tbuckley/cabot-search huggingface dataset:
Abstract 4109: First experiences for Pulmonary Vein Isolation with the High Density Mesh Ablator
Authors: Axel Meissner, Gunnar Plehn, Marc van Bracht, Martin Christ, Thomas Butz, Petra Maagh, Rolf Borchard, Hans-Joachim Trappe
Journal: Circulation (2008)

Interventional therapy of atrial fibrillation (AF) still is a complex procedure often associated with long examination- and fluoroscopy times. The use of mapping catheters in addition to the ablation catheter requires multiple transseptal sheats for left atrial access. The purpose of this prospective study was to evaluate feasibility and safety of pulmonary vein (PV) isolation using the high density mesh ablator (HDMA), a novel single, expandable electrode catheter for both mapping and radiofrequency (RF) delivery at the left atrium/PV junctions. 26 patients (PTS) with highly symptomatic paroxysmal AF (14, 53.8%) and persistent AF (12, 46.2%) were studied. Segmental PV isolation via the HDMA was performed using a customized pulsed RF energy delivery program (target temperature 55– 60 degrees, power 70 –100 Watt, 600 –900 seconds RFapplication time/PV). All 104 PV in 26 PTS could successfully be ablated by the HDMA. Segmental PV isolation was achieved with a mean of 3.25±1.4 RF applications for a mean of 603±185 sec. Entrance conduction block was obtained in &gt;94% of all PV. Mean total procedure and fluoroscopy time was 159.0±32 min and 33.5±8.6 min respectively. None of the PTS experienced severe complications. In this first study of PV isolation using the HDMA, our findings suggest that this method is safe and yields good primary success rates. Anatomical orientation and signal quality were good, allowing for excellent electrophysiological control. The HDMA simplifies the complex procedure of AF ablation, favorably impacting procedure and fluoroscopy times. Further studies are required to assess the long-term outcome.
Abstract 5506: ATP Released During Hypoxia/Reoxygenation Activates A P2Y Receptor Mediated Survival Mechanism In Human Endothelial Cells
Authors: Daniel Urban, Frauke V Haertel, Krishnaveni Gadiraju, H. M Piper, Thomas Noll
Journal: Circulation (2008)

Introduction: Recently we have shown that ATP passes the endothelial cell membrane via Connexin43 hemichannels during hypoxia/reoxygenation (H/R). Here we hypothesized that extracellular ATP protects endothelial cells (EC) against ongoing apoptotic cell death during H/R by activating an autocrine signaling mechanism mediated by purine receptors.  Methods and Results: In cultured human umbilical vein EC a robust apoptosis was induced by serum deprivation. Subsequently, cells were exposed to 2 hrs of hypoxia (Po2  Conclusion: The data of the present study show that hypoxia induces ATP release via Cx43 hemichannels in EC. The extracellular ATP protects EC against ongoing apoptotic cell death by activating an autocrine survival mechanism. This protective mechanism is due to a P2Y receptor mediated signaling involving the MEK/ERK pathway.
The cost burden of trastuzumab and bevacizumab monoclonal antibody therapy in solid tumors: Can we afford it?
Authors: A. Drucker, K. Virik, C. Skedgel, D. Rayson, M. Sellon, T. Younis
Journal: Journal of Clinical Oncology (2006)

6044 Background: Monoclonal antibodies (MAb), such as trastuzumab (TZ) and bevacizumab (BZ), have become an important yet expensive component of cancer treatment. The potential cost impact on health care budgets needs to be assessed in the context of its potential utilization. An estimate of the additional costs incurred by adopting TZ and BZ therapy in breast (BRC), lung (LUC) and colorectal (CRC) cancers was undertaken. Methods: The MAb costs per patient were estimated based on treatment indications, length of treatment, standard doses / schedules and local pharmacy data. Supportive medications, diagnostics and health resources utilization only required for the MAb therapy were also examined. This analysis was performed in Canadian dollars ($), and assumes complete drug delivery and uncomplicated cycles. Drug costs were based on average 2005 wholesale prices in Canada. The analysis took a direct payer perspective. We subsequently estimated the cost of MAb therapy per patient relative to the total costs of conventional cancer management without MAb therapy. Budget impact estimates on Canada’s health care system were then derived according to constructed schema, which accounts for absolute numbers of target patients and systemic therapy utilization. Results: The average costs of TZ per treated patient were $47,278 and $26,648 for adjuvant and metastatic BRC, respectively. For BZ, these were $47,250 and $38,500 for metastatic LUC and CRC, respectively. Other costs associated with MAb therapy were in the range of 3–6%. The predicted TZ drug costs in metastatic breast cancer were within 10% of the actual costs derived from pharmacy data. The potential life-time absolute costs to Canada’s health care system were approximately $118 million for TZ, and $262 million for BZ. This corresponds to an average of approximately 21% increase in the health care expenditure for BRC, LUC, and CRC. Conclusions: MAb therapy, such as TZ and BZ, may add a significant cost burden to Canada’s publicly funded health care system. The developed schema in this analysis may be of potential use to health care providers and policy makers in assessing the impact of MAb therapy on health care budgets. No significant financial relationships to disclose.
Abstract 5888: Activation of Peroxisome Proliferator-activated Receptor {alpha} in Megakaryocytes Reduces the Expression of Platelet-drived Growth Factor-BB in Platelets
Authors: Shunji Hashizume, Masashi Akaike, Hiroyuki Azuma, Kazue Ishikawa, Sumiko Yoshida, Yuka Ueta, Shusuke Yagi, Yasumasa Ikeda, Takashi Iwase, Ken-ichi Aihara, Masataka Sata, Toshio Matsumoto
Journal: Circulation (2009)

