tbuckley/cabot-search huggingface dataset:
Hematology: An Atlas and Diagnostic Guide.
Authors: Eric F. Glassy, Nora C. J. Sun
Journal: Annals of Internal Medicine (1983)

ous (non\p=n-\specialedition)  Books; none of  reviewers include an adolescent medicine specialist, and only two are even pediatricians! The   series is well known for its ability to provide short but incisive reviews of  current literature in nearly any field. The reader's expectation on buying this volume is that  field of adolescent medicine will be deftly reviewed in  same manner as other   series have dealt with other fields. Unfortunately, this is not true. By using  Year Book name for this volume,  pub¬ lishers have unintentionally misled po¬ tential readers. In short, this is a volume that is improperly advertised and would be useful only to an academic adolescent medicine specialist. In his introduc¬ tion, Shearin rightfully informs us that the number of articles dealing with adolescents and young adults has grown in recent years ... I was pleas¬ antly surprised at  wealth of mate¬ rial available. I cannot think of a better rationale for a yearbook of ado¬ lescent medicine that would include articles published primarily about adolescents and reviewed by adoles¬ cent medicine specialists. VICTOR C. STRASBURGER, MD Department of Adolescent Medicine Bridgeport Hospital 267 Grant St PO Box 5000 Bridgeport, CT 06610
Hyaluronan inhibits MAP kinase signalling cascade and vascular stenosis after balloon catheter injury.
Authors: R.C. Savani, K Sangster, P Liu, G Hou, P Wang, S Asculai, S Gustafson, E.A. Turley
Journal: Circulation Research (1998)

Hyaluronan inhibits MAP kinase signalling cascade and vascular stenosis after balloon catheter injury.
Decision Making in Gastroenterology.
Authors: Joel S. Levine
Journal: Annals of Internal Medicine (1986)

Outline of Contents: Nutrition Clinical utility of procedures Infection in the gastrointestinal tract Evaluation of gastrointestinal symptoms Evaluation of signs of gastrointestinal disease Systemic disease and the gastrointestinal tract Diseases of the esophagus Diseases of the stomach and duodenum Diseases of the pancreas Diseases of the small intestine Diseases of the biliary tree Diseases of the colon Diseases of the abdominal vasculature and supportive tissues Diseases of the liver.
Emotion regulation as a main mechanism of change in psychotherapy
Authors: Natali Moyal, Noga Cohen, Avishai Henik, Gideon E. Anholt
Journal: Behavioral and Brain Sciences (2015)

Abstract A model that suggests reconsolidation of traumatic memories as a mechanism of change in therapy is important, but problematic to generalize to disorders other than post-traumatic and acute-stress disorder. We suggest that a more plausible mechanism of change in psychotherapy is acquisition of adaptive emotion regulation strategies.
Medical Care and Rehabilitation of the Aged and Chronically Ill.
Authors: Freddy Homburger, Charles D. Bonner
Journal: Annals of Internal Medicine (1965)

Aged and Chronically Ill. Ed 2. By Freddy Homburger and Charles D. Bonner. Price, $9.50. Pp 320, with 1 illustration. Little, Brown & Co., 34 Beacon St, Boston 02106, 1964. I am not sure what I am going to do with my review copy of this work. A friend of mine has just taken charge of a Geriatric Home, and it would, of course, be indispensable for her. Her need (at the moment) is greater than mine; but I can't help feeling she would derive much more benefit if she paid for a copy out of her own pocket. (She might then actually read it.) Perhaps I could sell her my copy and with the proceeds buy one for myself? Certainly I shall insist on having my own copy when, 20 to 30 years hence, it may be necessary to check what people are doing to me. Whatever disabilities I may develop (apart from my favorite psychoses) are all there. I shall
Intimate Partner Violence Among Men and Women in South Carolina, 1998
Authors: Ann L. Coker, Christina Derrick, Julia L. Lumpkin, Robert Oldendick, R H Potter
Journal: MMWR Morbidity and Mortality Weekly Report (2000)

