tbuckley/cabot-search huggingface dataset:
Genome Sequencing and Genetic Association Analyses of Primary Glomerular Disorders in CureGN, NEPTUNE, and Columbia CKD Biobank
Authors: Chen Wang, Simone Sanna-Cherchi, Matt G. Sampson, Rasheed A. Gbadegesin, Ali G. Gharavi, Matthias Kretzler, Krzysztof Kiryluk
Journal: Journal of the American Society of Nephrology (2024)
Associations between APOL1 Genotypes and Major Adverse Cardiovascular Events (MACE) in Proteinuric Glomerulopathies: A CureGN and NEPTUNE Study
Authors: Matthew Schuchman, Roy O. Mathew, Abigail R. Smith, Agustin Gonzalez-Vicente, Crystal A. Gadegbeku, Sharon G. Adler, Dorey A. Glenn, Meryl Waldman, Markus Bitzer, Fadhl Alakwaa, Bryce A. Kerlin, Patrick H. Nachman, Bruce M. Robinson, Myda Khalid, Vimal K. Derebail, Tarak Srivastava, Gentzon Hall, Katherine R. Tuttle, Michelle M. O'Shaughnessy, Gabriel M. Cara-Fuentes, Bethany Angela Roehm, Jarcy Zee, Christine B. Sethna
Journal: Journal of the American Society of Nephrology (2024)
T Cell Egress from the Kidney to the Renal Lymph Node Is Regulated by Their Activation State and Controls Tissue Inflammation
Authors: Jonas Engesser, Jan-Hendrik Riedel, Nariaki Asada, Hans-Joachim Paust, Robin Khatri, Zeba Sultana, Catherine Meyer-Schwesinger, Thorsten Wiech, Victor G. Puelles, Stefan Bonn, Christian F. Krebs, Ulf Panzer
Journal: Journal of the American Society of Nephrology (2024)
Cathepsin B Alleviates the Development of Focal Segmental Glomerulosclerosis
Authors: Franziska Theilig, Mairon Trujillo Miranda, Jessica Promnitz, Makhabbat Saudenova, Magdalena Westermann, Geraldine Mollet, Theresa Riebeling, Stefan Krautwald, Fatih Demir, Markus M. Rinschen, Eileen Dahlke
Journal: Journal of the American Society of Nephrology (2024)
Differentiated Cell Types in the Kidney's Thick Ascending Limb: Functional Insights on TAL α and TAL β
Authors: Jessica Paola Bahena-López, Jonathan W. Nelson, Xiao-Tong Su, Hasan Demirci, Joshua N. Curry, Markus Bleich, Sebastian Bachmann, David H. Ellison
Journal: Journal of the American Society of Nephrology (2024)
Detection of Medial Vascular Calcification in Patients with CKD Using Cost-Effective Classifiers
Authors: Bengt Lindholm, Urszula Bialonczyk, Malgorzata Debowska, Abdul Rashid Tony Qureshi, Leon Bobrowski, Magnus Soderberg, Peter Stenvinkel, Tomasz Lukaszuk, Jan T. Poleszczuk
Journal: Journal of the American Society of Nephrology (2024)
Ccr2 Targeting Does Not Ameliorate Disease Phenotype in a Model of UMOD-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Authors: Mariapia Giuditta Cratere, Francesca Nicola, Matteo Trudu, Celine Schaeffer, Luca Rampoldi
Journal: Journal of the American Society of Nephrology (2024)
Association of Zinc Deficiency with Abdominal Fat and Muscle Mass Areas in Patients on Hemodialysis
Authors: Junko Ishida, Nao Muramoto, Masako Tanaka, Yoshiteru Yamada, Mayumi Yamada, Ai Asano, Teppei Matsuoka, Akihiko Kato
Journal: Journal of the American Society of Nephrology (2024)
Unexpected Early Hypercalcemia after Parathyroidectomy in a Patient with Tumoral Calcinosis and Severe Calciphylaxis
Authors: Ana Cristina Gonzalez Medina, Vianca Anabel Canaviri, Ana Lilia Ruelas Villavicencio, Paul Armando Parra, Ivan Perez Diaz, Jose Armando Paz Cortes, Juan Carlos Ramirez-Sandoval
