tbuckley/cabot-search huggingface dataset:
Impact of Metabolic Syndrome on Tissue Characteristics of Angiographically Mild to Moderate Coronary Lesions
Authors: Tetsuya Amano, Tatsuaki Matsubara, Tadayuki Uetani, Michio Nanki, Nobuyuki Marui, Masataka Kato, Kosuke Arai, Kiminobu Yokoi, Hirohiko Ando, Hideki Ishii, Hideo Izawa, Toyoaki Murohara
Journal: Journal of the American College of Cardiology (2007)
Early Care of the Injured Patient.
Authors: Alexander J. Walt
Journal: Annals of Internal Medicine (1973)

This book on emergency treatment of traumatic injuries originally began as a combination of two paperback pocket manuals developed by the American College of Surgeons: An Outline of Treatment of Fractures and The Early Care of Acute Soft Tissue Injuries. For those health professionals routinely involved in care of traumatic injuries, this manual could serve as an aid in teaching, while it would be a valuable reference in the library of the physician who is not ordinarily involved in emergency
Abstract 16953: Effects of Exercise Training on PGC1{alpha} and Skeletal Muscle Function in Patients with Chronic Heart Failure - An Age-Stratified Study
Authors: Marcus Sandri, Volker Adams, Norman Mangner, Gerhard Schuler, Stephan Gielen
Journal: Circulation (2011)

Introduction: Despite its prognostic implications the mechanisms of skeletal muscle wasting in chronic heart failure (CHF) are still not completely understood. We have previously documented a catab...
Radiology: Diagnosis, Imaging, Intervention.
Authors: Juan M. Taveras, Joseph T. Ferrucci
Journal: Annals of Internal Medicine (1991)

Volume 1: radiologic physics pulmonary radiology. Volume 2: cardiac radiology vascular radiology. Volume 3: neuroradiology and radiology of the head and neck. Volume 4: gastrointestinal radiology radiology of the general abdomen and pelvis genitourinary radiology. Volume 5 Skeletal radiology.
Vascular Hamartomas and Angiodysplasias of the Extremities.
Authors: Italo Federico Goidanich, Mario Campanacci
Journal: Annals of Internal Medicine (1970)

covers all the forms of vascular and lymphatic malformation of congenital origin and also includes acquired vascular lesions related to angiomas. A detailed classification of the different lesions serves as an introduction, while the bulk of the volume relates the authors' personal observations and studies in 100 cases. Clinical examinations were often supplemented by angiographic studies, oximetry of the venous blood, plethysmography, and histologic examination of biopsies. In six cases three dimensional reconstructions were made by the use of serial sections. The authors also made excellent use of the publications of other investigators, to which they referred in a 24-page bibliography. The result is a significant contribution to the understanding of vascular lesions that have previously been of little interest to and not well understood by most clinicians. The information imparted in this volume is, however, largely in the field of ap¬ plied physiology and clinical diag¬ nosis. Unfortunately the authors have little to add regarding therapy and the results to be anticipated. The volume is profusely and clear¬ ly illustrated, even including a 17page color atlas. The English trans¬ lation is so well done that one is un¬ aware that he is not reading the text in its original language. Theodore B. Massell, MD Los Angeles
Abstract 20881: Increased Peri-Infarct Calcium Alternans Underlies Spontaneous VT and Sudden Death in LQT1 Rabbits Post Myocardial Infarction
Authors: Ohad Ziv, Lorraine Schofield, Lenny Chaves, Emily Lau, Xuwen Peng, Gideon Koren, Bum-Rak Choi
Journal: Circulation (2010)

The incidence SCD in the general population correlates with prolongation of the QT interval. We investigated the mechanism by which reduced repolarization reserve may affect post myocardial infarct...
Abstract 9558: Overnight Use of Adaptive Servo Ventilation Reduces Cardiac Overload and Improves Renal Function in Patients with Chronic Heart Failure and Cheyne-Stokes Respiration
Authors: Akiomi Yoshihsa, Satoshi Suzuki, Makiko Miyata, Takamasa Sato, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitho, Yasuchika Takeishi
Journal: Circulation (2011)

