tbuckley/cabot-search huggingface dataset:
Bendamustine with Rituximab Is Safe and Effective As FRONT LINE Therapy in Elderly B-CLL Patients. an ITALIAN RETROSPECTIVE MULTICENTER Experience
Authors: Luca Laurenti, Francesco Autore, Idanna Innocenti, Barbara Vannata, Maria Cantonetti, Maria Ilaria Del Principe, Francesca Romana Mauro, Anticoli Borza Paola, Velia Bongarzoni, Stefania Ciolli, Riccardo Boncompagni, Mariarita Sciumé, Daniele Vincenti, Francesco Ghio, Nadia Cecconi, Vincenzo Pitini, Patrizia Mondello, Maria Rosa Lanza Cariccio, Alessandro Gozzetti, Giovanni D'Arena, Roberta Murru, Nicola Piccirillo, Mario Petrini, Agostino Cortelezzi, Giovanni Del Poeta, Robin Foà, Simona Sica
Journal: Blood (2014)
Abstract 3179: Cardiospheres Derived From Infarcted Myocardium Have the Potential for Myocardial Regeneration
Authors: Jianqin Ye, Andrew Boyle, Henry Shih, Richard E Sievers, William Grossman, Yerem Yeghiazarians
Journal: Circulation (2009)

Background: Cardiospheres (CSs) represent one type of cardiac stem cells. However, the availability of CSs from infarcted myocardium is unknown. We tested the hypothesis that acute myocardial infar...
Gifttiere und ihre Giftigkeit.
Authors: E. N. Pavlovskiĭ
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictors of outcome and treatment decisions of older patients with stage III non-small cell lung cancer
Authors: D. D. Luong, D. Poon, G. Gao, D. Boulware, G. Simon, M. Extermann
Journal: Journal of Clinical Oncology (2007)

19574 Background: In treating Stage III non-small cell lung cancer in the elderly, oncologists often empirically adjust treatment without clear guidelines. Identifying patient characteristics that impact prognosis will aid in creating better treatment algorithms in this patient population. Methods: A retrospective analysis was done on older patients (age &gt; 70) treated for Stage III NSCLC (excluding “wet” IIIB) at the H. Lee Moffitt Cancer. Cox multivariate analysis identified variables impacting progression free survival, overall survival, treatment chosen, treatment interruptions, and hospitalizations. Correlation and regression tree analysis (CART) was performed to create potential decision making models. Results: 213 patients were evaluable. Multivariate analysis identified ECOG performance status (hazard ratio = 1.52, p = 0.005) and nodal status (HR = 1.36, p = 0.001) as negatively associated with PFS while BMI (HR = 0.96, p = 0.02) was positively associated. ECOG performance status (HR = 2.26, p &lt; 0.0001), nodal status (HR = 1.18, p = 0.08), and CIRS3 (having a comorbidity classified as severity 3; HR = 1.33, p = 0.02) were negatively associated with OS. BMI (HR = 0.95, p = 0.002) and CIRSmean (mean CIRS-G severity score; HR 0.61, p = 0.01) were positively associated with OS. These variables were also identified as the most significant splitters, along with smoking status and pulmonary function, in CART analyses. Trees using PFS and OS as outcomes were created with receiver operating curves (ROC) ranging from 0.64–0.75. A CART analysis targeting treatment modality chosen had ROCs ranging from 0.49–0.78. Conclusions: Our multivariate analysis found ECOG performance status, nodal status, and severe medical comorbidity as negatively associated with survival. Unexpectedly, BMI (at initial treatment), independent of weight loss, was found to be positively associated. Also, the splitter variables identified by CART analysis were very similar to the general multivariate model, but the weights differed in the various analyses and subgroups of patients. The CART analyses suggest that we can create decision making models with a range of applicability comparable to those commonly considered useful for clinical guidelines, i.e. about 60% of straightforward application. No significant financial relationships to disclose.
A retrospective study of parameters influencing survival after surgical resection of lung metastases of bone and soft tissue sarcomas
Authors: S. Piperno-Neumann, K. Homicsko, S. Mussot, P. Anract, V. Laurence, J. Pierga, L. Mignot, A. Chapelier
Journal: Journal of Clinical Oncology (2009)

