tbuckley/cabot-search huggingface dataset:
Unilateral Nodular Adrenal Hyperplasia Mimicking Endometrial Cancer Metastasis on 18F-FDG PET/CT After Immunochemotherapy
Authors: Hui Li, Le Song, Meng Wang, Kai Yang, Yan Wan
Journal: Clinical Nuclear Medicine (2025)

Unilateral nodular adrenal hyperplasia after immunochemotherapy is extremely rare. We reported a 70-year-old woman with endometrial cancer who underwent 18 F-FDG PET/CT to evaluate the immunochemotherapy response. Compared with the baseline, follow-up PET/CT revealed a newly hypermetabolic nodule in the left adrenal gland, initially suspected to be metastatic. However, surgical resection and pathology confirmed it as adrenal hyperplasia. This case highlights the importance of recognizing unilateral nodular adrenal hyperplasia as a rare imaging finding mimicking metastasis following immunochemotherapy, which should be considered in the differential diagnosis.
68Ga-Trivehexin Uptake in Brown Tumors in Hyperparathyroidism
Authors: Siven Kar, Vikram R Lele, Nusrat Shaikh
Journal: Clinical Nuclear Medicine (2025)

We present a 54-year-old woman with chronic kidney disease, hypercalcemia, and hyperparathyroidism, who exhibited multiple osteolytic lesions and a suspicious parathyroid adenoma. 18 F-FDG PET/CT revealed increased metabolic activity in the lytic lesions, raising suspicion for multiple myeloma or brown tumors. A biopsy confirmed brown tumors. Subsequent 68 Ga-Trivehexin PET/CT showed intense αvβ6-integrin expression in the parathyroid adenoma and moderate uptake in the brown tumors. This highlights the potential utility of 68 Ga-Trivehexin in the characterization of osteolytic lesions in hyperparathyroidism.
CT, I-123-Ioflupane SPECT, and Integrated FDG PET-MRI of a Patient With Fahr Disease
Authors: James Ryan Loftus, Kent P. Friedman, Thomas M. Wisniewski, Timothy M. Shepherd
Journal: Clinical Nuclear Medicine (2025)

Fahr disease is a rare neurodegenerative syndrome characterized by abnormal symmetric calcium deposition in the white matter, cerebral cortex, deep gray, and cerebellar nuclei. The characteristic CT pattern is well known, but descriptions of molecular imaging in Fahr disease remain sparse. We present the characteristic imaging patterns of Fahr disease by CT, I-123-Ioflupane SPECT, and integrated FDG PET/MRI in a single patient.
Management of Immune Tolerant Chronic Hepatitis B
Authors: Mai M. Kilany, Milan J. Sonneveld, Jordan J. Feld, Harry L.A. Janssen
Journal: Hepatology (2025)

The immune-tolerant (IT) phase of chronic hepatitis B (CHB) is a distinct stage of infection, characterized by high hepatitis B virus (HBV) replication, normal alanine aminotransferase (ALT) levels, and minimal liver inflammation. Despite its classification as a benign phase, growing evidence challenges this notion, revealing immune activation, HBV DNA integration, and potential oncogenic processes even in the absence of elevated ALT. The IT phase’s prolonged high viral replication raises concerns about its implications for hepatocellular carcinoma (HCC) risk. Histological studies show that significant inflammation and fibrosis may exist in patients meeting IT criteria, suggesting that the current definitions may underestimate disease activity. Treatment during the IT phase remains controversial, with international guidelines largely recommending against antiviral therapy due to its limited efficacy and potential risks. However, subsets of IT patients may benefit from early intervention. The risks and benefits of therapy in IT CHB are not fully understood, and the lack of consensus regarding treatment thresholds further complicates clinical decision-making. This review highlights the importance of redefining IT CHB to include virological and histological parameters and calls for long-term studies to clarify the role of therapy in reducing fibrosis progression and HCC risk. A more precise understanding of the IT phase is essential to balance the risks of treatment against its potential benefits and to inform future therapeutic strategies.
Use of Terbium-161 [161Tb]Tb-DOTATATE in Recurrent Paraganglioma
Authors: Nihaad Jacobs, Tariq Solomon, Olumayowa Kolade, Khanyisile Hlongwa, Stuart More
Journal: Clinical Nuclear Medicine (2025)

