tbuckley/cabot-search huggingface dataset:
The regulatory roles and clinical significance of glycolysis in tumor
Authors: Qiqi Qiao, Shunfeng Hu, Xin Wang
Journal: Cancer Communications (2024)

Abstract Metabolic reprogramming has been demonstrated to have a significant impact on the biological behaviors of tumor cells, among which glycolysis is an important form. Recent research has revealed that the heightened glycolysis levels, the abnormal expression of glycolytic enzymes, and the accumulation of glycolytic products could regulate the growth, proliferation, invasion, and metastasis of tumor cells and provide a favorable microenvironment for tumor development and progression. Based on the distinctive glycolytic characteristics of tumor cells, novel imaging tests have been developed to evaluate tumor proliferation and metastasis. In addition, glycolytic enzymes have been found to serve as promising biomarkers in tumor, which could provide assistance in the early diagnosis and prognostic assessment of tumor patients. Numerous glycolytic enzymes have been identified as potential therapeutic targets for tumor treatment, and various small molecule inhibitors targeting glycolytic enzymes have been developed to inhibit tumor development and some of them are already applied in the clinic. In this review, we systematically summarized recent advances of the regulatory roles of glycolysis in tumor progression and highlighted the potential clinical significance of glycolytic enzymes and products as novel biomarkers and therapeutic targets in tumor treatment.
RE: Spatial intratumor heterogeneity of programmed cell death ligand 1 expression predicts poor prognosis in resected non–small cell lung cancer
Authors: Xuewei Wu, Bin Zhang
Journal: JNCI Journal of the National Cancer Institute (2024)

introduces a novel mathematical model for assessing the spatial intra-tumor heterogeneity (ITH) of PD-L1 and investigates its correlation with tumor recurrence and patient prognosis.This study included 239 consecutive surgically resected specimens of non-small cell lung cancer (NSCLC) with pathological stages ranging from IIA to IIIB.Utilizing a texture image analysis-based model, the study determined the spatial heterogeneity Index of PD-L1 (SHIP) for each tumor.The findings demonstrated that
Nanomedicines targeting activated immune cells and effector cells for rheumatoid arthritis treatment
Authors: Yasi Deng, Hao Zheng, Bin Li, Feibing Huang, Yun Qiu, Yupei Yang, Wenbing Sheng, Caiyun Peng, Xing Tian, Wei Wang, Huanghe Yu
Journal: Journal of Controlled Release (2024)
Current status of mannose receptor-targeted drug delivery for improved anti-HIV therapy
Authors: Satish Rojekar, Amol D Gholap, Namdev Togre, Priyanka Bhoj, Clement Haeck, Navnath Hatvate, Nidhi Singh, Jyotsna Vitore, Sagar Dhoble, Snehal Kashid, Vandana Patravale
Journal: Journal of Controlled Release (2024)
Mitochondria-targeted polyprodrug nanoparticles induce mitochondrial stress for immunogenic chemo-photodynamic therapy of ovarian cancer
Authors: Wenjia Zhang, Gui Chen, Ziqi Chen, Xin Yang, Bingchen Zhang, Shengtao Wang, Zibo Li, Yuanyuan Yang, Yifen Wu, Zhigang Liu, Zhiqiang Yu
Journal: Journal of Controlled Release (2024)
Elevated nuclear TDP-43 induces constitutive exon skipping
Authors: Rogger P. Carmen-Orozco, William Tsao, Yingzhi Ye, Irika R. Sinha, Koping Chang, Vickie T. Trinh, William Chung, Kyra Bowden, Juan C. Troncoso, Seth Blackshaw, Lindsey R. Hayes, Shuying Sun, Philip C. Wong, Jonathan P. Ling
Journal: Molecular Neurodegeneration (2024)

Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-function, TDP-43 overexpression has been used to generate in vitro and in vivo model systems.
Retraction Notice to: Long Noncoding RNA LINC00673 Is Activated by SP1 and Exerts Oncogenic Properties by Interacting with LSD1 and EZH2 in Gastric Cancer
Authors: Mingde Huang, Jiakai Hou, Yunfei Wang, Min Xie, Chenchen Wei, Fengqi Nie, Zhaoxia Wang, Ming Sun
Journal: Molecular Therapy (2024)
Bioinspired Genetic and Chemical Engineering of Protein Hydrogels for programable Multi‐responsive Actuation
Authors: Ting Ji, Haoyuan Shi, Xinyi Yang, Hu Li, David L Kaplan, Jingjie Yeo, Wenwen Huang
Journal: Advanced Healthcare Materials (2024)

Protein hydrogels with tailored stimuli-responsive features and tunable stiffness have garnered considerable attention due to the growing demand for biomedical soft robotics. However, integrating multiple responsive features toward intelligent yet biocompatible actuators remains challenging. Here, we report a facile approach that synergistically combines genetic and chemical engineering for the design of protein hydrogel actuators with programable complex spatial deformation. Genetically engineered silk-elastin-like proteins (SELPs) were encoded with stimuli-responsive motifs and enzymatic crosslinking sites via simulation-guided genetic engineering strategies. Chemical modifications of the recombinant proteins were also used as secondary control points to tailor material properties, responsive features, and anisotropy in SELP hydrogels. As a proof-of-concept example, diazonium coupling chemistry was exploited to incorporate sulfanilic acid groups onto the tyrosine residues in the elastin domains of SELPs to achieve patterned SELP hydrogels. These hydrogels can be programmed to perform various actuations, including controllable bending, buckling, and complex deformation under external stimuli, such as temperature, ionic strength, or pH. With the inspiration of genetic and chemical engineering in natural organisms, this work offers a predictable, tunable, and environmentally sustainable approach for the fabrication of programmed intelligent soft actuators, with implications for a variety of biomedical materials and bio-robotics needs. This article is protected by copyright. All rights reserved.
Evaluating Performance of Different RNA Secondary Structure Prediction Programs Using Self-cleaving Ribozymes
Authors: Fei Qi, Junjie Chen, Yue Chen, Jianfeng Sun, Yiting Lin, Zipeng Chen, Philipp Kapranov
Journal: Genomics Proteomics & Bioinformatics (2024)

Accurate identification of the correct, biologically relevant RNA structures is critical to understanding various aspects of RNA biology since proper folding represents the key to the functionality of all types of RNA molecules and plays pivotal roles in many essential biological processes. Thus, a plethora of approaches have been developed to predict, identify, or solve RNA structures based on various computational, molecular, genetic, chemical, or physicochemical strategies. Purely computational approaches hold distinct advantages over all other strategies in terms of the ease of implementation, time, speed, cost, and throughput, but they strongly underperform in terms of accuracy that significantly limits their broader application. Nonetheless, the advantages of these methods led to a steady development of multiple in silico RNA secondary structure prediction approaches including recent deep learning-based programs. Here, we compared the accuracy of predictions of biologically relevant secondary structures of dozens of self-cleaving ribozyme sequences using seven in silico RNA folding prediction tools with tasks of varying complexity. We found that while many programs performed well in relatively simple tasks, their performance varied significantly in more complex RNA folding problems. However, in general, a modern deep learning method outperformed the other programs in the complex tasks in predicting the RNA secondary structures, at least based on the specific class of sequences tested, suggesting that it may represent the future of RNA structure prediction algorithms.
RET overexpression leads to increased brain metastatic competency in luminal breast cancer
Authors: Petra Jagust, Aoibhin M Powell, Mihaela Ola, Louise Watson, Ana de Pablos-Aragoneses, Pedro García- Gómez, Ramón Fallon, Fiona Bane, Mona Heiland, Gareth Morris, Brenton Cavanagh, Jason McGrath, Daniela Ottaviani, Aisling Hegarty, Sinéad Cocchiglia, Kieron J Sweeney, Stephen MacNally, Francesca M Brett, Jane Cryan, Alan Beausang, Patrick Morris, Manuel Valiente, Arnold D K Hill, Damir Varešlija, Leonie S Young
Journal: JNCI Journal of the National Cancer Institute (2024)

