tbuckley/cabot-search huggingface dataset:
PD-1 blockade immunotherapy as a successful rescue treatment for disseminated adenovirus infection after allogeneic hematopoietic stem cell transplantation
Authors: Fei Zhou, Feng Du, Ziyan Wang, Mengxing Xue, Depei Wu, Suning Chen, Xuefeng He
Journal: Journal of Hematology & Oncology (2024)

Abstract Disseminated adenovirus infection is a complication with a relatively high mortality rate among patients undergoing hematopoietic stem cell transplantation. The low efficacy and poor availability of current treatment options are of major concern. Programmed cell death 1 (PD-1) blockade has been used to treat several chronic viral infections. Herein, we report a case of disseminated adenovirus infection in the early posttransplant period. The patient was diagnosed with diffuse large B-cell lymphoma at first and underwent 8 cycles of chemotherapy, including rituximab. She was subsequently diagnosed with acute myeloid leukemia and received haploidentical transplantation. She was diagnosed with Epstein‒Barr virus (EBV)-positive posttransplant lymphoproliferative disorder (PTLD) 2 months after the transplant, and 3 doses of rituximab were administered. The patient was diagnosed with disseminated adenovirus infection with upper respiratory tract, gastrointestinal tract and blood involved at 3 months after transplantation. She was first treated with a reduction in immunosuppression, cidofovir and ribavirin. Then, the patient received salvage treatment with the PD-1 inhibitor sintilimab (200 mg) after achieving no response to conventional therapy. The adenovirus was cleared 3 weeks later, and concomitant EBV was also cleared. Although the patient developed graft-versus-host disease of the liver after the administration of the PD-1 inhibitor, she was cured with steroid-free therapy. Therefore, PD-1 blockade immunotherapy can be considered a promising treatment option for patients with disseminated adenovirus infection after transplantation, with fully weighing the hazards of infection and the side effects of this therapy.
Generation of sarconoids from angiosarcoma patients as a systematic-based rational approach to treatment
Authors: Da Jung Jung, Jae Hee Byeon, Young Chul Kim, Woo Shik Jeong, Jong-Woo Choi, Gi Seok Jeong
Journal: Journal of Hematology & Oncology (2024)

Abstract Angiosarcoma is a rare subtype of malignant neoplasm originating from vascular or lymphatic endothelial cells; its low incidence has posed significant challenges for comprehensive investigations into its pathogenic mechanisms and the development of innovative treatment modalities through in vitro and in vivo models. Recent endeavors spearheaded by patient-partnered research initiatives have aimed to elucidate the intricacies of angiosarcomas by leveraging biological omics approaches, with the overarching objective of enhancing prognostic indicators and therapeutic options for this uncommon pathology. To bridge the gap between preclinical research and translational applications, we engineered angiosarcoma-derived organoids from surgically resected primary tumors, hereafter referred to as “sarconoids,” as a proof-of-concept model. A novel protocol for the establishment of these sarconoids has been developed and validated. To ensure that the sarconoids faithfully recapitulate the heterogeneity and complexities of the patients’ original tumors, including transcriptomic signatures, cell-type specificity, and morphological traits, exhaustive histological and transcriptomic analyses were conducted. Subsequently, we expanded the scope of our study to include an evaluation of a sarconoid-based drug screening platform; for this purpose, a drug library (AOD IX), supplied by the National Cancer Institute’s Developmental Therapeutics Program, was screened using 96-well plates. Our findings suggest that sarconoids can be reliably generated from angiosarcoma patient-derived tissues and can serve as accurate models for evaluating therapeutic responses, thereby holding far-reaching implications for translational research and clinical applications aimed at advancing our understanding and treatment of angiosarcoma.
Abstract P62: Derangements in Blood Glucose Following Initial Resuscitation from In-Hospital Cardiac Arrest: <i>A Report from the American Heart Association National Registry of Cardiopulmonary Resuscitation</i>
Authors: David G Beiser, Gordon E Carr, Dana P Edelson, Mary A Peberdy, Terry L Vanden Hoek
Journal: Circulation (2008)

