tbuckley/cabot-search huggingface dataset:
Postoperative Outcomes in Tofacitinib-treated Patients with Acute Severe Ulcerative Colitis Undergoing Colectomy
Authors: Charlotte Larson, Jeffrey A Berinstein, Nicholas Tedesco, Jakob Benedict Seidelin, Pernille D Ovesen, Mathieu Uzzan, Aurélien Amiot, Alexandre Nuzzo, David Laharie, Brad D Constant, Lindsey Albenberg, Alaa El-Hussuna, Shrinivas Bishu, Shirely Cohen-Mekelburg, Peter D R Higgins, Casper Steenholdt
Journal: Clinical Gastroenterology and Hepatology (2025)
Efficacy, safety, and immunogenicity of the AS01E-adjuvanted respiratory syncytial virus prefusion F protein vaccine (RSVPreF3 OA) in older adults over three respiratory syncytial virus seasons (AReSVi-006): a multicentre, randomised, observer-blinded, placebo-controlled, phase 3 trial
Authors: Michael G Ison, Alberto Papi, Eugene Athan, Robert G Feldman, Joanne M Langley, Dong-Gun Lee, Isabel Leroux-Roels, Federico Martinon-Torres, Tino F Schwarz, Richard N van Zyl-Smit, Susanna Cuadripani, Quentin Deraedt, Nancy Dezutter, Catherine Gerard, Laurence Fissette, Stebin Xavier, Marie-Pierre David, Aurélie Olivier, Marie Van der Wielen, Dominique Descamps
Journal: The Lancet Respiratory Medicine (2025)
The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance
Authors: Hatim Sati, Elena Carrara, Alessia Savoldi, Paul Hansen, Jacopo Garlasco, Enrica Campagnaro, Simone Boccia, Juan Antonio Castillo-Polo, Eugenia Magrini, Pilar Garcia-Vello, Eve Wool, Valeria Gigante, Erin Duffy, Alessandro Cassini, Benedikt Huttner, Pilar Ramon Pardo, Mohsen Naghavi, Fuad Mirzayev, Matteo Zignol, Alexandra Cameron, Evelina Tacconelli
Journal: The Lancet Infectious Diseases (2025)
The spatiotemporal ecology of Oropouche virus across Latin America: a multidisciplinary, laboratory-based, modelling study
Authors: Carlo Fischer, Anna Frühauf, Lucia Inchauste, Murilo Henrique Anzolini Cassiano, Heriberto Arévalo Ramirez, Karine Barthélémy, Lissete Bautista Machicado, Fernando Augusto Bozza, Carlos Brites, Miguel Mauricio Cabada, César A Cabezas Sánchez, Angie Cervantes Rodríguez, Xavier de Lamballerie, Roxana de Los Milagros Peralta Delgado, Edmilson F de Oliveira-Filho, Mathieu Domenech de Cellès, Carlos Franco-Muñoz, María Paquita García Mendoza, Miladi Gatty Nogueira, Rosa-Margarita Gélvez-Ramírez, Manuel Gonzalez Gonzalez, Eduardo Gotuzzo, Stephanie Kramer-Schadt, Suvi Kuivanen, Katherine Laiton-Donato, Anyela Lozano-Parra, Edward Málaga-Trillo, Dora Valencia Manos Alva, Dorothée Missé, Andres Moreira-Soto, Thiago Moreno Souza, Karen Mozo, Eduardo Martins Netto, Nadine Olk, Johanna Maribel Pachamora Diaz, Célia Pedroso Jorge, Ana Micsuco Pérez Astudillo, Marta Piche-Ovares, Stephane Priet, Bladimiro Rincón-Orozco, Juan José Romero-Zúñiga, Silvia Paola Salgado Cisneros, Andreas Stöcker, Juan Carlos Villalobos Ugalde, Luis Angel Villar Centeno, Moritz Wenzler-Meya, Juan Carlos Zevallos, Jan Felix Drexler
Journal: The Lancet Infectious Diseases (2025)
Corrigendum to “Early childcare arrangements and children's internalizing and externalizing symptoms: an individual participant data meta-analysis of six prospective birth cohorts in Europe” [The Lancet Regional Health – Europe, Volume 45, October 2024, 101036]
Authors: Katharine M Barry, Demetris Avraam, Tim Cadman, Ahmed Elhakeem, Hanan El Marroun, Pauline W Jansen, Anne-Marie Nybo-Andersen, Katrine Strandberg-Larsen, Llúcia González Safont, Raquel Soler-Blasco, Florencia Barreto-Zarza, Jordi Julvez, Martine Vrijheid, Barbara Heude, Marie-Aline Charles, Alexandre Ramchandar Gomajee, Maria Melchior
Journal: The Lancet Regional Health - Europe (2025)
A biodegradable, microstructured, electroconductive and nano-integrated drug eluting patch (MENDEP) for myocardial tissue engineering
Authors: Caterina Cristallini, Daniela Rossin, Roberto Vanni, Niccoletta Barbani, Chiara Bulgheresi, Massimiliano Labardi, Sadia Perveen, Silvia Burchielli, Domiziana Terlizzi, Claudia Kusmic, Silvia Del Ry, Manuela Cabiati, Cheherazade Trouki, Dawid Rossino, Francesca Sergi, Anthea Villano, Giovanni D Aquaro, Giorgia Scarpellino, Federico A Ruffinatti, Sara Amorim, Ricardo A Pires, Rui L Reis, Raffaella Rastaldo, Claudia Giachino
Journal: Bioactive Materials (2025)
A double network composite hydrogel with enhanced transdermal delivery by ultrasound for endometrial injury repair and fertility recovery
Authors: Xin Zhang, Shufang Wang, Siyu Wang, Zeyi Long, Cong Lu, Jianlin Wang, Lijun Yang, Cancan Yao, Bin He, Xihua Chen, Taifeng Zhuang, Xiangbo Xu, Yufeng Zheng
Journal: Bioactive Materials (2025)
Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity
Authors: Nicolas Fonta, Nicolas Page, Bogna Klimek, Margot Piccinno, Giovanni Di Liberto, Sylvain Lemeille, Mario Kreutzfeldt, Anna Lena Kastner, Yusuf I. Ertuna, Ilena Vincenti, Ingrid Wagner, Daniel D. Pinschewer, Doron Merkler
Journal: The Journal of Experimental Medicine (2025)

