tbuckley/cabot-search huggingface dataset:
Capillary sampling is routine in Germany
Authors: A Bernhardt
Journal: BMJ (1995)

modest alkalosis causing vasoconstriction (pH about 7 4-7 5) this difference increased to 0 53 kPa (unpublished observations).Forster et al have found unsatisfactory correlation between arterial and arterialised venous samples for partial pressure of oxygen.4Capillary or venous sampling to estimate arterial blood gas pressure has been used for many years,24 and several other indirect methods have also been used.'Whilesome results have been encouraging, the conclusion that such methods should become routine is probably still premature.If knowledge of the arterial blood gas pressures is important in determining management in potentially life threatening conditions then the arterial blood gas pressures should be measured.
Endoscopic Fibrin Sealing in Gastroduodenal Ulcer Hemorrhage
Authors: G. Herold, G. Preclik, E. F. Stange
Journal: Endoscopy (1995)

Patients with bleeding upper gastrointestinal ulcers were observed during the period 1989–1991. The clinical outcome was examined by retrospective analysis. Of all patients with benign gastric or duodenal ulcers, 85 patients presented with stigmata of bleeding, e.g., Forrest grades Ia-IIb. This group was treated endoscopically by the injection of fibrin sealant with or without additional hypertonic saline plus epinephrine. Endoscopic therapeutic procedures were repeated until the ulcers reached Forrest grade III. While initial hemostasis was achieved in all patients, permanent hemostasis declined to 85.9% in our series. The overall bleeding-associated mortality was 7.0%, and in 9.4% continuous bleeding required surgery. No therapy-associated complications were seen. Interestingly, fibrin glue f to induce a rapid healing process. It may be concluded that fibrin sealing is a complication-free highly effective endoscopic therapy.
Abstract 4535: Therapeutic Angiogenesis by Mononuclear Cell Implantation for Critical Digit Ischemia of Patients with Connective Tissue Diseases
Authors: Masafumi Takahashi, Yoshiaki Ishigatsubo, Kazuteru Fujimoto, Masaaki Miyamoto, Seiji Minota, Takashi Horie, Yoshifusa Aizawa, Jun Amano, Toyoaki Murohara, Hiroaki Matsubara, Uichi Ikeda
Journal: Circulation (2008)

Systemic sclerosis (SSc or scleroderma) is an autoimmune connective tissue disease characterized by diffuse fibrosis, degenerative changes, and microvascular abnormalities. The vasculopathy mainly affects small arteries and capillaries and causes insufficient blood flow, which leads to clinical manifestations, such as Raynaud’s syndrome, fingertip ulcers, and gangrene. Recently, implantation of bone marrow-derived mononuclear cells (MNCs) has been successfully used for therapeutic neovascularization in Buerger’s disease that is thought to be an “autoimmune” vasculitis. The purpose of this study is to determine the efficacy of autologous MNC implantation into the ischemic digits of patients with connective tissue diseases. This study was performed as a prospective, non-randamized, and multicenter clinical trial. Thirty-four patients (19 SSc, 5 SLE, 2 CREST, 2 MCTD, 4 APS, 2 PN) who had painful ischemic digits with skin ulcers were enrolled in this study. Autologous MNCs obtained from bone marrow or peripheral blood were implanted into the ischemic digits. Ischemic pain and ulcers improved remarkably after MNC implantation. In particular, SSc patients showed dramatic improvement of these parameters (18 of 19 patients, 94.7%). In patients with other types of connective tissue diseases, pain and ulcers improved in 12 of 15 patients (80.0%). No serious adverse event was observed. These results demonstrate that implantation of autologous MNCs from bone marrow or peripheral blood into ischemic digits is feasible, safe and effective for improvement of pain and skin ulcers in patients with connective tissue diseases including SSc. Thus, larger, randomized and controlled trials for this cell therapy in patients with connective tissue diseases will be warranted.
Abstract 1869: Effect of Nebivolol vs. Metoprolol on Endothelial Function, Endothelial Progenitor Cell Mobilization and Left Ventricular Remodeling and Dysfunction Early After Myocardial Infarction
Authors: Sajoscha A Sorrentino, Carola Doerries, Wazma Mohmand, Razma Akbar, Christian Besler, Arnd Schaefer, Helmut Drexler, Ulf Landmesser
Journal: Circulation (2006)
Abstract 9588: Low Flow, Low Gradient and Severe Aortic Stenosis in Patients with Preserved Ejection Fraction: Is There a Role for Hemodynamic Catheterization?
Authors: Jonathon Adams, Suresh Challa, Mohammad Najib, Verghese Mathew, Charanjit Rihal, Hari Chaliki
Journal: Circulation (2011)

