tbuckley/cabot-search huggingface dataset:
Abstract 10576: Markers of Periodontal Disease Predict Myocardial Infarction, Stroke and Heart Failure Differently in a Cohort of 7999 Subjects
Authors: Anders Holmlund, Lars Lind
Journal: Circulation (2011)

Objective: Oral health has been associated with an increased risk for different cardiovascular disorders. So far, however, no study has investigated oral health in relation to the three most common...
Abstract 15686: Renal Collecting Duct Epithelial Cells Regulate Inflammation in Chronic Kidney Disease and Cardiorenal Interactions
Authors: Katsuhito Fujiu, Ichiro Manabe, Ryozo Nagai
Journal: Circulation (2011)

Chronic kidney disease (CKD) is a significant risk factor for cardiovascular disease. However, the molecular mechanisms underlying its development and cardiorenal interactions are insufficiently un...
Alexithymia and the Split Brain
Authors: Ten Houten, D.O. Walter, K.D. Hoppe, J.E. Bogen
Journal: Psychotherapy and Psychosomatics (1987)

Electroencephalographic (EEG) recordings were obtained while 6 completely commissurotomized patients, 2 partially commissurotomized patients, and 8 precision-matched normal control subjects watched 4 times a film symbolically depicting death. Our hypothesis was that alexithymia – a diminished capability to verbally express moods, symbols, and feelings – would be greater for patients because loss of cerebral commissures reduces interhemispheric communication, separating right-hemisphere-dependent affective understanding and left-hemisphere-dependent verbalization. Path and covariance structure analyses confirmed that callosotomy decreased alpha-band EEG coherences (after adjustment for mean intrahemispheric coherence) between pairs of scalp electrode channels placed homologously over frontal, parietal, and temporal lobes of the brain. This result occurred both for an index of interhemispheric coherence and for a latent variable indicated by the 3 adjusted coherences. Reduced levels of interhemispheric coherence in turn increased alexithymia, for an overall index and for a latent variable indicated by lexical-level content-analytic measures of verbal responses to the filmic stimulus.
Mental Illness and Pregnancy
Authors: Gisèle Apter, Valérie Garez, François Medjkane
Journal: BMJ (1964)

Pregnancy was once thought a period of bliss devoid of mental illness. We now know this is not so. It is well documented that pregnancy and the peripartum are not only a time when preexisting mental illness will persist but that it is also a high-risk period for renewed episodes of mental illness, whether de novo or relapse. In this paper, we will describe the three main axis of management of maternal mental illness during the peripartum: maternal psychiatric illness, fetal, neonatal and infant development and future mother-infant relationship. We will give an overview of how to organize care for mothers with schizophrenia and bipolar disorder. Good practice management of psychotropic medication during this period will be described. Finally the importance of networking and multidisciplinary management of these situations will be underlined.
Suitability of a cocktail of CD3 and CD7 ricin A-immunotoxins for in vivo treatment of acute graft-versus-host-disease
Authors: Y.V.J.M. van Oosterhout, L. van Emst, A. Schattenberg, S. Evers, C. Mandigers, W.J.M. Tax, H. Spits, T. de Witte, F.W.M.B. Preijers
Journal: Blood (1997)
The concept of drug automatism
Authors: M I Good
Journal: American Journal of Psychiatry (1976)

The drug-automatism hypothesis implies a medication-induced absence of intentionality for self-poisoning and a relative amnesia for serial or single overdosage. Controversy stems from problems encountered in the formulation and verfication of the hypothesis. The author reviews the literature, presents a case associated with a proprietary sleeping preparation, and discusses psychopharmacological and psychophysiological elements in the mechanism of drug automatism and its differential diagnosis.
Abstract 251: Endogenous Endocrine Function of Cardiac-derived Nitric Oxide Yields Distant Organ Protection Against Ischemic Injury
Authors: John W Elrod, Nathan S Bryan, John W Calvert, Susheel Gundewar, David J Lefer
Journal: Circulation (2007)