In chronic inflammatory disorders of the central nervous system (CNS), tissue-resident self-reactive T cells perpetuate disease. The specific tissue factors governing the persistence and continuous differentiation of these cells remain undefined but could represent attractive therapeutic targets. In a model of chronic CNS autoimmunity, we find that oligodendrocyte-derived IL-33, an alarmin, is key for locally regulating the pathogenicity of self-reactive CD8+ T cells. The selective ablation of IL-33 from neo–self-antigen–expressing oligodendrocytes mitigates CNS disease. In this context, fewer self-reactive CD8+ T cells persist in the inflamed CNS, and the remaining cells are impaired in generating TCF-1low effector cells. Importantly, interventional IL-33 blockade by locally administered somatic gene therapy reduces T cell infiltrates and improves the disease course. Our study identifies oligodendrocyte-derived IL-33 as a druggable tissue factor regulating the differentiation and survival of self-reactive CD8+ T cells in the inflamed CNS. This finding introduces tissue factors as a novel category of immune targets for treating chronic CNS autoimmune diseases.
Trajectory of Global Mental Health and Global Physical Health in Breast Cancer Survivorship
Authors: Stephanie L. Pritzl, Robert A. Vierkant, Kathryn J. Ruddy, Daniela L. Stan, Nicole L. Larson, Janet E. Olson, Fergus J. Couch, Alexandra S. Higgins, Shawna L. Ehlers
Journal: Journal of the National Comprehensive Cancer Network (2025)