Background: Platelet-derived growth factor (PDGF)-BB released from activated platelets at sites of injured vascular endothelium caused the proliferation and migration of vascular smooth muscle cell...
Prothrombotic genetic risk factors are associated with an increased risk of liver fibrosis in the general population
Authors: Elisabeth P.C. Plompen, Sarwa Darwish Murad, Bettina E. Hansen, Daan W. Loth, Jeoffrey N.L. Schouten, Pavel Taimr, Albert Hofman, André G. Uitterlinden, Bruno H. Stricker, Harry L.A. Janssen, Frank W.G. Leebeek
Journal: Journal of Hepatology (2015)
Ocular Manifestations of Xeroderma Pigmentosum
Authors: Brian P. Brooks, Amy H. Thompson, Rachel J. Bishop, Janine A. Clayton, Chi-Chao Chan, Ekaterini T. Tsilou, Wadih M. Zein, Deborah Tamura, Sikandar G. Khan, Takahiro Ueda, Jennifer Boyle, Kyu-Seon Oh, Kyoko Imoto, Hiroki Inui, Shin-Ichi Moriwaki, Steffen Emmert, Nicholas T. Iliff, Porcia Bradford, John J. DiGiovanna, Kenneth H. Kraemer
Journal: Ophthalmology (2013)
Aspirin Therapy
Authors: Janet M. Torpy, Edward H. Livingston
Journal: JAMA (2013)

Aspirin TherapyA spirin, also known as acetylsalicylic acid, has been used for many years to relieve pain, reduce fevers, and improve inflammation.Aspirin is one of the nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, naproxen, meloxicam, and ketorolac.Another important effect of aspirin is its ability to make the blood less likely to clot.Aspirin does this by acting on the blood's platelets and interrupting the way the platelets work in the body's clotting system.
Epidemiological surveillance of West Nile neuroinvasive diseases in Italy, 2008 to 2011
Authors: C Rizzo, P Salcuni, L Nicoletti, M G Ciufolini, F Russo, R Masala, O Frongia, A C Finarelli, M Gramegna, L Gallo, M G Pompa, G Rezza, S Salmaso, S Declich
Journal: Eurosurveillance (2012)

We describe the geographical and temporal distribution of West Nile neuroinvasive diseases (WNND) cases in Italy from 2008 to 2011. The increasing number of confirmed human cases from eight in 2008 to 18 in 2009 and the occurrence of the virus in a larger geographical area in 2009 (moving from east to west) prompted the Ministry of Health to publish, in spring 2010, a national programme for WNND human surveillance, comprising veterinary and vector surveillance. Subsequently, in 2011, a new national plan on integrated human surveillance of imported and autochthonous vector-borne diseases (chikungunya, dengue and West Nile disease) was issued. Between 2008 and 2011, 43 cases of WNND were reported from five regions in Italy with a case fatality rate of 16%. The incidence of WNND during the entire study period was 0.55 per 100,000 population (range: 0.06–0.23 per 100,000). During 2011, two new regions (Friuli-Venezia Giulia and Sardinia) reported confirmed cases in humans. Integrated human, entomological and animal surveillance for West Nile virus is a public health priority in Italy and will be maintained during 2012.
Abstract 15090: Coronary Computed Tomography Provides Local SYNTAX Scores for Complex Culprit Lesions Correlating with Angiography
Authors: Barbara E Stähli, Francesca Bonassin, Robert Goetti, Silke M Küest, Lukas A Altwegg, Manfred B Wischnewsky, Thomas F Lüscher, Hatem Alkadhi, Philipp A Kaufmann, Willibald Maier
Journal: Circulation (2011)

