tbuckley/cabot-search huggingface dataset:
Abstract Su1207: Influence of Duration of Device-based Fever Prevention on Inflammation, Vasopressor Usage, and Oxygen Consumption after Cardiac Arrest - a Substudy of a Randomized Controlled Trial
Authors: Martin Meyer, Rasmus Beske, Simon Molstrom, Johannes Grand, Simon Schneekloth, Laust Emil Roelsgaard Obling, Jacob Moller, henrik Schmidt, Jesper Kjaergaard, Christian Hassager
Journal: Circulation (2024)

Background: In the post-resuscitation phase, cardiac arrest patients develop a systemic inflammatory response and fever is likely if not actively treated. The Blood Pressure and Oxygenation Targets after Out-of-hospital Cardiac Arrest (BOX) trial, randomized patients to a total duration of device-based fever prevention for 36 or 72 hours. The trial found no differences in mortality or neurologic outcome. Use of device-based fever prevention for a shorter or longer duration could however result in clinically relevant differences in the magnitude of inflammation, vasopressor usage, and oxygen consumption. Aim: To assess the effect of a shorter or longer duration of device-based fever prevention on inflammation, vasopressor usage, and oxygen consumption in the intervention period from 36 to 72 hours. Methods: The BOX trail [NCT03141099] randomized comatose resuscitated out-of-hospital cardiac arrest (OHCA) patients to three different treatment targets in the post-resuscitation phase: mean arterial blood pressure target of 63 or 77mmHg; oxygenation targets of 68-75 or 98-105 mmHg; and duration of device-based fever prevention in comatose patients for a total of 36 or 72 hours. Endpoints at 48 and 72 hours: leukocytes; CRP; vasoactive-inotropic score (VIS); systemic oxygen consumption determined by use of Fick’s principle. Analyses were performed both on the total BOX population, and for a sensitivity analysis, selectively on patients still comatose at 72 hours (i.e., not awake or dead) as these had the most exposure to the intervention. Results: The total population consists of 789 patients, with 393 and 396 randomized to a total duration of device-based fever prevention for 36 and 72 hours respectively. For the analysis of patients still comatose at 72 hours, 122 and 148 were available for analysis in the 36-hour and 72-hour group respectively. There were no differences between the 36- and 72-hour group for leukocytes, CRP, VIS, or oxygen consumption during the intervention period from 36 until 72 hours, neither for the total population (Figure 1, all p&gt;0.05) or the cohort of patients still comatose at 72 hours (Figure 2, all p&gt;0.05). Conclusions: There were no group differences for patients randomized to device-based fever prevention for 36 or 72 hours with respect to the magnitude of inflammation, vasopressor usage, or oxygen consumption. These findings were consistent for the cohort as a whole, and when examining those with most exposure to the intervention.
Abstract Su406: Acceptability and Effectiveness of a Novel, Video-Based CPR and AED Education Program in Canadian Schools
Authors: Katherine Allan, Holly McCulloch, Kim Ruether, Jeanine Zotzman, Ian Blanchard, Mike Janczyszyn, Natalie Wong, Emma ONeil, John Sapp, Santokh DHILLON
Journal: Circulation (2024)

Background: Early cardiopulmonary resuscitation (CPR) and defibrillation are critical for favorable outcomes after sudden cardiac arrest (SCA). Scientific evidence supports CPR and Automated External Defibrillator (AED) training in school-age children. Few studies have used gamified, video-based training to teach students. This national project aimed to assess the acceptability and effectiveness of a brief, video-based educational program (CardiacCrash™), developed by the Heart and Stroke Foundation to teach students hands-only CPR and AED use within a classroom setting. Methods/Results: This study reports preliminary data from two Canadian provinces (Ontario, Alberta). The acceptability and effectiveness of training was measured using a pre/post survey evaluating students’ self-confidence in recognizing SCA, calling for help, and providing bystander CPR, including the use of an AED. CPR performance was measured by using Little Anne QCPR manikins that collected data on CPR effectiveness throughout the training session. Results are stratified by student cohort (elementary—grades 4-8, and secondary—grades 9-12). A total of 1273 students from 6 Ontario and 7 Alberta schools were trained between October 2023 to April 2024. The average age for elementary students (n=729; 47.3% male) was 11.2 ± 1.3 years, and 39.9% had previous CPR training. The average age for secondary students (n=544; 54.4% male) was 15.5 ± 1.1, and 42.6% had previous CPR training. Both groups thought the training was easy (86%), fun (81%), the correct duration (59%) and would recommend it to their friends (85%). All outcome variables improved post-training for both elementary and secondary students, including the self-confidence to recognize and assist in cases of SCA (p=0.008 for both cohorts), (Figure 1). Secondary students were significantly better at providing effective compressions vs. elementary for most CPR measures (Table 2). Conclusion: Preliminary data suggest that CardiacCrash™, a video-based educational program, is acceptable to school-age students and effective at teaching them to perform CPR and use an AED. While both elementary and secondary students achieved acceptable CPR performance, secondary students performed higher quality CPR.
Abstract Su907: Post-Cardiac Arrest Potassium Abnormalities Associated With Unfavorable Functional Outcome
Authors: Aki Holm, Jean Baptiste Lascarrou, Alain Cariou, Matti Reinikainen, Timo Laitio, Hans Kirkegaard, ELDAR SOREIDE, Fabio Silvio Taccone, Markus Skrifvars
Journal: Circulation (2024)

