tbuckley/cabot-search huggingface dataset:
Abstract 8528: Functional Outcome 5 Years After Massive Pulmonary Embolism Treated with Percutaneous Mechanical Thrombectomy or Pharmacologic Therapy
Authors: Francesco Pelliccia, Giulio Speciale, Vincenzo Pasceri, Christian Pristipino, Adriana Roncella, Diego Irini, Alessio Arrivi, Gaetano Tanzilli, Enrico Mangieri, Giuseppe Mercuro, Carlo Gaudio
Journal: Circulation (2011)

Introduction. Percutaneous mechanical thrombectomy (PMT) has emerged as an effective treatment in patients with massive pumonary embolism (PE). The long-term functional outcome, i.e. development of chronic thromboembolic pulmonary hypertension (CTEPH), after PMT as compared to conventional therapy is unknown. Hypothesis. Are follow-up data on 5-year outcome different among survivors of massive PE treated either with PMT or drug therapy only? Methods. We studied 85 survivors of massive PE (defined as mean pulmonary arterial pressure (PAP)&gt;25 mm Hg and Miller index&gt;20/34) from 3 tertiary centers between January 2004 and December 2007. At referral, 52 patients (49±18 years) had thrombolitics and/or heparin (Gr.A), whereas 33 patients (43±13 years) underwent PMT (Angiojet, Possis Medical, Minneapolis, MN) because of relative or absolute contraindications to thrombolytics and/or heparin (Gr.B). All patients were evaluated at 6-month intervals over a 5-year follow-up period after discharge. Results. While in-hospital, Gr.A showed significant improvement in functional class (from 3.6±1.2 to 2.3±1.1, p&lt;0.001) and increase in oxygen saturation (from 77±21 to 94±19%, p&lt;0.001). In Gr.B, PMT resulted in immediate angiographic improvement in 22/23 patients, with a rapid amelioration in functional class (from 3.3±0.9 to 2.1±0.7, p&lt;0.001) and an increase in oxygen saturation (from 71±15 to 92±17%, p&lt;0.001). At discharge, peak systolic PAP resulted significantly (p&lt;0.001) decreased in both Gr.A (from 57±28 to 35±22 mm Hg) and Gr.B (from 65±31 to 31±19 mm Hg). The clinical improvement was maintained during the follow-up in both groups, and after 5 years a peak systolic PAP&gt;50 mm Hg was recorded in 6/52 Gr.A patients and 2/33 Gr.B patients (12 vs. 6%). Conclusions. PMT is an effective alternative to pharmacologic treatment for PE, and is associated with a lower tendency to develop CTEPH over 5 years.
Abstract 5664: Circulating Soluble Endoglin is a Sensitive Predictor of Pulmonary Arterial Hypertension and Exercise Function
Authors: Paul B Yu, Roham T Zamanian, Rajeev Malhotra, Jonathan Schmidt, Donna Y Deng, Carol S Lai, William Parker, Kenneth D Bloch, C. Gregory Elliott
Journal: Circulation (2009)

Rationale : Circulating biomarkers of inflammation and endothelial dysfunction are sensitive for the presence of systemic vascular disease and may aid in the early assessment of pulmonary arterial hypertension (PAH). Current biomarkers for PAH such as NT-proBNP provide useful prognostic data but detect ventricular strain associated with advanced or severe disease. Objectives : We tested the hypothesis that circulating protein markers of endothelial dysfunction or inflammation – soluble endoglin (sEng), osteoprotegerin (OPG), high-sensitivity C-reactive protein (hsCRP) and interleukin 15 (IL-15) – may predict the presence or severity of PAH. Methods : Circulating protein levels were measured by immunoassay in a total of 84 individuals: 42 with WHO diagnostic group 1 PAH of various etiologies (see table ), 11 of their first-degree relatives, and 31 healthy age- and gender-matched controls. Measurements and Main Results: Circulating levels of sEng, hsCRP, OPG, and NT-proBNP were significantly elevated in PAH patients versus controls, whereas IL-15 levels were elevated only in PAH associated with connective tissue disease (p&lt;0.001). sEng was superior to NT-proBNP for predicting PAH by receiver operating characteristic analysis (p=0.015). A sEng threshold of 3.7 ng/ml had a sensitivity of 86% and specificity of 74% for the presence of PAH, compared to a sensitivity of 70% and specificity of 74% for an NT-proBNP threshold of 180 pg/ml. Moreover, sEng levels correlated inversely with six minute walk distances (r=−0.48, p&lt;0.05). Conclusions : Serum markers of inflammation or vascular dysfunction are sensitive predictors for the presence of PAH of all etiologies and in the case of sEng correlate with reduced exercise capacity. Levels of IL-15 are elevated in PAH associated with connective tissue disease. Markers of inflammation may be more sensitive for PAH than those of ventricular strain and may provide unique noninvasive data. Biomarker levels in controls, PAH patients, and 1st degree relatives
Abstract 1982: Interference with Implantable Electrical Active Devices by Wireless Communication Networks (WLAN) in Europe and USA
Authors: Fritz Mellert, Christian Schneider, Osman Balta, Claus J Preusse, Georg Nickenig, Armin Welz
Journal: Circulation (2006)