Introduction- Recent studies based on echocardiographic data have described an entity termed paradoxical low-flow, low-gradient severe aortic stenosis (AS) with preserved ejection fraction (EF). It is not clear whether this condition is also seen in patients who undergo hemodynamic catheterization. Objective- To determine the prevalence of low-flow in patients with low mean gradient (MG) severe AS despite preserved EF as determined by echocardiography who subsequently undergo hemodynamic catheterization. Methods- We retrospectively reviewed medical records of 259 patients who underwent hemodynamic catheterization at Mayo Clinic from 2000-2009 to assess the severity of AS within 6 months of their echocardiographic study. Results- A total of 35 patients (mean age 75±9yrs; 49% males) had MG (≤ 40 mm Hg) and aortic valve area (AVA ≤ 1 cm2) despite preserved EF (≥50%) as determined by echocardiography. A total of 7/35 patients (20%) had low flow by echocardiography, defined as stroke volume index (SVI) ≤ 35 ml/m2 (median SVI of 32 ml/m2, inter-quartile range 30-33 ml/m2). Among the same 35 patients, there were 23 patients who had both low MG (≤ 40 mm Hg) and severe AS (AVA ≤ 1 cm2), while a total of 14/35 patients (40%) had low MG, severe AS as well as low flow (median SVI of 32 ml/m2, inter-quartile range 29-33 ml/m2) as determined by hemodynamic catheterization. A statistically significant correlation with modest association was observed between invasive and noninvasive measurements of MG, SVI, and AVA (r=0.48 ; p = 0.003; r=0.48; p = 0.004 ; r=0.36; p=0.03 respectively) in our study group of 35 patients. In most patients (94%) MG by catheterization was also ≤ 40 mm Hg. However, agreement between echocardiography and catheterization to identify patients with paradoxical low-flow, low MG, severe AS was poor (kappa = 0.03). Conclusions- 1) Paradoxical low flow, low-gradient severe aortic stenosis is also observed in patients who undergo hemodynamic catheterization. 2) Further studies are needed to better understand the pathophysiology, best method for diagnosis and true prevalence of this entity.
Abstract 8609: Long-Term Outcomes of Surgical Treatment for Atrial Fibrillation in a Complex Population
Authors: David A Cesario, Mark Cunningham, Craig Baker, Robbin Cohen, Becky Lopez, Vaughn Starnes
Journal: Circulation (2011)

Objective: Surgical procedures are increasingly used to treat patients with long-standing persistent atrial fibrillation (AF). We sought to evaluate the safety and efficacy of various surgical approaches to AF at a high-volume tertiary surgical referral center. Methods: In this retrospective, single center study, we analyze our experience with the surgical treatment of AF. We evaluated 272 consecutive patients operated on, over a 9 year period. The surgical procedure for AF performed on each patient varied and was left up to the discretion of the surgeon with 29.8%(n=80) of patients receiving a complete right and left-sided Maze procedure including pulmonary vein isolation, 20.5%(n=55) of patients receiving a left-sided Maze procedure including pulmonary vein isolation, 4.9%(n=13) of patients receiving a right-sided Maze procedure including pulmonary vein isolation and 44.8%(n=120) of patients receiving pulmonary vein isolation alone. The vast majority of patients underwent at least one concomitant surgical procedure (93.7% AF surgery + concomitant surgical procedure, 6.3% stand-alone Maze). Patients were followed for a mean period of 42.3 months (+/-27 months). Cardiac rhythm was analyzed at discharge, 1-year follow-up visit and then re-analyzed on an annual basis. Results: In total 265 patients were analyzed, 4 patients were lost to follow-up and 3 expired prior to one year follow-up. Survival rates at 1-year were 96.5%. 50.2% of our patients were discharged in sinus rhythm. Additionally, 12.7% of patients received a new permanent pacemaker prior to their initial hospital discharge. At the 1-year follow-up visit 77% of patients were found to be in sinus rhythm or atrial paced rhythm and 23 % of patients were in AF/flutter. Our most recent analysis revealed 71.8 % of patients remain in sinus rhythm or atrial paced rhythm at up to 9 years post-surgical intervention. Conclusions: Surgical procedures for AF resulted in 1-year maintenance of sinus rhythm rates of 77%. These success rates appear largely maintained over a follow-up period of up to 9 years. Our patients were taken from a complex surgical population at a busy academic surgical center. We believe these numbers reflect real-world success rates in this patient population.
Abstract 11018: Age-related Prognosis of Syncope Associated With a Preexcitation Syndrome
Authors: Beatrice Brembilla-Perrot, Anne Moulin Zinsh, Jean Marc Sellal, Pierre Yves Zinzius, Jerome Schwartz, Maheshwar Pauriah, Gabriel Cismaru, Christian De Chillou, Daniel Beurrier, Etienne Aliot, FranCois MarCon
Journal: Circulation (2012)

