tbuckley/cabot-search huggingface dataset:
Abstract 16718: The Impact of Discontinuation of Dual Antiplatelet Therapy and Stent Fracture or Peri-Stent Contrast Staining on Very Late Stent Thrombosis After Sirolimus-Eluting Stent Implantation
Authors: Yasushi Fuku, Kazushige Kadota, Daiji Hasegawa, Yoshikazu Shigemoto, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Naoki Oka, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Circulation (2011)

Objectives: We evaluated the impact of discontinuation of dual antiplatelet therapy (DAPT) and stent fracture (SF) or peri-stent contrast staining (PSS) on very late stent thrombosis (VLST) after sirolimus-eluting stent (SES) implantation. Methods: Consecutive patients who had received the first SES implantation and had been evaluated by follow-up angiography within 12 months were analyzed. Stent thrombosis was defined according to the Academic Research Consortium definition. The incidence of VLST beyond 1 year after SES implantation was compared between the 4 groups of patients either with or without a diagnosis of SF or PSS at follow-up angiographic study within 12 months and continuation or discontinuation of DAPT. Results: Of 2494 patients who received the first SES implantation between November 2002 and December 2007, 2048 patients met the criteria for inclusion. The median duration of follow-up after the SES implantation was 1680 days (interquartile range 1362-1963 days). SF was observed at follow-up angiography within 12 months in 243 patients (11.9%), PSS in 59 patients (2.9%) and either SF or PSS (SF/PSS) in 271 patients (13.2%). Figure shows that the 5-year cumulative incidence of definite ST in patients stopped DAPT was significantly higher than that in patients continuing DAPT in the SF/PSS (+) group (11.4% vs. 0 %, p&lt;0.001), whereas no differences were observed in patients stopped DAPT versus patients continuing DAPT in the SF/PSS (-) group (0.7% vs. 0.3%, p=0.29). The incidence of definite ST in patients stopped DAPT was also significantly higher than that in patients continuing DAPT in the SF (+) group and PSS (+) group, respectively (9.9% vs. 0%, p=0.001; 19.1% vs. 0%, p=0.041). Conclusions: DAPT should be continued when SF or PSS was observed at follow-up angiography after SES implantation. In contrast, it may be possible that DAPT will be discontinued when SF or PSS was not observed.
Paediatric endoscopy should be carried out under general anaesthesia
Authors: M. D Stringer, P. J M McHugh
Journal: BMJ (1995)

Niuhuang Wan was found to contain 47 mg mercury and Zhusha Aushen 659 mg mercury (in the form of cinnabar).Arsenic and lead were also detected.When taken together as prescribed this would have resulted in a daily intake of 706 mg of cinnabar.We are concerned that the use of this amount of mercuric sulphide in long term treatment is potentially hazardous and could lead to mercury intoxication.Kew et al reported symptoms of mercury poisoning in a patient after daily exposure to 180-252 mg cinnabar for four weeks.2Cinnabar has been used for a long time in traditional medicines.The toxic effects of inorganic mercury are well recognised, but because of its insolubility it has been assumed that this compound would not be significantly absorbed from the gastrointestinal tract.However, a study by Yeon et al of the oral absorption of cinnabar in mice found a significant increase in mercury concentrations in the liver and kidney.Con- comitant use of cinnabar and drugs containing bromides, sulphates, sulphides, nitrates, and iodine may enhance its toxicity by increasing the gastrointestinal absorption.'We wish to bring the availability and use of these preparations to the attention of medical professionals and to emphasise the importance of obtaining full information on all the medications used by their patients.We are carrying out a traditional remedies surveillance project and would be interested in receiving reports of adverse reactions to herbal remedies and food supplements.
The obesity epidemic in young children
Authors: W. H Dietz
Journal: BMJ (2001)

Despite its successful use in academic research, next-generation sequencing (NGS) still represents many challenges for routine clinical adoption due to its inherent complexity and specialised expertise typically required to set-up, test and operate a complete workflow.This study aims to evaluate QIAGEN9s newly launched GeneReader NGS System solution in a pathology laboratory setting by assessing the system9s ease of use, sequencing accuracy and data reproducibility. Our laboratory was able to implement the system and validate its performance using clinical samples in direct comparison to an approved Sanger sequencing platform and to an alternative in-house NGS technology. The QIAGEN workflow focuses on clinically actionable hotspots maximising testing efficiency. Combined with automated upstream sample processing and integrated downstream bioinformatics, it offers a realistic solution for pathology laboratories with limited prior experience in NGS technology.
Dermatologic Allergy: Immunology, Diagnosis, Management.
Authors: Leo Hermann Criep
Journal: Annals of Internal Medicine (1967)