BACKGROUND: Hyperglycemia is associated with poor outcomes in a variety of critically-ill patient populations; however, little is known about the role of hyperglycemia in determining outcomes following in-hospital cardiac arrest (IHCA). METHODS: We performed a retrospective analysis of 17,800 adult in-hospital cardiac arrests from the National Registry of Cardiopulmonary Resuscitation. Minimum and maximum blood glucose values during the first 24 hours following return of spontaneous circulation (ROSC) were examined. RESULTS: Glucose data from 3,226 patients were available for analysis. Post-ROSC maximum blood glucose values were markedly elevated in diabetic (median, 226 mg/dL, [IQR, 165 – 307 mg/dL)] as well as non-diabetic patients (176 mg/dL, 135 – 239 mg/dL). Survival to hospital discharge was higher in non-diabetics than diabetics (45.5% [95% CI, 43.3 – 47.6%] vs. 41.7% [95% CI, 38.9 –44.5%], p = 0.037). In non-diabetics, survival to hospital discharge varied significantly when stratified by glucose value with optimal survival odds occurring across a broad range of minimum (71 – 170 mg/dL) and maximum (111 – 240 mg/dL) glucose values. Cardiac arrest duration quartile was identified as a significant factor associated with the development of post-ROSC hypo- and hyperglycemia in non-diabetics. CONCLUSIONS: Derangements in blood glucose are common following IHCA in both diabetic and non-diabetic patients. Optimal survival odds occur across a relatively broad range of glucose values in non-diabetics; however, both hypo- and hyperglycemia are associated with worse outcomes and associated with longer arrest durations.
Validity of routine surveillance data: a case study on Swedish notifications of methicillin-resistant Staphylococcus aureus
Authors: M Stenhem, Å Örtqvist, H Ringberg, L Larsson, B Olsson-Liljequist, S Hæggman, M Kalin, K Ekdahl, None the Swedish study group on MRSA epidemiology
Journal: Eurosurveillance (2009)

Surveillance of communicable diseases is a public health corner stone. Routine notification data on communicable diseases are used as a basis for public health action as well as for policy making. While there are agreed standards for evaluating the performance of surveillance systems, it is rarely possible to analyse the validity of the data entered into these systems. In this study we compared data on all Swedish cases of methicillin-resistant Staphylococcus aureus (MRSA) routinely notified between 2000 and 2003 with follow-up information collected for each of these cases as part of a public health project. The variables Reason for testing (clinical sample, contact tracing, screening of risk group), Clinical presentation (disease, colonisation), Transmission setting (healthcare-acquired, community-acquired), Country of acquisition (Sweden, abroad) and Risk-occupation (yes, no) were analysed for sensitivity, positive predictive value and completeness of answers. The sensitivity varied between 23% and 83%, the positive predictive values were generally higher (55% to 97%), while missing answers varied from 11% to 59%. The proportion of community-acquired cases was markedly higher when excluding either cases of MRSA colonisation or cases found through public health-initiated activities (contact tracing or screening of risk groups). We conclude that the quality of routine surveillance data may be inadequate for in-depth epidemiological analyses. This should be taken into account when interpreting routine surveillance figures. Whether or not the case definition includes cases of MRSA colonisation may have a significant impact on population-wide estimates of MRSA occurrence.
Hepatic artery restriction operation combined with ALPPS (HARO-ALPPS), a novel ALPPS procedure for the treatment of hepatocellular carcinoma with severe fibrosis: Retrospective clinical cohort study
Authors: Zhang Wen, Zongrui Jin, Banghao Xu, Hai Zhu, Jilong Wang, Weitao Chen, Jianyong Zhang, Keyu Huang, Zhujing Lan, Bingcheng Meng, Weimin Mao, Huaitao Zhu, Ling Zhang, Tingting Lu, Jingjing Zeng, Li Bao, Wan Ye Lau, Ya Guo
Journal: International Journal of Surgery (2024)

