tbuckley/cabot-search huggingface dataset:
A preliminary report of a phase II trial of single-agent vinflunine as second-line treatment of advanced non-small cell lung cancer
Authors: M. Joppert, R. Boccia, S. Dakhil, R. Steis
Journal: Journal of Clinical Oncology (2007)

18156 Background: In preclinical and early clinical trials, single-agent vinflunine (a novel microtubule inhibitor) has shown activity in a variety of tumors, including non-small cell lung cancer (NSCLC). The purpose of this phase II, single-arm study is to evaluate the safety and efficacy of vinflunine administration every 3 weeks to patients with advanced NSCLC who have progressed after prior treatment with a platinum-based doublet. The primary endpoint is 1-year survival rate. This report presents preliminary safety information demonstrating the safety and tolerability of this combination. Methods: Patients = 18 years with confirmed advanced NSCLC (stage IIIB with malignant pleural effusions or stage IV) that have progressed after receiving a platinum-based doublet as first-line therapy, received vinflunine (320 mg/m 2 ) as a 20-minute IV infusion on Day 1 of each 21-day cycle. Results: At the time of analysis, 36 patients (of a planned total of 75) have received study treatment. Patient characteristics include: gender male/female, 24/12; median age 68.5 years (range 42–86); ECOG performance status 0/1, 10/26; and race Caucasian/Black, 34/2. The median number of cycles administered was 2 (range 1–9). Fourteen patients are still on study. The most common toxicities (NCI CTC version 2), regardless of causality, were Grade 3 fatigue (14.3%), asthenia (8.6%), neutropenia (8.6%), constipation (5.7%), cough (5.7%), dehydration (5.7%), vomiting (5.7%), dyspnea (5.7%), and ileus (5.7%). Grade 4 toxicities were neutropenia (22.9%) and change in mental status (5.7%). There were 5 deaths (2 from progressive disease, 1 from respiratory distress, 1 from coronary artery disease, and 1 case of sepsis possibly related to study drug). Conclusions: These preliminary results suggest that vinflunine has a manageable safety profile when used as a single agent for second-line treatment of patients with advanced NSCLC. Supported by Bristol-Myers Squibb. [Table: see text]
Wound botulism in injectors of drugs: upsurge in cases in England during 2004
Authors: D Akbulut, J Dennis, M Gent, K A Grant, V Hope, C Ohai, J McLauchlin, V Mithani, O Mpamugo, F Ncube, L De Souza-Thomas
Journal: Eurosurveillance (2005)

Wound infections due to Clostridium botulinum were not recognised in the UK and Republic of Ireland before 2000. C. botulinum produces a potent neurotoxin which can cause paralysis and death. In 2000 and 2001, ten cases were clinically recognised, with a further 23 in 2002, 15 in 2003 and 40 cases in 2004. All cases occurred in heroin injectors. Seventy cases occurred in England; the remainder occurred in Scotland (12 cases), Wales (2 cases) and the Republic of Ireland (4 cases). Overall, 40 (45%) of the 88 cases were laboratory confirmed by the detection of botulinum neurotoxin in serum, or by the isolation of C. botulinum from wounds. Of the 40 cases in 2004, 36 occurred in England, and of the 12 that were laboratory confirmed, 10 were due to type A. There was some geographical clustering of the cases during 2004, with most cases occurring in London and in the Yorkshire and Humberside region of northeast England.
The Prognostic Significance of Tumor-Associated Macrophages and NK Cells in Patients with Diffuse Large B-Cell Lymphoma Treated with RCHOP
Authors: Muchen Xie, Yongqiang Wei, Lei Yang, Fen Huang, Xiaolei Wei, Hui Jing, Xiaoxiao Hao, Hong Zeng, Ru Feng
Journal: Blood (2014)
Modern Trends in Child Psychiatry
Authors: Nolan D. C. Lewis, Bernard L. Pacella
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TULAREMIA; A REPORT OF FOUR CASES WITH UNUSUAL CONTACTS
Authors: Joseph H. Shaffer
Journal: Annals of Internal Medicine (1943)

