tbuckley/cabot-search huggingface dataset:
Outcomes of Endoscopic Submucosal Dissection for High-Risk Colorectal Colitis-Associated Neoplasia in Inflammatory Bowel Disease
Authors: Roberta Maselli, Roberto de Sire, Federico Barbaro, Paolo Cecinato, Gianluca Andrisani, Erik Rosa Rizzotto, Sandro Sferrazza, giancarla fiori, Francesco Azzolini, Francesco Pugliese, Antonio Facciorusso, Marco Spadaccini, Antonio Capogreco, Davide Massimi, Ludovico Alfarone, Michele Francesco Chiappetta, Alessandro Gubbiotti, Maddalena Menini, Kareem Khalaf, Romano Sassatelli, Francesco Maria Di Matteo, Cristiano Spada, Cesare Hassan, Alessandro Repici, Alessandro Armuzzi
Journal: Endoscopy (2025)

Introduction: Inflammatory bowel disease (IBD) patients have an increased risk of developing colorectal cancer. High-risk colorectal colitis-associated neoplasia (HR-CAN) can be difficult to treat using traditional endoscopic resection methods. Aim of the study is to evaluate the outcomes of endoscopic submucosal dissection (ESD) on IBD patients with HR-CANs. Methods: In this retrospective multicenter study, we consecutively included IBD patients referred to expert Italian endoscopy centers who underwent ESD or hybrid-ESD (hESD) for HR-CANs. Main outcomes were the rate of en-bloc, R0, curative resections, adverse events (AEs), the rate of local recurrence, metachronous lesions, and post-resection surgery. Kaplan-Meier method was used to analyze survival curves. Risk factors associated to main outcomes were investigated by univariable analysis. Results: Ninety-one colonic IBD patients (83.4% ulcerative colitis, disease duration of 15.3 ± 8.7 years) with 96 HR-CANs (53.1% high-grade dysplasia/adenocarcinoma, size 34.8 mm ± 16.2 mm) were included. ESD and hESD were performed in 82.3% and 17.7% of cases. En-bloc, R0, and curative resections were achieved in 95.9% (95% CI 0.958; 0.896-0.988), 85.4% (95% CI 0.854; 0.767-0.917), and 83.3% (95% CI 0.833; 0.743-0.901) of cases. AEs occurred in 12.5% (95% CI 0.125; 0.066-0.208) of cases, which were all conservatively managed. After a mean follow-up of 23.4 ± 16.1 months, local recurrence and metachronous lesions occurred each in 3.1% (95% CI 0.031; 0.006-0.088) of cases. Post-resection surgery was required in 11.5% (95%CI 0.114; 0.058-0.195) of cases. Conclusions: ESD of HR-CANs shows favorable outcomes on the medium and long-term course in IBD patients.
Life expectancy by county and educational attainment in the USA, 2000–19: an observational analysis
Authors: Dillon O Sylte, Mathew M Baumann, Yekaterina O Kelly, Parkes Kendrick, Omnia M M Ali, Kelly Compton, Chris A Schmidt, Ethan Kahn, Zhuochen Li, Wichada La Motte-Kerr, Farah Daoud, Emmanuela Gakidou, Simon I Hay, Paula D Strassle, George A Mensah, David M Murray, Elizabeth Arias, Stephanie M George, Eliseo J Pérez-Stable, Christopher J L Murray, Ali H Mokdad, Laura Dwyer-Lindgren
Journal: The Lancet Public Health (2025)
Coronary CT angiography-guided management of patients with stable chest pain: 10-year outcomes from the SCOT-HEART randomised controlled trial in Scotland
Authors: Michelle C Williams, Ryan Wereski, Christopher Tuck, Philip D Adamson, Anoop S V Shah, Edwin J R van Beek, Giles Roditi, Colin Berry, Nicholas Boon, Marcus Flather, Steff Lewis, John Norrie, Adam D Timmis, Nicholas L Mills, Marc R Dweck, David E Newby
Journal: The Lancet (2025)
Stopping of adalimumab in juvenile idiopathic arthritis-associated uveitis (ADJUST): a multicentre, double-masked, randomised controlled trial
Authors: Nisha R Acharya, Athimalaipet V Ramanan, Alison B Coyne, Kathryn L Dudum, Elia M Rubio, Sydney M Woods, Catherine M Guly, Elena Moraitis, Harry J D Petrushkin, Kate Armon, Narman Puvanachandra, Jessy T Choi, Daniel P Hawley, Benjamin F Arnold
Journal: The Lancet (2025)
Antiviral activity of tecovirimat against monkeypox virus clades 1a, 1b, 2a, and 2b