Background: Associating liver partition with portal vein ligation for staged liver resection (ALPPS) has been used in the treatment of patients with advanced or massive liver cancer without sufficient future liver remnant, but concerns remain regarding tumor outcomes and surgical safety. This study aims to evaluate the efficacy and safety of a new procedure, hepatic artery restriction operation combined with ALPPS (HARO-ALPPS), in the treatment of hepatocellular carcinoma (HCC) patients especially with severe fibrosis. Methods: This retrospective study analyzed 8 patients who underwent HARO-ALPPS for HCC and compared their outcomes with 64 patients who underwent conventional ALPPS. The primary outcomes assessed were liver regeneration ability (measured by relative and absolute kinetic growth rates), postoperative complications, and mortality. The secondary outcomes included overall survival and disease-free survival. Results: HARO-ALPPS significantly restricted the blood supply of the hepatic artery. One week after surgery, the blood flow of the right hepatic artery dropped to 62.1%. At the same time, HARO-ALPPS shows superior liver regeneration ability, which is particularly prominent in the background of liver fibrosis. No serious complications occurred after HARO-ALPPS. The overall survival rate of HARO-ALPPS was 75%, which was higher than that of ALPPS (64%, P =0.816). Conclusion: Compared to conventional ALPPS, HARO-ALPPS exhibits a better liver regeneration ability, and favorable long-term outcomes. Further prospective studies are needed to validate these findings and evaluate the long-term oncologic outcomes of this novel procedure.
Rising sun or strangled in the cradle？A narrative review of near-infrared fluorescence imaging-guided surgery for pancreatic tumors
Authors: Kang Chen, Xiong Teng, Ning Zhou, Wei Cheng
Journal: International Journal of Surgery (2024)

Near-infrared fluorescence (NIRF)-guided surgical navigation has become a promising and effective detection method in pancreatic tumor surgery. The imaging technique has gradually transitioned from the NIR-I region to the NIR-II region. Real-time assessment of the tumor boundary and determination of the ideal resection plane are essential for preserving the pancreatic parenchyma and its secretory functions. However, since the pancreatic parenchyma has a less rich blood supply than the liver, the application of contrast agents in pancreatic tumor surgery is still in its infancy. The application of indocyanine green (ICG) and methylene blue (MB) in intraoperative NIRF imaging of pancreatic tumors has become more mature, but due to the characteristics of non-specific imaging, the imaging efficiency and depth need to be improved. Many tumor-specific imaging agents have been designed, but most of them have not gone past animal trials because of their high development and imaging costs, biotoxicity, and other limitations. In this article, we review recent reports of ICG, MB and newly developed contrast agents and imaging devices. We focus on the current status and new developments in the application of these contrast agents and summarize the current clinical and preclinical studies on specific contrast agents. We synthesize relevant reports to discuss the difficulties and prospects of the application of fluorescent imaging agents in pancreatic tumors. We hope that reviewing previous studies and the current progress on contrast imaging technology will provide new perspectives for its future application and development in pancreatic tumor surgery, which should translate into better patient prognoses. The manuscript was written according to the Scale for the Assessment of Narrative Review Articles (SANRA).
Letter to the Editor: focusing on the prevention and secondary brain injury of traumatic brain injury: a heavy challenge for the brain
Authors: Lingjia Xu, Yunyun Pan
Journal: International Journal of Surgery (2024)

aDepartment of Neurology, Shaoxing Second Hospital, Shaoxing, Zhejiang, 312000, China bDepartment of Emergency Internal Medicine, Shaoxing Second Hospital, Shaoxing, Zhejiang, 312000, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Emergency Internal Medicine, Shaoxing Second Hospital, Shaoxing, Zhejiang, 312000, China. E-mail address: [email protected] (Y. Pan). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Association between daily sitting time and kidney stones based on the National Health and Nutrition Examination Survey (NHANES) 2007-2016: A cross-sectional study
Authors: Ya Li, Xingpeng Di, Mengzhu Liu, Jingwen Wei, Tianyue Li, Banghua Liao
Journal: International Journal of Surgery (2024)

Kidney stones are among the most common urological conditions affecting ~9% of the world population. Although some unhealthy diets and unhealthy lifestyles are reportedly risk factors for kidney stone, the association between daily sitting time and kidney stone has not been explored.
Letter to editor: “identification of patients with favorable prognosis after resection in intermediate-stage hepatocellular carcinoma”
Authors: You-Jian Xu, Hui-Ming Pang
Journal: International Journal of Surgery (2024)

