tbuckley/cabot-search huggingface dataset:
Hepatic fascioliasis: a rare case of “fake” biliary gallstones
Authors: Michele Amata, Giovanni Boncori, Daniela Scimeca, Filippo Mocciaro, Ambra Bonaccorso, Claudia Colomba, Roberto Di Mitri
Journal: Endoscopy (2024)

A 52-year-old woman who had previously traveled to a developing country was admitted to our emergency department with fever, colicky abdominal pain, and pruritus. Laboratory tests showed hypereosinophilia (1432 eosinophils/µL, limit value <500) and direct hyperbilirubinemia (2.5 mg/dL, reference range 0–1.3 mg/dL). Magnetic resonance cholangiopancreatography revealed endoluminal filling defects into a dilated common bile duct (CBD) and in the gallbladder ([Fig. 1]). Endoscopic retrograde cholangiopancreatography (ERCP) was then planned to treat choledocholithiasis.
An unusual pancreas divisum intraductal papillary mucinous neoplasm diagnosed by pancreatoscopy-assisted endoscopic ultrasonography rendezvous procedure
Authors: Belén Agudo Castillo, Daniel de la Iglesia, Carlos Esteban Fernández-Zarza, Esther Maderuelo González, Ana Isabel Cabrero Cabrero, Paula Aguirre-Camino, Mariano González-Haba Ruiz
Journal: Endoscopy (2024)

This video case report presents the endoscopic management of a main duct intraductal papillary mucinous neoplasm (IPMN) in a 75-year-old patient with a history of acute pancreatitis.
Mucosal snare resection-endoscopic submucosal excavation: a novel technology
Authors: Yongli Ye, Yiping Hong, Wei Wei, Xiaowei Ji, Xinliang Lu
Journal: Endoscopy (2024)

Endoscopic submucosal excavation (ESE) is a less invasive therapeutic alternative to surgical resection for the removal of gastric submucosal tumors [1]. The conventional procedural steps of this technique all involve cautery markings to delineate the target lesion, followed by submucosal injection and the resection of the lesion using a hook knife, insulation-tipped knife, or dual knife, and finally, closure of the mucosal incision using clips [2]. We report a novel variant ESE technique, mucosal snare resection-endoscopic submucosal excavation (MSR-ESE), for a lower technical burden and shorter procedure time compared with ESE.
Use of adaptive traction for endoscopic submucosal dissection when using a bipolar knife for cardiological reasons
Authors: Elena De Cristofaro, Louis Jean Masgnaux, Jérôme Rivory, Jérémie Jacques, Jean Grimaldi, Mathieu Pioche
Journal: Endoscopy (2024)

Endoscopic submucosal dissection (ESD) allows en bloc resection of gastrointestinal lesions, providing completeness of resection and facilitating accurate histological assessment. The knives currently in use for ESD are monopolar devices that can cause electromagnetic interference with cardiac implantable electronic devices (CIEDs). Speedboat (Speedboat-RS2; Creo Medical Ltd, Chepstow, UK) is a novel bipolar device designed for ESD, which utilizes advanced energy (radiofrequency and microwave) for dissection and coagulation. It is an all-in-one device, capable of executing submucosal injection, dissection, and coagulation, making the procedure faster without interfering with CIEDs [1]. We report the use of this device during ESD with an adaptive traction instrument (A-TRACT 2+2; Hospices civils de Lyon, Lyon, France), the benefits of which have been described previously ([Video 1]) [2] [3] [4] [5].
A new endoscopic solution for rectal anastomotic atresia: Contrast agent-guided precision dilation
Authors: Huawei Yang, Shaotong Wang, Rui Ji
Journal: Endoscopy (2024)

