Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: a randomised, controlled, phase 2 trial
Authors: Katherine R Tuttle, Sibylle J Hauske, Maria Eugenia Canziani, Maria Luiza Caramori, David Cherney, Lisa Cronin, Hiddo J L Heerspink, Christian Hugo, Masaomi Nangaku, Ricardo Correa Rotter, Arnold Silva, Shimoli V Shah, Zhichao Sun, Dorothea Urbach, Dick de Zeeuw, Peter Rossing, Katherine R Tuttle, Sibylle J Hauske, Maria Eugenia Canziani, Maria Luiza Caramori, David Cherney, Lisa Cronin, Hiddo J L Heerspink, Christian Hugo, Masaomi Nangaku, Ricardo Correa Rotter, Arnold Silva, Shimoli V Shah, Zhichao Sun, Dorothea Urbach, Dick de Zeeuw, Peter Rossing, Cheuk Chun SZETO, Diego Echeverri, Edouard Martin, Ming Li Yee, William Wah, Ray Wang, Bobby Chacko, Shriram Swaminathan, Richard MacIsaac, Hikaru Hashimura, Glenn Ward, Katrien De Vusser, Kathleen Claes, Dirk Kuypers, Björn Meijers, Amaryllis Van Craenenbroeck, Robert Hilbrands, Corinne Debroye, Karl Martin Wissing, Michel Jadoul, Nathalie Demoulin, Serge Treille De Grandsaigne, Ishak Beklevic, Diane Marcoux, Fabienne Liénart, Claude Daper, Véronique De Brouckere, Mercédès Heureux, Joao Felicio, Karem Mileo Felicio, Daniella Leite, Franciane Melo, Natercia Queiroz, Ana Carolina Souza, Jocyelle Vieira, Roberto Franco, Adriana Mendes, Giovana Picolli, Luis Henrique Canani, Carla Sartori, Adriana Valenti, Freddy Eliaschewitz, Renata Bona, Denise Franco, Denise Ludovico Costa de Castro, Vanessa Magalhaes, Marcelo Oliveira, Célia Regina Sampaio, Guilherme Visconti, Bruno Halpern, Camila Nihei, Bruna Pessoa, Carlos Seraphim, Daniel Santos, Claudia Brito, Joao Douverny, Marina Colella, Cristina Gazeta, Monique Vercia, Renato Watanabe, Theodora Temelkova, Dimo Kjurkchiev, Silviya Statkova, Iliya Popov, Radosveta Radeva, Lachezar Arabadzhiev, Mariya Binova, Aleksandar Bosilkov, Neli Koleva-Stoicheva, Ivaylo Ivanov, Zornitsa Ivanova, Viktoria Kotseva, Petar Spasov, Ivaylo Tsvetkov, Shivinder Jolly, Gordon Bailey, Zhiming Ye, Jianying Niu, Hongmei Li, Qing Wu, Bing Liao, Chuanming Hao, Lingyun Lai, Yunyu Xu, Min Zhang, Yiwen Li, Bo Liu, Lina Shao, Wei Chen, Haishan Wu, Marian Pirchala, Iva Skarpova, Marketa Hraskova, Simoneta Soukupova, Lucie Veberova, Tomas Drasnar, Matej Falc, Blazej Racz, Stepan Votocek, Danica Weissova, Lenka Syc-Krivanova, Dagmar Slezak, Ilkka Kantola, Sakari Nieminen, Milla Anttonen, Jyrki Taurio, Jorma Lahtela, Vasileios Tsimihodimos, Olga Balafa, Evangelia Dounousi, Sissy Sakkou, Nikolaos Tentolouris, Christos Siafarikas, Evangelia Siami, Ioannis Doupis, Theodoros Angelopoulos, Christodoulos Georgoulias, Denes Pall, Regina Esze, Tamas Kobling, Zita Varadi, Noemi Zsiros, Viktor Vass, Timea Balo, Erika Csanyi, Ivan Ory, Istvan Pall, Valentina Patai, Zsuzsanna Zeak, Istvan Takacs, Akos Petho, Balazs Szili, Laszlo Koranyi, Katalin Bezzegh, Jozsef Pauer, Eva Peterfai, Laszlo Konyves, Brigitta Szoke, Csaba Hajdu, Krisztina Kalman, Raj Yadav, Navneet Saxena, Meenakshi Bhattacharya, Bal Sharma, Nihal Thomas, Felix Jebasingh K, Nitin Kapoor, Mathews E. Kurian, Jinson Paul, Priyadharshini Ramesh, Sheeba Varghese, Nobuyuki Shibusawa, Hiroshi Nishi, Nobuyasu Noritake, Takashi Oda, Hideki Okamoto, Hirotake Kasuga, Hiroshi Hori, Yukiko Ito, Toshihiro