Authors: Jeanne Postal, Florence Guivel-Benhassine, Françoise Porrot, Quentin Grassin, Jack M Crook, Riccardo Vernuccio, Valérie Caro, Jessica Vanhomwegen, Pablo Guardado-Calvo, Etienne Simon-Lorière, Laurent Dacheux, Jean-Claude Manuguerra, Olivier Schwartz
Journal: The Lancet Infectious Diseases (2025)
Intense FAP Expression of Ovarian Metastatic Breast Cancer Detected by [68Ga]RTX-1363 PET/CT
Authors: Lisa Glantschnig, Nic G. Reitsam, Malte Kircher, Diana Segmiller, Constantin Lapa, Alexander Dierks
Journal: Clinical Nuclear Medicine (2025)

Abstract PET/CT targeting fibroblast activation protein α (FAP) in cancer-associated fibroblasts shows promise in theranostics. Here, we report the case of a 31-year-old woman with hormone receptor–positive/human epidermal growth factor receptor 2–negative breast cancer who presented with rising CA15-3 for further diagnostic workup. Whereas [ 18 F]FDG PET/CT was unremarkable, novel [ 68 Ga]RTX-1363 PET/CT revealed intense tracer accumulation in thoracoabdominal lymph nodes and both ovaries. Follow-up imaging confirmed tumor progression, and diagnostic laparoscopy verified metastatic disease in the ovaries with high FAP expression in the tumor stroma. This case underscores the superior sensitivity of [ 68 Ga]RTX-1363 PET/CT over [ 18 F]FDG PET/CT, enhancing breast cancer diagnostic and therapeutic strategies.
WT1-mRNA dendritic cell vaccination of patients with glioblastoma multiforme, malignant pleural mesothelioma, metastatic breast cancer, and other solid tumors: type 1 T-lymphocyte responses are associated with clinical outcome
Authors: Zwi N. Berneman, Maxime De Laere, Paul Germonpré, Manon T. Huizing, Yannick Willemen, Eva Lion, Hans De Reu, Jolien Van den Bossche, Jan Van den Brande, Pol Specenier, Sevilay Altintas, Peter A. van Dam, Nathalie Cools, Griet Nijs, Barbara Stein, Kim Caluwaerts, Annemiek Snoeckx, Bart Op de Beeck, Kirsten Saevels, Lynn Rutsaert, Irma Vandenbosch, Gizem Oner, Martin Lammens, Pierre Van Damme, Sian Llewellyn-Lacey, David A. Price, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama, Marie M. Couttenye, Ann L. Van de Velde, Viggo F. Van Tendeloo, Marc Peeters, Sébastien Anguille, Evelien L.J.M. Smits
Journal: Journal of Hematology & Oncology (2025)

Cell therapies, including tumor antigen-loaded dendritic cells used as therapeutic cancer vaccines, offer treatment options for patients with malignancies. We evaluated the feasibility, safety, immunogenicity, and clinical activity of adjuvant vaccination with Wilms' tumor protein (WT1) mRNA-electroporated autologous dendritic cells (WT1-mRNA/DC) in a single-arm phase I/II clinical study of patients with advanced solid tumors receiving standard therapy. Disease status and immune reactivity were evaluated after 8 weeks and 6 months. WT1-mRNA/DC vaccination was feasible in all patients, except one. Vaccination was well tolerated without evidence of systemic toxicity. The disease control rate and overall response rate among a total of 39 evaluable patients were 74.4% and 12.8%, respectively. Median overall survival (OS) was 43.7 months among 13 patients with glioblastoma multiforme, 41.9 months among 12 patients with metastatic breast cancer, and 48.8 months among 10 patients with malignant pleural mesothelioma, comparing favourably with historical controls reported in the literature. OS was longer in patients with stable disease at 8 weeks and disease control at 6 months versus patients without disease control at either time point. Disease control and higher OS were associated with antigen-specific type 1 CD4+ and/or CD8+ T-lymphocyte responses, mainly induced by WT1-mRNA/DC vaccination. Antigen-nonspecific type 2 CD8+ T-cell responses were common before WT1-mRNA/DC vaccination but did not show any association with clinical outcome. Collectively, these data indicate that WT1-mRNA/DC vaccination is feasible, safe, and immunogenic and shows clinical activity in patients with advanced solid tumors, suggesting that it has the potential to help improve their survival.