Background: Breast cancer survivors face a risk of significant psychological distress, which can persist for years after their initial diagnosis. Although numerous guidelines and tools exist to help screen for and measure distress in patients with cancer, additional longitudinal studies are needed to better characterize the trajectory of distress over time. Patients and Methods: We conducted a longitudinal study to evaluate distress and health-related quality of life in patients with breast cancer. Annual assessments included global mental and physical health scores using the Patient-Reported Outcomes Measurement Information System Global-10 (PROMIS-10), posttraumatic stress symptoms using the Impact of Event Scale-Revised (IES-R), and depressive symptoms using the Patient Health Questionnaire-2 (PHQ-2). Eligible participants had stage 0–III breast cancer, with baseline surveys administered within 1 year of diagnosis. Annual follow-up surveys were conducted through year 4 after the baseline survey. Only patients who completed the baseline survey and at least one follow-up survey were included in this analysis. Individuals with stage IV or recurrent breast cancer were excluded. Results: A total of 2,140 individuals were included. Over time, global mental health scores declined slightly, with differences in T-scores from baseline ranging from 0.4 to 0.9. In contrast, global physical health scores improved, with differences in T-scores ranging from 0.3 to 0.6. Mean scores remained in the normative range. Depressive symptoms remained stable throughout the study period, while posttraumatic stress symptoms showed improvement over time. Conclusions: This study provides important longitudinal data on distress subtypes in breast cancer survivors with nonmetastatic disease. Although global mental health declined slightly, depression symptoms remained stable, and posttraumatic stress symptoms improved. Investigation of distress subtypes over time merits further study to advance detection of significant distress across the cancer continuum.
Corrigendum to “Prolonged increase in glutamate whole body and intracellular production in older adults with COPD and healthy controls post-resistance exercise” [Metabolism, Volume 168, July 2025, 156185]
Authors: Robert H Mbilinyi, Nicolaas E P Deutz, Clayton L Cruthirds, Laura E Ruebush, Tarun Sontam, Gabriella A M Ten Have, John J Thaden, Mariëlle P K J Engelen
Journal: Metabolism (2025)
ADH1C maintains the homeostasis of metabolic microenvironment to inhibit steatotic hepatocellular carcinoma
Authors: Kequan Xu, Tiangen Wu, Xiaomian Li, Xiao Zhang, Xinyu Liu, Shuxian Ma, Wenlong Dong, Jialing Yang, Yingyi Liu, Weixian Fang, Yi Ju, Yiran Chen, Caixia Dai, Zheng Gong, Wenzhi He, Zan Huang, Lei Chang, Weijie Ma, Peng Xia, Xi Chen, Yufeng Yuan
Journal: Metabolism (2025)
Cardiovascular adverse events and outcomes after anti-BCMA CAR-T for relapsed and refractory multiple myeloma
Authors: Stefanie Palfi, Lauren C Peres, Himara Koelmeyer, Melissa Alsina, Rachid C Baz, Brandon J Blue, Salvatore Corallo, Gabriel De Avila, Ciara Freeman, Rebecca Gonzalez, Ariel Grajales-Cruz, Kristy Harvey, Hien D Liu, Taiga Nishihori, Guilherme H Oliveira, Laura B Oswald, Omar Castaneda Puglianini, Sruthi Selvakumar, Alexis Behne Sharma, Elicia Wang, Kenneth H Shain, Michael Jain, Frederick L Locke, Mohammed Alomar, Doris K Hansen, Dae Hyun Lee
Journal: Blood Cancer Journal (2025)
Genetic variation in gut microbe as a key regulator of host social behavior in <i>C. elegans</i>
Authors: Ying Li, Ruijie Bai, Yao Zhu, Peng Shi, Tao Wang, Dianshuang Zhou, Jianteng Zhou, Tao Zhu, Xinrong Zhang, Rongrong Gu, Xiaoyue Ding, Hao Chen, Xiangming Wang, Zuobin Zhu
Journal: Gut Microbes (2025)

Gut microbiota have been shown to influence the social behaviors of their hosts, while variations in host genetics can affect the composition of the microbiome. Nonetheless, the degree to which genetic variations in microbial populations impact host behavior, as well as any potential transgenerational effects, remains inadequately understood. Utilizing C. elegans as a model organism, we identified 77 strains of E. coli from a total of 3,983 mutants that significantly enhanced aggregation behavior through various neurobehavioral pathways. This discovery underscores a collaborative regulatory mechanism between microbial genetics and host behavior. Notably, we observed that some mutant bacteria might affect social behavior via the mitochondrial pathway. Additionally, the modulation of social behavior has been identified as a heritable trait in offspring. Our results provide a novel perspective on the regulatory role of microbial genetic variation in host behavior, which may have significant implications for human studies and the development of genetically engineered probiotics aimed at enhancing well-being across generations.
A Wireless Millimeter‐Scale Device for in Vivo Electromagnetic Brain Tumor Therapy by Ultrasound‐Responsive Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> Hydrogel
Authors: Jiahao He, Jie Li, Jinliang Ren, Xiaona Cao, Ting Xu, Chaofeng Liang, Bowen Zhuang, Xudong Lin, Ningning Li, Bingzhe Xu
Journal: Advanced Healthcare Materials (2025)