Background: Cheyne-Stokes respiration associated with central sleep apnea (CSR-CSA) deteriorates the prognosis of patients with chronic heart failure (CHF). Adaptive servo ventilation (ASV) is a new therapeutic modality to treat CSR-CSA. Renal function plays critical roles in the progression of CHF and is a strong predictor of clinical outcomes. Cystatin C is a more sensitive marker of renal function than creatinine. The purpose of the present study was to examine whether ASV is effective for cardiac overload and renal dysfunction in CHF with CSR-CSA. Methods and Results: Forty two patients with CHF and CSR-CSA (mean age 62.0 ± 11.8, male 37, New York Heart Association functional class 2.5 ± 0.6, mean left ventricular ejection fraction 34.6 ± 12.6%) were examined. We performed polysomnography for consecutive two days (baseline and on ASV), and measured levels of plasma N terminal pro B-type natriuretic peptide (NT-pro BNP), cystatin C, and estimated glomerular filtration rate (eGFR) by the MDRD formula. ASV significantly imporved apnea hypopnea index (39.0 ± 17.3 to 9.9 ± 7.9 /h, P&lt;0.01), central apnea index (17.6 ± 14.2 to 1.1 ± 1.6 /h, P&lt;0.01), arousal index (25.9 ± 9.0 to 16.7 ± 7.5 /h, P&lt;0.01), mean SPO 2 (94.7 ± 2.8 to 96.7 ± 1.6%, P&lt;0.01), and lowest SPO 2 (79.1 ± 8.9 to 89.2 ± 5.8%, P&lt;0.01) compared to baseline. ASV reduced mean heart rate (72.1 ± 10.8 to 67.4 ± 9.8 bpm, P&lt;0.01). ASV decreased levels of log NT-pro BNP (3.032 ± 0.725 to 2.955 ± 0.714, P&lt;0.01) and cystatin C (1.337 ± 0.546 to 1.284 ± 0.471 mg/l, P&lt;0.05), and improved eGFR (67.1 ± 32.4 to 70.4 ± 36.2 ml/min/1.73cm 2 , P&lt;0.01). Conclusions: ASV improved CSR-CSA, reduced cardiac overload, and protected renal function in chronic heart failure patients with Cheyne-Stokes respiration. ASV has short-term (overnight) beneficial effects on not only CSR-CSA but also renal function. ASV might be a promising useful tool for chronic heart failure as an important non-pharmacotherapy.
Abstract 1004: Administration Of A Glucagon-like Peptide-1 Receptor Agonist Prevents Cardiac Rupture And Increases Survival In Mice Undergoing Myocardial Infarction
Authors: Mohammad H Noyan-Ashraf, AlMuktafi Sadi, Mohamad Abdul Momen, Daniel J Drucker, Mansoor Husain
Journal: Circulation (2007)
Severe Hyperphosphatemia and Hypocalcemia Following Sodium Phosphate Bowel Preparation: A Forgotten Menace
Authors: K K Ma, C S H Ng, L M Mui, K C Chan, E K W Ng, S C S Chung
Journal: Endoscopy (2003)

A 74-year-old woman was scheduled for colonoscopy due to positive fecal occult blood. On admission, her serum levels of creatinine, adjusted calcium, and phosphate were 113 µmol/l, 2.24 mmol/l, and 1.17 mmol/l, respectively. She received 90 ml of oral Fleet Phospho-Soda (C.B. Fleet Co. Inc., Lynchburg, Virginia, USA), from which she developed profuse diarrhea. Six hours later, she complained of facial and limb numbness, and appeared drowsy. Her serum phosphate level had risen to 7.29 mmol/l and her calcium level had fallen to 1.82 mmol/l. During the next hour, muscle cramps and tetany developed over her lower limbs, trunk, and face, with a positive Chvostek’s sign. Intravenous administration of 9.0 mmol (40 ml 10 %) calcium gluconate was carried out over 6 h, resulting in resolution of her tetany, while the numbness persisted over the distal limbs. Further infusions totaling 24.75 mmol calcium gluconate were required over the next 17 h to restore the calcium level to 2.32 mmol/l (Figure [1]). Extensive investigations excluded a secondary cause of the electrolyte disturbance.
Determinants of preferences for starting extended adjuvant letrozole (L) in postmenopausal women following five years of tamoxifen
Authors: C. Luk, P. Goss, K. Pritchard, T. J. Whelan, S. Liu, L. Shepherd, J. Pater
Journal: Journal of Clinical Oncology (2005)