A 73-year-old man was admitted to our hospital due to rectal anastomosis atresia following prior treatments involving total colectomy, ileostomy establishment, and ileorectal end-to-side anastomosis for intestinal obstruction and ischemic necrosis approximately 4 months previously. Colonoscopy revealed occluded anastomosis 18 cm distal from the anus, characterized by the presence of white scarring and a prominent aggregation of mucosal folds at its central juncture ([Fig. 1]). To precisely locate the proximal intestinal lumen, an injection needle (VedNeedle, 22G diameter; Vedkang Medical, Jiangsu, China) was used to penetrate the occlusion. After injecting the contrast medium, X-ray fluoroscopy revealed the appropriate localization of the contrast medium within the distal intestinal lumen ([Fig. 2]). Guided by a guidewire (Jagwire, 0.035-diameter; Boston Scientific, Marlborough, Massachusetts, USA) through the incision knife, the anastomosis was then opened by a small incision in the occlusion, resulting in a controlled incision ([Fig. 3]). An 8.0-mm biliary dilation balloon further opened the anastomosis successfully ([Fig. 4]). After 2 weeks, a follow-up colonoscopy revealed anastomotic stenosis, which hindered the passage of an Olympus GIF Q260J scope (Olympus, Tokyo, Japan). To address this, a dilation balloon with a guidewire was introduced through the stenosis, and a 12-mm balloon was inflated, effectively expanding the anastomosis ([Fig. 5]). The endoscope passed easily through the anastomosis ([Video 1]). One month later, the patient made a positive recovery, leading to the successful ileostomy reversal procedure.
Unraveling the conumdrum: innovative technique to remove the stent from the displaced pancreatic duct in stenosis
Authors: Junqian Chen, Shuting Wen, Xiaofeng Lin, Zhuodan Zhong, Yan Guo, Dongjing Zhou, Tianwen Liu
Journal: Endoscopy (2024)

Stent migration from the pancreatic duct (PD) is a relatively rare but serious complication [1]. If not treated in a timely way, it can lead to serious illnesses, such as recurrent pancreatitis, jaundice, pancreatic cysts, infection, etc. [2]. It is challenging to remove the displaced PD stent, especially in the presence of a PD stenosis, stent distortion, and adhesion to surrounding tissues [3].
Successful closure of a detached muscle layer during gastric endoscopic submucosal dissection with fibrosis using clips with the use of polyglycolic acid sheets and fibrin glue
Authors: Satoshi Abiko, Koji Hirata, Kazuharu Suzuki, Kenji Kinoshita, Kazuteru Hatanaka, Yoshiya Yamamoto, Hirohito Naruse
Journal: Endoscopy (2024)

Resections of gastric tumors with severe fibrosis by the endoscopic submucosal dissection (ESD) procedure are still difficult in some cases [1]. Perforation is a major complication of ESD with severe fibrosis [2]; however, there has been no report of adverse events such as a huge, detached muscle layer. Here we report successful closure of a huge, detached muscle layer during gastric ESD with severe fibrosis using clips with the use of polyglycolic acid (PGA) sheets and fibrin glue.
Gallstone sigmoid obstruction treated with electrohydraulic lithotripsy
Authors: Jesus A. Guzman, Bhavi Trivedi, Mohammad Bashashati, Vital Rangashamanna, Brian Davis, Ihsan Al-Bayati, Sherif E. Elhanafi
Journal: Endoscopy (2024)

Gallstone is a rare cause of large-bowel obstruction. It can result in complete mechanical obstruction in the setting of underlying distal benign or malignant narrowing [1]. Traditionally, surgery is considered the primary treatment modality but carries elevated morbidity and mortality, making nonoperative approaches such as endoscopic mechanical or electrohydraulic lithotripsy (EHL) an integral part of the management [2].
Needle-free technique for guidewire manipulation during endoscopic ultrasound-guided pancreatic duct drainage
Authors: Takeshi Ogura, Masahiro Yamamura, Mitsuki Tomita, Jun Sakamoto, Hiroki Nishikawa
Journal: Endoscopy (2024)

