tbuckley/cabot-search huggingface dataset:
Clinician-reported Gloucester Comfort Scale scores underestimate patient discomfort and pain during colonoscopy: insights from comparison with a patient-reported experience measure
Authors: Querijn N.E. van Bokhorst, Charmayne V. Geerlings, Manon van der Vlugt, Karlijn J. Nass, Jos W. Borkent, Laura Jane Neilson, Paul Fockens, Colin Rees, Evelien Dekker
Journal: Endoscopy (2025)

Background Patient experience is a fundamental element of colonoscopy. The Gloucester Comfort Scale (GCS) is used by clinicians to report patient comfort. However, insights regarding the extent to which clinician-reported GCS scores represent the patient's experience are lacking. We assessed the level of agreement between clinician-reported GCS scores and patient-reported discomfort and pain. Methods Consecutive patients undergoing colonoscopy at two Dutch endoscopy clinics were included. Patient comfort during colonoscopy was reported using the GCS (1-5 scale). Patients’ colonoscopy experience was assessed using the Newcastle ENDOPREM, a validated endoscopy patient-reported experience measure (PREM). Patients reported both discomfort and pain levels experienced during colonoscopy on a 1-5 scale. Levels of agreement were assessed using Cohen's kappa statistic. Results For 243 included patients, the GCS score was higher than the discomfort score in 52 (21%) patients, and lower in 72 (30%). GCS score was higher than the pain score in 39 (16%) patients, and lower in 71 (29%). Moderate to severe discomfort and pain (scores &gt;3) were reported by 53 (22%) patients for discomfort and 60 (25%) patients for pain. For these patients, the GCS underestimated discomfort and pain levels in almost all cases (discomfort: 49/53 [92%], pain: 54/60 [90%]). The levels of agreement between GCS scores and discomfort and pain scores were minimal (Cohen’s κ: 0.34) and weak (Cohen’s κ: 0.47), respectively. Conclusions Clinician-reported GCS scores frequently underestimate the level of discomfort and pain as reported by patients. For accurate monitoring of patients’ colonoscopy experience, the use of PREMs should be considered.
Maternal views on RSV vaccination during the first season of implementation in England and Scotland
Authors: Thomas C Williams, Robin Marlow, Steve Cunningham, Simon B Drysdale, Helen Groves, Dalia Iskander, Xinxue Liu, Mark D Lyttle, Chengetai D Mpamhanga, Shaun O'Hagan, Thomas Waterfield, Damian Roland
Journal: The Lancet Infectious Diseases (2025)
The hospital and mortality burden of COVID-19 compared with influenza in Denmark: a national observational cohort study, 2022–24
Authors: Peter Bager, Ingrid Bech Svalgaard, Frederikke Kristensen Lomholt, Hanne-Dorthe Emborg, Lasse Engbo Christiansen, Bolette Soborg, Anders Hviid, Lasse S Vestergaard
Journal: The Lancet Infectious Diseases (2025)
Epidemiological and clinical features of mpox during the clade Ib outbreak in South Kivu, Democratic Republic of the Congo: a prospective cohort study
Authors: Isabel Brosius, Emmanuel Hasivirwe Vakaniaki, Guy Mukari, Papy Munganga, Jean Claude Tshomba, Elise De Vos, Eugene Bangwen, Yves Mujula, Achilleas Tsoumanis, Christophe Van Dijck, Aimé Alengo, Léandre Mutimbwa-Mambo, Franklin Mweshi Kumbana, Jenestin Babingwa Munga, Divin Mazambi Mambo, James Wakilongo Zangilwa, Steeven Bilembo Kitwanda, Sarah Houben, Nicole A Hoff, Jean-Claude Makangara-Cigolo, Eddy Kinganda-Lusamaki, Martine Peeters, Anne W Rimoin, Jason Kindrachuk, Nicola Low, Patrick D M C Katoto, Espoir Bwenge Malembaka, John H Amuasi, Olivier Tshiani-Mbaya, Dally Muamba Kambaji, Richard Kojan, Cris Kacita, Daniel Mukadi-Bamuleka, Steve Ahuka-Mundeke, Koen Vercauteren, Tony Wawina-Bokalanga, Jean-Jacques Muyembe-Tamfum, Sabin Sabiti Nundu, Laurens Liesenborghs, Placide Mbala-Kingebeni
