tbuckley/cabot-search huggingface dataset:
Continuous three-dimensional transesophageal echocardiography and deep learning for perioperative monitoring of left ventricular longitudinal function
Authors: Jinyang Yu, Anders Austlid Taskén, Erik Andreas Rye Berg, Tomas Dybos Tannvik, Katrine Hordnes Slagsvold, Idar Kirkeby-Garstad, Bjørnar Grenne, Gabriel Kiss, Svend Aakhus
Journal:  (2025)

Abstract Aims Continuous monitoring of left ventricular (LV) function may improve cardiopulmonary management. Therefore, we have developed 3D autoMAPSE, a novel method that combines 3D transesophageal echocardiography and deep learning to automatically measure mitral annular plane systolic excursion (MAPSE). We hypothesized that 3D autoMAPSE could provide continuous monitoring of LV function in perioperative patients. Methods This prospective observational study included 50 adult intensive care patients after cardiac surgery. Single-beat full-volume 3D recordings were obtained every five minutes over a 120-minute period using a hands-free method that simulated continuous monitoring with transesophageal echocardiography. Precision and agreement with manual MAPSE were determined by a test-retest study design during hemodynamic stability. Results Continuous monitoring by 3D autoMAPSE had excellent feasibility (99%). It analyzed 10 cycles instantaneously (55 ± 15 seconds) with high precision (least significant change 1.6 mm). 3D autoMAPSE had adequate agreement with manual MAPSE (bias -1.4 mm, limits of agreement -4.0 to 1.2 mm). Continuous 3D autoMAPSE was associated with both N-terminal pro B-type natriuretic peptide (rho = -0.37, P = 0.008) and high-sensitivity troponin-T (rho = -0.28, P = 0.047). This association was slightly stronger than for LV ejection fraction or any other single echocardiographic measurement. Conclusion 3D autoMAPSE provided continuous monitoring of LV function in perioperative patients by obtaining highly feasible and precise measurements that agree with manual echocardiography and postoperative biomarkers. Thus, continuous 3D autoMAPSE may be an attractive complement to hemodynamic monitoring that can aid cardiopulmonary management.
Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes
Authors: Mechthild Lütge, Lisa Kurz, Yves Stanossek, Samuel Meili, Hung-Wei Cheng, Angelina De Martin, Joshua Brandstadter, Ivan Maillard, Mark D. Robinson, Sandro J. Stoeckli, Natalia B. Pikor, Lucas Onder, Burkhard Ludewig
Journal: Science Immunology (2025)

Lymph nodes play a key role in maintaining fluid balance in homeostatic and inflamed tissues and provide fibroblastic niche environments for optimal immune cell positioning and interaction. Here, we used single-cell and spatial transcriptomic analyses in combination with high-resolution imaging to molecularly define and functionally characterize niche-forming cells that control inflammation-driven remodeling in human lymph nodes. Fibroblastic reticular cells responded to inflammatory perturbation with activation and expansion of poised niche environments. Inflammation-induced adaptation of lymph node infrastructure and topography included the expansion of peptidase inhibitor 16 (PI16)–expressing reticular cell (PI16 + RC) networks that enwrap the perivenular conduit system. Interactome analyses indicated that macrophage-derived oncostatin M directs PI16 + RC activation in inflamed lymph nodes and thereby promotes immune cell aggregation in the perivenular space. In conclusion, these data demonstrate that the inflammatory remodeling of human lymph nodes results in the formation of reactive myeloid cell niches by PI16 + RCs.
