tbuckley/cabot-search huggingface dataset:
Chemoimmunotherapy in Older Adults With Non–Small Cell Lung Cancer
Authors: Hengjia Tu, Yuzhuo Zhang, Zhixuan You
Journal: JAMA Oncology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Normothermic Regional Perfusion Experience of Organ Procurement Organizations in the US
Authors: Marty T. Sellers, Jennifer L. Philip, Aleah L. Brubaker, Roxane L. Cauwels, Kristopher P. Croome, Jordan R. Hoffman, Nikole A. Neidlinger, Andrea M. Reynolds, Anji E. Wall, John M. Edwards
Journal: JAMA Network Open (2024)

Importance Despite the unmet need for donor organs, organ use from donation after circulatory determination of death (DCD) donors has been limited by inferior transplant outcomes. Normothermic regional perfusion (NRP) improves recipient outcomes and organ utilization from DCD donors. There is variability in NRP policies and experience among US organ procurement organizations (OPOs). Objectives To determine OPO experience, identify operational inconsistencies, and explore needs related to NRP. Design, Setting, and Participants This survey study included 55 OPOs in the US that had recovered DCD organs and completed a survey on operational, administrative, and educational components related to NRP in November to December 2023. Data analysis was performed from February to April 2024. Main Outcome and Measures The primary outcome was the number of OPOs participating in and/or anticipating NRP participation. Secondary outcomes were NRP implementation barriers, OPO education practices, and future needs regarding consensus NRP recommendations and standards. Results Of 55 respondents, 11 (20%) were chief executive officers, 8 (15%) were chief operating officers, and 36 (65%) were medical directors or chief clinical officers. Forty-nine OPOs facilitated NRP cases: 26 OPOs (53%) facilitated both thoracoabdominal NRP (TA-NRP) and abdominal NRP (A-NRP) cases, 16 OPOs (33%) facilitated only TA-NRP, and 7 OPOs (14%) facilitated only A-NRP. OPOs reported 606 NRP cases (421 TA-NRP [69%], 185 A-NRP [31%]); median (range) case experience was 8 (1-52). Fifty-two of 55 OPOs (95%) thought standardized guidance documents would be helpful. All 49 OPOs facilitated NRP at a transplant center’s request; 39 (80%) had NRP initiated by a nonlocal transplant center. Twenty-three of 49 OPOs (47%) participated in NRP without a policy and without a policy pending approval. Positive donor hospital feedback was received by 29 OPOs (59%), primarily focused on increased organs transplanted and prerecovery communication. Allocation challenges were experienced by 21 OPOs (43%); their median (range) case volume was higher than those with no reported allocation challenges (11 [3-52] vs 6.5 [1-29]; P = .03). Eleven OPOs (22%) had incorporated NRP into general donor hospital education. Conclusions In this survey study of US OPOs, wide variation existed with respect to NRP experience and practice. Allocation challenges occurred more frequently with increased NRP experience. NRP guidelines and standardization were desired by most OPOs to decrease allocation challenges and maximize the gift of organ donation.
I-mfa, Mesangial Cell TRPC1 Channel, and Regulation of Glomerular Filtration Rate
Authors: Yu Tao, Muyi Liu, Garland Siebert, Paromita Das-Earl, Deena Ibrahim, Nicole Crowe, Suilan Zheng, Rong Ma
Journal: Journal of the American Society of Nephrology (2024)

