tbuckley/cabot-search huggingface dataset:
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
Authors: Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh
Journal: Medicinal Research Reviews (2024)

Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral infections. They can promote or inhibit viral infection and have a pro‐viral or antiviral role. Also, viral infections can modulate the expression of host miRNAs. Furthermore, viruses from different families evade the host immune response by producing their own miRNAs called viral miRNAs (v‐miRNAs). Understanding the replication cycle of viruses and their relation with host miRNAs and v‐miRNAs can help to find new treatments against viral infections. In this review, we aim to outline the structure, genome, and replication cycle of various viruses including hepatitis B, hepatitis C, influenza A virus, coronavirus, human immunodeficiency virus, human papillomavirus, herpes simplex virus, Epstein–Barr virus, Dengue virus, Zika virus, and Ebola virus. We also discuss the role of different host miRNAs and v‐miRNAs and their role in the pathogenesis of these viral infections.
Gradient Conducting Polymer Surfaces with Netrin-1-conjugation Promote Axon Guidance and Neuron Transmission of Human iPSC-derived Retinal Ganglion Cells
Authors: Jia-Wei She, Chia-Mei Young, Shih-Jie Chou, You-Ren Wu, Yu-Ting Lin, Tzu-Yang Huang, Mo-Yuan Shen, Chih-Ying Chen, Yi-Ping Yang, Yueh Chien, Hailemichael Ayalew, Wei-Hao Liao, Yi-Chung Tung, Jing-Jong Shyue, Shih-Hwa Chiou, Hsiao-Hua Yu
Journal: Biomaterials (2024)
A reliable clinical test for detection of membranous nephropathy antigens using laser microdissection and mass spectrometry
Authors: Julie A Vrana, Jason D Theis, Peter J Wegwerth, Surendra Dasari, Benjamin Madden, Samih H Nasr, Mary Fidler, Ellen D McPhail, Fernando C Fervenza, Sanjeev Sethi
Journal: Kidney International (2024)
Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling
Authors: Takahiro Nakajima, Toshio Kanno, Yuki Ueda, Keisuke Miyako, Takeru Endo, Souta Yoshida, Satoru Yokoyama, Hikari K. Asou, Kazuko Yamada, Kazutaka Ikeda, Yosuke Togashi, Yusuke Endo
Journal: Cellular and Molecular Immunology (2024)

T helper 9 (Th9) cells are interleukin 9 (IL-9)-producing cells that have diverse functions ranging from antitumor immune responses to allergic inflammation. Th9 cells differentiate from naïve CD4
Endoplasmic reticulum stress in diseases
Authors: Yingying Liu, Chunling Xu, Renjun Gu, Ruiqin Han, Ziyun Li, Xianrong Xu
Journal: MedComm (2024)

The endoplasmic reticulum (ER) is a key organelle in eukaryotic cells, responsible for a wide range of vital functions, including the modification, folding, and trafficking of proteins, as well as the biosynthesis of lipids and the maintenance of intracellular calcium homeostasis. A variety of factors can disrupt the function of the ER, leading to the aggregation of unfolded and misfolded proteins within its confines and the induction of ER stress. A conserved cascade of signaling events known as the unfolded protein response (UPR) has evolved to relieve the burden within the ER and restore ER homeostasis. However, these processes can culminate in cell death while ER stress is sustained over an extended period and at elevated levels. This review summarizes the potential role of ER stress and the UPR in determining cell fate and function in various diseases, including cardiovascular diseases, neurodegenerative diseases, metabolic diseases, autoimmune diseases, fibrotic diseases, viral infections, and cancer. It also puts forward that the manipulation of this intricate signaling pathway may represent a novel target for drug discovery and innovative therapeutic strategies in the context of human diseases.
The genetic architecture of recombination rates is polygenic and differs between the sexes in wild house sparrows (<i>Passer domesticus</i>)
Authors: John B McAuley, Bertrand Servin, Hamish A Burnett, Cathrine Brekke, Lucy Peters, Ingerid J Hagen, Alina K Niskanen, Thor Harald Ringsby, Arild Husby, Henrik Jensen, Susan E Johnston
Journal: Molecular Biology and Evolution (2024)

