tbuckley/cabot-search huggingface dataset:
Transsynaptic labeling and transcriptional control of zebrafish neural circuits
Authors: Cagney E. Coomer, Daria Naumova, Mustafa Talay, Bence Zolyomi, Nathaniel J. Snell, Altar Sorkaç, Jean Michel Chanchu, Ji Cheng, Ivana Roman, Jennifer Li, Drew Robson, David L. McLean, Gilad Barnea, Marnie E. Halpern
Journal: Nature Neuroscience (2024)
Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells
Authors: Zhen Zhang, Marlene Langenbach, Sagar Sagar, Viktor Fetsch, Jonas Stritzker, Elizabeth Severa, Ke Meng, Frances Winkler, Nisha Rana, Katharina Zoldan, Ira Godbole, Sabrina Solis, Jeffrey S. Weber, David Rafei-Shamsabadi, Saskia Lehr, Rebecca Diehl, Ana Cecilia Venhoff, Reinhard E. Voll, Nico Buettner, Christoph Neumann-Haefelin, Tobias Boettler, Maike Hofmann, Melanie Boerries, Frank Meiss, Robert Zeiser, Robert Thimme, Ramin S. Herati, Bertram Bengsch
Journal: Nature Immunology (2024)
The association between adverse childhood experiences and adult cardiac function in the UK Biobank
Authors: Juan C Quiroz, Jackie Cooper, Celeste McCracken, Mohammed Y Khanji, Liliana Laranjo, Nay Aung, Aaron Mark Lee, Judit Simon, Theodore Murphy, Luca Biasiolli, Stefan K Piechnik, Pal Maurovich-Horvat, Steffen E Petersen, Zahra Raisi-Estabragh
Journal:  (2024)

Abstract Aims The importance of early life factors in determining health in later adulthood is increasingly recognized. This study evaluated the association of adverse childhood experiences (ACEs) with cardiovascular magnetic resonance (CMR) phenotypes. Methods and results UK Biobank participants who had completed CMR and the self-reported questionnaire on traumatic childhood experiences were included. Images were analysed using automated pipelines to extract measures of left and right ventricular (LV and RV) structure and function, myocardial character, and arterial compliance. Multivariable linear regression was used to estimate the association of childhood adversity with CMR phenotypes adjusting for age, sex, deprivation, education, obesity, smoking, alcohol intake, exercise level, diabetes, hypertension, and hypercholesterolaemia. Amongst 30 814 participants analysed, 6023 (19.5%) experienced physical abuse, 2746 (8.9%) sexual abuse, 4685 (15.2%) emotional abuse, 6822 (22.1%) emotional neglect, and 4534 (14.7%) physical neglect. Except for physical abuse, women reported greater rates of childhood adversity than men. Collectively, all types of childhood adversity were associated with smaller LV and RV volumes, greater LV mass, a concentric pattern of LV remodelling, poorer LV and RV function, lower aortic compliance, and greater arterial stiffness. Sexual abuse was associated with unhealthy CMR phenotypes in age- and sex-adjusted models, but these relationships were attenuated in fully adjusted models. Physical neglect had the most prominent pattern of adverse cardiovascular remodelling. Conclusion ACEs were associated with unhealthy cardiovascular remodelling in adulthood, independent of traditional cardiovascular risk factors. These findings support the consideration of early life factors in cardiovascular disease risk assessment.
