tbuckley/cabot-search huggingface dataset:
Glioma invadomics - identification and validation of novel targets for glioma invasion in-vivo
Authors: Linsey B. Reavie, Tim Demuth, Dominique B. Hoelzinger, Jessica L. Rennert, Ruth Bristol, Satoko Nakada, Jean C. Zenklusen, Howard A. Fine, Thomas Mikkelsen, Michael E. Berens
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

1842 

Clinical management of patients with glial tumors is confounded by the propensity of these malignant cells to disperse into the brain, frequently seeding distant sites of recurrence. While this represents a central behavior in the malignant progression of these cells, dispersion is poorly addressed by current therapies. Failure to manage these invading cells leaves patients vulnerable to recurrence. We hypothesize that the invasive behavior of glioma cells is driven by a distinct gene expression profile, and that among the invasion-associated genes are novel therapeutic targets. The aim of this study is to broaden the scope of a pilot study that successfully identified genes previously unassociated with glioma invasion (Hoelzinger et al 2005), and to mature the biological validation of candidate genes using 2-dimenstional and 3-dimensional endpoints of glioma dispersion. Whole human genome expression profiling of stationary and dispersive cells in glioma biopsy specimens (n=20) isolated by laser capture microdissection (LCM) was performed. Genes consistently differentially expressed between core and rim across the majority of specimens were validated by QRT-PCR using RNA isolated from an additional 20 biopsy specimens from which core and rim cells were collected. As paradigmatic candidate genes discovered using in vitro dispersion assays, connective tissue growth factor (CTGF) and mitogen activated protein kinase kinase 3 (MKK3) validated as invasion markers in array data from clinical biopsy dispersion specimens, as well as in newly-processed clinical material. Immunohistochemistry on glioma invasion TMA slides support a role for heightened expression of CTGF and MKK3 in invasive glioma cells. Furthermore, CTGF and MKK3 served as prognostic markers for patient survival in an expression data set of 176 primary glial tumors. Our results demonstrate that biopsy-based LCM-collected glioma core and rim cells can be used as a discovery platform for identifying novel genes that may serve as prognostic markers or therapeutic targets in the setting of malignant glial tumors. A key driver for progress in maturing candidates into therapeutic targets on invasive glioma cells is an ability to validate biological effects using mid- and high-throughput assays of glioma dispersion. Supported by NS42262 and CA085139.
THE HEALTH CENTRES OF HARLOW
Authors: Charles Taylor, J.D. Huntley, A.G.C. Findlater, M.M. Keen, J.C. Busby, J. Meyrick, S. Dyakowski, R.E. Bracewell, T.G. Robson, G.G. Stewart, F.G. Brown, Stephen Taylor
Journal: The Lancet (1955)
Abstract 3774: Reduced Hyperemic Myocardial Blood Flow in Hypertrophic Cardiomyopathy: New Insights from Multi-Parametric Magnetic Resonance Imaging
Authors: Steffen E Petersen, Lucy E Hudsmith, Michael Jerosch-Herold, Matthew D Robson, Jane M Francis, Helen A Doll, Joseph B Selvanayagam, Stefan Neubauer, Hugh Watkins
Journal: Circulation (2006)
Pulmonary Vein Antral Isolation Using an Open Irrigation Ablation Catheter for the Treatment of Atrial Fibrillation
Authors: Mohamed H. Kanj, Oussama Wazni, Tamer Fahmy, Sergio Thal, Dimpi Patel, Claude Elayi, Luigi Di Biase, Mauricio Arruda, Walid Saliba, Robert A. Schweikert, Jennifer E. Cummings, J. David Burkhardt, David O. Martin, Gemma Pelargonio, Antonio Dello Russo, Michela Casella, Pietro Santarelli, Domenico Potenza, Raffaele Fanelli, Raimondo Massaro, Giovanni Forleo, Andrea Natale
Journal: Journal of the American College of Cardiology (2007)