Abstract Meiotic recombination through chromosomal crossing-over is a fundamental feature of sex and an important driver of genomic diversity. It ensures proper disjunction, allows increased selection responses, and prevents mutation accumulation; however, it is also mutagenic and can break up favorable haplotypes. This cost–benefit dynamic is likely to vary depending on mechanistic and evolutionary contexts, and indeed, recombination rates show huge variation in nature. Identifying the genetic architecture of this variation is key to understanding its causes and consequences. Here, we investigate individual recombination rate variation in wild house sparrows (Passer domesticus). We integrate genomic and pedigree data to identify autosomal crossover counts (ACCs) and intrachromosomal allelic shuffling (r¯intra) in 13,056 gametes transmitted from 2,653 individuals to their offspring. Females had 1.37 times higher ACC, and 1.55 times higher r¯intra than males. ACC and r¯intra were heritable in females and males (ACC h2 = 0.23 and 0.11; r¯intra h2 = 0.12 and 0.14), but cross-sex additive genetic correlations were low (rA = 0.29 and 0.32 for ACC and r¯intra). Conditional bivariate analyses showed that all measures remained heritable after accounting for genetic values in the opposite sex, indicating that sex-specific ACC and r¯intra can evolve somewhat independently. Genome-wide models showed that ACC and r¯intra are polygenic and driven by many small-effect loci, many of which are likely to act in trans as global recombination modifiers. Our findings show that recombination rates of females and males can have different evolutionary potential in wild birds, providing a compelling mechanism for the evolution of sexual dimorphism in recombination.
Clinically mild hidradenitis suppurativa: mild for whom?
Authors: Tonia Samela, Giulia Raimondi, Giusi Pintori, Maria Beatrice Pupa, Giorgia Cordella, Valeria Antinone, Nidia Melo Salcedo, Roberta Fusari, Sabatino Pallotta, Francesca Sampogna, Luca Fania, Davide Ciccone, Giovanni Pellacani, Damiano Abeni
Journal: British Journal of Dermatology (2024)

Severe levels of illness, measured through patient-reported outcomes, are frequent among patients with hidradenitis suppurativa classified as having mild disease according to the International Hidradenitis Suppurativa Score System. The systematic use in clinical practice of patient-centred outcome measures, capable of accurately detecting and portraying the true severity of the impact of skin conditions, may help improve patient care.
Seqrutinator: scrutiny of large protein superfamily sequence datasets for the identification and elimination of non-functional homologues
Authors: Agustín Amalfitano, Nicolás Stocchi, Hugo Marcelo Atencio, Fernando Villarreal, Arjen ten Have
Journal: Genome biology (2024)

Seqrutinator is an objective, flexible pipeline that removes sequences with sequencing and/or gene model errors and sequences from pseudogenes from complex, eukaryotic protein superfamilies. Testing Seqrutinator on major superfamilies BAHD, CYP, and UGT removes only 1.94% of SwissProt entries, 14% of entries from the model plant Arabidopsis thaliana, but 80% of entries from Pinus taeda's recent complete proteome. Application of Seqrutinator on crude BAHDomes, CYPomes, and UGTomes obtained from 16 plant proteomes shows convergence of the numbers of paralogues. MSAs, phylogenies, and particularly functional clustering improve drastically upon Seqrutinator application, indicating good performance.
A united call for gender equity in global health leadership
Authors: Catherine Moughalian, Malvikha Manoj, Aysha Farwin, Bettina Buabeng-Baidoo, Bisrat Dessalegn, Deena Mariyam, Deepika Saluja, Flata Mwale, Flávia Virginio, Joy Muhia, Jumana Hashim, Lakshmi Menon, Laura Haywood, Lauren Tejkl, Laurenice de Jesus Alves Pires, Marali Singaraju, Merette Khalil, Rita Rasoa Sakari, Sabreen AbeedAllah, Salome Maswime, Somto Chloe Keluo-Udeke, Taofeekat Adigun, Roopa Dhatt
Journal: Nature Medicine (2024)
A 27-country test of communicating the scientific consensus on climate change
Authors: Bojana Većkalov, Sandra J. Geiger, František Bartoš, Mathew P. White, Bastiaan T. Rutjens, Frenk van Harreveld, Federica Stablum, Berkan Akın, Alaa Aldoh, Jinhao Bai, Frida Berglund, Aleša Bratina Zimic, Margaret Broyles, Andrea Catania, Airu Chen, Magdalena Chorzępa, Eman Farahat, Jakob Götz, Bat Hoter-Ishay, Gesine Jordan, Siri Joustra, Jonas Klingebiel, Živa Krajnc, Antonia Krug, Thomas Lind Andersen, Johanna Löloff, Divya Natarajan, Sasha Newman-Oktan, Elena Niehoff, Celeste Paerels, Rachel Papirmeister, Steven Peregrina, Felicia Pohl, Amanda Remsö, Abigail Roh, Binahayati Rusyidi, Justus Schmidt, Mariam Shavgulidze, Valentina Vellinho Nardin, Ruixiang Wang, Kelly Warner, Miranda Wattier, Chloe Y. Wong, Mariem Younssi, Kai Ruggeri, Sander van der Linden
Journal: Nature Human Behaviour (2024)