Journal: Journal of the American Society of Nephrology (2024)
Competing Risks of Kidney Failure and Death by Baseline eGFR in Diabetes
Authors: Katherine R. Tuttle, Lindsey M. Kornowske, Kenn B. Daratha, Cami R. Jones, Christina Reynolds, Alain K. Koyama, Fang Xu, Yoshihisa Miyamoto, Joshua J. Neumiller, Radica Z. Alicic, Susanne B. Nicholas, Obidiugwu Duru, Keith C. Norris, Meda E. Pavkov
Journal: Journal of the American Society of Nephrology (2024)
Macrophage Activation Syndrome in an Adolescent Male with Dialysis-Dependent Kidney Failure and Systemic Lupus Erythematosus Flares
Authors: Subashini Azhagappa, Syeda Asfia Hussain, Asma B S Shaoba, Oluwatoyin F. Bamgbola
Journal: Journal of the American Society of Nephrology (2024)
Serum Metalloproteinase-8 (MMP-8) and Tissue Inhibition of Metalloproteinase-1 (TIMP-1) Pretransplant Levels Predict Early Graft Function after Kidney Transplantation
Authors: Kadri Hendrikson, Ilkka Helanterä, Seppo Meri, Timo Sorsa, Fernanda Ortiz
Journal: Journal of the American Society of Nephrology (2024)
Extracorporeal Carbon Dioxide Removal Instead of Mechanical Ventilation in a Patient with Respiratory Distress and Acute Kidney Failure, with Active Bleeding Using Regional Anticoagulation
Authors: Milton Kalil, Renato Eorgeg Eick, David Saitovich, Anna Cristina Stein, Lucas G. Da Luz, Illan George Balestrin, Marcelo Basso Gazzana, Mauricio Lutzky André
Journal: Journal of the American Society of Nephrology (2024)
Extracellular Vesicle and Modulation of miR-93 in Kidney Diseases
Authors: Laura Perin, Charmi Dedhia, Valentina Villani, Xiaogang Hou, Paolo Neviani, Geremy Clair, Velia Alcala, Paola Aguiari, Giuseppe Orlando, Roger E. De Filippo, Stefano Da Sacco, Benedetta Bussolati, Sargis Sedrakyan
Journal: Journal of the American Society of Nephrology (2024)
Exploratory Post Hoc Analysis of the CONVINCE Randomized Controlled Trial: Differential Treatment Effects of Hemodiafiltration (HDF) and Hemodialysis (HD) on Quality of Life
Authors: Krister Cromm, Felix Fischer, Claudia Maria Barth, Bernard J. Canaud, Jorgen BA Hegbrant, Giovanni Strippoli, Mark Woodward, Michiel L. Bots, Peter J. Blankestijn, Matthias Rose
Journal: Journal of the American Society of Nephrology (2024)
Assembly of a Functionally Mature Synthetic Kidney Organoid with Spatial Patterning from the Self-Organization of Expandable Kidney Progenitors
Authors: Pedro Medina, Biao Huang, Chennan Zhang, Megan Schreiber, Nuria M. Pastor-Soler, Andrew P. McMahon, Zhongwei Li
Journal: Journal of the American Society of Nephrology (2024)
Examining the Anti-inflammatory and Renoprotective Effects Resulting from Parasympathetic Nerve Stimulation after Inflammation
Authors: Sayumi Matsuo, Chia-Hsien Wu, Yasuna Nakamura, Norito Washimine, Ryusuke Umene, Tomoya Nishino, Tsuyoshi Inoue
Journal: Journal of the American Society of Nephrology (2024)
Declining Serum Albumin in the Shadow of Stable Body Mass Index: A Mortality Indicator in Predialysis CKD
Authors: Menaka Sarav, Prabin Shrestha, Adnan Naseer, Fridtjof Thomas, Keiichi Sumida, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy
Journal: Journal of the American Society of Nephrology (2024)
Noninvasive Urine Epigenomics Identifies Allograft Pathology in Kidney Allografts
Authors: Essa Abuhelaiqa, Mohamad M. Alkadi, Aziz Belkadi, Gaurav Thareja, Thangamani Muthukumar, Hassan A. Al-Malki, Manikkam Suthanthiran
Journal: Journal of the American Society of Nephrology (2024)
Developing a Participant-Focused Educational Podcast to Enhance Engagement in the Cure Glomerulopathy (CureGN) Study Cohort
Authors: Myda Khalid, Tina Creguer, Laura H. Mariani, Shannon Mulroy, Keisha L. Gibson, Sherry Louise Wilson, Zubin J. Modi, Caroline J. Poulton
Journal: Journal of the American Society of Nephrology (2024)
Barriers to Participation in CKD Clinical Trials: A 25-City Analysis
Authors: Gabriel Cojuc, Alan Braverman-Poyastro, Alejandra De Las Fuentes, Briana Rodriguez - Paniagua, Andrea Mizrahi Drijanski, Alberto Nordmann-Gomes, Alberto Moscona-Nissan, Alberto Guijosa, Denisse Nayely Tinajero Sánchez, Vianca Anabel Canaviri, Bhavna Chopra, Ricardo Correa-Rotter, Juan Carlos Ramirez-Sandoval
Journal: Journal of the American Society of Nephrology (2024)
Induction Therapy and Kidney Outcomes in Pediatric Lupus Nephritis: A Prospective Study from the Pediatric Nephrology Research Consortium
Authors: Melonie Anne Phillips, Mahmoud Kallash, Hancong Tang, Steve Rust, Scott E. Wenderfer, Tetyana L. Vasylyeva, Jerome C. Lane
Journal: Journal of the American Society of Nephrology (2024)
Kidney Impairment Exacerbates Periventricular White Matter Hyperintensities in Patients with CKD
Authors: Feng-Ching Shen, Yi-Ting Lin, Ming-Yen Lin, Mei-Chuan Kuo, Yi-Wen Chiu, Jer-Ming Chang, Shang-Jyh Hwang, Ping-Hsun Wu
Journal: Journal of the American Society of Nephrology (2024)
Selective Induction of Renal Interstitial Progenitor Cell Lineages from Human-Induced Pluripotent Stem Cells (hiPSCs) for Understanding of Mesangial and Erythropoietin (EPO)-Producing Cell Development and Kidney Regeneration
Authors: Hiraku Tsujimoto, Azusa Hoshina, Shin-ichi Mae, Toshikazu Araoka, Cecilia Graneli, Kevin Woollard, Kenji Osafune
Journal: Journal of the American Society of Nephrology (2024)
Phase II Results of an Investigational RNA Therapeutic to Complement Factor B, IONIS-FB-LRx, for Treatment of IgA Nephropathy
Authors: Sean Barbour, Michelle A. Hladunewich, Angela Makris, Sven-Jean Tan, Richard Austin Robson, Muh Geot Wong, Jason Choo Chon Jun, Ashley Frazer-Abel, Lixuan Yin, Terry Barrett, Richard Geary, Eugene Schneider, Jon Leslie Ruckle, Michael Mccaleb, Gary Todd Brice
Journal: Journal of the American Society of Nephrology (2024)
Comparative Effectiveness of Cyclophosphamide and Calcineurin Inhibitors in Childhood Nephrotic Syndrome
Authors: Cal Robinson, Josefina A. Brooke, Rahul Chanchlani, Brian H. Cuthbertson, Vaneet Dhillon, Eddy Fan, Christoph Licht, Ashlene Maree McKay, Damien Gerard Noone, Rachel Jane Pearl, Seetha Radhakrishnan, Veronique Rowley, Chia Wei Teoh, Jovanka Vasilevska-Ristovska, Rulan S. Parekh
Journal: Journal of the American Society of Nephrology (2024)
Liraglutide-Mediated Renoprotection in Type 1 Diabetes: Modulating M1/M2 Macrophage Balance via NOX/TRP Cross-Talk
Authors: Natalie Youssef, Mohamad Noureldein, Sarah Almoussawi, Tala Radwan Kaddoura, Fuad N. Ziyadeh, Assaad Antoine Eid
Journal: Journal of the American Society of Nephrology (2024)
Association of Insulin-Like Growth Factor 1 with Cardiovascular Outcomes in Individuals with or without CKD: The UK Biobank Study
