tbuckley/cabot-search huggingface dataset:
Three-dimensional genome landscape of primary human cancers
Authors: Kathryn E Yost, Yanding Zhao, King L Hung, Kaiyuan Zhu, Duo Xu, M Ryan Corces, Shadi Shams, Bryan H Louie, Shahab Sarmashghi, Laksshman Sundaram, Jens Luebeck, Stanley Clarke, Ashley S Doane, Jeffrey M Granja, Hani Choudhry, Marcin Imieliński, Andrew D Cherniack, Ekta Khurana, Vineet Bafna, Ina Felau, Jean C Zenklusen, Peter W Laird, Christina Curtis, William J Greenleaf, Howard Y Chang
Journal: Nature Genetics (2025)
Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer
Authors: Theodore J Sanders, Christopher S Nabel, Margreet Brouwer, Annelise L Hermant, Lucas Chaible, Jean-Philippe Deglasse, Nicolas Rosewick, Angélique Pabois, Wilfried Cathou, Aurore Smets, Michael Deligny, João Marchante, Quentin Dubray, Marie-Claire Letellier, Chiara Martinoli, Reece Marillier, Olivier De Henau, Yvonne McGrath, Matthew G Vander Heiden, Erica Houthuys
Journal: Nature Immunology (2025)
Biological markers and psychosocial factors predict chronic pain conditions
Authors: Matt Fillingim, Christophe Tanguay-Sabourin, Marc Parisien, Azin Zare, Gianluca V Guglietti, Jax Norman, Bogdan Petre, Andrey Bortsov, Mark Ware, Jordi Perez, Mathieu Roy, Luda Diatchenko, Etienne Vachon-Presseau
Journal: Nature Human Behaviour (2025)
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging
Authors: Seyed Soheil Saeedi Saravi, Benoit Pugin, Florentin Constancias, Khatereh Shabanian, Marianne Spalinger, Aurélien Thomas, Sylvain Le Gludic, Taraneh Shabanian, Gergely Karsai, Manuel Colucci, Cristina Menni, Ilias Attaye, Xinyuan Zhang, Meret Sarah Allemann, Pratintip Lee, Alessia Visconti, Mario Falchi, Andrea Alimonti, Frank Ruschitzka, Francesco Paneni, Jürg H Beer
Journal: Nature Aging (2025)
Simultaneous Volumetric and Functional Right Ventricular Assessment by Principal Strain Analysis in Children with Repaired Tetralogy of Fallot
Authors: Daisuke Matsubara, Ryusuke Numata, Renzo Calderon-Anyosa, Hunter L Kauffman, David M Biko, Gianni Pedrizzetti, Anirban Banerjee
Journal:  (2025)

Abstract Background Principal strain (PS)-analysis using three-dimensional speckle-tracking echocardiography enables us to simultaneously measure 3D-ventricular volumes and strains. PS quantifies 3D-deformation by defining not only amplitude but also direction of principal myocardial contraction (PS-angle). Objectives 1) To validate volumetric and functional parameters using PS-analysis in volume-overloaded RV of repaired-tetralogy of Fallot (rTOF) versus cardiac magnetic resonance (CMR), and 2) to describe PS-analysis indices in patients undergoing pulmonary valve replacement (PVR). Methods Sixty-four pediatric patients with rTOF (12.4 ± 5.2 years) and 58 age-matched healthy children (12.8 ± 3.7 years) were prospectively included. We calculated PS-magnitude (global PS: GPS) and -angle, indexed RV end-diastolic and end-systolic volumes (EDVi and ESVi), RV ejection fraction (EF), and conventional strains. Among rTOF patients, 32 CMR were available. First, we validated volumetric-parameters obtained by PS-analysis against CMR. Second, we compared these indices between rTOF patients and controls. Lastly, we evaluated the discriminative-value of PS-analysis in PVR. Results PS-analysis and CMR measurements showed good correlations (EDVi, r =0.80; ESVi, r=0.74; and EF, r=0.70, p&amp;lt;0.001). GPS showed the highest correlation with 3D-EF (r=-0.84, p&amp;lt;0.001). rTOF patients exhibited nearly doubled RV-volume and significantly decreased 3D-EF and conventional strains. PS-magnitude also decreased in rTOF patients, with altered PS-angles in RV-free wall. Volume measurements of RV showed the highest predictive value for discriminating PVR(+) by ROC analysis, followed by PS-functional parameters. Conclusions PS-analysis is a reliable and reproducible method for both volumetric and functional analysis of volume-overloaded RV in rTOF, which can be of incremental value for defining the indications for PVR.
Baseline Hemoglobin Values and Clinical Outcomes in Acute Venous Thromboembolism: Insights From the <scp>RIETE</scp> Registry
Authors: Carmine Siniscalchi, Pierpaolo Di Micco, Antonella Tufano, Maria Luisa Peris, Patricia López‐Miguel, Alicia Alda‐Lozano, Pilar Llamas, Diego Durán Barata, Yaser Jenab, Manuel Monreal
Journal: American Journal of Hematology (2025)
Solitary Radius Metastasis as the First Presentation of Renal Cell Carcinoma Revealed by Bone Scintigraphy
Authors: Huan Liang, Yanbin Bai, Wenjun Bao, Lingge Wei, Peng Xie
Journal: Clinical Nuclear Medicine (2025)