Journal: The Lancet (2025)
Predicting benefit from adjuvant therapy with corticosteroids in community-acquired pneumonia: a data-driven analysis of randomised trials
Authors: Jim M Smit, Philip A Van Der Zee, Sara C M Stoof, Michel E Van Genderen, Dominic Snijders, Wim G Boersma, Paola Confalonieri, Francesco Salton, Marco Confalonieri, Mei-Chiung Shih, Gianfranco U Meduri, Pierre-François Dequin, Amélie Le Gouge, Melanie Lloyd, Harin Karunajeewa, Grzegorz Bartminski, Silvia Fernández-Serrano, Guillermo Suárez-Cuartín, David van Klaveren, Matthias Briel, Christof M Schönenberger, Ewout W Steyerberg, Diederik A M P J Gommers, Hannelore I Bax, Wilem Jan W Bos, Ewoudt M W van de Garde, Esther Wittermans, Jan C Grutters, Claudine A Blum, Mirjam Christ-Crain, Antoni Torres, Ana Motos, Marcel J T Reinders, Jasper Van Bommel, Jesse H Krijthe, Henrik Endeman
Journal: The Lancet Respiratory Medicine (2025)
Emergence and spread of the SARS-CoV-2 omicron (BA.1) variant across Africa: an observational study
Authors: Carlo Fischer, Tongai Gibson Maponga, Anges Yadouleton, Nuro Abílio, Emmanuel Aboce, Praise Adewumi, Pedro Afonso, Jewelna Akorli, Soa Fy Andriamandimby, Latifa Anga, Yvonne Ashong, Mohamed Amine Beloufa, Aicha Bensalem, Richard Birtles, Anicet Luc Magloire Boumba, Freddie Bwanga, Mike Chaponda, Paradzai Chibukira, R Matthew Chico, Justin Chileshe, Wonderful Choga, Gershom Chongwe, Assana Cissé, Fatoumata Cissé, Umberto D'Alessandro, Xavier de Lamballerie, Joana F M de Morais, Fawzi Derrar, Ndongo Dia, Youssouf Diarra, Lassina Doumbia, Christian Drosten, Philippe Dussart, Richard Echodu, Abdelmajid Eloualid, Ousmane Faye, Torsten Feldt, Anna Frühauf, Simani Gaseitsiwe, Afiwa Halatoko, Etuhole Iipumbu, Pauliana-Vanessa Ilouga, Nalia Ismael, Ronan Jambou, Sheikh Jarju, Antje Kamprad, Ben Katowa, John Kayiwa, Leonard King'wara, Ousmane Koita, Vincent Lacoste, Adamou Lagare, Olfert Landt, Sonia Etenna Lekana-Douki, Jean-Bernard Lekana-Douki, Hugues Loemba, Tom Luedde, Julius Lutwama, Santou Mamadou, Issaka Maman, Brendon Manyisa, Pedro A Martinez, Japhet Matoba, Lusia Mhuulu, Andrés Moreira-Soto, Sikhulile Moyo, Judy Mwangi, Nadine N'dilimabaka, Charity Angella Nassuna, Mamadou Ousmane Ndiath, Emmanuel Nepolo, Richard Njouom, Jalal Nourlil, Steven Ger Nyanjom, Eddy Okoth Odari, Alfred Okeng, Jean Bienvenue Ouoba, Michael Owusu, Irene Owusu Donkor, Karabo Kristen Phadu, Richard Odame Phillips, Wolfgang Preiser, Pierre Roques, Vurayai Ruhanya, Fortune Salah, Sourakatou Salifou, Amadou Alpha Sall, Augustina Angelina Sylverken, Paul Alain Tagnouokam-Ngoupo, Zekiba Tarnagda, Francis Olivier Tchikaya, Noël Tordo, Tafese Beyene Tufa, Jan Felix Drexler
Journal: The Lancet Global Health (2025)
Automated oxygen control for preterm infants receiving continuous positive airway pressure in southwest Nigeria: an open-label, randomised, crossover trial
Authors: Rami Subhi, Lachlann McLeod, Adejumoke Idowu Ayede, Iyabode Olabisi Dedeke, Quadri Risikat, Alao Ridwan Akanbi, Adeola Baliqis Fasasi, Ayobami A Bakare, Oluwatosin Helen Adeniyi, Olugbenga Akinrinoye, Olanrewaju Adeigbe, George F Dargaville, Patrick Walker, Anneke C Grobler, Olufunke Mosebolatan, Shiraz Badurdeen, Timothy J Gale, Adegoke G Falade, Peter A Dargaville, Hamish R Graham
Journal: The Lancet Global Health (2025)
Associations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study
