EXPERIMENTAL THROMBOPENIC PURPURA; CYTOLOGICAL AND PHYSICAL CHANGES IN THE BLOOD
Authors: Leandro M. Tocantins
Journal: Annals of Internal Medicine (1936)

Article1 January 1936EXPERIMENTAL THROMBOPENIC PURPURA; CYTOLOGICAL AND PHYSICAL CHANGES IN THE BLOODLEANDRO M. TOCANTINSLEANDRO M. TOCANTINSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-7-838 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen a moderate dose of antiplatelet serum is given to a dog, the animal develops an attack of purpura hemorrhagica, identical in most respects with the human type, and recovers spontaneously. The changes that accompany such a disease in the dog have not as yet been systematically investigated. The observations here presented are the result of a study of some of these changes in a group of 63 dogs in each one of which purpura was produced one or more times.EXPERIMENTAL METHODSCytology. Various methods of counting platelets1, 2, 3were tried and the direct method was finally selected....References1. WRIGHTKINNICUTT JHR: A new method of counting the blood platelets for clinical purposes, Jr. Am. Med. Assoc., 1911, lvi, 1457-1459. CrossrefGoogle Scholar2. GRAM HC: Blood platelets in influenza, with remarks on the technic of counting, Acta med. Scandinav., 1920, liv, 1-6. Google Scholar3. FONIO A: Die Bestimmung der Prognose der Blutstillung; Zentrifugiermethode, Archiv. f. klin. Chirur., 1928, clii, 459-476. Google Scholar4. TOCANTINS LM: Platelets and the spontaneous syneresis of blood clots, Am. Jr. Physiol., 1934, cx, 278-286. CrossrefGoogle Scholar5. DUNN HL: Application of statistical methods in physiology, Physiol. Rev., 1929, ix, 275-398. CrossrefGoogle Scholar6. PEARL R: Introduction to medical biometry and statistics, 1923, W. B. Saunders and Co., Philadelphia. Google Scholar7. DAY EE: Statistical analysis, 1925, Macmillan and Co., New York. Google Scholar8. BLAKEMAN J: On tests for linearity and regression in frequency distributions, Biometrika, 1905, iv, 332-350. CrossrefGoogle Scholar9. TOCANTINS LM: Experimental thrombopenic purpura in dogs, Arch. Pathol. (In press.) Google Scholar10. AYNAUD M: Le globulin des mammifères, Thèse de Paris, 1909. Google Scholar11. ROSKAM J: Purpuras hémorrhagiques et thrombopénie, Sang, 1934, viii, 129-169. Google Scholar12. SACERDOTTI C: Le piastrine dei mammiferi e il siero antipiastrinico, Arch. per le sc. med., 1908, xxxii, 338-404. Google Scholar13. STEELE BF: Effects of blood loss and blood destruction upon the erythroid cells in bone marrow of rabbits, Jr. Exper. Med., 1933, lvii, 881-896. CrossrefGoogle Scholar14. RUSSELL PF: Avian malaria studies. VIII. Bleeding time in canaries; normal and in malaria, Philippine Jr. Sci., 1932, xlix, 627-647. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Read at the Philadelphia meeting of the American College of Physicians, April 30, 1935.†J. Ewing Mears Research Fellow, Department of Medicine, Jefferson Medical College, Philadelphia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPlateletsTurnover in Cells and TissuesLITERATURVERZEICHNISTHE ROLE OF LEUKOCYTE AND PLATELET ANTIBODY TESTS IN MANAGEMENT OF DIVERSE CLINICAL DISORDERS*†JAMES L. TULLIS, M.D., F.A.C.P.ALLERGISCHE BEZIEHUNGEN VON KRANKHEITEN DER BLUTBILDENDEN ORGANEPlatelet Antibody Tests in the Diagnosis of PurpuraIMMUNOLOGIC MECHANISMS IN IDIOPATHIC AND NEONATAL THROMBOCYTOPENIC PURPURA*WILLIAM J. HARRINGTON, M.D., CHARLES C. SPRAGUE, M.D., VIRGINIA MINNICH, M.S., CARL V. MOORE, M.D., F.A.C.P., ROBERT C. AULVIN, B.S., REUBENIA DUBACH, Ph.D.THE PLATELETS OF HUMAN BLOOD: THEIR MORPHOLOGY, INTERACTIONS, AND PRESERVATIONHemorrhagic Diseases 1 January 1936Volume 9, Issue 7Page: 838-849KeywordsBloodCell biologyHemorrhage ePublished: 1 December 2008 Issue Published: 1 January 1936 PDF downloadLoading ...