tbuckley/cabot-search huggingface dataset:
Author Correction: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
Authors: Jonathan P. Bradfeld, Rachel L. Kember, Anna Ulrich, Zhanna Balkhiyarova, Akram Alyass, Izzuddin M. Aris, Joshua A. Bell, K. Alaine Broadaway, Zhanghua Chen, Jin-Fang Chai, Neil M. Davies, Dietmar Fernandez-Orth, Mariona Bustamante, Ruby Fore, Amitavo Ganguli, Anni Heiskala, Jouke-Jan Hottenga, Carmen Íñiguez, Sayuko Kobes, Jaakko Leinonen, Estelle Lowry, Leo-Pekka Lyytikainen, Anubha Mahajan, Niina Pitkänen, Theresia M. Schnurr, Christian Theil Have, David P. Strachan, Elisabeth Thiering, Suzanne Vogelezang, Kaitlin H. Wade, Carol A. Wang, Andrew Wong, Louise Aas Holm, Alessandra Chesi, Catherine Choong, Miguel Cruz, Paul Elliott, Steve Franks, Christine Frithiof-Bøjsøe, W. James Gauderman, Joseph T. Glessner, Vicente Gilsanz, Kendra Griesman, Robert L. Hanson, Marika Kaakinen, Heidi Kalkwarf, Andrea Kelly, Joseph Kindler, Mika Kähönen, Carla Lanca, Joan Lappe, Nanette R. Lee, Shana McCormack, Frank D. Mentch, Jonathan A. Mitchell, Nina Mononen, Harri Niinikoski, Emily Oken, Katja Pahkala, Xueling Sim, Yik-Ying Teo, Leslie J. Baier, Toos van Beijsterveldt, Linda S. Adair, Dorret I. Boomsma, Eco de Geus, Mònica Guxens, Johan G. Eriksson, Janine F. Felix, Frank D. Gilliland, Torben Hansen, Rebecca Hardy, Marie-France Hivert, Jens-Christian Holm, Vincent W. V. Jaddoe, Marjo-Riitta Järvelin, Terho Lehtimäki, David A. Mackey, David Meyre, Karen L. Mohlke, Juha Mykkänen, Sharon Oberfeld, Craig E. Pennell, John R. B. Perry, Olli Raitakari, Fernando Rivadeneira, Seang-Mei Saw, Sylvain Sebert, John A. Shepherd, Marie Standl, Thorkild I. A. Sørensen, Nicholas J. Timpson, Maties Torrent, Gonneke Willemsen, Elina Hypponen, Chris Power, Mark I. McCarthy, Rachel M. Freathy, Elisabeth Widén, Hakon Hakonarson, Inga Prokopenko, Benjamin F. Voight, Babette S. Zemel, Struan F. A. Grant, Diana L. Cousminer
Journal: Genome biology (2024)
A developmental account of curiosity and creativity
Authors: Julie Vaisarova, Kelsey Lucca
Journal: Behavioral and Brain Sciences (2024)

Abstract Ivancovsky et al.'s Novelty-Seeking Model suggests several mechanisms that might underlie developmental change in creativity and curiosity. We discuss how these implications both do and do not align with extant developmental findings, suggest two further elements that can provide a more complete developmental account, and discuss current methodological barriers to formulating an integrated developmental model of curiosity and creativity.
Distinct neurocognitive pathways underlying creativity: An integrative approach
Authors: Matthijs Baas, Claire E. Stevenson, Corinna Perchtold-Stefan, Bernard A. Nijstad, Carsten K. W. De Dreu
Journal: Behavioral and Brain Sciences (2024)

By examining the shared neuro-cognitive correlates of curiosity and creativity, we better understand the brain basis of creativity. However, by only examining shared components, important neuro-cognitive correlates are overlooked. Here, we argue that any comprehensive brain model of creativity should consider multiple cognitive processes and, alongside the interplay between brain networks, also the neurochemistry and neural oscillations that underly creativity.
The costs of curiosity and creativity: Minimizing the downsides while maximizing the upsides
Authors: Todd B. Kashdan, James C. Kaufman, Patrick E. McKnight
Journal: Behavioral and Brain Sciences (2024)

