tbuckley/cabot-search huggingface dataset:
Abstract 17315: Comparing Knowledge and Attitudes about CHD Prevention Among Older Women Prior to and After a Cardiac Event
Authors: Leanne L Lefler, Jean C McSweeney, Julie B Meaux, Kiimberly K Garner
Journal: Circulation (2011)

Purpose: Risk factors for coronary heart disease (CHD) are at epidemic proportions among older women but few recognize their actual risk. Our purpose was to compare and contrast knowledge and attitudes concerning CHD prevention among older women without a CHD diagnosis with those who had experienced a cardiac event. Method: Using a mixed-methods design, we measured standard cardiac risk factors to determine actual risk and obtained measures of self-perceived risk among 20 older women, 6-12 months post cardiac event, and 24 community-dwelling women (≥60 years) without a CHD diagnosis. Semi-structured individual qualitative interviews were conducted to query about knowledge and attitudes regarding CHD prevention and risk. Narratives were transcribed verbatim and analyzed using content analysis. Next, constant comparison was used to compare and contrast findings between the two groups with the quantitative risk measures for convergence/divergence of data. Results: Of the 44 women, 30% were African-American and 64% had some college education, with a mean age of 72 years. Despite a mean of 5.84 vs. 4.46 CHD risk factors (event vs. no CHD) indicating “high-risk” for both groups, personal risk perceptions were unrealistically low: 4.47 vs. 1.95 (0-10 scale). Narrative data indicated a general lack of understanding in both groups regarding risk factors and lifestyle behaviors that would reduce probability for experiencing a cardiac event. Few engaged in lifestyle risk factor modification and felt limited control of their health or did not think change was necessary. Most felt that taking daily medications and visiting their Provider were sufficient. They tended to rely on their Provider to recommend behavior changes and did not recall their Provider discussing risk factors or recommending lifestyle modifications. Conclusions: Results provide information that is critically important from which to derive interventions that facilitate primary and secondary prevention for older women with and without CHD. Tailored interventions that consider knowledge and attitudes about CHD risk and risk factors are needed to promote lifestyle behavior modification.
99mTc-TRODAT-1 SPECT as a Potential Neuroimaging Biomarker in Patients With Restless Legs Syndrome
Authors: Chun-Chieh Lin, Yu-Ming Fan, Guan-Yu Lin, Fu-Chi Yang, Chun-An Cheng, Kuo-Cheng Lu, Jen-Cheng Lin, Jiunn-Tay Lee
Journal: Clinical Nuclear Medicine (2015)

Restless legs syndrome (RLS) is a neurological sensory motor disorder of which pathophysiology remains sketchy. The present study was aimed to determine the diagnostic accuracy and potential of SPECT-TRODAT imaging in discriminating patients with RLS from normal individuals.A total of 34 subjects, 22 diagnosed with RLS and 12 classified as normal, were enrolled. Brain SPECT images were acquired 180 minutes after IV injection of 740 to 925 MBq (20-25 mCi) 99mTc-TRODAT-1 using a double-headed γ-camera equipped with high-resolution fan-beam collimators. Regions of interest were drawn over the whole striatum, caudate, and putamen nucleus of each hemisphere on composite images of the 9 slices with the highest basal ganglia activity. The brain SPECT 99mTc-TRODAT-1 imaging was compared with early-stage RLS patients and healthy volunteers groups.SPECT imaging in RLS patients showed reduced radioactivity accumulation in the striatum profile. The major abnormal result observed is the significantly reduced uptake in striatal dopamine transporter density and activity. The symmetric striatal uptake was observed, and striatum dopamine transporter destiny was more impaired in patients with RLS disease. SPECT images also showed significant differences between patients and volunteers.This study supports that symptoms of restless legs resulted from the striatum of the brain dopaminergic system dysfunction.
Abstract 356: CaMKII Cytoplasmic and Nuclear Isoforms Differentially Affect Calcium Handling but Similarly Regulate HDAC/MEF2 Transcriptional Responses
Authors: Tong Zhang, Lars S Maier, Johannes Backs, Donald M Bers, Eric N Olson, Joan Heller Brown
Journal: Circulation (2006)

