tbuckley/cabot-search huggingface dataset:
SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection
Authors: Hannah Goldswain, Rebekah Penrice-Randal, I’ah Donovan-Banfield, Craig W. Duffy, Xiaofeng Dong, Nadine Randle, Yan Ryan, Aleksandra M. Rzeszutek, Jack Pilgrim, Emma Keyser, Simon A. Weller, Emma J. Hutley, Catherine Hartley, Tessa Prince, Alistair C. Darby, Niall Aye Maung, Henry Nwume, Julian A. Hiscox, Stevan R. Emmett
Journal: Genome Medicine (2024)

Abstract Background SARS-CoV-2 remains rapidly evolving, and many biologically important genomic substitutions/indels have characterised novel SARS-CoV-2 lineages, which have emerged during successive global waves of the pandemic. Worldwide genomic sequencing has been able to monitor these waves, track transmission clusters, and examine viral evolution in real time to help inform healthcare policy. One school of thought is that an apparent greater than average divergence in an emerging lineage from contemporary variants may require persistent infection, for example in an immunocompromised host. Due to the nature of the COVID-19 pandemic and sampling, there were few studies that examined the evolutionary trajectory of SARS-CoV-2 in healthy individuals. Methods We investigated viral evolutionary trends and participant symptomatology within a cluster of 16 SARS-CoV-2 infected, immunocompetent individuals with no co-morbidities in a closed transmission chain. Longitudinal nasopharyngeal swab sampling allowed characterisation of SARS-CoV-2 intra-host variation over time at both the dominant and minor genomic variant levels through Nimagen-Illumina sequencing. Results A change in viral lineage assignment was observed in individual infections; however, there was only one indel and no evidence of recombination over the period of an acute infection. Minor and dominant genomic modifications varied between participants, with some minor genomic modifications increasing in abundance to become the dominant viral sequence during infection. Conclusions Data from this cohort of SARS-CoV-2-infected participants demonstrated that long-term persistent infection in an immunocompromised host was not necessarily a prerequisite for generating a greater than average frequency of amino acid substitutions. Amino acid substitutions at both the dominant and minor genomic sequence level were observed in immunocompetent individuals during infection showing that viral lineage changes can occur generating viral diversity.
ACKR1+ Endothelial Cells Mediate Leukocyte Infiltration and Synergize with SFRP2/ASPN+ Fibroblasts to Promote Skin Fibrosis in Systemic Sclerosis
Authors: Yan Huang, Weilin Pu, Lei Wang, Qianqian Ma, Yanyun Ma, Qingmei Liu, Shuai Jiang, Xiangyue Zhao, Yuting Zhang, Qiuyu He, Yulong Tang, Jing Liu, Jui-Ming Lin, Xiangguang Shi, Wenzhen Tu, Yuanyuan Chen, Jinran Lin, Yiyi Gong, Wenyu Wu, Jiucun Wang
Journal: British Journal of Dermatology (2024)

Abstract Background Skin fibrosis is the typical pathological manifestation of systemic sclerosis (SSc) and localized scleroderma (LS); it has an unclear aetiology and few effective treatments. Although excessive collagen secretion by fibroblasts is the primary cause of skin fibrosis, evidence has suggested that vascular damage is the initiating event and that various cell types, including fibroblasts, work together to contribute to the pathogenesis of skin fibrosis. Objectives To explore the relationship between vascular endothelial cell lesions and immune cell infiltration, along with the interactions between various cell types within the fibrotic skin ecosystem. Methods Single-cell RNA sequencing was performed on skin biopsies from three healthy donors and seven patients with SSc. Additional data from three patients with localized scleroderma available in the Gene Expression Omnibus (GSE160536) were integrated by Harmony. CellChat (version 1.5.0) was used to analyse the cell communication network. A Transwell® assay and a bleomycin (BLM) mouse model were used to explore the role of atypical chemokine receptor 1 (ACKR1; ‘Duffy antigen’) in immune cell infiltration. Milo single-cell Western blot was used to show fibroblast subcluster activation. Results A total of 62 295 cells were obtained and subpopulations of stromal and immune cells identified. Interaction network analysis found that multiple chemokines secreted by macrophages, pericytes and proinflammatory fibroblasts could bind with ACKR1, which was highly expressed by endothelial cells in lesional skin. The Transwell® assay revealed that overexpression of ACKR1 in human umbilical vein endothelial cells facilitated leucocyte infiltration following treatment with interleukin-8. BLM mice showed enhanced ACKR1 expression, massive immune cell infiltration and skin fibrosis that was attenuated by ACKR1 inhibition. Furthermore, infiltrated macrophages expressing high levels of transforming growth factor (TGF)-β1 or platelet-derived growth factor B (PDGFB) could activate secreted frizzled-related protein 2 (SFRP2)/asporin (ASPN)+ fibroblasts to contribute to the excessive accumulation of extracellular matrix. It was also found that the SOX4–ASPN axis plays an important role in the TGF-β signalling cascade and the aetiology of skin fibrosis. Conclusions Our results reveal that high expression of ACKR1 by endothelial cells in fibrotic skin tissue promotes immune cell infiltration and that SFRP2/ASPN+ fibroblasts synergize to exacerbate skin fibrosis.
Interaction proteomics analysis to provide insight into TFAMoplex-mediated transfection
Authors: Steffen Honrath, David Scherer, Michael Burger, Jean-Christophe Leroux
Journal: Journal of Controlled Release (2024)