Effectiveness of Interventions to Reduce Opioid Use After Orthopaedic Surgery: A Systematic Review of Randomised Controlled Trials
Authors: Melanie Hamilton, Stephanie Mathieson, Masoud Jamshidi, Andy Wang, Yi-Ching Lee, Danijela Gnjidic, Chung-Wei Christine Lin
Journal: Drugs (2024)

The prescribing of opioids to patients for postoperative pain can lead to persistent opioid use. This review investigated the effectiveness of interventions aimed at reducing opioid use in patients after orthopaedic surgery. Electronic databases were searched from inception to November 2023. We included randomised controlled trials investigating interventions aimed at reducing opioid use after orthopaedic surgery. Two reviewers conducted the screening and data extraction and assessed the risk of bias (Cochrane Risk of Bias tool) and certainty of evidence (GRADE). The primary outcome was the mean daily dose of opioid analgesic medications in the medium term (1–3 months after randomisation). Results were pooled in a meta-analysis using a random-effects model where appropriate (e.g. I2 < 50%) or summarised narratively. The search yielded 17,471 records, of which 39 trials were included. High heterogeneity meant that most comparisons could not be pooled. The mean daily dose was lower with multimodal analgesia interventions than with placebo/no intervention/usual care or active control in the medium term. No between-group differences were found between other pharmacological or non-pharmacological interventions and either placebo/no intervention/usual care or active control at the medium-term time point. The certainty of evidence ranged from low to moderate. Multimodal analgesic interventions may reduce opioid use compared with placebo/no intervention/usual care or active control in the medium term. However, the high heterogeneity and low certainty of evidence means it is uncertain which interventions are effective in reducing opioid use after orthopaedic surgery.
Aligning Large Language Models with Humans: A Comprehensive Survey of ChatGPT’s Aptitude in Pharmacology
Authors: Yingbo Zhang, Shumin Ren, Jiao Wang, Junyu Lu, Cong Wu, Mengqiao He, Xingyun Liu, Rongrong Wu, Jing Zhao, Chaoying Zhan, Dan Du, Zhajun Zhan, Rajeev K. Singla, Bairong Shen
Journal: Drugs (2024)

Due to the lack of a comprehensive pharmacology test set, evaluating the potential and value of large language models (LLMs) in pharmacology is complex and challenging. This study aims to provide a test set reference for assessing the application potential of both general-purpose and specialized LLMs in pharmacology. We constructed a pharmacology test set consisting of three tasks: drug information retrieval, lead compound structure optimization, and research trend summarization and analysis. Subsequently, we compared the performance of general-purpose LLMs GPT-3.5 and GPT-4 on this test set. The results indicate that GPT-3.5 and GPT-4 can better understand instructions for information retrieval, scheme optimization, and trend summarization in pharmacology, showing significant potential in basic pharmacology tasks, especially in areas such as drug pharmacological properties, pharmacokinetics, mode of action, and toxicity prediction. These general LLMs also effectively summarize the current challenges and future trends in this field, proving their valuable resource for interdisciplinary pharmacology researchers. However, the limitations of ChatGPT become evident when handling tasks such as drug identification queries, drug interaction information retrieval, and drug structure simulation optimization. It struggles to provide accurate interaction information for individual or specific drugs and cannot optimize specific drugs. This lack of depth in knowledge integration and analysis limits its application in scientific research and clinical exploration. Therefore, exploring retrieval-augmented generation (RAG) or integrating proprietary knowledge bases and knowledge graphs into pharmacology-oriented ChatGPT systems would yield favorable results. This integration will further optimize the potential of LLMs in pharmacology.
Food Allergy Genetics and Epigenetics: A Review of Genome‐Wide Association Studies
Authors: Aleix Arnau‐Soler, Bénédicte L. Tremblay, Yidan Sun, Anne‐Marie Madore, Mathieu Simard, Elin T. G. Kersten, Ahla Ghauri, Ingo Marenholz, Thomas Eiwegger, Elinor Simons, Edmond S. Chan, Kari Nadeau, Vanitha Sampath, Bruce D. Mazer, Susan Elliott, Christine Hampson, Lianne Soller, Andrew Sandford, Philippe Begin, Jennie Hui, Bethany F. Wilken, Jennifer Gerdts, Adrienn Bourkas, Anne K. Ellis, Denitsa Vasileva, Ann Clarke, Aida Eslami, Moshe Ben‐Shoshan, David Martino, Denise Daley, Gerard H. Koppelman, Catherine Laprise, Young‐Ae Lee, Yuka Asai