Background: Inhibitor of MyoD family A (I-mfa) is a cytosolic protein. Its function in kidney is unknown. The aim of the present study was to examine the regulatory role of I-mfa on glomerular filtration rate (GFR). Methods: GFR was measured by transdermal measurement of FITC-sinitrin clearance in conscious wild type (WT) and I-mfa knockout (KO) mice. Cell contractility was assessed in a single human or mouse mesangial cell. Single cell RNA sequence (scRNA-seq), Western blot, and Ca 2+ imaging were used to evaluate the effects of I-mfa on TRPCs at messenger, protein and functional levels in MCs. Results: In KO mice, GFR was significantly lower than that in WT mice. In WT mice, knocking down I-mfa selectively in mesangial cells using targeted nanoparticle/siRNA delivery system significantly decreased GFR. In human mesangial cells, overexpression of I-mfa significantly blunted the Ang II-stimulated contraction, and knockdown of I-mfa significantly enhanced the contractile response. Consistently, the Ang II-induced contraction was significantly augmented in primary mesangial cells isolated from KO mice. The exaggerated response was restored by re-introducing I-mfa. Furthermore, scRNA-seq showed an increase in trpc1 messenger and Western blot showed an increase in TRPC1 protein abundance in I-mfa KO mouse mesangial cells. TRPC1 protein abundance was decreased in HEK cells overexpressing I-mfa. Ca 2+ imaging experiments showed that downregulation of I-mfa significantly enhanced Ang II-stimulated Ca 2+ entry in human mesangial cells. Finally, TRPC1 inhibitor, Pico145 significantly blunted Ang II-induced mesangial cell contraction. Conclusions: I-mfa positively regulated GFR by decreasing mesangial cell contractile function through inhibition of TRPC1-mediated Ca 2+ signaling.
Multiomic integration analysis identifies atherogenic metabolites mediating between novel immune genes and cardiovascular risk
Authors: Robert Carreras-Torres, Iván Galván-Femenía, Xavier Farré, Beatriz Cortés, Virginia Díez-Obrero, Anna Carreras, Ferran Moratalla-Navarro, Susana Iraola-Guzmán, Natalia Blay, Mireia Obón-Santacana, Víctor Moreno, Rafael de Cid
Journal: Genome Medicine (2024)
Chemoimmunotherapy in Older Adults With Non–Small Cell Lung Cancer—Reply
Authors: Hajime Asahina, Yoko Tsukita, Takehiro Tozuka
Journal: JAMA Oncology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Theta Burst Stimulation Protocols for Schizophrenia
Authors: Taro Kishi, Toshikazu Ikuta, Kenji Sakuma, Shun Hamanaka, Yasufumi Nishii, Masakazu Hatano, Shinsuke Kito, Nakao Iwata
Journal: JAMA Network Open (2024)

Importance To date, several theta burst stimulation (TBS) protocols, such as intermittent TBS (iTBS), have been proposed; however, previous systematic reviews have revealed inconsistent efficacy findings in individual TBS studies for schizophrenia. Objective To examine which TBS protocols are associated with the most favorable and acceptable outcomes in adults with schizophrenia. Data Sources The Cochrane Library, PubMed, and Embase databases were searched for studies published before May 22, 2024. Study Selection The inclusion criteria were as follows: (1) published and unpublished randomized clinical trials (RCTs) of any TBS treatment and (2) RCTs including individuals with schizophrenia spectrum disorders, other psychotic disorders, or both. Data Extraction and Synthesis This study followed the Cochrane standards for data extraction and data quality assessment and used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline for reporting. The risk of bias of individual studies was assessed using the second version of the Cochrane risk of bias tool, and the Confidence in Network Meta-Analysis application was used to rate the certainty of evidence for meta-analysis results. At least 2 authors double-checked the literature search, data transfer accuracy, and calculations. Main Outcomes and Measures The primary outcome of this study was improvement in scores related to negative symptoms. Our frequentist network meta-analysis used a random-effects model. The standardized mean difference (SMD) or odds ratio for continuous or dichotomous variables, respectively, was calculated with 95% CIs. Results A total of 30 RCTs of 9 TBS protocols, with 1424 participants, were included. Only iTBS over the left dorsolateral prefrontal cortex (L-DLPFC) was associated with reduced negative symptom scores (SMD, −0.89; 95% CI, −1.24 to −0.55), overall symptom scores (SMD, −0.81; 95% CI, −1.15 to −0.48), Positive and Negative Syndrome Scale general subscale scores (SMD, −0.57; 95% CI, −0.89 to −0.25), depressive symptom scores (SMD, −0.70; 95% CI, −1.04 to −0.37), and anxiety symptom scores (SMD, −0.58; 95% CI, −0.92 to −0.24) and improved overall cognitive impairment scores (SMD, −0.52; 95% CI, −0.89 to −0.15) compared with a sham. However, positive symptom score changes, all-cause discontinuation rate, discontinuation rate due to adverse events, headache incidence, and dizziness incidence did not significantly differ between any TBS protocols and sham. Conclusions and Relevance In this network meta-analysis, iTBS over the L-DLPFC was associated with improved scores for negative, depressive, anxiety, and cognitive symptoms in individuals with schizophrenia and was well tolerated by the participants. Other forms of TBS were not associated with benefit. Further research is needed to assess the potential role of TBS in the treatment of schizophrenia.
Dementia Drugs and Age-Related Macular Degeneration
Authors: Louay Almidani, Pradeep Y. Ramulu
Journal: JAMA Network Open (2024)

