tbuckley/cabot-search huggingface dataset:
Abstract 9245: Incident Atrial Fibrillation is Associated with an Increased Risk of Sudden Cardiac Death in Hypertensive Patients During Antihypertensive Therapy: The LIFE Study
Authors: Peter M Okin, Kristian Wachtell, Darcy A Hille, Sverre E Kjeldsen, Björn Dahlöf, Richard B Devereux
Journal: Circulation (2011)

Background: Incident atrial fibrillation (AF) is associated with an increased risk of mortality in the general population and after myocardial infarction. Prevalent AF is associated with an increased risk of appropriate device therapies for ventricular arrhythmias in patients with ICDs and with a higher rate of sudden cardiac death (SCD) in advanced heart failure patients. However, whether hypertensive patients with incident AF are at higher risk of SCD has not been examined. Methods and Results: The predictive value of incident AF for SCD was examined in 8831 hypertensive patients with ECG left ventricular hypertrophy (LVH) with no history of AF, in sinus rhythm on their baseline ECG, who were randomly assigned to losartan- or atenolol-based treatment. During 4.8±0.9 years mean follow-up, new-onset AF occurred in 701 patients (7.9%) and SCD in 151 (1.7%). SCD was significantly more frequent in patients with new AF than in those without (3.6 vs 1.5%, p&lt;0.001). In univariate Cox analyses, new-onset AF, treated as a time-varying covariate, was associated with a subsequent 113% higher risk of SCD (HR 2.13, 95% CI 1.31-3.44, p=0.002). In multivariate Cox analyses adjusting for randomized treatment, age, sex, race, body mass index, diabetes, history of heart failure, myocardial infarction, ischemic heart disease, stroke, peripheral vascular disease, smoking, serum total and HDL cholesterol, creatinine, glucose, urine albumin/creatinine ratio and for incident MI, in-treatment heart rate, diastolic and systolic pressure, Cornell voltage-duration product and Sokolow-Lyon voltage LVH treated as time-varying covariates, incident AF remained associated with a 74% increased risk of SCD (HR 1.74, 95% CI 1.05-2.91, p=0.033). Conclusions: The development of new-onset of AF identifies hypertensive patients at increased risk of SCD, independent of the higher prevalence of risk factors in patients with new AF, treatment effects, in-treatment blood pressure and the established predictive value of in-treatment ECG LVH and heart rate for SCD in this population.
Abstract 18813: Routine Follow Up Coronary Angiography versus Clinical Follow Up only in Patients Undergoing Elective Percutaneous Coronary Intervention with Drug-eluting Stents
Authors: Seung Woon Rha, Ji Young Park, Byoung Geol Choi, Kanhaiya L. Poddar, Kang Yin Chen, Sureshkumar Ramasamy, Yong Jian Li, Yun Kyung Kim, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Circulation (2010)
Urobilin Physiology and Pathology
Authors: Philip D. Mcmaster, Robert Elman
Journal: Annals of Internal Medicine (1927)

Article1 August 1927Urobilin Physiology and PathologyPHILIP D. MCMASTER, M.D., ROBERT ELMAN, M.D.PHILIP D. MCMASTER, M.D.Search for more papers by this author, ROBERT ELMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-2-68 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical interest in urobilin has always been great, yet at the present day the conclusions confidently drawn by workers with the substance far outrun actual knowledge of it. Analysis of the previous literature makes clear that the hypotheses of the origin of this pigment show no semblance of accord (1, 2). Every conceivable organ and tissue has been championed by one author or another as the sole site of origin of urobilin.In the course of studies upon the physiology of bile made in this laboratory, methods were described (3, 4) whereby animals can be totally, partially and intermittently deprived...References(1) MEYER-BETZ F, Ergebn. inn. Med u. Kinderheilk., 1913, xii, 733. Google Scholar(2) EPPINGER H, Die Hepato-lienalen Erkrankungen, Berlin, 1920, 76. Google Scholar(3) ROUSMCMASTER PPD, J. Exp. Med., 1923, xxxvii, 11. CrossrefGoogle Scholar(4) MCMASTERELMAN PDR, J. Exp. Med., 1925, xli, 513. CrossrefGoogle Scholar(5) ELMANMCMASTER RPD, J. Exp. Med., 1925, xli, 503. CrossrefGoogle Scholar(6) MALY R, Ann. Chem., 1872, clxiii, 77. CrossrefGoogle Scholar(7) MULLER F, Verhandl. Schles. Ges. vaterl. Cult., January 15, 1892. Google Scholar(8) KAMMERERMILLER HK, Deutsch. Arch. klin, Med., 1923, cxli, 318. Google Scholar(9) MCMASTERELMAN PDR, J. Exp. Med., 1925, xli, 719. CrossrefGoogle Scholar(10) ELMANMCMASTER RPD, J. Exp. Med., 1925, xlii, 99. CrossrefGoogle Scholar(11) ELMANMCMASTER RPD, J. Exp. Med., 1925, xlii, 619. CrossrefGoogle Scholar(12) MCMASTERELMAN PDR, J. Exp. Med., 1926, xliii, 753. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York*Presented at the Cleveland Clinical Week of the American College of Physicians, February 23, 1927.†From the Laboratories of the Rockefeller Institute for Medical Research. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHistorical and Clinical Aspects of Bile PigmentsHämolyse und Hämoglobinabbau 1 August 1927Volume 1, Issue 2Page: 68-73KeywordsBileClinical pathology ePublished: 1 December 2008 Issue Published: 1 August 1927 PDF downloadLoading ...
Tuberculosis detection in children and adolescents using diagnostic testing based on tuberculosis recombinant protein E SAT6-CFP10 (diaskintest)
Authors: Ludmila Slogotskaya, Elena Ovsyankina, Vitaliy Litvinov, Yakov Kochetkov, Petr Seltsovsky, O. Senchikhina, L. Stakheeva, Dmitriy Koudlay
Journal: European Respiratory Journal (2011)

