tbuckley/cabot-search huggingface dataset:
Monitoring minimal residual disease in patients with multiple myeloma by targeted tracking serum M-protein using mass spectrometry (EasyM)
Authors: Huishou Fan, Bing Wang, Lihui Shi, Ni Pan, Wenqiang Yan, Jingyu Xu, Lixin Gong, Lingna Li, Yuntong Liu, Chenxing Du, Jian Cui, Guoqing Zhu, Shuhui Deng, Weiwei Sui, Yan Xu, Shuhua Yi, Mu Hao, Dehui Zou, Xiequn Chen, Lugui Qiu, Gang An
Journal: Clinical Cancer Research (2024)

Abstract Purpose: We investigated both the clinical utilities and the prognostic impacts of the clonotypic peptide mass spectrometry (MS)-EasyM, a blood-based minimal residual disease (MRD) monitoring protocol in multiple myeloma. Experimental Design: A total of 447 sequential serum samples from 56 patients with multiple myeloma were analyzed using EasyM. Patient-specific M-protein peptides were sequenced from diagnostic samples; sequential samples were quantified by EasyM to monitor the M-protein. The performance of EasyM was compared with serum immunofixation electrophoresis (IFE), bone marrow multiparameter flow cytometry (MFC), and next-generation flow cytometry (NGF) detection. The optimal balance of EasyM sensitivity/specificity versus NGF (10−5 sensitivity) was determined and the prognostic impact of MS-MRD status was investigated. Results: Of the 447 serum samples detected and measured by EasyM, 397, 126, and 92 had time-matching results for comparison with serum IFE, MFC-MRD, and NGF-MRD, respectively. Using a dotp &amp;gt;0.9 as the MS-MRD positive, sensitivity was 99.6% versus IFE and 100.0% versus MFC and NGF. Using an MS negative cutoff informed by ROC analysis (&amp;lt;1.86% of that at diagnosis), EasyM sensitivity remained high versus IFE (88.3%), MFC (85.1%), and NGF (93.2%), whereas specificity increased to 90.4%, 55.8%, and 93.2%, respectively. In the multivariate analysis, older diagnostic age was an independent predictor for progression-free survival [PFS; high risk (HR), 3.15; 1.26–7.86], the best MS-MRD status (MS-MRD negative) was independent predictor for both PFS (HR, 0.25; 0.12–0.52) and overall survival (HR, 0.16; 0.06–0.40). Conclusions: EasyM is a highly sensitive and minimal invasive method of MRD monitoring in multiple myeloma; MS-MRD had significant predictive ability for survival outcomes.
Computerized cognitive training for memory functions in mild cognitive impairment or dementia: a systematic review and meta-analysis
Authors: Aaron T. C. Chan, Roy T. F. Ip, Joshua Y. S. Tran, Joyce Y. C. Chan, Kelvin K. F. Tsoi
Journal: npj Digital Medicine (2024)

Abstract Dementia is a common medical condition in the ageing population, and cognitive intervention is a non-pharmacologic strategy to improve cognitive functions. This meta-analysis evaluated the benefits of computerized cognitive training (CCT) on memory functions in individuals with MCI or dementia. The study was registered prospectively with PROSPERO under CRD42022363715 and received no funding. The search was conducted on MEDLINE, Embase, and PsycINFO on Sept 19, 2022, and Google Scholar on May 9, 2023, to identify randomized controlled trials that examined the effects of CCT on memory outcomes in individuals with MCI or dementia. Mean differences and standard deviations of neuropsychological assessment scores were extracted to derive standardized mean differences. Our search identified 10,678 studies, of which 35 studies were included. Among 1489 participants with MCI, CCT showed improvements in verbal memory (SMD (95%CI) = 0.55 (0.35–0.74)), visual memory (0.36 (0.12–0.60)), and working memory (0.37 (0.10–0.64)). Supervised CCT showed improvements in verbal memory (0.72 (0.45–0.98)), visual memory (0.51 (0.22–0.79)), and working memory (0.33 (0.01–0.66)). Unsupervised CCT showed improvement in verbal memory (0.21 (0.04–0.38)) only. Among 371 participants with dementia, CCT showed improvement in verbal memory (0.64 (0.02–1.27)) only. Inconsistency due to heterogeneity (as indicated by I 2 values) is observed, which reduces our confidence in MCI outcomes to a moderate level and dementia outcomes to a low level. The results suggest that CCT is efficacious on various memory domains in individuals with MCI. Although the supervised approach showed greater effects, the unsupervised approach can improve verbal memory while allowing users to receive CCT at home without engaging as many healthcare resources.
Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia
Authors: Art Schuermans, Buu Truong, Maddalena Ardissino, Rohan Bhukar, Eric A. W. Slob, Tetsushi Nakao, Jacqueline S. Dron, Aeron M. Small, So Mi Jemma Cho, Zhi Yu, Whitney Hornsby, Tajmara Antoine, Kim Lannery, Darina Postupaka, Kathryn J. Gray, Qi Yan, Adam S. Butterworth, Stephen Burgess, Malissa J. Wood, Nandita S. Scott, Colleen M. Harrington, Amy A. Sarma, Emily S. Lau, Jason D. Roh, James L. Januzzi, Pradeep Natarajan, Michael C. Honigberg
Journal: JAMA Cardiology (2024)

