THE ANABOLIC EFFECTS OF THE ANDROGENS AND SOMATIC GROWTH IN MAN
Authors: Allan T. Kenyon, Kathryn Knowlton, Irene Sandiford
Journal: Annals of Internal Medicine (1944)

Article1 April 1944THE ANABOLIC EFFECTS OF THE ANDROGENS AND SOMATIC GROWTH IN MANALLAN T. KENYON, KATHRYN KNOWLTON, IRENE SANDIFORDALLAN T. KENYONSearch for more papers by this author, KATHRYN KNOWLTONSearch for more papers by this author, IRENE SANDIFORDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-4-632 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1889 Brown-Sequard,1then 72 years old, injected a testicular extract into himself and felt a return of his youthful sense of well-being. Little substance remains from this early experiment in human organotherapy although historians speak of an impetus given thereby to endocrine research. Such extracts of the testis are inactive in simple objective tests, and the subjective and probably imaginative character of Brown-Sequard's response never inspired much confidence in his interpretation of testicular function. Nevertheless the very prominence of this experiment in the history of endocrinology has served to keep alive Brown-Sequard's guiding thought that the testis might exert...Bibliography1. BROWN-SEQUARD CE: Expérience démontrant la puissance dynamogénique chez l'homme d'un liquide de testicules d'animaux, Arch. de physiol. norm. et path., 1889, xxi, 651, 740. Google Scholar2. SACCHI E: Di un caso di gigantismo infantile (pedomacrosomia) con tumore del testiculo, Riv. sper. di freniat., 1895, xxi, 149. Translation and illustrations given by Rowlands and Nicholson. Google Scholar3. ROWLANDSNICHOLSON RPGW: Growth of left testicle with precocious sexual and bodily development (macro-genitosomia), Guy's Hosp. Rep., 1929, lxxix, 401. Google Scholar4. 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Erwin Schwenk and Max Gilbert of the Schering Corp., Bloomfield, N. J. 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