10541 Background: Due to the high rate of isolated lung metastases of sarcomas, a multidisciplinary approach combining chemotherapy with pulmonary metastasectomy (PM) is helpful to achieve R0 resection and try to increase progression free survival (PFS) and overall survival (OS). The aim of this retrospective study is to describe the clinical and tumor features of 70 consecutive operated patients and to identify the factors influencing survival. Methods: 70 patients undergoing PM at Foch Hospital or CCML between 1995 and 2006 were identified, with follow-up (FU) for a minimum of 3 years after last PM. Statview program has been used to create survival curves, Cox proportional hazard model for multivariate analysis. Results: 64 patients had grade II/III sarcomas of mainly lower limb origin.15 patients had synchronous lung metastases, 35 showed bilateral lesions (mean number of 4, mean size of 12 mm). No patient had extrapulmonary disease at the time of PM. 51% were primary bone sarcomas (24 osteo, 9 Ewing, 3 chondro) and 49 % were soft tissue sarcomas (including 12 synovial, 9 leio). The primary tumor treatment consisted in conservative surgery in 58 patients (83%). 49 patients received neo and/or adjuvant chemotherapy, 22 patients had postoperative radiotherapy. All patients underwent PM: 1 pneumonectomy, 15 lobectomy and 54 wedge resection. 21 patients required bilateral PM. The resection margins were classified R0/R1/R2 in 54/16/0 patients, R0 was confirmed in 44 by CT scan in a month after PM. With a median FU from diagnosis of 7.7 years, the median OS for all patients reached 59 months, and the median survival after metastasectomy (OSPM) 31 months. The 5-year OS and OSPM rates were 77% and 59% respectively. The mean PFS was 20 months. 25 patients underwent subsequent PM for recurrent lung metastases, 30 are still alive. On univariate analysis, primary high grade, DFI&gt;24 months, number of metastases&gt;3 and largest diameter&gt;25 mm were significant negative factors for OS. Multivariate analysis confirmed the importance of high grade, DFI, and size of metastases for OS. R0 was associated with prolonged PFS after PM. Conclusions: Accurate patient selection and technical aspects of PM are related to optimal R0 rate. DFI may be a surrogate marker for tumor biology. No significant financial relationships to disclose.
International Symposium on Retroviruses and Human Pathology
Authors: Robert C. Gallo, Dominique Stehelin, Oliviero E. Varnier, Istituto nazionale per la ricerca sul cancro
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article International Symposium on Retroviruses and Human Pathology Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 4, April 1984, Page 964, https://doi.org/10.1093/jnci/72.4.964-a Published: 01 April 1984
Abstract 557: The Utility of Serial Enzymes to Rule out Myocardial Injury in Pateints with Non-Critical Disease by CT Angiography
Authors: Brian J O’Neil, Patrick Medado, James Wegner, Michael Gallagher, Gil Raff
Journal: Circulation (2008)

Coronary Computed Tomography Angiography (CCTA) is a diagnostic test shown to have a high negative predictive value for coronary artery disease and major cardiac events at three months. Many emergency department, (ED), protocols mandate serial enzymes prior to discharge to capture possible myocardial injury even with normal CCTAs. Determine the value of serial cardiac enzymes in low risk patients (TIMI Risk Score &lt;3) presenting to the ED with chest pain who have a normal or intermediate CTA, (&lt; 25% stenosis). 307 patients received CCTA as part of clinical trials. All patients presented to the ED with suspected acute coronary syndrome and had a TIMI Risk &lt;3, non diagnostic ECGs and negative initial enzymes. All patients had serial enzymes sampling at least 4 hours apart per protocol. Structured telephone follow up and chart review was completed at 30 and 90 days post ED visit. All data was analyzed using descriptive statistics. 68% of all CTA patients were classified as normal &lt; 25% stenosis, with another 8% considered intermediate &lt; 50% stenosis. Average time between blood collection was 4:30+/−1:28. All patients had normal serial Troponin I values (Normal &lt;0.05 ng/mL) with no appreciable delta over time. 39 patients had an increase in Myoglobin values with 10 having a delta ≥20% but &lt;50%, none of these patients had a level above our normal range (&lt; 98 ng/ml). Only one myoglobin values was above our normal limits, but did change over time. There were no deaths or adverse cardiac events at 90 days in this population. In this study of low risk patients with suspected cardiac ischemia (TIMI &lt;3) and a normal or intermediate CCTA, serial cardiac enzymes have no utility.
Abstract 847: Effect of Statins on Arterial Characteristics in Familial Hypercholesterolemia: A Meta-Analysis of Longitudinal Studies
Authors: Constantina Masoura, Konstantinos Aznaouridis, Christos Pitsavos, Ioannis Skoumas, Charalambos Vlachopoulos, Christodoulos Stefanadis
Journal: Circulation (2009)