Background : eNOS-derived nitric oxide (NO) has long been considered a paracrine signaling molecule only capable of affecting nearby cells due to its short half-life in blood (&lt;2ms). We have recently shown that nitrite, previously thought to be an inert oxidation product of NO, is an important storage form converted to NO under hypoxic conditions via reductase activity. Currently, no studies have revealed endogenously generated NO to possess a clearly defined endocrine function, we therefore evaluated whether generation of NO in the heart could modulate remote physiological actions. Methods: Mice with cardiac-specific (αMHC promoter) eNOS overexpression (CS-eNOS-Tg) and WT littermates were analyzed for NO metabolites in the heart, plasma, and liver (NO 2 − /NO 3 − - ion chromatography; nitroso/NO-heme - gas phase chemiluminescence). WT and CS-eNOS-Tg mice were subjected to 60 min hepatic ischemia and following 5 hr reperfusion (IR) serum ALT and AST were analyzed. Results: Overexpression of eNOS restricted to the heart resulted in a significant increase in nitrite in the heart (2.2 fold), plasma (3.2 fold) and liver (6.5 fold). CS-eNOS-Tg displayed a significant reduction in hepatic IR injury (4.3 fold reduction in ALT and a 3.5 fold reduction in AST). Conclusions: This represents the first report demonstrating that eNOS-derived NO is transported in the blood and stored in remote organs. Importantly, increases in nitrite levels resulted in protection against IR injury. These findings suggest NO possesses endocrine function via transport of nitrite in the blood to distant organs and that transported nitrite exhibits physiological activity.
Androgen Receptor Gene Amplification in a Recurrent Prostate Cancer after Monotherapy with the Nonsteroidal Potent Antiandrogen Casodex (Bicalutamide) with a Subsequent Favorable Response to Maximal Androgen Blockade
Authors: C. Palmberg, P. Koivisto, E. Hyylinen, J. Isola, T. Visakorpi, O.-P. Kallioniemi, T. Tammela
Journal: European Urology (1997)
Attention deficit hyperactivity disorder and comorbid disorders: issues of overlapping symptoms
Authors: S Milberger, J Biederman, S V Faraone, J Murphy, M T Tsuang
Journal: American Journal of Psychiatry (1995)

Since some symptoms are shared by both attention deficit hyperactivity disorder (ADHD) and comorbid psychiatric conditions, it is possible that a diagnosis of ADHD is an artifact of the overlapping symptoms. This article focuses on the assessment of the influence of overlapping symptoms on the diagnosis of ADHD.Three groups of subjects were studied: a group of clinically referred children and adolescents, a group of nonreferred adults who were the parents of these children and adolescents, and a group of clinically referred adults with ADHD. The authors assessed the extent of symptom overlap between ADHD and the disorders that frequently co-occur with ADHD; major depression, bipolar disorder, and generalized anxiety disorder. To determine the degree to which this symptom overlap influences these diagnoses, each individual was rediagnosed on the basis of two different techniques that corrected for the overlapping symptoms, a subtraction method and a proportion method.The majority of subjects who had both ADHD and a comorbid psychiatric disorder maintained their diagnosis of ADHD when the overlapping symptoms were subtracted. Moreover, when overlapping ADHD symptoms were subtracted, on average, 79% maintained their diagnosis of major depression, 56% maintained their diagnosis of bipolar disorder, and 75% maintained their diagnosis of generalized anxiety disorder.These findings show that ADHD is not an artifact of symptoms shared with other psychiatric disorders and that the comorbid conditions themselves are not an artifact of overlapping ADHD symptoms.
Electrophysiological, Electroanatomical, and Structural Remodeling of the Atria as Consequences of Sustained Obesity
Authors: Rajiv Mahajan, Dennis H. Lau, Anthony G. Brooks, Nicholas J. Shipp, Jim Manavis, John P.M. Wood, John W. Finnie, Chrishan S. Samuel, Simon G. Royce, Darragh J. Twomey, Shivshanker Thanigaimani, Jonathan M. Kalman, Prashanthan Sanders
Journal: Journal of the American College of Cardiology (2015)
Physical and mental health correlates of pregnancy following breast cancer
Authors: J. Gorman, S. Roesch, J. Pierce, B. Parker, L. Madlensky, N. Saquib, V. Newman
Journal: Journal of Clinical Oncology (2009)

