tbuckley/cabot-search huggingface dataset:
Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders
Authors: Zhen Xia, Qihan Jin, Zhilin Long, Yexuan He, Fuyi Liu, Chengfang Sun, Jinyang Liao, Chun Wang, Chentong Wang, Jian Zheng, Weixi Zhao, Tianxin Zhang, Jeremy N. Rich, Yongdeng Zhang, Longxing Cao, Qi Xie
Journal: Nature Biomedical Engineering (2024)
Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs
Authors: Sena Ardicli, Ozge Ardicli, Duygu Yazici, Yagiz Pat, Huseyn Babayev, Peng Xiong, Can Zeyneloglu, Asuncion Garcia‐Sanchez, Li‐Li Shi, Oliva Giannelli Viscardi, Stephen Skolnick, Ismail Ogulur, Raja Dhir, Marek Jutel, Ioana Agache, Jozef Janda, Isabella Pali‐Schöll, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis
Journal: Allergy (2024)

Abstract Since the 1960s, more than 350,000 new chemicals have been introduced into the lives of humans and domestic animals. Many of them have become part of modern life and some are affecting nature as pollutants. Yet, our comprehension of their potential health risks for both humans and animals remains partial. The “epithelial barrier theory” suggests that genetic predisposition and exposure to diverse factors damaging the epithelial barriers contribute to the emergence of allergic and autoimmune conditions. Impaired epithelial barriers, microbial dysbiosis, and tissue inflammation have been observed in a high number of mucosal inflammatory, autoimmune and neuropsychiatric diseases, many of which showed increased prevalence in the last decades. Pets, especially cats and dogs, share living spaces with humans and are exposed to household cleaners, personal care products, air pollutants, and microplastics. The utilisation of cosmetic products and food additives for pets is on the rise, unfortunately, accompanied by less rigorous safety regulations than those governing human products. In this review, we explore the implications of disruptions in epithelial barriers on the well‐being of companion animals, drawing comparisons with humans, and endeavour to elucidate the spectrum of diseases that afflict them. In addition, future research areas with the interconnectedness of human, animal, and environmental well‐being are highlighted in line with the “One Health” concept.
Antiviral Therapy for Chronic Hepatitis B with Mildly Elevated Aminotransferase: A Rollover Study from the TORCH-B Trial
Authors: Yao-Chun Hsu, Chi-Yi Chen, Cheng-Hao Tseng, Chieh-Chang Chen, Teng-Yu Lee, Ming-Jong Bair, Jyh-Jou Chen, Yen-Tsung Huang, I-Wei Chang, Chi-Yang Chang, Chun-Ying Wu, Ming-Shiang Wu, Lein-Ray Mo, Jaw-Town Lin
Journal: Clinical and Molecular Hepatology (2024)

Treatment indications for patients with chronic hepatitis B (CHB) remain contentious, particularly for patients with mild alanine aminotransferase (ALT) elevation. We aimed to evaluate treatment effects in this patient population.
Systemic Sclerosis dermal fibroblast exosomes trigger a Type 1 interferon response in keratinocytes through the <scp>TBK</scp>/<scp>JAK</scp>/<scp>STAT</scp> signalling axis
Authors: Jessica Bryon, Christopher W Wasson, Katja Koeppen, Francesca Chandler, Leon F Willis, Stefano Di Donato, Elliott Klein, Elton Zeqiraj, Rebecca L Ross, Francesco Del Galdo
Journal: Arthritis & Rheumatology (2024)

