tbuckley/cabot-search huggingface dataset:
Targeted Anti-Cancer Therapy: Co-Delivery of VEGF siRNA and Phenethyl isothiocyanate (PEITC) via cRGD-Modified Lipid Nanoparticles for Enhanced Anti-Angiogenic Efficacy
Authors: Bao Li, Haoran Niu, Xiaoyun Zhao, Xiaoyu Huang, Yu Ding, Ke Dang, Tianzhi Yang, Yongfeng Chen, Jizhuang Ma, Xiaohong Liu, Keda Zhang, Huichao Xie, Pingtian Ding
Journal: Asian Journal of Pharmaceutical Sciences (2024)

Anti-tumor angiogenesis therapy, targeting the suppression of blood vessel growth in tumors, presents a potent approach in the battle against cancer. Traditional therapies have primarily concentrated on single-target techniques, with a specific emphasis on targeting the vascular endothelial growth factor, but have not reached ideal therapeutic efficacy. In response to this issue, our study introduced a novel nanoparticle system known as CS-siRNA/PEITC&L-cRGD NPs. These chitosan-based nanoparticles have been recognized for their excellent biocompatibility and ability to deliver genes. To enhance their targeted delivery capability, they were combined with a cyclic RGD peptide (cRGD). Targeted co-delivery of gene and chemotherapeutic agents was achieved through the use of a negatively charged lipid shell and cRGD, which possesses high affinity for integrin α
Etiological agent and clinical characteristics of haemorrhagic fever with renal syndrome in the southern Republic of Korea: A genomic surveillance study
Authors: Sara P. Prayitno, Augustine Natasha, Seonghyeon Lee, Choon-Mee Kim, You Mi Lee, Kyungmin Park, Jongwoo Kim, Seong-Gyu Kim, Jieun Park, Shivani Rajoriya, Gustavo Palacios, Yeonsu Oh, Jin-Won Song, Dong-Min Kim, Won-Keun Kim
Journal: Clinical Microbiology and Infection (2024)

High incidences of haemorrhagic fever with renal syndrome (HFRS) have been reported in the southern Republic of Korea (ROK). A distinct southern genotype of Orthohantavirus hantanense (HTNV) was identified in Apodemus agrarius chejuensis on Jeju Island. However, its association with HFRS cases in southern ROK remains elusive. We investigated the potential of the southern HTNV genotype as an etiological agent of HFRS.
Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies
Authors: Manu Shankar-Hari, Thierry Calandra, Miguel P Soares, Michael Bauer, W Joost Wiersinga, Hallie C Prescott, Julian C Knight, Kenneth J Baillie, Lieuwe D J Bos, Lennie P G Derde, Simon Finfer, Richard S Hotchkiss, John Marshall, Peter J M Openshaw, Christopher W Seymour, Fabienne Venet, Jean-Louis Vincent, Christophe Le Tourneau, Anke H Maitland-van der Zee, Iain B McInnes, Tom van der Poll
Journal: The Lancet Respiratory Medicine (2024)
Efficacy and Safety of Vonoprazan-Amoxicillin Dual Regimen With Varying Dose and Duration for Helicobacter pylori Eradication: A Multicenter, Prospective, Randomized Study
Authors: Xiang Peng, Jia-Yin Yao, Yu-qian Ma, Guo-hua Li, Huang-wei Chen, Yu Wan, Dong-sheng Liang, Min Zhang, Min Zhi
Journal: Clinical Gastroenterology and Hepatology (2024)