Hypertensive disorders of pregnancy (HDPs), including gestational hypertension and preeclampsia, are important contributors to maternal morbidity and mortality worldwide. In addition, women with HDPs face an elevated long-term risk of cardiovascular disease.
Home-Use Transcranial Direct Current Stimulation for the Treatment of a Major Depressive Episode
Authors: Lucas Borrione, Beatriz A. Cavendish, Luana V. M. Aparicio, Matthias S. Luethi, Stephan Goerigk, Matheus R. F. Ramos, Natasha K. S. Moran, Adriana M. Carneiro, Leandro Valiengo, Darin O. Moura, Juliana P. de Souza, Mariana P. Batista, Valquiria Aparecida da Silva, Izio Klein, Paulo Suen, José Gallucci-Neto, Frank Padberg, Lais B. Razza, Marie-Anne Vanderhasselt, Paulo A. Lotufo, Isabela M. Bensenor, Felipe Fregni, Andre R. Brunoni
Journal: JAMA Psychiatry (2024)

Transcranial direct current stimulation (tDCS) is moderately effective for depression when applied by trained staff. It is not known whether self-applied tDCS, combined or not with a digital psychological intervention, is also effective.
A sprinkle of methotrexate to go with biologics: a safe recipe?
Authors: Oras A Alabas, Zenas Z N Yiu
Journal: British Journal of Dermatology (2024)

Journal Article A sprinkle of methotrexate to go with biologics: a safe recipe? Get access Oras A Alabas, Oras A Alabas Formal analysis, Investigation Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester https://orcid.org/0000-0003-2002-0781 Search for other works by this author on: Oxford Academic Google Scholar Zenas Z N Yiu Zenas Z N Yiu Formal analysis, Investigation Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of ManchesterDermatology Department, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK Correspondence: Zenas Z.N. Yiu. Email: zenas.yiu@manchester.ac.uk https://orcid.org/0000-0002-1831-074X Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 190, Issue 3, March 2024, Pages 302–303, https://doi.org/10.1093/bjd/ljad505 Published: 03 January 2024 Article history Received: 07 December 2023 Accepted: 08 December 2023 Published: 03 January 2024 Corrected and typeset: 29 January 2024
Transverse colon primary tumor location as a biomarker in metastatic colorectal cancer: A pooled analysis of CCTG/AGITG CO.17 and CO.20 randomized clinical trials
Authors: Joao Paulo Solar Vasconcelos, Nan Chen, Emma Titmuss, Dongsheng Tu, Stephanie Y. Brule, Rachel Goodwin, Derek J. Jonker, Timothy Price, John R. Zalcberg, Malcolm J. Moore, Christos S. Karapetis, Lillian Siu, Jeremy Shapiro, John Simes, Sharlene Gill, Chris J. O'Callaghan, Jonathan M. Loree
Journal: Clinical Cancer Research (2024)

