tbuckley/cabot-search huggingface dataset:
Sunitinib in Tandem With 177Lu-DOTATATE Therapy in Advanced Pancreatic Neuroendocrine Tumor
Authors: Piyush Aggarwal, Vinisha Gunasekaran, Ashwani Sood, Kushal Gupta, Chandan Krushna Das, Bhagwant Rai Mittal
Journal: Clinical Nuclear Medicine (2023)

Abstract Various systemic treatment options are available for advanced pancreatic neuroendocrine tumors (NETs); however, individual treatment may be suboptimally effective. Sunitinib inhibits multiple kinases and signaling pathways with delay in tumor growth, whereas peptide radioreceptor therapy (PRRT) delivers targeted radiation to the tumors in pancreatic NETs. There is a dearth of literature on the combined or tandem use of these systemic treatment modalities. We present a case of 40-year-old man with advanced pancreatic NET where PRRT or sunitinib as monotherapy had a suboptimal treatment response, but the use of sunitinib in tandem with 177 Lu-PRRT reinforced the response to the treatment.
Serial Migration of Iatrogenic Microembolus on 18F-FDG PET/CT Images
Authors: Yeon-Hee Han, Hwan-Jeong Jeong, Seok Tae Lim
Journal: Clinical Nuclear Medicine (2023)

Abstract A 51-year-old woman who had a history of partial nephrectomy underwent an 18 F-FDG PET/CT image for a routine health checkup. Focal intense FDG avidity without any anatomical correlation on CT was detected in the lung. On the delayed image after 20 minutes, the focal activity migrated to a more peripheral portion. An iatrogenic microembolus is a rare but crucial false-positive finding that nuclear physicians should be aware of. Our case emphasizes the importance of meticulous FDG injection and cautious interpretation. In addition, delayed PET/CT imaging through wet reading can aid in diagnosing and help prevent unnecessary investigations.
A Rare Case of Thyroid Sarcoidosis
Authors: Tina Nazerani-Zemann, Birgit Pernthaler, Luca Abete, Valerie Fanny Wienerroither, Christian Gstettner
Journal: Clinical Nuclear Medicine (2023)

Abstract Thyroid sarcoidosis is a rare manifestation of sarcoidosis, an inflammatory disease characterized by the formation of noncaseating granulomas in various organs. The diagnosis of thyroid sarcoidosis is challenging because of its nonspecific symptoms and the absence of specific biomarkers. Here, we report the case of a 43-year-old woman who presented with a 2-year history of neck swelling, dysphonia, and dysphagia, and suspected nodule in her left thyroid.
Author Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention
Authors: Makoto Araki, Seung-Jung Park, Harold L. Dauerman, Shiro Uemura, Jung-Sun Kim, Carlo Di Mario, Thomas W. Johnson, Giulio Guagliumi, Adnan Kastrati, Michael Joner, Niels Ramsing Holm, Fernando Alfonso, William Wijns, Tom Adriaenssens, Holger Nef, Gilles Rioufol, Nicolas Amabile, Geraud Souteyrand, Nicolas Meneveau, Edouard Gerbaud, Maksymilian P. Opolski, Nieves Gonzalo, Guillermo J. Tearney, Brett Bouma, Aaron D. Aguirre, Gary S. Mintz, Gregg W. Stone, Christos V. Bourantas, Lorenz Räber, Sebastiano Gili, Kyoichi Mizuno, Shigeki Kimura, Toshiro Shinke, Myeong-Ki Hong, Yangsoo Jang, Jin Man Cho, Bryan P. Yan, Italo Porto, Giampaolo Niccoli, Rocco A. Montone, Vikas Thondapu, Michail I. Papafaklis, Lampros K. Michalis, Harmony Reynolds, Jacqueline Saw, Peter Libby, Giora Weisz, Mario Iannaccone, Tommaso Gori, Konstantinos Toutouzas, Taishi Yonetsu, Yoshiyasu Minami, Masamichi Takano, O. Christopher Raffel, Osamu Kurihara, Tsunenari Soeda, Tomoyo Sugiyama, Hyung Oh Kim, Tetsumin Lee, Takumi Higuma, Akihiro Nakajima, Erika Yamamoto, Krzysztof L. Bryniarski, Luca Di Vito, Rocco Vergallo, Francesco Fracassi, Michele Russo, Lena M. Seegers, Iris McNulty, Sangjoon Park, Marc Feldman, Javier Escaned, Francesco Prati, Eloisa Arbustini, Fausto J. Pinto, Ron Waksman, Hector M. Garcia-Garcia, Akiko Maehara, Ziad Ali, Aloke V. Finn, Renu Virmani, Annapoorna S. Kini, Joost Daemen, Teruyoshi Kume, Kiyoshi Hibi, Atsushi Tanaka, Takashi Akasaka, Takashi Kubo, Satoshi Yasuda, Kevin Croce, Juan F. Granada, Amir Lerman, Abhiram Prasad, Evelyn Regar, Yoshihiko Saito, Mullasari Ajit Sankardas, Vijayakumar Subban, Neil J. Weissman, Yundai Chen, Bo Yu, Stephen J. Nicholls, Peter Barlis, Nick E. J. West, Armin Arbab-Zadeh, Jong Chul Ye, Jouke Dijkstra, Hang Lee, Jagat Narula, Filippo Crea, Sunao Nakamura, Tsunekazu Kakuta, James Fujimoto, Valentin Fuster, Ik-Kyung Jang
Journal: Nature Reviews Cardiology (2023)
Infant Feeding Practices and Metal Concentrations in Children’s Blood
Authors: Anna R. Smith, Ruwan Thilakaratne, Pi-I D. Lin, Sheryl L. Rifas-Shiman, Marie-France Hivert, Emily Oken, Andres Cardenas
Journal: JAMA Network Open (2023)