Article1 January 1943TULAREMIA; A REPORT OF FOUR CASES WITH UNUSUAL CONTACTSJOSEPH H. SHAFFER, M.D., F.A.C.P.JOSEPH H. SHAFFER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-1-72 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen we consider tularemia, commonly known as rabbit fever, we are likely to dismiss it with the thought that it is a rather uncommon disease which is far removed from our every day medical experiences. In the past 28 years this disease, first recognized in California, has been found to cause illness in human beings in every state in the union. It is now known that tularemia in addition to affecting the rabbit, is a disease prevalent in 20 or more forms of wildlife in America. This paper calls attention to the occurrence of tularemia in individuals who have not...Bibliography1. Personal communication to Dr. Roy D. McClure from O. MCDANIEL, Director, Minnesota State Health Department. Google Scholar2. COLLINS MW: Transmission of tularemia by the domestic cat, New Orleans Med. and Surg. Jr., 1933, lxxxvi, 105. Google Scholar3. RUDESILL CL: Tularemia from the bite of a nursling kitten, Jr. Am. Med. Assoc., 1937, cviii, 2118. CrossrefGoogle Scholar4. Sources, Symptoms and Prevention of Tularemia, Pub. Health Rep., 1940, lv, no. 16, 667. Google Scholar5. MCCOYCHAPIN GWCW: Domestic animals and plague infection, Jr. Infect. Dis., 1911, ix, 278. Google Scholar6. SIMPSON WM: Tularemia, 1929, Paul B. Hoeber, Inc., New York, 46-49. Google Scholar7. FRANCISLILLIE ERD: The pathology of tularemia, National Institute of Health Bull., 1937, no. 167, 227. Google Scholar8. Tularemia infection (Bacterium tularense) found in streams, Pub. Health Rep., 1940, lv, no. 6, 227. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Delivered before the Post-Graduate Conference on Industrial Medicine, American College of Physicians, Detroit, March 29, 1940.Revised for publication. Received for publication February 17, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOculoglandular Tularemia* 1 January 1943Volume 18, Issue 1Page: 72-80KeywordsFeversRabbitsTularemia ePublished: 1 December 2008 Issue Published: 1 January 1943 PDF downloadLoading ...
Clinical presentation and laboratory findings for the first autochthonous cases of dengue fever in Madeira island, Portugal, October 2012
Authors: M J Alves, P L Fernandes, F Amaro, H Osório, T Luz, P Parreira, G Andrade, L Zé-Zé, H Zeller
Journal: Eurosurveillance (2013)

An outbreak of dengue fever in Madeira island was reported in 2012. Clinical and laboratory findings of the first two laboratory-confirmed autochthonous cases are reported. Both cases had fever (≥38 °C) and petechial rash. Symptoms also included myalgia, asthenia, nausea, vomiting, anorexia, diffuse abdominal pain, and diarrhoea. The two cases were confirmed by serology and one tested positive for a dengue viral sequence. Dengue virus serotype DEN-1 was identified with probable Central or South American origin.
Abstract 13058: Liver Cirrhosis in Patients Undergoing Heart Surgery with Use of Extracorporeal Circulation: Survival Can Be Predicted by Several Preoperative Factors and Classifications
Authors: Rawa Arif, Philipp Seppelt, Simon Schwill, Dubravka Kojic, Ali Ghodsizad, Arjang Ruhparwar, Matthias Karck, Klaus Kallenbach
Journal: Circulation (2011)

Background: Empirical experiences suggest higher mortality and perioperative complication risk for patients with liver cirrhosis (LC) after cardiac surgery. However, LC is neither in euroSCORE (eS)...
Effect of race, age, and gender on prognosis in total therapy protocols for multiple myeloma.
Authors: J. Szymonifka, J. D. Shaughnessy, A. Hoering, Y. Alsayed, S. Waheed, B. P. Nair, J. Crowley, B. Barlogie
Journal: Journal of Clinical Oncology (2010)