The DBS proteome identifies a subclinical IFN signature in neonates with type I interferonopathy
Authors: Hiroshi Nihira, Daisuke Nakajima, Kazushi Izawa, Yusuke Kawashima, Hirofumi Shibata, Ryo Konno, Motoko Higashiguchi, Takayuki Miyamoto, Masahiko Nishitani-Isa, Eitaro Hiejima, Yoshitaka Honda, Tadashi Matsubayashi, Takashi Ishihara, Masato Yashiro, Naomi Iwata, Yoko Ohwada, Seiichi Tomotaki, Masahiko Kawai, Kosaku Murakami, Hidenori Ohnishi, Masataka Ishimura, Satoshi Okada, Motoi Yamashita, Tomohiro Morio, Akihiro Hoshino, Hirokazu Kanegane, Kohsuke Imai, Yasuko Nakamura, Shigeaki Nonoyama, Toru Uchiyama, Masafumi Onodera, Takashi Ishikawa, Toshinao Kawai, Junko Takita, Ryuta Nishikomori, Osamu Ohara, Takahiro Yasumi
Journal: Journal of Allergy and Clinical Immunology (2025)
Penetrative Biomimetic Nanovehicle Boosts Immunotherapy in Triple-Negative Breast Cancer via SOS1 Blockade
Authors: Jiaxin Zhang, Peng Xian, Chao Wang, Xier Pan, Yaoyao Du, Yunrong Nan, Qing Pu, Linghui Zou, Donovan Green, Shuting Ni, Kaili Hu
Journal: Asian Journal of Pharmaceutical Sciences (2025)
Long-term effect of anifrolumab on patient-reported outcomes in systemic lupus erythematosus (TULIP-LTE): a randomised, placebo-controlled, phase 3 long-term extension trial
Authors: Vibeke Strand, Kenneth C Kalunian, Kai Wai Lee, Caroline Seo, Gabriel Abreu, Raj Tummala, Hussein Al-Mossawi, Elizabeth A Duncan, Catharina Lindholm
Journal: The Lancet Rheumatology (2025)
Low-dose moderate hypofractionated radiotherapy for indolent non-Hodgkin lymphoma: a multicentre, single-arm, phase 2 trial
Authors: Xin-Yue Wang, Xi-Mei Zhang, Liang Wang, Lin-Rui Gao, Ke Chen, Xiao-Li Feng, Wei Rao, Rong Zheng, Yun-Peng Wu, Yong-Wen Song, Hui Fang, Bo Chen, Jing Jin, Yue-Ping Liu, Hao Jing, Yuan Tang, Wen-Wen Zhang, Yi-Rui Zhai, Ning-Ning Lu, Ning Li, Chang-Fa Xia, Shu-Lian Wang, Xin Liu, Ye-Xiong Li, Shu-Nan Qi
Journal: The Lancet Haematology (2025)
Perioperative Safety and Efficacy of Efgartigimod for Thymoma associated Myasthenia Gravis: A Prospective, Multicenter, Phase II Clinical Trial
Authors: Shuai Wang, Min Zhu, Jihong Dong, Yong Zhang, Sushan Luo, Jiahao Jiang, Zhaozhao Cheng, Zhijun Li, Wenping Yang, Yue Yu, Zhengcheng Liu, Jiang Fan, Xiangnan Xu, Peipei Liu, Zhouao Zhang, Fang Can, Fei Liang, Xifei Jiang, Lijie Tan, Jianyong Ding
Journal: Journal of Thoracic Oncology (2025)
Neuromodulatory signaling contributing to the encoding of aversion
Authors: Cheng-Hsi Wu, Léa Camelot, Salvatore Lecca, Manuel Mameli
Journal: Trends in Neurosciences (2025)

The appropriate and rapid encoding of stimuli bearing a negative valence enables behaviors that are essential for survival. Recent advances in neuroscience using rodents as a model system highlight the relevance of cell type-specific neuronal activities in diverse brain networks for the encoding of aversion, as well as their importance for subsequent behavioral strategies. Within these networks, neuromodulators influence cell excitability, adjust fast synaptic neurotransmission, and affect plasticity, ultimately modulating behaviors. In this review we first discuss contemporary findings leveraging the use of cutting-edge neurotechnologies to define aversion-related neural circuits. The spatial and temporal dynamics of the release of neuromodulators and neuropeptides upon exposure to aversive stimuli are described within defined brain circuits. Together, these mechanistic insights update the present neural framework through which aversion drives motivated behaviors.
