tbuckley/cabot-search huggingface dataset:
A new initiative for the <i>Journal of the National Cancer Institute</i>: supporting early career investigators
Authors: Mark E Sherman, Amanda L Boehm, Eduardo L Franco
Journal: JNCI Journal of the National Cancer Institute (2024)

Cancer Institute (JNCI) is piloting a new early career investigator initiative to address specific needs of early career investigators during this exciting period of rapid advances in medical research and changes in scientific publishing.This initiative was motivated by the recognition that early career investigators may benefit from additional support in navigating a complex publishing landscape, characterized by heightened competition; growth of team science; access to big data; transdisciplinarity; and complementary methods of communicating research, including social media.Furthermore, we acknowledge that scientific publishing has implications and responsibilities that extend beyond communication, as it impacts grant funding, reputational excellence, and career opportunities at a time when academic reward mechanisms are being reconsidered (2,3).The Journal appreciates that multiple factors, including established networks, a sustained body of funded research, and bibliometrics (especially if misapplied), may favor established investigators, thereby concentrating opportunities and resources within a shrinking pool of experienced researchers.Data suggest that early career investigators who achieve early career success in funding applications obtain a durable advantage, whereas those whose proposals fall narrowly below thresholds face less promising funding trajectories, and sometimes discouragement, termed the Matthew effect (4).To counter that, thus addressing the imperative of developing the most talented biomedical research workforce, the US National Institutes of Health has developed multiple initiatives to strengthen the competitiveness of early career investigator applications (5).The JNCI Early Career Investigator Initiative is aligned and complementary with the goals of supporting early career investigators, regardless of the home country for their research.Early career investigators have a pressing need to publish high-impact manuscripts that support grant applications, promotion, and tenure.Although publishing in JNCI is an achievement for all researchers, lack of experience with complex submission processes, intense scrutiny, the need for manuscript revisions, and publication costs may be prohibitive for early
Microneedle Patches‐Integrated Transdermal Bioelectronics for Minimally Invasive Disease Theranostics
Authors: Zifeng Wang, Min Xiao, Zhanhong Li, Xinghao Wang, Fangjie Li, Huayuan Yang, Yu Chen, Zhigang Zhu
Journal: Advanced Healthcare Materials (2024)

Abstract Wearable epidermal electronics with non‐ or minimally‐invasive characteristics can collect, transduce, communicate, and interact with accessible physicochemical health indicators on the skin. However, due to the stratum corneum layer, rich information about body health is buried under the skin stratum corneum layer, for example, in the skin interstitial fluid. Microneedle patches are typically designed with arrays of special microsized needles of length within 1000 µm. Such characteristics potentially enable the access and sample of biomolecules under the skin or give therapeutical treatment painlessly and transdermally. Integrating microneedle patches with various electronics allows highly efficient transdermal bioelectronics, showing their great promise for biomedical and healthcare applications. This comprehensive review summarizes and highlights the recent progress on integrated transdermal bioelectronics based on microneedle patches. The design criteria and state‐of‐the‐art fabrication techniques for such devices are initially discussed. Next, devices with different functions, including but not limited to health monitoring, drug delivery, and therapeutical treatment, are highlighted in detail. Finally, key issues associated with current technologies and future opportunities are elaborated to sort out the state of recent research, point out potential bottlenecks, and provide future research directions.
PAA‐PU Janus Hydrogels Stabilized by Janus Particles and its Interfacial Performance During Hemostatic Processing
Authors: Yan Fang, Yanyan Zheng, Chongyi Chi, Sai Jiang, Wanbang Qin, Yicheng Zhang, Haiqing Liu, Qinhui Chen
Journal: Advanced Healthcare Materials (2024)