Background: Abnormal potassium levels are common findings in the intensive care unit (ICU) population. We aimed to determine the incidence of dyskalemias at ICU admission and their association with functional outcome in comatose patients resuscitated from cardiac arrest. Hypothesis: We hypothesized that both hypokalemia and hyperkalemia are associated with unfavorable functional outcome. Methods: Pooled data from four randomized clinical trials in comatose post-cardiac arrest patients admitted to ICU after return of spontaneous circulation (ROSC). Reference potassium levels were defined as between 3 and 4.9 mmol/L, as proposed in the Simplified Acute Physiology Score II. Favorable functional outcome was defined as a Cerebral Performance Category of 1 or 2 at 180 days. Results: We included 1133 patients (557 from HYPERION, 346 from TTH48, 120 from COMACARE and 110 from Xe-HYPOTHECA) with a median age of 64 (IQR: 55-72) years and a predominance of males (72%). Overall, 421 (36%) patients had favorable functional outcome. On admission, 221 (19.5%) patients experienced hyperkalemia and 35 (3.1%) patients experienced hypokalemia. More patients in the normokalemia group (364/877, 41.5%) had a favorable functional outcome, as compared to the hypokalemia (11/35, 31.4%) and hyperkalemia (41/221, 18.6%) groups p&lt;0.001). In a mixed-effects logistic regression model including initial rhythm, delay from collapse to ROSC, bystander cardiopulmonary resuscitation, lactate, and urea and with normokalemia as reference group, hyperkalemia was associated with higher odds for unfavorable functional outcome (OR 1.85, 95% CI 1.10-3.12, p=0.02) whereas hypokalemia was not (OR 1.36 95% CI 0.51-3.60, p=0.53). Conclusions: One fifth of unconscious cardiac arrest patients experienced dyskalemia on ICU admission. Hyperkalemia was associated with unfavorable functional outcome at 180 days compared to normokalemia, whereas hypokalemia was not an independent predictor of outcome.
Abstract Su506: A Comparison of Synchronized Versus Unsynchronized Mechanical Chest Compressions in a Swine Model
Authors: Keith Marill, James Menegazzi, Jorge Gumucio, David Salcido
Journal: Circulation (2024)

