tbuckley/cabot-search huggingface dataset:
Restoration of physiological concentrations of 25-OH-vitamin D (25-OH-D) enables calcitriol (1,25-OH2-D) production in hemodialysis (HD) patients: evidence from a multicenter randomized controlled trial
Authors: Annick Massart, Karl Martin Wissing, Michel D'haene, Joëlle Nortier, Frédéric Debelle
Journal: Journal of the American Society of Nephrology (2010)
Large maculopapular cutaneous lesions are associated with favorable outcome in childhood-onset mastocytosis
Authors: Tim Wiechers, Anja Rabenhorst, Tina Schick, Liane M. Preussner, Anja Förster, Peter Valent, Hans-Peter Horny, Karl Sotlar, Karin Hartmann
Journal: Journal of Allergy and Clinical Immunology (2015)
Abstract 4006: Spontaneous Dissections of Coronary Arteries (SCAD) and Acute Coronary Syndromes (ACS). Preliminary Results of the Discovery-ACS: A Multicenter Prospective Registry With A Patients-control Group
Authors: Alessandro Fontanelli, Alessandra Benettin, Carlo Bonanno, Ester Cabianca, Alessandro Desideri, Andrea Santarelli, Luigi La Vecchia, Leopoldo Pagliani
Journal: Circulation (2008)

Background: Spontaneous coronary artery dissection (SCAD) is an unusual cause of myocardial ischemia and sudden death. We report the preliminary data of the DISCOVERY (DISsection of the COronary ar...
Novel Biomarkers of Cardiac Stress, Cardiovascular Dysfunction, and Outcomes in HIV-Infected Individuals
Authors: Eric A Secemsky, Rebecca Scherzer, Elaine Nitta, Alan H B Wu, David C Lange, Steven G Deeks, Jeffrey N Martin, James Snider, Peter Ganz, Priscilla Y Hsue
Journal: JACC Heart Failure (2015)
Is primary tumour standardizeds uptake volume (SUV) an independent prognostic factor for NSCLC
Authors: Marianne Paesmans, Cyo Wong, E.F. Patz, R. Komaki, S. Eshmann, R. Govidan, J. Van Steekiste, Anne-Pascale Meert, W.A de Jong, K. Higashi, G. Borst, A. Van Baardwyk, Laurent Ameye, Jean-Jacques Lafitte, Thierry Berghmans, Camilo Garcia, Pierre Flament, Patrick Flamen, R. Rami Porta, Jean-Paul Sculier
Journal: European Respiratory Journal (2011)
Efficacy and Safety Of Fedratinib (SAR302503/TG101348) In Patients With Intermediate- Or High-Risk Myelofibrosis (MF), Post-Polycythemia Vera (PV) MF, Or Post-Essential Thrombocythemia (ET) MF Previously Treated With Ruxolitinib: Interim Results From a Phase II Study (JAKARTA-2)
Authors: Claire N Harrison, Nicolaas PM Schaap, Sonja Zweegman, Eric Jourdan, Jean-Jacques Kiladjian, Francisco Cervantes, Dietger Niederwieser, Jorge E. Cortes, Francesco Passamonti, Andreas Reiter, Christian Recher, Konstanze Döhner, Florian H Heidel, Richard T. Silver, Elliott F Winton, Vikas Gupta, Emilio Ojeda, Heinz Gisslinger, Alessandro M. Vannucchi, Moshe Talpaz, Jenny Zhang, Weiliang Shi, Ruben A. Mesa
Journal: Blood (2013)
Most genitourinary physicians are trained in family planning
Authors: D. Nunns, D Mandal
Journal: BMJ (1995)

EDITOR,—Yvonne Stedman and Max Elstein seem not to appreciate that an integrated model of care for sexual health already exists.1 One example is our department of sexual health in Bolton, where we have an integrated and comprehensive range of care. This includes a genitourinary medicine service; family planning; a sexual dysfunction clinic; primary, secondary, and tertiary intervention …
The Delayed Type of Allergic Reaction
Authors: Robert A. Cooke
Journal: Annals of Internal Medicine (1930)

