tbuckley/cabot-search huggingface dataset:
Abstract 19644: A Biocompatible Light-Activated Adhesive for Intra- and Extracardiac Applications in Acquired and Congenital Heart Disease
Authors: Nora Lang, Maria Nunes Pereira, Ingeborg Friehs, Nikolay Vasilyev, Klemens Ablasser, Eoin O'Cearbhaill, Chenjie Xu, Haruo Yamauchi, Peter Hammer, Steve Wasserman, Jeffrey M Karp, Pedro del Nido
Journal: Circulation (2012)

Background: There is a clinical need for alternative methods for tissue to tissue and device to tissue attachments in cardiovascular surgery. Tissue adhesives offer a potential solution. However, commercially available tissue adhesives are associated with poor control over adhesion and low adhesive strength, especially in the presence of blood and under dynamic conditions. Thus, we developed a light-activated adhesive, poly(glycerol-co-sebacate) acrylate (PGSA) and evaluated its effectiveness for interventions in acquired and congenital heart disease. Methods and Results: The adhesive strength of PGSA and cyanoacrylate (CA) coated patches was evaluated in pull-off tests using fresh myocardial tissue. In the presence of blood, adhesive strength was 1.4 ± 0.6 N/cm2 and 1.6 ± 0.3 N/cm2 for PGSA and CA coated patches, respectively. In addition, the adhesive strength did not decrease in case the PGSA coated patch was immersed in a blood-filled glass dish for 5 minutes before the measurement. To evaluate the ability of PGSA to close cardiac defects, transmural left ventricular (LV) wall defects (d=2 mm) were created in a chronic in vivo rat model and closed with a biocompatible patch and PGSA (n=26). Closure with sutures only or CA was used as a control. Animals were sacrificed after 7, 28 and 60 days. Closure was successful in over 90% of the cases for all three groups. Histology revealed a good integration of the patch with minimal inflammatory reaction. In contrast, closure with CA exhibited a pronounced inflammatory response. Echocardiography reveals preservation of LV function for PGSA whereas closure with sutures led to impaired regional contractile function. In addition, surgically created incisions in the aorta (d=1 mm, n=1) and the carotid artery (d=2 mm, n=4) were successfully closed with only PGSA without bleeding and blood flow was confirmed in an acute in vivo pig model (n=3). Histology revealed intact endothelium at the curing site and no thrombi. Conclusions: Cardiovascular defects can be successfully closed with a light activated tissue adhesive in a chronic animal model. Longterm evaluation indicates superiority over closure with sutures or CA. PGSA is a promising adhesive for a variety of cardiovascular applications including devices.
Coagulase-negative Staphylococcal Endophthalmitis
Authors: Janet L. Davis, Afrodite Koidou-Tsiligianni, Stephen C. Pflugfelder, Darlene Miller, Harry W. Flynn, Richard K. Forster
Journal: Ophthalmology (1988)

The predicted sensitivities of common organisms guide initial antibiotic therapy in endophthalmitis. The authors suspected a change in the expected sensitivity of coagulase-negative staphylococci when three cases of endophthalmitis due to multiply resistant organisms failed to respond to intravitreal cefazolin and gentamicin. The authors reviewed 48 cases from 1982 to 1986, compared these with 28 cases from 1973 to 1981, they found increased resistance to gentamicin (35 versus 0%, P < 0.05) and increased resistance to methicillin (27 versus 19%). Eight cases were resistant to both antibiotics, including the three clinical failures. Final vision was unrelated to antimicrobial resistance. Since cephalosporins may be ineffective clinically against methicillin-resistant staphylococci, concomitant gentamicin resistance may render intravitreal cefazolin and gentamicin inadequate for their treatment. No isolates were resistant to vancomycin. Vancomycin and aminoglycoside, used intravitreally in the initial management of endophthalmitis, would be anticipated to provide better coverage than cefazolin and aminoglycoside for endophthalmitis due to the staphylococci, as well as for infections due to streptococcal and bacillus species.
Fire-setting behavior in the histories of a state hospital population
Authors: J L Geller, G Bertsch
Journal: American Journal of Psychiatry (1985)

Review of the records of 191 nongeriatric state hospital inpatients showed that 50 (26%) of the patients had engaged in some form of fire-setting behavior; half of this group had engaged in a single episode. As a group, persons who had engaged in fire-setting behavior were significantly more likely to have a history of nonlethal self-injurious behavior and had a significantly greater number of admissions to the state hospital. The data suggest that fire setting by any patient cannot be accurately predicted and that fire-setting behavior may be an example of destructive operant behavior.
Abstract 1498: Imbalance Among Angiotensin II Receptors, Nitric Oxide System, and Manganese Superoxide Dismutase in the Aging Kidney
Authors: Ivonne H Schulman, Ming-Sheng Zhou, Joshua M Hare, Leopoldo Raij
Journal: Circulation (2008)

Chronic kidney disease (CKD) prevalence increases with aging. We hypothesized that age-related renal injury is associated with alterations in the relative expression of angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors, nitric oxide (NO) system, and the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD). Compared to 3 month (mo) old, 24 mo male Sprague Dawley rats manifested glomerulosclerosis and interstitial fibrosis with increased TGFβ mRNA (real-time PCR, 1.2±0.07 vs. 1±0.03; P<0.05) and protein expression (Western blot) of cycloxygenase (COX)-2 (3-fold) and fibronectin (7-fold). Cortical AT1R protein expression was similar but AT2R was decreased in 24 mo (0.58±0.07 vs. 1±0.07; P<0.01), whereas medullary AT1R was increased in 24 mo (1.9±0.3 vs. 1±0.1; P<0.02) but AT2R was similar. Cortical and medullary AT1R/AT2R ratios were increased in 24 mo. Cortical endothelial NO synthase (eNOS) protein expression was similar, but medullary eNOS was decreased in 24 mo (0.5±0.02 vs. 1±0...
Abstract 3661: Equal Success, but Shorter Length of Stay, With Axial Versus Pulsatile Flow Left Ventricular Assist Devices (LVAD) as Bridge to Cardiac Transplantation (BTT): The Columbia Presbyterian Experience
Authors: Daniel B Sims, Nir Uriel, Andrea Mignatti, Basil Ramlawi, Rosie Te-Frey, Jennifer Murphy, Margaret Flannery, Kathy Idrissi, Yoshifumi Naka, Ulrich P Jorde
Journal: Circulation (2009)

Introduction: The Heartmate II (HM II), an axial flow LVAD, was recently approved for BTT therapy. Nationwide registries have indicated superior outcomes to historical data obtained with the pulsat...
Cardiac metastasis arisen from a limb grade 1 mixoid liposarcoma six years after its radical resection
Authors: P. Allione, G. Grignani, S. Aliberti, R. Vormola, G. Porrino, A. Ricchiardi, A. S. Bucci, R. Ferraris, A. Capaldi, M. Aglietta
Journal: Journal of Clinical Oncology (2005)

9062 Background: To report a case of grade 1 thigh liposarcoma that is unusual in its behaviour. Methods: Case report and literature review. Results: A 45 year old man presented with a thigh mass. In march 1997 the mass was resected and diagnosed as a grade 1 mixoid liposarcoma, deep seated, 20 x 11 cm wide. According to the Enneking criteria radical surgery was performed. He did not receive any adjuvant treatment. He did well until may 2003 when he complained of a thoracic pain followed by a syncope. He was admitted to the Emergency Department where an echocardiography showed the right atrium quite completely occupied by a mass. He underwent an opened heart removal of this mass. The final diagnosis was of a metastasis from a low-grade liposarcoma with intralesional margin. Due to the anatomic site, the patient was not eligible to either surgery or radiotherapy. He received chemotherapy consisting of ifosfamide 1 g/m2/die as a continuous infusion for 14 days every 28 (six cycles). After a follow-up of 12 months he shows NED (thoracic CT scan + angio-cardiac MRI). Conclusions: Cardiac metastases are rare in sarcomas. A series of 120 consecutive autopsies found a cardiac involvement in 12.5% (DE Hallahan JCO 1986;4:1662–9). Nevertheless, the clinical incidence seems to be lower. Since 1965, 82 cases were reported in the literature (medline) and only 16 are due to liposarcoma. In McAllister’s survey liposarcomas were less than 1%. In most cases the anatomic site precludes adequate surgery which nevertheless is the mainstay of the therapy. Criosurgery could improve local control where surgical excision can be solely intralesional. There is a substantial controversy about the role of orthotopic heart transplantation in this setting. Even less clear is, if any, the role of chemotherapy. The young age of this man prompted an “adjuvant” ifosfamide chemotherapy. A literature review will be presented. No significant financial relationships to disclose.
Abstract 14951: Aortic Stenosis In High-risk Patients Presenting Coronary Artery Disease: Conventional Or Transcatheter Strategy? A Propensity Score Analysis
Authors: Daniel Wendt, Philipp Kahlert, Markus Neuhauser, Tim Lenze, Thomas Konorza, Raimund Erbel, Heinz Jakob, Matthias Thielmann
Journal: Circulation (2011)

Objectives: Aortic valve replacement with CABG surgery is currently the standard therapy for patients with aortic stenosis (AS) and concomitant coronary artery disease (CAD). We sought to determine...
Abstract 3435: Left Ventricular Hypertrophy is Resistant to Inhibition of Expression of the R403Q Alpha-Myosin Heavy Chain Cardiac Hypertrophy-Inducing Mutant Protein
Authors: Leah Cannon, Tadeusz Marciniec, Bryony Mearns, Robert M Graham, Diane Fatkin
Journal: Circulation (2008)

Left ventricular hypertrophy (LVH) develops as a compensatory response to myocardial dysfunction due to diverse causes, but is nonetheless a major risk factor for premature cardiovascular morbidity and mortality. It is thus unclear if regressing LVH is beneficial or may worsen patient outcome. To evaluate the effects of LVH regression, we developed a transgenic mouse model in which the expression of a familial hypertrophic cardiomyopathy (FHC)-inducing mutation (R403Q alpha-MHC) can be regulated in a temporal and dose-dependent manner. In this model, transgene expression can be shut off by feeding with a tetracycline analogue (doxycycline). Serial echocardiography and histology studies were performed in a cohort of mice expressing the FHC mutant (“gene-on”) and in wildtype (WT) littermates. A second cohort of WT and 403/+ mice was randomised to placebo or doxycycline (“gene off”) from 6 (Dox6) or 20 weeks (Dox20) and evaluated at 40 weeks of age. Compared to WT littermates, “gene on” 403/+ mice showed increased LV mass, LV end-diastolic diameter (LVDD) and left atrial diameter (LAD), and reduced fractional shortening (LVFS), with changes evident from 12 weeks of age. LV sections from 403/+ mice showed typical features of FHC: myofibre disarray and interstitial fibrosis. LV mass, LV function and myocardial histology were unchanged in both male and female placebo- vs Dox6 or Dox20 mice at 40 weeks (Table 1 ). Thus, consistent with the major LV thickening in FHC humans occurring in adolescence, overexpression of R403Q for only 6 weeks is sufficient to trigger the complete LVH phenotypic response. Moreover, switching off the genetic trigger for LVH in 403/+ mice at 6 weeks (prior to overt disease manifestation) or 20 weeks (established disease) does not induce regression of LVH or exacerbate contractile dysfunction. Interventions to induce LVH regression may, therefore, need to be directed at downstream factors in hypertrophic pathways. Table 1. Echo data for male WT and 403/+ mice aged 40 weeks
The Importance of Lesbian, Gay, Bisexual, and Transgender Health in Neurology
Authors: Nicole Rosendale, S. Andrew Josephson
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Tryptophan Metabolites, Pyridoxine (Vitamin B(6)) and Their Influence on the Recurrence Rate of Superficial Bladder Cancer
Authors: D.W.W. Newling, M.R.G. Robinson, P.H. Smith, D. Byar, R. Lockwood, I. Stevens, M. De Pauw, R. Sylvester
Journal: European Urology (1995)
UN Declaration of Human Rights
Authors: P J Tomlin, A. Berlin
Journal: BMJ (1998)

Editor—The re-publication of the 1948 United Nations’ Universal Declaration of Human Rights1 is a reminder of how completely this declaration and its sister, the European Convention of Human Rights, are ignored within the NHS. 

Article 10 states that everyone is entitled to a fair and public hearing by an independent and impartial tribunal in determination of rights and obligations. Article 6 of the European convention echoes this. Yet in the past 12 years not a single doctor has had such a hearing when facing the loss of his or her rights to practise as a doctor in the NHS; this contrasts greatly with the openness of the General Medical Council. 

Article 12 states that no one shall be subjected to arbitrary interference with his correspondence, or to attacks on his honour and reputation. Suspended doctors commonly have their personal mail intercepted, opened, and forwarded only after delays. Similarly, statements about suspended doctors that may damage their reputation and that allegedly come from the health authorities often appear in the media. 

Article 19 states that everyone has the right of freedom of expression. This has not stopped health authorities from seeking the dismissal of doctors who have allegedly brought them into disrepute by expressing concern about the quality of health services or the performance of a hospital trust. 

Article 20 states that everyone has the right to freedom of peaceful assembly and association. Hospital trusts now try to ban suspended doctors from meeting or talking with colleagues in their own homes. 

Articles 23 and 24 state: “Everyone has the right ... to just and favourable conditions of work” and “Everyone has the right to rest and leisure.” The conditions under which junior doctors are expected to work rarely conform to these articles. 

Perhaps the most important articles are 8 and 28: “Everyone has the right to an effective remedy by the competent national tribunals for acts violating the fundamental rights” and “Everyone is entitled to a social ... order in which the rights ... can be fully realised.” The NHS has no such tribunal, social order, or system by which these rights can be enforced. 

The lord chancellor is seeking to incorporate the European Convention of Human Rights into British law. Perhaps all doctors should write to their members of parliament, urging that the European convention and the UN declaration also be incorporated into the NHS’s administrative rules. It is a damning criticism of the NHS that the declaration is still disregarded 50 years after it was drawn up.
Abstract 9561: Connexin43 Interacts with Voltage-Gated Sodium Channel 1.5 in the Perinexus
Authors: J. M Rhett, Joseph A Palatinus, Jane A Jourdan, Robert G Gourdie
Journal: Circulation (2011)

Rapid depolarization of the myocyte sarcolemma during the cardiac action potential (AP) is dependent on the voltage-gated sodium channel Na v 1.5. Gap junctions (GJs) are thought responsible for propagation of AP between myocardial cells. Connexin43 (Cx43) is the primary isoform of GJ subunit in the working ventricular myocardium, where it localizes at intercalated disks. Previous reports from our lab have shown that the interaction of Zonula Occludens-1 (ZO-1) with Cx43 regulates the size of GJ plaques. We have further demonstrated that this interaction regulates GJ size by governing the transition of functioning connexon hemichannels into GJ intercellular channels. Moreover, we have recently determined in epithelial cells that Cx43/ZO-1 interaction extends from the GJ to a region of nonjunctional membrane proximal to the plaque called the perinexus. Here, we examine the hypotheses that cardiac GJs are also surrounded by a perinexus and that this domain contains both connexons and other channels involved in AP generation and propagation. Using the Duolink in situ protein-protein interaction assay it is confirmed that cardiomyocytes also display perinexal Cx43/ZO-1 interactions. It is also demonstrated by analysis of connexin-connexin interaction in situ that the cardiac perinexus exhibits a high density of connexon hemichannels composed of Cx43. In a further novel result, we find that the perinexus contains Na v 1.5 complexed with Cx43, but not ZO-1. Additionally, preliminary data indicates that CT-1, an inhibitor of Cx43/ZO-1 binding, increases interaction between Na v 1.5 and Cx43 in the perinexus. Taken together, our data confirm that cardiomyocyte GJs exhibit a perinexus. The localization of Nav1.5 in the perinexus suggests that this ephapse-like domain of close sarcolemmal apposition between myocytes has assignments in AP propagation independent of the canonical electrotonic pathway.
Abstract 2419: Ultrasound Velocity Criteria for Carotid In-Stent Restenosis
Authors: Yung-Wei Chi, Christopher J White, Ali Morshedi, Corey K Goldman
Journal: Circulation (2006)

Background: Carotid artery stenting is an alternative to surgery in the treatment of carotid stenosis, and as a result, in-stent restenosis (ISR) will be encountered more frequently. Duplex ultraso...
Abstract 9842: Bone Morphogenetic Protein-2 Decreases MicroRNA 30b-c to Promote Vascular Smooth Muscle Cell Calcification
Authors: Joshua A Balderman, Hae-Young Lee, Joseph Loscalzo, Jane A Leopold
Journal: Circulation (2011)

Bone morphogenetic protein-2 (BMP2) initiates vascular smooth muscle cell (SMC) calcification by upregulating expression of the osteoblast transcription factor Runx2. MicroRNAs (miRs) are negative regulators of gene expression; however, the role of miRs in regulating Runx2 expression remains unknown. Accordingly, we treated human coronary artery SMC with BMP-2 (100 ng/ml), and confirmed a 13-fold (p&lt;0.01) increase in Runx2 mRNA levels at 4 h and a 1.7-fold (p&lt;0.02) increase in protein at 24 h. A miR microarray revealed that BMP2 decreased miR-30 family expression 5.1-fold (p&lt;0.01), and real-time PCR verified this finding: BMP2 decreased expression of miR-30b by 4.4-fold (p&lt;0.01) and miR-30c by 3.4-fold (p&lt;0.01). Downregulation of miR-30b-c by transfection of SMC with anti-miR-30b-c increased Runx2 protein by 1.9-fold (p&lt;0.01) or 3.0-fold (p&lt;0.01), respectively. By contrast, forced expression of miR-30b-c by transfection with pre-miR-30b-c attenuated BMP2-induced expression of Runx2 (1 ± 0 vs. 0.6 ± 0.3 vs. 0.5 ± 0.2 arb units, p &lt;0.02). Next, we cotransfected COS7 cells with a luciferase reporter plasmid containing the Runx2 3' untranslated region (UTR) and pre-miR-30b-c. In this assay system, forced expression of miR-30b-c decreased luminosity (1.0 ± 0 vs. 0.6 ± 0.1 vs. 0.6 ± 0.1 fl. units, p&lt;0.04) indicating that miR-30b-c bind to the Runx2 3'-UTR to modulate expression. Downregulation of miR-30b-c also increased expression of the Runx2-dependent calcification protein osteocalcin (1.0 ± 0 vs. 1.7 ± 0.5 vs. 2.2 ± 0.4 arb. units, p&lt;0.03). Von Kossa staining of SMC transfected with anti-miR-30b-c for 14 d revealed that SMC calcification was increased by 1.7-fold (p&lt;0.03) or 1.8-fold (p&lt;0.03) while forced expression of miR-30b-c prevented calcification (1.2 ± 0 vs. 0.9 ± 0.1 vs. 0.9 ± 0.1 arb units, p&lt;0.01). In BMP2-treated SMC, downregulation of miR-30b or miR-30c increased calcification 1.7± 0.3-fold (p&lt;0.03) or 2.3 ± 0.7-fold (p&lt;0.03) while forced expression of miR-30b-c prevented calcification (0.9 ± 0.1 vs. 1.0 ± 0.1 vs. 1.0 ± 0.1 arb units, p&lt;0.01). These data demonstrate that miR-30b-c regulate Runx2 expression to influence SMC mineralization, and suggest that strategies to regulate expression of these miRNA may limit vascular calcification.
A national target for reducing suicide
Authors: M Abas, M J Crawford, R. Colgate
Journal: BMJ (1999)

Laparoscopic versus open mesh repair of inguinal hernia For most patients hernias provoke minimal symptomsEditor-In Wellwood et al's trial of laparoscopic hernia repair versus open mesh repair only patients fit for general anaesthesia were preselected. 1 We do not know if the rejected patients were suitable for local anaesthesia, which is usually ideal for frail and elderly patients and those with high American Society of Anesthesiologists grades.The type of anaesthesia used greatly affects morbidity associated with elective hernia repair. 2 As the authors report, after laparoscopic repair with general anaesthesia, patients may have postoperative nausea, vomiting, and retention of urine.Disorientation and cognitive dysfunction may occur with elderly patients after general anaesthesia but are rare after local anaesthesia.In Wellwood et al's trial postoperative discomfort after laparoscopic repair was reduced slightly, but does it matter?Assessment of postoperative pain is difficult, but elderly patients commonly experience less pain and require less analgesia than young adults after open hernia repair.This might be attributed to the loss of neurones with ageing 3 combined with the decrease in muscle bulk.Although laparoscopic repair is more expensive, many people have suggested that there are economic benefits of early return to work.In reality this is not so: patients over 60 are unlikely to be engaged in the labour market, so there is minimal benefit.For elderly patients, who represent half of most series, whether laparoscopic repair offers any benefits at all remains to be proved.Even with rapid recovery most employees expect a traditional amount of time off, whereas self employed patients tend to return to work as soon as possible despite any slight discomfort.The ability and desire to return to work are subjective and greatly influenced by personal circumstances.Laparoscopic repair is a more complex invasive procedure, and catastrophic complications may occur 4 ; these are unheard of with open repair.In a statistical sense the non-occurrence of an adverse event in a surgical series, as reported in this trial, does not mean that it cannot happen.Major complications from the pneumoperitoneum, bowel and vascular perforation, and acute and delayed intestinal obstruction do occur.For most patients a hernia is a benign lump that provokes minimal symptoms.Why expose patients to the major risks of a laparoscopic approach when there are marginal differences in outcome compared with open mesh repair under local anaesthesia, especially when open mesh repair is technically simple, is easily learnt, has consistent results, and is safer and cost effective?