tbuckley/cabot-search huggingface dataset:
Revisiting Sex Equality With Transcatheter Aortic Valve Replacement Outcomes
Authors: Stephen A. O’Connor, Marie-Claude Morice, Martine Gilard, Martin B. Leon, John G. Webb, Danny Dvir, Josep Rodés-Cabau, Corrado Tamburino, Davide Capodanno, Fabrizio D’Ascenzo, Philippe Garot, Bernard Chevalier, Ghada W. Mikhail, Peter F. Ludman
Journal: Journal of the American College of Cardiology (2015)
Abstract 18053: Six Minute Walk Test and Outcomes in Stable Outpatients with Heart Failure: The Atlanta Cardiomyopathy Consortium
Authors: Vasiliki Georgiopoulou, Song Li, Grigorios Giamouzis, Ayman Tahhan, Sarawut Siwamogsatham, Robert T Cole, Divya Gupta, Catherine N Marti, Sandra B Dunbar, Andreas Kalogeropoulos, Javed Butler
Journal: Circulation (2012)
Fludarabine/Treosulfan/Thiotepa/ATG Conditioning Leads To High Rates Of Long-Term Engraftment and Low Toxicity Enabling The Use Of Mismatched and Unrelated Donors For Transplantation In Haemoglobinopathies
Authors: Josu de la Fuente, Farah O'Boyle, Yvonne Harrington, Nancy O'Brien, Natalie Killeen, Subarna Chakravorty, Leena Karnik, Richard Szydlo, Irene Roberts
Journal: Blood (2013)
Contractile Function During Angiotensin-II Activation
Authors: Min Zhang, Benjamin L. Prosser, Moradeke A. Bamboye, Antonio N.S. Gondim, Celio X. Santos, Daniel Martin, Alessandra Ghigo, Alessia Perino, Alison C. Brewer, Christopher W. Ward, Emilio Hirsch, W. Jonathan Lederer, Ajay M. Shah
Journal: Journal of the American College of Cardiology (2015)

Renin-angiotensin system activation is a feature of many cardiovascular conditions. Activity of myocardial reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (NADPH oxidase 2 or Nox2) is enhanced by angiotensin II (Ang II) and contributes to increased hypertrophy, fibrosis, and adverse remodeling. Recent studies found that Nox2-mediated reactive oxygen species production modulates physiological cardiomyocyte function. This study sought to investigate the effects of cardiomyocyte Nox2 on contractile function during increased Ang II activation. We generated a cardiomyocyte-targeted Nox2-transgenic mouse model and studied the effects of in vivo and ex vivo Ang II stimulation, as well as chronic aortic banding. Chronic subpressor Ang II infusion induced greater cardiac hypertrophy in transgenic than wild-type mice but unexpectedly enhanced contractile function. Acute Ang II treatment also enhanced contractile function in transgenic hearts in vivo and transgenic cardiomyocytes ex vivo. Ang II–stimulated Nox2 activity increased sarcoplasmic reticulum (SR) Ca2+ uptake in transgenic mice, increased the Ca2+ transient and contractile amplitude, and accelerated cardiomyocyte contraction and relaxation. Elevated Nox2 activity increased phospholamban phosphorylation in both hearts and cardiomyocytes, related to inhibition of protein phosphatase 1 activity. In a model of aortic banding–induced chronic pressure overload, heart function was similarly depressed in transgenic and wild-type mice. We identified a novel mechanism in which Nox2 modulates cardiomyocyte SR Ca2+ uptake and contractile function through redox-regulated changes in phospholamban phosphorylation. This mechanism can drive increased contractility in the short term in disease states characterized by enhanced renin-angiotensin system activation.
Dissociation and psychotic symptoms
Authors: S Steingard, F H Frankel
Journal: American Journal of Psychiatry (1985)

