tbuckley/cabot-search huggingface dataset:
Unraveling the role of stromal disruption in aggressive breast cancer etiology and outcomes
Authors: Mustapha Abubakar, Máire A Duggan, Shaoqi Fan, Ruth M Pfeiffer, Scott Lawrence, Karun Mutreja, Alyssa Klein, Hela Koka, Thomas U Ahearn, Jill E Henry, Brian L Sprague, Pamela M Vacek, Donald L Weaver, Kathryn Richert-Boe, Teresa M Kimes, Nicolas Titiloye, Lawrence Edusei, Jonine D Figueroa, Xiaohong R Yang, Montserrat Garcia-Closas, Thomas E Rohan, Gretchen L Gierach
Journal: JNCI Journal of the National Cancer Institute (2025)

Abstract Background Aggressive (typically high-grade) breast cancers (BCs) remain major contributors to BC-related mortality globally. The tissue changes underpinning their etiology and outcomes, however, remain poorly characterized. Methods Spatially resolved machine-learning algorithms were used to characterize “stromal disruption” as a morphological metric of reduced/altered extracellular matrix and increased immune, inflammatory, and/or wound response-related processes in normal, benign breast disease (BBD), and invasive hematoxylin and eosin (H&amp;E)-stained breast tissues. Associations of stromal disruption with BC etiologic factors were assessed among 4023 healthy breast tissue donors, its impact on BC incidence was assessed among 974 BBD patients in a nested case–control study, while its prognostic associations were assessed in 4 BC patient cohorts (n = 4223). Results Epidemiologic risk factors for aggressive BC, including younger age, multiparity, Black race, obesity, and family history, demonstrated strong associations with increasing stromal disruption in H&amp;E sections prior to tumor development. Substantial stromal disruption in BBD H&amp;E was associated with ∼4-fold increased risk of aggressive (high-grade) BC and ∼3 years shorter latency from BBD to BC diagnosis, independently of BBD histology. Across BC cohorts, stromal disruption in H&amp;E was associated with aggressive (mostly high-grade) tumor phenotypes and with markedly poor prognosis among ER-positive patients, irrespective of histology. The immunobiology of stromal disruption reflected heightened innate (CD68+), adaptive (CD3+CD4+, CD3+CD8+), immunoregulatory (CD3+CD4+FOXP3+), immune escape (PD1+PDL1+), endothelial (CD31+), and myofibroblast (α-SMA+) marker expression. Conclusion Our findings highlight the active stromal role in aggressive BC etiology and outcomes, opening possibilities for readily identifying high-risk women across the BC continuum that may benefit from stroma-centric preventative or therapeutic strategies.
CMR Left Ventricular 4D-Flow: Differences in Flow Components and Kinetic Energy across Heart Failure Spectrum
Authors: Wong Hau Wai, Haonan Wang, Chi Ting Kwan, Eponine Wong, Celina Xu, Kwan Ho Leung, Jumatay Biekan, Jinyoung Jang, Kai-Hang Yiu, Hung-Fat Tse, Martin Janich, David Montero Barril, Andrew Yan, Vanessa Ferreira, Ming-Yen Ng
Journal:  (2025)

Abstract Aims Cardiovascular magnetic resonance (CMR) 4-dimensional (4D) intraventricular flow analysis quantifies volume and kinetic energy (KE) of direct flow, and residual volume components, illustrating heart failure (HF) hemodynamic changes. Study aims were (1) Compare volume and KE indexed (KEi) of direct flow and residual volume between groups. (2) Assess relationship between 4D-flow parameters with CMR parameters. Methods and Results 187 subjects (63.0 +/- 17.1yrs; 101 males) comprising 78 controls, 47 HF with preserved ejection fraction (HFpEF), 25 HF with mildly reduced ejection fraction (HFmrEF), 37 HF with reduced ejection fraction (HFrEF) were included. Volume and KEi of direct flow, and residual volume were obtained from 4D flow CMR images. Controls had highest direct flow volume and systolic KEi (control 35.0% &amp; 54.7 µJ/mL), followed by HFpEF (22.7% &amp; 61.4 µJ/mL), HFmrEF (13.1% &amp; 43.3 µJ/mL), HFrEF (5.2% &amp; 33.1 µJ/mL) (p&amp;lt;0.001). Residual volume and diastolic KEi were lowest in controls (26.0% &amp; 7.9 µJ/mL), and higher across HFpEF (31.8% &amp; 7.8 µJ/mL), HFmrEF (41.6% &amp; 10.8 µJ/mL), HFrEF (49.5% &amp; 11.5 µJ/mL) (p&amp;lt;0.001). Direct flow volume correlated positively with left ventricular ejection fraction (LVEF) (r= 0.794), but negatively with LV-end-diastolic volume indexed (EDVi) (r= -0.563) (all p&amp;lt;0.001). Residual volume correlated negatively with LVEF (r= -0.737) but positively with LV-EDVi(r= 0.602) (all p&amp;lt;0.001). Loss of two diastolic peaks in KE time curves for HF patients were shown. Conclusions CMR 4D direct flow and residual volume with their KEi showed hemodynamic changes and KEi time curve pattern distortions in HF.