This report explores the application of terbium-161 [( 161 Tb)Tb] DOTATATE in the case of a 31-year-old man with recurrent paraganglioma. Due to liver metastases and inoperable nodal disease, he was treated with lutetium-177 [( 177 Lu)Lu] DOTATATE, resulting in decreased chromogranin A levels and stable disease. Logistical challenges with lutetium-177 acquisition resulted in treatment with [ 161 Tb]Tb-DOTATATE, demonstrating prominent lesion uptake, further reduction in chromogranin A levels, and no adverse effects. He maintains an excellent functional status and 19 months of progression-free survival after 3 total cycles of [ 177 Lu]Lu and [ 161 Tb]Tb-DOTATATE, suggesting [ 161 Tb]Tb-DOTATATE as a promising alternative radionuclide therapy for advanced neuroendocrine tumors.
18FDG PET/MRI in Histiocytic Sarcoma of the Spinal Canal
Authors: Kohei Hirota, Feibi Zeng, Junko Inoue Inukai, Munenobu Nogami, Takamichi Murakami
Journal: Clinical Nuclear Medicine (2025)

Histiocytic sarcoma is a malignant neoplasm of mature histiocytes that rarely involves the central nervous system. A 49-year-old man presenting with a mass filling the lumbar spinal canal underwent 18 F-FDG PET/MRI. Fused PET/MRI images showed intense FDG uptake in the mass, as well as uptake in the cerebellopontine angle and cervical lymph nodes. Biopsy of the spinal lesion showed histiocytic sarcoma. This is the rare case report of PET/MRI performed for histiocytic sarcoma demonstrating changes in FDG uptake during chemotherapy. This case highlights the utility of PET imaging for evaluating the extent of lesions and treatment efficacy for histiocytic sarcoma.
Circlet Sign
Authors: Srinivas Ananth Kumar, Vishnu Kumar Selvaraj, Madhur Kumar Srivastava
Journal: Clinical Nuclear Medicine (2025)

Peptide receptor radionuclide therapy has revolutionized the management of somatostatin receptor-positive metastatic neuroendocrine tumours. Treating nuclear medicine physicians must be aware of the radiation hazards posed by radioactive contamination and the imaging fallacies attributable to radioactive contamination on posttherapy planar imaging. The image fallacies, if not properly looked upon, upstage the disease. Also, radioactive contamination with body fluids on any external structure in close contact with the patients poses a prolonged radiation hazard. The authors in this present research demonstrate image fallacy due to radioactive urinary contamination on 177 Lu-DOTATATE posttherapy imaging.
Pitfall in 68Ga-PSMA PET/CT Interpretation
Authors: Ya Liu, Kan Wang, Jingguang Pu, Haoyuan Ding, Zhanwen Huang
Journal: Clinical Nuclear Medicine (2025)

68 Ga-Prostate-Specific Membrane Antigen (PSMA) is excreted mainly through the urinary system, but also partly through biliary system. Herein, we present such a case in a man with prostate cancer. The 68 Ga-PSMA PET/CT revealed increased uptake of 68 Ga-PSMA in bone metastases. Besides, increased 68 Ga-PSMA uptake in the common hepatic duct and common bile duct was observed, which resolved spontaneously in the delayed imaging.
A Rare Case of Osteoid Osteoma of the Distal Physis of the Fibula Confirmed by Bone SPECT/CT Scanning
Authors: Mohammad Hadi Samadi, Susan Khezri, Salman Soltani, Seyyed Mohammad Ata Saharifi Dalooei, Atena Aghaee
Journal: Clinical Nuclear Medicine (2025)

A 13-year-old girl presented with a 2-year history of progressive left ankle pain, limited range of motion, and swelling over the left lateral malleolus. Initial hematologic and rheumatologic lab tests were normal. MRI showed edema in the distal part of the left fibula. The patient was referred to our department due to inconsistencies in these findings. A 3-phase bone scan demonstrated increased activity in the distal physis of the left fibula, and SPECT/CT imaging indicated a possible osteoid osteoma. This diagnosis was confirmed through surgical resection and pathologic findings.
Chronic Alteration in Cerebral FDG Metabolism After MRI-guided HIFU for Essential Tremor
Authors: Nghi C. Nguyen, Alexander Asturias, Fabricio Stewan Feltrin, Orhan K. Oz, Bhavya R. Shah
Journal: Clinical Nuclear Medicine (2025)