Background & AimsPrevious studies confirm vonoprazan-amoxicillin effectiveness for Helicobacter pylori. This study aims to investigate vonoprazan with varying amoxicillin dose and duration.MethodsThis multicenter, prospective, randomized controlled, noninferiority trial enrolled patients with treatment naive H pylori infection from 5 clinical centers. Eligible participants were randomly assigned to H-VA-10 (vonoprazan 20 mg twice a day (b.i.d.) + amoxicillin 750 mg 4 times a day, 10 days), L-VA-10 (vonoprazan 20 mg b.i.d. + amoxicillin 1000 mg b.i.d, 10 days), and H-VA-14 (vonoprazan 20 mg b.i.d + amoxicillin 750 mg 4 times a day, 14 days) in a 1:1:1 ratio. The eradication rate was assessed using the 13C-urea breath test at least 28 days after treatment.ResultsOf the 623 eligible patients, 516 patients were randomized. In both the intention-to-treat and per-protocol analyses, eradication rates were comparable between H-VA-10 and H-VA-14 groups (86.6% vs 89.5% and 90.9% vs 94.5%, P = .021 and .013 for noninferiority, respectively). However, eradication rates were significantly lower in the L-VA-10 group than the H-VA-14 group (79.7% vs 89.5% and 82.0% vs 94.5%, P = .488 and .759, respectively). Rates of study withdrawal, loss to follow-up, and adverse events were similar across study groups.ConclusionsH-VA-10 and H-VA-14 regimens provide satisfactory efficacy for H pylori infection, and the L-VA-10 regimen was inferior. ClinicalTrials.gov number: NCT05719831.
Dextrose-containing fluids causing false-positive serum galactomannan: a case-control study and interrupted time series analysis
Authors: Raeseok Lee, In Young Yoo, Eun-Jee Oh, Ae Ran Choi, Dukhee Nho, Sung-Yeon Cho, Jongin Lee, Hye Lim Ahn, Yeon-Joon Park, Dong-Gun Lee
Journal: Clinical Microbiology and Infection (2024)

ObjectivesThis study aimed to identify the cause of false-positive serum Aspergillus antigen galactomannan (GM) results in our centre.MethodsWe performed a case-control study aiming to elucidate the factors associated with false-positive GM results. Independent risk factors for false-positive GM were evaluated through a multivariable regression analysis. An interrupted time series analysis was used to evaluate the effectiveness of an intervention removing the identified factors.ResultsAmong 568 patients tested, GM was positive in 130 patients of whom 97 had false-positive GM (cases). These were compared with 427 patients with true-negative GM (controls). Administration of dextrose-containing fluids within 6 days before GM testing was an independent predictor for false-positive GM results (adjusted odds ratio [aOR], 18.60; 95% CI, 8.95–38.66. An analysis of GM presence in different dextrose-containing fluids revealed positivity in 34.8% (8 of 23) (manufacturer A) and 33.3% (5 of 15) (manufacturer B) of the samples. Investigation of the manufacturing process revealed that the saccharification process employed enzymes derived from Aspergillus niger. After identifying the root cause of false positivity, GM-containing dextrose fluid use was restricted. Interrupted time series analysis showed an immediate reduction of GM false-positivity (−6.5% per week, p = 0.045) and a declining trend (−0.33% per week, p = 0.005) postintervention.ConclusionsAdministering dextrose-containing fluids was the primary factor causing false-positive serum Aspergillus antigen GM assay results. Our investigation led to a modification of the manufacturing process of the dextrose-containing fluids.
Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages
Authors: Fengbo Yang, Xiaoli Jia, Chao Hua, Feifan Zhou, Jianing Hua, Yuting Ji, Peng Zhao, Quan Yuan, Malcolm Xing, Guozhong Lyu
Journal: Bioactive Materials (2024)

Nature makes the most beautiful solution to involuted problems. Among them, the parallel tubular structures are capable of transporting fluid quickly in plant trunks and leaf stems, which demonstrate an ingenious evolutionary design. This study develops a mini-thermoelectric semiconductor P–N module to create gradient and parallel channeled hydrogels. The modules decrease quickly the temperature of polymer solution from 20 °C to −20 °C within 5 min. In addition to the exceptional liquid absorption rate, the foams exhibited shape memory mechanics. Our mini device universally makes the inspired structure in such as chitosan, gelatin, alginate and polyvinyl alcohol. Non-compressible hemorrhages are the primary cause of death in emergency. The rapid liquid absorption leads to fast activation of coagulation, which provides an efficient strategy for hemostasis management. We demonstrated this by using our semiconductor modules on collagen-kaolin parallel channel foams with their high porosity (96.43%) and rapid expansion rate (2934%). They absorb liquid with 37.25 times of the own weight, show 46.5-fold liquid absorption speed and 24-fold of blood compared with random porous foams. These superior properties lead to strong hemostatic performance in vitro and in vivo.
Cholesterol metabolism: physiological regulation and diseases
Authors: Jiarui Guo, Silong Chen, Ying Zhang, Jinxia Liu, Luyang Jiang, Lidan Hu, Ke Yao, Yibo Yu, Xiangjun Chen
Journal: MedComm (2024)