In an earlier investigation, our group introduced the TFAMoplex, a transfection agent based on the mitochondrial transcription factor A (TFAM) protein, which complexes DNA into nanoparticles. The original TFAMoplex further contained a bacterial phospholipase to achieve endosomal escape, and the vaccinia-related kinase 1 (VRK1), which significantly boosted the transfection efficiency of the system by an unknown mechanism. This study aims at replacing VRK1 within the TFAMoplex with dynein light chain proteins, specifically RP3, to directly tether the complexes to the dynein motor complex for enhanced cytosolic transport. To confirm the interaction between the dynein complex and the resulting fusion protein, we examined the binding kinetics of TFAM-RP3 to the dynein intermediate chains 1 and 2. Furthermore, we established a proteomics-based assay to compare cytosolic protein interactions of different TFAMoplex variants, including the RP3-modified version and the original VRK1-containing system. In the group of the VRK1-containing TFAMoplex, significant shifts of protein interactors were observed, especially for nucleolar proteins. Leveraging this knowledge, we incorporated one of these nuclear proteins, leucine-rich repeat-containing protein 59 (LRRC59), into the TFAMoplex, resulting in a significant improvement of transfection properties compared to the RP3-modified system and comparable levels versus the original, VRK1-containing version. This study not only advances our comprehension of the TFAMoplex system but also offers broader insights into the potential of protein engineering for designing effective gene delivery systems.
Meta-analysis of Individual Patient-level Data for a Multimodal Artificial Intelligence Biomarker in High-risk Prostate Cancer: Results from Six NRG/RTOG Phase 3 Randomized Trials
Authors: Daniel E Spratt, Vinnie Y T Liu, Angela Y Jia, Trevor J Royce, Howard M Sandler, Stephanie L Pugh, Phuoc T Tran, Felix Y Feng
Journal: European Urology (2024)
Re: Nicolaus F. Debatin, Elena Bady, Tim Mandelkow, et al. Prognostic Impact and Spatial Interplay of Immune Cells in Urothelial Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2024.01.023
Authors: Tiezheng Qi, Benyi Fan, Dingshan Deng
Journal: European Urology (2024)
Reappraisal of transarterial radioembolization for liver-confined hepatocellular carcinoma with portal vein tumor thrombosis: Editorial on “Transarterial radioembolization versus tyrosine kinase inhibitor in hepatocellular carcinoma with portal vein thrombosis”
Authors: Jin Hyoung Kim, Gun Ha Kim, Dong Il Gwon
Journal: Clinical and Molecular Hepatology (2024)
Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals
Authors: Masato Akiyama, Gen Tamiya, Kohta Fujiwara, Yukihiro Shiga, Yu Yokoyama, Kazuki Hashimoto, Masataka Sato, Kota Sato, Akira Narita, Sawako Hashimoto, Emi Ueda, Yoshihiko Furuta, Jun Hata, Masahiro Miyake, Hanako O. Ikeda, Kenji Suda, Shogo Numa, Yuki Mori, Kazuya Morino, Yusuke Murakami, Sakurako Shimokawa, Shun Nakamura, Nobuyo Yawata, Kimihiko Fujisawa, Satoshi Yamana, Kenichiro Mori, Yasuhiro Ikeda, Kazunori Miyata, Keisuke Mori, Ken Ogino, Yoshito Koyanagi, Yoichiro Kamatani, Koichi Matsuda, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yukinori Okada, Yoshinori Murakami, Kaori Muto, Akiko Nagai, Yusuke Nakamura, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Shinichi Higashiue, Shuzo Kobayashi, Hiroki Yamaguchi, Yasunobu Nagata, Satoshi Wakita, Chikako Nito, Yu-Ki Iwasaki, Shigeo Murayama, Kozo Yoshimori, Yoshio Miki, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yoshinobu Koga, Yukihiro Koretsune, Toshiharu Ninomiya, Koh-Hei Sonoda, Toru Nakazawa, Makoto Aihara, Rei Sakata, Kenji Kashiwagi, Fumihiko Mabuchi, Kazuhide Kawase, Takeshi Iwata, Motokazu Tsujikawa, Koji M. Nishiguchi
Journal: Ophthalmology (2024)
Incidence of and risk factors for small vulnerable newborns in north India: a secondary analysis of a prospective pregnancy cohort
Authors: Ramachandran Thiruvengadam, None Ayushi, Deepika Rathna Murugesan, Bapu Koundinya Desiraju, Sumit Misra, Dharmendra Sharma, Suresh Somi Subbaian, Umesh Mehta, Alka Singh, Sunita Sharma, Ashok Khurana, Pratima Mittal, Harish Chellani, Rekha Bharti, Reva Tripathi, Shailaja Sopory, Pallavi Kshetrapal, Dinakar M Salunke, Uma Chandra Mouli Natchu, Siddarth Ramji, Nitya Wadhwa, Shinjini Bhatnagar
Journal: The Lancet Global Health (2024)

