tbuckley/cabot-search huggingface dataset:
Abstract 4512: Is There an Intravascular Ultrasound Luminal Area Threshold That Correlates With Fractional Flow Reserve in Intermediate Coronary Artery Stenosis?
Authors: Itsik Ben-Dor, Rebecca Torguson, Yanlin Li, Gabriel Maluenda, Anh.B Bui, Asmir Syed, Sara Collins, Cedric Delhaye, Kohei Wakabayashi, Kimberly Kaneshige, Zhenyi Xue, Lowell Satller, William O. Suddath, Kenneth Kent, Augusto Pichard, Ron Waksman
Journal: Circulation (2009)

Background : Decision making in pts with intermediate coronary stenosis is still debated. Deferring intervention based on IVUS guidance of MLA ≥4 mm2 or FFR >0.8 is correlated with a low event rate.

Aim: To determine the cutoff MLA determined by IVUS that predicts physiological significance of FFR <0.8 in intermediate coronary stenosis.

Methods: The analysis included 69 intermediate lesions (64 pts) in a vessel diameter >2.5 mm. These lesions were evaluated by FFR and IVUS. Cutoff of positive FFR for ischemia was <0.8.

Results: The mean age was 63.8±12.3 years; 37 were male (56.9%). The mean FFR value was 0.84±0.1; 18 were <0.8 (30.5%). The mean MLA was 3.5±1.1 mm2 and the mean diameter stenosis by QCA was 47.6±10.5%. The MLD by IVUS was 1.8±0.3 mm and by QCA 1.78±0.5 mm. All 18 ischemic lesions (FFR <0.8) were treated and 7 (13.7%) of the non-ischemic lesions were treated. Regression analysis demonstrated strong correlation between FFR and MLA (r=0.4, p<0.001), as well as between FFR and MLD by IVUS (r=0.37, p=0.006) and by QCA (r=0.3, p=0.01). There was an inverse correlation between FFR and lesion length (r= −0.39, p=0.08). There was no correlation between FFR and diameter stenosis by QCA (r=0.1, p=0.2). ROC curve identified a MLA <3.2 mm2 (sensitivity 87.5%, specificity 78.3%) to be the best cutoff value to fit with a FFR <0.8.

Conclusion: Anatomic parameters of intermediate coronary lesions obtained by IVUS showed a significant correlation to the FFR values, however, the cutoff value of the IVUS parameter of MLA <4 mm2 does not always imply physiological ischemia. Therefore, functional assessment of intermediate lesions should remain the gold standard.



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Arcuate keratotomy to treat corneal astigmatism after cataract surgery
Authors: Tetsuro Oshika, Jun Shimazaki, Fumiaki Yoshitomi, Kohtaro Oki, Isao Sakabe, Seiji Matsuda, Toshihiko Shiwa, Makoto Fukuyama, Yuji Hara
Journal: Ophthalmology (1998)
General practitioners' age may influence management of hypertension
Authors: M. Whitfield, A. Hughes
Journal: BMJ (1995)

thrombolysis.The company has been active in helping to encourage the adoption of fast track systems to ensure that patients are treated as early as possible.Taking thrombolysis out of the hospital and into the community without adequate cardiological support may not, however, be the best way of ensuring that patients receive the earliest and most appropriate treatment.
Physical activity, hormone replacement therapy and breast cancer risk: A meta-analysis of prospective studies.
Authors: Cécile Pizot, Mathieu Boniol, Patrick Mullie, Alice Koechlin, Magali Boniol, Peter Boyle, Philippe Autier
Journal: Journal of Clinical Oncology (2015)

