tbuckley/cabot-search huggingface dataset:
Reappraisal of prognostic factors in CNS WHO grade 3 oligodendrogliomas IDH-mutant and 1p/19q co-deleted: lessons from the French POLA cohort
Authors: Domique Figarella-Branger, Carole Colin, Karima Mokhtari, Emmanuelle Uro-Coste, Ahmed Idbaih, Romain Appay, Emeline Tabouret, Mehdi Touat, Antoine Seyve, Catherine Carpentier, Caroline Dehais, François Ducray, C Desenclos, N Guillain, P Menei, A Rousseau, T Cruel, S Lopez, M Abad, N Hamdan, C Adam, F Parker, R Seizeur, I Quintin-Roué, G Chotard, C Bronnimann, D Ricard, C Godfraind, T Khallil, D Cazals-Hatem, T Faillot, C Gaultier, MC Tortel, I Carpiuc, P Richard, H Aubriot-Lorton, F Ghiringhelli, A Djelad, CA Maurage, EM Gueye, F Labrousse, F Ducray, D Meyronet, D Figarella-Branger, O Chinot, L Bauchet, V Rigau, G Gauchotte, L Taillandier, M Campone, D Loussouarn, V Bourg, F Vandenbos-Burel, J-S Guillamo, P Roger, C Blechet, H Adle-Biassette, F Bielle, A Carpentier, C Dehais, S Milin, M Wager, P Colin, MD Diebold, D Chiforeanu, E Vauleon, F Marguet, O Langlois, F Forest, MJ Motso-Fotso, M Andraud, M Khettab, B Lhermitte, G Noel, M Bernier, N Younan, C Rousselot-Denis, I Zemmoura, C Joubert, E Cohen-Moyal, E Uro-Coste, F Dhermain
Journal: Neuro-Oncology (2024)

Abstract Background In the POLA cohort, 3 pathological groups of CNS WHO grade 3 oligodendroglioma IDH-mutant and 1p/19q co-deleted have been described: group 1 (high mitotic count only), group 2 (microvascular proliferation MVP and no necrosis), and group 3 (MVP and necrosis). Methods 494 patients from the POLA cohort, with a median follow-up of 96 months were included. To identify the impact of the pathological groups and contrast enhancement (CE) in group 1 on overall survival (OS) or progression-free survival (PFS), survival curves were obtained (Kaplan–Meier method) and compared (log-rank test). The prognostic value of clinical factors and CDKN2A homozygous deletion HD were also tested. Multivariate analysis was performed. Results Survival analysis demonstrated that the pathological groups were associated with both progression-free survival (PFS P = .01) and overall survival (OS P = .001). In group 1, patients with CE (1CE+) had a poorer prognosis compared to those without (OS P = .028, PFS P = .006). Further stratification into group 1CE−, group 1CE+, group 2, and group 3 provided clearer prognostic distinctions (OS P = .002, PFS P &amp;lt; .0001). Other prognostic factors included age (OS P &amp;lt; .0001, PFS P = .002), extent of surgical resection (OS P = .001, PFS P = .003), KPS (OS P &amp;lt; .0001, PFS P = 0.002), postoperative treatment (OS P = .007, PFS P &amp;lt; .0001), and CDKN2A HD (OS and PFS P &amp;lt; .0001). The pathological groups remained of prognostic significance for PFS in multivariate analysis. Conclusions Necrosis and CDKN2A HD are adverse prognostic factors of WHO grade 3 oligodendrogliomas, IDH-mutant, and 1p/19q co-deleted. Besides, in group 1 patients, lack of CE is a factor of better prognosis.
Primary cutaneous T-cell lymphoma not otherwise specified (NOS) uncovering a novel RAB27A variant in Griscelli syndrome type 2
Authors: Gabriela Blanchard, Isis Atallah, Maël Blanchard, Birgit Fehrenbacher, Martin Schaller, Orbicia Riccio, Claudia Ballerini, Fabio Candotti, Emmanuella Guenova
Journal: British Journal of Dermatology (2024)