Abstract The unbridled positivity toward curiosity and creativity may be excessive. Both aid species survival through exploration and advancement. These beneficial effects are well documented. What remains is to understand their optimal levels and contexts for maximal achievement, health, and well-being. Every beneficial element to individuals and groups carries the potential for harm – curiosity and creativity included.
Novelty seeking is neither necessary nor sufficient for curiosity or creativity, instead both curiosity and creativity may reflect an epistemic drive
Authors: Linus Holm, Paul Schrater
Journal: Behavioral and Brain Sciences (2024)

Abstract Novelty is neither necessary nor sufficient to link curiosity and creativity as stated in the target article. We point out the article's logical shortcomings, outline preconditions that may link curiosity and creativity, and suggest that curiosity and creativity may be expressions of a common epistemic drive.
On the dual nature of creativity: Same same but different?
Authors: Mathias Benedek
Journal: Behavioral and Brain Sciences (2024)

Abstract The creativity literature is replete with dualistic constructs, suggesting shared mechanisms but also tempting overinterpretation of their interrelations. An explicit list of relevant concept associations indicates substantial commonality, yet also exposes certain inconsistencies. Dual-process accounts (A and B is relevant) hold promise in resolving discrepancies to the extent that we understand the relative contributions and conditions of A and B.
Question-asking as a mechanism of information seeking
Authors: Tuval Raz, Yoed N. Kenett
Journal: Behavioral and Brain Sciences (2024)

Ivancovsky et al. explore the relationship between curiosity and creativity, by suggesting they align through novelty-seeking mechanisms. We argue that a general mechanism linking both capacities together is question-asking: Curiosity drives question-asking that leads to creative problem solving. Yet, current findings from our lab suggest that question complexity relates to creativity, but not necessarily to curiosity, warranting further investigation.
Novelty seeking might underlie curiosity and the novelty dimension of creativity, but not the usefulness dimension
Authors: Oguz A. Acar, Christoph Fuchs
Journal: Behavioral and Brain Sciences (2024)

We question the perspective that curiosity and creativity stem from a shared novelty-seeking process. We emphasize that creativity has two distinct dimensions: Novelty and usefulness, each involving separate cognitive processes. These dimensions may not necessarily mutually reinforce each other. We contend that a more comprehensive model that encompasses the full scope of the creativity construct is needed.
Dissecting the neuroanatomy of creativity and curiosity: The subdivisions within networks matter
Authors: Rocco Chiou, Francesca M. Branzi, Katya Krieger-Redwood, Elizabeth Jefferies
Journal: Behavioral and Brain Sciences (2024)

Ivancovsky et al. argue that the neurocognitive mechanisms of creativity and curiosity both rely on the interplay among brain networks. Research to date demonstrates that such inter-network dynamics are further complicated by functional fractionation within networks. Investigating how networks subdivide and reconfigure in service of a task offers insights about the precise anatomy that underpins creative and curious behaviour.
The creativity of architects
Authors: Michael A. Arbib
Journal: Behavioral and Brain Sciences (2024)

TA builds on the state of mind (SoM) framework to offer the novelty-seeking model (NSM). The model relates curiosity to creativity but this commentary focuses on creativity: (i) It assesses the SoM + NSM model of creativity-in-the-lab, showing that the focus on semantic networks is inadequate. (ii) It discusses architectural design to sketch ideas for a theory of "big C" creativity.
Is a wandering mind a novelty-seeking mind? The curious case of incubation
Authors: Myrthe Faber, Alwin de Rooij
Journal: Behavioral and Brain Sciences (2024)

The Novelty-Seeking Model can explain incubation's effect on creativity by assuming an adaptive decision threshold. During an impasse, the threshold for novelty becomes too high and biased to previous neural activity, hindering progress. Incubation "resets" this threshold through attentional decoupling, allowing for spontaneous ideas to emerge from subsequent mind wandering or other activities that attract attention, facilitating progress.
Nutrition in the intensive care unit: from the acute phase to beyond
Authors: Angelique M E de Man, Jan Gunst, Annika Reintam Blaser
Journal: Intensive Care Medicine (2024)