Cholesterol homeostasis is crucial for cellular and systemic function. The disorder of cholesterol metabolism not only accelerates the onset of cardiovascular disease (CVD) but is also the fundamental cause of other ailments. The regulation of cholesterol metabolism in the human is an extremely complex process. Due to the dynamic balance between cholesterol synthesis, intake, efflux and storage, cholesterol metabolism generally remains secure. Disruption of any of these links is likely to have adverse effects on the body. At present, increasing evidence suggests that abnormal cholesterol metabolism is closely related to various systemic diseases. However, the exact mechanism by which cholesterol metabolism contributes to disease pathogenesis remains unclear, and there are still unknown factors. In this review, we outline the metabolic process of cholesterol in the human body, especially reverse cholesterol transport (RCT). Then, we discuss separately the impact of abnormal cholesterol metabolism on common diseases and potential therapeutic targets for each disease, including CVD, tumors, neurological diseases, and immune system diseases. At the end of this review, we focus on the effect of cholesterol metabolism on eye diseases. In short, we hope to provide more new ideas for the pathogenesis and treatment of diseases from the perspective of cholesterol.
Safety and pharmacokinetics of ONC201 (dordaviprone) administered two consecutive days per week in pediatric patients with H3 K27M-mutant glioma
Authors: Yazmin Odia, Carl Koschmann, Nicholas A Vitanza, Peter de Blank, Dolly Aguilera, Jeffrey Allen, Doured Daghistani, Matthew Hall, Ziad Khatib, Cassie Kline, Tobey MacDonald, Sabine Mueller, Shamia L Faison, Joshua E Allen, Odin J Naderer, Samuel C Ramage, Rohinton S Tarapore, Susan Lynne McGovern, Soumen Khatua, Wafik Zaky, Sharon L Gardner
Journal: Neuro-Oncology (2024)

Abstract Background This study evaluated the safety and pharmacokinetics (PK) of oral ONC201 administered twice-weekly on consecutive days (D1D2) in pediatric patients with newly diagnosed DIPG and/or recurrent/refractory H3 K27M glioma. Methods This phase 1 dose-escalation and expansion study included pediatric patients with H3 K27M-mutant glioma and/or DIPG following ≥1 line of therapy (NCT03416530). ONC201 was administered D1D2 at 3 dose levels (DLs; −1, 1, and 2). The actual administered dose within DLs was dependent on weight. Safety was assessed in all DLs; PK analysis was conducted in DL2. Patients receiving once-weekly ONC201 (D1) served as a PK comparator. Results Twelve patients received D1D2 ONC201 (DL1, n = 3; DL1, n = 3; DL2, n = 6); no dose-limiting toxicities or grade ≥3 treatment-related adverse events occurred. PK analyses at DL2 (D1-250 mg, n = 3; D1-625 mg, n = 3; D1D2-250 mg, n = 2; D1D2-625 mg, n = 2) demonstrated variability in Cmax, AUC0–24, and AUC0–48, with comparable exposures across weight groups. No accumulation occurred with D1D2 dosing; the majority of ONC201 cleared before administration of the second dose. Cmax was variable between groups but did not appear to increase with D1D2 dosing. AUC0–48 was greater with D1D2 than once-weekly. Conclusions ONC201 given D1D2 was well tolerated at all DLs and associated with greater AUC0–48.
A CD38-directed, single-chain T-cell engager targets leukemia stem cells through IFN-γ–induced CD38 expression
Authors: Mariam Murtadha, Miso Park, Yinghui Zhu, Enrico Caserta, Ottavio Napolitano, Theophilus Tandoh, Milad Moloudizargari, Alex Pozhitkov, Mahmoud Singer, Ada Alice Dona, Hawa Vahed, Asaul Gonzalez, Kevin Ly, Ching Ouyang, James F. Sanchez, Lokesh Nigam, Amanda Duplan, Arnab Chowdhury, Lucy Ghoda, Ling Li, Bin Zhang, Amrita Krishnan, Guido Marcucci, John C. Williams, Flavia Pichiorri
Journal: Blood (2024)
SUGAR: Spherical ultrafast graph attention framework for cortical surface registration
Authors: Jianxun Ren, Ning An, Youjia Zhang, Danyang Wang, Zhenyu Sun, Cong Lin, Weigang Cui, Weiwei Wang, Ying Zhou, Wei Zhang, Qingyu Hu, Ping Zhang, Dan Hu, Danhong Wang, Hesheng Liu
Journal: Medical Image Analysis (2024)

