tbuckley/cabot-search huggingface dataset:
Vascular responses after alpha adrenergic receptor blockade
Authors: Francois M. Abboud, John W. Eckstein
Journal: Journal of Clinical Investigation (1968)

The effects of nerve stimulation and of intraarterial injections of norepinephrine on arterial and venous resistances were studied in the perfused forelimb of dog before and after administration of the alpha adrenergic receptor blocker phenoxybenzamine.Pressures were recorded from the perfused brachial artery and a small metacarpal vein in the forepaw. Blood flow to the whole forelimb was maintained constant. Changes in perfusion pressure in the brachial artery reflected primarily changes in arterial resistance and changes in small vein pressure reflected changes in resistance of venous segments downstream from the point of pressure measurement.Alpha receptor blockade reduced vasoconstrictor responses to both nerve stimulation and norepinephrine. Responses to angiotensin, used in these experiments as an internal control, were not blocked consistently in a dose-related manner indicating that the effects of phenoxybenzamine were specific to adrenergic stimuli.Increases in venous pressure in response to norepinephrine and to nerve stimulation were blocked almost completely whereas increases in arterial pressure were reduced only in part by the blocker. The more effective reduction of pressor responses in the small vein was not caused by a passive reduction in blood flow through the paw nor was it caused by a reduction in the concentration of norepinephrine in the venous effluent reaching the venous segments.This differential effect of alpha receptor blockade on increases in venous and arterial resistances may account for the beneficial effect of phenoxybenzamine in shock.
The Effect of Electromagnetic Field Generated by a Mobile Phone on the Performance of a SPECT Scanner
Authors: Ali Mahmoud Pashazadeh, Forough Jafarian Dehkordi, Kaveh Tanha, Majid Assadi
Journal: Clinical Nuclear Medicine (2015)

The aim of the current attempt was quantitative investigation of the electromagnetic interference (EMI) of a mobile phone with the function of a SPECT gamma camera during data acquisition.We tested the effect of a mobile phone, in both ringing mode and standby mode, on one SPECT gamma camera during scanning a cylindrical phantom containing 5.4 mCi (99m)Tc. The experiment was performed for different distances of 10, 12, 14, 16, 18, 20, 25, and 30 cm between mobile phone and head of the scanner, and for different head angles of 0, 30, 60, 90, 120, 150, and 180 degrees. A RF-EMF meter measured strength of electromagnetic field throughout the study. Statistically significant decrease in count number was considered to be electromagnetic interference.There was significant reduction in the recorded counts during ringing of the mobile phone in all studied distances. For gamma camera, fixed at a distance, there was no uniform pattern of reduction of the counts at different angles between two operation modes of the mobile phone.A mobile phone, at close distance, can be a sensible source of electromagnetic field, disturbing the normal function of a gamma camera.
Determinants of Low Bone Mineral Density after Childhood Cancer
Authors: Marissa den Hoed, Bibi C. Klap, Mariël L. Te Winkel, Lisette Stolk, Rob Pieters, Marjolein van Waas, Sebastian J.C.M.M. Neggers, Karin Blijdorp, Wendy van Dorp, A.M. Boot, S.M.F. Pluijm, Marry M. van den Heuvel-Eibrink
Journal: Blood (2014)
O110 : Simeprevir + sofosbuvir combination therapy for recurrent genotype-1 hepatitis C in liver transplant recipients : A real-life multicenter experience
Authors: H. Te, J. Ahn, T. Schiano, A. Diesing, A. Aronsohn, S. Robertazzi, L Myers, R. Satoskar
Journal: Journal of Hepatology (2015)
TREATMENT OF CHRONIC RHEUMATOID ARTHRITIS; FURTHER OBSERVATIONS ON THE USE OF STREPTOCOCCAL VACCINE
Authors: Charles W. Wainwright
Journal: Annals of Internal Medicine (1935)

