STUDIES OF THE NITROGEN AND SULPHUR METABOLISM IN A CASE OF CYSTINURIA
Authors: G. P. Grabfield, B. Prescott
Journal: Annals of Internal Medicine (1936)

Article1 November 1936STUDIES OF THE NITROGEN AND SULPHUR METABOLISM IN A CASE OF CYSTINURIAG. P. GRABFIELD, F.A.C.P., B. PRESCOTTG. P. GRABFIELD, F.A.C.P.Search for more papers by this author, B. PRESCOTTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-5-632 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the introduction of satisfactory methods of studying the sulphur partition, a number of cases of cystinuria have been studied without, however, providing a basis for an adequate explanation of the condition. Excellent reviews1 of the cases so far studied have been published. The metabolic data are confusing and contradictory.2, 3Our purpose was to study the effects of diets high and low in sulphur on the cystine excretion in a patient with cystinuria. As will be seen this could be accomplished only indirectly. On account of the intimate connection between the nitrogen and sulphur metabolism, it was desirable to...References1. LEWIS HB: Cystinuria; a review of some recent investigations, Yale Jr. Biol. and Med., 1932, iv, 437-449. Google Scholar2. KAHNGOODRIDGE MFC: Sulphur metabolism; a review of the literature, 1926, Lea and Febiger, Philadelphia. Google Scholar3. PETERSVAN SLYKE JPDD: Quantitative clinical chemistry; Vol. I: Interpretations, 1931, Williams and Wilkins, Baltimore. Google Scholar4. LEWISLOUGH HBSA: The metabolism of sulfur; metabolic study of case of cystinuria, Jr. Biol. Chem., 1929, lxxxi, 285-297. CrossrefGoogle Scholar5. LOONEYBERGLUNDGRAVES JMHRC: Study of several cases of cystinuria, Jr. Biol. Chem., 1923, lvii, 515-531. CrossrefGoogle Scholar6. FISKE CH: Determination of inorganic sulfate, total sulfate and total sulfur in urine by benzidine method, Jr. Biol. Chem., 1921, xlvii, 59. CrossrefGoogle Scholar7. FOLIN O: A laboratory manual of biological chemistry, with supplement, 1922, D. Appleton, New York. Google Scholar8. LOONEY JM: The colorimetric estimation of cystine in urine, Jr. Biol. Chem., 1922, liv, 171-175. CrossrefGoogle Scholar9. LEWIS HB: Personal communications to the authors. Google Scholar10. LUGG JW: Sullivan's reaction for the quantitative determination of cysteine and cystine, Biochem. Jr., 1933, xxvii, 668. CrossrefGoogle Scholar11. ROBISON R: The value of gelatin in relation to the nitrogen requirements of man, Biochem. Jr., 1922, xvi, 111. CrossrefGoogle Scholar12. WILSON HE: The relation between sulphur and nitrogen metabolism, Biochem. Jr., 1925, xix, 322. CrossrefGoogle Scholar13. FOLIN O: A colorimetric determination of the amino-acid nitrogen in normal urine, Jr. Biol. Chem., 1922, li, 393-394. CrossrefGoogle Scholar14. LICHTMAN SS: Origin and significance of tyrosinuria in disease of the liver, Arch. Int. Med., 1934, liii, 680-688. CrossrefGoogle Scholar15. KREBS HA: Untersuchungen über den Stoffwechsel der Aminosäuren im Tierkörper, Ztschr. f. physiol. Chem., 1933, ccxvii, 191-227. KREBS, H. A.: Weitere Untersuchungen über den Abbau der Aminosäuren im Tierkörper, Ztschr. f. physiol. Chem., 1933, ccxviii, 157-159. CrossrefGoogle Scholar16. NASHBENEDICT TPSR: The ammonia content of the blood and its bearing on the mechanism of acid neutralization in the animal organism, Jr. Biol. Chem., 1921, xlviii, 463. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication July 3, 1936.From the Medical Clinic of the Peter Bent Brigham Hospital.This study was aided by a grant from the Proctor Fund for the study of Chronic Diseases, of Harvard University. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1936Volume 10, Issue 5Page: 632-638KeywordsDietExcretionHospitalsNitrogen metabolism ePublished: 1 December 2008 Issue Published: 1 November 1936 PDF downloadLoading ...