A Salmonella subset exploits erythrophagocytosis to subvert SLC11A1-imposed iron deprivation
Authors: Béatrice Roche, Beatrice Claudi, Olivier Cunrath, Christopher K E Bleck, Minia Antelo-Varela, Jiagui Li, Dirk Bumann
Journal: Cell Host & Microbe (2025)

Solute carrier family 11 member 1 (SLC11A1) is critical for host resistance to diverse intracellular pathogens. During infection, SLC11A1 limits Salmonella's access to iron, zinc, and magnesium, but only magnesium deprivation significantly impairs Salmonella replication. To understand the unexpected minor impact of iron, we determined Salmonella's iron access in infected SLC11A1-deficient and normal mice. Using reporter strains and mass spectrometry of Salmonella purified from the spleen, we found that SLC11A1 caused growth-restricting iron deprivation in a subset of Salmonella. Volume electron microscopy revealed that another Salmonella subset circumvented iron restriction by targeting iron-rich endosomes in macrophages degrading red blood cells (erythrophagocytosis). These iron-replete bacteria dominated overall Salmonella growth, masking the effects of the other Salmonella subset's iron deprivation. Thus, SLC11A1 effectively sequesters iron, but heterogeneous Salmonella populations partially bypass this nutritional immunity by targeting iron-rich tissue microenvironments.
NanoCRISPR-Assisted Biomimetic Tissue-Equivalent Patch Regenerates the Intervertebral Disc by Inhibiting Endothelial-to-Mesenchymal Transition
Authors: Yong Huang, Hao Li, Lin Qi, Zhe Wang, Zheng Liu, Ruibang Wu, Qian Chen, Ce Zhu, Dan Sun, Limin Liu, Li Zhang, Ganjun Feng
Journal: Biomaterials (2025)
High dose, subcutaneous injections of benzathine penicillin G (SCIP) to prevent rheumatic fever: a single arm, phase IIa trial of safety and pharmacokinetics
Authors: Julie Bennett, Sam Salman, Dhevindri Moodley, Hazel Dobinson, Erik Andersen, Anneka Anderson, Brioni Moore, Madhu Page-Sharp, Kevin Batty, Jonathan Carapetis, Michael Baker, Joesph Kado, Laurens Manning
Journal: Journal of Infection (2025)

This Phase-IIa trial evaluates the safety and pharmacokinetics of high-dose, 10 weekly subcutaneous injections of penicillin (SCIP) in young people with a history of acute rheumatic fever (ARF). Participants received 7.2-10.8 MU (13.8-20.7mL) of Bicillin-LA® via subcutaneous injection in Wellington, New Zealand. A subset underwent intensive safety monitoring and serial dried blood spot collection for penicillin assay. Penicillin concentrations informed a population pharmacokinetic model based on 169 data points from 31 participants. The proportion of time penicillin concentrations remained above a range of plausible pharmacological correlates of protection was estimated for SCIP and compared with estimates for intramuscular benzathine penicillin G (BPG). Fifty-five participants received SCIP at least once, totalling 182 doses. No recurrent ARF or breakthrough streptococcal throat infections were reported. Model-based simulations indicated that SCIP outperformed intramuscular BPG in maintaining protective concentrations across nearly all plausible pharmacological target correlates of protection (10-20ng/mL). SCIP performed even more favourably when considering modified weight-based dosing or missed BPG injections. SCIP is safe and well tolerated, demonstrating favourable penicillin exposure for most individuals. Future research should explore the effectiveness of SCIP over longer periods and in diverse populations and settings.
