tbuckley/cabot-search huggingface dataset:
Apolipoproteins Quantified Using Blood Volumetric Absorptive Microsampling and High-Throughput Mass Spectrometry for Risk Assessment in Ischemic Heart Disease
Authors: Paul Marano, Kelly Mouapi, Andy Kim, Mitra Mastali, Irene van den Broek, Danica Manalo, Qin Fu, Susan Cheng, Chrisandra Shufelt, Brennan Spiegel, C. Noel Bairey Merz, Jennifer E. Van Eyk
Journal: Circulation (2024)
A commentary on ‘Risk factors for incident venous thromboembolism in patients with renal tumor and inferior vena cava tumor thrombus: a retrospective case–control study’
Authors: Aimin Jiang, None Le Qu, Peng Luo, Linhui Wang
Journal: International Journal of Surgery (2024)

aDepartment of Urology, Changhai Hospital, Naval Medical University, Shanghai, China bDepartment of Urology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China cDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding Author. Address: Changhai Hospital, CHINA. E-mail address: [email protected] (L. Wang). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
“Diffuse Hot Pleura” in a Case of Recurrent Squamous Cell Carcinoma of the Foot
Authors: Abhiram G. Ashwathanaryana, Sarin Krishna, Arpan Chaturmohta, Parvathi Joshi, Shubham Asrani
Journal: Clinical Nuclear Medicine (2024)

Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer. Unlike basal cell carcinoma, regional lymph nodal metastases and subsequent distant site metastases are more common. Up to approximately 2% to 5% of cSCCs can result in distant metastases. Prognosis is dismal, and median survival is distinctly shortened in case of distant metastatic disease. Diffuse pleural metastases with distinctive overarching unilateral involvement are uncommon. Cutaneous SCC commonly metastasizes to lymph nodes, lungs, liver, bones, and skin. Diffuse unilateral pleural metastasis of cSCC of the foot is extremely rare. We report the case of a 54-year-old man with recurrent cSCC. On follow up restaging, 18 F-FDG PET/CT revealed diffuse nodular bipleural (visceral and parietal) hypermetabolic right pleural thickening, which was later biopsied and turned out to be diffuse pleural metastases from cSCC giving appearance of “hot pleura.”
Treatment Patterns and Survival Outcomes in Patients With Breast Cancer on Medicaid, Pre- and Post-Expansion
Authors: Siran M. Koroukian, Weichuan Dong, Jeffrey M. Albert, Uriel Kim, Kirsten Eom, Johnie Rose, Cynthia Owusu, Kristine M. Zanotti, Gregory Cooper, Jennifer Tsui
Journal: Journal of the National Comprehensive Cancer Network (2024)

The objective of this study was to evaluate the impact of Medicaid expansion on breast cancer treatment and survival among Medicaid-insured women in Ohio, accounting for the timing of enrollment in Medicaid relative to their cancer diagnosis and post-expansion heterogeneous Medicaid eligibility criteria, thus addressing important limitations in previous studies.
ROS-driven supramolecular nanoparticles exhibiting efficient drug delivery for chemo/Chemodynamic combination therapy for Cancer treatment
Authors: Huikun Chen, Chengyuan Xing, Hanqi Lei, Binyuan Yan, Hao Zhang, Tongyu Tong, Yupeng Guan, Yang Kang, Jun Pang
Journal: Journal of Controlled Release (2024)
Variation of NT-proBNP and High-Sensitivity Cardiac Troponin T Across Levels of Estimated Glomerular Filtration Rate: The SPRINT Trial
Authors: Nisha Bansal, Ronit Katz, Stephen Seliger, Christopher deFilippi, Nicholas Wettersten, James A. de Lemos, Robert Christenson, Anthony A. Killeen, Jarett D. Berry, Michael G. Shlipak, Joachim H. Ix
Journal: Circulation (2024)
Nurse-Led Individualized Follow-Up Versus Regular Physician-Led Visits After Early Breast Cancer (MyHealth): A Phase III Randomized, Controlled Trial
Authors: Lena Saltbæk, Pernille E. Bidstrup, Randi V. Karlsen, Beverley L. Høeg, Trine A. Horsboel, Federica Belmonte, Elisabeth A.W. Andersen, Vibeke Zoffmann, Anne S. Friberg, Mads N. Svendsen, Helle G. Christensen, Vesna Glavicic, Dorte L. Nielsen, Susanne O. Dalton, Christoffer Johansen
Journal: Journal of Clinical Oncology (2024)

