tbuckley/cabot-search huggingface dataset:
Retrograde endoscopic ultrasound-guided entero-enterostomy for the management of a high-output enterocutaneous fistula and ileal stricture in a complex surgical abdomen
Authors: Sunil Gupta, Eimear Kirby, Sarang Gupta, Katarzyna M. Pawlak, Joao De Rezende-Neto, Jeffrey D. Mosko, Natalia C. Calo
Journal: Endoscopy (2024)

A 26-year-old man sustained significant traumatic thoracoabdominal injuries following a gunshot. After multiple laparotomies, small-bowel resections, and an extended left hemicolectomy with end-colostomy formation, he developed a high-output enterocutaneous fistula (ECF) and loss of colostomy output. Computed tomography imaging confirmed an ECF from the ileum to the anterior abdominal wall. There was also a long ileal stricture distal to the fistula. Owing to his complex surgical abdomen and the proximity of the ECF to an abdominal flap, surgical reintervention was deemed high risk. He was therefore referred for endoscopic management ([Video 1]).
Association of nirmatrelvir–ritonavir with post-acute sequelae and mortality among patients who are immunocompromised with COVID-19 in Hong Kong: a retrospective cohort study
Authors: Guozhang Lin, Yuchen Wei, Huwen Wang, Christopher Boyer, Katherine Min Jia, Chi Tim Hung, Xiaoting Jiang, Conglu Li, Carrie Ho Kwan Yam, Tsz Yu Chow, Yawen Wang, Shi Zhao, Zihao Guo, Kehang Li, Aimin Yang, Chris Ka Pun Mok, David S C Hui, Ka Chun Chong, Eng Kiong Yeoh
Journal: The Lancet Rheumatology (2024)
Variations in antenatal management and outcomes in haemolytic disease of the fetus and newborn: an international, retrospective, observational cohort study
Authors: Derek P de Winter, Enrico Lopriore, Emilie Thorup, Olav Bjørn Petersen, Morten H Dziegiel, Karin Sundberg, Roland Devlieger, Luc de Catte, Liesbeth Lewi, Anne Debeer, Véronique Houfflin-Debarge, Louise Ghesquiere, Charles Garabedian, Kévin Le Duc, Eugenia Antolin, Nieves Mendez, James Castleman, Wing Ting Tse, Jean-Marie Jouannic, Paul Maurice, Jane Currie, Emma Mullen, Lut Geerts, Kerry Rademan, Asma Khalil, Borna Poljak, Smriti Prasad, Eleonor Tiblad, Kajsa Bohlin, Annegret Geipel, Johanna Rath, Fergal Malone, David Mackin, Yoav Yinon, Stav Cohen, Greg Ryan, Evangelia Vlachodimitropoulou, Karl-Philipp Gloning, Stefan Verlohren, Beate Mayer, Mariano Lanna, Stefano Faiola, Tanja Premru Sršen, Lilijana Kornhauser Cerar, Saul Snowise, Luming Sun, Lucas Otaño, César Hernan Meller, Ngina K Connors, Matthew Saxonhouse, Aline Wolter, Ivonne Bedei, Philipp Klaritsch, Sarah Jauch, Eduardo Teixeira da Silva Ribeiro, Fernando Maia Peixoto Filho, Raigam Jafet Martinez-Portilla, Alexandra Matias, Obdulia Alejos Abad, Juan Parra Roca, Ángel Guillermo Alcázar Grisi, Edgar Juan José Chávez Navarro, Johanna G van der Bom, Masja de Haas, Ejt Joanne Verweij
Journal: The Lancet Haematology (2024)
Betibeglogene autotemcel gene therapy in patients with transfusion-dependent, severe genotype β-thalassaemia (HGB-212): a non-randomised, multicentre, single-arm, open-label, single-dose, phase 3 trial
Authors: Janet L Kwiatkowski, Mark C Walters, Suradej Hongeng, Evangelia Yannaki, Andreas E Kulozik, Joachim B Kunz, Martin G Sauer, Adrian J Thrasher, Isabelle Thuret, Ashutosh Lal, Ge Tao, Shamshad Ali, Himal L Thakar, Heidi Elliot, Ankit Lodaya, Ji Lee, Richard A Colvin, Franco Locatelli, Alexis A Thompson
Journal: The Lancet (2024)
Removal of jammed loop cutter and residual snare wire, after polypectomy with a detachable snare
Authors: Kei Nakazawa, Yuki Hirata, Ryoji Koshiba, Kazuki Kakimoto, Takako Miyazaki, Shiro Nakamura, Hiroki Nishikawa
Journal: Endoscopy (2024)