Abstract Implantable devices that integrate advanced nanomaterials with wireless energy systems represent a transformative approach to tackling brain tumors. Here, a millimeter‐scale implantable device based on an MXene/polyvinyl alcohol (PVA) hydrogel is introduced, designed for precise and minimally invasive brain tumor therapy via tunable alternating electric fields. This device presents a novel approach by combining ultrasonic wireless energy transfer with triboelectric energy harvesting, eliminating the need for in vivo batteries and enabling continuous operation in a completely wireless manner. The system not only optimizes energy harvesting efficiency but also ensures the localized delivery of therapeutic electric fields directly to the tumor site. Its compact size and mechanical flexibility allow for precise implantation in the complex brain environment, offering a minimally invasive solution with enhanced safety and adaptability. Preclinical evaluations using U‐87 MG orthotopic glioblastoma models demonstrate significant tumor growth inhibition and a marked improvement in survival rates, underscoring its therapeutic potential.
Enhancing the bystander effect of antibody-drug conjugate by using a novel caspase-3 cleavable peptide linker to overcome tumor heterogeneity
Authors: Ha Kyeong Lee, Byoungmo Kim, Yoon Gun Ko, Seung Woo Chung, Wan Seob Shim, So-Young Choi, Se-Ra Lee, Sang Yoon Kim, Youngro Byun
Journal: Journal of Controlled Release (2025)
Incidence of major adverse cardiovascular events in patients with rheumatoid arthritis treated with Janus kinase inhibitors compared to biologic disease‐modifying antirheumatic drugs: data from an international collaboration of registries (the "<scp>JAK</scp>‐pot" study)
Authors: Romain Aymon, Denis Mongin, Romain Guemara, Zubeyir Salis, Johan Askling, Denis Choquette, Catalin Codreanu, Daniela Di Giuseppe, Irini Flouri, Doreen Huschek, Kimme L Hyrich, Florenzo Iannone, Tore K Kvien, Burkhard F Leeb, Dan Nordström, Lucia Otero‐Varela, Karel Pavelka, Manuel Pombo‐Suarez, Ana Rodrigues, Ziga Rotar, Prodromos Sidiropoulos, Sella A Provan, Anja Strangfeld, Trokovic Nina, Jakub Zavada, Lianne Kearsley‐Fleet, Delphine S Courvoisier, Axel Finckh, Kim Lauper
Journal: Arthritis & Rheumatology (2025)

Objective To assess the incidence of major adverse cardiovascular events (MACE) in RA patients treated with JAKi, TNF‐inhibitors (TNFi) or biologic Disease‐Modifying Anti‐Rheumatic Drugs with other modes of action (bDMARD‐OMA) in a multi‐country, real‐world population. Methods RA patients from 15 registries in the JAK‐pot collaboration were included. MACE incidence was analysed using two approaches: a within‐registry analysis aggregating country‐specific estimates from registers with &gt;25 incident MACE events through meta‐analysis, and an individual‐level data combined analysis. We used adjusted linear mixed Poisson regression to obtain incidence rate ratios (IRR) of MACE between treatment groups, accounting for multiple treatment courses. Results The study included 73’008 treatment courses (16’417 JAKi, 35’373 TNFi and 21’218 bDMARD‐OMA) and 828 incident MACE among 51’233 patients. Median follow‐up time was 1.3 years, with most of the follow‐up concentrated in the first two years of treatment. Incidence rates were 7.0, 7.6 and 11.8 per 1’000 person‐years for JAKi, TNFi and bDMARD‐OMA, respectively. Compared to TNFi, JAKi (within‐registry adjusted IRR: 0.89, 95%CI 0.63 to 1.25)) had similar incidence rates of MACE and bDMARD‐OMA had higher rates (within‐registry adjusted IRR: 1.35, 95%CI 1.10 to 1.66). Combined analysis showed similar results. Conclusion Observational data from the JAK‐pot collaboration show no evidence of an increase in cardiovascular events during the first 2 years of use with JAKi compared to TNFi in the general RA population.
The role of limited life expectancy in personalised treatment decisions: 1 in 6 patients aged 80+ with a basal cell carcinoma die within 2 years of diagnosis in England
Authors: Opeoluwa Fariyike, Nicholas A Johnson, Birgitta Van Bodegraven, Kate Quirke, Zoe C Venables, James Powell
Journal: British Journal of Dermatology (2025)