Globally, recent estimates have shown there have been 3·6 million stillbirths and neonatal deaths in 2022, with nearly 60% occurring in low-income and middle-income countries. The Small Vulnerable Newborn Consortium has proposed a framework combining preterm birth (<37 weeks of gestation), small for gestational age (SGA) by INTERGROWTH-21st standard, and low birthweight (<2500 g) under the category small vulnerable newborns (SVN). Reliable data on SVN from sub-Saharan Africa, central Asia, and south Asia are sparse. We aimed to estimate the incidence of SVN and its types, and quantify risk factors, both overall and trimester-specific, from a pregnancy cohort in north India.
A successful UN High-Level Meeting on antimicrobial resistance must build on the 2023 UN High-Level Meeting on tuberculosis
Authors: Daniela Cirillo, Richard Anthony, Sebastien Gagneux, C Robert Horsburgh, Rumina Hasan, Saffiatou Darboe, Rafael Laniado-Laborin, Ari Probandari, Nestani Tukvadze, Ricardo A Arcêncio, John S Bimba, Susanna Brighenti, Dumitru Chesov, Chen-Yuan Chiang, Gulmira Kalmambetova, Gwenan Knight, Olha Konstantynovska, Alexandra Kruse, Christoph Lange, Harriet Mayanja-Kizza, Emma McBryde, Jinsoo Min, Adrian Sanchez-Montalva, Giorgia Sulis, Bazarragchaa Tsogt, Martie Van Der Walt, Dorothy Yeboah-Manu, Janika Hauser
Journal: The Lancet Global Health (2024)
Receipt of hepatitis E vaccine and fetal loss in rural Bangladesh: further analysis of a double-blind, cluster-randomised, controlled trial
Authors: Asma Binte Aziz, Susanne Dudman, Cathinka Halle Julin, Faisal Ahmmed, Kathrine Stene-Johansen, Synne Sandbu, Joakim Øverbø, Jennifer L Dembinski, Torbjørn Wisløff, Sohel Rana, Ahsan-Ul Habib Basunia, Warda Haque, Firdausi Qadri, Khalequ Zaman, John D Clemens
Journal: The Lancet Global Health (2024)