Abstract Background Breast cancer brain metastasis is a rising occurrence, necessitating a better understanding of the mechanisms involved for effective management. Breast cancer brain metastases diverge notably from the primary tumor, with gains in kinase and concomitant losses of steroid signaling observed. In this study, we explored the role of the kinase receptor RET in promoting breast cancer brain metastases and provide a rationale for targeting this receptor. Methods RET expression was characterized in a cohort of patients with primary and brain metastatic tumors. RET functionality was assessed using pharmacological inhibition and gene silencing in patient-derived brain metastatic tumor explants and in vivo models, organoid models, and brain organotypic cultures. RNA sequencing was used to uncover novel brain metastatic relevant RET mechanisms of action. Results A statistically significant enrichment of RET in brain metastases was observed in estrogen receptor–positive breast cancer, where it played a role in promoting cancer cell adhesion, survival, and outgrowth in the brain. In vivo, RET overexpression enhanced brain metastatic competency in patient-derived models. At a mechanistic level, RET overexpression was found to enhance the activation of gene programs involved in cell adhesion, requiring EGFR cooperation to deliver a pro–brain metastatic phenotype. Conclusion Our results illustrate, for the first time, the role of RET in regulating colonization and outgrowth of breast cancer brain metastasis and provide data to support the use of RET inhibitors in the management strategy for patients with breast cancer brain metastases.
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer
Authors: Rashmi Bharti, Goutam Dey, Debjit Khan, Alex Myers, Olivia G. Huffman, Caner Saygin, Chad Braley, Elliott Richards, Naseer Sangwan, Belinda Willard, Justin D. Lathia, Paul L. Fox, Feng Lin, Babal Kant Jha, J. Mark Brown, Jennifer S. Yu, Mohammed Dwidar, Amy Joehlin-Price, Roberto Vargas, Chad M. Michener, Michelle S. Longworth, Ofer Reizes
Journal: Molecular Cancer (2024)

