THE TREATMENT OF LIVER DISEASE
Authors: Albert M. Snell
Journal: Annals of Internal Medicine (1938)

Article1 November 1938THE TREATMENT OF LIVER DISEASEALBERT M. SNELL, M.D., F.A.C.P.ALBERT M. SNELL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-5-592 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAttempts at treatment of parenchymatous disease of the liver other than those types which are entirely self-limited constitute a somewhat discouraging chapter in medical history. Most therapeutic procedures have been used, discarded, and readopted at intervals over a period of many years and all have failed so signally to cure or control such diseases that the present generally pessimistic attitude in regard to therapeusis is well justified. However, within recent years a great deal of valuable experimental work has been done on the pathologic physiology of the liver, indicating the tremendous reserve function of the organ and its capacity...References1. BOYCEVEALMCFETRIDGE FFJREM: An analysis of the mortality of gall-bladder surgery: with a special note on the so-called liver death: based on 404 consecutive surgical cases and 100 consecutive surgical deaths in the New Orleans Charity Hospital, Surg., Gynec. and Obst., 1936, lxiii, 43-53. Google Scholar2. LEGG W: On cirrhosis of the liver, St. Bartholomew's Hosp. Rep., 1872, viii, 74-83. Google Scholar3. MANNFISHBACKGAYGREENE FCFCJGGF: Experimental pathology of the liver. Studies III, IV, and V, Arch. Pathol., 1931, xii, 787-793. Google Scholar4. OPIEALFORD ELLB: The influence of diet upon necrosis caused by hepatic and renal poisons. Part 1. Diet and the hepatic lesions of chloroform, phosphorus or alcohol, Jr. Exper. Med., 1915, xxi, 1-20. CrossrefGoogle Scholar5. GREAVESSCHMIDT JDCL: The nature of the factor concerned in loss of blood coagulability of bile fistula rats, Proc. Soc. Exper. Biol. and Med., 1937, xxxvii, 43-45. CrossrefGoogle Scholar6. GREAVESSCHMIDT JDCL: Relation of bile to absorption of vitamin E in the rat, Proc. Soc. Exper. Biol. and Med., 1937, xxxvii, 40-42. CrossrefGoogle Scholar7. HEYMANN W: Importance of the liver for the antirachitic efficacy of vitamin D, Proc. Soc. Exper. Biol. and Med., 1937, xxxvi, 812-814. CrossrefGoogle Scholar8. EPPINGER H: Die Leberkrankheiten; allgemeine und spezielle Pathologie und Therapie der Leber, 1937, Julius Springer, Vienna, 801 pp. Google Scholar9. ALLANBOWIEMACLEODROBINSON FNDJJJWL: Behaviour of depancreatized dogs kept alive with insulin, Brit. Jr. Exper. Pathol., 1924, v, 75-83. Google Scholar10. BESTHERSHEY CHJM: Further observations on the effects of some component of crude lecithine on depancreatized animals, Jr. Physiol., 1932, lxxv, 49-55. CrossrefGoogle Scholar11. BESTFERGUSONHERSHEY CHGCJM: Choline and liver fat in diabetic dogs, Jr. Physiol., 1933, lxxix, 94-102. CrossrefGoogle Scholar12. DRAGSTEDTVAN PROHASKAHARMS LRJHP: Observations on a substance in pancreas (a fat metabolizing hormone) which permits survival and prevents liver changes in depancreatized dogs, Am. Jr. Physiol., 1936, cxvii, 175-181. CrossrefGoogle Scholar13. SNELLCOMFORT AMMW: Hepatic lesions presumably secondary to pancreatic lithiasis and atrophy; report of two cases, Am. Jr. Digest. Dis. and Nutr., 1937, iv, 215-218. CrossrefGoogle Scholar14. NEALE RC: The protective action of certain purines against liver necrosis produced by carbon tetrachloride and chloroform, Science, 1937, lxxxvi, 83-84. CrossrefGoogle Scholar15. NEALEWINTER RCHC: The identification of the active crystalline substance from liver which protects against liver damage due to chloroform or carbon tetrachloride; and a study of related compounds, Jr. Pharmacol. and Exper. Therap., 1938, lxii, 127-148. Google Scholar16. FORBESNEALE JCRC: A new preparation protecting against rat liver necrosis, Proc. Soc. Exper. Biol. and Med., 1936, xxxiv, 319-322. CrossrefGoogle Scholar17. FORBESMCCONNELL JCJS: Crystallization of liver fraction protecting against necrosis from carbon tetrachloride or chloroform administration, Proc. Soc. Exper. Biol. and Med., 1937, xxxvi, 359-360. CrossrefGoogle Scholar18. EPSTEINGREENSPAN EZEB: Clinical significance of the cholesterol partition of the blood plasma in hepatic and in biliary diseases, Arch. Int. Med., 1936, lviii, 860-890. CrossrefGoogle Scholar19. BOLLMANMANN JLFC: The physiology of the impaired liver, Ergebn. d. Physiol., 1936, xxxviii, 445-492. CrossrefGoogle Scholar20. SOFFERDANTESSOBOTKA LJDAH: Electrolytes of blood and urine of dogs with acute hepatic injury produced by arsphenamine, Arch. Int. Med., 1937, lx, 509-521. CrossrefGoogle Scholar21. BECKMANN K: Leber und Mineralhaushalt, Klin. Wchnschr., 1930, ix, 49-51. CrossrefGoogle Scholar22. PICK EP: Wasser- und Mineralstoffwechsel in ihren Beziehungen zu Verdauungs-und Stoffwechselkrankheiten, Verhandl. d. Gesellsch. f. Verdauungs- u. Stoffwechselkrankh., 1925-1926, v-vi, 125-136. Google Scholar23. SNELLROTH AMGM: The lactic acid of the blood in hepatic disease, Jr. Clin. Invest., 1932, xi, 957-971. CrossrefGoogle Scholar24. GAUTIERCHATRONSEIDMANN CMP: Intoxication par le tétrachlorure de carbone; hyperazotémie élévee, effondrement de la resérve alcaline, hypochlorémie considérable. Alcalinisation et rechloruration, Bull. et. mém. Soc. méd. d. hôp. de Par., 1933, xlix, 1638-1650. Google Scholar25. SNELLMACLAY AME: The effects of chronic diseases of the liver on the composition and physicochemical properties of blood; changes in the serum proteins; reduction in the oxygen saturation of arterial blood, ANN. INT. MED., 1935, ix, 690-711. Google Scholar26. MCMICHAEL J: The oxygen supply of the liver, Quart. Jr. Exper. Physiol., 1937, xxvii, 73-87. CrossrefGoogle Scholar27. CAMPBELL JA: Concerning the problem of Mount Everest, Lancet, 1928, ii, 84-86. CrossrefGoogle Scholar28. ROSIN A: Morphologische Organveränderungen beim Leben unter Luftverdünnung, Beitr. z. path. Anat. u. z. allg. Path., 1928, lxxx, 622-639. Google Scholar29. KEYSSNELL AAM: Respiratory properties of arterial blood in normal man and in patients with disease of the liver: position of the oxygen dissociation curve, Jr. Clin. Invest., 1938, xvii, 59-67. CrossrefGoogle Scholar30. ALTHAUSENSTOCKHOLM TAM: Deposition of glycogen in normal and in experimentally damaged livers after oral and intravenous administration of dextrose, Trans. Am. Gastro-Enterol. Assoc., pp. 106-110, 1937. Google Scholar31. JONES CM: The treatment of acute hepatic insufficiency and its relation to prognosis, Am. Jr. Digest. Dis. and Nutr., 1936, iii, 624-629. CrossrefGoogle Scholar32. HARROPTHORN GAGW: Studies on the suprarenal cortex. VI. The effect of suprarenal cortical hormone upon the electrolyte excretion of the normal intact dog. A proposed method of comparative assay, Jr. Exper. Med., 1937, lxv, 757-766. CrossrefGoogle Scholar33. THORN GW: Effect of adrenal cortical hormone on renal excretion of electrolytes in normal subjects, Proc. Soc. Exper. Biol. and Med., 1937, xxxvi, 361-364. CrossrefGoogle Scholar34. JUDDSNELLHOERNER ESAMMT: Transfusion for jaundiced patients, Jr. Am. Med. Assoc., 1935, cv, 1653-1658. CrossrefGoogle Scholar35. THOMPSONCAUGHEYWHIPPLEROUSSELOT WPJLAOLM: Splenic vein pressure in congestive splenomegaly (Banti's syndrome), Jr. Clin. Invest., 1937, xvi, 571-572. CrossrefGoogle Scholar36. MCINDOE AH: The vascular lesions of portal cirrhosis, Arch. Pathol. and Lab. Med., 1928, v, 23-42. Google Scholar37. MYERSKEEFER WKCS: Relation of plasma proteins to ascites and edema in cirrhosis of the liver, Arch. Int. Med., 1935, lv, 349-359. CrossrefGoogle Scholar38. BUTTKEYS HRA: Colloid osmotic pressure: studies of normal individuals and of those with hypoproteinemia, Proc. Staff Meet. Mayo Clinic, 1937, xii, 566-571. Google Scholar39. BOLLMAN JL: Unpublished data. Google Scholar40. SZENT-GYÖRGYI A: Verhandl. d. Gesellsch. f. Verdauungs- u. Stoffwechselkrankh., 1934, xii, 49-57. Google Scholar41. HÖPFNER E: Der Aszites und seine chirurgische Behandlung, Ergebn. d. Chir. u. Orthop., 1913, vi, 410-480. CrossrefGoogle Scholar42. HUGHSON W: Portal cirrhosis with ascites and its surgical treatment, Arch. Surg., 1927, xv, 418-440. CrossrefGoogle Scholar43. ELIOTCOLP ER: The operation of omentopexy in cirrhosis of the liver, Surg., Gynec. and Obst., 1919, xxviii, 309-315. Google Scholar44. FULLERCOOKMACKENZIEZBITNOFF MKDDWON: Enterectomy in the surgical treatment of hepatic cirrhosis or portal obstruction with ascites, Surg., Gynec. and Obst., 1937, lxv, 331-335. Google Scholar45. CENTURION : Personal communication to the author. Google Scholar46. MILLER RT: The surgical treatment of ascites. Direct drainage of the fluid into the blood stream by implantation of the saphenous vein in the peritoneum; report of five cases, Pennsylvania Med. Jr., 1915, xix, 413-420. Google Scholar47. KERKHOF AC: Plasma colloid osmotic pressure as a factor in edema formation and edema absorption, ANN. INT. MED., 1937, xi, 867-881. Google Scholar48. BUTTKEYS HRA: Osmometric study of gum acacia solutions used for intravenous injection, Jr. Phys. Chem., 1938, xlii, 21-27. CrossrefGoogle Scholar49. FIELD H: The relation of vitamin B to serum proteins and to edema, Jr. Clin. Invest., 1937, xvi, 663-664. Google Scholar50. PATEK AJ: Treatment of alcoholic cirrhosis of the liver with high vitamin therapy, Proc. Soc. Exper. Biol. and Med., 1937, xxxvii, 329-330. CrossrefGoogle Scholar51. ALT HL: The metabolism in pernicious anemia, Arch. Int. Med., 1929, xliii, 488-503. CrossrefGoogle Scholar52. HEATHTAYLOR CWFH: The nitrogen metabolism in anemia during the regeneration of blood, Jr. Clin. Invest., 1936, xv, 411-418. CrossrefGoogle Scholar53. ELMAN R: Intravenous injection of aminoacids in regeneration of serum protein following severe experimental