Follow-up after breast cancer with regular visits has failed to detect recurrences, be cost-effective, and address patient needs.
Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatohepatitis
Authors: Chittampalli N. Yashaswini, Tianyue Qin, Dipankar Bhattacharya, Corina Amor, Scott Lowe, Amaia Lujambio, Shuang Wang, Scott L. Friedman
Journal: Journal of Hepatology (2024)
Unlocking potential: the role of the electron transport chain in immunometabolism
Authors: Alessia Zotta, Luke A.J. O’Neill, Maureen Yin
Journal: Trends in Immunology (2024)

The electron transport chain (ETC) couples electron transfer with proton pumping to generate ATP and it also regulates particular innate and adaptive immune cell function. While NLRP3 inflammasome activation was initially linked to reactive oxygen species (ROS) produced from Complexes I and III, recent research suggests that an intact ETC fueling ATP is needed. Complex II may be responsible for Th1 cell proliferation and in some cases, effector cytokine production. Complex III is required for regulatory T (Treg) cell function, while oxidative phosphorylation (OXPHOS) and Complexes I, IV, and V sustain proliferation and antibody production in B lymphocytes, with OXPHOS also being required for B regulatory (Breg) cell function. Despite challenges, the ETC shows therapeutic targeting potential for immune-related diseases and in immuno-oncology.
The International Association for the Study of Lung Cancer (IASLC) Staging Project for Lung Cancer: Recommendation to Introduce Spread Through Air Spaces as a Histologic Descriptor in the Ninth Edition of the TNM Classification of Lung Cancer. Analysis of 4061 Pathologic Stage I NSCLC
Authors: William D. Travis, Megan Eisele, Katherine K. Nishimura, Rania G. Aly, Pietro Bertoglio, Teh-Ying Chou, Frank C. Detterbeck, Jessica Donnington, Wentao Fang, Philippe Joubert, Kemp Kernstine, Young Tae Kim, Yolande Lievens, Hui Liu, Gustavo Lyons, Mari Mino-Kenudson, Andrew G. Nicholson, Mauro Papotti, Ramon Rami-Porta, Valerie Rusch, Shuji Sakai, Paula Ugalde, Paul Van Schil, Chi-Fu Jeffrey Yang, Vanessa J. Cilento, Masaya Yotsukura, Hisao Asamura
Journal: Journal of Thoracic Oncology (2024)
Improved Microcirculation with Pulsatile Venoarterial Extracorporeal Membrane Oxygenation: An Ovine Model of Cardiogenic Shock
Authors: Silver Heinsar, Kei Sato, Nchafatso Obonyo, Samia M. Farah, Mahe Bouquet, Margaret R. Passmore, Keibun Liu, Shinichi Ijunin, Carmen Ainola, Gianluigi Li Bassi, Jacky Y. Suen, John F. Fraser
Journal: American Journal of Respiratory and Critical Care Medicine (2024)
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis
Authors: Jinbo Hu, Wen Liu, Yi Zou, Chenyang Jiao, Jiazhen Zhu, Qiang Xu, Jianjun Zou, Yang Sun, Wenjie Guo
Journal: Acta Pharmaceutica Sinica B (2024)

