tbuckley/cabot-search huggingface dataset:
Comparison of lenalidomide in combination with dexamethasone to dexamethasone alone in patients who have received prior thalidomide in relapsed or refractory multiple myeloma
Authors: M. Wang, R. Knight, M. Dimopoulos, D. Siegel, S. V. Rajkumar, T. Facon, Z. Yu, J. Zeldis, M. Olesnyckyj, D. M. Weber
Journal: Journal of Clinical Oncology (2006)

7522 Background: Lenalidomide (len), an analog of thalidomide (thal) is a novel, oral immunomodulatory agent that is effective against multiple myeloma (MM). Two randomized, Phase III trials (MM009 and MM010) have recently demonstrated superior responses and overall survival (OS) for patients (pts) treated with len and dexamethasone (dex) in comparison with dex-placebo. This is a prospective subgroup analysis to assess the impact of prior therapy with thal on the sensitivity of MM to subsequent lenalidomide. Methods: We evaluated 692 pts from both trials (MM009 and MM010). The pts had relapsed/refractory MM, were not refractory to dex and were randomized to receive either len (25 mg daily for 3 weeks (wks) every 4 wks) plus dex (40 mg on days 1–4, 9–12, 17–20 every 4 wks for 4 cycles, then 40 mg on days 1–4 every subsequent cycle) or placebo plus dex. Standard criteria were used to evaluate response and TTP. Results: Pooled data from 692 pts showed superior median TTP (48.1 vs 20.1 wks) and OR (59.2% vs 22.5%) in pts treated with len/dex compared to dex-placebo (p &lt;0.001). Although subgroup analysis of pts with prior thal therapy revealed that pts who received len/dex had significantly improved OR, PR CR and median TTP than pts who received dex-placebo, OR, CR and TTP were highest in len/dex pts not previously treated with thal. Multivariate analysis indicates that after controlling for the treatment factor and baseline disease characteristics, whether or not pt had prior exposure to thal is a marginally significant variable to predict TTP. The risk of deep venous thrombosis and pulmonary embolism in these subgroups will be updated on further analysis. Conclusions: Lenalidomide in combination with dexamethasone is more effective than dexamethasone-placebo regardless of prior thalidomide in relapsed/refractory multiple myeloma. [Table: see text] [Table: see text]
Modulating Bone Resorption and Bone Formation in Opposite Directions in the Treatment of Postmenopausal Osteoporosis
Authors: Natasha M. Appelman-Dijkstra, Socrates E. Papapoulos
Journal: Drugs (2015)

Bone remodeling, the fundamental process for bone renewal, is targeted by treatments of osteoporosis to correct the imbalance between bone resorption and bone formation and reduce the risk of fractures and associated clinical consequences. Currently available therapeutics affect bone resorption and bone formation in the same direction and either decrease (inhibitors of bone resorption) or increase (parathyroid hormone [PTH] peptides) bone remodeling. Studies of patients with rare bone diseases and genetically modified animal models demonstrated that bone resorption and bone formation may not necessarily be coupled, leading to identification of molecular targets in bone cells for the development of novel agents for the treatment of osteoporosis. Application of such agents to the treatment of women with low bone mass confirmed that bone resorption and bone formation can be modulated in different directions and so far two new classes of therapeutics for osteoporosis have been defined with distinct mechanisms of action. Such treatments, if combined with a favorable safety profile, will offer new therapeutic options and will improve the management of patients with osteoporosis.
Evidence of ETNK1 Somatic Variants in Atypical Chronic Myeloid Leukemia
Authors: Carla Donadoni, Rocco Piazza, Diletta Fontana, Andrea Parmiani, Alessandra Pirola, Sara Redaelli, Giovanni Signore, Vincenzo Piazza, Luca Malcovati, Roberta Spinelli, Vera Magistroni, Giuseppe Gaipa, Marco Peronaci, Alessandro Morotti, Cristina Panuzzo, Giuseppe Saglio, Elena Maria Elli, Emilio Usala, Dong-Wook Kim, Delphine Rea, Konstantinos Zervakis, Nora-Athina Viniou, Argiris Symeonidis, Heiko Becker, Jacqueline Boultwood, Leonardo Campiotti, Matteo G Carrabba, Graham R Bignell, Elli Papaemmanuil, Peter J Campbell, Mario Cazzola, Carlo Gambacorti-Passerini
Journal: Blood (2014)
Survival Prediction of Clear Cell Renal Cell Carcinoma Based on Gene Expression Similarity to the Proximal Tubule of the Nephron
Authors: Florian Büttner, Stefan Winter, Steffen Rausch, Anna Reustle, Stephan Kruck, Kerstin Junker, Arnulf Stenzl, Abbas Agaimy, Arndt Hartmann, Jens Bedke, Matthias Schwab, Elke Schaeffeler
Journal: European Urology (2015)
Klinische Konstitutionslehre: Ein Lehrbuch über die Beziehungen zwischen Körperverfassung und Krankheit für Studierende und Ärzte.
Authors: L. Borchardt
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 13853: Systolic Function and the Transvalvular Mean Gradient in Patients with Severe Aortic Stenosis: Role of Left Ventricular Twist and Longitudinal Systolic Strain
Authors: Brian R Lindman, Suzanne V Arnold, Jose A Madrazo, Stephanie N Johnson, Eric Novak, Mark R Holland, Tara A Hohn, Alan Zajarias, James G Miller, Julio E Perez
Journal: Circulation (2011)

