tbuckley/cabot-search huggingface dataset:
Abstract 11600: Single-Beat Assessment of Left Ventricular Systolic and Diastolic Function During Atrial Fibrillation using Myocardial Strain and Strain Rate
Authors: Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Noriko Tomita, Shuji Hayashi, Junko Hotchi, Rina Tamai, Daichi Hirota, Yukina Hirata, Mika Bando, Kozue Ogasawara, Akira Takashima, Hiromu Yamazaki, Sachiko Bando, Takayuki Ise, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata
Journal: Circulation (2011)

Introduction: Left ventricular (LV) systolic and diastolic function during atrial fibrillation (AF) remains poorly understood due to the beat-to-beat variability and the clinical assessment is sometimes difficult. We have shown that tissue Doppler parameters at the ratio of the preceding to the prepreceding R-R interval (RR1/RR2) = 1 can be used to assess LV function in AF. Hypothesis: LV systolic and diastolic function can be estimated from a single-beat based on RR1/RR2 in patients with AF using myocardial strain and strain rate. Methods: Twenty-eight AF patients (mean age 66±11 years old) underwent routine echocardiographic study. Longitudinal systolic strain (LS) and diastolic strain rate (DSr) were measured by 2 different methods: 1) LS (figure, white arrow) and DSr (figure, gray arrow) were the average of instantaneous LS and DSr in 15 seconds; 2) single-beat LS and DSr were calculated at RR1/RR2=1. These indexes were compared with simultaneously measured LV pressure parameters by a 5Fr Millar cathe...
Abstract 16824: Aortic Valve Calcium Score as a Predictor For Periprocedural Complications and 1-Year Mortality After Tavi Using the Corevalve and the Sapien XT Device
Authors: Alexander Leber, Markus Kasel, Diethmar Antoni, Ulrich Ebersberger, Ellen Hoffmann
Journal: Circulation (2011)

Background: Percutaneous aortic valve replacement is a novel treatment option for patients with severe aortic stenosis and high risk for conventional surgery due to significant co morbidity. Risk scores for surgical valve replacement failed to accurately predict periprocedural MACE and 1-year mortality and there is an obvious lack of alternative parameters or scores to risk stratify candidates for TAVI.Objective: We sought to determine and analyze the amount of aortic valve calcification derived from preprocedural contrast enhanced CT-scans as a risk factor for subsequent adverse events. Methods: The transfemoral TAVI procedure was performed in 68 patientsusing the CoreValve device and in 60 patients using the Edwards Sapien XT Device. All patients were refused for conventional surgery due to a high perioperative risk. In all patients the aortic valve calcium score was determined from preprocedural ECG-triggered 64-sclice CT scans. Results: The 30-day MACE rate including death, Stroke and MI was 10.7%, one-year mortality was 11.2%. Using linear regression analysis the aortic valve calcium score turned out as the only significant predictor for 30-day MACE and for 1-year Mortality. Patients with a valve calcium score &gt; 750 had a significant lower one- year survival rate compared to patients with scores &lt;750 (56% vs. 95%, p&lt;0.05). In the patient cohort treated with the CoreValve Device the valve calcium-score was strongly associated with the incidence and severity of postprocedural aortic regurgitation (r=0.26, p&lt;0.05), whereas there was no such relation after treatment with the Sapien XT Device. Conclusion: The aortic valve calcification score is significantly associated with severe procedural complications and one year mortality after TAVI. Large amounts of valve calcium pose a high risk for postprocedural aortic regurgitation in patients treated with the CoreValve system but not for patients treated with the balloon expandable Sapien XT device. Thus the aortic valve calcium score may be used for risk stratification before TAVI and may also help to guide the individual device selection in future.
Abstract 9681: Pre-Procedural Serum Albumin and C-reactive Protein Levels Predict Clinical Outcome After Endovascular Therapy in Hemodialysis Patients with Peripheral Artery Disease
Authors: Yoshihiro Kawamura, Hideki Ishii, Kouhei Yoneda, Kazuhiro Kawashima, Daisuke Kamoi, Takashi Sakakibara, Kyuuichi Furuhashi, Toru Aoyama, Yoshitaka Kumada, Hiroshi Takahashi, Miho Tanaka, Toyoaki Murohara
Journal: Circulation (2011)