Src homology 2 domain-containing tyrosine phosphatase 2 (SHP2) is an essential tyrosine phosphatase that is pivotal in regulating various cellular signaling pathways such as cell growth, differentiation, and survival. The activation of SHP2 has been shown to have a therapeutic effect in colitis and Parkinson's disease. Thus, the identification of SHP2 activators and a complete understanding of their mechanisms is required. We used a two-step screening assay to determine a novel allosteric activator of SHP2 that stabilizes it in an open conformation. Oleanolic acid was identified as a suitable candidate. By binding to R362, K364, and K366 in the active center of the PTP domain, oleanolic acid maintained the active open state of SHP2, which facilitated the binding between SHP2 and its substrate. This oleanolic acid-activated SHP2 hindered Th17 differentiation by disturbing the interaction between STAT3 and IL-6Rα and inhibiting the activation of STAT3. Furthermore, via the activation of SHP2 and subsequent attenuation of the STAT3–Th17 axis, oleanolic acid effectively mitigated colitis in mice. This protective effect was abrogated by SHP2 knockout or administration of the SHP2 inhibitor SHP099. These findings underscore the potential of oleanolic acid as a promising therapeutic agent for treating inflammatory bowel diseases.
Sacubitril/Valsartan in Patients Hospitalized With Decompensated Heart Failure
Authors: David A. Morrow, Eric J. Velazquez, Akshay S. Desai, Adam D. DeVore, Serge Lepage, Jeong-Gun Park, Kavita Sharma, Scott D. Solomon, Randall C. Starling, Jonathan H. Ward, Kristin M. Williamson, Shelley Zieroth, Adrian F. Hernandez, Robert J. Mentz, Eugene Braunwald
Journal: Journal of the American College of Cardiology (2024)

The efficacy and safety of sacubitril/valsartan in patients hospitalized with heart failure (HF) across the spectrum of left ventricular ejection fraction (EF) has not been described. Data from randomized trials of sacubitril/valsartan in HF patients with EF ≤40% (PIONEER-HF [Comparison of Sacubitril/Valsartan Versus Enalapril on Effect of NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode] trial) and >40% (PARAGLIDE-HF [Prospective comparison of ARNI with ARB Given following stabiLization In DEcompensated HFpEF] trial) following recent worsening heart failure (WHF) were pooled to examine treatment effect across the EF spectrum. The PIONEER-HF and PARAGLIDE-HF trials were double-blind, randomized trials of sacubitril/valsartan vs control therapy (enalapril or valsartan, respectively). All participants in the PIONEER-HF trial and 69.5% in the PARAGLIDE-HF trial were enrolled during hospitalization for HF after stabilization. The remainder in the PARAGLIDE-HF trial were enrolled ≤30 days after a WHF event. The primary endpoint of both trials was time-averaged proportional change in N-terminal pro–B-type natriuretic peptide (NT-proBNP) from baseline through weeks 4 and 8. Adjudicated clinical endpoints were analyzed through the end of follow-up, adjusting for trial. The pooled analysis included 1,347 patients (881 from PIONEER-HF, 466 from PARAGLIDE-HF). Baseline characteristics included median age 66 years, 36% women, 31% Black, 34% de novo HF, and median EF 30%. The reduction in NT-proBNP was 24% greater with sacubitril/valsartan vs control therapy (n = 1,130; ratio of change = 0.76; 95% CI: 0.69-0.83; P < 0.0001). Cardiovascular death or hospitalization for HF was reduced by 30% with sacubitril/valsartan vs control therapy (HR: 0.70; 95% CI: 0.54-0.91; P = 0.0077). This effect was consistent across the spectrum of EF ≤60%. Sacubitril/valsartan increased symptomatic hypotension (risk ratio: 1.35; 95% CI: 1.05-1.72). In patients stabilized after WHF, sacubitril/valsartan led to a greater reduction in plasma NT-proBNP and improved clinical outcome compared with control therapy, in particular across the spectrum of EF ≤60%. (Comparison of Sacubitril/Valsartan Versus Enalapril on Effect of NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode [PIONEER-HF]; NCT02554890; Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event [HFpEF Decompensation] Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation [PARAGLIDE-HF]; NCT03988634)
Four-week inhibition of the renin–angiotensin system in spontaneously hypertensive rats results in persistently lower blood pressure with reduced kidney renin and changes in expression of relevant gene networks
Authors: Sean G Byars, Priscilla R Prestes, Varaporn Suphapimol, Fumihiko Takeuchi, Nathan De Vries, Michelle C Maier, Mariana Melo, David Balding, Nilesh Samani, Andrew M Allen, Norihiro Kato, Jennifer L Wilkinson-Berka, Fadi Charchar, Stephen B Harrap
Journal: Cardiovascular Research (2024)