therapy of resistant falciparum malaria are included.Dis- cussion of such medical problems as cholera, dengue fever, and schistosomiasis is of renewed interest while recently recognized diseases as Kuru and Acanthoamoeba infections are brought to the attention of the reader.Laboratory techniques are adequately described.The utility of the book as a standard reference for tropical diseases both for the medical student and the practitioner is enhanced by the appendix attempting to enumerate diseases present in geographical areas of the world.Although the list is far from complete, presumably due to inadequacies of disease-reporting methods, it serves as a guide to the recognition of an illness which may have been contracted abroad and manifested only upon return to the United States.
Abstract 16040: Angiogenesis Driven Myocardial Hypertrophy Through a Nitric Oxide-RGS4 Dependent Mechanism
Authors: Irina M Jaba, Zhen W Zhuang, Daniela Tirziu
Journal: Circulation (2011)

Previously, we reported that an increase of vascular bed in the normal adult heart leads to myocardial hypertrophy in the absence of external stimuli. However the mechanism of angiogenesis-driven m...
Quality of care for people with dementia
Authors: J. Scott, C. Edwards, C. Fox, C. Bowman, G. Stokes
Journal: BMJ (2001)

Editor—Are readers surprised by Ballard et al's findings that nursing homes are failing the needs of patients with dementia?1 Probably not, especially if they spend any time in nursing homes either as a healthcare professional or as a relative or friend.

Ballard et al's conclusion that strategies to improve joint working between the agencies to provide integrated specialist services sounds good, but surely it's the day to day care that's failing people with dementia. Of course they need specialised services, but they need compassion, an understanding of their needs, appropriate activities, and human interaction. These things need time and a special kind of staff who enjoy working with elderly people with challenging problems.

Until relatively recently we were also failing children with severe learning disabilities. Now we understand these children's needs and rights to education, choice, and social interaction. People who work with these children are highly regarded in our society, if not well financially remunerated. It seems to me that until we start to apply the same ethos of care to our elderly people that we apply to our ill and disabled children we will continue to fail them. We must always remember that one day it may be us sitting in that chair with no way of communicating our distress.
Abstract 3176: Percutaneous Pulmonary Valve Implantation Is A Successful Treatment Option For RVOT Conduit Failure After Ross Procedure
Authors: Johannes Nordmeyer, Philipp Lurz, Louise Coats, Fiona Walker, Andrew M Taylor, Sachin Khambadkone, Philipp Bonhoeffer
Journal: Circulation (2007)

Background- The Ross operation offers good autograft function and low re-operation rates for the left ventricular outflow tract, however, the rate of conduit dysfunction in the right ventricular outflow tract (RVOT) remains a significant concern. Percutaneous pulmonary valve implantation (PPVI) is a novel trans-catheter treatment option for RVOT conduit dysfunction. Methods and Results- Of the 156 patients who underwent PPVI at our institutions with the current device, we retrospectively analyzed the outcomes of 11 patients (mean age: 26±5 years) who had RVOT conduit failure, 11.3±3.2 years following the Ross operation. PPVI could be performed in all patients (procedure time: 100±15 min; fluoroscopy time: 20±6 min). The RVOT gradient during catheterization and pulmonary regurgitant fraction (PRF) measured on magnetic resonance imaging (MRI) fell after PPVI (RVOT gradient: 35±6.5 mmHg to 14±2.8 mmHg, P&lt;0.01; PRF: 18±6% to 3±2%, P&lt;0.05). During mean follow-up of 17.4±5.2 months, there was 1 explantation (re-stenosis). The probability for freedom from RVOT re-operation was 100% at 1 year and 85.7% at 3 years. Conclusions- Failure of the conduit in the RVOT following Ross procedure can be successfully treated with PPVI to decrease the cumulative surgical burden in the lifetime management of congenital or acquired lesions of ventricular outflow tracts.
Abstract 14772: A Novel Role For Sphingosine Kinase-2 In PTP-mediated Cell Survival During Cardioprotection
Authors: Ludovic Gomez, Melanie Paillard, Megan Price, Qun Chen, Geoffrey Teixeira, Sarah Spiegel, Edward Lesnefsky
Journal: Circulation (2011)

