tbuckley/cabot-search huggingface dataset:
Correction: Pan-intestinal capsule endoscopy as first-line procedure in patients with suspected mid or lower gastrointestinal bleeding
Authors: Bruno Rosa, Tiago Cúrdia Gonçalves, Maria J. Moreira, Francisca Dias de Castro, Bernardo Sousa-Pinto, Mário Dinis-Ribeiro, José Cotter
Journal: Endoscopy (2024)

Correction to: Pan-intestinal capsule endoscopy as first-line procedure in patients with suspected mid or lower gastrointestinal bleedingEndoscopy eFirstDOI: 10.1055/a-2270-4601
Disrupting glycolysis and DNA repair in anaplastic thyroid cancer with nucleus-targeting platinum nanoclusters
Authors: Zongfu Pan, Xixuan Lu, Xi Hu, Ruixi Yu, Yulu Che, Jie Wang, Lin Xiao, Jianqiang Chen, Xiaofen Yi, Zhuo Tan, Fangyuan Li, Daishun Ling, Ping Huang, Minghua Ge
Journal: Journal of Controlled Release (2024)
Noninvasive Techniques for Tracking Biological Aging of the Cardiovascular System
Authors: Zahra Raisi-Estabragh, Liliana Szabo, Art Schuermans, Ahmed M. Salih, Calvin W.L. Chin, Hajnalka Vágó, Andre Altmann, Fu Siong Ng, Pankaj Garg, Sofia Pavanello, Thomas H. Marwick, Steffen E. Petersen
Journal: JACC. Cardiovascular imaging (2024)

Population aging is one of the most important demographic transformations of our time. Increasing the "health span"—the proportion of life spent in good health—is a global priority. Biological aging comprises molecular and cellular modifications over many years, which culminate in gradual physiological decline across multiple organ systems and predispose to age-related illnesses. Cardiovascular disease is a major cause of ill health and premature death in older people. The rate at which biological aging occurs varies across individuals of the same age and is influenced by a wide range of genetic and environmental exposures. The authors review the hallmarks of biological cardiovascular aging and their capture using imaging and other noninvasive techniques and examine how this information may be used to understand aging trajectories, with the aim of guiding individual- and population-level interventions to promote healthy aging.
A Brief Intervention With Instant Messaging or Regular Text Messaging Support in Reducing Alcohol Use
Authors: Siu Long Chau, Tzu Tsun Luk, Benney Yiu Cheong Wong, Yongda Socrates Wu, Yee Tak Derek Cheung, Sai Yin Ho, Jean H. Kim, Herman Hay Ming Lo, Tai Hing Lam, Man Ping Wang
Journal: JAMA Internal Medicine (2024)

Alcohol use is prevalent among university students. Mobile instant messaging apps could enhance the effectiveness of an alcohol brief intervention (ABI), but the evidence is scarce.
Successful cannulation using a novel rotatable sphincterotome in a hepaticojejunal anastomotic stricture with a steep angle
Authors: Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Takahiro Shin, Kei Sugimoto, Ryuhei Jinushi, Shomei Ryozawa
Journal: Endoscopy (2024)

Balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography (ERCP) is useful in patients with a hepaticojejunal anastomotic stricture [1] [2] [3]. However, biliary cannulation for such a stricture is challenging especially in cases with a steep angle, because the balloon enteroscope has no elevator function to angulate the cannulation catheter. We report a case of successful cannulation using a novel rotatable sphincterotome in a patient with a hepaticojejunal anastomotic stricture at a steep angle.
Stiffness Mediated‐Mechanosensation of Airway Smooth Muscle Cells on Linear Stiffness Gradient Hydrogels
Authors: Yong Hwee Tan, Kimberley C. W. Wang, Ian L. Chin, Rowan W. Sanderson, Jiayue Li, Brendan F. Kennedy, Peter B. Noble, Yu Suk Choi
Journal: Advanced Healthcare Materials (2024)

In obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), the extracellular matrix (ECM) protein amount and composition of the airway smooth muscle (ASM) is often remodelled, likely altering tissue stiffness. The underlying mechanism of how human ASM cell (hASMC) mechanosenses the aberrant microenvironment is not well understood. Physiological stiffnesses of the ASM were measured by uniaxial compression tester using porcine ASM layers under 0, 5 and 10% longitudinal stretch above in situ length. Linear stiffness gradient hydrogels (230 kPa range) were fabricated and functionalized with ECM proteins, collagen I (ColI), fibronectin (Fn) and laminin (Ln), to recapitulate the above-measured range of stiffnesses. Overall, hASMC mechanosensation exhibited a clear correlation with the underlying hydrogel stiffness. Cell size, nuclear size and contractile marker alpha-smooth muscle actin (αSMA) expression showed a strong correlation to substrate stiffness. Mechanosensation, assessed by Lamin-A intensity and nuc/cyto YAP, exhibited stiffness-mediated behaviour only on ColI and Fn-coated hydrogels. Inhibition studies using blebbistatin or Y27632 attenuated most mechanotransduction-derived cell morphological responses, αSMA and Lamin-A expression and nuc/cyto YAP (blebbistatin only). This study highlights the interplay and complexities between stiffness and ECM protein type on hASMC mechanosensation, relevant to airway remodelling in obstructive airway diseases.
Impedance planimetry-guided peroral endoscopic myotomy of the fundoplication valve
Authors: Sandra Nagl, Alanna Ebigbo, Marc Barthet, Helmut Messmann
Journal: Endoscopy (2024)

We present a novel approach involving impedance planimetry with the endoscopic functional lumen imaging probe (EndoFLIP) to guide peroral endoscopic myotomy of the fundoplication valve (FP-POEM) ([Video 1]).
Usefulness of a novel drill dilator in removing a migrated biliary plastic internal stent
Authors: Takafumi Yanaidani, Tomoaki Matsumori, Masataka Yokode, Yuya Muramoto, Masahiro Shiokawa, Norimitsu Uza, Hiroshi Seno
Journal: Endoscopy (2024)

A 45-year-old woman referred to hospital for preoperative evaluation of perihilar cholangiocarcinoma ([Fig. 1]) had multiple biliary plastic internal stents placed previously ([Fig. 2] a). Endoscopic retrograde cholangiography (ERC) was performed to evaluate tumor extent and replace the plastic internal stents. ERC revealed that a nylon-threaded plastic stent (Through & Pass, 7 Fr, 9 cm; Gadelius Medical, Tokyo, Japan) placed in the left hepatic duct (B2) had migrated into the peripheral bile duct ([Fig. 2] b). The nylon threads had entered the common bile duct and the migrated plastic stent could not be removed by pulling them.
Future policy and research for advance care planning in dementia: consensus recommendations from an international Delphi panel of the European Association for Palliative Care
Authors: Miharu Nakanishi, Sandra Martins Pereira, Lieve Van den Block, Deborah Parker, Karen Harrison-Dening, Paola Di Giulio, Jürgen In der Schmitten, Philip J Larkin, Ninoslav Mimica, Rebecca L Sudore, Iva Holmerová, Ida J Korfage, Jenny T van der Steen
Journal: The Lancet Healthy Longevity (2024)

Advance care planning (ACP) is increasingly recognised in the global agenda for dementia care. The European Association for Palliative Care (EAPC) Taskforce on ACP in Dementia aimed to provide recommendations for policy initiatives and future research. We conducted a four-round Delphi study with a 33-country panel of 107 experts between September, 2021, and June, 2022, that was approved by the EAPC Board. Consensus was achieved on 11 recommendations concerning the regulation of advance directives, equity of access, and dementia-inclusive approaches and conversations to express patients' values. Identified research gaps included the need for an evidence-based dementia-specific practice model that optimises engagement and communication with people with fluctuating and impaired capacity and their families to support decision making, while also empowering people to adjust their decisions if their goals or preferences change over time. Policy gaps included insufficient health services frameworks for dementia-inclusive practice. The results highlight the need for more evidence and policy development that support inclusive ACP practice models.
Cabozantinib in patients with unresectable and progressive metastatic phaeochromocytoma or paraganglioma (the Natalie Trial): a single-arm, phase 2 trial
Authors: Camilo Jimenez, Mouhammed Amir Habra, Matthew T Campbell, Gina Tamsen, Damaris Cruz-Goldberg, James Long, Roland Bassett, Robert Dantzer, Vania Balderrama-Brondani, Jeena Varghese, Yang Lu
Journal: The Lancet Oncology (2024)
Laser lithotripsy for pancreatolithiasis in pancreas divisum
Authors: Rohit Gupta, Sugata Narayan Biswas
Journal: Endoscopy (2024)

