tbuckley/cabot-search huggingface dataset:
A phase II study of weekly irinotecan plus capecitabine for chemo-naïve patients with advanced non-small cell lung cancer
Authors: H. T. Kim, J.-Y. Han, D. H. Lee, S. Y. Lee, C. G. Park, H. Y. Kim, H. G. Lee, J. J. Lee, J. S. Lee
Journal: Journal of Clinical Oncology (2005)

7134 Background: Previously we had demonstrated the favorable activity and toxicity profile of irinotecan plus capecitabine chemotherapy in patients with previously treated non-small cell lung cancer (NSCLC). Our purpose was to evaluate the efficacy and toxicity of this non-platinum chemotherapy regimen in chemo-naive patients with advanced NSCLC. Methods: Between July 2003 and April 2004, 53 patients with histologically confirmed diagnosis of NSCLC were enrolled. All but 5 patients were male, 52 (98%) had ECOG PS 0 or 1, 39 (74%) had stage IV disease and the median age was 61 years. Treatment consisted of irinotecan 90 mg/m2 i.v., on days 1 and 8 and capecitabine 1,000 mg/m2 p.o., twice daily on days 1 through 14 of each 21-day cycle. Results: Among the 50 patients who were assessable for response, 22 responded to treatment (no complete response and 22 partial responses), for an objective RR of 44% (95% CI, 30.0% to 57.8%). After a median follow-up of 12.3 months, the median survival was 13.9 months (range, 1.5 -14.2 months) with 1-year survival rate of 64.8% (95% CI, 50.7% to 79.0%). The median PFS was 5.1months (range, < 1 to 12.4 months) and the median duration of response was 4.3 months (range, < 1 to 7.5 months). Treatment was very well tolerated, with only 10% of patients experiencing grade 3 (or 4) toxicities. Most common toxicities were hand-foot syndrome and diarrhea. There was no treatment-related death. Conclusions: Non-platinum containing irinotecan plus capecitabine regimen showed promising antitumor activity with extended 1-year survival rate for chemo-naive advanced NSCLC patients. Given the mild toxicity profile, this non-platinum regimen is recommended as the first-line therapy and also warrants further evaluation in a randomized trial. (Supported in part by NCC Grant 0210140 from National Cancer Center). No significant financial relationships to disclose.
Presentation of the John Phillips Memorial Prize
Authors: S. Marx White
Journal: Annals of Internal Medicine (1932)

Article1 July 1932Presentation of the John Phillips Memorial PrizeS. MARX WHITE, M. D.S. MARX WHITE, M. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-1-10 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Avery, Fellows of the American College of Physicians, Associates and Guests:John Phillips was born in Welland, Ontario, February 18, 1879. With a personality marked by simplicity, directness, poise and a remarkable sense of relative values, he came in the fifty years of his life to a high place in medicine in this country. Work was his philosophy of life. He exemplified this, called by Osler the Master Word. His intimate friends tell us he appeared not to know how to play. His contributions to medicine and its literature were many, and were scholarly and sound. Elected to the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: American College of Physicians*April 6, 1932. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1932Volume 6, Issue 1Page: 10-11 ePublished: 1 December 2008 Issue Published: 1 July 1932 PDF downloadLoading ...
Gould's Medical Dictionary: Containing All the Words and Phrases Generally Used in Medicine and the Allied Sciences, with Their Proper Pronunciation, Derivation and Definition.
Authors: George M. Gould, R. J. E. Scott
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Soundings: Does litigation make you ill?
Authors: Kevin Barraclough
Journal: BMJ (2001)

It's often well into the consultation when their lower lip begins to quiver. This is the physical sign that alerts us astute physicians that something is up, and that it might be a long morning. However, when they start to speak of “my case,” you know that they are suffering from WLD and you reach for the Prozac pad. There are in fact two variations of the condition: WLD—whiplash, litigation, depression—or its variant, WLBBD—whiplash, litigation, breakup with boyfriend, depression. The sequence of events from the bent bumper to the reports of the orthopaedic consultant, pain consultant, and psychiatrist stretches out with the tenuous causal certainty of a domino line.

Now I know that an association does not prove causality. However, the recurrent juxtaposition of “my case” with the quivering lower lip does give cause for thought. All I need, to label my observation “Barraclough's syndrome” (or, more modestly, to get a friend to do so), is to come up with a plausible biological mechanism for causation. Well, I can do that.

Vulnerable twenty-something (a difficult decade anyway) gets shunted in the boot at the roundabout and hurts his/her neck. A series of helpful friends, then lawyers and doctors explain that you are actually a “victim” and have “rights” to compensation. You have been “wronged” and “hurt” and you were a “helpless victim,” like some poor child napalmed in Vietnam. What is more, the amount of money you will receive increases the more severe your symptoms are, and the longer they last. As you are examined and questioned recurrently, the pain, like any prodded and examined pain, gets worse, and the sense of personal grievance against the world rises. And, to paraphrase Bertie Wooster, it's never difficult to distinguish between a litigant with a grievance and a ray of sunshine.

The trouble is that, when anything bad happens to you there are two ways you can respond. You can examine how you feel about it, the emotional and physical hurt, and the world that might have been (a dangerous place at the best of times). Or you can say “Sod it” and get on with your life. Rather worryingly, it is becoming much more lucrative to be a helpless victim than a resilient coper.

Maybe I could become an expert witness in WLD? Now there's a lucrative thought.
The Growth in Vitro of Single Isolated Tissue Cells
Authors: Katherine K. Sanford, Wilton R. Earle, Gwendolyn D. Likely
Journal: JNCI Journal of the National Cancer Institute (1948)

The Growth in Vitro of Single Isolated Tissue Cells Get access Katherine K. Sanford, Katherine K. Sanford Search for other works by this author on: Oxford Academic PubMed Google Scholar Wilton R. Earle, Wilton R. Earle Search for other works by this author on: Oxford Academic PubMed Google Scholar Gwendolyn D. Likely Gwendolyn D. Likely National Cancer Institute, National Institutes of Health, Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 9, Issue 3, December 1948, Pages 229–246, https://doi.org/10.1093/jnci/9.3.229 Published: 01 December 1948 Article history Received: 16 August 1948 Published: 01 December 1948
Abstract 12714: Early Repolarization With J-Point Elevation Predicts Mortality in the Hispanic Female Population
Authors: Eric Shulman, Philip Aagaard, Faraj Kargoli, Steve Lener, John Fisher, John Gross, Sun Kim, Eugen Palma, Luigi DiBiase, Kevin Ferrick, Andrew Krumerman
Journal: Circulation (2014)

Introduction: Early repolarization (ER) is associated with an increased risk of sudden cardiac death (SCD). However, the impact of ER may not be uniform across race and gender. An analysis from the Biracial Atherosclerosis Risk in Communities Study showed that ER was associated with SCD risk in Caucasians and highest in female Caucasians, while a study from Northern California found no association between cardiovascular mortality and ER in African Americans. Although Hispanics are the second largest segment of the population, little is known about the prevalence or prognostic implications of ER in this group. We investigated possible associations between automated ECG ER readings, defined as J-point elevation with ST segment elevation and overall mortality. Methods: ECG and EMR databases from a regional medical center from a largely Hispanic population were interrogated. Inclusion criteria included Hispanic ethnicity, age over 18 from 2000-2011. Outcomes were assessed using a Cox Proportional Hazards model with data from the Social Security Death Index. Results: There were n=34,354 Hispanics of which n=544 (1.6%) had ER. When controlling for age, gender, height/weight, systolic/diastolic BP, PR, QRS, QTc, heart rate, ejection fraction, CAD, CHF, myocardial infarction, DM, and malignancy there was no significant difference in mortality between overall subjects with and without ER (HR: 1.15, 95% CI: 0.89-1.50, p=0.294). However, significant interactions were present between gender and ER. In a multivariate regression model, ER was significantly predictive of overall mortality in females (HR: 1.91, 95% CI: 1.24-2.90, p=0.003), but not in males (HR: 0.88, 95% CI: 0.63-1.23, p=0.456) (Figure 1). Conclusions: ER is not associated with an increased risk of death in the overall Hispanic population; however, there is a higher risk of overall mortality in female population. ER may be more complex than initially suspected, which emphasizes a need for additional research.
Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery
Authors: Chung-Yin Lin, Han-Yi Hsieh, William G Pitt, Chiung-Yin Huang, I-Chou Tseng, Chih-Kuang Yeh, Kuo-Chen Wei, Hao-Li Liu
Journal: Journal of Controlled Release (2015)
421. Large-Scale Production of AAV and Adenovirus Vectors Using Active Gassing with Large Culture Vessel
Authors: Takashi Okada, Tatsuya Nomoto, Toru Yoshioka, Tsuyoshi Ogura, Takashi Matsushita, Hiroaki Mizukami, Akihiro Kume, Villy Nielsen, Keiya Ozawa
Journal: Molecular Therapy (2004)
NIH ‘glues’ cell biologists together
Authors: Alan Dove
Journal: Nature Medicine (2000)

American research into cell signaling is to benefit from the latest, large-scale National Institutes of Health (NIH) funding initiative. The National Institute of General Medical Sciences (NIGMS) has announced that its first 'glue grant'a new type of grant designed to fund projects requiring cooperation between investigators at multiple institutionswill provide an estimated $25 million over a period of five years to the Alliance for Cell Signaling, an effort to produce a detailed map of the signal transduction pathways in two types of cells, cardiomyocytes and B cells.
Endocrine Diseases Including Their Diagnosis and Treatment.
Authors: Wilhelm Falta, Milton K. Meyers
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die infantilen Zerebralparesen.
Authors: Hans Asperger, K. Lindemann
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12752: Long QT Syndrome Type 3 Caused by a PY-motif Mutation Leading to Altered Ubiquitylation and Increased Expression of Nav1.5 in Knock-in Mice
Authors: Maxime Albesa, Carol A Remme, Jean-Sebastien Rougier, Jakob Ogrodnik, Severinne Petitprez, John Bankston, Robert S Kass, Connie R Bezzina, Wendy Chung, Hugues Abriel
Journal: Circulation (2010)

Background: Congenital long QT syndrome type 3 (LQT3) is characterized by delayed repolarization leading to sudden cardiac death, and is caused by gain-of-function mutations in SCN5A, the gene enco...
The Drug Etiology of Agranulocytosis and Aplastic Anemia
Authors: David W. Kaufman
Journal: Annals of Internal Medicine (1992)

DRUG INDUCED AGRANULOCYTOSIS AND APLASTIC ANEMIA: GENERAL CONSIDERATIONS: The concept of drug safety Agranulocytosis and aplastic anemia as drug-induced diseases Evidence for the drug induction of agranulocytosis Evidence for the drug induction of aplastic anemia STRATEGIES FOR OBTAINING INFORMATION ABOUT DRUG EFFECTS: Benefit, risk, the present study THE DISEASES (by Herman Heimpel): Agranulocytosis, Aplastic anemia THE DESIGN OF THE STUDY: Objectives, definition of cases, study base, sample size estimates, methodological considerations in the collection of data METHODS: Definition and ascertainment of cases, selection of controls, data collection, data analysis THE STUDY EXPERIENCE: Origins of the study, pilot study, changes in the study population, completeness of case ascertainment, definition of onset for cases of agranulocytosis, interim analyses THE STUDY POPULATION: Agranulocytosis, Aplastic anemia, Controls, Summary INCIDENCE OF AGRANULOCYTOSIS: The study base: overall incidence, community-acquired agranulocytosis, comments INCIDENCE OF APLASTIC ANEMIA: The study base: overall incidence, incidence according to various factors, comments NONNARCOTIC ANALGESIC AND NONSTEROIDAL ANTI-FLAMMATORY DRUGS The drugs, specific methods, results, summary of results and consideration of validity, comments, conclusion ANTI-INFECTIVE DRUGS: The drugs, specific methods, results, summary of results and consideration of validity, comments, conclusion ANTITHYROID DRUGS: The drugs, specific methods, results, summary of results and considerations of validity, comments, conclusion CARDIOVASCULAR DRUGS AND DIURETICS: The drugs, specific methods, results, summary of results and consideration of validity, comments, conclusion PSYCHOTROPIC DRUGS AND ANTIHISTAMINES: The drugs, specific methods, results, summary of results and consideration of validity, comments, conclusion MISCELLANEOUS DRUGS: The drugs, specific methods, results, summary of results and consideration of validity, comments, conclusion FACTORS OTHER THAN DRUGS: Introduction, specific methods, results, summary of results and consideration of validity, comments, conclusion GENERAL CONCLUSIONS: Risk estimation for diseases with multiple causes Etiologically relevant risk intervals Regional variation of drug-induced agranulocytosis The strengths and limitations of the present study Concluding remarks. Appendices Index of Drug names.
The Effects of Inanition and Malnutrition upon Growth and Structure.
Authors: Clarence Martin Jackson
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Healing of Rodent Cancer by Electricity.
Authors: J. Inglis Parsons
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Art: Robin Levy: Confronting Our Bodies
Authors: Gavin Yamey
Journal: BMJ (2004)

The American artist Robin Levy is fascinated by the way that our bodies are changed by pregnancy, disease, and ageing, and by the way in which our bodies become “objects” when we undergo medical procedures. Many of the sculptures, installations, and photographs in her new show are snapshots of our bodily changes—as if Levy is trying to create a permanent record of something that is never quite static.

One of the techniques that she uses is to juxtapose or superimpose images of her own body with those of her son or her mother. In Vein, for example, is a series of digital photographs showing two legs that at first glance appear to belong to the same person. Look more closely at the varicose veins and you see that they are more advanced on one of the legs, which belongs to Levy's mother, and less advanced on the other leg, belonging to Levy herself. In the sculpture Self Portrait: Artist and Mother, she pairs a casting of her right foot with her mother's left foot.

This sense of our connectedness and heredity is even more obvious in Soft Spot, a photograph of Levy's thumbprint—a potent symbol of her unique identity—superimposed on to her son's birthmark. The effect is initially unsettling—how odd to see a mole bearing the familiar whorl of a fingerprint—but once you realise what you are looking at, the overall sense is of tenderness (a mother's soft spot for her child).

Levy worked closely with health professionals to create the two most striking images in the show, Lifeline #2 and Lifeline #3. These are cross sections of umbilical cords that have been digitally manipulated to produce enormous prints, in which the pink cords are tiny against a huge white backdrop. The cords appear so delicate, yet the title of the pieces reminds us of their power and of their potential therapeutic use. David Rubin, the curator of the show, says that these large scale prints “quietly take a positive stance on the potential benefits of stem cell research.”




Figure 1



In Vein #3, 2001




Many of the works that deal with health and illness reflect the artist's personal experiences. Following her own pregnancy, she created Birthing Sheet, made of crisp white cotton. The piece captures the clinical and impersonal aspects of giving birth—the sheet is there to focus the obstetrician's concentration by removing intimacy with the patient.

In the mid-1990s, Levy discovered that a family member and several friends had breast cancer and she became a carer to many of them. She has turned her experiences into a series of sculptures, including The Princess and the Pea, in which a mammogram is displayed on a pillow as if it were a precious, highly prized object (the tassels of the pillow were made from strips of mammogram film).

Confronting Our Bodies is presented in a quiet, dimly lit space. Each artwork is individually illuminated, adding to our strong sense of awe as we gaze at these representations of the human body.
Evaluation Of Myeloablative Therapy Followed By Autologous Stem Cell Transplantation In First Remission In Patients With Advanced Stage Follicular Lymphoma After Initial Immuno-Chemotherapy (R-CHOP) Or Chemotherapy Alone: Analysis Of 940 Patients Treated In Prospective Randomized Trials Of The German Low Grade Lymphoma Study Group (GLSG)
Authors: Wolfgang Hiddemann, Martin H. Dreyling, Bernd Metzner, Michael Pfreundschuh, Martin Wilhelm, Eva Lengfelder, Georg Hess, Michael Hallek, Norbert Schmitz, Christiane Pott, Thomas Fischer, Roswitha Forstpointner, Eva Hoster, Michael Unterhalt
Journal: Blood (2013)