Characterization and Clinical Implications of p53 Dysfunction in Patients With Myelodysplastic Syndromes
Authors: Matteo Zampini, Elena Riva, Luca Lanino, Elisabetta Sauta, Rita Antunes Dos Reis, Rosa Maria Andres Ejarque, Giulia Maggioni, Alberto Termanini, Alessandra Merlotti, Alessia Campagna, Lorenzo Dall’Olio, Austin Kulasekararaj, Michela Calvi, Clara Di Vito, Arturo Bonometti, Daoud Rahal, Giorgio Croci, Emanuela Boveri, Umberto Gianelli, Maurilio Ponzoni, Rossella Caselli, Serena Albertazzi, Gabriele Todisco, Marta Ubezio, Laura Crisafulli, Alessandro Frigo, Enrico Lugli, Ettore Mosca, Pamela Acha, Serena Ghisletti, Francesco Nicassio, Armando Santoro, Maria Diez-Campelo, Francesc Solé, Lionel Ades, Uwe Platzbecker, Valeria Santini, Pierre Fenaux, Torsten Haferlach, David Sallman, Guillermo Garcia-Manero, Domenico Mavilio, Daniel Remondini, Gastone Castellani, Saverio D'Amico, Amer M. Zeidan, Rami Komrokji, Shahram Kordasti, Francesca Ficara, Matteo Giovanni Della Porta, Antonio Russo, Erica Travaglino, Mattia Delleani, Gianluca Asti, Denise Ventura, Cristina A. Tentori, Alessandro Buizza, Matteo Brindisi, Nicole Pinocchio, Francesco Pesce
Journal: Journal of Clinical Oncology (2025)

PURPOSE Tumor Protein 53 (p53) expressed from gene TP53 is a seminal tumor suppressor. We aimed to characterize mutational and nonmutational mechanisms of p53 dysfunction in myelodysplastic syndromes (MDS) and to investigate their clinical effect. PATIENTS AND METHODS We analyzed a cohort of 6,204 patients with MDS and subsets of patients with available information on RNA sequencing of tumor cells (n = 109), high-dimensional phenotype of immune cells (n = 77), and multiomics analysis (RNA sequencing and proteomics) on single cells (n = 15). An independent validation was performed on 914 patients. RESULTS Biallelic TP53 inactivation was a powerful driver of disease progression and identified high-risk patients, regardless of variant allele frequency. Monoallelic and biallelic inactivation represent disease stages occurring as a multihit process in MDS with TP53 mutations, thus potentially refining the optimal timing of therapeutic interventions in these patients. We identified a subset of MDS (5%) characterized by TP53 wild-type and hyperexpression of abnormal p53 protein in bone marrow progenitors that exhibit dismal outcome. These patients presented upstream p53 signaling aberrations in Pi3K cascade; RAS, WNT, and NF-KB pathways; and MDM2 gene amplification, together with a downstream dysregulation of p53 targets. MDS with p53 dysfunction displayed a distinct immune dysregulation involving myeloid-derived inflammation and impaired antigen presentation, which may be a driver of their poor prognosis and provide the groundwork for innovative immunotherapies. CONCLUSION The identification of nonmutational p53 dysfunction in MDS may lay the foundation for a mechanistic classification of myeloid neoplasms, moving beyond a purely molecular stratification. The recognition of patients with p53 dysfunction is relevant to provide correct disease-risk assessment and interventions, as well as to refine the design of clinical trials
Re: Thomas van Doeveren, Sebastiaan Remmers, Egbert R. Boevé, et al. Intravesical Instillation of Chemotherapy Before Radical Surgery for Upper Urinary Tract Urothelial Carcinoma: The REBACARE Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2024.12.006
Authors: Kamil Malshy, Jathin Bandari, Edward M Messing
Journal: European Urology (2025)
Updated Prostate Cancer Risk Groups by Prostate-specific Membrane Antigen Positron Emission Tomography Prostate Cancer Molecular Imaging Standardized Evaluation (PPP2): Results from an International Multicentre Registry Study