Department of General Surgery,Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People's Hospital), Hangzhou Medical College,Taizhou, Zhejiang, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Tiantai People's Hospital of Zhejiang Province: Tiantai Hospital of Hangzhou Medical College CHINA. E-mail address: [email protected] This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Enhancing the validity of mortality prediction models in orthopedic surgery: two critical evaluations
Authors: Xianghong Guo, Ya Yang, Jingling Luo
Journal: International Journal of Surgery (2024)

aDepartment of Orthopedics, Qujing Second People's Hospital, Qujing Central Hospital of Yunnan Regional Medical Center, Qujing, China bDepartment of Gastroenterology, Qujing Second People's Hospital, Qujing Central Hospital of Yunnan Regional Medical Center, Qujing, China Xianghong Guo and Ya Yang contributions equal to this article. The data that support the findings of this study are available on request from the corresponding author, Jingling Luo, upon reasonable request. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding AuthorAddress: Department of Orthopedics, Qujing Second People's Hospital, Qujing Central Hospital of Yunnan Regional Medical Center, Qujing, China. No. 289, Qilin West Road, Qilin District, Qujing City, Yunnan Province, China, Tel:+8615887479633. E-mail address: [email protected] (J. Luo). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Letter to the editor for the article“From early risk to 1-year mortality: a comprehensive assessment of postoperative venous thromboembolism in upper gastrointestinal cancer patients - a nationwide cohort study”
Authors: Weinin Fan, Lexin Wang, Kexin chen, Hao Chi
Journal: International Journal of Surgery (2024)

aGeneral Hospital of Ningxia Medical University, Yinchuan, Ningxia 750000, China bNingxia Medical University, Yinchuan, Ningxia 750000, China cClinical Medical College, Southwest Medical University, Luzhou 646000, China Assistance with the study: none. Financial support and sponsorship: none. Weinin Fan, Lexin Wang, Kexin chen These authors have contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Clinical Medical College, Southwest Medical University, Luzhou 646000, China. E-mail address: [email protected] (H. Chi). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Association Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined Significance
Authors: Ingigerdur Sverrisdottir, Sigrun Thorsteinsdottir, Sæmundur Rognvaldsson, Thor Aspelund, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni A. Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdóttir, Signy Vala Sveinsdottir, Robert Palmason, Isleifur Olafsson, Fridbjorn Sigurdsson, Asdis Rosa Thordardóttir, Elias Eythorsson, Asbjorn Jonsson, Runolfur Palsson, Olafur Skuli Indridason, Gauti Kjartan Gislason, Andri Olafsson, Jon Sigurdsson, Hlif Steingrímsdóttir, Thorir Einarsson Long, Malin Hultcrantz, Brian G.M. Durie, Stephen Harding, Ola Landgren, Sigurdur Yngvi Kristinsson, Thorvardur Jon Love
Journal: Annals of Internal Medicine (2024)

Monoclonal gammopathy of undetermined significance (MGUS) is a precursor of multiple myeloma (MM) and related conditions. In previous registry-based, retrospective studies, autoimmune diseases have been associated with MGUS. However, these studies were not based on a screened population and are therefore prone to ascertainment bias.
Comparison of LA Grades of Erosive Esophagitis Scored by Local Investigators vs Central Adjudicators in a Clinical Trial
Authors: Stuart J. Spechler, Loren Laine, Kenneth R. DeVault, Azmi Nabulsi, Barbara Hunt, Philip Katz
Journal: Clinical Gastroenterology and Hepatology (2024)

Approximately 30% of patients with typical gastroesophageal reflux disease (GERD) symptoms have endoscopic evidence of erosive esophagitis (EE).
Computer-Aided Diagnosis for Leaving Colorectal Polyps In Situ
Authors: Cesare Hassan, Masashi Misawa, Tommy Rizkala, Yuichi Mori, Shahnaz Sultan, Antonio Facciorusso, Giulio Antonelli, Marco Spadaccini, Britt B.S.L. Houwen, Emanuele Rondonotti, Harsh Patel, Kareem Khalaf, James Weiquan Li, Gloria M. Fernandez, Pradeep Bhandari, Evelien Dekker, Seth Gross, Tyler Berzin, Per Olav Vandvik, Loredana Correale, Shin-ei Kudo, Prateek Sharma, Douglas K. Rex, Alessandro Repici, Farid Foroutan
Journal: Annals of Internal Medicine (2024)