Endoscopic ultrasound-guided pancreatic duct drainage (EUS-PD) is considered if the pancreatic duct approach under endoscopic retrograde cholangiopancreatography guidance is unsuccessful due to failure of pancreatic duct cannulation or an inaccessible papilla [1] [2] [3]. During EUS-PD, guidewire manipulation may be one of the limiting steps, especially in nonexpert hands [4]. Guidewire manipulation may fail due to the guidewire shearing against the needle. During EUS-guided hepaticogastrostomy, to prevent guidewire shearing, the liver impaction technique can be attempted [5]; however, during EUS-PD, the short length of pancreatic parenchyma on the puncture route may render this technique challenging. To overcome this, technical tips for a needle-free technique during EUS-PD are described.
Endoscopic hand-suturing for postoperative suture failure
Authors: Naosuke Kuraoka, Tetsuro Ujihara, Shun Sakai, Haruhiko Okada, Satoru Hashimoto
Journal: Endoscopy (2024)

An 82-year-old man underwent robot-assisted total gastrectomy for gastric cancer. On postoperative day 5, a pancreatic leak was observed and open abdominal drainage was performed. Upper gastrointestinal (UGI) endoscopy performed on postoperative day 29 revealed delayed suture failure at the esophagojejunal anastomosis and dissection of the anastomosis ([Fig. 1]). The patient's general condition was poor, and it was difficult to re-suture the anastomosis. The pancreatic leak was managed with drainage, allowing the patient's nutritional status to improve.
Use of natriuretic peptides and echocardiography for diagnosing heart failure
Authors: Khawaja M. Talha, James L. Januzzi, Tong Meng, Stephen J. Greene, Muthiah Vaduganathan, Tijana K. Janicijevic, Ani John, Antoni Bayes‐Genis, Javed Butler
Journal: European Journal of Heart Failure (2024)
Federal Housing Assistance and Blood Lead Levels in a Nationally Representative US Sample Age 6 and Older: NHANES, 1999–2018
Authors: MyDzung T. Chu, Andrew Fenelon, Gary Adamkiewicz, Ami R. Zota
Journal: Environmental Health Perspectives (2024)

Federal housing assistance is an important policy tool to ensure housing security for low-income households. Less is known about its impact on residential environmental exposures, particularly lead.
Endocrine and Targeted Therapy for Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer—Capivasertib-Fulvestrant: ASCO Rapid Recommendation Update
Authors: Harold J. Burstein, Angela DeMichele, Lesley Fallowfield, Mark R. Somerfield, N. Lynn Henry, N. Lynn Henry, Zoneddy Dayao, Anthony Elias, Kevin Kalinsky, Lisa M. McShane, Beverly Moy, Ben Ho Park, Kelly M. Shanahan, Priyanka Sharma, Rebecca Shatsky, Erica Stringer-Reasor, Melinda Telli, Nicholas C. Turner, Angela DeMichele, Harold J. Burstein, Debra L. Barton, Ali Dorris, Lesley J. Fallowfield, Dharamvir Jain, Stephen R.D. Johnston, Larissa A. Korde, Jennifer K. Litton, Erin R. Macrae, Lindsay L. Peterson, Praveen Vikas, Rachel L. Yung, Hope S. Rugo
Journal: Journal of Clinical Oncology (2024)

ASCO Rapid Recommendation Updates highlight revisions to select ASCO guideline recommendations as a response to the emergence of new and practice-changing data. The rapid updates are supported by an evidence review and follow the guideline development processes outlined in the ASCO Guideline Methodology Manual. The goal of these articles is to disseminate updated recommendations, in a timely manner, to better inform health practitioners and the public on the best available cancer care options. Guidelines and updates are not intended to substitute for independent professional judgment of the treating provider and do not account for individual variation among patients. See appendix for disclaimers and other important information ( Appendix 1 and Appendix 2 , online only).
KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease
Authors: Paul E. Stevens, Sofia B. Ahmed, Juan Jesus Carrero, Bethany Foster, Anna Francis, Rasheeda K. Hall, Will G. Herrington, Guy Hill, Lesley A. Inker, Rümeyza Kazancıoğlu, Edmund Lamb, Peter Lin, Magdalena Madero, Natasha McIntyre, Kelly Morrow, Glenda Roberts, Dharshana Sabanayagam, Elke Schaeffner, Michael Shlipak, Rukshana Shroff, Navdeep Tangri, Teerawat Thanachayanont, Ifeoma Ulasi, Germaine Wong, Chih-Wei Yang, Luxia Zhang, Adeera Levin
Journal: Kidney International (2024)

This article is published as part of a supplement sponsored by Kidney Disease: Improving Global Outcomes (KDIGO). The opinions or views expressed in this supplement are those of the authors and do not necessarily reflect the opinions or recommendations of the International Society of Nephrology or Elsevier. Dosages, indications, and methods of use for products that are referred to in the supplement by the authors may reflect their clinical experience or may be derived from the professional literature or other clinical sources.
Thread-structural microneedles loaded with engineered exosomes for annulus fibrosus repair by regulating mitophagy recovery and extracellular matrix homeostasis
Authors: Shaojun Hu, Meng Zhu, Hongyuan Xing, Yucheng Xue, Jun Li, Zhan Wang, Zhou Zhu, Miaojie Fang, Zilong Li, Jianbin Xu, Yong He, Ning Zhang
Journal: Bioactive Materials (2024)

Low back pain is among the most grave public health concerns worldwide and the major clinical manifestation of intervertebral disc degeneration (IVDD). The destruction of annulus fibrosus (AF) is the primary cause of IVDD. A sustainable and stable treatment system for IVDD is lacking because of the special organizational structure and low nutrient supply of AF. We here found that IVDD results in the impaired mitochondrial function of AF tissue, and mitochondrial autophagy (mitophagy) plays a protective role in this process. We therefore reported a thread-structural microneedle (T-MN) matching the ring structure of AF. Based on the adsorption effect of laminin, our T-MN could load with bone marrow mesenchymal stem cell-derived exosomes to envelope the regulating mitophagy microRNA (miRNA 378), named as T-MN
Engineered nanomicelles inhibit the tumour progression via abrogating the prostaglandin-mediated immunosuppression
Authors: Poonam Yadav, Kajal Rana, Viviani Nardini, Ali Khan, Trishna Pani, Animesh Kar, Dolly Jain, Ruchira Chakraborty, Ragini Singh, Somesh K Jha, Devashish Mehta, Harsh Sharma, Ravi Datta Sharma, S V S Deo, Sagar Sengupta, Veena S Patil, Lúcia Helena Faccioli, Ujjaini Dasgupta, Avinash Bajaj
Journal: Journal of Controlled Release (2024)
Intraventricular CARv3-TEAM-E T Cells in Recurrent Glioblastoma
Authors: Bryan D Choi, Elizabeth R Gerstner, Matthew J Frigault, Mark B Leick, Christopher W Mount, Leonora Balaj, Sarah Nikiforow, Bob S Carter, William T Curry, Kathleen Gallagher, Marcela V Maus
Journal: New England Journal of Medicine (2024)

SummaryIn this first-in-human, investigator-initiated, open-label study, three participants with recurrent glioblastoma were treated with CARv3-TEAM-E T cells, which are chimeric antigen receptor (CAR) T cells engineered to target the epidermal growth factor receptor (EGFR) variant III tumor-specific antigen, as well as the wild-type EGFR protein, through secretion of a T-cell–engaging antibody molecule (TEAM). Treatment with CARv3-TEAM-E T cells did not result in adverse events greater than grade 3 or dose-limiting toxic effects. Radiographic tumor regression was dramatic and rapid, occurring within days after receipt of a single intraventricular infusion, but the responses were transient in two of the three participants. (Funded by Gateway for Cancer Research and others; INCIPIENT ClinicalTrials.gov number, NCT05660369.)
Effects of Behavioral, Clinical, and Policy Interventions in Reducing Human Exposure to Bisphenols and Phthalates: A Scoping Review
Authors: Nicole E. Sieck, Meg Bruening, Irene van Woerden, Corrie Whisner, Devon C. Payne-Sturges
Journal: Environmental Health Perspectives (2024)