A 74-year-old man with a history of monoclonal gammopathy of undetermined significance (MGUS) underwent surveillance whole-body 18 F-FDG PET 2 weeks before MRI-guided high-intensity focused ultrasound (MRgHIFU) of the left dentato-rubro-thalamic tract (DRTT) for his right-hand dominant, debilitating essential tremor. This baseline FDG PET showed normal thalamic metabolism. At 12 months post-treatment, FDG PET scan revealed a small focus of left thalamic hypometabolism, which corresponded to the left DRTT ablation area seen on post-treatment MRI. The patient was tremor-free in his right hand at 1-year follow-up. This case documents the chronic effects of MRgHIFU on cerebral FDG metabolism.
Unveiling Ovarian Cancer With [18F]FDG and [68Ga]Ga-FAPI-46 PET/CT
Authors: Morten Bentestuen, Camilla Sylvest, Bence Gabor Szilvasy, Helle D. Zacho
Journal: Clinical Nuclear Medicine (2025)

A 71-year-old woman presented with fatigue, dyspnea, and weight gain, suggestive of a serious systemic disease. CT revealed a large pericardial effusion, and subsequent [ 18 F]FDG PET/CT showed focal areas of elevated FDG uptake in the pericardium and moderate, symmetric FDG uptake in normal-sized ovaries. Pericardial effusion cytology indicated a gynecological malignancy. Additional [ 68 Ga]Ga-FAPI-46 PET/CT demonstrated more distinct uptake in the pericardium and lymph nodes. Histopathology of ovarian surgical specimens confirmed poorly differentiated ovarian cancer. This case highlights the utility of FDG PET/CT in evaluating pericardial effusion of unknown etiology and introduces the potential role of FAPI PET/CT in such scenarios.
Atypical Presentation of Liver Metastasis in Medullary Thyroid Carcinoma: Variable Pattern and Interlesional Heterogeneity Observed on 18F-FDG, 68Ga-DOTATATE, and 68Ga-DOTA-FAPI-04 PET/CT
Authors: Shyam Kumar Ravada, Rahul Vithalrao Parghane, Gaurav Malhotra, Sandip Basu
Journal: Clinical Nuclear Medicine (2025)

Metastatic medullary thyroid carcinoma (MTC) can exhibit variable progression, with liver metastases occurring in up to 62% of cases. We report an unusual case of 50-year-old man with progressive MTC and atypical hypodense metastasis in the left lobe of liver that showed no tracer avidity on conventional 18 F-FDG and 68 Ga-DOTATATE PET/CT but was intensely avid on 68 Ga-DOTA-FAPI-04 PET/CT, implying a possible role of FAPI PET/CT imaging in diagnosing unusual metastatic lesions that may be missed on conventional PET imaging and also its theranostic potential for future management.
68Ga-FAPI-04 PET/CT Imaging of Multiple Lymph Node Metastases of Gastric Hepatoid Adenocarcinoma
Authors: Weidong Gong, Huajun Liu, Zongyin Yin, Fan Zhou, Chunyin Zhan
Journal: Clinical Nuclear Medicine (2025)

Hepatoid adenocarcinoma is a rare special type of adenocarcinoma with hepatic differentiation that occurs in extrahepatic organs or tissues. We present 68 Ga-FAPI-04 findings of multiple lymph node metastases of gastric hepatoid adenocarcinoma in a 60-year-old man. In this case, 68 Ga-FAPI PET/CT showed increased FAPI activity in the primary gastric lesions and multiple lymph nodes throughout the body. Our findings suggest the potential value of 68 Ga-FAPI-04 in the diagnosis of hepatoid adenocarcinoma.
Potential Pancreatic Pitfall of 68Ga-FAPI-04
Authors: Qixin Wang, Shufan Xu, XiaoLiang Chen
Journal: Clinical Nuclear Medicine (2025)

A 77-year-old woman who had colon cancer surgery 2 years ago underwent 68 Ga-DOTA-FAPI-04 PET/CT imaging. The scan revealed nodules in liver segment II and pancreas tail, both demonstrating intense FAPI uptake. Postoperative pathology confirmed that the liver tumor was consistent with metastatic colorectal cancer, whereas the pancreatic tail nodule consisted of interlobular fibrous tissue hyperplasia with collagenous degeneration.
Safety and Efficacy of Topical Simvastatin Plus Cholesterol Cream vs Topical Simvastatin Cream Alone for Porokeratosis Ptychotropica: A randomized, single-blind, split-body, placebo-controlled investigator-initiated trial
Authors: Zhiming Chen, Yihe Liu, Hui Yu, Jing Li, Xin Huang, Ruiyu Xiang, Ran Mo, Hao Chen, Yong Yang
Journal: Journal of the American Academy of Dermatology (2025)
68Ga-DOTA-IBA Uptake in Meningioma and Liver Metastasis of Breast Cancer
Authors: Haoyuan Ding, Juan Liang, Lin Chen, Jiqing Xuan, Yue Chen
Journal: Clinical Nuclear Medicine (2025)