We sought to test how catheter ablation using an open irrigation catheter (OIC) compares with standard catheters for pulmonary vein antrum isolation. Open irrigation catheters have the advantage of delivering greater power without increasing the temperature of the catheter tip, which enables deeper and wider lesions without the formation of coagulum on catheters. Catheter ablation was performed using an 8-mm catheter (8MC) or an OIC. Patients were randomized to 3 groups: 8MC; OIC-1, OIC with a higher peak power (50 W); and OIC-2, OIC with lower peak power (35 W). A total of 180 patients were randomized to the 3 treatment strategies. Isolation of pulmonary vein antra was achieved in all patients. The freedom from atrial fibrillation was significantly greater in the 8MC and OIC-1 groups compared with the OIC-2 group (78%, 82%, and 68%, respectively, p = 0.043). Fluoroscopy time was lower in OIC-1 compared with OIC-2 and 8MC (28 ± 1 min, 53 ± 2 min, and 46 ± 2 min, respectively, p = 0.001). The mean left atrium instrumentation time was lower in the OIC-1 compared with the OIC-2 and 8MC groups (59 ± 3 min, 90 ± 5 min, and 88 ± 4 min, respectively, p = 0.001). However, there was a greater incidence of "pops" in the OIC-1 (100%, 0%, 0%, p < 0.001) along with higher incidences of pericardial effusion (20%, 0%, 0%, p < 0.001) and gastrointestinal complaints (17% in OIC-1, 3% in 8MC, and 5% in OIC-2, p = 0.031). Although there was a decrease in fluoroscopy and left atrium instrumentation time with the use of OIC at higher power, this setting was associated with increased cardiovascular and gastrointestinal complications.
Trends in emergency admissions
Authors: A. Volans, O. Blatchford, S. Capewell, M. Blatchford
Journal: BMJ (1999)

Editor—Morgan et al report that they find little evidence for a rise in emergency admissions from NHS data returns.1 Their conclusion is that much of the increase in admissions is due to internal transfer between consultants generating multiple finished consultant episodes for an individual patient's admission. My memory suggests that this was a prediction raised in letters to the BMJ when the finished consulting episode first became a recognised measure of hospital activity.

In accident and emergency our level of information technology is often more basic and our workload is dependent on the number of people passing through the department. I have simple number data for the accident and emergency departments that I have worked in during the period in question (figure). In two departments there has been an 85% increase in the number of patients admitted. The percentage of patients admitted from the total seen in the departments has risen in all from 11% in the late 1980s to 17% in the late 1990s. 

From the accident and emergency medicine view, more patients are attending the departments and more of these patients are admitted despite, or perhaps because of, an increase in the seniority of the doctors who receive them. During this period the specialty of accident and emergency medicine has matured, with the expansion of training schemes, an increase in the number of consultants, and the development of its own faculty.

If official statistics do not show the trends seen by the simple counting of patients through a department, where does the discrepancy lie? Are we on the shop floor incorrect in our assessment of the workload, or does the processing of the data returned from our departments somehow lose the message contained?
2-Year Follow-Up of a Randomized Controlled Trial of Everolimus- and Paclitaxel-Eluting Stents for Coronary Revascularization in Daily Practice
Authors: Pieter C. Smits, Elvin Kedhi, Kees-Jan Royaards, Kaiyum Sheik Joesoef, Jochem Wassing, Tessa A.M. Rademaker-Havinga, Eugene McFadden
Journal: Journal of the American College of Cardiology (2011)
HEMATOPORPHYRINURIA: REVIEW OF LITERATURE AND REPORT OF A CASE OF CHRONIC TYPE
Authors: S LEVY, R J KLEIN
Journal: Annals of Internal Medicine (1946)

