tbuckley/cabot-search huggingface dataset:
ER stress signaling at the interphase between MASH and HCC
Authors: Younis Hazari, Eric Chevet, Béatrice Bailly-Maitre, Claudio Hetz
Journal: Hepatology (2024)

HCC is the most frequent primary liver cancer with an extremely poor prognosis and often develops on preset of chronic liver diseases. Major risk factors for HCC include metabolic dysfunction–associated steatohepatitis, a complex multifactorial condition associated with abnormal endoplasmic reticulum (ER) proteostasis. To cope with ER stress, the unfolded protein response engages adaptive reactions to restore the secretory capacity of the cell. Recent advances revealed that ER stress signaling plays a critical role in HCC progression. Here, we propose that chronic ER stress is a common transversal factor contributing to the transition from liver disease (risk factor) to HCC. Interventional strategies to target the unfolded protein response in HCC, such as cancer therapy, are also discussed.
Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome
Authors: Fabien Robert, Marie-Caroline Certain, Audrey Baron, Raphaël Thuillet, Léa Duhaut, Mina Ottaviani, Mustapha Kamel Chelgham, Corinne Normand, Nihel Berrebeh, Nicolas Ricard, Valerie Furlan, Agnès Desroches-Castan, Emmanuel Gonzales, Emmanuel Jacquemin, Olivier Sitbon, Marc Humbert, Sabine Bailly, Audrey Coilly, Christophe Guignabert, Ly Tu, Laurent Savale
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

Hepatopulmonary syndrome (HPS) is a severe complication of liver diseases characterized by abnormal dilation of pulmonary vessels, resulting in impaired oxygenation. Recent research highlights the pivotal role of liver-produced BMP-9 (bone morphogenetic protein-9) in maintaining pulmonary vascular integrity.
Optimizing Pharmacotherapy Management of COPD: Don’t Miss the Forest for the Trees
Authors: Jean Bourbeau, Mohit Bhutani, Paul Hernandez, Erika Penz, Darcy D Marciniuk
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Optimizing Pharmacotherapy Management of COPD: Don't Miss the Forest for the Trees." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Impact of long-term transmural plastic stents on recurrence after endoscopic treatment of walled-off pancreatic necrosis
Authors: Rogier P. Voermans, Pieter Jan F. de Jonge, David M de Jong, Pauline M. C. Stassen, Ivo G. Schoots, Robert C. Verdonk, Marco J. Bruno
Journal: Endoscopy (2024)

Abstract Background Endoscopic transmural drainage (ETD) using double-pigtail stents (DPSs) is a well-established treatment for walled-off pancreatic necrosis (WON). This study aimed to compare outcomes in patients undergoing ETD with DPSs left indwelling versus those where stents were removed or migrated. Methods This retrospective multicenter cohort study included patients with WON who underwent ETD using DPSs between July 2001 and December 2019. The primary outcome was recurrence of a pancreatic fluid collection (PFC). Secondary outcomes were long-term complications and recurrence-associated factors. Competing risk regression analysis considered DPS removal or migration as time-varying covariates. Results Among 320 patients (median age 58; 36% women), DPSs were removed in 153 (47.8%), migrated spontaneously in 27 (8.4%), and remained indwelling in 140 (43.8%). PFC recurrence was observed in 57 patients (17.8%): after removal (n = 39; 25.5%); after migration (n = 4; 14.8%); in patients with indwelling DPSs (n = 14; 10.0%). In 25 patients (7.8%), drainage of recurrent PFC was indicated. Risk factors for recurrence were DPS removal or migration (hazard ratio [HR] 3.45, 95%CI 1.37–8.70) and presence of a disconnected pancreatic duct (HR 5.08, 95%CI 1.84–14.0). Conclusions Among patients who undergo ETD of WON, leaving DPSs in situ seems to lower the risk of recurrent fluid collections, without any long-term DPS-related complications. These results suggest that DPSs should not be routinely removed and can be safely left indwelling indefinitely.
A single common target across the world: to make colorectal endoscopic submucosal dissection safer, faster, and easier for R0 resection
Authors: Mathieu Pioche
Journal: Endoscopy (2024)

