AB0116 ASSOCIATION BETWEEN GOUT CHARACTERISTICS AND DISEASE-SPECIFIC HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH GOUT
Authors: M. Stanislavchuk, I. Orlova, N. Shkolina, I. Vovk, I. Shapoval
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Gout is the most common inflammatory arthritis worldwide and is associated with reduced health-related quality of life (HRQoL) [1]. That is why defining and assessing factors that can affect the HRQoL is quite essential. <h3>Objectives:</h3> This study aimed to investigate the quality of life of gout patients and evaluate factors associated with poorer HRQoL. <h3>Methods:</h3> 151 patients were included in the analysis; the mean age of gout patients was (mean±SD) 52.4±9.2 years, and 100% were men. Diagnosis of gout is based on the ACR/EULAR 2015 criteria. Tophi were present in 51 (33.7%), the mean duration of gout was 8,0±5,4 years, the number of attacks in the past year was 3,8±2,7, and the number of involved joints was 8,0±5,4. The mean uric acid in serum (sUA) was 477.2 ± 120.5 µmol/l. Disease-specific HRQoL was evaluated using a translated and validated Ukrainian version of the Gout Impact Scale (GIS; scale 0-100) [2,3]. Statistical analysis was performed using MS Excel and SPSS22 software (©SPSS Inc.). <h3>Results:</h3> The mean score of the GIS total was 51,1±27,5. GIS scale scores showed that patients were significantly concerned about their gout overall ("gout concern overall", (GCO) 60,4±28,2) but judged their treatment was adequate as indicated by the "unmet gout treatment need" (UGTN) 40,2±19,6. The other three GIS scales ("gout medication side effects" (CMSE), "gout concern during attack" (GCDA) and "well-being during attack" (WBDA) mean scores were 44,3±31,1, 54,1±27,5 and 56,0±22,2, respectively. The correlation analysis proved that the total GIS had moderate statistically significant correlations with duration of the disease (r=0,42; p&lt;0,01), the number of affected joints (r=0,32; p&lt;0,01), the number of attacks (r=0,36; p&lt;0,01), the level of sUA r= (0,27; p&lt;0,01). <h3>Conclusion:</h3> Patients with gout are characterized by a significant decrease in their quality of life, which is demonstrated by the results of the GIS assessment. At the same time, patients' quality of life largely depended on the number of affected joints, the duration of the disease, the number of flares during the past year and the level of sUA. <h3>REFERENCES:</h3> [1] Watson L, Belcher J, Nicholls E, Chandratre P, Blagojevic-Bucknall M, Hider S, Lawton SA, Mallen CD, Muller S, Rome K, Roddy E. Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care. Rheumatology (Oxford). 2023 Aug 1;62(8):2748-2756. doi: 10.1093/rheumatology/keac706. [2] Hirsch JD, Lee SJ, Terkeltaub R, Khanna D, Singh J, Sarkin A, Harvey J, Kavanaugh A. Evaluation of an instrument assessing influence of Gout on health-related quality of life. J Rheumatol. 2008 Dec;35(12):2406-14. doi: 10.3899/jrheum.080506. [3] Orlova IV, Stanislavchuk MA, Gunko IP. Cross-cultural adaptation and validation of the Ukrainian version of the Gout Impact Scale. Ukrainian Journal of Rheumatology. 2017. №70 (4):42-46. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>