Mizukoshi, Hideto Ishii, Seung Hyeok Han, Hyung Woo Kim, Kook-Hwan Oh, Seung Seok Han, Sang Youb Han, Dae Ryong Cha, Jin Joo Cha, Soon-Kil Kwon, Hyunjeong Cho, Hye-Young Kim, Sun Moon Kim, Jung Pyo Lee, Jeonghwan Lee, Li Yuan Lee, Meng Lee Chang, Shian Tuck Laang, Zhao Zhi Tan, Hajar Ahmad Rosdi, Siti Hafizah Mohammad Ismail, Devamalar Simatherai, Ju Fan Tay, Eddie, Fook Sem Wong, Suryati Yakob, Noorhafini Abdul Sukur, Amalina Anuar, Syaliza Md. Rasid, Irma Liyana Mushaddik, Ruslinda Mustafar, Muhammad Yusuf Abu Shamsi, Voon Ken Fong, Lydia Kamaruzaman, Rozita Mohd, Wan Rohaslizan Wan Daud, Wan Hasnul Halimi Wan Hassan, Suhaidarwani Ab Hamid, Muhammad Nabil Abdullah, Mohd Yusran Yusoff, G R Letchuman Ramanathan, Kim Yen Lee, Wan Fadhilah Wan Ismail, Enrique Morales Villegas, Rubria Ramirez Baez, Jorge Vital Lopez, Cristhian Arias Delgadillo, Marisol Herrera Marmolejo, Rosa Parra Perez, Melchor Alpizar Salazar, Ana Flores Montealegre, Jose Galvan Magaña, Minerva Gutierrez Tlapale, Daniela Reyes Munguia, Bartlomiej Witczak, Lasse Gøransson, Inga Strand Thorsen, Clodoaido Caringal, Mario Villardo, Ronaldo Toledo, Emerlinda Fausto Dijamco, Norman Cornelio De Asis, Angelica Kuizon, Elizabeth Ann Catindig, Ronald Perez, Grace Aquitania, Jimrie David Pableo, Jay Karlou Sanchez, Ewa Czernecka, Aleksandra Cegiel, Dorota Knychas, Malgorzata Ochnio, Monika Kuligowska-Jakubowska, Marek Cesarz, Milena Kowalewska-Celejewska, Anna Masajtis-Zagajewska, Lukasz Jankowski, Marcin Ojrzanowski, Magdalena Olszewska-Jander, Ewa Skokowska, Malgorzata Giermakowska-Samek, Elzbieta Luchowska, Renata Patkowska, Marzenna Sekulska, Dorota Marczuk-Krynicka, Andrzej Marciniak, Michal Barwijuk, Marcin Myslicki, Michal Siek, Danuta Wronska, Jadwiga Tomsia-Goncerz, Krzysztof Wronski, Roman Junik, Szymon Dzialak, Ewelina Kurlapska, Wieslaw Malecha, Szymon Suwala, Patrícia Branco, Rita Birne, João Raposo, Marta Ferreira, Henrique Alexandrino, Helena Alves, Sara Correia, Maria João Oliveira, Diogo Ramalho, Patricia Tavares, Kathleen Coetzee, Sue Blignaut, Winifred Viljoen, Elsje Potgieter, Elmien Malherbe, Alberto Ortiz Arduán, Elena Goma Garcés, María Pérez, Rafael Santamaría, Isabel López López, Victoria Pendón de Mier, Cristian Rodelo Haad, María Marques, Esther Domènech, Josep Maria Portoles, María José Soler, Irene Agraz, María Antonieta Azancot, Sheila Bermejo, Mónica Bolufer, Marina López, Natalia Ramos, Néstor Toapanta, Secundino Cigarrán Guldris, Juan Carlos Primo, Luis Enrique Pérez, María Rebollido Fernández, Helene Holmer, Annette Bruchfeld, Justus Rofors, Bengt-Olov Tengmark, Gregoire Wuerzner, Garazi Leanizbarrutia, Savas Ozturk, Nurana Guler, Seda Safak, Keung Lee, Stephen Campbell, Imran Siddiqui, Nadia Abbasi, Faiza Tahir, Masoud Azizad, Timothy Jackson, Brian Everhart, Michael Oliver, William Rust, Matthew Sniezek, Ahmed Arif, Mohammed Syed, Nitin Bhasin, Michael Bien, Claudio Gallego, Aamir Jamal, Mojtaba Moghadam, Abid Rizvi, Amna Rizvi, Syed Rizvi, Christopher Wong, Kathryn Lucas, Andrea Buery, Ku-Lang Chang, Claire Presswood, Justin Smith, Ankur Doshi, Manish Parikh, Jeannine Wallace, Arvind Krishna, Heidi Daugherty, Aaron Fearday, Christopher Keller, Jerry Meng, Alexandra Nielsen, Sergio Rovner, Javier Almeida, Benito