Cortical surface registration plays a crucial role in aligning cortical functional and anatomical features across individuals. However, conventional registration algorithms are computationally inefficient. Recently, learning-based registration algorithms have emerged as a promising solution, significantly improving processing efficiency. Nonetheless, there remains a gap in the development of a learning-based method that exceeds the state-of-the-art conventional methods simultaneously in computational efficiency, registration accuracy, and distortion control, despite the theoretically greater representational capabilities of deep learning approaches. To address the challenge, we present SUGAR, a unified unsupervised deep-learning framework for both rigid and non-rigid registration. SUGAR incorporates a U-Net-based spherical graph attention network and leverages the Euler angle representation for deformation. In addition to the similarity loss, we introduce fold and multiple distortion losses to preserve topology and minimize various types of distortions. Furthermore, we propose a data augmentation strategy specifically tailored for spherical surface registration to enhance the registration performance. Through extensive evaluation involving over 10,000 scans from 7 diverse datasets, we showed that our framework exhibits comparable or superior registration performance in accuracy, distortion, and test-retest reliability compared to conventional and learning-based methods. Additionally, SUGAR achieves remarkable sub-second processing times, offering a notable speed-up of approximately 12,000 times in registering 9,000 subjects from the UK Biobank dataset in just 32 min. This combination of high registration performance and accelerated processing time may greatly benefit large-scale neuroimaging studies.
Lung regeneration: diverse cell types and the therapeutic potential
Authors: Yutian Chen, Zhen Li, Gaili Ji, Shaochi Wang, Chunheng Mo, Bi‐Sen Ding
Journal: MedComm (2024)