Background:  Until recently, the tuberculin skin test (TST) has been the only diagnostic method for latent tuberculosis infection (LTBI). However, the specificity of TST is low, because the purified protein derivative (PPD) used for TST contains numerous M. tuberculosis (MTB) antigens that are almost identical to BCG antigens or similar to non-TB mycobacterium (NTM) antigens. Of those 99% BCG vaccinated in Russia it is very difficult to diagnose LTBI. DIASKINTEST (DST) consists of two MTB-specific antigens - ESAT-6 and CFP-10, which are absent in all  M. bovis BCG  substrains and in most of NTM antigens. Aim was to evaluate to evaluate the role of DST in TB detection.   Method:  1675 children and adolescents with conversed tuberculin reaction, reaction size increased by more than 6 mm, hyperergy, TB contacts (social and household) received the Mantoux test with 2 TU PPD-L and DST 0.2 mkg/0.1 ml.   Result:  95,8% -TST-positive. 349 (20,8%) - DST- positive, all - chest X-rayed plus computer tomography (CT). TB was diagnosed in 148 (42,4%). Out of them 6 were initially DST negative but after 3 months DST was repeated and resulted positive- active TB was diagnosed. In 19 (5,5%) TB was in the calcination phase. 9 TB contacts with established TB were DST-negative. All had BCG vaccination. 4 children one year old, probably, had not developed immunity. Two had contacts with TB/HIV parents.   Conclusion:  DST allows detecting TB in 42,4% of cases. DST negative reaction could be in early aged TB patients – when immune response has not been developed yet. DST positive reaction may develop later in vaccinated children.
Abstract 2924: Association of <i>NOS1AP</i> Genetic Variants with QT Interval Duration in Families from the Diabetes Heart Study
Authors: Allison B Lehtinen, Christopher Newton-Cheh, Julie T Ziegler, Carl D Langefeld, Barry I Freedman, Kurt R Daniel, David M Herrington, Donald W Bowden
Journal: Circulation (2007)

Background: Prolongation of the electrocardiographic QT interval is a risk factor for sudden cardiac death (SCD) in unselected samples as well as in post-myocardial infarction patients or those with diabetes. Common genetic variants in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene have been reported to be associated with QT interval duration in individuals of European ancestry. We sought to replicate the association of NOS1AP variants with QT interval duration in pedigrees enriched for type 2 diabetes mellitus (T2DM). Methods and Results: Two single nucleotide polymorphisms (SNPs) in the NOS1AP gene, rs10494366 and rs10918594, were genotyped in a collection of 937 European Americans (EAs) and 177 African Americans (AAs) in 450 pedigrees containing at least two siblings with T2DM. An additive genetic model was tested for each SNP in ancestry-specific analyses using SOLAR in the total sample and in the diabetic subset (EA n=778, AA n=159), with and without exclusion of QT-altering medications. In the EA individuals, rs10494366 minor allele homozygotes had an 8.9 msec longer mean QT interval compared to major homozygotes (additive model p=4.4x10 -3 ); rs10918594 minor homozygotes had a 12.9 msec longer mean QT interval compared to major homozygotes (p=9.9x10 -5 ). Excluding users of QT-altering medications in the diabetic-only EA sample (n=514) strengthened the association despite the reduction in sample size (20.6 msec difference, p=2.0x10 -5 ; 23.4 msec difference, p=8.9x10 -7 , respectively). No association between the NOS1AP SNPs and QT interval duration was observed in the limited number of AA individuals examined. Conclusions: Two NOS1AP SNPs are strongly associated with QT interval duration in a predominately diabetic EA sample. Stronger effects of NOS1AP variants in diabetic individuals compared to previously reported unselected samples suggest that this patient subset may be particularly susceptible to genetic variants that influence myocardial depolarization and repolarization as manifest in the QT interval.
Cytokine gene polymorphisms and the risk of deep venous thrombosis.
Authors: F. Pieroni, Francisco Humberto de Abreu Maffei, C. E. Piccinato, A. Biscaro, V. M. Morelli, D. M. Lourenco, M. H. Tavella, M. A. Zago, R. F. Franco
Journal: Blood (2000)
Abstract 3390: Impairment of Post-ischemic Neovascularization in Mice Lacking IQGAP1, an Actin-binding Scaffold Protein: Role in Macrophage Infiltration and ROS production
Authors: Norifumi Urao, Ronald McKinney, Tohru Fukai, Masuko Ushio-Fukai
Journal: Circulation (2008)

