tbuckley/cabot-search huggingface dataset:
Loss of CD20 expression as a mechanism of resistance to mosunetuzumab in relapsed/refractory B-cell lymphomas
Authors: Stephen J. Schuster, Ling-Yuh Huw, Christopher R. Bolen, Victor Maximov, Andrew G. Polson, Katerina Hatzi, Elisabeth A. Lasater, Sarit E. Assouline, Nancy L. Bartlett, L. Elizabeth Budde, Matthew J. Matasar, Hartmut Koeppen, Emily C. Piccione, Deanna Wilson, Michael C. Wei, Shen Yin, Elicia Penuel
Journal: Blood (2023)

Abstract CD20 is an established therapeutic target in B-cell malignancies. The CD20 × CD3 bispecific antibody mosunetuzumab has significant efficacy in B-cell non-Hodgkin lymphomas (NHLs). Because target antigen loss is a recognized mechanism of resistance, we evaluated CD20 expression relative to clinical response in patients with relapsed and/or refractory NHL in the phase 1/2 GO29781 trial investigating mosunetuzumab monotherapy. CD20 was studied using immunohistochemistry (IHC), RNA sequencing, and whole-exome sequencing performed centrally in biopsy specimens collected before treatment at predose, during treatment, or upon progression. Before treatment, most patients exhibited a high proportion of tumor cells expressing CD20; however, in 16 of 293 patients (5.5%) the proportion was &amp;lt;10%. Analyses of paired biopsy specimens from patients on treatment revealed that CD20 levels were maintained in 29 of 30 patients (97%) vs at progression, where CD20 loss was observed in 11 of 32 patients (34%). Reduced transcription or acquisition of truncating mutations explained most but not all cases of CD20 loss. In vitro modeling confirmed the effects of CD20 variants identified in clinical samples on reduction of CD20 expression and missense mutations in the extracellular domain that could block mosunetuzumab binding. This study expands the knowledge about the occurrence of target antigen loss after anti-CD20 therapeutics to include CD20-targeting bispecific antibodies and elucidates mechanisms of reduced CD20 expression at disease progression that may be generalizable to other anti-CD20 targeting agents. These results also confirm the utility of readily available IHC staining for CD20 as a tool to inform clinical decisions. This trial was registered at www.ClinicalTrials.gov as #NCT02500407.
Gastroenterology training in Africa: an assessment of curriculum and perception
Authors: Nkengeh Tazinkeng, Joao Filipe G Monteiro, Sandie R Thomson, Yakira David, Ahmad Madkour, Leolin Katsidzira, Elly Ogutu, Mary Afihene, Hailemichael Desalegn, Evaristus S Chukwudike, Ayooluwatomiwa D Adekunle, Olusegun Isaac Alatise, Ganiyat Oyeleke, Akwi W Asombang
Journal: The Lancet. Gastroenterology & hepatology (2023)
Evaluating the safety, tolerability, and immunogenicity of a 24-valent pneumococcal conjugate vaccine (VAX-24) in healthy adults aged 18 to 64 years: a phase 1/2, double-masked, dose-finding, active-controlled, randomised clinical trial
Authors: James Wassil, Maggie Sisti, Jeff Fairman, Matthew Davis, Carlos Fierro, Sean Bennett, Derek Johnson, Thi-Sau Migone, Kien Nguyen, Paul Sauer, Michelle Currie, Sam Iki, Jakub K Simon
Journal: The Lancet Infectious Diseases (2023)
Efficacy and safety of bempedoic acid among patients with and without diabetes: prespecified analysis of the CLEAR Outcomes randomised trial
Authors: Kausik K Ray, Stephen J Nicholls, Na Li, Michael J Louie, Danielle Brennan, A Michael Lincoff, Steven E Nissen
Journal: The Lancet Diabetes & Endocrinology (2023)

