth Truran, David D Gutterman, Parameswaran Hari
Journal: Circulation (2008)

Light chain amyloidosis (AL) is a rare disease associated with poor survival especially in the presence of cardiac involvement. Late gadolinium enhancement (LGE) on cardiac MRI was recently shown to correspond to cardiac amyloid deposition but the long term prognostic implication of this finding has not been established. The aim is to compare long-term survival between AL subjects with and without LGE. 25 biopsy-proven AL subjects (12 females, 61 ± 3 years) underwent cardiac MRI while undergoing workup for AL. Survival status was followed 24 ± 10 months post-MRI and compared between LGE positive and negative subjects. LGE was present in 19 (76%) AL subjects. 13 (52%) were in Heart Failure (HF) Class I with 7 (28%), 2 (8%) and 3 (12%) in Class II, III, IV respectively. LVEF was 65 ± 18% in LGE positive and 69 ± 12% LGE negative patients (p = 0.6). On follow up 10/19 LGE positive and 0/6 LGE negative patients died (log rank p = 0.03). LGE and initial presenting HF class (log rank p = 0.001) were associated with poor survival (see figure ). There was no significant association between LGE and initial presenting HF class (Fisher’s exact p = 0.4). This is the first long-term study demonstrating the prognostic significance of LGE in AL amyloidosis. Although small sample size precludes modeling the independent prognostic value of LGE, the lack of strong association with HF class and the presence of LGE in HF Class I subjects suggest additional utility of LGE in assessing the prognosis of AL subjects.
Verotoxin-1 Binding to Human Monocytes Results in Induction of Cytokine Release
Authors: P.A. van Setten, L.P. van den Heuvel, H.G.G. Verstraten, Karmali, V.W.M. Hinsbergh, L.A.H. Monnens
Journal: Journal of the American Society of Nephrology (1995)
Antibiotics and Chemotherapy
Authors: H. Schönfeld, F. E. Hahn
Journal: New England Journal of Medicine (1951)

Book reviews afforded ovarian tumours elsewhere in the book.Moreover, this has to some extent introduced terminological confusion, par- ticularly in the germ cell section.Overall the book is beautifully pro- duced with great attention to detail and numerous references.It is obviously a work that will be in demand by those with a special interest in gynaecological pathology and is recommended as a valuable reference book for the shelves of any medical library.
Anticoagulation for patients with atrial fibrillation
Authors: N. Dudley
Journal: BMJ (2000)

Editor—Connolly's view that Kalra et al's findings clearly show that the results of anticoagulation studies can be replicated in general medical practice may be an overinterpretation of the data.1,2 The 167 patients in the study may not have been a representative sample of high risk patients found in general practice. Patients were recruited from secondary care medical clinics, not general practice, and bias in the study group could have been introduced by selection for hospital referral. Furthermore, bias could have occurred by exclusion of those high risk patients who were already taking warfarin, who may have been considered by their general practitioner to have been at a lower risk of haemorrrhagic complications or a greater risk of stroke. Knowledge of the outcome of the 76 patients already taking warfarin, who presumably were being managed by the same anticoagulation service as trial patients, is also required.

The most striking finding from Kalra et al's study was that 167 of 172 (97%) high risk patients agreed to warfarin treatment. Knowledge of how this level of acceptance was achieved would be useful for clinical practice. Howitt and Armstrong found that after patients in general practice were educated about stroke, given detailed information about aspirin and warfarin, and shown a pictorial representation of risk and expected benefits of treatment only 10 of 56 patients started warfarin, 20 declined treatment, one changed from warfarin to aspirin, and the remainder continued to take warfarin.3 In contrast, Sudlow et al found that 78% of women and 93% of men aged 75 and over, the majority of whom were at high risk, would take a tablet (warfarin) to prevent stroke, but patients were only told the overall benefits of treatment and not told specifically about risks.4 Acceptance of treatment declined if anticoagulation monitoring was carried out at the hospital or general practitioner's surgery. The same group has also highlighted the factors influencing general practitioners' use of warfarin and did not find that warfarin was considered too expensive to manage in primary care and willingness to use it could be encouraged by further remuneration.5

Maybe it is not crucial to educate doctors about the benefits of warfarin, but perhaps the key to increasing its use in high risk patients is to adopt Kalra et al's approach to discussing “warfarinisation,” whatever that is, deliver the monitoring service in the patient's home, and remunerate general practitioners adequately for supervising the treatment and screening patients to identify those who would be eligible for treatment.
Abstract 3103: A New Epidemic of Heart Failure in the United States: Findings from the National Hospital Discharge Surveys, 1980–2006
Authors: Longjian Liu
Journal: Circulation (2008)