Recent randomized controlled trials (RCTs) have shown no benefit but dose-dependent harm by early full nutritional support in critically ill patients. Lack of benefit may be explained by anabolic resistance, suppression of cellular repair processes, and aggravation of hyperglycemia and insulin needs. Also early high amino acid doses did not provide benefit, but instead associated with harm in patients with organ dysfunctions. However, most studies focused on nutritional interventions initiated during the first days after intensive care unit admission. Although the intervention window of some RCTs extended into the post-acute phase of critical illness, no large RCTs studied nutritional interventions initiated beyond the first week. Hence, clear evidence-based guidance on when and how to initiate and advance nutrition is lacking. Prolonged underfeeding will come at a price as there is no validated metabolic monitor that indicates readiness for medical nutrition therapy, and an adequate response to nutrition, which likely varies between patients. Also micronutrient status cannot be assessed reliably, as inflammation can cause redistribution, so that plasma micronutrient concentrations are not necessarily reflective of total body stores. Moreover, high doses of individual micronutrients have not proven beneficial. Accordingly, current evidence provides clear guidance on which nutritional strategies to avoid, but the ideal nutritional regimen for individual patients remains unclear. In this narrative review, we summarize the findings of recent studies, discuss possible mechanisms explaining the results, point out pitfalls in interpretation of RCTs and their effect on clinical practice, and formulate suggestions for future research.
Be curious: Strategic curiosity drives creativity
Authors: Maciej Karwowski, Aleksandra Zielińska
Journal: Behavioral and Brain Sciences (2024)

Abstract Ivancovsky et al. provide a compelling argument for the role of curiosity in creative thinking. We argue that (a) trait-like curiosity is necessary to engage in creative actions and (b) state-like curiosity might be effectively and strategically induced during interventions. Thus, we posit that curiosity works in an agentic and strategic way in strengthening creativity.
Creativity is motivated by novelty. Curiosity is triggered by uncertainty
Authors: Aditya Singh, Kou Murayama
Journal: Behavioral and Brain Sciences (2024)

Although creativity and curiosity can be similarly construed as knowledge-building processes, their underlying motivation is fundamentally different. Specifically, curiosity drives organisms to seek information that reduces uncertainty so that they can make a better prediction about the world. On the contrary, creative processes aim to connect distant pieces of information, maximizing novelty and utility.
An extension of the novelty-seeking model: Considering the plurality of novelty types and their differential interactions with memory
Authors: Anaïs Servais, Christine Bastin
Journal: Behavioral and Brain Sciences (2024)

The novelty-seeking model suggests that curiosity and creativity originate from novelty processes. However, different types of novelty exist, each with distinctive relationships with memory, which potentially influence curiosity and creativity in distinct ways. We thus propose expanding the NSM model to consider these different novelty types and their specific involvement in creativity.
Computational models of intrinsic motivation for curiosity and creativity
Authors: Sophia Becker, Alireza Modirshanechi, Wulfram Gerstner
Journal: Behavioral and Brain Sciences (2024)

Abstract We link Ivancovsky et al.'s novelty-seeking model (NSM) to computational models of intrinsically motivated behavior and learning. We argue that dissociating different forms of curiosity, creativity, and memory based on the involvement of distinct intrinsic motivations (e.g., surprise and novelty) is essential to empirically test the conceptual claims of the NSM.
A shared novelty-seeking basis for creativity and curiosity: Response to the commentators
Authors: Tal Ivancovsky, Shira Baror, Moshe Bar
Journal: Behavioral and Brain Sciences (2024)

In our target article, we proposed that curiosity and creativity are both manifestations of the same novelty-seeking process. We received 29 commentaries from diverse disciplines that add insights to our initial proposal. These commentaries ultimately expanded and supplemented our model. Here we draw attention to five central practical and theoretical issues that were raised by the commentators: (1) The complex construct of novelty and associated concepts; (2) the underlying subsystems and possible mechanisms; (3) the different pathways and subtypes of curiosity and creativity; (4) creativity and curiosity "in the wild"; (5) the possible link(s) between creativity and curiosity.
Impact of metabolic bariatric surgery on outcomes and the 10-year risk of major adverse cardiovascular events during a 7-year period: a retrospective cohort study
Authors: Hsin-Mei Pan, Wei-Jei Lee, Kong-Han Ser, Tien-Chou Soong, Ming-Hsien Lee, Chien-Hua Lin, Kuo-Feng Hsu
Journal: International Journal of Surgery (2024)

Metabolic bariatric surgery offers enduring weight reduction and alleviation of obesity-related comorbidities, including dyslipidemia, diabetes, hypertension, and major adverse cardiovascular events (MACE). Long-term data on one-anastomosis gastric bypass (OAGB) and single-anastomosis duodenal-jejunal bypass with sleeve gastrectomy (SADJB-SG) is lacking, necessitating this investigation.
A shared “optimal-level of arousal”: Seeking basis for creativity and curiosity
Authors: Erik Gustafsson, Paula Ibáñez de Aldecoa, Emily R R Burdett
Journal: Behavioral and Brain Sciences (2024)