Authors: Megan Bailey, Graeme Fairchild, Gemma Hammerton, Andreas Bauer, Marina X Carpena, Joseph Murray, Ina S Santos, Aluísio J D Barros, Luciana Tovo-Rodrigues, Andrea Danese, Sarah L Halligan, Alicia Matijasevich
Journal: The Lancet Global Health (2025)
Prevalence, aetiology, and hospital outcomes of paediatric acute critical illness in resource-constrained settings (Global PARITY): a multicentre, international, point prevalence and prospective cohort study
Authors: Teresa B Kortz, Adrian Holloway, Asya Agulnik, David He, Stephanie Gordon Rivera, Qalab Abbas, John Adabie Appiah, Anita V Arias, Jonah Attebery, Jhon Camacho-Cruz, Paula Caporal, Karla Emilia de Sa Rodrigues, Ericka Fink, Niranjan Kissoon, Jan Hau Lee, Eliana López-Barón, Srinivas Murthy, Fiona Muttalib, Katie Nielsen, Kenneth Remy, Firas Sakaan, Amelie von Saint Andre-von Arnim, Adriana Teixeira Rodrigues, William Blackwelder, Matthew O Wiens, Adnan Bhutta
Journal: The Lancet Global Health (2025)
The prevalence of hypoxaemia in paediatric and adult patients in health-care facilities in low-income and middle-income countries: a systematic review and meta-analysis
Authors: Hamish R Graham, Esrat Jahan, Rami Subhi, Farhia Azrin, Jaclyn R Maher, Jasmine L Miller, Ahmed Ehsanur Rahman, Felix Lam
Journal: The Lancet Global Health (2025)
Artificial intelligence-guided detection of under-recognised cardiomyopathies on point-of-care cardiac ultrasonography: a multicentre study
Authors: Evangelos K Oikonomou, Akhil Vaid, Gregory Holste, Andreas Coppi, Robert L McNamara, Cristiana Baloescu, Harlan M Krumholz, Zhangyang Wang, Donald J Apakama, Girish N Nadkarni, Rohan Khera
Journal: The Lancet Digital Health (2025)
24-week, all-oral regimens for pulmonary rifampicin-resistant tuberculosis in TB-PRACTECAL trial sites: an economic evaluation
Authors: Sedona Sweeney, Yoko V Laurence, Catherine Berry, Maninder Pal Singh, Matthew Dodd, Katherine Fielding, Emil Kazounis, Ronelle Moodliar, Varvara Solodovnikova, Zinaida Tigay, Irina Liverko, Nargiza Parpieva, Ilhomjon Butabekov, Ruzilya Usmanova, Mohammed Rassool, Ilaria Motta, George Mokua Nyangweso, Pascal Jolivet, Tleubergen Abdrasuliev, Soe Moe, Pei Sun Aw, Nazgul Samieva, Bern-Thomas Nyang'wa
Journal: The Lancet Global Health (2025)
Prevalence and demographics of 331 rare diseases and associated COVID-19-related mortality among 58 million individuals: a nationwide retrospective observational study
Authors: Johan H Thygesen, Huayu Zhang, Hanane Issa, Jinge Wu, Tuankasfee Hama, Ana-Caterina Phiho-Gomes, Tudor Groza, Sara Khalid, Thomas R Lumbers, Mevhibe Hocaoglu, Kamlesh Khunti, Rouven Priedon, Amitava Banerjee, Nikolas Pontikos, Chris Tomlinson, Ana Torralbo, Paul Taylor, Cathie Sudlow, Spiros Denaxas, Harry Hemingway, Honghan Wu
Journal: The Lancet Digital Health (2025)
Diagnoses supported by a computerised diagnostic decision support system versus conventional diagnoses in emergency patients (DDX-BRO): a multicentre, multiple-period, double-blind, cluster-randomised, crossover superiority trial
Authors: Wolf E Hautz, Thimo Marcin, Stefanie C Hautz, Stefan K Schauber, Gert Krummrey, Martin Müller, Thomas C Sauter, Cornelia Lambrigger, David Schwappach, Mathieu Nendaz, Gregor Lindner, Simon Bosbach, Ines Griesshammer, Philipp Schönberg, Emanuel Plüss, Valerie Romann, Svenja Ravioli, Nadine Werthmüller, Fabian Kölbener, Aristomenis K Exadaktylos, Hardeep Singh, Laura Zwaan
Journal: The Lancet Digital Health (2025)
Causes of HIV-related CNS infection in Cameroon, Malawi, and Tanzania: epidemiological findings from the DREAMM HIV-related CNS implementation study