The δ isoforms of Ca/calmodulin-dependent protein kinase II (CaMKII) predominate in the heart and both nuclear δB and cytoplasmic δC splice variants of CaMKII are present in cardiomyocytes. We hypo...
Abstract 3579: Impaired flow-mediated vasodilatation is associated with increased left ventricular mass in a multi-ethnic population. The Northern Manhattan Study.
Authors: Takuya Hasegawa, Bernadette Boden-Albala, Kazuo Eguchi, Zhezhen Jin, Ralph L Sacco, Marco R Di Tullio, Shunichi Homma
Journal: Circulation (2007)

Introduction: Increased left ventricular mass (LVM) and endothelial dysfunction are important factors for cardiovascular mortality and morbidity. However, it is not clear whether endothelial dysfun...
Abstract 12201: Recellularization Potential of Glutaraldehyde-Free Aortic Valves
Authors: Jesper L Honge, Jonas A Funder, Torben B Pedersen, Pascal M Dohmen, Wolfgang Konertz, J. M Hasenkam
Journal: Circulation (2010)

Objective: Decellularized porcine heart valves treated with deoxycholic acid (DOA) have showed complete recellularization and absence of calcification when implanted into the pulmonary position in ...
Abstract 14360: Very Late Recurrences of Atrial Arrhythmia After Ablation of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy: The Importance of Non Pv Triggers
Authors: Luigi Di Biase, Douglas Gibson, Sakis Themistoklakis, Antonio Raviele, Robert A. Schweikert, Dhanunjay Lakkireddy, Subba Reddy Vanga, Prasant Mohanty, Rong Bai, Pasquale Santangeli, Sanghamitra Mohanty, Agnes Pump, B Mauricio Cereceda, Salwa Beheiry, Richard Hongo, Javier E. Sanchez, G.Joseph Gallinghouse, Rodney Horton, Antonio Dello Russo, Michela Casella, Claude S. Elayi, J. David Burkhardt, Claudio Tondo, Andrea Natale
Journal: Circulation (2011)

Introduction: Radiofrequency catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy (HCM) has shown satisfactory results at the mid and short term follow up. We sough...
Fundamentals of Orthopaedics.
Authors: Mark R. Brinker, Mark D. Miller
Journal: Annals of Internal Medicine (1965)

Basic Science. Overview of Anatomy, The History and Physical Examination and Diagnostic Tests. Musculoskeletal Conditions of Adults. General Principles of Fractures and Dislocations. Pediatric Orthopaedics. Medical Considerations. Orthopaedic Devices and Implants. The Adult Shoulder. The Adult Arm. The Adult Elbow. The Adult Forearm. The Adult Wrist. The Adult Hand. The Adult Cervical Spine. The Adult Thorocolumbar Spine. The Adult Pelvis (Pelvis, Acetabulum, Sacrum, Coccyx). The Adult Hip. The Adult Thigh. The Adult Knee. The Adult Leg. The Adult Ankle. The Adult Foot.
Abstract 1663: Safety of High-Energy (70-Joule) Non-Transvenous Defibrillation Shocks
Authors: William J Havel, John M Bertram, Carolyn B McClay, Rebecca Rose, Kurt D Stromberg
Journal: Circulation (2007)

Background: A non-transvenous ICD offers potential advantages over a transvenous ICD including simplification of the implant procedure and reduced acute and chronic morbidity and mortality associat...
Breast cancer regression under estrogen therapy
Authors: Marc L'Hermite, Claude Robyn, Jean-Claude Heuson, Marcel Rozencweig
Journal: BMJ (1974)