Journal: Allergy (2024)

In this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allergy, as well as a discussion of advantages and limitations of the different types of studies in genetic research. We specifically focus on the results of genome-wide association studies in food allergy, which have identified 16 genetic variants that reach genome-wide significance, many of which overlap with other allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis. Identified genes for food allergy are mainly involved in epithelial barrier function (e.g., FLG, SERPINB7) and immune function (e.g., HLA, IL4). Epigenome-wide significant findings at 32 loci are also summarized as well as 14 additional loci with significance at a false discovery of < 1 × 10
Occurrence, mortality, and economic burden of brain disorders in Denmark, 2015–2021: a population-based cohort study
Authors: Cecilia Hvitfeldt Fuglsang, Thomas Bøjer Rasmussen, Jan Håkon Rudolfsen, Jens Olsen, Niels Skipper, Sinna Pilgaard Ulrichsen, Henrik Toft Sørensen, Christian Fynbo Christiansen
Journal: The Lancet Regional Health - Europe (2024)
Deep-Insights: Nanoengineered Gel-Based Localized Drug Delivery for Arthritis Management
Authors: Anitha Sriram, Harshada Ithape, Pankaj Kumar Singh
Journal: Asian Journal of Pharmaceutical Sciences (2024)

Arthritis is an inflammatory joint disorder that progressively impairs function and diminishes quality of life. Conventional therapies often prove ineffective, as oral administration lacks specificity, resulting in off-target side effects like hepatotoxicity and GIT-related issues. Intravenous administration causes systemic side effects. The characteristic joint-localized symptoms such as pain, stiffness, and inflammation make the localized drug delivery suitable for managing arthritis. Topical/transdermal/intra-articular routes have become viable options for drug delivery in treating arthritis. However, challenges with those localized drug delivery routes include skin barrier and cartilage impermeability. Additionally, conventional intra-articular drug delivery also leads to rapid clearance of drugs from the synovial joint tissue. To circumvent these limitations, researchers have developed nanocarriers that enhance drug permeability through skin and cartilage, influencing localized action. Gel-based nanoengineered therapy employs a gel matrix to incorporate the drug-encapsulated nanocarriers. This approach combines the benefits of gels and nanocarriers to enhance therapeutic effects and improve patient compliance. This review emphasizes deep insights into drug delivery using diverse gel-based novel nanocarriers, exploring their various applications embedded in hyaluronic acid (biopolymer)-based gels, carbopol-based gels, and others. Furthermore, this review discusses the influence of nanocarrier pharmacokinetics on the localization and therapeutic manipulation of macrophages mediated by nanocarriers. The ELVIS (extravasation through leaky vasculature and inflammatory cell-mediated sequestration) effect associated with arthritis is advantageous in drug delivery. Simply put, the ELVIS effect refers to the extravasation of nanocarriers through leaky vasculatures, which finally results in the accumulation of nanocarriers in the joint cavity.
Correction: Successful closure of a refractory gastrobronchial fistula using endoscopic mucosal ablation followed by single loop-and-clips technique
Authors: Sandra Maisterra, Sergi Quintana-Carbo, Humberto Aranda, Mariona Calvo, Leandre Farran, Nuria Virgili, Joan B. Gornals
Journal: Endoscopy (2023)
Diaphragm Pacing in Early Critical Illness? A Plea for a Super-relaxed Approach
Authors: Leo Heunks, Dirk W. Donker, Eline Oppersma, Coen A. C. Ottenheijm, Jonne Doorduin
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Diaphragm Pacing in Early Critical Illness? A Plea for a Super-relaxed Approach." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Atorvastatin in Severity-stratified Pulmonary Sarcoidosis: A Phase II Randomized Controlled Trial
Authors: Joseph R. Fontana, Joel Moss, Dong-Yun Kim, Mario Stylianou, Stewart J Levine, Amisha V. Barochia, Nargues Weir, Les R. Folio, Huy Michael Do, Vincent Manganiello
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Atorvastatin in Severity-stratified Pulmonary Sarcoidosis: A Phase II Randomized Controlled Trial." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Ferroptosis Inhibition Combats Metabolic Derangements and Improves Cardiac Function in Pulmonary Artery Banded Pigs