1561 Background: A lower risk of breast cancer among physically active women has been frequently reported, but the risk in women using hormone replacement therapy (HRT) appears to be higher. We quantified the association between physical activity and breast cancer, and we examined the influence that HRT use and other risk factors had on this association. Methods: After a systematic literature search, prospective studies were meta-analysed using random-effect models. As physical activity assessment and reporting of results were heterogeneous across studies, breast cancer risk associated with the highest level of physical activity was compared with the lowest level of physical activity. Dose-response analyses were also conducted with studies reporting physical activity either in hours/week or in hours of metabolic equivalent per week (MET-h/week). Results: The literature search identified 38 independent prospective studies published between 1987 and 2014 that included 4,183,888 women of which 116,304 breast cancer cases. Compared to the lowest level of physical activity, the highest level was associated with a summary relative risk (SRR) of 0.88 (95% CI (0.85, 0.90)) for all breast cancer, 0.89 (0.83, 0.95) for ER+/PR+ breast cancer and 0.80 (0.69, 0.92) for ER-/PR- breast cancer. Risk reductions were not influenced by the type of physical activity (occupational or non-occupational), the place of residence, adiposity, and menopausal status. Risk reductions increased with increasing amounts of physical activity, without threshold effect. In six studies that examined the influence of physical activity according to HRT use, the SRR was 0.78 (95% CI (0.70, 0.87)) in women who never used HRT and 0.97 (95% CI (0.88, 1.07)) in women who ever used HRT, without heterogeneity between studies. A sustained change from being physically inactive to engaging in 4 to 7 hours/week of mainly vigorous physical activity could lead to a 31% (95%CI (22, 40)) risk reduction in women who never used HRT. Conclusions: Increasing physical activity is associated with meaningful reductions in the risk of breast cancer. However in women who ever used HRT, the preventative effect of physical activity seems to be cancelled out.
Abstract 4159: Intracoronary ECG Predicts Microvascular Dysfunction Evaluated by Myocardial Blush Grade and TIMI Myocardial Perfusion Grade in Primary Percutaneous Coronary Intervention
Authors: Dennis T Wong, Gary Y Liew, Raj Das, Michael C Leung, Rishi Puri, Kean H Soon, Georgy Chacko, Matthew I Worthley, Karen S Teo, Stephen G Worthley
Journal: Circulation (2009)

Introduction Despite achieving TIMI 3 flow in treatment of ST elevation myocardial infarction (STEMI) with primary percutaneous coronary intervention (PPCI), microvascular perfusion remains impaire...
Backward versus forward visual masking deficits in schizophrenic patients: centrally, not peripherally, mediated?
Authors: D S Saccuzzo, K S Cadenhead, D L Braff
Journal: American Journal of Psychiatry (1996)

Schizophrenic patients have repeatedly demonstrated the inability to rapidly process information when tasks are timed or the processing load is relatively high. Schizophrenic patients show consistent deficits in the visual backward masking paradigm. In visual backward masking, an informational target stimulus is presented, followed after an interstimulus interval by a masking stimulus that interferes with or interrupts target identification.In order to clarify whether the visual backward masking deficits of schizophrenic patients are indeed central rather than peripheral in origin, the authors compared visual backward masking to psychometrically matched visual forward masking performance in 35 normal comparison subjects and then 35 schizophrenic patients. In visual forward masking, the mask precedes the target, and visual forward masking mechanisms are felt to be more peripheral (retinal) than are visual backward masking mechanisms.For psychometrically matched forward and backward masking tasks, the schizophrenic patients had a selective and differential deficit in the backward masking condition.These results support the interpretation that the observed visual backward masking deficits of schizophrenic patients are centrally mediated.
One-Stop Hybrid Coronary Revascularization Versus Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention for the Treatment of Multivessel Coronary Artery Disease
Authors: Liuzhong Shen, Shengshou Hu, Haoran Wang, Hui Xiong, Zhe Zheng, Lihuan Li, Bo Xu, Hongbing Yan, Runlin Gao
Journal: Journal of the American College of Cardiology (2013)
EARLY RESULTS OF PROLONGED STREPTOMYCINPAS TREATMENT OF PULMONARY TUBERCULOSIS
Authors: R S MITCHELL
Journal: Annals of Internal Medicine (1954)