Ethinyl estradiol in doses therapeutically active in advanced breast cancer significantly increased basal prolactin secretion.  Nafoxidine failed to stimulate prolactin secretion and had an inhibitory effect in one case.  Nafoxidine is an estrogen antagonist operating as a competitive inhibitor of estrogen at tissue-specific estrogen receptors.  It also has weak estrogenic actions in postmenopausal women.  Nafoxidine has been found to induce remission in 35% of postmenopausal women with advanced breast cancer.  Since both nafoxidine and ethinyl estradiol are active in this category of patients it is postulated that nafoxidines effect is a re- sult of its estrogen action rather than its estrogen antagonism.
Abstract 15314: Do ICD Implants for Primary Prevention (PP) Meet Center for Medicare Services (CMS) Guidelines? : The Wake Forest Baptist Medical Center (WFBMC) Experience
Authors: Manish Jain, Jordan Allem, Tom Wannenburg, Rick Henderson, Bryon Rubery, Bharathi Upadhya, Tony Simmons
Journal: Circulation (2011)

Background: ICD therapy is effective in reducing mortality in patients (Pts) with cardiomyopathy (CM) with reduced ejection fraction (EF) <35%. However, the benefit of ICD therapy is unclear in pts...
Low Levels of High-Density Lipoprotein Cholesterol and Increased Risk of Cardiovascular Events in Stable Ischemic Heart Disease Patients
Authors: Subroto Acharjee, William E. Boden, Pamela M. Hartigan, Koon K. Teo, David J. Maron, Steven P. Sedlis, William Kostuk, John A. Spertus, Marcin Dada, Bernard R. Chaitman, G.B. John Mancini, William S. Weintraub
Journal: Journal of the American College of Cardiology (2013)
Phase I dose escalation, pharmacokinetic, and biomarker study of imatinib mesylate plus capecitabine in advanced solid tumor malignancies
Authors: J. P. Favaro, W. Petros, T. Hong, N. Fernando, J. C. Bendell, J. P. Gockerman, D. J. George, R. Williams-Truax, A. Nixon, D. Yu, H. Hurwitz
Journal: Journal of Clinical Oncology (2006)

3093 Background: Preclinical data have suggested at least additive antitumor effects when imatinib (I) and 5-FU are combined. The goals of this study were to determine the maximal tolerated dose for the combination of I and capecitabine (C) in solid tumor patients (pts), as well as to describe non-dose limiting toxicities (non-DLT), pharmacokinetics (PK), and pharmacodynamics (PDGFR inhibition in granulation tissue). Methods: 24 pts (12 M, 12 F) with solid tumor malignancies received C plus I using a 21 day (d) cycle. C was dosed BID for 14/21 d. I was dosed QD x 21d. Results: 24 of 24 pts were fully evaluable for toxicity and efficacy. 6 pts were treated at dose level 1 (C 1000 mg/m 2 BID, I 300 mg QD). The only dose limiting toxicity (DLT) at dose level 1 was grade (gr) 3 diarrhea in 1 patient; however 5 of 6 pts required dose reductions in a subsequent cycle. Therefore, the next 18 pts were treated at dose level -1 (C 750 mg/m 2 BID and I 300 mg QD). One DLT (gr 3 fatigue) was seen at dose level -1. Non-DLT gr ¾ toxicities at any point at dose level -1 were gr 4 anemia (n=1) and gr 3 lymphopenia (n=6). Toxicities requiring dose reductions at any point on dose level -1 occurred in 7/18 patients. Gr ½ toxicities found in &gt; 10% of all patients at any point in the trial were anemia (46%), leukopenia (17%), neutropenia (21%), lymphopenia (29%), thrombocytopenia (29%), nausea (71%), anorexia (41%), edema (42%), diarrhea (38%), hand foot syndrome (33%), vomiting (33%), headache (25%), insomnia (25%), skin rash (25%), constipation (21%), stomatitis (17%), lightheadedness (13%), fatigue (13%), numbness/tingling (13%), taste change (13%), and elevated transaminases (13%). 1 pt with carcinoid tumor had a partial response. 1 pt with non-small cell lung cancer had a minor response, and 5/21 pts had stable disease as their best response. 1 pt had stable disease for 8 months and another pt was stable for 6 months. Conculsions: On a 21 d cycle, the recommended phase 2 dose of C plus I is C 750 mg/m 2 BID for 14 d, and I 300 mg QD. [Table: see text]
Abstract 3861: Multiple Lipid Goal Attainment and Improved Cardiovascular Outcomes with Lipid-Modifying Therapy: Analysis of a Collaborative Practice Model versus a General/Specialty Practice Model
Authors: Michael J Ryan, Joan Gibson, Michael McGuire, Mark Cziraky, Chaitanya Sarawate, Ralph Quimbo
Journal: Circulation (2006)

