tbuckley/cabot-search huggingface dataset:
Abstract 2188: Imbalance In The Mmp timp-system And Myocardial Fibrosis In Patients With Inflammatory Cardiomyopathy
Authors: Susanne Rutschow, Olga Lettau, Sebastian Jaeger, Matthias Bock, Kerstin Puhl, Uwe Kuehl, Michael Noutsias, Heinz P Schultheiss, Matthias Pauschinger
Journal: Circulation (2007)

Introduction: Inflammation and/or viral infection are both relevant for extracellular matrix remodeling. Therefore the effects of myocardial inflammation on ECM remodeling are analyzed in this study. # Methods and results: Endomyocardial biopsies were obtained from 20 patients with established DCM (2.11±0.44 CD3 cells/mm 2 ) and 29 DCMi patients (18.91±6.41 CD3 cells/mm 2 ) comparable in age (51.45±3.15 vs. 48.48±2.39 years), LVEDD (72.7±2.2 vs. 69.76±1.06mm) and EF (26±2.99 vs. 25.86±2.0%). Total collagen content was quantified by picosiriusredstaining while the MMP2, MMP3 and TIMP1 expression was evaluated by immunohistochemistry. The MMP1, MMP3 and TIMP1 and ICTP expression in the serum was quantified by Elisa. and levels of IL6 and IL8 were measured by BioPlexAssays. Furthermore various cytokines and proteases were evaluated by real-time-PCR. In DCMi patients both CD3-lymphocyte infiltration (8.95fold, p&lt;0.001) and IL6 expression (2.93fold, p=0.0067) were significantly increased vs. DCM as well as the mRNA-expression of TNF-alpha (p&lt;0,049). The cellular inflammation correlated with the grade of fibrosis (p&lt;0.01) which is 2.43fold elevated in DCMi (p&lt;0.01). This may be caused by the increased MMP expression in DCMi, demonstrated by elevated MMP1 serum level (1.64fold increased, p&lt;0.01 vs. DCM) and slightly increased MMP-2 (1.41fold) and MMP-3 (1.6fold) expression in biopsies. In contrast, the serum levels of TIMP1 were reduced to 83.14% in DCMi (p=0.06 vs. DCM) and correlated negatively to the serum MMP3 expression (p&lt;0.01) indicating an imbalance in the proteasessystem. The transcripts amount of collagen type I (ρ = −0.80; P &lt;0.0091) and III (ρ = −0.80; P &lt;0.0091), inflammatory cytokines TGF beta (ρ =−0.67; P &lt;0.044) and INF beta (ρ = −0.47; P &lt;0.05) as well amount of ICTP (ρ = −0.89; P &lt;0.0011) was positively correlated with decreased LVEF from DCMi patients. The increased number of CD3 active cells in DCM biopsies was positively linked to the protein amount of TIMP1 as well to the mRNA amount of MMP9. Conclusion: Myocardial inflammation in patients with DCMi leads to an imbalance in the MMP/TIMP-system, which attributes to the development of myocardial fibrosis.
Abstract 13625: High Glucose Enhances Vascular Responses to Thrombin via Protease-activated Receptor-4 Upregulation in Human Vascular Smooth Muscle Cells.
Authors: Seema Dangwal, Bernhard H Rauch, Karsten Schror, Anke C Rosenkranz
Journal: Circulation (2010)

Diabetes is associated with vascular remodeling, inflammation and enhanced thrombin generation. Thrombin, in addition to its coagulatory actions, promotes vascular smooth muscle cell (SMC) mitogene...
Abstract 12118: Regenerative Potential Of P53 Silenced Human Endothelial Progenitor Stem Cells (hEPCs) In Diabetes
Authors: Sabyasachi Sen, Mary Young, Xiaoling Hill, Jeff Kane, Joseph D Jerry
Journal: Circulation (2010)

Literature shows that peripheral blood derived EPCs can be matured to adult EC, however senescence of EPCs in high glucose (HG) is also known to occur, which may reduce the number of EPCs leading t...
Abstract 3741: Stress Promotes Arterial Thrombosis through Activation of the Sympathetic Nervous System
Authors: Simon F Stampfli, Giovanni G Camici, Irene Garcia, Thomas F Luscher, Felix C Tanner
Journal: Circulation (2008)

