tbuckley/cabot-search huggingface dataset:
Abstract 12808: Transendocardial Cell Injection is Not Superior to Intracoronary Infusion in a Porcine Model of Chronic Ischemic Heart Disease: A Randomized Study on Efficiency Using Nuclear Imaging
Authors: Tycho I Van der Spoel, Krijn R Vrijsen, Stefan Koudstaal, Joost P Sluijter, Frank F Nijsen, John Bemelmans, Imo E Hoefer, Maarten-Jan M Cramer, Pieter A Doevendans, Eric Van Belle, Steven A Chamuleau
Journal: Circulation (2011)

Introduction: Stem cell therapy is a new strategy for chronic ischemic heart disease in patients, however, no consensus exists on the most optimal delivery strategy. Hypothesis: This randomized study was designed to assess cell delivery efficiency of intracoronary (IC), transendocardial (TE) and surgical delivery in a chronic pig model of ischemia-reperfusion injury. Methods: Twenty-one animals underwent delivery of 107 autologous Indium-oxine labeled bone marrow-derived mesenchymal stem cells (MSC) 4 weeks after infarction and were randomized to 1 of 3 groups (n=7 each group): IC, TE using electromechanical mapping guidance (NOGA) or surgical delivery. Primary endpoint was defined as percentage (%) of injected dose per organ and assessed by in vivo gamma-emission counting. Results: No significant difference in hemodynamics was observed. Troponin and intracoronary flow (Thrombolysis in Myocardial Infarction score) did not differ between the percutaneous groups. Blinded endpoint analysis showed no signific...
Clinical Approach to Endocrine Problems in Children.
Authors: Matthew M. Steiner
Journal: Annals of Internal Medicine (1971)

master-mind, one thinks, have boiled down the meat into a single, palatable dish?But here these forebodings would be quite unjustified.Twenty-six distinguished representatives from thirteen countries, including professors of various disciplines, administrators, senior nursing officers and sanitary engineers, met in Istanbul in June 1970 under the auspices of Ciba to discuss the praiseworthy but not very 'die on the barricades' theme of teamwork for world health.Nevertheless all the papers were useful, there was very little overlapping -the built-in defect of sym- posiaand some contributions were exciting and broke new ground.Besides descriptions of new team services on a national basis, e.g.Professor N H Fi §ek's account of the 'socialized' rural
Cardiac release of urocortin is independent from the occurrence of irreversible myocardial damage in the intact rat heart exposed to ischemia/reperfusion injury: A potential clinical marker of sublethal myocardial ischemia?
Authors: C. A. Chen-Scarabelli, R. Angeles, Z. Allebban, R. Ama, J. Abboud, P. Townsend, H. Rosman, R. McCauley, J. Gardin, T. M. Scarabelli
Journal: Circulation (2005)
Abstract 20072: Intrapericardial Triamcinolone in Radiation Induced and Intrapericardial Cisplatin Treatment in Malignant Pericardial Effusion Prevent Recurrence Effectively
Authors: Bernhard Maisch, Sabine Pankuweit, Konstanin Karatolios, Roland Moll, Arsen Ristic
Journal: Circulation (2010)

Background:  The treatment of malignant (MPE) vs. radiation induced pericardial effusion (RPE) in patients with or after diagnosis and treatment of their respective neoplastic disease differs considerably.   Methods:  We identified 42 pts with MPE (69% m, mean age 58,8+13,2 y) and 15 pts (66% fem, mean age 54,7+12.4 y) with RPE by analyzing the pericardial fluid and the pericardioscopically guided epi- and pericardial biopsy for malignant cells or infiltrates. In the case of nonmalignant effusions we excluded other causes than previous radiotherapy in the last 20 years by immunohistology and PCR for cardiotropic microbial agents.   Results:  In MPE we identified: lung cancer in 52,4%; breast cancer in 19,0%; Hodgkin9s disease in 4,8%; esophageal cancer in 2,4%; mesothelioma in 2,4%; colon cancer in 4,8%; and undifferentiated cancer of unknown origin in 14,2%. In RPE 11 pts had previous breast cancer, 4 pts bronchus carcinoma. MPEs were treated with intrapericardial cisplatin (single instillation of 30 mg / m 2  for 24 h) in addition to the tumor-specific systemic chemotherapy. It prevented recurrence of pericardial effusion during the first 3 months of the follow-up in 92,8%, and after 6 months in 83,3% of the pts. Lung cancer patients had fewer effusion relapses at the 6 months follow-up (4.5%) than breast cancer patients (37.5%)(P 2  triamcinolonacetate (Volon A) intrapericardially followed by 6 months oral treatment with colchicin (2–3x0.5 mg). Recurrence of effusion was prevented in 13 of 15 cases (86.6%) after 3 and 6 months.   Conclusions:  1) Intrapericardial treatment with cisplatin prevents recurrences of MPE effectively. The treatment was more successful in lung than in breast cancer pts. 2) In RPE sclerosing and anti-inflammatory treatment with triamcinolonacete was equally effective.
Aspirin prophylaxis (100 mg daily) does not improve cardiovascular outcomes compared to placebo in asymptomatic individuals with incidental low-ankle brachial index
Authors: Marlene, Grenon, Michael, Conte, 向攀
Journal: BMJ (2011)