Objectives: We conducted this research to calculate quantitative estimates for the effect of statins on arterial structural and functional characteristics in patients with familial hypercholesterol...
Abstract 10566: Trans-fatty Acid Accelerates Thrombus Formation In Vivo Through Aggravating Anti-thrombogenic Phenotype of Vascular Endothelial Cells
Authors: Kensuke Kondo, Tatsuro Ishida, Tomoyuki Yasuda, Junichiro Yamamoto, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Kenta Mori, Hideto Nakajima, Ryuji Toh, Kenichi Hirata
Journal: Circulation (2013)

Purpose: Epidemiological studies revealed that excessive intake of trans-fatty acids (TFA) increase the risk of myocardial infarction. However, the role of TFA in thrombus formation has been incomp...
Evaluating the quality of life of patients with perennial allergic rhinitis with the Rhinoconjunctivitis Quality of Life Questionnaire and Short-Form 36
Authors: H. H. Chng, A. Ernest, C. Y. Tang, C. L. Yeak, S. M. Saurajen, K. H. Mok, J. K. Siow, W. C. Chee, R. Seshadri, S. B. Yeo, L. C. Khoo, C. Y. Lee, K. P. Leong
Journal: Journal of Allergy and Clinical Immunology (2001)
Abstract 3693: Genetic Variability Of Nitric Oxide Synthase And The Risk For Myocardial Infarction: Evidence For Interactions With Inflammatory Response And Endothelial Injury During The Acute Phase Of Myocardial Infarction
Authors: Charalambos Antoniades, Dimitris Tousoulis, Carmen Vasiliadou, Kyriakoula Marinou, Nikolas Koumallos, Christos Pitsavos, Elli Stefanadi, Costas Tentolouris, Costas Tsioufis, Christodoulos Stefanadis
Journal: Circulation (2006)

Background: Genetic polymorphism G894T on endothelial nitric oxide synthase (eNOS) has been associated with increased cardiovascular risk. However its role during the acute phase of myocardial infa...
Soviet Russia As I Saw It: Its Accomplishments. Its Crimes and Stupidities.
Authors: William J. Robinson
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prenatal Exposure to Perfluoroalkyl Acids and Serum Testosterone Concentrations at 15 Years of Age in Female ALSPAC Study Participants
Authors: Mildred Maisonet, Antonia M. Calafat, Michele Marcus, Jouni J.K. Jaakkola, Hany Lashen
Journal: Environmental Health Perspectives (2015)

Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator-activated receptor alpha (PPARα) subtype activity, which influences lipid metabolism. Because cholesterol is the substrate from which testosterone is synthesized, exposure to these substances has the potential to alter testosterone concentrations.We explored associations of total testosterone and sex hormone-binding globulin (SHBG) concentrations at age 15 years with prenatal exposures to PFOS, PFOA, perfluorohexane sulfonic acid (PFHxS), and perfluoronanoic acid (PFNA) in females.Prenatal concentrations of the perfluoroalkyl acids (PFAAs) were measured in serum collected from pregnant mothers at enrollment (1991-1992) in the Avon Longitudinal Study of Parents and Children (ALSPAC). The median gestational age when the maternal blood sample was obtained was 16 weeks (interquartile range, 11-28 weeks). Total testosterone and SHBG concentrations were measured in serum obtained from their daughters at 15 years of age. Associations between prenatal PFAAs concentrations and reproductive outcomes were estimated using linear regression models (n = 72).Adjusted total testosterone concentrations were on average 0.18-nmol/L (95% CI: 0.01, 0.35) higher in daughters with prenatal PFOS in the upper concentration tertile compared with daughters with prenatal PFOS in the lower tertile. Adjusted total testosterone concentrations were also higher in daughters with prenatal concentrations of PFOA (β = 0.24; 95% CI: 0.05, 0.43) and PFHxS (β = 0.18; 95% CI: 0.00, 0.35) in the upper tertile compared with daughters with concentrations in the lower tertile. We did not find evidence of associations between PFNA and total testosterone or between any of the PFAAs and SHBG.Our findings were based on a small study sample and should be interpreted with caution. However, they suggest that prenatal exposure to some PFAAs may alter testosterone concentrations in females.
Carbamazepine treatment for benzodiazepine withdrawal
Authors: R K Ries, P P Roy-Byrne, N G Ward, V Neppe, S Cullison
Journal: American Journal of Psychiatry (1989)