Article1 August 1954EARLY RESULTS OF PROLONGED STREPTOMYCINPAS TREATMENT OF PULMONARY TUBERCULOSISROGER S. MITCHELL, M.D., F.A.C.P.ROGER S. MITCHELL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-2-282 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDESCRIPTION OF STUDYThis is a progress report1 on all 331 patients at Trudeau Sanatorium who were given combined streptomycin-para-aminosalicylic acid (PAS) therapy for four months or more, between March, 1949, and January, 1954. Treatment was started in the last case in June, 1953; 68 patients were still receiving streptomycin-PAS in January, 1954. Most of the patients finished treatment in the charge of their private physicians after discharge. Contact has been maintained in 98 per cent of the cases.Background features were as follows: The socio-economic status of the patients was well above average. The extent of disease was minimal...Bibliography1. MitchellMeadeSteenken RSGMW: Analysis of failures of prolonged streptomycin-PAS treatment of pulmonary tuberculosis, Transactions 12th Conference Chemotherapy Tuberculosis, VA, Army, Navy, Atlanta, Ga., Feb., 1953, p. 92. Google Scholar2. Tucker WB: Comparison of therapeutic effects of randomized chemotherapeutic regimens employed in the treatment of pulmonary tuberculosis, Transactions 10th Conference Chemotherapy Tuberculosis, VA, Army, Navy, Atlanta, Ga., Jan., 1951, p. 42. Google Scholar3. BrinkmanMitchell GLRS: The use of pneumoperitoneum during prolonged streptomycin-PAS treatment of pulmonary tuberculosis, Am. Rev. Tuberc. 69: 963, 1954. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Trudeau, N. Y.*Received for publication February 26, 1954.From Trudeau-Saranac Institute, Trudeau, N. Y. This study was made possible by a grant-in-aid from the Committee on Medical Research of the American Trudeau Society, Medical Section of the National Tuberculosis Association.Presented in part at the V. A., Army, Navy Conference on Chemotherapy of Tuberculosis, February 8-11, 1954, St. Louis, Missouri. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE IMPORTANCE OF LABORATORY SUSCEPTIBILITY TESTING IN TUBERCULOSISClinical Implications of Isoniazid Blood Levels in Pulmonary TuberculosisPresent-day management of tuberculosisDomiciliary treatment of pulmonary tuberculosisPULMONARY RESECTION IN ACTIVE CAVITARY (OPEN-POSITIVE) TUBERCULOSISRelapse after pulmonary resection during prolonged streptomycin-para-aminosalicylic acid treatment of pulmonary tuberculosisHome management of pulmonary tuberculosis and other formsTuberculosis 1 August 1954Volume 41, Issue 2Page: 282-293KeywordsChemotherapyPatientsPeriodic acid Schiff ePublished: 1 December 2008 Issue Published: 1 August 1954 PDF downloadLoading ...
Privacy Rules for DNA Databanks
Authors: George J. Annas
Journal: JAMA (1993)

In privacy terms, genetic information is like medical information. But the information contained in the DNA molecule itself is more sensitive because it contains an individual's probabilistic "future diary," is written in a code that has only partially been broken, and contains information about an individual's parents, siblings, and children. Current rules for protecting the privacy of medical information cannot protect either genetic information or identifiable DNA samples stored in DNA databanks. A review of the legal and public policy rationales for protecting genetic privacy suggests that specific enforceable privacy rules for DNA databanks are needed. Four preliminary rules are proposed to govern the creation of DNA databanks, the collection of DNA samples for storage, limits on the use of information derived from the samples, and continuing obligations to those whose DNA samples are in the databanks. (<i>JAMA</i>. 1993;270:2346-2350)
Hypersomnia in bipolar depression: a comparison with narcolepsy using the multiple sleep latency test
Authors: E A Nofzinger, M E Thase, C F Reynolds, J M Himmelhoch, A Mallinger, P Houck, D J Kupfer
Journal: American Journal of Psychiatry (1991)

This study characterized objectively the hypersomnia frequently seen in the depressed phase of bipolar affective disorder. On the basis of previous work in sleep and affective disorders, it has been hypothesized that the hypersomnia is related to greater REM sleep. This hypothesis was tested by using a multiple sleep latency test to compare bipolar affective disorder with narcolepsy, a well-defined primary sleep disorder associated with known REM sleep dysfunction.Twenty-five bipolar depressed patients were selected on the basis of complaints of hypersomnia. They underwent 2 nights of polysomnography followed by a multiple sleep latency test. Data on their nocturnal sleep and daytime naps were compared with similar data on 23 nondepressed narcoleptic patients referred for sleep evaluation.Despite their complaints of hypersomnia, no abnormalities were noted for the bipolar group in the results from the multiple sleep latency test. Contrary to the working hypothesis, REM sleep was notably absent during daytime naps in the depressed patients, in marked contrast to the findings for the narcoleptic group.The complaint of sleepiness in the hypersomnic bipolar depressed patient appears to be related to the lack of interest, withdrawal, decreased energy, or psychomotor retardation inherent in the anergic depressed condition, rather than an increase in true sleep propensity or REM sleep propensity.
Abstract 12083: Lymphatic Vasculature Mediates Cardiac Progenitor Cell Trafficking After Myocardial Infarction
Authors: Maria Cimini, Luca Troncone, Antonio Di Rocco, Sergio Signore, Antonio Cannata, Piero Anversa, Marcello Rota, Annarosa leri, Polina Goichberg
Journal: Circulation (2014)