The literature on hysterical or brief reactive psychosis reflects great diversity both in clinical description and theoretical formulation. The authors describe the case of a 17-year-old girl who presented with a diagnosis of bipolar affective disorder, rapid cycling type, but who, in fact, was experiencing dissociative episodes manifested as psychotic states. The patient's successful treatment with hypnosis is described, along with the clinical and theoretical implications of the case.
Isotope Phallogram: Preliminary Communication
Authors: N H Townell, A J W Hilson, R J Morgan, Q H Siraj, R Dick
Journal: Journal of the Royal Society of Medicine (1985)

The isotope phallogram is an investigation which uses radioisotope-labelled red cells in the imaging of penile arterial blood flow. In a preliminary series of 12 impotent patients undergoing both internal iliac arteriography and isotope phallography, the penogram index described by Fannous et al. (1982) has been modified to derive an accurate indicator of vascular disease.
变异型克-雅病的早期识别 一些途径有希望,但尚无肯定答案
Authors: Maurizio, Pocchiari, 冯颖
Journal: BMJ (1998)

现在已经有确切的证据说明变异型克-雅病(Creutzfeldt-Jakob 病)的病原体与牛海绵状脑病的病原体相同,但与从典型散发型克-雅病患者分离出来的病原体不同。目前,这两种类型克-雅病都仅可能在死后作出肯定的诊断,临床医师正在为鉴别这两种类型,尤其为尽早识别变异型克-雅病而努
Oral Mucositis After Allogeneic Hematopoietic Stem Cell Transplantation: Important Impact Of The Presence Of Aciclovir-Resistant Herpes Simplex Virus (HSV-1) On Its Occurrence
Authors: Emilie Frobert, Mohamad Sobh, Florence Morfin, Helene Labussiere, Sophie Ducastelle, Lila Gilis, Fiorenza Barraco, Vanessa Escuret, Xavier Thomas, Franck E. Nicolini, Bruno Lina, Mauricette Michallet
Journal: Blood (2013)
Undisclosed payments in research
Authors: J. M Atkinson
Journal: BMJ (2002)

Patients have the right to know motivations of researchersEditor-Rao and Sant Cassia discussed the ethics of undisclosed payments to doctors recruiting patients in clinical trials. 1 For many years now the greater Glasgow community and primary care local research ethics committee has insisted that reference to doctors' payment is included in the patient information sheet that goes to all potential participants.I object to the payment being hidden behind such phrases as "your doctor's research fund will be paid," which a number of medical research ethics committees allow, and I note that the phrase "for the additional work involved" often appears.Although the NHS and NHS Scotland are the remit of two different parliaments, cross border acceptance of approval by medical research ethics committees exists.Patients are also likely to see the NHS as a whole and the ethical principles of doctors and other healthcare professionals as not having regional variations.In the interests of equality (as well as informed consent) British guidelines need to be developed on this and other minimum requirements of information to be given to patients.This could include the amount of payment.My quick, non-random survey of my non-medical family and friends shows that the size of the payment and the potential overall income are underestimated.Other types of personal gain exist for researchers that I also believe potential participants should know about-when the work forms part of the requirements for a degree.Some people who already have a professional qualification and who are using "their" patients in research do not always believe that it is necessary to inform patients that they are registered for a degree for which this research is necessary.Such research may not always reach publication and may be designed as a learning experience rather than a complete piece of research.If patients are to be expected to take part in research for altruistic reasons they have a right to know what reasons motivate the people carrying out the research.
Lesson of the Week: Who spots the spots? Diagnosis and treatment of early meningococcal disease in children
Authors: F A. I Riordan, A. P J Thomson, J. A Sills, C A. Hart
Journal: BMJ (1996)