Detachable snares, which are tightened around the polyp base during the resection of pedunculated polyps, are very useful for preventing bleeding during polypectomy [1] [2] [3]. However, unexpected situations are occasionally encountered when using detachable snares. Here, we present a case in which, after ligation with a detachable snare, the excess snare wire became wedged through the loop cutter, jamming it so that its cutting mechanism could not be opened or closed.
Successful necrosectomy using the over-the-scope grasping device: a tool for solid necrotic debris
Authors: Rahul Karna, Suchapa Arayakarnkul, Natalie Wilson, Mohammad Bilal
Journal: Endoscopy (2024)

Direct endoscopic necrosectomy (DEN) can be a challenging procedure in patients with a large amount of necrotic debris. Traditionally, DEN has been performed with a combination of snares, baskets, forceps, and suction with intermittent irrigation. These instruments were not designed for necrosectomy and often slip off the necrotic tissue, making DEN cumbersome [1]. An over-the-scope (OTS) grasping device (OTSG Xcavator; Ovesco Endoscopy AG, Tübingen, Germany) has been designed for removal of necrotic tissue, facilitated by the extra-large grasper attached to the tip of the endoscope [2]. Here, we describe a case in which DEN was efficiently performed using the OTS grasping device.
Application of through-the-scope twin clip for semicircumferential defect closure after rectal laterally spreading tumor transanal super minimally invasive surgery resection
Authors: Chenyang Li, Ningli Chai, Tao Wang, Shuling Li, Fuxiu Huang, Ningning Zhang, Chao Chen
Journal: Endoscopy (2024)

With increasing defect depth and size, the complexity of closure intensifies. While the over-the-scope clip is a favored approach for larger defects, it encounters challenges such as pre-procedure attachment. This requirement can prolong surgical time and raise the risk of postoperative complications, including peritonitis [1].
Accuracy of Xpert and alternative sampling methods to diagnose childhood pulmonary tuberculosis, a prospective cohort study
Authors: Lou Macaux, Voahangy Rasolofo, Sara Eyangoh, Kouassi Raymond N'Guessan, Mathurin Cyrille Tejiokem, Niaina Rakotosamimanana, Man-Koumba Soumahoro, Simon Cauchemez, Rindra Vatosoa Randremanana
Journal: Clinical Microbiology and Infection (2024)
Laparoscopy-assisted versus open surgery for low rectal cancer (LASRE): 3-year survival outcomes of a multicentre, randomised, controlled, non-inferiority trial
Authors: Weizhong Jiang, Jianmin Xu, Ming Cui, Huizhong Qiu, Ziqiang Wang, Liang Kang, Haijun Deng, Weiping Chen, Qingtong Zhang, Xiaohui Du, Chunkang Yang, Yincong Guo, Ming Zhong, Kai Ye, Jun You, Dongbo Xu, Xinxiang Li, Zhiguo Xiong, Kaixiong Tao, Kefeng Ding, Weidong Zang, Yong Feng, Zhizhong Pan, Aiwen Wu, Feng Huang, Ying Huang, Ye Wei, Xiangqian Su, Pan Chi
Journal: The Lancet. Gastroenterology & hepatology (2024)
Large-scale multi-center CT and MRI segmentation of pancreas with deep learning
Authors: Zheyuan Zhang, Elif Keles, Gorkem Durak, Yavuz Taktak, Onkar Susladkar, Vandan Gorade, Debesh Jha, Asli C Ormeci, Alpay Medetalibeyoglu, Lanhong Yao, Bin Wang, Ilkin Sevgi Isler, Linkai Peng, Hongyi Pan, Camila Lopes Vendrami, Amir Bourhani, Yury Velichko, Boqing Gong, Concetto Spampinato, Ayis Pyrros, Pallavi Tiwari, Derk C F Klatte, Megan Engels, Sanne Hoogenboom, Candice W Bolan, Emil Agarunov, Nassier Harfouch, Chenchan Huang, Marco J Bruno, Ivo Schoots, Rajesh N Keswani, Frank H Miller, Tamas Gonda, Cemal Yazici, Temel Tirkes, Baris Turkbey, Michael B Wallace, Ulas Bagci
Journal: Medical Image Analysis (2024)
Phase 2b randomized clinical trial of amlitelimab, an anti-OX40 ligand antibody, in patients with moderate-to-severe atopic dermatitis
Authors: Stephan Weidinger, Andrew Blauvelt, Kim A Papp, Adam Reich, Chih-Hung Lee, Margitta Worm, Charles Lynde, Yoko Kataoka, Peter Foley, Xiaodan Wei, Wanling Wong, Anne-Catherine Solente, Christine Weber, Samuel Adelman, Sonya Davey, Fabrice Hurbin, Natalie Rynkiewicz, Karl Yen, John T O'Malley, Charlotte Bernigaud
Journal: Journal of Allergy and Clinical Immunology (2024)