Statins reduce LDL cholesterol and cardiovascular events among those with or without diabetes but have been reported to increase new-onset diabetes. The CLEAR Outcomes trial demonstrated that bempedoic acid reduced the risk of major adverse cardiovascular events among statin-intolerant patients at high cardiovascular risk. In this prespecified analysis, our dual aims were to evaluate the cardiovascular benefits of bempedoic acid, an ATP-citrate lyase inhibitor, in individuals with diabetes, and to evaluate the risk of new-onset diabetes and HbA
Building the vector in: construction practices and the invasion and persistence of Anopheles stephensi in Jigjiga, Ethiopia
Authors: Solomon Yared, Araya Gebresilassie, Esayas Aklilu, Elyas Abdulahi, Oscar D Kirstein, Gabriela Gonzalez-Olvera, Azael Che-Mendoza, Wilbert Bibiano-Marin, Elizabeth Waymire, Jo Lines, Audrey Lenhart, Uriel Kitron, Tamar Carter, Pablo Manrique-Saide, Gonzalo M Vazquez-Prokopec
Journal: The Lancet Planetary Health (2023)

Anopheles stephensi is a major vector of malaria in Asia and the Arabian Peninsula, and its recent invasion into Africa poses a major threat to malaria control and elimination efforts on the continent. The mosquito is well adapted to urban environments, and its presence in Africa could potentially lead to an increase in malaria transmission in cities. Most of the knowledge about An stephensi ecology in Africa has been generated from studies conducted during the rainy season, when vectors are most abundant. Here, we provide evidence from the peak of the dry season in the city of Jigjiga in Ethiopia, and report An stephensi immature stages infesting predominantly in water reservoirs made to support construction operations (ie, in construction sites or associated with brick-manufacturing businesses). Political and economic changes in Ethiopia (particularly the Somali Region) have fuelled an unprecedented construction boom since 2018 that, in our opinion, has been instrumental in the establishment, persistence, and propagation of An stephensi via the year-round availability of perennial larval habitats associated with construction. We argue that larval source management during the dry season might provide a unique opportunity for focused control of An stephensi in Jigjiga and similar areas.
68Ga-DOTATATE PET to Characterize Lesions in the Neuroaxis
Authors: Katherine Hartmann, Jennifer A. Gillman, Jillian W. Lazor, Jeffrey B. Ware, Joanna K. Weeks, Ilya M. Nasrallah, Michael D. Farwell, Austin R. Pantel
Journal: Clinical Nuclear Medicine (2023)

The differentiation of paragangliomas, schwannomas, meningiomas, and other neuroaxis tumors in the head and neck remains difficult when conventional MRI is inconclusive. This study assesses the utility of 68 Ga-DOTATATE PET/CT as an adjunct to hone the diagnosis.
USPSTF recommends PrEP using effective antiretroviral therapy in adults and adolescents at high risk for HIV
Authors: Fred Arthur Zar
Journal: Annals of Internal Medicine (2023)

Source Citation US Preventive Services Task Force; Barry MJ, Nicholson WK, Silverstein M, et al. Preexposure prophylaxis to prevent acquisition of HIV: US Preventive Services Task Force Recommendation Statement. JAMA. 2023;330:736-745. 37606666
In acute MI complicated by cardiogenic shock, ECLS did not reduce 30-d all-cause mortality
Authors: Raúl Moreno
Journal: Annals of Internal Medicine (2023)