Introduction: Coronary computed tomography angiography (CCTA) is increasingly used to exclude significant coronary artery disease non-invasively. Experience about its potential for guiding percutan...
Abstract 16061: Lymphatic Abnormalities in Patients With Congenital Heart Disease: New Insights From Non-Contrast Magnetic Resonance Lymphangiography
Authors: Yoav Dori, Jack Rychik, Andrew C Glatz, Matthew J Gillespie, Matthew A Harris, Mark Fogel, Kevin K Whitehead, Jonathan J Rome, Marc Keller, Maxim Itkin
Journal: Circulation (2013)

Background: Lymphatic abnormalities are thought to play a key role in 2 often fatal complications of Fontan physiology: protein losing enteropathy (PLE) and plastic bronchitis (PB). However, the pr...
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor
Authors: William D. Tap, Zev A. Wainberg, Stephen P. Anthony, Prabha N. Ibrahim, Chao Zhang, John H. Healey, Bartosz Chmielowski, Arthur P. Staddon, Allen Lee Cohn, Geoffrey I. Shapiro, Vicki L. Keedy, Arun S. Singh, Igor Puzanov, Eunice L. Kwak, Andrew J. Wagner, Daniel D. Von Hoff, Glen J. Weiss, Ramesh K. Ramanathan, Jiazhong Zhang, Gaston Habets, Ying Zhang, Elizabeth A. Burton, Gary Visor, Laura Sanftner, Paul Severson, Hoa Nguyen, Marie J. Kim, Adhirai Marimuthu, Garson Tsang, Rafe Shellooe, Carolyn Gee, Brian L. West, Peter Hirth, Keith Nolop, Matt van de Rijn, Henry H. Hsu, Charles Peterfy, Paul S. Lin, Sandra Tong-Starksen, Gideon Bollag
Journal: New England Journal of Medicine (2015)

Expression of the colony-stimulating factor 1 (CSF1) gene is elevated in most tenosynovial giant-cell tumors. This observation has led to the discovery and clinical development of therapy targeting the CSF1 receptor (CSF1R).Using x-ray co-crystallography to guide our drug-discovery research, we generated a potent, selective CSF1R inhibitor, PLX3397, that traps the kinase in the autoinhibited conformation. We then conducted a multicenter, phase 1 trial in two parts to analyze this compound. In the first part, we evaluated escalations in the dose of PLX3397 that was administered orally in patients with solid tumors (dose-escalation study). In the second part, we evaluated PLX3397 at the chosen phase 2 dose in an extension cohort of patients with tenosynovial giant-cell tumors (extension study). Pharmacokinetic and tumor responses in the enrolled patients were assessed, and CSF1 in situ hybridization was performed to confirm the mechanism of action of PLX3397 and that the pattern of CSF1 expression was consistent with the pathological features of tenosynovial giant-cell tumor.A total of 41 patients were enrolled in the dose-escalation study, and an additional 23 patients were enrolled in the extension study. The chosen phase 2 dose of PLX3397 was 1000 mg per day. In the extension study, 12 patients with tenosynovial giant-cell tumors had a partial response and 7 patients had stable disease. Responses usually occurred within the first 4 months of treatment, and the median duration of response exceeded 8 months. The most common adverse events included fatigue, change in hair color, nausea, dysgeusia, and periorbital edema; adverse events rarely led to discontinuation of treatment.Treatment of tenosynovial giant-cell tumors with PLX3397 resulted in a prolonged regression in tumor volume in most patients. (Funded by Plexxikon; ClinicalTrials.gov number, NCT01004861.).
Action on antimicrobial resistance
Authors: R. Smith
Journal: BMJ (1998)

“We screwed up, and we ought to say so and apologise. Doctors were handed the wonderful gift of antibiotics but are destroying them through indiscriminate use. We don't need another committee. We know what to do: we should just use them less.” So spoke Norman Simmons, emeritus consultant microbiologist from Guy's Hospital, London, to a tremendous round of applause at last week's panEuropean meeting in Copenhagen on antimicrobial resistance.