Background Activation of Type I IFN response has been shown to correlates with disease activity in systemic sclerosis. It is currently unknown whether the tissue‐specific Type I IFN activation is a consequence of the response observed in blood or rather its source. Exosomes from SSc fibroblasts were recently shown to activate macrophages in vitro . Here, we aimed to determine the source of Type I IFN signature in SSc skin biopsies and the potential role of exosomes from SSc dermal fibroblasts in the process. Methods Skin biopsies were obtained from healthy and SSc patients’ forearms and processed for dermal fibroblasts and keratinocytes. Exosomes were isolated from healthy and SSc dermal fibroblast supernatants by ultracentrifugation and added to human skin keratinocytes. Keratinocyte transcriptome was analysed by RNA‐seq analysis. TANK‐binding kinase (TBK) and JAK were inhibited using a small molecule inhibitor (GSK8612) and Tofacitinib, respectively. Results SSc skin biopsies showed highest levels of Type I IFN response in the epidermal layer. RNA‐seq analysis of keratinocytes transcriptome following exposure to dermal fibroblast exosomes showed strong upregulation of IFN signature genes induced by SSc exosomes compared to Healthy control. Inhibition of TBK or JAK activity suppressed the upregulation of the IFN signature induced by SSc exosomes. Conclusion IFN activation of SSc keratinocytes is dependent on their crosstalk with dermal fibroblasts and inducible by extracellular exosomes. Our data indicates that SSc fibroblasts exosomes contributes to theType I IFN activation in SSc skin through activation of pattern recognition receptors upstream of TBK.
Correction: Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance
Authors: Léa Montégut, Peng Liu, Liwei Zhao, María Pérez-Lanzón, Hui Chen, Misha Mao, Shuai Zhang, Lisa Derosa, Julie Le Naour, Flavia Lambertucci, Silvia Mingoia, Uxía Nogueira-Recalde, Rafael Mena-Osuna, Irene Herranz-Montoya, Nabil Djouder, Sylvain Baulande, Hui Pan, Adrien Joseph, Meriem Messaoudene, Bertrand Routy, Marine Fidelle, Tarek Ben Ahmed, Olivier Caron, Pierre Busson, David Boulate, Mélanie Deschasaux-Tanguy, Nathalie Arnault, Jonathan G Pol, Eliane Piaggio, Mathilde Touvier, Laurence Zitvogel, Suzette Delaloge, Isabelle Martins, Guido Kroemer
Journal: Molecular Cancer (2024)
Role of DOCK8 in Cytokine Storm Syndromes
Authors: Mingce Zhang, Remy R Cron, Niansheng Chu, Junior Nguyen, Scott M Gordon, Esraa M Eloseily, T Prescott Atkinson, Peter Weiser, Mark R Walter, Portia A Kreiger, Scott W Canna, Edward M Behrens, Randy Q Cron
Journal: Journal of Allergy and Clinical Immunology (2024)
Sustained hair regrowth with continued ritlecitinib treatment through Week 48 in patients with alopecia areata with or without early target responses: post hoc analysis of the ALLEGRO phase 2b/3 trial
Authors: Melissa Piliang, Charles Lynde, Brett King, Paradi Mirmirani, Rodney Sinclair, Maryanne Senna, Seth Forman, Lindsey Bordone, Pablo De La Cueva Dobao, Robert Wolk, Samuel H Zwillich, Helen Tran, Dalia Wajsbrot, Haytham Mohamed Ahmed, Liza Takiya
Journal: Journal of the American Academy of Dermatology (2024)
The Role of Sirtuin 1 in Ageing and Neurodegenerative Disease: A Molecular Perspective
Authors: Riya Thapa, Ehssan Moglad, Muhammad Afzal, Gaurav Gupta, Asif Ahmad Bhat, Waleed Hassan Almalki, Imran Kazmi, Sami I Alzarea, Kumud Pant, Thakur Gurjeet Singh, Sachin Kumar Singh, Haider Ali
Journal: Ageing Research Reviews (2024)
Breaking new ground on human health and well-being with epigenetic clocks: A systematic review and meta-analysis of epigenetic age acceleration associations
Authors: Olga Chervova, Kseniia Panteleeva, Elizabeth Chernysheva, Tyas Arum Widayati, Žan Florjanic Baronik, Natálie Hrbková, Jadesada Louis Schneider, Martin Bobak, Stephan Beck, Vitaly Voloshin
Journal: Ageing Research Reviews (2024)
Hyperfunctional T cell responses unchecked by regulatory T cells are unable to resolve hepaciviral infection without humoral contribution
Authors: Fengzhi Jin, John Gridley, Anuradha Kumari, Alireza Saeidi, Brantley Holland, Elizabeth Elrod, Piyush Dravid, Sheetal Trivedi, Amit Kapoor, Manoj Thapa, Arash Grakoui
Journal: Journal of Hepatology (2024)
<i>Cyphellophora ludoviensis</i>: A new causative species of tinea nigra
Authors: Chang Hyun Son, Sun Mun Jeong, Jang Hwan Jung, Do Ik Kwon, Seol Hwa Seong, Kee Suck Suh, Min Soo Jang
Journal: British Journal of Dermatology (2024)