Abstract Communicating the scientific consensus that human-caused climate change is real increases climate change beliefs, worry and support for public action in the United States. In this preregistered experiment, we tested two scientific consensus messages, a classic message on the reality of human-caused climate change and an updated message additionally emphasizing scientific agreement that climate change is a crisis. Across online convenience samples from 27 countries ( n = 10,527), the classic message substantially reduces misperceptions ( d = 0.47, 95% CI (0.41, 0.52)) and slightly increases climate change beliefs (from d = 0.06, 95% CI (0.01, 0.11) to d = 0.10, 95% CI (0.04, 0.15)) and worry ( d = 0.05, 95% CI (−0.01, 0.10)) but not support for public action directly. The updated message is equally effective but provides no added value. Both messages are more effective for audiences with lower message familiarity and higher misperceptions, including those with lower trust in climate scientists and right-leaning ideologies. Overall, scientific consensus messaging is an effective, non-polarizing tool for changing misperceptions, beliefs and worry across different audiences.
Robust genome and cell engineering via in vitro and in situ circularized RNAs
Authors: Michael Tong, Nathan Palmer, Amir Dailamy, Aditya Kumar, Hammza Khaliq, Sangwoo Han, Emma Finburgh, Madeleine Wing, Camilla Hong, Yichen Xiang, Katelyn Miyasaki, Andrew Portell, Joseph Rainaldi, Amanda Suhardjo, Sami Nourreddine, Wei Leong Chew, Ester J. Kwon, Prashant Mali
Journal: Nature Biomedical Engineering (2024)
Clinical response and pathway-specific correlates following TIGIT–LAG3 blockade in myeloma: the MyCheckpoint randomized clinical trial
Authors: Shambavi Richard, Alexander M. Lesokhin, Barry Paul, Jonathan L. Kaufman, Matthew Pianko, Noa Biran, Ravi Vij, Deon B. Doxie, Maryam I. Azeem, Mercedes Martillo, Katie Wozniak, Hearn J. Cho, Kavita M. Dhodapkar, Madhav V. Dhodapkar
Journal: Nature Cancer (2024)
Proteomic changes in Alzheimer disease associated with progressive Aβ plaque and tau tangle pathologies
Authors: Alexa Pichet Binette, Chris Gaiteri, Malin Wennström, Atul Kumar, Ines Hristovska, Nicola Spotorno, Gemma Salvadó, Olof Strandberg, Hansruedi Mathys, Li-Huei Tsai, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Shorena Janelidze, Erik Stomrud, Jacob W. Vogel, Oskar Hansson
Journal: Nature Neuroscience (2024)