Purpose: This analysis compares drug therapy to achieve optimal lipid profiles (LP) and improve cardiovascular (CV) outcomes in patients (pts) treated in a collaborative practice model (CPM) with t...
Detection of p60 sEGFR by an acridinium linked immunosorbent assay (ALISA)
Authors: Sulay Rivera-Sánchez, Elsa M. Cora
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

85 

Soluble isoforms of the epidermal growth factor receptor (EGFR) are under study as potential serum biomarkers in cancer. p60 sEGFR is one of the EGFR soluble isoforms generated by alternative splicing (Reiter J.L., et al 1996, Nucleic Acids Res. 24: 4050-4056). This 60 kD isoform comprises subdomains I, II and part of III of the extracellular domain of EGFR and contains two unique amino acids at its C-terminal. We have identified this protein in human sera by immunoblot analysis but there is no method to measure the levels of this EGFR isoform. A sensitive method is needed for the evaluation of p60 sEGFR as a serum tumor biomarker. Our goal is to develop an acridinium linked immunosorbent assay (ALISA) to quantify the levels of p60 sEGFR in human fluids. ALISA is a microtiter plate-based method in which a sandwich of antibodies including a capture antibody and a detecting antibody labeled with acridinium is used. To select the antibodies for the p60 sEGFR-specific ALISA, we first evaluated several monoclonal antibodies (MAbs) specific to the extracellular domain of EGFR for the potential to bind p60 sEGFR by immunoprecipitation assay. The MAbs R1, 15E11, and 199.12 did immunoprecipitate p60 sEGFR whereas 528, 225, O.N. 269, O.N 265, 108 and 111.6 did not. Ten different combinations of antibodies were tested by ALISA using one or two of the three antibodies able to immunoprecipitate p60 sEGFR. In the evaluation of each combination, conditioned culture media (CCM) from Qt6 cells stably transfected with the p60 sEGFR cDNA and trpEcentrin were used as the positive and negative analytes, respectively. Four of the ten combinations tested showed a positive dose-response curve when the CCM was used and none response for the negative control. These four combinations (coating antibody + capture antibody + detecting antibody) were: 1) Anti-IgG2b + R1 + 15E11, 2) Anti-IgG2a + 199.12 + 15E11, 3) Anti-IgG2b + R1 + 199.12, and 4) Anti-IgG1 + O.N. 269 + 199.12. Combination 1 and 2 showed higher relative light units (RLU) values compared to combinations 3 and 4. These results suggest that the combinations 1) Anti-IgG2b + R1 + 15E11 and 2) Anti-IgG2a + 199.12 + 15E11 warrant further evaluation to develop the p60 sEGFR-specific ALISA. Supported by UPR-MSC MBRS RISE Program, UPR-MSC MBRS SCORE Program (2-806GM08224) and NIH COBRE (P200RR016439).
Abstract 2007: Effects of Myocardial Viability Assessed by Strain Stress Echocardiography on Diastolic Function in Acute Myocardial Infarction
Authors: Wook-Jin Chung, Mi-Seung Shin, Jeong Min Bong, Woong Chol Kang, Seung Hwan Han, Chan Il Moon, Kwang Kon Koh, Tae Hoon Ahn, In Suk Choi, Eak Kyun Shin
Journal: Circulation (2008)

