tbuckley/cabot-search huggingface dataset:
Confusion about Cadmium Risks: The Unrecognized Limitations of an Extrapolated Paradigm
Authors: Alfred Bernard
Journal: Environmental Health Perspectives (2015)

Cadmium (Cd) risk assessment presently relies on tubular proteinuria as a critical effect and urinary Cd (U-Cd) as an index of the Cd body burden. Based on this paradigm, regulatory bodies have reached contradictory conclusions regarding the safety of Cd in food. Adding to the confusion, epidemiological studies implicate environmental Cd as a risk factor for bone, cardiovascular, and other degenerative diseases at exposure levels that are much lower than points of departure used for setting food standards.
Die physikalischen und technischen Grundlagen der Messung und Dosierung der Röntgenstrahlen.
Authors: Friedrich Voltz
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Über Carcinome, Sarcome und Lymphomatosis infiltrans bei weissen Mäusen: Versuche menschlichen Cancer auf Versuchstiere zu Übertragen
Authors: Johs. v. Andersen
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1888: Effects of Carperitide (hANP) Treatment on Long-term Prognosis in Patients with Acute Decompensated Heart Failure
Authors: Noritake Hata, Yoshihiko Seino, Takayoshi Tsutamoto, Hidehiko Suzuki, Shinya Hiramitsu, Tsutomu Yoshikawa, Hiroyuki Yokoyama, Keiji Tanaka, Kyoichi Mizuno, Jun Nejima, Masahiko Kinoshita
Journal: Circulation (2006)
America's Human Wealth. The Money Value of Human Life.
Authors: Edward A. Woods, Clarence B. Metzger
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12606: The Influence of Presenting Electrocardiographic Findings on the Treatment and Outcomes of Patients With Non-ST-elevation Myocardial Infarction (NSTEMI)
Authors: Jigar H Patel, Raghav Gupta, Matthew T Roe, S. A Peng, Jorge F Saucedo
Journal: Circulation (2012)

BACKGROUND: The influence of presenting ECG findings on the treatment and outcomes of NSTEMI patients has not been studied in current practice. METHODS: We analyzed clinical characteristics, in-hos...
INDUSTRIAL MEDICAL PROBLEMS IN WAR PRODUCTION
Authors: T. Lyle Hazlett
Journal: Annals of Internal Medicine (1944)

Article1 March 1944INDUSTRIAL MEDICAL PROBLEMS IN WAR PRODUCTIONT. LYLE HAZLETT, M.D., F.A.C.P.T. LYLE HAZLETT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-3-371 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is probably no field of medical endeavor which is less static than Industrial Medicine. This is true primarily for two reasons: first, Industrial Medicine reflects the uninterrupted progress of medicine as a whole and, secondly, within its strictly occupational phases it reflects a multitude of changes which are constantly occurring at a more or less accelerated pace. The extent to which the industrial physician is aware of these changes and the degree to which he adapts his thought and procedure to them determines the value of medicine to industry and to the nation's war effort. We shall review briefly... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania*Presented before the Regional Meeting of the American College of Physicians, Columbus, Ohio, May 14, 1943. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1944Volume 20, Issue 3Page: 371-375 ePublished: 1 December 2008 Issue Published: 1 March 1944 PDF downloadLoading ...
Physiology of the Nerves
Authors: Joh. Müller, Nicholas Wade
Journal: BMJ (1840)

Volume 1. Introduction Nick Wade Containing the Nervous System [1803] Idea of a New Anatomy of the Brain [1811], both by Charles Bell Volume 2. Dr F.J. Gall's System of the Functions of the Brain, extracted from C.A. Blode's account of Dr Gall's lectures, held on the above [sic] subject at Dresden [1807] Carl August Blode Phrenology Examined [1846] Pierre Flourens Volumes 3. and 4. Elements of Physiology [1840, 1843] Johannes Mueller, translated by W. Baly Volume 5. Mind and Body. The Theories of their Relation [1873] Alexander Bain Volume 6. Lectures on the Localization of Cerebral and Spinal Diseases [1883] Jean Martin Charcot, translated by W.B. Hadden Volume 7. The Functions of the Brain [2nd ed. 1886] David Ferrier Volume 8. The Integrative Action of the Nervous System [1906] Charles S. Sherrington
Abstract P159: Causes of Late Death in Patients Discharged Alive after In-hospital Cardiac Arrest: Arrhythmic or Not?
Authors: Wessel Keuper, Nick Clappers, Hendrik-Jan Dieker, Marc A Brouwer, Freek W Verheugt
Journal: Circulation (2008)