Neovascularization is important repair mechanism in response to ischemic injury and its process is in part dependent on reactive oxygen species (ROS). IQGAP1, an actin-binding scaffold protein, is key regulator for actin cytoskeleton and motility. We demonstrated that IQGAP1 is expressed in endothelial cells (ECs) and mediates VEGF-induced ROS production and migration of cultured ECs. However, its role in postnatal neovascularization is unknown. Here we show that neovascularization induced by hindlimb ischemia is significantly inhibited in IQGAP1-deficient mice as evaluated by laser Doppler blood flow (38%), capillary density (48%) and alpha-actin positive arterioles (68%). In wild-type (WT) mice, western and immunofluorescence analysis reveal that IQGAP1 protein expression in ischemic tissues is significantly increased at Mac3+ macrophages and lectin+ capillary-like ECs at 3 days and 7 days after ischemia, respectively, which is associated with increased superoxide production. Of note, macrophage infiltration is important for post-ischemic revascularization. Mice lacking IQGAP1 show significant decrease in the number of infiltrated Mac3-positive macrophage and superoxide production in ischemic muscles (30% and 52%, respectively) as compared to WT mice. Numbers of inflammatory cells and cKit+/Flk1+ endothelial progenitor cells in peripheral blood are not affected in these knockout mice. Moreover, thioglycollate-induced peritoneal leukocyte recruitment and accumulation are significantly inhibited in IQGAP1-deficient mice (53%), whereas white blood cell number is not changed. In vitro, peritonitis-elicited (activated) macrophages obtained from IQGAP1-deficient mice show impaired polarization of actin, as visualized by phalloidin staining as well as complete inhibition of migration towards stromal derived factor-1 and VEGF, as measured by modified Boyden-chambered method. In summary, IQGAP1 plays a key role in reparative neovascularization in response to tissue ischemia by regulating not only ECs but also macrophage migration/infiltration as well as ROS production in the vessel growth area. Thus, IQGAP1 is a potential therapeutic target to promote neovascularization in ischemic cardiovascular diseases. This research has received full or partial funding support from the American Heart Association, AHA National Center.
Abstract 2817: The Impact of Exercise-Induced Changes in Intraventricular Dyssynchrony on the Functional Improvement in Patients with Non-Ischemic Cardiomyopathy
Authors: Soo-Jin Kang, Hong-Seok Lim, Un-Jung Choi, Byung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Gyo-Seung Hwang, Seung-Jea Tahk, Joon-Han Shin
Journal: Circulation (2007)