Authors: Felipe Kazmirczak, Ryan Moon, Neal T. Vogel, Walt Tollison, Matt T. Lahti, John P. Carney, Jenna B. Mendelson, Todd Markowski, LeeAnn Higgins, Kevin Murray, Candace Guerrero, Kurt W Prins
Journal: American Journal of Respiratory and Critical Care Medicine (2024)
Long-Term Efficacy and Safety of Danicopan as Add-On Therapy to Ravulizumab or Eculizumab in PNH With Significant EVH
Authors: Austin Kulasekararaj, Morag Griffin, Caroline Piatek, Jamile Shammo, Jun-ichi Nishimura, Christopher Patriquin, Hubert Schrezenmeier, Wilma Barcellini, Jens Panse, Anna Gaya, Yogesh Patel, Peng Liu, Gleb Filippov, Flore Sicre de Fontbrune, Antonio Risitano, Jong Wook Lee
Journal: Blood (2024)

Complement C5 inhibitor treatment with ravulizumab or eculizumab for paroxysmal nocturnal hemoglobinuria (PNH) improves outcomes and survival. Some patients remain anemic due to clinically significant extravascular hemolysis (cs-EVH; hemoglobin [Hb] ≤9.5 g/dL and absolute reticulocyte count [ARC] ≥120 × 109/L). In the phase 3 ALPHA trial, participants received oral factor D inhibitor danicopan (150 mg 3 times daily) or placebo plus ravulizumab or eculizumab during the 12-week, double-blind treatment period 1 (TP1); those receiving placebo switched to danicopan during the subsequent 12-week, open-label TP2 and continued during the 2-year long-term extension (LTE). There were 86 participants randomized in the study, of whom 82 entered TP2, and 80 entered LTE. The primary end point was met, with Hb improvements from baseline at week 12 (least squares mean change, 2.8 g/dL) with danicopan. For participants switching from placebo to danicopan at week 12, improvements in mean Hb were observed at week 24. Similar trends were observed for the proportion of participants with ≥2 g/dL Hb increase, ARC, proportion of participants achieving transfusion avoidance, and Functional Assessment of Chronic Illness Therapy-Fatigue scale scores. Improvements were maintained up to week 72. No new safety signals were observed. The breakthrough hemolysis rate was 6 events per 100 patient-years. These long-term data demonstrate sustained efficacy and safety of danicopan plus ravulizumab/eculizumab for continued control of terminal complement activity, intravascular hemolysis, and cs-EVH in PNH. This trial was registered at www.clinicaltrials.gov as #NCT04469465.
Enhancing HBV-specific T cell responses through a combination of epigenetic modulation and immune checkpoint inhibition
Authors: Melanie Urbanek-Quaing, Yin-Han Chou, Manoj Kumar Gupta, Katja Steppich, Birgit Bremer, Hagen Schmaus, Katja Deterding, Benjamin Maasoumy, Heiner Wedemeyer, Cheng-Jian Xu, Anke R. M. Kraft, Markus Cornberg
Journal: Hepatology (2024)

Objective: Chronic HBV infection (CHB) exhausts HBV-specific T cells, develops epigenetic imprints that impair immune responses, and limits the effectiveness of immune checkpoint inhibitor (ICI) monotherapy, such as αPD-L1. This study aimed to determine whether the DNA methyltransferase inhibitor decitabine (DAC) could reverse these epigenetic imprints and enhance ICI efficacy in restoring HBV-specific T cell responses. Methods: We investigated HBV-specific T cell responses by 10-day in vitro stimulation of peripheral blood mononuclear cells (PBMCs) from patients with CHB. PBMCs were stimulated with HBV core-specific overlapping peptide pools and HLA-A*02-restricted peptides, core 18 and pol 455 . The immunomodulatory effect of the DAC/αPD-L1 combination was assessed by flow cytometry, and our analysis included clinical characteristics, ex vivo DNA methylation of PBMCs, and IFNγ plasma levels. Results: Treatment with DAC/αPD-L1 enhanced HBV-specific CD4 + T cell responses in a significant proportion of 53 patients, albeit with some variability. This effect was independent of the HBcrAg levels. Ex vivo DNA methylation revealed hypermethylation of key genes, such as IFNG among DAC-responders versus non-responders, supported by altered ex vivo IFNγ plasma levels. Further analysis of HBV-specific CD8 + T cell responses in 22 HLA-A*02-positive patients indicated distinct response patterns between core 18 and pol 455 stimulation, with pol 455 -specific CD8 + T cells showing increased susceptibility to DAC/αPD-L1, surpassing the αPD-L1 monotherapy response. Conclusions: The combination of DAC/αPD-L1 shows promise in improving HBV-specific T cell responses in vitro , highlighting the potential of remodeling exhaustion-associated epigenetic signatures to enhance HBV-specific T cell restoration and suggesting a novel immunotherapeutic avenue for CHB.