OBJECTIVE: With a rapid spread of wireless local area networks (WLAN) in offices, hospitals and home areas, the question arises whether this radio based technology might compromise pacemakers (PM) and implantable cardioverter defibrillators (ICD). Particularly with regard to US legal requirements (FCC) that enable higher transmitting power than european regulations (ETS), interference of conventional WLAN with PM and ICD has to be investigated. METHODS: In this experimental in-vitro study, we tested 25 PM and 22 ICD-models of several manufacturers with two WLAN-configurations (maximum transmitting power ETS 100 mW and FCC 1000 mW) to assess the potential for interference. WLAN-setups were tested with different distances of the antenna to the device and with several transmitting modes. Interference was rated according to type and significance in 3 classes. RESULTS: The incidence of any type of interference was 10.6 %. There was no clinical significant class 1 or 2 interference (inhibition, reprogramming, s...
Abstract 14889: Inducible Myocardial Ischemia and Outcomes in Patients with Coronary Artery Disease and Left Ventricular Dysfunction Treated with Medical Therapy or Surgical Revascularization. A Report from the STICH Trial
Authors: Julio A Panza, Thomas A Holly, Federico M Asch, Lilin She, Patricia A Pellikka, Eric J Velazquez, Kerry L Lee, Salvador Borges-Neto, Pedro S Farsky, Robert H Jones, Daniel S Berman, Robert O Bonow
Journal: Circulation (2012)

Background: The clinical significance of stress-induced ischemia in patients with coronary artery disease (CAD) and moderately to severely reduced left ventricular (LV) ejection fraction (EF) is la...
FURTHER OBSERVATIONS ON THE USE OF LIBERALIZED DIETS IN THE TREATMENT OF DIABETES
Authors: H J JOHN
Journal: Annals of Internal Medicine (1951)

Article1 December 1951FURTHER OBSERVATIONS ON THE USE OF LIBERALIZED DIETS IN THE TREATMENT OF DIABETESHENRY J. JOHN, M.D., F.A.C.P.HENRY J. JOHN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-6-1318 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe treatment of diabetes can be made either a very difficult and disheartening problem to the patient, or a relatively easy one. It can be made an expensive problem, or relatively inexpensive. It can cause the patient considerable loss of time from his work, or very little, or none. All these are important factors, to be considered by the patient and the physician alike.WHAT IS THE MEDICAL PROBLEM INVOLVED?The medical problem involved in the control of diabetes is the control of abnormal hyperglycemia, for thereby the diabetes is controlled. When we have succeeded in the control of abnormal...Bibliography1. John HJ: Control of diabetes: glycosuria an unreliable index to glycemia, Ohio State M. J. 46: 1073-1076, 1950. MedlineGoogle Scholar2. John HJ: A liberal regimen of treatment of diabetes, Am. J. Med. 5: 537-547, 1948. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland Ohio*Presented at the Thirty-second Annual Session of the American College of Physicians, St. Louis, Mo., April 11, 1951. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCurrent Concepts in Diabetes MellitusCompatible hyperglycemia 1 December 1951Volume 35, Issue 6Page: 1318-1328KeywordsDietHyperglycemia ePublished: 1 December 2008 Issue Published: 1 December 1951 PDF downloadLoading ...
CC-486 (Oral Azacitidine) Following Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) in Patients with Myelodysplastic Syndromes (MDS) or Acute Myeloid Leukemia (AML)
Authors: Basem M. William, Marcos de Lima, Betul Oran, Richard Champlin, Esperanza B Papadopoulos, Sergio Giralt, Bart L. Scott, Joel Hetzer, Xiwei Wang, Eric Laille, Barry S. Skikne, Charles Craddock
Journal: Blood (2014)
Abstract 13228: Apoptosis Occurs in Late Stages of Unloading Related Ventricular Remodeling
Authors: Henriette Brinks, Celine Giroud, Florian S Schoenhoff, Thierry P Carrel, Walter J Koch, Hendrik T Tevaearai, Marie-Noelle Giraud
Journal: Circulation (2011)