Background Survival to discharge after in-hospital cardiopulmonary resuscitation (CPR) is approximately 17%. Data on longer-term survival is scarce and 1-year survival varies between 50 to 80% for patients who survived to discharge. The cause of late death in this patient population is unknown. However, this is of great importance for therapeutic considerations such as prevention of arrhythmic death with an implantable cardiac defibrillator (ICD). Therefore, we obtained long-term survival and the cause of death of patients surviving to discharge after in-hospital cardiac arrest. Methods Single centre study of consecutive in-hospital cardiac arrest patients ≥ 18 years. The cause of late death was based on data obtained from medical records, interviews with general practitioners or if available, autopsy reports. Deaths were classified according to a modified scheme for deaths used in antiarrhythmic trials. Results Between 1997 and 2004 a total of 222 in-hospital cardiac arrest patients underwent CPR and 42 (19%) patients survived to discharge. After a median follow-up of 2.9 years (IQR 1.5–7.2) 18 (43%) patients had died. There were 6 cardiac and 12 non-cardiac causes of death (table ). Of the cardiac causes 2 were arrhythmic and 4 non-arrhythmic. Amongst the 18 deceased patients 7 had ventricular fibrillation at the in-hospital cardiac arrest and thus an indication for an ICD. Of these patients one eventually had an arrhythmic cause of death. Conclusion In this study of patients discharged alive after in-hospital cardiac arrest 3-year survival was 60%. Surprisingly a late cause of death of cardiac origin was found in only a third of the patients and was mostly non-arrhythmic. Of the 7 patients with a current ICD-indication after the index event only one had a potentially preventable arrhythmic cause of late death. Validation of these findings in larger studies seems warranted.
Le Sang in Vitro: Éosinophilie—Fibrinogenèse—Phagocytose des Hématies.
Authors: Émile Liebreich
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biomarker Analysis in a Phase Ib Study Combining Ibrutinib with R-CHOP in Patients with CD20-Positive B-Cell Non-Hodgkin Lymphoma (NHL)
Authors: Shalini Chaturvedi, Michael Schaffer, Cuc Davis, Regina Aquino, Emily Stepanchick, Yasuhiro Oki, Nele Fourneau, Anas Younes, Sriram Balasubramanian
Journal: Blood (2014)
Man: His Making and Unmaking.
Authors: E. Boyd Barrett
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5496: Antiplatelet Effects and Bleeding Risk of DZ-697b, a Novel, Oral Antiplatelet Agent, versus Clopidogrel: Results of a Phase-I Study
Authors: Mohammad U Zafar, Borja Ibanéz, Brian G Choi, David A Vorchheimer, Antonio Pinéro, Peter M Vila, Walter S Speidl, Xioping Jin, Igor Sorokin, Raman K Sharma, Juan J Badimon
Journal: Circulation (2009)