Prevention of human hypertension is an important challenge and has been achieved in experimental models. Brief treatment with renin-angiotensin system (RAS) inhibitors permanently reduces the genetic hypertension of the spontaneously hypertensive rat (SHR). The kidney is involved in this fascinating phenomenon, but relevant changes in gene expression are unknown.
Cold endoscopic mucosal resection versus cold snare polypectomy for colorectal lesions: a systematic review and meta-analysis of randomized controlled trials
Authors: Paula Arruda do Espirito Santo, Gilmara Coelho Meine, Stefano Baraldo, Eduardo Cerchi Barbosa
Journal: Endoscopy (2024)

Cold resection of colorectal lesions is widely performed because of its safety and effectiveness; however, it remains uncertain whether adding submucosal injection could improve the efficacy and safety. We aimed to compare cold endoscopic mucosal resection (C-EMR) versus cold snare polypectomy (CSP) for colorectal lesions.
Cigarette Smoking and E-cigarette Use Induce Shared DNA Methylation Changes Linked to Carcinogenesis
Authors: Chiara Herzog, Allison Jones, Iona Evans, Janhavi R. Raut, Michal Zikan, David Cibula, Andrew Wong, Hermann Brenner, Rebecca C. Richmond, Martin Widschwendter
Journal: Cancer Research (2024)

Abstract Tobacco use is a major modifiable risk factor for adverse health outcomes, including cancer, and elicits profound epigenetic changes thought to be associated with long-term cancer risk. While electronic cigarettes (e-cigarettes) have been advocated as harm reduction alternatives to tobacco products, recent studies have revealed potential detrimental effects, highlighting the urgent need for further research into the molecular and health impacts of e-cigarettes. Here, we applied computational deconvolution methods to dissect the cell- and tissue-specific epigenetic effects of tobacco or e-cigarette use on DNA methylation (DNAme) in over 3,500 buccal/saliva, cervical, or blood samples, spanning epithelial and immune cells at directly and indirectly exposed sites. The 535 identified smoking-related DNAme loci [cytosine-phosphate-guanine sites (CpG)] clustered into four functional groups, including detoxification or growth signaling, based on cell type and anatomic site. Loci hypermethylated in buccal epithelial cells of smokers associated with NOTCH1/RUNX3/growth factor receptor signaling also exhibited elevated methylation in cancer tissue and progressing lung carcinoma in situ lesions, and hypermethylation of these sites predicted lung cancer development in buccal samples collected from smokers up to 22 years prior to diagnosis, suggesting a potential role in driving carcinogenesis. Alarmingly, these CpGs were also hypermethylated in e-cigarette users with a limited smoking history. This study sheds light on the cell type–specific changes to the epigenetic landscape induced by smoking-related products. Significance: The use of both cigarettes and e-cigarettes elicits cell- and exposure-specific epigenetic effects that are predictive of carcinogenesis, suggesting caution when broadly recommending e-cigarettes as aids for smoking cessation.
AI-assisted HIV case finding in Ukraine
Authors: Ed Holt
Journal: The Lancet Microbe (2024)

When Russia launched its full-scale invasion of Ukraine in February, 2022, there were an estimated 245 000 Ukranians living with HIV and it was feared the fighting would lead to an increase in HIV incidence as access to treatment and case finding would be heavily affected. 2 years later, it seems that this has not come to pass. According to latest WHO figures, the Ukrainian Ministry of Health reported 9769 new HIV cases between January and October, 2023, essential HIV services has remained operational, and HIV data continues to be reported to global surveillance initiatives.
Impact of climate change and natural disasters on fungal infections
Authors: Danila Seidel, Sebastian Wurster, Jeffrey D Jenks, Hatim Sati, Jean-Pierre Gangneux, Matthias Egger, Ana Alastruey-Izquierdo, Nathan P Ford, Anuradha Chowdhary, Rosanne Sprute, Oliver Cornely, George R Thompson, Martin Hoenigl, Dimitrios P Kontoyiannis
Journal: The Lancet Microbe (2024)

The effects of climate change and natural disasters on fungal pathogens and the risks for fungal diseases remain incompletely understood. In this literature review, we examined how fungi are adapting to an increase in the Earth's temperature and are becoming more thermotolerant, which is enhancing fungal fitness and virulence. Climate change is creating conditions conducive to the emergence of new fungal pathogens and is priming fungi to adapt to previously inhospitable environments, such as polluted habitats and urban areas, leading to the geographical spread of some fungi to traditionally non-endemic areas. Climate change is also contributing to increases in the frequency and severity of natural disasters, which can trigger outbreaks of fungal diseases and increase the spread of fungal pathogens. The populations mostly affected are the socially vulnerable. More awareness, research, funding, and policies on the part of key stakeholders are needed to mitigate the effects of climate change and disaster-related fungal diseases.
Staphylococcus aureus colonisation and strategies for decolonisation
Authors: Pipat Piewngam, Michael Otto
Journal: The Lancet Microbe (2024)

Staphylococcus aureus is a leading cause of death by infectious diseases worldwide. Treatment of S aureus infections is difficult due to widespread antibiotic resistance, necessitating alternative approaches and measures for prevention of infection. Because S aureus infections commonly arise from asymptomatic colonisation, decolonisation is considered a key approach for their prevention. Current decolonisation procedures include antibiotic-based and antiseptic-based eradication of S aureus from the nose and skin. However, despite the widespread implementation and partial success of such measures, S aureus infection rates remain worrisome, and resistance to decolonisation agents is on the rise. In this Review we outline the epidemiology and mechanisms of S aureus colonisation, describe how colonisation underlies infection, and discuss current and novel approaches for S aureus decolonisation, with a focus on the latest findings on probiotic strategies and the intestinal S aureus colonisation site.
A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing
Authors: Yumeng Wang, Xinghong Zhao, Xingjian Zhou, Juqin Dai, Xiaowen Hu, Yinzi Piao, Guangyue Zu, Jian Xiao, Keqing Shi, Yong Liu, Yuanfeng Li, Linqi Shi
Journal: Journal of Controlled Release (2024)
An injectable and coagulation-independent Tetra-PEG hydrogel bioadhesive for post-extraction hemostasis and alveolar bone regeneration
Authors: Gang He, Yiwen Xian, Huajun Lin, Chengcheng Yu, Luyuan Chen, Zhihui Chen, Yonglong Hong, Chong Zhang, Decheng Wu
Journal: Bioactive Materials (2024)