cephaly and the Dandy-Walker malformation or variant-may develop late in pregnancy and may not be diagnosed from a scan at 18-20 weeks.Ultrasound scanning in experienced hands is a powerful diagnostic tool.To maximise its role in clinical practice, appropriate training, good equipment, and access to expert referral when necessary are all required.New knowledge and improved equipment lead to new diagnoses-for example, the many "markers" of chromosome abnormality-which need to be appropriately investigated to find their true importance and to reduce the anxiety caused to parents when they are identified.7The publication of leaflets giving honest information to health professionals and pregnant women about screening tests in pregnancy is a step in the right direction.However, if evidence based practice is to achieve its goal health professionals need appropri-ate, up to date evidence to be collected and collated.Such evidence is not yet available.
Effects of Exercise Training on Outcomes in Women With Heart Failure
Authors: Ileana L. Piña, Vera Bittner, Robert M. Clare, Ann Swank, Andrew Kao, Robert Safford, Anil Nigam, Denise Barnard, Mary N. Walsh, Stephen J. Ellis, Steven J. Keteyian
Journal: JACC Heart Failure (2014)

The authors hypothesized that the women enrolled in the HF-ACTION (Heart Failure-A Controlled Trial Investigating Outcomes of Exercise TraiNing) trial and randomly assigned to exercise training (ET) would improve functional capacity as measured by peak oxygen uptake (VO2) compared with those in the usual care group. Furthermore, they hypothesized that the improvement in peak VO2 would correlate with prognosis. They explored whether exercise had a differential effect on outcomes in women versus men.There is less evidence for the benefit of ET in women with heart failure (HF) compared with men because of the small numbers of women studied.HF-ACTION was a randomized trial of ET versus usual care in 2,331 patients with class II-IV HF and a left ventricular ejection fraction of ≤35%. Sex differences in the effects of randomized treatment on clinical outcomes were assessed through the use of a series of Cox proportional hazards models, controlling for covariates known to affect prognosis in HF-ACTION.Women had lower baseline peak VO2 and 6-min walk distance than did men (median, 13.4 vs. 14.9 ml/min/kg and 353 vs. 378 m, respectively). An increase in peak VO2 at 3 months was present in women and men in the ET group (mean ± SD; median, 0.88 ± 2.2, 0.80 and 0.77 ± 2.7, 0.60, respectively, women vs. men; p = 0.42). Women randomly assigned to ET had a significant reduction in the primary endpoint, (hazard ratio: 0.74) compared with men (hazard ratio: 0.99) randomly assigned to ET, with a significant treatment-by-sex interaction (p = 0.027).Although there is no significant difference between men and women in the effect of ET on peak VO2 change at 3 months, ET in women with HF is associated with a larger reduction in rate of the combined endpoint of all-cause mortality and hospital stay than in men.
Pregnancy-Associated Atypical Hemolytic Uremic Syndrome (aHUS), Treated with Eculizumab
Authors: Eudokia M. Mandala, Spyridon Gkiouzepas, Efstratios Kasimatis, Christos Lafaras, Parthenis Chalevas, Konstantina Tsioni, Krystallia Kyrka, Dominiki Oikonomidou, Konstantinos Dinas, Aristotelis Loufopoulos, George Efstratiadis, Garipidou Vasilia, Anastasios-Alexandros Garyfallos
Journal: Blood (2014)
Abstract 1574: Lymphocyte GRK2 as a Novel Biological Marker of Alzheimer's Disease
Authors: Francesca Fortunato, Luca Golino, Emma Sanzari, Vincenzo Canonico, Massimo Marchese, Emilia Mayo, Giuseppe Rengo, Fondazione S. Maugeri, Dario Leosco, Walter J Koch, Franco Rengo
Journal: Circulation (2006)

In Alzheimer’s disease (AD), alterations in β-adrenergic receptor (β-AR) signalling have been found in both post-mortem cerebrocortical and peripheral lymphocytes. Decreased β-ARs number, altered β...
Brain hypoxia, minimal brain dysfunction, and schizophrenia
Authors: H A Handford
Journal: American Journal of Psychiatry (1975)

