tbuckley/cabot-search huggingface dataset:
Cause and Prevention of Beriberi.
Authors: W. Leonard Braddon
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Can lipophilic statins affect Her2/neu expression in breast cancer?
Authors: S. Gupta, A. Desai
Journal: Journal of Clinical Oncology (2008)

1521 Background: Growing evidence suggests the chemopreventive potential of statins against breast cancer, primarily based on preclinical studies. Lipophilic statins, particularly fluvastatin, have recently been shown in vitro to potentiate the cytotoxic effect of trastuzumab on Her2/neu positive breast cancer cells. However, no clinical studies have explored the relationship between lipophilic statin use and Her2/neu expression in breast cancer till date. We therefore performed a study to determine whether lipophilic statin use in breast cancer patients prior to diagnosis is related to the development of specific Her2/neu type (negative or positive) tumor compared to statin non- users. Methods: A retrospective cohort analysis of 363 female patients from the Albert Einstein Tumor Registry, presenting with breast cancer between January 1, 2004 and June 30, 2006 was done. The main outcome measured was the Her2/neu status of tumors in lipophilic statin users versus non-users, controlling for race, menopausal status, family history of breast cancer, and prior exogenous estrogen use. Results: Pre-diagnosis use of lipophilic statins (lovastatin, simvastatin, atorvastatin) (n=84) and Her2/neu positive status (n=58) was recorded. Controlling for prior estrogen use, menopausal status, family history and race in a multivariate logistic regression, patients using lipophilic statins for at least one year before diagnosis were found to have no significant difference in the development of Her2/neu positive breast cancers than non-users (p=0.908, odds ratio=1.042, 95%CI= 0.52 to 2.09). Conclusions: Her2/neu positive breast cancers are more aggressive than negative sub-types, and less responsive to hormonal treatments. Preclinical data have shown the potentiating effect of statins on trastuzumab-induced killing of Her2/neu positive cancer cells. Our study shows no independent effect of statins on Her2/neu expression in breast cancer. The relationship between lipophilic statin use and Her2/neu expression, however, warrants further investigation by prospective studies, as their combination with trastuzumab may be attractive for clinical development due to the incomplete effect of trastuzumab in Her2/neu positive tumors as a single agent. No significant financial relationships to disclose.
Abstract 1060: Readmission Rates Among Patients With Non-ST-Segment Elevation Myocardial Infarction: Results in 38,131 Patients From the CRUSADE Quality Improvement Initiative
Authors: Tracy Y Wang, Anita Y Chen, Bimal R Shah, Matthew T Roe, Karen P Alexander, E. Magnus Ohman, W. Brian Gibler, Eric D Peterson
Journal: Circulation (2009)
Medical Axioms, Aphorisms and Clinical Memoranda.
Authors: James Alexander Lindsay
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Internal Derangements of the Knee-Joint: Their Pathology and Treatment by Modern Methods.
Authors: Alfred George Timbrell Fisher
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early Mixed T-Cell Chimerism After Allogeneic Hematopoietic Stem Cells Transplantation Is Highly Predictive For Progression Free Survival
Authors: Jérôme Cornillon, Lena Absi, Aurélie Bourmaud, Micha Srour, Fabien Tinquaut, Emmanuelle Tavernier, Denis Guyotat
Journal: Blood (2013)
L'artériectomie dans les artérites oblitérantes: Étude expérimentale et thérapeutique
Authors: René Leriche, Pierre Stricker
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of resistant lung cancer malignant pleural effusion by intrapleural gene therapy
Authors: K. Zarogoulidis, T. Kontakiotis, A. Papagiannis, A. Xafenias, A. Kortsaris
Journal: Journal of Clinical Oncology (2004)

3168 Background: Cytosine deaminase, transferred into tumour cells by an adenovirus vector, can convert the antifungal drug flucytosine to the antimetabolite 5-fluorouracil, which kills not only the transfected tumour cells but also their neighbours by the so-called ‘bystander’ effect. We used this technique in the management of lung cancer patients with malignant pleural effusion Methods: We used this technique in the management of six lung cancer patients with malignant pleural effusion, confirmed either histologically or pathologically. Two patients suffered from small cell lung cancer, which had relapsed after completion of initial chemotherapy, and four patients from adenocarcinoma of the lung that had progressed during chemotherapy procedure. The pleural fluid was drained through intercostal tube, and the treatment procedure was performed when the daily fluid production was less than 200 ml. A total amount of 1012 pfu of adenovirus vector was instilled into the pleural cavity either in a single dose (in four patients) or in two fractions (in two patients, given on the 1st and 7th day). All patients received flucytosine (Ancotil - Roche) 500 mg qds for 14 days Results: In two of the six patients reaccumulation of the fluid stopped within two weeks (one with an adenocarcinoma and the other with SCLC -treatment only by AdCD) and the drain was removed. These two patients died (after 3 and 22 months respectively) because of disease progression without evidence of pleural effusion. The main constitutional toxicity in all patients was fever due to the AdCD. Three patients experienced grade 3 neutropenia due to the concurrently given chemotherapy Conclusions: Intrapleural gene therapy may be a useful adjunct to chemotherapy in the management of refractory pleural effusions associated with lung cancer. No significant financial relationships to disclose.
Double-blind trial of imipramine in Alzheimer's disease patients with and without depression
Authors: B V Reifler, L Teri, M Raskind, R Veith, R Barnes, E White, P McLean
Journal: American Journal of Psychiatry (1989)