Abstract Purpose: Sidedness is prognostic and predictive of anti-EGFR efficacy in metastatic colorectal cancer (mCRC). Transverse colon has been historically excluded from several analyses of sidedness and the optimal division between left- and right-sided colorectal cancer is unclear. We investigated transverse colon primary tumor location as a biomarker in mCRC. Experimental Design: Pooled analysis of CCTG/AGITG CO.17 and CO.20 trials of cetuximab in chemotherapy-refractory mCRC. Outcomes of patients with RAS/BRAF wild-type (WT) mCRC from CO.17 and KRAS WT mCRC from CO.20 were analyzed according to location. Results: A total of 553 patients were analyzed, 32 (5.8%) with cancers from the transverse, 101 (18.3%) from right, and 420 from (75.9%) left colon. Transverse mCRC failed to reach significant benefit from cetuximab versus best supportive care (BSC) for overall survival [OS; median, 5.9 vs. 2.1 months; HR, 0.63; 95% confidence interval (CI), 0.28–1.42; P=0.26] and progression-free survival (PFS; median, 1.8 vs. 1.3 months; HR, 0.57; 95% CI, 0.26–1.28; P=0.16). Analyzing exclusively patients randomized to cetuximab, right-sided and transverse had comparable outcomes for OS (median, 5.6 vs. 5.9 months; HR, 0.82; 95% CI, 0.50–1.34; P=0.43) and PFS (median, 1.9 vs. 1.8 months; HR, 0.78; 95% CI, 0.49–1.26; P=0.31). Patients with left-sided mCRC had superior outcomes with cetuximab compared with transverse for OS (median, 9.7 vs. 5.9 months; HR, 0.42; 95% CI, 0.27–0.67; P=0.0002) and PFS (median, 3.8 vs. 1.8 months; HR, 0,49; 95% CI, 0.31–0.76; P=0.001). Location was not prognostic in patients treated with BSC alone. Conclusions: Transverse mCRC has comparable prognostic and predictive features with right-sided mCRC.
Early Detection of Molecular Residual Disease and Risk Stratification for Children with Acute Myeloid Leukemia via Circulating Tumor DNA
Authors: Li-Peng Liu, Su-Yu Zong, Ao-Li Zhang, Yuan-Yuan Ren, Ben-Quan Qi, Li-Xian Chang, Wen-Yu Yang, Xiao-Juan Chen, Yu-Mei Chen, Li Zhang, Yao Zou, Ye Guo, Ying-Chi Zhang, Min Ruan, Xiao-Fan Zhu
Journal: Clinical Cancer Research (2024)

Abstract Purpose: Patient-tailored minimal residual disease (MRD) monitoring based on circulating tumor DNA (ctDNA) sequencing of leukemia-specific mutations enables early detection of relapse for pre-emptive treatment, but its utilization in pediatric acute myelogenous leukemia (AML) is scarce. Thus, we aim to examine the role of ctDNA as a prognostic biomarker in monitoring response to the treatment of pediatric AML. Experimental Design: A prospective longitudinal study with 50 children with AML was launched, and sequential bone marrow (BM) and matched plasma samples were collected. The concordance of mutations by next-generation sequencing–based BM-DNA and ctDNA was evaluated. In addition, progression-free survival (PFS) and overall survival (OS) were estimated. Results: In 195 sample pairs from 50 patients, the concordance of leukemia-specific mutations between ctDNA and BM-DNA was 92.8%. Patients with undetectable ctDNA were linked to improved OS and PFS versus detectable ctDNA in the last sampling (both P &amp;lt; 0.001). Patients who cleared their ctDNA post three cycles of treatment had similar PFS compared with persistently negative ctDNA (P = 0.728). In addition, patients with &amp;gt;3 log reduction but without clearance in ctDNA were associated with an improved PFS as were patients with ctDNA clearance (P = 0.564). Conclusions: Thus, ctDNA-based MRD monitoring appears to be a promising option to complement the overall assessment of pediatric patients with AML, wherein patients with continuous ctDNA negativity have the option for treatment de-escalation in subsequent therapy. Importantly, patients with &amp;gt;3 log reduction but without clearance in ctDNA may not require an aggressive treatment plan due to improved survival, but this needs further study to delineate.
Single-cell landscape of idiopathic multicentric Castleman disease in identical twins
Authors: Jason Yongsheng Chan, Jui Wan Loh, Jing Quan Lim, Herty Liany, Elizabeth Chun Yong Lee, Jing Yi Lee, Bavani Kannan, Boon Yee Lim, Zexi Guo, Kerry Lim, Jeslin Chian Hung Ha, Cedric Chuan-Young Ng, Tun Kiat Ko, Dachuan Huang, Dominique Yuan Bin Seow, Chee Leong Cheng, Sock Hoai Chan, Joanne Ngeow, Bin Tean Teh, Soon Thye Lim, Choon Kiat Ong
Journal: Blood (2024)