Abstract Hydrogel is a very promising dressing for hemostasis and wound healing due to its good adhesion and long‐term moist environment. However, secondary injury caused by tissue adhesion due to homogeneous hydrogel cannot be ignored. The obvious interface existing in Janus hydrogel will weaken its asymmetric function. Here, a hierarchical adhesive polyacrylic acid–polyurushiol water–oil Janus hydrogel (JPs@PAA‐PU) without adhesive layer is fabricated by one‐pot method in the stabilization of polystyrene@silica‐siliver Janus particles (JPs). The morphological structure, mechanical properties, anisotropic chemical composition, and adhesion performance, in vivo, and in vitro hemostatic properties of Janus hydrogel are investigated. Result shows that the obtained Janus hydrogel possesses obvious compartmentalization in microstructure, functional groups, and chemical elements. Janus hydrogel is provided with asymmetric interfacial toughness with top 52.45 ± 2.29 Kpa and bottom 7.04 ± 0.88 Kpa on porcine liver. The adhesion properties of PAA side to tissue, red blood cells and platelets, promoting effect of PU side on coagulation cascade reaction and its physical battier endow Janus hydrogel with shorter hemostatic time and less blood loss than control group. It also exhibits excellent antibacterial effects against Escherichia coli and Staphylococcus aureus (&gt;90%). Janus hydrogel possesses biosafety, providing safety guarantee for clinical applications in the future.
Long‐term follow‐up of <scp>VIALE‐A</scp>: Venetoclax and azacitidine in chemotherapy‐ineligible untreated acute myeloid leukemia
Authors: Keith W. Pratz, Brian A. Jonas, Vinod Pullarkat, Michael J. Thirman, Jacqueline S. Garcia, Hartmut Döhner, Christian Récher, Walter Fiedler, Kazuhito Yamamoto, Jianxiang Wang, Sung‐Soo Yoon, Ofir Wolach, Su‐Peng Yeh, Brian Leber, Jordi Esteve, Jiri Mayer, Kimmo Porkka, Árpád Illés, Roberto M. Lemoli, Mehmet Turgut, Grace Ku, Catherine Miller, Ying Zhou, Meng Zhang, Brenda Chyla, Jalaja Potluri, Courtney D. DiNardo
Journal: American Journal of Hematology (2024)

Abstract Venetoclax‐azacitidine is approved for treatment of patients with newly diagnosed acute myeloid leukemia (AML) ineligible for intensive chemotherapy based on the interim overall survival (OS) analysis of the VIALE‐A study (NCT02993523). Here, long‐term follow‐up is presented to address survival benefit and long‐term outcomes with venetoclax‐azacitidine. Patients with newly diagnosed AML who were ineligible for intensive chemotherapy were randomized 2:1 to receive venetoclax‐azacitidine or placebo‐azacitidine. OS was the primary endpoint; complete remission with/without blood count recovery (CR/CRi) was a key secondary endpoint. This final analysis was conducted when 100% of the predefined 360 OS events occurred. In VIALE‐A, 431 patients were enrolled to venetoclax‐azacitidine ( n = 286) or placebo‐azacitidine ( n = 145). At 43.2 months median follow‐up, median OS was 14.7 months (95% confidence interval [CI], 12.1–18.7) with venetoclax‐azacitidine, and 9.6 months (95% CI, 7.4–12.7) with placebo‐azacitidine (hazard ratio, 0.58 [95% CI, 0.47–0.72], p &lt; .001); the estimated 24‐month OS rate was 37.5% and 16.9%, respectively. Median OS for patients with IDH1/2 mutations and those with measurable residual disease responses was reached in this final analysis. CR/CRi rate was similar to interim analysis. Any‐grade hematologic and gastrointestinal adverse events were most common in venetoclax‐azacitidine and placebo‐azacitidine arms, including thrombocytopenia (47% and 42%) and neutropenia (43% and 29%). No new safety signals were identified. Long‐term efficacy and safety confirm venetoclax‐azacitidine is an improvement in standard‐of‐care for patients with AML who are not eligible for intensive chemotherapy because of advanced age or comorbidities.
Exploring the association between cognitive activity and symptom resolution following concussion in adolescents aged 11–17 years
Authors: Jingzhen Yang, Enas Alshaikh, Nichole Asa, Olivia VonDeylen, Nikhil Desai, Hudson Gerry Taylor, Thomas Pommering, James P MacDonald, Daniel M Cohen, Keith Owen Yeates
Journal: British Journal of Sports Medicine (2024)