Background: We studied whether dynamic changes in LV asynchrony may affect the functional improvement of LV in medically treated patients with non-ischemic cardiomyopathy (CMP). Methods: Supine bicycle exercise was performed in 41 patients (age 51±12 years, EF 33±8%). Using tissue Doppler imaging, the average of peak systolic velocities of 6 basal LV segments were obtained at rest (V b ) and peak exercise (V p ). ΔV was calculated by [V p -V b ], reflecting the contractile reserve. Dyssynchrony index (SD 4 ) was defined as the standard deviation of the time to peak systolic velocities at 4 basal &amp; mid segments of septum and lateral wall on apical 4 chamber view. ΔSD 4 was calculated as [peak exercise SD 4 - resting SD 4 ]. Follow-up echocardiography was done in 35 patients after medication for 11.2±4.2 months. Functional changes of LV was assessed by ΔEF FU and %change of ESV (ΔESV FU ). Results: Baseline SD 4 was 24±17 ms. During exercise, SD 4 increased in 24 patients (ΔSD 4 =+14±12 ms), whereas decreased in 17 patients (ΔSD 4 =-17±14 ms). ΔSD 4 correlated with ΔV (r=-0.36, p=0.021) and exercise-induced increase in MR (ΔJet/LA area (%); r=0.31, p=0.05 and ΔPISA radius at 40cm/s of aliasing v; r=0.46, p=0.003). ΔV and ΔPISA were related to the follow-up change of LV function. Especially, ΔSD 4 independently correlated with ΔEF FU (β= -0.82, p&lt;0.001) and also with ΔESV FU (β= 0.40, p=0.021)(Fig ). However, baseline SD 4 didn’t affect ΔEF FU . On ROC curve analysis, sensitivity and specificity of ΔSD 4 &lt;4.0 ms were 82% and 78% for predicting ΔEF FU &gt;+5% and 70% and 63% for predicting ΔESV FU &lt;-15%. Conclusion : Exercise-induced changes in dyssynchrony (ΔSD 4 ) can predict the functional improvement in non-ischemic CMP.
Updated Results Confirm Favorable Outcome of Immunocompetent Patients with Primary CNS Lymphoma Treated By C5R Protocol in Combination with Intravenous Rituximab and Intrathecal Liposomal Cytarabine: A Multicentric Prospective Phase 2 Study of the Lymphoma Study Association (LYSA)
Authors: Herve Ghesquieres, Herve Tilly, Anne Sonet, Jehan Dupuis, Alexia Schwartzmann, Emmanuelle Nicolas-Virelizier, Marc Andre, Fabienne Trullemans, Emmanuel Fleck, Sami Boussetta, Franck Morschhauser, Jean-Yves Blay
Journal: Blood (2014)
Abstract 15138: Systematic Review&Meta-Analysis of Infective Endocarditis Microbiology Over 5 Decades
Authors: Leandro Slipczuk, Nicolas J Codolosa, Davila Carlos, Abel Romero-Corral, Gregg S Pressman, Vincent M Figueredo
Journal: Circulation (2012)

CONTEXT: Data are conflicting regarding changes in the microbiology of infective endocarditis (IE) over time.  METHODS: We searched, without language restrictions, PubMed, MEDLINE and EMBASE from 1960 until 2011. Search was supplemented with references from reviewed articles and correspondence with other researchers. We included studies reporting IE microbiology, time-frame, population, and IE definition. We excluded studies limited to specific sub-groups. Also included were data from our Institution from 2000 to 2010. Quality of papers was assessed as recommended by Khan and Stroup. RESULTS: 161 studies and 27,354 patients were included. In hospital-based studies (n=143; 23,877 patients), Staphyloccocal IE increased over time, with significant increases in 1) coagulase-negative Staphyloccocus over 5 decades (2% to 10%; p
Phase I trial of volasertib (BI 6727), a polo-like kinase 1 (Plk1) inhibitor, in combination with cisplatin or carboplatin in patients with advanced solid tumors.
Authors: A. Deleporte, H. Dumez, A. Awada, J. Costermans, M. Meeus, T. Berghmans, M. Ould Kaci, N. Juhel, A. Berge, T. Taube, P. Schöffski
Journal: Journal of Clinical Oncology (2011)

