tbuckley/cabot-search huggingface dataset:
Breast Cancer Susceptibility Gene Sequence Variations and Development of Contralateral Breast Cancer
Authors: Anne S. Reiner, Gordon P. Watt, Kathleen E. Malone, Charles F. Lynch, Esther M. John, Julia A. Knight, Meghan Woods, Xiaolin Liang, Marc Tischkowitz, David V. Conti, Mark E. Robson, Lene Mellemkjær, Sharon N. Teraoka, Patrick Concannon, Jonine L. Bernstein
Journal: JAMA Network Open (2024)

Importance Heterogeneity in development of estrogen receptor (ER)-specific first primary breast cancer exists due to deleterious germline variants in moderate- to high-penetrance breast cancer susceptibility genes, but it is unknown if these associations occur in ER-specific CBC. Objective To determine the association of deleterious germline variants in breast cancer susceptibility genes with ER-specific CBC development and whether ER status of the first primary breast cancer modifies these associations. Design, Setting, and Participants This case-control study included CBC cases and matched unilateral breast cancer controls from The Women’s Environment, Cancer, and Radiation Epidemiology (WECARE) Study, a population-based case-control study. Eligible women were diagnosed between 1985 and 2000 with data and biospecimens collected from 2001 to 2004. Eligible participants were women younger than 55 years at first invasive breast cancer diagnosis. Participants were matched on age, diagnosis year, cancer registry region, and race and ethnicity, and countermatched on radiation treatment. For cases, CBC occurred 1 year or more following first breast cancer diagnosis. Analyses were performed from May to October 2024. Exposures CHEK2 1100delC and deleterious variants in ATM , BRCA1, and BRCA2 . Main Outcome and Measure Development of CBC, measured as a rate ratio (RR). Results A total of 1290 women were included in analysis (median [IQR] age at first diagnosis, 47 [42-51] years). The ER-positive CBC rate for women with deleterious ATM variants was 4 times higher than for women without deleterious ATM variants (RR, 4.84; 95% CI, 1.11-21.08; P = .04); no women with ER-negative CBC carried deleterious ATM variants. The ER-positive CBC rates for women with deleterious variants in BRCA2 or CHEK2 1100delC were 5 to 6 times higher than for women without deleterious variants in BRCA2 or CHEK2 1100delC, respectively ( BRCA2 : RR, 5.88; 95% CI, 2.61-13.26, P &amp;amp;lt; .001; CHEK2 1100delC: RR, 6.06; 95% CI, 1.26-29.04; P = .02). The ER-negative CBC rate for women with deleterious BRCA1 variants was 26 times higher than for women without deleterious BRCA1 variants (RR, 26.16; 95% CI, 8.01-85.44; P &amp;amp;lt; .001). First primary breast cancer ER status did not modify associations between deleterious variants and ER-specific CBC development. Conclusions and Relevance In this case-control study of CBC, deleterious variants in breast cancer susceptibility genes were differentially associated with ER-specific CBC development. Germline variation profile may inform estimates of outcomes for ER-specific CBC subtypes.
More on Neighborhood Food Access by Child Body Mass Index and Obesity
Authors: Ping-Hao Chiang, Chieh-Hsuan Tsai
Journal: JAMA Pediatrics (2024)

To the Editor Aris et al1 found that poorer household income and neighborhood food access were associated with a higher risk of obesity in children and adolescents. This highlights a crucial health care issue. Therefore, we believe this topic warrants further investigation.
More on Neighborhood Food Access by Child Body Mass Index and Obesity—Reply
Authors: Izzuddin M. Aris
Journal: JAMA Pediatrics (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2025 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Out-of-Pocket Savings Under the Inhaler Price Cap
Authors: Stephen A. Mein, Ave K. Kludze, William B. Feldman, Archana P. Tale, Jennifer P. Stevens, Rishi K. Wadhera
Journal: JAMA Internal Medicine (2024)

This cross-sectional study describes potential cost savings for both insured and uninsured users of brand-name inhalers in the US.
The Adolescent Brain Cognitive Development Study and How We Think About Addiction
Authors: Felix Pichardo, Sylia Wilson
Journal: JAMA Network Open (2024)