There is no longer any debate about the value of obtaining an R0 resection for colorectal neoplasia when this is possible, such as during endoscopic submucosal dissection (ESD) because the histological analysis is then of optimal quality, with no information lost [1], and the risk of local recurrence becomes zero, making it possible to avoid checking the colonoscopy at 6 months to look for local recurrence. Recent advances in endoscopic mucosal resection, in particular thermal ablation of the margins, have significantly decreased the recurrence rate in expert centers [2], but these recurrences are still unpredictable and remain frequently very challenging to remove.
TCTAP C-205 A Challenging Case of Massive Acute on Chronic Bilateral Main Pulmonary Artery Embolism Requiring Mechanical Thrombectomy, Catheter Directed Thrombolysis and ECMO
Authors: Ahmad Bakhtiar Md Radzi, Muhammad Hanis Muhmad Hamidi, Huzairi Sani, Raja Ezman Raja Shariff, Khairul Shafiq Ibrahim, Rizmy Najme Khir, Johan Rizwal Ismail, Abdul Wahab Undok, Sazzli Kasim
Journal: Journal of the American College of Cardiology (2024)
TCTAP C-036 A Case of Successful One-Stage Revascularization by Using Rotablator and Lithotripsy (Rotatripsy) in a Patient With ST-Segment Elevation Myocardial Infarction and Undergoing Chemotherapy for Pancreatic Cancer
Authors: Yasunori Inoguchi, Naoki Hayakawa
Journal: Journal of the American College of Cardiology (2024)
Glucagon augments the secretion of FGF21 and GDF15 in MASLD by indirect mechanisms
Authors: Michael M. Richter, Ida M. Kemp, Sara Heebøll, Marie Winther-Sørensen, Sasha A.S. Kjeldsen, Nicole J. Jensen, Janus D. Nybing, Frederik H. Linden, Erik Høgh-Schmidt, Mikael P. Boesen, Sten Madsbad, Frank Vinholt Schiødt, Kirsten Nørgaard, Signe Schmidt, Lise Lotte Gluud, Steen B. Haugaard, Jens J. Holst, Søren Nielsen, Jørgen Rungby, Nicolai J. Wewer Albrechtsen
Journal: Metabolism (2024)

IntroductionGlucagon receptor agonism is currently explored for the treatment of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). The metabolic effects of glucagon receptor agonism may in part be mediated by increases in circulating levels of Fibroblast Growth Factor 21 (FGF21) and Growth Differentiation Factor 15 (GDF15). The effect of glucagon agonism on FGF21 and GDF15 levels remains uncertain, especially in the context of elevated insulin levels commonly observed in metabolic diseases.MethodsWe investigated the effect of a single bolus of glucagon and a continuous infusion of glucagon on plasma concentrations of FGF21 and GDF15 in conditions of endogenous low or high insulin levels. The studies included individuals with overweight with and without MASLD, healthy controls (CON) and individuals with type 1 diabetes (T1D). The direct effect of glucagon on FGF21 and GDF15 was evaluated using our in-house developed isolated perfused mouse liver model.ResultsFGF21 and GDF15 correlated with plasma levels of insulin, but not glucagon, and their secretion were highly increased in MASLD compared with CON and T1D. Furthermore, FGF21 levels in individuals with overweight with or without MASLD did not increase after glucagon stimulation when insulin levels were kept constant. FGF21 and GDF15 levels were unaffected by direct stimulation with glucagon in the isolated perfused mouse liver.ConclusionThe glucagon-induced secretion of FGF21 and GDF15 are augmented in MASLD and may depend on insulin. Thus, glucagon receptor agonism may augment its metabolic benefits in patients with MASLD through enhanced secretion of FGF21 and GDF15.
TCTAP C-065 LMT True Bifurcation Lesion and Reocclusion in Mid LAD After DES Removal due to DCA Catheter
Authors: Mayu Sakuma, Yuji Oikawa, Koichiro Hori, Mikio Kishi, Hiroto Kano, Shunsuke Matsuno, Junji Yajima
Journal: Journal of the American College of Cardiology (2024)
TCTAP C-123 Transient Collateral Augmentation: A Saviour During the Storm
Authors: Devan Jothiprahasam, Prem Arumuganathan, Muhamad Ali SK Abdul Kader, Kamaraj Selvaraj, Mohd Ruslan Mustapa, Abd Kahar Abd Ghapar
Journal: Journal of the American College of Cardiology (2024)
TCTAP C-169 Worse Than Being Blind Is Having Sight but No Vision. A Challenging Situation: Left Main PCI in Patient With Severe Contrast Media Reaction
Authors: Korakoth Towashiraporn, Nattawut Wongpraparut, Songpop Chongthaveepol, Wisakha Anusorn
Journal: Journal of the American College of Cardiology (2024)
TCTAP C-106 Retrieval of a Partially Degloved and Distorted Coronary Stent – The Snare to the Rescue
Authors: Boon Cong Beh, Shawal Faizal Mohamad, Mohd Asyiq Al-Fard Bin Mohd Raffali, Noor Diyana binti Mohamad Farouk, Hamat Hamdi Che Hassan
Journal: Journal of the American College of Cardiology (2024)
TCTAP A-027 Efficacy of Bioresorbable Scaffolds in Percutaneous Coronary Intervention for Chronic Total Occlusion - A 6-Year Follow-Up Analysis
Authors: Dace Sondore, Ieva Briede, Matiss Linde, Karlis Trusinskis, Inga Narbute, Sanda Jegere, Aigars Lismanis, Indulis Kumsars, Karlis Grikis, Andrejs Erglis
Journal: Journal of the American College of Cardiology (2024)
Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapy
Authors: Qin Zhou, Xinyi Tu, Xiaonan Hou, Jia Yu, Fei Zhao, Jinzhou Huang, Jake Kloeber, Anna Olson, Ming Gao, Kuntian Luo, Shouhai Zhu, Zheming Wu, Yong Zhang, Chenyu Sun, Xiangyu Zeng, Kenneth J. Schoolmeester, John S. Weroha, Xiwen Hu, Yanxia Jiang, Liewei Wang, Robert W. Mutter, Zhenkun Lou
Journal: Drug Resistance Updates (2024)
Sleep hygiene – What do we mean? A bibliographic review
Authors: Carla De Pasquale, Mary El Kazzi, Kate Sutherland, Alexandra E. Shriane, Grace E. Vincent, Peter A. Cistulli, Yu Sun Bin
Journal: Sleep Medicine Reviews (2024)