Background: Although endovascular therapy (EVT) has become widely performed for peripheral artery disease (PAD), adverse events such as high restenosis rate or premature death after EVT remain major clinical problems in patients on hemodialysis (HD). On the other hand, malnutrition and chronic inflammation status are frequently observed, and linked to poor cardiovascular outcome in such population. We evaluated the possible prognostic values of serum albumin and C-reactive protein (CRP) levels on clinical outcomes after EVT in patients on HD. Methods: A total of 450 HD patients successfully undergoing EVT for PAD were enrolled and were followed-up for up to 8 years. Serum albumin and CRP levels were measured prior to EVT. They were divided into tertiles according to serum albumin and CRP levels; the lowest tertile (T1), the middle tertile (T2) and the highest tertile (T3), respectively. We analyzed the incidence of major adverse cardiovascular events (MACE) as a composite endpoint including target lesion revascularization (TLR), amputation and all-cause death. Results: During follow-up period (mean 36±31months), 206 MACE (46%) including 67 TLRs, 45 amputations and 94 deaths occurred. Event-free survival rate from MACE for 8 years was 23.1%, 25.9%, and 50.0% in T1, T2 and T3 of albumin (p&lt;0.0001), and 41.2%, 36.3% and 18.9% in T1, T2 and T3 of CRP (p=0.0004), respectively. After adjustment, lower albumin (HR 2.00, 95%CI 1.29-3.10, p=0.0071 for T1 vs. T3) and elevated CRP (HR 1.93, 95%CI 1.29-2.90, p=0.0061 for T3 vs. T1) were independent predictors for MACE, respectively. Furthermore, in the combined setting of albumin and CRP, the risk of MACE was 5.22-fold (95%CI 2.34-11.64, p=0.0011) higher in the T1 of albumin with T3 of CRP compared to the T3 of albumin with T1 of CRP even after adjustment (Figure). Conclusions: Lower albumin and elevated CRP levels could strongly predict MACE after EVT in patients on HD. However, the combination of these variables is more markedly related to increased MACE than either variable alone.
Abstract 1357: A Novel Prostaglandin E2 Receptor EP4-Selective Agonist Attenuates Inflammatory Activation of Macrophages in vitro and in vivo
Authors: Kiyoshi Takayama, Yasuo Asano, Mayumi Ueki, Akiko Takahashi, Yoshihisa Toda, Takayuki Seki, Teisuke Takahashi, Michihito Onishi, Naoya Ono, Makoto Yagi, Astushi Ichikawa
Journal: Circulation (2006)

Background: Prostaglandin E2 ( PGE2 ) exerts its biological functions mainly via four G protein-coupled seven transmembrane receptors ( EP1– 4 ). Several lines of evidence suggest that the EP4 rece...
Abstract 4495: No Per-Procedural Mortality during Percutaneous Transluminal Septal Myocardial Ablation (ptsma) in Patients with Hypertrophic Obstructive Cardiomyopathy (hocm) and No Excess Mortality at Long Term Follow Up
Authors: Morten K, Ole Havndrup, Steffen Helqvist, Henning Kelbaek, Erik Joergensen, Christian Hassager, Lars Kober, Henning Bundgaard
Journal: Circulation (2008)
Response of Variant Hereditary Angioedema Phenotypes to Danazol Therapy
Authors: James E. Gadek, Stephen W. Hosea, Jeffrey A. Gelfand, Michael M. Frank
Journal: Journal of Clinical Investigation (1979)