A 41-year-old woman with bone and liver metastasis of breast cancer was enrolled in our 68 Ga-labeled DOTA-ibandronic acid ( 68 Ga-DOTA-IBA) PET/CT tumor clinical trial. The examination revealed increased uptake of 68 Ga-DOTA-IBA in the multiple bone metastases. Unexpectedly, 68 Ga-DOTA-IBA uptake in meningioma and liver metastasis were also noted.
mRNA metabolism regulator human antigen R (HuR) regulates age-related hearing loss in aged mice
Authors: Siwei Guo, Jieying Cao, Guodong Hong, Yuning Song, Ming Xia, Peipei Li, Wei Yuan, Yu Xiao, Guoqiang Sun, Shuang Liu, Shengda Cao, Jieyu Qi, Xiuli Bi, Ziyi Liu, Yunhao Wu, Wen Li, Xiaoxu Zhao, Jiangang Gao, Renjie Chai, Xiaolong Fu
Journal: Nature Aging (2025)
Association of the circulating lipid panel, PCPro, with clinical outcomes in metastatic hormone-sensitive prostate cancer: post-hoc analysis of the ENZAMET Phase 3 randomised trial (ANZUP 1304).
Authors: H-M Lin, T Scheinberg, N Portman, R M N Kim, R Mellor, K Hunyh, A N Faulkner, N A Mellett, I D Davis, A Martin, D Sullivan, A Joshua, M McJannett, V Subhash, S Yip, A A Azad, I C Marschner, S A North, R S McDermott, K N Chi, M R Stockler, C J Sweeney, P J Meikle, L G Horvath
Journal: Annals of Oncology (2025)
Safety and efficacy of indocyanine green-guided laparoscopic lymphadenectomy for locally advanced gastric cancer: The CLASS-11 clinical trials
Authors: Chao-Hui Zheng, Ying-Bo Chen, Wen-Bin Yu, Li-Sheng Cai, Quan Wang, Yi-Hong Sun, Su Yan, Xian-Li He, Ze-Kuan Xu, Guo-Xin Li, Yan-Tao Tian, Chen Li, Bao-Gui Wang, Jia-Fu Ji, Yan-Chang Xu, Qing Zhong, Zhi-Yu Liu, Qi-Yue Chen, Ping Li, Jian-Wei Xie, Yao Liang, Zhi-Min Liu, Hai-Bo Qiu, Meng Wei, Zhi-Bo Yan, Chen-Bin Lv, Qiu-Xian Chen, Shuang Li, Ling-Xiao Zeng, Bo-Wen Huo, Zi-Yu Li, Xiang-Qian Su, Chang-Ming Huang
Journal: Cell Reports Medicine (2025)
MPXV infection activates cGAS-STING signaling and IFN-I treatment reduces pathogenicity of mpox in CAST/EiJ mice and rhesus macaques
Authors: Lin Zhu, Qi Liu, Yongzhi Hou, Baoying Huang, Dong Zhang, Zhe Cong, Jianrong Ma, Na Li, Jiahan Lu, Jingjing Zhang, Lingyan Zhang, Ting Chen, Qiang Wei, Jiangning Liu, Wenjie Tan, Jing Xue
Journal: Cell Reports Medicine (2025)
Targeting mitochondrial complex I of CD177+ neutrophils alleviates lung ischemia-reperfusion injury
Authors: Junqi Wu, Peigen Gao, Chenlu Yang, Fenghui Zhuang, Yunzhe Luo, Feng Wen, Panyu Zhang, Long Wang, Huikang Xie, Chenyang Dai, Deping Zhao, Chongwu Li, Haohao Deng, Ziqing Deng, Chang Chen
Journal: Cell Reports Medicine (2025)
Chikungunya virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans
Authors: Rimjhim Agarwal, James Chang, Fernanda H Côrtes, Calvin Ha, John Villalpando, Izabella N Castillo, Rosa Isela Gálvez, Alba Grifoni, Alessandro Sette, Claudia M Romero-Vivas, Mark T Heise, Lakshmanane Premkumar, Andrew K Falconar, Daniela Weiskopf
Journal: Cell Reports Medicine (2025)
Reactivating cGAS-STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors
Authors: Jia-Lu Shan, Kai-Ming Zhang, Wen-Qing Zhong, Xiao-Yu Yang, Zhi-Ling Li, Yun Huang, Tian Du, Dong Yang, Jia-Hong Tang, Yu-Hong Chen, Hai-Liang Zhang, Xiao-Feng Zhu, Rong Deng
Journal: Cancer Research (2025)