Vaccination constitutes an attractive control measure for hepatitis E virus (HEV), a major cause of maternal and perinatal mortality globally. Analysis of pregnant participants in an effectiveness trial of the HEV vaccine HEV239 showed possible HEV239-associated fetal losses. We aimed to conduct a detailed analysis of this safety signal.
HIV incidence among women engaging in sex work in sub-Saharan Africa: a systematic review and meta-analysis
Authors: Harriet S Jones, Rebecca L Anderson, Henry Cust, R Scott McClelland, Barbra A Richardson, Harsha Thirumurthy, Kalonde Malama, Bernadette Hensen, Lucy Platt, Brian Rice, Frances M Cowan, Jeffrey W Imai-Eaton, James R Hargreaves, Oliver Stevens
Journal: The Lancet Global Health (2024)

Women who engage in sex work in sub-Saharan Africa have a high risk of acquiring HIV infection. HIV incidence has declined among all women in sub-Saharan Africa, but trends among women who engage in sex work are poorly characterised. We synthesised data on HIV incidence among women who engage in sex work in sub-Saharan Africa and compared these with the total female population to understand relative incidence and trends over time.
Risk estimation for the primary prevention of cardiovascular disease: considerations for appropriate risk prediction model selection
Authors: Kim Robin van Daalen, Dudan Zhang, Stephen Kaptoge, Ellie Paige, Emanuele Di Angelantonio, Lisa Pennells
Journal: The Lancet Global Health (2024)

Cardiovascular diseases remain the number one cause of death globally. Cardiovascular disease risk scores are an integral tool in primary prevention, being used to identify individuals at the highest risk and guide the assignment of preventive interventions. Available risk scores differ substantially in terms of the population sample data sources used for their derivation and, consequently, in the absolute risks they assign to individuals. Differences in cardiovascular disease epidemiology between the populations contributing to the development of risk scores, and the target populations in which they are applied, can result in overestimation or underestimation of cardiovascular disease risks for individuals, and poorly informed clinical decisions. Given the wide plethora of cardiovascular disease risk scores available, identification of an appropriate risk score for a target population can be challenging. This Review provides an up-to-date overview of guideline-recommended cardiovascular disease risk scores from global, regional, and national contexts, evaluates their comparative characteristics and qualities, and provides guidance on selection of an appropriate risk score.
Safety and effectiveness of a recombinant hepatitis E vaccine in women of childbearing age in rural Bangladesh: a phase 4, double-blind, cluster-randomised, controlled trial
Authors: Khalequ Zaman, Cathinka Halle Julin, Asma Binte Aziz, Kathrine Stene-Johansen, Md Yunus, Firdausi Qadri, Emily S Gurley, Synne Sandbu, Joakim Øverbø, Jennifer L Dembinski, Ida Laake, Taufiqur R Bhuiyan, Mustafizur Rahman, Warda Haque, Mahbuba Khanam, John D Clemens, Susanne Dudman
Journal: The Lancet Global Health (2024)

Hepatitis E virus (HEV) leads to high mortality in pregnant women in low-income countries. We aimed to evaluate the safety of a HEV vaccine and its effectiveness in preventing hepatitis E during pregnancy.
Resistance-informed versus empirical management of viraemia in children and adolescents with HIV in Lesotho and Tanzania (GIVE MOVE trial): a multisite, open-label randomised controlled trial
Authors: Jennifer Anne Brown, Isaac Kaumbuthu Ringera, Ezekiel Luoga, Moniek Bresser, Buoang Mothobi, Lorraine Kabundi, Mulume Ilunga, Kuena Mokhele, Andreas Boy Isaac, Ntsepiseng Tsoaeli, Thomas Mbaya, Brenda Simba, Kasasi Mayogu, Elizabeth Mabula, Molisana Cheleboi, Mamello Molatelle, Namvua Kimera, Getrud Joseph Mollel, David Sando, Nadine Tschumi, Alain Amstutz, Lineo Thahane, Mosa Molapo Hlasoa, Buntshi Paulin Kayembe, Josephine Muhairwe, Thomas Klimkait, Tracy Renée Glass, Maja Weisser, Niklaus Daniel Labhardt
Journal: The Lancet Global Health (2024)