Hereditary angioedema (HAE), an auto-somal dominant disorder characterized by attacks of episodic edema is associated with decreased functional levels of the C1 esterase inhibitor. Approximately 85% of patients have lowered antigen levels of a normal inhibitor protein. 15% of patients have normal or elevated antigenic levels of functionless protein. We have examined the response to danazol therapy of patients with the variant HAE phenotypes possessing the abnormal protein in an effort to determine if these patients possess a normal structural C1 inhibitor allele. Four patients with a variant HAE phenotype were treated successfully with danazol. In two patients, distinguished by the presence of a functionless, albumin-bound, C1 inhibitor (phenotype 2), phenotypic analysis of the danazol response by bidirectional immunoelectrophoresis revealed the appearance of the normal C1 inhibitor gene product during danazol therapy. This relatively cathodal C1 inhibitor peak appears in conjunction with the development of nearly normal functional activity. All of the functional C1 inhibitory activity which appeared in the phenotype 2 treatment serum was associated with the electrophoretically normal inhibitor. This normal protein could be separated from the functionless inhibitor protein by immunoadsorption and molecular sieve chromatography. Danazol therapy of the two patients with an electrophoretically normal, functionless C1 inhibitor (phenotype 3) also resulted in a clinical remission associated with development of a significant increment in functional serum C1 inhibitory activity and C1 inhibitor protein. These findings demonstrate that these two HAE phenotypic variants are heterozygous for the normal serum C1 inhibitor, a finding which was not apparent before phenotypic analysis of this serum during danazol therapy. These data provide strong evidence for a basic similarity between the common form of HAE and its phenotypic variants. They also suggest that a structural gene lesion may result in the abnormalities of serum C1 inhibitor function and disease expression in all three of these HAE phenotypes.
Abstract 10729: Freshly Isolated Fibroblasts From Normal Hearts Affect Cardiomyocyte Structure and Function Via Paracrine Communication, and These Effects are Altered in Fibroblasts From Pressure Overloaded Hearts
Authors: James E Cartledge, Meron Tesfom, Priyanthi Dias, Michael Ibrahim, Magdi H Yacoub, Patrizia Camelliti, Cesare M Terracciano
Journal: Circulation (2012)

α-smooth muscle actin (α-SMA)-positive cardiac myofibroblasts (CMF) release paracrine mediators that affect cardiomyocyte (CM) structure and function. However, studies have used cardiac fibroblasts (CF) isolated from healthy hearts and activated to CMFs by culture. Whether freshly isolated SMA-negative CFs from healthy hearts affect CM structure and function and whether these effects are altered in CFs after pathological stimulation is unknown. We studied rat LV CFs freshly isolated from normal hearts (sham operated - S CF) and from hearts undergoing thoracic aortic constriction for 10 weeks (T CF). Within 24 hours of isolation CFs were cultured on Transwells above isolated adult rat LV myocytes to allow only paracrine communication (S CF+CM or T CF+CM). CMs co-cultured with other CMs were used as control (CM+CM). After 20 hours we measured adult CM size, contractility and Ca2+ handling. CM volume, assessed by Di-8-ANEPPS staining, was increased in S CF+CM and T CF+CM vs. CM+CM (µm3: CM+CM 40207±2171 (n=46), S CF+CM 47080±1895 (n=33), T CF+CM 48014±2049 (n=58); p
Abstract 3797: Coronary Septal Collaterals as an Access for the Retrograde Approach in the Percutaneous Treatment of Coronary Chronic Total Occlusions
Authors: Jean-Francois Surmely, Osamu Katoh, Etsuo Tsuchikane, Kenya Nasu, Takahiko Suzuki
Journal: Circulation (2006)