There is no consensus on the definition of sleep hygiene and its components. We examined the definition of sleep hygiene based on its use in published studies. Four databases (Medline, EMBASE, PsycINFO and CINAHL) were searched from inception until December 31, 2021 for the phrase 'sleep hygiene' in the title or abstract. We identified 548 relevant studies in adults: 250 observational and 298 intervention studies. A definition of sleep hygiene was provided in only 44% of studies and converged on three themes: behavioural factors, environmental factors, and an aspect of control. Sleep hygiene components were explicitly defined in up to 70% of observational studies, but in only 35% of intervention studies. The most commonly considered components of sleep hygiene were caffeine (in 51% of studies), alcohol (46%), exercise (46%), sleep timing (45%), light (42%), napping (39%), smoking (38%), noise (37%), temperature (34%), wind-down routine (33%), stress (32%), and stimulus control (32%), although the specific details of each component varied. Lack of consistency in definitions of sleep hygiene and its components may hinder communication between researchers, clinicians, and the public, and likely limits the utility of sleep hygiene as an intervention.
Advancing cancer immunotherapy through siRNA-based gene silencing for immune checkpoint blockade
Authors: Youngjin Choi, Su Hyun Seok, Hong Yeol Yoon, Ju Hee Ryu, Ick Chan Kwon
Journal: Advanced Drug Delivery Reviews (2024)

Cancer immunotherapy represents a revolutionary strategy, leveraging the patient's immune system to inhibit tumor growth and alleviate the immunosuppressive effects of the tumor microenvironment (TME). The recent emergence of immune checkpoint blockade (ICB) therapies, particularly following the first approval of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitors like ipilimumab, has led to significant growth in cancer immunotherapy. The extensive explorations on diverse immune checkpoint antibodies have broadened the therapeutic scope for various malignancies. However, the clinical response to these antibody-based ICB therapies remains limited, with less than 15% responsiveness and notable adverse effects in some patients. This review introduces the emerging strategies to overcome current limitations of antibody-based ICB therapies, mainly focusing on the development of small interfering ribonucleic acid (siRNA)-based ICB therapies and innovative delivery systems. We firstly highlight the diverse target immune checkpoint genes for siRNA-based ICB therapies, incorporating silencing of multiple genes to boost anti-tumor immune responses. Subsequently, we discuss improvements in siRNA delivery systems, enhanced by various nanocarriers, aimed at overcoming siRNA's clinical challenges such as vulnerability to enzymatic degradation, inadequate pharmacokinetics, and possible unintended target interactions. Additionally, the review presents various combination therapies that integrate chemotherapy, phototherapy, stimulatory checkpoints, ICB antibodies, and cancer vaccines. The important point is that when used in combination with siRNA-based ICB therapy, the synergistic effect of traditional therapies is strengthened, improving host immune surveillance and therapeutic outcomes. Conclusively, we discuss the insights into innovative and effective cancer immunotherapeutic strategies based on RNA interference (RNAi) technology utilizing siRNA and nanocarriers as a novel approach in ICB cancer immunotherapy.
Integrin β1–mediated mast cell immune-surveillance of blood vessel content
Authors: Kristina Link, Lina Muhandes, Anastasia Polikarpova, Tim Lämmermann, Michael Sixt, Reinhard Fässler, Axel Roers
Journal: Journal of Allergy and Clinical Immunology (2024)

