USE OF TRIMETHIDINIUM METHOSULFATE (A NEW GANGLIONIC BLOCKING AGENT) IN THE TREATMENT OF HYPERTENSION
Authors: N O BORHANI
Journal: Annals of Internal Medicine (1959)

Article1 November 1959USE OF TRIMETHIDINIUM METHOSULFATE (A NEW GANGLIONIC BLOCKING AGENT) IN THE TREATMENT OF HYPERTENSIONNEMAT O. BORHANI, M.D.NEMAT O. BORHANI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-5-983 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTrimethidinium methosulfate is an asymmetric bisquaternary amine, possessing ganglionic blocking properties but demonstrating, in addition, a central component of antihypertensive activity.1 The pharmacology of trimethidinium methosulfate has been studied by Klupp2 and by Eckfeld et al.,3 and its structural formula is shown in figure 1.The antihypertensive action of this compound has been studied by O'Malley et al. It has been claimed that trimethidinium methosulfate has "hypotensive potency in excess of any quaternized ganglioplegic agents presently in use."4Furthermore, it has been observed that the ganglionic blockade produced by trimethidinium methosulfate does not necessarily parallel its hypotensive effects. In an...Bibliography1. DunsmoreDunsmoreGoldmanEliasWarner RALDAMRS: Treatment of ambulatory hypertensive patients with trimethidinium methosulfate, Am. J. M. Sc. 236: 483, 1958. CrossrefMedlineGoogle Scholar2. Klupp H: Pharmacologic investigation of a new long-acting ganglionic blocking compound, Drug Research 7: 123, 1957. Google Scholar3. EckfeldTislowSeifter DKRJ: Hypotensive properties of some asymmetrical bisquaternary compounds, American Society for Pharmacology and Experimental Therapeutics, Baltimore, September, 4-7, 1957. Google Scholar4. O'MalleyHammerliRiceGeschickter WEGWLMCF: Studies on the antihypertensive action of N-dimethylaminopropyl-1-methyl-8, 8-dimethyl-3- azobicyclo (3,2,1) octane dimethochloride (WY-1395), J. Am. Pharm. A. 47: 263, 1958. CrossrefGoogle Scholar5. EckfeldTislowSeifter DKRJ: Hypotensive properties of some asymmetrical bisquaternary compounds, J. Pharmacol. and Exper. Therap. 122: 21A, 1958 (abstract). Google Scholar6. HoskoTownsendTislowSeifter MJPRJ: Hypotensive and ganglionic properties of d-N-dimethylamino-propyl-i-methyl-8, 8-dimethyl-3-azabicyclo [3,2,1] octane dimethosulfate, J. Pharmacol. and Exper. Therap. 122: 33A, 1958 (abstract). Google Scholar7. GrantBoyd APJS: Mecamylamine ileus as a surgical emergency, Lancet 1: 713, 1957. CrossrefGoogle Scholar8. Smirk FH: Results of methanium treatment of hypertensive patients, Brit. M. J. 1: 717, 1954. CrossrefMedlineGoogle Scholar9. SmirkMcQueen FHEG: Use of mecamylamine in the management of hypertension, Brit. M. J. 1: 422, 1957. CrossrefMedlineGoogle Scholar10. DoyleNeilson AEGH: Neuromuscular disorders in mecamylamine therapy, Brit. M. J. 2: 1431, 1956. CrossrefGoogle Scholar11. MoyerHeiderPerezFord JHCKRV: The effect of treatment on the vascular deterioration associated with hypertension, Am. J. Med. 24: 177, 1958. CrossrefMedlineGoogle Scholar12. LeeSeligmannClarckBorhani REAWMANO: Therapeutically refractory hypertension, Ann. Int. Med. 49: 1129, 1958. LinkGoogle Scholar13. SearsSnowHouston HTPJIB: Treatment of hypertension with pentolinium and mecamylamine, Brit. M. J. 1: 462, 1959. CrossrefMedlineGoogle Scholar14. KirkendallArmstrongFunkTheilen WMMLDCEO: Acute effects of trimethidinium methosulfate (WY 1395) on blood pressure, cardiac output, renal hemodynamics and pulse rate in man, Circulation 18 (Part II): 743, 1958. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication April 30, 1959.From the Hypertension Clinic, Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland.†Trimethidinium methosulfate (Ostensin, Wyeth), used in this study, was supplied by Wyeth Laboratories, Philadelphia, Pennsylvania.‡This study was supported in part by grant HT-5082 from the National Heart Institute, National Institutes of Health, U. S. Public Health Service.Requests for reprints should be addressed to Nemat O. Borhani, M.D., Hypertension Clinic, Department of Medicine, The Johns Hopkins Hospital, Baltimore 5, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuaternary Ammonium Compounds in Medicinal Chemistry, IIGANGLION STIMULANTS AND BLOCKING DRUGS 1 November 1959Volume 51, Issue 5Page: 983-992KeywordsHospital medicineHypertensionMedical servicesOral administrationParalysisPharmacologyPrevention, policy, and public healthRespirationUreaVision ePublished: 1 December 2008 Issue Published: 1 November 1959 PDF downloadLoading ...