The author hypothesizes that individuals who suffer brain hypoxia prenatally, perinatally, or immediately postnatally constitute a population at risk for minimal brain dysfunction and for schizophrenia in adulthood. This hypothesis has implications for early intervention with children who have MBD and their families and for multidisciplinary management of these cases throughout childhood.
Abstract 2125: Twenty Year Experience with the Gastroepiploic Artery Graft for CABG in 1352 Patients
Authors: Hisayoshi Suma, Hiroaki Tanabe, Akihito Takahashi, Taiko Horii, Tadashi Isomura
Journal: Circulation (2006)

The right gastroepiploic artery (GEA) has been used for coronary artery bypass grafting (CABG) in 1352 patients during 20-years period. There were 1092 males and 260 females with a mean age of 63 y...
The NF-κB pathway regulates sensitivity of the breast cancer line MDA-MB-436 to inhibition of proliferation by the calpain inhibitor ritonavir
Authors: Ranjana Mitra, Anjaiah Srirangam, Howard Edenberg, Harikrishna Nakshatri, David A. Potter
Journal: Cancer Research (2004)

3855   We have demonstrated that the HIV protease inhibitor, ritonavir, blocks the growth of breast cancer lines independent of EGFR, her2, ER or p53 status. Ritonavir inhibits the growth of lines MCF7, T47D, MDA-MB-231, MDA-MB-436 and SKBR3, with IC 50  values in the range of 10-45 μM. In all of these lines, phospho-Akt is down-regulated by ritonavir treatment. By fluorometric analysis of cancer lines, including MDA-MB-231, ritonavir blocks calpain activity in the range of 10-45 μM, but has significant effects on proteasome activity only at higher concentrations, of >60 μM. Because Akt has been implicated in calpain-mediated NF-κB activation, we determined whether NF-κB regulated genes are down-regulated by ritonavir treatment at the IC 50  for the MDA-MB-436 line. Affymetrix cDNA microarray analysis was performed, using the U133 chip set, assayed in quadruplicate. This line was chosen because of its constitutive nuclear NF-κB and our ability to down-regulate nuclear NF-κB by stable over-expression of the IκB-α superrepressor. RNA was isolated from MDA-MB-436 cells at 4 and 8 h of treatment with ritonavir or DMSO vehicle, at the same cell density as used for proliferation assays. The NF-κB regulated genes IL1-β, IL6 and IL8 were modestly down-regulated by 20 to 30% at 4 and 8 h of ritonavir treatment (P 50  of the parental MDA-MB-436, super-repressor expressing MDA-MB-436-IκBαSR, and vector control MDA-MB-436-LXSN lines and found the IC 50  for ritonavir to be 40, 42 and 26 μM, respectively. These findings indicate that calpain inhibition by ritonavir minimally blocks constitutive nuclear NF-κB and that instead constitutive NF-κB plays a role in resistance to ritonavir. We tested this hypothesis by determining whether ritonavir and the proteasome inhibitor PS-341 synergize to block the growth of breast cancer lines expressing constitutive nuclear NF-κB. By isobologram analysis, the combination of the proteasome inhibitor PS-341 and ritonavir resulted in a Chou-Talalay combination index of 0.15, indicating strong synergy. These results suggest that the combination of ritonavir and NF-κB inhibitors may be useful for the development of therapeutic strategies for breast cancers expressing constitutive nuclear NF-κB.
Abstract 17328: Ablation of the Left Atrial Appendage "Stump" to Cure Post Surgical Maze Patients
Authors: Luigi Di Biase, David J. Burkhardt, Prasant Mohanty, Javier Sanchez, Rodney Horton, Rong Bai, Pasquale Santangeli, Sergio Conti, Shane Bailey, G. Joseph Gallinghouse, Steven Hao, Richard Hongo, Salwa Beheiry, William R. Lewis, Andrea Natale
Journal: Circulation (2010)
Science, medicine, and the future: The future of the management of ischaemic heart disease
Authors: D. Crossman
Journal: BMJ (1997)