Article1 January 1930The Delayed Type of Allergic ReactionROBERT A. COOKEROBERT A. COOKESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-7-658 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI thought it might be interesting to present, together with some illustrative cases, a type of hypersensitive reaction in man that has been little appreciated and is not well understood. The usual clinical conditions of asthma and hay fever are, generally speaking, immediate reactions; that is, the attack is precipitated very quickly within from one to thirty minutes after contact with the substance to which sensitiveness exists. In these cases the diagnostic skin test with this substance is also immediately positive, giving the typical urticarial wheal. It is in this group with the immediate clinical + test reactions that the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Boston Meeting of the American College of Physicians, April 10, 1929. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFood Sensitivities and Psychological Disturbance: a ReviewCLINICAL SENSITIVITIES TO GELATIN AND OTHER MEAT PRODUCTSThe immunology of allergic diseaseDie klinische Bedeutung des Tuberkulins 1 January 1930Volume 3, Issue 7Page: 658-661KeywordsAllergy and immunologyAsthmaFeversSkin tests ePublished: 1 December 2008 Issue Published: 1 January 1930 PDF downloadLoading ...
Differential influences of high fat diet on cardiac remodeling from normotensive and spontaneously hypertensive rats
Authors: S. A. Oliveira Junior, A. P. Lima-Leopoldo, P. F. Martinez, D. H. S. Campos, M. M. Sugizaki, Marina Politi Okoshi, Katashi Okoshi, Carlos Roberto Padovani, M. Dal Pai-Silva, Antonio Carlos Cicogna
Journal: Circulation (2008)
Study should have been randomised
Authors: B. A Loughnan, H. Gordon, A. O Frank
Journal: BMJ (1996)

EDITOR,—We wish to make several comments about Robin Russell and colleagues' study looking at possible factors in long term backache after childbirth.1 Firstly, the study was not randomised with respect to controls, and the authors justify this by stating that randomisation would have been unethical. We would argue that a randomised controlled trial is the only way to validate the use of …
SOME DESIRABLE SUPPLEMENTS TO THE PRESENT TRENDS IN MEDICAL INVESTIGATION
Authors: Roger I. Lee
Journal: Annals of Internal Medicine (1938)

Article1 November 1938SOME DESIRABLE SUPPLEMENTS TO THE PRESENT TRENDS IN MEDICAL INVESTIGATIONROGER I. LEE, M.D., F.A.C.P.ROGER I. LEE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-5-692 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTruly the advances in Medicine have been prodigious in the last few generations. These advances have taken place on a broad front and continually make possible the utilization not only of the so-called basic Medical Sciences but also of all branches of sciences for the understanding of disease and, indeed, often for application at the bedside.The changing situation has developed in internal medicine new attitudes and new standards. It is not too much to say that a new specialty has appeared, that of the medical investigator. Within 50 years, to meet the needs of these medical investigators, Medical Schools... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read before the American College of Physicians, New York City, April 4, 1938. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1938Volume 12, Issue 5Page: 692-698 Issue Published: 1 November 1938 PDF downloadLoading ...
Abstract 3981: Efficacy and Safety of Varenicline, an {alpha}4{beta}2 Acetylcholine Nicotinic Receptor Partial Agonist, for Smoking Cessation in Japanese Smokers
Authors: Masakazu Nakamura, Yoko Fujimoto, Nami Maruyama, Taro Ishibashi, Karen Reeves
Journal: Circulation (2006)
CEREBRAL VASOTHROMBOSIS IN CARDIAC DISEASES: CLINICOPATHOLOGIC STUDY
Authors: I M SCHEINKER
Journal: Annals of Internal Medicine (1955)