INTRODUCTION : DZ-697b is a new orally active antiplatelet agent that inhibits collagen and ristocetin-mediated platelet aggregation. It does not require metabolization for the generation of its active compound and has a safer profile than clopidogrel in pre-clinical studies. The aim of this study was to investigate the platelet inhibitory effects and the bleeding risk of 3 doses of DZ-697b compared to 300mg clopidogrel. METHODS : In a 4-treatment, 3-period, crossover design, 20 healthy subjects (31±7 years, 85% male) were randomized to a single oral dose of DZ-697b 60mg, 120mg and 360mg, and clopidogrel 300mg (n=15 in each treatment). Antiplatelet effects were assessed by measuring changes from pre-dose to 6 hours post-dose in platelet-thrombus size at high- and low-flow rates in the Badimon chamber, and platelet adhesion at high- and low-shear rates using Diamed Impact-R platelet function assay. Bleeding risk was assessed using surgicutt bleeding time procedure, measured at predose and 6 hours postdose. RESULTS : DZ-697b caused dose-dependent reductions in thrombus size and platelet adhesion (Table ). Antiplatelet effects of DZ-697b 120mg were closest to clopidogrel 300mg. Bleeding times with all DZ-697b doses were significantly shorter than clopidogrel. CONCLUSIONS : The oral agent DZ-697b shows potent, dose-dependent, antiplatelet properties. Bleeding time prolongations with even the highest tested dose of DZ-697b is significantly shorter than 300mg clopidogrel. Further studies are warranted.
Chirurgie infantile d'urgence
Authors: Marcel Févre
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anti-LFA-1 blocking antibodies prevent the interleukin-8-induced mobilization of hematopoietic progenitor cells (HPC) in rhesus monkeys
Authors: J.F.M. Pruijt, C.G. Figdor, Y. van Kooyk, I.J.D. Lindley, R. Pieters, R. Willemze, W.E. Fibbe
Journal: Blood (1997)
Abstract 208: Deletion of the Circadian Rhythm Gene mPer2 is Cardioprotective
Authors: Jessica L Dries, Peter Easton, Amy Friesland, Jon DeAntonio, Vishnu Chintalgattu, Jian Ding, Robert Lust, Jitka Virag
Journal: Circulation (2007)

Variations in circadian patterns are evident in the incidence of cardiovascular disease and derangements in normal circadian patterns are demonstrated to precipitate the onset of chronic diseases. “Clock genes” such as Per-1 and -2, Cry-1 and -2, and clock/bmal , are found in all peripheral tissues, including the heart. It is clear that they are involved in synchronization of vascular function and cardiac metabolism however, the downstream effector genes have yet to be identified. To evaluate the function of mPer2 in post-infarct myocardial remodeling, we used an mPer2 mutant mouse which lacks functional mPer2 protein (mPer2-KO). In anesthetized, mechanically ventilated wild-type (WT) and mPer2-KO mice, Myocardial infarction was induced by permanent ligation of the left anterior descending coronary artery. Our data reveal that, although there is no difference in the initial area at risk between the WT and mPer2-KO mouse hearts, at 4 days post-MI there is a 50% reduction of infarct size in mPer2-KO mice compared to WT. This is coincident with a 40% increase in vascular density, 25% less macrophage infiltration, and 34% less apoptosis in the infarct zone. Cytokine array analysis showed 3-fold increase in IGFBP-3 and -5 and a 90% increase in SDF-1α, IL12p70, and lymphotactin in mPer2-KO relative to WT at 4 days post-MI. Conversely, in mPer2-KO the levels of L-selectin, sTNFRII, and IL-6 were approx. 70% less than the WT. These data suggest that mice lacking mPer2 protein have enhanced activation of anti-apoptotic and hypertrophic pathways, augmented chemotaxis for reparative cells, and blunted production of adverse inflammatory mediators post-MI. We conclude that deletion of the mPER2 gene is cardioprotective. Further mechanistic studies are being conducted to understand the signaling pathways that afford this protection. Long-term studies are also in progress to determine the duration of these protective effects and whether cardiac function is altered. Understanding the complex interactions between circadian rhythms and cardiovascular disease may provide insights into potential preventative and therapeutics for susceptible populations.
MacBryde's Signs and Symptoms: Applied Pathologic Physiology and Clinical Interpretation.
Authors: Cyril Mitchell MacBryde, Robert Stanley Blacklow
Journal: Annals of Internal Medicine (1985)

contributed to the previous (fifth) edition and a few to the fourth edition. The table of contents lists 40 sections, with headings such as Growth and Sex Development;  Tongue and Sore Mouth; Problems of Communication: Speech and Hearing, Ear Pain; Constipation and Diarrhea; and Hematemesis and Melena. Some of these sections are excellent. I was especially impressed with those dealing with jaundice, constipation and diarrhea, fever, and pathologic bleeding. Most of the remaining sections are adequate. Unfortunately, several of the sections should not be published in a textbook of medicine in the 1980s. I use that on coma and convulsions only as an example of the problems encountered in a few of the sections in this book. Dr O'Leary (now deceased) and Dr Landau wrote this section as they did the same section in the 1970 and the 1964 editions. Unfortunately, they changed very little in either the text
Allergic Rhinitis
Authors: Marshall Plaut, Martin D. Valentine
Journal: New England Journal of Medicine (2005)

