MULTIPLE REMISSIONS IN AN ADULT WITH ACUTE LEUKEMIA TREATED PRINCIPALLY WITH A-METHOPTERIN
Authors: R L ENGLE, E F HAYS, T C SCANLAN
Journal: Annals of Internal Medicine (1956)

Case Reports1 August 1956MULTIPLE REMISSIONS IN AN ADULT WITH ACUTE LEUKEMIA TREATED PRINCIPALLY WITH A-METHOPTERINESTHER FINCHER HAYS, M.D., THOMAS C. SCANLAN, M.D., RALPH L. ENGLE JR., M.D.ESTHER FINCHER HAYS, M.D.Search for more papers by this author, THOMAS C. SCANLAN, M.D.Search for more papers by this author, RALPH L. ENGLE JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-2-306 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe subject of this case report lived for nearly five years after the diagnosis of acute leukemia was made. The course of the disease was unique in that it contained three distinct clinical remissions, each initiated by treatment with a-methopterin. The course and therapy are depicted in figure 1.CASE REPORTA 32 year old German Jewish housewife was admitted to the New York Hospital in June, 1949, with a history of fatigability, fever, sore throat and swollen neck glands for two months.Physical examination revealed fever and pallor. Petechiae, bleeding hypertrophied gums and small cervical lymph nodes were also...Bibliography1. SouthamCraverDargeonBurchenal CMLFHWJH: A study of the natural history of acute leukemia with special reference to duration of disease and occurrence of remissions, Cancer 4: 39, 1951. CrossrefMedlineGoogle Scholar2. BirgeJenksDavis RFALSK: Spontaneous remission in acute leukemia, J. A. M. A. 140: 589, 1949. CrossrefMedlineGoogle Scholar3. DameshekFreedmanSteinberg WMHL: Folic acid antagonists in the treatment of acute and subacute leukemia, Blood 5: 898, 1950. CrossrefMedlineGoogle Scholar4. StickneyMillsHagedornCooper JMSDABT: The treatment of acute leukemia with folic acid antagonists, Proc. Staff Meet., Mayo Clin. 24: 525, 1949. MedlineGoogle Scholar5. BurchenalKarnofskyKingsley-PillersSouthamMyersEscherCraverDargeonRhoads JHDAEMCMWPGCLFHWCP: The effects of folic acid antagonists and 2,6-diaminopurine on neoplastic disease, Cancer 4: 549, 1951. CrossrefMedlineGoogle Scholar6. SacksBradfordSchoenbach MSGTEB: The response of acute leukemia to the administration of the folic acid antagonists, aminopterin and a-methopterin: report of 14 cases, Ann. Int. Med. 32: 80, 1950. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication May 23, 1955.From Department of Medicine, New York Hospital-Cornell Medical Center.Presented in part at the Society for the Study of Blood, New York, May 26, 1953.†Present address: Atomic Energy Project, University of California.‡Markle Scholar in Medical Science.Requests for reprints should be addressed to Ralph L. Engle, Jr., M.D., The New York Hospital, 525 East Sixty-eighth Street, New York 21, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1956Volume 45, Issue 2Page: 306-311KeywordsAdrenocorticotropic hormoneAnemiaBloodFeversHemorrhageHepatitis ALymph nodesPharyngitisThrombocytopenia ePublished: 1 December 2008 Issue Published: 1 August 1956 PDF downloadLoading ...