Background: Despite improvements in percutaneous techniques and materials, CTO recanalization success rate is still suboptimal. The retrograde approach allows to significantly increase this success rate. However, its application via a bypass graft or epicardial collateral can potentially result in severe complications. A safer retrograde access is therefore desired. Hypothesis: To investigate the feasibility and safety of the percutaneous dilatation of coronary septal collaterals to allow their uses as an access for retrograde approach to percutaneous coronary intervention (PCI) of CTOs.  Methods: After a failed antegrade CTO recanalization attempt, a retrograde approach via septal collaterals was tried in 21 patients (19 males, 2 females). The septal collateral was accessed via the contra-lateral patent coronary artery and was crossed with a hydrophilic floppy wire. After successful wire crossing of the septal collateral, sequential low pressure dilatation was performed with a 1.25 or 1.5 mm balloon, in order to allow the delivery of a balloon catheter up to the distal CTO site. Pre- and post-dilatation example with OCT images shown in figure.  Results: Successful wire crossing and balloon dilatation of septal collaterals was achieved in 19 cases and in 17 cases respectively. Post dilatation septal collateral diameter increased significantly reaching a mean diameter of 1.46 ± 0.38 mm. Retrograde CTO recanalization was successfully performed in 71% of the cases. No major complications occurred.  Conclusions: Coronary septal collaterals can be used as an access for the retrograde approach in the percutaneous treatment of CTOs.
Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study.
Authors: Rochelle E. Curtis, Lois B. Travis, Philip A. Rowlings, Gérard Socié, Douglas W. Kingma, Peter M. Banks, Elaine S. Jaffe, George E. Sale, Mary M. Horowitz, Robert P. Witherspoon, Donna A. Shriner, Daniel J. Weisdorf, Hans Jochem Kolb, Keith M. Sullivan, Kathleen A. Sobocinski, Robert Peter Gale, Robert N. Hoover, Joseph F. Fraumeni, H. Joachim Deeg
Journal: Blood (1999)
Abstract 3818: Combined Echocardiographic Left Ventricular Hypertrophy and Quantitative Electrocardiographic Strain Pattern Predict New-Onset Heart Failure: The Strong Heart Study
Authors: Peter M Okin, Mary J Roman, Elisa T Lee, James M Galloway, Lyle G Best, Marie Russell, Richard B Devereux
Journal: Circulation (2006)

Background: Echocardiographic left ventricular hypertrophy (Echo-LVH) and quantitative measures of ST depression on the ECG (ECG-STD) in the lateral precordial leads have each been demonstrated to ...
Prognostic Significance Of NPM1 mutations In The Absence Of FLT3-ITD in Older Patients With AML: A SWOG Report
Authors: Fabiana Ostronoff, Megan Othus, Soheil Meshinchi, John E. Godwin, Kenneth J. Kopecky, Alan List, Vivian G. Oehler, Stephen Petersdorf, Era L. Pogosova-Agadjanyan, Jerald Radich, Cheryl L. Willman, Frederick R. Appelbaum, Derek L. Stirewalt
Journal: Blood (2013)
DIPNET – establishment of a dedicated surveillance network for diphtheria in Europe
Authors: S Neal, A Efstratiou, None on behalf of DIPNET
Journal: Eurosurveillance (2007)

The ninth international meeting of the European Laboratory Working Group on Diphtheria (ELWGD) and the first annual meeting of the Diphtheria Surveillance Network (DIPNET) was held in Vouliagmeni, Greece, in November 2006. The recognition of DIPNET as an established Dedicated Surveillance Network (DSN) by the European Commission (EC) was announced, with the specific objective "to establish a Pan-European network of expertise for the prevention of diphtheria and other related infections". At the meeting, DIPNET participants from the European Union (EU) Member States and associated countries as well as collaborators from countries beyond EU presented the current situation concerning the clinical, epidemiological and microbiological aspects of diphtheria and related infections. Issues highlighted included the need for improving surveillance systems, supporting laboratory diagnostics globally, and undertaking screening and seroepidemiological studies to sustain diphtheria control in the WHO European Region and beyond.
Abstract 2247: Patent Foramen Ovale And Marfan Syndrome: A New Association
Authors: Violeta Sanchez, Teresa Mombiela, Alberto Forteza, Juan F Delgado, Federico Lombera, Sagrario Fernandez, Carlos Saenz de la Calzada, Jose M Cortina
Journal: Circulation (2008)