Alex P. Miller, PhD; David A. A. Baranger, PhD; Sarah E. Paul, MA; Hugh Garavan, PhD; Scott Mackey, PhD; Susan F. Tapert, PhD; Kimberly H. LeBlanc, PhD; Arpana Agrawal, PhD; Ryan Bogdan, PhD
Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease
Authors: Raphael Wurm, Sigrid Klotz, Astrid Erber, Felix Gruber, Stefan Leitner, Berthold Reichardt, Elisabeth Stögmann, Eva Schernhammer, Ellen Gelpi, Hakan Cetin
Journal: JAMA Neurology (2024)

Importance Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare, rapidly progressive and fatal neurodegenerative disease. Definite sCJD diagnosis can only be made post mortem, and little is known about the prodromal phase of the disease. Objective To compare drug prescription patterns before the clinical onset of sCJD between patients and matched controls for exploration of potential risk factors and to assess correlations between drug exposure and sCJD survival. Design, Setting, and Participants This retrospective analysis was designed as a case-control study, with data collected from January 2013 to December 2020 and analyzed in 2023. Follow-up was available until December 2020. Cases were collected from the Austrian Reference Centre for Human Prion Diseases, which receives all suspected cases at a national level in Austria. The analyses were conducted at a single center. Patients with autopsy-confirmed sCJD were linked with insurance claims data, and a minimum of 10 control individuals were matched by sex, age at onset, and area of residence for each patient with sCJD. Exposure Medication prescribed to 10% or more of the cohort with sCJD up to 5 years before symptom onset or the matching date in the control cohort. Main Outcomes and Measures Drug prescription before symptom onset or the matching date was compared between patients with sCJD and controls using conditional regression, and prescriptions in the cohort with sCJD were assessed for correlation with survival using Cox proportional hazard models. Results A total of 129 patients with sCJD (median [IQR] age, 68.9 [62.4-75.5] years; 67 female [51.9%]) and 1350 controls (median [IQR] age, 69.0 [62.2-75.3] years; 700 female [51.9%]) were included. As compared with controls, patients with sCJD were found to have significantly higher odds of being prescribed selective serotonin reuptake inhibitors (SSRIs) in the year preceding disease onset (odds ratio, 2.86; 95% CI, 1.63-4.95; P &amp;amp;lt; .001). SSRI prescription rates started to increase 3 years before symptom onset in the cohort with sCJD. Conclusions and Relevance Results of this case-control study provide evidence for prodromal mood alterations as early as 3 years before symptom onset in patients with sCJD. Although sCJD remains an extremely rare cause of mood alterations, increased vigilance for neurodegenerative diseases in this setting could eventually help to extend the diagnostic window.
Low Uptake of Lipid Screening—Concerning Nonadherence or Appropriate Skepticism?
Authors: Elizabeth R. Wolf, Thomas B. Newman, Rita F. Redberg
Journal: JAMA Pediatrics (2024)

This Viewpoint discusses factors that play a role in the low rate of lipid screening in children, including a lack of compelling evidence, disagreement with recommendations, and concerns for overdiagnosis and overtreatment.
Trends of Violence in Movies During the Past Half Century
Authors: Babak Fotouhi, Amir Tohidi, Rouzbeh Touserkani, Brad J. Bushman
Journal: JAMA Pediatrics (2024)

This cross-sectional study of English-language movies produced from 1970 to 2020 explores how violence reflected in dialogues has changed over time, whether the observed trends are limited to crime movies, and how the trends differ for male and female characters.
Occurrence and Time of Onset of Intraventricular Hemorrhage in Preterm Neonates
Authors: Zsuzsanna Nagy, Mahmoud Obeidat, Vanda Máté, Rita Nagy, Emese Szántó, Dániel Sándor Veres, Tamás Kói, Péter Hegyi, Gréta Szilvia Major, Miklós Garami, Ákos Gasparics, Arjan B. te Pas, Miklós Szabó
Journal: JAMA Pediatrics (2024)