Introduction: The most common diagnosis in hospitalized patients aged 65 or older is heart failure (HF). The study aimed to assess the hypothesis that HF hospitalization rates increased significantly in the last 27 years. Methods: Data from National Hospital Discharge Surveys (NHDS) between 1980 and 2006 was analyzed in depth. The NHDS was conducted with a multi-stage cross-sectional study design. HF was diagnosed according to ICD 9 th - CM version. It was then listed from first to seven diagnosis of HF. In the present study, patients with first-listed diagnosis of HF were defined as cases. Census estimated population data were used to estimate age and gender-specific hospitalization rates. Linear and multivariate Poisson regression analysis methods were used to estimate the long-term trend and relative risk of HF hospitalization by age, sex and time periods. Results: A total of 2,225,205 patients aged 65 or older were included in the study. Age-adjusted HF hospitalization rates significantly increased from 1980 to 2006, with an estimated annual percentage increase rates (95%CI) of 1.20% (0.76% ~ 3.17%) in men and of 1.55% (0.42% ~ 3.51%) in women. Poisson regression models indicate that the relative risk (95%CI) of being hospitalized due to HF in subjects living in the last 5-years of period (2002– 06) was 1.37 times higher (95%CI: 1.31 ~ 1.42) than those living in the early years of 1980 – 84. Subjects aged 85+ had 4 times higher risk of being hospitalization due to HF as compared to those aged 65–74. Furthermore, among three major forms of cardiovascular disease (CHD, stroke and HF), HF was the only disease showing a significantly increasing in the recent decades. In conclusion, the study for the first time documents the last 27 years trend of HF hospitalization rates among the elderly. It suggests that effective prevention strategies are urgently needed to control the unfavorable new epidemic of the disease.
1346 THE RELATIONSHIP BETWEEN HEPATIC STEATOSIS IL28B AND RESPONSE IN PATIENTS WITH CHRONIC HEPATITIS C
Authors: H.L. Tillmann, K. Patel, A. Muir, C. Guy, J.H. Li, X.Q. Lao, A.J. Thompson, P.J. Clark, S.D. Gardner, J.G. McHutchison, J.J. McCarthy
Journal: Journal of Hepatology (2011)
Les syndromes respiratoires.
Authors: Émile. Sergent
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combined brachytherapy and external beam radiation for prostate cancer in a community setting
Authors: G. J. Kubicek, G. J. Kubicek, S. Brown, S. Redfield
Journal: Journal of Clinical Oncology (2009)

e16147 Background: Prostate cancer is the most common male malignancy, and there is no one standard treatment modality. One treatment option is the combination of external beam radiotherapy and permanent transperineal brachytherapy seed implant Methods: Retrospective review of prostate cancer and side effect outcomes at a single institution in the community setting. All patients were treated with a combination of low dose rate transperineal brachytherapy seed placement and external beam radiation. Results: A total of 897 patients were analyzed, 781 had a minimum follow-up of one year. Median pre-treatment PSA was 8.1 (range 0.3 to 106) and the median Gleason score was 6. With a median follow-up of 3.6 years, 33 (3.4 %) patients had biochemical failure based on the phoenix definition of Nadir + 2. Not including impotence, acute toxicity greater than or equal to Grade 2 was seen in 115 patients (102 GU and 13 GI) and 193 patients had late toxicity greater than or equal to Grade 2 (155 GU and 38 GI). 563 patients received hormone therapy prior to or concurrent with the radiation. Conclusions: This is the largest series reporting on the outcome of combination brachytherpay implant and external beam radiation in the treatment of prostate cancer. Combination treatment using brachytherapy and external beam radiation is well tolerated, with a low rate of biochemical failure and should be considered one of the treatment options for prostate cancer. No significant financial relationships to disclose.
The experience of a sample of Canadian men with breast cancer
Authors: E. N. Pituskin, B. Williams, K. Martin-Mcdonald, H. Au
Journal: Journal of Clinical Oncology (2006)

10549 Background: Breast cancer is the most frequently diagnosed malignancy among North American women, accounting for about 30% of all new cases each year. Although male breast cancer accounts for less than 1% of all breast cancer cases, recent reports indicate significantly increasing incidence. Research suggests that men diagnosed with breast cancer experience serious psychologic issues including feeling less masculine by having a woman’s disease, feeling isolated with a rare malignancy and feeling uncomfortable seeking or receiving support. Men may also experience post-surgical effects including changed appearance of the male chest and decreased arm strength. There have been numerous large-scale studies examining womens’ experiences with breast cancer. To date, there have been no North American studies examining what a man experiences with a breast cancer diagnosis. The objective of this qualitative study was to determine the experiences of a sample of Canadian men diagnosed with breast cancer. Methods: After ethics approval, an invitation letter and consent form were mailed to those individuals listed as “male”, “breast cancer”, and “alive”, in the Alberta Cancer Registry. 20 men responded indicating their interest. After written consent, audiotaped interviews were conducted. As little is known about a man’s experience with breast cancer, an exploratory qualitative methodology was utilized. Results: We found a great variability among the participants with respect to whom they disclosed their diagnosis, how they viewed their masculinity after a breast cancer diagnosis and their views on life after a cancer experience. All participants stated that there was a major lack of awareness about male breast cancer, both in the public and health professional domain. All participants identified a lack of written information specific for men with breast cancer. All participants denied interest in traditional “support” groups, but would have welcomed the opportunity to speak with a man who had gone through similar diagnosis and treatment. Conclusions: Needs identified by the respondents include increased medical and public awareness of male breast cancer as well as specific written information. Further research is necessary to identify supports and resources helpful for male patients. No significant financial relationships to disclose.
Abstract 16909: Sarcoplasmic Reticulum Calcium Leak and Enhanced NCX Increase Occurrence of Delayed Afterdepolarisations in Atrial Myocytes from Patients with Chronic Atrial Fibrillation
Authors: Niels Voigt, Andrew W Trafford, Qiongling Wang, Xander Wehrens, Ursula Ravens, Dobromir Dobrev
Journal: Circulation (2010)