Abstract NRAS is commonly mutated in several different types of human cancer. NRAS-mutant tumors are aggressive and associated with poor outcomes. Although the development of targeted therapies as well as immune checkpoint inhibitors has led to a substantial improvement in the overall survival of patients with NRAS wild-type tumors, current therapies for NRAS-mutant cancers are limited. Here, analysis of RNA-sequencing data revealed a downregulation of the type I interferon response in NRAS-mutant tumors compared with NRAS wild-type tumors, which was associated with poor prognosis in NRAS-mutant melanoma. Knockdown of mutant NRAS, but not wild-type NRAS, enhanced the activation of cGAS-STING signaling. The formation of a trimeric complex between TBK1, STING, and IRF3, which is required for the activation and nuclear translocation, was blocked in NRAS-mutant tumor cells. Inactivation of innate immune signaling by mutant NRAS altered cytokine production, resulting in cell autonomous and non-cell autonomous signaling to prevent tumor cell death and in evasion of tumor immune surveillance. Screening of drugs for the ability to stimulate the release of CXCL10 revealed that SOS1 inhibitors reactivated cGAS-STING signaling in NRAS-mutant tumor cells. Importantly, combining SOS1 inhibitors with STING agonists maximized the activation of cGAS-STING signaling and elicited an increased antitumor immune response in vitro and in vivo. Overall, this study provides insights into the regulation of anti-tumor immunity by mutant NRAS and uncovers a potential strategy for treating NRAS-mutant cancer.
Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer
Authors: Stephen L. DeAngelo, Liang Zhao, Sofia Dziechciarz, Myungsun Shin, Sumeet Solanki, Andrii Balia, Marwa O. El-Derany, Cristina Castillo, Yao Qin, Nupur K. Das, Hannah N. Bell, Joao A. Paulo, Yuezhong Zhang, Nicholas J. Rossiter, Elizabeth C. McCulla, Jianping He, Indrani Talukder, Billy Wai-Lung Ng, Zachary T. Schafer, Nouri Neamati, Joseph D. Mancias, Markos Koutmos, Yatrik M. Shah
Journal: Cancer Research (2025)

Abstract Ferroptosis is a non-apoptotic form of cell death driven by iron-dependent lipid peroxide accumulation. Colorectal cancer (CRC) cells feature elevated intracellular iron and reactive oxygen species (ROS) that heighten ferroptosis sensitivity. The ferroptosis inducer (S)-RSL3 ([1S,3R]-RSL3) is widely described as a selective inhibitor of the selenocysteine-containing enzyme (selenoprotein) glutathione peroxidase 4 (GPX4), which detoxifies lipid peroxides utilizing glutathione. However, through chemical controls utilizing the (R) stereoisomer of RSL3 ([1R,3R]-RSL3) that does not bind GPX4, combined with inducible genetic knockdowns of GPX4 in CRC cell lines, we revealed here that GPX4 dependency does not always align with (S)-RSL3 sensitivity, questioning the current characterization of GPX4 as the primary target of (S)-RSL3. Affinity pull-down mass spectrometry with modified (S)-RSL3 probes identified multiple selenoprotein targets, indicating broad selenoprotein inhibition. Further investigation of the therapeutic potential of broadly disrupting the selenoproteome as a therapeutic strategy in CRC showed that the selenoprotein inhibitor auranofin, an FDA-approved gold-salt, chemically induced oxidative cell death and ferroptosis in CRC models in vitro and in vivo. Similarly, genetic perturbation of ALKBH8, a tRNA-selenocysteine methyltransferase required for selenoprotein translation, suppressed CRC growth. In summary, these findings recharacterize the mechanism of (S)-RSL3 beyond GPX4 inhibition and establish selenoproteome disruption as a CRC therapeutic strategy.
Core GRADE 5: rating certainty of evidence—assessing indirectness
Authors: Gordon Guyatt, Alfonso Iorio, Hans De Beer, Andrew Owen, Thomas Agoritsas, M Hassan Murad, Ganesan Karthikeyan, Carlos Cuello, Manya Prasad, Kevin Kim, Dalal S Ali, Arnav Agarwal, Lars G Hemkens, Liang Yao, Monica Hultcrantz, Jamie Rylance, Derek K Chu, Per Olav Vandvik, Benjamin Djulbegovic, Reem A Mustafa, Linan Zeng, Prashanti Eachempati, Bram Rochwerg, Kameshwar Prasad, Victor M Montori, Romina Brignardello-Petersen
Journal: BMJ (2025)
Preterm and early-term delivery after heat waves in eight US states: A case-crossover study using the High-resolution Urban Meteorology for Impacts Dataset (HUMID)
Authors: Amy Fitch, Mengjiao Huang, Matthew Strickland, Andrew Newman, Christina Kalb, Joshua L. Warren, Xiaping Zheng, Howard Chang, Lyndsey Darrow
Journal: Environmental Health Perspectives (2025)