Abstract Background Platinum resistance is the primary cause of poor survival in ovarian cancer (OC) patients. Targeted therapies and biomarkers of chemoresistance are critical for the treatment of OC patients. Our previous studies identified cell surface CD55, a member of the complement regulatory proteins, drives chemoresistance and maintenance of cancer stem cells (CSCs). CSCs are implicated in tumor recurrence and metastasis in multiple cancers. Methods Protein localization assays including immunofluorescence and subcellular fractionation were used to identify CD55 at the cell surface and nucleus of cancer cells. Protein half-life determinations were used to compare cell surface and nuclear CD55 stability. CD55 deletion mutants were generated and introduced into cancer cells to identify the nuclear trafficking code, cisplatin sensitivity, and stem cell frequency that were assayed using in vitro and in vivo models. Detection of CD55 binding proteins was analyzed by immunoprecipitation followed by mass spectrometry. Target pathways activated by CD55 were identified by RNA sequencing. Results CD55 localizes to the nucleus of a subset of OC specimens, ascites from chemoresistant patients, and enriched in chemoresistant OC cells. We determined that nuclear CD55 is glycosylated and derived from the cell surface pool of CD55. Nuclear localization is driven by a trafficking code containing the serine/threonine (S/T) domain of CD55. Nuclear CD55 is necessary for cisplatin resistance, stemness, and cell proliferation in OC cells. CD55 S/T domain is necessary for nuclear entry and inducing chemoresistance to cisplatin in both in vitro and in vivo models. Deletion of the CD55 S/T domain is sufficient to sensitize chemoresistant OC cells to cisplatin. In the nucleus, CD55 binds and attenuates the epigenetic regulator and tumor suppressor ZMYND8 with a parallel increase in H3K27 trimethylation and members of the Polycomb Repressive Complex 2. Conclusions For the first time, we show CD55 localizes to the nucleus in OC and promotes CSC and chemoresistance. Our studies identify a therapeutic mechanism for treating platinum resistant ovarian cancer by blocking CD55 nuclear entry.
ROS-responsive biomimetic nanosystem camouflaged by hybrid membranes of platelet-exosomes engineered with neuronal targeting peptide for TBI therapy
Authors: Yi Li, Xin Xin, Xun Zhou, Jingzhou Liu, Hangbing Liu, Shuo Yuan, Hanhan Liu, Wenyan Hao, Jiejie Sun, Yuli Wang, Wei Gong, Meiyan Yang, Zhiping Li, Yang Han, Chunsheng Gao, Yang Yang
Journal: Journal of Controlled Release (2024)
Precisely targeted drug delivery by mesenchymal stem cells-based biomimetic liposomes to cerebral ischemia-reperfusion injured hemisphere
Authors: Yun-Fei Dong, Yao-Sheng Li, Hui Liu, Lu Li, Juan-Juan Zheng, Ze-Feng Yang, Yuan-Kai Sun, Zhi-Wei Du, Dong-Hang Xu, Ni Li, Xin-Chi Jiang, Jian-Qing Gao
Journal: Journal of Controlled Release (2024)
A comparison of novel electrocautery-enhanced lumen-apposing metal stents and plastic stents in endoscopic ultrasound-guided drainage of infected walled-off necrosis: a multicenter randomized study
Authors: Jong Ho Moon, Se Woo Park, Yun Nah Lee, Sang Hyub Lee, Seong-Hun Kim, Dong Wook Lee, Chang Min Cho, Sung Bum Kim, Chan Hyuk Park
Journal: Endoscopy (2024)

Abstract Background Although lumen-apposing metal stents (LAMSs) have been increasingly used for walled-off necrosis (WON), their advantages over plastic stents in infected WON are unclear. We investigated the safety and efficacy of a novel electrocautery-enhanced LAMS for managing infected WON. Methods Patients who required endoscopic ultrasound-guided WON drainage were randomly assigned to LAMS or plastic stent groups. The primary outcome was total number of direct endoscopic necrosectomy (DEN) procedures required to achieve clinical success. Secondary outcomes included rates of technical success, clinical success, and adverse events. Results 46 patients were included in the LAMS (n = 23) and plastic stent (n = 23) groups. The median total number of DEN procedures did not differ significantly between the plastic stent group (4 procedures, interquartile range [IQR] 2.5–5.0) and LAMS group (9 procedures, IQR 8.0–9.0) (P = 0.07). The LAMS group demonstrated a significantly higher clinical success rate than the plastic stent group based on intention-to-treat analysis (100% vs. 73.9%, P =0.03) at 8 weeks but not at 4 weeks. Significant bleeding occurred in one patient in the plastic stent group and no patients in the LAMS group. Conclusions We found no significant difference in the total number of DEN procedures between LAMSs and plastic stents for managing infected WON. The only statistically significant finding was a higher clinical success rate at 8 weeks for patients treated with LAMS. The use of LAMS did not result in any adverse events, such as bleeding or buried LAMS syndrome, within the study duration.
Sessile serrated lesion prevalence and factors associated with their detection: a post-hoc analysis of a multinational randomized controlled trial from Asia
Authors: Chin Kimg Tan, Sho Suzuki, Tiing Leong Ang, Xuan Han Koh, Lai Mun Wang, Satimai Aniwan, Han-Mo Chiu, Kannikar Laohavichitra, Sakkarin Chirapongsathorn, Takeshi Yamamura, Chen Ya Kuo, Naohisa Yoshida, Takahito Takezawa, Rungsun Rerknimitr, Hideki Ishikawa, Takuji Gotoda
Journal: Endoscopy (2024)

