tbuckley/cabot-search huggingface dataset:
Nerve Wounds: Symptomatology of Peripheral Nerve Lesions Caused by War Wounds.
Authors: Cecil Augustus Joll, Fred Rothwell, Jules Tinel
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Topics in Gastroenterology 2.
Authors: S. C. Truelove, D. P. Jewell, Martin F. Heyworth
Journal: Annals of Internal Medicine (1975)

The oesophagus : Assessment of oesophageal function A. Ogilvie Atypical chest pain C. E. Pope Management of oesophagitis T. C. B. Dehn Duodenal ulcer : Mechanisms of acid secretion M. Parsons Pathophysiology of duodenal ulcer W. D. W. Rees & A. B. Dowd Prostaglandin therapy R. P. Walt Omeprazole-mechanisms of action and pharmacology E. Carlsson, P. Lindberg, H. Mattson & B. Wallmark Omeprazole-clinical aspects A. Walan . Intestinal immunology and infection : Cellular aspects of gastrointestinal immunity G. McPherson Allergic disorders of the intestine P. J. Milla Immunodeficiency I. Ross Lymphomas of the small intestine H. J. F. Hodgson Viruses and diarrhoea C. R. Madeley E Coli- pathogenic mechanisms D. Candy, S. Knutton & A. S. McNeish Is Entamoeba histolytica a pathogen or a commensal? P. G. Sargeaunt Immunity and schistosomiasis P. Hagan . Ano-rectal disease : Pathophysiology of the ano-rectum N. W. Read & W. H. Sum Obstructive defaecatory disorders D. C. Bartolo Management of incontinence N. Mortenson Piles and pruritus M. G. W. Kettlewell .
Rituximab Maintenance after Chemoimmunotherapy Induction in 1st and 2nd Line Improves Progression Free Survival: Planned Interim Analysis of the International Randomized AGMT-CLL8/a Mabtenance Trial
Authors: Richard Greil, Petra Obrtlikova, Lukas Smolej, Tomas Kozak, Michael Steurer, Johannes Andel, Josef Thaler, Eva Mikuskova, Liana Gercheva, Thomas Nösslinger, Miriam Ladicka, Michael Girschikofsky, Mikulá Hrubiko, Ulrich Jäger, Michael A. Fridrik, Martin Pecherstorfer, Eva Kralikova, Cristina Burcoveanu, Stefcho Goranov, Jana Jurkovikova, Andreas L. Petzer, Georgi G. Mihaylov, Julian Raynov, Horst Oexle, August Zabernigg, Emilia Flochova, Stanislav Palasthy, Thomas Melchardt, Jiri Mayer, Alexander Egle
Journal: Blood (2014)
meta-analysis bias in location and selection of studies
Authors: M. Egger, G. D. Smith
Journal: BMJ (1998)

Meta-analysis has received a mixed reception since the outset. Some people have rejected what they see as exercises in “mega-silliness,”1 while the purveyors of a highly distinguished series of meta-analyses of perinatal medical care2 have been dismissed as “an obstetrical Baader-Meinhof gang.”3 To some clinicians objecting to the findings of meta-analyses, “a tool has become a weapon.”4 At the other end of the spectrum, the application of a technique that basically consists of calculating a weighted average has been hailed as “Newtonian,”5 and it has been suggested that meta-analysis has left no place for the narrative review article.6 The truth is likely to lie somewhere between these extreme views.

#### Summary points

That meta-analysis holds potential problems can be illustrated by contrasting the conclusions of two meta-analyses comparing low molecular weight heparins and standard heparin in the prevention of thrombosis after surgery.7 8 One group concluded that “low molecular weight …
Streptokinase is more economical than alteplase
Authors: J C Mucklow
Journal: BMJ (1995)

technique, and outcome of peripheral thrombolysis for the past two years.2This is a continual process to provide a system for the national audit of peripheral arterial thrombolysis, and so far over 450 events of thrombolysis have been recorded.In these, only 13% of infusions were given with a pulse spray technique, in a median time of six hours (range 1-78 hours).Pulse spray lysis is certainly faster than conventional low dose techniques, but it requires expensive catheters and infusion systems.Other methods, such as high dose bolus thrombolysis and six hourly dose infusions, have also been reported to reduce infusion times without expensive equipment.34Personal communications with the manu- facturers of pulse spray infusion catheters also suggest that relatively few hospitals in Britain use the pulse spray technique.Little information is available on many of the techniques for peripheral thrombolysis, and low dose infusions remain the gold standard for many hospitals in Britain.
Supportive Care of the Cancer Patient.
Authors: J. W. Sweetenham, C. Williams
Journal: Annals of Internal Medicine (1983)