Abstract We argue that the phases identified in the novelty-seeking model can be clarified by considering an updated version of the optimal-level of arousal model, which incorporates the “arousal” and “mood changing” potentials of stimuli and contexts. Such a model provides valuable insights into what determines one's state of mind, inter-individual differences, and the rewarding effects of curiosity and creativity.
Hemostatic Dressing Immobilized with ε‐poly‐L‐lysine and Alginate Coated Mesoporous Bioactive Glass Prevents Blood Permeation by Pseudo‐Dewetting Behavior
Authors: Zilin Wu, Yilin Ding, Zhihao Qin, Zhipeng Sun, Zetao Wang, Xiaodong Cao
Journal: Advanced Healthcare Materials (2024)

The integration of hemostats with cotton fabrics is recognized as an effective approach to improve the hemostatic performance of dressings. However, concerns regarding the uncontrollable absorption of blood by hydrophilic dressings and the risk of distal thrombosis from shed hemostatic agents are increasingly scrutinized. To address these issues, this work develops an advanced dressing (AQG) with immobilized nano-scale mesoporous bioactive glass (MBG) to safely and durably augment hemostasis. The doubly immobilized MBGs, pre-coated with ε-poly-L-lysine and alginate, demonstrate less than 1% detachment after ultrasonic washing. Notably, this MBG layer significantly promotes the adhesion, aggregation, and activation of red blood cells and platelets, adhered five times more red blood cells and 29 times more platelets than raw dressing, respectively. Specially, with the rapid formation of protein corona and amplification of thrombin, dense fibrin network is built on MBG layer and then blocked blood permeation transversely and longitudinally, showing an autophobic pseudo-dewetting behavior and allowing AQG to concentrate blood in situ and culminate in faster hemostasis with lower blood loss. Furthermore, the potent antibacterial properties of AQG extend its potential for broader application in daily care and clinical setting.
Transgender and gender diverse older people: health, aging and dementia
Authors: Emily Asti, Naomi Beale, Nat Thorne, Tom Dening
Journal: International Journal of Transgender Health (2024)

Background and Objectives: 262,000 people in the UK identify as transgender and gender diverse (tGD), and this population is believed to be growing.As the population is aging, an increase in older tGD people accessing health and social care can be anticipated.Despite a recent expansion in research exploring the tGD population, older tGD people are often excluded from the narrative.this review aims to address gaps in the literature by exploring the complex ways older tGD adults access health and social care and how this affects health outcomes with a specific focus on dementia.Methods: the search was conducted using NUsearch, ciNAHl, PsyciNFO, PubMed, Google Scholar, and MeDliNe, in addition to cross-referencing and hand searches.Data were analyzed in a narrative, exploratory manner.Findings: Older tGD adults face many barriers when accessing health and social care including experiences of discrimination, gatekeeping by healthcare professionals and limited access to services.these barriers impact on health outcomes in this population and their interactions with the health and social care system.there are high reported rates of poor physical and mental health, including Hiv, mental illness and issues associated with gender-affirming treatment.Older tGD people are also reported to be at an increased risk of dementia, which is partly due to high incidences of dementia-associated risk factors.the epidemiology and experiences of older tGD people living with dementia are largely unknown due to limited research.However, the available literature suggests the current health and social care system is ill-equipped to manage their needs.Conclusion: Greater research exploring the major health problems faced by this population is needed, to address health inequalities.Several approaches have been suggested to help improve services for older tGD people including, expert patient programmes, co-production, and a systems approach.
A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma
Authors: Lisa Kinget, Stefan Naulaerts, Jannes Govaerts, Isaure Vanmeerbeek, Jenny Sprooten, Raquel S Laureano, Nikolina Dubroja, Gautam Shankar, Francesca M Bosisio, Eduard Roussel, Annelies Verbiest, Francesca Finotello, Markus Ausserhofer, Diether Lambrechts, Bram Boeckx, Agnieszka Wozniak, Louis Boon, Johan Kerkhofs, Jessica Zucman-Rossi, Maarten Albersen, Marcella Baldewijns, Benoit Beuselinck, Abhishek D Garg
Journal: Nature Medicine (2024)
A multimodal atlas of hepatocellular carcinoma reveals convergent evolutionary paths and ‘bad apple’ effect on clinical trajectory
Authors: Jianbin Chen, Neslihan Arife Kaya, Ying Zhang, Raden Indah Kendarsari, Karthik Sekar, Shay Lee Chong, Veerabrahma Pratap Seshachalam, Wen Huan Ling, Cheryl Zi Jin Phua, Hannah Lai, Hechuan Yang, Bingxin Lu, Jia Qi Lim, Siming Ma, Sin Chi Chew, Khi Pin Chua, Jacob Josiah Santiago Alvarez, Lingyan Wu, London Ooi, Alexander Yaw-Fui Chung, Peng Chung Cheow, Juinn Huar Kam, Alfred Wei-Chieh Kow, Iyer Shridhar Ganpathi, Chairat Bunchaliew, Jidapa Thammasiri, Peng Soon Koh, Diana Bee-Lan Ong, Jasmine Lim, Vanessa H. de Villa, Rouchelle D. Dela Cruz, Tracy Jiezhen Loh, Wei Keat Wan, Wei Qiang Leow, Yi Yang, Jin Liu, Anders Jacobsen Skanderup, Yin Huei Pang, Gwyneth Shook Ting Soon, Krishnakumar Madhavan, Tony Kiat-Hon Lim, Glenn Bonney, Brian K.P. Goh, Valerie Chew, Yock Young Dan, Han Chong Toh, Roger Sik-Yin Foo, Wai Leong Tam, Weiwei Zhai, Pierce Kah-Hoe Chow
Journal: Journal of Hepatology (2024)