Objective As opposed to postconcussion physical activity, the potential influence of cognitive activity on concussion recovery is not well characterised. This study evaluated the intensity and duration of daily cognitive activity reported by adolescents following concussion and examined the associations between these daily cognitive activities and postconcussion symptom duration. Methods This study prospectively enrolled adolescents aged 11–17 years with a physician-confirmed concussion diagnosis within 72 hours of injury from the emergency department and affiliated concussion clinics. Participants were followed daily until symptom resolution or a maximum of 45 days postinjury to record their daily cognitive activity (intensity and duration) and postconcussion symptom scores. Results Participants (n=83) sustained their concussion mostly during sports (84%), had a mean age of 14.2 years, and were primarily male (65%) and white (72%). Participants reported an average of 191 (SD=148), 166 (SD=151) and 38 (SD=61) minutes of low-intensity, moderate-intensity and high-intensity daily cognitive activity postconcussion while still being symptomatic. Every 10 standardised minutes per hour increase in moderate-intensity or high-intensity cognitive activities postconcussion was associated with a 22% greater rate of symptom resolution (adjusted hazard ratio (aHR) 1.22, 95% CI 1.01 to 1.47). Additionally, each extra day’s delay in returning to school postconcussion was associated with an 8% lower rate of symptom resolution (aHR 0.92, 95% CI 0.85 to 0.99). Conclusion In adolescents with concussion, more moderate-high intensity cognitive activity is associated with faster symptom resolution, and a delayed return to school is associated with slower symptom resolution. However, these relationships may be bidirectional and do not necessarily imply causality. Randomised controlled trials are needed to determine if exposure to early cognitive activity can promote concussion recovery in adolescents.
Platelet Vesicles Synergetic with Biosynthetic Cellulose Aerogels for Ultra‐Fast Hemostasis and Wound Healing
Authors: Ying Wang, Yicheng Guo, Yuqing Liu, Xiaohong Zhao, Yong Huang, Xiaorong Zhang, Xiaohong Hu, Kibret Mequanint, Gaoxing Luo, Malcolm Xing
Journal: Advanced Healthcare Materials (2024)

Abstract Achieving hemostasis in penetrating and irregular wounds is challenging because the hemostasis factor cannot arrive at the bleeding site, and substantial bleeding will wash away the blood clot. Since the inherently gradual nature of blood clot formation takes time, a physical barrier is needed before blood clot formation. Herein, an ultra‐light and shape memory hemostatic aerogel consisting of oxidized bacterial cellulose (OBC) and platelet extracellular vesicles (pVEs) is reported. The OBC‐pVEs aerogel provides a physical barrier for the bleeding site by self‐expansion, absorbing the liquid from blood to concentrate platelets and clotting factors and accelerating the clot formation by activating platelets and transforming fibrinogen into fibrin. In the rat liver and tail injury models, the blood loss decreases by 73% and 59%, and the bleeding times are reduced by 55% and 62%, respectively. OBC‐pVEs aerogel has also been shown to accelerate wound healing. In conclusion, this work introduces an effective tool for treating deep, non‐compressible, and irregular wounds and offers valuable strategies for trauma bleeding and wound treatment.
Promoting Positive Development Among Racially and Ethnically Marginalized Youth: Advancing a Novel Model of Natural Mentoring
Authors: Noelle M. Hurd
Journal: Annual Review of Clinical Psychology (2024)

Racism and other forms of oppression threaten the well-being of racially and ethnically marginalized youth. Models of risk and resilience for marginalized youth have stressed the importance of addressing contextual and structural risk while emphasizing promotive factors such as cultural capital within their communities. Increasingly, research has focused on collective antiracist action as a form of coping with structural oppression. Importantly, supportive intergenerational relationships that develop within youths’ everyday contexts may play a key role in catalyzing and reinforcing youths’ engagement in antiracist action. This review advances a novel model for understanding how supportive nonparental adults from youths’ everyday lives (i.e., natural mentors) influence youths’ positive developmental outcomes and participation in antiracist action and how collective antiracist action, in turn, fosters liberation and racial justice. The creation of a more just and equitable society contributes to positive development among racially and ethnically marginalized youth.
Epidemiology of Mass Shootings in the United States
Authors: Jillian K. Peterson, James A. Densley, Molly Hauf, Jack Moldenhauer
Journal: Annual Review of Clinical Psychology (2024)

This in-depth review delves into the multifaceted realm of mass shootings and explores their epidemiology from a psychological perspective. The article presents a comprehensive examination of the prevalence, perpetrator and victim profiles, motives, and contributing factors associated with mass shootings. By investigating the intricate relationship between masculinity, domestic violence, military service, social media, fame-seeking, suicidal ideation, mental illness, and firearms, this article sheds light on the multifaceted nature of mass shootings. Moreover, it discusses the importance of implementing effective prevention strategies to address this growing public health concern. The findings from this review serve as a valuable resource for researchers, practitioners, policy makers, and the community at large, facilitating a deeper understanding of mass shootings and fostering the development of evidence-based solutions to prevent these tragic incidents.
Impact of Acute Alcohol Consumption on Sexuality: A Look at Psychological Mechanisms
Authors: William H. George, Jessica A. Blayney, Kelly Cue Davis
Journal: Annual Review of Clinical Psychology (2024)