Background: Vagal-related syncope represents the most frequent cause of syncope in population Syncope in Wolff-Parkinson-White syndrome (WPW) can be without relationships with WPW, but also may rev...
Abstract 11619: Control of Cardiac Hypertrophy and Fibrosis by the Notch Pathway
Authors: Mohamed Nemir, Melanie Metrich, Isabelle Plaisance, Mario Lepore, Corinne Berthonneche, Alexandre Sarre, Freddy Radtke, Thierry Pedrazzini
Journal: Circulation (2011)

The Notch pathway is a cellular communication system, which is mediated by transmembrane receptors and ligands expressed on adjacent cells. We demonstrated previously the importance of Notch1 (rece...
Abstract 2646: Intravascular Ultrasound Evaluation of Optimal Drug-eluting Stent Expansion after Post-stent Balloon Dilation Using Non-compliant Balloon versus Semi-compliant Balloon. Post-stent Optimal Stent Expansion Trial (POET).
Authors: Young-Guk Ko, Jae-Youn Moon, Donghoon Choi, Yangsoo Jang, Woong Chol Kang, Taehoon Ahn, Byoung-Keuk Kim, Seong Jin Oh, Dong Woon Jeon, Joo-Young Yang
Journal: Circulation (2006)
Family Rituals and the Recurrence of Alcoholism Over Generations
Authors: Steven J. Wolin, Linda A. Bennett, Denise L. Noonan
Journal: American Journal of Psychiatry (1979)

There have been relatively few attempts to identify environmental factors in the transmission of alcoholism across generations. Using the framework of family systems theory, the authors examined the extent of change in family rituals in 25 families in which at least 1 parent was or had been an alcoholic. They found that families whose rituals were altered during the period of heaviest parental drinking were more likely to evidence transmission of an alcohol problem to the children's generation than families whose rituals remained intact.
Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers
Authors: A Breier, A K Malhotra, D A Pinals, N I Weisenfeld, D Pickar
Journal: American Journal of Psychiatry (1997)

Agents that antagonize the N-methyl-D-aspartic acid (NMDA) receptor, such as phencyclidine and ketamine, produce an acute psychotic state in normal individuals that resembles some symptoms of schizophrenia. The aim of this study was to determine which brain regions are involved in NMDA receptor-mediated psychosis.Positron emission tomography with [18F]fluorodeoxyglucose was used to determine cerebral metabolic activity in 17 healthy volunteers while an acute psychotic state was induced simultaneously by the administration of subanesthetic doses of ketamine.Ketamine produced focal increases in metabolic activity in the prefrontal cortex and an acute psychotic state. A change in one psychotic symptom, conceptual disorganization, was significantly related to prefrontal activation.These data suggest that the prefrontal cortex may be involved in mediating NMDA receptor-induced psychosis.
Abstract 2527: Impairment Of Insulin-stimulated Vasodilation In Patients With Metabolic Syndrome
Authors: Francesca Schinzari, Manfredi Tesauro, Valentina Rovella, Nadia Mores, Domenico Melina, Carmine Cardillo
Journal: Circulation (2007)

Defective vasorelaxation is one of the earliest abnormalities in the atherosclerotic process. Insulin has previously been shown to enhance endothelium-dependent vasodilator responsiveness, therefor...
Abstract 1107: Risk Factors Predicting Intra and Postoperative Cardiac Arrest or Myocardial Infarction in Surgical Patients
Authors: Himani Gupta, Prateek K Gupta, Manu Kaushik, Weldon J Miller, Claire Hunter, Dennis J Esterbrooks
Journal: Circulation (2009)

Objective: To identify factors associated with intra and postoperative myocardial infarction or cardiac arrest (MICA) within 30 days of surgery. Methods: Multivariate logistic regression of the Ame...
Abstract P167: Effectiveness of an "AED Map on a Mobile Web" System: A Randomized Controlled Trial
Authors: Tomohiko Sakai, Taku Iwami, Kentaro Kajino, Tetsuhisa Kitamura, Chika Nishiyama, Hiroshi Tanaka, Seishiro Marukawa, Takashi Kawamura, Taro Irisawa, Osamu Tasaki, Tadahiko Shiozaki, Hiroshi Ogura, Yasuyuki Kuwagata
Journal: Circulation (2009)