Solitary radius metastasis as the initial presentation of renal cell carcinoma is extremely rare. Here we present the bone scintigraphy findings of a 72-year-old man who complained of left wrist pain for 6 months. The 99m Tc-MDP bone scintigraphy demonstrated intense ring-like MDP uptake in the distal left radius. Finally, solitary radius metastasis from renal cell carcinoma was confirmed.
Application of 99mTc-FAPI-46 SPECT/CT in Evaluation of Idiopathic Retroperitoneal Fibrosis: Case Report of a Novel Promising Experience
Authors: Nasrin Raeisi, Amin Saber Tanha, Ehsan Soltani, Kamran Aryana, Atena Aghaee
Journal: Clinical Nuclear Medicine (2025)

This case report describes a 59-year-old man with fatigue and bilateral lower limb edema, diagnosed with retroperitoneal fibrosis (RPF). Laboratory tests showed elevated serum creatinine, ESR, and CRP levels, while imaging revealed left hydroureteronephrosis and a pelvic mass encasing the iliac vessels. A biopsy indicated fibrotic changes without malignancy, confirming RPF. This experience of using 99m Tc-FAPI-46 as a novel agent for conventional imaging demonstrated a high target-to-background ratio in the RPF, suggesting its utility in diagnosis and assessing disease activity, also aiding in ruling out the distant malignant neoplasms, especially where PET/CT is not available.
Favorable 99mTc-FAPI-46 Uptake in Primary Mucinous Adenocarcinoma of the Bladder
Authors: Nasrin Raeisi, Amin Saber Tanha, Alireza Khooei, Naime Ataei, Atena Aghaee
Journal: Clinical Nuclear Medicine (2025)

We present a 34-year-old woman diagnosed with primary mucinous adenocarcinoma of the bladder, confirmed after transurethral resection. Two years postinitial diagnosis, despite chemotherapy, she developed pulmonary and skeletal metastases, leading to progressive symptoms including cough, hemoptysis and refractory bone pain. She was evaluated via 99m Tc-FAPI-46 scintigraphy, which showed significant uptake in metastatic lesions, suggesting suitability for radio-ligand therapy. However, the patient’s condition deteriorated rapidly, and she passed away before treatment could be initiated. This case underscores the sensitivity of FAPI-targeted imaging in mucinous adenocarcinoma of the bladder and highlights the need for further investigation into its therapeutic applications.
Incidental Detection of Renal Cell Carcinoma on 18F-NOTA-Pentixather PET/CT in a Patient With Aldosterone-producing Adenoma
Authors: Lijuan Feng, Hao Wang, Wei Zhang
Journal: Clinical Nuclear Medicine (2025)