Marfan syndrome (MS) is the most common inherited disorder of connective tissue which affects multiple organ systems. Cardiovascular involvement in MS includes dilatation or dissection of the aorti...
Cheese lovers should not be condemned to a pasteurised and tasteless product
Authors: E. Rose
Journal: BMJ (1996)

products....Although Stalin had a sophisticated propaganda machine for its time, the tobacco industry is using the most advanced technology available to produce a 21st-century propaganda effort.Stalin's methods were perceived as cold and calculating, but those of the tobacco industry are smooth and subtle.The marketing plans are prospective, with the result of pervasively infiltrating all facets of Russian life."2I find Hurt's analogy entirely apt, and I urge Cambridge most earnestly to deny BAT an honour which will lower the esteem in which Cambridge is held throughout the world.
Steroid concentrations in patients with atopic dermatitis: reduced plasma dehydroepiandrosterone sulfate and increased cortisone levels
Authors: J. Mihály, D. Sonntag, G. Krebiehl, A. Szegedi, D. Töröcsik, R. Rühl
Journal: British Journal of Dermatology (2014)

DEAR EDITOR, atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease, which is characterized by a disrupted epidermal barrier function present
Comparative Study of Portal Hypertensive Gastropathy in Schistosomiasis and Hepatic Cirrhosis
Authors: D. Marques Chaves, P. Sakai, M. Mucenic, K. Iriya, Y. Iriya, S. Ishioka
Journal: Endoscopy (2002)

Background and Study Aims: Portal hypertensive gastropathy (PHG) is a common finding in chronic liver disease, but it has not been evaluated in hepatosplenic schistosomiasis, a significant cause of noncirrhotic portal hypertension worldwide. Our study was aimed at comparing cirrhosis with hepatosplenic schistosomiasis with regard to the endoscopic and histological findings of PHG. Patients and Methods: We included 43 patients with a history of upper digestive hemorrhage, 22 with cirrhosis and 21 with schistosomiasis, without previous surgical or endoscopic treatment. Upper digestive endoscopies with macrobiopsies of the gastric body were prospectively performed in all cases.
Abstract 281: Does Chest Compression-Only CPR Provide Meaningful Gas Exchange in Humans?
Authors: Jason Roosa, Brian Kitamura, Kyle McCarty, Rianne Page, Pedro Roque, Annemarie Silver, Daniel Spaite, Uwe Stolz, Tyler Vadeboncoeur, Bentley Bobrow
Journal: Circulation (2012)

Background: During CPR in animals, chest compressions (CC) may produce passive volumes large enough to provide adequate ventilation. In humans, this mechanism may explain why continuous CCs have been associated with improved survival. We quantified the volume of passive ventilation during emergency department (ED) CCs to determine if compression-only CPR (COCPR) provides clinically significant gas exchange during resuscitation. Methods: In an urban ED, continuous flow and volume of air exhaled through an endotracheal tube were measured during the CC phase of manual CPR (between ventilations) with NICO monitors (Philip/Respironics) and recorded using LabView (National Instruments). Gas exchange with CC was quantified using Matlab (Mathworks) as the area under the flow curve (figure). CC quality was measured using accelerometer-based technology (R Series, ZOLL Medical). Results: Eight patients (6 male) aged 37-83 yrs [median age 51 yr (IQR 43-56)] who suffered out-of-hospital cardiac arrest (CA) and were transported and treated with CC in the ED were included. A total of 548 CCs [median depth 1.89 in (IQR=1.66, 2.29), median rate 128 CC/min (IQR=122-134) were analyzed over 30 min of CPR. Median tidal volume per CC was 17.3 mL (IQR=5.9-22.4). This was considerably less than measured dead space in all patients (median 118mL, IQR=93-143), regardless of CC depth. The figure illustrates a typical tracing in which ventilation volume dwarfs any passive ventilation occurring with CC. Conclusion: Late in CA, passive ventilation occurring during CCs appears to produce considerably less gas exchange than calculated dead space. The effectiveness of passive ventilation during early stages of CPR, when chest and lung compliance are greater, remains unknown. However, these findings suggest that the benefits of COCPR strategies may be related to reliably higher CC fraction and/or prevention of the negative effects of hyperventilation rather than from any passive ventilation.
Video clip is worth 1000 words
Authors: William A M Cutting
Journal: BMJ (2007)