<h3>Abstract</h3> Ischaemic heart disease will kill over 150 000 people in the next year in Britain, more than any other single disease process, and cost more than £1.4bn in health care alone. Faced with the continuing problems arising from ischaemic heart disease cardiological clinician scientists are moving from technology based solutions to basic sciences. This article explains how basic science may contribute to new understanding and treatments for patients with ischaemic heart disease. Highlighted are three problems which face any clinical cardiologist on a daily basis and for which basic science may provide solutions: the uncertainty of plaque stability in coronary disease; restenosis after percutaneous transluminal angioplasty; and the shortage of organs for cardiac transplant programmes for patients with heart failure.
Abstract 12556: Cx43 Deficiency Is Associated With Dilated Cardiomyopathy In Old Mice That Can Be Rescued By Genetic Ablation Of Its C-terminal Domain
Authors: Esperanza Agullo, Marisol Ruiz-Meana, Rio Aguilar, Elisabet Miro-Casas, Celia Fernandez-Sanz, Mario Delmar, David Garcia-Dorado
Journal: Circulation (2011)

Cx43 has been shown to be involved in cardiomyocyte functions other than electrical impulse propagation, including mitochondrial respiration and energy metabolism. Heterozygous Cx43 deficient mice ...
Abstract 3972: Impact of Metabolic Syndrome on Tissue Characteristics of Angiographically Normal Coronary Lesions: Integrated Backscatter Intravascular Ultrasound Study
Authors: Tetsuya Amano, Tatsuaki Matsubara, Tadayuki Uetani, Hirohiko Ando, Kiminobu Yokoi, Kosuke Arai, Masataka Kato, Nobuyuki Marui, Michio Nanki, Hideki Ishii, Hideo Izawa, Toyoaki Murohara
Journal: Circulation (2006)
Profile of disability in elderly people: estimates from a longitudinal population study
Authors: D Melzer, B McWilliams, C Brayne, T Johnson, J Bond
Journal: BMJ (1999)

Objectives: To provide estimates of the numbers of cognitively impaired and physically disabled elderly people in England and Wales, subdivided by a range of sociodemographic, dependency, care receipt, and survival variables, to support debates on the form and funding of health and welfare programmes.
Abstract 16401: Early Vascular Alterations and Obesity-Related Comorbidities in Childhood Obesity: Role of Adipocytokines
Authors: Sandra Erbs, Ephraim B Beck, Robert Höllriegel, Felix J Woitek, Axel H Linke, Volker Adams, Marcus Sandri, Daniela Friebe, Wieland Kiess, Gerhard C Schuler, Antje Körner
Journal: Circulation (2011)

Adipokines contribute to development and progression of obesity-related disorders. Leptin, nampt and retinol binding protein 4 (RBP4) play an essential role in the regulation of insulin secretion. ...
Abstract P117: Elevated Liver Transaminases are Associated with an Increased Risk of Atrial Fibrillation
Authors: Moritz F Sinner, Na Wang, Joao D Fontes, Michiel Rienstra, Jared W Magnani, Ramachandran S Vasan, Audrey H Calderwood, Michael J Pencina, Lisa M Sullivan, Patrick T Ellinor, Caroline S Fox, Emelia J Benjamin
Journal: Circulation (2012)