Authors: Madeleine J Karpinski, Kambiz Rahbar, Martin Bögemann, Laya Rahbar Nikoukar, Michael Schäfers, Sebastian Hoberück, Matthias Miederer, Tobias Hölscher, Sazan Rasul, Marcin Miszczyk, Francesco Lanfranchi, Matteo Bauckneht, Christian H Pfob, Felix Kind, Karolien Goffin, Anika Hüsing, Claudia Kesch, Ken Herrmann, Martin Stuschke, Andrei Gafita, Johannes Hüsing, Jeremie Calais, Michael S Hofman, Thomas A Hope, Jonathan Miksch, Timo F W Soeterik, Andrea Di Giorgio, Andrea Farolfi, Anders Bjartell, Elin Trägårdh, Lena M Unterrainer, Adrien Holzgreve, Gabriel T Sheikh, Isabel Rauscher, Matthias Eiber, Boris A Hadaschik, Wolfgang P Fendler
Journal: European Urology (2025)

We established prognostic nomograms incorporating prostate-specific membrane antigen (PSMA) positron emission tomography (PET) parameters standardised by Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE; PPP1). Here, we develop an updated PPP2 risk score from a large international multicentre registry study. We included 6128 prostate cancer patients who underwent PSMA-PET at 20 hospitals in Europe, USA, and Australia between 2013 and 2022. Investigator sites were split 2:1 into the development (4044 patients) and validation (2084 patients) cohorts. We created nomograms of version 2 (PPP2) based on Cox regression models with the least absolute shrinkage and selection operator penalty for overall survival (development cohort). Performance of both nomograms was measured using Harrell's C-index and calibration plots and a head-to-head comparison with the National Comprehensive Cancer Network (NCCN) risk score by receiver operating characteristic curves (validation cohort). Predictors were distant metastases (extrapelvic nodal metastases [M1a], bone metastases [M1b], and visceral metastases [M1c]), PSMA expression score, and total lesion count (visual PPP2) or total tumour volume (quantitative PPP2). C-indices (95% confidence interval) in the validation cohort were 0.80 (0.78-0.82; visual) and 0.80 (0.79-0.82; quantitative), respectively. Accuracy of both the PPP2 nomograms was superior to the NCCN risk score (n = 1034, area under the curve 0.84 vs 0.76; p < 0.001). The retrospective design represents a limitation of the study. PPP nomograms were improved in an international multicentre study to predict accurately the 3- and 5-yr overall survival probabilities of prostate cancer. PPP2 yielded superior accuracy to the NCCN risk score. A free software tool has been created for PROMISE and PPP2 assessments (promise-pet.org).
TP53 and CDKN2A alterations define a poor prognostic subgroup in patients with nodal T follicular helper cell lymphoma
Authors: Yuta Ito, Joji Shimono, Keisuke Kawamoto, Kanako C Hatanaka, Yasunori Kogure, Mariko Tabata, Yuki Saito, Kota Mizuno, Sara Horie, Yosuke Mizukami, Junji Koya, Koichi Murakami, Takanori Teshima, Yutaka Hatanaka, Kenichi Chiba, Ai Okada, Yuichi Shiraishi, Hiroaki Miyoshi, Yoshihiro Matsuno, Koichi Ohshima, Keisuke Kataoka, Masao Nakagawa
Journal: Leukemia (2025)
Application of new approach methodologies for nonclinical safety assessment of drug candidates
Authors: Mario Beilmann, Karissa Adkins, Harrie C M Boonen, Philip Hewitt, Wenyue Hu, Robert Mader, Susanne Moore, Payal Rana, Thomas Steger-Hartmann, Remi Villenave, Terry van Vleet
Journal: Nature Reviews Drug Discovery (2025)
Evaluation of the Responsiveness of Investigator Global Assessment Score (KP-IGA) and Composite Area Index (KPAI) for Keratosis Pilaris
Authors: Pooi C Wong, Hossein Akbarialiabad, Madeline A Wang, Tangqi J Ng, Anna Wilson, Boaz Shulruf, Dédée F Murrell
Journal: British Journal of Dermatology (2025)

The Keratosis Pilaris Investigator Global Assessment (KP-IGA) and its composite area index (KPAI) were evaluated for responsiveness and Minimal Clinically Important Differences (MCID) in 16 patients undergoing laser treatment. KPAI demonstrated greater responsiveness than KP-IGA, with MCIDs of 1 and 5, respectively, and severity cut-offs of 10 for moderate and 34 for mild disease. These findings validate KP-IGA and KPAI as reliable scoring tools for KP clinical trials.