Purpose: Myocardial viability may influence the diastolic function of left ventricle (LV) reflecting chamber remodeling in the early phase after acute myocardial infarction (AMI). However, the precise relationship in human has not been determined yet. So we aimed to evaluate whether myocardial viability assessed by strain rate parameters on low-dose dobutamine echocardiography (LD-DSE) may influence on LV diastolic function and remodeling process in AMI. Methods: In this prospective single center study, 134 consecutive patients with AMI and akinetic wall motion in at least two segments were enrolled and underwent LD-DSE on 5~9 days after the event. Myocardial viability was quantitatively evaluated by global peak systolic strain rate (psSR) and global time to peak of psSR. Within 6 hours after LD-DSE, left and right heart catheterization with the recording of LV end diastolic pressure and pulmonary capillary wedge pressure were performed. And then 6 months later, echocardiography and thallium scan with delayed image were followed. Results: Patients (67.9% men, mean age 60.1±1.1years, 54.5% anterior wall, 53.7% ST-segment elevation) were tolerated LD-DSE without significant complications. 71.6% of patients underwent revascularization therapy. After 6 months later, LV ejection fraction was significantly increased from 48.7±1.1% to 52.0±1.1% (p=0.00) and LV end diastolic volume was significantly decreased from 94.6±4.0cc to 89.1±3.8cc (p=0.00). As we expected, global psSR at baseline of LD-DSE showed significant linear correlations with LV end diastolic pressure, E/E’ ratio and left atrial volume index (r=−0.43 and p=0.01, r=0.52 and p=0.00 and r=0.52 and p=0.00, respectively). And also global psSR at 10mcg of LD-DSE correlated with E/E’ ratio and left atrial volume index(r=0.52 and p=0.00 and r=0.36 and p=0.02, respectively). Interestingly, global psSR at 10mcg of LD-DSE correlated significantly with the change of LV end diastolic volume during 6 months follow-up (r=−0.42 and p=0.04). Conclusions: Strain rate data on LD-DSE correlates with LV diastolic function in the early phase and chamber remodeling in 6 months follow-up after AMI. So strain stress echocardiography may provide useful prognostic information for LV remodeling in AMI.
Abstract 8910: Clinical Use, Diagnostic Efficiency and Impact on Patient Management of Cardiovascular Magnetic Resonance
Authors: Florian von Knobelsdorff-Brenkenhoff, Angelika Bublak, Sana El-Mahmoud, Ralf Wassmuth, Christian Opitz, Jeanette Schulz-Menger
Journal: Circulation (2011)