A Baltimore college student has rhinorrhea, sneezing, nasal congestion, and itchy, watery eyes in the spring. He reports having had similar symptoms the previous spring. Over-the-counter allergy pills failed to help his symptoms and caused dry mouth and somnolence. He wants relief and assurance that he won't be ill, have dry mouth, or feel drowsy during final exams. On examination, his conjunctivae are injected, and his nasal mucous membranes are pale, wet, and boggy. What should the physician recommend?
Abstract 5082: Interferon-{gamma} Plays a Pivotal Role in Hypertension-Induced Cardiac Remodeling and Diastolic Heart Failure
Authors: Anthony G Garcia, Richard M Wilson, Joline Heo, Namita Murthy, Deepa S De Silva, Flora Sam
Journal: Circulation (2009)

Background: Diastolic heart failure (DHF) is clinical conundrum and accounts for ~50% of all HF admissions. There remains a paucity of therapies. Hypertension is the major cause of DHF and is associated with LV hypertrophy (LVH). Inflammatory cytokines are increased in hypertension but it is unknown if they mediate hypertension-induced cardiac remodeling. We tested the hypothesis that interferon-γ plays a pivotal role in the progression from hypertension-induced LVH to DHF. Methods: Twelve-week old BALB/c (WT) and interferon-γ deficient (IFNγKO) mice underwent either saline (saline; n=10) or aldosterone-infusion (ALDO; n=20). All underwent uninephrectomy and drank 1% salt water for 4-weeks. Four-weeks after surgery, tail-cuff blood pressure (BP), echocardiogram and gene/protein analyses were performed. Isolated adult rat ventricular myocytes (ARVM) were treated with either interferon-γ (500nM) and/or aldosterone (50nM) for 30min. Results: BP was increased in WT-ALDO vs. WT-saline mice (P<0.01). Interestin...
Efficacy of angiotensin-converting enzyme inhibitors and beta-blockers in the management of left ventricular systolic dysfunction according to race, gender, and diabetic status
Authors: Paul G. Shekelle, Michael W. Rich, Sally C. Morton, Col.Sid W. Atkinson, Wenli Tu, Margaret Maglione, Shannon Rhodes, Michael Barrett, Gregg C. Fonarow, Barry Greenberg, Paul A. Heidenreich, Tom Knabel, Marvin A. Konstam, Anthony Steimle, Lynne Warner Stevenson
Journal: Journal of the American College of Cardiology (2003)
Low use of neuroleptic drugs in the treatment of psychotic major depression
Authors: B H Mulsant, R F Haskett, J Prudic, M E Thase, K M Malone, J J Mann, H M Pettinati, H A Sackeim
Journal: American Journal of Psychiatry (1997)

Objective: The adequacy of pharmacologic treatment received by patients with psychotic major depression was evaluated.Method: The authors systematically assessed the pharmacotherapy received by 187 depressed patients before initiation of ECT and compared the medication trials of those with psychotic (N=53) and nonpsychotic (N=134) depression.Results: Despite a median of four medication trials and median index episode duration of 20 weeks, only two (4%) of the patients with psychotic depression received at least one adequate pharmacotherapy trial.In contrast, 70 (52%) of the patients with nonpsychotic depression received at least one adequate trial.Twenty-five (47%) of the patients with psychotic depression received either no neuroleptic treatment (N=11) or treatment for less than 3 weeks (N=14).Only eight (15%) received a daily neuroleptic dose higher than 200 mg of chlorpromazine equivalents.Conclusions: These findings suggest that many patients with psychotic major depression referred for ECT receive inadequate pharmacotherapy because of either the absence or the inadequate use of neuroleptic medication.