IgE-mediated degranulation of mast cells (MCs) provides rapid protection against environmental hazards, including animal venoms. A fraction of tissue-resident MCs intimately associates with blood vessels. These perivascular MCs were reported to extend projections into the vessel lumen and to be the first MCs to acquire intravenously injected IgE, suggesting that IgE loading of MCs depends on their vascular association.
The effects of loving-kindness interventions on positive and negative mental health outcomes: A systematic review and meta-analysis
Authors: Julia Petrovic, Jessica Mettler, Sohyun Cho, Nancy L. Heath
Journal: Clinical Psychology Review (2024)

Loving-kindness meditations involve sending feelings of kindness and care to a series of people including oneself, loved ones, strangers, and all beings. Loving-kindness interventions (LKIs), which include knowledge and/or practice related to loving-kindness, have been gaining attention as a potential intervention for improving mental health in adults. This meta-analysis synthesized the effects of LKIs on both positive (i.e., mindfulness, compassion, positive affect) and negative (i.e., negative affect, psychological symptoms) indices of mental health across comparison types (i.e., passive control, active control, alternative treatment) and general sample types (i.e., community, university), and explored characteristics of LKIs that may impact their effectiveness (i.e., intervention format, intervention length, presence/absence of a live facilitator). Following a systematic review of six databases in November 2023, 23 randomized controlled studies met eligibility criteria and were included in the review. Relative to passive control groups, LKIs had positive effects on mindfulness, compassion, positive affect, negative affect, and psychological symptoms; these effects were non-significant relative to active control groups and alternative therapeutic treatments. Notably, the effects of LKIs did not differ as a function of sample type, intervention format, intervention length, or the presence/absence of a live facilitator. Findings provide support for the effectiveness of LKIs relative to passive control conditions, as well as their potential comparability to alternative evidence-based therapeutic treatments, and provide insight into resource-effective approaches to the delivery of effective LKIs. However, additional studies are needed to confirm the impacts of LKIs relative to other interventions in the field.
The gonadal niche safeguards human fetal germline cell development following maternal SARS-CoV-2 infection
Authors: Shijun Shen, Mengting Wang, Xiaocui Li, Beiying Wang, Wei Hong, Wei Li, Ben Xu, Zhenxiang Guo, Ruichen Han, Shanru Yi, Zhiping Wu, Xiaoying He, Liping Wang, Qianshu Zhu, Guang Yang, Hong Wang, Qiaolin Deng, Jiayu Chen, Shaorong Gao, Cizhong Jiang, Rui Gao
Journal: Cell Reports Medicine (2024)

During pregnancy, germline development is vital for maintaining the continuation of species. Recent studies have shown increased pregnancy risks in COVID-19 patients at the perinatal stage. However, the potential consequence of infection for reproductive quality in developing fetuses remains unclear. Here, we analyze the transcriptome and DNA methylome of the fetal germline following maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We find that infection at early gestational age, a critical period of human primordial germ cell specification and epigenetic reprogramming, trivially affects fetal germ cell (FGC) development. Additionally, FGC-niche communications are not compromised by maternal infection. Strikingly, both general and SARS-CoV-2-specific immune pathways are greatly activated in gonadal niche cells to protect FGCs from maternal infection. Notably, there occurs an "in advance" development tendency in FGCs after maternal infection. Our study provides insights into the impacts of maternal SARS-CoV-2 infection on fetal germline development and serves as potential clinical guidance for future pandemics.
Effectiveness of Cognitive Stimulation Therapy (CST) for mild to moderate dementia: A systematic literature review and meta-analysis of randomised control trials using the original CST protocol
Authors: Roopal Desai, Wing Gi Leung, Caroline Fearn, Amber John, Joshua Stott, Aimee Spector
Journal: Ageing Research Reviews (2024)

We aimed to conduct a systematic literature review and meta-analysis to evaluate the efficacy of the original 14 session Cognitive Stimulation Therapy (CST) protocol in improving cognitive function and related outcomes in people with mild to moderate dementia.
Prostate Cancer, Version 3.2024
Authors: Edward M. Schaeffer, Sandy Srinivas, Nabil Adra, Yi An, Rhonda Bitting, Brian Chapin, Heather H. Cheng, Anthony Victor D’Amico, Neil Desai, Tanya Dorff, James A. Eastham, Thomas A. Farrington, Xin Gao, Shilpa Gupta, Thomas Guzzo, Joseph E. Ippolito, R. Jeffrey Karnes, Michael R. Kuettel, Joshua M. Lang, Tamara Lotan, Rana R. McKay, Todd Morgan, Julio M. Pow-Sang, Robert Reiter, Mack Roach, Tyler Robin, Stan Rosenfeld, Ahmad Shabsigh, Daniel Spratt, Russell Szmulewitz, Benjamin A. Teply, Jonathan Tward, Richard Valicenti, Jessica Karen Wong, Jenna Snedeker, Deborah A. Freedman-Cass
Journal: Journal of the National Comprehensive Cancer Network (2024)