Backgrounds: Although early defibrillation by the public access defibrillation is the key strategy to save out-of-hospital cardiac arrest victims, it is difficult to immediately find out an AED in ...
BAY 43–9006 (sorafenib-BAY) alters proliferation pathways and mutant specific-PCR (MS-PCR) improves detection of BRAF mutations in metastatic melanoma (MM)
Authors: A. C. Pavlick, L. Liebes, P. Brooks, J. Yoon, A. Hamilton, H. Yee, D. Polsky, M. Buckley, J. Wright, I. Osman
Journal: Journal of Clinical Oncology (2007)

8542 Background: Approximately 60% of melanomas carry BRAF mutations (mut). BAY is a multi-kinase inhibitor that inhibits the BRAF pathway. A phase II trial of BAY in MM is being conducted to: 1) determine if treatment (tx) with BAY can alter proliferation as measured by cyclin D1, Ki-67 and ERK, 2) assess for differential anti-tumor responses and 3) to assess a newly developed fluorescent-based PCR assay to detect mutant BRAF. Methods: Eligibility criteria: Biopsy (bx)-accessible, untreated MM. Measurable disease (RECIST). Stratification of tumor BRAF status determined by routine PCR sequencing for codon 600 mut prior to tx and fluorescent MS-PCR sequencing for confirmation. MS-PCR specifically amplified the M-BRAF allele without amplifying the wild-type (WT)allele. Tx: BAY 400 mg po BID D1–28 q4w. Repeat bx on Day 28. Bx assessed for Ki-67, cyclin-D1 and ERK. Serum collagen cryptic epitopes were measured serially. Re-imaging was done every 2 cycles and pts treated until POD. Results: 29 pts (9-M1a, 8-M1b, 12-M1c) enrolled. 26 wild type (WT) and 3 mutant (M) BRAF by routine PCR. Due to the low yield of mut on routine PCR, MS-PCR was done. 6 mutants were detected in the first 16 pts with MS-PCR compared to 2 with routine sequencing. Median age: 68 (range 22–91). 8 pts with LDH ≥ 1.5 × nl. Tox: Gr I-diarrhea(7), alopecia(4), rash(6), mucositis(4), nausea(4), pain(4), hand-foot(2); Gr II- HTN(4), fatigue(2),mucositis(1), rash(3), pain(3), hand-foot(2); Gr III-hand-foot(1), rash(1), fatigue(1) and intestinal perforation(1). Responses: 12 NE (2 WD, 8 early POD, 1 tox, 1 too early); M BRAF- 1 PR (lymph nodes and large SQ arm masses) and 2 PD; WT BRAF- 1 PR, 7 POD after 2 cycles, 6 SD. Matched paired biopsies demonstrated down regulation of tumor ki-67, erk and cyclin-D1. Collagen cryptic epitopes correlated with tumor responses. Conclusions: MM patients with tumors that were molecularly characterized for BRAF mutational status were entered on this single agent BAY trial and responses were seen in both M and WT arms. Down-regulation of Ki-67, cyclin D1 and ERK was demonstrated and MS-PCR improved the sensitivity to detect BRAF mut. Supported by NCI N01-CM17103 and TRI. No significant financial relationships to disclose.
Abstract 18193: Distinct Effects of Unfractionated Heparin and Bivalirudin on Circulating Pro-Angiogenic Peptides
Authors: Navin K Kapur, Iris Z Jaffe, Adil A Yunis, Najwa N Mohammad, Mark Aronovitz, Heather Nickerson, Andrew Weintraub, Carey D Kimmelstiel, Ameer Shah, Michelle Esposito, Richard H Karas, Michael E Mendelsohn
Journal: Circulation (2010)

Unfractionated heparin (UFH) and bivalirudin (Bival) are commonly employed anticoagulants during percutaneous coronary intervention (PCI). Soluble fms-like tyrosine kinase 1 (sFLT1) is a circulatin...
Effective Treatment Of Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma With Autologous T Cells Genetically-Engineered To Express An Anti-CD19 Chimeric Antigen Receptor
Authors: James N. Kochenderfer, Mark E. Dudley, Sadik H. Kassim, Robert O. Carpenter, James C. Yang, Giao Q. Phan, Marybeth S. Hughes, Richard M. Sherry, Steven Feldman, David Spaner, Debbie-Ann N. Nathan, Kathleen E. Morton, Mary Ann Toomey, Steven A. Rosenberg
Journal: Blood (2013)
Next: Text
Authors: James S. Kahn
Journal: JAMA (2012)