Abstract Lung tissue has a certain regenerative ability and triggers repair procedures after injury. Under controllable conditions, lung tissue can restore normal structure and function. Disruptions in this process can lead to respiratory system failure and even death, causing substantial medical burden. The main types of respiratory diseases are chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and acute respiratory distress syndrome (ARDS). Multiple cells, such as lung epithelial cells, endothelial cells, fibroblasts, and immune cells, are involved in regulating the repair process after lung injury. Although the mechanism that regulates the process of lung repair has not been fully elucidated, clinical trials targeting different cells and signaling pathways have achieved some therapeutic effects in different respiratory diseases. In this review, we provide an overview of the cell type involved in the process of lung regeneration and repair, research models, and summarize molecular mechanisms involved in the regulation of lung regeneration and fibrosis. Moreover, we discuss the current clinical trials of stem cell therapy and pharmacological strategies for COPD, IPF, and ARDS treatment. This review provides a reference for further research on the molecular and cellular mechanisms of lung regeneration, drug development, and clinical trials.
Multichannel-optical imaging for in vivo evaluating the safety and therapeutic efficacy of stem cells in tumor model in terms of cell tropism, proliferation and NF-κB activity
Authors: Dehua Huang, Xue Yang, Zhao Peng, Hongqiang Yin, Yongyang Liu, Yejun Zhang, Chunyan Li, Guangcun Chen, Qiangbin Wang
Journal: Biomaterials (2024)
CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma
Authors: Peiyi Xie, Mincheng Yu, Bo Zhang, Qiang Yu, Yufei Zhao, Mengyuan Wu, Lei Jin, Jiuliang Yan, Binghai Zhou, Shuang Liu, Xiaoqiang Li, Chenhao Zhou, Xiaodong Zhu, Cheng Huang, Yongfeng Xu, Yongsheng Xiao, Jian Zhou, Jia Fan, Mien-Chie Hung, Qinghai Ye, Lei Guo, Hui Li
Journal: Journal of Hepatology (2024)
Identification of gaps in the performance of routine microscopy for the diagnosis of parasitic infections revealed by the Dutch laboratory quality assessment scheme
Authors: Marrit B. Boonstra, Rob Koelewijn, Eric A.T. Brienen, Kim Tassche-Borggreve, Laetitia M. Kortbeek, Theo G. Mank, Bert Mulder, Foekje Stelma, Lisette van Lieshout, Jaap J. van Hellemond
Journal: Clinical Microbiology and Infection (2024)
Racial/Ethnic Disparities in Pathologic Complete Response and Overall Survival in Patients With Triple-Negative Breast Cancer Treated With Neoadjuvant Chemotherapy
Authors: Hannah E. Woriax, Samantha M. Thomas, Jennifer K. Plichta, Laura H. Rosenberger, Astrid Botty van den Bruele, Akiko Chiba, E. Shelley Hwang, Maggie L. DiNome
Journal: Journal of Clinical Oncology (2024)

Black women have higher rates of death from triple-negative breast cancer (TNBC) than White women. We hypothesized that pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) and overall survival (OS) may vary by race/ethnicity in patients with TNBC.
TractGeoNet: A geometric deep learning framework for pointwise analysis of tract microstructure to predict language assessment performance
Authors: Yuqian Chen, Leo R. Zekelman, Chaoyi Zhang, Tengfei Xue, Yang Song, Nikos Makris, Yogesh Rathi, Alexandra J. Golby, Weidong Cai, Fan Zhang, Lauren J. O'Donnell
Journal: Medical Image Analysis (2024)
Assessment of Advanced Diagnostic Bronchoscopy Outcomes for Peripheral Lung Lesions: A Delphi Consensus Definition of Diagnostic Yield and Recommendations for Patient-centered Study Designs. An Official American Thoracic Society/American College of Chest Physicians Research Statement
Authors: Anne V. Gonzalez, Gerard A. Silvestri, Daniel A. Korevaar, Yaron B. Gesthalter, Nisha D. Almeida, Alex Chen, Chris R. Gilbert, Peter B. Illei, Neal Navani, Mary M. Pasquinelli, Nicholas J. Pastis, Catherine R. Sears, Samira Shojaee, Stephen B. Solomon, Daniel P. Steinfort, Fabien Maldonado, M. Patricia Rivera, Lonny B. Yarmus
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

Advanced diagnostic bronchoscopy targeting the lung periphery has developed at an accelerated pace over the last two decades, whereas evidence to support introduction of innovative technologies has been variable and deficient. A major gap relates to variable reporting of diagnostic yield, in addition to limited comparative studies.
Issues and Events
Journal: Diabetes Care (2024)

The American Diabetes Association's "Standards of Care in Diabetes" is based on a complete review of the relevant literature and is intended to provide clinicians, researchers, policymakers, and other interested individuals with the components of diabetes care, general treatment goals, and tools to evaluate the quality of care.The American Diabetes Association Professional Practice Committee updates the Standards of Care annually and strives to include discussion of emerging clinical considerations.
Chronic Myeloid Leukemia, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology
Authors: Neil P. Shah, Ravi Bhatia, Jessica K. Altman, Maria Amaya, Kebede H. Begna, Ellin Berman, Onyee Chan, Joan Clements, Robert H. Collins, Peter T. Curtin, Daniel J. DeAngelo, Michael Drazer, Lori Maness, Leland Metheny, Sanjay Mohan, Joseph O. Moore, Vivian Oehler, Keith Pratz, Iskra Pusic, Michal G. Rose, William Shomali, B. Douglas Smith, Michael Styler, Moshe Talpaz, Tiffany N. Tanaka, Srinivas Tantravahi, James Thompson, Steven Tsai, Jennifer Vaughn, Jeanna Welborn, David T. Yang, Hema Sundar, Kristina Gregory
Journal: Journal of the National Comprehensive Cancer Network (2024)

Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome resulting from a reciprocal translocation between chromosomes 9 and 22 [t9;22] that gives rise to a BCR::ABL1 fusion gene. CML occurs in 3 different phases (chronic, accelerated, and blast phase) and is usually diagnosed in the chronic phase in developed countries. Tyrosine kinase inhibitor (TKI) therapy is a highly effective treatment option for patients with chronic phase–CML. The primary goal of TKI therapy in patients with chronic phase–CML is to prevent disease progression to accelerated phase–CML or blast phase–CML. Discontinuation of TKI therapy with careful monitoring is feasible in selected patients. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of patients with chronic phase–CML.
Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism
Authors: Sheng Zhang, Yunkai Zhang, Xuewen Duan, Bo Wang, Zhenzhen Zhan
Journal: Circulation (2024)

Reparative macrophages play a crucial role in limiting excessive fibrosis and promoting cardiac repair after myocardial infarction (MI), highlighting the significance of enhancing their reparative phenotype for wound healing. Metabolic adaptation orchestrates the phenotypic transition of macrophages; however, the precise mechanisms governing metabolic reprogramming of cardiac reparative macrophages remain poorly understood. In this study, we investigated the role of NPM1 (nucleophosmin 1) in the metabolic and phenotypic shift of cardiac macrophages in the context of MI and explored the therapeutic effect of targeting NPM1 for ischemic tissue repair.
HBV integrations reshaping genomic structures promote hepatocellular carcinoma
Authors: Zhaoyang Qian, Junbo Liang, Rong Huang, Wei Song, Jianming Ying, Xinyu Bi, Jianjun Zhao, Zhenyu Shi, Wenjie Liu, Jianmei Liu, Zhiyu Li, Jianguo Zhou, Zhen Huang, Yefan Zhang, Dongbing Zhao, Jianxiong Wu, Liming Wang, Xiao Chen, Rui Mao, Yanchi Zhou, Lei Guo, Hanjie Hu, Dazhuang Ge, Xingchen Li, Zhiwen Luo, Jinjie Yao, Tengyan Li, Qichen Chen, Bingzhi Wang, Zhewen Wei, Kun Chen, Chunfeng Qu, Jianqiang Cai, Yuchen Jiao, Li Bao, Hong Zhao
Journal: Gut (2024)

Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), mostly characterised by HBV integrations, is prevalent worldwide. Previous HBV studies mainly focused on a few hotspot integrations. However, the oncogenic role of the other HBV integrations remains unclear. This study aimed to elucidate HBV integration-induced tumourigenesis further.
Differentiating Brown Tumor From Bone Metastasis in Parathyroid Cancer Using 18F-FDG PET and 99mTc-MIBI SPECT
Authors: Suzune Tsukamoto, Kazuna Kawabata, Hitomi Kawamura, Kuniaki Takata, Makoto Hosono
Journal: Clinical Nuclear Medicine (2024)

Abstract A 69-year-old woman presented with a right clavicle pain. CT revealed a pathological fracture of the right clavicle, multiple osteolytic lesions, and a left cervical mass. 18 F-FDG PET/CT demonstrated a marked FDG uptake in the cervical mass and osteolytic lesions indicative of metastatic parathyroid cancer. 99m Tc-MIBI SPECT/CT revealed either faint or no uptake in the osteolytic lesions. However, a histopathological analysis after a parathyroidectomy and right clavicle biopsy confirmed the diagnosis of parathyroid cancer and the presence of benign brown tumors secondary to hyperparathyroidism. Postoperative imaging showed sclerotic change and a decreased FDG uptake in the bone lesions.