Outcomes of acute myeloid leukemia with KMT2A (MLL) rearrangement: a multicenter study of TROPHY group
Authors: Ruoxuan Zhang, Huihong Huang, Yi Zhang, Yi Xia, Jiayu Huang, Chuanhe Jiang, Luxiang Wang, Haiyang Lu, Zengkai Pan, Gaoxiang Wang, Yang Yang, Yilei Ma, Xiaodong Mo, Wei Shi, Xiaoxia Hu, Yang Cao
Journal: Blood Cancer Journal (2025)
Cultural Considerations in Assessing Dietary Intake in Racially, Ethnically, or Socioeconomically Diverse Populations
Authors: Katherine L. Tucker, Sabrina E. Noel
Journal: Annual Review of Nutrition (2025)

The United States is experiencing rapid growth of racial and ethnic minority aging populations, with implications for health disparities research, as many of these groups experience excess prevalence of chronic diseases. The reasons for health disparities are multifactorial, including social determinants of health, with nutrition playing a critical role. The current inadequacy of dietary assessment methods limits this research. Evidence from food frequency questionnaires with multiethnic studies consistently shows lower validity among minority adults, even with some adaptation, relative to non-Hispanic White adults. This is likely to introduce not only error but also bias in estimates. In addition to adding foods, culturally specific recipes and portion sizes must be considered. Among those with low education, careful data collection with trained interviewers is essential. Important barriers to change include limited access to healthy foods, cultural preferences that influence dietary choices, and limited nutrition knowledge. Rediscovering traditional foodways may be an effective tool.
New Insights into Folate–Vitamin B12 Interactions
Authors: Luisa F. Castillo, Caitlyn M. Pelletier, Katarina E. Heyden, Martha S. Field
Journal: Annual Review of Nutrition (2025)

Folate and vitamin B 12 (B12) are essential cofactors in folate-mediated one-carbon metabolism (FOCM). FOCM includes a series of methyl transfer reactions for methionine regeneration and de novo synthesis of nucleotides, including thymidylate. Deficiency in either folate or B12 can result in negative health outcomes including megaloblastic anemia, with additional neurocognitive impairments observed as a result of B12 deficiency. While folate deficiency is not common in the United States due to mandatory folic acid fortification, B12 deficiency is observed more frequently, particularly in certain subpopulations such as vegetarians/vegans and older adults. Fortification of the food supply with folic acid has been effective to increase folate status and reduce the incidence of birth defects. However, consumption of fortified foods and use of dietary supplements containing folic acid have led to an increase in the proportion of individuals exceeding the tolerable upper intake level of folic acid. Although the interaction between folate and B12 has been appreciated for decades in relation to megaloblastic anemia, it has been recently proposed that elevated serum folate may worsen neurocognitive effects and other metabolic impairments (altered glucose homeostasis, type 2 diabetes in offspring) associated with B12 deficiency. This review highlights molecular mechanisms that may explain the biology underlying these associations with a focus on findings from studies in model systems.
Small language models learn enhanced reasoning skills from medical textbooks
Authors: Hyunjae Kim, Hyeon Hwang, Jiwoo Lee, Sihyeon Park, Dain Kim, Taewhoo Lee, Chanwoong Yoon, Jiwoong Sohn, Jungwoo Park, Olga Reykhart, Thomas Fetherston, Donghee Choi, Soo Heon Kwak, Qingyu Chen, Jaewoo Kang
Journal: npj Digital Medicine (2025)
Characterization of Chronic Lymphocytic Leukemia Immunoglobulin Rearrangements from Partial Read Sequencing
Authors: Azahara Fuentes-Trillo, Alicia Serrano-Alcalá, Blanca Ferrer-Lores, Laura Ventura-López, Enrique Seda, Ana-Bárbara García-García, Blanca Navarro, María José Terol, Felipe Javier Chaves
Journal: Genomics Proteomics & Bioinformatics (2025)
Overall Survival in EGFR-mutant Advanced Non-Small Cell Lung Cancer Treated with First-line Osimertinib: A Cohort Study Integrating Clinical and Biomarker Data in the United States
Authors: Joshua K Sabari, Helena A Yu, Parthiv J Mahadevia, Yanfang Liu, Levon Demirdjian, Yen Hua Chen, Xiayi Wang, Antonio Passaro
Journal: Journal of Thoracic Oncology (2025)
Radiation-guided nanoparticles enhance the efficacy of PARP inhibitors in primary and metastatic BRCA1-deficient tumors via Immunotherapy