Pancreas divisum is the most common congenital anomaly of the pancreas with a reported prevalence of 6%–10% [1] [2]. Pancreas divisum may predispose to recurrent acute pancreatitis and its complications, and eventually may result in chronic pancreatitis in a subset of patients. In the setting of chronic pancreatitis due to pancreas divisum, therapeutic intervention in the form of minor papilla sphincterotomy, balloon dilation of the papillary orifice, and transpapillary dorsal duct stenting may be indicated in patients with abdominal pain refractory to medical therapy, presence of stones or stricture, and/or a dilated dorsal pancreatic duct. Laser lithotripsy in the management of pancreatolithiasis in patients with pancreas divisum has been rarely reported [3].
The conceptual foundations of innate immunity: Taking stock 30 years later
Authors: Thomas Pradeu, Bart P.H.J. Thomma, Stephen E. Girardin, Bruno Lemaitre
Journal: Immunity (2024)

SummaryWhile largely neglected over decades during which adaptive immunity captured most of the attention, innate immune mechanisms have now become central to our understanding of immunology. Innate immunity provides the first barrier to infection in vertebrates, and it is the sole mechanism of host defense in invertebrates and plants. Innate immunity also plays a critical role in maintaining homeostasis, shaping the microbiota, and in disease contexts such as cancer, neurodegeneration, metabolic syndromes, and aging. The emergence of the field of innate immunity has led to an expanded view of the immune system, which is no longer restricted to vertebrates and instead concerns all metazoans, plants, and even prokaryotes. The study of innate immunity has given rise to new concepts and language. Here, we review the history and definition of the core concepts of innate immunity, discussing their value and fruitfulness in the long run.
Integrating research on bacterial pathogens and commensals to fight infections—an ecological perspective
Authors: Lisa Maier, Christoph Stein-Thoeringer, Ruth E Ley, Heike Brötz-Oesterhelt, Hannes Link, Nadine Ziemert, Samuel Wagner, Andreas Peschel
Journal: The Lancet Microbe (2024)

The incidence of antibiotic-resistant bacterial infections is increasing, and development of new antibiotics has been deprioritised by the pharmaceutical industry. Interdisciplinary research approaches, based on the ecological principles of bacterial fitness, competition, and transmission, could open new avenues to combat antibiotic-resistant infections. Many facultative bacterial pathogens use human mucosal surfaces as their major reservoirs and induce infectious diseases to aid their lateral transmission to new host organisms under some pathological states of the microbiome and host. Beneficial bacterial commensals can outcompete specific pathogens, thereby lowering the capacity of the pathogens to spread and cause serious infections. Despite the clinical relevance, however, the understanding of commensal–pathogen interactions in their natural habitats remains poor. In this Personal View, we highlight directions to intensify research on the interactions between bacterial pathogens and commensals in the context of human microbiomes and host biology that can lead to the development of innovative and sustainable ways of preventing and treating infectious diseases.
The WHO fungal priority pathogens list: a crucial reappraisal to review the prioritisation
Authors: Giacomo Casalini, Andrea Giacomelli, Spinello Antinori
Journal: The Lancet Microbe (2024)

