AB0787 A MULTICENTRIC DESCRIPTIVE STUDY OF 360 PATIENTS OF SARCOIDOSIS IN KARNATAKA, SOUTH INDIA: A RHEUMATOLOGISTS’ PERSPECTIVE
Authors: S. R, S. Prasad, S. Chandrashekara, V. Shobha, S. Kumar, V. K. R. Rao, A. Patil, V. Haridas, N. Srinivasulu, S. C, P. Patil, V. R. K. Jain, P. Chebbi, H. Alur Shivakumar, S. Kn, P. Bafna, P. Jaladhar, P. Gowda, M. Mahabaleshwar, V. A. D. Ponnuru
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Majority of the Sarcoid series are from Pulmonology centers rather than Rheumatology centers. The ACCESS study quoted commonly in review articles and text books has been described from Pulmonology centers. This multicentric study was undertaken to enumerate the clinical, radiological and pathological aspects of patients of Sarcoidosis presenting to the Rheumatology OPD <h3>Objectives:</h3> To describe the Clinical, Radiological and pathological manifestations of Sarcoidosis presenting to the Rheumatology OPD <h3>Methods:</h3> It is a Retro-prospective cross sectional descriptive study of Sarcoidosis from 17 centers in Karnataka, South India. The diagnosis of Sarcoidosis was confirmed either by Clinico – serological, Clinico – radiological or Clinico – pathological co-relation. Descriptive data was collected regarding diagnosis, clinical presentation, organ involvement, radiological findings, serological investigations and histopathology <h3>Results:</h3> Data of 360 patients from 17 centers across Karnataka, South India were collected over a period of 24 months. The study (Table 1) had 236 female patients, with mean age at presentation being 48.99 (7-92) years and mean duration of symptoms being 33. 89(0.25 - 432) months. 58 patients had single organ involvement and 302 patients had systemic disease. Arthritis/ arthralgia was seen in 162(45%) patients (oligoarticular-41 and polyarticular-38), Respiratory symptoms were seen in 114 (31.7%) patients, Ophthalmic symptoms in 120(33.3%) patients, 121(33.6%) patients had Dermatological manifestations and 39 (10.8%) patients presented with neurological manifestations. Cardiac sarcoid was identified in 17(4.7%) patients (Tachyarrhythmia-10 &amp; bradyarrhythmia-7). Peripheral lymphadenopathy was the presenting feature in 62(17.2%) patients. Renal manifestations included Nephrolithiasis (4), Nephrocalcinosis(5), renal insufficiency (15) and interstitial nephritis (4). Syndromic presentations as Lofgren's (18) and Heerfordt's (4) were observed. Chest radiograph was abnormal in 158 patients. 221 patients with Chest CT had lymphadenopathy and 199 parenchymal involvement. Histopathological diagnosis (Graph 1) was available in 170 (47.2%) cases out of which 147 cases (86.5%) had systemic manifestations. Lymph node (84), skin (38), glandular (11), and Liver (8) were commonly biopsied organs. 46 cases (24.2%) of single organ involvement had radiological/ serological findings. S. ACE levels was elevated in 216 (67.9%) patients (n = 318), in which 14.8% (32) had single organ involvement. Mantoux was negative in 143 patients and Quantiferon gold was negative in 88 patients. 42 patients had received Antitubercular therapy before presenting to the Rheumatologist in whom investigations for tuberculosis were negative <h3>Conclusion:</h3> Our study had numerically higher percentage of patients with single organ involvement as compared to other studies and differs in specific organ manifestations. Rheumatology centered evaluation may have attributed to this variation. Majority of the patients with single organ involvement required Histopathology and/or S. ACE levels for diagnosis. Limitations: Investigation data was not completely retrievable. Clinical data was available in all the cases. <h3>REFERENCES:</h3> <b>NIL.</b> <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>