tbuckley/cabot-search huggingface dataset:
Clinical outcomes of a phase I/II study of stereotactic radiotherapy for metastatic lung cancer
Authors: Y. Nagata, M. Hiraoka, Y. Norihisa, K. Takayama, Y. Matsuo, T. Mizowaki, M. Sakamoto
Journal: Journal of Clinical Oncology (2006)

17081 Background: The clinical significance of three-dimensional stereotactic radiotherapy (SRT) for primary lung cancer has been demonstrated by a few studies. This study was performed to evaluate the clinical outcomes of SRT for treating metastatic lung cancer using a stereotactic body frame. Methods: Of the forty-one patients who were treated between October 1998 and December 2004, thirty-four patients were evaluated in this study. All patients had less than two lung solitary metastases without any other metastases and primary recurrence. Fifteen patients were metastasis from primary lung cancer. The other 9 had metastasis from colo-rectal cancer, 5 from head and neck cancer, 3 from renal cancer, 1 from breast cancer, 1 from osteosarcoma of femur. All tumor size was less than 4 cm in diameter. Three-dimensional treatment planning using 5 to 8 non-coplanar beams was performed to maintain the target dose homogeneity and to decrease the irradiated lung volume &gt;20 Gy. All patients were irradiated using a stereotactic body frame and 18 received 4 single 12 Gy, 16 recieved 5 single 12Gy of radiation at the isocenter over a period of 4–18 (median = 12) days. Results: Four patients (4/34%) completely disappeared after treatment (CR) and nine (9/34%) decreased in size by 30% or more (PR), eighteen had no tumor progression in clinically (SD). Three had progress disease (PD). Twenty-eight (82%) of 34 tumors were locally controlled during the follow-up period. Local recurrences and new metastase occurred in one and six of lung cancer patients, one and three of colo-rectal cancer patients, respectively. For recurrent primary lung cancer, the overall survival rates after one and three years were 100 and 63%, respectively, while for secondary lung cancer from colorectal cancer, the overall survival rates were 100 and 71%, respectively. During the follow-up of 10.5–80.6 (median = 27.3) months, no pulmonary complications greater than an CTC-AE V3.0 criteria of grade 4 were noted. Conclusions: Sterotactic radiotherapy using a stereotactic body frame was useful for the treatment of metastatic lung tumors. No significant financial relationships to disclose.
Abstract 16474: BP Reduction With the Sodium Glucose Co-Transporter 2 Inhibitor Empagliflozin in Type 2 Diabetes is Similar in Treatment Naïve as in Those on One or ≥ 2 Antihypertensive Agents - Further Insights From a Dedicated 24h ABPM Study
Authors: Guiseppe Mancia, Christopher P Cannon, Illka Tikkanen, Cordula Zeller, Ludwin Ley, Thomas Hach, Hans-Juergen Woerle, Uli C Broedl, Odd Erik Johansen
Journal: Circulation (2014)

In patients with type 2 diabetes (T2D) hypertension is accompanied by an increase in CV risk which can be substantially attenuated if BP is lowered by drug treatment. Empagliflozin (EMPA) is a new glucose-lowering agent of the sodium glucose co-transporter 2 inhibitor (SGLT2i) class, which has been shown to reduce body weight and also lower BP. It is not known, however, whether the EMPA-related BP lowering effect is preserved in patients under background antihypertensive treatment. We investigated the effect of 12 weeks with EMPA on 24 hour (h) mean BP in 823 T2D patients (age 60.2 ± 9.0 years, HbA1c 7.9 ± 0.7%, office systolic (S)/diastolic (D) BP 142.1 ± 12.3/83.9 ± 7.0 mmHg, mean ± SD) in a study with a randomized design. EMPA was given at 10mg (n=276) or 25mg (n=276) daily; 271 patients were randomized to placebo. Patients were under no, 1 or ≥ 2 antihypertensive drugs (n= 62, 353 and 408, respectively) such as an ACE inhibitor (ACEI), an angiotensin receptor antagonist (ARB) or a diuretic (D). HbA1c and weight were significantly reduced with EMPA 10 mg (mean [SE] -0.62% [0.05], -1.5 kg [0.2]) and EMPA 25 mg (-0.65 [0.05], -2.0 [0.2]) relative to placebo (all p &lt; 0.001). As shown in the Table, compared to placebo, EMPA at the lower or higher dose reduced 24h mean SBP and DBP in all groups. With the lower dose the BP reduction was somewhat less pronounced in patients with ≥ 2 antihypertensive drugs whereas with the higher dose the BP effect was similar irrespective of the presence and intensity of background antihypertensive treatment. The antihypertensive effect of EMPA was preserved also irrespective of the type of treatment (D and ACEIs or ARBs), especially at the higher dose. Thus, EMPA reduces BP in patients with T2D regardless of whether they are untreated or more or less intensively treated for hypertension.
Toughen Up, America!
Authors: Victor G. Heiser
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Klassifikation der Schizomyceten (Bakterien) Versuch einer wissenschaftlichen Klassifikation der Bakterien auf botanischer Grundlage.
Authors: Ernst. Pribram
Journal: Annals of Internal Medicine (1934)