Authors: Byounghwi Ko, Daseul Huh, Dong Hoon Kang, Ga Young Heo, Cheol Ho Park, Hyung Woo Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
Journal: Journal of the American Society of Nephrology (2024)
Methylation-Controlled J Protein as a Target to Alleviate Kidney Fibrosis and Cyst Growth
Authors: Marie-Louise T. Monaghan, Isabel A. Layne, Jelena Klawitter, Evgenia Dobrinskikh, Alyx E. Gray, Raphael A. Nemenoff, Michel Chonchol, Seth B. Furgeson, Katharina Hopp
Journal: Journal of the American Society of Nephrology (2024)
Benefits of Glucagon-Like Peptide 1 Receptor Agonists in Kidney Transplant Recipients
Authors: Oscar Alejandro Garcia Valencia, Sukhdeep Singh Sahi, Jie Na_, Byron H. Smith, Pooja Budhiraja, Tayyab S. Diwan, Naim S. Issa, Aleksandar Denic, Ahmed Abdelrheem, Hani Wadei, Yogish C. Kudva, Aleksandra Kukla
Journal: Journal of the American Society of Nephrology (2024)
Is a Bioimpedance Assay an Effective Tool for Evaluating Cardiac Parameters in Patients with ESKD Undergoing Hemodialysis? A Cross-Sectional Study from North India
Authors: Dinesh Khullar, Vandana Prasad, Rahul Grover, Sahil Bagai, Kulwant Singh, Prof Narinder Pal Singh, Deepak Kumar, Abhishek Singh, Anish Kumar Gupta
Journal: Journal of the American Society of Nephrology (2024)
Outcomes and Risk Factors of Widened Difference in Estimated Glomerular Filtration Rate by Creatinine or Cystatin C: Adjust Model Development with More than 300,000 UK Biobank Participants
Authors: Min Woo Kang, Yong Chul Kim, Kook-Hwan Oh, Dong Ki Kim, Sehoon Park
Journal: Journal of the American Society of Nephrology (2024)
Canonical Correlation Analysis Identifies Single Nucleotide Polymorphisms and Gene Expression Associated with CKD Subtypes
Authors: Amy J. Osborne, Samantha JL Hayward, Liz Colby, Philip A. Kalra, Olivier Radresa, Philipp Skroblin, Maarten W. Taal, Gavin Iain Welsh, Moin A. Saleem, Ian Colin Campbell
Journal: Journal of the American Society of Nephrology (2024)
Association between Age and Body Mass Index in Patients with End-Stage Autosomal Dominant Polycystic Kidney Disease (ADPKD) in the United States and Japan
Authors: Tatsuya Suwabe, Vicente E. Torres, Lisa E. Vaughan, Charles D. Madsen, Peter C. Harris, Junichi Hoshino, Saori Nishio
Journal: Journal of the American Society of Nephrology (2024)
Prevalence and Severity of Polycystic Liver Disease (PLD) in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Authors: Taher Dehkharghanian, Mauricio Alejandro Miranda Cam, Sol Maria Carriazo Julio, Xuewen Song, Yasmina Sarie, Saima Khowaja, Timothy L. Kline, York Pei
Journal: Journal of the American Society of Nephrology (2024)
Successful Eculizumab-Based Desensitization in ABO-Incompatible Living Donor Kidney Transplantation
Authors: Ga Young Heo, Minsun Jung, Honglin Piao, Hyun-Jeong Kim, Hyung Woo Kim, Juhan Lee, Kyu ha Huh, Beom Seok Kim, Jaeseok Yang
Journal: Journal of the American Society of Nephrology (2024)
Effects of Suppressed Indoxyl Sulfate Production on Kidney Injury-Associated Cardiac Pathogenesis in Sult1a1-Deficient Mice
Authors: Aina Sugiura, Kaito Makise, Yuki Narita, Yutaka Kakizoe, Yuichiro Izumi, Takashige Kuwabara, Yuichiro Arima, Kenichi Tsujita, Hirofumi Jono, Hideyuki Saito
Journal: Journal of the American Society of Nephrology (2024)
Targeting MicroRNA-132 Decreases Kidney Fibrosis: A Role for Altered Plasticity of Cells of Renin Lineage?