Griscelli syndrome type 2 (GS2) is a rare, autosomal recessive disorder that typically emerges during childhood. It manifests with partial albinism, silvery hair, immunodeficiency and hemophagocytic lymphohistiocytosis predisposition (HLH). Our findings suggest that lymphoproliferative disorders, including cutaneous lymphomas, should be considered part of the dermatological spectrum of GS2. While GS2 has previously been diagnosed in adults presenting with HLH, our observations indicate that HLH is not an inevitable outcome, even in patients who survive into their fifth decade of life.
Trends in NHANES Biomonitored Exposures in California and the United States following Enactment of California’s Proposition 65
Authors: Kristin E. Knox, Megan R. Schwarzman, Ruthann A. Rudel, Claudia Polsky, Robin E. Dodson
Journal: Environmental Health Perspectives (2024)

The prevalence of toxic chemicals in US commerce has prompted some states to adopt laws to reduce exposure. One with broad reach is California's Proposition 65 (Prop 65), which established a list of chemicals that cause cancer, developmental harm, or reproductive toxicity. The law is intended to discourage businesses from using these chemicals and to minimize consumer exposure. However, a key question remains unanswered: Has Prop 65 reduced population-level exposure to the listed chemicals?
Genetically modified extracellular vesicles loaded with activated gasdermin D potentially inhibit prostate-specific membrane antigen-positive prostate carcinoma growth and enhance immunotherapy
Authors: Ke Gao, Wenjin Xi, Jianxin Ni, Jun Jiang, Yonghua Lei, Lin Li, Jie Chu, Ruixiao Li, Yongpan An, Yanan Ouyang, Ruiping Su, Rui Zhang, Guojun Wu
Journal: Biomaterials (2024)
Electrically-driven drug delivery into deep cutaneous tissue by conductive microneedles for fungal infection eradication and protective immunity
Authors: Sumanta Ghosh, Mengjia Zheng, Jiahui He, Yefeng Wu, Yaming Zhang, Weiping Wang, Jie Shen, Kelvin W K Yeung, Prasanna Neelakantan, Chenjie Xu, Wei Qiao
Journal: Biomaterials (2024)
Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy
Authors: Jintong Yang, Yiteng Lu, Kexin Hu, Xinchen Zhang, Wei Wang, Deyong Ye, Mingguang Mo, Xin Xiao, Xichen Wan, Yuqing Wu, Shuxian Zhang, He Huang, Zhibei Qu, Yimin Hu, Yu Cao, Jiaxu Hong, Lu Zhou
Journal: Acta Pharmaceutica Sinica B (2024)

Dry eye disease (DED) is a prevalent and intractable ocular disease induced by a variety of causes. Elevated sphingomyelin (SM) levels and pro-inflammatory cytokines were detected on the ocular surface of DED patients, particularly in the meibomian glands. Sphingomyelin synthase 2 (SMS2), one of the proteins involved in SM synthesis, would light a novel way of developing a DED therapy strategy. Herein, we report the design and optimization of a series of novel thiophene carboxamide derivatives to afford 14l with an improved highly potent inhibitory activity on SM synthesis (IC50, SMS2 = 28 nmol/L). Moreover, 14l exhibited a notable protective effect of anti-inflammation and anti-apoptosis on human corneal epithelial cells (HCEC) under TNF-α-hyperosmotic stress conditions in vitro, with an acceptable ocular specific distribution (corneas and meibomian glands) and pharmacokinetics (PK) profiles (t 1/2, cornea = 1.11 h; t 1/2, meibomian glands = 4.32 h) in rats. Furthermore, 14l alleviated the dry eye symptoms including corneal fluorescein staining scores and tear secretion in a dose-dependent manner in mice. Mechanically, 14l reduced the mRNA expression of Tnf-α, Il-1β and Mmp-9 in corneas, as well as the proportion of very long chain SM in meibomian glands. Our findings provide a new strategy for DED therapy based on selective SMS2 inhibitors.
Ensemble transformer-based multiple instance learning to predict pathological subtypes and tumor mutational burden from histopathological whole slide images of endometrial and colorectal cancer
Authors: Ching-Wei Wang, Tzu-Chien Liu, Po-Jen Lai, Hikam Muzakky, Yu-Chi Wang, Mu-Hsien Yu, Chia-Hua Wu, Tai-Kuang Chao
Journal: Medical Image Analysis (2024)
Fecal Microbiota Transplantation Outcome and Gut Microbiota Composition in Ulcerative Colitis: a Systematic Review and Meta-analysis
Authors: M V Bénard, M C de Goffau, J Blonk, F Hugenholtz, J van Buuren, S Paramsothy, N O Kaakoush, G R A M D'Haens, T J Borody, M A Kamm, C Y Ponsioen
Journal: Clinical Gastroenterology and Hepatology (2024)
Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling
Authors: Ning Li, Ya-Jie Sun, Li-Yun Huang, Rong-Rong Li, Jun-Sheng Zhang, Ai-Hua Qiu, Jing Wang, Lu Yang
Journal: Drug Resistance Updates (2024)
Biologically Logic-Gated Trojan-Horse Strategy for Personalized Triple-Negative Breast Cancer Precise Therapy by Selective Ferroptosis and STING Pathway Provoking
Authors: Shuai Guo, Tianwang Guan, Yushen Ke, Yuping Lin, Rundong Tai, Jujian Ye, Zhilin Deng, Shaohui Deng, Caiwen Ou
Journal: Biomaterials (2024)
A phase III trial of adjuvant ribociclib plus endocrine therapy vs endocrine therapy alone in patients with HR+/HER2− early breast cancer: final invasive disease–free survival results from the NATALEE trial
Authors: G N Hortobagyi, A Lacko, J Sohn, F Cruz, M Ruiz Borrego, A Manikhas, Y Hee Park, D Stroyakovskiy, D A Yardley, C-S Huang, P A Fasching, J Crown, A Bardia, S Chia, S-A Im, M Martin, S Loi, B Xu, S Hurvitz, C Barrios, M Untch, R Moroose, F Visco, F Parnizari, J P Zarate, Z Li, S Waters, A Chakravartty, D Slamon
Journal: Annals of Oncology (2024)
The Ethical Standard for End-of-Life Decisions for Unrepresented Patients
Authors: Matthew Shea
Journal: The American Journal of Bioethics (2024)