We report the 18 F-NOTA-pentixather PET/CT findings of aldosterone-producing adenoma (APA) coincidence with renal cell carcinoma (RCC) in a 36-year-old man. He went to the hospital for persistent hypertension and new limb numbness and weakness. CT showed a nodule in the left adrenal gland, suggestive of an adenoma. 18 F-NOTA-pentixather PET/CT showed the nodule with high NOTA-pentixather uptake. A surprisingly NOTA-pentixather-avid lesion in the right kidney was also noted. Postoperative pathology supported a diagnosis of APA of the left adrenal gland nodule, and the right kidney lesion was RCC.
Impact of Therapeutic Radioactive Iodine on the Recurrence of Papillary Thyroid Cancer With Extranodal Extension in Metastatic Lymph Nodes: A Propensity Score-matched Analysis
Authors: Hye In Kim, Boram Kim, Jiyeon Hyeon, Nak Gyeong Ko, Mihyeon Jin, Jung Hwan Cho, Ji Min Han, Sunghwan Suh, Ji Cheol Bae, Man Ki Chung, Jun-Ho Choe, Sun Wook Kim, Jae Hoon Chung, Young Lyun Oh, Kyunga Kim, Tae Hyuk Kim, Joon Young Choi
Journal: Clinical Nuclear Medicine (2025)

Purpose: Radioactive iodine therapy (RAI) ≥100 mCi (3.7 GBq) is commonly recommended for papillary thyroid cancer (PTC) patients with extranodal extension (ENE). However, no study has evaluated whether RAI ≥100 mCi is effective in reducing the recurrence of PTC with ENE. Methods: This retrospective cohort study enrolled 191 PTC patients with ENE who underwent total thyroidectomy and RAI. Recurrence according to RAI activity (&lt;100 vs. ≥100 mCi) was compared before and after propensity score matching (PSM) (1:2) using Kaplan-Meier curves and Cox proportional hazards regression models. Subgroup analyses according to mass size (&lt;4 and ≥4 cm), gender, blood vessel invasion, lymph node (LN) number (≤5 and &gt;5), and stimulated Tg (sTg) level (&lt;10 and ≥10 ng/mL) before and after PSM were performed. Results: During about 116 months, 5 (12.5%) and 19 (12.6%) before PSM, five (12.5%) and 3 (3.8%) after PSM recorded recurrence in &lt;100 and ≥100 mCi groups, respectively. The impact of RAI ≥100 mCi on reducing recurrence was not significant before [log-rank P = 0.915, adjusted hazard ratio (HR) 0.49 (0.12–1.85); P = 0.294) and after PSM (log-rank P = 0.077). Subgroup analysis after PSM demonstrated the impact of RAI ≥100 mCi on lowering recurrence only in ENE patients with mass size ≥4 cm (log-rank P = 0.008), LN &gt;5 (log-rank P = 0.007), and sTg ≥10 ng/mL (log-rank P = 0.039). Conclusions: In PTC patients with ENE, mass size ≥4 cm, LN &gt;5, or sTg ≥10 ng/mL had a benefit from RAI ≥100 mCi compared with RAI &lt;100 mCi.
Mild Metabolism Increase on Posttreatment 18F-FDG PET may Indicate Recurrence of Primary CNS Lymphoma
Authors: Antoine Rogeau, Sylvain Choquet, Bertrand Mathon, Magali Le Garff-Tavernier, Karima Mokhtari, Lucia Nichelli, Inès Boussen, Laura Rozenblum, Caroline Houillier, Aurélie Kas
Journal: Clinical Nuclear Medicine (2025)

In immunocompetent patients, primary central nervous system lymphoma (PCNSL) typically presents with homogeneously enhancing brain lesions and high 18 F-FDG avidity, ranging from 2 to 5 times higher than that of healthy tissue at baseline. We present the case of a 34-year-old woman in whom PCNSL recurrence was questioned due to the appearance of mildly increased glucose metabolism (1.3 times higher than normal contralateral tissue) and FLAIR hypersignals, despite the absence of contrast enhancement or cerebrospinal fluid abnormalities. Histopathology confirmed the recurrence. This case highlights that new 18 F-FDG PET uptake during follow-up, even with lower avidity than baseline, should prompt concern for recurrence or residual disease in PCNSL.
Comparable Diagnostic Value of 99mTc-FAPI-46 SPECT/CT and 18F-FDG PET/CT in Cholangiocarcinoma: A Case Report
Authors: Nasrin Raeisi, Amin Saber Tanha, Mitra Ghahraman, Kamran Aryana, Atena Aghaee
Journal: Clinical Nuclear Medicine (2025)