Article1 September 1935TREATMENT OF CHRONIC RHEUMATOID ARTHRITIS; FURTHER OBSERVATIONS ON THE USE OF STREPTOCOCCAL VACCINECHARLES W. WAINWRIGHT, M.D., F.A.C.P.CHARLES W. WAINWRIGHT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-3-245 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous communication I1have reported the results of attempts to confirm the blood culture studies of Cecil, Nicholls and Stainsby2in cases of chronic rheumatoid arthritis. The technic of these investigators was followed in detail except for two minor variations which were devised to lessen the chances of contamination. In but a single instance were streptococci recovered from either the blood stream or the joint fluids so cultured. These results did not substantiate those of Cecil, Nicholls and Stainsby and others, who report the presence of streptococci in the blood stream of 50 per cent or more of...Bibliography1. WAINWRIGHT CW: Treatment of chronic rheumatoid arthritis with streptococcus vaccine on basis of skin sensitivity, Jr. Am. Med. Assoc., 1934, ciii, 1357-1361. CrossrefGoogle Scholar2. CECILNICHOLLSSTAINSBY RLEEWJ: Bacteriology of blood and joints in chronic infectious arthritis, Arch. Int. Med., 1929, xliii, 571-605. CrossrefGoogle Scholar3. DAWSONOLMSTEADBOOTS MHMRH: Bacteriologic investigations on blood, synovial fluid and subcutaneous nodules in rheumatoid (chronic infectious) arthritis, Arch. Int. Med., 1932, xlix, 173-180. CrossrefGoogle Scholar4. DAWSONOLMSTEADBOOTS MHMRH: Agglutination reactions in rheumatoid arthritis, Jr. Immunol., 1932, xxiii, 187-204. Google Scholar5. NICHOLLSSTAINSBY EEWJ: Streptococcal agglutinins in chronic infectious arthritis, Jr. Clin. Invest., 1931, x, 323-335. CrossrefGoogle Scholar6. KEEFERMYERSOPPEL CSWKTW: Streptococcal agglutinins with rheumatoid (atrophic) arthritis and acute rheumatic fever, Jr. Clin. Invest., 1933, xii, 267-277. CrossrefGoogle Scholar7. MYERSKEEFERHOLMES WKCSWF: Resistance to fibrinolytic activity of hemolytic streptococcus with special reference to patients with rheumatic fever and rheumatoid (atrophic) arthritis, Jr. Clin. Invest., 1935, xiv, 119-123. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Read at the Philadelphia meeting of the American College of Physicians, May 1, 1935. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Influence of Hypersensitivity on Endogenous Uveal Disease*Allergie und Rheumatismus 1 September 1935Volume 9, Issue 3Page: 245-251KeywordsBloodRheumatoid arthritisRiversVaccines ePublished: 1 December 2008 Issue Published: 1 September 1935 PDF downloadLoading ...
DEVELOPMENTS AND DISAPPOINTMENTS IN BLOOD STUDIES
Authors: Roger I. Lee
Journal: Annals of Internal Medicine (1934)

Article1 June 1934DEVELOPMENTS AND DISAPPOINTMENTS IN BLOOD STUDIESROGER I. LEE, M.D., F.A.C.P.ROGER I. LEE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-12-1496 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSomewhat over a medical generation ago, or at the beginning of the present century, the study of blood entered on what seemed to be a remarkably promising era. Hitherto, careful and exact studies of organs and tissues had been carried out largely after death. However, the advances in surgery were encouraging the development of a living pathology in contrast to a postmortem pathology. The internist was eager to study at the bedside the beginnings of disease, rather than to confine his attention to the study of end results in the autopsy room. The possibilities of living studies were obvious and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read before the American College of Physicians, Chicago, April 16, 1934. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1934Volume 7, Issue 12Page: 1496-1502KeywordsAutopsyBloodSurgery ePublished: 1 December 2008 Issue Published: 1 June 1934 PDF downloadLoading ...
Abstract 5663: Imatinib Inhibits Proliferation and Migration and Induces Apoptosis in Pulmonary Artery Smooth Muscle Cells From Patients With Idiopathic Pulmonary Arterial Hypertension
Authors: Kazufumi Nakamura, Satoshi Akagi, Hiromi Matsubara, Aiko Ogawa, Aya Miura, Daiji Miura, Nobuhiro Nishii, Satoshi Nagase, Hiroshi Morita, Yoshiki Hata, Kengo F Kusano, Hiroshi Ito
Journal: Circulation (2009)