This report summarizes the results of the survey conducted by the South Carolina Department of Health and Environmental Control and the University of South Carolina.  The purpose of the survey was to estimate the lifetime incidence of intimate partner violence (IPV) by type of violence (e.g. physical sexual and perceived emotional abuse) and to explore demographic correlates of reporting IPV among men and women.  Data were collected using a population-based random-digit-dialed telephone survey of adults in the state.  Overall findings revealed that approximately 25% of women and 13% of men surveyed have experienced some type of IPV during their lifetime.  Although women were significantly more likely to report physical and sexual IPV men were as likely as women to report emotional abuse without concurrent physical or sexual IPV.
Are chronic psychiatric patients at increased risk for developing breast cancer?
Authors: U Halbreich, J Shen, V Panaro
Journal: American Journal of Psychiatry (1996)

The authors' goal was to assess the incidence of breast cancer among chronic psychiatric patients.They reviewed mammograms and charts of 275 female patients over the age of 40 in a state psychiatric hospital and 928 women of comparable age at a general hospital radiology clinic.The incidence of breast cancer documented by pathology reports among the psychiatric patients was more than 3.5 times higher than that of patients at the general hospital and 9.5 times higher than the reported incidence in the general population.If confirmed, the suspected higher incidence of breast cancer among the psychiatric patients might be due to medications and further underscores the need for screening mammograms for breast cancer in these patients.
Young Male Drivers
Authors: Stanley H. Schuman
Journal: JAMA (1967)

A pilot sample of 288 unmarried male drivers aged 16 to 24 years were interviewed concerning their driving habits, attitudes, accidents, and violations. Differences between successive age groups indicated distinct developmental changes: graduation of the inexperienced, impulsive, but cautious beginner to a self-confident, financially independent, heavier drinking, and more dangerous young adult. Both accident-prone and violation-prone drivers appeared to use the automobile to express impulses. Both sets were more likely to have "working class" characteristics. Accidents also rose simply with exposure (miles driven), but violations did not.
War Nursing. A Text-Book for the Auxiliary Nurse.
Authors: Minnie Goodnow
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5101: Optimism, Hostility and Incident Coronary Heart Disease and Mortality in the Women’s Health Initiative
Authors: Hilary A Tindle, Yuefang Chang, Lewis H Kuller, JoAnn E Manson, Jennifer G Robinson, Milagros C Rosal, Greg J Siegle, Karen A Matthews
Journal: Circulation (2008)

Background  - Anger/hostility predicts cardiovascular disease (CVD). Less is known about positive attributes such as trait optimism, which is the expectation that good things will happen, and CVD risk. Optimism and hostility have not been extensively studied in post-menopausal women.   Methods  - We analyzed data from 107,356 Women’s Health Initiative participants (98,378 white, 8978 black) free of chronic disease at baseline. Optimism was assessed by the Life Orientation Test-Revised and hostility was assessed by the Cook Medley Questionnaire (cynicism subscale). Chi-square analyses were used to determine the association of optimism and hostility with baseline risk factors, and multivariable Cox proportional hazard models were used to determine whether optimism and hostility independently influenced incident coronary heard disease (CHD, composite endpoint of myocardial infarction, angina, or coronary artery bypass surgery) and total mortality over ~ 8 years of follow up.   Results  - Optimists were less likely, and hostile women more likely, to be hypertensive, diabetic, and smokers (p    Conclusion  - High optimism was associated with favorable health outcomes. High hostility was associated with increased risk of all-cause mortality. For mortality, results were more striking in blacks. Further research is needed to understand why and how optimism and hostility relate to CVD in women in order to develop targeted, efficacious interventions to modify these attitudes.
Guidelines for GPs are being tested
Authors: I. Purves
Journal: BMJ (1996)