Hepatocellular carcinoma (HCC) is a highly fatal cancer characterized by high intra-tumor heterogeneity (ITH). A panoramic understanding of its tumor evolution, in relation to its clinical trajectory, may provide novel prognostic and treatment strategies.
DNA damage response in brain tumors: A Society for Neuro-Oncology consensus review on mechanisms and translational efforts in neuro-oncology
Authors: Rifaquat Rahman, Diana D Shi, Zachary J Reitman, Petra Hamerlik, John F de Groot, Daphne A Haas-Kogan, Alan D D’Andrea, Erik P Sulman, Kirk Tanner, Nathalie Y R Agar, Jann N Sarkaria, Christopher L Tinkle, Ranjit S Bindra, Minesh P Mehta, Patrick Y Wen
Journal: Neuro-Oncology (2024)

DNA damage response (DDR) mechanisms are critical to maintenance of overall genomic stability, and their dysfunction can contribute to oncogenesis. Significant advances in our understanding of DDR pathways have raised the possibility of developing therapies that exploit these processes. In this expert-driven consensus review, we examine mechanisms of response to DNA damage, progress in development of DDR inhibitors in IDH-wild-type glioblastoma and IDH-mutant gliomas, and other important considerations such as biomarker development, preclinical models, combination therapies, mechanisms of resistance and clinical trial design considerations.
SMYD2-Methylated PPARγ Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy
Authors: Yi Li, Xiang Wei, Rui Xiao, Yongjie Chen, Tianxin Xiong, Ze-Min Fang, Bo Huo, Xian Guo, Hanshen Luo, Xingliang Wu, Liyuan Liu, Xue-Hai Zhu, Qinghua Hu, Ding-Sheng Jiang, Xin Yi
Journal: Circulation Research (2024)

Hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs) and consequent pulmonary vascular remodeling are the crucial pathological features of pulmonary hypertension (PH). Protein methylation has been shown to be critically involved in PASMC proliferation and PH, but the underlying mechanism remains largely unknown.
The state of the art in secondary pharmacology and its impact on the safety of new medicines
Authors: Richard J Brennan, Stephen Jenkinson, Andrew Brown, Annie Delaunois, Bérengère Dumotier, Malar Pannirselvam, Mohan Rao, Lyn Rosenbrier Ribeiro, Friedemann Schmidt, Alicia Sibony, Yoav Timsit, Vicencia Toledo Sales, Duncan Armstrong, Armando Lagrutta, Scott W Mittlestadt, Russell Naven, Ravikumar Peri, Sonia Roberts, James M Vergis, Jean-Pierre Valentin
Journal: Nature Reviews Drug Discovery (2024)