642 Background: The NCIC CTG MA.17 trial was a multi-center study that demonstrated a 5% improvement in 4 year DFS for extended adjuvant L after 5 years of adjuvant tamoxifen in postmenopausal women with early stage breast cancer. The study was terminated at the first interim analysis in view of the positive results and all patients (pts) on the placebo (P) arm were offered the choice of L for 5 years. This study explored the determinants of patients’ decision to start L after tamoxifen. Methods: Pts’ characteristics including age, race, ECOG status, T, N stage of original breast cancer, geographic location, concomitant medical complaints, previous adjuvant chemotherapy/radiotherapy, toxicity symptom scores, history of cardiac disease or osteoporosis and duration on study were collected. Multivariate logistic regression modeling with a method of backward selection was used to predict the association of the patient’s decision to start L. Variations in L use within Canada and USA were determined using the chi-square test. P< 0.05 was considered statistically significant. Results: Of 2587 pts randomized to P, information of their choice was available in 1612. 1223 (75.9%) had decided to start L. Pts who were younger (< =70) (OR 2.05, p< 0.001), had node positive disease (OR 1.39, p=0.0095), were in US centres (OR 1.81, p< 0.0001), and had endocrine symptoms while on P (OR 1.32, p=0.0497) were more likely to start on L. Pts with flu-like symptoms while on P and longer time on P were more likely to opt for no further treatment (OR 0.69, p=0.0063 and OR 0.96, p< 0.0001 respectively). There was significant geographic difference in preference for L within Canada (p=< 0.0001) but not in the USA. Conclusions: Our results showed age, nodal status, endocrine symptomatology, and being in the USA, were associated with preference for starting L after tamoxifen. There were significant regional variations in preference for L within Canada but not USA. Further studies to examine the reasons for these differences are warranted. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Aventis, Biomira, Ortho-Biotech, Pfizer, Pharmacia, Roche, YM Biosciences AstraZeneca, Aventis, Eli Lilly, Novartis, Pfizer, Pharmacia Novartis AstraZeneca, Aventis
Abstract 15241: Cardiac Troponin T, Natriuretic Peptide, and Long-term Risk of Acute Kidney Injury in the Community: The Atherosclerosis Risk in Communities Study
Authors: Yuhree Kim, Kunihiro Matsushita, Yingying Sang, Morgan Grams, Hicham Skali, Amil M Shah, Ron C Hoogeveen, Elizabeth Selvin, Scott D Solomon, Christie M Ballantyne, Josef Coresh
Journal: Circulation (2014)

Introduction:  Acute kidney injury (AKI) is an important clinical and public health issue, with a high rate of adverse outcomes. A few small studies demonstrate that cardiac troponin T (cTnT) and B-type natriuretic peptide (BNP) before surgery or revascularization predict incident AKI after those procedures. However, whether this association holds in a long term among the general population is unknown.   Hypothesis:  High-sensitivity cTnT (hs-cTnT) and N-terminal pro-BNP (NT-proBNP) are associated with incident AKI in the general population, even among those without cardiovascular disease (CVD) or chronic kidney disease (CKD) at baseline.   Methods:  We studied 10,733 ARIC participants aged 53-75 years, without kidney failure at baseline. We used Cox proportional hazards models to estimate hazard ratios (HRs) of incident AKI (hospitalizations or deaths with ICD codes of AKI) by five categories of plasma hs-cTnT and NT-proBNP (divided at 32th, 57th, 77th, and 91th percentile based on clinical thresholds of hs-cTnT for fair comparison of two markers).   Results:  During a median follow-up of 13 years, there were 796 AKI events. hs-cTnT and NT-proBNP were significantly associated with AKI risk, independently of each other and potential confounders including kidney function and albuminuria (Model 3 in Table). Even categories 2-4 of hs-cTnT and NT-proBNP below their clinical cutpoints reached statistical significance. The associations were consistent among individuals without CVD (HR for category 5 vs. 1, 3.17 [2.28-4.40] for hs-cTnT and 2.60 [1.89-3.56] for NT-proBNP) or those without CKD at baseline (3.25 [2.34-4.52] and 3.52 [2.60-4.77], respectively).   Conclusions:  hs-cTnT and NT-proBNP were independently associated with long-term risk of AKI in the community. These cardiac markers attract attention for cardiovascular prediction in the general population and may also provide useful information on the risk of AKI, which can also occur in the outpatient setting.
Optotypes Consisting of Test-Letters and Pictographs for Measuring the Acuteness of Vision.
Authors: John Green, A. E. Ewing
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Irradiated haploidetical donor lymphocytes: A different approach to the immunotherapy of advanced solid tumors
Authors: J. T. Reynolds, D. Reinke, S. Weiler
Journal: Journal of Clinical Oncology (2004)