The authors divided 61 subjects with primary degenerative dementia of the Alzheimer's type into a group who also met DSM-III criteria for depression (N = 28) and a group who did not (N = 33). Both groups were randomly assigned to an 8-week double-blind trial of imipramine or placebo. Scores on the Hamilton Rating Scale for Depression, administered at baseline and weeks 2, 4, 6, and 8, indicated significant improvement in both groups. Two measures of cognitive function yielded differing results. The results suggest that moderate depression is a treatable condition in patients with Alzheimer's disease.
Abstract 14849: Incremental Prognostic Value of Coronary CT Angiography over Coronary Calcium Score in Symptomatic Patients with Suspected Coronary Disease: Results from the CONFIRM Registry (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry)
Authors: Mouaz Al-Mallah, Stephan Achenbach, Daniel Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J Chow, Augustin Delago, Allison Dunning, Millie J Gomez, Martin Hadamitzky, Joerg Hausleiter, Ronald P Karlsberg, Philipp Kaufmann, Fay Y Lin, Erica Maffei, James K Min, Gilbert Raff, Leslee J Shaw, Todd C Villines, Victor Y Cheng
Journal: Circulation (2011)

Background: While the prognostic value of coronary calcium scoring (CCS) has been well established in asymptomatic individuals, it is also commonly performed at the time of coronary computed tomogr...
Blood Loss Associated with Uncemented Total Hip Replacement: Hypotension Does not Affect Blood Loss
Authors: F W Wittmann
Journal: Journal of the Royal Society of Medicine (1987)

Twenty-seven patients who were moderately hypotensive during uncemented total hip replacement were compared with a group of normotensive patients. There was no statistical difference (P &lt; 0.05) in blood loss measured at time of operation, following operation or in the calculated loss. Hypotension, which is known to be dangerous in the elderly, conferred no benefit and should be avoided.
Public Health Surveys. What They Are, How to Make Them, How to Use Them.
Authors: Murray Philip Horwood
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Endocrine Genetic Signal Between Blood Cells and Vascular Smooth Muscle Cells
Authors: Zhen Shan, Shanshan Qin, Wen Li, Weibin Wu, Jian Yang, Maoping Chu, Xiaokun Li, Yuqing Huo, Gary L. Schaer, Shenming Wang, Chunxiang Zhang
Journal: Journal of the American College of Cardiology (2015)
Abstract 20861: B-type Natriuretic Peptide and C-Reactive Protein as Markers of Coronary Atherosclerosis
Authors: Dipak Kotecha, Marcus Flather, Gishel New, Henry Krum, David Eccleston
Journal: Circulation (2010)

Purpose: The use of high-sensitivity C-reactive protein (CRP) and B-type natriuretic peptide (BNP) as risk markers of coronary atherosclerosis are uncertain in patients with prior coronary artery d...
Abstract 4267: PA32520 (Single-Tablet of Enteric-Coated Aspirin 325 mg + Immediate-Release Omeprazole 20 mg): Aspirin Therapy Combining Greater Thromboxane Suppression and Lower Upper Gastrointestinal Damage
Authors: Paul A Gurbel, John G Fort, Eric Orlemans, John Plachetka
Journal: Circulation (2008)
Childhood Asthma
Authors: Ann R. Punnoose, Alison E. Burke, Robert M. Golub
Journal: JAMA (2012)

Childhood AsthmaA sthma is one of the most common chronic illnesses in children.It occurs when small air passages in the lungs easily get inflamed and overreact to allergens and respiratory viral infections.When the muscles in the walls of the small air passages are stimulated by environmental allergens or infections, they release inflammatory agents that result in narrowing of the airways (bronchoconstriction).This obstructs airflow and leads to the symptoms of asthma.The January 25, 2012, issue of JAMA includes an article on the treatment of children with asthma.
Abstract 1912: Time Course of Change in Plaque Composition Associated with Rosuvastatin Therapy as Assessed by High-Resolution Magnetic Resonance Imaging
Authors: Minako Oikawa, Chun Yuan, Hunter Underhill, Xue-Qiao Zhao, Larry W Kraiss, Dennis L Parker, Tobias Saam, Baocheng Chu, Norihide Takaya, Fei Liu, Nayak L Polissar, Blazej Neradilek, Joel S Raichlen, Valerie A Cain, John C Waterton, Wendy Hamar, Thomas S Hatsukami
Journal: Circulation (2007)