Case Reports1 September 1946HEMATOPORPHYRINURIA: REVIEW OF LITERATURE AND REPORT OF A CASE OF CHRONIC TYPESOL LEVY, M.D., ROBERT J. KLEIN, M.D.SOL LEVY, M.D.Search for more papers by this author, ROBERT J. KLEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-3-520 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPorphyrins are chemical compounds participating in the normal pigment metabolism and occurring throughout the plant and animal worlds. They are of special interest in medicine because of their occurrence in hemoglobin, in bile-pigments, in chlorophyll, and in the widely distributed coloring matter, cytochrome. All porphyrins have a common chemical structure, namely four pyrrole rings bound by four additional carbon atoms, and are able to form compounds with metals. In the blood pigment the porphyrin is called protoporphyrin and this combined with iron and the protein fraction, globin, forms the basis for hemoglobin.The organism receives the porphyrin either directly or...Bibliography1. DUNCAN GG: Diseases of metabolism, 1943, W. B. Saunders Company, Philadelphia. CrossrefGoogle Scholar2. ELDAHL A: Case of acute porphyria developed during hospitalization, Acta med. Scandinav., 1938, xcvii, 415-419. Google Scholar3. FETTERHUMPHREYLONGENECKER FAACR: Acute idiopathic porphyria, U. S. Naval Med. Bull., 1944, xliii, 349-352. Google Scholar4. GARROD AE: Inborn errors of metabolism, 1923, H. Froude, Hodder and Stoughton, London. Google Scholar5. GEISSLER J: Zur Kenntnis der Porphyria acuta, Klin. Wchnschr., 1939, xviii, 378-380. CrossrefGoogle Scholar6. GÜNTHER H: Die Hematoporphyrie, Deutsch. Arch. f. klin. Med., 1911, cv, 89-146. Google Scholar7. KÜHNAU WW: Experimentelle Untersuchungen ueber die Beziehungen des Nikotinsaeureamids zum Porphyrinstoffwechsel und zur Lichtwirkung, Strahlentherapie, 1939, lxvi, 24-39. Google Scholar8. MASONCOURVILLEZISKIND VRCE: Porphyrins in human disease, Medicine, 1933, xii, 355-439. CrossrefGoogle Scholar9. NESBITTWATKINS SCH: Acute porphyria, Am. Jr. Med. Sci., 1942, cciii, 74-83. CrossrefGoogle Scholar10. ROSENBLUMJOLLIFFE LAN: Porphyrinuria in pellagra, Am. Jr. Med. Sci., 1940, cic, 853-858. CrossrefGoogle Scholar11. WATSON CJ: The porphyrins and their relation to disease: Porphyria, in Christian and MacKenzie's Oxford Medicine, 1938, iv, 1-34, Oxford University Press, New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 9, 1945.From the Medical Service of the Wesson Memorial Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1946Volume 25, Issue 3Page: 520-525KeywordsBloodGlobinsHemoglobinMedical servicesPorphyrinsProteins ePublished: 1 December 2008 Issue Published: 1 September 1946 PDF downloadLoading ...
Abstract 1916: Anatomic Relationship of the Left Atrium and the Esophagus in Patients Undergoing Catheter Ablation of Atrial Fibrillation
Authors: Shingo Maeda, Yasutoshi Nagata, Kenji Suzuki, Kiyoshi Ootomo, Kikuya Uno, Yoshito Iesaka
Journal: Circulation (2006)

Background: Left atrio-esophageal fistula has been reported as a rare but life-threatening complication of atrial fibrillation (AF) ablation. The purpose of this study was to describe the topograph...
Elevated serum levels of soluble interleukin-2 receptor: a marker of disease activity in the hypereosinophilic syndrome
Authors: L Prin, J. Plumas, Valérie Gruart, S. Loiseau, Delphine Aldebert, J Ameisen, A. Vermersch, P. Fenaux, O Bletry, Monique Capron
Journal: Blood (1991)
ORIGINAL A RTICLE Association between physical performance characteristics and independence in activities of daily living in middle-aged and elderly men
Authors: Marjolein Em den Ouden, Marieke J Schuurmans, Ilse Ema Arts, Yvonne T van der Schouw
Journal: Circulation (2012)