will be made available to vendors of general practitioner and hospital software for incorporation in their systems, whether on DOS or other platforms.Copies of the BNF are purchased by the Department of Health in bulk and then provided free to doctors and pharmacists working for the NHS.No such arrangement exists at present for the electronic version, which is available only through the publishers (BMA and the Royal Pharmaceutical Society ofGreat Britain).The stand alone eBNF runs adequately on personal computers with a 386 processor, though a more powerful processor and more memory will increase its speed.The stand alone eBNF is run from the hard disk.Most new non-clinical software that clinicians may want to use runs under Win- dows; users are therefore likely to replace their systems with newer hardware that will run such software.
Changes In Health Status and Quality of Life In Adults with Thalassemia: Year 1 Report of the Thalassemia Longitudinal Cohort Study.
Authors: Amy Sobota, Robert Yamashita, Yan Xu, Felicia Trachtenberg, Pamela Kohlbry, Dorothy A Kleinert, Patricia Giardina, Janet L Kwiatkowski, Dru Haines, Vivekanandan Thayalasuthan, John B. Porter, Alexis A. Thompson, Leann Schilling, Charles T. Quinn, Ellis J. Neufeld
Journal: Blood (2010)
Nucleic Acid Content of the Thymic Cells of Normal and Irradiated C57BL Mice&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Patricia P. Weymouth, Norman E. Delfel, Ruth J. Doell, Helene L. Steinbock, Henry S. Kaplan
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article Nucleic Acid Content of the Thymic Cells of Normal and Irradiated C57BL Mice Get access Patricia P. Weymouth, Patricia P. Weymouth Department of Radiology, Stanford University School of Medicine, San Francisco, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar Norman E. Delfel, Norman E. Delfel Department of Radiology, Stanford University School of Medicine, San Francisco, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ruth J. Doell, Ruth J. Doell Department of Radiology, Stanford University School of Medicine, San Francisco, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar Helene L. Steinbock, Helene L. Steinbock Department of Radiology, Stanford University School of Medicine, San Francisco, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar Henry S. Kaplan Henry S. Kaplan Department of Radiology, Stanford University School of Medicine, San Francisco, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 4, February 1955, Pages 981–990, https://doi.org/10.1093/jnci/15.4.981 Published: 01 February 1955 Article history Received: 27 October 1954 Published: 01 February 1955
Effect of pregnancy on microvascular complications in the diabetes control and complications trial. The Diabetes Control and Complications Trial Research Group.
Journal: Diabetes Care (2000)

OBJECTIVE: To assess the effect of pregnancy on the development and progression of retinopathy and microalbuminuria in type 1 diabetes. RESEARCH DESIGN AND METHODS: We conducted longitudinal analyses of the Diabetes Control and Complications Trial (DCCT), a multicenter controlled clinical trial that compared intensive treatment with conventional diabetes therapy and studied 180 women who had 270 pregnancies and 500 women who did not become pregnant during an average of 6.5 years of follow-up. Women assigned to the conventional treatment group were changed to intensive therapy if they were planning pregnancy or as soon as possible after conception. Fundus photography was performed every 6 months, and the urinary albumin excretion rate (AER) was measured annually. RESULTS: Compared with nonpregnant women, pregnant women had a 1.63-fold greater risk of any worsening of retinopathy from before to during pregnancy (P &amp;lt; 0.05) in the intensive treatment group; the risk was 2.48-fold greater for pregnant vs. not pregnant women in the conventional group (P &amp;lt; 0.001). In the conventional group, the odds of &amp;gt; or =3-step progression from the baseline retinopathy level was &amp;gt;2.9-fold among pregnant vs. not pregnant women (P = 0.003). The odds ratio (OR) peaked during the second trimester (OR = 4.26, P = 0.001) and persisted as long as 12 months postpregnancy (OR = 2.87, P = 0.005). The level of AER during pregnancy in the intensive group, but not in the conventional group, was significantly elevated from the level at baseline, albeit in the normal range. Although individual patients had transient worsening of retinopathy during pregnancy, even to the proliferative level, at the end of the DCCT, mean levels of retinopathy and albuminuria in subjects who had become pregnant were similar to those in subjects who had not become pregnant within each treatment group. CONCLUSIONS: Pregnancy in type 1 diabetes induces a transient increase in the risk of retinopathy; increased ophthalmologic surveillance is needed during pregnancy and the first year postpartum. The long-term risk of progression of early retinopathy and albumin excretion, however, does not appear to be increased by pregnancy.
Meta-analyses of randomized trials assessing the interest of postoperative adjuvant chemotherapy and prognostic factors in gastric cancer
Authors: M. E. Buyse, J. Pignon
Journal: Journal of Clinical Oncology (2009)