Alcohol's link with sexuality is long-standing and prominent. While research continues to document robust associations between drinking and sexual behavior, scientific attention now centers primarily on evaluating mechanisms and attendant theoretical frameworks to advance our understanding of how alcohol exerts a causal impact. We describe four domains with reliable evidence of alcohol effects: sexualized social perceptions, sexual arousal, sexual risk taking, and sexual assault. We consider three contextual frames: distal factors associated with encountering opportunities for alcohol-involved sex, proximal factors associated with alcohol's acute effects, and distal–proximal interactions. We then examine the empirical support for mechanisms embedded within four theoretical frameworks: alcohol disinhibition, alcohol expectancy, alcohol myopia, and emotion regulation. Support for disinhibition mechanisms is evident with sexual arousal only. Expectancy and myopia mechanisms enjoy support across domains and make up bases for integrative expectancy–myopia causal explanations. Emotion regulation mechanisms evidence preliminary support in risk taking and sexual assault. Implications and future directions are considered.
Missing Data Analysis
Authors: Roderick J. Little
Journal: Annual Review of Clinical Psychology (2024)

Methods for handling missing data in clinical psychology studies are reviewed. Missing data are defined, and a taxonomy of main approaches to analysis is presented, including complete-case and available-case analysis, weighting, maximum likelihood, Bayes, single and multiple imputation, and augmented inverse probability weighting. Missingness mechanisms, which play a key role in the performance of alternative methods, are defined. Approaches to robust inference, and to inference when the mechanism is potentially missing not at random, are discussed.
Intrahepatic Transcriptomics Differentiate Advanced Fibrosis and Clinical Outcomes in Adults With Fontan Circulation
Authors: Katia Bravo-Jaimes, Xiuju Wu, Leigh C. Reardon, Gentian Lluri, Jeannette P. Lin, Jeremy P. Moore, Glen van Arsdell, Reshma Biniwale, Ming-Sing Si, Bita V. Naini, Robert Venick, Sammy Saab, Christopher L. Wray, Reid Ponder, Carl Rosenthal, Alexandra Klomhaus, Kristina I. Böstrom, Jamil A. Aboulhosn, Fady M. Kaldas
Journal: Journal of the American College of Cardiology (2024)
Effect of a Salt Substitute on Incidence of Hypertension and Hypotension Among Normotensive Adults
Authors: Xianghui Zhang, Yifang Yuan, Chenglong Li, Xiangxian Feng, Hongxia Wang, Qianku Qiao, Ruijuan Zhang, Aoming Jin, Jiayu Li, Huijuan Li, Yangfeng Wu
Journal: Journal of the American College of Cardiology (2024)
Adult Strabismus Preferred Practice Pattern®
Authors: Linda R. Dagi, Federico G. Velez, Jonathan M. Holmes, Steven M. Archer, Mitchell B. Strominger, Stacy L. Pineles, Evelyn A. Paysse, Matthew Simon Pihlblad, Hatice Tuba Atalay, Brian N. Campolattaro, Yoon-Hee Chang
Journal: Ophthalmology (2024)
Opportunities in the Postpartum Period to Reduce Cardiovascular Disease Risk After Adverse Pregnancy Outcomes: A Scientific Statement From the American Heart Association
Authors: Jennifer Lewey, Theresa M. Beckie, Haywood L. Brown, Susan D. Brown, Vesna D. Garovic, Sadiya S. Khan, Eliza C. Miller, Garima Sharma, Laxmi S. Mehta
Journal: Circulation (2024)

Adverse pregnancy outcomes are common among pregnant individuals and are associated with long-term risk of cardiovascular disease. Individuals with adverse pregnancy outcomes also have an increased incidence of cardiovascular disease risk factors after delivery. Despite this, evidence-based approaches to managing these patients after pregnancy to reduce cardiovascular disease risk are lacking. In this scientific statement, we review the current evidence on interpregnancy and postpartum preventive strategies, blood pressure management, and lifestyle interventions for optimizing cardiovascular disease using the American Heart Association Life's Essential 8 framework. Clinical, health system, and community-level interventions can be used to engage postpartum individuals and to reach populations who experience the highest burden of adverse pregnancy outcomes and cardiovascular disease. Future trials are needed to improve screening of subclinical cardiovascular disease in individuals with a history of adverse pregnancy outcomes, before the onset of symptomatic disease. Interventions in the fourth trimester, defined as the 12 weeks after delivery, have great potential to improve cardiovascular health across the life course.
Precision treatment in advanced hepatocellular carcinoma
Authors: Xupeng Yang, Chen Yang, Shu Zhang, Haigang Geng, Andrew X. Zhu, René Bernards, Wenxin Qin, Jia Fan, Cun Wang, Qiang Gao
Journal: Cancer Cell (2024)