Bone marrow suppression - introduction, R. Clarke bone marrow transplantation and management of complications - infection, new antibiotics, isolation policies, antifungals, antivirals, P. Pizzo and A. Freifeld haemopoietic growth factors, R. Mertelsmann supportive of non-marrow complications, P. Schein chronobiology of drug delivery and avoidance of toxicity, W. Hurchesky nutrition, dietary and hormonal, Dr Tchekmedyian supportive therapy and biological agents - the use of cytokines in supportive therapy, anti-endotoxin and anti-cytokine therapy in the management of septic shock, support of complications of cytokine therapy, R. Herberman support of treatment-related complications, nausea and vomiting,, D. Gandara management of HIV/HBsAg in the cancer patient, psychological support, support groups, counselling, staff support, A. Hall quality of life assessment, specific supportive problems, supportive therapy of elderly cancer patients, U. Tirelli supportive therapy of children with cancer, T. Oakhill the role of interventional radiology, S. Birch metabolic complications of cancer, R.E. Coleman hypercalciuma, D. Hinger advances in pain control - morphine, metabolites etc., C. Davis treatment of cancer-associated disturbances of blood coagulation, S. Roath.
Doctors' right to refuse to perform abortions
Authors: D. Cox
Journal: BMJ (1994)

studies of smoking cessation smokers' activities in attempting to stop smoking should be measured in tandem with more conventional measures of the rate of cessation.4Attempts to stop are associated with the final goal of continuous abstinence.Changes in the number of attempts to stop may thus be more sensitive to intervention than the dichotomous outcome of smoking cessation.This is just one suggestion, and much work is required to validate any new outcome measures.'The results of Cupples and McKnight's study2 suggest, however, that careful consideration of appropriate outcomes is vital to improving our knowledge about how we should approach health promotion.
Lipoprotein(a) Levels in Familial Hypercholesterolemia
Authors: Rodrigo Alonso, Eduardo Andres, Nelva Mata, Francisco Fuentes-Jiménez, Lina Badimón, José López-Miranda, Teresa Padró, Ovidio Muñiz, Jose Luis Díaz-Díaz, Marta Mauri, Jose María Ordovás, Pedro Mata
Journal: Journal of the American College of Cardiology (2014)
Proposals may damage one of finest examples of postgraduate medical education
Authors: W. Coppola
Journal: BMJ (1995)

initial marking, it is impossible to sit beside one's coexaminer for 30 minutes without forming a (usually accurate) impression of what the co- examiner's mark is likely to be.All of these factors would tend to increase the interexaminer agreement but not necessarily increase the reliability of the vivas.A more thorough analysis would enable us to judge whether the commonly held view that vivas are inherently unreliable can now be revised.
General Theory of Neuroses: Twenty-Two Lectures on the Biology, Psychoanalysis and Psychohygiene of Psychosomatic Disorders
Authors: Rudolf Brun
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vascular endothelial function is related to endothelial biomarkers in early RA
Authors: A. Sodergren, K. Boman, C. Eriksson, K. Karp, E. Lundstrom, Solbritt Rantapää-Dahlqvist, T. Smedby, L. Soderlund, S. Wallberg-Jonsson
Journal: Annals of the Rheumatic Diseases (2007)
High prevalence of visual hallucinations in research subjects with chronic schizophrenia
Authors: H S Bracha, O M Wolkowitz, J B Lohr, C N Karson, L B Bigelow
Journal: American Journal of Psychiatry (1989)

The authors examined the prevalence of visual hallucinations in severely ill hospitalized research subjects with carefully diagnosed chronic schizophrenia and found it to be high. A chart review of 100 discharged subjects revealed documentation of visual hallucinations in 32%, and a prospective examination of 43 additional subjects revealed a history of visual hallucinations in 56% (N = 24). Also, the fact that in 43% of the patients with visual hallucinations the history of visual hallucinations was first documented during the research ward work-up suggests that clinicians frequently do not inquire about visual hallucinations in patients with chronic schizophrenia.
Intravenous Procaine
Authors: C. A. Keele
Journal: BMJ (1947)

mented in a very valuable article on the benefits he has observed in skin and other diseases from the use of vitamin K analogue, and recently in " Any Questions " in the Journal (Jan.11, p. 77) your expert stated that vitamin K seemed " to exercise a bene- ficial effect in some cases of perniosis-and this was borne out in the case I am recording where the patient said his cold feet were warmer after taking the drug.May I therefore sug- gest that vitamin K analogue shiould be given a trial in Behcet's syndrome and the result of such treatment recorded.-Iam, etc., Paignton.
Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells.
Authors: J W Young, R M Steinman
Journal: The Journal of Experimental Medicine (1990)