Rationale: Although mitochondria are key determinants of myocardial injury during ischemia-reperfusion (I/R), their interaction with critical cytoprotective signaling systems is not fully understoo...
Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency
Authors: Stephen J. Peroutka, Solomon H. Snyder
Journal: American Journal of Psychiatry (1980)

The authors examined the potencies of 22 neuroleptic drugs competing for binding sites associated with dopamine, serotonin, alpha-adrenergic, and histamine receptors in brain membranes. They found that although many neuroleptics are quite potent in competing at several of these receptor sites, the average antipsychotic clinical potency correlates closely only with the drug affinity for dopamine receptors labeled by 3H-spiroperidol At clinically effective doses, however, substantial occupancy of serotonin, alpha-adrenergic, and histamine receptors often occurs and may account for some of the auxiliary actions of neuroleptics.
Abstract 12703: Association of Serum Paraoxonase-1 With Platelet Responsiveness to Clopidogrel in Patients With Acute Coronary Syndromes
Authors: Alexandros D Tselepis, Maria E Tsoumani, Kallirroi I Kalantzi, Andromachi A Dimitriou, Ioannis V Ntalas, Constantinos C Tellis, Ioannis A Goudevenos
Journal: Circulation (2011)

Introduction:  Paraoxonase-1 (PON-1), a high density lipoprotein (HDL)-associated enzyme, is involved in the formation of clopidogrel9s active thiol metabolite.   Hypothesis:  PON-1 may significantly influence the antiplatelet efficacy of clopidogrel in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI).   Methods:  We studied 74 patients, aged 63.3±8.6 years, (52 men) with recent (   Results:  All baseline platelet activation parameters were progressively attenuated at 5-days and 30-days of follow-up, whereas baseline HDL-C levels (45.5±15.1 mg/dL), paraoxonase (81±38 U/L) and arylesterase (51±15 U/mL) activity were not altered during follow-up. HDL-C levels were inversely associated with all platelet activation parameters at baseline, 5-days and 30-days as well. At 5-days of follow-up, 17 patients were clopidogrel nonresponders (PRI: 64.2±11.1%), whereas at 30-days, these values were reduced to 41.2±16.1% (P   Conclusions:  PON-1 influences clopidogrel antiplatelet efficacy in ACS patients, a phenomenon that is highly dependent on clopidogrel response variability and may be clinically important in clopidorel-treated patients, especially the first days after the episode.
Abstract 9232: Admission Heart Rate and In-Hospital Outcomes in Patients Hospitalized for Heart Failure
Authors: Anh L Bui, Maria V Grau-Sepulveda, Adrian F Hernandez, Eric D Peterson, Clyde W Yancy, Deepak L Bhatt, Gregg C Fonarow
Journal: Circulation (2012)

Background: Prior studies have suggested an association between higher heart rate (HR) and higher mortality, particularly in chronic heart failure (HF). Whether this relationship holds true in patients hospitalized with HF and differs between those in sinus rhythm (SR) and those in atrial fibrillation (AF) and by ejection fraction (EF) and has not been well studied. Methods: We examined 145,211 admissions for HF from 295 hospitals enrolled in Get With The Guidelines-Heart Failure from January 2005 through September 2011. Results: The median admission HR was 82 (IQR 70-97). Patients presenting at higher HR tended to be younger, have less comorbidities, and lower ejection fraction. In-hospital mortality had a J-shaped relationship with HR, with the lowest mortality rate with HR 70-75 (Figure). However, the relationship of mortality and HR differed between patients presenting in SR and AF: at HR above 100 bpm, the mortality curve for AF plateaued, whereas that for patients in SR continued to rise. The J-shaped curves remained similar for patients in HF with reduced EF and those with preserved EF, although patients in HF with preserved EF had a higher risk of mortality with increasing HR above 105 compared to those with reduced EF, but a lower risk of mortality below that cutpoint. After adjusting for patient and hospital characteristics, higher HR was associated with higher mortality (adjusted odds ratio [aOR] 1.26, 95% CI 1.22-1.31 per 10 bpm increase in HR) and longer length of stay (aOR 1.10, 95% CI 1.09-1.12 for LOS &gt; 4days). Conclusions: Higher admission HR is independently associated with worse outcomes in patients admitted for HF, in those in SR and AF and preserved and reduced EF. Whether early reduction in HR will improve short-term outcomes in patients hospitalized with HF is worthy of investigation. -.
Spectrum Of Genetic Alterations In Acquired Aplastic Anemia
Authors: Tetsuichi Yoshizato, Bogdan Dumitriu, Kohei Hosokawa, Hideki Makishima, Kenichi Yoshida, Yusuke Okuno, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Yasunobu Nagata, Takamasa Katagiri, Ayana Kon, Michael J. Clemente, Masashi Sanada, Satoru Miyano, Jaroslaw P. Maciejewski, Shinji Nakao, Neal S. Young, Seishi Ogawa
Journal: Blood (2013)
Abstract 2857: Incidence of Complete Circumferential Scar of the Pulmonary Vein Antra Following Ablation of Atrial Fibrillation: Assessment of Contiguous Lesions With Delayed Enhancement MRI
Authors: Troy J Badger, Nathan S Burgon, Yaw A Adjei-Poku, Nazem Akoum, Thomas S Haslam, Nicholas W Brown, Saul Kalvaitis, Eugene G Kholmovski, Rob S MacLeod, Christopher J McGann, Nassir F Marrouche
Journal: Circulation (2009)