There has been increasing awareness of the medical and moral challenges in the care of unrepresented patients: those who cannot make their own medical decisions, do not have any surrogate decision maker, and have not indicated their treatment preferences. Most discussions have focused on procedural questions such as who should make decisions for these patients. An issue that has not gotten enough attention is the ethical standard that should govern medical decision making. I explore the question of which ethical standard provides better justification for end-of-life decisions for unrepresented patients. Two options are considered: the conventional and less demanding best interest standard, and the novel and more demanding medical futility standard. I explain the similarities and differences between these two standards, examine arguments for and against each one, and suggest that the medical futility standard is ethically superior and should replace the established best interest standard.
Concordance of ctDNA and tissue genomic profiling in advanced biliary tract cancer
Authors: Sohyun Hwang, Seonjeong Woo, Beodeul Kang, Haeyoun Kang, Jung Sun Kim, Sung Hwan Lee, Chang Il Kwon, Dong Soo Kyung, Hwang-Phill Kim, Gwangil Kim, Chan Kim, Hong Jae Chon
Journal: Journal of Hepatology (2024)
Improvement of Platysma Prominence With OnabotulinumtoxinA: Safety and Efficacy Results From a Randomized, Double-Blinded, Placebo-Controlled Phase 3 Trial
Authors: Sabrina Fabi, Shannon Humphrey, Brian Biesman, Rosalyn George, Brenda LaTowsky, Robert A Weiss, Grace S Park, Sandhya Shimoga, Elisabeth Lee, Edward Jierjian, Warren Tong, René Hopfinger
Journal: Journal of the American Academy of Dermatology (2024)
Clinical characteristics and outcomes of dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid patients: A retrospective study
Authors: Inkin Ujiie, Sho Katayama, Yosuke Mai, Shoko Mai, Norihiro Yoshimoto, Ken Muramatsu, Hiroaki Iwata, Kentaro Izumi, Hideyuki Ujiie
Journal: Journal of the American Academy of Dermatology (2024)
Home-based transcranial direct current stimulation treatment for major depressive disorder: a fully remote phase 2 randomized sham-controlled trial
Authors: Rachel D Woodham, Sudhakar Selvaraj, Nahed Lajmi, Harriet Hobday, Gabrielle Sheehan, Ali-Reza Ghazi-Noori, Peter J Lagerberg, Maheen Rizvi, Sarah S Kwon, Paulette Orhii, David Maislin, Lucia Hernandez, Rodrigo Machado-Vieira, Jair C Soares, Allan H Young, Cynthia H Y Fu
Journal: Nature Medicine (2024)
Finding Long-COVID: temporal topic modeling of electronic health records from the N3C and RECOVER programs
Authors: Shawn T O'Neil, Charisse Madlock-Brown, Kenneth J Wilkins, Brenda M McGrath, Hannah E Davis, Gina S Assaf, Hannah Wei, Parya Zareie, Evan T French, Johanna Loomba, Julie A McMurry, Andrea Zhou, Christopher G Chute, Richard A Moffitt, Emily R Pfaff, Yun Jae Yoo, Peter Leese, Robert F Chew, Michael Lieberman, Melissa A Haendel
Journal: npj Digital Medicine (2024)
Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data
Authors: Sara Saez-Atienzar, Cleide Dos Santos Souza, Ruth Chia, Selina N Beal, Ileana Lorenzini, Ruili Huang, Jennifer Levy, Camelia Burciu, Jinhui Ding, J Raphael Gibbs, Ashley Jones, Ramita Dewan, Viviana Pensato, Silvia Peverelli, Lucia Corrado, Joke J F A van Vugt, Wouter van Rheenen, Ceren Tunca, Elif Bayraktar, Menghang Xia, Alfredo Iacoangeli, Aleksey Shatunov, Cinzia Tiloca, Nicola Ticozzi, Federico Verde, Letizia Mazzini, Kevin Kenna, Ahmad Al Khleifat, Sarah Opie-Martin, Flavia Raggi, Massimiliano Filosto, Stefano Cotti Piccinelli, Alessandro Padovani, Stella Gagliardi, Maurizio Inghilleri, Alessandra Ferlini, Rosario Vasta, Andrea Calvo, Cristina Moglia, Antonio Canosa, Umberto Manera, Maurizio Grassano, Jessica Mandrioli, Gabriele Mora, Christian Lunetta, Raffaella Tanel, Francesca Trojsi, Patrizio Cardinali, Salvatore Gallone, Maura Brunetti, Daniela Galimberti, Maria Serpente, Chiara Fenoglio, Elio Scarpini, Giacomo P Comi, Stefania Corti, Roberto Del Bo, Mauro Ceroni, Giuseppe Lauria Pinter, Franco Taroni, Eleonora Dalla Bella, Enrica Bersano, Charles J Curtis, Sang Hyuck Lee, Raymond Chung, Hamel Patel, Karen E Morrison, Johnathan Cooper-Knock, Pamela J Shaw, Gerome Breen, Richard J B Dobson, Clifton L Dalgard, Sonja W Scholz, Ammar Al-Chalabi, Leonard H van den Berg, Russell McLaughlin, Orla Hardiman, Cristina Cereda, Gianni Sorarù, Sandra D'Alfonso, Siddharthan Chandran, Suvankar Pal, Antonia Ratti, Cinzia Gellera, Kory Johnson, Tara Doucet-O'Hare, Nicholas Pasternack, Tongguang Wang, Avindra Nath, Gabriele Siciliano, Vincenzo Silani, Ayşe Nazlı Başak, Jan H Veldink, William Camu, Jonathan D Glass, John E Landers, Adriano Chiò, Rita Sattler, Christopher E Shaw, Laura Ferraiuolo, Isabella Fogh, Bryan J Traynor
Journal: Cell Genomics (2024)
Overnutrition causes insulin resistance and metabolic disorder through increased sympathetic nervous system activity
Authors: Kenichi Sakamoto, Mary A Butera, Chunxue Zhou, Giulia Maurizi, Bandy Chen, Li Ling, Adham Shawkat, Likhitha Patlolla, Kavira Thakker, Victor Calle, Donald A Morgan, Kamal Rahmouni, Gary J Schwartz, Azeddine Tahiri, Christoph Buettner
Journal: Cell Metabolism (2024)
Adjudication of Hospitalizations and Deaths in the IRONMAN Trial of Intravenous Iron for Heart Failure
Authors: John G F Cleland, Pierpaolo Pellicori, Fraser J Graham, Rebecca Lane, Mark C Petrie, Fozia Ahmed, Iain B Squire, Andrew Ludman, Alan Japp, Abdallah Al-Mohammad, Andrew L Clark, Ben Szwejkowski, Chris Critoph, Victor Chong, Rebekah Schiff, Thuraia Nageh, Jason Glover, John J V McMurray, Elizabeth A Thomson, Michele Robertson, Ian Ford, Philip A Kalra, Paul R Kalra
Journal: Journal of the American College of Cardiology (2024)

Patients with heart failure and iron deficiency have diverse causes for hospitalization and death that might be affected by iron repletion.
AI-Facilitated Assessment of Built Environment Using Neighborhood Satellite Imagery and Cardiovascular Risk
Authors: Zhuo Chen, Pedro Rafael Vieira de Oliveira Salerno, Jean-Eudes Dazard, Santosh Kumar Sirasapalli, Mohamed H E Makhlouf, Issam Motairek, Skanda Moorthy, Sadeer Al-Kindi, Sanjay Rajagopalan
Journal: Journal of the American College of Cardiology (2024)
Platelet FcγRIIa as a Marker of Cardiovascular Risk After Myocardial Infarction
Authors: David J Schneider, Sean R McMahon, Dominick J Angiolillo, Alexander Fanaroff, Homam Ibrahim, Patrick K Hohl, Brett L Wanamaker, Mark B Effron, Peter M DiBattiste
Journal: Journal of the American College of Cardiology (2024)
Mortality trends, gender, and racial disparities in older adults due to abdominal aortic aneurysm: A nationwide cross-sectional analysis
Authors: Aman Goyal, Humza Saeed, Syeda Shahnoor, Muhammad Khubaib Arshad, Abdul Wasay, None Abdullah, Mohamed Daoud, Amir Humza Sohail
Journal: International Journal of Surgery (2024)