Results: After adjustment for confounders, higher walking speed (OR = 2.96, 95% CI 1.31–6.72) and shorter time to carry out the chair stand test (OR = 0.84, 95% CI 0.76–0.94) were associated with a higher probability of being independent in activities of daily living (ADL). Borderline significant associations were found for higher lung function and higher leg strength with higher probability of being independent in ADL. No associations were found for grip strength, physical performance score, standing balance and physical activity.
Improvement Of The Efficacy Of Azacitidine At a Fixed Dosing Schedule Of 75mg/m2/Day For 5 Days, Followed By 21 Days Drug-Off In Higher Risk Myelodysplastic Syndromes
Authors: Taiichi Kyo, Kouhei Kyo, Ryouta Imanaka, Mitsuhiro Itagaki, Tetsuro Ochi, Takeshi Okatani, Koji Iwato, Yuta Katayama, Hideki Asaoku
Journal: Blood (2013)
Abstract 16687: The Incidence and Etiology of GI Bleeding in Patients Supported by Continuous Flow Left Ventricular Assist Device
Authors: Nir Uriel, Reem Sharaiha, Lindsay Murray, Jonathan Yang, Kalpana M Devaraj, Paolo C Colombo, Daniel B Sims, Jose Gonzalez-Costello, Hiroo Takayama, Donna Mancini, Yoshifumi Naka, Ulrich P Jorde
Journal: Circulation (2011)

Introduction Gastrointestinal (GI) bleeding is a frequent adverse event reported with continuous flow LVADs which may be explained by acquired von Willebrand disease and antithrombotic therapy. The aim of this study was to determine the incidence and etiology of GI bleeding among patients supported by a HeartMate II (HM II) LVAD. Methods A retrospective chart review was performed for all HM II patients implanted from 2004 to 2011. GI work-up included gastroscopy, colonoscopy, capsule studies, and small bowel enteroscopy and was reviewed by a gastroenterologist and a pathologist. GI bleeding was defined as occult or obvious blood in the stool with concomitant drop in hemoglobin. Results 142 patients aged 56.7±14.9 years were implanted with a HM II. 77% of patients were male and the etiology was ischemic cardiomyopathy in 44%. 74% of LVADs were placed as a bridge to transplant. The rate of GI bleeding was 0.36 events / year. A total of 51 events occurred in 28 patients. The indications for GI work-up were melena (46% of patients), hematochezia (14%), heme-positive stool (14%) and iron deficiency anemia (25%). Full GI work-up (gastroscopy, colonoscopy and capsule study) was performed in 7 patients; 12 patients had gastroscopy and colonoscopy only; and 7 underwent only gastroscopy. The source of bleeding was identified in 71% of patients. Duodenal ulcer was the most prevalent identified source and occurred in 21% of patients (see figure). Only 5 patients had therapeutic interventions performed. Gastric biopsy was performed in 7 patients of which 6 had reactive features including mucous depletion, foveolar hyperplasia, fibromuscular hyperplasia of the stroma, and dilated or congested capillaries. Conclusions A high incidence of GI bleeding was found among patients supported with a continuous flow device, with gastric ulcers as the most prevalent etiology. Evaluation for H. pylori infection and proton pump inhibitor use should be studied in continuous flow LVAD patients.
J-Shaped Association Between QTc Interval Duration and the Risk of Atrial Fibrillation
Authors: Jonas Bille Nielsen, Claus Graff, Adrian Pietersen, Bent Lind, Johannes Jan Struijk, Morten Salling Olesen, Stig Haunsø, Thomas Alexander Gerds, Jesper Hastrup Svendsen, Lars Køber, Anders Gaarsdal Holst
Journal: Journal of the American College of Cardiology (2013)
Features of pulmonary involvement in patients with diffuse connective tissue diseases depending on a nosological form
Authors: Dina Petrova, Yakov Shoikhet, Andrei Dorokhov, Sergei Berestov
Journal: European Respiratory Journal (2011)