Background: Circumferential pulmonary vein ablation is the preferred atrial fibrillation (AF) ablation technique for many centers. However, the frequency of obtaining circumferential lesions using ...
Abstract 13212: Extensive Reserve Capacity for the Binding and Movement of Fibrinogen on the Surface of Activated Human Platelets
Authors: Linda G Westrick, Evan S Krystofiak, Julie A Oliver
Journal: Circulation (2010)

We have previously imaged fibrinogen binding to its integrin αIIb β3 receptor on activated human platelets through labeling with colloidal gold-ligand conjugates followed by light and/or electron m...
Suicidal behavior by preschool children
Authors: Perihan A. Rosenthal, Stuart Rosenthal
Journal: American Journal of Psychiatry (1984)

Sixteen suicidal preschoolers age 21/2 to 5 years who were referred to a university child psychiatry outpatient clinic were compared with 16 behaviorally disordered preschoolers matched by age, sex, race, and parental marital and socioeconomic status. The suicidal group showed significantly more nonsuicidal self-directed aggression, loss of interest, morbid ideas, depression (according to the Weinberg criteria, but not DSM-III), impulsivity and hyperactivity, and running away behavior. They also showed significantly less pain and crying after injury; more of the children were unwanted and abused or neglected by parents. Four subgroups of suicidal motivation are identified and discussed.
Abstract 148: Superoxide Promotes Reversible Uncoupling Of Inducible Nitric Oxide Synthase, While Peroxynitrite Induces Irreversible And Complete Enzyme Inactivation
Authors: Jian Sun, Lawrence J Druhan, Jay L Zweier
Journal: Circulation (2007)

Inducible nitric oxide synthase (iNOS) is present in the post-ischemic heart, and plays an important role in the pathogenesis of injury and remodeling. Oxidants formed during reperfusion injury are known to alter NOS function. In this study we compare and contrast how two biologically relevant oxidants, peroxynitrite (ONOO − ) and superoxide (O 2 − ), alter iNOS function and define the mechanisms involved for each. Nitric oxide (NO) generation rate of purified iNOS was quantified by the methemoglobin formation, O 2 −. generation was measured using EPR spin-trapping, and the quaternary structure of iNOS by size-exclusion FPLC. Tetrahydrobiopterin (BH 4 )-replete iNOS (1 μM) was exposed to O 2 −. , and ONOO − in concentrations from 0.01 μM to 500μM and NO production was measured with and without addition of excess BH 4 . ONOO − (50μM) decreased NO production to 19% ± 0.17 and excess BH 4 only partially restored activity to 48% ± 3.4. O 2 −. (50 μM) reduced NO production to 42% ± 1.2 and the excess BH 4 completely restored activity to 100% ± 3.1. ONOO − exerted the highest decrease in NO production rate (96% ± 1.3 activity loss at 500 μM ONOO − ) and no activity was restored by excess BH 4 . In contrast, O 2 −. induced a significant decrease (90% ± 1.2 activity loss at 500 μM O 2 −. ), however excess BH 4 restored the iNOS activity back to 69% ± 5.6.O 2 −. exposure enhanced O 2 −. production from iNOS (up to 155% ± 0.72 at 50 μM O 2 −. ), while ONOO − at higher concentrations (&gt;20μM) reduced O 2 −. production (10% ± 3.2 decrease at 50 μM ONOO − ). We also found that incubation with ONOO − and O 2 −. induced iNOS monomerization. In conclusion, both ONOO − and O 2 −. decrease iNOS NO production in a dose dependent manner. Adding excess BH 4 only partially restore the loss of NO production induced by ONOO − , but almost completely restore the loss of NO production induced by O 2 −.. Therefore, O 2 −. promotes the uncoupling of iNOS and elevates O 2 −. production by oxidizing the protein bound BH 4 with subsequent formation of NOS monomer in a reversible fashion. Conversely, ONOO − induces irreversible enzyme inactivation and decreases both NO and O 2 −. production. Although oxidation of BH 4 is involved in the observed ONOO − induced loss of iNOS activity, there are other causes, including oxidation of critical amino acid residues.
Abstract 2290: Evolution Of Moderate Chronic Ischemic Mitral Regurgitation In Patients Underwent Only Coronary Artery Surgery: Clinical And Echocardiographic Follow-up At Rest And Under Exrecise
Authors: Khalil Fattouch, Roberta Sampognaro, Gaetano panzarella, Francesco Guccione, Giovanni Ruvolo
Journal: Circulation (2008)