Increasing resistance to antimicrobial agents is health care's version of global warming. The serious problems are global and lie in the future. Evidence is uncertain. There is no technical fix. An adequate response depends on ordinary doctors and patients changing their everyday practices. We may have to give up …
Norwegian public health investigation shows that antibiotic resistance concerns us all
Authors: Ulf R Dahle, Charlotte Ulstad, Sophie Berg
Journal: BMJ (2015)

We agree with Tonkin-Crine and colleagues that the use of behavioural science to tackle antibiotic prescribing is welcome.1

This past year, chicken consumption has dropped in Norway (by 20% for some distributors) mainly because of findings of resistant Escherichia coli in chicken meat. Assurances that kitchen hygiene and heat treatment render the meat harmless did …
Abstract 15198: Levels of Platelet-Derived Microparticles Are Related to Angiographic No-Reflow Phenomenon in Patients With ST-Elevation Myocardial Infarction Undergoing Primary-PCI
Authors: Luigi M Biasucci, Italo Porto, Giovanni L De Maria, Luca Di Vito, Francesco Burzotta, Alessandra Tritarelli, Gustapane Massimo, Claudia Camaioni, Giorgio Cautilli, Filippo Crea
Journal: Circulation (2010)

Purpose: Platelet-derived-microparticles (PMP) are fragments ranging 0.1-1 μm, released by platelets and elevated in patients with acute coronary syndromes (ACS). PMP levels are increased in ST-ele...
Abstract 17243: Increased Survival in Patients with Right Ventricular Pacemakers Treated with Renin-Angiotensin-Aldosterone System Blockade
Authors: Douglas Elder, Chim C Lang, Anna-Maria Choy
Journal: Circulation (2011)

Background: Right ventricular apical pacing can cause ventricular dyssynchrony and pacing-induced heart disease that is associated with worse cardiovascular outcomes. In an animal pacing model angiotensin converting enzyme inhibitors (ACEI) diminished left ventricular dyssynchrony reduction in afterload and left-ventricular wall stress and reduction in myocardial fibrosis. The impact of ACEI in paced patients is unknown. Objectives: To investigate the impact of ACEI/ARB on survival in a retrospective observational study of paced patients. Methods: The Tayside Pacemaker Registry was linked to dispensed prescribing, laboratory, echocardiography, hospital admission data as well as and the national death registry. All patients undergoing right ventricular pacemaker insertion between 1994 and 2009 who had never received ACE-I/ARB prior to pacing were included. Patients with heart failure prior to implant were excluded. Cox regression was used to assess differences in all-cause mortality between those on ACE-I/ARB versus those who had never received ACE-I/ARB, adjusted for confounding variables. A propensity score matched analysis was performed to minimise bias. Results: 3815 patients implanted between 1994 and 2008, 1186 (median age 78, range 18-103yrs, 53% males) met inclusion criteria (63% DDD and 37% VVI). Mean follow-up was 5.3 ± 4.0 years with 484 (41%) deaths. ACEI/ARB was associated with significantly reduced mortality (adjusted HR 0.68, 95%CI [0.54-0.87],p&lt;0.001). In a propensity score matched analysis of 805 individuals the HR was (0.57, 95%CI [0.46-0.71], p=0.001). Conclusions: This study suggests prescription of ACEI/ARBs may confer benefits on survival in patients with right ventricular pacemakers.
Do doctors read forms? A one-year audit of medical certificates submitted to a crematorium
Authors: J Stuart Horner, Jonathan W Horner
Journal: Journal of the Royal Society of Medicine (1998)

To determine the thoroughness and accuracy with which medical certificates for cremation are completed, a record was made, during normal processing of the documents, of the number of questions that were not answered or answered wrongly, or in which clarification was required. Of 835 sets of forms only 346 (41%) were completed sufficiently accurately for the cremation to proceed without further enquiry. Junior doctors contributed the most errors but general practitioners and consultants also contributed large numbers of errors. Doctors ought to be far more accurate and thorough in completing cremation certificates than were those audited here. The results cast doubt on the reliability of information supplied on other forms. In view of the high frequency of poorly completed forms, review by a medical referee remains essential.
Abstract 15616: Nicotine delays the Development of Cardiac Conduction System: Potential Cause for Arrhythmias leading to Sudden Infant Death Syndrome
Authors: Anh-Tuan Ton, Jean-Francois Delabre, Michael Biet, Nathalie Morin, Robert Dumaine
Journal: Circulation (2011)

Introduction: More than 50% of newborns death is due to the sudden infant death syndrome (SIDS). Exposure to cigarette smoke represents the highest risk factor for SIDS. Cardiac bradycardias are ob...
Body mass index and quality of life in patients with asthma
Authors: Galina Sergeeva, Alexander Emelyanov
Journal: European Respiratory Journal (2011)