In October, 2022, WHO published the first fungal priority pathogen list, which categorised 19 fungal entities into three priority groups (critical, high, and medium), for prioritisation of research efforts. The final ranking was determined via multiple criteria decision analysis, considering both research and development needs and perceived public health importance. In this Personal View, we discuss the positioning of the fungal pathogens, namely, Mucorales, Candida spp, Histoplasma spp, Coccidioides and Paracoccidioides spp, Fusarium spp, eumycetoma causative agents, Talaromyces marneffei, and Pneumocystis jirovecii, while expressing concerns about potential disparities between the WHO fungal priority pathogen list ranking and the actual disease burden associated with these pathogens. Finally, we propose a revised prioritisation list that also considers the regional disparities in the burden of fungal diseases.
Cryosim-1: a cool solution for acute and chronic itch
Authors: Darya Pavlenko, Tasuku Akiyama
Journal: British Journal of Dermatology (2024)

Journal Article Corrected proof Cryosim-1: a cool solution for acute and chronic itch Get access Darya Pavlenko, Darya Pavlenko Writing - original draft Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA https://orcid.org/0000-0001-7070-7421 Search for other works by this author on: Oxford Academic Google Scholar Tasuku Akiyama Tasuku Akiyama Writing - review & editing Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA Correspondence: Tasuku Akiyama. Email: takiyama@miami.edu https://orcid.org/0000-0001-7155-4228 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, ljae102, https://doi.org/10.1093/bjd/ljae102 Published: 09 April 2024 Article history Received: 04 March 2024 Accepted: 07 March 2024 Corrected and typeset: 09 April 2024 Published: 09 April 2024
Neoadjuvant Chemotherapy and Immunotherapy for Estrogen Receptor–Positive Human Epidermal Growth Factor 2–Negative Breast Cancer
Authors: Alejandro Ríos-Hoyo, Erin Cobain, Laura A. Huppert, Peter D. Beitsch, Thomas A. Buchholz, Laura Esserman, Laura J. van 't Veer, Hope S. Rugo, Lajos Pusztai
Journal: Journal of Clinical Oncology (2024)
Reply to Giancarlo Marra, Marco Oderda, Paolo Gontero, and Lorenzo Richiardi’s Letter to the Editor re: Jim C. Hu, Melissa Assel, Mohamad E. Allaf, et al. Transrectal Magnetic Resonance Imaging–targeted and Systematic Prostate Biopsy to Prevent Infectious Complications: The PREVENT Randomized Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2023.12.015
Authors: Jim C. Hu, Mohamad E. Allaf, Andrew J. Vickers, Edward M. Schaeffer
Journal: European Urology (2024)
Rise in First-Time ERCP for Benign Indications &gt;1 Year After Cholecystectomy Is Associated With Worse Outcomes
Authors: Nikhil R Thiruvengadam, Monica Saumoy, Douglas E Schaubel, Peter B Cotton, B Joseph Elmunzer, Martin L Freeman, Shyam Varadarajulu, Michael L Kochman, Gregory A Coté
Journal: Clinical Gastroenterology and Hepatology (2024)

Greater availability of less invasive biliary imaging to rule out choledocholithiasis should reduce the need for diagnostic endoscopic retrograde cholangiopancreatography (ERCP) in patients who have a remote history of cholecystectomy. The primary aims were to determine the incidence, characteristics, and outcomes of individuals who undergo first-time ERCP >1 year after cholecystectomy (late-ERCP).
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Authors: Jingjing Jiang, Lingyan Jiang, Benjamin J. Maldonato, Yingyun Wang, Matthew Holderfield, Ida Aronchik, Ian P. Winters, Zeena Salman, Cristina Blaj, Marie Menard, Jens Brodbeck, Zhe Chen, Xing Wei, Michael J. Rosen, Yevgeniy Gindin, Bianca J. Lee, James W. Evans, Stephanie Chang, Zhican Wang, Kyle J. Seamon, Dylan Parsons, James Cregg, Abby Marquez, Aidan C.A. Tomlinson, Jason K. Yano, John E. Knox, Elsa Quintana, Andrew J. Aguirre, Kathryn C. Arbour, Abby Reed, W. Clay Gustafson, Adrian L. Gill, Elena S. Koltun, David Wildes, Jacqueline A.M. Smith, Zhengping Wang, Mallika Singh
Journal: Cancer Discovery (2024)