Abstract Idiopathic multicentric Castleman disease (iMCD) is a rare cytokine-driven disorder characterized by systemic inflammation, generalized lymphadenopathy, and organ dysfunction. Here, we present an unusual occurrence of iMCD in identical twins and examined the immune milieu within the affected lymphoid organs and the host circulation using multiomic high-dimensional profiling. Using spatial enhanced resolution omics sequencing (Stereo-seq) transcriptomic profiling, we performed unsupervised spatially constrained clustering to identify different anatomic structures, mapping the follicles and interfollicular regions. After a cell segmentation approach, interleukin 6 (IL-6) pathway genes significantly colocalized with endothelial cells and fibroblastic reticular cells, confirming observations using a single-cell sequencing approach (10× Chromium). Furthermore, single-cell sequencing of peripheral blood mononuclear cells revealed an “inflammatory” peripheral monocytosis enriched for the expression of S100A family genes in both twins. In summary, we provided evidence of the putative cell-of-origin of IL-6 signals in iMCD and described a distinct monocytic host immune response phenotype through a unique identical twin model.
<i>Staphylococcus aureus</i> induces drug resistance in cancer T cells in Sézary syndrome
Authors: Chella Krishna Vadivel, Andreas Willerslev-Olsen, Martin R. J. Namini, Ziao Zeng, Lang Yan, Maria Danielsen, Maria Gluud, Emil M. H. Pallesen, Karolina Wojewoda, Amra Osmancevic, Signe Hedebo, Yun-Tsan Chang, Lise M. Lindahl, Sergei B. Koralov, Larisa J. Geskin, Susan E. Bates, Lars Iversen, Thomas Litman, Rikke Bech, Marion Wobser, Emmanuella Guenova, Maria R. Kamstrup, Niels Ødum, Terkild B. Buus
Journal: Blood (2024)

Patients with Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), are prone to Staphylococcus aureus infections and have a poor prognosis due to treatment resistance. Here, we report that S aureus and staphylococcal enterotoxins (SE) induce drug resistance in malignant T cells against therapeutics commonly used in CTCL. Supernatant from patient-derived, SE-producing S aureus and recombinant SE significantly inhibit cell death induced by histone deacetylase (HDAC) inhibitor romidepsin in primary malignant T cells from patients with SS. Bacterial killing by engineered, bacteriophage-derived, S aureus-specific endolysin (XZ.700) abrogates the effect of S aureus supernatant. Similarly, mutations in major histocompatibility complex (MHC) class II binding sites of SE type A (SEA) and anti-SEA antibody block induction of resistance. Importantly, SE also triggers resistance to other HDAC inhibitors (vorinostat and resminostat) and chemotherapeutic drugs (doxorubicin and etoposide). Multimodal single-cell sequencing indicates T-cell receptor (TCR), NF-κB, and JAK/STAT signaling pathways (previously associated with drug resistance) as putative mediators of SE-induced drug resistance. In support, inhibition of TCR-signaling and Protein kinase C (upstream of NF-κB) counteracts SE-induced rescue from drug-induced cell death. Inversely, SE cannot rescue from cell death induced by the proteasome/NF-κB inhibitor bortezomib. Inhibition of JAK/STAT only blocks rescue in patients whose malignant T-cell survival is dependent on SE-induced cytokines, suggesting 2 distinct ways SE can induce drug resistance. In conclusion, we show that S aureus enterotoxins induce drug resistance in primary malignant T cells. These findings suggest that S aureus enterotoxins cause clinical treatment resistance in patients with SS, and antibacterial measures may improve the outcome of cancer-directed therapy in patients harboring S aureus.
Hydroxyurea reduces infections in children with sickle cell anemia in Uganda
Authors: Ruth Namazzi, Caitlin Bond, Andrea L. Conroy, Dibyadyuti Datta, Abner Tagoola, Michael J. Goings, Jeong Hoon Jang, Russell E. Ware, Robert Opoka, Chandy C. John
Journal: Blood (2024)