Circuit Modules for Flexible Locomotion
Authors: Laurence Picton, Irene Pallucchi, Pierre Fontanel, Maria Bertuzzi, Jianren Song, Abdeljabbar El Manira
Journal: Annual Review of Neuroscience (2025)

Locomotion, like all behaviors, possesses an inherent flexibility that allows for the scaling of movement kinematic features, such as speed and vigor, in response to an ever-changing external world and internal drives. This flexibility is embedded in the organization of the spinal locomotor circuits, which encode and decode commands from the brainstem and proprioceptive feedback. This review highlights our current understanding of the modular organization of these locomotor circuits and how this modularity endows them with intrinsic mechanisms to adjust speed and vigor, thereby contributing to the flexibility of locomotor movements.
Re: Massimiliano Creta, Giorgio I. Russo, Naeem Bhojani, et al. Bladder Outlet Obstruction Relief and Symptom Improvement Following Medical and Surgical Therapies for Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia: A Systematic Review. Eur Urol 2024;86:315–26
Authors: Yu-Hsiang Lin, Kou-Jen Lin, Horng-Heng Juang
Journal: European Urology (2025)
The Brussels consensus for non-invasive ICP monitoring when invasive systems are not available in the care of TBI patients (the B-ICONIC consensus, recommendations, and management algorithm)
Authors: Chiara Robba, Edoardo Picetti, Sebastián Vásquez-García, Yasser B Abulhasan, Amelia Ain, Amos O Adeleye, Marcel Aries, Sérgio Brasil, Rafael Badenes, Alessandro Bertuccio, Pierre Bouzat, Luis Bustamante, Lorenzo Calabro', Hassane Njimi, Danilo Cardim, Giuseppe Citerio, Marek Czosnyka, Thomas Geeraerts, Daniel A Godoy, Mohammad I Hirzallah, Bhagavatula Indira Devi, Manuel Jibaja, Piergiorgio Lochner, Julio C Mijangos Méndez, Geert Meyfroidt, Thangaraj Munusamy, Juan Pinedo Portilla, Hemanshu Prabhakar, Frank Rasulo, Diana M Sánchez Parra, Aarti Sarwal, Gentle S Shrestha, Dhaval P Shukla, Gene Sung, Abenezer Tirsit, Franly Vásquez, Walter Videtta, Yu Lin Wang, Wellingson S Paiva, Fabio Silvio Taccone, Andres M Rubiano
Journal: Intensive Care Medicine (2025)
Reply to Yu-Hsiang Lin, Kou-Jen Lin, and Horng-Heng Juang’s Letter to the Editor re: Massimiliano Creta, Giorgio I. Russo, Naeem Bhojani, et al. Bladder Outlet Obstruction Relief and Symptom Improvement Following Medical and Surgical Therapies for Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia: A Systematic Review. Eur Urol 2024;86:315–26
Authors: Massimiliano Creta, Jean-Nicolas Cornu, Ferdinando Fusco
Journal: European Urology (2025)
A Call for a Neoadjuvant Kidney Cancer Consortium: Lessons Learned from Other Cancer Types
Authors: Axel Bex, Michael Jewett, Bryan Lewis, E Jason Abel, Laurence Albiges, Stephanie A Berg, Gennady Bratslavsky, David Braun, James Brugarolas, Toni K Choueiri, Antonio Finelli, Daniel George, Naomi B Haas, A Ari Hakimi, Hans Hammers, Michelle Hirsch, Eric Jonasch, Payal Kapur, W Marston Linehan, Viraj Master, Bradley McGregor, Rana R McKay, Rohit Mehra, Sumantha Pal, Susan Poteat, Thomas B Powles, Sabrina H Rossi, Daniel D Shapiro, Sabina Signoretti, Eric A Singer, Chuck Stravin, Nizar Tannir, Ulka Vaishampayan, Wenxin Xu, Grant D Stewart