Background: In patients with severe aortic stenosis (AS) (AVA <1.0 cm2), a low transvalvular mean gradient (MG) portends a worse prognosis. A low MG is associated with a low flow state, which is of...
The Ventricle: Basic and Clinical Aspects.
Authors: Herbert J. Levine, William H. Gaasch
Journal: Annals of Internal Medicine (1987)

1. Pathologic Anatomy of Acquired Ventricular Disease.- 2. Mechanics of Ventricular Muscle.- 3. The Biochemistry of Excitation-Contraction Coupling: Implications with Regard to Pump Failure.- 4. Ventricular End-Systolic Pressure-Volume Relations.- 5. Autonomic Reflex Control of Cardiac Contractility.- 6. Ventricular Relaxation.- 7. Diastolic Properties of the Left Ventricle.- 8. Ventricular Interaction and the Pericardium.- 9. Experimental Myocardial Hypertrophy.- 10. Pathophysiology of Heart Failure.- 11. Pressure Overload: Human Studies.- 12. Chronic Aortic and Mitral Regurgitation: Mechanical Consequences of the Lesion and the Results of Surgical Correction.- 13. The Coronary Circulation in Ventricular Hypertrophy.- 14. Ventricular Function in Ischemia and Infarction and Following Reperfusion.- 15. Current Status of Interventions Designed to Limit Infarct Size.- 16. Vasoactive Drugs and the Failing Ventricle.
Abstract 1015: Frequency of Diastolic Third and Fourth Heart Sounds with Myocardial Ischemia during Percutaneous Coronary Intervention
Authors: Eunyoung Lee, Andrew D Michaels, Ronald H Selvester, Barbara J Drew
Journal: Circulation (2008)

Background: Although the standard 12-lead ECG is considered the gold standard to diagnose acute myocardial ischemia, nearly half of ECGs are non-diagnostic in patients who present with chest pain a...
The Book of Poultry.
Authors: Thomas Fletcher McGrew
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Radiology of the Pediatric Abdomen and Gastrointestinal Tract.
Authors: Rolf L. Schapiro, Edward T. Evans, Joanna J. Seibert, David L. Kiple
Journal: Annals of Internal Medicine (1977)