Objectives: To evaluate the clinical use, diagnostic efficiency and impact on patient management of cardiovascular magnetic resonance (CMR). Methods : Data of the individual patient and procedural information of 2598 consecutive clinically indicated CMR exams were collected. For a representative subgroup of 250 exams, an external blinded reviewer evaluated the need for diagnostic tests and hospitalization before and after CMR and assessed the impact of CMR on patient management. Results: Table 1 lists the subjects' characteristics and procedural information of all studies. CMR was used in a large variety of indications, with inflammatory (29.4 %) and ischemic (26.2 %) heart disease as the most frequent. All moderate adverse events (0.5 %) were associated with stress medication or contrast media. In the subgroup analysis, CMR ruled out a suspected disease in 63.1%, confirmed a suspected or known disease in 27.8% or detected an unexpected new pathology in 7.2 %. The clinical question was answered completely or partial in 88.4 % and 11.2 %, respectively. CMR reduced the amount of ordered diagnostic tests by 65.7 % and led to an altered diagnostic strategy in the individual patient in 92.4 %. Heart catheterization was cancelled in almost every third patient following CMR (11 / 36), and newly ordered after CMR in additional 6% (12 / 214). In 23.6 %, CMR led to a strategic change between in- or outpatient treatment. Conclusions: CMR is safe, robust and versatile. It influences the indication for hospital admission, the choice and extent of individual downstream diagnostic testing, and the determination of the final diagnosis.
Rates of Infection in Myelofibrosis Patients Treated with Ruxolitinib
Authors: Ahmad Zarzour, Ali Tabarroki, Rokana Taftaf, Valeria Visconte, Jing Ai, Betty K. Hamilton, Nikolaos Papadantonakis, Alan E. Lichtin, Leonard J. Horwitz, Anjali S. Advani, Mikkael A. Sekeres, Ramon V. Tiu
Journal: Blood (2014)
Abstract 3171: Chordal Cutting to Relieve Mitral Leaflet Tethering Diminishes LV Remodeling Following Chronic Inferior Myocardial Infarction
Authors: Emmanuel Messas, Alain Bel, Catherine Szymanski, Iris Cohen, Marc D Handschumacher, Ludovic Trinquart, Michel Desnos, Alain Carpentier, Philippe Menasché, Albert A Hagège, Robert Levine
Journal: Circulation (2007)

Background. We have previously demonstrated that severing two second-order chordae to the anterior mitral leaflet (AL) in sheep does not adversely affect LV size and function acutely. Objectives. This study tested whether chordal cutting exacerbates long-term LV remodeling when applied to treat ischemic mitral regurgitation (MR) in a chronic myocardial infarction (MI). Methods. A posterolateral MI was created in 18 sheep by ligation of obtuse marginal branches. After chronic remodeling and MR development at 2 months, sheep were randomized to sham surgery versus anterior leaflet (AntL) or bileaflet (BiL) second-order chordal cutting (n=6 each), techniques in clinical application. 2D and 3D echo at baseline, chronic infarction (2 months), and follow-up at a mean of 6.5 months post-MI (sacrifice) measured LV end-diastolic and end-systolic volume (EDV and ESV), ejection fraction (EF), wall motion score index (WMSi), and posterior leaflet (PL) restriction angle relative to the annulus. Results. All measurements were comparable among groups at baseline and chronic MI. At sacrifice, AntL and BiL chordal cutting limited the progressive remodeling seen in controls. LVESV increased by 33.0±7.2% and 28.0±5.0% relative to chronic MI with AntL and BiL chordal cutting, versus 109.0±8.7% in controls (p&lt;0.01) (LVESV=60.6±5.1ml vs 61.8±4.1ml vs 82.5±2.6ml in controls). LVEDV increased by 26.0±5.5% and 22.0±3.4% with AntL and BiL chordal cutting, versus 63.0±2.0% in controls (p&lt;0.01). LVEF and WMSi were not significantly different at follow-up among chordal cutting and control groups. MR progressively increased to moderate in controls but decreased to trace-mild (vena contracta ≤2mm) in 83% of chordal cutting sheep. BiL chordal cutting provided greater PL mobility (decreased PL restriction angle to 54±5° versus 93±3° with AntL chordal cutting, p&lt;0.01). Conclusions: Cutting secondary chordae in the chronic post-MI setting does not adversely affect long-term LV remodeling, and limits progressive increases in LV volumes.
Abstract 440: Improved Recovery of Reperfused Mouse Hearts Expressing Slow Skeletal Muscle TnI is Related to Reduced ATP Loss During Ischemia
Authors: Grace M Arteaga, Kayla M Pound, Mathew Fasano, R. John Solaro, E. Douglas Lewandowski
Journal: Circulation (2006)

Previous work shows that transgenic (TG) murine hearts expressing the slow skeletal isoform of cTnI (ssTnI) tolerate acidosis and ischemia/reperfusion (I/R) better than hearts expressing the adult ...