Amlitelimab, a fully human nondepleting mAb targeting OX40 ligand on antigen-presenting cells, could prevent T-cell-driven inflammation seen in atopic dermatitis (AD). This trial evaluated the efficacy and safety of amlitelimab in adults with AD. In this 2-part, phase 2b, randomized, double-blinded placebo-controlled trial (ClinicalTrials.gov identifier NCT05131477), patients received subcutaneous amlitelimab every 4 weeks at doses of 250 mg plus a 500-mg loading dose, 250 mg, 125 mg, or 62.5 mg or placebo for 24 weeks in Part 1 (1:1:1:1:1 randomization). In Part 2, clinical responders were reallocated 3:1 to stop taking amlitelimab or continue the previous dose regimen for 28 weeks. The primary end point was percentage of change in Eczema Area and Severity Index (EASI) from baseline to week 16. In all, 390 and 190 patients enrolled in Part 1 and Part 2, respectively. A significant percentage of change decrease in EASI was observed with amlitelimab doses versus with placebo (P < .001). Clinical responses at week 24 (Investigator Global Assessment 0/1 and/or a 75% reduction in EASI) were maintained at week 52 in patients continuing or stopping amlitelimab. Of the patients maintaining clinical response at week 52 after no longer receiving treatment, more than 80% had serum amlitelimab concentrations less than the 4-μg/mL threshold for several weeks before week 52. Reductions in AD-related biomarkers during Part 1 were maintained through Part 2. Amlitelimab was well tolerated over 52 weeks. Amlitelimab treatment significantly reduced clinical and biomarker responses, and was well tolerated in adults with AD through week 52. Sustained responses were observed in the majority of patients for 28 weeks after they had stopped taking amlitelimab.
When I use a word . . . Academic integrity—felonies and misdemeanours
Authors: Jeffrey K Aronson
Journal: BMJ (2024)

Academic norms include: preservation of academic autonomy; integrity in academic practices; a priori formulation of hypotheses and publication of protocols; the use of appropriate methods by which evidence is obtained; the use of appropriate methods for interpreting the accumulated knowledge so obtained; the need to take heed of the possible consequences, both intended and unintended, of research; the use of comprehensible language in describing outcomes and their interpretation; universalism; communality; disinterestedness; organised skepticism, but limited to one9s own sphere of academic interest; appropriate curiosity; avoidance of inappropriate enthusiasm; and respect for the work of others. Violation of all of these is possible, and different types of violations are known by different terms: "research misconduct" refers to three major violations, fabrication, falsification, and plagiarism; I prefer to call these collectively by the legal term "felonies," emphasising their gravity and importance. Other violations are known as "questionable research practices," which I prefer to call by the stronger term "misdemeanours," again emphasising their importance, although they are less grave than felonies. Interest in detecting, reporting, and discussing these violations has increased markedly since 1990, but I have found only two systematic reviews, one of which, disappointingly, but perhaps not unexpectedly, shows that there is little useful evidence on the subject, and a second, which shows that the likely prevalences of both types, felonies and misdemeanours, are higher than one would want, although probably estimated at lower than they truly are.
Multi-Modal Analysis of human Hepatic Stellate Cells identifies novel therapeutic targets for Metabolic Dysfunction-Associated Steatotic Liver Disease
Authors: Hyun Young Kim, Sara Brin Rosenthal, Xiao Liu, Charlene Miciano, Xiaomeng Hou, Michael Miller, Justin Buchanan, Olivier B. Poirion, Daisy Chilin-Fuentes, Cuijuan Han, Mojgan Housseini, Raquel Carvalho-Gontijo Weber, Sadatsugu Sakane, Wonseok Lee, Huayi Zhao, Karin Diggle, Sebastian Preissl, Christopher K. Glass, Bing Ren, Allen Wang, David A. Brenner, Tatiana Kisseleva
Journal: Journal of Hepatology (2024)