Background: Several lines of evidence demonstrate a correlation between stress and cardiovascular mortality and morbidity. Myocardial infarction can be triggered by life threatening events such as earthquakes or missile attacks, and even every day stressful situations such as anger were shown to correlate with adverse cardiovascular events, primarily caused by arterial thrombus formation. The sympathetic nervous system is known to mediate various stress-related effects; however, a mechanism linking stress and thrombosis has not been described. Methods: To investigate the influence of acute stress on arterial thrombosis, mice were subjected to a restraint stress protocol for 20 hours. Subsequently, arterial thrombosis was induced by photochemical injury in vivo . Furthermore, coagulation times (PT, aPTT) and tissue factor activity were assayed in plasma and carotid artery, respectively. In addition, tail bleeding time was assessed. To investigate the role of the sympathetic nervous system, chemical sympathectomy was performed by treating mice with 6-Hydroxydopamine (OHDA) or control vehicle, respectively. Results: Time to thrombotic occlusion was significantly decreased in stressed mice as compared to controls (−26.7 ± 4.0 minutes, p&lt;0.001, n=5). In sympathectomized mice stress failed to decrease time to occlusion (−8.1 ± 5.6 minutes, n.s., n=5); Sympathectomy alone had no effect on time to occlusion as compared to vehicle treatment. Tissue factor activity, tail bleeding time, and coagulation times remained unchanged under all conditions, indicating an unaltered state of vessel wall tissue factor, systemic coagulation and platelet function, respectively. Conclusions: Stress enhances arterial thrombosis via the sympathetic nervous system. The link between increased sympathetic activity and thrombus formation is still under investigation. These findings may open novel perspectives for the understanding of stress-induced cardiovascular events.
Stroke units
Authors: S. Stone
Journal: BMJ (2002)

Stroke is a worldwide problem with high incidence, mortality, disability rates, and costs. 1 2 Stroke units are knownto improve outcome by concentrating patients in a unit with appropriate expertise.3 The United Kingdom has some of the worst outcomes for stroke.2 With a national service framework laying out milestones for the NHS to deliver a better service by April 2004,4 the publication ofthe third national sentinel stroke audit for 2001-2 by the Royal College of Physicians is welcome, as it gives an overview of progress to date.5

Unfortunately, it makes for desolate reading. Two hundred and thirty five hospitals participated in this audit of the organisation and processes of stroke care. The outstanding feature of the report is the failure of the NHS to provide adequate numbers of beds in stroke units. Although the mean number of patients with stroke in hospitals on a specific day was 30, the mean number of acute stroke beds was four and the median number zero. For rehabilitation beds for stroke the mean number was 15 and the median 14. From this lack of capacity to admit patients flows most …
Abstract 5098: Clinical Presentation and Outcome of Early Postoperative Myocardial Infarction in Elderly Patients Following Hip Fracture Surgery
Authors: Bhanu Gupta, Jeanne M Huddleston, Lisa L Kirkland, Paul M Huddleston, Larson R Dirk, Rachel E Gullerud, Jensen R Matthew, R Scott Wright
Journal: Circulation (2009)

Background: Patients suffering post operative myocardial infarction (PMI) have higher mortality and morbidity rates than observed with non-PMI subsets. Little is known about the true incidence of PMI and how PMI differs from non-PMI with regard to clinical presentation, management and outcome. Methods: We examined the incidence and outcomes of patients with PMI in 1212 subjects (≥65 years) undergoing hip fracture surgery from 1988 – 2002 using a population-based retrospective cohort study from the Rochester Epidemiology Project in Olmstead County, Minnesota. PMI was defined on the basis of cardiac biomarker and/or electrocardiographic evidence of definitive MI within 7 days post operatively. Results: PMI occurred in 170 (14.0%) patients yet only 36 (21.2 %) patients had one or more clinical symptoms suggesting coronary ischemia. One or more classic symptoms of myocardial infarction were present in 26 (15.3%) including shortness of breath (SOB) in 18 (10.6%), chest/arm pain in 11 (6.5%), nausea/vomiting in 8 (4.7%) and diaphoresis in 1 (0.6%). Delirium was present in 15 (8.8%) patients. Median hospital length of stay was longer (10.0 vs. 8 days, p&lt;0.01) and the in-hospital mortality rate was significantly higher (14.1% vs. 1.6%, p&lt;0.001) among patients who had PMI within 7 days. Conclusion: The clinical presentation of PMI differs from non-PMI in the elderly undergoing hip fracture surgery. Most patients were asymptomatic or had atypical clinical presentations. We observed a significantly higher rate of hospital mortality among those experiencing a PMI. Further studies are necessary to better understand the presentation, optimal management and prevention of PMI. Table 1. Study Population Table 2. Clinical Presentation and Outcomes in Patients with and without Post Operative MI This research has received full or partial funding support from the American Heart Association, National Center.
TNT009, a Classical Complement Pathway Specific Inhibitor, Prevents Complement Dependent Hemolysis Induced By Cold Agglutinin Disease Patient Autoantibodies
Authors: Sandip Panicker, Ju Shi, Eileen Rose, Sami Hussain, Susan Tom, William Strober, Steven R. Sloan, Graham Parry, Nancy Stagliano
Journal: Blood (2013)
Abstract 19227: Left Ventricular Lead Implantation for Cardiac Resynchronization Therapy is Facilitated by Three Dimensional Rotational Venography of the Coronary Sinus Tree
Authors: Stephan Goetze, Mattias Roser, Ji-Hong Gerds-Li, Eckart Fleck
Journal: Circulation (2010)