The appearance of this work emphasizes the fact that a suitable and more or less satisfactory classification of bacteria is still lacking. Pribram attempts to classify bacteria on a scientific basis, as in botany. He also attempts to apply the nomenclature of an international codex of botanic nomenclature, with the view to its practical application. This new classification and nomenclature, he hopes, will facilitate the study of bacteria and will also prove to be more practical than the system now in use. Study of the work shows what labor and time he has expended; this can be appreciated only by a scholar who has the time and interest to read the book. With due respect to Pribram's wide experience and knowledge, which in themselves guarantee the value of the work, there are certain points that may invite some criticism, which he has foreseen. In the attempt to simplify the classification
Abstract 1550: Non-Doppler Two-Dimensional Strain Imaging for Early Detection of Heart Transplant Recipients with Coronary Stenoses
Authors: Michael Dandel, Hans Lehmkuhl, Christoph Knosalla, Roland Hetzer
Journal: Circulation (2007)

Background: Non-Doppler based two-dimensional (2D) strain imaging can reveal wall motion alterations not visible by conventional echocardiography (ECHO) and like tissue Doppler imaging (TDI) it can detect myocardial deformation (regional shortening and thickening) in the absence of visible ventricular wall displacement. Because TDI is dependent on the direction of Doppler angle of incidence in relation to myocardial motion, in our attempt to assess of the diagnostic value of strain and strain rate changes for early detection of transplant coronary arteriopathy (TCA), we focused our attention on the angle independent 2D strain imaging. Methods: In 68 heart recipients with normal LV wall motion and ejection fraction in conventional ECHO, 2D strain LV wall motion analysis were additionally performed before each follow-up cardiac catheterization. Circumferential, radial and longitudinal strain and strain rate were calculated from parasternal short axes and apical (3- and 4-chamber) views, respectively. 2D strain parameters were tested for relationships with angiographic findings. Results: In comparison with patients without TCA, those with angiographic TCA showed lower global systolic strain rate (radial, circumferential and longitudinal) values and longer systolic times measured from onset of contraction to the peak of systolic strain (p&lt;0.01). For radial peak systolic global strain rate values below 1.1/s we found a 93.3% likelihood of angiographic TCA in general, regardless of the presence or absence of focal stenoses on main coronaries. Regional strain and strain rate analyses showed differences in contraction asynchrony and dyssynergy indexes between patients with and without focal stenoses (p&lt;0.01). For longitudinal midsystolic dyssynchrony index values &gt;0.5 we found an 88.2% likelihood of relevant focal coronary stenoses (&gt;50% narrowing). Conclusions: In heart allografts with apparently normal LV kinetics in conventional ECHO, simple global strain rate measurements allow early TCA prediction, but without the ability to differentiate between diffuse TCA and predominantly focal coronary stenoses. Such differentiation is possible with more complex regional strain analyses using contraction asynchrony and dyssynergy indexes.
Military Ophthalmic Surgery.
Authors: Allen Greenwood
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Dentist's Own Book. A Faithful Account of the Experiences Gained During Forty-Six Years of Dental Practice, Including a Complete Bookkeeping and Recording System and a Description of the Management of a Dental Practice.
Authors: C. Edmund Kells
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survey of white coat hypertension
Authors: K. Kario, T. G Pickering, H. W Hense, M. Muschol, H. Schunkert
Journal: BMJ (1999)

Editor—Muscholl et al reported that patients with white coat hypertension showed evidence of target organ damage as manifested by changes in left ventricular structure and function when compared with normotensive subjects.1 Though interesting, their results are misleading.