Cytotoxic lymphocytes are typically generated from unfractionated suspensions of human lymphocytes by stimulating with heterogeneous APCs and exogeneous growth factors. We have found that human blood dendritic cells can directly stimulate allogeneic human CD8+ T cells to proliferate and express antigen-specific cytotoxic activity. These primary responses, which are accompanied by the release of T cell growth factor(s), are induced in the absence of CD4+ helper T cells and are not inhibited by anti-CD4 mAb. Both antigen-specific CTL as well as nonspecific NK cells can be elicited by dendritic cells. The NK cell response can be depleted at the precursor level by panning with an anti-CD11b mAb, which removes a CD11b+/CD28-, CD16+ subset from the starting CD4- responders. Allogeneic blood monocytes are neither stimulatory nor inhibitory of these primary CD4- MLRs, even though monocytes present alloantigen in such a way as to be recognized as specific targets for CTL that have been sensitized by dendritic cells. The number of CD8+ cells that are blast transformed and express an activated phenotype (i.e., HLA DR/DQ+, CD25/IL-2R+, CD45R-) reaches 30-40% of the culture at day 4-5, the peak of the helper-independent response. We conclude that antigen-presentation by dendritic cells is sufficient in itself to prime cytolytic precursors. We speculate that using dendritic cell stimulators and CD4- responders in MLRs may be more efficient than standard tissue typing approaches for the detection of subtle, but important class I MHC-restricted histoincompatibilities in human transplantation.
Prophylactic use of K1 cream for reducing skin toxicity during cetuximab treatment in patients with metastatic colorectal cancer (mCRC).
Authors: J. Ocvirk, M. Rebersek, M. Boc, T. Mesti, M. Ebert
Journal: Journal of Clinical Oncology (2010)

e14011 Background: Cetuximab (C) is registered as the first-line treatment of mCRC pts with KRAS wild type. Approximately 80% of pts have skin toxicity, the most common are acne-like rash, which can be the reason for reducing the dose of C or delaying treatment. Preclinical studies have shown that vitamin K1 reactivated EGFR-mediated signal transduction after the inhibition via EGFR receptor antagonists. Methods: From September 2008 to December 2009, 48 (29 m/19 f) mCRC pts were treated with weekly C in combination with first-line Cht, most of them with XELOX (XELOX/XELIRI/FOLFOX/FOLFIRI- 47.9/37.5/8.3/6.3%). Prophylactic use of cream with K1 vitamin (Reconval K1) was prescribed on the day of starting C-treatment. The cream was applied twice daily (td) on the face and chest. Pts were followed once a week, 8 weeks in a row. Skin toxicity was evaluated according to NCI CTCAE, ver.3. Results: Of 48 pts, 43 were given K1 creme prophylactically, td on a regular basis. The acne-like rash started developing in the first week of treatment, but it was observed only in 31% of pts, mainly as G1 (25%). The peak of rash was observed in the third week, in 31 pts (64.6%), as G1 and G2 in 24 pts (50%) and in 7 pts (14.6%), respectively. No G3/G4 skin toxicities were observed. Compared to the results of previous studies, we observed all grades in 64.4% vs 85% (G1 50% vs. 15%-26%, G2 14.6% vs. 45%-60%, G3/G4 0% vs. 13%-17%). Topical antibiotic was prescribed in 9 pts (18.8%), also in the third week, systemic antibiotic only in one pt (2.1%) in the fourth and seventh week. We didn't observe any toxicity of K1 cream. Conclusions: Prophylactic use of K1 vitamin cream is very effective in reducing the intensity and frequency of C-induced cutaneous toxicity in mCRC pts. We observed that the rash developed with delay and that the need for topical and systemic antibiotic treatment was reduced. No higher than G1/G2 skin toxicity was observed. There was no need to reduce the dose of C or delay treatment. No significant financial relationships to disclose.
Acute Lung Injury. Pathogenesis of adult respiratory distress syndrome
Authors: Homayoun Kazemi, Albert L. Hyman, Philip J. Kadowitz
Journal: Thorax (1987)