Authors: Cecilia Kanyama, Charles Kouanfack, Saulos Nyirenda, Sayoki Mfinanga, Sokoine Lesikari Kivuyo, Emma Beaumont, Aude Sturny-Leclère, Sam Phiri, Jonathon Ngoma, Meshack Shimwela, Daniel Nkungu, Lauriane Nomene Fomete, Rehema Simbauranga, Chimwemwe Chawinga, Nicaine Ngakam, Tom Heller, Sandrine Sa'a Lontsi, Rebecca Gathercole, Elnara Aghakishiyeva, Radha Rajasingham, Mina C Hosseinipour, John Bradley, Shabbar Jaffar, Olivier Lortholary, Thomas Harrison, Síle F Molloy, Timothée Boyer-Chammard, Angela Loyse
Journal: The Lancet Global Health (2025)
Social and health disparities associated with healthy brain ageing in Brazil and in other Latin American countries
Authors: Lucas U Da Ros, Wyllians Vendramini Borelli, Cristiano Schaffer Aguzzoli, Marco Antônio De Bastiani, Lucas Porcello Schilling, Hernando Santamaria-Garcia, Tharick A Pascoal, Pedro Rosa-Neto, Diogo O Souza, Jaderson Costa da Costa, Agustin Ibañez, Claudia Kimie Suemoto, Eduardo R Zimmer
Journal: The Lancet Global Health (2025)
Variability and social patterning of cancer mortality in 343 Latin American cities: an ecological study
Authors: Tania Alfaro, Kevin Martinez-Folgar, Dalia Stern, Maria A Wilches-Mogollon, María Pía Muñoz, Harrison Quick, Marcio Alazraqui, Manuel Ramirez-Zea, J Jaime Miranda, Mariana Lazo, Waleska Teixeira Caiaffa, Ana V Diez Roux, Usama Bilal
Journal: The Lancet Global Health (2025)
Durability of immunogenicity at 5 years after a single dose of human papillomavirus vaccine compared with two doses in Tanzanian girls aged 9–14 years: results of the long-term extension of the DoRIS randomised trial
Authors: Deborah Watson-Jones, John Changalucha, Caroline Maxwell, Hilary Whitworth, Paul Mutani, Troy J Kemp, Beatrice Kamala, Jackton Indangasi, George Constantine, Ramadhan Hashim, David Mwanzalima, Rebecca Wiggins, Devis Mmbando, Nicholas Connor, Miquel A Pavon, Brett Lowe, Saidi Kapiga, Philippe Mayaud, Silvia de Sanjosé, Joakim Dillner, Richard J Hayes, Charles J Lacey, Ligia Pinto, Kathy Baisley
Journal: The Lancet Global Health (2025)
The effects of prenatal multiple micronutrient supplementation and small-quantity lipid-based nutrient supplementation on small vulnerable newborn types in low-income and middle-income countries: a meta-analysis of individual participant data
Authors: Dongqing Wang, Enju Liu, Nandita Perumal, Uttara Partap, Ilana R Cliffer, Janaína Calu Costa, Molin Wang, Wafaie W Fawzi
Journal: The Lancet Global Health (2025)
Effectiveness of 2023 southern hemisphere influenza vaccines against severe influenza-associated illness: pooled estimates from eight countries using the test-negative design
Authors: Radhika Gharpure, Annette K Regan, Francisco Nogareda, Allen C Cheng, Christopher C Blyth, Siobhan St George, Q Sue Huang, Tim Wood, Andrew Anglemyer, Kriengkrai Prasert, Prabda Praphasiri, William W Davis, Chakrarat Pittayawonganon, Regina Ercole, Analia Iturra, Walquiria Aparecida Ferreira de Almeida, Francisco José de Paula Júnior, Marcela Avendaño Vigueras, Maria Fernanda Olivares Barraza, Chavely Domínguez, Elena Penayo, Natalia Goñi, Daiana Tritten, Paula Couto, Daniel Salas, Ashley L Fowlkes, Lindsey M Duca, Eduardo Azziz-Baumgartner, Sheena G Sullivan
Journal: The Lancet Global Health (2025)
Early detection and a treatment bundle strategy for postpartum haemorrhage: a mixed-methods process evaluation
Authors: Meghan A Bohren, Suellen Miller, Kristie-Marie Mammoliti, Hadiza Galadanci, Sue Fawcus, Neil Moran, G Justus Hofmeyr, Zahida Qureshi, Fadhlun Alwy Al-Beity, Gillian Forbes, Shahinoor Akter, Alfred Osoti, George Gwako, Thiago Melo Santos, Cherrie Evans, Aminu Ado Wakili, Maisaratu Bakari, Idris Usman Takai, Mohammad Umar, Mandisa Singata-Madliki, Elani Muller, Sibongile Mandondo, Jenipher Okore, Akwinata Banda, Masumbuko Sambusa, Kulandaipalayam N Sindhu, Leanne Beeson, Christina Louise Easter, Adam Devall, A Metin Gülmezoglu, Fernando Althabe, Olufemi T Oladapo, Ioannis Gallos, Arri Coomarasamy, Fabiana Lorencatto
Journal: The Lancet Global Health (2025)
Epidemiology of menstrual-related absenteeism in 44 low-income and middle-income countries: a cross-sectional analysis of Multiple Indicator Cluster Surveys
Authors: Miranda Starr, Rebecca Harding, Ricardo Ataíde, Naomi Von Dinklage, Sheela S Sinharoy, Yasmin Jayasinghe, Lucinda Manda-Taylor, Jane Fisher, Sabine Braat, Sant-Rayn Pasricha
Journal: The Lancet Global Health (2025)
Accumulation of altered serum bile acids predicts liver injury after portoenterostomy in biliary atresia
Authors: Iiris Nyholm, Maria Hukkinen, Jouko Lohi, Nelli Sjöblom, Aino Mutka, Annika Mutanen, Satu Ruuska, Mikko Neuvonen, Satu Hänninen, Olli Carpén, Johanna Arola, Timo Jahnukainen, Mikko Niemi, Markku Heikinheimo, Mikko P Pakarinen
Journal: Journal of Hepatology (2025)

Little is known on the mechanism of liver injury mediated by bile acids following Kasai portoenterostomy (KPE) in biliary atresia (BA). We sought to quantify individual serum bile acids, 7-alpha-hydroxy-4-cholesten-3-one (C4), and fibroblast growth factor 19 (FGF19) after KPE and to evaluate their prognostic utility and transcriptomic regulation. Serum (n=244) and liver specimens (n=105) prospectively obtained from BA patients (n=54) after KPE were included. Bile acids were analyzed using mass spectrometry, gene expression with quantitative PCR, and histopathology using a neural network model. Following KPE, serum bile acids correlated positively with biochemical liver injury, pediatric end-stage liver disease score, liver stiffness, histological ductular reaction, and liver fibrosis. Bile acids were higher among patients who developed portal hypertension (79.6 vs. 11.9 μmol/l, p<0.0001), esophageal varices (91.6 vs. 16.2 μmol/l, p<0.0001), or required liver transplantation (LT, 115.3 vs. 22.0 μmol/l, p<0.0001) during follow up; bile acids predicted these outcomes in time-dependent regression models. Accumulation of conjugated bile acids, cholic acid, and taurine conjugates predicted LT risk while associating with histological liver injury. Serum C4 (0.04 vs. 0.00 μmol/l, p=0.04) and liver CYP7A1 were higher in native liver survivors than in LT patients (fold-change 16.9 vs. 7.0, p=0.02). Primary bile acids correlated negatively with C4 (R=-0.38, p<0.001) and CYP7A1 (R=-0.49, p=0.01). Unlike in native liver survivors (R=-0.19, p=0.66), serum FGF19 correlated with liver FGF19 (R=0.59, p=0.04) without an inverse association with serum primary bile acids in LT patients (R=0.26, p=0.08). Accumulation and altered composition of serum bile acids predicted progressive liver disease and poorer transplant-free survival following KPE. Poor prognosis was associated with low bile acid synthesis and aberrantly increased liver FGF19. Biliary atresia (BA), a fibro-obliterating biliary disease of infants, remains the most common indication for pediatric liver transplantation caused by rapid progression of liver injury. To identify predictive biomarkers of disease progression and to elucidate the pathophysiology of BA liver injury, we profiled serum bile acids and studied their liver metabolism after Kasai portoenterostomy. Accumulation and altered composition of circulating bile acids predicted progression of liver disease and need for liver transplantation. Patients with poor prognosis showed low bile acid synthesis and abnormal liver expression of fibroblast growth factor 19.