A case of tinea nigra caused by Cyphellophora ludoviensis.
Overtreatment of dysplastic naevi: results of a multiregional UK questionnaire study
Authors: Fazleenah A Hussain, Arti Bakshi, Paul D Yesudian, Stuart N Cohen
Journal: British Journal of Dermatology (2024)

Journal Article Accepted manuscript Overtreatment of dysplastic naevi: results of a multiregional UK questionnaire study Get access Fazleenah A Hussain, Fazleenah A Hussain Department of Dermatology, Wrexham Maelor Hospital, Wrexham, UK Correspondence: Fazleenah. A. Hussain Email:fazleenah.ajmulhussain@wales.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar Arti Bakshi, Arti Bakshi Department of Cellular Pathology, Liverpool Clinical Laboratories, Liverpool University Hospitals Foundation Trust, Liverpool, UK Search for other works by this author on: Oxford Academic Google Scholar Paul D Yesudian, Paul D Yesudian Department of Dermatology, Wrexham Maelor Hospital, Wrexham, UK Search for other works by this author on: Oxford Academic Google Scholar Stuart N Cohen Stuart N Cohen Department of Dermatology, Liverpool University Hospitals NHS Foundation Trust and School of Medicine, University of Liverpool, Liverpool, UK Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, ljae382, https://doi.org/10.1093/bjd/ljae382 Published: 18 October 2024 Article history Received: 15 July 2024 Revision received: 13 September 2024 Accepted: 07 October 2024 Published: 18 October 2024
Orthodontic management of uneven gingival margins in patients with healthy or reduced periodontium to improve smile aesthetics
Authors: Conchita Martin, Spyridon N. Papageorgiou, Oscar Gonzalez‐Martin, Mariano Sanz
Journal: Periodontology 2000 (2024)