Journal: European Urology (2025)
Effect of Normobaric Hypoxia on Invasive Exercise Hemodynamics in Patients with Pulmonary Vascular Disease: A Randomized Controlled Trial
Authors: Mona Lichtblau, Simon R. Schneider, Julian Müller, Meret Bauer, Arcangelo F. Carta, Laura Mayer, Esther I Schwarz, Michael Furian, Stéphanie Saxer, Silvia Ulrich
Journal: American Journal of Respiratory and Critical Care Medicine (2025)

"Effect of Normobaric Hypoxia on Invasive Exercise Hemodynamics in Patients with Pulmonary Vascular Disease: A Randomized Controlled Trial." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Machine Learning Potential for Identifying and Forecasting Complex Environmental Drivers of <i>Vibrio vulnificus</i> Infections in the United States
Authors: Amy Marie Campbell, Jordi Manuel Cabrera-Gumbau, Joaquin Trinanes, Craig Baker-Austin, Jaime Martinez-Urtaza
Journal: Environmental Health Perspectives (2025)

Environmental change in coastal areas can drive marine bacteria and resulting infections, such as those caused by Vibrio vulnificus, with both foodborne and nonfoodborne exposure routes and high mortality. Although ecological drivers of V. vulnificus in the environment have been well-characterized, fewer models have been able to apply this to human infection risk due to limited surveillance. The Cholera and Other Vibrio Illness Surveillance (COVIS) system database has reported V. vulnificus infections in the United States since 1988, offering a unique opportunity to both explore the forecasting capabilities machine learning could provide and to characterize complex environmental drivers of V. vulnificus infections. Machine learning models, in the form of random forest classification models, were trained and refined using the epidemiological data from 2008 to 2018, six environmental variables (sea surface temperature, salinity, chlorophyll a concentration, sea level, land surface temperature, and runoff rate) and categorical encoders to assess our predictive potential to forecast V. vulnificus infections based on environmental data. The highest-performing model, which used balanced classes, had an Area Under the Curve score of 0.984 and a sensitivity of 0.971, highlighting the potential of machine learning to anticipate areas and periods of V. vulnificus risk. A higher false positive rate was found when the model was applied to real-world imbalanced surveillance data, which is pertinent amid modeled underreporting and misdiagnosis ratios of V. vulnificus infections. Further models were also developed to explore multilevel spatial resolution, finding state-specific models can improve specificity and early warning system potential by exclusively using lagged environmental data. The machine learning approach was able to characterize nonlinear and interacting environmental associations driving V. vulnificus infections. This study accentuates the potential of machine learning and robust surveillance for forecasting environmentally associated marine infections, providing future directions for improvements, further application, and operationalization. https://doi.org/10.1289/EHP15593.