Authors: Loïs van der Pluijm, Angela Koudijs, Joris I. Rotmans, Kenneth W. Gross, Anton Jan Van Zonneveld, Roel Bijkerk
Journal: Journal of the American Society of Nephrology (2024)
Results from Longer Follow-Up with Povetacicept, an Enhanced Dual BAFF/APRIL Antagonist, in IgA Nephropathy (RUBY-3 Study)
Authors: Arvind Madan, Rajesh Yalavarthy, Dong Ki Kim, Ju young Moon, Inwhee Park, Sreedhar A. Mandayam, Frank B. Cortazar, Sung Gyun Kim, Rupert Hugo Davies, Amanda M. Enstrom, Heather Thomas, Jiahua Li, Stanford L. Peng, James A. Tumlin
Journal: Journal of the American Society of Nephrology (2024)
Genetic Landscape in Population-Based ADPKD Cohort: Beyond PKD Type 1 and PKD Type 2
Authors: Nikola Zagorec, Marie-Pierre Audrezet, Jean-Michel Halimi, Frank Bridoux, Jean francois Augusto, Jacques Dantal, Yannick Le Meur, Emilie Cornec-Le Gall
Journal: Journal of the American Society of Nephrology (2024)
Unraveling the Mechanism of SGLT2 Inhibitors Using Urinary Proteomics in Patients with Diabetic Kidney Disease
Authors: Mark Andre De la Rambelje, Viji Nair, Niels Jongs, Michael K. Hansen, Adriaan A. Voors, Matthias Kretzler, Wenjun Ju, Hiddo Jan L. Heerspink
Journal: Journal of the American Society of Nephrology (2024)
Labeling of Denatured Collagen in ADPKD and Comparison to Fibrotic Area
Authors: Caroline R. Sussman, Heather L. Holmes, Mohamed Ahmed Addani, Seth M. Entriken, Damon Anthony Montgomery, Angel Maame Afua Obiorah, Vibhuti Amin, Kevin L. Webb, Deema Anaam, Diana Alzamareh, Slobodan Macura, Vicente E. Torres, Timothy L. Kline, Michael F. Romero, Peter C. Harris
Journal: Journal of the American Society of Nephrology (2024)
Spatial-omic Profiling of Human Kidney Tissues Using SeqStain Stratifies Disease Pathology
Authors: Anirudh Vattikota, Mohamed Youssef, Sowmya Gurusamy Kamaraj, Ishwarya Venkatesh, Ameera M. Shaw, David J. Cimbaluk, Vineet Gupta
Journal: Journal of the American Society of Nephrology (2024)
Predictive Value of Current KDIGO CKD Screening Criteria in Women and Men across Ethnic Groups: The HELIUS Study
Authors: Taryn G. Vosters, Vianda S. Stel, Kitty J. Jager, Liffert Vogt, Frans J. van Ittersum, Bert-jan Van den Born, Irene van Valkengoed
Journal: Journal of the American Society of Nephrology (2024)
Tamoxifen Prevents the Lithium-Induced Increased Cilium Length and Necroptosis Reduction
Authors: Mariangela Centrone, Ines Angelini, Mariagrazia D'Agostino, Annarita Di Mise, Barbara Barile, Grazia Paola Nicchia, Stine Julie Tingskov, Rikke Norregaard, Giovanna Valenti, Grazia Tamma
Journal: Journal of the American Society of Nephrology (2024)
Inhibition of D-amino Acid Metabolism May Improve Glucose Metabolism via Reduction of Insulin Resistance
Authors: Eriko Hayashi, Keisuke Sako, Kiyoaki Ito, Shinji Kitajima, Ichiro Mizushima, Norihiko Sakai, Miho Shimizu, Yasunori Iwata
Journal: Journal of the American Society of Nephrology (2024)
Genetic GLP1R Gene Expression and Kidney Disease Progression: A Mechanistic Proteome-Wide Analysis in the Million Veteran Program
Authors: Jefferson Lorenzo Triozzi, Zhihong Yu, Otis D. Wilson, Elvis Abang Akwo, Cassianne Robinson-Cohen, Talat Alp Ikizler, Ran Tao, Adriana Hung