International trends in biliary tract cancer-related mortality, 2000–2022: An observational study of the World Health Organization mortality database
Authors: Quynh Thi Vu, Yoshito Nishimura, Ko Harada, Hiroki Ito, Tsukasa Higashionna, Akinari Maruo, Keisaku Harada, Tatsuaki Takeda, Hirofumi Hamano, Yoshito Zamami, Hideharu Hagiya, Toshihiro Koyama
Journal: Hepatology (2024)

Background &amp; Aims: Biliary tract cancers (BTCs), including intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma (eCCA), gallbladder cancer (GBC), and ampullary cancer, exhibit poor prognosis. This study examined temporal trends in mortality due to BTCs and their major subtypes at international, regional, and national levels. Approach &amp; Results: This observational study used the World Health Organization mortality database. Locally weighted regression (LOESS) was used to produce a smoothed curve of long-term international and regional BTC and major subtype-related mortality rates in 2000–2022 based on available data from countries. Trends in age-standardised mortality rates (ASRs) during 2013–2022 for individual countries were examined using joinpoint regression analysis. Internationally, LOESS-smoothed ASRs per 100,000 population due to BTCs were 2.8 (95% confidence interval: 2.5–3.1) in 2000, and 2.7 (2.3–3.1) in 2022. LOESS-smoothed BTC-related ASRs were the highest in the Western Pacific region at 4.2 (1.8–6.6) in 2022, compared with those in the European and American regions at 2.6 (2.3–2.9) and 2.2 (1.8–2.6), respectively. Among major subtypes, LOESS-smoothed ASRs due to iCCA increased by 120.0%, those due to GBC decreased by 45.5%, and those due to eCCA remained stable between 2000 and 2022. Disparities in BTC and major subtype-related ASR trends were observed between countries during 2013–2022, with iCCA-associated ASRs showing increasing trends in many countries. Conclusions: Although internationally estimated BTC-associated ASRs showed a stable trend over the last two decades, a large increase in estimated iCCA-associated ASRs necessitates developing effective screening for high-risk individuals and disease management strategies.
Approaching Hypercalcemia in Monoclonal Gammopathy of Undetermined Significance: Insights from the iStopMM study
Authors: Ástrún Helga Jónsdóttir, Helga Ágústa Sigurjónsdóttir, Sigrun Thorsteinsdottir, Thorir Einarsson Long, Ingigerður Sólveig Sverrisdóttir, Elias Eythorsson, Jon Thorir Oskarsson, Runólfur Pálsson, Olafur Skuli Indridason, Bryjnar Vidarsson, Pall T Onundarson, Isleifur Olafsson, Ingunn Þorsteinsdóttir, Bjarni A Agnarsson, Margret Sigurdardottir, Asbjorn Jonsson, Malin L. Hultcrantz, Brian G.M. Durie, Stephen Harding, Carl Ola Landgren, Thorvardur Jon Love, Sigurdur Yngvi Kristinsson, Sæmundur Rögnvaldsson
Journal: Blood (2024)
Optimising the paradigms of human AI collaborative clinical coding
Authors: Yue Gao, Yuepeng Chen, Minghao Wang, Jinge Wu, Yunsoo Kim, Kaiyin Zhou, Miao Li, Xien Liu, Xiangling Fu, Ji Wu, Honghan Wu
Journal: npj Digital Medicine (2024)

Abstract Automated clinical coding (ACC) has emerged as a promising alternative to manual coding. This study proposes a novel human-in-the-loop (HITL) framework, CliniCoCo. Using deep learning capacities, CliniCoCo focuses on how such ACC systems and human coders can work effectively and efficiently together in real-world settings. Specifically, it implements a series of collaborative strategies at annotation, training and user interaction stages. Extensive experiments are conducted using real-world EMR datasets from Chinese hospitals. With automatically optimised annotation workloads, the model can achieve F1 scores around 0.80–0.84. For an EMR with 30% mistaken codes, CliniCoCo can suggest halving the annotations from 3000 admissions with an ignorable 0.01 F1 decrease. In human evaluations, compared to manual coding, CliniCoCo reduces coding time by 40% on average and significantly improves the correction rates on EMR mistakes (e.g., three times better on missing codes). Senior professional coders’ performances can be boosted to more than 0.93 F1 score from 0.72.