Cardiac resynchronization therapy (CRT) requires optimal visualization of the coronary sinus (CS), its tributaries and their threedimensional localization for successfull lead placement. Preoperative knowledge of the CS anatomy facilitates catheter-based intubation of the CS, target vein and lead selection and reduces the need for fluoroscopy, contrast medium and overall procedure time. 3-dimensional rotational angiography (3DRA) provides a new means of multiangle imaging of the CS tree that can be applied preoperatively in the cath lab. Our study aims to investigate the feasibility of preoperative rotational CS venography and its implications on CRT implantation procedures. For this purpose, CS-visualization for CRT implantation was done either conventionally with retrograde CS-venography and standard fluoroscopic views (SFV, n = 30), or with antegrade CS-imaging via contrast medium injection (15 ml) into the left coronary artery using 3DRA in the venous phase of contrast flow (3DRA, n = 30). 3DRA succes...
Abstract 16298: Importance of Event vs. Nonevent Weighting and Baseline Risk Assessment in Risk Reclassification for Heart Failure: The Cardiovascular Health Study
Authors: Andreas P Kalogeropoulos, Vasiliki V Georgiopoulou, Christopher R deFilippi, John S Gottdiener, Javed Butler
Journal: Circulation (2011)

Background: Net reclassification improvement (NRI), considers any correct upward movement of events and downward movement of nonevents (in terms of assigned risk) as model improvement. In the origi...
Abstract 5444: Cbx3 Identified by Nuclear Proteomics Plays a Key Role in Stem Cell Differentiation Into Smooth Muscle Cells in vitro and in vivo
Authors: Qingzhong Xiao, Gang Wang, Xue Bai, Xiaoke Yin, Manuel Mayr, Xian Wang, Qingbo Xu
Journal: Circulation (2009)

Our previous studies demonstrated that Sca-1+ progenitors derived from embryonic stem cells (ESCs) and adventitial tissues of adult apoE−/− mice can differentiate into smooth muscle cells (SMCs) that participated in the neointimal formation. However, the molecular mechanism of stem cell differentiation into SMCs is not fully elucidated. To identify potential signal transducers mediating SMC differentiation, nuclear proteins were harvested from undifferentiated mouse ESCs and differentiating ESC at different time points, and subjected to proteomic analysis by nanoflow liquid chromatography tandem mass spectrometry. We found that the majority of upregulated nuclear proteins during SMC differentiation were involved in chromatin remodeling, cell proliferation, and RNA processing processes. Among those upregulated nuclear proteins, we further focused on chromobox protein homolog 3 (Cbx3) because Cbx3 functions as activator and/or repressor within both heterochromatin and euchromatin. Knockdown of Cbx3 in the differentiating stem cells resulted in down-regulation of smooth muscle markers including smooth muscle actin, SM22, calponin and smooth muscle myosin heavy chain, while enforced expression of this gene enhanced SMC differentiation in a dose-dependent manner. CHIP assay suggests that Cbx3 mediated SMC differentiation through regulation of smooth muscle specific transcription factor, serum response factor (SRF), and coactivatior myocardin. Furthermore, we also demonstrated that the transcription factor, Dia1, functioned as a bridge protein between Cbx3 and SRF, through which Cbx3 modulates SRF activation, mediates ultimately SMC differentiation. Interestingly, in situ hybridization and immunohistochemical staining indicates that Cbx3 localized at smooth muscle system during development in different stages of chicken embryos. Importantly, in vivo knockdown of Cbx3 in the vessel wall significant increased wire-injury-induced neointima formation in mice. Our findings demonstrated for the first time that Cbx3 has a crucial role in SMC differentiation and possesses a protective function in vessel injury-induced neointima formation, providing novel information on potential therapeutic targets for vascular diseases.
Abstract 1836: Usefulness of Unipolar Electrical Recordings in the Coronary Sinus during Atrial Fibrillation for Differentiation of Coronary Sinus and Left Atrial Potentials
Authors: Sonoko Ashino, Yasuo Okumura, Kimie Ohkubo, Kenichi Hashimoto, Masayoshi Kofune, Kazunori Kawauchi, Atsushi Shindo, Hidezou Sugimura, Toshiko Nakai, Satoshi Kinimoto, Satoshi Saito, Atsushi Hirayama
Journal: Circulation (2007)
Abstract 1374: Impairment of JNK-IRS-1 Signaling Cascades and Cardiac Function in Fetal Heart During Overnourished Obese Sheep Pregnancy
Authors: Jingying Wang, Heng Ma, Peng Zhao, Jun Ren, Stephen P Ford, Peter W Nathanielsz, Ji Li
Journal: Circulation (2009)