Importance Intraventricular hemorrhage (IVH) has been described to typically occur during the early hours of life (HOL); however, the exact time of onset is still unknown. Objective To investigate the temporal distribution of IVH reported in very preterm neonates. Data Sources PubMed, Embase, Cochrane Library, and Web of Science were searched on May 9, 2024. Study Selection Articles were selected in which at least 2 cranial ultrasonographic examinations were performed in the first week of life to diagnose IVH. Studies with only outborn preterm neonates were excluded. Data Extraction And Synthesis Data were extracted independently by 3 reviewers. A random-effects model was applied. This study is reported following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. The Quality in Prognostic Studies 2 tool was used to assess the risk of bias. Main Outcomes And Measures The overall occurrence of any grade IVH and severe IVH among preterm infants was calculated along with a 95% CI. The temporal distribution of the onset of IVH was analyzed by pooling the time windows 0 to 6, 0 to 12, 0 to 24, 0 to 48, and 0 to 72 HOL. A subgroup analysis was conducted using studies published before and after 2007 to allow comparison with the results of a previous meta-analysis. Results A total of 21 567 records were identified, of which 64 studies and data from 9633 preterm infants were eligible. The overall rate of IVH did not decrease significantly before vs after 2007 (36%; 95% CI, 30%-42% vs 31%; 95% CI, 25%-36%), nor did severe IVH (10%; 95% CI, 7%-13% vs 11%; 95% CI, 8%-14%). The proportion of very early IVH (up to 6 HOL) after 2007 was 9% (95% CI, 3%-23%), which was 4 times lower than before 2007 (35%; 95% CI, 24%-48%). IVH up to 24 HOL before and after 2007 was 44% (95% CI, 31%-58%) and 25% (95% CI, 15%-39%) and up to 48 HOL was 82% (95% CI, 65%-92%) and 50% (95% CI, 34%-66%), respectively. Conclusion And Relevance This systematic review and meta-analysis found that the overall prevalence of IVH in preterm infants has not changed significantly since 2007, but studies after 2007 showed a later onset as compared with earlier studies, with only a small proportion of IVHs occurring before 6 HOL.
Estrogen Receptor Status of Contralateral Breast Cancers—Value Added or Pathology Without a Purpose?
Authors: Payal D. Shah
Journal: JAMA Network Open (2024)

Anne S. Reiner, MPH; Gordon P. Watt, PhD; Kathleen E. Malone, PhD; Charles F. Lynch, MD, PhD; Esther M. John, PhD; Julia A. Knight, PhD; Meghan Woods, MPH; Xiaolin Liang, MS; Marc Tischkowitz, MD, PhD; David V. Conti, PhD; Mark E. Robson, MD; Lene Mellemkjær, PhD; Sharon N. Teraoka, PhD; Patrick Concannon, PhD; Jonine L. Bernstein, PhD
Adherence to FDA Guidance on Pulse Oximetry Testing Among Diverse Individuals, 1996-2024
Authors: Kadija Ferryman, Deidra C. Crews, Emmanuel F. Drabo, Theodore J. Iwashyna, Odia Kane, John W. Jackson
Journal: JAMA (2024)

This study examines temporal trends in US Food and Drug Administration clearance summaries for pulse oximeters that report information about race and ethnicity and/or skin color or tone.
Where Are the Pediatricians?—Reply
Authors: Katherine A. Jordan, Priyanka Rao, Julie S. Byerley
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2025 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Herpes—Reply
Authors: Christine Johnston, Anna Wald
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2025 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Paradox of Burnout From Physicians’ Most Meaningful Roles
Authors: Colin P. West
Journal: JAMA Network Open (2024)

Masami Tabata-Kelly, MBA, MA; Xiaochu Hu, PhD; Michael J. Dill, MA; Philip M. Alberti, PhD; Karen Bullock, PhD, LICSW, APHSW-C; William Crown, PhD; Malika Fair, MD, MPH; Peter May, PhD; Pilar Ortega, MD; Jennifer Perloff, PhD
Herpes
Authors: Claude Bachmeyer
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2025 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Where Are the Pediatricians?
Authors: Timothy Phamduy
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Where Are the Pediatricians?
Authors: Ruirui Hou, Jian Ren
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brief Report: Evaluating Early-Stage Lung Cancer Survival Patterns in Patients at the Upper Age Limit for Lung Cancer Screening
Authors: Matthew T Warkentin, Martin C Tammemägi, Erik Vakil, Eric L R Bedard, Winson Y Cheung, Darren R Brenner, Alain Tremblay
Journal: Journal of Thoracic Oncology (2024)
Impaired Megakaryopoiesis due to Aberrant Macrophage Polarization via BTK/Rap1/NF-κB Pathway in Sepsis-induced Thrombocytopenia
Authors: Ziyan Zhang, Meng Zhou, Yaqiong Tang, Jiaqian Qi, Xiaoyan Xu, Peng Wang, Haohao Han, Tingting Pan, Xiaofei Song, Shuhui Jiang, Xueqian Li, Chengyuan Gu, Zhenzhen Yao, Qixiu Hou, Mengting Guo, Siyi Lu, Depei Wu, Yue Han
Journal: Molecular Therapy (2024)
Autologous transplantation of mitochondria/rAAV IGF-I platforms in human osteoarthritic articular chondrocytes as a novel therapeutic concept for human osteoarthritis
Authors: Gang Zhong, Wei Liu, Jagadeesh K Venkatesan, Dan Wang, Henning Madry, Magali Cucchiarini
Journal: Molecular Therapy (2024)