Marranzini, Lisa Selby, Zachary Yablon, Daphne Jean-Louis, Wayne Kotzker, Chabely Perez, Marc Richards, Reinaldo Rosario, Roy Marcus, Chike Okechukwu, Dennis Ross, Rachel Gromala, Matthew Reed, Lisa Weber, Imran Nazeer, Prashant Kumar, Muhammad Mir, Heidi Shea, Amanda Hart, Jaime Wiebel, Laura Kooienga, Britt Newsome, Irina Suyumova, German Alvarez, Venkata Bireddy, Maria Lansang, Jose Mandry, Maria Freire, Oscarina Herrera Albornoz, Anant Desai, Dayan Gandhi, Sibu Rajan, Louis Raymond, Jorge Posada, Luis Garcia-Mayol, Rodolfo Gutierrez-Alsina, Juan Fernandez, Kendaling Bruce, Juan Cuellar, Maria Ranz y Alvarez, Ines Bartolacci, Mauro Pautasso, Daniela Stoppa, Miguel Riella, Maria Barbosa, Eleonora Harcsa, Yuvraj Gulati, Denish Savalia, Prakash Khetan, Dhananjay Sinha, Niranjan R, Srinivas K, Fabiola Pazos, Aretha Gacutan-Liwag, Malgorzata Duszynska, Karolina Antkowiak-Piatyszek, Grzegorz Konieczny, Anna Sidorowicz-Bialynicka, Agnieszka Ciesiolkiewicz-Wojcik, Marek Dwojak, Katarzyna Szymkowiak, Daria Gorczyca-Siudak, Marzena Janik-Palazzolo, Lukasz Siudak, Jaroslaw Opiela, Dariusz Iwanow, Monika Solkiewicz, Malgorzata Sipinska-Surzynska, Magdalena Olszanecka - Glinianowicz, Izabela Rozmilowska, Julian Trokis, Hans Prozesky, Lesley Burgess, Henry Cyster, Jurie Jordaan, Hawa Mohamed, Christina Naude, Thembie Sitsila, Arvind Mehta, Bharat Mocherla, Sungchun Lee, Kenneth Boren, Lance Rudolph, Sabrina Benjamin, Danny Sugimoto, Jamal Hammoud, Muhammad Bakleh, Yaseen Hashish, Jonathan Da Costa, Marina Gold, Claudio Majul, Juan Buscema, Maria Gatto, Facundo Lombardi, Olga Paez, Pablo Puleio, Andrés Alvarisqueta, Vanessa Pajon, Gabriel Suarez, Adrian Hernandez Gauna, Alejandro Pereyra, Moira Reig, Elizabeth Gelersztein, Gina Campestri, Maria Gonzalez Santos, Julieta Sambresqui, Gustavo Catalano, Cecilia Igarzabal, Augusto Vallejos, Claudio Escobari, Rocio Marchetto, Mariano Chahin, Andrea Aguilera, Ana Comes, Silvia Rodriguez Segade, Claudia Baccaro, María Verónica Larrieu Lacoste, Ruben Saurral, Alberto Cristino, Dario Dran, Martin Koretzky, Juan Ponti, Alejandro Porto, Yasmin Tenaglia, Natacha Maldonado, Natalia Bertollo, Verónica Van Perdeck, Kai Lopau, Christoph Wanner, Florieke Berfelo, Christel Contzen, Abdulwahab Arbi, Young Hee Lee-Barkey, Aleksandra Maciejewska, Katrin Arelin, Hermann Haller, Jessica Kaufeld, Kai Schmidt-Ott, Sven Heinrichs, Thilo Krüger, Chris Gebauer, Alexander Paliege, Elena Henkel, Christoph Axthelm, Karl-Michael Derwahl, Roberto Trevisan, Rosalia Bellante, Nicolò Borrella, Anna Corsi, Loreto Gesualdo, Teodora Ardillo, Maria Ficarella, Sameh Fikry, Giuseppe Mazza, Lysane Poirier, Harpreet Bajaj, Erifili Hatziagelaki, Sokratis Katopodis, Spiros Katsoudas, Shuichi Yamaura, Tsutomu Shikano, Takahiro Tosaki, Otoya Miho, Naoki Tachibana, Wataru Yumita, Hiroshi Kado, Jesus Villarreal Martinez, Ernesto Soto Miranda, David Gonzalez Rodriguez, Araceli Panelo, Telma Santos, Rita Birne, Patrícia Branco, Ana Martins, Catarina Mateus, Fernando Teixeira e Costa, Sara Barreto, Joana Silva Costa, Francisco Ferrer, Joana Silva, Ahmed Awad, Shatha Khaleel, Ryan Lustig, Gajendra Maharjan, Jaynier Moya, Amit Johnsingh, Idalia Acosta, George Newman, Anita Buckle, Kendra Hendon
Journal: The Lancet (2023)