Children and adolescents with HIV taking antiretroviral therapy (ART) have high rates of viraemia. We assessed if genotypic resistance testing (GRT) to inform onward treatment improved treatment outcomes in Lesotho and Tanzania, two countries with little access to GRT.
Temporal changes in cause of death among adolescents and adults in six countries in eastern and southern Africa in 1995–2019: a multi-country surveillance study of verbal autopsy data
Authors: Yue Chu, Milly Marston, Albert Dube, Charles Festo, Eveline Geubbels, Simon Gregson, Kobus Herbst, Chodziwadziwa Kabudula, Kathleen Kahn, Tom Lutalo, Louisa Moorhouse, Robert Newton, Constance Nyamukapa, Ronald Makanga, Emma Slaymaker, Mark Urassa, Abdhalah Ziraba, Clara Calvert, Samuel J Clark
Journal: The Lancet Global Health (2024)

The absence of high-quality comprehensive civil registration and vital statistics systems across many settings in Africa has led to little empirical data on causes of death in the region. We aimed to use verbal autopsy data to provide comparative, population-based estimates of cause-specific mortality among adolescents and adults in eastern and southern Africa.
Generating synthetic computed tomography for radiotherapy: SynthRAD2023 challenge report
Authors: Evi M.C. Huijben, Maarten L. Terpstra, Arthur Jr. Galapon, Suraj Pai, Adrian Thummerer, Peter Koopmans, Manya Afonso, Maureen van Eijnatten, Oliver Gurney-Champion, Zeli Chen, Yiwen Zhang, Kaiyi Zheng, Chuanpu Li, Haowen Pang, Chuyang Ye, Runqi Wang, Tao Song, Fuxin Fan, Jingna Qiu, Yixing Huang, Juhyung Ha, Jong Sung Park, Alexandra Alain-Beaudoin, Silvain Bériault, Pengxin Yu, Hongbin Guo, Zhanyao Huang, Gengwan Li, Xueru Zhang, Yubo Fan, Han Liu, Bowen Xin, Aaron Nicolson, Lujia Zhong, Zhiwei Deng, Gustav Müller-Franzes, Firas Khader, Xia Li, Ye Zhang, Cédric Hémon, Valentin Boussot, Zhihao Zhang, Long Wang, Lu Bai, Shaobin Wang, Derk Mus, Bram Kooiman, Chelsea A.H. Sargeant, Edward G.A. Henderson, Satoshi Kondo, Satoshi Kasai, Reza Karimzadeh, Bulat Ibragimov, Thomas Helfer, Jessica Dafflon, Zijie Chen, Enpei Wang, Zoltan Perko, Matteo Maspero
Journal: Medical Image Analysis (2024)

Radiation therapy plays a crucial role in cancer treatment, necessitating precise delivery of radiation to tumors while sparing healthy tissues over multiple days. Computed tomography (CT) is integral for treatment planning, offering electron density data crucial for accurate dose calculations. However, accurately representing patient anatomy is challenging, especially in adaptive radiotherapy, where CT is not acquired daily. Magnetic resonance imaging (MRI) provides superior soft-tissue contrast. Still, it lacks electron density information, while cone beam CT (CBCT) lacks direct electron density calibration and is mainly used for patient positioning. Adopting MRI-only or CBCT-based adaptive radiotherapy eliminates the need for CT planning but presents challenges. Synthetic CT (sCT) generation techniques aim to address these challenges by using image synthesis to bridge the gap between MRI, CBCT, and CT. The SynthRAD2023 challenge was organized to compare synthetic CT generation methods using multi-center ground truth data from 1080 patients, divided into two tasks: (1) MRI-to-CT and (2) CBCT-to-CT. The evaluation included image similarity and dose-based metrics from proton and photon plans. The challenge attracted significant participation, with 617 registrations and 22/17 valid submissions for tasks 1/2. Top-performing teams achieved high structural similarity indices (≥0.87/0.90) and gamma pass rates for photon (≥98.1%/99.0%) and proton (≥97.3%/97.0%) plans. However, no significant correlation was found between image similarity metrics and dose accuracy, emphasizing the need for dose evaluation when assessing the clinical applicability of sCT. SynthRAD2023 facilitated the investigation and benchmarking of sCT generation techniques, providing insights for developing MRI-only and CBCT-based adaptive radiotherapy. It showcased the growing capacity of deep learning to produce high-quality sCT, reducing reliance on conventional CT for treatment planning.
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine
Authors: Opeyemi Stella Ademowo, Markus R. Wenk, Andrea B. Maier
Journal: Ageing Research Reviews (2024)