Background : Idiopathic pulmonary arterial hypertension (IPAH) is characterized by inappropriate increase of pulmonary artery smooth muscle cells (PASMCs). We assessed the inhibitory effects of imatinib, a platelet-derived growth factor (PDGF)-receptor tyrosine kinase inhibitor, on PDGF-induced proliferation and migration of PASMCs obtained from patients with IPAH, and investigated whether imatinib induces apoptosis of PASMCs. Methods and Results : PASMCs were obtained from 7 patients with IPAH undergoing lung transplantation. PDGF (10 ng/mL) stimulation caused a higher growth rate of PASMCs from patients with IPAH than that of normal control PASMCs (n=6) as assessed by 3 H-thymidine incorporation (normal: 179±45 vs. IPAH: 310±31 % of counts before PDGF, P &lt;0.05). After treatment with imatinib (0.1 and 1 μ g/mL), PDGF-induced cell proliferation of PASMCs from IPAH patients decreased by 51% and 90 % respectively (PDGF vs PDGF+imatinib (0.1 and 1 μ g/mL): P &lt;0.001). Western blot analysis revealed that imatinib (1 μ g/mL) increased the expression of cyclin-dependent kinase inhibitor p27 in IPAH-PASMCs compared with treatment with PDGF (53%; PDGF vs. PDGF+imatinib, P &lt;0.005). A time-lapse system revealed that PDGF increased the migration distance of IPAH-PASMCs compared to that of normal PASMCs ( P &lt;0.0001), and imatinib (1 μ g/mL) inhibited PDGF-induced migration ( P &lt;0.0001). TUNEL assay revealed that imatinib (1 μ g/mL) alone did not induce apoptosis in IPAH-PASMCs, but combination of imatinib and PDGF increased apoptotic cells (Figure ). Conclusions: Inhibition of PDGF signaling by imatinib may become a useful molecular-targeted therapy for IPAH. Figure. Effect of imatinib on apoptosis of PASMICs in Tunnel assay.
Abstract P338: Differences in Costs, Length of Stay and Mortality for Myocardial Infarction and Related Disorders in Non Federal Hospitals
Authors: Priscilla O Okunji, Anthony K Wutoh
Journal: Circulation (2012)

BACKGROUND: Validated estimates of costs, length of stay, and mortality rates are necessary for the treatment and prevention of acute myocardial infarction in patient admitted to federal hospitals. Estimates based on data from few healthcare institutions may not be generalizable to all hospitals. HYPOTHESIS: To assess the hypothesis that there will be significant differences in costs, length of stay, and in-hospital mortality rates between inpatient with: (1) acute myocardial infarction only, (2) diabetic acute myocardial infarction and (3) diabetes only in non federal hospitals. METHODS: Data were extracted and analyzed from 4,400 hospital patients with both diabetes and myocardial infarction using International Classification of Diseases-9-Clinical Modification (ICD 9-CM) primary diagnosis codes from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample database. Data were retrospectively extracted from 1,056 hospitals in 42 States. Descriptive and multivariate statistical techniques were used to examine patient characteristics and outcome-related factors associated with the inpatient costs. RESULTS: Patients with acute myocardial infarction only incurred the highest average cost ($68,036, n = 24,791), followed by patients with diabetic myocardial infarction ($65,937, n = 4,400), and diabetes only ($33,680, n = 1,021,933) in 2008 hospital stay. The average LOS was at 6.3 days for myocardial infarction, 7.5 days for diabetic myocardial infarction, 4.95 days for diabetes. Inpatient with myocardial infarction only 2,056 (8.2%), diabetic myocardial infarction 350 (7.9%) and diabetes only 25,377 (2.5%) died during hospitalization. Regression analysis showed that patient comorbidities for both diabetic myocardial infarction were highly significant at p &lt; .0001 ranking from fluid and electrolyte 306 (6.0%), renal failure 558 (12.6%), peripheral vascular disorders 363 (8.2%) and congestive heart failure 306 (6.0%). For each procedure, as days from admission to the first procedure increased, average costs consistently decreased ranging from less than one day ($11, 681.00) to 9 days ($100.00). Also, average costs were significantly high, p &lt; .0001 with patient location, patient disposition, risk mortality and disease severity. Patient gender and ethnicity were also significant, p &lt; .005 and p &lt;.006 respectively. CONCLUSIONS: In conclusion, acute myocardial infarction remains the index for increased inpatient mortality, costs and length of stay in patients with both diabetes and myocardial infarction. Inpatients outcomes could be decreased enormously if patient could be screened and treated appropriately on admission to prevent complications like acute myocardial infarction. This study has revealed that appropriate estimation of costs in acute myocardial infarction disorders would help in accurate allocation of funds for preventive measures.
Case Finding in Tuberculosis
Authors: D. R. Nagpaul
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2549: Unexpected High Incidence of Esophageal Injury After Pulmonary Vein Isolation Using Mechanical Navigation
Authors: Roland R Tilz, Kyoung R Chun, Andreas Metzner, Andre Burchard, Dieter Nuyens, Tom De Potter, Kars Neven, Alexander Fuernkranz, Feifan Ouyang, Karl Heinz Kuck, Boris Schmidt
Journal: Circulation (2009)