Article1 January 1955CEREBRAL VASOTHROMBOSIS IN CARDIAC DISEASES: CLINICOPATHOLOGIC STUDYI. M. SCHEINKER, M.D.I. M. SCHEINKER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-1-128 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCerebral manifestations in acute and chronic heart failure are not uncommon. The underlying pathology may consist of widespread areas of softening disseminated throughout one or both hemispheres. Hemiplegias, aphasias and other clinical syndromes have been observed during or following an acute phase of cardiac failure.1The purpose of this presentation is to call attention to the frequent occurrence of thrombotic occlusion of small cerebral veins in cases of chronic heart failure. The vascular alteration described as "cerebral vasothrombosis"2is characterized by thrombotic occlusion of extremely distended and congested small veins. The thrombi are composed of curved strands of fibrin mixed...Bibliography1. Scheinker IM: Medical neuropathology, 1952, Charles C. Thomas, Springfield, Illinois, pp. 3-58. Google Scholar2. Scheinker IM: Vasothrombosis of the central nervous system, Arch. Neurol. and Psychiat. 53: 171, 1945. CrossrefGoogle Scholar3. EckerDeren ADM: Apoplexy apparently precipitated by low blood pressure, Am. J. M. Sc. 201: 415, 1941. CrossrefGoogle Scholar4. WolfSiris AJ: Acute non-traumatic encephalomalacia complicating neurosurgical operations in the sitting position, Bull. Neurol. Inst. New York 6: 42, 1937. Google Scholar5. Lewis N: Psychic phenomena in association with cardiac failure, Arch. Neurol. and Psychiat. 37: 782, 1937. CrossrefGoogle Scholar6. Wortis J: Cardiac psychosis and the symptoms of anxiety, Am. Heart J. 13: 394-412, 1937. CrossrefGoogle Scholar7. HarveyFinch WPCA: Dicumarol prophylaxis of thromboembolic disease in congestive heart failure, New England J. Med. 242: 208-211 (Feb. 9) 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication June 1, 1954.From the Department of Neurology and Neurosurgery, New York Medical College, Flower and Fifth Avenue Hospitals.†Deceased. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySPONTANEOUS CEREBRAL HAEMORRHAGE AND ENCEPHALOMALACIA. A Clinico-Pathological Study of 263 Cases with Special Reference to Cardiovascular Diseases and Cerebral AtherosclerosisThe Treatment of Cerebrovascular AccidentRecent Advances in the Investigation and Management of Cerebrovascular Disease 1 January 1955Volume 42, Issue 1Page: 128-135KeywordsFibrinHeart diseasesHeart failureNeurologyNeurosurgeryVeins ePublished: 1 December 2008 Issue Published: 1 January 1955 PDF downloadLoading ...
Molecular cytogenetic characterization of anaplastic thyroid carcinoma
Authors: Jia-Jing Lee, Theodoros Foukakis, Weng-Onn Lui, Jamileh Hashemi, Nils-Erik Heldin, Lars Grimelius, Göran Wallin, Anders Höög, Catharina Larsson
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4208 

Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers, with a median survival of just a few months after diagnosis. The underlying genetic events and pathogenesis of ATC are vastly unknown. To further delineate the role of chromosomal aberrations in ATC, we performed cytogenetic analyses of eight established cell lines (Hth104, SW1736, Hth74, Hth7, Kat4, C643, Hth83 and Hth112) using spectral karyotyping (SKY), G-banding, comparative genomic hybridization (CGH) and array-CGH. Gain of chromosome 20q was observed in six of the eight ATC cell lines studied, with 2 cell lines showing high amplification of this chromosomal region. This region involved was further confirmed and narrowed by array-CGH. The copy number changes detected by CGH correlated well with the karyotypic findings by SKY and G-banding. All cell lines have a multitude of karyotypic alterations. Amongst the structural aberrations detected, isoderivative chromosome 13 and del(5)(q11) were most frequently observed. Interestingly, we found a cell line (Hth74) with a translocation t(3;8) involving 3p21, a region harboring several candidate tumor suppressor genes. Kat4 exhibited a translocation t(3;15)(?q25;q26). We have previously reported the presence of a 15q26 aberration in another anaplastic cell line (ARO) as well as in a primary papillary thyroid carcinoma (PTC). The structural and numerical aberrations identified by the cell line characterizations here provide evidence of chromosomal regions involved in the development of ATC and/or progression of the differentiated thyroid cancers to ATC. Further characterization of the observed aberrations may lead to the identification of novel fusion oncogenes and/or candidate genes in thyroid anaplastic transformation and the progressive pathway.
Abstract 1746: Alterations in Transmural Myocardial Strain: An Early Marker of Left Ventricular Dysfunction in Mitral Regurgitation?
Authors: Tom C Nguyen, Carl J Carlhall, Akinobu Itoh, Robert A Oakes, Daniel B Ennis, Wolfgang Bothe, David Liang, George T Daughters, Neil B Ingels, David C Miller
Journal: Circulation (2007)