Introduction: Sarcoplasmic reticulum (SR) Ca2+ leak activates the inward Na+-Ca2+ exchange current (INCX) causing delayed afterdepolarsations (DADs) that promote arrhythmias. Whether this mechanism contributes to promotion of atrial fibrillation (AF) is unknown and was the object of this study. Methods: Membrane currents and potentials (patch clamp) and [Ca2+]i (Fluo-3) were measured in right-atrial myocytes from sinus rhythm (Ctl) or chronic AF (cAF) patients. Tetracaine (1 mM) or single-channel recordings were used to quantify SR Ca2+ leak through ryanodine-receptor channels (RyR2). Proteins were measured by immunoblotting. Results: Diastolic [Ca2+]i and SR Ca2+ content (integrated INCX during caffeine-induced [Ca2+]i transient [cCaT]) were unchanged, whereas diastolic SR Ca2+ leak was ∼50% higher in cAF than in Ctl (Figure). Calmodulin expression (+60%), CaMKII autophosphorylation (activation) at Thr287 (+40%) and Ser2808-phosphorylation (PKA/CaMKII-site) of RyR2 (+250%) were higher in cAF than in Ctl....
Abstract 10246: The Role of Lung Impedance Monitoring in the Outpatient Clinic for Predicting and Preventing of Hospitalizations of Patients With Chronic Heart Failure
Authors: Michael Shochat, Mark Kazatsker, Vladimir Gurovich, Elena Noiman, Yaniv Levy, Aya Asif, Pavel Rabinovich, David Blondheim, Avraham Shotan, Simcha Meisel
Journal: Circulation (2010)

Background: Implantable intra-thoracic impedance device has shown that lung fluid accumulation in patients with decompensated chronic heart failure (CHF) begins several days before admission, but p...
Growth Retardation as a Complication of Radiotherapy in Children with Brain Tumours
Authors: R. P. Droog, H. Behrendt, P. A. Voûte
Journal: Neuro-Oncology (1980)

Since the use of radiotherapy in the treatment of children with braintumours the prognosis of these patients has significantly improved. On the whole it concerns children with medulloblastoma, astrocytoma and ependymoma. A long-term recurrent free survival period is reached nowadays with 30–50% of these patients. Some of these children survive with moderate to serious neurological damage, while others are cured without any obvious sign of damage from the tumour or the treatment. As the follow up period of these children becomes longer and more children survive, approximately half of these long-term survivors appear to have the phenomenon of growth retardation. The growth curve of these children dips immediately after surgical and radiotherapeutical treatment. An example of this growth disturbance is shown in figure 1. Endocrinological investigation of these patients shows a lack of Growth Hormone while in most cases the other pituitary hormones are normally present. There are reasons to assume that not the tumour itself, but the radiotherapy is the cause of the development of the growth hormone deficiency.
Fibroids and Allied Tumours (Myoma and Adenomyoma): Their Pathology, Clinical Features and Surgical Treatment.
Authors: Cuthbert Henry Jones Lockyer
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15799: Snf1-Related Kinase Enhances Cardiomyocyte Metabolism and Increases Mitochondrial Membrane Potential and Glycolysis Through Tribbles Homolog 3 Downregulation
Authors: Amy K Rines, Michael A Burke, Hossein Ardehali
Journal: Circulation (2011)

Introduction: Snf1-related Kinase (SNRK) is a serine/threonine kinase with sequence similarity to AMP-activated kinase, but its function and substrates are unknown. We have found that SNRK is upreg...
Cancer and Heredity
Authors: Maud Slye
Journal: Annals of Internal Medicine (1928)

Article1 June 1928Cancer and HeredityMAUD SLYEMAUD SLYESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-12-951 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere are two aspects of this work that I wish especially to stress at this time. First I wish to show with what complete accuracy problems in the relation of heredity to disease can be worked out; second, to emphasize how great a need there is that this relation of heredity to disease should be thoroughly worked out for man, and to suggest the almost incalculable value such studies would have for the future of preventive medicine. Indeed, as I see it, they would revolutionize preventive medicine.Almost nowhere in the field of scientific research have the findings been so... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, IllinoisOtho S. A. Sprague Memorial Institute University of Chicago*Presented before the American College of Physicians, March 5, 1928, New Orleans, La. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Present Century. The Beginnings of Preventive MedicineKrebs und VererbungKrebs und Vererbung 1 June 1928Volume 1, Issue 12Page: 951-976KeywordsForecastingHeredityPreventive medicine ePublished: 1 December 2008 Issue Published: 1 June 1928 PDF downloadLoading ...