ACP Journal Club5 December 2023In acute MI complicated by cardiogenic shock, ECLS did not reduce 30-d all-cause mortalityRaúl Moreno, MD, PhDRaúl Moreno, MD, PhDUniversity Hospital, La Paz, Madrid, Spain (R.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/J23-0093 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationThiele H, Zeymer U, Akin I, et al; ECLS-SHOCK Investigators. Extracorporeal life support in infarct-related cardiogenic shock. N Engl J Med. 2023;389:1286-1297. https://pubmed.ncbi.nlm.nih.gov/37634145Clinical Impact RatingsGIM/FP/GP: Cardiology: Critical Care: References1. Hochman JS, Sleeper LA, Webb JG, et al. Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should we emergently revascularize occluded coronaries for cardiogenic shock. N Engl J Med. 1999;341:625-634. [PMID: 10460813] Google Scholar2. Thiele H, Akin I, Sandri M, et al; CULPRIT-SHOCK Investigators. One-year outcomes after PCI strategies in cardiogenic shock. N Engl J Med. 2018;379:1699-1710. [PMID: 30145971] Google Scholar3. Thiele H, Zeymer U, Neumann FJ, et al; IABP-SHOCK II Trial Investigators. Intraaortic balloon support for myocardial infarction with cardiogenic shock. N Engl J Med. 2012;367:1287-1296. [PMID: 22920912] Google Scholar4. Yannopoulos D, Bartos J, Raveendran G, et al. Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial. Lancet. 2020;396:1807-1816. [PMID: 33197396] Google Scholar Author, Article, and Disclosure InformationAuthors: Raúl Moreno, MD, PhDAffiliations: University Hospital, La Paz, Madrid, Spain (R.M.)Disclosures: The commentator has reported no disclosures of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=J23-0093.This article was published at Annals.org on 5 December 2023.ACP Journal Club is editorially independent from Annals of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics December 2023Volume 176, Issue 12 Page: JC135 Keywords Clinical trials Mortality Percutaneous coronary intervention Randomized trials Resuscitation Revascularization Shock Systolic pressure Ventricular fibrillation ePublished: 5 December 2023 Issue Published: December 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Writing letters to patients attending psychiatry clinics
Authors: Dave Martin, Katharine Weetman
Journal: BMJ (2023)

Since around 2000, there has been a shift in UK medical and surgical culture and guidelines towards including patients in written correspondence about their care. 1 UK guidelines and standards 2 -4 state that all clinical letters between physicians should be copied to the patient they concern, apart from exceptional circumstances such as the potential for patient harm or third party data breach. 2 3More recently, there has been a movement towards writing to patients directly 5 and copying in the relevant physician, for example their GP.The aim is to avoid the detachment and patronage of third person letters sent to patients. 5 -7 Writing to patients can raise concerns regarding patient's anxiety and understanding of letters, although evidence suggests that such views are largely unfounded. 7 8Evidence indicates that patients value receiving their letters and find them useful. 9 -11Furthermore, GPs find letters written to patients are more comprehensible and patient centred 5 12 13 and that the time spent explaining letters to patients is reduced by writing to patients in the first place.
Predictors of unsustained measurable residual disease negativity in patients with multiple myeloma
Authors: Mattia D’Agostino, Giuseppe Bertuglia, Delia Rota-Scalabrini, Angelo Belotti, Sonia Morè, Paolo Corradini, Stefania Oliva, Antonio Ledda, Mariella Grasso, Vincenzo Pavone, Sonia Ronconi, Iolanda Donatella Vincelli, Stelvio Ballanti, Cristina Velluti, Claudia Cellini, Alessandro Gozzetti, Angelo D. Palmas, Barbara Gamberi, Katia Mancuso, Laura Paris, Renato Zambello, Maria Teresa Petrucci, Benedetto Bruno, Pellegrino Musto, Francesca Gay
Journal: Blood (2023)
18F-FDG PET/CT Versus 68Ga-FAPI PET/CT in a Case of Isolated Nodal-Type Follicular Dendritic Cell Sarcoma
Authors: Zhuoyuan Li, Lin Qiu, Tingting Xu, Dan Su, Yue Chen
Journal: Clinical Nuclear Medicine (2023)

Follicular dendritic cell sarcoma is a rare low-grade sarcoma originating from mesenchymal dendritic cells. We presented 18 F-FDG and 68 Ga-FAPI PET/CT findings in a 32-year-old woman with pathologically confirmed nodal-type follicular dendritic cell sarcoma. In this case, follicular dendritic cell sarcoma demonstrated lower uptake with FAPI than FDG.
Transcriptional control of leukemogenesis by the chromatin reader SGF29
Authors: Karina Barbosa, Anagha Deshpande, Marlenne Perales, Ping Xiang, Rabi Murad, Akula Bala Pramod, Anna Minkina, Neil Robertson, Fiorella Schischlik, Xue Lei, Younguk Sun, Adam Brown, Diana Amend, Irmela Jeremias, John G. Doench, R. Keith Humphries, Eytan Ruppin, Jay Shendure, Prashant Mali, Peter D. Adams, Aniruddha J. Deshpande
Journal: Blood (2023)
In RA in remission for &gt;1 y, tapering TNFi to discontinuation did not meet noninferiority criteria compared with stable TNFi for disease flare at 12 mo
Authors: Francisco Ramirez Lafita
Journal: Annals of Internal Medicine (2023)