It is imperative to optimise health and healthspan across the lifespan. The accumulation of reactive oxygen species (ROS) has been implicated in the hallmarks of ageing and inhibiting ROS production can potentially delay ageing whilst increasing healthy longevity. Lipids and lipid mediators (derivatives of lipids) are becoming increasingly recognized as central molecule in tissue and cellular function and are susceptible to peroxidation; hence linked with ageing. Lipid classes implicated in the ageing process include sterols, glycerophospholipids, sphingolipids and the oxidation products of polyunsaturated fatty acids but these are not yet translated into the clinic. Further mechanistic studies are required for the understanding of lipid classes in the ageing process. Lipidomics, the system level characterisation of lipid species with respect to metabolism and function, might provide a significant and useful biological age profiling tool through longitudinal studies. Lipid profiles in different ages among healthy individuals could be harnessed as lipid biomarkers of healthy ageing with potential integration for the development of lipid-based ageing clock (lipid clock). The potential of a lipid clock includes the prediction of future morbidity or mortality, which will promote precision and healthy longevity medicine.
Longitudinal Analyses of Circulating Tumor DNA for the Detection of EGFR Mutation-Positive Advanced NSCLC Progression During Treatment: Data From FLAURA and AURA3
Authors: Jhanelle E Gray, Aleksandra Markovets, Thanyanan Reungwetwattana, Margarita Majem, Naoyuki Nogami, Nir Peled, Jong-Seok Lee, Byoung Chul Cho, Busayamas Chewaskulyong, Tom John, Ji-Youn Han, Martin Sebastian, Alexander Todd, Yuri Rukazenkov, Carl Barrett, Juliann Chmielecki, Siow Ming Lee, Suresh S Ramalingam, Ryan Hartmaier
Journal: Journal of Thoracic Oncology (2024)

EGFR tyrosine kinase inhibitor (EGFR-TKI)-sensitizing and -resistance mutations may be detected in plasma through circulating tumor DNA (ctDNA). Circulating tumor DNA level changes reflect alterations in tumor burden and could be a dynamic indicator of treatment effect. This analysis aimed to determine whether longitudinal EGFR-mutation ctDNA testing could detect progressive disease (PD) before radiologic detection.
Precision Oncology and Systemic Targeted Therapy in Pseudomyxoma Peritonei
Authors: Jordi Martínez-Quintanilla, Débora Cabot, Doménico Sabia, Oriol Arqués, Jordi Vergés, Irene Chicote, Lana Bijelic, Laia Cabellos, Anna M. Alcántara, Isabel Ramos, Pedro Barrios, Oriol Crusellas, Lina M. Palacio, Juan A. Cámara, Jorge Barriuso, Juan J. Jiménez, Pau Muñoz-Torres, Lara Nonell, Raquel Flores, Enzo Médico, Marcello Guaglio, Javier Ros, Elena Élez, Josep Tabernero, Omer Aziz, Marcello Deraco, Héctor G. Palmer, Chiorino Giovanna, Mazzarotto Francesco, Gariboldi Manuela, Varinelli Luca, Cavalleri Tommaso, Chakrabarty Bipasha, Nagaraju Raghavendar, Caswell Patrick, McAllister Milly
Journal: Clinical Cancer Research (2024)

Pseudomyxoma peritonei (PMP) is a rare and poorly understood malignant condition characterized by the accumulation of intra-abdominal mucin produced from peritoneal metastases. Currently, cytoreductive surgery remains the mainstay of treatment but disease recurrence and death after relapse frequently occur in patients with PMP. New therapeutic strategies are therefore urgently needed for these patients.
Oral Nirmatrelvir–Ritonavir as Postexposure Prophylaxis for Covid-19
Authors: Jennifer Hammond, Carla Yunis, Robert J. Fountaine, Gerald Luscan, Aimee M. Burr, Wuyan Zhang, Wayne Wisemandle, Holly Soares, Mary Lynn Baniecki, Victoria M. Hendrick, Veselin Kalfov, Rienk Pypstra, James M. Rusnak
Journal: New England Journal of Medicine (2024)

Clinical trials of treatments for coronavirus disease 2019 (Covid-19) have not shown a significant benefit of postexposure prophylaxis.