Jingya Wang, PhD; Christina Antza, PhD; Wen Hwa Lee, PhD; Jesse Coker, PhD; Pearse A. Keane, MD; Alastair K. Denniston, PhD; Krishnarajah Nirantharakumar, MD; Nicola J. Adderley, PhD
Fecal Immunochemical Test Positivity Threshold vs Multitarget Genetic Stool Testing for Colorectal Cancer Screening
Authors: Fan Yang, Dan Ma
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expanded Newborn Screening Using Genome Sequencing for Early Actionable Conditions
Authors: Alban Ziegler, Carrie Koval-Burt, Denise M. Kay, Sharon F. Suchy, Amber Begtrup, Katherine G. Langley, Rebecca Hernan, Laura M. Amendola, Brenna M. Boyd, Jennifer Bradley, Tracy Brandt, Lilian L. Cohen, Alison J. Coffey, Joseph M. Devaney, Beata Dygulska, Bethany Friedman, Ramsay L. Fuleihan, Awura Gyimah, Sihoun Hahn, Sean Hofherr, Kathleen S. Hruska, Zhanzhi Hu, Médéric Jeanne, Guanjun Jin, D. Aaron Johnson, Haluk Kavus, Rudolph L. Leibel, Steven J. Lobritto, Stephen McGee, Joshua D. Milner, Kirsty McWalter, Kristin G. Monaghan, Jordan S. Orange, Nicole Pimentel Soler, Yeyson Quevedo, Samantha Ratner, Kyle Retterer, Ankur Shah, Natasha Shapiro, Robert J. Sicko, Eric S. Silver, Samuel Strom, Rebecca I. Torene, Olatundun Williams, Vincent D. Ustach, Julia Wynn, Ryan J. Taft, Paul Kruszka, Michele Caggana, Wendy K. Chung
Journal: JAMA (2024)

The feasibility of implementing genome sequencing as an adjunct to traditional newborn screening (NBS) in newborns of different racial and ethnic groups is not well understood.
Non-classical action of Ku70 promotes Treg suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma
Authors: Qianru Huang, Na Tian, Jianfeng Zhang, Shiyang Song, Hao Cheng, Xinnan Liu, Wenle Zhang, Youqiong Ye, Yanhua Du, Xueyu Dai, Rui Liang, Dan Li, Sheng-Ming Dai, Chuan Wang, Zhi Chen, Qianjun Zhou, Bin Li
Journal: Journal of Clinical Investigation (2024)