Single-Cell Multi-Omics Profiling of Immune Cells Isolated from Atherosclerotic Plaques in Male ApoE Knockout Mice Exposed to Arsenic
Authors: Kiran Makhani, Xiuhui Yang, France Dierick, Nivetha Subramaniam, Natascha Gagnon, Talin Ebrahimian, Stephanie Lehoux, Hao Wu, Jun Ding, Koren K. Mann
Journal: Environmental Health Perspectives (2025)

Millions worldwide are exposed to elevated levels of arsenic that significantly increase their risk of developing atherosclerosis, a pathology primarily driven by immune cells. While the impact of arsenic on immune cell populations in atherosclerotic plaques has been broadly characterized, cellular heterogeneity is a substantial barrier to in-depth examinations of the cellular dynamics for varying immune cell populations. This study aimed to conduct single-cell multi-omics profiling of atherosclerotic plaques in apolipoprotein E knockout (ApoE-/-) mice to elucidate transcriptomic and epigenetic changes in immune cells induced by arsenic exposure. The ApoE-/- mice were fed a high-fat diet and were exposed to either 200 ppb arsenic in drinking water or a tap water control, and single-cell multi-omics profiling was performed on atherosclerotic plaque-resident immune cells. Transcriptomic and epigenetic changes in immune cells were analyzed within the same cell to understand the effects of arsenic exposure. Our data revealed that the transcriptional profile of macrophages from arsenic-exposed mice were significantly different from that of control mice and that differences were subtype specific and associated with cell-cell interaction and cell fates. Additionally, our data suggest that differences in arsenic-mediated changes in chromosome accessibility in arsenic-exposed mice were statistically more likely to be due to factors other than random variation compared to their effects on the transcriptome, revealing markers of arsenic exposure and potential targets for intervention. These findings in mice provide insights into how arsenic exposure impacts immune cell types in atherosclerosis, highlighting the importance of considering cellular heterogeneity in studying such effects. The identification of subtype-specific differences and potential intervention targets underscores the significance of understanding the molecular mechanisms underlying arsenic-induced atherosclerosis. Further research is warranted to validate these findings and explore therapeutic interventions targeting immune cell dysfunction in arsenic-exposed individuals. https://doi.org/10.1289/EHP14285.
Targeting LMO2-induced autocrine FLT3 signaling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia
Authors: Cedric S. Tremblay, Jesslyn Saw, Feng Yan, Jacqueline A. Boyle, Ovini Amarasinghe, Shokoufeh Abdollahi, Anh N. Q. Vo, Benjamin J. Shields, Chelsea Mayoh, Hannah McCalmont, Kathryn Evans, Anna Steiner, Kevin Parsons, Matthew P. McCormack, David R. Powell, Nicholas C. Wong, Stephen M. Jane, Richard B. Lock, David J. Curtis
Journal: Leukemia (2025)

Abstract Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is an immature subtype of T-cell acute lymphoblastic leukemia (T-ALL) commonly show deregulation of the LMO2-LYL1 stem cell transcription factors, activating mutations of cytokine receptor signaling, and poor early response to intensive chemotherapy. Previously, studies of the Lmo2 transgenic mouse model of ETP-ALL identified a population of stem-like T-cell progenitors with long-term self-renewal capacity and intrinsic chemotherapy resistance linked to cellular quiescence. Here, analyses of Lmo2 transgenic mice, patient-derived xenografts, and single-cell RNA-sequencing data from primary ETP-ALL identified a rare subpopulation of leukemic stem cells expressing high levels of the cytokine receptor FLT3. Despite a highly proliferative state, these FLT3-overexpressing cells had long-term self-renewal capacity and almost complete resistance to chemotherapy. Chromatin immunoprecipitation and assay for transposase-accessible chromatin sequencing demonstrated FLT3 and its ligand may be direct targets of the LMO2 stem-cell complex. Media conditioned by Lmo2 transgenic thymocytes revealed an autocrine FLT3-dependent signaling loop that could be targeted by the FLT3 inhibitor gilteritinib. Consequently, gilteritinib impaired in vivo growth of ETP-ALL and improved the sensitivity to chemotherapy. Furthermore, gilteritinib enhanced response to the BCL2 inhibitor venetoclax, which may enable “chemo-free” treatment of ETP-ALL. Together, these data provide a cellular and molecular explanation for enhanced cytokine signaling in LMO2 -driven ETP-ALL beyond activating mutations and a rationale for clinical trials of FLT3 inhibitors in ETP-ALL.