There is growing interest in evidence-based interventions, programs, and policies to mitigate exposures to bisphenols and phthalates and in using implementation science frameworks to evaluate hypotheses regarding the importance of specific approaches to individual or household behavior change or institutions adopting interventions.
Genetically Predicted Body Mass Index and Mortality in COPD
Authors: Jingzhou Zhang, Matthew Moll, Brian D. Hobbs, Per Bakke, Elizabeth A Regan, Hanfei Xu, Josée Dupuis, Joe W Chiles, Merry-Lynn N. McDonald, Miguel J. Divo, Edwin K Silverman, Bartolome R. Celli, George T O'Connor, Michael H Cho
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

Body mass index (BMI) is associated with chronic obstructive pulmonary disease (COPD) mortality, but the underlying mechanisms are unclear. The effect of genetic variants aggregated into a polygenic score may elucidate the causal mechanisms and predict risk.
Association of healthy lifestyle behaviours with incident irritable bowel syndrome: a large population-based prospective cohort study
Authors: Fai Fai Ho, Hui Sun, Hong Zheng, David C N Wong, Yin-Yan Gao, Chen Mao, Yin Ting Cheung, Chun Sing Lam, Maggie H Wang, Irene Xin-Yin Wu, Justin C Y Wu, Vincent C H Chung
Journal: Gut (2024)

Objectives To evaluate the association between healthy lifestyle behaviours and the incidence of irritable bowel syndrome (IBS). Design Population-based prospective cohort study. Setting The UK Biobank. Participants 64 268 adults aged 37 to 73 years who had no IBS diagnosis at baseline were enrolled between 2006 and 2010 and followed up to 2022. Main exposure The five healthy lifestyle behaviours studied were never smoking, optimal sleep, high level of vigorous physical activity, high dietary quality and moderate alcohol intake. Main outcome measure The incidence of IBS. Results During a mean follow-up of 12.6 years, 961 (1.5%) incident IBS cases were recorded. Among the 64 268 participants (mean age 55.9 years, 35 342 (55.0%) female, 7604 (11.8%) reported none of the five healthy lifestyle behaviours, 20 662 (32.1%) reported 1 behaviour, 21 901 (34.1%) reported 2 behaviours and 14 101 (21.9%) reported 3 to 5 behaviours at baseline. The multivariable adjusted hazard ratios associated with having 1, 2 and 3 to 5 behaviours for IBS incidence were 0.79 (95% confidence intervals 0.65 to 0.96), 0.64 (0.53 to 0.78) and 0.58 (0.46 to 0.72), respectively (P for trend &lt;0.001). Never smoking (0.86, 0.76 to 0.98, P=0.02), high level of vigorous physical activity (0.83, 0.73 to 0.95, P=0.006) and optimal sleep (0.73, 0.60 to 0.88, P=0.001) demonstrated significant independent inverse associations with IBS incidence. No significant interactions were observed between these associations and age, sex, employment status, geographic location, gastrointestinal infection, endometriosis, family history of IBS or lifestyle behaviours. Conclusions Adhering to a higher number of healthy lifestyle behaviours is significantly associated with a lower incidence of IBS in the general population. Our findings suggest the potential of lifestyle modifications as a primary prevention strategy for IBS.
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk
Authors: Xiangyu Zhang, Divya Kapoor, Se-Jin Jeong, Alan Fappi, Jeremiah Stitham, Vasavi Shabrish, Ismail Sergin, Eman Yousif, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Arick Park, Arif Yurdagul, Oren Rom, Slava Epelman, Joel D Schilling, Marco Sardiello, Abhinav Diwan, Jaehyung Cho, Nathan O Stitziel, Ali Javaheri, Irfan J Lodhi, Bettina Mittendorfer, Babak Razani
Journal: Nature Metabolism (2024)
A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism
Authors: Khaled Tighanimine, José Américo Nabuco Leva Ferreira Freitas, Ivan Nemazanyy, Alexia Bankolé, Delphine Benarroch-Popivker, Susanne Brodesser, Gregory Doré, Lucas Robinson, Paule Benit, Sophia Ladraa, Yara Bou Saada, Bertrand Friguet, Philippe Bertolino, David Bernard, Guillaume Canaud, Pierre Rustin, Eric Gilson, Oliver Bischof, Stefano Fumagalli, Mario Pende
Journal: Nature Metabolism (2024)