e18502 Background: Although myeloma prognosis is dominantly affected by disease-related variables such as genetics and tumor burden, host variables have also been reported to impact outcomes. Methods: Here we are reporting on the influence on overall survival (OS) and event-free survival (EFS) of race (R; white, non-white), gender (G) and age (A) among newly diagnosed patients accrued to successive Total Therapy (TT) protocols. Vis-à-vis TT1 (n=231), TT2 (n=668) examined the role of thalidomide, and TT3 added bortezomib to thalidomide (n=303). The 3 variables, R, G, A, were forced into the multivariate model prior to its construction. Results: In the case of TT1, only A (≥65yr) affected OS adversely in multivariate analysis (HR=1.76, p=0.022), while R and G were prognosis-neutral. In TT2, control and thalidomide arms, and in TT3, none of the 3 variables affected OS or EFS independently. Both OS and EFS were dominantly by disease variables, which included cytogenetic abnormalities (CA), CRP, B2M and LDH in TT1; CA, LDH and albumin in TT2 without and CA and B2M with thalidomide; and CA, B2M and LDH in TT3. In the subsets of TT2 and TT3 with gene expression profiling (GEP) data, GEP high-risk dominated the prognostic models for both OS and EFS; while detrimental in TT2, MS molecular subgroup designation was not an adverse feature in TT3. Conclusions: We confirm the absence of independent adverse implications of advanced age, race and gender in this large sample of more than 1,200 newly diagnosed patients with myeloma. No significant financial relationships to disclose.
PROFESSIONAL ORGANIZATION.
Authors: Mark Abrahamson
Journal: JAMA (1889)

property and preserves it almost intact during the whole duration of its existence.These new char¬ acters are fixed and are easily entertained by cul¬ ture in successive generations.Thus, in consid¬ ering these types in themselves, without taking into account their origin, they may be regarded as forming one distinct species.It would not be impossible that the special types of the bacillus anthracis exist in nature with properties abso¬
Eliminating (almost) treatment dropout of substance abusing or dependent delinquents through home-based multisystemic therapy
Authors: S W Henggeler, S G Pickrel, M J Brondino, J L Crouch
Journal: American Journal of Psychiatry (1996)

This study examined the effects of an innovative treatment model that was designed to reduce treatment dropout among substance abusing or dependent juvenile offenders.One hundred eighteen delinquents who met diagnostic criteria for substance abuse or dependence were randomly assigned to receive either home-based multisystemic therapy (N=58) or treatment that was provided by the usual community services (N=60).In the multisystemic therapy condition, 98% (N=57) of the families completed a full course of treatment, which lasted an average of 130 days. In contrast, 78% (N=47) of the families assigned to treatment through the usual community services received no mental health or substance abuse treatment in the 5 months after referral.The serious and long-standing problem of high dropout rates in the substance abuse field can be greatly attenuated by services that increase accessibility and place greater responsibility for engagement on service providers.
La vésicule biliaire. Anatomie, physiologie, sémiologie, pathologie, thérapeutique.
Authors: Maurice Chiray, Ion Pavel
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Withdrawal syndrome with gradual tapering of alprazolam
Authors: Thomas A. Mellman, Thomas W. Uhde
Journal: American Journal of Psychiatry (1986)

The clinical and biological correlates of gradual alprazolam withdrawal were investigated in 10 patients in a double-blind, placebo-controlled trial. During gradual alprazolam withdrawal, anxiety and plasma cortisol levels were higher than during a postwithdrawal medication-free period.
Delays in presentation and treatment of breast cancer in Nigeria
Authors: R. E. Ezeome
Journal: Journal of Clinical Oncology (2009)

