tbuckley/cabot-search huggingface dataset:
Transfusion and Anemia in Patients Undergoing Vascular Surgery
Authors: Michelle N. Manesh, Alexander D. DiBartolomeo, Helen A. Potter, Fred A. Weaver, Li Ding, Gregory A. Magee
Journal: JAMA Surgery (2024)

This cohort study examines the association between blood transfusion and major adverse cardiovascular events and mortality among people undergoing elective open vascular operations.
Concerns About Recurrence Rate for Ventral Hernia Repair
Authors: Anne P. Ehlers, Alex K. Hallway, Dana A. Telem
Journal: JAMA Surgery (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Intersection of Poverty and Rurality for Early-Onset Colorectal Cancer Survival
Authors: Meng-Han Tsai, Steven S. Coughlin, Jorge Cortes, Caroline A. Thompson
Journal: JAMA Network Open (2024)

This cross-sectional study examines poverty, rurality, and the intersection of persistent poverty and rurality on early-onset colorectal cancer survival among adults aged 18 to 49 years.
Parastomal Hernia Prevention Using Funnel-Shaped Intra-Abdominal Mesh Compared to No Mesh
Authors: Elisa Mäkäräinen, Heikki Wiik, Maziar Nikberg, Jyrki Kössi, Monika Carpelan-Holmström, Tarja Pinta, Kirsi Lehto, Marko Nikki, Jyri Järvinen, Pasi Ohtonen, Tero Rautio
Journal: JAMA Surgery (2024)

Prophylactic placement of a mesh has been suggested to prevent parastomal hernia. Evidence to support this practice is contradictory.
Outcomes of Patients With Traumatic Brain Injury Transferred to Trauma Centers
Authors: Sai Krishna Bhogadi, Collin Stewart, Hamidreza Hosseinpour, Adam Nelson, Michael Ditillo, Marc R. Matthews, Louis J. Magnotti, Bellal Joseph
Journal: JAMA Surgery (2024)

Wide variations exist in traumatic brain injury (TBI) management strategies and transfer guidelines across the country.
Latent Profiles of Childhood Adversity, Adolescent Mental Health, and Neural Network Connectivity
Authors: Felicia A. Hardi, Adriene M. Beltz, Vonnie McLoyd, Jeanne Brooks-Gunn, Edward Huntley, Colter Mitchell, Luke W. Hyde, Christopher S. Monk
Journal: JAMA Network Open (2024)

Adverse childhood experiences are pervasive and heterogeneous, with potential lifelong consequences for psychiatric morbidity and brain health. Existing research does not capture the complex interplay of multiple adversities, resulting in a lack of precision in understanding their associations with neural function and mental health.
First-Generation Antihistamines and Seizures in Young Children
Authors: Ju Hee Kim, Eun Kyo Ha, Boeun Han, Taehwan Han, Jeewon Shin, Kyu Young Chae, Seonkyeong Rhie, Man Yong Han
Journal: JAMA Network Open (2024)

The widespread use of antihistamines in children for treatment of common cold symptoms and their central nervous system effects, like drowsiness, underscore the importance of being aware of the associated risks.
Successful Prevention of Parastomal Hernia Formation With Intra-Abdominal Funnel-Shaped Mesh
Authors: Imran J. Anwar, Jacob A. Greenberg
Journal: JAMA Surgery (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia
Authors: Pedram Paragomi, Zhongjie Zhang, Sarah Krull Abe, Md. Rashedul Islam, Md. Shafiur Rahman, Eiko Saito, Xiao-Ou Shu, Bashir Dabo, Yen Thi-Hai Pham, Yu Chen, Yu-Tang Gao, Woon-Puay Koh, Norie Sawada, Reza Malekzadeh, Ritsu Sakata, Atsushi Hozawa, Jeongseon Kim, Seiki Kanemura, Chisato Nagata, San-Lin You, Hidemi Ito, Sue K. Park, Jian-Min Yuan, Wen-Harn Pan, Wanqing Wen, Renwei Wang, Hui Cai, Shoichiro Tsugane, Akram Pourshams, Yumi Sugawara, Keiko Wada, Chien-Jen Chen, Isao Oze, Aesun Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang, Hung N. Luu
Journal: JAMA Network Open (2024)