Background: For the management of an initial episode of atrial fibrillation (AF), guidelines recommend assessment of liver function tests; nonetheless, the rationale and supporting evidence for the recommendation remain unclear. We tested the hypothesis that elevated liver transaminases, assessed by alanine transaminase (ALT) and aspartate transaminase (AST) are associated with the incidence of AF in a community-based cohort. Methods and Results: From the Framingham Heart Study Original and Offspring cohorts we investigated 3779 participants (mean age 65±10 years, 56.8% females). After up to 10 years of follow-up (29,099 person years), 383 individuals developed AF. We used Cox proportional hazards models to assess the association between liver transaminases and AF incidence, and adjusted the model for established AF risk factors and alcohol consumption. Both ALT and AST showed significant association with incident AF (Table). When we excluded participants with moderate / severe alcohol consumption, the associations for ALT and AST remained consistent (Table). Additional adjustment for C-reactive protein (inflammatory marker) only mildly lowered the effect estimates for both transaminases, but decreased the level of significance (Table). We additionally estimated the ability of transaminasess to predict AF risk. When assessed by the continuous net reclassification improvement, both ALT and AST marginally improved AF risk prediction [ALT: 0.18 (95% confidence interval, 0.07-0.29; p=0.002); AST: 0.16 (95% confidence interval, 0.04-0.28; p=0.003)]. Conclusions: Higher mean levels of ALT and AST, are associated with the incidence of AF, even when adjusted for various established AF risk factors. However, transaminases contribute only subtly towards an improvement in AF risk prediction. Pathophysiologic mechanisms explaining the association are uncertain and merit further investigation.
Prospective Randomized Trial on Radiation Dose Estimates of CT Angiography Applying Iterative Image Reconstruction
Authors: Simon Deseive, Marcus Y. Chen, Grigorios Korosoglou, Jonathon Leipsic, Eugenio Martuscelli, Patricia Carrascosa, Saeed Mirsadraee, Charles White, Martin Hadamitzky, Stefan Martinoff, Anna-Leonie Menges, Bernhard Bischoff, Steffen Massberg, Jörg Hausleiter
Journal: JACC. Cardiovascular imaging (2015)
Neuropsychological impairment and exclusive abuse of sedatives or hypnotics
Authors: H Bergman, S Borg, L Holm
Journal: American Journal of Psychiatry (1980)

In a group of 55 consecutively admitted patients who exclusively abused sedatives or hypnotics, neuropsychological performance was significantly lower and signs of intellectual impairment significantly more often diagnosed than in a matched control group taken from the general population. These results suggest a relationship between abuse of sedatives or hypnotics and cerebral disorder.
Abstract 3065: Mean Left Atrial Free wall and Mitral Lateral Annulus Deformation, Mid Left Atrial Free wall Velocity are Novel Independent Indicators of Clot Formation in Atrial Fibrillation- Combined Results of Observational and Validative Studies.
Authors: Mark C Arokiaraj, Pislaru Cristina, Shamana S Iyengar, Kiron Varghese, Chandrakanth B Patil, Gurappa G Shetty, Santosh M Jaydev
Journal: Circulation (2007)
Psychotherapy during radiotherapy: effects on emotional and physical distress
Authors: B Forester, D S Kornfeld, J L Fleiss, S Thompson
Journal: American Journal of Psychiatry (1985)

The authors determined the effects of ongoing weekly individual psychotherapy on the symptoms of patients undergoing a 6-week course of radiotherapy for cancer. Forty-eight patients were given weekly psychotherapy sessions for 10 weeks; another 52 patients served as control subjects. A statistically significant reduction was found in both emotional and "physical" manifestations of distress in the patients receiving psychotherapy compared with the control group. This was true regardless of gender, ward or private patient status, or knowledge of diagnosis. Patient gender and knowledge of diagnosis did affect the pattern and magnitude of the response to psychotherapy.
Role Of Histone Deacetylase 6 (HDAC6) In The Modulation Of STAT Pathways and Immune Function Of APCs
Authors: Maritza Lienlaf, Patricio Perez-Villarroel, Fengdong Cheng, Calvin K. Lee, Jorge Canales, Tessa Knox, Danay Marante, Sean J Yoder, Karrune V. Woan, Javier Pinilla-Ibarz, Edward Seto, Eduardo M. Sotomayor, Alejandro Villagra
Journal: Blood (2013)