Synergistic effects of LCN2 and TWEAK on the progression of psoriasis
Authors: Kaixuan Ren, Xueting Peng, Xudong Duan, Rongfang Feng, Christopher Cook, Mei Lu, Min Li, Hanjiang Gu, Xiaoyu Wang, Guorong Deng, Huiqun Ma, Yale Liu, Yumin Xia
Journal: Cellular and Molecular Immunology (2025)

Abstract Lipocalin 2 (LCN2) and the TWEAK/Fn14 signaling pathways are pivotal in psoriasis, influencing epidermal development, inflammatory cell chemotaxis, and inflammatory factor release. Despite their significant roles, the intricate relationship between LCN2 and TWEAK/Fn14 pathways remains unclear. Our study revealed the correlation between the expression of TWEAK, LCN2, and Fn14 in psoriatic lesions. We found that TWEAK is expressed by keratinocytes and macrophages, while LCN2 is expressed by keratinocytes and neutrophils. Surface plasmon resonance experiments demonstrated binding between LCN2 and Fn14, which was further validated by co-immunoprecipitation and cellular co-localization via immunofluorescence. In vitro, LCN2 promoted macrophage differentiation and TWEAK secretion, enhanced TWEAK and Fn14 expression in keratinocytes, and activated the MAPK signaling pathway. TWEAK upregulated LCN2 expression in neutrophils but not in keratinocytes. Bulk RNA-seq analysis revealed a synergistic effect of LCN2 and TWEAK in promoting inflammatory cytokine expression in keratinocytes, with enhanced MAPK pathway activation in the presence of M5 cytokines. Lcn2 knockout reduced Fn14 expression in skin lesions and serum TWEAK levels of imiquimod-induced murine psoriasis model, while Fn14 knockout attenuated the epidermal hyperplasia-promoting effects of TWEAK and LCN2. Overexpression of Fn14 in keratinocytes led to higher TWEAK expression upon LCN2 stimulation, suggesting a self-reinforcing loop among TWEAK, LCN2, and Fn14. We propose that LCN2 synergizes with TWEAK through Fn14 to drive psoriasis pathogenesis.
Same-session endoscopic ultrasound-guided gallbladder drainage for acute cholecystitis with lumen-apposing metal stent and rendezvous for biliary stones in invisible papilla
Authors: Davide Scalvini, Aurelio Mauro, Stefano Mazza, Carlo Ciccioli, Marco Bardone, Francesca Torello Viera, Andrea Anderloni
Journal: Endoscopy (2025)
Endoscopic ultrasound-guided hepaticogastrostomy with antegrade stenting using a catheter-like delivery system: a novel technique completely omitting the fistula dilation step
Authors: Tadahisa Inoue, Rena Kitano, Tomoya Kitada, Shun Futagami, Masato Yano, Jun Arai, Kiyoaki Ito
Journal: Endoscopy (2025)
Risk-Based Lung Cancer Screening in Clinical Practice
Authors: Matthew M Rode, Anne-Marie G Sykes, Mark S Allen, Lori A Ingalls, Hamid Rehman, Daniel C Deetz, Susanne C Degen, Janel N Glantz, Adel Zurob, Jamil Taji, Karen L Swanson, Eric A Jensen, Laura C Pappagallo, Margaret M Johnson, Barbara L McComb, Lynn M Loosbrock, Andrew C Hanson, Ping Yang, David E Midthun
Journal: Journal of Thoracic Oncology (2025)
DIAGNOSIS AND MANAGEMENT OF UPPER GASTROINTESTINAL INVOLVEMENT IN ADULT PATIENTS WITH CROHN’S DISEASE: A SYSTEMATIC REVIEW
Authors: Nathaniel A Cohen, Neta Sror, Maliha Naseer, Dominik Bettenworth, Cathy Lu, Raneem Khedraki, Maria Abreu, Raja Atreya, Badr Al-Bawardy, Susan J Connor, Geert d'Haens, Iris Dotan, Axel Dignass, Sara El Ouali, Brian Feagan, Roger Feakins, Richard Gearry, Ilyssa O Gordon, Charlotte Hedin, Taku Kobayashi, Haim Leibovitzh, Nitsan Maharshak, Jacob Ollech, Shaji Sebastian, Britta Siegmund, David T Rubin, Mark S Silverberg, Flavio Steinwurz, Joana Torres, Gill Watermeyer, Cristian Hernandez-Rocha, Paige Gurizzian, Alexa Silfen, Roie Tzadok, Katherine Falloon, Florian Rieder