This study examines the survival outcomes of elderly patients (aged 80+) diagnosed with basal cell carcinoma (BCC) in England, revealing that nearly half die within 5 years of diagnosis. The findings highlight the potential overtreatment in this population, emphasizing the need for incorporating frailty and life expectancy assessments into personalized treatment decisions to avoid unnecessary surgical risks.
Delving deeper into the pathogenesis and genomics of posttransplant diffuse large B‐cell lymphoma
Authors: Flore Sneyers, Ana‐Lucía Rocha‐Iraizos, Vibeke K. J. Vergote, Daan Dierickx
Journal: HemaSphere (2025)

Abstract Posttransplant lymphoproliferative disorders (PTLDs) are a well‐known complication of solid organ transplantation and allogeneic hematopoietic stem cell transplantation. The diffuse large B‐cell lymphoma subtype (PT‐DLBCL) is the most frequent monomorphic PTLD and is associated with poor prognosis. Transplant recipients have an increased risk of abnormal proliferation of lymphoid cells because of diminished immune surveillance. In about 60% of the cases, Epstein–Barr virus infection seems to contribute to the cancer phenotype. Although clinical and research interest in the disorder has increased during the last two decades, the pathology of the disease remains largely elusive. In this review, we summarize current knowledge of PT‐DLBCL pathogenesis, and we discuss how a better understanding of PT‐DLBCL can lead to improved diagnostics and therapeutic strategies.
Charting brain functional development from birth to 6 years of age
Authors: Weiyan Yin, Tengfei Li, Zhengwang Wu, Sheng-Che Hung, Dan Hu, Yiding Gui, Seoyoon Cho, Yue Sun, Mackenzie Allan Woodburn, Li Wang, Gang Li, Joseph Piven, Jed T Elison, Changwei W Wu, Hongtu Zhu, Jessica R Cohen, Weili Lin
Journal: Nature Human Behaviour (2025)

Early childhood is crucial for brain functional development. Using advanced neuroimaging methods, characterizing functional connectivity has shed light on the developmental process in infants. However, insights into spatiotemporal functional maturation from birth to early childhood are substantially lacking. In this study, we aggregated 1,091 resting-state functional MRI scans of typically developing children from birth to 6 years of age, harmonized the cohort and imaging-state-related bias, and delineated developmental charts of functional connectivity within and between canonical brain networks. These charts revealed potential neurodevelopmental milestones and elucidated the complex development of brain functional integration, competition and transition processes. We further determined that individual deviations from normative growth charts are significantly associated with infant cognitive abilities. Specifically, connections involving the primary, default, control and attention networks were key predictors. Our findings elucidate early neurodevelopment and suggest that functional connectivity-derived brain charts may provide an effective tool to monitor normative functional development.
Functionally distinct GABAergic amacrine cell types regulate spatiotemporal encoding in the mouse retina
Authors: Akihiro Matsumoto, Jacqueline Morris, Loren L Looger, Keisuke Yonehara
Journal: Nature Neuroscience (2025)

GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system. GABAergic neuronal types play important roles in neural processing and the etiology of neurological disorders; however, there is no comprehensive understanding of their functional diversity. Here we perform two-photon imaging of GABA release in the inner plexiform layer of male and female mice retinae (8-16 weeks old) using the GABA sensor iGABASnFR2. By applying varied light stimuli to isolated retinae, we reveal over 40 different GABA-releasing neuron types. Individual types show layer-specific visual encoding within inner plexiform layer sublayers. Synaptic input and output sites are aligned along specific retinal orientations. The combination of cell type-specific spatial structure and unique release kinetics enables inhibitory neurons to sculpt excitatory signals in response to a wide range of behaviorally relevant motion structures. Our findings emphasize the importance of functional diversity and intricate specialization of GABAergic neurons in the central nervous system.
Overcoming extracellular vesicle-mediated fratricide improves CAR T cell treatment against solid tumors
Authors: Wenqun Zhong, Zhiyuan Qin, Ziyan Yu, Jingbo Yang, Dongdong Yan, Nils W Engel, Neil C Sheppard, Yi Fan, Ravi Radhakrishnan, Xiaowei Xu, Leyuan Ma, Serge Y Fuchs, Carl H June, Wei Guo
Journal: Nature Cancer (2025)
GDF15 links adipose tissue lipolysis with anxiety
Authors: Logan K Townsend, Dongdong Wang, Carly M Knuth, Russta Fayyazi, Ahmad Mohammad, Léa J Becker, Evangelia E Tsakiridis, Eric M Desjardins, Zeel Patel, Celina M Valvano, Junfeng Lu, Alice E Payne, Ofure Itua, Kyle D Medak, Daniel M Marko, Jonathan D Schertzer, David C Wright, Shawn M Beaudette, Katherine M Morrison, André C Carpentier, Denis P Blondin, Rebecca E K MacPherson, Jordan G McCall, Marc G Jeschke, Gregory R Steinberg
Journal: Nature Metabolism (2025)

Psychological stress changes both behaviour and metabolism to protect organisms. Adrenaline is an important driver of this response. Anxiety correlates with circulating free fatty acid levels and can be alleviated by a peripherally restricted β-blocker, suggesting a peripheral signal linking metabolism with behaviour. Here we show that adrenaline, the β3 agonist CL316,243 and acute restraint stress induce growth differentiation factor 15 (GDF15) secretion in white adipose tissue of mice. Genetic inhibition of adipose triglyceride lipase or genetic deletion of β-adrenergic receptors blocks β-adrenergic-induced increases in GDF15. Increases in circulating GDF15 require lipolysis-induced free fatty acid stimulation of M2-like macrophages within white adipose tissue. Anxiety-like behaviour elicited by adrenaline or restraint stress is eliminated in mice lacking the GDF15 receptor GFRAL. These data provide molecular insights into the mechanisms linking metabolism and behaviour and suggest that inhibition of GDF15-GFRAL signalling might reduce acute anxiety.
Water and ions binding to extracellular matrix drives stress relaxation, aiding MRI detection of swelling-associated pathology
Authors: Matthias R Kollert, Martin Krämer, Nicholas M Brisson, Victoria Schemenz, Serafeim Tsitsilonis, Taimoor H Qazi, Peter Fratzl, Viola Vogel, Jürgen R Reichenbach, Georg N Duda
Journal: Nature Biomedical Engineering (2025)

Swelling-associated changes in extracellular matrix (ECM) occur in many pathological conditions involving inflammation or oedema. Here we show that alterations in the proportion of loosely bound water in ECM correlate with changes in ECM elasticity and stress relaxation, owing to the strength of water binding to ECM being primarily governed by osmolality and the electrostatic properties of proteoglycans. By using mechanical testing and small-angle X-ray scattering, as well as magnetic resonance imaging (MRI) to detect changes in loosely bound water, we observed that enhanced water binding manifests as greater resistance to compression (mechanical or osmotic), resulting from increased electrostatic repulsion between negatively charged proteoglycans rather than axial contraction in collagen fibrils. This indicates that electrostatic contributions of proteoglycans regulate elasticity and stress relaxation independently of hydration. Our ex vivo experiments in osmotically modulated tendon elucidate physical causes of MRI signal alterations, in agreement with pilot in vivo MRI of inflammatory Achilles tendinopathy. We suggest that the strength of water binding to ECM regulates cellular niches and can be exploited to enhance MRI-informed diagnostics of swelling-associated tissue pathology.