Source Citation Lillegraven S, Paulshus Sundlisaeter N, Aga AB, et al. Effect of tapered versus stable treatment with tumour necrosis factor inhibitors on disease flares in patients with rheumatoid arthritis in remission: a randomised, open label, non-inferiority trial. Ann Rheum Dis. 2023;82:1394-1403. 37607809
Clinical Implications of Adding SPECT/CT to Radioiodine Whole-Body Scan in Patients With Differentiated Thyroid Cancer
Authors: Ari Chong, Youngduk Seo, Ji-In Bang, Sohyun Park, Keunyoung Kim, Chae Moon Hong, Miyoung Choi, So Won Oh, Sang-Woo Lee
Journal: Clinical Nuclear Medicine (2023)

Purpose This study aimed to determine the usefulness of adding SPECT/CT to radioiodine whole-body scans (WBSs) for the treatment of differentiated thyroid cancer (DTC). Patients and Methods A systematic review and meta-analysis were performed following the PRISMA guidelines (PROSPERO registration: CRD42022341732) to compare the feasibility of conclusive readings and the frequency of changes in treatment plans in patients with DTC undergoing WBS + SPECT/CT versus WBS. MEDLINE, EMBASE, and Cochrane databases were searched to identify relevant articles concerning thyroid cancer, radioactive iodine, and SPECT/CT or SPECT, published before August 16, 2023. Studies not comparing WBS + SPECT/CT with WBS, those lacking target outcomes, and those not involving human subjects were excluded. The risk of bias was assessed using the RoBANS 2.0 (Risk of Bias Assessment Tool for Nonrandomized Studies) tool. The GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) system was used to evaluate the quality of evidence and strength of recommendations. Results A total of 30 studies (prospective n = 9, retrospective n = 21) were included in the meta-analyses. Adding SPECT/CT to WBS was shown to increase conclusive readings for cervical lesions, extracervical lesions, and all regions. Lesion-based analyses showed improvements of 14%, 20%, and 18%, respectively, whereas scan-based analyses showed improvements of 27%, 9%, and 34%. The addition of SPECT/CT to WBS led to changes in 30% of treatment plans after diagnostic scans and 9% of treatment plans after posttherapeutic scans. The quality of evidence and strength of recommendations were low. Conclusions Compelling evidence demonstrates that the addition of SPECT/CT to WBS improves lesion localization, diagnostic performance, and therapy plan for patients with DTC.
Ambient nitrogen dioxide in 47 187 neighbourhoods across 326 cities in eight Latin American countries: population exposures and associations with urban features
Authors: Josiah L Kephart, Nelson Gouveia, Daniel A Rodríguez, Katherine Indvik, Tania Alfaro, José Luis Texcalac-Sangrador, J Jaime Miranda, Usama Bilal, Ana V Diez Roux
Journal: The Lancet Planetary Health (2023)

Health research on ambient nitrogen dioxide (NO
Endoscopic ultrasonography-guided gastroenterostomy versus uncovered duodenal metal stenting for unresectable malignant gastric outlet obstruction (DRA-GOO): a multicentre randomised controlled trial
Authors: Anthony Yuen Bun Teoh, Sundeep Lakhtakia, Ilaria Tarantino, Manuel Perez-Miranda, Rastislav Kunda, Fauze Maluf-Filho, Vinay Dhir, Jahangeer Basha, Shannon Melissa Chan, Dario Ligresti, Mark Tsz Wah Ma, Carlos de la Serna-Higuera, Hon Chi Yip, Enders Kwok Wai Ng, Philip Wai Yan Chiu, Takao Itoi
Journal: The Lancet. Gastroenterology & hepatology (2023)
Intraoperative Radioguided Localization of an Occult Neuroendocrine Tumor of the Ileum
Authors: Gianpiero Manca, Giovanna Nonne, Duccio Volterrani
Journal: Clinical Nuclear Medicine (2023)

We report the intraoperative radioguided localization of an occult well-differentiated neuroendocrine tumor of the ileum in a patient with a known neuroendocrine lymphonodal metastasis in the mesentery. Preoperative imaging included CT, PET/CT with 68 Ga-DOTATOC, and SPECT/CT with 99m Tc-HYNICTOC. These scans revealed morphological and functional properties of the primary tumor localized in the ileum. The day after IV 99m Tc-HYNICTOC injection, the patient underwent surgery, and the target lesion was intraoperatively detected by a collimated handheld γ-probe. Postoperative pathology examination confirmed the target lesion to be a neuroendocrine tumor of the ileum.
In older adults, specialty geriatrics care, multicomponent interventions, and cognitive stimulation reduce nursing home admission
Authors: Terry Quinn
Journal: Annals of Internal Medicine (2023)

ACP Journal Club5 December 2023In older adults, specialty geriatrics care, multicomponent interventions, and cognitive stimulation reduce nursing home admissionTerry Quinn, MDTerry Quinn, MDUniversity of Glasgow, Glasgow, Scotland, UK (T.Q.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/J23-0097 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationGaugler JE, Zmora R, Peterson CM, et al. What interventions keep older people out of nursing homes? A systematic review and meta-analysis. J Am Geriatr Soc. 2023;71:3609-3621. https://pubmed.ncbi.nlm.nih.gov/37526432Clinical Impact RatingsGIM/FP/GP: Geriatrics: Public Health: References1. Rubin EB, Buehler AE, Halpern SD. States worse than death among hospitalized patients with serious illnesses. JAMA Intern Med. 2016;176:1557-1559. [PMID: 27479808] Google Scholar2. Ellis G, Gardner M, Tsiachristas A, et al. Comprehensive geriatric assessment for older adults admitted to hospital. Cochrane Database Syst Rev. 2017;9:CD006211. [PMID: 28898390] Google Scholar3. Gurwitz JH. The paradoxical decline of geriatric medicine as a profession. JAMA. 2023;330:693-694. [PMID: 37540519] Google Scholar4. Burton JK, Ciminata G, Lynch E, et al. Understanding pathways into care homes using data (UnPiCD study): a retrospective cohort study using national linked health and social care data. Age Ageing. 2022;51:afac304. [PMID: 36580557] Google Scholar Author, Article, and Disclosure InformationAuthors: Terry Quinn, MDAffiliations: University of Glasgow, Glasgow, Scotland, UK (T.Q.)Disclosures: The commentator has reported no disclosures of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=J23-0097.This article was published at Annals.org on 5 December 2023.ACP Journal Club is editorially independent from Annals of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics December 2023Volume 176, Issue 12 Page: JC138 Keywords Elderly Geriatric care Geriatrics Grading of Recommendations Assessment Development and Evaluation Health care Inpatients Nursing homes Stroke rehabilitation Systematic reviews ePublished: 5 December 2023 Issue Published: December 2023 Copyright & PermissionsCopyright © 2023 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Microcystic Serous Cystadenoma Masquerading as Pancreatic Neuroendocrine Tumor on 99mTc-HYNIC-TOC SPECT/CT
Authors: Wenjiao Cai, Yiyuan Dong, Tingting Zhao, Aisheng Dong, Qian Zhao
Journal: Clinical Nuclear Medicine (2023)