After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001).
Long-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with delirium
Authors: Camilla Bekker Mortensen, Nina Christine Andersen-Ranberg, Lone Musaeus Poulsen, Anders Granholm, Bodil Steen Rasmussen, Maj-Brit Nørregaard Kjær, Theis Lange, Bjørn H. Ebdrup, Marie Oxenbøll Collet, Anne Sofie Andreasen, Morten Heiberg Bestle, Bülent Uslu, Helle Scharling Pedersen, Louise Gramstrup Nielsen, Johanna Hästbacka, Troels Bek Jensen, Kjeld Damgaard, Trine Sommer, Matthew Morgen, Nilanjan Dey, Guiseppe Citerio, Stine Estrup, Ingrid Egerod, Karin Samuelson, Anders Perner, Ole Mathiesen
Journal: Intensive Care Medicine (2024)

We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo.
Automated Segmentation of Ablated Lesions Using Deep Convolutional Neural Networks: A Basis for Response Assessment Following Laser Interstitial Thermal Therapy
Authors: Aden P Haskell-Mendoza, Ellery H Reason, Ariel T Gonzalez, Joshua D Jackson, Eric W Sankey, Ethan S Srinivasan, James E Herndon, Peter E Fecci, Evan Calabrese
Journal: Neuro-Oncology (2024)

Abstract Background Laser interstitial thermal therapy (LITT) of intracranial tumors or radiation necrosis enables tissue diagnosis, cytoreduction, and rapid return to systemic therapies. Ablated tissue remains in situ, resulting in characteristic post-LITT edema associated with transient clinical worsening and complicating post-LITT response assessment. Methods All patients receiving LITT at a single center for tumors or radiation necrosis from 2015 to 2023 with ≥9 months of MRI follow-up were included. An nnU-Net segmentation model was trained to automatically segment contrast-enhancing lesion volume (CeLV) of LITT-treated lesions on T1-weighted images. Response assessment was performed using volumetric measurements. Results Three hundred and eighty four unique MRI exams of 61 LITT-treated lesions and 6 control cases of medically managed radiation necrosis were analyzed. Automated segmentation was accurate in 367/384 (95.6%) images. CeLV increased to a median of 68.3% (IQR 35.1–109.2%) from baseline at 1–3 months from LITT (P = 0.0012) and returned to baseline thereafter. Overall survival (OS) for LITT-treated patients was 39.1 (9.2–93.4) months. Lesion expansion above 40% from volumetric nadir or baseline was considered volumetric progression. Twenty-one of 56 (37.5%) patients experienced progression for a volumetric progression-free survival of 21.4 (6.0–93.4) months. Patients with volumetric progression had worse OS (17.3 vs 62.1 months, P = 0.0015). Conclusions Post-LITT CeLV expansion is quantifiable and resolves within 6 months of LITT. Development of response assessment criteria for LITT-treated lesions is feasible and should be considered for clinical trials. Automated lesion segmentation could speed the adoption of volumetric response criteria in clinical practice.
The logic of recurrent circuits in the primary visual cortex
Authors: Ian Antón Oldenburg, William D Hendricks, Gregory Handy, Kiarash Shamardani, Hayley A Bounds, Brent Doiron, Hillel Adesnik
Journal: Nature Neuroscience (2024)