Heat wave frequency and intensity is increasing and this trend is more pronounced in urban areas. Heat waves may be acutely associated with early birth. To examine the acute relationship between heat waves and preterm (<37 weeks) and early-term (37-38 weeks) birth in eight states: California, Florida, Georgia, Kansas, Nevada, New Jersey, North Carolina, and Oregon. Daily mean temperatures from the novel High-resolution Urban Meteorology for Impacts Dataset (HUMID) were averaged by zip code tabulation area (ZCTA) and linked to singleton preterm and early-term births identified statewide from vital records. Heat waves were defined based on days exceeding the local 97.5%ile temperature threshold during the 4-day exposure window preceding birth. We conducted case-crossover (conditional logistic regression) state-specific analyses and pooled results using inverse-variance weighting to obtain summary effect estimates. We also calculated ORs adjusting for temporal changes in the pregnancy risk set, conducted an analysis excluding medically-induced early-term births, and modeled effects stratified by 97.5th mean temperature threshold categories. The analysis included 2,966,661 early-term and 945,869 preterm births occurring from May - September across the eight states from as early as 1990 to 2017. Results showed modestly elevated odds of early-term birth for heat waves occurring in the 4 days preceding birth. Pooled ORs (95%CIs) for 3- and 4-consecutive days above the 97.5th percentile mean temperature were 1.018 (1.011, 1.026) and 1.017 (1.005, 1.028), respectively. Preterm birth ORs were similar, but less precise; OR=1.015 (1.001, 1.029) and 1.019 (0.999, 1.041) for 3- and 4-consecutive days respectively. Estimated odds ratios tended to be stronger for ZCTAs in thesecond-lowest category of temperature threshold. Using fine-scale surface temperature data capturing urban-heat islands, we observed a modest acute overall effect of heat waves on preterm and early-term birth. https://doi.org/10.1289/EHP15953.
Executive summary for the China Kidney Disease Network (CK-NET) 2017–2018 Annual Data Report
Authors: Chao Yang, Bixia Gao, Fang Wang, Hong Chu, Jinwei Wang, Xiaoyu Sun, Ping Zhang, Hui Xu, Huijuan Mao, Changying Xing, Menghua Chen, Li Zuo, Yue Wang, Feng Yu, Hong Zhang, Haibo Wang, Jianghua Chen, Luxia Zhang, Ming-Hui Zhao
Journal: Kidney International (2025)

Chronic kidney disease (CKD) has become a public health issue. Rapid urbanization in China has been intimately linked to shifts in the spectrum of CKD, particularly as regards CKD related to diabetes mellitus. By amalgamating diverse data streams and harnessing cutting-edge technologies, the China Kidney Disease Network aspires to evolve into a comprehensive surveillance framework for kidney diseases in China. The China Kidney Disease Network 2017-2018 Annual Data Report is the fourth nationwide report produced by the China Kidney Disease Network team. Through the analysis of data from 3 large national databases and 4 provincial dialysis quality control centers, this report seeks to provide a robust foundation for understanding the current state of kidney disease in China. Specifically, in addition to providing epidemiological and economic data on CKD and dialysis from 2017 to 2018, hot topics such as environmental pollution and CKD, as well as digital intelligence in nephrology, have been addressed. This report could serve as a valuable resource for researchers, policymakers, and health care professionals alike, inspiring new ideas, fostering collaborations, and ultimately leading to improved outcomes for those affected by kidney diseases.