Journal: Clinical Gastroenterology and Hepatology (2025)
Efficacy and Safety of Ruxolitinib Cream in Children Aged 2 to 11 Years With Atopic Dermatitis: Results From TRuE-AD3, a Phase 3, Randomized Double-Blind Study
Authors: Lawrence F Eichenfield, Linda F Stein Gold, Eric L Simpson, Andrea L Zaenglein, April W Armstrong, Megha M Tollefson, Weily Soong, Lara Wine Lee, Alim R Devani, Seth B Forman, Dareen D Siri, Howard Kallender, Brett Angel, Qian Li, Xuejun Chen, Amy S Paller
Journal: Journal of the American Academy of Dermatology (2025)
Advancements in Diversity in Dermatology: A 5-Year Retrospective Analysis of Racial and Ethnic Trends in U.S. Dermatology Residency Programs (2020-2024)
Authors: Devin Barzallo, Afua Ofori-Darko, Larissa De Souza, Precious Nwanwa, Timmie Sharma
Journal: Journal of the American Academy of Dermatology (2025)
A pilot randomized control trial to assess the adjunctive effect of diet on response to advanced therapies in patients with UC
Authors: O M Damas, M Leo, N Colina, M Mijares, I Fernandez, J McALeavy, I Hernandez, C Assumpcao, L Garces, M A Quintero, M Ortega, N Solis, C Batista, B De La Torre, M T Abreu, A R Deshpande, D Kerman, Proksell S, Y Ban
Journal: Clinical Gastroenterology and Hepatology (2025)
Risk of Giant Cell Arteritis Among Patients Presenting With Undifferentiated Non-Infectious Uveitis
Authors: Muhammad Z Chauhan, Jawad Muayad, J Anthony Chacko, Asad Loya, Zain S Hussain, Chaow Charoenkijkajorn, Paul H Phillips, Joseph G Chacko, Ahmed B Sallam
Journal: Ophthalmology (2025)
Editor's note to ‘harnessing the potential of human breast milk to boost intestinal permeability for nanoparticles and macromolecules’ [journal of controlled release, 379 (2025) 768–785]
Authors: Si Naftaly, Topaz Pery, Rawan Mhajne, Areen Ashkar, Maya Davidovich-Pinhas, Assaf Zinger, Stefaan De Smedt
Journal: Journal of Controlled Release (2025)
Methodological opportunities in genomic data analysis to advance health equity
Authors: Brieuc Lehmann, Leandra Bräuninger, Yoonsu Cho, Fabian Falck, Smera Jayadeva, Michael Katell, Thuy Nguyen, Antonella Perini, Sam Tallman, Maxine Mackintosh, Matt Silver, Karoline Kuchenbäcker, David Leslie, Nilanjan Chatterjee, Chris Holmes
Journal: Nature Reviews Genetics (2025)
Convergent evidence linking neonatal vitamin D status and risk of neurodevelopmental disorders: a Danish case-cohort study
Authors: Henriette Thisted Horsdal, Clara Albiñana, Zhihong Zhu, Sanne Grundvad Boelt, Nis Borbye-Lorenzen, Arieh S Cohen, Kristin Skogstrand, Lars Melgaard, Nadia Jensen MacSween, Marta Jadwiga Thorbek, Oleguer Plana-Ripoll, Liselotte Vogdrup Petersen, Cynthia M Bulik, Anders D B Rglum, Ole Mors, Merete Nordentoft, Thomas Werge, Gunn-Helen Moen, Shannon D'Urso, Naomi R Wray, Bjarni J Vilhjálmsson, Esben Agerbo, Carsten B Cker Pedersen, Preben Bo Mortensen, John J McGrath
Journal: The Lancet Psychiatry (2025)
Etrasimod as a treatment for eosinophilic oesophagitis (VOYAGE): a double-blind, placebo-controlled, randomised, phase 2 trial
Authors: Evan S Dellon, Margaret H Collins, Albert J Bredenoord, Hamish Philpott, Luc Biedermann, Márjori Dulcine, Thai Nguyen-Cleary, Chinyu Su, Jin Yu, Huaming Tan, Fabio Cataldi, Joseph Wu, Wenjin Wang, Pamela Clax, John C Woolcott, Ikuo Hirano
Journal: The Lancet. Gastroenterology & hepatology (2025)
Carbon markets: a new form of colonialism for Indigenous Peoples?
Authors: Nicole Redvers, Josh Chan, Siwakorn Odochao, Victoria Pratt, Jessica Sim, Samrawit Gougsa, Daniel M Kobei, Liz Willetts
Journal: The Lancet Planetary Health (2025)

The interconnected and compounding climate change and biodiversity crises have led to increased urgency in moving towards transformational change within how national and international sustainability efforts are viewed and operationalised. Despite the known benefit of carbon markets as part of these sustainability efforts, there has been increasing scrutiny of carbon market mechanisms, with warranted distrust present at the community level. Indigenous Peoples are key stewards of biodiverse landscapes, yet their exclusion within carbon market decision making is ongoing. With this exclusion, outstanding questions remain on the placement of Indigenous Peoples within current carbon market design and decision making and their roles have yet to be fully appreciated in wider policy and practice. Platformed on substantial inequities, marginalisation, and racism, we therefore query in this Personal View, are carbon markets a new form of colonialism? We further reflect on the challenges and the potential opportunities of carbon markets for Indigenous Peoples and anchor our reflections with examples from different regions.
Power to the people: towards greater social participation in planetary health
Authors: Laura E Downey, Haryani Saptaningas, Maroof Khan, Maarinke van der Meulen, Claudia Batz, Mere Naulumatua, Maria Nillsson, Linh Thùy Nguyên, Nanoot Mathurapote, Tanja Kuchenmueller, Amanda Shriwise, Göran Tomson
Journal: The Lancet Planetary Health (2025)
Pharmacological treatment of anxiety in older adults: a systematic review and meta-analysis
Authors: Sarah E Neil-Sztramko, AnneMarie Levy, Alastair J Flint, Zahra Goodarzi, Amy Gough, Shanna C Trenaman, Michael Van Ameringen, Erica Weir, Anthony Yeung, Mahnoor R Akram, Titus A Chan, Sébastien Grenier, Heli Juola, Juliette Mojgani, Kristin Reynolds, Carly Whitmore, Andrea Iaboni
Journal: The Lancet Psychiatry (2025)
Behavioral and Economic Interventions: A Path to Improved Dietary Behaviors
Authors: Hanin Hosni, Marco A. Palma, Michelle S. Segovia
Journal: Annual Review of Nutrition (2025)

This narrative review provides a summary and critical discussion of the effectiveness of behavioral and economic interventions in promoting healthier eating habits. While financial incentives alter food choices through changes in prices and monetary incentives, behavioral nudges leverage human biases to subtly push individual choice toward welfare-enhancing options without restricting freedom of choice or using monetary instruments. Review articles and empirical studies were selected on the basis of predefined criteria, focusing on the impact of interventions on food purchase, consumption, and adiposity indicators. Our findings highlight the strengths and limitations of both approaches and reveal potential synergies and gains from financial and behavioral interventions. This narrative review identifies research gaps and provides recommendations for future investigations to enhance the effectiveness and scalability of interventions aimed at improving dietary behaviors.
The effect of air pollution exposure on menstrual cycle health using self-reported data from a mobile health app: a prospective, observational study
Authors: Priyanka N deSouza, Amanda A Shea, Virginia J Vitzthum, Fabio Duarte, Claire Gorman Hanly, Meghan Timmons, Patricia Huguelet, Mary D Sammel, Carlo Ratti, Danielle Braun, Rachel C Nethery
Journal: The Lancet Planetary Health (2025)

Toxicological evidence suggests that ambient air pollution has endocrine-disrupting properties that can affect menstrual cycle functioning, which represents an important marker of women's reproductive health. We aimed to estimate the effect of short-term and long-term PM2·5 exposure on menstrual cycle outcomes across the USA, Brazil, and Mexico using self-reported data from a mobile health app. For this prospective observational study, we collected de-identified self-reported data from the Clue mobile health app, in which users self-tracked menstruation cycles. For the current study, eligible participants were aged 18-44 years, were not using hormonal birth control, and lived in one of 230 cities in the USA, Mexico, or Brazil. The primary outcome of interest at the city level was the proportion of menstrual cycles with abnormally short length (<24 days) and long length (>38 days) of all cycles recorded. The primary outcome at the cycle level was a binary indicator: abnormal cycle length (<24 days or >38 days) or not (normal cycle length). We used regression analyses to evaluate associations between long-term PM2·5 concentrations (mean concentration between 2016 and 2020) and the city-level outcomes after controlling for potential confounders. Conditional logistic regression models were used to evaluate associations between cycle-specific PM2·5 and if a cycle was of abnormal length within an individual in the dataset, after controlling for time-varying factors. Between Jan 1, 2016 and Dec 31, 2020, 92 550 app users residing in 230 cities across the USA, Brazil, and Mexico provided data corresponding to 2 220 281 menstrual cycles, and were included in our main cohort. A significant association was observed between long-term PM2·5 exposure and the proportion of menstrual cycles of abnormally long or short duration (odds ratio [OR] 1·023 [95% CI 1·013-1·033]) and the proportion of cycles that were specifically abnormally long (OR 1·036 [1·023-1·049]) for every 10 μg/m3 increase in PM2·5. No associations were identified between short-term PM2·5 concentrations and abnormal cycle length. These findings suggest that PM2·5 exposure affects menstrual cycle outcomes. More research is needed to better elucidate the biological mechanisms through which PM2·5 affects the menstrual cycle. None.
Predicting the risk of subsequent progression in patients with systemic sclerosis-associated interstitial lung disease with progression: a multicentre observational cohort study
Authors: Anna-Maria Hoffmann-Vold, Liubov Petelytska, Håvard Fretheim, Trond Mogens Aaløkken, Mike Oliver Becker, Hilde Jenssen Bjørkekjær, Cathrine Brunborg, Cosimo Bruni, Christian Clarenbach, Phuong Phuong Diep, Rucsandra Dobrota, Michael T Durheim, Muriel Elhai, Thomas Frauenfelder, Suiyuan Huang, Suzana Jordan, Emily Langballe, Øyvind Midtvedt, Carina Mihai, Erica Mulcaire-Jones, Janelle Vu Pugashetti, Marco Sprecher, Justin Oldham, Øyvind Molberg, Dinesh Khanna, Oliver Distler
Journal: The Lancet Rheumatology (2025)
Insulin for early glycaemic abnormality in children with cystic fibrosis without cystic fibrosis-related diabetes (CF-IDEA): a randomised controlled trial
Authors: Shihab Hameed, Elizabeth H Barnes, Julie Briody, Claire E Wainwright, Jodi Hilton, Penny I Field, Andrew Tai, Yvonne Belessis, Christine L Chan, Hiran Selvadurai, Bernadette Prentice, Tamarah Katz, Sarah K McMahon, Michelle Neylan, Alexia Pena, Adam Jaffe, Charles F Verge
Journal: The Lancet Child & Adolescent Health (2025)
Predicting paediatric pneumonia severity in the emergency department: a multinational prospective cohort study of the Pediatric Emergency Research Network
Authors: Todd A Florin, Daniel J Tancredi, Lilliam Ambroggio, Franz E Babl, Stuart R Dalziel, Michelle Eckerle, Santiago Mintegi, Mark I Neuman, Amy C Plint, Norma-Jean Simon, Nathan Kuppermann
Journal: The Lancet Child & Adolescent Health (2025)