Abstract We present 99m Tc-HYNIC-TOC SPECT/CT findings in a case of microcystic serous cystadenoma of the pancreatic head. The pancreatic tumor showed intense 99m Tc-HYNIC-TOC uptake mimicking neuroendocrine tumor on SPECT/CT. This case indicates that microcystic serous cystadenoma should be included in the differential diagnosis of 99m Tc-HYNIC-TOC–avid pancreatic masses.
False Positive in [99mTc]Tc-DPD Scintigraphy for Cardiac Amyloidosis Due to Intravenous Iron Administration
Authors: Teodoro Rudolphi Solero, Manuel Feriche Aragón, Tomader Amrani Raissouni, Alberto Delgado-García, Maria José Cañada-Rodríguez, Salomé Sanz Viedma
Journal: Clinical Nuclear Medicine (2023)

Abstract [ 99m Tc]Tc-DPD (3,3-diphosphono-1,2-propanodicarboxylic acid) scintigraphy is an essential tool for diagnosing transthyretin amyloid cardiac amyloidosis. An 86-year-old woman suffering from heart failure with preserved ejection fraction underwent [ 99m Tc]Tc-DPD scintigraphy and a SPECT/CT for suspected transthyretin amyloid cardiac amyloidosis. The scan showed intracardiac and liver uptake. As the patient had taken intravenous iron on the morning of the scan, we decided to repeat the scan, but this time, it showed no uptake in the heart or the liver. Accordingly, we concluded the first result was a false positive due to drug interaction.
In older adults, postoperative oral haloperidol vs. antipsychotics was linked to similar risk for in-hospital adverse events
Authors: Kinga Kiszko, Ravishankar Ramaswamy
Journal: Annals of Internal Medicine (2023)

Source Citation Kim DH, Lee SB, Park CM, et al. Comparative safety analysis of oral antipsychotics for in-hospital adverse clinical events in older adults after major surgery: a nationwide cohort study. Ann Intern Med. 2023;176:1153-1162. 37665998
Burden of atopic dermatitis in paediatric patients: an international cross-sectional study
Authors: Stephan Weidinger, Eric L Simpson, Jonathan I Silverberg, Sebastien Barbarot, Laurent Eckert, Paola Mina-Osorio, Ana B Rossi, Lysel Brignoli, Tarek Mnif, Isabelle Guillemin, Miriam C Fenton, Dimittri Delevry, Chien-chia Chuang, Marine Pellan, Abhijit Gadkari
Journal: British Journal of Dermatology (2023)

Abstract Background Few large-scale international studies have broadly characterized the burden of atopic dermatitis (AD) across age groups among children and adolescents. Objectives To better characterize the AD burden in paediatric patients by disease severity. Methods This cross-sectional, web-based survey of paediatric patients (6 months to &amp;lt; 18 years old) was conducted in 18 countries representing North America, Latin America, Europe, Middle East/Eurasia and East Asia. Patients with diagnosed AD were identified based on the International Study of Asthma and Allergies in Childhood criteria and self-/parent-report of ever being told by a physician that they or their child had eczema. AD severity was assessed using the Patient-Oriented Eczema Measure and Patient Global Assessment. Outcomes included measures of itch, skin pain, sleep, health-related quality of life (HRQoL), missed school days and atopic comorbidities. Results The survey included 1489 children aged 6 months to &amp;lt; 6 years; 2898 children aged 6 to &amp;lt; 12 years; and 3078 adolescents aged 12 to &amp;lt; 18 years diagnosed with AD. Although the burden of mild AD was substantial, paediatric patients with moderate or severe AD had more itch, skin pain, sleep problems and impaired HRQoL, and missed more school days relative to those with mild AD; greater burden was observed among those with severe relative to moderate AD. At least one atopic comorbidity was present in 92.5% of all respondents. Conclusions These results highlight the burden of AD in paediatric patients, especially those with moderate-to-severe disease, and suggest the need for assessments that include the impact of AD on function and daily life.
Role of Advanced Practice Providers in the Cardiac Intensive Care Unit Team
Authors: Carolina D. Tennyson, Margaret T. Bowers, Allison W. Dimsdale, Sharon M. Dickinson, R. Monica Sanford, Jordan D. McKenzie-Solis, Hannah D. Schimmer, Carlos L. Alviar, Shashank S. Sinha, Jason N. Katz
Journal: Journal of the American College of Cardiology (2023)