Metabolic dysfunction-associated steatotic liver disease (MASLD) ranges from Metabolic dysfunction-associated steatotic liver (MASL) to Metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis. Activation of Hepatic Stellate Cells (HSCs) into fibrogenic myofibroblasts plays a critical role in the pathogenesis of MASH liver fibrosis. We compared transcriptome and chromatin accessibility of human HSCs from NORMAL, MASL, and MASH livers at single cell resolution. We aimed to identify genes that are upregulated in activated HSCs and to determine which of these genes are key in the pathogenesis of MASH fibrosis.
The effect of methylation on the let-7-BCL2L1-BCL2 axis and the potential use of hypomethylating and BH3 mimetic drugs in histiocytic neoplasms
Authors: Mali Salmon-Divon, Refael Meyuchas, Ofer Shpilberg, Elimelech Okon, Jamal Benhamida, Mariko Yabe, Kseniya Petrova-Drus, Tal Zvida-Bloch, May Basood, Roei Mazor, Benjamin H. Durham, Julien Haroche, Omar Abdel-Wahab, Eli L. Diamond, Oshrat Hershkovitz-Rokah
Journal: Leukemia (2024)
Airway Disease Modeling with Gene-edited Human Basal Cell Transplantation
Authors: Andrew C. Berical, Hirofumi Kiyokawa, Mary Lou Beermann, Daniel Wallman, Gabrielle Cherfane, Victoria Dunphy, Jiehong Pan, Andrew Tilston-Lunel, Xaralabos Varelas, Amjad Horani, Steven L Brody, Darrell N Kotton, Finn J. Hawkins
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Airway Disease Modeling with Gene-edited Human Basal Cell Transplantation." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Humidified Noninvasive Ventilation versus High-Flow Therapy to Prevent Reintubation in Obese Patients: A Randomized Clinical Trial
Authors: Gonzalo Hernández, Jose Dianti, Irene Paredes, Francisco Moran, Margarita Marquez, Angel Calle, Laura Colinas, Gadea Alonso, Pilar Carneiro, Guillermo Morales, Fernando Suarez-Sipmann, Alfonso Canabal, Ewan Goligher, Oriol Roca
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

Rationale: The optimal strategy to prevent reintubation in patients with obesity remains uncertain. Objectives: We aimed to determine whether noninvasive ventilation (NIV) with active humidification is superior to a high-flow nasal cannula (HFNC) in preventing reintubation in patients with obesity at intermediate risk. Methods: We conducted a randomized controlled trial in two ICUs in Spain (June 2020-June 2021). We included patients ready for planned extubation with a body mass index >30 and three or fewer risk factors for reintubation. Patients with hypercapnia at the end of the spontaneous breathing trial were excluded. Patients were randomized to undergo NIV with active humidification or HFNC for 48 hours after extubation. The primary outcome was the reintubation rate within 7 days after extubation. As a secondary analysis, we performed a post hoc Bayesian analysis using three different priors. Measurements and Main Results: Of 144 patients (median age, 61 [25th-75th percentile range, 61-67] yr; 65 [45%] men), 72 received NIV and 72 received an HFNC. Reintubation was required in 17 (23.6%) patients receiving NIV and in 24 (33.3%) patients receiving HFNC (difference between groups, 9.7; 95% confidence interval, -4.9, 24.4). All of the secondary analysis showed nonsignificant differences. In the exploratory Bayesian analysis, the probability of a reduction in reintubation with NIV was 99% (data-driven prior), 90% (minimally informative prior), or 89% (skeptical prior). Conclusions: Among adult critically ill patients with obesity at intermediate risk for extubation failure, the rate of reintubation was not significantly lower with NIV than with HFNC. Nevertheless, there is a risk for underpowered results. Clinical trial registered with www.clinicaltrials.gov (NCT04125342).
ReNeu: A Pivotal, Phase IIb Trial of Mirdametinib in Adults and Children With Symptomatic Neurofibromatosis Type 1-Associated Plexiform Neurofibroma
Authors: Christopher L. Moertel, Angela C. Hirbe, Hans H. Shuhaiber, Kevin Bielamowicz, Alpa Sidhu, David Viskochil, Michael D. Weber, Armend Lokku, L. Mary Smith, Nicholas K. Foreman, Fouad M. Hajjar, Rene Y. McNall-Knapp, Lauren Weintraub, Reuben Antony, Andrea T. Franson, Julia Meade, David Schiff, Tobias Walbert, Prakash Ambady, Daniela A. Bota, Cynthia J. Campen, Gurcharanjeet Kaur, Laura J. Klesse, Stefania Maraka, Paul L. Moots, Kathryn Nevel, Miriam Bornhorst, Ana Aguilar-Bonilla, Sarah Chagnon, Nagma Dalvi, Punita Gupta, Ziad Khatib, Laura K. Metrock, P. Leia Nghiemphu, Ryan D. Roberts, Nathan J. Robison, Zsila Sadighi, Stacie Stapleton, Dusica Babovic-Vuksanovic, Timothy R. Gershon, Ahmed Raslan, Alpa Sidhu, Ana Aguilar-Bonilla, Andrea T. Franson, Andrew Walter, Angela C. Hirbe, Brian Van Tine, Carl Koschmann, Christopher L. Moertel, Cynthia Campen, Daniela A. Bota, David Schiff, David Viskochil, Dusica Babovic-Vuksanovic, Fouad M. Hajjar, Gurcharanjeet Kaur, Hans H. Shuhaiber, Jamie K. Capal, John Slopis, Jonathan Gill, Julia Meade, Kathryn Nevel, Laura K. Metrock, Kevin Bielamowicz, Laura J. Klesse, Lauren Weintraub, Leia Nghiemphu, Lindsay Kilburn, Maciej M. Mrugala, Mary Lou Schmidt, Miriam Bornhorst, Nagma Dalvi, Nathan J. Robison, Nick K. Foreman, Paul L. Moots, Prakash Ambady, Punita Gupta, Radhika Dhamija, Rene Y. McNall-Knapp, Rueben Antony, Ryan D. Roberts, Ryan Merrell, Sarah Chagnon, Stacie Stapleton, Stefania Maraka, Timothy R. Gershon, Tobias Walbert, Ziad Khatib, Zsila Sadighi
Journal: Journal of Clinical Oncology (2024)

Pharmacologic therapies for neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PNs) are limited; currently, none are US Food and Drug Administration-approved for adults.
Booster vaccination normalizes postvaccination immunity in patients with severe asthma
Authors: Hitasha Rupani, Rekha Chaudhuri, David J. Jackson, Helen Moyses, Ramesh J. Kurukulaaratchy, Hans Michael Haitchi, Michael R. Edwards, Sebastian L. Johnston, Ratko Djukanovic
Journal: Journal of Allergy and Clinical Immunology (2024)
Unsupervised Classification of the Host Response Identifies Dominant Pathobiological Signatures of Sepsis in Sub-Saharan Africa
Authors: Matthew J Cummings, Julius J Lutwama, Nicholas Owor, Alin S. Tomoiaga, Jesse E. Ross, Moses Muwanga, Christopher Nsereko, Irene Nayiga, Stephen Kyebambe, Joseph Shinyale, Thomas Ochar, Moses Kiwubeyi, Rittah Nankwanga, Kai Nie, Hui Xie, Sam Miake-Lye, Bryan Villagomez, Jingjing Qi, Steven J. Reynolds, Martina Cathy Nakibuuka, Xuan Lu, John Kayiwa, Mercy Haumba, Joweria Nakaseegu, Xiaoyu Che, Misaki Wayengera, Sankar Ghosh, Seunghee Kim-Schulze, W. Ian Lipkin, Barnabas Bakamutumaho, Max R O'Donnell
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

The global burden of sepsis is concentrated in sub-Saharan Africa, where inciting pathogens are diverse and HIV co-infection is a major driver of poor outcomes. Biological heterogeneity inherent to sepsis in this setting is poorly defined.
Reply to the Letter to the Editor regarding ‘PFS, OS or toxicity: what is the most important factor in the treatment of EGFR-mutated lung cancer?’ by T. Nishimura and H. Fujimoto
Authors: E. Felip, B.C. Cho, D. Nguyen, J.C. Curtin, S. Sethi, J.M. Bauml, S.-H. Lee
Journal: Annals of Oncology (2024)
The Bayesian Phylogenetic Bootstrap, Application to Short Trees and Branches
Authors: Frédéric Lemoine, Olivier Gascuel
Journal: Molecular Biology and Evolution (2024)

Abstract Felsenstein's bootstrap is the most commonly used method to measure branch support in phylogenetics. Current sequencing technologies can result in massive sampling of taxa (e.g. SARS-CoV-2). In this case, the sequences are very similar, the trees are short, and the branches correspond to a small number of mutations (possibly 0). Nevertheless, these trees contain a strong signal, with unresolved parts but a low rate of false branches. With such data, Felsenstein's bootstrap is not satisfactory. Due to the frequentist nature of bootstrap sampling, the expected support of a branch corresponding to a single mutation is ∼63%, even though it is highly likely to be correct. Here, we propose a Bayesian version of the phylogenetic bootstrap in which sites are assigned uninformative prior probabilities. The branch support can then be interpreted as a posterior probability. We do not view the alignment as a small subsample of a large sample of sites, but rather as containing all available information (e.g. as with complete viral genomes, which are becoming routine). We give formulas for expected supports under the assumption of perfect phylogeny, in both the frequentist and Bayesian frameworks, where a branch corresponding to a single mutation now has an expected support of ∼90%. Simulations show that these theoretical results are robust to realistic data. Analyses on low-homoplasy viral and nonviral datasets show that Bayesian bootstrap support is easier to interpret, with high supports for branches very likely to be correct. As homoplasy increases, the two supports become closer and strongly correlated.
Organophosphorus Flame Retardants and Metabolic Disruption: An <i>in Silico</i> , <i>in Vitro</i> , and <i>in Vivo</i> Study Focusing on Adiponectin Receptors
Authors: Ying Liu, Xiaochun Ma, Yifei Le, Jiafan Feng, Mengting Xu, Wanyue Wang, Cui Wang
Journal: Environmental Health Perspectives (2024)

Environmental chemical exposures have been associated with metabolic outcomes, and typically, their binding to nuclear hormone receptors is considered the molecular initiating event (MIE) for a number of outcomes. However, more studies are needed to understand the influence of such exposures on cell membrane-bound adiponectin receptors (AdipoRs), which are critical metabolic regulators.
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis
Authors: Yingjun Zhao, I-Chu Tseng, Charles J. Heyser, Edward Rockenstein, Michael Mante, Anthony Adame, Qiuyang Zheng, Timothy Huang, Xin Wang, Pharhad E. Arslan, Paramita Chakrabarty, Chengbiao Wu, Guojun Bu, William C. Mobley, Yun-wu Zhang, Peter St. George-Hyslop, Eliezer Masliah, Paul Fraser, Huaxi Xu
Journal: Neuron (2024)
Glioma–Astrocyte connexin43 confers temozolomide resistance through activation of the E2F1/ERCC1 axis
Authors: Yanping Gui, Hongkun Qin, Xinyu Zhang, Qianqian Chen, Fangyu Ye, Geng Tian, Shihe Yang, Yuting Ye, Di Pan, Jieying Zhou, Xiangshan Fan, Yajing Wang, Li Zhao
Journal: Neuro-Oncology (2024)

Glioma is the most prevalent and lethal tumor of the central nervous system. Routine treatment with Temozolomide (TMZ) would unfortunately result in inevitable recurrence and therapy resistance, severely limiting therapeutic efficacy. Tumor associated astrocytes (TAAs) are key components of the tumor microenvironment and increasing evidence has demonstrated that aberrant expression of Connexin43 (Cx43) was closely associated with glioma progression and TMZ resistance. However, the specific role of Cx43 in mediating TMZ resistance through glioma and astrocyte interactions has not been fully explored.