Observations on Addisin in Diseases of the Blood
Authors: Roger S. Morris, Murray L. Rich, Leon Schiff, John H. Foulger, Henry Felson
Journal: Annals of Internal Medicine (1933)

Article1 June 1933Observations on Addisin in Diseases of the BloodROGER S. MORRIS, F.A.C.P., MURRAY L. RICH, LEON SCHIFF, JOHN H. FOULGER, HENRY FELSONROGER S. MORRIS, F.A.C.P.Search for more papers by this author, MURRAY L. RICHSearch for more papers by this author, LEON SCHIFFSearch for more papers by this author, JOHN H. FOULGERSearch for more papers by this author, HENRY FELSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-12-1535 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been demonstrated1,2that the normal stomach in man, swine, dogs and cattle secretes an hemopoietic substance which, when properly concentrated and purified, may be injected intramuscularly into man. This substance is thermolabile, dialyzable through collodion, and exhaustible, and may be converted to an ethyl ester and extracted with non-aqueous solvents (ether, acetone, chloroform) without impairing its hemopoietic activity. These properties, which characterize both the material obtained from human gastric juice and that from the gastric contents of swine, practically exclude the possibility of its being an enzyme. It is probable that it is a physiological hemopoietic hormone, for...References1 MORRISSCHIFFBURGERSHERMAN RSLGJE: Specific hematopoietic hormone in normal gastric juice; preliminary note, Jr. Am. Med. Assoc., 1932, xcviii, 1080-1081.—The hematopoietic response in pernicious anemia following the intramuscular injection of gastric juice, Am. Jr. Med. Sci., 1932, clxxxiv, 778-782. CrossrefGoogle Scholar2 MORRISSCHIFFFOULGERRICHSHERMAN RSLJHMLJE: Observations on the hematopoietic hormone (addisin) in pernicious anemia, Brit. Med. Jr., 1932, ii, 1050-1051.—Über die hämatopoetische Wirkung konzentrierten Magensaftes (Addisin) bei perniziöser Anämie, Münch. med. Wchnschr., 1932, lxxix, 2074-2075.—Treatment of pernicious anemia; effect of a single injection of concentrated gastric juice (addisin), Jr. Am. Med. Assoc., 1933, c, 171-173. CrossrefGoogle Scholar3 CASTLEHEATHSTRAUSS WBCWMB: Observations on etiologic relationship of achylia gastrica to pernicious anemia; biologic assay of gastric secretion of patients with pernicious anemia having free hydrochloric acid and that of patients without anemia or with hypochromic anemia having no free hydrochloric acid, and of the rôle of intestinal impermeability to hematopoietic substances in pernicious anemia, Am. Jr. Med. Sci., 1931, clxxxii, 741-764. CrossrefGoogle Scholar4 WILKINSONKLEIN JFL: Active principle in hog's stomach effective in pernicious anemia, Lancet, 1932, i, 719-721. CrossrefGoogle Scholar5 WILLIAMSVANDER VEER HAJB: Demonstration of anti-anemic factor in bovine gastric juice, Proc. Soc. Exper. Biol. and Med., 1932, xxix, 858-859. CrossrefGoogle Scholar6 WILKINSON JF: Discussion on the value of liver in treatment, Proc. Roy. Soc. Med., 1931, xxiv (part 2), 948-951. Google Scholar7 CONNER HM: Increase of reticulated erythrocytes in pernicious anemia following intramuscular injection of gastric juice, Proc. Staff Meet., Mayo Clinic, 1932, vii, 213-216. Google Scholar8 MORRISSCHIFFFOULGER RSLM: Erythremia (polycythemia vera)—theory regarding etiology, Jr. Med., 1932, xiii, 318-319. Google Scholar9 FOULGERBURGERMORRISSCHIFF JHGNRSL: Preliminary studies of methods of concentration of the hemopoietic substance in gastric juice, Jr. Med., 1933, xiv, 90. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cincinnati, Ohio*Read before the Montreal Meeting of the American College of Physicians, February 7, 1933.†From the Department of Internal Medicine, University of Cincinnati, and the Medical Clinic, Cincinnati General Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExperimental studies on production of pernicious anemia by operation on the digestive tract1Basophil leucocytes and myelocytes after local injection of ventriculinLebertherapie bei GranulocytopenieThe relation of gastrectomy to anemiaPhysiologie und Pathologie des Antiperniciosaprinzips 1 June 1933Volume 6, Issue 12Page: 1535-1545KeywordsAcetonesEnzymesHormonesHospital medicineStomachSwine Issue Published: 1 June 1933 PDF downloadLoading ...