Sessile serrated lesions (SSLs) are associated with an increased risk of colorectal cancer. Data on the prevalence of SSLs in Asia are limited. We performed this study to estimate the prevalence of SSLs in Asia and to explore endoscopic factors that are associated with SSL detection.
Garsorasib in patients with KRASG12C-mutated non-small-cell lung cancer in China: an open-label, multicentre, single-arm, phase 2 trial
Authors: Ziming Li, Xiaomin Dang, Dingzhi Huang, Shi Jin, Weiwei Li, Jianhua Shi, Xicheng Wang, Yiping Zhang, Zhengbo Song, Junping Zhang, Wu Zhuang, Xuewen Liu, Liyan Jiang, Xiangjiao Meng, Mingfang Zhao, Jianying Zhou, Liangming Zhang, Pingli Wang, Hui Luo, Junquan Yang, Shundong Cang, Xiang Wang, Ling Zhang, Shun Lu, Ziming Li, Xiaomin Dang, Dingzhi Huang, Shi Jin, Weiwei Li, Jianhua Shi, Xicheng Wang, Yiping Zhang, Zhengbo Song, Junping Zhang, Wu Zhuang, Xuewen Liu, Liyan Jiang, Xiangjiao Meng, Mingfang Zhao, Jianying Zhou, Liangming Zhang, Pingli Wang, Hui Luo, Junquan Yang, Shundong Cang, Xiang Wang, Jing Wang, Jiuwei Cui, Yan Yu, Zhihong Zhang, Junguo Lu, Weihua Yang, Gaofeng Li, Jifeng Feng, Dongqing Lv, Lin Wu, Yong Fang, Yan Wang, Yanqiu Zhao, Baoshan Cao, Wei Zhu, Zhixiang Zhuang, Qingshan Li, Mingxi Wang, Huan Zhou, Xiaorong Dong, Sheng Hu, Jian Fang, Chun-Wei Xu, Yihong Zhang, Wenjia Wang, Ziyong Xiang, Zhe Shi, Yaolin Wang, Ling Zhang, Shun Lu
Journal: The Lancet Respiratory Medicine (2024)
The Potential Effectiveness of Front-of-Pack Nutrition Labeling for Improving Population Diets
Authors: Bridget Kelly, See Hoe Ng, Amy Carrad, Simone Pettigrew
Journal: Annual Review of Nutrition (2024)

Nutrition labeling on the front of food packages can support more healthful purchase decisions and encourage favorable reformulation. This systematic literature review applied Cochrane methods to synthesize and appraise the evidence on the effectiveness of front-of-pack labeling (FOPL) on diet-related outcomes and food reformulation to inform policy recommendations. The search was conducted on 11 academic and gray literature databases, from inception to July 2022. Evidence was synthesized using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation), vote counting, and meta-analyses, where appropriate. Overall, 221 articles were included in the review. The randomized controlled trial evidence suggested that, compared with when no FOPL was present, FOPL likely improved consumer understanding of the nutritional quality/content of foods (moderate certainty of evidence), and the healthfulness of food choices (moderate certainty) and purchases (moderate certainty). Interpretive FOPL had a greater effect on these outcomes compared with noninterpretive systems (moderate certainty). There was inconsistency in the best-performing interpretive FOPL system.
The Potential Effectiveness of Nutrient Declarations and Nutrition and Health Claims for Improving Population Diets
Authors: Bridget Kelly, See Hoe Ng, Amy Carrad, Simone Pettigrew
Journal: Annual Review of Nutrition (2024)