Background: The proportion of cardiac arrest presenting with pulseless electrical activity (PEA), which includes pseudo-PEA, is increasing and survival remains dismal. We hypothesized that mechanical chest compressions synchronized to native cardiac contractions improve coronary perfusion pressure (CPP) during resuscitation of pseudo-PEA. Methods: We developed a model of pseudo-PEA by infusing high dose esmolol intravenously into anaesthetized, intubated, and central arterial and venous catheterized swine to a goal of 45 mm Hg mean arterial blood pressure (MAP). We then provided alternating synchronized and unsynchronized chest compressions for 52 seconds preceded by 8 second breaks consecutively four times. We repeated the protocol two to three times with one minute breaks after each four minute block. Synchronized compressions were provided 1:1 with native contractions during systole and unsynchronized compressions were provided at 100 beats per minute (BPM). We measured average CPP, MAP, and heartrate (HR) for 5 beats immediately preceding the onset of chest compressions and for 30 seconds 10 seconds after the onset of compressions. We computed the difference in continuous CPP during compressions compared to the immediately preceding baseline for each interval. We developed a mixed linear model with outcome variable average CPP during compressions minus baseline, fixed variable compression type, and random variable animal. Results: We included four animals. Mean baseline HR was 78.9 BPM, MAP 55.2, and CPP 44.0. Chest compressions increased CPP from baseline an average 4.0 mm Hg when unsynchronized and 6.4 mm Hg synchronized. The adjusted difference was 2.5 mm Hg (95% CI 0.3 – 4.6). Conclusions: Synchronized chest compressions significantly increased CPP 2.5 mm Hg (62%) more than unsynchronized chest compressions despite a lower compression rate in a medication-induced swine model of pseudo-PEA. Further refinement and application to patients suffering pseudo-PEA cardiac arrest appear warranted.
Abstract Su404: Time difference between pad placement in double versus single external defibrillation: a live patient simulation model
Authors: Vegard Nordviste, Andreas Kruger, Marius Rehn, Jostein Brede
Journal: Circulation (2024)

Background: Out-of-hospital cardiac arrest (OHCA) cause significant patient morbidity and mortality. Double sequential external defibrillation (DSED) represents an alternative treatment for OHCA patients, but the use is currently reserved for patients in refractory ventricular fibrillation. However, OHCA patients may achieve return of spontaneous circulation earlier with the use of DSED as the initial treatment. Aims: To compare the necessary times needed to establish pad placement in DSED compared to standard pad placement in a live patient simulation model. Methods: This study was an observational cohort study with ambulance personnel and live patient models. Two-member teams established two defibrillators ready for rhythm analysis. Time spent for standard pad placement and DSED was registered in the same procedure. The procedure was performed on two patient categories, with BMI 20,9 (patient A) and BMI 32,8 (patient B). All team members performed the procedure on both patient categories. Results: In total, 108 procedures were performed on both patient categories. Mean difference in time needed for DSED versus standard pad placement was 13.7 ± 4.8 seconds for patient A, and 13.9 ± 4.6 seconds for patient B. There was no significant difference in time spent between the two patient categories (p=0.725). Conclusion: The necessary time to establish DSED versus standard defibrillation pad placement was short. This may support clinical studies on DSED as initial treatment for OHCA patients without risk of significant increase in time to first defibrillation.
Abstract Su901: Association of Hemoglobin and Partial Pressure of Oxygen in Arterial Blood on Survival and Neurologic Outcomes in In-Hospital Cardiac Arrest Patients
Authors: Rudra Koul, Vasu Gupta, Nasheeta Qadeer, Jignesh Patel
Journal: Circulation (2024)

Background: Lower hemoglobin levels have been associated with poor outcomes in patients with out-of-hospital cardiac arrests. Pre-arrest hemoglobin (within 24 hours) and its association with outcomes and PaO2 in in-hospital cardiac arrest (IHCA) remains unknown. We aimed to evaluate the association of pre-arrest hemoglobin levels with survival and neurologic outcomes, and intra-arrest PaO2 levels in adults with IHCA. Methods: The study population included adults with IHCA undergoing resuscitation at an academic tertiary medical center from 2011-2019. Hemoglobin levels were obtained within 24 hours prior to arrest, and PaO2 levels were obtained intra-arrest via arterial blood gas samples. Patients were classified based upon three pre-arrest hemoglobin (Hgb) levels: Hgb &lt; 8.5, Hgb 8.5-10.5, Hgb &gt; 10.5. Return of spontaneous circulation (ROSC), survival to discharge, favorable neurological outcome (defined as a Glasgow Outcome Score of 4-5), and association with PaO2 served as outcomes of interest. Results: Of the 799 patients studied, 493 patients had pre-arrest hemoglobin data and 164 had intra-arrest PaO2 data. Of those patients that had pre-arrest hemoglobin data, 145 (29.4%) had Hgb &lt; 8.5, 178 (36.1%) had Hgb 8.5-10.5, 170 (34.5%) had Hgb &gt;10.5. Charlson Comorbidity Score was similar across each hemoglobin group. Most patients had PEA/Asystole as the initial rhythm at onset of cardiac arrest, and the number was similar across each hemoglobin group. Mean intra-arrest PaO2 was higher in the Hgb &lt; 8.5 group. Compared to Hgb &lt; 8.5, higher hemoglobin levels were associated with higher rates of ROSC in both univariate (Hgb &lt; 8.5: 46.9% vs. Hgb 8.5-10.5: 59.6% vs. Hgb &gt; 10.5: 62.9%, p = 0.012) and multivariate (Hgb 8.5-10.5: OR 1.51, 95% CI 0.96-2.39; Hgb &gt; 10.5: OR 1.75, 95% CI 1.10-2.79) analyses. Higher hemoglobin levels were associated with higher rates of favorable neurologic outcome in the univariate analysis only (Hgb &lt; 8.5: 10.5% vs. Hgb 8.5-10.5: 11.8% vs. Hgb &gt; 10.5: 19.4%, p = 0.043). There was no significant correlation between pre-arrest hemoglobin and intra-arrest PaO2. Conclusions: In this contemporary registry of adults with IHCA, higher hemoglobin values were associated with higher rates of ROSC. There may be an association between higher hemoglobin levels and favorable neurologic outcome. There was no association between pre-arrest hemoglobin and intra-arrest PaO2.
Abstract Su402: Comprehensive Assessment of Chest Compression Quality Across All Phases of Prehospital Care Using a Manikin
Authors: KENSUKE FUJITA, Eri Douno, Hiroaki Hanafusa, Akira Inoue, Yoshihiro Hagiwara, Takayuki Ogura
Journal: Circulation (2024)