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Abstract 18238: Transition from Vitamin-K-antagonists to New Oral Anticoagulants in Daily Care - First Results of the Prospective NOAC Registry (NCT 01588119)
Authors: Christina Koehler, Sebastian Werth, Vera Gelbricht, Ulrike Hansel, Luise Tittl, Ines Beyer-Westendorf, Thomas Schreier, Jan Beyer-Westendorf
Journal: Circulation (2012)

Background:  New oral anticoagulants (NOAC) have been approved in a number of countries for long-term anticoagulation in atrial fibrillation (AF) and venous thromboembolism (VTE). Currently, many patients are switched from Vitamin-K antagonists (VKA) to NOAC. We evaluated the transition process (time gap between last intake of VKA, last INR sampling and first intake of NOAC) in unselected patients from daily care.    Patients and methods:   A network of 115 physicians from private practice and hospitals enrol patients in the NOAC registry. Inclusion criteria are: 1) indication for NOAC anticoagulation >3 month; 2) age > 18 years; 3) written informed consent; 4) availability for follow-up. No Exclusion criteria apply. Patients are prospectively followed by phone visits at day 30 day and quarterly thereafter to collect efficacy and safety data.   Results:  Until June 6 th  2012, 683 patients were registered. Of the 266 patients switched from VKA, data on the transition process were available in 213 patients (70.0% AF, 30.0% VTE). Of these, only 104 patients (48.8%) had a recorded INR measurement at the end or within 7 days before the end of VKA treatment (mean INR 2.4 for all, 2.6 in AF and 2.1 in VTE patients; table 1). In patients with INR tests, time between last INR and start of NOAC was around 3 days (5 days in AF and 2 days in VTE patients). For all patients, time between last VKA and start NOAC was around 7 days (8 days in AF; 4 days in VTE patients).   Conclusion:  In unselected patients in daily care, only 50% of patients have a documented INR test before NOAC is started. Despite documented INR values in the lower therapeutic range, physicians are reluctant to start NOAC therapy immediately and allow for another 2 to 5 days before NOAC is started. However, no major vascular events or major bleedings were observed in VKA transition patients at day 30, indicating that this procedure is safe.
Abstract 4512: One-Year Clinical Outcome after Percutaneous Aortic Valve Implantation
Authors: Peter P de Jaegere, Jan Kovac, Amber M Otten, Tom Sybt, Lucas van Dijk, Nick Piazza, Johan Bence, Arie P Kappetein, Derek Chin, Francisco J Orellana, Ad J Bogers, Elaine Logtens, Frans Oei, Charles Kik, Ron van Domburg, Patrick W Serruys
Journal: Circulation (2008)

Percutaneous Aortic Valve Replacement (PAVR) is increasingly being used to treat patients with aortic stenosis who are considered poor surgical candidates. Thirty-day mortality has been reported to vary between 12 and 20%. One study reported a one-year mortality of 18%. We sought to determine the one-year clinical outcome in the patients treated in two institutions by means of a prospective observational cohort study. Between November 2005 and May 2008, 81 patients with aortic stenosis and high surgical risk were treated with the CoreValve Revalving System. Predefined demographic, clinical, laboratory, echo and procedural variables were prospectively entered into a dedicated database. Prospective follow-up data were collected during out-patient clinic visits. Vital status was obtained by contacting the civil registries. Follow-up was complete for all patients. Mean ± SD age was 83 ± 6 years and 46 % were male. The mean logistic EuroSCORE was 17 ± 10. The baseline LV ejection fraction was 45 ± 13. Peak velocity (Mean ± SD) was 4.3 ± 0.8 m/sec pre-PAVR and was 2.0 ± 0.5 immediately post-PAVR. At 30 days, 4 patients (5%) died (cardiac tamponade during PAVR: 2 patients, sepsis 4 weeks after PAVR: 1 patient, subdural haematoma after an ill-fated fall during cardiac rehabilitation: 1 patient). PAVR was complicated by a stroke in 4 patients (5%) and by a myocardial infarction in 2 other patients (2%). The one-year mortality rate was 15%. In the present series of elderly patients treated with PAVR because of severe aortic stenosis, the 30-day mortality was only 3,8%. It was 15% at one year. In all patients, mortality was due to associated cardio-vascular disease. Clinically, there was no evidence of valve dysfunction.