Ku70, a DNA repair protein, binds to the damaged DNA ends and orchestrates the recruitment of other proteins to facilitate repair of DNA double-strand breaks. Besides its essential role in DNA repair, several studies have highlighted non-classical functions of Ku70 in cellular processes. However, its function in immune homeostasis and anti-tumor immunity remains unknown. Here, we discovered a marked association between elevated Ku70 expression and unfavorable prognosis in lung adenocarcinoma, focusing specifically on increased Ku70 levels in tumor-infiltrated Treg cells. Using a lung-colonizing tumor model of in mice with Treg-specific Ku70 deficiency, we demonstrated that deletion of Ku70 in Treg cells led to a stronger anti-tumor response and slower tumor growth due to impaired immune-suppressive capacity of Treg cells. Furthermore, we confirmed that Ku70 played a critical role in sustaining the suppressive function of human Treg cells. We found that Ku70 bound to FOXP3 and occupied FOXP3-bound genomic sites to support its transcriptional activities. These findings not only unveil a non-homologous end joining (NHEJ)-independent role of Ku70 crucial for Treg suppressive function, but also underscore the potential of targeting Ku70 as an effective strategy in cancer therapy, aiming to both restrain cancer cells and enhance pulmonary anti-tumor immunity.
The de-sulfinylation enzyme sulfiredoxin-1 attenuates hepatic stellate cell activation and liver fibrosis by modulating the PTPN12-NLRP3 axis
Authors: Jong-Won Kim, Hung-Chun Tung, Mengyun Ke, Pengfei Xu, Xinran Cai, Yue Xi, Meishu Xu, Songrong Ren, Yixian Huang, Amit Bhowmik, Kate S. Carroll, Yun Soo Bae, Song Li, Wen Xie
Journal: Hepatology (2024)

Background and Aims: Liver fibrosis is characterized by the progressive scarring of liver tissue. Oxidative stress is a critical causal factor of HSC activation and subsequent liver fibrogenesis, but the mechanism is not fully understood. Cysteine sulfinic acid (Cys-SO 2 H), a modification of reactive cysteine residues, is a unique form of oxidative response that alters the structure and function of proteins. Sulfiredoxin-1 (SRXN1) is responsible for the ATP-dependent reduction of the Cys-SO 2 H to sulfenic acid (Cys-SOH). Approach and Results: We found that the expression of SRXN1 was increased in activated HSCs and in human and mouse fibrotic livers. HSC-specific ablation of Srxn1 or pharmacological inhibition of Srxn1 exacerbated HSC activation and sensitized mice to liver fibrosis. Mechanistically, SRXN1 inhibited HSC activation by desulfinylating the phosphatase protein tyrosine phosphatase nonreceptor type 12 (PTPN12), which enhanced its phosphatase activity and protein stability, leading to decreased tyrosine phosphorylation and reduced activation of the profibrotic inflammasome protein NLRP3 (nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3). The antifibrotic effect of SRXN1 was abolished when NLRP3 was inhibited. In contrast, overexpression of PTPN12 attenuated NLRP3 activation, and this effect was further amplified by the C164A S -sulfinylation–resistant mutant of PTPN12. Conclusions: Our findings have uncovered an important role of SRXN1 and protein S -sulfinylation in HSC activation and liver fibrosis. The SRXN1-PTPN12-NLRP3 axis represents potential therapeutic targets for liver fibrosis.
Simulation-Based Sample Size Estimation in Clinical Trials in Nephrology
Authors: Leila R. Zelnick
Journal: Journal of the American Society of Nephrology (2024)

1Kidney Research Institute and Division of Nephrology, University of Washington, Seattle, WA aCorresponding author: Dr. Leila Zelnick, [email protected], 325 9th Ave., Box 359606, Seattle, WA 98104
The Physicochemical Approach to Acid-Base Balance
Authors: Man S. Oh, Jaime Uribarri
Journal: Journal of the American Society of Nephrology (2024)

