ALLOXAN IN THE TREATMENT OF A CASE OF ISLET CELL CARCINOMA OF THE PANCREAS WITH LIVER METASTASES
Authors: L B FLINN, E MINNICK, D M GAY
Journal: Annals of Internal Medicine (1947)

Case Reports1 June 1947ALLOXAN IN THE TREATMENT OF A CASE OF ISLET CELL CARCINOMA OF THE PANCREAS WITH LIVER METASTASESLEWIS B. FLINN, M.D., F.A.C.P., EDWARD MINNICK, M.D., DOUGLAS M. GAY, M.D.LEWIS B. FLINN, M.D., F.A.C.P.Search for more papers by this author, EDWARD MINNICK, M.D.Search for more papers by this author, DOUGLAS M. GAY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-6-936 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOrganic hyperinsulinism has been recognized with increasing frequency in the last few years. It is most commonly due to adenomata of the islands of Langerhans. More and more case reports appear of successful surgical removal of these tumors with consequent alleviation of symptoms. At times there seems to be a general hypersecretion of insulin by the islet cells without discernible tumor in which resection of varying amounts of pancreatic tissue has been found effective. Carcinoma of islet cells occurs much less frequently. In these cases the tumor is often slow to grow and slow to metastasize. In a few instances...Bibliography1. FLINNBEATTYGINSBERGHEMSATH LBGAMFA: Carcinoma of the islands of Langerhans with hypoglycemia and metastasis to the liver, Jr. Am. Med. Assoc., 1941, cxvii, 283-285. CrossrefGoogle Scholar2. BRUNSCHWIGALLENOWENSTHORNTON AJGFMTF: Alloxan in the treatment of insulin producing islet cell carcinoma of the pancreas, Jr. Am. Med. Assoc., 1944, cxxxiv, 212-216. CrossrefGoogle Scholar3. DUNNSHEEHANMCLETCHIE JSHLN: Necrosis of islets of Langerhans produced experimentally, Lancet, 1943, i, 484-487. Google Scholar4. BRUNSCHWIGALLEN AJG: Specific injurious action of alloxan upon pancreatic islet cells and convoluted tubules of the kidney. Comparative study in the rabbit, dog and man, Cancer Res., 1944, iv, 45-59. Google Scholar5. JOSLIN EP: Medical progress—Diabetes mellitus, New Eng. Jr. Med., 1944, ccxxx, 425-431. CrossrefGoogle Scholar6. HOUSSAYORIASSARA BAOI: The mechanism of action of alloxan on blood sugar, Science, 1945, cii, 197. CrossrefGoogle Scholar7. GOLDNERGOMARI MGG: Alloxan diabetes in dog, Endocrinology, 1943, xxxiii, 297-308. CrossrefGoogle Scholar8. BAILEYBAILEYLEECH CCOTRS: Alloxan diabetes with diabetic complications, New Eng. Jr. Med., 1944, ccxxx, 533-536. CrossrefGoogle Scholar9. BAILEYHAGAN CCWH: Alloxan diabetes in rabbits. Consideration of morphologic and physiologic changes, Am. Jr. Med. Sci., 1944, ccviii, 450-461. CrossrefGoogle Scholar10. HUGHESWAREYOUNG HLLFG: Diabetogenic action of alloxan, Lancet, 1944, 148-150. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 30, 1946. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlloxan Treatment and Insulin Secretion in Refractory Neonatal HypoglycemiaMALIGNANT METASTATIC INSULINOMA TREATED WITH STREPTOZOTOCIN.Der experimentelle DiabetesInsulin-Secreting Tumors of the Pancreas: A Diagnostic and Therapeutic ChallengeDer experimentelle chemische DiabetesIslet-cell Carcinoma Treated with Alloxan Associated with Calcified Hepatic Metastases and Thyrotoxic MyopathyFREDERICK E. ZIMMER, M.D., F.A.C.P.Islet cell tumors of the pancreas and hyperinsulinismCarcinomrezidivoperationenSpontaneous hypoglycemiaMalignant Insuloiiia with HyperinsnlinismINSULOMASAlloxanwirkungen bei einem InselzelltumorHyperinsulinismus und Inselzelltumoren des PankreasAlloxan DiabetesDiabetes 1 June 1947Volume 26, Issue 6Page: 936-945KeywordsHepatocellular carcinomaHyperinsulinemiaInsulinPancreasTumor resection ePublished: 1 December 2008 Issue Published: 1 June 1947 PDF downloadLoading ...