Objective: As previously shown, myocardial unloading of a normal heart results in progressive atrophy associated with gradual loss of cardiomyocyte volume, shifted myocyte/connective tissue ratio, ...
Abstract 15018: Inverse Frequency Dependence of the Chemoreflex - is the Gain Measured with Rebreathing Relevant to Periodic Breathing in Heart Failure?
Authors: Charlotte Manisty, Alberto Giannoni, Yoseph Mebrate, Jamil Mayet, Keith Willson, Darrel P Francis
Journal: Circulation (2011)

Background High chemoreflex gain in heart failure may result in periodic breathing (oscillations in cardiorespiratory parameters with a period of about a minute). Clinical research generally separa...
P0022 : Whole organ engineering using decellularized scaffold for liver transplantation in large animal model
Authors: K. Inomata, H. Yagi, K. Tazima, K. Sugiyama, M. Hieda, Y. Abe, T. Hibi, M. Kitago, M. Shinoda, T. Akaike, O. Itano, Y. Kitagawa
Journal: Journal of Hepatology (2015)
Abstract 9642: Prolongation of AERP and APD with the Selective IKur inhibitor, BMS-394136, is Increased in the Zucker Diabetic Fatty Rat
Authors: Dezhi Xing, Jialong Zhu, James K Hennan, Paul C Levesque
Journal: Circulation (2012)

Introduction: Diabeties mellitus is a risk factor for atrial fibrillation (AF). We previously reported that atrial ischemia increases activity of a selective IKur inhibitor, BMS-394136, on atrial effective refractory period (AERP) and action potential duration (APD) without effecting ventricular effective refractory period (VERP) in dog heart. This study evaluated the efficacy of BMS-394136 on AERP and APD in Zucker Diabetic Fatty (ZDF) rats. Methods: Male ZDF370 (obese and diabetic) and ZDF371 (lean control) rats on normal diet, averaging 7 months of age, were entered into the study. After induction of anesthesia, a 2F multielectrode was placed into right ventricle to measure VERP. BMS-394136 (10 mg/kg) was infused over 5 min through the jugular vein. After VERP assessment, hearts were removed and perfused in a Langendorff apparatus with Tyrode’s buffer for assessment of AERP and APD at BMS-394136 concentrations of 1.0, 3.0 and 10.0 µM, respectively. After Langendorff perfusion, atrial strips were removed and studied with standard microelectrode techniques in perfusion. Results: (*p&lt;0.05). The average weight and blood glucose was 367g and &gt;600mg/dl in the ZDF370 rats and 465g* and 253* mg/dl in the ZDF371 rats. VERP was prolonged by BMS-394136 in vivo by 21±1.7 ms (39%) in ZDF370 rats (n=10), and by 24±1.7 ms (50%) in ZDF371 rats. No differences in APD100 (64±4ms vs 64±3 ms) or AERP (29±2ms vs 25±2ms) were observed at baseline in Langendorff mode from ZDF370 and ZDF371 hearts (n=4/each). However, BMS-394136 dose-dependently prolonged APD100 and AERP to a greater extent in ZDF370 rats at 1.0µM (11%* and 36%*), 3.0µM (27%* and 44%*) and 10.0µM (33%* and 64%*) than in ZDF371 rats at 1.0µM (-2%* and 3%), 3.0µM (3% and 3%) and 10.0 µM (8% and 14%). In atrial strips (n=4), BMS-394136 increased APD30 by (%) 0±2, 22±3, 33±2*, APD50 by(%) 14±4, 36±5, 32±7, 50±4* and APD90 by (%)3±4, 14±9, 23±5* at concentrations of 1.0µM, 3.0µM and 10.0 μ M in ZDF370 rats, no effect was observed on APD prolongation in ZDF371 rats. Conclusions: Diabeties mellitus may increase the efficacy of the selective IKur inhibitor, BMS-394136, on prolongation of AERP and APD. The absence of effect with BMS-394136 on VERP confirms the atrial selective activity of this compound or ion channel remodeling.
Impact on overall survival and disease-free survival of adjuvant chemotherapy after neoadjuvant chemoradiotherapy for rectal cancer.
Authors: Rafael amaral de Castro, Carlos Eduardo Paiva, Rogerio Saad-Hossne, Odair Carlito Michelin, Cristiano de padua Souza
Journal: Journal of Clinical Oncology (2012)