Obese pregnant mothers may expose their children to high risk of Type 2 diabetes and myocardial hypertrophy. We hypothesize that alterations in cardiac signaling pathways and cardiac function may o...
Micronutrient Deficiencies
Authors: Victor Soukoulis, Jamil B. Dihu, Michael Sole, Stefan D. Anker, John Cleland, Gregg C. Fonarow, Marco Metra, Evasio Pasini, Theresa Strzelczyk, Heinrich Taegtmeyer, Mihai Gheorghiade
Journal: Journal of the American College of Cardiology (2009)
Abstract 16760: Evidence of Variability Of 2D Strain Measures in Human Subjects Referred for Routine Echocardiographic Examination
Authors: Visali Kodali, Samir K Saha, Rena S Toole, Ebere O Chukwu, Satish C Govind, Anatoli Kiotsekoglou, Lars-Ake Brodin, Aasha S Gopal
Journal: Circulation (2010)

Purpose: Study of myocardial mechanics is of great importance in a wide range of clinical situations. Recent advances in echocardiographic post-processing methods to quantify myocardial mechanical ...
High levels of lymphoid expression of enhanced green fluorescent protein in nonhuman primates transplanted with cytokine-mobilized peripheral blood CD34+ cells
Authors: Robert E. Donahue, Robert P. Wersto, James A. Allay, Brian A. Agricola, Mark E. Metzger, Arthur W. Nienhuis, Derek A. Persons, Brian P. Sorrentino
Journal: Blood (2000)
Racial and Ethnic Disparities in Health Care
Journal: Annals of Internal Medicine (2004)

Disparities clearly exist in the health care of racial and ethnic minorities. This position paper of the American College of Physicians (ACP) provides ample evidence illustrating that minorities do not always receive the same quality of health care, do not have the same access to health care, are less represented in the health professions, and have poorer overall health status than nonminorities. The ACP finds this to be a major problem in our nation's health system that must be addressed. The ACP is dedicated to working toward eliminating all disparities in health care. This position paper sets forth specific positions for reducing these disparities and will be the foundation for public policy advocacy by ACP for eliminating racial and ethnic disparities in health care.
Cost, utilization, and utilization review of mental health services in a prepaid group practice plan
Authors: S S Goldensohn
Journal: American Journal of Psychiatry (1977)

The author describes the utilization review process, utilization patterns, and service cost of the Mental Health Service of the Health Insurance Plan of Greater New York (HIP). He finds that a mental health care delivery system within a health maintenance organization offers the advantages of sophisticated utilization review procedures, reduced cost per mental health incident, and a low utilization rate and low cost for psychiatric hospitalization. However, the HMO's return-to-function treatment goals may be too limited for the minority of patients who would benefit only from long-term intensive treatment. He recommends that cost accounting be based on cost per illness rather than cost per service.
ACC/AHA 2007 Methodology for the Development of Clinical Data Standards
Authors: Martha J. Radford, Paul A. Heidenreich, Steven R. Bailey, David C. Goff, Frederick L. Grover, Edward P. Havranek, Richard E. Kuntz, David J. Malenka, Eric D. Peterson, Rita F. Redberg, Veronique Lee Roger
Journal: Circulation (2007)
Imetelstat, a Telomerase Inhibitor, Induces Morphologic and Molecular Remissions In Myelofibrosis and Reversal Of Bone Marrow Fibrosis
Authors: Ayalew Tefferi, Kebede Begna, Rebecca R. Laborde, Mrinal M Patnaik, Terra L Lasho, Darci Zblewski, Christy Finke, Lauren Schimek, Betsy R. LaPlant, Curtis A. Hanson, Monic J. Stuart, Animesh Pardanani
Journal: Blood (2013)
Abstract 3085: Pre-stenting with a Bare Metal Stent before Percutaneous Pulmonary Valve Implantation Reduces the Risk of Stent Fractures
Authors: Johannes Nordmeyer, Philipp Lurz, Alexander Jones, Sachin Khambadkone, Andrew M Taylor, Philipp Bonhoeffer
Journal: Circulation (2008)