Abstract Proteomics can shed light on the dynamic and multifaceted alterations in neurodegenerative disorders like Alzheimer’s disease (AD). Combining radioligands measuring β-amyloid (Aβ) plaques and tau tangles with cerebrospinal fluid proteomics, we uncover molecular events mirroring different stages of AD pathology in living humans. We found 127 differentially abundant proteins (DAPs) across the AD spectrum. The strongest Aβ-related proteins were mainly expressed in glial cells and included SMOC1 and ITGAM. A dozen proteins linked to ATP metabolism and preferentially expressed in neurons were independently associated with tau tangle load and tau accumulation. Only 20% of the DAPs were also altered in other neurodegenerative diseases, underscoring AD’s distinct proteome. Two co-expression modules related, respectively, to protein metabolism and microglial immune response encompassed most DAPs, with opposing, staggered trajectories along the AD continuum. We unveil protein signatures associated with Aβ and tau proteinopathy in vivo, offering insights into complex neural responses and potential biomarkers and therapeutics targeting different disease stages.
Microbiota and glioma: a new perspective from association to clinical translation
Authors: Wenhui Wang, Zihao Ou, Xixin Huang, Jingyu Wang, Qianbei Li, Minghui Wen, Lei Zheng
Journal: Gut Microbes (2024)

Gliomas pose a significant challenge in oncology due to their malignant nature, aggressive growth, frequent recurrence, and complications posed by the blood-brain barrier. Emerging research has revealed the critical role of gut microbiota in influencing health and disease, indicating its possible impact on glioma pathogenesis and treatment responsiveness. This review focused on existing evidence and hypotheses on the relationship between microbiota and glioma from progression to invasion. By discussing possible mechanisms through which microbiota may affect glioma biology, this paper offers new avenues for targeted therapies and precision medicine in oncology.
Genetic associations between non-cognitive skills and academic achievement over development
Authors: Margherita Malanchini, Andrea G. Allegrini, Michel G. Nivard, Pietro Biroli, Kaili Rimfeld, Rosa Cheesman, Sophie von Stumm, Perline A. Demange, Elsje van Bergen, Andrew D. Grotzinger, Laurel Raffington, Javier De la Fuente, Jean-Baptiste Pingault, Elliot M. Tucker-Drob, K. Paige Harden, Robert Plomin
Journal: Nature Human Behaviour (2024)

Abstract Non-cognitive skills, such as motivation and self-regulation, are partly heritable and predict academic achievement beyond cognitive skills. However, how the relationship between non-cognitive skills and academic achievement changes over development is unclear. The current study examined how cognitive and non-cognitive skills are associated with academic achievement from ages 7 to 16 years in a sample of over 10,000 children from England and Wales. The results showed that the association between non-cognitive skills and academic achievement increased across development. Twin and polygenic scores analyses found that the links between non-cognitive genetics and academic achievement became stronger over the school years. The results from within-family analyses indicated that non-cognitive genetic effects on academic achievement could not simply be attributed to confounding by environmental differences between nuclear families, consistent with a possible role for evocative/active gene–environment correlations. By studying genetic associations through a developmental lens, we provide further insights into the role of non-cognitive skills in academic development.
Endoscopic Ultrasound-Guided Rendezvous Technique Versus Precut Sphincterotomy as Salvage Technique in Patients With Benign Biliary Disease and Difficult Biliary Cannulation
Authors: Arup Choudhury, Jayanta Samanta, Gaurav Muktesh, Jahnvi Dhar, Antriksh Kumar, Jimil Shah, Marco Spadaccini, Pankaj Gupta, Alessandro Fugazza, Vikas Gupta, Thakur Deen Yadav, Rakesh Kochhar, Cesare Hassan, Alessandro Repici, Antonio Facciorusso
Journal: Annals of Internal Medicine (2024)

The standard salvage technique used for difficult bile duct cannulation is precut sphincterotomy, whereas endoscopic ultrasound-guided rendezvous technique (EUS-RV) is a relatively newer method. Prospective comparative data between these 2 techniques as salvage for biliary access in patients with benign biliary disease and difficult bile duct cannulation is lacking.
A combination therapy with secukinumab and dupilumab in Netherton syndrome: A prospective pilot study
Authors: Taoming Liu, Manman Tang, Jiao Liu, Tinghui Kong, Yuyang Tian, Sai Yang, Jiao Zhang, Suyun Ji, Zhimiao Lin, Ruzeng Xue, Yan Ding, Bin Yang, Yunsheng Liang
Journal: Journal of the American Academy of Dermatology (2024)
Effective and durable repigmentation for stable vitiligo: a randomized within-subject controlled trial assessing treatment with autologous skin cell suspension transplantation
Authors: Iltefat H Hamzavi, Anand K Ganesan, Bassel H Mahmoud, Eduardo Weiss, Ammar M Ahmed, Deanne Robinson, Mitchel P Goldman, Girish Munavalli, Steven A Kahn, Victor Huang, Jill Waibel, Alpesh Desai, Nada Elbuluk, Seemal Desai, Amit G Pandya
Journal: Journal of the American Academy of Dermatology (2024)