The NCCN Guidelines for Prostate Cancer include recommendations for staging and risk assessment after a prostate cancer diagnosis and for the care of patients with localized, regional, recurrent, and metastatic disease. These NCCN Guidelines Insights summarize the panel's discussions for the 2024 update to the guidelines with regard to initial risk stratification, initial management of very-low-risk disease, and the treatment of nonmetastatic recurrence.
The Pancreatic Cancer Early Detection (PRECEDE) Study is a Global Effort to Drive Early Detection: Baseline Imaging Findings in High-Risk Individuals
Authors: George Zogopoulos, Ido Haimi, Shenin A. Sanoba, Jessica N. Everett, Yifan Wang, Bryson W. Katona, James J. Farrell, Aaron J. Grossberg, Salvatore Paiella, Kelsey A. Klute, Yan Bi, Michael B. Wallace, Richard S. Kwon, Elena M. Stoffel, Raymond C. Wadlow, Daniel A. Sussman, Nipun B. Merchant, Jennifer B. Permuth, Talia Golan, Maria Raitses-Gurevich, Andrew M. Lowy, Joy Liau, Joanne M. Jeter, James M. Lindberg, Daniel C. Chung, Julie Earl, Teresa A. Brentnall, Kasmintan A. Schrader, Vivek Kaul, Chenchan Huang, Hersh Chandarana, Caroline Smerdon, John J. Graff, Fay Kastrinos, Sonia S. Kupfer, Aimee L. Lucas, Rosalie C. Sears, Randall E. Brand, Giovanni Parmigiani, Diane M. Simeone, _ _
Journal: Journal of the National Comprehensive Cancer Network (2024)

Background: Pancreatic adenocarcinoma (PC) is a highly lethal malignancy with a survival rate of only 12%. Surveillance is recommended for high-risk individuals (HRIs), but it is not widely adopted. To address this unmet clinical need and drive early diagnosis research, we established the Pancreatic Cancer Early Detection (PRECEDE) Consortium. Methods: PRECEDE is a multi-institutional international collaboration that has undertaken an observational prospective cohort study. Individuals (aged 18–90 years) are enrolled into 1 of 7 cohorts based on family history and pathogenic germline variant (PGV) status. From April 1, 2020, to November 21, 2022, a total of 3,402 participants were enrolled in 1 of 7 study cohorts, with 1,759 (51.7%) meeting criteria for the highest-risk cohort (Cohort 1). Cohort 1 HRIs underwent germline testing and pancreas imaging by MRI/MR-cholangiopancreatography or endoscopic ultrasound. Results: A total of 1,400 participants in Cohort 1 (79.6%) had completed baseline imaging and were subclassified into 3 groups based on familial PC (FPC; n=670), a PGV and FPC (PGV+/FPC+; n=115), and a PGV with a pedigree that does not meet FPC criteria (PGV+/FPC–; n=615). One HRI was diagnosed with stage IIB PC on study entry, and 35.1% of HRIs harbored pancreatic cysts. Increasing age (odds ratio, 1.05; P &lt;.001) and FPC group assignment (odds ratio, 1.57; P &lt;.001; relative to PGV+/FPC–) were independent predictors of harboring a pancreatic cyst. Conclusions: PRECEDE provides infrastructure support to increase access to clinical surveillance for HRIs worldwide, while aiming to drive early PC detection advancements through longitudinal standardized clinical data, imaging, and biospecimen captures. Increased cyst prevalence in HRIs with FPC suggests that FPC may infer distinct biological processes. To enable the development of PC surveillance approaches better tailored to risk category, we recommend adoption of subclassification of HRIs into FPC, PGV+/FPC+, and PGV+/FPC– risk groups by surveillance protocols.
Dexrazoxane to Prevent Cardiotoxicity in Adults Treated with Anthracyclines
Authors: Jenica N. Upshaw, Susan K. Parson, Rachel J. Buchsbaum, Ilana Schlam, Kathryn J. Ruddy, Urshila Durani, Narendranath Epperla, Darryl P. Leong
Journal: JACC CardioOncology (2024)