hemorrhage, Proc. Soc. Exper. Biol. and Med., 1937, xxxvi, 867-870. CrossrefGoogle Scholar54. ELMAN R: Urinary output of nitrogen as influenced by intravenous injection of a mixture of amino-acids, Proc. Soc. Exper. Biol. and Med., 1938, xxxvii, 610-613. CrossrefGoogle Scholar55. OSLER W: Recovery in cirrhosis of the liver, Med. News, Philadelphia, 1888, lii, 47. Google Scholar56. OSLER W: Is cirrhosis of the liver curable? Med. News, Philadelphia, 1886, xlix, 327. Google Scholar57. WHITE WH: The cause and prognosis of ascites due to alcoholic cirrhosis of the liver, to perihepatitis, and to chronic peritonitis, Guy's Hospital Rep., 1892, xxxiv, 1-42. Google Scholar58. FELLINGERKLIMA KR: Untersuchungen über Anämien bei Leberzirrhosen, Wien. klin. Wchnschr., 1933, xlvi, 1191-1194. Google Scholar59. GOLDHAMERISAACSSTURGIS SMRCC: The rôle of the liver in hematopoiesis, Am. Jr. Med. Sci., 1934, clxxxviii, 193-199. CrossrefGoogle Scholar60. ROWNTREEWALTERSMCINDOE LGWAH: End results of tying off the coronary vein for the prevention of hemorrhage from esophageal varices, Proc. Staff Meet. Mayo Clinic, 1929, iv, 263-264. Google Scholar61. NAFFZIGERCARRFOOTE HCJLFS: Obstructive jaundice: the cause and prevention of the bleeding dyscrasia, Ann. Surg., 1937, cvi, 745-751. CrossrefGoogle Scholar62. QUICK AJ: The coagulation defect in sweet clover disease and in the hemorrhagic chick disease of dietary origin: a consideration of the source of prothrombin, Am. Jr. Physiol., 1937, cxviii, 260-271. CrossrefGoogle Scholar63. HAWKINSBRINKHOUS WBKM: Prothrombin deficiency the cause of bleeding in bile fistula dogs, Jr. Exper. Med., 1936, lxiii, 795-801. CrossrefGoogle Scholar64. DAM H: Haemorrhages in chicks reared on artificial diets: a new deficiency disease, Nature, 1934, cxxxiii, 909-910. CrossrefGoogle Scholar65. DAM H: The antihaemorrhagic vitamin of the chick; occurrence and chemical nature, Nature, 1935, cxxxv, 652-653. CrossrefGoogle Scholar66. DAM H: The antihaemorrhagic vitamin of the chick, Biochem. Jr., 1935, xxix, 1273-1285. CrossrefGoogle Scholar67. DAMSCHØNHEYDERLIESE HFL: The requirement for vitamin K of some different species of animals, Biochem. Jr., 1937, xxxi, 22-27. CrossrefGoogle Scholar68. DAMSCHØNHEYDERTAGE-HANSEN HFE: Studies on the mode of action of vitamin K, Biochem. Jr., 1936, xxx, 1075-1079. CrossrefGoogle Scholar69. RODERICK LM: A problem in the coagulation of the blood: sweet clover disease of cattle, Am. Jr. Physiol., 1931, xcvi, 413-425. CrossrefGoogle Scholar70. RODERICK LM: The pathology of sweet clover disease in cattle, Jr. Am. Vet. Med. Assoc., 1929, lxxiv, 314-325. Google Scholar71. WARNERBRINKHOUSSMITH EDKMHP: Bleeding tendency of obstructive jaundice: prothrombin deficiency and dietary factors, Proc. Soc. Exper. Biol. and Med., 1938, xxxvii, 628-630. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Presented on the Program of Afternoon Lectures, American College of Physicians, New York, New York, April 5, 1938. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byErnährungstherapieErnährungstherapieA creed for the treatment of diabetesVitamins KAbstracts 1 November 1938Volume 12, Issue 5Page: 592-608KeywordsLiverLiver diseases Issue Published: 1 November 1938 PDF downloadLoading ...