Background: Stent fractures are the most common complication after percutaneous pulmonary valve implantation (PPVI), with an incidence of 20%. In a third of these cases, stent fractures lead to recurrent right ventricular outflow tract (RVOT) obstruction and required re-intervention. A previous risk factor analysis indicated that a more rigid implantation site prevented this complication. We sought to analyze, whether pre-stenting with a bare metal stent (BMS) could reduce the incidence of stent fractures after PPVI. Methods: Between September 2005 and June 2008, we studied 108 consecutive PPVI patients (PPVI only: n=54; BMS + PPVI: n=54). All patients underwent biplane chest X-ray, echocardiography and clinical evaluation during protocolized follow-up (1, 3, 6 and 12 months post procedure and yearly thereafter). The primary endpoint was PPVI stent fracture of any type. Data on the previously identified risk factors for stent fractures were collected in all patients. Hazard ratios (HR) were calculated from a multivariate Cox regression analysis. Subsequently, probabilities for the primary endpoint were obtained from a logistic regression model. Results: In this series, the overall incidence of stent fractures was 14/108 (13%). Two factors were associated with a lower incidence of stent fractures: pre-stenting with BMS (HR 0.22, P =0.03) and calcifications along the implantation site (HR 0.19, P &lt;0.01); one factor was associated with a higher incidence of stent fractures: recoil of PPV during balloon deflation (HR 16.3, P &lt;0.01). According to these factors, performing pre-stenting with BMS could reduce the probability of developing stent fractures after PPVI in all patients, with the effect size depending on the individual risk profile. In the group with the lowest risk (i.e. presence of RVOT calcifications and no PPV recoil), the risk could be reduced by 6% (from 7% to 1%), in the low-risk group by 24% (from 31% to 7%), in the medium-risk group by 40% (from 65% to 25%) and in the group with the highest risk (i.e. no RVOT calcifications and PPVI recoil) by 26% (from 91% to 65%). Conclusions: Pre-stenting with BMS is associated with a lower incidence of stent fractures after PPVI and may represent a clinically applicable strategy to improve patient outcome.
Long-Term Outcomes of Older Diabetic Patients After Percutaneous Coronary Stenting in the United States
Authors: William B. Hillegass, Manesh R. Patel, Lloyd W. Klein, Hitinder S. Gurm, J. Matthew Brennan, Kevin J. Anstrom, David Dai, Eric L. Eisenstein, Eric D. Peterson, John C. Messenger, Pamela S. Douglas
Journal: Journal of the American College of Cardiology (2012)
The psychotherapist as witness for the prosecution: the criminalization of Tarasoff
Authors: G B Leong, S Eth, J A Silva
Journal: American Journal of Psychiatry (1992)

The "duty to protect" doctrine heralded by the Tarasoff decision seeks to prevent physical harm to third parties by psychiatric patients. Recent court cases have mandated the testimony of a criminal defendant's psychotherapist both about the Tarasoff warning itself and about confidential treatment information that was associated with the warning. One court further ruled that some clinical sessions were not psychotherapy and therefore were not afforded the protection of psychotherapist-patient privilege. The continuing erosion of confidentiality has resulted in psychiatrists and other mental health professionals becoming prosecution witnesses at the criminal trials of their own patients.
Abstract 48: AVE4454 (a New NHE-1 Inhibitor) Administered During Resuscitation from VF Ameliorates Post-Resuscitation Myocardial Dysfunction
Authors: Julieta D Kolarova, Iyad M Ayoub, Sufen Wang, Jeejabai Radhakrishnan, Domenico M Taglieri, Raul J Gazmuri
Journal: Circulation (2006)