Myocardial infarction (MI) and post-MI heart failure are major causes of morbidity and mortality. Cardiac progenitor cells (CPC) regenerate injured myocardium, due to their ability to migrate and engraft in the wounded area. Yet, the mechanisms governing CPC trafficking in the diseased myocardium are largely unknown. We examined a hitherto unaddressed role of cardiac lymphatic microvessels (LMV) in CPC mobilization to the site of infarction. We detected that in acute and chronic MI, mouse CPC accumulated in the infarct border zone in proximity of LMV and traversed their wall. We showed that human CPC actively intravasated into the lumen of three-dimensional LMV formed by human lymphatic endothelial cells (LEC) in vitro. The binding of CPC to LEC was hindered in the presence of N-cadherin inhibitory peptide or E-selectin neutralizing antibody. CPC displayed unique pattern of interactions with LEC. Specifically, the propensity of CPC to adhere to LEC at basal conditions and after pre-stimulation with an inflammatory mediator TNFα was higher comparing to human cardiac microvascular endothelial cells (CMEC). Trans-migration of CPC through LEC but not CMEC monolayer was enhanced following treatment with TNFα. Interference with the SDF-1/CXCR4 pathway diminished CPC intravasation via LEC but did not affect the CPC ability to traverse CMEC. Intriguingly, we found that the bioactive lipid S1P, secreted by endothelial cells, had a significant impact on CPC migration. S1P binds to 5 different S1P receptors (S1P1-5). We established that the expression of S1P3 was enriched in CPC. Although exposure to S1P mitigated CPC motility, an S1P3-selective agonist evoked strong chemotaxis of CPC, whereas down-regulation of S1P3 blocked CPC translocation. Accordingly, CPC activation with S1P3 agonist reduced their contacts with the extracellular matrix, while S1P ligand induced the organization of adhesion complexes containing β1-integrin subunit. The direct role of S1P3 in CPC trafficking in vivo is supported by our observations that S1P3 expression was increased in the cardiac cells associated with LMV after MI. In conclusion, we provide evidence that specific interactions with LMV may promote CPC trafficking in the infarcted heart facilitating myocardial repair.
One-year experience of pulmonology triage in a tertiary service
Authors: Pedro Paulo Ayres, Anna Miethke-Morais, Luis Felipe Prada, Regina Maria Carvalho-Pinto, Carlos Roberto Carvalho
Journal: European Respiratory Journal (2014)

Introduction: Our hospital is a referral service to the city of Sao Paulo and its metropolitan area, serving as a tertiary center for a population of about 19 million inhabitants. Pulmonologists are frequently requested to evaluate other clinics´ outpatients about respiratory complaints, and the first appointment used to take at least 3 months, which was de average time for an available schedule. During the past year, a pulmonology triage was implemented.  Methods: Pulmonologists evaluated referred patients on the same day they showed-up with the solicitation form. After a consultation directed to respiratory issues, it was decided about the need of any further investigation or follow up. Data were collect during each evaluation, about patient (gender, age), referral (specialties and motive) and outcome (need or not of further pulmonology follow up). A descriptive analysis was performed.  Results: 1349 patients were evaluated (790/58,6% female) from 02/01/2013 to 01/31/2014. The median age was 60 years. They were more often referred from non-surgical specialties (780/57,8%), and cardiologist contributed with 329 (24,4%) referrals. The main motives were obstructive pulmonary diseases (358/26,6%), dyspnea (238/17,7%) and pulmonary nodules (92/6,8%). Further pulmonologist consultation was necessary for 874(64,8%) patients.  Discussion: This strategy allowed the first appointment to be much faster, helping to give the proper care to more severe cases and to redirect less complex cases to other units of the healthcare system. After this one-year experience we are aware of the main referral motives, which will allow us to establish institutional protocols to help the case conduction to be more efficient and cost-effective.
Abstract 986: Hematomas of at Least 5 Cm and Outcomes in Patients Undergoing Elective Percutaneous Coronary Intervention: Insights From The STEEPLE Trial
Authors: Harvey White, Gilles Montalescot, Richard Gallo, Steven Steinhubl
Journal: Circulation (2008)