The conventional method for identifying patients with white coat hypertension is by comparing blood pressure measured by a physician in a clinic with measurements made with 24 hour ambulatory monitors. Although there is no agreement as to the exact criteria, the central concept of white coat hypertension is that it is characterised by high blood pressure only in the medical setting; blood pressure is normal at other times. In Muscholl et al’s study, all the blood pressure measurements were made in a medical setting. After at least 30 minutes’ rest, blood pressure was measured three times by a technician, and the means of the second and third readings were used as the baseline or “non-physician” blood pressure. These readings were compared with blood pressure measured once by a physician after an echocardiographic examination. Patients were classified as having white coat hypertension when the blood pressure measured by the technician was <140/90 mm Hg and that recorded by the physician was ⩾160/95 mm Hg. The authors provide no evidence that the technicians’ readings are in any way representative of measurements in a non-medical setting, and previous work has shown that although blood pressure measured in a clinic by a non-physician (in this case a nurse) was substantially lower than the physician’s readings,3 it is not a reliable way of diagnosing white coat hypertension.

The difference in the procedures used by the technician and the physician is also a problem. The technician measured blood pressure three times before the echocardiographic examination, with the first reading omitted from the analysis, whereas the physician measured it only once, after the echocardiographic examination. This makes meaningful comparison between the two sets of readings difficult.

We do not accept the authors’ conclusion, based on their data, that white coat hypertension is not a benign condition, because their method of defining white coat hypertension is so different from other definitions in the medical literature.
Epidermal growth factor receptor overexpression in resected pancreatic cancer.
Authors: A. Mahipal, M. J. McDonald, A. Witkiewicz, B. I. Carr
Journal: Journal of Clinical Oncology (2011)

317 Background: The effect of overexpression of epidermal growth factor receptor (EGFR) in pancreatic carcinoma is uncertain. In this study, we examine the association between EGFR overexpression (membrane and cytoplasmic) and histopathologic features and clinical outcomes in patients post resection. Methods: Seventy three patients underwent curative resection for pancreatic cancer from 4/08 to 4/10. Tumor EGFR expression was determined immunohistochemically using EGFR pharmDxTM kit. Cytoplasmic overexpression was considered positive if EGFR expression was seen in the cytoplasm in ≥10% of cells. Cell membrane staining scores were assigned: 0 (no membrane staining), 1+ (incomplete membrane staining in ≥ 10% of cells, 2+ (complete weak/moderate membrane staining in ≥ 10% of cells) and 3+ (complete heavy staining in ≥ 10% of cells). A score of 2+ and 3+ were considered as membrane overexpression. Comparisons between EGFR overexpression and clinicopathologic features were assessed by chi-square test with p-value &lt; 0.05 as statistically significant. Proportional hazard regression was used to estimate progression free survival and overall survival. Results: Out of 73 patients, 43 (59%) and 50 (68%) patients had membrane and cytoplasmic EGFR overexpression respectively. AJCC stages were: stage I: 8, stage II: 63, stage III: 1 and stage IV: 1 patient. There was statistically significant correlation between cell membrane EGFR overexpression and lymph node positivity (p=0.04). Membrane EGFR overexpression was not significantly associated with local invasion, margin positivity, vascular invasion, perineural invasion, histologic grade or stage. Cytoplasmic EFGR overexpression was significantly associated with margin positivity (p=0.01) only. The hazard ratios (95% CI) for PFS and OS in patients with membrane EGFR overexpression was 1.37 (0.72-2.60) and 1.27 (0.62-2.61) respectively. The corresponding values for patients with cytoplasmic overexpression were 1.65 (0.80-3.37) and 1.25 (0.58-2.71) respectively. Conclusions: Membrane EGFR overexpression was associated with lymph node status and cytoplasmic EFGR overexpression with margin positivity. There was no association of EFGR expression and clinical outcomes. No significant financial relationships to disclose.
Abstract 10899: Direct Cath Lab Access Reduced Reperfusion Delays and Mortality for Transferred-in STEMI Patients: Insights From Mission: Lifeline
Authors: Lindsay L Anderson, William French, Andrew Peng, Amit Vora, Timothy Henry, Matthew Roe, Michael Kontos, Christopher Granger, Eric Bates, Tracy Wang
Journal: Circulation (2013)

Background: For STEMI patients requiring transfer for primary PCI, direct transfer to the STEMI receiving hospital cath lab may expedite reperfusion but can be logistically challenging. The differe...
Peptide Drug Delivery to the Brain
Authors: William M. Pardridge
Journal: Annals of Internal Medicine (1992)