Objective:  Management of moderate chronic ischemic mitral valve regurgitation (cIMR) is still debated. Several authors favouring surgical treatment in combining with coronary artery bypass grafting (CABG) while others suggested conservative approach. However, evolution of moderate cIMR after only CABG is still unclear. Aim of this study was to evaluate prospectively, at rest and under exercise condition, the clinical outcomes and echocardiographic results of patients with moderate cIMR underwent only CABG.   Methods:  Since February 2003, 176 patients with moderate cIMR survived CABG surgery were prospectively followed. Follow-up was obtained at 1 month and 1, 3, 5 years and was 100% complete. Mean follow-up was 30±16 months. At last follow-up, exercise test was performed in all survivors to evaluate tolerance to exercise and variability of mitral regurgitation (MR) grade and of systolic pulmonary arterial pressure (sPAP).   Results:  Five-years survival rate was 73.8±3.2%. Late death occurred in 46 patients. Predictors for late death were NYHA Class ≥ III, LVEDD ≥ 60 mm, LVEF% ≤40, and PAPs ≥ 50 mmHg. At follow-up, CABG was able to reduce MR grade in 30% of patients whereas in the 35% of patients MR grade remained stable and in the 35% worsened. Predictors for MR grade worsening were LVEDD>60 mm (p 1.8 cm2 (p   Conclusions:  In patients with moderate cIMR, only CABG could not be effective in term of survival, clinical outcome, and decreasing of MR. Failure of CABG in MR treatment is well demonstrated by the worsening in MR grade in the 35% of patients. Moreover, residual postoperative MR can lead to no reversal remodeling. After CABG alone the grade of MR worsened under exercise leaved more patients with heart failure symptoms despite the MR grade at rest condition.
Diagnosis
Authors: Graeme P Currie, Joe S Legge
Journal: BMJ (2006)

As with most other common medical conditions, the diagnosis of chronic obstructive pulmonary disease (COPD) depends on a consistent history and appropriate examination findings.Confirmatory objective evidence is provided by spirometry.Doctors should consider the possibility of COPD in any patient aged 35 years or older with any relevant respiratory symptom and a history of smoking.
Histological Effects of Long-Continued Whole-Body Gamma-Irradiation of Mice&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: B. Spargo, J.R. Bloomfield, D.J. Glotzer, E.L. Gordon, O. Nichols
Journal: JNCI Journal of the National Cancer Institute (1951)

Histological Effects of Long-Continued Whole-Body Gamma-Irradiation of Mice Get access B. Spargo, B. Spargo Department of Anatomy and Institute of Radiobiology and Biophysics, University of Chicago, The Argonne National Laboratory, Chicago, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. R. Bloomfield, J. R. Bloomfield Department of Anatomy and Institute of Radiobiology and Biophysics, University of Chicago, The Argonne National Laboratory, Chicago, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar D. J. Glotzer, D. J. Glotzer Department of Anatomy and Institute of Radiobiology and Biophysics, University of Chicago, The Argonne National Laboratory, Chicago, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Leiter Gordon, E. Leiter Gordon Department of Anatomy and Institute of Radiobiology and Biophysics, University of Chicago, The Argonne National Laboratory, Chicago, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar O. Nichols O. Nichols Department of Anatomy and Institute of Radiobiology and Biophysics, University of Chicago, The Argonne National Laboratory, Chicago, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 3, December 1951, Pages 615–655, https://doi.org/10.1093/jnci/12.3.615 Published: 01 December 1951 Article history Received: 20 July 1951 Published: 01 December 1951