1State University of New York, Downstate Medical Center, Brooklyn, NY 2Icahn School of Medicine at Mount Sinai, NY, NY aCorrespondence: Dr. Man S. Oh, SUNY, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, Phone: 718-781-7444, Email: [email protected]
A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction
Authors: Shen Li, Bo Tao, Jijun Wan, Enca Montecino-Rodriguez, Ping Wang, Feiyang Ma, Baiming Sun, Yiqian Gu, Sivakumar Ramadoss, Lianjiu Su, Qihao Sun, Johanna Ten Hoeve, Linsey Stiles, Jeffrey Collins, R Michael van Dam, Mikayla Tamboline, Richard Taschereau, Orian Shirihai, Douglas B Kitchen, Matteo Pellegrini, Thomas Graeber, Kenneth Dorshkind, Shili Xu, Arjun Deb
Journal: Cell Reports Medicine (2024)
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2
Authors: Deguan Lv, Deobrat Dixit, Andrea F Cruz, Leo J Y Kim, Likun Duan, Xin Xu, Qiulian Wu, Cuiqing Zhong, Chenfei Lu, Zachary C Gersey, Ryan C Gimple, Qi Xie, Kailin Yang, Xiaojing Liu, Xiaoguang Fang, Xujia Wu, Reilly L Kidwell, Xiuxing Wang, Shideng Bao, Housheng H He, Jason W Locasale, Sameer Agnihotri, Jeremy N Rich
Journal: Cell Metabolism (2024)
Effects of healthy low-carbohydrate diet and time-restricted eating on weight and gut microbiome in adults with overweight or obesity: Feeding RCT
Authors: Lin Li, Rui Li, Qingying Tian, Yaogan Luo, Ruyi Li, Xiaoyu Lin, Yunjing Ou, Tianyu Guo, Xue Chen, An Pan, JoAnn E Manson, Gang Liu
Journal: Cell Reports Medicine (2024)
A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma
Authors: Amber K Hamilton, Alexander B Radaoui, Matthew Tsang, Daniel Martinez, Karina L Conkrite, Khushbu Patel, Simone Sidoli, Alberto Delaidelli, Apexa Modi, Jo Lynne Rokita, Maria V Lane, Nicholas Hartnett, Raphael D Lopez, Bo Zhang, Chuwei Zhong, Brian Ennis, Daniel P Miller, Miguel A Brown, Komal S Rathi, Pichai Raman, Jennifer Pogoriler, Tricia Bhatti, Bruce Pawel, Tina Glisovic-Aplenc, Beverly Teicher, Stephen W Erickson, Eric J Earley, Kristopher R Bosse, Poul H Sorensen, Kateryna Krytska, Yael P Mosse, Karin E Havenith, Francesca Zammarchi, Patrick H van Berkel, Malcolm A Smith, Benjamin A Garcia, John M Maris, Sharon J Diskin
Journal: Cancer Cell (2024)
Cancer Prevalence across Vertebrates
Authors: Zachary T. Compton, Walker Mellon, Valerie K. Harris, Shawn Rupp, Diego Mallo, Stefania E. Kapsetaki, Mallory Wilmot, Ryan Kennington, Kathleen Noble, Cristina Baciu, Lucia N. Ramirez, Ashley Peraza, Brian Martins, Sushil Sudhakar, Selin Aksoy, Gabriela Furukawa, Orsolya Vincze, Mathieu Giraudeau, Elizabeth G. Duke, Simon Spiro, Edmund Flach, Hannah Davidson, Christopher I. Li, Ashley Zehnder, Trevor A. Graham, Brigid V. Troan, Tara M. Harrison, Marc Tollis, Joshua D. Schiffman, C. Athena Aktipis, Lisa M. Abegglen, Carlo C. Maley, Amy M. Boddy
Journal: Cancer Discovery (2024)

Abstract Cancer is pervasive across multicellular species, but what explains the differences in cancer prevalence across species? Using 16,049 necropsy records for 292 species spanning three clades of tetrapods (amphibians, sauropsids, and mammals), we found that neoplasia and malignancy prevalence increases with adult mass (contrary to Peto’s paradox) and somatic mutation rate but decreases with gestation time. The relationship between adult mass and malignancy prevalence was only apparent when we controlled for gestation time. Evolution of cancer susceptibility appears to have undergone sudden shifts followed by stabilizing selection. Outliers for neoplasia prevalence include the common porpoise (&amp;lt;1.3%), the Rodrigues fruit bat (&amp;lt;1.6%), the black-footed penguin (&amp;lt;0.4%), ferrets (63%), and opossums (35%). Discovering why some species have particularly high or low levels of cancer may lead to a better understanding of cancer syndromes and novel strategies for the management and prevention of cancer. Significance: Evolution has discovered mechanisms for suppressing cancer in a wide variety of species. By analyzing veterinary necropsy records, we can identify species with exceptionally high or low cancer prevalence. Discovering the mechanisms of cancer susceptibility and resistance may help improve cancer prevention and explain cancer syndromes. See related commentary by Metzger, p. 14