DSAM: A deep learning framework for analyzing temporal and spatial dynamics in brain networks
Authors: Bishal Thapaliya, Robyn Miller, Jiayu Chen, Yu Ping Wang, Esra Akbas, Ram Sapkota, Bhaskar Ray, Pranav Suresh, Santosh Ghimire, Vince D Calhoun, Jingyu Liu
Journal: Medical Image Analysis (2025)

Resting-state functional magnetic resonance imaging (rs-fMRI) is a noninvasive technique pivotal for understanding human neural mechanisms of intricate cognitive processes. Most rs-fMRI studies compute a single static functional connectivity matrix across brain regions of interest, or dynamic functional connectivity matrices with a sliding window approach. These approaches are at risk of oversimplifying brain dynamics and lack proper consideration of the goal at hand. While deep learning has gained substantial popularity for modeling complex relational data, its application to uncovering the spatiotemporal dynamics of the brain is still limited. In this study we propose a novel interpretable deep learning framework that learns goal-specific functional connectivity matrix directly from time series and employs a specialized graph neural network for the final classification. Our model, DSAM, leverages temporal causal convolutional networks to capture the temporal dynamics in both low- and high-level feature representations, a temporal attention unit to identify important time points, a self-attention unit to construct the goal-specific connectivity matrix, and a novel variant of graph neural network to capture the spatial dynamics for downstream classification. To validate our approach, we conducted experiments on the Human Connectome Project dataset with 1075 samples to build and interpret the model for the classification of sex group, and the Adolescent Brain Cognitive Development Dataset with 8520 samples for independent testing. Compared our proposed framework with other state-of-art models, results suggested this novel approach goes beyond the assumption of a fixed connectivity matrix, and provides evidence of goal-specific brain connectivity patterns, which opens up potential to gain deeper insights into how the human brain adapts its functional connectivity specific to the task at hand. Our implementation can be found on https://github.com/bishalth01/DSAM.
Evolving Epidemiology of Mpox in Africa in 2024
Authors: Nicaise Ndembi, Morenike O Folayan, Allan Komakech, Kyeng Mercy, Sofonias Tessema, Placide Mbala-Kingebeni, Christian Ngandu, Ngashi Ngongo, Jean Kaseya, Salim S Abdool Karim
Journal: New England Journal of Medicine (2025)

For decades after the identification of mpox in humans in the Democratic Republic of Congo (DRC) in 1970, the disease was largely confined to the rural areas of Central and West Africa and thus did not garner broad attention. On August 13, 2024, mpox was declared a Public Health Emergency of Continental Security (PHECS) by the Africa Centers for Disease Control and Prevention (Africa CDC), a notice that was followed the next day by a declaration of a Public Health Emergency of International Concern (PHEIC) by the World Health Organization. In this study we analyzed all mpox cases and deaths, based on clinical or laboratory diagnosis, that were reported to the Africa CDC from January 1, 2022, to October 30, 2024, to identify temporal variations, geographic distributions, and epidemiologic trends. From January 1, 2022, to August 18, 2024, a total of 45,652 mpox cases were clinically diagnosed and laboratory-confirmed in 12 African countries. These cases resulted in 1492 deaths (case fatality rate, 3.3%). From 2022 to 2024, weekly laboratory-confirmed mpox cases increased by a factor of 2.8 (from 176 to 489 cases), whereas all weekly reported cases (including those with a clinical diagnosis) increased by a factor of 4.3 (from 669 to 2900 cases). The DRC, which had reported approximately 88% of mpox cases in Africa in 2024, had 19,513 cases before the emergency declaration, with a case fatality rate of 3.1% - a weekly average of 591 cases as compared with 281 in 2023. In 2024, six African countries reported their first imported mpox infections, with Burundi also reporting local transmission. The high mpox disease burden in Africa, especially in the DRC - with a rising number of cases, high case fatality rate, and high degree of spread to other previously mpox-free African countries - is cause for increased international concern. Case detection, contact tracing, public health measures, and affordable vaccines are needed to implement interventions in the DRC to reduce the risk of global spread of the virus.
Tirzepatide for Congenital Generalized Lipodystrophy
Authors: Svetlana Ten, Amrit Bhangoo, Christoph Buettner
Journal: New England Journal of Medicine (2025)

Two patients with congenital generalized lipodystrophy type 1 due to a variant in AGPAT2 (c.589-2A→G) who had been receiving insulin and metreleptin were switched to tirzepatide and were successfully weaned off other therapy.