This cohort study assesses the association between 4 infant feeding practices and concentrations of 8 nonessential and 7 essential metals in red blood cells.
Life-Threatening Involvement of Bilateral Pulmonary Arteries in Behçet Disease on FDG PET
Authors: Naifeng Hou, Chengzhong Fan, Guohua Shen
Journal: Clinical Nuclear Medicine (2023)

Abstract A 29-year-old man with Behçet disease exhibiting lower-limb swelling and dyspnea underwent 18 F-FDG PET/CT. The imaging revealed bilateral pulmonary artery involvement, and pulmonary artery aneurysms and mural thrombus were confirmed by CT pulmonary angiography. This case underscores the utility of 18 F-FDG PET in identifying life-threatening vasculitis complications in Behçet disease.
Gastric Schwannoma Demonstrated on 18F FDG PET/CT With Pathological Correlation
Authors: Jeffrey Chen, Chuong Bui, Han Loh, Robert Mansberg
Journal: Clinical Nuclear Medicine (2023)

Abstract A 66-year-old man with background hypertension and type 2 diabetes presented with 1 month history of epigastric pain for investigation. Abdominal CT and MRI identified round homogeneously enhancing mass arising from the lesser curvature of the stomach. On 18 F-FDG PET/CT, the gastric mass demonstrated intense FDG uptake (SUV max , 9.6). The patient subsequently underwent partial gastrectomy, with pathological features and immunohistochemical patterns consistent with gastric schwannoma.
Workers at Risk of Silicosis—Ongoing Overexposure and Lack of Medical Surveillance—Reply
Authors: Jane C. Fazio, Sheiphali A. Gandhi, Robert J. Harrison
Journal: JAMA Internal Medicine (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Reported Variation in Hospital Billing Quality
Authors: Kranti C. Rumalla, Missy Danforth, Jean-Luc Tilly, Chen Dun, Christi M. Walsh, Martin A. Makary
Journal: JAMA (2023)

This study examines how US hospitals perform on billing quality measures, including legal actions taken by a hospital to collect medical debt, the timeliness of sending patients an itemized billing statement, and patient access to a qualified billing representative.
Preventing the Continuing Tragedy of Silicosis
Authors: Gregory R. Wagner, David Michaels
Journal: JAMA Internal Medicine (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Late Subacute Cerebral Hematoma Mimicking a Metastasis on PSMA PET/CT
Authors: Nuno Vaz, Eric Dietsche, Michael A. Mooney, Atish D. Choudhury, Heather A. Jacene
Journal: Clinical Nuclear Medicine (2023)