e14173 Background: Colorectal cancer is the second most common cancer with 2,4 million people diagnosed. The rectal cancer (RC) is 27% of these cases. Neoadjuvant chemoradiotherapy (NCRT) has become standard but brought controversy in the adjuvant treatment. The objective was to assess the impact of adjuvant chemotherapy after NCRT. Methods: Between mar/96 and Oct/2010, 84 patients received NCRT, and 58 patients underwent resection of the rectum. The NCRT consisted of 5-FU 350mg/m2, D1-D5 (50% of cases) or 5-FU 425mg/m2, D1-D3 (43%) with LV 20mg/m2 bolus in the 1st and 5th week of the 25 sessions of radiotherapy in linear accelerator (total 45 - 50 Gy). When performed, Adjuvant chemotherapy (ADJC) consisted of 5-FU 425mg/m2, LV 20mg/m2, both on D1-D5 for 4 cycles. Evaluation of Overall Survival (O.S) and Disease-Free Survival (DFS) performed using Kaplan-Meier curve in SPSS version 13.0 Results: Of the 58 patients who underwent surgery, 90% were stage II, 51% occurred in the lower rectum and 66% were ECOG 1. Pathologic Complete Response (PCR) was obtained in 25.8% (15) of patients (group 1). Of these, 20% (3) received ADJC. Patients without PCR (group 2) received ADJC in 51% of the cases (22). The mean follow-up was 41 months. Both the DFS (HR: 2.594, 95% CI: 1134-5938, p = 0.024) and OS (HR: 2.615, 95% CI: 1005-6807, p = 0.0488) were higher in patients with PCR independent of the use of ADJC. On the other hand, patient treated with ADJC vs without ADJC, independent of presence of PCR, did not alter DFS (p = 0.74) or OS (p = 0.32). In PCR patients, ADJC do not interfere in the outcome (DFS, p = 0.76; SG, p = 0.73). In group 2 (patients without PCR), the subgroup with ADJC, there was a trend towards better SLD (p = 0.06) and OS (p = 0.06). Those who did not receive ADJC in group 2 had worse SLD (p = 0.011) and OS (p = 0.028) compared with group-1. Conclusions: Adjuvant treatment after NCRT did not increase OS or DFS. Patients without PRC had worse results without ADJC, compared to those with PCR. The first, probably, the subgroup of patients who benefited most from the use of ADJC. PCR improves OS and DFS regardless of ADJC, being perhaps the group that does not deserve ADJC.
Abstract 15028: PTEN Inhibition Preserves Cardiomyocyte Contractility and Improves Murine Cardiac Arrest Survival
Authors: Jing Li, Zuohui Shao, Huashan Wang, Changqing Li, Benjamin Steinhorn, Qiang Zhong, Xiangdong Zhu, Jim Costakis, Gabrielle Bunney, David G. Beiser, Terry L. Vanden Hoek
Journal: Circulation (2012)

Introduction: Post-cardiac arrest myocardial stunning is often lethal in the first few hours after resuscitation. We previously reported this stunning is reversed by cooling via an Akt-dependent pr...
Sylvian fissure size in schizophrenia measured with the magnetic resonance imaging rating protocol of the Consortium to Establish a Registry for Alzheimer's Disease
Authors: Joseph M. Schwartz, Elizabeth Aylward, Patrick E. Barta, Larry E. Tune, Godfrey D. Pearlson
Journal: American Journal of Psychiatry (1992)

Since previous work indicated smaller than normal temporal lobe structures in schizophrenic patients, the authors tested the hypothesis that this abnormality might be reflected in abnormally large sylvian fissures.The subjects were 48 schizophrenic patients and 51 normal comparison subjects matched groupwise with regard to age and sex. CSF spaces (sylvian fissures, temporal lobe sulci, temporal horns, third ventricle, lateral ventricles, and superficial cerebral sulci) were visually assessed with the magnetic resonance imaging rating protocol of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD).The sylvian fissures of the schizophrenic patients were found to be bilaterally wider than those of the comparison subjects. There were no other significant differences.Schizophrenic patients appear to have larger than normal sylvian fissures, which may reflect smaller superior temporal gyri.
Abstract 2292: Doppler-Derived Mitral Regurgitation Volume as a Predictor of Postoperative Left Ventricular Dysfunction after Mitral Valve Repair in Patients with Preoperatively Normal Left Ventricular Function
Authors: Tetsuhiro Yamano, Nozomi Wada, Yoshiki Matusmura, Manatomo Toyono, Takahiro Shiota
Journal: Circulation (2008)

