TYPE VIII PNEUMOCOCCUS: DEVELOPMENT OF SULFADIAZINE RESISTANCE, TRANSMISSION BY CROSS INFECTION, AND PERSISTENCE IN CARRIERS
Authors: Arthur W. Frisch, Alvin E. Price, Gordon B. Myers
Journal: Annals of Internal Medicine (1943)

Article1 March 1943TYPE VIII PNEUMOCOCCUS: DEVELOPMENT OF SULFADIAZINE RESISTANCE, TRANSMISSION BY CROSS INFECTION, AND PERSISTENCE IN CARRIERSARTHUR W. FRISCH, M.D., ALVIN E. PRICE, M.D., F.A.C.P., GORDON B. MYERS, M.D., F.A.C.P.ARTHUR W. FRISCH, M.D.Search for more papers by this author, ALVIN E. PRICE, M.D., F.A.C.P.Search for more papers by this author, GORDON B. MYERS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-3-271 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of the present study is to report the development of "sulfadiazine-tolerance" by a type VIII pneumococcus and the transmission of this strain to another patient by cross infection. The evidence to be presented in support of drug-fastness was obtained from the clinical course, laboratory findings, sputum examination, and growth studies of the pneumococci in media containing sulfonamides.For the technic and detailed results of sputum examination, the reader is referred to previous publications. Serum therapy produced clumping and increased phagocytosis of pneumococci in the sputum, which was usually followed by a gradual decline in the number.3The characteristic...Bibliography1. AUGER WJ: Sulfapyridine resistance of pneumococci following sulfapyridine therapy in infants and children and the comparative potency of three chemotherapeutic agents for pneumococci as shown by laboratory tests, Jr. Pediat., 1941, xviii, 162. CrossrefGoogle Scholar2. CARPENTERCHARLESALLISON CMRSD: Effect of gradually increased concentrations of sulfathiazole on the gonococcus in vitro, Proc. Soc. Exper. Biol. and Med., 1942, xlviii, 476. Google Scholar3. FRISCH AW: Sputum studies in pneumonia: phagocytosis and the effect of serum therapy, Proc. Soc. Exper. Biol. and Med., 1938, xxxix, 473. CrossrefGoogle Scholar4. FRISCH AW: Sputum studies in pneumonia as an aid in prognosis, Am. Jr. Clin. Path., 1940, x, 472. CrossrefGoogle Scholar5. FRISCH AW: Sputum studies in pneumonia: The effect of sulfanilamide, Jr. Lab. and Clin. Med., 1940, xxv, 361. Google Scholar6. FRISCH AW: Sputum studies in pneumonia: The effect of sulfapyridine and sulfathiazole, Am. Jr. Clin. Path., 1942, xii, 16. CrossrefGoogle Scholar7. FRISCH AW: Sputum studies in pneumonia: In vivo and in vitro susceptibility of pneumococci to sulfapyridine and sulfathiazole, Am. Jr. Clin. Path., 1941, xi, 797. CrossrefGoogle Scholar8. HAMBURGERSCHMIDTRUEGSEGGERSESLERGRAPEN MLHJMCLES: Sulfonamide resistance developing during treatment of pneumococcic endocarditis, Jr. Am. Med. Assoc., 1942, cxix, 409. CrossrefGoogle Scholar9. LOWELLSTRAUSSFINLAND FCEM: Observations on the susceptibility of pneumococci to sulfapyridine, sulfathiazole and sulfamethylthiazole, ANN. INT. MED., 1940, xiv, 1001. Google Scholar10. ROSS RW: Acquired tolerance of pneumococcus to M. & B. 693, Lancet, 1939, i, 1207. CrossrefGoogle Scholar11. SCHMIDTHILLESDETTWILER LHCHA: The response of different types and strains of pneumococci to sulfapyridine, Jr. Infect. Dis., 1940, lxvii, 232. CrossrefGoogle Scholar12. SCHMIDTSESLERDETTWILER LHCHA: Studies on sulfonamide-resistant organisms: I. Development of sulfapyridine resistance by pneumococci, Jr. Pharmacol. and Exper. Therap., 1942, lxxiv, 175. Google Scholar13. SESLERSCHMIDT CLLH: Studies on sulfonamide resistant organisms: II. Comparative development of resistance to different sulfonamides by pneumococci, Jr. Pharmacol. and Exper. Therap., 1942, lxxv, 356. Google Scholar14. STRAUSSDINGLEFINLAND EJHM: Studies on the mechanism of sulfonamide bacteriostasis, inhibition and resistance: experiments with E. coli on a synthetic medium, Jr. Immunol., 1941, xlii, 313. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Battle Creek, Michigan*Received for publication October 12, 1942.From the Departments of Bacteriology and Internal Medicine, Wayne University College of Medicine, and the Medical Service of Receiving Hospital, Detroit, Mich.Supported by a grant from the Commonwealth Fund to the Michigan Department of Health Laboratories. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPuzzling Over the Pneumococcal PangenomeHistory of Drug-Resistant MicrobesHistory of Drug-Resistant MicrobesBACTERIAL RESISTANCE AND ANTIBIOTIC USE IN THE EMERGENCY DEPARTMENTEmerging pathogens that cause pneumonia in childrenAntibiotic-Resistant PneumococciWorld-wide development of antibiotic resistance in pneumococciEmergence of Multiply Resistant PneumococciAntibiotic-ressistant Streptococcus pneumoniae: Implications for Management in the 21st CenturyChanging patterns of bacterial resistance to antimicrobial drugsRecent advances in bacterial chemotherapy 1 March 1943Volume 18, Issue 3Page: 271-278KeywordsBacteriologyClinical laboratoriesDrugsHospital medicineMedical servicesPhagocytosisPneumococcusSerotherapySputumSulfonamide ePublished: 1 December 2008 Issue Published: 1 March 1943 Copyright & PermissionsCopyright, 1943, by The American College of PhysiciansPDF downloadLoading ...