tbuckley/cabot-search huggingface dataset:
Single‐Response Duplexing of Electrochemical Label‐Free Biosensor from the Same Tag
Authors: Juliana N. Y. Costa, Gabriel J. C. Pimentel, Júlia A. Poker, Leandro Merces, Waldemir J. Paschoalino, Luis C. S. Vieira, Ana C. H. Castro, Wendel A. Alves, Lucas B. Ayres, Lauro T. Kubota, Murilo Santhiago, Carlos D. Garcia, Maria H. O. Piazzetta, Angelo L. Gobbi, Flávio M. Shimizu, Renato S. Lima
Journal: Advanced Healthcare Materials (2024)

Abstract Multiplexing is a valuable strategy to boost throughput and improve clinical accuracy. Exploiting the vertical, meshed design of reproducible and low‐cost ultra‐dense electrochemical chips, the unprecedented single‐response multiplexing of typical label‐free biosensors is reported. Using a cheap, handheld one‐channel workstation and a single redox probe, that is, ferro/ferricyanide, the recognition events taking place on two spatially resolved locations of the same working electrode can be tracked along a single voltammetry scan by collecting the electrochemical signatures of the probe in relation to different quasi‐reference electrodes, Au (0 V) and Ag/AgCl ink (+0.2 V). This spatial isolation prevents crosstalk between the redox tags and interferences over functionalization and binding steps, representing an advantage over the existing non‐spatially resolved single‐response multiplex strategies. As proof of concept, peptide‐tethered immunosensors are demonstrated to provide the duplex detection of COVID‐19 antibodies, thereby doubling the throughput while achieving 100% accuracy in serum samples. The approach is envisioned to enable broad applications in high‐throughput and multi‐analyte platforms, as it can be tailored to other biosensing devices and formats.
Arginine-assembly as NO nano-donor prevents the negative feedback of macrophage repolarization by mitochondrial dysfunction for cancer immunotherapy
Authors: Xiao Zheng, Ying Liu, Yiqiong Liu, Jie Zang, Kun Wang, Zichen Yang, Nana Chen, Jiuyuan Sun, Li Huang, Yan Li, Liangyi Xue, Hui Zhi, Xiaoyou Zhang, Min Yu, Shiyu Chen, Haiqing Dong, Yongyong Li
Journal: Biomaterials (2024)
Asynchronous direct to patient teledermatology visits (e-visits) during COVID-19 pandemic: Lessons for future teledermatology practice
Authors: Nicole Trupiano, Rebecca H Goldberg, Madison Novice, Jianheng Mai, Haihan Zhang, Sruthi Renati, Mari Paz Castanedo-Tardan, Trilokraj Tejasvi
Journal: Journal of the American Academy of Dermatology (2024)
Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application
Authors: Helena Vilaça-Faria, Jennifer Noro, Rui L. Reis, Rogério P. Pirraco
Journal: Bioactive Materials (2024)

Biomaterial choice is an essential step during the development tissue engineering and regenerative medicine (TERM) applications. The selected biomaterial must present properties allowing the physiological-like recapitulation of several processes that lead to the reestablishment of homeostatic tissue or organ function. Biomaterials derived from the extracellular matrix (ECM) present many such properties and their use in the field has been steadily increasing. Considering this growing importance, it becomes imperative to provide a comprehensive overview of ECM biomaterials, encompassing their sourcing, processing, and integration into TERM applications. This review compiles the main strategies used to isolate and process ECM-derived biomaterials as well as different techniques used for its characterization, namely biochemical and chemical, physical, morphological, and biological. Lastly, some of their applications in the TERM field are explored and discussed.
Functional specificity of recurrent inhibition in visual cortex
Authors: Petr Znamenskiy, Mean-Hwan Kim, Dylan R. Muir, M. Florencia Iacaruso, Sonja B. Hofer, Thomas D. Mrsic-Flogel
Journal: Neuron (2024)