Nutrition labeling supports healthier diets by aiding purchase decisions and stimulating reformulation. This systematic literature review applied Cochrane methods to synthesize and appraise evidence on the effectiveness of nutrient declarations and nutrition and health claims on diet-related outcomes. The search spanned 11 academic databases, from inception to July 2022. Evidence was synthesized using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) and vote counting. Data were available from 170 studies. Randomized controlled trials (RCTs) suggest that nutrient declarations likely improved consumer understanding of the nutritional quality/content of foods (moderate certainty) and may improve the healthfulness of choices (low certainty) versus no label. RCT evidence also suggests that claims likely increased consumer perceptions of food healthfulness and increased choice and purchases of labeled foods (both moderate certainty), irrespective of nutritional quality. To improve label understanding and avoid misinterpretation, nutrient declarations may incorporate interpretive elements and claims can apply disqualifying conditions for their usage, on the basis of overall nutritional quality.
Wintersweet‐like Nanohybrids of Titanium‐doped Cerium Vanadate Loaded with Polypyrrole for Tumor Theranostic
Authors: Qianyun Lu, Xiaotong Wang, Xin Fan, Jinguo Lin, Jiayi Hu, Guangxin Duan, Huimin Yu, Zihan Geng, Xingang Wang, Hongliang Dai, Feng Liu, Ling Wen, Hongya Geng
Journal: Advanced Healthcare Materials (2024)

Abstract Compromises between enhanced on‐targeting reactivity and precise real‐time monitoring in the tumor microenvironment (TME) are the main roadblocks for catalytic cancer therapy. The hallmark of a high level of hydrogen peroxide (H 2 O 2 ) and acidic extracellular environment of the hypoxia solid tumor can underpin therapeutic and tracking performance. Herein, this work provides an activatable wintersweet‐like nanohybrid consisting of titanium (Ti) doped cerium vanadate nanorods with the modification of polypyrrole (PPy) nanoparticles (CeVO 4 ‐Ti@PPy) for combinatorial therapies of breast carcinoma. The Ti dopants in the size‐controllable CeVO 4 nanorods lower the energy barrier (0.5 eV) of the rate‐determining steps and elaborate peroxidase‐like (POD‐like) activities to improve the generation of toxic hydroxyl radical (·OH) according to the density functional theory (DFT) calculation. The multiple enzyme‐like activities, including the intrinsic glutathione peroxidase (GPx) and catalase (CAT), achieve a record‐high therapeutic efficiency. Coupling this oxidative stress with the photothermal effects of PPy enables enhanced catalytic tumor necrosis. The exterior PPy heterogeneous structure can be further doped with protons in the local acidic environment to intensify photoacoustic signals, allowing the non‐invasive accurate tracking of tumors. The theranostic performance displayed negligible attenuated signals in near‐infrared (NIR) windows. This organic‐inorganic nanohybrid with a heterogeneous structure provides the potential to improve the overall outcomes of catalytic therapy.
Type 2 Diabetes
Authors: Allison L. Crawford, Neda Laiteerapong
Journal: Annals of Internal Medicine (2024)

Type 2 diabetes (T2D) is a prevalent disease that increases risk for vascular, renal, and neurologic complications. Prevention and treatment of T2D and its complications are paramount. Many advancements in T2D care have emerged over the past 5 years, including increased understanding of the importance of early intensive glycemic control, mental health, social determinants of health, healthy eating patterns, continuous glucose monitoring, and the benefits of some drugs for preventing cardiorenal disease. This review summarizes the evidence supporting T2D prevention and treatment, focusing on aspects that are commonly in the purview of primary care physicians.
The latest version ChatGPT powered by GPT-4o: what will it bring to the medical field?
Authors: Nan Zhang, Zaijie Sun, Yuchen Xie, Haiyang Wu, Cheng Li
Journal: International Journal of Surgery (2024)

Zhang, Nan MD; Sun, Zaijie MD; Xie, Yuchen BS; Wu, Haiyang MD; Li, Cheng PhD Author Information
Navigating ablation treatment side effects in oral cancer: A call for informed patient care
Authors: Monisha Prasad, Mohmed Isaqali Karobari
Journal: International Journal of Surgery (2024)

Prasad, Monisha; Karobari, Mohmed Isaqali BDS, MSC (Endo), MFDS. RCPS(Galsg), PhD (Endo) Author Information