Abstract Recurrent cortical activity sculpts visual perception by refining, amplifying or suppressing visual input. However, the rules that govern the influence of recurrent activity remain enigmatic. We used ensemble-specific two-photon optogenetics in the mouse visual cortex to isolate the impact of recurrent activity from external visual input. We found that the spatial arrangement and the visual feature preference of the stimulated ensemble and the neighboring neurons jointly determine the net effect of recurrent activity. Photoactivation of these ensembles drives suppression in all cells beyond 30 µm but uniformly drives activation in closer similarly tuned cells. In nonsimilarly tuned cells, compact, cotuned ensembles drive net suppression, while diffuse, cotuned ensembles drive activation. Computational modeling suggests that highly local recurrent excitatory connectivity and selective convergence onto inhibitory neurons explain these effects. Our findings reveal a straightforward logic in which space and feature preference of cortical ensembles determine their impact on local recurrent activity.
PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy
Authors: Daniel Davies, Shraddha Kamdar, Richard Woolf, Iva Zlatareva, Maria Luisa Iannitto, Cienne Morton, Yasmin Haque, Hannah Martin, Dhruva Biswas, Susan Ndagire, Martina Munonyara, Cheryl Gillett, Olga O'Neill, Oliver Nussbaumer, Adrian Hayday, Yin Wu
Journal: Nature Cancer (2024)

Abstract Checkpoint inhibition (CPI), particularly that targeting the inhibitory coreceptor programmed cell death protein 1 (PD-1), has transformed oncology. Although CPI can derepress cancer (neo)antigen-specific αβ T cells that ordinarily show PD-1-dependent exhaustion, it can also be efficacious against cancers evading αβ T cell recognition. In such settings, γδ T cells have been implicated, but the functional relevance of PD-1 expression by these cells is unclear. Here we demonstrate that intratumoral TRDV1 transcripts (encoding the TCRδ chain of Vδ1 + γδ T cells) predict anti-PD-1 CPI response in patients with melanoma, particularly those harboring below average neoantigens. Moreover, using a protocol yielding substantial numbers of tissue-derived Vδ1 + cells, we show that PD-1 + Vδ1 + cells display a transcriptomic program similar to, but distinct from, the canonical exhaustion program of colocated PD-1 + CD8 + αβ T cells. In particular, PD-1 + Vδ1 + cells retained effector responses to TCR signaling that were inhibitable by PD-1 engagement and derepressed by CPI.
CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis
Authors: Jian-Jun Lv, Hao Wang, Cong Zhang, Tian-Jiao Zhang, Hao-Lin Wei, Ze-Kun Liu, Yi-Hui Ma, Zhi Yang, Qian He, Li-Juan Wang, Li-Li Duan, Zhi-Nan Chen, Huijie Bian
Journal: Circulation Research (2024)

Atherosclerosis is a globally prevalent chronic inflammatory disease with high morbidity and mortality. The development of atherosclerotic lesions is determined by macrophages. This study aimed to investigate the specific role of myeloid-derived CD147 (cluster of differentiation 147) in atherosclerosis and its translational significance.
How to interpret the EURO-SKI study and its treatment-free remission outcome. Reply to R.P. Gale and J. Chen
Authors: Markus Pfirrmann, Susanne Saussele, François-Xavier Mahon, Johan Richter
Journal: Leukemia (2024)

Recently, Gale and Chen published their perspective on "How should we interpret conclusions of TKI-stopping studies" [1].The authors focused on the EURO-SKI trial as the largest study on treatment-free remission (TFR) after stopping a tyrosine kinase inhibitor (TKI), claimed the study to be biased, and criticised outcome interpretation.We explain why their allegation of bias is unjustified and clarify the interpretation of the trial.
Amino acid intake strategies define pluripotent cell states
Authors: Pavlina K Todorova, Benjamin T Jackson, Vidur Garg, Katrina I Paras, Julia S Brunner, Anna E Bridgeman, Yanyang Chen, Sanjeethan C Baksh, Jielin Yan, Anna-Katerina Hadjantonakis, Lydia W S Finley
Journal: Nature Metabolism (2024)
An African One Health network for antimicrobial resistance and neglected tropical diseases
Authors: Ahmed Abd El Wahed, Paul Kadetz, Julius Boniface Okuni, Yakhya Dieye, Michael Frimpong, George Olusegun Ademowo, Sheila Makiala-Mandanda, Yimtubezinash Woldeamanuel, Kamal Hassan Eltom, Georgina Yeboah, Annemarie Käsbohrer, Henry Kajumbula, Uwe Truyen, Damalie Nakanjako
Journal: Nature Medicine (2024)