In the neocortex, neural activity is shaped by the interaction of excitatory and inhibitory neurons, defined by the organization of their synaptic connections. Although connections among excitatory pyramidal neurons are sparse and functionally tuned, inhibitory connectivity is thought to be dense and largely unstructured. By measuring in vivo visual responses and synaptic connectivity of parvalbumin-expressing (PV+) inhibitory cells in mouse primary visual cortex, we show that the synaptic weights of their connections to nearby pyramidal neurons are specifically tuned according to the similarity of the cells' responses. Individual PV+ cells strongly inhibit those pyramidal cells that provide them with strong excitation and share their visual selectivity. This structured organization of inhibitory synaptic weights provides a circuit mechanism for tuned inhibition onto pyramidal cells despite dense connectivity, stabilizing activity within feature-specific excitatory ensembles while supporting competition between them.
Improved nationwide survival of sarcoma patients with a network of reference centers
Authors: J.Y. Blay, N. Penel, T. Valentin, P. Anract, F. Duffaud, A. Dufresne, B. Verret, A. Cordoba, A. Italiano, M. Brahmi, C. Henon, T. Amouyel, I. Ray-Coquard, G. Ferron, P. Boudou-Rouquette, C. Tlemsani, S. Salas, R. Rochwerger, M. Faron, E. Bompas, A. Ducassou, D. Gangloff, F. Gouin, N. Firmin, S. Piperno-Neumann, M. Rios, M. Ropars, J.E. Kurtz, L.R. Le Nail, F. Bertucci, S. Carrere, C. Llacer, S. Watson, S. Bonvalot, A. Leroux, C. Perrin, J. Gantzer, M. Pracht, B. Narciso, A. Monneur, C. Lebbe, A. Hervieu, E. Saada-Bouzid, P. Dubray-Longeras, F. Fiorenza, L. Chaigneau, Z.-M. Nevieres, P. Soibinet, O. Bouché, C. Guillemet, J.P. Spano, J.C. Ruzic, N. Isambert, G. Vaz, P. Meeus, M. Karanian, C. Ngo, J.M. Coindre, G. De Pinieux, F. Le Loarer, F. Ducimetiere, C. Chemin, M. Morelle, M. Toulmonde, A. Le Cesne
Journal: Annals of Oncology (2024)

We investigated the impact of the implementation of a network of reference centers for sarcomas (NETSARC) on the care and survival of sarcoma patients in France since 2010.
Hypoxia-activated cascade nanovaccine for synergistic chemoembolization-immune therapy of hepatocellular carcinoma
Authors: Qin Shi, Wen Zhang, Yongjie Zhou, Songjiang Huang, Jiaze Yu, Minjie Yang, Zihan Zhang, Jingqin Ma, Jianjun Luo, Shengxiang Rao, Daru Lu, Shaojun Peng, Yongbin Cao, Lingxiao Liu, Zhiping Yan
Journal: Biomaterials (2024)
MAFF confers vulnerability to cisplatin-based and ionizing radiation treatments by modulating ferroptosis and cell cycle progression in lung adenocarcinoma
Authors: Jiaqi Liang, Guoshu Bi, Yiwei Huang, Guangyin Zhao, Qihai Sui, Huan Zhang, Yunyi Bian, Jiacheng Yin, Qun Wang, Zhencong Chen, Cheng Zhan
Journal: Drug Resistance Updates (2024)
Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer
Authors: E. Harvey-Jones, M. Raghunandan, L. Robbez-Masson, L. Magraner-Pardo, T. Alaguthurai, A. Yablonovitch, J. Yen, H. Xiao, R. Brough, J. Frankum, F. Song, J. Yeung, T. Savy, A. Gulati, J. Alexander, H. Kemp, C. Starling, A. Konde, R. Marlow, M. Cheang, P. Proszek, M. Hubank, M. Cai, J. Trendell, R. Lu, R. Liccardo, N. Ravindran, A. Llop-Guevara, O. Rodriguez, J. Balmana, N. Lukashchuk, M. Dorschner, L. Drusbosky, I. Roxanis, V. Serra, S. Haider, S.J. Pettitt, C.J. Lord, A.N.J. Tutt
Journal: Annals of Oncology (2024)

Resistance to therapies that target homologous recombination deficiency (HRD) in breast cancer limits their overall effectiveness. Multiple, preclinically validated, mechanisms of resistance have been proposed, but their existence and relative frequency in clinical disease are unclear, as is how to target resistance.
A universal biventricular coordinate system incorporating valve annuli: Validation in congenital heart disease
Authors: Lisa R Pankewitz, Kristian G Hustad, Sachin Govil, James C Perry, Sanjeet Hegde, Renxiang Tang, Jeffrey H Omens, Alistair A Young, Andrew D McCulloch, Hermenegild J Arevalo
Journal: Medical Image Analysis (2024)
Instrumental assessment of sleep bruxism: A systematic review and meta-analysis
Authors: Rosana Cid-Verdejo, Camilo Chávez Farías, Oliver Martínez-Pozas, Erika Meléndez Oliva, Juan Nicolás Cuenca-Zaldívar, Ignacio Ardizone García, Francisco J. Martínez Orozco, Eleuterio A. Sánchez Romero
Journal: Sleep Medicine Reviews (2024)