Nine patients were given carbamazepine before rapid discontinuation of benzodiazepines. Most patients had had long-term benzodiazepine treatment and had abused benzodiazepines; five had taken high doses. All patients tolerated rapid discontinuation well and none developed significant withdrawal symptoms.
DD3, a very sensitive and specific merker to detect prostate tumors. Reply to: Gandino O, Santulli M, Cardillo MR, Stigliano A, Toscano V. Correspondence re: J.B. de Kok et al.
Authors: G.W.C.T. Verhaegh, J.B. de Kok, D. Hessels, F.P. Smit, J.A. Schalken
Journal: Cancer Research (2003)
Intracellular trafficking of bio-nanocapsule–liposome complex: Identification of fusogenic activity in the pre-S1 region of hepatitis B virus surface antigen L protein
Authors: Masaharu Somiya, Yasuo Sasaki, Takashi Matsuzaki, Qiushi Liu, Masumi Iijima, Nobuo Yoshimoto, Tomoaki Niimi, Andrés Daniel Maturana, Shun'ichi Kuroda
Journal: Journal of Controlled Release (2015)
Vertebrate Sexual Cycles
Authors: W. S. Bullough
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dental Science and Dental Art.
Authors: Samuel Morris Gordon
Journal: Annals of Internal Medicine (1940)

One of the important dental publications in 1938, this book is of special value and interest to both the dental and the medical profession. It is concerned with fundamental, basic and scientific principles of dental practice rather than with technical details. For the dentist it should strengthen and clarify the scientific basis of his procedure and for the physician it will clear up many traditional errors. There are twentytwo chapters, supplied by nineteen authors, the editor, Dr. Gordon, contributing the eleventh chapter, on calcium and phosphorus compounds in relation to dental nutrition. Each chapter is an independent treatise, but all are so admirably selected and so integrated by cross references that the book constitutes a unit. The first and second chapters, on tooth development and experimental dental histophysiology, by Isaac Schour, deal with the calcification pattern of the teeth, which, like the developmental rings of the tree, records the experiences
Sensitivity Chest Diseases.
Authors: Maurice Coleman Harris, Norman Shure
Journal: Annals of Internal Medicine (1965)

South, New York 10016, 1964. One of the questions to be answered for virtually every book is the nature of the reader for whom it would be best suited. Another question is whether an additional book might be necessary or desirable to supplement the scope of the book in question\p=m-\as a sort of textual magnifying glass. A general caution is appropriate here: an incomplete account may at times be as hazardous as a false account\x=req- the omission of relevant material in an incomplete account has the same effect as an account which by its silence can be misleading. This caution is intended as a general note in this age of the quick-and-easy summaries. While Cutting's Handbook of Pharmacology is not and cannot be even relatively comprehensive, it signals the important properties of a substance by its excellent organization. The usual pattern by which drugs or groups of drugs (as ganglionic blocking agents for example) are described is under the following subheadings: history; chemistry (including structural formulae); action; mechanism (which I consider quite an important subhead
Intramural gastric abscess following laparoscopic paraesophageal hernia repair
Authors: Will Cole, Stanley Zagorski
Journal: Endoscopy (2015)

A 46-year-old woman underwent laparoscopic paraesophageal hernia repair for an intrathoracic stomach ([Fig. 1]). After the surgery, she was discharged from the hospital in good condition, but 24 days later, she re-presented with progressive nausea, vomiting, and persistent globus sensation. Physical examination revealed mild tenderness in the left upper quadrant. Laboratory findings included a leukocytosis, mild electrolyte abnormalities, and a low serum albumin level.
Infectious and immunosuppressive complications of purine analog therapy.
Authors: B D Cheson
Journal: Journal of Clinical Oncology (1995)

PURPOSE The purine analogs fludarabine, cladribine, and pentostatin are active agents in the treatment of indolent lymphoid malignancies. This report reviews the pattern, severity, and consequences of the immunosuppression and myelotoxicity associated with these agents. METHODS The literature was searched using MedLine and Cancerline, as well as the bibliographies of published reports through the winter of 1994 and 1995. RESULTS Each of these drugs induces profound lymphocytopenia. A marked decrease in CD4 cells may persist for several years, while other mononuclear-cell populations recover more rapidly. The spectrum of infections encountered in these patients appears to be altered to include a wide range of opportunistic organisms. Factors that increase the risk of these infections include concurrent corticosteroids, extensive prior therapy, particularly with another purine analog, and poor response to purine analog treatment. CONCLUSION Because of the frequency of life-threatening infections with unusual pathogens that may occur in patients treated with purine analogs, aggressive and early diagnostic evaluation and appropriate use of myeloid growth factors may be necessary to ensure appropriate antimicrobial therapy.