Identifying a seriously ill feverish child, as opposed to one who is miserable and irritable because he or she is uncomfortable with a simple condition, requires care and experience. Harnden reminds us that there is no simplistic formula; a full assessment is needed in which a careful examination is more important than the history, which is why “telephone triage” can be dangerous. A further review is important as the condition of children evolve and change …
Abstract 15095: Differential Prognostic Implication of a Point-of-Care Platelet Function Test in Patients with Acute Coronary Syndrome Versus Stable Angina and Who Undergoing Percutaneous Coronary Intervention
Authors: Duk-Woo Park, Yong-Giun Kim, Gyung-Min Park, Ki Won Hwang, Chang Hee Kwon, Jeong Yoon Jang, Suk-Won Choi, Hae-Geun Song, Jung-Min Ahn, Won-Jang Kim, Jong-Young Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Circulation (2011)

BACKGROUND High platelet reactivity during clopidogrel therapy has been linked to cardiovascular events after percutaneous coronary intervention (PCI). However, whether or not prognostic implicatio...
Novel Approaches for Preventing or Limiting Events (Naples) II Trial
Authors: Carlo Briguori, Gabriella Visconti, Amelia Focaccio, Bruno Golia, Alaide Chieffo, Alfredo Castelli, Marco Mussardo, Matteo Montorfano, Bruno Ricciardelli, Antonio Colombo
Journal: Journal of the American College of Cardiology (2009)
Abstract MP27: Cardiovascular Biomarkers and MRI-defined Small Vessel Disease of the Brain in the Atherosclerosis Risk in Communities (ARIC) Study
Authors: Razvan T Dadu, Myriam Fornage, Salim S Virani, Vijay Nambi, Ron C Hoogeveen, Eric Boerwinkle, Alvaro Alonso, Rebecca F Gottesman, Thomas H Mosley, Christie M Ballantyne
Journal: Circulation (2013)

Background: Cerebrovascular and cardiovascular disease share common risk factors. Thus, biomarkers associated with subclinical cardiac injury may also be associated with silent cerebral injury. We hypothesized that levels of N-terminal brain natriuretic peptide (NT-proBNP) and cardiac troponin T measured with a highly sensitive assay (hs-cTnT) are associated with silent brain infarcts (BI) and white matter lesions (WML) on magnetic resonance imaging (MRI) in the Atherosclerosis Risk In Communities (ARIC) study. Methods: Brain MRI was performed at ARIC visit 3 (1993-1995) on 1920 participants. NT-proBNP and hs-cTnT were measured in all individuals at ARIC visit 4 (1996-1998). A subset (N=1112) of those individuals who had the initial MRI at Visit 3, had a follow up MRI in 2004-2006. We analyzed the association of NT-proBNP and hs-cTnT with the presence of MRI defined BI and WML on the initial MRI and on the follow-up MRI in participants without coronary heart disease and stroke. BI was defined as an area of abnormal signal intensity in a vascular distribution, ≥ 3 millimeters in size, and without mass effect. WML were estimated as the total volume of periventricular and subcortical white matter-signal abnormality. Results: In the adjusted model, individuals in the highest NT-proBNP quartile had significantly more BI and WML on the baseline MRI and more incident BI and WML progression on the follow up MRI when compared to the lowest quartile (Table). In the same model, individuals in the highest hs-cTnT category had significantly more BI and WML on the initial MRI and more WML progression on the follow up MRI when compared to the lowest category. Incident BIs were significantly more common in the 0.009 to ≤0.013 μg/L troponin category but not in the highest one, when compared to the lowest category (Table). Conclusion: NT-proBNP and hs-cTnT are independently associated with silent MRI-defined BI and WML suggesting that biomarkers for subclinical cardiac injury may also be useful to identify individuals with subclinical cerebral injury.