INTRODUCTION:  In asymptomatic patients with severe mitral regurgitation (MR), identifying subclinical LV dysfunction can guide the timing of surgical repair. We hypothesized that changes in LV transmural myocardial strain represent early markers of LV dysfunction in an ovine chronic MR model of low pressure volume overload.   METHODS:  Twenty sheep were randomized to control (CTRL, n=8) or experimental (EXP, n=12) groups. In EXP, a 3.5– 4.8mm hole was created in the posterior mitral leaflet to generate “pure” MR. Thirteen radiopaque markers were surgically implanted to silhouette the LV chamber, and LV myocardial strains were measured using transmural bead columns inserted into the lateral equatorial and anterobasal LV walls. One and 12 weeks thereafter, 4-D marker coordinates every 17 msec were obtained radiographically in closed-chest, anesthetized conditions. Transmural normal strains were calculated from bead displacements along circumferential (E CC ), longitudinal (E LL ), and radial (E RR ) axes during systole and diastolic filling.   RESULTS:  MR grade was higher in EXP versus CTRL at both 1 and 12 weeks (3.0±0.4 vs. 0.7±0.8; 2.7±0.9 vs. 0.5±0.5, respectively, both P 2 , P 2 , P LL  (lateral: −0.08±0.05 vs. 0.02±0.14; anterior: −0.10±0.05 vs. −0.02±0.07, respectively, both P LL  (anterior: −0.09±0.07 vs. −0.02±0.05, p   CONCLUSIONS:  Twelve weeks of “pure” MR in this ovine model caused LV remodeling. Early changes in LV function were detected by longitudinal diastolic filling strains, but not by BNP, PRSW or tau. These alterations in transmural strains may prove useful in the clinical evaluation of latent LV dysfunction in asymptomatic patients with severe MR.
Utility of prostate specific antigen doubling time (PSA-DT) at the start of androgen independent prostate cancer (AIPC) and immediately before chemotherapy in predicting efficacy of taxane chemotherapy
Authors: M. M. Regan, T. J. Daskivich, P. W. Kantoff, W. K. Oh
Journal: Journal of Clinical Oncology (2006)

4640 Background: PSA-DT has been used to predict efficacy of various treatments for prostate cancer. No study has evaluated the ability of PSA-DT to predict efficacy of taxane chemotherapy, the standard of care for patients with metastatic AIPC. Methods: PSA-DT was retrospectively calculated in 148 AIPC patients treated with taxane chemotherapy. PSA-DT at the start of AIPC (PSA-DT “at AIPC”) was calculated as log 2 divided by the slope of the linear regression of log PSA vs. time, from the first rise above the PSA nadir on androgen deprivation therapy (ADT) until the start of the next treatment. PSA-DT immediately prior to chemotherapy (“pre-chemotherapy” PSA-DT) was calculated similarly, using the three PSA values closest to and no longer than three months before the start of taxane chemotherapy. PSA-DT was divided into tertiles for analysis. Primary outcome was response to chemotherapy, defined as &gt;50% maximum percent reduction in PSA from the start of chemotherapy and was analyzed using logistic regression. Results: PSA-DT at AIPC and pre-chemotherapy PSA-DT could be calculated for 91 and 109 patients, respectively. Rapid pre-chemotherapy PSA-DT (&lt;5 wks) showed a trend towards higher &gt;50% PSA response rates, when compared with intermediate (5–10 wks) and slow PSA-DT (≥10 wks) (74%, 62%, 54%, respectively, P = 0.08 for trend). At androgen independence, rapid PSA-DT (≤ 6 wks) also showed higher &gt;50% PSA response rates than intermediate (6–12 wks) or slow PSA-DT (&gt;12 wks) (81%, 61%, and 62%, respectively) but were not significantly different (P = 0.07, ≤6 vs. &gt;6 wks). Conclusions: Short PSA-DT directly before taxane chemotherapy and also at androgen independence shows a trend towards higher &gt; 50% PSA response rates. PSA-DT at these timepoints will be important to analyze in larger prospective studies. No significant financial relationships to disclose.
HLA-B8 and HLA-A3 Coexpressed With HLA-B8 Are Associated With a Reduced Risk of the Development of Chronic Myeloid Leukemia
Authors: E.F.M. Posthuma, J.H.F. Falkenburg, J.F. Apperley, A. Gratwohl, E. Roosnek, B. Hertenstein, R.F. Schipper, G.M.T. Schreuder, J. D’Amaro, M. Oudshoorn, J.H. v Biezen, J. Hermans, R. Willemze, D. Niederwieser
Journal: Blood (1999)
Acute 3T Magnetic Resonance Imaging Reveals Features of Carotid Atherosclerotic Plaque Associated with Ipsilateral Cerebral Infarction in Minor Stroke and Transient Ischemic Attack
Authors: Alistair C Lindsay, Luca Biasiolli, Justin M Lee, Ilias Kylilntireas, Bradley J MacIntosh, Hilary Watt, Peter Jezzard, Matthew D Robson, Stefan Neubauer, Ashok Handa, James Kennedy, Robin P Choudhury
Journal: Circulation (2011)
Late Restenosis After Paclitaxel-Coated Balloon Angioplasty Occurs in Patients With Drug-Eluting Stent Restenosis
Authors: Seiji Habara, Kazushige Kadota, Takenobu Shimada, Masanobu Ohya, Hidewo Amano, Yu Izawa, Shunsuke Kubo, Yusuke Hyodo, Suguru Otsuru, Daiji Hasegawa, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2015)
PRIMARY HYPERTENSION IN THE ELDERLY
Authors: G A PERERA
Journal: Annals of Internal Medicine (1959)