Abstract Uneven gingival margins may cause visible asymmetries during smiling and may reflect alterations in the tooth shape and morphology, particularly in cases requiring restorative procedures. Despite being perceived as a minor health condition, presence of uneven gingival margins usually impacts the smile aesthetics and could affect the individual's appearance, self‐esteem, and overall quality of life, especially in subjects with a high smile line. Uneven gingival margins may result from different causes, which makes an accurate diagnosis fundamental for its treatment planning. Orthodontic treatment often serves as a conservative approach for leveling these margins, by achieving the most appropriate tooth position. This article reviews the rationale, differential diagnosis, and clinical management of uneven gingival margins using orthodontic tooth movements, providing insights for orthodontists, periodontists, and restorative dentists on the interdisciplinary care needed to correct this condition, and hence, to improve the subject's smile aesthetics.
Mycoplasma pneumoniae incidence, phenotype, and severity in children and adolescents in Denmark before, during, and after the COVID-19 pandemic: a nationwide multicentre population-based cohort study
Authors: Kia H S Dungu, Mette Holm, Ulla Hartling, Lise H Jensen, Allan Bybeck Nielsen, Lisbeth S Schmidt, Lise B Toustrup, Lotte H Hansen, Kathrin W Dahl, Kirstine T Matthesen, Anne C Nordholm, Søren Uldum, Hanne-Dorthe Emborg, Maren J H Rytter, Ulrikka Nygaard
Journal: The Lancet Regional Health - Europe (2024)
Efficacy and safety of a novel low-dose triple single-pill combination of telmisartan, amlodipine and indapamide, compared with dual combinations for treatment of hypertension: a randomised, double-blind, active-controlled, international clinical trial
Authors: Anthony Rodgers, Abdul Salam, Aletta E Schutte, William C Cushman, H Asita de Silva, Gian Luca Di Tanna, Diederick E Grobbee, Krzysztof Narkiewicz, Dike B Ojji, Neil R Poulter, Markus P Schlaich, Suzanne Oparil, Wilko Spiering, Bryan Williams, Jackson T Wright, P Lakshman, W Uluwattage, P Hay, T Pereira, N Amarasena, G Ranasinghe, Chris Gianacas, Mathangi Shanthakumar, Xiaoqiu Liu, Nelson Wang, Sonali R Gnanenthiran, Paul K Whelton
Journal: The Lancet (2024)
Respiratory syncytial virus (RSV) vaccine effectiveness against RSV-associated hospitalisations and emergency department encounters among adults aged 60 years and older in the USA, October, 2023, to March, 2024: a test-negative design analysis
Authors: Amanda B Payne, Janet A Watts, Patrick K Mitchell, Kristin Dascomb, Stephanie A Irving, Nicola P Klein, Shaun J Grannis, Toan C Ong, Sarah W Ball, Malini B DeSilva, Karthik Natarajan, Tamara Sheffield, Daniel Bride, Julie Arndorfer, Allison L Naleway, Padma Koppolu, Bruce Fireman, Ousseny Zerbo, Julius Timbol, Kristin Goddard, Brian E Dixon, William F Fadel, Colin Rogerson, Katie S Allen, Suchitra Rao, David Mayer, Michelle Barron, Sarah E Reese, Elizabeth A K Rowley, Morgan Najdowski, Allison Avrich Ciesla, Josephine Mak, Emily L Reeves, Omobosola O Akinsete, Charlene E McEvoy, Inih J Essien, Mark W Tenforde, Katherine E Fleming-Dutra, Ruth Link-Gelles
Journal: The Lancet (2024)
Effect of a participatory whole-systems approach on mortality in children younger than 5 years in Jigawa state, Nigeria (INSPIRING trial): a community-based, parallel-arm, pragmatic, cluster randomised controlled trial and concurrent mixed-methods process evaluation
Authors: Carina King, Rochelle Ann Burgess, Ayobami A Bakare, Funmilayo Shittu, Julius Salako, Damola Bakare, Obioma C Uchendu, Agnese Iuliano, Nehla Djellouli, Adamu Isah, Ibrahim Haruna, Samy Ahmar, Tahlil Ahmed, Paula Valentine, Temitayo Folorunso Olowookere, Matthew MacCalla, Hamish R Graham, Eric D McCollum, James Beard, Adegoke G Falade, Tim Colbourn
Journal: The Lancet Global Health (2024)
Global action on problematic usage of the internet: announcing a Lancet Psychiatry Commission
Authors: Naomi A Fineberg, Zsolt Demetrovics, Marc N Potenza, Gemma Mestre-Bach, Hamed Ekhtiari, Andres Roman-Urrestarazu, Sophia Achab, Thomas Kattau, Henrietta Bowden-Jones, Shane A Thomas, Thomas F Babor, Beeban Kidron, Dan J Stein
Journal: The Lancet Psychiatry (2024)
Climate emotions, thoughts, and plans among US adolescents and young adults: a cross-sectional descriptive survey and analysis by political party identification and self-reported exposure to severe weather events
Authors: R Eric Lewandowski, Susan D Clayton, Lukas Olbrich, Joseph W Sakshaug, Britt Wray, Sarah E O Schwartz, Jura Augustinavicius, Peter D Howe, McKenna Parnes, Sacha Wright, Caitlyn Carpenter, Arkadiusz Wiśniowski, Diego Perez Ruiz, Lise Van Susteren
Journal: The Lancet Planetary Health (2024)
Outcomes After Brexucabtagene Autoleucel Administered as a Standard Therapy for Adults With Relapsed/Refractory B-Cell ALL
Authors: Gregory W. Roloff, Ibrahim Aldoss, Noam E. Kopmar, Chenyu Lin, Simone E. Dekker, Vishal K. Gupta, Timothy E. O'Connor, Nikeshan Jeyakumar, Ibrahim N. Muhsen, Yannis Valtis, Naveed Ahmed, Amy Zhang, Katharine Miller, Kaitlyn C. Dykes, Mohamed Ahmed, Evan C. Chen, Santiago Mercadal, Marc Schwartz, Sean I. Tracy, Bhagirathbhai Dholaria, Akash Mukherjee, Minoo Battiwalla, Aaron C. Logan, Abdullah Ladha, Caitlin Guzowski, Rasmus T. Hoeg, Talal Hilal, Jozal Moore, Matthew P. Connor, LaQuisa C. Hill, Stephanie B. Tsai, Joshua P. Sasine, Melhem M. Solh, Vamsi K. Kota, Divya Koura, Muthu Veeraputhiran, Jessica T. Leonard, Noelle V. Frey, Jae H. Park, Marlise R. Luskin, Veronika Bachanova, Ahmed Galal, Vinod Pullarkat, Wendy Stock, Ryan D. Cassaday, Bijal D. Shah, Rawan Faramand, Lori Muffly, Caspian Oliai, George Yaghmour, Katherine Sutherland, Hector Zambrano, Danielle Bradshaw, Michal Kubiak, Navneet Majhail, Luke Mountjoy, Shahbaz A. Malik, John Mathews, Paul Shaughnessy, Anjali S. Advani, Maryann Stefan, Kristen M. O'Dwyer, Catherine J. Lee, Betsy Blunk, Michael R. Bishop
Journal: Journal of Clinical Oncology (2024)