e20552 Background: The possibility and safety of pregnancy after breast cancer is an important issue for many younger breast cancer survivors and their health care providers. Current research does not indicate that survival is negatively affected by pregnancy. However, the “healthy mother bias”, suggesting that survivors who go on to become pregnant are a self-selected healthier group based on their prognosis, has led to cautious interpretation of these findings. No studies have systematically evaluated the potential for this bias. Methods: This nested case-control study includes 81 participants, age 40 or younger at diagnosis, from the Women's Healthy Eating and Living Study (WHEL) (N=3,088). Our sample includes 27 cases who went on to have a child after breast cancer and 54 controls, matched on age and stage at diagnosis, who did not. We used hierarchical linear modeling to accommodate longitudinal data with individuals nested within matched sets (cases and controls). The primary aim was to evaluate the association between summary scores of health and successful pregnancy after breast cancer. The outcome variables, physical health summary score (PHSS) and mental health summary score (MHSS), were taken from the RAND 36 item health survey (SF-36). Covariates were added for adjustment and to improve model precision. Results: Controlling for other variables in the model, mean PHSS were not different among cases compared to controls (B=0.14, p=0.96) (n=152). MHSS were marginally higher among cases (B=6.40, p=0.08), as compared to controls (n=154). This difference is considered clinically significant. Conclusions: While based on a small sample size, this preliminary study did not find evidence of a healthy mother bias based on scores of physical health. However, mental health was marginally better among those who went on to have a child, indicating that the role of mental health should be evaluated in future research. No significant financial relationships to disclose.
Transfection with anti-p65 intrabody suppresses invasion, metastasis, and angiogenesis in glioma cells by blocking NF-κβ transcriptional activity
Authors: Liang Li, Christopher S. Gondi, Meena Gujrati, Dzung H. Dinh, William C. Olivero, Jasti S. Rao
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

245 

Growing evidence suggests that aberrant or constitutively activated NF-κβ regulates the expression of numerous genes involved in the proliferation, migration, angiogenesis and metastasis of human gliomas. As such, NF-κβ is a potential therapeutic target for the treatment of cancer. In order to prevent transcriptional activity of NF-κβ in the nuclei of glioma cells and to inhibit the bioactivity of its target cancer-related genes, a single-chain antibody against human p65 (RelA, subunit of NF-κβ ), which recognizes a C-terminal epitope in the region involved in the transactivation function of p65, was prepared with phage libraries display technique using a human single fold scFv libraries (Tomlinson I + J). In addition, we prepared a construct of anti-p65 intrabody (pFv/nu) by cloning anti-p65 scFv-encoding sequence into the pCMV/myc/nuc vector for the intracellular targeting of antibodies. p65 expression in human malignant glioma U251 and U87 cells transfected with pFv/nu was significantly decreased as determined by immunoblotting and flow cytometry assay. Our results from immunoblotting and electrophoretic mobility shift assay (EMSA) demonstrated that translocation ability into the nucleus and sequence-specific DNA binding activity of NF-κβ were blocked as compared with parental (U251 and U87) and control vector-transfected cells. Inhibition of NF-κβ transcriptional activity in the nucleus by intrabody transfection resulted in the downregulation of MMP-9, MMP-2, uPAR, uPA and VEGF, which play important roles in tumor invasion, metastasis, and angiogenesis. The significant inhibitory activities of MMP-9, MMP-2 and uPA were also detected using gelatin and fibrin zymography. Furthermore, the migration ability of glioma cells invading a matrigel-coated membrane was decreased in in vitro invasion assay after intrabody transfection. However, blocking NF-κβ activity by intrabody transfection did not induce NF-κβ-mediated apoptosis in U251 and U87 glioma cells as compared with the control vector pCMV/nu. In addition, intrabody expression in the nuclear compartment did not alter the cell proliferation ability of U251 and U87 cells. Our results suggest that blocking NF-κβ transcriptional activity via intrabody expression in the nuclei of human glioma cells contributes to the inhibition of invasion, metastasis and angiogenesis of human gliomas through downregulation of its target proteins including MMP-9, uPA and VEGF.
Abstract 481: Characteristics of Two Thrombotic Thrombocytopenic Purpura (TTP) Syndromes Associated with Ticlopidine and Clopidogrel: Results From the Surveillance, Epidemiology, and Risk Factors for Thrombotic Thrombocytopenic Purpura (SERF-TTP) Research Group
Authors: Benjamin Kim, Charles Davidson, Hau C Kwaan, Anaadriana Zakarija, Nicholas Bandarenko, Dilip K Pandey, Ravindra Sarode, June M McKoy, Amul D Tevar, John F Cursio, Thomas J Raife, Joseph E Kiss, Dennis W Raisch, J. E Sadler, Thomas L Ortel, X. L Zheng, Seiji Kato, Masanori Matsumoto, Masahito Uemura, Yoshihiro Fujimura, Charles L Bennett
Journal: Circulation (2006)