Journal: Journal of the American Society of Nephrology (2024)
Apolipoprotein-L1 G1 Variant Contributes to Hydrocephalus but Not to Atherosclerosis
Authors: Teruhiko Yoshida, Zhi-Hong Yang, Shinji Ashida, Zu-Xi Yu, Shashi Shrivastav, Danielle A. Springer, Matthew Starost, Avi Z. Rosenberg, Alan T. Remaley, Jeffrey B. Kopp
Journal: Journal of the American Society of Nephrology (2024)
Role of Iron Sequestration in the Development of Anemia of CKD: Implications for Treatment Resistance
Authors: Chantalle A. Campbell, Jade Matthews balcombe, Hannah Glenn Federman, Heba Elsayed, Kanza Baqai, Edwin Patiño, Mary E. Choi, Oleh M. Akchurin
Journal: Journal of the American Society of Nephrology (2024)
Does CKD Modify the Effects of Glucagon-Like Peptide 1 Receptor Agonists (GLP-1 RAs) and SGLT2 Inhibitors on Weight Loss?
Authors: Shalini Kasera, Sydney Elizabeth Hartsell, Guo Wei, Ravinder Singh, Mckenna R. Nevers, Amara Sarwal, Akhil Ramanujam Chakravartula, Niharika Katkam, Srinivasan Beddhu
Journal: Journal of the American Society of Nephrology (2024)
Outcomes after Kidney Transplantation in ANCA-Associated Vasculitis
Authors: Benoit Brilland, Marine Dekervel, Priscille Traversat, Antoine Thierry, Leonard Golbin, Dominique Bertrand, Emilie Cornec-Le Gall, Giorgina B. Piccoli, Assia Ilham Djema, Nicolas Henry, Agnes Duveau, Dany Anglicheau, Valerie Chatelet Pouliquen, Sophie Caillard, Fabien Duthe, Philippe Gatault, Jean francois Augusto
Journal: Journal of the American Society of Nephrology (2024)
Accuracy of Myocardial Perfusion Imaging (MPI) in Predicting Post-transplant Cardiovascular Events among Asymptomatic Diabetic Kidney Transplant Candidates
Authors: Bilal Mohsin, Yasir Alfi, Shahad Alaydarous, Naief Mohammad S Alhowaiti, Nasser Omran Odah, Wael Taher Habhab
Journal: Journal of the American Society of Nephrology (2024)
Simultaneous Heart-Kidney Transplant Is the Best Treatment Option for Patients with CKD and ESKD vs. Heart Transplant Alone
Authors: Krutika P. Chauhan, Qingyuan Tan, Siobhan Sutcliffe, Su-Hsin Chang, Tarek Alhamad, Massini Merzkani
Journal: Journal of the American Society of Nephrology (2024)
Mortality Trends of Patients with Systemic Lupus Erythematosus on Dialysis in the Japanese Society for Dialysis Therapy (JSDT) Registry: Web-Based Analysis of Dialysis Data Archives (WADDA) System
Authors: Nanako Oshiro, Kentaro Kohagura, Kenya Kusunose, Kunitoshi Iseki
Journal: Journal of the American Society of Nephrology (2024)
Proximal Tubular Function Is Independent of Glomerular Filtration Rate
Authors: Magdalena Madero, Ana K. Fernandez Yepez, Guadalupe Monserrat Montesinos Ojeda, Alan Jan Guzmán Portillo, Aurora Itzel Estrada Escamilla, Francisco Perez Allende Perez, Bernardo Rodriguez-Iturbe
Journal: Journal of the American Society of Nephrology (2024)
Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis
Authors: Philippe Généreux, Allan Schwartz, J Bradley Oldemeyer, Philippe Pibarot, David J Cohen, Philipp Blanke, Brian R Lindman, Vasilis Babaliaros, William F Fearon, David V Daniels, Adnan K Chhatriwalla, Clifford Kavinsky, Hemal Gada, Pinak Shah, Molly Szerlip, Thom Dahle, Kashish Goel, William O'Neill, Tej Sheth, Charles J Davidson, Raj R Makkar, Heather Prince, Yanglu Zhao, Rebecca T Hahn, Jonathon Leipsic, Björn Redfors, Stuart J Pocock, Michael Mack, Martin B Leon
Journal: New England Journal of Medicine (2024)

BackgroundFor patients with asymptomatic severe aortic stenosis and preserved left ventricular ejection fraction, current guidelines recommend routine clinical surveillance every 6 to 12 months. Data from randomized trials examining whether early intervention with transcatheter aortic-valve replacement (TAVR) will improve outcomes in these patients are lacking.MethodsAt 75 centers in the United States and Canada, we randomly assigned, in a 1:1 ratio, patients with asymptomatic severe aortic stenosis to undergo early TAVR with transfemoral placement of a balloon-expandable valve or clinical surveillance. The primary end point was a composite of death, stroke, or unplanned hospitalization for cardiovascular causes. Superiority testing was performed in the intention-to-treat population.ResultsA total of 901 patients underwent randomization; 455 patients were assigned to TAVR and 446 to clinical surveillance. The mean age of the patients was 75.8 years, the mean Society of Thoracic Surgeons Predicted Risk of Mortality score was 1.8% (on a scale from 0 to 100%, with higher scores indicating a greater risk of death within 30 days after surgery), and 83.6% of patients were at low surgical risk. A primary end-point event occurred in 122 patients (26.8%) in the TAVR group and in 202 patients (45.3%) in the clinical surveillance group (hazard ratio, 0.50; 95% confidence interval, 0.40 to 0.63; P<0.001). Death occurred in 8.4% of the patients assigned to TAVR and in 9.2% of the patients assigned to clinical surveillance, stroke occurred in 4.2% and 6.7%, respectively, and unplanned hospitalization for cardiovascular causes occurred in 20.9% and 41.7%. During a median follow-up of 3.8 years, 87.0% of patients in the clinical surveillance group underwent aortic-valve replacement. There were no apparent differences in procedure-related adverse events between patients in the TAVR group and those in the clinical surveillance group who underwent aortic-valve replacement.ConclusionsAmong patients with asymptomatic severe aortic stenosis, a strategy of early TAVR was superior to clinical surveillance in reducing the incidence of death, stroke, or unplanned hospitalization for cardiovascular causes. (Funded by Edwards Lifesciences; EARLY TAVR ClinicalTrials.gov number, NCT03042104.)
Primary Care–Based Chronic Kidney Disease Management—Reply
Authors: Jorge A. Rodriguez, Chenxi Gao, Lipika Samal
Journal: JAMA (2024)

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Timing of Palliative Care Initiation and Resource Use—Are We Any Further Ahead?
Authors: Ada Hsieh, Lilian T. Gien
Journal: JAMA Network Open (2024)

Sarah J. Mah, MD, MSc; Daniel M. Carter Ramirez, MD, PhD; Kara Schnarr, MD, PhD; Lua R. Eiriksson, MD, MPH; Anastasia Gayowsky, MSc; Hsien Seow, PhD