外周动脉疾病（Peripheral arterial disease，PAD）在全球患者众多，此类人群心血管事件发病率和病死率增加3～6倍。PAD被认为是心血管事件的高危因素，而心脑血管事件是致死的首要原因。
Adenosine Triphosphatases of Rat Pancreatic Islets
Authors: Seymour R. Levin, Barry G. Kasson, June F. Driessen
Journal: Journal of Clinical Investigation (1978)

Electrolyte fluxes are fundamental to normal endocrine pancreatic function. Adenosine triphosphatases (ATPases) are enzyme systems believed to modulate electrolyte movements across membranes in a number of cell types. This study was undertaken to measure cation-dependent ATPases of rat pancreatic islets. In addition, we compared effects of substances which influence endocrine pancreatic function upon ATPases in homogenates of islets and kidney, the latter being a tissue which would not be expected to have a stimulus-secretion response to substances which activate islets.
Benzodiazepine-associated emergencies in Toronto
Authors: U Busto, H L Kaplan, E M Sellers
Journal: American Journal of Psychiatry (1980)

In a prospective study of drug overdose patients admitted to emergency rooms of 21 Toronto hospitals, 39% said they had taken a benzodiazepine. Benzodiazepines were used more frequently by females than males and by suburban than core hospital patients. Patients who overdosed on benzodiazepines were admitted to the hospital less frequently and arrived with less disturbance of consciousness than those who had used other drugs. Patterns of prescription in Ontario and patterns of overdose in Metropolitan Toronto were highly correlated.
Abstract 5083: Body Composition, Cardiorespiratory Fitness and Low-Grade Inflammation in Middle-Aged Men and Women
Authors: Benoit J Arsenault, Amelie Cartier, Melanie Cote, Isabelle Lemieux, Angelo Tremblay, Claude Bouchard, Louis Perusse, Jean-Pierre Despres
Journal: Circulation (2008)

Background: Although low levels of cardiorespiratory fitness (CRF) and obesity are often associated with a deteriorated cardiometabolic risk profile including low-grade inflammation, the respective contributions of specific indices of body fat distribution and CRF to variation of inflammatory markers remains uncertain. We therefore sought to determine the respective contributions of visceral adipose tissue (VAT) accumulation and CRF to variation of inflammatory markers in middle-aged men and women. Methods and Results: A complete lipoprotein-lipid profile and circulating levels of inflammatory markers such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and adiponectin were obtained and in a sample of healthy men (n=120) and women (n=152) covering a wide range of obesity values. VAT accumulation was measured by computed tomography and CRF levels were measured by a progressive submaximal physical working capacity test. In both men and women, VAT was positively associated with CRP and IL-6 levels (r≥0.35, p&lt;0.0001), negatively associated with adiponectin (r≤ −0.29, p≤0.0003), after adjusting for CRF. After adjusting for VAT, CRF was not associated with variation in inflammatory markers in women and only with adiponectin in men (r= −0.20, p=0.03). An inflammation score was developed based on the sex-specific 50 th percentile values of each inflammatory marker (0 or 1) which yielded a score ranging from 0 (low) to 4 (high). Participants who scored 0, 1 or 2 were considered as having a low score and participants who scored 3 or 4 had an elevated inflammation score. In participants with low VAT (&lt;130cm 2 for men and &lt;100cm 2 for women), the prevalence of participants with an elevated inflammation score was of 23.9% and of 28.0%, respectively for participants with high and low CRF, whereas in participants with an elevated VAT accumulation, the prevalence of an elevated inflammation score was of 60.0% and of 61.7%, respectively for high and low CRF. Conclusions: These results suggest that the inflammatory state associated with low CRF is largely attributable to the increased VAT accumulation often observed in poorly fit individuals.
Behçet's Disease: Basic and Clinical Aspects
Authors: J. Desmond O'Duffy, Emre Kokmen
Journal: Annals of Internal Medicine (1992)