On the basis of the results of the ZUMA-3 trial, brexucabtagene autoleucel (brexu-cel), a CD19-directed chimeric antigen receptor T-cell therapy, gained US Food and Drug Administration approval in October 2021 for adults with relapsed/refractory (R/R) B-cell ALL (B-ALL). We report outcomes of patients treated with brexu-cel as a standard therapy.
EFFECT of daily antiseptic bathing with octenidine on ICU-acquired bacteremia and ICU-acquired multidrug-resistant organisms: a multicenter, cluster-randomized, double-blind, placebo-controlled, cross-over study
Authors: Tiffany Schaumburg, Norbert Köhler, Yasmine Breitenstein, Susanne Kolbe-Busch, Dirk Hasenclever, Iris F. Chaberny
Journal: Intensive Care Medicine (2024)

Antiseptic bathing has garnered attention in an effort to reduce hospital-acquired infections. Previous studies have shown the efficacy of antiseptic bathing in high-risk environments, such as intensive care units (ICUs), using chlorhexidine. In this study we aimed to evaluate the effectiveness of octenidine as a potential alternative due to its established popularity and widespread use in Europe.
MHConstructor: a high-throughput, haplotype-informed solution to the MHC assembly challenge
Authors: Kristen J. Wade, Rayo Suseno, Kerry Kizer, Jacqueline Williams, Juliano Boquett, Stacy Caillier, Nicholas R. Pollock, Adam Renschen, Adam Santaniello, Jorge R. Oksenberg, Paul J. Norman, Danillo G. Augusto, Jill A. Hollenbach
Journal: Genome biology (2024)

The extremely high levels of genetic polymorphism within the human major histocompatibility complex (MHC) limit the usefulness of reference-based alignment methods for sequence assembly. We incorporate a short-read, de novo assembly algorithm into a workflow for novel application to the MHC. MHConstructor is a containerized pipeline designed for high-throughput, haplotype-informed, reproducible assembly of both whole genome sequencing and target capture short-read data in large, population cohorts. To-date, no other self-contained tool exists for the generation of de novo MHC assemblies from short-read data. MHConstructor facilitates wide-spread access to high-quality, alignment-free MHC sequence analysis.
Eighteen-Month Hybrid Closed-Loop Use in Very Young Children With Type 1 Diabetes: A Single-Arm Multicenter Trial
Authors: Julia Ware, Janet M. Allen, Charlotte K. Boughton, Malgorzata E. Wilinska, Sara Hartnell, Ajay Thankamony, Carine de Beaufort, Fiona M. Campbell, Elke Fröhlich-Reiterer, Maria Fritsch, Sabine E. Hofer, Thomas M. Kapellen, Birgit Rami-Merhar, Martin Tauschmann, Roman Hovorka, Roman Hovorka, Carlo L Acerini, Ajay Thankamony, Charlotte K Boughton, Klemen Dovc, Julia Ware, Gianluca Musolino, Malgorzata E Wilinska, Janet M Allen, Sara Hartnell, Yue Ruan, Nicole Ashcroft, Matthew Haydock, Catherine Hill, Maria Fritsch, Hildegard Jasser-Nitsche, Julia K Mader, Kerstin Faninger, Thomas M Kapellen, Heike Bartelt, Alena Thiele, Birgit Rami-Merhar, Gabriele Berger, Nicole Blauensteiner, Renata Gellai, Katrin Nagl, Martin Tauschmann, Sarah Cvach, Sonja Katzenbeisser-Pawlik, Sabine E Hofer, Daniela Abt, Anita Malik, Barbara Lanthaler, Matthias Wenzel, Fiona Campbell, James Yong, Emily Metcalfe, Majorie Allen, Sarah Ambler, Saima Waheed, Jane Exall, Joseph Tulip, Carine de Beaufort, Ulrike Schierloh, Muriel Fichelle, Dominique Schaeffer, Julia Lawton, David Rankin, Ruth Hart, Barbara Kimbell, Stéphane Roze, Timothy Jones, Chris Patterson, Peter Adolfsson
Journal: Diabetes Care (2024)