Background: Most idiopathic TTP cases have ADAMTS13 deficiency. We evaluated clinical and laboratory findings for patients with TTP caused by the thienopyridines, ticlopidine and clopidogrel, the m...
Role of mutant p53 mediated transactivation in oncogenesis and gain-of-function. NF-κB2 and chemoresistance
Authors: Mariano J. Scian, Michelle E. Anderson, Katherine R. Stagliano, Swati P. Deb, Sumitra Deb
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

3348 

Over-expression of mutant p53 is a common theme in tumors suggesting a selective pressure for p53 mutation in cancer development and progression. Here, we have investigated the role of mutant p53-mediated transactivation in gain-of-function. We have expressed mutant p53 in various cell types and tested for gain-of-function phenotypes. In tumorigenicity studies, non-tumorigenic p53-null murine 10(3) cells expressing p53-D281G were found to be tumorigenic in nude mice whereas cells stably transfected with vector alone or cells expressing transactivation deficient mutants were not. This re-enforced the notion that gain-of-function is dependent on mutant p53’s transactivation ability. Similarly, Saos-2 human osteosarcoma cells expressing a transactivation deficient mutant p53 generated fewer colonies in soft agar than those expressing the transactivating p53-D281G form. Furthermore, H1299 cells expressing p53 mutants (p53-R175H, -R273H or -D281G) showed decreased sensitivity to etoposide, a common chemotherapeutic agent; however, cells expressing the transactivation deficient mutant p53-D281G (L22Q/W23S) had significantly lower resistance to etoposide treatment. Growth curves of these cells followed a similar pattern. Gene expression profiling of cells expressing transcriptionally active mutant p53 proteins revealed a striking pattern that all three p53 mutants induced expression of approximately 100 genes involved in various aspects of cell growth. The genes identified included anti-apoptotic genes (API5, MCL-1 and NF-κB2), transcription factors (NF-κB2 and E2F-5), cell cycle related genes (ASNS, CDC25A, Cyclin B2 and MCM6), angiogenic genes (ANGPT1), oncogenic/transforming genes (EBAG9, ITGA6, API5, MCL-1, c-myc and C-SYN) and various others (NARS, POLD2 and RNA polII E). These results strongly suggest that tumor-derived mutant p53-mediated transactivation has a significant role in oncogenic development. Among the identified genes, NF-κB2 is prominent anti-apoptotic gene. Treatment of H1299 cells expressing mutant p53 with the NF-κB inhibitor sulfasalazine increased the sensitivity of the cells to etoposide. This and other data, suggest that the NF-kB pathway plays a role in chemoresistance.
Some Implications of Legalized Substitution of Prescribed Pharmaceuticals
Authors: J M PARKER
Journal: JAMA (1963)