Computer-aided diagnosis (CADx) allows prediction of polyp histology during colonoscopy, which may reduce unnecessary removal of nonneoplastic polyps. However, the potential benefits and harms of CADx are still unclear.
Climate Change, Kidney Health, and Environmentally Sustainable Kidney Care
Authors: Shaifali Sandal, Isabelle Ethier, Ugochi Onu, Winston Fung, Divya Bajpai, Workagegnehu Hailu Bilchut, Peace Bagasha, Letizia De Chiara, Ehab Hafiz, Brendan Smyth, Dearbhla Kelly, Maria Pippias, Vivekanand Jha
Journal: Journal of the American Society of Nephrology (2024)

Key Points A multinational survey of health care professionals on the kidney health impacts of climate change and the environmental burden of kidney care was conducted. Most participants reported knowledge gaps and high level of concern on these interconnected issues. Only a minority report personal or organizational initiatives in environmentally sustainable kidney care; this did not vary by country income level. Background Given the threat of climate change to kidney health and the significant environmental effect of kidney care, calls are increasing for health care professionals and organizations to champion climate advocacy and environmentally sustainable kidney care. Yet, little is known about their engagement, and existing literature is primarily emerging from high-income countries. Methods We conducted a cross-sectional survey to understand the knowledge, attitude, and practice of health care professionals on the interconnectedness of climate change and kidney health; to identify personal and organizational initiatives in sustainable kidney care and strategies to increase their engagement; and to compare responses by their country's income level as classified by the World Bank. Results Participants ( n =972) represented 108 countries, with 64% from lower- or middle-income countries. Ninety-eight percent believed that climate change is happening, yet &lt;50% possessed knowledge about the effect of climate change on kidney health or the environmental effect of kidney care. Only 14% were involved in climate change and kidney health initiatives (membership, knowledge/awareness, research, and advocacy), 22% in sustainable kidney care initiatives (education/advocacy, preventative nephrology, sustainable dialysis, promoting transplant/home therapies, and research), and 26% reported organizational initiatives in sustainable kidney care (sustainable general or dialysis practices, preventative/lean nephrology, and focused committees). Participants from lower-income countries generally reported higher knowledge and variable level of concern. Engagement in sustainable kidney care did not vary by income level. Guidance/toolkit (79%), continuing education (75%), and opportunities (74%) were the top choices to increase engagement. National initiatives (47%), preventative measures (35%), and research endeavors (31%) were the top avenues for organizational engagement. These varied by income level, suggesting that the vision and priorities vary by baseline resource setting. Conclusions We have identified knowledge and practice gaps among health care professionals on the bidirectional relationship between kidney disease and climate change in a multinational context and several avenues to increase their engagement.
Incidental Detection of Second Primary Thyroid Malignancy in Patients of Metastatic Castration-Resistant Prostate Carcinoma
Authors: Aamir Nazar, Ashwini Kalshetty, Sandip Basu
Journal: Clinical Nuclear Medicine (2024)

Second primary tumors are being increasingly detected owing to and in proportion to the use of advanced imaging modalities including PET/CT. Patients suffering from prostate cancer have been reported to have increased second primary cancers of gastrointestinal tract, urinary bladder, and thyroid. We herein describe incidental detection of thyroid carcinoma, in 2 patients of mCRPC (metastatic castration-resistant prostate carcinoma) undergoing preradioligand therapy workup, on 68 Ga-prostate-specific membrane antigen PET/CT initially, subsequently also observed on multitracer PET/CT ( 64 CuCl 2 and 18 F-FDG). Thus, the potential of PET/CT for early in vivo second primary detection in mCRPC setting is illustrated in the aforementioned 2 patients.
Detection of Circulating Transthyretin Amyloid Aggregates in Plasma: A Novel Biomarker for Transthyretin Amyloidosis
Authors: Rose Pedretti, Lanie Wang, Mazen Hanna, Merrill D. Benson, Justin L. Grodin, W.H. Wilson Tang, Ahmad Masri, Lorena Saelices
Journal: Circulation (2024)