Background: High-quality cardiopulmonary resuscitation (CPR) is crucial for improving the prognosis of out-of-hospital cardiac arrest (OHCA) patients. The quality of chest compressions may vary during different phases of prehospital care. Objectives: To investigate changes in chest compression quality during prehospital activities and identify the causes. Methods: Eleven emergency medical teams of three members each participated. Using a manikin (Laerdal QCPR), we measured achievement rates of compression depth (≥5 cm) and recoil, compression rate, and chest compression fraction (CCF). The process from the scene to the hospital bed was divided into four phases: 1) on-site, 2) transport from the scene to the ambulance (canvas stretcher), 3) in the ambulance, 4) transport from the ambulance to the hospital bed (wheeled stretcher). We analyzed the quality changes in chest compressions and the causes of degradation or interruptions. Each team performed both manual CPR (Man-CPR) and mechanical CPR (Mech-CPR) using the LUCAS3 device. The scenario assumed cardiac arrest on the second floor, transport down stairs to the ambulance, and a 15-minute drive to the hospital. ACLS was established in Phase 1 and continued until hospital arrival. In Mech-CPR, a mechanical CPR device was applied in Phase 1 and used throughout all phases. Results: Man-CPR showed lower compression depth achievement in Phases 2 and 4 compared to Phases 1 and 3, mainly due to transport transitions (Fig. 1). CCF was high in Phases 1 and 3 but decreased in Phases 2 and 4 due to these transitions. Interruptions in Phases 1 and 3 were due to checking ECG rhythm, securing an airway, and confirming ventilation. Recoil achievement was low across all phases. Mech-CPR showed high achievement rates for compression depth and recoil across all phases and maintained high CCF. However, Man-CPR had a higher CCF in Phase 1 than Mech-CPR due to interruptions for device application. Mech-CPR had no degradation due to dual work, but improper application caused long degradations and interruptions. The longest interruption times were 69 seconds (transport) for Man-CPR and 25 seconds (device application) for Mech-CPR. Both Man-CPR and Mech-CPR maintained compression rates within the guideline range of 100-120/min, with Man-CPR tending to be faster. Conclusion: Chest compression quality varies from the scene to hospital arrival. Man-CPR and Mech-CPR have different causes of quality changes and interruptions.
Abstract Su303: Afferent Rapid Response Limb Failure Prior to Non-ICU In-Hospital Cardiac Arrest and Associated In-Hospital Mortality
Authors: Kipp Shipley, Megan Shifrin, Connor Snarskis, Liza Weavind
Journal: Circulation (2024)