The objective is to study features of pulmonary involvement in patients with diffuse connective tissue diseases (DCTD) depending on a nosological form.   Materials and methods:  Retrospective cohort study of 1363 patients with DCTD. Exclusion criteria: concomitant bronchopulmonary pathology, malignant neoplasms. Standard clinical examination, electrocardiography, echocardiogram, spirometry, X-ray study, high resolution computed tomography, ultrasonic scanning of pleura were made.   Results:  The involvement of respiratory system was found in 56 (4,11%) of 1363 examined patients. The patients with systemic lupus erythematosus (SLE) - 25 (44,6%), rheumatoid arthritis (RA) – 19 (33,9%) and systemic scleroderma (SS)- 9 (16,1%) prevailed.  In SLE patients pulmonary involvement was commonly manifested by lupus pleuritis (36,0%), pneumonitis (28,0%), bronchoobstructive syndrome (12,0%), pulmonary hypertension (8,0%) and diffuse interstitial pulmonary fibrosis (4,0%). In three patients (12,0%) various combinations of pleuritis, pneumonitis, bronchoobstructive syndrome and signs of interstitial diffuse pulmonary fibrosis were diagnosed. In RA patients, in 100,0% of cases the involvement of respiratory system included bronchoobstructive syndrome manifestations, while in SS patients– fibrosing avleolitis.   Conclusion:  In 100,0% cases the involvement of respiratory system with bronchoobstructive syndrome manifestations was more characteristic for RA patients, while for SS patients– fibrosing avleolitis. Pulmonary involvement in SLE patients is more heterogeneous, presented by pleuritis, pneumonitis, bronchoobstructive syndrome and their combinations.
Abstract 2399: Low Hospital Mortality Of Acute Myocardial Infarction In Cslinical Practice Due To Optimized Guideline Oriented Treatment: Results Of The Optami-registry
Authors: Anselm K Gitt, Harm Wienbergen, Uwe Zeymer, Frank Towae, Martin G Gottwik, Guenter Breithardt, Jochen Senges
Journal: Circulation (2007)

Background: Hospital mortality of STEMI in recent randomized trials as ASSENT IV ranges between 3.5 and 6.0%. Although registry data have shown a constant improvement of myocardial infarction outcome over the past years due to better implementation of guidelines for the management of acute myocardial infarction, hospital mortality in clinical practice still was much higher than in the selected patient population of randomized trials. Can ongoing registries in clinical practice as quality assurance programmes further reduce hospital mortality of acute myocardial infarction? Methods: The OPTAMI Register (Optimized Therapy of Acute Myocardial Infarction) enrols consecutive patients with STEMI or NSTEMI in 33 Centres (27 with cathlab facilities) in Germany to document patient characteristics, acute therapy as well as hospital outcome. All centres are provided benchmark reports for internal quality control. Results: Out of 1139 enrolled patients, 629 (55%) presented with STEMI and 510 (45%) with NSTEMI. Patients with NSTEMI were older, more often female and had a significantly higher prevalence of relevant comorbidities. OPTAMI documented an extraordinary high rate of primary PCI in STEMI as well as a high rate of early invasive strategy with PCI &lt;48h in NSTEMI. In both groups, adherence to guidelines for the acute adjunctive medical treatment including antiplatelet therapy, betablockers, ACE-inhibitors and statins was higher than ever documented in any German MI registry. Hospital mortality was 4.0% in consecutive patients with STEMI and 3.9% in consecutive patients with NSTEMI. Conclusion: Preliminary data of the ongoing OPTAMI Registry demonstrate that in selected cnetres (mainly with cath lab facilities) hospital mortality in clinical practice can be reduced to levels of randomised controlled trials by adherence to practice guidelines for the management of acute myocardial infarctions.
Abstract 5582: Impact of a Concurrent Chronic Total Occlusion on Long-term Mortality in Hospital Survivors after ST Elevation Myocardial Infarction
Authors: Bimmer E Claessen, Rene J van der Schaaf, Karel T Koch, jan Baan, Jan G Tijssen, Robbert J de Winter, Jan J Piek, Jose P Henriques
Journal: Circulation (2008)