Vitiligo lesions are often challenging to repigment with conventional medical therapies. Surgical autologous melanocyte transfer methods can be utilized for stable vitiligo but demand specialized skills and equipment. A point-of-care autologous cell harvesting device was designed enabling simple preparation of autologous skin cell suspension (ASCS) containing melanocytes, keratinocytes, and fibroblasts providing a straightforward approach for cellular transplantation.
A study of ultra-low dose rituximab as adjuvant to standard of care in treatment of significant and extensive pemphigus vulgaris: a case series
Authors: Nayankumar H Patel, Jignaben K Padhiyar, Jahnvi R Patel, Kathak A Patel, Megha P Lakum, Yaksh Pradeep Oza, Harisiddhi Bharatbhai Patel, Prashant Bhikhabhai Chaudhary
Journal: Journal of the American Academy of Dermatology (2024)
Which trial do we need? Combination therapy with daptomycin plus ceftaroline versus standard of care monotherapy in the treatment of Methicillin-resistant Staphylococcus aureus bacteremia
Authors: Myeongji Kim, Nischal Ranganath, Supavit Chesdachai, Ryan W Stevens, Muhammad Rizwan Sohail, Omar M Abu Saleh
Journal: Clinical Microbiology and Infection (2024)
An oil-in-gel type of organohydrogel loaded with methylprednisolone for the treatment of secondary injuries following spinal cord traumas
Authors: Yinqiu Tan, Ting Lai, Yuntao Li, Qi Tang, Weijia Zhang, Qi Liu, Sihan Wu, Xiao Peng, Xiaofeng Sui, Fulvio Reggiori, Xiaobing Jiang, Qianxue Chen, Cuifeng Wang
Journal: Journal of Controlled Release (2024)
Harnessing transcription factor-driven ROS for synergistic multimodal lung cancer treatment
Authors: Ye Zhou, Simeng Wang, Jiahua Guo, Chenghao Li, Mengjun Sui, Zekun Zeng, Hui Dang, Qingqing Gu, Jian Zhu, Yangyang Cheng, Peng Hou
Journal: Journal of Controlled Release (2024)

Multimodal treatment of cancer is an unstoppable revolution in clinical application. However, designing a platform that integrates therapeutic modalities with different pharmacokinetic characteristics remains a great challenge. Herein, we designed a universal lipid nanoplatform equipping a ROS-cleavable docetaxel prodrug (DTX-L-DTX) and an NF-E2-related factor 2 (NRF2) inhibitor (clobetasol propionate, CP). This simply fabricated nanomedicine enables superior synergistic molecularly targeted/chemo/radio therapy for lung cancer cascade by a transcription factor-driven ROS self-sustainable motion. Chemotherapy is launched via ROS-triggered DTX release. Subsequently, CP inhibits the expression of NRF2 target genes, resulting in efficient targeted therapy, meanwhile inducing sustained ROS generation which in turn facilitates chemotherapy by overcoming ROS consumption during the DTX release process. Finally, the introduction of radiotherapy further amplifies ROS, offering continuous mutual feedback to amplify the ultimate treatment performance. This strategy is conceptually and operationally simple, providing solutions to challenges in clinical cancer treatment and beyond.
The IL-6 hypothesis in COVID-19: A phase 2, randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of free IL-6 sequestration by the monoclonal antibody sirukumab in severe and critical COVID-19
Authors: Robert L. Gottlieb, Meredith Clement, Paul Cook, Audra Deveikis, Kap Sum Foong, Philip Robinson, Jihad Slim, Cedric W. Spak, Annemie Buelens, Katleen Callewaert, Sandra De Meyer, Wai Ling Mo, Inge Verbrugge, Liesbeth Van Wesenbeeck, Yanli Zhuang, Jason W. Chien, Magda Opsomer, Erika Van Landuyt
Journal: Journal of Infection (2024)