We describe a 51-year-old man with cholangiocarcinoma of the common bile duct. Initially deemed nonmetastatic, he was a candidate for curative surgery and liver transplantation. However, during laparotomy, peritoneal seeding was discovered, necessitating omentectomy and lesion resection. Following chemotherapy, the patient underwent 18 F-FDG PET/CT for re-staging, revealing uptake in the primary tumor and a right iliac bone metastasis. Subsequently, FAPI-based scintigraphy using 99m Tc-FAPI-46 as a novel conventional imaging agent demonstrated comparable uptake in both lesions. This case highlights the diagnostic potential of 99m Tc-FAPI-46 SPECT/CT as an alternative to 18 F-FDG PET/CT and 68 Ga-FAPI in cholangiocarcinoma, particularly in resource-limited settings.
Neural Network-based Automated Classification of 18F-FDG PET/CT Lesions and Prognosis Prediction in Nasopharyngeal Carcinoma Without Distant Metastasis
Authors: Yuhu Lv, Danzha Zheng, Ruiping Wang, Zhangyongxue Zhou, Zairong Gao, Xiaoli Lan, Chunxia Qin
Journal: Clinical Nuclear Medicine (2025)

Purpose: To evaluate the diagnostic performance of the PET Assisted Reporting System (PARS) in nasopharyngeal carcinoma (NPC) patients without distant metastasis, and to investigate the prognostic significance of the metabolic parameters. Patients and Methods: Eighty-three NPC patients who underwent pretreatment 18 F-FDG PET/CT were retrospectively collected. First, the sensitivity, specificity, and accuracy of PARS for diagnosing malignant lesions were calculated, using histopathology as the gold standard. Next, metabolic parameters of the primary tumor were derived using both PARS and manual segmentation. The differences and consistency between the 2 methods were analyzed. Finally, the prognostic value of PET metabolic parameters was evaluated. Prognostic analysis of progression-free survival (PFS) and overall survival (OS) was conducted. Results: PARS demonstrated high patient-based accuracy (97.2%), sensitivity (88.9%), and specificity (97.4%), and 96.7%, 84.0%, and 96.9% based on lesions. Manual segmentation yielded higher metabolic tumor volume (MTV) and total lesion glycolysis (TLG) than PARS. Metabolic parameters from both methods were highly correlated and consistent. ROC analysis showed metabolic parameters exhibited differences in prognostic prediction, but generally performed well in predicting 3-year PFS and OS overall. MTV and age were independent prognostic factors; Cox proportional-hazards models incorporating them showed significant predictive improvements when combined. Kaplan-Meier analysis confirmed better prognosis in the low-risk group based on combined indicators (χ² = 42.25, P &lt; 0.001; χ² = 20.44, P &lt; 0.001). Conclusions: Preliminary validation of PARS in NPC patients without distant metastasis shows high diagnostic sensitivity and accuracy for lesion identification and classification, and metabolic parameters correlate well with manual. MTV reflects prognosis, and its combination with age enhances prognostic prediction and risk stratification.
FDG PET/CT Image of Extrarenal Wilms Tumor of Cervix
Authors: Ali Kibar, Onur Erdem Sahin, Haluk Burcak Sayman
Journal: Clinical Nuclear Medicine (2025)

Wilms tumor is a rare type of cancer that mainly affects children. It’s the most common cancer of the kidneys in children. Although it is usually seen under the age of 3, it can also be diagnosed at older ages. Extrarenal Wilms tumor (ERWT) is very rare, comprising &lt;1% of all Wilms tumor cases. It is most commonly seen in the retroperitoneum and pelvic region and has been reported in a limited number of patients in the literature. This report presents a patient with ERWT of the cervix who underwent FDG PET/CT imaging.
Prostate Adenocarcinoma Recurrence in the Vas Deferens Unveiled by 99mTc-PSMA SPECT/CT Imaging
Authors: Nasrin Raeisi, Amin Saber Tanha, Ramin Sadeghi, Masoumeh Dorri Giv, Vahid Reza Dabbagh Kakhki
Journal: Clinical Nuclear Medicine (2025)