Despite various available treatments, highly prevalent osteoarthritis cannot be cured in patients. In light of evidence showing mitochondria dysfunction during the disease progression, our goal was to develop a novel therapeutic concept based on the transplantation of mitochondria as platforms to deliver recombinant adeno-associated viral (rAAV) gene vectors with a potency for osteoarthritis. For the first time to our best knowledge, we report the successful creation of a safe mitochondria/rAAV system effectively promoting the overexpression of a candidate insulin-like growth factor I (IGF-I) by administration to autologous human osteoarthritic articular chondrocytes versus control conditions (reporter mitochondria/rAAV lacZ system, rAAV-free system, absence of mitochondria transplantation) (up to 8.4-fold difference). The candidate mitochondria/rAAV IGF-I system significantly improved key activities in the transplanted cells (proliferation/survival, extracellular matrix production, mitochondria functions) relative to the control conditions (up to 9.5-fold difference), including when provided in a PF127 hydrogel for reinforced delivery (up to 5.9-fold difference). Such effects were accompanied with increased levels of cartilage-specific SOX9 and Mfn-1 (mitochondria fusion) and with decreased levels of Drp-1 (mitochondria fission) and proinflammatory TNF-α (up to 4.5-fold difference). This study shows the potential of combining the use of mitochondria with rAAV as a promising approach for human OA.
Modulation of Pain Sensitivity by Ascl1- and Lhx6-Dependent GABAergic Neuronal Function in Streptozotocin-Diabetic Mice
Authors: Sung-Min Hwang, Md Mahbubur Rahman, Eun Jin Go, Jueun Roh, Rayoung Park, Sung-Gwon Lee, Minyeop Nahm, Temugin Berta, Yong Ho Kim, Chul-Kyu Park
Journal: Molecular Therapy (2024)

Painful diabetic neuropathy commonly affects the peripheral nervous system in individuals with diabetes. However, the pathological processes and mechanisms underlying diabetic neuropathic pain remain unclear. We aimed to identify the overall profiles and screen for genes potentially involved in pain mechanisms using transcriptome analysis of the dorsal root ganglion of diabetic mice treated with streptozotocin (STZ). Using RNA sequencing, we identified differentially expressed genes (DEGs) between streptozotocin-treated diabetic mice and controls, focusing on altered GABAergic neuron-related genes and inflammatory pathways. Behavioral and molecular analyses revealed a marked reduction in GABAergic neuronal markers (GAD65, GAD67, VGAT) and increased pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in the diabetic group compared to controls. Intrathecal administration of lentiviral vectors expressing transcription factors Ascl1 and Lhx6 reversed pain hypersensitivity and restored normal expression of GABAergic genes and inflammatory mediators. Protein-protein interaction (PPI) network analysis revealed five key proteins influenced by Ascl1 and Lhx6 treatment, including those in the JunD/FosB/C-fos signaling pathway. These findings suggest that Ascl1 and Lhx6 mitigate diabetic neuropathic pain by modulating GABAergic neuronal function, pro-inflammatory responses, and pain-related channels (TRPV1, Nav1.7). These results provide a basis for developing transcription factor-based therapies targeting GABAergic neurons for diabetic neuropathic pain relief.
Functional screening identifies miRNAs with a novel function inhibiting Vascular Smooth Muscle Cell proliferation
Authors: Julie Rodor, Eftychia Klimi, Simon D Brown, Georgios Krilis, Luca Braga, Nadja A R Ring, Margaret D Ballantyne, Despoina Kesidou, Aurelie Nguyen Dinh Cat, Vladislav Miscianinov, Francesca Vacante, Katarina Miteva, Matthew Bennett, Abdelaziz Beqqali, Mauro Giacca, Serena Zacchigna, Andrew H Baker
Journal: Molecular Therapy (2024)