Background:  Mechanical navigation (MN) is a novel technology for pulmonary vein isolation (PVI) treating atrial fibrillation (AF). However, the incidence of thermal esophageal injury using standard power settings is unknown.   Methods and Results:  Thirty-nine patients (pts, 23 male; 60±11 years, LA 44±6mm, hypertension n=27) without history of peptic disease underwent circumferential PVI for AF. Ablation was performed using MN in 14 pts or manually in 25 pts with a 3.5 mm irrigated tip catheter. Standard ablation power settings (30W, 17 ml/min flow, maximal temperature 43°C) were used during ablation along the LA posterior in the manual (n=25) and the MN 1  group (n=4). In these 2 groups, the operator was blinded to the esophageal temperature (T eso ). In the MN 2  group ablation power along the posterior LA wall was reduced to 20W and energy delivery was terminated if T eso  increased to >41°C. Endoscopy was performed at day 2 after PVI. Esophageal lesions were classified as no lesion, minimal thermal lesion (erythema with intact mucosa) and ulceration (hole in the lining of the esophagus). PVI was achieved in all pts. In the manual group no esophageal lesions, minimal lesions and ulcerations were found in 16 (64%), 6 (24%) and 3 (12%) pts, respectively. All 4 pts (100%) in the MN 1  group had an ulceration and one pt developed esopageal perforation requiring covered stent placement at day 14 that was removed at day 81 after PVI. In the MN2 group, no lesion (9 pts, 90%) or a minimal lesion was found (1 pt, 10%).   Conclusion:  A high incidence of thermal injury to the esophagus including an esophageal perforation was noted following irrigated RFC based PVI using MN with standard power settings. Reduction of ablation power to 20 W along the posterior LA wall and termination of energy delivery if T eso  >41°C appears to be safe.
Abstract 2646: Aortic Arch Plaques and Risk of Vascular Events in Subjects Without Prior Stroke
Authors: Cesare Russo, Zhezhen Jin, Ralph L Sacco, Shunichi Homma, Tatjana Rundek, Marco R Di Tullio
Journal: Circulation (2008)