The past decade has witnessed significant advances in the systemic treatment of advanced hepatocellular carcinoma (HCC). Nevertheless, the newly developed treatment strategies have not achieved universal success and HCC patients frequently exhibit therapeutic resistance to these therapies. Precision treatment represents a paradigm shift in cancer treatment in recent years. This approach utilizes the unique molecular characteristics of individual patient to personalize treatment modalities, aiming to maximize therapeutic efficacy while minimizing side effects. Although precision treatment has shown significant success in multiple cancer types, its application in HCC remains in its infancy. In this review, we discuss key aspects of precision treatment in HCC, including therapeutic biomarkers, molecular classifications, and the heterogeneity of the tumor microenvironment. We also propose future directions, ranging from revolutionizing current treatment methodologies to personalizing therapy through functional assays, which will accelerate the next phase of advancements in this area.
Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth
Authors: Michael S. Samuel, Jose I. Lopez, Ewan J. McGhee, Daniel R. Croft, David Strachan, Paul Timpson, June Munro, Ewald Schröder, Jing Zhou, Valerie G. Brunton, Nick Barker, Hans Clevers, Owen J. Sansom, Kurt I. Anderson, Valerie M. Weaver, Michael F. Olson
Journal: Cancer Cell (2024)
The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells
Authors: Ning-Ning Liu, Cheng-Xiang Yi, Lu-Qi Wei, Jin-An Zhou, Tong Jiang, Cong-Cong Hu, Lu Wang, Yuan-Yuan Wang, Yun Zou, Yi-Kai Zhao, Le-Le Zhang, Ya-Ting Nie, Yi-Jing Zhu, Xin-Yao Yi, Ling-Bing Zeng, Jing-Quan Li, Xiao-Tian Huang, Hong-Bin Ji, Zisis Kozlakidis, Lin Zhong, Christopher Heeschen, Xiao-Qi Zheng, Changbin Chen, Peng Zhang, Hui Wang
Journal: Cancer Cell (2024)
Airway smooth muscle and long-term clinical efficacy following bronchial thermoplasty in severe asthma
Authors: Pieta C Wijsman, Annika W M Goorsenberg, Julia N S d’Hooghe, Nick H T ten Hacken, Joris J T H Roelofs, Thais Mauad, Els J M Weersink, Pallav Shah, Jouke T Annema, Peter I Bonta
Journal: Thorax (2024)

The mechanism of action of bronchial thermoplasty (BT) treatment for patients with severe asthma is incompletely understood. This study investigated the 2.5-year impact of BT on airway smooth muscle (ASM) mass and clinical parameters by paired data analysis in 22 patients. Our findings demonstrate the persistence of ASM mass reduction of &gt;50% after 2.5 years. Furthermore, sustained improvement in asthma control, quality of life and exacerbation rates was found, which is in line with previous reports. An association was found between the remaining ASM and both the exacerbation rate (r=0.61, p=0.04 for desmin, r=0.85, p&lt;0.01 for alpha smooth muscle actin (SMA)) and post-bronchodilator forced expiratory volume in 1 s predicted percentage (r=−0.69, p=0.03 for desmin, r=−0.58, p=0.08 for alpha SMA). This study provides new insight into the long-term impact of BT.
Robust miniature Cas-based transcriptional modulation by engineering Un1Cas12f1 and tethering Sso7d
Authors: Xiangnan Wang, Lingyun Li, Li Guo, Ying Feng, Zengming Du, Wei Jiang, Xia Wu, Jing Zheng, Xiao Xiao, Hui Zheng, Yadong Sun, Hanhui Ma
Journal: Molecular Therapy (2024)
Publisher Correction: The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+T cell fates
Authors: Xin Zhao, Wei Hu, Sung Rye Park, Shaoqi Zhu, Shengen Shawn Hu, Chongzhi Zang, Weiqun Peng, Qiang Shan, Hai-Hui Xue
Journal: Nature Immunology (2024)