4539 Background: Despite potentially curative resection of stomach cancer, 50%-90% of patients die of disease relapse. Numerous randomized clinical trials (RCTs) compared surgery alone (S) to adjuvant chemotherapy (S+CT), but definitive evidence is lacking. Our group has initiated an individual patient data (IPD)-based meta-analysis of all RCTs in the adjuvant gastric setting to quantify the potential benefit of S+CT over S, to study the role of various prognostic factors and their potential interactions with treatments. Methods: All RCTs closed to accrual at the end of 2003 were eligible. Trials with radiotherapy, intraperitoneal chemotherapy, or immunotherapy were excluded. The primary endpoint was OS, the secondary endpoint DFS. Baselines variables included age, sex, tumour size (T) and stage, type of resection (D0, D1, D2 or more), performance status (PS) and geographic area. The Logrank test was stratified by trial and treatment arm. Interaction with treatment was explored with Cox model stratified on trial. No multivariate analysis was performed due to the numerous missing data. Results: Thirty-one eligible RCTs (6,613 patients) were identified. As of December 2008, IPD were available from 16 trials (3,710 patients) with a median follow-up exceeding 8 years. OS benefit was significantly in favour of CT (HR=0.83, 95% CI 0.76–0.91, p &lt;0.0001) with absolute benefit of 6.3% at 5 years. Were associated with lower survival, older age (&gt;66 vs &lt;50) (HR=1.51, 95%CI= 1.31–1.73), PS2 (HR=1.71, 95%CI=1.35–2.15), higher UICC stage (HR=1.41 per unit 95%CI=1.35–1.46) and T&gt;1 (HR=1.57 per unit, 95%CI=1.47–1.67). There was also a strong geographical influence on prognosis (HR=0.30, 95%CI 0.26–0.34 and HR=1.26, 95%CI 1.13–1.41, respectively in Asia and in the US as compared to Europe). Treatment interactions were not identified for all but the stage. Treatment effect appeared slightly stronger for patients with higher stages (HR for treatment effect from 0.88 in stage I to 0.66 in stage IV). Conclusions: Our interim results show a modest but significant OS benefit in favour of adjuvant CT and confirm the impact of tumour staging as well as age and PS on OS. Asian patients have a much better survival than other patients. No significant financial relationships to disclose.
Abstract 3193: The Progression From Concentric Left Ventricular Hypertrophy to Reduced Left Ventricular Ejection Fraction is Not Common After 7 Years
Authors: Arun Krishnamoorthy, J. Eduardo Rame, Sachin Gupta, Parag C Patel, David W Markham, Mark H Drazner
Journal: Circulation (2009)

Introduction Whether concentric left ventricular (LV) hypertrophy (LVH) is a common precursor to depressed LV ejection fraction (EF) in humans is uncertain. We previously demonstrated that this tra...
Relationship of breast cancer stem cells (CSCs) and chronic O<sub>2</sub>/glucose deprivation (C-OGD).
Authors: M. Quintela-Fandino, E. Arpaia, R. Cairns, H. Blaser, M. W. Tusche, R. Colomer, A. Rufini, A. Wakeham, T. W. Mak
Journal: Journal of Clinical Oncology (2010)