This systematic review and meta-analysis (MA) aimed to evaluate the diagnostic validity of portable electromyography (EMG) diagnostic devices compared to the reference standard method polysomnography (PSG) in assessing sleep bruxism. This systematic review was completed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement and was registered with PROSPERO prior to the accomplishment of the main search. Ten clinical studies on humans, assessing the diagnostic accuracy of portable instrumental approaches with respect to PSG, were included in the review. Methodological shortcomings were identified by QUADAS-2 quality assessment. The certainty of the evidence analysis was established by different levels of evidence according to the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework. A meta-analysis of diagnostic test accuracy was performed with multiple thresholds per study applying a two-stage random effects model, using the thresholds offered by the studies and based on the number of EMG bruxism events per hour presented by the participants. Five studies were included. The MA indicated that portable EMG diagnostic devices showed a very good diagnostic capacity, although a high variability is evident in the studies with some outliers. Very low quality of evidence due to high risk of bias and high heterogeneity among included studies suggests that portable devices have shown high sensitivity and specificity when diagnosing sleep bruxism (SB) compared to polysomnography. The tests performed in the MA found an estimated optimal cut-off point of 7 events/hour of SB with acceptably high sensitivity and specificity.
Optic neuropathy in high myopia: Glaucoma or high myopia or both?
Authors: Xiulan Zhang, Jingwen Jiang, Kangjie Kong, Fei Li, Shida Chen, Peiyuan Wang, Yunhe Song, Fengbin Lin, Timothy P.H. Lin, Linda M. Zangwill, Kyoko Ohno-Matsui, Jost B. Jonas, Robert N. Weinreb, Dennis S.C. Lam
Journal: Progress in Retinal and Eye Research (2024)
UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas
Authors: Shiqin Liu, Timothy Chai, Fernando Garcia-Marques, Qingqing Yin, En-Chi Hsu, Michelle Shen, Angus Martin Shaw Toland, Abel Bermudez, Alifiani B. Hartono, Christopher F. Massey, Chung S. Lee, Liwei Zheng, Maya Baron, Caden J. Denning, Merve Aslan, Holly M. Nguyen, Rosalie Nolley, Amina Zoubeidi, Millie Das, Christian A. Kunder, Brooke E. Howitt, H. Tom Soh, Irving L. Weissman, Michael A. Liss, Arnold I. Chin, James D. Brooks, Eva Corey, Sharon J. Pitteri, Jiaoti Huang, Tanya Stoyanova
Journal: Cell Reports Medicine (2024)

Neuroendocrine carcinomas, such as neuroendocrine prostate cancer and small-cell lung cancer, commonly have a poor prognosis and limited therapeutic options. We report that ubiquitin carboxy-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme, is elevated in tissues and plasma from patients with neuroendocrine carcinomas. Loss of UCHL1 decreases tumor growth and inhibits metastasis of these malignancies. UCHL1 maintains neuroendocrine differentiation and promotes cancer progression by regulating nucleoporin, POM121, and p53. UCHL1 binds, deubiquitinates, and stabilizes POM121 to regulate POM121-associated nuclear transport of E2F1 and c-MYC. Treatment with the UCHL1 inhibitor LDN-57444 slows tumor growth and metastasis across neuroendocrine carcinomas. The combination of UCHL1 inhibitors with cisplatin, the standard of care used for neuroendocrine carcinomas, significantly delays tumor growth in pre-clinical settings. Our study reveals mechanisms of UCHL1 function in regulating the progression of neuroendocrine carcinomas and identifies UCHL1 as a therapeutic target and potential molecular indicator for diagnosing and monitoring treatment responses in these malignancies.
TCT-470 Long-Term Impact of Intracoronary Imaging for Percutaneous Coronary Intervention on Unprotected Left Main—IMPACTUS LM-PCI Study: An Observational, Multicentric Study
Authors: Andrea Sardone, Francesco Bruno, Fabrizio D'Ascenzo, Piera Capranzano, Giacomo Boccuzzi, Salvatore Colangelo, Francesco Colombo, Mario Iannaccone
Journal: Journal of the American College of Cardiology (2023)
TCT-468 Outcomes of Early Coronary Reperfusion After Resuscitated Out-of-Hospital Cardiac Arrest
Authors: Lap Tin Lam, Shayna Chotai, Roman Roy, Muhamad Abd Razak, Huda Abu-Own, Aleksandra Parczewska, Ian Webb, Rafal Dworakowski, Narbeh Melikian, Ajay Shah, Jonathan Byrne, Philip MacCarthy, Nilesh Pareek
Journal: Journal of the American College of Cardiology (2023)
The urgency of identifying global priorities for hearing loss prevention
Authors: Alessandra Giannella Samelli, Carla Gentile Matas
Journal: The Lancet Global Health (2024)

The effect of hearing loss throughout the life course is well understood: it can negatively affect many individual and societal aspects. When hearing loss is not identified early or there is no effective intervention, it can affect communication, spoken language development, educational attainment, social interaction, cognitive function, and overall quality of life, besides its costs for the individual and society.1,2 Global estimates have indicated that more than 5% of the population have moderate hearing loss or worse, and approximately 90% of these people live in low-income and middle-income countries, which often do not have the physical, economic, and human resources to address hearing loss.
A transferable in-silico augmented ischemic model for virtual myocardial perfusion imaging and myocardial infarction detection
Authors: Zeus Harnod, Chen Lin, Hui-Wen Yang, Zih-Wen Wang, Han-Luen Huang, Tse-Yu Lin, Chun-Yao Huang, Lian-Yu Lin, Hsu-Wen V. Young, Men-Tzung Lo
Journal: Medical Image Analysis (2024)

This paper proposes an innovative approach to generate a generalized myocardial ischemia database by modeling the virtual electrophysiology of the heart and the 12-lead electrocardiography projected by the in-silico model can serve as a ready-to-use database for automatic myocardial infarction/ischemia (MI) localization and classification. Although the virtual heart can be created by an established technique combining the cell model with personalized heart geometry to observe the spatial propagation of depolarization and repolarization waves, we developed a strategy based on the clinical pathophysiology of MI to generate a heterogeneous database with a generic heart while maintaining clinical relevance and reduced computational complexity. First, the virtual heart is simplified into 11 regions that match the types and locations, which can be diagnosed by 12-lead ECG; the major arteries were divided into 3–5 segments from the upstream to the downstream based on the general anatomy. Second, the stenosis or infarction of the major or minor coronary artery branches can cause different perfusion drops and infarct sizes. We simulated the ischemic sites in different branches of the arteries by meandering the infarction location to elaborate on possible ECG representations, which alters the infraction’s size and changes the transmembrane potential (TMP) of the myocytes associated with different levels of perfusion drop. A total of 8190 different case combinations of cardiac potentials with ischemia and MI were simulated, and the corresponding ECGs were generated by forward calculations. Finally, we trained and validated our in-silico database with a sparse representation classification (SRC) and tested the transferability of the model on the real-world Physikalisch Technische Bundesanstalt (PTB) database. The overall accuracies for localizing the MI region on the PTB data achieved 0.86, which is only 2% drop compared to that derived from the simulated database (0.88). In summary, we have shown a proof-of-concept for transferring an in-silico model to real-world database to compensate for insufficient data.
Highly active probiotic hydrogels matrixed on bacterial EPS accelerate wound healing via maintaining stable skin microbiota and reducing inflammation
Authors: Hongtao Xu, Yaqian Li, Jiangping Song, Liuyang Zhou, Kaizhang Wu, Xingyu Lu, XiaoNing Zhai, Zhili Wan, Jie Gao
Journal: Bioactive Materials (2024)

Skin microbiota plays an important role in wound healing, but skin injuries are highly susceptible to wound infections, leading to disruption of the skin microbiota. However, conventional antibacterial hydrogels eliminate both probiotics and pathogenic bacteria, disrupting the balance of the skin microbiota. Therefore, it is important to develop a wound dressing that can fend off foreign pathogenic bacteria while preserving skin microbiota stability. Inspired by live bacteria therapy, we designed a probiotic hydrogel (HAEPS@
Cost-effectiveness of system-level mental health strategies for young people in the Australian Capital Territory: a dynamic simulation modelling study
Authors: Paul Crosland, Nicholas Ho, Seyed Hossein Hosseini, Catherine Vacher, Adam Skinner, Andrea N Natsky, Sebastian Rosenberg, Raphael Hasudungan, Sam Huntley, Yun Ju Christine Song, Grace Yeeun Lee, Deborah A Marshall, Jo-An Occhipinti, Ian B Hickie
Journal: The Lancet Psychiatry (2024)
Priorities for hearing loss prevention and estimates of global cause-specific burdens of hearing loss: a systematic rapid review
Authors: Kavita Prasad, Ethan D Borre, Lauren K Dillard, Austin Ayer, Carolina Der, Kathleen E Bainbridge, Catherine M McMahon, Debara L Tucci, Blake S Wilson, Gillian D Sanders Schmidler, James Saunders
Journal: The Lancet Global Health (2024)