We aimed to evaluate the longer-term safety and efficacy of hybrid closed-loop (CL) therapy in very young children with type 1 diabetes (T1D).
Effect of oral health on functional disability and mortality in older adults in Japan: a cohort study
Authors: Takafumi Abe, Kazumichi Tominaga, Hisaaki Saito, Jun Shimizu, Norikuni Maeda, Ryouji Matsuura, Yukio Inoue, Yuichi Ando, Yuhei Matsuda, Takahiro Kanno, Shozo Yano, Minoru Isomura
Journal: The Lancet Healthy Longevity (2024)
P18.25.B IMPACT OF ONLINE EDUCATION ON CLINICIANS’ KNOWLEDGE AND CONFIDENCE IN THE UNDERSTANDING OF EMERGING TARGETED THERAPIES FOR IDH-MUTANT GLIOMAS
Authors: Z Fiske, D Grainger, J Habib, M Touat, M Preusser, P Y Wen
Journal: Neuro-Oncology (2024)

Abstract BACKGROUND The discovery of the IDH mutations represents a hallmark in the field of neuro-oncology, leading to significant progress in terms of glioma classification and potential novel therapeutic approaches for these tumors. The objective of this study was to assess the effect of an online continuing medical education (CME) activity on clinicians’ understanding of the clinical implications of recent research advances and how emerging systemic therapies could benefit patients with IDH-mutant glioma. MATERIAL AND METHODS This CME activity consisted of a 90-minute video recording of a live symposium at the Society for Neuro-Oncology Annual Conference in 2023, together with synchronised slides. Educational effect was assessed using a repeated-pair design with pre-/post-assessment. 3 multiple choice questions assessed knowledge/competence, and 1 question rated on a Likert-type scale assessed confidence, with each individual serving as their own control. A McNemar’s test assessed significance of improvement in the percentage of correct responses to knowledge/competence questions from pre- to post-assessment. P values &amp;lt;.05 are statistically significant. The activity launched on 15th of December 2023, with data collected through 26th February 2024 being reported in the current study. RESULTS 86 neurosurgeons and 47 oncologists who answered all the assessment questions were included in this analysis. Both physician groups demonstrated a statistically significant improvement in knowledge across all learning themes. Overall correct responses increased from 17% pre- to 27% post-CME for neurosurgeons, and 33% pre- to 50% post-CME for oncologists, respectively. Specific areas of improvement include: knowledge regarding the latest clinical trial data of targeted therapies for IDH-mutant gliomas (pre 17%, post 28%, P &amp;lt;.001 for neurosurgeons; pre 27%, post 47%, P &amp;lt;.001 for oncologists); knowledge regarding identifying patients with IDH-mutant glioma who may benefit from emerging targeted therapies (pre 16%, post 24%, P &amp;lt;.01 for neurosurgeons; pre 47%, post 55%, P &amp;lt;.05 for oncologists). Additionally, 28% of neurosurgeons and 34% of oncologists reported increased confidence in their understanding of the potential clinical practice implications of emerging targeted therapies for IDH-mutant glioma, and that increase was, on average, 75% and 67% among the two physician groups, respectively. CONCLUSION This analysis demonstrates a positive educational impact of an online CME activity on the latest developments in the management of IDH-mutant glioma for key physician learner groups. It also highlights the ongoing educational needs to further improve clinician’s knowledge and help them stay up to date with the latest developments in the field.