Background: Patients with multivessel disease (MVD) constitute a patient group with a high risk of mortality after STEMI. Recently, it was reported that the higher mortality in patients with MVD is determined by the presence of a chronic total occlusion (CTO) in a noninfarct-related artery. Due to the higher risk profile, the in-hospital mortality rate accounted for this unfavorable outcome, moreover, multivariate analysis did not correct for residual left ventricular ejection fraction (LVEF). Therefore, we studied the effect of a concurrent CTO on long-term mortality, excluding deaths in the first 30 days and correcting for LVEF. Methods: Between 1997 and 2005, we admitted 3309 patients with STEMI treated with primary PCI. We categorized patients as having single vessel disease (SVD), MVD without CTO and CTO based on the angiogram before PCI. LVEF was assessed with echocardiography by global assessment of ejection fraction within 30 days after primary PCI and classified as ≤40% or &gt;40%. Stepwise Cox regression was used for multivariate analysis. Results: LVEF data were available for 1538 patients, of which 1485 (97%) survived the first 30 days after STEMI. SVD was present in 1013 patients (68%), MVD without CTO in 325 patients (22%) and a concurrent CTO in 147 patients (10%). Median duration of follow-up was 3.5 years (IQR 2.1–5.2 years). A total of 104 patients (7.0%) died; 61 (6.0%) in the SVD group, 25 (7.7%) in the MVD group and 18 (12%) in the CTO group (p=0.02). Median time to death was 2.1 years. After correction for the presence of MVD without CTO and differences in baseline variables (age&gt;60 years, residual LVEF ≤40%, diabetes, hypercholesterolemia, smoking, previous MI and shock) the presence of a CTO in a noninfarct-related artery is an independent risk factor for death (Hazard ratio (HR) 1.7, 95% CI 1.0 –2.8, p=0.04). Other independent risk factors are age &gt;60 years (HR 3.0, 95% CI 2.0 – 4.7, p&lt;0.01) and residual LVEF ≤40% (HR 2.3, 95%CI 1.5–3.4, p&lt;0.01) Conclusion: After primary PCI, the presence of a CTO in a noninfarct-related vessel, and not the mere presence of MVD, is a strong and independent risk factor for long-term mortality even when adjusted for residual LVEF ≤40% and excluding deaths in the first 30 days.
Barriers to managing heart failure in primary care
Authors: R. C Davis
Journal: BMJ (2003)

Editor—Fuat et al surveyed attitudes towards managing heart failure in general practice.1 Points of particular note included difficulties in assessing subtle early signs of heart failure, difficulties in interpreting echocardiography reports, and concerns about the number of drugs recommended for patients with heart failure.

This study further strengthens the case for specialist heart failure clinics as outlined in the national service framework for coronary heart disease.2 Such clinics have a multidisciplinary team consisting of physicians (specialist and primary care), specialist nurses, and cardiac technicians, and these teams facilitate a coordinated approach to diagnosing, assessing, and managing heart failure. Objective evidence of cardiac dysfunction may be obtained and interpreted by a cardiologist, with the subsequent formulation of a treatment strategy.

We believe that this is preferable to open access echocardiography services, with the difficulties in interpretation highlighted by Fuat et al.1 Specialist dedicated nursing provides a crucial bridge between hospital and community care, allowing continued clinical assessment and appropriate titration of drug treatment, as well as continued patient education. Such nursing has been associated with a significant reduction in hospital readmission for heart failure.3 Widespread awareness of current treatment guidelines seems to be lacking in primary care; dedicated nursing services can be instrumental in implementing guidelines.

Heart failure is thought to invariably affect elderly people. This is simply not true. Clearly the disease becomes more prevalent with age, but diagnosis is delayed in many young patients with dilated cardiomyopathy because of this perception.

Heart failure has a high prevalence and is associated with a terrible prognosis, despite the availability of evidence based treatments. General practitioners are at the sharp end of an escalating problem, and specialist clinics provide invaluable support for the growing burden of chronic heart failure.