Ninety-three papers presented at the Fifth International Conference on Behcets' Disease held at the Mayo Clinic in Rochester, Minnesota, September 1989, are organized within four sections: diagnostic criteria and epidemiology; clinical manifestations ocular,, neurological, vascular and pulmonary, cu
Block Anesthesia and Allied Subjects. With Special Chapters on the Maxillary Sinus, the Tonsils, and Neuralgias of the Nervus Trigeminus. For Oral Surgeons, Dentists, Laryngologists, Rhinologists, Otologists and Students.
Authors: Arthur Ervin Smith
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preclinical activity of combinations of capecitabine (C), docetaxel (D), and trastuzumab (T) in a breast cancer xenograft model
Authors: K. Kolinsky, Y. Zhang, C. Moisa, U. Dugan, K. Packman, B. Higgins
Journal: Journal of Clinical Oncology (2007)

13508 Background: C is highly active, well tolerated, and extends survival when added to D in pretreated metastatic BC. We report preclinical data on CD doublets ± T, a humanized monoclonal antibody against HER2-neu, in the KPL-4 human BC xenograft model (ER-, HER2+). Methods: Initially, the antitumor activity of optimal dose (OD) and ½ OD C and D monotherapy was evaluated alongside ½ OD C + ½ OD D or ½ OD C + OD D. Data showed ½ OD C + OD D was toxic; thus, OD C + OD D was not considered further. The OD C + ½ OD D doublet and the optimal doublet from the initial study (½ OD C + ½ OD D) were tested ± T in this HER2+ model. Results: In the initial study, tumor response (TR) and increased life span (ILS) were significantly better for ½ OD C + ½ OD D than for ½ OD C, OD C, ½ OD D, or OD D. In the follow-up study, TR and ILS were not significantly different in the ½ OD C + ½ OD D and OD C + ½ OD D doublets but were better with the addition of T to each doublet. In comparing triplicates, TR was not statistically different, and survival was equivalent at this point because of complete responses (CRs) in both groups. At day 127, there were 2/10 CRs in the ½ OD C + ½ OD D + T group (ILS=267%) vs 6/10 CRs in the OD C + ½ OD D + T group (ILS&gt;370%, ongoing). Conclusions: Adding T to the non-toxic CD doublets increases TR and ILS. Thus far, results argue for the most dense dose of C in triplicate combinations for sustaining CRs. However, since CRs are present in both triplicate groups of limited sample size (n=10), an overall survival difference is not yet significant. The data support clinical testing of CD doublets with or without T, which is ongoing in the neoadjuvant setting in HER2- and HER2+ BC patients, respectively. [Table: see text] No significant financial relationships to disclose.
AMEBIC GRANULOMA OF THE RECTUM
Authors: Matthew W. Perry
Journal: JAMA (1952)

Reports of amebic granuloma in general, and of amebic granuloma of the rectum in particular, are relatively rare. Accordingly, the following case of amebic granuloma of the rectum is reported. <h3>REPORT OF A CASE</h3> D. B. F., a 49-year-old man was seen Aug. 3, 1949. He had recently returned from a trip to the Orient. He stated that he had first had symptoms of diarrhea in early July, while in Bagdad. His bowel looseness lasted a short while and then improved briefly. From then on he had recurrent spells of mild diarrhea with lower abdominal cramping pain. He had first observed the passage of bloody mucus only four days before consulting me. On reaching this country he reported to the Division of Infectious Diseases of the National Institutes of Health, where his fecal material was found teeming with Endameba histolytica. A physical examination revealed a liver palpable 7 cm. below
The Need for Emotional Data in the Medical History
Authors: John Favill
Journal: Annals of Internal Medicine (1929)