that changes in osmolality during nebulisation could have led to bronchoconstriction is not borne out by the failure of nebulised saline control to cause any reduction in VmaxFRC.It is possible that the low pH of salbutamol solution could have induced bronchoconstriction.The pH of our normal saline ampoles is 6-0 and of salbutamol nebules is 4-0 (not 7 6 and 6 25, as found by Dr O'Callaghan).However, neither histamine solution in low concentrations (below that which induced bronchoconstriction-pH around 5) nor ipratropium bromide nebuliser solution (pH 4 0) have caused a significant decline in VmaxFRC in our studies.1 2 The hy- pothesis that the pH of the nebuliser solution is a critical factor therefore remains speculative.More research in in- fants is clearly required.In answer to the comments of Dr Beasley and colleagues, the salbutamol respirator solution used in the study per- formed by O'Callaghan et al and the salbutamol "nebules" in our study contain benzalkonium chloride.Thus the reduction in VmaxFRC seen 15 minutes after salbutamol nebu- lisation could be preservative induced. 703We have performed a further study2 of change in airway function in 17 wheezy infants after nebulised ipratropium bromide, which also contains benzalkonium chloride.At 15-20 minutes after nebulisation of I ml of ipratropium bro- mide in 1 5 ml 0 9% sodium chloride there was a significant reduction in specific airway resistance with no significant change in VmaxFRC.Thus benzalkonium chloride, at least when present in nebulised ipratropium bromide, does not appear to induce bronchoconstriction in these infants.
Electro-Diagnosis and Electro-Therapeutics. A Guide for Practitioners and Students.
Authors: Toby Cohn, Francis A. Scratchley
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Demographic Revolution
Authors: Jane McLoughlin
Journal: BMJ (1952)

The  time  is the greatest social shift since the Industrial Revolution. The shortfall of nearly a million young people available for work will cause a radical rethinking of all aspects of our lives from work and education to family, social and financial matters. The book poses such crucial questions as: can the family survive?, what will education mean in the 21st century?, can men avoid becoming the redundant male? and will euthanasia be legalized? Jane McLoughlin reveals why the birthrate changed, how we were left unprepared, and the effects on us personally and at work. Finally she argues that far from being a potential disaster, the demographic time bomb could be a superb opportunity to alter our working lives for the better.
Prognostic factors identified in the long term survivors with limited small cell lung cancer
Authors: R. Komaki, P. K. Allen, X. Wei, Z. Liao, J. Y. Chang, H. Thames, B. S. Glisson, F. V. Fossella, Y. Oh, K. Ohnishi, J. D. Cox
Journal: Journal of Clinical Oncology (2008)

7552 Background: The purpose is to identify prognostic factors (PF) of patients (pts) who lived 3 years or longer after their treatment for the limited stage small cell lung cancer (LSCLC). Methods: Between March 1985 and December 2004, a total of 427 pts with LSCLC were treated at the UT MD Anderson C. C. Majority of pts received cisplatin/etoposide (PE), cyclophosphamide/vincristine/doxorubicin (CVA), ifosfamide/EP or CPT-11/cisplatin. Thoracic radiotherapy (TRT) dose ranged from 45 Gy/3 wks to 70 Gy/7 wks with the median dose 45 Gy/3 wks (biological equivalent dose (BED)=52). 309 pts lived less than 3 yrs and 118 pts lived 3 yrs or longer. Between 2 groups, we compared median age, gender, ethnic difference, weight loss (WL), Karnofsky Performance Status (KPS), maximum tumor size, location of the primary tumor, presence of non-malignant pleural effusion (Pl), surgery, total dose of TRT, BED, concurrent or sequential (SQ) chemotherapy (ChT) and TRT, # cycles of induction ChT, fractionation, loco-regional (LRC) or distant metastasis control (DMC), different decade of the treatment, prophylactic cranial irradiation (PCI), and smoking history including pack-yrs. Chi-square tests and univariate and multivariate Cox logistic regression were used for the analysis. Results: Univariate Cox logistic regression with OS as an endpoint has demonstrated that WL≤ 5%, KPS> 90, no Pl, +PCI, surgery, early BED≥52, conc. ChT/TRT compared to SQ, treated after 1995, LRC or DMC were significant PF. However, multivariate logistic regression with 3-y survival status as endpoint has demonstrated that no Pl, BED≥ 52, treatment after 1995, +PCI, LRC and DMC were only significant favorable PF. Median Survival was 25 mons (all cases), 27 mons (conc. ChT/TRT), 37 mons (induction ChT followed by ChT/TRT) and 18.8 mons (sequential treatment). Conclusions: One institutional retrospective analysis has shown that significant favorable PF for long -term survivors were no PlE, BED ≥52, more modern treatment, application of PCI, LRC and DMC. Based on fairly uniformly treated patients with regards to ChT and TRT factors, this information will be a mile stone for the LSCLC and these factors need to be tested on a prospective randomized trial. No significant financial relationships to disclose.
Abstract 21206: Aquaporin-Associated Vascular Development of Human Induced Pluripotent Stem Cells Stimulated with High Levels of Glucose
Authors: Rosalinda Madonna, Harnath Shelat, Yong J Geng
Journal: Circulation (2010)

Background and Objective: In overt diabetes, hyperglycemia increases the plasma osmolarity, leading to induction of hypertonicity-responsive genes, including those coding for the osmosensing water ...
Einführung in Geist und Studium der Medizin
Authors: Georg B.< Gruber, 鉦四郎 小立
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal