SEVERE BONE-MARROW DEPRESSION FOLLOWING ARSPHENAMINE; REPORT OF TWO CASES WITH RECOVERY
Authors: Abraham Lieberson, Arthur Weiss
Journal: Annals of Internal Medicine (1937)

Article1 June 1937SEVERE BONE-MARROW DEPRESSION FOLLOWING ARSPHENAMINE; REPORT OF TWO CASES WITH RECOVERYABRAHAM LIEBERSON, ARTHUR WEISSABRAHAM LIEBERSONSearch for more papers by this author, ARTHUR WEISSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-12-1775 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe authors delayed reporting the following two cases of arsphenamine bone-marrow depression for several years in order to make certain of the permanency of the recovery which occurred in both cases. The blood dyscrasias occasionally caused by arsphenamine have been reported in the literature mainly under the headings of their outstanding clinical manifestations, such as granulocytopenia, agranulocytosis, thrombocytopenia, or aplastic anemia. A study of these reports and of the two patients who were followed carefully on the wards of Beth Israel Hospital has confirmed our belief that most cases may best be considered as early or late instances of the...Bibliography1. WEISSGOLDBLOOM MAAA: Dysplastic granulocytemia, Am. Jr. Clin. Path., 1932, ii, 229. CrossrefGoogle Scholar2. WHEELIHAN RY: Granulocytic aplasia of the bone-marrow following the use of arsenic, Am. Jr. Dis. Child., 1928, xxxv, 1024. Google Scholar3. SANTESSON CG: Über chronische Vergiftungen mit Steinkohlentheerbenzin, vier Todesfälle, Arch. f. Hyg., 1897, Bd. 31, 336. Google Scholar4. SELLING L: A preliminary report of some cases of purpura hemorrhagica due to benzol poisoning, Bull. Johns Hopkins Hosp., 1910, xxi, 33. Google Scholar5. FRANK E: Aleukia haemorrhagica. Aplastische (aregenerative) Anämie—Panmyelophthisie, Berl. klin. Wchnschr., 1915, Bd. 52, 961. Google Scholar6. LABBÉLANGLOIS MS: Purpura hémorrhagique aigu par intoxication arsénicale, Bull. et mém. Soc. med. d. hôp. de Paris, 1919, xliii, 786. Google Scholar7. MOOREKEIDEL JEA: Stomatitis and aplastic anemia due to neoarsphenamine, Arch. Dermat. and Syph., 1921, iv, 169. CrossrefGoogle Scholar8. FEINBERG SM: Aplastic anemia following neoarsphenamine, Jr. Am. Med. Assoc., 1922, lxxviii, 888. Google Scholar9. DODDWILKINSON KSJ: Severe granulocytic aplasia of the bone-marrow, Jr. Am. Med. Assoc., 1928, xc, 663. CrossrefGoogle Scholar10. KENNEDY WR: Occurrence of blood dyscrasias following the administration of neoarsphenamine, Canadian Med. Assoc. Jr., 1928, xix, 439. Google Scholar11. FARLEY DL: Depressed bone-marrow function from the arsphenamines, Am. Jr. Med. Sci., 1930, clxxix, 214. CrossrefGoogle Scholar12. STEPHENS DJ: Aplastic anemia occurring during the treatment of syphilis with the arsphenamines, Am. Jr. Syph., 1931, xv, 333. Google Scholar13. MCCARTHYWILSON FPR: Blood dyscrasias following arsphenamines, Jr. Am. Med. Assoc., 1932, xcix, 1557. CrossrefGoogle Scholar14. HAMILTON A: Benzene (benzol) poisoning, Arch. Path., 1931, xi, 434, 601. Google Scholar15. HELDLIEBERSON IWA: The blood dyscrasias in occupational diseases. (In press.) Google Scholar16. JACKSONPARKERRINEHARTTAYLOR HFJFFH: Studies of diseases of the lymphoid and myeloid tissues, Jr. Am. Med. Assoc., 1931, xcvii, 1436. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication January 9, 1937.From the Medical Service of Dr. Isidore W. Held, Beth Israel Hospital, New York City. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAGRANULOCYTOSIS AND APLASTIC ANÆMIA AFTER ARSPHENAMINES 1 June 1937Volume 10, Issue 12Page: 1775-1787KeywordsAplastic anemiaBloodMedical services ePublished: 1 December 2008 Issue Published: 1 June 1937 PDF downloadLoading ...