10509 Background: The Warburg effect (WE) states that cancer cells obtain > 90% of their ATP from glycolysis (GLY). However, sustained WE is energetically inefficient and can lead to glucose (G) depletion and cell death in 2 scenarios of C-OGD: the avascular phase and the stem cell niche. CSCs survival to that C-OGD is necessary for tumor perpetuation. We hypothesize that CSCs may be an exception to the WE. Methods: We exposed 106 MDA-MB-231 (Wt) breast cancer cells to 5 weeks C-OGD (0.2%O2 + 0.05g/l G). Fifteen clones (C1-15) survived and were tested vs. Wt for stemness (PNAS 100:3983-8), metabolic features, viability and gene expression (cDNA microarrays) in 4 experimental O2/G settings: 21%/4.5g/L (1); 21%/0.05g/L (2), 0.2%/4.5g/L (3) or 0.2%/0.05g/L (4) Xenografts were grown to compare in vivo features. Gene expression hits were screened as targets. Fisher test/Student T/Partek's Anova were used to compare percentage/group observations/gene expression. All results p < 0.05. Results: Stemness: the stem CD44+/CD24-/CD133+ subpopulation was 50-fold larger in C1-15 vs. Wt cells. C1-15 vs. Wt xenografted successfully in SCID mice using < 100 cells in 75% vs. 12% cases. Metabolism: ATP production decreased 25-fold upon exposure from settings 1 to 4 in Wt but remained constant in C1-15 as they were able to increase O2 consumption and fatty acid oxidation by 200- and 50-fold. Mitochondrial (MITOC) potential and ATP output in presence of GLY/MITOC inhibitors study revealed electron transfer chain as main ATP source for C1-15 and GLY for Wt. Viability: BrdU uptake/colony assays showed a 30-fold decrease in Wt viability from settings 1 to 4; no change in C1-15, explained by the ability to quench the excess of free radicals in settings 2-4. Gene expression top hits to explain C-OGD adaptation (C1-15 vs. Wt) were upregulation of ATP synthase (ATPs; 3.5-fold) and lack of upregulation of Hif-1α and PDK1 (↓2.5-fold). Xenografts from C1-15 vs. Wt showed ≈size, ↑ ATPs, ↓ vessels, ↑hypoxia but ↓necrosis. Screening revealed ATPs as target: stable ATPs shRNA knockdown or oligomycin (ATPs inhibitor) reverted the exposed features. Conclusions: CSCs survive to C-OGD by switching from WE to MITOC metabolism. CSC phenotype can be abrogated by blocking ATPs. No significant financial relationships to disclose.
ABC of clinical electrocardiography: Acute myocardial infarction---Part II
Authors: June Edhouse, William J Brady, Francis Morris
Journal: BMJ (2002)

This article describes the association of bundle branch block with acute myocardial infarction and the differential diagnosis of ST segment elevation.



Appropriate discordance in uncomplicated left bundle branch block (note ST elevation in leads V1 to V3)



Acute myocardial infarction in the presence of bundle branch block carries a much worse prognosis than acute myocardial infarction with normal ventricular conduction. This is true both for patients whose bundle branch block precedes the infarction and for those in whom bundle branch block develops as a result of the acute event. Thrombolytic treatment produces dramatic reductions in mortality in these patients, and the greatest benefits are seen in those treated early. It is therefore essential that the electrocardiographic identification of acute myocardial infarction in patients with bundle branch block is both timely and accurate.

### Left bundle branch block

Left bundle branch block is most commonly seen in patients with coronary artery disease, hypertension, or dilated cardiomyopathy. The left bundle branch usually receives blood from the left anterior descending branch of the left coronary artery and from the right coronary artery. When new left bundle branch block occurs in the context of an acute myocardial infarction the infarct is usually anterior and mortality is extremely high.

The electrocardiographic changes of acute myocardial infarction can be difficult to recognise when left bundle branch block is present, and many of the conventional diagnostic criteria are not applicable.



Acute myocardial infarction and left bundle branch block. Note that the ST segments are elevated in leads V5 and V6 (inappropriate concordance) and grossly elevated (> 5 mm) in leads V2, V3, and V4; note also the ST segment depression in leads III and aVF



Abnormal ventricular depolarisation in left bundle branch block leads to secondary alteration in the recovery process (see …
BCL-2-Selective BH3 Mimetic ABT-199 Is a Potent Agent For Acute Myeloid Leukemia
Authors: Rongqing Pan, LaKeisha Debose, Juliana M Benito, Leonard S Golfman, Patrick A Zweidler-McKay, Lina Han, Karine G. Harutyunyan, Hong Mu, Vivian R Ruvolo, Eugene Park, Markus Muschen, Joel Leverson, Gautam Borthakur, Hagop M Kantarjian, Peter P. Ruvolo, Michael Andreeff, Marina Konopleva
Journal: Blood (2013)