tbuckley/cabot-search huggingface dataset:
Transfusion History, Iron Chelation Practices and Status of Iron Overload across Various Transfusion-Dependent Anemias: Data from the Large- Scale, Prospective, 1-Year EPIC Trial
Authors: Maria Domenica Cappellini, Norbert Gattermann, Vip Viprakasit, Jong Wook Lee, John B Porter, Amal El-Beshlawy, Antonis Kattamis, John F Seymour, Chi-Kong Li, Dany Habr, Gabor Domokos, Abdel Hmissi, Mohsen Saleh Elalfy
Journal: Blood (2008)
Long-Term Safety and Efficacy of Gene Therapyfor Adenosine Deaminase (ADA)-Deficient Severe Combined Immunodeficiency
Authors: A Aiuti, F Cattaneo, S Galimberti, U Benninghoff, B Cassani, L Callegaro, S Scaramuzza, G Andolfi, M Mirolo, I Brigida, A Tabucchi, F Carlucci, M Eibl, M Aker, S Slavin, H Al-Mousa, A Al Ghonaium, A Duppenthaler, N Luigi, U Wintergerst, Hb R, M Bregni, S Marktel, M Valsecchi, P Rossi, F Ciceri, R Miniero, C Bordignon, M Roncarolo
Journal: New England Journal of Medicine (2009)
Emotional problems of residents in psychiatry
Authors: A T Russell, R O Pasnau, Z C Taintor
Journal: American Journal of Psychiatry (1975)

The authors used a questionnaire technique to determine the magnitude of the problem of emotional illness and poor performance during psychiatric residency, the procedures that are used to screen for or help disturbed residents, and characteristics that differentiate residents who are at risk. The data indicated that residents who have problems that lead to termination are rarely free of emotional disturbance. The general belief that women, foreign medical graduates, and minority group members are at higher risk for problems during residency was not supported; however, younger residents and transfers from other programs appeared to be at risk. A disturbing finding was the high rate of suicide reported. The authors stress the need for further work with the "marginal" resident and for research on screening and supportive procedures.
Untersuchungen über den Syphiliserreger.
Authors: F. Walther Oelze
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Klinik und Therapie akuter Vergiftungen.
Authors: Ludwig Popper
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
L'état actuel de l'étude des réflexes.
Authors: M. Minkowski
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 20276: Tetralogy of Fallot With Hypoplastic Branch Pulmonary Arteries: Aggressive Patch Augmentation Improves Short-Term Geometry but Increases Risk of Late Re-Interventions
Authors: Travis J Wilder, Glenn Van Arsdell, Eric Pham-Hung, Michael Gritti, Saro Hussain, Christopher A Caldarone, Andrew Redington, Edward J Hickey
Journal: Circulation (2014)

Introduction:  When encountering hypoplastic branch pulmonary arteries (PA) during tetralogy of Fallot repair (TOF), strategies include: 1) patch augment to hilum (PATCH), 2) extending patches into proximal part only (EXTEND), or 3) leave native vessels uninstrumented in anticipation of growth (NATIVE). We tested outcomes for these opposing strategies.   Methods:  We studied all 434 TOF repairs (2000-12, excluding pulmonary atresia). Risk-adjusted models analyzed competing endstates of branch PA reintervention or death. PA growth was explored via repeated measures analysis of 2123 echo measurements. Subgroup analysis of children with branch PA    Results:  Overall survival was excellent (99%; 3 deaths). Mean freedom from catheter or surgical re-intervention to branch PAs at 10 years was 84%. In models risk-adjusted for baseline features (including PA size), PATCH augmentation of branch PAs was associated with significantly higher rates of re-intervention (75% freedom; p  Branch PA   In PATCH(28), EXTEND(60) and REPAIR(75) groups, freedom from re-intervention adjusted for BPA z-score was 60%, 70% and 80% respectively, and patient characteristics were similar (figure). More PATCH children had received PA stents (P=.04), but the majority of all groups had not (figure). Aggressive PATCH strategy was associated with decreased time-related branch PA growth (p=.02, 667 echos).   Conclusions:  Aggressive patch augmentation of branch PAs improves short-term geometry but may lead to late stenosis and higher rates of re-intervention. Hypoplastic branch PAs in TOF tend to grow well in their native state or with minimal surgical manipulation.
Somatization: Physical Symptoms and Psychological Illness
Authors: Christopher M. Bass, R. H. Cawley
Journal: Annals of Internal Medicine (1991)