Background:  We examined the effect of overweight and obesity on quality of life in patients with asthma.   Methods:  Two hundred out-patients with asthma (aged 18 - 80 yrs, mean age 55 yrs, 33% males) were divided into 3 groups: with normal body mass index (BMI   Results:  Fifty eight percent of males and in 69% of females with asthma had BMI≥25: 35% of males and females were overweight and 23% males and 34% females were obese. BMI in males was 26.8±0.62, in females – 28.9±0.55 (p   Conclusion:  Obesity and overweight are frequently associated with asthma. There was a significant correlation between BMI≥25 and Activity, Impact and Total items of SGRQ.
Abstract 20419: Citrullination in Actin-Tropomyosin-Myosin Complex: Novel Regulatory Mechanism
Authors: Justyna Fert-Bober, Jennifer Van Eyk
Journal: Circulation (2014)

Background:  A novel protein post-translational modification, citrullination was shown previously in a number of key myofilament proteins, tropomyosin (R 133, R 238), actin (R 39) and myosin heavy chain (R 1176, 1303, 1434) in HF patient (values for total spectra counts for citrullinated proteins in control, ISHD and IDCM: 1.8 ±1.3, 3.2±2.7 and 2.3±1.9, respectively). The alterations in contractile proteins underlying enhanced Ca2+-sensitivity of the contractile apparatus in end-stage failing human myocardium are still not resolved. Protein citrullination arises from the enzymatic conversion of arginine residues to citrulline result in loss of a positive charge and reduction in hydrogen-bonding ability. And here, the biophysical and biochemical effect on myofilament function is determined.   Method:  F-actin-tropomyosin binding, tropomyosin-actin-myosin, actin-myosin and myosin ATPase activity assays, and F-actin stability assays were carried out.   Results:  In vitro citrullinated tropomyosin significantly enhance affinity for F-actin (p=0.001) and decrease in the ATPase activity (p=0.06). Furthermore, citrullination of myosin HMM is not essential for actin affinity, although it modulate ATPase activation (p=0.3). Contrary, the ATPase activity is increase by pretreatment of actin (but not myosin) with PAD2 (p=0.09).   Conclusion:  Citrullination of the contractile proteins could affect different aspects of regulatory function. It either triggers a structural change or stabilizes a conformation that is necessary for actin-activated release of Pi and completion of the ATPase cycle.   Significance:  Citrullination of specific myofilament proteins in HF can have dramatic effect on modulating actin filament integrity and myosin function and tropomyosin action on myofilament regulation.
Drug points: Allopurinol interaction with cyclosporin
Authors: M Gorrie, M Beaman, A Nicholls, P Blackwell
Journal: BMJ (1994)

We report a potentially serious interaction between allopurinol and cyclosporin which has not previously been reported in the United Kingdom (Sandoz Pharmaceuticals,personal communication). A 27 year old woman whose renal transplant had been stable for 11 years had received maintenance doses of cyclosporin since 1990. For 18 …
Abstract 18287: Transapical Aortic Valve Implantation Compares Favourably to Conventional Aortic Valve Replacement in High-Risk Patients with Severe Aortic Stenosis and Previous Coronary Artery Bypass Grafting
Authors: Sandro Sponga, Josep Rodes Cabau, Daniel Doyle, Robert De Larochelliere, Rodrigo Bagur, Eric Dumont
Journal: Circulation (2010)

Background: Conventional surgical aortic valve replacement (SAVR) in patients with previous coronary artery bypass grafting has been associated with a higher risk. Transcatheter transapical aortic ...
Abstract 14662: Loss of the eIf2 Kinase GCN2 Protects Mice From Pressure Overload Induced Congestive Heart Failure
Authors: Zhongbing Lu, Xin Xu, Xinli Hu, Haipeng Guo, Dachun Xu, Robert J Bache, Yingjie Chen
Journal: Circulation (2011)

Nutrient deprivation or stress enhances phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2α) to selectively attenuate mRNA translation through General Control Nonderepress...
Serum Albumin Level &lt; 32 g/l on Day 30 Can Predicts Higher Risk of Non-Relapse Mortality in Acute Lymphoblastic Leukemia Following Allogeneic Stem Cell Transplantation
Authors: Feras Alfraih, Vikas Gupta, John Kuruvilla, Jeffrey H. Lipton, Hans A. Messner, Matthew D. Seftel, Jieun Uhm, Dennis Dong Hwan Kim
Journal: Blood (2014)
Abstract 1905: Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) Study: Age Analysis Reveals T3 Benefit in Youngest Patients
Authors: Michael A Portman, Aaron K Olson, April Slee, Gordon Cohen, Tom Karl, Elizabeth Tong, Laura Hastings, Hitendra Patel, Olaf Reinhartz, Antonio R Mott, Richard Mainwairing, Sara Danzi, Tricc Investigators
Journal: Circulation (2009)