Background: MRI studies of the natural history of carotid atherosclerosis show a slow but significant progression in mean vessel wall area (2.2%/yr; p<.005) and lipid-rich necrotic core (LRNC) size...
Protease-mediated remodelling of the elastic fibre system of intrinsically aged skin
Authors: A K Langton, R E Watson, L F Cotterell, C E Griffiths, M J Sherratt
Journal: British Journal of Dermatology (2010)

Annual Meeting of the British-Society-for-Investigative-Dermatology APR 12-14, 2010 Edinburgh, SCOTLAND
Drug Abuse in Pregnancy and Neonatal Effects.
Authors: José Luis Rementería
Journal: Annals of Internal Medicine (1978)

authors report that menopausal women with os- teoporosis show a greater oestrogen deficiency, especially when treated with corticosteroids.They also show a marked reduction in the plasma testosterone level.These findings give support to my suggestion (Lancet, 1964, ii, 257) that patients under long- term corticosteroid treatment should be given implants of sex hormones (oestradiol and testos- terone) to prevent side effects like osteoporosis and capillary bleeding.
Erkrankungen des Rectum und Sigmoideum: Pathologie, Diagnostik, Verlauf, und klinische Therapie.
Authors: H. Strauss
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of response criteria for mesothelioma based on a mathematical model
Authors: G. R. Oxnard, S. G. Armato, R. Salgia, H. L. Kindler
Journal: Journal of Clinical Oncology (2005)

7176 Background: The pleural rind of malignant mesothelioma (MM) has a unique morphology that is difficult to measure. Active chemotherapy agents are being developed for this disease, requiring consistent measurement standards for evaluation of therapeutic efficacy. The Response Evaluation Criteria in Solid Tumors (RECIST) guidelines, developed based on spherical tumors, require measurement of maximum tumor diameter; in MM, this dimension tends to span the thoracic cavity. The Byrne measurement technique (Ann Oncol 2004), in contrast, proposes measurement of MM thickness, the dimension perpendicular to the chest wall. The objective of this study was to assess the volumetric compatibility between the Byrne measurement technique and the RECIST response criteria. Methods: We developed a mathematical crescent model to represent the growth pattern of MM. Measurements of this model were calculated according to the measurement techniques of RECIST and Byrne. Equations were derived to relate change in tumor measurements to corresponding changes in tumor-model volume. We utilized volumetric criteria for response based on the unidimensional criteria of RECIST: 30% decrease for partial response (PR) corresponds to a 66% decrease in volume of a sphere; 20% increase for progressive disease (PD) corresponds to 73% increase in volume of a sphere. We calculated volumetric differences between the RECIST response criteria applied to thickness measurements of spherical tumors and to thickness measurements of the MM model. Results: When RECIST criteria were applied to thickness measurements of the model, PR corresponded to a 30% volume decrease, which is less than the 66% volume decrease applied to spherical tumors; PD corresponded to a 20% volume increase, which is less than the 73% volume increase applied spherical tumors. Conclusions: The RECIST response criteria, as applied to MM measurements obtained with the Byrne technique, yield smaller changes in volume for both PR and PD compared with spherical tumors. For consistency with the volumetric criteria underlying RECIST, new response criteria are required for MM. No significant financial relationships to disclose.
35 MM. FILMS IN DIAGNOSIS OF CHEST CONDITIONS
Authors: Edmund C. Boots
Journal: Annals of Internal Medicine (1943)

Article1 June 194335 MM. FILMS IN DIAGNOSIS OF CHEST CONDITIONSEDMUND C. BOOTS, M.D., F.A.C.P.EDMUND C. BOOTS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-6-997 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe School Health Service Department of the Pittsburgh public schools serves approximately 130,000 children. When only those children were roentgen-rayed who showed enough abnormality to arouse suspicion on observation or physical examination, the standard 14 by 17 film method was sufficient to handle the volume of work.Two years ago it was decided to make tuberculin testing and roentgen-ray examination of all positive reactors compulsory for all competitive interscholastic athletes and ninth grade pupils. When this was done, demand arose for the testing and roentgenological examination of the remainder of the student body whose parents were desirous of having the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania*Presented before the Fifth Annual Regional Meeting of the American College of Physicians, Philadelphia, Pennsylvania, October 23, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1943Volume 18, Issue 6Page: 997-998KeywordsChildrenMedical servicesThoraxTuberculin ePublished: 1 December 2008 Issue Published: 1 June 1943 PDF downloadLoading ...
Malignant Lymphomas and Their Management.
Authors: Melville L. Jacobs
Journal: Annals of Internal Medicine (1969)

trated with clinical photographs, radiographs, and photo- micrographs of normal and abnormal amniotic mem- brane.The author has rightly drawn attention to a fascinating series of lesions which may culminate in severe foetal malformation or even intrauterine death of the foetus.It is possible, however, that not all the deformities result only from rupture of the amniotic membrane, and the cause of the latter remains obscure.