Introduction/Background: Rapid Response Teams (RRT) have been widely implemented to recognize and manage clinical deterioration outside of the intensive care unit (ICU). Hospital systems frequently rely on individual healthcare provider’s skill and attention to identify early deterioration and activate the appropriate clinical resources. This is referred to as the afferent limb, or triggering mechanism, of the Rapid Response system. Hypothesis: Afferent limb failure leads to delayed clinical intervention and potentially worse outcomes for patients that progress to in-hospital cardiac arrest (IHCA). Goals/Aims: The aim of this retrospective study was to identify if afferent limb failure, defined as failure to recognize two or more standardized early warning criteria in the 24 hours prior to non-ICU IHCA, is associated with increased in-hospital mortality when compared to patients with zero to one standardized early warning criteria. Methods: Non-ICU IHCAs over a 6-year period (January 1 st , 2018, to December 31 st , 2023) at a large academic medical center were reviewed using standardized criteria to determine 1) if any RRT activation criteria had been met in the 24 hours prior to non-ICU IHCA, 2) how many RRT criteria were met, 3) whether an RRT activation occurred, and 4) in-hospital mortality. Statistical analysis included a Chi-Square analysis and Pearson Correlation Coefficient. Results: We identified 386 adult non-ICU IHCAs, with 214 (55.4%) meeting at least two RRT criteria in the 24 hours preceding their non-ICU IHCA. In patients without a preceding RRT activation (N=313), there was significantly higher in-hospital mortality in patients who met two or more RRT criteria prior to their non-ICU IHCA than patients who met one or zero criteria (91/151, 60.2% vs 114/162, 70.3%, p &lt; 0.05). We also found a weak but statistically significant correlation between the total number of RRT criteria met prior to IHCA and in-hospital mortality (r=0.1331, p &lt; 0.05). Conclusion: Afferent limb failure is associated with higher in-hospital mortality in patients with multiple markers of clinical deterioration prior to non-ICU IHCA. There is also an association between in-hospital mortality and the total number of clinical deterioration criteria met prior to non-ICU IHCA.
Abstract Su703: Racial/Ethnic Disparities in Bystander Cardiopulmonary Resuscitation after Witnessed Out-of-Hospital Cardiac Arrest: A NEMSIS Database Study
Authors: Danielle Lee, Katherine Couturier, Amelia Breyre, Alexander Nelson, Charles Ingram, Sarah Perman, David Yang
Journal: Circulation (2024)

Introduction: Out of hospital cardiac arrest (OHCA) is a leading cause of death in the United States, with upwards of 360,000 OHCAs annually. Receiving bystander cardiopulmonary resuscitation (CPR) almost doubles an individual’s odds of survival compared to those who don’t receive bystander CPR. Unfortunately, in the US, bystander application of CPR only occurs in 40% of OHCA. Improving the rate of bystander CPR and AED use will improve survival rates for OHCA. Minoritized populations experience worse outcomes from OHCA. Compared to non-Hispanic whites, they are less likely to survive to hospital discharge. A cross-sectional study of witnessed OHCA patients found that Black and Hispanic patients had lower rates of bystander CPR. Less is known about disparities in care for Asian American persons who experience OHCA. Studies using the Resuscitation Outcomes Consortium Epidemiologic Registry (ROC) and the Cardiac Arrest Registry to Enhance Survival (CARES) have concluded discrepant results, with ROC finding that Asian Americans were less likely to receive bystander CPR and CARES finding that they were just as likely to receive bystander CPR compared to non-Hispanic Whites. To that end, we sought to evaluate the association between bystander CPR and Asian race after witnessed OHCA. Objective: To evaluate the association between race/ethnicity and the odds of receiving bystander cardiopulmonary resuscitation (bCPR) after witnessed out-of-hospital cardiac arrest (OHCA). Methods: Data were obtained from the National Emergency Medical Services Information System (NEMSIS) database for adults (≥18 years) with a witnessed non-traumatic OHCA in the year 2022. Patients were separated into two groups: Non-Hispanic White and Asians. The primary outcome was the odds of receiving bCPR. Exclusions included traumatic etiology, do-not-resuscitate orders, and arrests witnessed by healthcare providers. Pearson’s chi-square test was used to test significance. Results: A total of 73,215 witnessed OHCA activations were included in this study. Overall, bystander CPR rates were lower for the Asian group (59.8%) compared to the Non-Hispanic White group (65.0%). Pearson’s chi-square test showed a statistically significant difference between the bCPR rates of the Asian group and Non-Hispanic White group, with a p-value of less than 0.001. Conclusion: Racial/ethnic disparities exist for Asian individuals in the odds of receiving bCPR after a witnessed non-traumatic OHCA.