Background: In patients undergoing percutaneous coronary intervention (PCI), bleeding has a significant impact on outcomes including 1-year mortality. There is no uniform definition of bleeding and hematomas ≥ 5 cm at the femoral puncture are considered major bleeding events in some trials. In the STEEPLE trial groin hematomas ≥ 5 cm (excluding retroperitoneal bleeds) were classified as minor bleeds. This subanalysis of the STEEPLE trial assessed the impact of hematomas on patient outcomes and 1-year mortality. Methods: In STEEPLE, 3528 patients undergoing elective PCI received intravenous enoxaparin (enox; 0.5 or 0.75 mg/kg) or unfractionated heparin (UFH). Bleeding sites and size of haematomas were collected. The 30-day outcomes and 1-year mortality of patients with a hematoma ≥ 5 cm were compared to outcomes in patients with no major or minor bleeding. Results: Data on hematomas were available for 3342 patients. Of these, 103 patients (29, 33, 41 in enox 0.5, 0.75 and UFH groups, respectively) had a hematoma ≥ 5 cm; none required transfusion. The 30-day mortality rate, non-fatal myocardial infarction (MI), or urgent target-vessel revascularization (UTVR) were similar between patients with a hematoma ≥ 5 cm and those with no bleeding. All-cause mortality was similar in both groups (Table ). Conclusion: The presence of hematomas ≥ 5 cm had no effect on the 30-day ischemic outcomes and 1-year mortality in patients undergoing elective PCI in the STEEPLE trial. Beyond patient discomfort, hematomas ≥ 5 cm were not associated with need for transfusions, and had no effect on prognosis in this analysis. It remains to be determined how to use them in bleeding classifications.
Predictors for Functionally Significant In-Stent Restenosis
Authors: Soo-Jin Kang, Young-Rak Cho, Gyung-Min Park, Jung-Min Ahn, Seung-Bong Han, Jong-Young Lee, Won-Jang Kim, Duk-Woo Park, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Gary S. Mintz, Seung-Jung Park
Journal: JACC. Cardiovascular imaging (2013)
Erratum: Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice
Authors: K Hartmann, A Illing, F Leithäuser, A Baisantry, L Quintanilla-Martinez, K L Rudolph
Journal: Leukemia (2017)

Correction to: Leukemia (2016) 30, 749–753; doi:10.1038/leu.2015.173; published online 31 July 2015 Following the publication of this article the authors noted that the article was lacking the information on n-numbers for some of the panels of the figures. The description of the results section is specified for the following information on n-numbers of mice: The western blots in Figure 1D and Supplementary Figure 1F were conducted as biological replicates (testis and thymus) using pools of mice of the indicated genotypes (n=6 mice per genotype for thymus, n=4 mice per genotype for testis).
Abstract 3249: Late Endothelial Function of Bilateral Internal Thoracic Arteries Used as a Y-graft Configuration
Authors: David Glineur, Olivier Gurne, Sophia Djaoudi, Joelle Kefer, Nadia Debbas, Jean Renkin, Philippe Noihomme, Gebrine El Khoury, Claude Hanet
Journal: Circulation (2007)

The manner in which a blood vessel is harvested for use as a coronary graft may be important in maintaining a viable and functional endothelial lining. Internal thoracic arteries (ITA), when used as a Y-graft configuration are characterized by the connection of a pedicled left ITA with preserved innervation and lymphatics and of a free skeletonized right ITA. To determine whether endothelial function differs between left and right ITA segments in a Y-graft configuration, 11 patients were studied 3 years after surgery. The endothelial-dependent vasodilator substance P was selectively infused (1.4 up to 22.4 pmol/min in doubling dose increments) in the ostium of ITA Y-grafts. A maximal endothelium-independent vasodilatory response was obtained by intragraft infusion of 2 mg isosorbide dinitrate (ISDN). Biplane angiograms obtained at 3 minutes intervals using an automated contrast injection system with fixed pre-set volume and pressure parameters were analyzed off-line using a quantitative analysis system (CAAS, Pie Medical). A similar dose-dependent vasodilatory response to substance P was observed in the left and in the right ITA (figure ). No difference in maximal endothelium-dependent response to substance P (7.4±4.3% in left ITA and 8.1 ± 5.3% in right ITA) or in maximal endothelium-independent response to ISDN (12.2 ± 4.4% in left ITA and 10.6 ± 8.1% in right ITA) was observed. In conclusion, the endothelial function and the vasodilator reserve of the two branches of a Y-graft ITA configuration appear similar 3 years after bypass surgery. This suggests that the preservation of the ITA pedicle does not significantly affect basal vasomotor tone or long-term endothelial function.
GMC may not be entitled to conclude that assault occurred
Authors: J K Mason, R A M. Smith
Journal: BMJ (1995)

EDITOR,—The finding by the General Medical Council's professional conduct committee that the anaesthetist in the case discussed by John Mitchell and others was guilty of serious professional misconduct raises serious issues.1 The merits or otherwise of the finding are one thing; more serious is the fact that the committee seemed to conclude that, in inserting a suppository without specific consent, the doctor …