In his modest preface, the author indicates that his book is directed to the general diagnostic radiologist, either in practice or in training, anddisclaimsanypretentions of authority either for himself or the book. Indeed, it is notan erudite or definitive work andthere are many imperfections, but they are offset in nosmalldegree bythe brevityof thetext and its readability. The scope of the text is broad, including the entiregastrointestinal tract, the abdominal wall, the diaphragm, anda chapter on abdominal masses. The latter dwells particularly on masses encountered in the neonatal period but contains much valuable information aboutthoseafflictingchildren generally. Within that chapter is a brief paragraph describing abdominal ultrasound examination and itsscope, including some B-scans, both bistable andgray-scale, whichaddsubstantially to the information conveyed, though the imaging appears poorby present standards. One of thebestchapters is the last, entitled Indwelling Vascular Catheters in Infants, whichis informative and valuable, although the discussion wanders far into the thoraxandthusawayfrom the avowed compass of the book. Some of the reproductions areexcellent, some mediocre, and some plainly poor or inadequate. The excellence of some illustrations indicates that the publisher is unlikelyto be at fault for the poor ones; rather, the printssubmitted were of variable quality. Thefiguresare largeenough to be easilyseenandunderstood, andthe legends are concise. The bibliography is brief, sometimes sparse, and often outdated. There are occasional errors in English and in spelling. Thetype is large,easilyread, andpleasingly set up,sothat the casual or occasional reader canconsult or peruse thebookwith a senseof pleasure. However, it seemsto me that the cost of publishing the book(and thusits price)couldhavebeen abated by moreeconomical useof pagespace: thereare blankpages andblank partsof pages throughout the text. In summary, this book is far from scholarlyor authoritative, but then it was not intended to be. Its superficial and cursory treatment of many subjects will notsatisfy the critical reader or expert in the field, but it presents much useful information in an easily accessible andpleasant manner and will likely be well received by those to whom it is addressed.
William Crawford Gorgas, His Life and Work.
Authors: Marie Cook Gorgas, Burton J. Hendrick
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die Mikrogasanalyse und ihre Anwendung
Authors: Heinrich Schwarz
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Span of Life as Influenced by the Heart, the Kidneys and the Blood Vessels
Authors: Franklin Richards Nuzum
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SPECT Myocardial Blood Flow Quantitation Concludes Equivocal Myocardial Perfusion SPECT Studies to Increase Diagnostic Benefits
Authors: Lung-Ching Chen, Chih-Yuan Lin, Ing-Jou Chen, Chi-Tai Ku, Yen-Kung Chen, Bailing Hsu
Journal: Clinical Nuclear Medicine (2015)

Recently, myocardial blood flow quantitation with dynamic SPECT/CT has been reported to enhance the detection of coronary artery disease in human. This advance has created important clinical applications to coronary artery disease diagnosis and management for areas where myocardial perfusion PET tracers are not available. We present 2 clinical cases that undergone a combined test of 1-day rest/dipyridamole-stress dynamic SPECT and ECG-gated myocardial perfusion SPECT scans using an integrated imaging protocol and demonstrate that flow parameters are capable to conclude equivocal myocardial perfusion SPECT studies, therefore increasing diagnostic benefits to add value in making clinical decisions.
Relationship of childhood anxiety to adult panic disorder: correlates and influence on course
Authors: M H Pollack, M W Otto, S Sabatino, D Majcher, J J Worthington, E T McArdle, J F Rosenbaum
Journal: American Journal of Psychiatry (1996)

This study investigated the correlates of a childhood history of anxiety disorders in adult patients participating in a longitudinal study of panic disorder. The authors hypothesized that a history of anxiety during childhood would be associated with higher rates of comorbid anxiety and depressive disorders, greater likelihood of anxiety disorders in family members, and greater chronicity, as reflected by decreased time spent in remission.The presence of a childhood history of anxiety disorders was assessed by structured interview, and its association with comorbid anxiety and depressive disorders, family history, and select anxiety severity variables was examined in a replication sample of 94 patients. The influence of childhood anxiety on the prospectively ascertained course of disorder was assessed in a full group of 194 patients.Over half (54%) of the patients experienced anxiety disorders during childhood. These patients experienced higher rates of comorbid anxiety and depression, family history of anxiety, and increased levels of agoraphobia, panic frequency, and global severity of illness at baseline evaluation. Childhood anxiety disorders were not independently associated with the number of months in remission or the severity of illness over time, although a modest effect for this variable was evident when degree of avoidance and anxiety sensitivity at baseline were statistically controlled.Adult panic patients with a history of anxiety disorders in childhood have elevated rates of comorbid anxiety and depressive disorders and a tendency toward increased avoidance, but there was not strong evidence that these patients respond differently to treatment over time.
The Differential Diagnosis of Endocrine Disorders.
Authors: Allan Winter Rowe
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reconstructing a Genotype-Phenotype Map In Chronic Lymphocytic Leukemia
Authors: Dylan Kotliar, Dan-Avi Landau, Oren Litvin, Petar Stojanov, Carrie Sougnez, Gordon Saksena, M. Eng, Donna S. Neuberg, Gad Getz, Jennifer R Brown, Dana Pe'er, Nir Hacohen, Catherine J. Wu
Journal: Blood (2013)
Comparison of erythroid response (ER) rates to epoetin alfa (EPO) alone or in combination versus non-erythropoiesis-stimulating agents (non-ESAs) in treatment-naïve anemic MDS patients: A meta-analysis approach
Authors: V. M. Moyo, P. Lefebvre, F. Vekeman, M. S. Duh, B. Yektashenas, S. Mundle
Journal: Journal of Clinical Oncology (2008)

7094 Background: EPO+G/GM-CSF has been associated with higher ER rates vs EPO alone. Several non-ESAs have also been studied as single agents or in combination without growth factor. This meta-analysis compares ER rates achieved with EPO either as a single agent or in combination with G/GM-CSF or other agents vs non-ESA therapies (including thalidomide, azacytidine, all-trans retinoic acid, As2O3, etc). Methods: Data extraction was performed on studies from PubMed, ASCO/ASH proceedings in MDS pts treated with EPO±G/GM-CSF or other non-ESAs (search cutoff date 9/30/07). To allow cross comparison, only studies using IWG or IWG-like ER criteria and treatment-naïve pts were selected. Pooled estimates of ER rates were calculated using random-effect (R- E) meta-analysis methods and results were stratified by: (i)EPO monotherapy (monotx), (ii)EPO+G/GM-CSF, (iii)EPO+non-ESAs, (iv)Non-ESA monotx, and (v)Non-ESA combinations. Results: Of 790 studies identified, 35 were included. Most pts (>59%) had RA/RARS, except pts receiving other non-ESAs in combination (45%). EPO monotx studies had lower transfusion dependency rates at baseline vs studies using EPO combinations or Non-ESAs. EPO monotx studies had comparable ER rates to studies using EPO+G/GM-CSF (p=.371) or EPO+Non- ESAs (p=.642). However, EPO monotx studies had higher ER rates vs Non-ESA studies whether monotx (p=.001) or combination regimens were used (p<.001). Higher ER rates were also observed for studies using EPO+G/GM-CSF or EPO+Non-ESAs vs studies using only Non-ESAs in monotx or combination regimens. Conclusions: These results suggest that, with the exception of lenalidomide in del 5q pts, for appropriately selected treatment-naïve pts, currently available non-ESA therapies yield lower ER rates vs EPO monotx or EPO combination regimens. The potential benefit of adding non-ESAs to EPO should be evaluated in randomized, clinical trials. Study Group EPO Monotherapy EPO+G/GM-CSF EPO+Non-ESAs Non-ESAs Monotherapy Non-ESA Combination Regimens No. Studies 9 6 4 11 5 No. Evaluable pts 589 152 108 413 91 Overall ER R-E %s (95%CI) 57.6 (45–70) 50.7 (42–59) 62.9 (44–81) 30.9 (21–41) 25.3 (17–34) Crude %s (95%CI) 53.0 (49–57) 50.7 (43–59) 64.8 (56–74) 33.2 (29–38) 26.4 (17–35) Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Ortho Biotech Ortho Biotech Ortho Biotech
Shock treatment, brain damage, and memory loss: a neurological perspective
Authors: J Friedberg
Journal: American Journal of Psychiatry (1977)

The author reviews reports of neuropathology resulting from electroconvulsive therapy in experimental animals and humans. Although findings of petechial hemorrhage, gliosis, and neuronal loss were well established in the decade following the introduction of ECT, they have been generally ignored since then. ECT produces characteristic EEG changes and severe retrograde amnesia, as well as other more subtle effects on memory and learning. The author concludes that ECT results in brain disease and questions whether doctors should offer brain damage to their patients.