Article1 September 1959PRIMARY HYPERTENSION IN THE ELDERLYGEORGE A. PERERA, M.D., F.A.C.P.GEORGE A. PERERA, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-3-537 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough most of the clinical and pathologic surveys of primary (essential) hypertension in the literature indicate that the average age at death is in the sixth decade, it is common knowledge that many patients survive for considerably longer periods and may have a normal life expectancy.1 The present study was undertaken to examine the clinical characteristics of those who live past the age of 60.CLINICAL MATERIALAll cases were selected from the records of the Presbyterian Hospital. One hundred patients were found with established diastolic hypertension2(repeated diastolic blood pressure values of 90 mm. of Hg or higher) who...Bibliography1. Perera GA: Hypertensive vascular disease; description and natural history, J. Chron. Dis. 1: 33, 1955. CrossrefMedlineGoogle Scholar2. BrustPereraWilkins AAGARW: Classification of types of hypertension. Report to the Council on Drugs, J. A. M. A. 166: 640, 1958. MedlineGoogle Scholar3. Perera GA: Relation of blood pressure lability to prognosis in hypertensive vascular disease, J. Chron. Dis. 1: 121, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication March 13, 1959.From the Department of Medicine, Columbia University College of Physicians and Surgeons, and the Presbyterian Hospital, New York.†This study was supported by grants from the Albert H. and Jessie D. Wiggin Foundation, and the Union County (New Jersey) Heart Association.Requests for reprints should be addressed to George A. Perera, M.D., Department of Medicine, Columbia University College of Physicians and Surgeons, 620 West 168th Street, New York 32, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypertensive cardiovascular disease 1 September 1959Volume 51, Issue 3Page: 537-540KeywordsBlood pressureHeartHospital medicineHypertensionLife expectancyLongitudinal studiesPrimary hypertensionSurgeons ePublished: 1 December 2008 Issue Published: 1 September 1959 PDF downloadLoading ...
THE CONTROL OF RESPIRATORY INFECTIONS
Authors: F S BRIEN
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5953: Flow Pulsation Affect Distal Pulmonary Artery Endothelial Cell mRNA Expression
Authors: Min Li, Kurt Stenmark, Robin Shandas, Wei Tan
Journal: Circulation (2008)

Background: Due to the development of pulmonary arterial hypertension (PAH), distal pulmonary artery endothelial cells (dPAEC) are exposed to wall shear stress (SS) that is different in physical characteristics compared to normal condition. The effect of individual components of SS on PAEC biology has not been thoroughly examined. Thus the current study was designed to examine how dPAEC respond to different component of SS in regarding to gene expression including adhesion molecules: ICAM, VCAM, E-selectin; chemokine: MCP-1 and growth factors:VEGF, Flt-1. Methods: Bovine dPAEC were cultured and placed on fibronectin-coated slides till confluent. Cells were then exposed to SS with different frequency (1Hz, 2Hz), pulsation (low, medium and high with an average SS of 14 dynes/cm 2 ) and time (1hr or 6hrs). The flow studies were carried out using a flow chamber connected to a variable speed flow pump. All data was represented as fold change relative to static condition. Results: As shown in table below, The effect of flow frequency on gene expression depends on individual gene. There was no difference of ICAM expression between 1Hz and 2Hz. Frequency of 2Hz significantly increased VCAM and MCP-1 expression compared to frequency of 1Hz. Compared to static condition, steady flow increased all gene expression. One hour pulsatile flow further increased ICAM, VCAM, E-selectin and MCP-1 but not VEGF or Flt-1 expression as pulsation increased. 3) Prolonged pulsatile flow further increased all gene expression. Conclusion: Physical characteristics of flow, especially flow pulsation stimulate dPAEC gene expression which can contribute to the development of PAH.