Classification of the somatoform disorders Assessment and management of patients with functional somatic symptoms Somatization in primary care settings Fatigue and chronic fatigue syndromes Functional abdominal pain Functional cardiorespiratory syndromes Disorders of hysterical conversion Gynaecological complaints Chronic pelvic pain in women Dermatological complaints Somatization disorder: critique of the concept and suggestions for future research
Markers of Colonic Cell Differentiation&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Authors: Sandra R. Wolman, Anthony J. Mastromarino
Journal: JNCI Journal of the National Cancer Institute (1984)

Markers of Colonic Cell Differentiation Get access Sandra R. Wolman, M.D., Sandra R. Wolman, M.D. 1Department of Pathology, School of Medicine New York University Medical CenterNew York, New York 10016 Search for other works by this author on: Oxford Academic PubMed Google Scholar Anthony J. Mastromarino, Ph.D. Anthony J. Mastromarino, Ph.D. 2National Large Bowel Cancer Project M. D. Anderson Hospital and Tumor Institute The University of Texas System Cancer Center6723 Bertner Avenue, Box 210 Houston, Texas 77030 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 72, Issue 2, February 1984, Pages 497–500, https://doi.org/10.1093/jnci/72.2.497 Published: 01 February 1984
Urinary Calculi: ESWL, Endourology, and Medical Therapy
Authors: Daniel M. Newman, Lynwood H. Smith, John R. Woods
Journal: Annals of Internal Medicine (1990)

The presentation of the material could have been better organized. The text begins with an appropriate review ofthe pelvic anatomy (one of the outstanding chapters in the book), followed by a chapter on reduction of maternal injuries associated with childbirth. The next few chapters discuss appropriate selection of operative procedures. The eighth chapter reviews instruments and sutures, and the ninth is devoted to minor ambulatory operations. These last two chapters should be located either at the beginning or at the end of the text, rather than in the middle of the material on basic vaginal procedures. Similarly, the chapters on urinary incontinence belong in the same section as those on diverticulum and fistula formation of the urinary tract, and the chapters devoted to lacerations of the perineum should be grouped with those that address rectovaginal fistula and retrorectal levatorplasty. The chapter that reviews operations for stress incontinence is incomplete, and only 4 of the 44 references were published during the past 10 years. In contrast, the chapter on vaginal hysterectomy is outstanding, including excellent illustrations and numerous points that reflect the vast experience of the authors. Alternative means of morcellating a large uterus are well illustrated, and a thorough discussion of appropriate reconstruction of the pelvis is presented. Dr. Nichols is known worldwide for his revival of the technique of sacrospinous ligament fixation for massive inversion of the vagina. The color illustrations of this procedure clearly demonstrate the placement of this suture within the ligament. The authors emphasize practical points that will help ensure excellent results and minimize potential complications. The chapters devoted to urethral diverticuIurn and vesicovaginal and rectovaginal fistulas are well illustrated and informative. The section on creation of a neovagina is thorough, but the McIndoe procedure is inadequately illustrated and incompletely reviewed. The bibliographies in these chapters are incomplete. In general, this is a well-written, easy to read text. Because it covers areas that are often poorly understood by clinicians, I recommend it Mayo Cltn Proc, June 1990, Vol 65
Abstract 223: Impact of the Number of On-Scene Emergency Lifesaving Technicians and Outcomes from Out-of-Hospital Cardiac Arrests
Authors: Kentaro Kajino, Taku Iwami, Mohamud Daya, Tetsuhisa Kitamura, Tatsuya Nishiuchi, Yasuyuki Hayashi, Tomohiko Sakai, Takeshi Shimazu, Atsushi Hiraide, Masashi Kishi, Shigeru Yamayoshi
Journal: Circulation (2011)

Introduction: In Japan, ambulance staffing for cardiac arrest responses consists of a 3-person unit with at least one emergency life saving technician (ELST). ELST's are trained in advanced airway techniques and can administer epinephrine with medial control approval. Recently, the number of ELST's on ambulances has increased since it is believed that this staffing model improves the quality of on-scene care leading to improved patient outcome. Purpose: The aim of this study was to evaluate the relationship between the number of ELSTs on scene and outcomes from OHCA. Materials and methods: This was a prospective cohort study including all persons aged &gt;=18 years suffering OHCA witnessed by bystanders in Osaka City, Japan from January 2005 through December 2007. All data were collected using an Utstein-style database. Odds ratio of the number of ELSTs on scene for neurologically favorable one-month survival (CPC ≤ 2) were calculated using multiple logistic regression adjusting for the following confounding variables; gender, age, bystander CPR, location, epinephrine, advanced airway, EMS scene time, etiology, and first rhythm. Results: Of the 2430 witnessed OHCA patients, one ELST group was present in 644, two ELST group were present in 1370, and three ELST group in 416.The proportion of neurologically favorable one month survival was 4.3% in the one ELST, 5.1% in the two ELST, and 7.7% in the three ELST group. Compared with the one ELST group, the three ELST group had a significantly greater odds ratio for CPC ≤ 2 after adjustment for confounding variables. Conclusion: Increasing number of ELSTs on scene was associated with improved outcomes from OHCA in Osaka.
Randomized, multicenter, phase III trial of docetaxel plus epirubicin (ET) with or without capecitabine (X) as first-line therapy for stage IV breast cancer (BC)
Authors: M. Mansutti, G. Cavazzini, V. Lorusso, C. Boni, M. Occelli, F. Puglisi, L. Del Mastro, M. Venturini
Journal: Journal of Clinical Oncology (2008)

1034 Background: Anthracycline-taxane combinations are among the most active chemotherapy regimens for BC. We conducted a phase III trial to explore whether adding X to ET could further improve outcomes. Methods: Patients (pts) with stage IIIb or IV BC were randomized to 3-weekly cycles of either ET (E 75 mg/m2 + T 75 mg/m2, both d1) or TEX (ET as above + X 1000 mg/m2 bid, d1–14). Primary endpoint was progression-free survival (PFS). We report results in the 271 stage IV pts; data from the 71 stage III pts will be presented when mature. Results: Baseline characteristics were well balanced. In the TEX and ET arms, respectively, 49% vs 50% had received prior chemotherapy (anthracycline in 29% of both arms); 59% vs 65% had visceral metastases; median disease-free interval was 25.0 vs 29.5 months. Median follow-up in the total population (stage IIIb and IV) at data cut-off was 27.2 and 28.4 months, respectively. With TEX, median delivered dose of X was 87% of the planned dose. 100% of planned E and T was delivered in both arms. TEX was well tolerated. In the overall population (stage IIIb and IV), there was no grade 4 diarrhea; grade 3 diarrhea and hand-foot syndrome occurred in 8% and 3% of TEX pts, respectively. Conclusions: A triple combination of three of the most active agents for BC is highly active. RR was significantly superior with TEX vs ET. Although not statistically significant, a benefit in PFS and OS (absolute difference 6.7 months) was observed with the addition of X to ET. TEX (n=136) ET (n=135) P value Response rate (RR) 67% 53% 0.02 CR 16% 5% - PR 51% 47% - PFS Events 110 (81%) 111 (82%) - Median, months (95% CI) 12.3 (11.1–15.1) 9.8 (8.4–12.9) 0.26 Overall survival (OS) Events, n (%) 71 (52%) 80 (59%) - Median, months (95% CI) 34.5 (28.2–46.5) 27.8 (22.4–42.9) 0.19 Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Eli Lilly, Hoffmann-La Roche
The Adolescent: His Conflicts and Escapes.
Authors: Sidney I. Schwab, Borden S. Veeder
Journal: JAMA (1930)

This is one of the most stimulating and valuable books on the adolescent that the reviewer has had the pleasure of reading. Its main theme is that adolescent behavior is the result of the struggle toward social and environmental adaptation. The authors have approached the problem from their respective interests. Dr. Veeder, from his interest in pediatrics, constributes the first three chapters on the physical framework of the adolescent. Dr. Schwab, as a psychiatrist, contributes the remainder of the book on the more complex situations presented by the adolescent in his struggle with his environment. The point of view presented in the whole book, however, is shared mutually. In the first chapter, Dr. Veeder discusses the physical growth and development at adolescence, but instead of beginning his discussion with puberty considers also the prepubescent period. As other authors have done, he stresses the resemblance between the growth acceleration at pubescence
Outcomes In RBC Transfusion-Dependent Patients (Pts) With Low-/Intermediate (Int)-1-Risk Myelodysplastic Syndromes (MDS) With Isolated Deletion 5q Treated With Lenalidomide (LEN): A Subset Analysis From The MDS-004 Study
Authors: Aristoteles Giagounidis, Ghulam J. Mufti, Moshe Mittelman, Guillermo Sanz, Uwe Platzbecker, Petra Muus, Dominik Selleslag, Odile Beyne-Rauzy, Peter te Boekhorst, Consuelo del Cañizo, Agnès Guerci-Bresler, Michael Lübbert, Bruno Quesnel, Arnold Ganser, David Bowen, Brigitte Schlegelberger, Tommy Fu, Bouchra Benettaib, Eva Hellström-Lindberg, Pierre Fenaux
Journal: Blood (2013)
Association Between Level of Hepatitis D Virus RNA at Week 24 of Pegylated Interferon Therapy and Outcome
Authors: Onur Keskin, Heiner Wedemeyer, Ali Tüzün, Kalliopi Zachou, Xheni Deda, George N. Dalekos, Benjamin Heidrich, Selcen Pehlivan, Stefan Zeuzem, Kendal Yalçın, Selim Gürel, Fehmi Tabak, Ramazan Idilman, Hakan Bozkaya, Michael Manns, Cihan Yurdaydin
Journal: Clinical Gastroenterology and Hepatology (2015)
Race and Vitamin D Binding Protein Gene Polymorphisms Modify the Association of 25-Hydroxyvitamin D and Incident Heart Failure
Authors: Pamela L. Lutsey, Erin D. Michos, Jeffrey R. Misialek, James S. Pankow, Laura Loehr, Elizabeth Selvin, Jared P. Reis, Myron Gross, John H. Eckfeldt, Aaron R. Folsom
Journal: JACC Heart Failure (2015)
Abstract 1390: Composition Analysis of High Density Lipoproteins in Patients with extreme HDL-C Levels with or without Ischemic Heart Disease
Authors: Amar A Sethi, Sampson Maureen, Russel Warnick, Nehemias Muniz, Boerge G Nordestgaard, Anne Tybjaerg-Hansen, Alan T Remaley
Journal: Circulation (2007)

Objective: We hypothesize that patients with high HDL-C levels and Ischemic Heart Disease (IHD) may have dysfunctional HDL or have unrecognized non-conventional risk factors. Methods: Individuals with verified IHD with either high HDL-C (n=53; female: ≥73.5mg/dL; male: ≥61.9mg/dL) or low HDL-C (n=42; female:≤38.7mg/dL; male: ≤34.1mg/dL) were compared with subjects without IHD and matched HDL-C levels (n=110). All subjects had normal LDL-C (&lt;160mg/dL) and triglyceride levels (&lt;150mg/dL) and none were treated with LDL-C-lowering medications. After removal of apoB lipoproteins, apoA-I, apoA-II, apoE, triglycerides, free cholesterol, cholesteryl ester, and phospholipids were analyzed (Cobas-Fara). HDL and LDL-subclasses were examined by linear gradient gel electrophoresis (Lipoprint®) and by Segmented Gradient Gel Electrophoresis (S-GGE). Cholesterol (RLP-C) and triglyceride (RLP-TG) content of remnant-like lipoprotein particles were measured by an immunoseparation technique. Results: Subjects with high HDL-C levels and IHD had lower apo-AI (p&lt;0.001) and cholesteryl ester (p&lt;0.01) levels compared to controls with high HDL and no IHD. Subjects with low HDL-C and IHD had lower triglyceride (p=0.01) levels compared to controls with matched HDL-C levels and no IHD. The HDL subclass, using S-GGE, with density 1.063–1.100g/ml and diameter 98 –130Å correlated with levels of HDL-C (r 2 =0.66, p&lt;0.0001). LDL subclasses using Lipoprint® exhibited higher fraction of Intermediate Density Lipoproteins (IDL-C) in patients with high HDL-C and IHD when compared with individuals with same HDL-C and no IHD (p=0.006). This was also true in the low HDL-C groups (p=0.01). This was further supported by higher levels of RLP-C and RLP-TG in individuals with high HDL and IHD (p=0.03 and p=0.03, respectively) when compared with respective controls. Conclusions: These results suggest that HDL composition rather than HDL-C levels is important in deciphering the protective role of HDL in IHD and that measurement of remnant-like lipoproteins may be useful for identifying patients with high HDL-C that are still at risk for developing IHD.
Abstract 5600: GTP Cyclohydrolase/BH4 Pathway Protects EPC Function via Suppressing Oxidative Stress and Thrombospondin-1 in Salt-Sensitive Hypertension
Authors: He-Hui Xie, Keith M Channon, Alex F Chen
Journal: Circulation (2009)

Background: Endothelial progenitor cells (EPC) are both reduced and dysfunctional in hypertension that correlates inversely with its mortality, but the mechanisms are poorly understood. eNOS critically regulates EPC mobilization and function, but is uncoupled in DOCA-salt hypertension due to reduced essential cofactor tetrahydrobiopterin (BH4). We tested the hypothesis that GTP cyclohydrolase I (GTPCH), the rate-limiting enzyme of BH4 synthesis, protects EPC function in DOCA-salt mice. Methods and Results: EPCs were isolated from peripheral blood and bone marrow of wild-type (WT), WT DOCA-salt, endothelial-specific GTPCH transgenic (Tg-GCH), DOCA-salt treated Tg-GCH, and BH4 deficient hph-1 mice. Both EPC adhesion and angiogenic functions were impaired in WT DOCA (58 and 38%, respectively, n=5– 8, p&lt;0.01) and hph-1 mice (40 and 31%, respectively, n=5–8, p&lt;0.01, vs. WT), which were rescued in DOCA Tg-GCH mice (93 and 92%, respectively, n=6–7). Superoxide (O 2 − , DHE-) and NO (DAF-FM flow cytometry) levels in EPCs were elevated and reduced, respectively, in WT DOCA (220% and 53%, respectively, n=5–12, p&lt;0.01) and hph-1 mice (280% and 41%, respectively, n=6–12, p&lt;0.05, vs. WT), which were blunted in DOCA Tg-GCH mice (137% and 96%, respectively, n=6–7). Thrombospondin-1 (TSP-1), a secreted potent anti-angiogenic protein, was elevated in EPCs of WT DOCA and hph-1 mice (290 and 280%, respectively, n=8–12, p&lt;0.01 vs. WT), but not in DOCA Tg-GCH mice (160%, n=9–12, p&gt;0.05). In vitro treatment of EPCs from WT DOCA mice with BH4, PEG-SOD, or L-NNA significantly reduced TSP-1 (51, 42 and 53%, respectively, n=5–12, p&lt;0.01) and O 2 − levels (58, 67 and 69%, respectively, n=5– 6, p&lt;0.01 vs. WT-DOCA). NO level in EPCs of WT DOCA mice was rescued by BH4 and PEG-SOD (144 and 165%, respectively, n=4–7, p&lt;0.05 vs. control), but not L-NNA. Crossing eNOS KO and Tg-GCH mice resulted in preserved circulating EPC number (88%, n=4–15, p&gt;0.05 vs. WT), reduced EPC O 2 − level (64%, n=4 – 8, p&lt;0.05 vs. WT-DOCA), and improved EPC adhesion and angiogenic functions (160 and 158%, respectively, n=4 –12, p&lt;0.05 vs. WT-DOCA). Conclusion: We demonstrate for the first time that GTPCH/BH4 pathway protects EPC function via suppressing oxidative stress and TSP-1 level in salt-sensitive hypertension. This research has received full or partial funding support from the American Heart Association, Midwest Affiliate (Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, South Dakota &amp; Wisconsin).