We anecdotally encounter postoperative left ventricular (LV) dysfunction after surgical correction for mitral regurgitation (MR), despite preoperative ejection fraction (EF) and end-systolic dimension (LVDs) meeting the current guidelines. We sought to clarify if Doppler-derived MR volume could be predictive of “unexpected” LV dysfunction after mitral valve (MV) repair. We retrospectively analyzed pre- and post-operative (median 4th postoperative day) echocardiograms of consecutive 161 patients (104 men, age 57±13 years) who underwent MV repair for pure and isolated MR, and had preoperatively normal LV function, defined as both EF >60% and LVDs  P 0.001], as well as LVDs and LV end-diastolic and left atrial dimension. However, preoperative EF was not significantly different between these 2 groups [67 (63 to 73) vs. 69 (65 to 74) %,  P =0.079]. Echocardiographic independent predictor of LV dysfunction was MR volume, as well as LVDs (TABLE). Using optimal cutoff value of 80 mL for MR volume combined with that of 35 mm for LVDs, we could predict postoperative LV dysfunction more accurately than using the value for only LVDs (correct classification rate of 0.87, 95% confidence interval 0.82 to 0.92 vs. those of 0.70, 0.63 to 0.77,  P 0.001). Doppler-derived MR volume could be a powerful predictor of unexpected postoperative LV dysfunction. Earlier indication of MV repair than the current guidelines may prevent postoperative LV dysfunction in patients with LVDs >35 mm and MR volume >80 mL.
Abstract 5585: Inhibition of Notch Signalling by Soluble Form of Delta-like 4 Converts Reparative Angiogenesis Into Inefficient Inflammatory-like Neovascularization in a Murine Model of Peripheral Ischemia
Authors: Ayman Al Haj Zen, Costanza Emanueli, Paolo Madeddu
Journal: Circulation (2009)

Notch signalling by the ligand Delta-like 4 (Dll4) was previously shown to be absolutely required for normal embryonic vascular development and is involved in tumour angiogenesis. In this study, we aimed to define the effect of inhibition of Dll4-mediated signalling in ischemia-induced angiogenesis. An adenovirus encoding soluble Dll4 (AdsDll4) or empty vector (control) was injected in murine ischemic limb muscles (n=15 per group). Analysis of AdsDll4 treated muscles by PCR showed that Notch downstream genes were downregulated compared to control. Five days following ischemia induction, whole-mount immunostaining technique was applied to visualize and analyze vessel architecture in 3D by confocal microscopy. In AdsDll4-treated ischemic muscle, neo-vessel network was considerably disrupted and contained more sprouting endothelial cells (Fig ). Interestingly, we observed a strong accumulation of infiltrating inflammatory CD45 positive cells in the AdsDll4-treated ischemic muscle compared to control (958±252 vs 378±131 cell/mm2, p&lt;0.0005). Blood flow recovery was impaired in AdsDll4 treated animals with compared to control measured by Laser Doppler Perfusion Imaging (perfusion ratio: 0.49±0.2 vs 0.74±0.1, p=0.02, 7 days after ischemia). Furthermore, the perfused vessels visualized by lectin infusion of live animals were markedly reduced in AdsDll4 treated group in comparison to control. In conclusion, our findings suggest that Notch/Dll4 signaling could play a crucial role in ischemia-induced angiogenesis not only by regulating vascular sprouting but also coordinating the cross-talk between infiltrating inflammatory cells and endothelial cells. Fig. In control Ischemic muscle (Ad-null) the infiltrating cells were aligned along with the long axis of the vessels whereas in AdsDll4-treated ischemic muscle they lost that relationship with vessels and were aggregated indiscriminately in clusters. In the AdsDll4-injected ischemic muscle, sprouting endothelial cells are increased in chaotic manner. CD45 (Pan-leukocyte marker, green), Isolectin B4 (Endothelial cell marker, red) - scale bar=50 μ m
The Biology and Etiology of Cancer
Authors: Leo Loeb
Journal: Annals of Internal Medicine (1931)

Article1 January 1931The Biology and Etiology of CancerLEO LOEBLEO LOEBSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-7-669 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe present era in cancer research dates back somewhat more than 30 years. In this paper I must limit myself to a rapid survey of the advances made during this period and to an indication of how I believe the isolated facts thus accumulated can be combined into a consistent theory of cancer.To state the essential fact, cancer cells are cells which were originally, either ordinary tissue or embryonal cells, and which, under the influence of environmental stimuli, acting in combination with hereditary factors, assume an increased intensity of proliferation; in some cases this proliferation is combined with increased... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LEO LOEB*(From the Department of Pathology, Washington University School of Medicine, St. Louis, Mo.).†Presented in the Symposium on Cancer before the American College of Physicians, Minneapolis, Feb. 13, 1930. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1931Volume 4, Issue 7 Page: 669-675 Keywords Cells Etiology ePublished: 1 December 2008 Issue Published: 1 January 1931 PDF downloadLoading ...