Abstract A 64-year-old man with history of prostate cancer was found to have rising prostate-specific antigen after radical prostatectomy. 18 F-DCFPyL PET/CT demonstrated a prostate-specific membrane antigen–avid brain lesion in the left frontal lobe and no other findings to account for rising prostate-specific antigen. Brain MRI demonstrated a small intraparenchymal hematoma with late subacute features in this location. The patient reported a seizure 3 weeks before but was otherwise asymptomatic, and neurologic examination was normal. Follow-up MRI demonstrated gradual decrease in size of the hematoma without treatment.
Hypothermia vs Normothermia in Patients With Cardiac Arrest and Nonshockable Rhythm
Authors: Fabio Silvio Taccone, Josef Dankiewicz, Alain Cariou, Gisela Lilja, Pierre Asfar, Jan Belohlavek, Thierry Boulain, Gwenhael Colin, Tobias Cronberg, Jean-Pierre Frat, Hans Friberg, Anders M. Grejs, Guillaume Grillet, Patrick Girardie, Matthias Haenggi, Jan Hovdenes, Janus Christian Jakobsen, Helena Levin, Hamid Merdji, Hassane Njimi, Paolo Pelosi, Christian Rylander, Manoj Saxena, Matt Thomas, Paul J. Young, Matt P. Wise, Niklas Nielsen, Jean-Baptiste Lascarrou
Journal: JAMA Neurology (2023)

International guidelines recommend body temperature control below 37.8 °C in unconscious patients with out-of-hospital cardiac arrest (OHCA); however, a target temperature of 33 °C might lead to better outcomes when the initial rhythm is nonshockable.
Trends in HPV Vaccination Before Age 13 Years in the US National Immunization Survey–Teen
Authors: Jodie L. White, M. Kate Grabowski, Thomas C. Quinn, Aaron A. R. Tobian, Eshan U. Patel
Journal: JAMA Pediatrics (2023)

This survey study uses data from the National Immunization Survey–Teen to examine human papillomavirus (HPV) vaccination rates in adolescents aged 13 to 17 years, including rates of series completion before age 13 years.
A 51-Year-Old Woman With Abnormal Corpus Callosum Signal
Authors: Nina Xie, Qiying Sun
Journal: JAMA Neurology (2023)

A 51-year-old woman presented with a 2-year history of progressive memory loss and left limb numbness. Imaging showed multifocal restricted diffusion in the corpus callosum and diffuse subcortical white matter hyperintensities and corpus callosum atrophy. What is your diagnosis?
Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers
Authors: Wagner S. Brum, Kieran F. Docherty, Nicholas J. Ashton, Henrik Zetterberg, Oskar Hansson, John J. V. McMurray, Kaj Blennow
Journal: JAMA Neurology (2023)

This exploratory analysis of a randomized clinical trial evaluates the effect of neprilysin inhibition on Alzheimer disease blood biomarkers in patients with heart disease.
Potential Selection Bias in Preterm Infant Mortality Study
Authors: Tormod Rogne, Bohao Wu, Nicola L. Hawley
Journal: JAMA Pediatrics (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Use of New Audio-Only Telemedicine Claim Modifiers
Authors: Anna M. Morenz, Jonathan Staloff, Joshua M. Liao, Edwin S. Wong
Journal: JAMA Network Open (2023)

Importance Policymakers at both the state and federal levels face decisions about coverage of audio-only telemedicine amid a dearth of reliable data due to changes and variation in billing practices. Objective To describe early trends in the use of new audio-only telemedicine claims modifiers 93 and FQ in Washington State, which were introduced to improve the designation and identification of audio-only telemedicine claims. Design, Setting, and Participants This retrospective cohort study analyzed claims data from the Washington All-Payer Claims Database from January to November 2022. Participants included 4.3 million children and adults insured for at least 6 months in 2021 through public or private insurance plans. Exposures Use of audio-only telemedicine was compared by age, race, ethnicity, insurance type, rurality, and Social Vulnerability Index. Main Outcomes and Measures Audio-only telemedicine services were identified by claims appended by Current Procedural Terminology ( CPT ) code modifiers 93 or FQ or that included telephone-only CPT codes. Modifiers 93 and FQ denote audio-only telemedicine services for any reason and for behavioral health concerns, respectively. Results In 2022, there were a total of 917 589 audio-only telemedicine services, of which 345 941 (38%) were appended with modifier FQ and 55 352 (6%) with modifier 93. Audio-only telemedicine services with these modifiers were most frequent for behavioral health diagnoses or routine prenatal and postpartum care. Individuals who used telemedicine exclusively via audio-only modality were more likely to be older (mean [SD] age, 46.0 [22.5] vs 42.0 [21.4] years) and insured by Medicare (41 758 of 196 225 [21%] vs 95 962 of 707 626 [14%]) than those who used at least 1 audiovisual service. Conclusions and Relevance In this cohort study of a statewide all-payer claims database, modifiers 93 and FQ offered the important capability to identify audio-only telemedicine services beyond telephone-only CPT codes, but their uptake remained low. Audio-only telemedicine appears to offer an important means for access to behavioral health and perinatal care access, but further work is needed to study outcomes and quality of care.
18F-FDG and 18F-AIF-NOTA-Octreotide PET/CT Confirmed a Rare Case of Cutaneous Merkel Cell Carcinoma With a Solitary Local Nodal Metastasis
Authors: Yanxia Mi, Yuan Jia, Dongni Du, Yong Du, Ming Zhao
Journal: Clinical Nuclear Medicine (2023)