Abstract RAS-driven cancers comprise up to 30% of human cancers. RMC-6236 is a RAS(ON) multi-selective noncovalent inhibitor of the active, GTP-bound state of both mutant and wild-type variants of canonical RAS isoforms with broad therapeutic potential for the aforementioned unmet medical need. RMC-6236 exhibited potent anticancer activity across RAS-addicted cell lines, particularly those harboring mutations at codon 12 of KRAS. Notably, oral administration of RMC-6236 was tolerated in vivo and drove profound tumor regressions across multiple tumor types in a mouse clinical trial with KRASG12X xenograft models. Translational PK/efficacy and PK/PD modeling predicted that daily doses of 100 mg and 300 mg would achieve tumor control and objective responses, respectively, in patients with RAS-driven tumors. Consistent with this, we describe here objective responses in two patients (at 300 mg daily) with advanced KRASG12X lung and pancreatic adenocarcinoma, respectively, demonstrating the initial activity of RMC-6236 in an ongoing phase I/Ib clinical trial (NCT05379985). Significance: The discovery of RMC-6236 enables the first-ever therapeutic evaluation of targeted and concurrent inhibition of canonical mutant and wild-type RAS-GTP in RAS-driven cancers. We demonstrate that broad-spectrum RAS-GTP inhibition is tolerable at exposures that induce profound tumor regressions in preclinical models of, and in patients with, such tumors. This article is featured in Selected Articles from This Issue, p. 897
Engineering Wet‐Resistant and Osteogenic Nanocomposite Adhesive to Control Bleeding and Infection after Median Sternotomy
Authors: Mahshid Shokri, Mahshid Kharaziha, Hossein Ahmadi Tafti, Faezeh Dalili, Rouhollah Mehdinavaz Aghdam, Mohamadreza Baghaban Eslaminejad
Journal: Advanced Healthcare Materials (2024)

Abstract Median sternotomy surgery stands as one of the prevailing strategies in cardiac surgery. In this study, the cutting‐edge bone adhesive is designed, inspired by the impressive adhesive properties found in mussels and sandcastle worms. This work has created an osteogenic nanocomposite coacervate adhesive by integrating a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, and zinc, gallium‐doped hydroxyapatite nanoparticles. This adhesive is characterized by robust catechol–metal coordination which effectively adheres to both hard and soft tissues with a maximum adhesive strength of 900 ± 38 kPa on the sheep sternum bone, surpassing that of commercial bone adhesives. The release of zinc and gallium cations from nanocomposite adhesives and quaternized chitosan matrix imparts remarkable antibacterial properties and promotes rapid blood coagulation, in vitro and ex vivo. It is also proved that this nanocomposite adhesive exhibits significant in vitro bioactivity, stable degradability, biocompatibility, and osteogenic ability. Furthermore, the capacity of nanocomposite coacervate to adhere to bone tissue and support osteogenesis contributes to the successful healing of a sternum bone defect in a rabbit model in vivo. In summary, these nanocomposite coacervate adhesives with promising characteristics are expected to provide solutions to clinical issues faced during median sternotomy surgery.
Preclinical Efficacy of a PSMA-Targeted Actinium-225 Conjugate (225Ac-Macropa-Pelgifatamab): A Targeted Alpha Therapy for Prostate Cancer
Authors: Christoph A. Schatz, Sabine Zitzmann-Kolbe, Ingrid Moen, Monika Klotz, Shankari Nair, Stefan Stargard, Roger M. Bjerke, Katrine Wickstrøm Biseth, Yuan Zeng Feng, Bård Indrevoll, Veronique Cruciani, Jenny Karlsson, Bernard Haendler, Carsten H. Nielsen, Maria Z. Alfsen, Stefanie Hammer, Hartwig Hennekes, Alan Cuthbertson, Urs B. Hagemann, Åsmund Larsen
Journal: Clinical Cancer Research (2024)

Initially, prostate cancer responds to hormone therapy, but eventually resistance develops. Beta emitter-based prostate-specific membrane antigen (PSMA)-targeted radionuclide therapy is approved for the treatment of metastatic castration-resistant prostate cancer. Here we introduce a targeted alpha therapy (TAT) consisting of the PSMA antibody pelgifatamab covalently linked to a macropa chelator and labeled with actinium-225 and compare its efficacy and tolerability with other TATs.
Janus kinase inhibitors and tumour necrosis factor inhibitors show a favourable safety profile and similar persistence in rheumatoid arthritis, psoriatic arthritis and spondyloarthritis: real-world data from the BIOBADASER registry
Authors: Blanca Hernández-Cruz, Lucía Otero-Varela, Mercedes Freire-González, Noemí Busquets-Pérez, Alfredo Javier García González, Manuel Moreno-Ramos, Juan Maria Blanco-Madrigal, Sara Manrique-Arija, Eva Perez-Pampin, Dolores Ruiz-Montesino, Fernando Sánchez-Alonso, Carlos Sanchez-Piedra, Isabel Castrejón
Journal: Annals of the Rheumatic Diseases (2024)

To compare the safety of Janus kinase inhibitors (JAKi) with that of tumour necrosis factor inhibitors (TNFi) and determine drug persistence among patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA).
Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis
Authors: Ji-Won Kim, Jun Sik Yoon, Sojeong Park, Hasung Kim, Ji Sung Lee, Jung-Yoon Choe
Journal: Annals of the Rheumatic Diseases (2024)

Objective To investigate the risk of cardiovascular disease (CVD) associated with increasing dose of a non-steroidal anti-inflammatory drug (NSAID) in patients with ankylosing spondylitis (AS). Methods Using the Korean National Health Insurance database, patients newly diagnosed with AS without prior CVD between 2010 and 2018 were included in this nationwide cohort study. The primary outcome was CVD, a composite outcome of ischaemic heart disease, stroke or congestive heart failure. Exposure to NSAIDs was evaluated using a time-varying approach. The dose of NSAIDs was considered in each exposure period. Cox proportional hazard regression was used to investigate the risk of CVD associated with NSAID use. Results Of the 19 775 patients (mean age, 36 years; 75% were male), 19 706 received NSAID treatment. During follow-up period of 98 290 person-years, 1663 cases of CVD occurred including 1157 cases of ischaemic heart disease, 301 cases of stroke and 613 cases of congestive heart failure. Increasing dose of NSAIDs was associated with incident CVD after adjusting for confounders (adjusted HR (aHR) 1.10; 95% CI 1.08 to 1.13). Specifically, increasing dose of NSAIDs was associated with incident ischaemic heart disease (aHR 1.08; 95% CI 1.05 to 1.11), stroke (aHR 1.09; 95% CI 1.04 to 1.15) and congestive heart failure (aHR 1.12; 95% CI 1.08 to 1.16). The association between NSAID dose and higher CVD risk was consistent in different subgroups. Conclusion In a real-world AS cohort, higher dose of NSAID treatment was associated with a higher risk of CVD, including ischaemic heart disease, stroke and congestive heart failure.
Combined inhibition of IL-1, IL-33 and IL-36 signalling by targeting IL1RAP ameliorates skin and lung fibrosis in preclinical models of systemic sclerosis
Authors: Caitríona Grönberg, Sara Rattik, Cuong Tran-Manh, Xiang Zhou, Aleix Rius Rigau, Yi-Nan Li, Andrea-Hermina Györfi, Nicholas Dickel, Meik Kunz, Alexander Kreuter, Emil-Alexandru Matei, Honglin Zhu, Petter Skoog, David Liberg, Jörg HW Distler, Thuong Trinh-Minh
Journal: Annals of the Rheumatic Diseases (2024)

The interleukin (IL)-1 receptor accessory protein (IL1RAP) is an essential coreceptor required for signalling through the IL-1, IL-33 and IL-36 receptors. Here, we investigate the antifibrotic potential of the combined inhibition of these cytokines by an anti-IL1RAP antibody to provide a scientific background for clinical development in systemic sclerosis (SSc).