A novel anti-ischemic stroke candidate drug AAPB with dual effects of neuroprotection and cerebral blood flow improvement
Authors: Jianbing Wu, Duorui Ji, Weijie Jiao, Jian Jia, Jiayi Zhu, Taijun Hang, Xijing Chen, Yang Ding, Yuwen Xu, Xinglong Chang, Liang Li, Qiu Liu, Yumei Cao, Yan Zhong, Xia Sun, Qingming Guo, Tuanjie Wang, Zhenzhong Wang, Ya Ling, Wei Xiao, Zhangjian Huang, Yihua Zhang
Journal: Acta Pharmaceutica Sinica B (2025)

Ischemic stroke (IS) is a globally life-threatening disease. Presently, few therapeutic medicines are available for treating IS, and rt-PA is the only drug approved by the US Food and Drug Administration (FDA) in the US. In fact, many agents showing excellent neuroprotection but no blood flow-improving activity in animals have not achieved ideal clinical efficacy, while thrombolytic drugs only improving blood flow without neuroprotection have limited their wider application. To address these challenges and meet the huge unmet clinical need, we have designed and identified a novel compound AAPB with dual effects of neuroprotection and cerebral blood flow improvement. AAPB significantly reduced cerebral infarction and neural function deficit in tMCAO rats, pMCAO rats, and IS rhesus monkeys, as well as displayed exceptional safety profiles and excellent pharmacokinetic properties in rats and dogs. AAPB has now entered phase I of clinical trials fighting IS in China.
Multimodal strategies for the implementation of infection prevention and control (IPC) interventions - update of a systematic review for the WHO guidelines on core components of IPC programmes at the facility level
Authors: Ashlesha Sonpar, Chandra Omar Hundal, Joan E E Totté, Jiancong Wang, Sabine D Klein, Anthony Twyman, Benedetta Allegranzi, Walter Zingg
Journal: Clinical Microbiology and Infection (2025)
Measures and Models of Brain-Heart Interactions
Authors: Diego Candia-Rivera, Luca Faes, Fabrizio de Vico Fallani, Mario Chavez
Journal: IEEE Reviews in Biomedical Engineering (2025)

Exploring brain-heart interactions within various paradigms, including affective computing, human-computer interfaces, and sensorimotor evaluation, has demonstrated enormous potential in biomarker development and neuroscientific research. A range of techniques, from molecular to behavioral approaches, has been proposed to measure these interactions. Different frameworks use signal processing techniques, from estimating brain responses to individual heartbeats to interactions linking the heart to changes in brain organization. This review provides an overview of the most notable signal processing strategies currently used for measuring and modeling brain-heart interactions. It discusses their usability and highlights the main challenges that need to be addressed for future methodological developments. Current methodologies have deepened our understanding of the impact of physiological disruptions on brain-heart interactions, solidifying it as a biomarker. The vast outlook of these methods could provide tools for disease stratification in neurological and psychiatric disorders. As we tackle new methodological challenges, gaining a more profound understanding of how these interactions operate, we anticipate further insights into the role of peripheral neurons and the environmental input from the rest of the body in shaping brain functioning.
Application-driven validation of posteriors in inverse problems
Authors: Tim J Adler, Jan-Hinrich Nölke, Annika Reinke, Minu Dietlinde Tizabi, Sebastian Gruber, Dasha Trofimova, Lynton Ardizzone, Paul F Jaeger, Florian Buettner, Ullrich Köthe, Lena Maier-Hein
Journal: Medical Image Analysis (2025)
Saliva-acquired pellicle inspired multifunctional gargle with wet adhesion, photodynamic antimicrobial, and In situ remineralization properties for dental caries prevention
Authors: Jiayi Shi, Xuekai Qi, Ying Ran, Qiang Zhou, Yiqin Ding, Lujian Li, Youyun Zeng, Dongchao Qiu, Zhibin Cai, Xiaojun Cai, Yihuai Pan
Journal: Bioactive Materials (2025)
CD9-enriched extracellular vesicles from chemically reprogrammed basal progenitors of salivary glands mitigate salivary gland fibrosis
Authors: Sunyoung Park, Yeo-Jun Yoon, Yongpyo Hong, Jianning Yu, Jae-Min Cho, Ye Jin Jeong, Haeun Yu, Hyorim Jeong, Hyunjin Lee, Seungyeon Hwang, Won-Gun Koh, Ji Yeong Yang, Kyung-A Hyun, Hyo-Il Jung, Jae-Yol Lim
Journal: Bioactive Materials (2025)