We present a case involving a 77-year-old man with prostate cancer who underwent radical prostatectomy with negative surgical margins. After 10 years without follow-up, his serum prostate-specific antigen level increased to 2.76 ng/mL, suggesting disease recurrence. Due to limited access to 68 Ga-PSMA PET/CT, a 99m Tc-HYNIC-PSMA SPECT/CT was conducted, which identified PSMA uptake in the bilateral vas deferens, a rare site for recurrence. While recurrence in the vas deferens has been previously reported using 68 Ga-PSMA PET/CT or PET/MR, this novel experience with 99m Tc-PSMA SPECT/CT highlights its potential utility in detecting such recurrences. This is particularly relevant in low-income countries where access to PET/CT may be limited.
Rod‐shaped Polymerized Salicylic Acid Particles Modulate Neutrophil Transendothelial Migration in Acute Inflammation
Authors: M. Valentina Guevara, Emma R. Brannon, Daniel Kupor, Mariana R.N. Lima, Logan D. Piegols, Michael L. Felder, Kathryn E. Uhrich, Omolola Eniola‐Adefeso
Journal: Advanced Healthcare Materials (2025)

Abstract Neutrophilic inflammation is present in numerous high‐mortality pathologies, including sepsis, deep vein thrombosis, and acute lung injury (ALI). Therefore, regulating neutrophil recruitment becomes an attractive therapeutic approach for neutrophil‐mediated inflammation. Here, the impact of salicylic acid‐based polymeric particles in regulating neutrophil recruitment in vivo and in vitro, particularly investigating the impact of neutrophil targeting via particle geometry‐driven phagocytosis is explored. It is found that rod‐shaped polymeric particles can improve neutrophil targeting in a murine ALI model, effectively preventing neutrophil infiltration into the mice's lungs compared to spherical particles of the same volume. It is demonstrated that the elongated nature of the polymeric carriers reduced neutrophils’ transmigration ability across endothelial barriers in vivo and in vitro, contributing to their therapeutic effectiveness. These data represent initial work in developing non‐spherical particle‐mediated targeting of activated neutrophils for conditions affected by neutrophilic injury.
A Nanoplatform Targeting Cascade Pathways for Enhanced Triptolide Delivery in Acute Kidney Injury Therapy
Authors: Qianqian Guo, Xin Lu, Yanqi Zhang, Zhimin Huang, Shaobo Liu, Li Qiao, Xingjie Wu, Honglei Guo, Xiangchun Shen, Huijuan Mao
Journal: Advanced Healthcare Materials (2025)

Abstract Triptolide (TP), the main active compound in Tripterygium wilfordii Hook F, has anti‐inflammatory and antioxidant properties, making it a potential treatment option for acute kidney injury (AKI). However, the application of TP faces challenges due to its poor water solubility, low renal accumulation, and potential tissue toxicity. To overcome these limitations, TL‐N@TP is engineered as a cascade‐targeted nanotherapeutic system integrating triphenylphosphonium (TPP)‐ and lysozyme (LZM)‐functionalized PEG‐PLGA copolymers for renal‐specific TP delivery. The effectiveness of TL‐N@TP is highlighted through a tripartite targeting mechanism, involving glomerular filtration, renal tubule specificity, and mitochondrial localization. The nanoplatform is able to target damaged kidneys and localize in the renal tubular cells in AKI mice induced by lipopolysaccharide. Upon uptake by injury HK‐2 cells, the nanoplatform showed antioxidant, anti‐inflammatory, and antiapoptotic effects. The nanoplatform in AKI mice effectively improved renal function by facilitating the restoration of mitochondrial structure and function, concomitant with reducing oxidative stress and inflammation. These findings establish TL‐N@TP as a promising nanotherapeutic strategy for AKI management.
Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium
Authors: Christine Lansche, Ségolène Ladaigue, Giacomo Gropplero, Nicolas Zimmermann, Martin Nurmik, Irina Veith, Manh‐Louis Nguyen, Solenn Brosseau, Nicolas Poté, Pierre Mordant, Arnaud Roussel, Fathia Mami‐Chouaib, Fatima Mechta‐Grigoriou, Gérard Zalcman, Fabrice Soncin, Stéphanie Descroix, Maria Carla Parrini
Journal: Advanced Healthcare Materials (2025)