Effective control of post-extraction hemorrhage and alveolar bone resorption is critical for successful extraction socket treatment, which remains an unmet clinical challenge. Herein, an injectable Tetra-PEG hydrogel that possesses rapid gelation, firm tissue adhesion, high mechanical strength, suitable degradability, and excellent biocompatibility is developed as a sutureless and coagulation-independent bioadhesive for the management of extraction sockets. Our results demonstrate that the rapid and robust adhesive sealing of the extraction socket by the Tetra-PEG hydrogel can provide reliable protection for the underlying wound and stabilize blood clots to facilitate tissue healing.
Zinc hybrid polyester barrier membrane accelerates guided tissue regeneration
Authors: Qiao Zhang, Chaoqian Lou, Hang Li, Yanyan Li, Hongjie Zhang, Zimeng Li, Ganggang Qi, Xia Cai, Qiaojie Luo, Lijie Fan, Xiaojun Li, Weiwei Lao, Weipu Zhu, Xiaodong Li
Journal: Journal of Controlled Release (2024)
Active targeting tumor therapy using host-guest drug delivery system based on biotin functionalized azocalix[4]arene
Authors: Meng-Meng Chen, Xingchen Tang, Juan-Juan Li, Fang-Yuan Chen, Ze-Tao Jiang, Rong Fu, Hua-Bin Li, Xin-Yue Hu, Wen-Chao Geng, Dong-Sheng Guo
Journal: Journal of Controlled Release (2024)
Liposome-integrated hydrogel hybrids: Promising platforms for cancer therapy and tissue regeneration
Authors: Mehdi Sanati, Saber Amin Yavari
Journal: Journal of Controlled Release (2024)

Drug delivery platforms have gracefully emerged as an indispensable component of novel cancer chemotherapy, bestowing targeted drug distribution, elevating therapeutic effects, and reducing the burden of unwanted side effects. In this context, hybrid delivery systems artfully harnessing the virtues of liposomes and hydrogels bring remarkable benefits, especially for localized cancer therapy, including intensified stability, excellent amenability to hydrophobic and hydrophilic medications, controlled liberation behavior, and appropriate mucoadhesion to mucopenetration shift. Moreover, three-dimensional biocompatible liposome-integrated hydrogel networks have attracted unprecedented interest in tissue regeneration, given their tunable architecture and physicochemical properties, as well as enhanced mechanical support. This review elucidates and presents cutting-edge developments in recruiting liposome-integrated hydrogel systems for cancer treatment and tissue regeneration.
A quantitative MRI-based approach to estimate the permeation and retention of nanomedicines in tumors
Authors: Alireza Nomani, Siavash Yousefi, Davit Sargsyan, Arash Hatefi
Journal: Journal of Controlled Release (2024)

Despite the potential of the enhanced permeability and retention (EPR) effect in tumor passive targeting, many nanotherapeutics have failed to produce meaningful clinical outcomes due to the variable and challenging nature of the tumor microenvironment (TME) and EPR effect. This EPR variability across tumors and inconsistent translation of nanomedicines from preclinical to clinical settings necessitates a reliable method to assess its presence in individual tumors. This study aimed to develop a reliable and non-invasive approach to estimate the EPR effect in tumors using a clinically compatible quantitative magnetic resonance imaging (qMRI) technique combined with a nano-sized MRI contrast agent. A quantitative MR imaging was developed using a dynamic contrast-enhanced (DCE) MRI protocol. Then, the permeability and retention of the nano-sized MRI contrast agent were evaluated in three different ovarian xenograft tumor models. Results showed significant differences in EPR effects among the tumor models, with tumor growth influencing the calculated parameters of permeability (K
Efficacy of mitral valve repair in combination with coronary revascularization for moderate ischaemic mitral regurgitation: a systematic review and meta-analysis of randomized controlled trials
Authors: Xin Li, Biao Hou, Shuwen Hou, Wenjian Jiang, Yuyong Liu, Hongjia Zhang
Journal: International Journal of Surgery (2024)

The efficacy of mitral valve repair (MVR) in combination with coronary artery bypass grafting (CABG) for moderate ischaemic mitral regurgitation (IMR) remains unclear. To evaluate whether MVR + CABG is superior to CABG alone, the authors conducted a systematic review and meta-analysis of existing randomized controlled trials (RCTs).