Upregulation of IL-6 has been associated with worse prognosis in COVID-19 patients. Impact on IL-6 signalling has mostly been limited to clinical outcomes in IL-6 receptor antagonist trials.
Dermatoscopic predictors of histopathologically aggressive basal cell carcinoma and their positive impact of subtype prediction by human readers
Authors: Elisa Camela, Paula Ilut Anca, Athanassios Kyrgidis, Konstantinos Lallas, Massimiliano Scalvenzi, Chryssoula Papageorgiou, Sofia-Magdalini Manoli, Theodosia Gkentsidi, Polychronia Eftychidou, Florentina Silvia Delli, Vlassios Eleftheriadis, Stella Sakellaropoulou, Ilias Papadimitriou, Iulia Maria Badiu, Ana Cutoiu, Katarzyna Korecka, Efstratios Vakirlis, Elena Sotiriou, Zoe Apalla, Aimilios Lallas
Journal: Journal of the American Academy of Dermatology (2024)
MERLIN: Two-Year Results of Brolucizumab in Participants With Neovascular Age-Related Macular Degeneration and Persistent Retinal Fluid
Authors: David M Brown, Glenn J Jaffe, Charles C Wykoff, Eser Adiguzel, Jeffrey S Heier, Arshad M Khanani
Journal: Ophthalmology (2024)

To report the safety and efficacy of brolucizumab (Beovu®) 6 mg vs. aflibercept (Eylea®) 2 mg administered every 4 weeks in participants with neovascular age-related macular degeneration (nAMD) and persistent retinal fluid after the Week 52 primary endpoint analysis (from Week 52 up to Week 104, post-study termination).
Dexamethasone in adults with viral meningitis: an observational cohort study
Authors: Pelle Trier Petersen, Jacob Bodilsen, Micha Phill Grønholm Jepsen, Lykke Larsen, Merete Storgaard, Birgitte Rønde Hansen, Jannik Helweg-Larsen, Lothar Wiese, Hans Rudolf Lüttichau, Christian Østergaard Andersen, Henrik Nielsen, Christian Thomas Brandt
Journal: Clinical Microbiology and Infection (2024)

To investigate whether there is a dose-dependent association between empiric dexamethasone and outcome in viral meningitis.
The role of ultraviolet induced fluorescence dermoscopy for the detection of multiple aggregated yellow-white (MAY) globules in basal cell carcinoma.
Authors: Cristian Navarrete-Dechent, Pawel Pietkiewicz, Gisel Astronave, Nadeem G Marghoob, Stephen W Dusza, Josefina Lorenzoni, Manuela Boleira, Michael Cristopher, Rosario Aguero, Sergio Bustos, Natalia Jaimes, Maria Kurpis, Leonel Hidalgo, Alvaro Abarzua-Araya, Pablo Zoroquiain, Pablo Uribe, Consuelo Cárdenas, Katherine Droppelmann, Ashfaq A Marghoob
Journal: Journal of the American Academy of Dermatology (2024)
Comparative Efficacy of Biologics and Small Molecule in Ulcerative Colitis: A Systematic Review and Network Meta-analysis
Authors: Mohammad Shehab, Fatema Alrashed, Abdulwahab Alsayegh, Usama Aldallal, Christopher Ma, Neeraj Narula, Vipul Jairath, Siddharth Singh, Talat Bessissow
Journal: Clinical Gastroenterology and Hepatology (2024)
A Retrospective Clinical and Laboratory Analysis including Vitamin D and Antinuclear Antibodies in Central Centrifugal Cicatricial Alopecia and Non-Scarring Alopecia in African Americans
Authors: Pearl E Grimes, Shanaya Dias, Angela Kyei, Tatiana V Tatarinova, Andrew Alexis, Nada Elbuluk, Lynn Drake, Jerry Shapiro
Journal: Journal of the American Academy of Dermatology (2024)