Article1 November 1929The Need for Emotional Data in the Medical HistoryJOHN FAVILL, A.B., M.D., F.A.C.P.JOHN FAVILL, A.B., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-5-462 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis paper is a neurologic plea to internists to make, as a routine proceedure in all medical histories except those of acute infections, some definite inquiry about possible disturbing emotional factors. By the latter I of course do not mean so-called unconscious matters which belong to the orthodox psychoanalyst. Neither do I suggest any intensive "third degree" probing by a junior intern who takes histories. But I am certain that many cases could be saved much delay and expense were the opportunity offered them early to state the existence of painful memories, present dilemmas or fears regarding the future.Two...1 Woodyatt RT. Jour. A. M. A., Vol. 89, No. 13, Sept. 24, 1927, P. 1013. CrossrefGoogle Scholar2 Wooley PG. C. V. Mosby Co., St. Louis, 1916, P. 29. Google Scholar3 Foster NB. W. B. Saunders Co., Philadelphia and London, 1924. Google Scholar4 Corscaden JA. Paul B. Hoeber, New York, 1926, PP. 28 and 52. Google Scholar5 Kirby GH. "Guides for History Taking and Clinical Examination of Psychiatric Cases." N. Y. State Hospital Commission, Albany, 1921. Google Scholar6 Dock G. Geo. Wahr. Ann Arbor, Mich., 1921, P. 34. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Written for the meeting of the American College of Physicians, Boston, Mass., April 10, 1929, but not read. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1929Volume 3, Issue 5Page: 462-466KeywordsEmotionsFearForecastingMemory ePublished: 1 December 2008 Issue Published: 1 November 1929 PDF downloadLoading ...
Medical Radiation Biology.
Authors: Friedrich Philipp Ellinger
Journal: Annals of Internal Medicine (1973)

This authoritative volume should serve essentially as an excellent source of reference for all those concerned with radiation and its effects. The author, undertaking an ambitious project, has systematically recorded the available information in a concise logical presentation. In the first part of the book, the fundamental principles or radiation biology are set forth. The remainder of the book is then subdivided into discussions of the biology of ionizing radiation, utlraviolet radiation, and visible and infrared radiation, with emphasis on medical significance. Throughout, the author is careful to point out which information is well documented and which is purely theoretical and also which is derived from animal study as distinct from human studies. There is a complete table of contents, which facilitates reference and helps somewhat to make up for the lack of an index. One-fourth of the book is devoted to a comprehensive bibliography of more than 5000 references.
The Use of Death-Rates as a Measure of Hygienic Conditions.
Authors: John Brownlee
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nick Black: Looking for a post at Arsenal
Authors: Nick Black
Journal: BMJ (2014)

Looking for a post at ArsenalIn the next of its series asking the movers and shakers of the medical world about work, life, and less serious matters, the BMJ spoke to the champion of PROMs (patient reported outcome measures) What was your earliest ambition?To be a film director (preferably Swedish, French, or Italian). Who has been your biggest inspiration?Phil Strong, one of the leading medical sociologists of his generation, who, despite his early death at 49, offered me a unique and challenging perspective that has influenced much of my thinking. What was the worst mistake of your career?It might prove to be answering these questions.I regret none of the knight's moves I've made, and I would encourage people not to be dissuaded from pursuing less predictable options. What was your best career move?Spending three years as a lecturer at the Open University.Working intensively with a biologist, economist, and sociologist, it
Prevention of Disease and Care of the Sick: How to Keep Well and What to do in Case of Sudden Illness.
Authors: W. G. Stimpson, M. H. Foster
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adherence to medication in patients with psoriasis: a systematic review
Authors: Rachael Thorneloe, Christine Bundy, Christopher Em Griffiths, Darren Ashcroft, Lis Cordingley
Journal: British Journal of Dermatology (2012)

Psoriasis is associated with considerable physical and psychological morbidity. Optimal use of psoriasis treatments can limit the physical manifestations of psoriasis and help improve quality of life, but non-adherence is common. Smoking, obesity and excessive alcohol consumption are prevalent in this population. A systematic review of adherence to medication and recommendations for lifestyle change in psoriasis was undertaken, with a critical appraisal of the quality of selected studies. Electronic searches from inception to March 2012 (PubMed, Web of Science and EMBASE) were conducted. Twenty nine studies were included, however, none examined adherence to advice about lifestyle change. Studies using a dichotomous classification of adherence tended to report sub-optimal adherence, with 21.6% - 66.6% of patients classed as adherent. No consistent pattern of results emerged for socio-demographic, disease and lifestyle factors as determinants of adherence. However, some treatment factors were associated with adherence. Whilst mixed findings were reported for quality of life as a determinant of adherence, psychological factors (psychological distress and patient satisfaction with care / therapy) were associated with adherence. Only tentative conclusions can be made for determinants of adherence because the methodological quality of many of the included studies limits conclusions. There is a need for improved research quality and reporting in this area and this review provides a platform from which future research within this area should progress with suggested research recommendations.
Disease of the Pancreas. Its Cause and Nature.
Authors: Eugene Lindsay Opie
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal