tbuckley/cabot-search huggingface dataset:
Abstract 18315: A Thrombus-specific Drug Delivery System Using Biological Polymer Micelle Complex for the Treatment of Actively Forming Vascular Thromboembolism
Authors: Joo Heung Yoon, Changsun Kang, On Hwang, Byung Ryul Cho, Dongwon Lee, Peter M Kang
Journal: Circulation (2014)

Treatments for vascular thrombosis such as systemic anticoagulants are often limited by continuous infusion and bleeding complications. We sought to develop a novel drug-delivery system that is targeted and more effective in inhibiting thrombus formation. Biological micelle was selected for its small size, a modifiable surface structure to attach target-specific molecule, and a drug-loading capacity. Micelle was consisted of hydrophilic-hydrophobic interactions of mPEG-PCL (methoxy poly(ethylene glycol)-poly(caprolactone)) and pluronic F-127. A pentapeptide CREKA (H-Cys-Arg-Glu-Lys-Ala-OH), which has been shown to have a high affinity to fibrinogen-fibrin complex, was covalently bounded to micelle for target specific attachment to actively forming thrombus. Tirofiban, a glycoprotein IIb-IIIa inhibitor, was selected for this study because of its high potency but high risk of bleeding. First, the half-life of micelle complex was about 15 hours. Then, we evaluated these micelles for in vivo bleeding time using tail vein puncture. We found that micelle complex loaded with tirofiban with CREKA showed 40% increase in the bleeding time compared to the micelle without CREKA suggesting effective site-specific attachment and inhibition of thrombus formation. For therapeutic efficacy of drug-loaded micelle complex, inferior vena cava (IVC) was banded to make an 80-90% stenosis, which resulted in subacute thrombus formation within 48 hours. Animals with IVC stenosis were treated with micelle containing 10% of weight-adjusted therapeutic dose of tirofiban. The micelle treated group showed superior thrombus-suppressing effect with 65% reduction in thrombus weight to those treated with 10% of tirofiban without micelle complex in i.p. administration every 8 hours, and 49% reduction compared to continuous administration of tirofiban using osmotic pump. Thus, our micelle complex showed thrombus-specific binding capacity, and demonstrated significantly lower need for therapeutic dose of tirofiban to achieve similar thrombus-suppressing effects as full tirofiban dosage. Thus, this novel drug-delivery system using micelle complex could be used to treat thromboembolism diseases with greater potency and with less bleeding risk.
The Treatment of Rheumatism
Authors: Harlow Brooks
Journal: Annals of Internal Medicine (1928)

Article1 July 1928The Treatment of RheumatismHARLOW BROOKSHARLOW BROOKSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-1-83 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAny paper on the subject of "Rheumatism" at this time might almost be properly begun with an apology, for the reason that all clinicians of today are much confused in their own minds as to just what is meant by rheumatism. To many, rheumatism still means any sort of arthritis or almost any disease condition which is largely characterized by a nontraumatic joint inflammation. Others of us demand as a requisite that the term "rheumatism" be limited to a disease process in which an arthritis appears as an evidence of a generalized infection. This would then also include those not... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York City*Read in abstract before the Association of American Physicians, May 3rd, 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1928Volume 2, Issue 1Page: 83-96KeywordsArthritisInfectious diseasesInflammation Issue Published: 1 July 1928 PDF downloadLoading ...
Abstract 2069: Aortic Valve Replacement In Patients With Bicuspid Aortic Valve Disease Is Not Followed By Progressive Aortic Dilatation: A 15-year Study
Authors: Ayyaz Ali, Amit Patel, Darren Freed, Yasir Abu-Omar, Ahmad Y Sheikh, Ziad Ali, Anthony Rostron, Thanos Athanasiou, John Pepper
Journal: Circulation (2007)

Objectives A bicuspid aortic valve may be associated with an aortopathy, this may lead to progressive aortic dilatation over time. It is uncertain whether the ascending aorta should be replaced prophylactically during AVR in these patients. We analyzed change in ascending aortic diameter following AVR, to determine whether a clinically important aortic pathology exists in patients with bicuspid aortic valve disease. Methods Demographic, operative and clinical data were obtained retrospectively through casenote review. AVR was performed using a homograft or porcine stentless valve using the subcoronary implantation technique. Patients were grouped according to whether their native aortic valve was identified as tricuspid (TC) or bicuspid (BC) at operation. Serial transthoracic echocardiograms were analyzed to measure pre-operative and post-operative ascending aortic diameter. Results 217 patients underwent AVR between 1 st January 1991 and 1 st January 2001. Ninety patients had a bicuspid aortic valve, in the remaining 127 the valve was tricuspid. The bicuspid group was younger ( BC 62yr +/− 15, TC 71yr +/− 12 yrs; p &lt; 0.001). Follow-up echocardiography was performed 6.0 +/− 4.3 years post-operatively. Pre-operative ascending aortic diameter was similar (BC 3.2 +/− 0.5, TC 3.2 +/− 0.5 cm; p = 0.56) There was no difference in the increase in ascending aortic diameter over follow-up (BC 0.1 +/− 0.5, TC 0.0 +/− 0.5 cm; p = 0.34) Conclusion The clinical importance of “bicuspid aortopathy” in an older age group appears to be minimal. Additional aortic procedures designed to protect against progressive aortic aneurysmal disease in this setting are not justified.
Abstract 266: Ethnic Differences in Patient Characteristics but Not Implantable Cardioverter-Defibrillator (ICD) Utilization Rates for Primary Prevention of Sudden Cardiac Death (SCD)
Authors: Narendra Singh, Preetinder Kaleka, David Song, Sandeep Chandra, David Suh, Linda Yan, Anthony Dorsey, Suresh Ramamurthy
Journal: Circulation (2011)

Background: Underutilization of ICD's for primary prevention of SCD has been previously reported. Whether ethnic differences in utilization play a role in this is unclear. Method: Retrospective chart review of consecutive heart failure (HF) pts in a suburban outpatient cardiology practice from Jan 2006-Dec 2010. Results: Of the 2813 HF pts, 533 (19/%) had an ejection fraction of &lt;35%, of whom 170 (32%) received an ICD device. Of the 533 pts, 23% were Caucasian (C), 67% African American (AA), 6% Southeast Asian (SEA), 3% East Indian (EI), 2% Hispanic (H). The mean age was 63+18 yrs, with AA (60 yrs) being youngest and C (72 yrs) the oldest (p&lt;0.001). Mean EF (23%) ranged from 21% in EI to 25% in C (p&lt;0.04). EI pts had more CAD (71%, p=&lt;0.01) while AA pts had more hypertension (91%, p&lt;0.001). No sig differences in smoking (16%) diabetes (39%), PVD (24%) hyperlipidemia (62%) or family history (37%) was seen. In those pts without an ICD (n=363) no documentation of a discussion was noted in 55% of charts. Documented pt refusal of an ICD trended higher in EI pts (29% p&gt;0.057) Although males made up 62% of the group and were younger (62 vs 65 yrs,p&lt;0.05) no gender differences in ICD implantation rates were seen. Pts were well treated for HF with no ethnic differences noted for use of diuretics (81%), ACEI/ARB (79%), beta-blockers (89%), digoxin (28%) warfarin 22% and aspirin (59%) Only statins were used more commonly in EI vs AA (71% vs 50%, p&lt;0.05) Conclusions: Our findings suggest that ICD's for primary prevention of SCD are underutilized in multiple ethnic groups. Lack of a documented discussion re ICD's is too common. There are significant ethnic differences in pt characteristics for HF etiology but not for HF pharmacotherapy utilization. Patient refusal rates for ICD's also vary among ethnic groups and require further evaluation to see if these differences can explain the observed underutilization of device therapy.
Long-Term Efficacy of α-Interferon in β-Thalassemics With Chronic Hepatitis C
Authors: V. Di Marco, O. Lo Iacono, P. Almasio, C. Ciaccio, M. Capra, M. Rizzo, R. Malizia, A. Maggio, C. Fabiano, F. Barbaria, A. Craxı̀
Journal: Blood (1997)
Incidence and Outcomes of Acute Lung Injury
Authors: Gokhan M Mutlu, G R Scott Budinger
Journal: New England Journal of Medicine (2006)

to the editor: Rubenfeld and colleagues (Oct. 20 issue)1 discuss the incidence and outcomes of acute lung injury in a large, population-based cohort study. The authors provide data on the known risk factors of acute lung injury and convincingly suggest that their population cohort was representative of the U.S. population as a whole. We are surprised, however, that they did not include data that address characteristics that might protect patients against the development of acute lung injury. As previously reported by Moss and colleagues, the incidence of and mortality from acute respiratory distress syndrome are reduced in patients with diabetes mellitus.2 Experimental data published more recently3 support these data on humans. Although the mechanisms by which diabetes provides “protection” against acute lung injury are not well understood, leptin resistance may play an important role. In future studies, inclusion of data about patient characteristics that either improve or worsen the outcomes of acute lung injury might facilitate the development of novel strategies to improve the care of patients with this deadly disease. Gokhan M. Mutlu, M.D. G.R. Scott Budinger, M.D.
应用(牙合)垫治疗颞下颌关节功能紊乱综合征90例
Authors: 尹杨
Journal: BMJ (2008)

颞下颌关节功能紊乱综合征（temoromandibulal disorders，TMD）是口腔科的常见病及多发病。多用保守方法治疗。我科自2000年2月至今，应用[牙合]垫治疗[牙合]因素引起的颞下颌关节功能紊乱综合征90例，获得良好效果。
Carbamazepine in the treatment of bulimia
Authors: A S Kaplan, P E Garfinkel, P L Darby, D M Garner
Journal: American Journal of Psychiatry (1983)

Of six bulimic outpatients who completed a double-blind crossover trial with carbamazepine, one patient, who had a history suggestive of bipolar disorder, responded dramatically with cessation of binge eating. This supports a possible link in some patients between bulimia and affective illness.
Abstract 13855: Is Myocardial Fibrosis Limited to the LV in HCM? A CMR Focus on the RV
Authors: Nessim Amin, Saundra Grant, Mark Doyle, Ronald Williams, June Yamrozik, Diane Thompson, Moneal Shah, Robert W Biederman
Journal: Circulation (2013)

Introduction: CMR has become the leading modality to define the clinical impact of hypertrophic cardiomyopathy (HCM) providing complete coverage of both ventricles with high spatial resolution. Lat...
Decitabine Is More Cost Effective Than Standard Conventional Induction Therapy In Elderly Acute Myeloid Leukemia Patients
Authors: Nicolas Batty, Samuel Wiles, Mathew Kabalan, Rohit Sharma, Joseph Shatzel, Jonathan Pang, David Yi, Iris Alatovic, Sana Saif, Deepika Narasimha, Joseph LaPenna, Anthony Troitino, Kristopher Attwood, Yong Yin, Meir Wetzler
Journal: Blood (2013)
Abstract 20073: Prevention of Contrast-Induced Acute Kidney Injury: A Mixed Methods Analysis Running Title: Acute Kidney Injury Prevention
Authors: Jeremiah R Brown, Peter A McCullough, Louise Davies, Mark E Splaine, Cathy S Ross, Harold L Dauerman, John F Robb, Richard A Boss, David J Goldberg, Frank A Fedele, Mirle A Kellett, William J Phillips, Peter M Ver Lee, Michael R Jacuch, Eugene C Nelson, Gerald T O'Connor, Mark J Sarnak, David J Malenka
Journal: Circulation (2010)
Update: Influenza Activity — United States, September 30, 2018–February 2, 2019
Authors: Lenee Blanton, Vivien G. Dugan, Anwar Isa Abd Elal, Noreen Alabi, John Barnes, Lynnette Brammer, Alicia P. Budd, Erin Burns, Charisse N. Cummings, Shikha Garg, Rebecca Garten, Larisa Gubareva, Krista Kniss, Natalie Kramer, Alissa O’Halloran, Carrie Reed, Melissa Rolfes, Wendy Sessions, Calli Taylor, Xiyan Xu, Alicia M. Fry, David E. Wentworth, Jacqueline Katz, Daniel Jernigan
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

CDC collects, compiles, and analyzes data on influenza activity and viruses in the United States. During September 30, 2018-February 2, 2019,* influenza activity
Abstract 12624: Turbulence Induced T-wave Alternans at Elevated Heart Rates Predicts Risk of Arrhythmias in Post Acute Myocardial Infarction Patients
Authors: Raja N Ghanem, James W Johnson, Raphael Schneider, Poul Erik Bloch Thomsen, Heikki Huikuri
Journal: Circulation (2010)

Background:  Stratification of patients at risk of sudden cardiac death after acute myocardial infarction (AMI) remains a significant unmet clinical need. We hypothesized that turbulence induced T-wave alternans (TI-TWA) after premature ventricular contractions (PVC) at elevated heart rates is associated with vulnerability to life-threatening arrhythmias in post-AMI patients.   Methods:  A total of 5869 consecutive patients were screened in 10 European centers, and 312 patients (age 65 ± 11 years) with a mean LVEF of 31 ± 6% were included in the CARISMA study. A total of 191 patients provided analyzable 24hr holters acquired 5–21 days following the index MI. PVC with compensatory pauses were selected for analysis. TI-TWA was measured on modified V3 lead from the 16 beats following the PVC using the modified moving average method. The associations between TI-TWA at maximum heart rate (maxHR) and the study endpoints were analyzed using Cox and logistic regression methods. The primary endpoint (PE) was ECG-documented ventricular fibrillation or symptomatic sustained ventricular tachycardia (>30 sec) adjudicated as ‘most probably treatable by an ICD’ according to the consensus of the 5-member committee blinded to outcome. Secondary endpoints included all-cause mortality (ACM) and cardiac death (CD).   Results:  During a median follow up of 24.2 months and among the 191 patients studied, there were 15 PE, 20 ACM and 14 CD. A median of 12 (inter-quartile range 3–59) PVCs were analyzed per patient. On a continuous analysis, TI-TWA at maxHR (81 ±14 bpm) was associated with the PE (Area under the ROC 0.71 ± 0.06, p = 0.001). After adjusting for covariates (age, prior MI, history of congestive heart failure, and diabetes), dichotomized TI-TWA at maxHR using a cut-point of 95μV was a strong predictor of PE (HR=13.8 [1.8–105.2], p=0.012) but not ACM (HR=1.29 [0.52–3.21], p=0.586) or CD (HR=2.18 [0.68–7.05], p=0.191). Dichotomized TI-TWA at maxHR identified 93% of patients who developed the PE with positive predictive and negative predictive values of 15% and 99% respectively.   Conclusion:  TI-TWA at elevated heart rates measured early post-AMI in patients with LVEF≤0.40 is a strong novel risk marker for ventricular tachyarrhythmia and may guide ICD therapy.
Biomarkers of systemic inflammation after two resistance training protocols in moderate clinically stable COPD
Authors: Luciana C. Fosco, Dionei Ramos, Flavia A. Guarnier, Carlos M. Pastre, Alessandra Choqueta de Toledo, Giovana N.B. Ferrari, Rafaela Bonfim, Alcirene P. Souza, Rubens Cecchini, Ercy M.C. Ramos
Journal: European Respiratory Journal (2011)

Systemic inflammation is an important factor in skeletal muscle dysfunction (SMD) in chronic obstructive pulmonary disease (COPD) patients. The SMD can be reversed partially by physical training; however, the response is dependent of type, intensity and duration of exercise. This study evaluated the inflammatory response, muscle strength and fat-free mass outcomes in COPD patients comparing two protocols of resistance training. COPD (n=34) were assigned to conventional resistance training (CRT) or elastic tubing training (ETT) groups (n=17 each, FEV1= 1,23±0,46% and 1,24±0,54% predicted; aged 64,94±7,62 and 65,11±9 years, respectively). CRT group were trained at moderate intensity (3×10 RM) and ETT group were trained at 2-7 sets of repetitions determined individually by resistance to fatigue test. TNF-α, citokines 1L-1β and IL-10 on plasma by ELISA, peripheral muscle strength and fat-free mass were obtained at baseline (D0) and after the 8-weeks training intervention (D2). Citokines also were measured acutely immediately after the first (D1) and the last training session (D3). TNF-α, IL-1β and IL-10 increased in CRT group after 8 weeks compared to baseline (p<0.001, p<0.05 and p<0.001, respectively). IL-1β and IL-10 levels also increased in response to acute exercise (D1) and IL-10 measured acutely after 8 weeks training (D4) was reduced (p<0.01, compared to D3). No changes in cytokines levels in plasma were observed in the ETT group. Muscle strength increased in both groups, but only the ETT protocol increased the fat-free mass after 8 weeks. These findings suggest that structural and functional gains were obtained from a lower systemic cost in the ETT group.
First-line erlotinib in advanced non-small cell lung cancer (NSCLC) carrying an activating EGFR mutation: A multicentre academic phase II study in caucasian patients (pts) (NCT00339586)
Authors: Jacques De Greve, Jan Van Meerbeeck, Johan Vansteenkiste, Erik Teugels, C. Geers, Anne-Pascale Meert, P. Vuylsteke, Christian Focan, Jean-Luc Canon, Yves Humblet, Guy Berchem, Benoît Colinet, D Galdermans, Lionel Bosquée
Journal: Journal of Clinical Oncology (2011)
Small RNA profiling reveals deregulated phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/Akt pathway in bronchial smooth muscle cells from asthmatic patients
Authors: Elena Alexandrova, Nicola Miglino, Adnan Hashim, Giovanni Nassa, Claudia Stellato, Michael Tamm, Florent Baty, Martin Brutsche, Alessandro Weisz, Pieter Borger
Journal: Journal of Allergy and Clinical Immunology (2015)
Abstract 3299: Efficacy and Safety of Enoxaparin vs. UFH in Patients with ST-Elevation Myocardial Infarction Also Treated Or Not Treated with Clopidogrel: Analysis from ExTRACT-TIMI 25
Authors: Marc S Sabatine, David A Morrow, Satishkumar Mohanavelu, Sabina A Murphy, Carolyn H McCabe, Elliott M Antman, Eugene Braunwald
Journal: Circulation (2006)
Treatment of Barrett’s esophagus with a novel focal cryoablation device: a safety and feasibility study
Authors: Dirk Schölvinck, Hannah Künzli, Christine Kestens, Peter Siersema, Frank Vleggaar, Marcia Canto, Hilary Cosby, Julian Abrams, Charles Lightdale, Elizabeth Tejeda-Ramirez, Steven DeMeester, Christine Greene, Blair Jobe, Jeff Peters, Jacques Bergman, Bas Weusten
Journal: Endoscopy (2015)

<b>Background and aims: </b>Currently, eradication of Barrett's epithelium is preferably achieved using radiofrequency ablation (RFA) or spray cryoablation (SCA). However, both modalities suffer from drawbacks such as the need for sizing, multiple deployment steps, large controller units (RFA), imprecise dosing and need for gas-venting (SCA). The new Cryoballoon Focal Ablation System (CbFAS) may address these limitations. This study assessed the safety, feasibility, and dose response of the CbFAS in patients with flat Barrett's epithelium with or without dysplasia. <b>Patients and methods: </b>In this multicenter, prospective non-randomized trial, 39 patients were each treated with one or two ablations of 6, 8, or 10 seconds. Symptoms were assessed immediately and 2 days post-cryoablation. Follow-up endoscopy was performed 6 – 8 weeks post-procedure to assess response. Outcome parameters were incidence of adverse events, pain, esophageal stricture formation, and ablation response by cryogen dose. <b>Results:</b> Of 62 ablations, 56 (10 with 6 seconds, 28 with 8 seconds, 18 with 10 seconds) were successfully performed. Six ablations failed because of device malfunction (n = 3) and procedural or anatomic issues (n = 3). Median procedure time was 7 minutes (interquartile range [IQR] 4 – 10). No major adverse events occurred; six patients experienced a minor mucosal laceration requiring no intervention. Mild pain was reported by 27 % of patients immediately after cryoablation and by 14 % after 2 days. No strictures were evident at follow-up. Full squamous regeneration was seen in 47 treated areas (6 [60 %] of the 6-second areas; 23 [82 %] of the 8-second areas; 18 [100 %] of 10-second areas). <b>Conclusions:</b> Focal cryoablation of Barrett's epithelium with the CbFAS is feasible and safe, resulting in squamous regeneration in the majority of patients.
Salvaging brain ischemia by increasing neuroprotectant uptake via nanoagonist mediated blood brain barrier permeability enhancement
Authors: Shuyan Zheng, Ying-Ying Bai, Yikang Liu, Xihui Gao, Yan Li, Yinzhi Changyi, Yuancheng Wang, Di Chang, Shenghong Ju, Cong Li
Journal: Biomaterials (2015)
Molecular evidence of a GVL effect in allogeneic transplant for acute lymphoblastic leukemia restricted to Ph-negative leukemia: Post-transplant immuno-modulation performed according to molecular follow-up seems efficient only in this subset of patients
Authors: Philippe Lewalle, Anne Soree, Caroline Jacquy, Agnès Triffet, Dominique Bron, Philippe Martial, Frédéric Lambert
Journal: Blood (2001)
Antisocial behavior of intravenous drug abusers: implications for diagnosis of antisocial personality disorder
Authors: R K Brooner, C W Schmidt, L J Felch, G E Bigelow
Journal: American Journal of Psychiatry (1992)

A pattern of chronic adult antisocial behavior is not sufficient for the DSM-III-R diagnosis of antisocial personality disorder unless the early-onset criteria are satisfied, even if the adult criteria are met. The utility of the early-onset requirement for the diagnosis was examined in intravenous drug abusers, a population known to have high rates of irresponsible, aggressive, and criminal behavior.The subjects were 237 drug abusers who had volunteered for an outpatient study of psychopathology and HIV risk behavior and infection. They completed a structured psychiatric interview as part of their participation in that study. The adult antisocial behavior of the group that met both the early-onset and the adult criteria for antisocial personality disorder, the group that met only the adult criteria, and the group that met neither the early-onset nor the adult criteria was then compared.Antisocial personality disorder (meeting the early-onset and adult criteria) was diagnosed in 44% of the sample; an additional 24% met only the adult criteria. The group with the diagnosis of antisocial personality disorder reported a more pervasive and more serious pattern of adult antisocial behavior than did the other groups, although antisocial behavior was commonplace in all three groups.Early onset of multiple antisocial behaviors identified a subset of drug abusers with important differences in the extent and severity of their adult antisocial behavior. The antisocial behavior of the group that met only the adult criteria suggests the possibility of a late-onset and less severe form of antisocial personality disorder.
Abstract 15722: Epigenetic Modifiers Attenuate Inflammation and Improve Survival in Sepsis
Authors: Jayakumar Thangavel, Alagarsamy L Reddi, Buddhadeb Dawn, Asrar B Malik, Johnson Rajasingh
Journal: Circulation (2011)

BACKGROUND and OBJECTIVE: Sepsis is a systemic inflammatory disorder, and its progression to septic shock is a serious clinical problem with very high mortality of 40%. We investigated whether epig...
Durable Remissions in Acquired Hemophilia Patients with Inhibitor-Titer-Based Tailoring of Treatment Strategy Optimizing Rituximab Usuage – a Case Series from Single Institution in Saudi Arabia
Authors: Syed Ziauddin A. Zaidi, Shahid Iqbal, Imran Khan Tailor, Ibraheem H Motabi, Nawal F Al-Shehry, Assem Abdelkhalik Elghazaly, Samer Al-Mudaibigh, AbdulRehman Z Zaidi, Abdulaziz Al-Humaidi
Journal: Blood (2014)