Abdominal aortic aneurysms (AAAs) are a significant vascular pathology in older adults, often asymptomatic but with high mortality upon rupture. Despite advancements in diagnostic imaging and surgical interventions, AAAs remain a public health concern. This research letter analyzed CDC WONDER data on AAA-related deaths (ICD-10 I71.3 and I71.4) among US adults aged 65+ from 1999 to 2020. Age-adjusted mortality rates (AAMRs) and annual percent change (APC) were calculated by year, sex, age group, race/ethnicity, geography, and urbanization status. Between 1999 and 2020, there were 180 037 reported deaths in older adults due to AAA. The overall AAMR decreased from 32.6 to 13.2 per 100 000, with a significant decline from 2014 to 2020 (APC: −1.66; 95% CI: −2.48 to −0.48). Older men had a significantly higher AAMR than older women (31.2 vs. 12). Among racial and ethnic groups, Non-Hispanic (NH) Whites had the highest AAMR at 21.7, followed by NH American Indian or Alaska Native (14.5), NH Black (12.6), NH Asian or Pacific Islander (10.1), and Hispanic populations (8.4). Additionally, non-metropolitan areas exhibited higher AAMRs compared to metropolitan areas (23.9 vs. 18.7). While mortality rates have declined, disparities remain, with higher rates among older men, NH Whites, and non-metropolitan residents, highlighting the need for targeted and equitable interventions.
Results from Arm A of Phase 1/2 DREAMM-6 trial: belantamab mafodotin with lenalidomide plus dexamethasone in patients with relapsed/refractory multiple myeloma
Authors: Rakesh Popat, Bradley Augustson, Mercedes Gironella, Cindy Lee, Paul Cannell, Nashita Patel, Ravi S Kasinathan, Rachel Rogers, Mehreen Shaikh, Amy Curry, Fernando Carreño, Sumita Roy-Ghanta, Joanna Opalinska, Hang Quach
Journal: Blood Cancer Journal (2024)
Evolutionary dynamics of pro-inflammatory caspases in primates and rodents
Authors: Mische Holland, Rachel Rutkowski, Tera C. Levin
Journal: Molecular Biology and Evolution (2024)