Biological diversity of peptides peptides as potential neuropharmaceuticals in disorders of the brain overview of blood-brain barrier transport biology and experimental methodologies transnasal and intraventricular delivery of drugs peptide lipidization and liposomes bulk flow and receptor-mediated transcytosis of peptides through the blood-brain barrier absorptive-mediated transcytosis of peptides through the blood-brain barrier antibody delivery through the blood-brain barrier chimeric peptide pharmaceutical delivery through the blood-brain barrier development of brain-specific transport vectors - a molecular biological perspective.
Correcting Speech Defects and Foreign Accent.
Authors: Grace A. McCullough, Agnes V. Birmingham
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2994: Atherosclerotic Plaque Histology Predicts Restenosis after Carotid Endarterectomy: a Prospective Cohort Study in 500 Patients.
Authors: Willem E Hellings, Frans L Moll, Jean-Paul P De Vries, Dominique De Kleijn, Gerard Pasterkamp
Journal: Circulation (2007)

Introduction: Many studies have addressed clinical and angiographic risk factors for restenosis development after vascular interventions, but the composition of the atherosclerotic plaque at the intervention site has not been studied as a determinant of luminal re-narrowing after intervention. The aim of this study was to investigate the association between atherosclerotic plaque histology at baseline and restenosis development after carotid endarterectomy. Methods: Patients undergoing carotid endarterectomy were included in a longitudinal vascular biobank study. After surgical excision, the plaques were subjected to histological examination. The patients were prospectively followed-up with duplex ultrasound to assess restenosis (cut-off points: &gt;50% and &gt;70% renarrowing) one year after the intervention. The risk of restenosis was related to predefined plaque histological characteristics (macrophage and smooth muscle cell infiltration, collagen, calcifications, intra-plaque bleeding, luminal thrombus and lipid core size) adjusted for clinical characteristics (multivariable logistic regression analysis). Measurements of vessel diameter and intima-media thickness were performed using B-mode ultrasound in a subgroup of patients to discriminate between the roles of geometric vascular remodeling and neointima formation during follow-up. Results: In 500 consecutive patients (April 2002 – April 2007), plaque macrophage infiltration and a large lipid core were strongly associated with decreased risk of &gt;50% restenosis (adjusted odds ratio = 0.43 [0.26 – 0.70]; 0.38 [0.19 – 0.70]) and &gt;70% restenosis during follow-up (adjusted odds ratio = 0.36 [0.18 – 0.74]; 0.42 [0.17–1.03]), independent of clinical characteristics. The other histological characteristics were not related with restenosis. Duplex measurements (n=50) showed that vessels holding macrophage rich plaques revealed increased expansive geometric vascular remodeling during 1 year follow-up (+1.19 mm [0.03 – 2.36]). Conclusions: The absence of plaque macrophages and lipid core are powerful independent predictors of restenosis development after carotid endarterectomy. Plaque composition is linked with restenosis via geometric vascular remodeling.
Long-Term Outcomes of Treatment of Neovascular Age-Related Macular Degeneration
Authors: Mark C. Gillies, Anna Campain, Daniel Barthelmes, Judy M. Simpson, Jennifer J. Arnold, Robyn H. Guymer, Ian L. McAllister, Rohan W. Essex, Nigel Morlet, Alex P. Hunyor
Journal: Ophthalmology (2015)
Abstract 1835: Magnetic Resonance Imaging Detects Chronic Left Atrial Wall Injury Post Ablation of Atrial Fibrillation
Authors: Christopher J McGann, Eugene Khoumovski, Robert Oakes, Edward DiBella, Robert MacLeod, Dennis Parker, Brenda Fish, Marcos Daccarett, Nathan Segerson, Nassir F Marrouche
Journal: Circulation (2007)

Radiofrequency (RF) based ablation of atrial fibrillation (AF) through pulmonary vein antrum isolation (PVAI) is a promising treatment for this arrhythmia. Success of the procedure relies in part on the transmural extent of the RF lesions delivered to the left atrium (LA). We describe a novel technique using a 3D MRI to assess sites and extent of LA injury resulting from RF lesions after PVAI. Twelve patients (7 men, mean age 56±11 years) undergoing PVAI for AF were imaged pre and three months post procedure to detect LA scarring with delayed contrast-enhanced MRI using a 3D inversion recovery, navigated, gradient echo pulse sequence. LA injury post procedure was seen in all patients on MRI as areas of bright, signal enhancement, which correlated with the RF energy delivery map during PVAI (figure 1 ). Conclusion: This is the first study to show LA wall injury post PVAI using 3D MRI. These findings may prove important for tracking and monitoring outcomes of AF ablation. Figure 1. Posterior views of the left atrial wall in a patient one day pre (left) and three months post (right) ablation by delayed contrast-enhanced, navigated, 3D MRI. Regions of bright signal show injury resulting from RF ablation.