2573 Background:This is a pilot study to determine the practicality of a new form of immunotherapy. The basic concept of this treatment is to grow cytotoxic T-cells and helper T-cells against the tumor in the patients themselves rather than in the laboratory. Standard chemotherapy is used to generate the tumor antigen, as the tumor cells undergo apoptosis. HLA-haploidentical or closer donor mononuclear cells are given weekly to activate antigen processing and presenting, bypass immune tolerance and supply temporary NK, dendritic and helper cell activity. These cells are irradiated to prevent GVHD. IL-2 is used as a T-cell growth factor. The treatment is based on a murine leukemia model. Methods:All patients had painful bulky heavily pre-treated cancer, rapidly progressive despite salvage therapy. Treatment consisted of intravenous VP-16 100 mg/m2/d plus cyclosporine 1 mg/kg/d for three days followed by GM-CSF 500 μgr/d s.q. for 5 days. 5x107/kg haploidentical donor lymphocytes (DLI) are then donated by a relative and given to the patient weekly for 10 weeks. DLI are irradiated with 750 cGy to prevent GVHD. IL-2 is also given s.q. three times a week at a starting dose of 10x106 IU/m2. Results:Patients with clear cell sarcoma, colon and small lung cancer have been enrolled. Approximately 5x107/kg mononuclear cells may be easily collected weekly from a close relative of the patient. No GVHD has been encountered. A large delayed type hypersensitivity (DTH) reaction occurs at the site of IL-2 injection. Clinical responses occurred in all patients, narcotics were stopped and two patients returned to work. Tumors markers were stable or imaging showed a mixed response. All patients progressed after DLI were discontinued or temporarily if a new donor other than the first was substituted. The patient with lung cancer is again in clinical remission with further weekly IL-2 and chemotherapy and an even larger DTH reaction. Conclusions:Weekly irradiated DLI at a dose of 5x107/kg/wk with IL-2 is a workable form of immunotherapy. This dose appears to be tolerated by patients and donors. Despite advanced solid tumors, temporary responses were seen in all patients. No significant financial relationships to disclose.
Achieving Door-to-Balloon Times That Meet Quality Guidelines
Authors: Elizabeth H. Bradley, Sarah A. Roumanis, Martha J. Radford, Tashonna R. Webster, Robert L. McNamara, Jennifer A. Mattera, Barbara A. Barton, David N. Berg, Edward L. Portnay, Harry Moscovitz, Janet Parkosewich, Eric S. Holmboe, Martha Blaney, Harlan M. Krumholz
Journal: Journal of the American College of Cardiology (2005)
Conference urges further consultation on NICE diabetes guidance
Authors: N. Hawkes
Journal: BMJ (2015)

Draft guidelines issued by the National Institute for Health and Care Excellence (NICE) for the treatment of type 2 diabetes are a recipe for failure, a Westminster Health Forum seminar was told on 10 June.

The draft guidelines included drugs that should not be offered routinely, they excluded others that NICE has previously found to be cost effective, and they prescribed an overly rigid sequence rather than allowing treatment to be tailored to individual cases, said Lisa Anson, president of AstraZeneca UK/Ireland. After widespread criticism of the draft guidance NICE has said that substantial changes have been made, but Anson pleaded for the revised version to be made the subject of renewed consultation to make sure …
Abstract 11751: Multiple Mechanisms Are Involved in Enhanced Endothelium-Derived Hyperpolarizing Factor(EDHF)-Mediated Responses in Microvessels in Mice -A Clue for Novel Strategy for Vascular Protection
Authors: Junko Ohashi, Ayuko Sawada, Aya Takaki, Kazuki Noda, Sota Nakajima, Hiroaki Shimokawa
Journal: Circulation (2011)

Background: Endothelium-derived hyperpolarizing factor (EDHF) plays an important role in organ protection by modulating vascular tone, especially in microvessels. We have demonstrated in animals an...
Standards and Tests for Reagent Chemicals.
Authors: Benjamin Lindley Murray
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die Wechselwirkungen der Blutdrűsen.
Authors: Erich Leschke
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathophysiology of Depression
Authors: Akira Tanabe, Soichiro Nomura
Journal: JAMA (1963)

Neurobiological findings of depression are reviewed in this paper. Modern neurobiological methods have revealed pathophysiological mechanism associated with depression. Monoamine hypothesis, which was advocated in the 1950's, emphasizes that the deficiency of monoamine neurotransmitters bring about depressive symptoms. This theory played an important role in promoting the development of new antidepressants, but some inconsistent findings were pointed out concerning this theory. Neuroendocrine studies have revealed the hypothalamic-pituitary-adrenal (HPA) axis dysfunctions in depressive patients, and increased activity of HPA axis are considered as state marker of depression. Morphological changes of hippocampus, polymorphism of serotonin transporter gene, and down regulation of neurotrophin are also discussed in this review.