Abstract Cutaneous Merkel cell carcinoma with local nodal metastasis is a rare entity. A 56-year-old man presented with a nontender left inguinal mass, and ultrasound-guided biopsy of this nodal mass confirmed nodal metastasis with strong neuroendocrine differentiation from cutaneous Merkel cell carcinoma. Staging 18 F-FDG PET/CT showed a solitary 3.9 × 6.8-cm hypermetabolic left groin mass with no other suspicious lesions elsewhere. To confirm the patient’s eligibility for radical curative treatment, taking into consideration of its neuroendocrine differentiation, a subsequent 18 F-AIF-NOTA-octreotide PET/CT was performed, which demonstrated only solitary somatostatin receptor–positive left inguinal mass. The patient underwent radical treatment.
Intermittent Wolff-Parkinson-White Syndrome Mimicking a Ventricular Tachycardia
Authors: Herman Chih-Heng Chang, Chun-Lin Chen, Huey-Ming Lo
Journal: JAMA Internal Medicine (2023)

This case report describes a patient in their 50s with a history of pneumoconiosis and chronic obstructive pulmonary disease who presented to the emergency department with sudden onset shortness of breath.
Health Care Workers and War in the Middle East
Authors: Michael Gallagher
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Workers at Risk of Silicosis—Ongoing Overexposure and Lack of Medical Surveillance
Authors: Michael J. Hodgson, Philip A. Smith
Journal: JAMA Internal Medicine (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Letter to the editor: Scavenger receptor a is a major homeostatic regulator that restrains drug-induced liver injury
Authors: Qi Wang, Qingfa Bu, Bozhou Pan, Yin Yin, Lei Liu
Journal: Hepatology (2023)

To the editor, We read the recent article by Guo et al,1 reporting that scavenger receptor A (SRA) depletion caused mice highly susceptible to drug hepatotoxicity, which revealed that SRA deficiency exacerbated DILI and hepatic inflammation by decreasing anti-inflammatory cytokine IL-10 production. It is really an interesting study which deeply impresses us. Nevertheless, there are some concerns requiring attention in this study. First, SRA, an important member of the scavenger receptors family, is a multiligand and multifunctional receptor expressed on macrophages and has been suggested to play an important role in mediating phagocytosis of different types of antigens.2 The current study did not further explore the effect of SRA-mediated phagocytosis on DILI. Damaged hepatocytes in DILI could be cleared by macrophage phagocytosis.3 Thus, whether SRA-mediated phagocytosis affects the progression of DILI should also be further investigated. Second, cytokines secreted by immune cells play an important role in DILI. This study evaluated the levels of various cytokines, such as TNF-α, IFN-γ, IL-17A, and IL-10. Considering that SRA is primarily expressed in macrophages, more cytokines secreted by macrophages may need to be detected, such as IL-1β, IL-6, IL-12, and TGF-β.4 Third, this study demonstrated the hepatoprotective SRA-IL-10 axis in kupffer cells against DILI. Another study indicated that IL-10 reduced the oxidized low density lipoprotein-induced lipoprotein uptake and apoptosis partly via downregulating the oxidized low density lipoprotein-induced SRA mRNA expression in Tohoku Hospital Pediatrics-1–derived macrophages.5 Thus, the specific mechanisms of how SRA promoted IL-10 secretion in this study remain obscure, and deserves further study. Collectively, we agree with the investigators' conclusion that SRA restrains DILI by promoting anti-inflammatory and prosurvival cytokine IL-10 production. However, further studies are required to determine whether SRA-mediated phagocytosis in macrophages affects DILI, whether SRA could regulate other anti-inflammatory cytokines except IL-10, and the specific mechanisms of how SRA promotes IL-10 production.