Authors: Rami Khoury, Giuseppe Longobardi, Tania Barnatan, Dana Venkert, América García Alvarado, Adi Yona, Marina Green Buzhor, Shir Shahar, Qiwei Wang, Rita C Acúrcio, Rita C Guedes, Helena F Florindo, Jean J Zhao, Ronit Satchi-Fainaro
Journal: Journal of Controlled Release (2025)
Metal phenolic networks-driven bufalin homodimeric prodrug nano-coassemblies for ferroptosis-augmented tumor therapy
Authors: Fei Wu, Chunxue Song, Hanxiao Yin, Ronglong Chen, Guanyu Huang, Jiajun Zhang, Haimin Chen, Li Lin, Junqiang Yin, Lisi Xie, Weihai Liu
Journal: Journal of Controlled Release (2025)
Characterization and comparative analysis of multifunctional natural killer cell engagers during antitumor responses
Authors: Hang Lin, Ryan Case, Kathy Y Wei, Ittai Eres, Benjamin M Alba, Joelle Kaner, Yen-Chi Wu, Tracy M Yamawaki, Mina Mostafavi, Hong Zhou, Hayley Ma, Paolo Manzanillo, Weiwen Deng
Journal: Cell Reports Medicine (2025)

T cell engagers (TCEs) are transformational oncology therapies but are limited in use due to the induction of cytokine release syndrome (CRS). In comparison to T cells, natural killer (NK) cells produce fewer cytokines upon activation, leading to the exploration of NK cell engagers (NKCEs). However, why NK cells secrete fewer cytokines, such as tumor necrosis factor (TNF), and how NKCEs perform directly against TCEs remains unclear. Here, we report that relative to T cells, NK cells have reduced trafficking and processing of TNF. Systematic development and benchmarking studies show that NKCEs can be optimized to engage multiple activating receptors and incorporate interleukin (IL)-2, thereby increasing their potency and durability. Furthermore, comparative studies of NKCE, IL-2, and TCE therapy in animal tumor models reveal both common and distinct therapeutic benefits. Our results provide a blueprint for the development of multifunctional NKCEs, which may serve as an alternative to current TCE therapies.
Long-term Exposure to Air Pollution and Incidence of Type 2 Diabetes in the Nurses’ Health Study and Nurses’ Health Study II
Authors: Melissa R Fiffer, Jie Chen, Emily L Silva, Rachel C Nethery, Qi Sun, Peter James, Stephanie T Grady, Jeff D. Yanosky, Joel D. Kaufman, Francine Laden, Jaime E Hart
Journal: Environmental Health Perspectives (2025)

Research has detected associations between air pollution exposure and type 2 diabetes (T2DM), but findings from large cohort studies are needed to ascertain the most influential pollutants, susceptible subpopulations, and low-level exposure associations. Our aim was to prospectively evaluate the association between long-term exposure to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) and T2DM incidence in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHSII) cohorts of U.S. women. Monthly PM2.5 and NO2 exposures were predicted from spatiotemporal models and linked to participants' residential addresses. We used Cox proportional hazards models to assess the association between 24-month moving average PM2.5 and NO2 exposure and self-reported, clinician diagnosed T2DM from 1992-2019. We adjusted for time-varying lifestyle factors, reproductive hormonal factors, and individual and neighborhood socioeconomic status (SES). Results were meta-analyzed. We evaluated whether relationships persisted at levels below the current U.S. EPA National Ambient Air Quality Standards (NAAQS). Lastly, we examined multiplicative and additive interactions by body mass index (BMI), smoking status, physical activity, neighborhood SES, and region. Over follow-up, there were 19,083 incident T2DM cases among the 208,733 women in NHS and NHSII. In fully-adjusted single pollutant models, the HR for an interquartile range (IQR=4.9 µg/m3) higher 24-month average PM2.5 exposure was 1.05 (95% CI: 1.02, 1.08) for incident T2DM. The HR for an IQR (7.3 ppb) higher NO2 exposure was 1.05 (95% CI: 1.01, 1.09). Both associations were robust to co-adjustment. Associations remained stable when restricting to PM2.5 levels below the NAAQS as compared to the full dataset. Stronger associations were observed in individuals who had a BMI ≥30, were physically active, and resided in the Northeast. Our results showed a positive association between T2DM and long-term exposure to PM2.5 and NO2, persisting even at levels below the current EPA NAAQS. https://doi.org/10.1289/EHP15673.
Inflammasome signaling in astrocytes modulates hippocampal plasticity
Authors: Kristine E Zengeler, Ava Hollis, Tyler C J Deutsch, Joshua D Samuels, Hannah Ennerfelt, Katelyn A Moore, Eric J Steacy, Vikram Sabapathy, Rahul Sharma, Manoj K Patel, John R Lukens
Journal: Immunity (2025)