BackgroundHearing loss affects approximately 1·6 billion individuals worldwide. Many cases are preventable. We aimed to estimate the annual number of new hearing loss cases that could be attributed to meningitis, otitis media, congenital rubella syndrome, cytomegalovirus, and ototoxic medications, specifically aminoglycosides, platinum-based chemotherapeutics, and antimalarials.MethodsWe used a targeted and a rapid systematic literature review to calculate yearly global incidences of each cause of hearing loss. We estimated the prevalence of hearing loss for each presumed cause. For each cause, we calculated the global number of yearly hearing loss cases associated with the exposure by multiplying the estimated exposed population by the prevalence of hearing loss associated with the exposure, accounting for mortality when warranted.FindingsAn estimated 257·3 million people per year are exposed to these preventable causes of hearing loss, leading to an estimated 33·8 million new cases of hearing loss worldwide per year. Most hearing loss cases were among those with exposure to ototoxic medications (19·6 million [range 12·6 million–27·9 million] from short-course aminoglycoside therapy and 12·3 million from antimalarials). We estimated that 818 000 cases of hearing loss were caused by otitis media, 346 000 by meningitis, 114 000 by cytomegalovirus, and 59 000 by congenital rubella syndrome.InterpretationThe global burden of preventable hearing loss is large. Hearing loss that is attributable to disease sequelae or ototoxic medications contributes substantially to the global burden of hearing loss. Prevention of these conditions should be a global health priority.FundingThe US National Institute on Deafness and Other Communication Disorders and the US National Institute on Aging.
Latent viral infections as neglected risk factors for long COVID
Authors: Amir Abdoli, Ali Taghipour, Mirza Ali Mofazzal Jahromi, Fatemeh Eftekharian, Reza Sahraei, Mohammad Sadegh Sanie
Journal: The Lancet Global Health (2024)

Sophie Müller and colleagues (November, 2023)1Müller SA Isaaka L Mumm R et al.Prevalence and risk factors for long COVID and post-COVID-19 condition in Africa: a systematic review.Lancet Glob Health. 2023; 11: e1713-e1724Summary Full Text Full Text PDF PubMed Scopus (0) Google Scholar summarised data from 24 articles reporting on 9712 patients from eight African countries. Their results showed a positive association between long COVID and older age, female sex, low level of education, non-Black ethnicity, and the severity of acute infection and underlying illnesses. Tuberculosis and HIV were not recognised as risk factors.1Müller SA Isaaka L Mumm R et al.Prevalence and risk factors for long COVID and post-COVID-19 condition in Africa: a systematic review.Lancet Glob Health. 2023; 11: e1713-e1724Summary Full Text Full Text PDF PubMed Scopus (0) Google Scholar Other reports have shown that reactivation of latent infections, including with Epstein-Barr virus, cytomegalovirus, herpes simplex virus, and varicella zoster virus, could be involved in long COVID and post-COVID-19 condition.2Peluso MJ Deveau T-M Munter SE et al.Chronic viral coinfections differentially affect the likelihood of developing long COVID.J Clin Invest. 2023; 133: e163669Google Scholar, 3Gupta S Dutta A Chakraborty U Kumar R Das D Ray BK Post-COVID-19 HSV encephalitis: a review.QJM. 2022; 115: 222-227Google Scholar, 4Chen YC Ho CH Liu TH et al.Long-term risk of herpes zoster following COVID-19: a retrospective cohort study of 2 442 686 patients.J Med Virol. 2023; 95: e28745Google Scholar Notably, the association between Epstein-Barr virus reactivation and long-COVID fatigue has been reported in most studies. Long COVID is a multisystem condition with a wide range of clinical symptoms. Although the pathophysiological mechanisms of long COVID are unclear, long-lasting inflammatory mechanisms have been proposed as one of the main culprits. Chronic dysregulation of the immune system due to viral persistence and reactivation of latent viruses (eg, Epstein-Barr virus, herpes simplex virus, human herpes virus 6, cytomegalovirus, and varicella zoster virus) results in low-grade inflammation and consequently multiple organ dysfunction in long COVID.5Castanares-Zapatero D Chalon P Kohn L et al.Pathophysiology and mechanism of long COVID: a comprehensive review.Ann Med. 2022; 54: 1473-1487Crossref PubMed Scopus (176) Google Scholar Collectively, it is suggested that latent viral infections should be considered as a causal factor of long COVID and post-COVID condition. Programmes for screening and prophylaxis could be considered for these conditions. We declare no competing interests.