Caspase-1 and related proteases are key players in inflammation and innate immunity. Here, we characterize the evolutionary history of caspase-1 and its close relatives across 19 primates and 21 rodents, focusing on differences that may cause discrepancies between humans and animal studies. While caspase-1 has been retained in all these taxa, other members of the caspase-1 subfamily (caspase-4, caspase-5, caspase-11, and caspase-12 and CARD16, 17, and 18) each have unique evolutionary trajectories. Caspase-4 is found across simian primates, whereas we identified multiple pseudogenization and gene loss events in caspase-5, caspase-11, and the CARDs. Because caspase-4 and caspase-11 are both key players in the noncanonical inflammasome pathway, we expected that these proteins would be likely to evolve rapidly. Instead, we found that these two proteins are largely conserved, whereas caspase-4's close paralog, caspase-5, showed significant indications of positive selection, as did primate caspase-1. Caspase-12 is a nonfunctional pseudogene in humans. We find this extends across most primates, although many rodents and some primates retain an intact, and likely functional, caspase-12. In mouse laboratory lines, we found that 50% of common strains carry nonsynonymous variants that may impact the functions of caspase-11 and caspase-12 and therefore recommend specific strains to be used (and avoided). Finally, unlike rodents, primate caspases have undergone repeated rounds of gene conversion, duplication, and loss leading to a highly dynamic proinflammatory caspase repertoire. Thus, we uncovered many differences in the evolution of primate and rodent proinflammatory caspases and discuss the potential implications of this history for caspase gene functions.
Functional optimization in distinct tissues and conditions constrains the rate of protein evolution
Authors: Dinara R Usmanova, Germán Plata, Dennis Vitkup
Journal: Molecular Biology and Evolution (2024)

Abstract Understanding the main determinants of protein evolution is a fundamental challenge in biology. Despite many decades of active research, the molecular and cellular mechanisms underlying the substantial variability of evolutionary rates across cellular proteins are not currently well understood. It also remains unclear how protein molecular function is optimized in the context of multicellular species and why many proteins, such as enzymes, are only moderately efficient on average. Our analysis of genomics and functional datasets reveals in multiple organisms a strong inverse relationship between the optimality of protein molecular function and the rate of protein evolution. Furthermore, we find that highly expressed proteins tend to be substantially more functionally optimized. These results suggest that cellular expression costs lead to more pronounced functional optimization of abundant proteins, and that the purifying selection to maintain high levels of functional optimality significantly slows protein evolution. We observe that in multicellular species both the rate of protein evolution and the degree of protein functional efficiency are primarily affected by expression in several distinct cell types and tissues. Specifically, in developed neurons with upregulated synaptic processes in animals and in young and fast-growing tissues in plants. Overall, our analysis reveals how various constraints from the molecular, cellular, and species’ levels of biological organization jointly affect the rate of protein evolution and the level of protein functional adaptation.
Gentrius: generating trees compatible with a set of unrooted subtrees and its application to phylogenetic terraces
Authors: Olga Chernomor, Christiane Elgert, Arndt von Haeseler
Journal: Molecular Biology and Evolution (2024)

Abstract For a set of binary unrooted subtrees generating all binary unrooted trees compatible with them, i.e. generating their stand, is one of the classical problems in phylogenetics. Here, we introduce Gentrius – an efficient algorithm to tackle this task. The algorithm has a direct application in practice. Namely, Gentrius generates phylogenetic terraces - topologically distinct, equally scoring trees due to missing data. Despite stand generation being computationally intractable, we showed on simulated and biological datasets that Gentrius generates stands with millions of trees in feasible time. We exemplify that depending on the distribution of missing data across species and loci and the inferred phylogeny, the number of equally optimal terrace trees varies tremendously. The strict consensus tree computed from them displays all the branches unaffected by the pattern of missing data. Thus, by solving the problem of stand generation, in practice Gentrius provides an important systematic assessment of phylogenetic trees inferred from incomplete data. Furthermore, Gentrius can aid theoretical research by fostering understanding of tree space structure imposed by missing data.
Mapping lineage-traced cells across time points with moslin
Authors: Marius Lange, Zoe Piran, Michal Klein, Bastiaan Spanjaard, Dominik Klein, Jan Philipp Junker, Fabian J. Theis, Mor Nitzan
Journal: Genome biology (2024)

Simultaneous profiling of single-cell gene expression and lineage history holds enormous potential for studying cellular decision-making. Recent computational approaches combine both modalities into cellular trajectories; however, they cannot make use of all available lineage information in destructive time-series experiments. Here, we present moslin, a Gromov-Wasserstein-based model to couple cellular profiles across time points based on lineage and gene expression information. We validate our approach in simulations and demonstrate on Caenorhabditis elegans embryonic development how moslin predicts fate probabilities and putative decision driver genes. Finally, we use moslin to delineate lineage relationships among transiently activated fibroblast states during zebrafish heart regeneration.