In April 1962 the Alberta Government passed legislation permitting a pharmacist to substitute drugs on a written medical prescription unless the doctor indicated otherwise. The intent was stated to be in the interests of cheaper drugs for the people of Alberta. The legality of this legislature has been questioned in Federal courts of law. The legislation has been formally criticized by the official representatives of medicine and pharmacy on the ground that indiscriminate substitution of drugs is not in the public interest until such time as the quality of all available drugs is assured by governmental or other authoritative agency. It is not within the function of the Food and Drug Directorate to guarantee the quality of drugs sold in Canada, this assurance normally being provided in the trade mark adopted by the manufacturer.
Methadone maintenance: some client opinions
Authors: B S Brown, G J Benn, D R Jansen
Journal: American Journal of Psychiatry (1975)

The authors found similar attitudes toward methadone and methadone treatment programs in 75 detoxification and 115 methadone maintenance clients. Both groups expressed considerable ambivalence--although they viewed methadone as capable of helping them end their herioin addiction, they were concerned about possible methadone dependence and about side effects, both real and imagined. The authors stress the societal context of such concern and suggest that, althought they are not easily allayed, limiting the duration of methadone maintenace from the outset of treatment may be an ameliorative factor.
Observations on Tuberculosis in Europe—Special Methods of Treatment, Government Schemes
Authors: Jabez H. Elliott
Journal: Annals of Internal Medicine (1929)

Article1 July 1929Observations on Tuberculosis in Europe—Special Methods of Treatment, Government SchemesJABEZ H. ELLIOTT, M.B.JABEZ H. ELLIOTT, M.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-1-29 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThese notes were made while in Britain and Europe last autumn as a member of the Canadian Tuberculosis Association tour. We were a party of thirty-two Canadian physicians, all interested in tuberculosis. The party was made up chiefly of sanatorium superintendents, directors of chest clinics, and chiefs of provincial diagnostic services representing every province in the Dominion.Opportunity was offered our party to see the methods of treatment followed in sanatoriums which were visited in England, Wales, Scotland, France, Switzerland and Italy.As with us the underlying principle of treatment for both pulmonary and non-pulmonary forms of tuberculous infection was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Toronto,*Read before the Section of Medicine, Academy of Medicine, March 12th, 1929. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1929Volume 3, Issue 1Page: 29-34KeywordsPulmonary diseasesThorax ePublished: 1 December 2008 Issue Published: 1 July 1929 PDF downloadLoading ...
Micrographia and akinesia
Authors: D R Shackman, T Van Putten, P R May
Journal: American Journal of Psychiatry (1979)

Part of the art of antipsychotic drug therapy is distinguishing side effects from the vicissitudes of schizophrenia. In particular, mild akinesia is evident primarily as a behavioral state of diminished spontaneity characterized by few gestures, unspontaneous speech, apathy, and difficulty initiating usual activities (1). Akinesia is insidious and, particularly when superimposed on chronic schizophrenia, can worsen such negative symptoms as blunting of affect and emotional withdrawal (2). The problem is that akinesia is easily confused with depression, demoralization, or the negative symptoms of schizophrenia, and even experts at times cannot distinguish between a depressive mood shift and an antipsychotic-induced akinesia (3). What is needed is some reliable and readily observable clinical correlate of mild akinesia. Constriction of handwriting (micrographia) has been reported to be a sensitive indicator of extrapyramidal involvement (4-6). According to Haase and Janssen (4) and Angus and Simpson (6), constriction of handwriting precedes observable drug-induced parkinsonism. This notion has gained some measure of acceptance but has seldom been rigorously examined. We conducted the study reported in this paper to determine whether constriction of handwriting is a reliable correlate of mild akinesia.