The global burden of obesity is increasing, as are colorectal cancer (CRC) incidence and mortality.
Comment on Risk of Cardiac Arrhythmias Among Climbers on Mount Everest—Reply
Authors: Thomas Pilgrim, Martina Rothenbühler, Kunjang Sherpa
Journal: JAMA Cardiology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Fear of Cancer Recurrence Among Survivors of Localized Cutaneous Melanoma—What’s in a Name?
Authors: Elliot H. Akama-Garren, Rebecca I. Hartman
Journal: JAMA Dermatology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Comment on Risk of Cardiac Arrhythmias Among Climbers on Mount Everest
Authors: Stefano Savonitto, Patrizio Sarto
Journal: JAMA Cardiology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Manganese boosts natural killer cell function via cGAS–STING mediated UTX expression
Authors: Qianyi Ming, Jiejie Liu, Zijian Lv, Tiance Wang, Runjia Fan, Yan Zhang, Meixia Chen, Yingli Sun, Weidong Han, Qian Mei
Journal: MedComm (2024)

Natural killer (NK) cells play a crucial role in both innate immunity and the activation of adaptive immunity. The activating effect of Mn
Genome profiling with targeted adaptive sampling long-read sequencing for pediatric leukemia
Authors: Shota Kato, Aiko Sato-Otsubo, Wataru Nakamura, Masahiro Sugawa, Ai Okada, Kenichi Chiba, Nao Takasugi, Tomoya Irikura, Moe Hidaka, Masahiro Sekiguchi, Kentaro Watanabe, Yuichi Shiraishi, Motohiro Kato
Journal: Blood Cancer Journal (2024)
Estimating the Acute Health Effects of Smoke Exposure from an Urban Factory Fire Accident: A Case Study of a Tire Factory Fire in Korea
Authors: Changwoo Han, Marnpyung Jang, Jaeyoung Yoon, Bolim Lee, Jaiyong Kim, Hoyeon Jang, Tarik Benmarhnia
Journal: Environmental Health Perspectives (2024)

A major industrial fire accident occurred in a tire manufacturing factory in Daejeon, Korea, on 12 March 2023 and lasted for 3 d, generating air pollutant emissions. Although evidence regarding the health effects of urban fires is limited, residents near tire factory may have experienced health hazards due to smoke exposure from fire plumes.
Pathophysiological insights into HFpEF from studies of human cardiac tissue
Authors: Ahmed U. Fayyaz, Muhammad Eltony, Larry J. Prokop, Katlyn E. Koepp, Barry A. Borlaug, Surendra Dasari, Melanie C. Bois, Kenneth B. Margulies, Joesph J. Maleszewski, Ying Wang, Margaret M. Redfield
Journal: Nature Reviews Cardiology (2024)
Patient‐derived ovarian cancer organoid carries immune microenvironment and blood vessel keeping high response to cisplatin
Authors: Yuqing Zhao, Chen Wang, Wei Deng, Lanyang Li, Jiping Liu, Yanghua Shi, Xiang Tao, Jian Zhang, Qi Cao, Chunhui Cai, Xinxin Han
Journal: MedComm (2024)

Ovarian cancer is high recurrence and mortality malignant tumor. The most common ovarian cancer was High-Grade Serous Ovarian Cancer. However, High-Grade Serous Ovarian Cancer organoid is rare, which organoid with patient immune microenvironment and blood vessels even absence. Here, we report a novel High-Grade Serous Ovarian Cancer organoid system derived from patient ovarian cancer samples. These organoids recapitulate High-Grade Serous Ovarian Cancer organoids' histological and molecular heterogeneity while preserving the critical immune microenvironment and blood vessels, as evidenced by the presence of
Conservation of antiviral systems across domains of life reveals immune genes in humans
Authors: Jean Cury, Matthieu Haudiquet, Veronica Hernandez Trejo, Ernest Mordret, Anael Hanouna, Maxime Rotival, Florian Tesson, Delphine Bonhomme, Gal Ofir, Lluis Quintana-Murci, Philippe Benaroch, Enzo Z Poirier, Aude Bernheim
Journal: Cell Host & Microbe (2024)
Isotype-aware inference of B cell clonal lineage trees from single-cell sequencing data
Authors: Leah L. Weber, Derek Reiman, Mrinmoy S. Roddur, Yuanyuan Qi, Mohammed El-Kebir, Aly A. Khan
Journal: Cell Genomics (2024)