1527 Background: Programs on breast cancer prevention inresource poor countries often emphasize cost effective interventions to increase the uptake of screening, breast awareness, and the use of breast self examination. The success of such programs depends on the response of women and health professionals to the presence of symptoms of breast cancer. Understanding the factors at play in these responses is a prerequisite for strategies to shorten delays and improve stage at diagnosis. This study was designed to assess the delays and define the causes of delays in getting medical treatment by patients with breast cancer at University of Nigeria Teaching Hospital Enugu, (UNTH-E), Nigeria. Methods: A cross-sectional survey of consecutively presenting patients with breast cancer at the Surgical Oncology unit of the UNTH-E, Nigeria, was carried out between June 1999 and May 2005. A structured questionnaire was used to explore delays and the factors that influence delays in presentation and treatment of breast cancer. Results: One hundred and sixty four patients with breast cancer were interviewed. Most of them were married (71.2%), literate (84.7%), low (58.8%) or middle socioeconomic class (40%), and had access to hospitals within their area of residence. Most (81.6%) reported first for treatment at a modern health facility while 17.5% used alternative practitioners first. Twenty-six percent (42) presented within a month of noticing the symptoms while 45.3% (72) delayed for 3 months or more. In contrast, 17% (18) were seen at the site of definitive treatment within 1 month of seeking help at the initial hospital while 73.4% had a delay of more than 3 months after the initial hospital contact. Institutional or physician related delays were present in 44.5% of the cases while patient-related delays were present in 76.7% of cases. Only use of alternative practitioners as the first treatment point was significantly related to delays of more than 3 months before presentation (p = 0.029). Conclusions: For breast cancer prevention programs in Nigeria to succeed, they must, in addition to breast awareness and screening programs, address the institutional bottlenecks, the dearth of knowledge among primary care physicians, and improved referrals from alternative practitioners. No significant financial relationships to disclose.
Bibliography of the Writings of Sir William Osler, Bart., M.D., F.R.S., Regius Professor of Medicine in the University of Oxford.
Authors: Minnie Wright Blogg
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Nervous System of the Child: Its Growth and Health In Education.
Authors: Francis Warner
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Getting the run around.
Authors: Christine Kreyling
Journal: BMJ (1984)

The Tennessee Department of Transportation (TDOT) is planning to spend more than $1.25 billion on constructing Route 840, a 185-mi, four-lane-with-median ring road around metropolitan Nashville. If fully built, the highway will connect Interstates 24, 40, and 65 on both the north and south sides of the city, cutting through eight surrounding counties. Except for a small portion near Leiper's Fork in Williamson County, which is being disputed in the county's chancery court, the southern half of the road is finished or under way. The lawsuit has pitted local residents against TDOT. Opponents of the $765 million northern loop have been in the fight even longer than their southern counterparts. TDOT originally claimed 840-north would ease congestion, but their traffic analysis demonstrated a minimal impact on diverting traffic from the existing interstates and did not justify the cost. They have switched the rationale to promoting economic growth, basing their argument on the success of Interstate-285, a ring road 15 mi from the center of Atlanta, Georgia. Nashville's Chamber of Commerce has endorsed the 840 project. Until the Williamson County case is settle, both TDOT and many Nashville suburbs are in denial. A number of voices are questioning the investment logic of 840, but so far they have not been able to drive a stake through the project's heart.
Baseline Characteristics of CML Patients Accross Europe - Comparing Real-World Patients with Patient Collectives Included in Clinical Trials
Authors: Michele Baccarani, Verena Sophia Hoffmann, Gianantonio Rosti, Fausto Castagnetti, Susanne Saussele, Joelle Guilhot, Bengt Simonsson, Juan Luis Steegmann, Jiri Mayer, Karel Indrak, Anna G. Turkina, Andrey Zaritskey, Boris Labar, Irena Zupan, Noortje Thielen, Richard E. Clark, Josef Thaler, Frederiki Melanthiou, Hele Everaus, Kimmo Porkka, Andrija Bogdanovic, Gabriele Schubert-Fritschle, Panagiotis Panagiotidis, Tamas Masszi, Sandra Lejniece, Laimonas Griskevicius, Andrzej Hellmann, Witold Prejzner, Tomasz Sacha, Antonio Almeida, Irina Dyagil, Adriana Colita, Georgi G. Mihaylov, Rüdiger Hehlmann, Joerg Hasford, Doris Lindoerfer
Journal: Blood (2014)
Abstract 16499: Preamyloid Oligomers are Present in Human Atrium and Are Associated With Post-Operative Atrial Fibrillation
Authors: Lisa C Mace, Liudmila V Yermalitskaya, John G Byrne, Michael R Petracek, James P Greelish, Steven J Hoff, Stephen K Ball, Sam Wells, Charles G Glabe, Carol A Meisch, Carol N Bowling, Lisa L Murphy, James B Atkinson, Daniel W Byrne, Joey V Barnett, Nancy J Brown, Katherine T Murray
Journal: Circulation (2011)

The basic pathophysiology of atrial fibrillation (AF) remains poorly understood. In a cellular model of AF, we observed transcriptional upregulation of proteins implicated in amyloidosis, a patholo...