Abstract Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes of senescence, we show that a homoeostatic switch that results in glycerol-3-phosphate (G3P) and phosphoethanolamine (pEtN) accumulation links lipid metabolism to the senescence gene expression programme. Mechanistically, p53-dependent glycerol kinase activation and post-translational inactivation of phosphate cytidylyltransferase 2, ethanolamine regulate this metabolic switch, which promotes triglyceride accumulation in lipid droplets and induces the senescence gene expression programme. Conversely, G3P phosphatase and ethanolamine-phosphate phospho-lyase-based scavenging of G3P and pEtN acts in a senomorphic way by reducing G3P and pEtN accumulation. Collectively, our study ties G3P and pEtN accumulation to controlling lipid droplet biogenesis and phospholipid flux in senescent cells, providing a potential therapeutic avenue for targeting senescence and related pathophysiology.
Skin‐Mountable Functional Electronic Materials for Bio‐Integrated Devices
Authors: Jin Young Oh, Yeongjun Lee, Tae‐Woo Lee
Journal: Advanced Healthcare Materials (2024)

Skin-mountable electronic materials are being intensively evaluated for use in bio-integrated devices that can mutually interact with the human body. Over the past decade, functional electronic materials inspired by the skin are developed with new functionalities to address the limitations of traditional electronic materials for bio-integrated devices. Herein, the recent progress in skin-mountable functional electronic materials for skin-like electronics is introduced with a focus on five perspectives that entail essential functionalities: stretchability, self-healing ability, biocompatibility, breathability, and biodegradability. All functionalities are advanced with each strategy through rational material designs. The skin-mountable functional materials enable the fabrication of bio-integrated electronic devices, which can lead to new paradigms of electronics combining with the human body.
Prevalence of endoscopy-related injuries and their impact on clinical practice: a systematic review and meta-analysis
Authors: Achintya D Singh, Nishant Aggarwal, Babu P Mohan, Deepak Madhu, Gengqing Song, Amit Bhatt, Prabhleen Chahal, Marc Landsman
Journal: Endoscopy (2024)

Endoscopy-related musculoskeletal injuries (ERIs) are commonly reported but their exact prevalence and clinical impact remain obscure. We conducted a systematic review and meta-analysis of the current literature aiming to answer these questions.
Pan-intestinal capsule endoscopy as first-line procedure in patients with suspected mid or lower gastrointestinal bleeding
Authors: Bruno Rosa, Tiago Cúrdia Gonçalves, Maria J. Moreira, Francisca Dias de Castro, Bernardo Sousa-Pinto, Mário Dinis-Ribeiro, José Cotter
Journal: Endoscopy (2024)

Pan-intestinal capsule endoscopy (PCE) evaluates the small bowel and colon noninvasively. This study evaluated diagnostic accuracy and safety of PCE vs. colonoscopy as first-line examination in suspected mid-lower gastrointestinal bleeding (MLGIB).
Contrast-enhanced endoscopic ultrasound-guided fine-needle aspiration for a gastric submucosal tumor with surrounding hemorrhage
Authors: Yuki Utakata, Takuji Iwashita, Shota Iwata, Akihiko Senju, Ryuichi Tezuka, Shinya Uemura, Masahito Shimizu
Journal: Endoscopy (2024)

Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) represents a useful and less invasive procedure for procuring pathological specimens from lesions located either in proximity to or within the gastrointestinal wall [1] [2]. Contrast-enhanced EUS (CE-EUS) is known to be advantageous for differential diagnosis in various types of tumors, as it provides real-time blood flow images [3]. In this report, we present a patient with a gastric submucosal tumor associated with hemorrhage, in whom CE-EUS-guided FNA (CE-EUS-FNA) had a pivotal role in precisely identifying the lesion and facilitating accurate FNA.