3031 Background: Volasertib (V) is a potent and highly selective inhibitor of Plk1, a key regulator of cell-cycle progression. Preclinical data showed that V and Cisplatin (Cis) or carboplatin (Ca) combination may confer additional benefit. Methods: Sequential cohorts of 3 to 6 patients (pts) received a single 2-hour infusion of V in combination with Cis (arm A) or Ca (arm B), on day 1 every 3 weeks. Cis and Ca were given for up to 6 cycles (Cy), V was continued until disease progression or unacceptable toxicity. Maximum tolerated dose (MTD) is defined as the highest dose at which ≥1 pt out of a maximum (max) of 6 experienced Dose Limiting Toxicity (DLT) during Cy 1. Results: As of January 14, 2011, 36 pts (18 each arm) were treated. Pt characteristics were (arm A/B): median age 52/57.5 years, male 39/72%, ECOG PS 0: 44/39%, PS 1: 50/61%. Tumors were: NSCLC (22%), sarcoma (14%), colorectal cancer (11%), melanoma (11%), other (42%). Pts received the combination therapy for a median [range] of 4 Cy [1-6] in arm A and 2 Cy [2-6] in arm B and V for a max of 15 and 11 Cy in arms A and B respectively. Only 2 DLTs (Cy 1) were observed, 1 in arm A at DL A5 (grade 4 CTC version 3 neutropenia for >7 days) and 1 in arm B at DL B4 (grade 4 thrombocytopenia). The most frequent drug related grade 3 or 4 AEs by pt were (% of pts arm A/B): anemia 6/6, neutropenia 33/33, thrombocytopenia 6/22, febrile neutropenia 6/0, vomiting 6/0, fatigue 11/6. Grade 1/2 QTc prolongation was observed in 2 pts (DL A2, B4). MTD in both arms has not yet been reached at predefined DLs. Three partial responses were seen: 2 in pts with CHOP-resistant follicular dendritic reticulum cell sarcoma in arm A (DL A2, A4) and 1 pt with heavily-pretreated head and neck carcinoma in arm B (DL B4). Stable disease was reported in 50% and 39% of pts in arm A and B respectively, and 5 and 3 pts had long stabilization (> 6 Cy). Conclusions: V in combination with Cis or Ca is well tolerated and demonstrates preliminary evidence of antitumor activity. Extension cohorts at DLs A5 and B5 are ongoing to confirm the recommended doses. Dose levels (DL) Arm A: Cis (mg/m2)/n of pts Arm B: Ca (AUC)/n of pts V (mg) A1/B1 60/3 4/3 100 A2/B2 75/3 5/3 100 A3/B3 75/3 5/3 200 A4/B4 75/3 5/6 300 A5/B5 100/6 6/3 300
Abstract 2806: Whole Heart Coronary Magnetic Resonance Angiography Using 32-Channel Cardiac Coils and High Parallel Imaging Factor
Authors: Motonori Nagata, Hajime Sakuma, Nanaka Ishida, Hiroshi Nakajima, Masaki Ishida, Masatoshi Miyahara, Shingo Kato, Mashio Nakamura, Masaaki Ito, Kan Takeda
Journal: Circulation (2008)

PURPOSE Coronary MRA provides noninvasive detection of coronary artery disease (CAD) without administration of contrast medium or exposing the patient to radiation. However, use of coronary MRA in excluding patients with CAD has been limited due to lengthy imaging time. The purpose of this study was to reduce acquisition time of coronary MRA by using 32 channel cardiac coils and high parallel imaging factor, and to evaluate diagnostic performance of this method in detecting significant CAD. METHOD AND MATERIALS Sixty-two patients with suspected CAD were studied. Free-breathing coronary MRA encompassing the entire heart was acquired by using 32-channel coils and SENSE factor of 4. After monitoring motion of the coronary artery on cine MRI, MR angiograms were acquired during diastole in 46 patients (acquisition window 82±57ms) and during systole in 16 patients (50±19ms). Coronary MRA images were interpreted by 2 observers by employing a sliding SLAB MIP method. All patients underwent X-ray coronary angiography within 4 weeks from MRA, and significant CAD was defined as a luminal diameter reduction of 50% or more by QCA. All lesions with a reference diameter of 2mm or more on X-ray angiography were included when determining the accuracy of coronary MRA. RESULTS Acquisition of MRA was completed in all 62 patients, with the averaged imaging time of 6.1±2.6min. High SENSE factor achieved by 32-channel coils resulted in substantial reduction of imaging time by factor of &gt;2, with the image quality score (4.6±0.2) at least equivalent to that by conventional 5-channel coils and SENSE factor of 2 (4.5±0.2). Significant CAD was observed on X-ray coronary angiography in 39 patients. MRA detected 33(85%) of 39 patients having CAD, with high specificity of 96%(22/23). All 16 patients with double- or triple-vessel diseases were detected by MRA. On a vessel based analysis, Whole-heart coronary MRA demonstrated sensitivity of 83%(49/59), specificity of 94%(119/127) and NPV of 92%(119/129). CONCLUSION Whole-heart coronary MRA with 1.5T MR imager and 32-chennel coils permits noninvasive detection of CAD with substantially reduced imaging time and high study success rate. High NPV (&gt;90%) indicated the value of this approach in ruling out significant CAD.
Putting semantics back into the semantic representation of living things
Authors: Deborah Zaitchik, Gregg E. A. Solomon
Journal: Behavioral and Brain Sciences (2001)

The authors' model reduces the literature on conceptual representation to a single node: “encyclopedic knowledge.” The structure of conceptual knowledge is not so trivial. By ignoring the phenomena central to reasoning about living things, the authors base their dismissal of semantic systems on inadequate descriptive ground. A better descriptive account is available in the conceptual development literature. Neuropsychologists could import the insights and tasks from cognitive development to improve their studies.