Single-cell RNA sequencing (scRNA-seq) enables comprehensive characterization of the micro-evolutionary processes of B cells during an adaptive immune response, capturing features of somatic hypermutation (SHM) and class switch recombination (CSR). Existing phylogenetic approaches for reconstructing B cell evolution have primarily focused on the SHM process alone. Here, we present tree inference of B cell clonal lineages (TRIBAL), an algorithm designed to optimally reconstruct the evolutionary history of B cell clonal lineages undergoing both SHM and CSR from scRNA-seq data. Through simulations, we demonstrate that TRIBAL produces more comprehensive and accurate B cell lineage trees compared to existing methods. Using real-world datasets, TRIBAL successfully recapitulates expected biological trends in a model affinity maturation system while reconstructing evolutionary histories with more parsimonious class switching than state-of-the-art methods. Thus, TRIBAL significantly improves B cell lineage tracing, useful for modeling vaccine responses, disease progression, and the identification of therapeutic antibodies.
Proteo-metabolomics and patient tumor slice experiments point to amino acid centrality for rewired mitochondria in fibrolamellar carcinoma
Authors: Donald Long, Marina Chan, Mingqi Han, Zeal Kamdar, Rosanna K Ma, Pei-Yin Tsai, Adam B Francisco, Joeva Barrow, David B Shackelford, Mark Yarchoan, Matthew J McBride, Lukas M Orre, Nathaniel M Vacanti, Taranjit S Gujral, Praveen Sethupathy
Journal: Cell Reports Medicine (2024)
PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis
Authors: Yu Ping, Jiqi Shan, Haiming Qin, Feng Li, Jiao Qu, Ru Guo, Dong Han, Wei Jing, Yaqing Liu, Jinyan Liu, Zhangnan Liu, Jieyao Li, Dongli Yue, Feng Wang, Liping Wang, Bin Zhang, Bo Huang, Yi Zhang
Journal: Immunity (2024)
Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in atypical teratoid/rhabdoid tumors
Authors: Dennis S Metselaar, Michaël H Meel, Joshua R Goulding, Aimeé du Chatinier, Leyla Rigamonti, Piotr Waranecki, Neal Geisemeyer, Mark C de Gooijer, Marjolein Breur, Jan Koster, Sophie E M Veldhuijzen van Zanten, Marianna Bugiani, Niels E Franke, Alyssa Reddy, Pieter Wesseling, Gertjan J L Kaspers, Esther Hulleman
Journal: Cell Reports Medicine (2024)

Atypical teratoid/rhabdoid tumors (ATRTs) are highly malignant embryonal tumors of the central nervous system with a dismal prognosis. Using a newly developed and validated patient-derived ATRT culture and xenograft model, alongside a panel of primary ATRT models, we found that ATRTs are selectively sensitive to the nucleoside analog gemcitabine. Gene expression and protein analyses indicate that gemcitabine treatment causes the degradation of sirtuin 1 (SIRT1), resulting in cell death through activation of nuclear factor κB (NF-κB) and p53. Furthermore, we discovered that gemcitabine-induced loss of SIRT1 results in a nucleus-to-cytoplasm translocation of the sonic hedgehog (SHH) signaling activator GLI2, explaining the observed additional gemcitabine sensitivity in SHH-subtype ATRT. Treatment of ATRT xenograft-bearing mice with gemcitabine resulted in a >30% increase in median survival and yielded long-term survivors in two independent patient-derived xenograft models. These findings demonstrate that ATRTs are highly sensitive to gemcitabine treatment and may form part of a future multimodal treatment strategy for ATRTs.
Clinical outcomes and microenvironment profiling in relapsed/refractory multiple myeloma patients with extramedullary disease receiving anti‐<scp>BCMA CAR</scp> T‐cell‐based therapy
Authors: Yuekun Qi, Hujun Li, Kunming Qi, Feng Zhu, Hai Cheng, Wei Chen, Zhiling Yan, Depeng Li, Wei Sang, Xiaoming Fei, Weiying Gu, Yuqing Miao, Hongming Huang, Ying Wang, Tingting Qiu, Jianlin Qiao, Bin Pan, Ming Shi, Gang Wang, Zhenyu Li, Junnian Zheng, Kailin Xu, Jiang Cao
Journal: American Journal of Hematology (2024)