BACKGROUND: Aortic arch plaques (AAP) are a risk factor for cardiovascular embolic events. However, the risk of vascular events associated with AAP in the general population is unclear. AIM: To assess whether AAP detected by transesophageal echocardiography (TEE) are associated with an increased risk of vascular events in a stroke-free cohort. METHODS: The study cohort consisted of stroke-free subjects over age 50 from the Aortic Plaques and Risk of Ischemic Stroke (APRIS) study. AAP were assessed by multiplane TEE, and considered large if ≥ 4 mm in thickness. Vascular events including myocardial infarction, ischemic stroke and vascular death were recorded during the follow-up. The association between AAP and outcomes was assessed by univariate and multivariate Cox proportional hazards models. RESULTS: A group of 209 subjects was studied (mean age 67±9 years; 45% women; 14% whites, 30% blacks, 56% Hispanics). AAP of any size were present in 130 subjects (62%); large AAP in 50 (24%). Subjects with AAP were older (69±8 vs. 63±7 years), had higher systolic BP (146±21 vs.139±20 mmHg), were more often white (19% vs. 8%), smokers (20% vs. 9%) and more frequently had a history of coronary artery disease (26% vs. 14%) than those without AAP (all p&lt;0.05). Lipid parameters, prevalence of atrial fibrillation and diabetes mellitus were not significantly different between the two groups. During the follow up (94±29 months) 30 events occurred (13 myocardial infarctions, 11 ischemic strokes, 6 vascular deaths). After adjustment for other risk factors, AAP of any size were not associated with an increased risk of combined vascular events (HR 1.07, 95% CI 0.44 to 2.56). The same result was observed for large AAP (HR 0.94, CI 0.34 to 2.64). Age (HR 1.05, CI 1.01 to 1.10), body mass index (HR 1.08, CI 1.01 to 1.15) and atrial fibrillation (HR 3.52, CI 1.07 to 11.61) showed independent association with vascular events. In a sub-analysis with ischemic stroke as outcome, neither AAP of any size nor large AAP were associated with an increased risk. CONCLUSIONS: In this cohort without prior stroke, the incidental detection of AAP was not associated with an increased risk of future vascular events. Associated co-factors may affect the AAP-related risk of vascular events reported in previous studies.
TREATMENT OF UNDULANT FEVER; A REPORT OF FIVE CASES TREATED WITH A SPECIFIC POLYVALENT SERUM
Authors: Harrison F. Flippin
Journal: Annals of Internal Medicine (1938)

Article1 August 1938TREATMENT OF UNDULANT FEVER; A REPORT OF FIVE CASES TREATED WITH A SPECIFIC POLYVALENT SERUMHARRISON F. FLIPPIN, M.D.HARRISON F. FLIPPIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-2-232 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe incidence of undulant fever in the United States is steadily on the increase. The United States Public Health Service statistics1 for 1927 show only 112 cases as compared to 2008 reported in 1935. With this increase in the prevalence of the disease we find numerous reports2 dealing with therapy. It is not the purpose of this paper to attempt to evaluate the various forms of treatment but to report five cases of the disease which were effectively treated with a specific polyvalent serum.†The antimelitensis serum used in the treatment of these cases was a sterile polyvalent antiserum of...Bibliography1. Personal communication from the Division of Sanitary Reports and Statistics, United States Public Health Service. Google Scholar2. CARPENTERBOAK CMRA: The treatment of human brucellosis: a review of current therapeutic methods, Medicine, 1936, xv, 103-127. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication October 25, 1937.From the Hematology Section and the Medical Clinic of the Hospital of the University of Pennsylvania.†Antimelitensis serum, Sharp and Dohme Lot No. 85872. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie BrucellosenDie BrucelloseBrucellosis (Undulant Fever, Malta Fever, Bang's Disease, Infectious Abortion of Domestic Animals) 1 August 1938Volume 12, Issue 2Page: 232-235KeywordsFeversHematology and oncologyHospitalsMedical services ePublished: 1 December 2008 Issue Published: 1 August 1938 PDF downloadLoading ...
UK response
Authors: John Tooke
Journal: BMJ (2007)

Ioannidis et al seem to be unaware of major developments in the United Kingdom.1 Countries wishing to revitalise academic medicine might take note of new initiatives arising from a partnership between government and academic leaders. These include major investment in the clinical research base; introduction of a funded clinical academic training pathway; partnership between government and charitable funders; and successful introduction of bodies for strategic coordination of health research—the UK Clinical Research Collaboration, the National Institute for Health Research, and the Office for the Strategic Coordination of Health Research. The opportunities for translational research, speeding the application of research findings for patient benefit, have never been better.
Effect of Local Roentgen Irradiation on the Formation of New Capillaries After Injury
Authors: Ruth M. Merwin, Elizabeth L. Hill
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article Effect of Local Roentgen Irradiation on the Formation of New Capillaries After Injury Get access Ruth M. Merwin, Ruth M. Merwin National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Elizabeth L. Hill Elizabeth L. Hill National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 4, February 1955, Pages 1031–1037, https://doi.org/10.1093/jnci/15.4.1031 Published: 01 February 1955 Article history Received: 01 November 1954 Published: 01 February 1955