ADAR1 is required for acute myeloid leukemia cell survival by modulating post-transcriptional Wnt signaling through impairing miRNA biogenesis
Authors: Zhongrui Shi, Jiaxing Li, Jiayu Ding, Yiwen Zhang, Wenjian Min, Yasheng Zhu, Yi Hou, Kai Yuan, Chengliang Sun, Xuejiao Wang, Hao Shen, Liping Wang, Shun-Qing Liang, Wenbin Kuang, Xiao Wang, Peng Yang
Journal: Leukemia (2024)
Safety and efficacy of GLP-1/FGF21 dual agonist HEC88473 in MASLD and T2DM: a randomized, double-blind, placebo-controlled study
Authors: Lin Xiang, Guixia Wang, Yulei Zhuang, Lin Luo, Jiangyu Yan, Hong Zhang, Xiaojiao Li, Can Xie, Qingwei He, Yuyu Peng, Hong Chen, Qianqian Li, Xiaoping Li, Linfeng Guo, Guoyue Lv, Yanhua Ding
Journal: Journal of Hepatology (2024)
SARS-CoV-2 introductions to the island of Ireland: a phylogenetic and geospatiotemporal study of infection dynamics
Authors: Alan M Rice, Evan P Troendle, Stephen J Bridgett, Behnam Firoozi Nejad, Jennifer M McKinley, Declan T Bradley, Derek J Fairley, Connor G G Bamford, Timofey Skvortsov, David A Simpson
Journal: Genome Medicine (2024)
Effectiveness of the primary Bacillus Calmette-Guérin vaccine against the risk of Mycobacterium tuberculosis infection and tuberculosis disease: a meta-analysis of individual participant data
Authors: Puck T Pelzer, Logan Stuck, Leonardo Martinez, Alexandra S Richards, Carlos Acuña-Villaorduña, Naomi E Aronson, Maryline Bonnet, Anna C Carvalho, Pei-Chun Chan, Li-Min Huang, Chi-Tai Fang, Gavin Churchyard, Helena Del Corral-Londoño, Manjula Datta, Marcos A Espinal, Katherine Fielding, Andrew J Fiore-Gartland, Alberto Garcia-Basteiro, Willem Hanekom, Mark Hatherill, Phillip C Hill, Helena Huerga, Edward C Jones-López, Afranio Kritski, Anna M Mandalakas, Punam Mangtani, Eduardo Martins Netto, Harriet Mayanja, Rufaida Mazahir, Megan Murray, Molebogeng Rangaka, Thomas Scriba, Jitendra Singh, Sarman Singh, Catherine M Stein, Johan Vekemans, Lilly M Verhagen, Julian A Villalba, Anne Wajja, Basilea Watson, Richard G White, Frank G J Cobelens
Journal: The Lancet Microbe (2024)
Increasing Life Expectancy in Patients with Genitourinary Malignancies: Impact of Treatment Burden on Disease Management and Quality of Life
Authors: Marie-Pier St-Laurent, Bernard Bochner, James Catto, Benjamin J Davies, Christian Daniel Fankhauser, Tullika Garg, Jill Hamilton-Reeves, Viraj Master, Bente T Jensen, Susanne V Lauridsen, Elizabeth Wulff-Burchfield, Sarah P Psutka
Journal: European Urology (2024)
Reactive oxygen species switcher via MnO2-coated Prussian blue loaded hyaluronic acid methacrylate hydrogel microspheres for local anti-tumor treatment
Authors: Huijie Han, Shiqi Wang, Mohammad-Ali Shahbazi, Inge S Zuhorn, Zhengwei Cai, Jie Chen, Jiachen Li, Yu Chen, Yawei Du, Raquel Bártolo, Liang Chen, Hélder A Santos, Wenguo Cui
Journal: Journal of Controlled Release (2024)