Abstract Relapsed/refractory multiple myeloma patients with extramedullary disease (EMD) have unfavorable prognosis and lack effective therapy. Chimeric antigen receptor (CAR) T‐cell activities in EMD have yet to be determined; how EMD‐specific microenvironment influences the clinical outcomes of CAR T‐cell therapy remains of great interest. In this prospective cohort study, patients with histologically confirmed extra‐osseous EMD were enrolled and treated with combined anti‐BCMA and anti‐CD19 CAR T‐cell therapy from May 2017 to September 2023. Thirty‐one patients were included in the study. Overall response occurred in 90.3% of medullary disease and 64.5% of EMD ( p = .031). Discrepancies in treatment response were noted between medullary and extramedullary diseases, with EMD exhibiting suboptimal and delayed response, as well as shortened response duration. With a median follow‐up of 25.3 months, the median progression‐free and overall survival were 5.0 and 9.7 months, respectively. Landmark analysis demonstrated that progression within 6 months post‐infusion is strongly associated with an increased risk of death (HR = 4.58; p = .029). Compared with non‐EMD patients, patients with EMD showed inferior survival outcomes. Unique CAR‐associated local toxicities at EMD were seen in 22.6% patients and correlated with the occurrence and severity of systemic cytokine release syndrome. To the cutoff date, 65% treated patients experienced EMD progression, primarily in the form of BCMA + progression. The pretherapy EMD immunosuppressive microenvironment, characterized by infiltration of exhausted CD8 + T cells, was associated with inferior clinical outcomes. CAR T cells have therapeutic activity in relapsed/refractory EMD, but the long‐term survival benefits may be limited. EMD‐specific microenvironment potentially impacts treatment. Further efforts are needed to extend EMD remission and improve long‐term outcomes.
Author Correction: Rare genetic coding variants associated with human longevity and protection against age-related diseases
Authors: Jhih-Rong Lin, Patrick Sin-Chan, Valerio Napolioni, Guillermo G. Torres, Joydeep Mitra, Quanwei Zhang, M. Reza Jabalameli, Zhen Wang, Nha Nguyen, Tina Gao, Matthias Laudes, Siegfried Görg, Andre Franke, Almut Nebel, Michael D. Greicius, Gil Atzmon, Kenny Ye, Vera Gorbunova, Warren C. Ladiges, Alan R. Shuldiner, Laura J. Niedernhofer, Paul D. Robbins, Sofiya Milman, Yousin Suh, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang
Journal: Nature Aging (2024)
Oh node: Extranodal nodular involvement of chronic lymphocytic leukemia in the colon
Authors: Michael Keith Alister Zimmerman, Lindsay Wilde
Journal: American Journal of Hematology (2024)

A 64-year-old male patient with a known diagnosis of chronic lymphocytic leukemia (CLL) was referred to the gastroenterology department for a follow-up colonoscopy. A previous routine colonoscopy 4 years prior found benign polyps in the colon, and the patient was recommended to have a repeat colonoscopy within 3 years. In the interim, the patient had no new gastrointestinal symptoms. However, he was diagnosed with CLL based on flow cytometry approximately 1 year after his first colonoscopy. At diagnosis, his CLL was Rai Stage 1, and he did not meet any criteria for treatment initiation. The repeat colonoscopy was notable for continuous diffuse nodularity without bleeding throughout the colon from the cecum to the rectum, with only relative sparing of the transverse colon as seen in Image 1. Multiple cold forceps biopsies were obtained of nodularities in the cecum/ascending colon, transverse colon, descending colon, and rectum. The biopsies were sent for histology to evaluate for suspected lymphoid aggregates but also to rule out polyposis syndrome. Histology showed submucosal atypical lymphoid infiltrate present as expansile nodules. The lymphocytes were small in size with dense chromatin and scant cytoplasm. Immunohistochemistry was diffusely positive for CD5, CD20, and CD23, and negative for BCL-1. Scattered reactive T cells were positive for CD3. P53 was wild-type. Ki-67 showed a variable proliferation rate of 10%–30%. All colonic biopsies showed similar findings consistent with the patient's known CLL. Despite these striking incidental clinical findings, the patient remains asymptomatic without cytopenias or constitutional symptoms. On exam he has stable supraclavicular lymphadenopathy with a palpable lymph node measuring approximately 3 cm in diameter that is non-tender and mobile. His white blood cell count is relatively stable, fluctuating between 18 and 43 × 109/L. Other routine lab work, including renal function and hepatic function, also all remain stable. No additional imaging studies have yet been performed. Therefore, the decision was made to continue clinically monitoring this patient without initiating treatment, as per standard of care.1 Extranodal involvement of CLL presenting as nodularity has been described in several organs, including the skin,2 kidneys,3 and cardiac valves.4 Gastrointestinal manifestations of CLL are rare. One report of extranodal involvement in the gastrointestinal tract described a patient who had a positive fecal test for occult blood prompting colonoscopy, which showed a normal-appearing colon but with CLL involvement on histology of biopsies.5 Another reported on a single 6 mm polyp in the ascending colon revealing intestinal infiltration of CLL on biopsy.6 To our knowledge, this is the first report of diffuse nodularity resulting from intestinal infiltration of CLL. The authors declare no conflicts of interest. Data sharing is not applicable to this article as no new data were created or analyzed in this study.
Increase 68Ga-FAPI Uptake in Urogenital Tuberculosis
Authors: Qiuming Yu, Qiang Xie, Xingxing Zhu, Xuemei Wang, Ming Ni
Journal: Clinical Nuclear Medicine (2024)

Urogenital tuberculosis is one of common sites of extrapulmonary tuberculosis. A 60-year-old man with an elevated prostate-specific antigen level underwent multiparametric MRI, which revealed abnormal signals in the prostate. However, the 68 Ga-PSMA PET/CT results were unrevealing. Subsequent 68 Ga-FAPI PET/CT imaging revealed intense radioactivity uptake in the prostate and mild radioactivity uptake in the left kidney, which was eventually proven due to tuberculosis.