Abstract The endothelium compartment is a key player in tumor initiation and progression, but most existing tumor‐on‐chip models lack clinical relevance. Here, a 3D vascularized tumor‐on‐chip (vToC) model, generated with patient‐derived microvascular endothelial cells (ECs) that are freshly isolated from surgical lung cancer samples, is presented. The microvessel molecular identity, morphology, and functionality are assessed by transcriptomic, immunofluorescence, TNF‐α stimulation, and permeability assays. Lung cancer cells, cancer‐associated fibroblasts (CAFs), and CD8+ tumor‐infiltrating lymphocytes are embedded into the surrounding collagen matrix to partially recapitulate the lung tumor microenvironment (TME). The proof‐of‐concept of feasibility to generate personalized immunocompetent vToC composed of primary fully autologous cell types is provided. This vToC model is used to investigate the interplay between ECs and other TME cellular components by transcriptomic analysis. Using a rationally designed panel of endothelial genes, it is found that the presence of cancer cells and CAFs in the endothelial environment decreases expression by ECs of VCAM‐1 leukocyte adhesion protein, a crucial regulator of immune infiltration, and of many immunomodulatory chemokines, recapitulating endothelial cell anergy. This in vitro model will be a valuable clinically‐relevant tool to study the tumor‐CAF‐immune–endothelium interplay.
Evaluation of the Therapeutic Response and Recurrence by 18F-FLT PET in a Case of Central Nervous System-Lymphomatoid Granulomatosis
Authors: Katsuya Mitamura, Takashi Norikane, Yuri Manabe, Yuka Yamamoto, Keisuke Miyake, Yoshihiro Nishiyama
Journal: Clinical Nuclear Medicine (2025)

A 78-year-old man visited our hospital complaining of cognitive decline and gait disturbance. MRI revealed multiple nodular enhancing lesions in the brain. He was pathologically diagnosed with central nervous system-lymphomatoid granulomatosis (CNS-LYG) by brain biopsy. Brain PET examinations using 18 F-fluorothymidine (FLT) PET and 11 C-methionine (MET) PET were performed. Strong accumulation in the lesions was observed with 18 F-FLT PET. After treatment, the accumulation of lesions disappeared, and accumulation was observed again at the time of recurrence. In contrast, 11 C-MET PET showed unclear accumulation in the lesions both before therapy and at recurrence. 18 F-FLT uptake was likely reflecting the degree of cell infiltration and the disrupted blood-brain barrier. 18 F-FLT PET might be a useful tool for evaluating the therapeutic response and recurrence of CNS-LYG.
PSMA Radioligand Therapy in Advanced Age
Authors: Moritz B. Bastian, Benedikt Wörl, Arne Blickle, Caroline Burgard, Tilman Speicher, Joel Wessendorf, Mark Bartholomä, Andrea Schaefer-Schuler, Stephan Maus, Samer Ezziddin, Florian Rosar
Journal: Clinical Nuclear Medicine (2025)

Purpose: With increasing life expectancy, the number of older patients with metastatic castration-resistant prostate cancer (mCRPC) continues to rise, but this group is currently underrepresented in clinical trials. This study aims to assess the efficacy and safety of prostate-specific membrane antigen (PSMA) targeted radioligand therapy (RLT) in patients over 85 years old with mCRPC. Materials and Methods: A retrospective analysis was conducted on 21 mCRPC patients aged 85 years or older receiving PSMA-RLT (range: 85–96 y). The median number of treatment cycles was 4 (range: 1–13 cycles), with a mean cumulative administered activity of 26.9±17.3 GBq (range: 8.0–87.2 GBq) of [ 177 Lu]Lu-PSMA-617. Adverse events, including anemia, thrombocytopenia, leukopenia, renal impairment, fatigue, and xerostomia were classified according to CTCAE version 5.0. Results: The mean best PSA response across the cohort was –37.6±73.3%, with 62% (13 of 21 patients) showing partial remission. Median progression-free survival and overall survival were 4.6 and 14.7 months, respectively. Severe adverse events were rare, occurring in 2 patients: 1 case of grade 3 anemia and 1 of grade 3 thrombocytopenia. Conclusions: The results demonstrate that PSMA-RLT is an effective and well-tolerated treatment for mCRPC patients over 85 years, with clinical outcomes and safety comparable to those observed in studies involving younger populations. This highlights its potential as a valuable therapeutic option for this aging patient group.