tbuckley/cabot-search huggingface dataset:
CULLEN'S SIGN IN RUPTURED ECTOPIC PREGNANCY
Authors: A M LINKLETTER, F C MOORE
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An anaesthetist's view
Authors: J. N Lunn
Journal: BMJ (1995)

So far as I can ascertain the report by John Mitchell is the only account of this case.1 The implications of the case are many and, based solely on the information given, my commentary can deal with only a few.

Hearings before the professional conduct committee of the General Medical Council are normally held in public. The identities of the people concerned in this case are not given in Mitchell's report, though they are on the public record.

The strength of an expert's testimony in law is related to that person's professional position. In this hearing two groups of one or more professional peers on each side (that is, equals and registered medical practitioners with the GMC) gave their opinions. The professional conduct committee, probably with no anaesthetists of comparable standing, passed a verdict of serious professional misconduct. It should be noted that experts on both sides apparently considered that the respondent (a consultant anaesthetist) practised modern and appropriate anaesthesia. This opinion about competence might be thought to conflict with a finding of serious professional misconduct. A bystander might find it difficult to understand …
Abstract 17786: Impact of High Admission Blood Pressure Without History of Hypertension on Clinical Outcomes of Patients With Acute Myocardial Infarction
Authors: Jae Yeong Cho, Myung Ho Jeong, Youngkeun Ahn, Hae Chang Jeong, Su Young Jang, Sung Soo Kim, Shi Hyun Rhew, Young Wook Jeong, Ki Hong Lee, Keun-Ho Park, Doo Sun Sim, Kye Hun Kim, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Jeong Gwan Cho, Jong Chun Park, Young Jo Kim, Chong Jin Kim, Myeong Chan Cho, Kyoo Rok Han, Hyo Soo Kim
Journal: Circulation (2013)

OBJECTIVES: We aimed to investigate how admission BP status impact on clinical outcomes after percutaneous coronary intervention (PCI) in Korean acute myocardial infarction (AMI) patients. BACKGROU...
Abstract 18084: Systematic Analysis of Gene Expression Differences Between Left and Right Atria in Different Mouse Strains and in Human Atrial Tissue
Authors: Ilaria Piccini, Peter C Kahr, Larissa Fabritz, Boris Greber, Hans Schöler, Hans H Scheld, Andreas Hoffmeier, Nigel A Brown, Paulus Kirchhof
Journal: Circulation (2011)

Background: Normal development of the atria requires left-right differentiation during embryonic development. Reduced expression of Pitx2c (Paired-like homeodomain transcription factor2, isoform c), a key regulator of left-right asymmetry, has recently been linked to atrial fibrillation. To characterize differences between left and right atrium in adult hearts, we systematically studied the molecular composition of left and right atrial tissue in adult murine and human atria. Methods: We compared left and right atrial gene expression in healthy, adult mice of different strains (MF1, 3 months old; MF1, 12 months old; Swiss Agouti, 12 months old) by employing whole genome array analyses on freshly frozen atrial tissue. Selected genes with enriched expression in right or left atrium were validated by RT-qPCR in further animals, and by RT-qPCR and Western blot in shock-frozen left and right atrial appendages of patients undergoing open heart surgery. Results: We identified 77 genes with preferential expression in one atrium that were common in all strains and age groups analysed. Independent of strain and age, Pitx2c was the gene with the highest enrichment in left atrium, while Bmp10 (Bone morphogenetic protein 10) showed enrichment in right atrium, consistent with prior reports. Nine selected genes, including Pitx2c, were validated by RT-qPCR in murine tissue, and five orthologous genes in human tissue. Western blot showed a 2-fold left-right ratio in PITX2c protein in adult human atria. Several of the genes and gene groups enriched in left atria have a reasonable biological role for the prevention of atrial pathology including atrial fibrillation, membrane electrophysiology, metabolic cellular function, and regulation of inflammatory cells. Comparison of the array data sets with published array analyses in heterozygous pitx2+/- atria suggested that approximately half of the genes with left-sided enrichment are regulated by Pitx2c. Conclusions: Our study reveals systematic differences between left and right atrial gene expression during adulthood and supports the hypothesis that Pitx2c has a functional role in maintaining “leftness” in the atrium in adult mice and humans.
Ebola in the United States — Public Reactions and Implications
Authors: Gillian K. SteelFisher, Robert J. Blendon, Narayani Lasala-Blanco
Journal: New England Journal of Medicine (2015)

Despite the minimal presence of Ebola in the United States, the U.S. public expressed great concern about their risk. Such disproportionate concern, based partly on misperceptions and mistrust, may distract attention from more critical health priorities.
Abstract 3615: Prognostic Value of Plasma Myeloperoxidase Levels Across the Spectrum of Systolic and Diastolic Dysfunction in Patients with Chronic Systolic Heart Failure
Authors: W. H. Wilson Tang, Wilson Tong, Richard W Troughton, Maureen G Martin, Allen G Borowski, Susan E Jasper, Stanley L Hazen, Allan L Klein
Journal: Circulation (2006)
Abstract 8543: Ectopic Fat Mobilization Following a Bariatric Surgery-Induced Weight Loss; Association with Insulin Resistance
Authors: Audrey Auclair, Julie Martin, Marjorie Bastien, Nadine Bonneville, Frédéric-Simon Hould, Simon Marceau, Paul Poirier
Journal: Circulation (2011)

Severe obesity is associated with increased cardiovascular morbidity and mortality and is increasing in prevalence. The purpose of the study was to measure the impact of weight loss and changes in insulin resistance following biliopancreatic diversion with duodenal switch (BPD-DS) procedure on adiposity and skeletal muscle. Anthropometric measures, mid-thigh computed tomography (CT) and fasting plasma glucose and insulin were measured at baseline, at 6 and 12 months in severely obese subjects who underwent BPD-DS (n=43) and in a severely obese control group (n=24). At baseline, the two groups were similar for age, sex, weight (128.3±23.3 vs. 117.6±19.1 kg; p=0.059, BPD-DS vs. control respectively) and mid-thigh CT composition but not for body mass index (BMI) (47.6±5.9 vs. 43.5±4.8 kg/m2; p=0.004). At 6 months, in the BPD-DS group, there were a significant decrement in weight (-26.7±7.4%), BMI (-26.7±5.6%), as well as in mid-thigh CT composition: total adipose tissue (-34.7±10.5%), deep adipose tissue (-36.1±15.4%), subcutaneous adipose tissue (-34.7±10.5%), total skeletal muscle (-19.2±8.8%), fat infiltrated muscle (-54.4±29.4%) and non-fat infiltrated muscle (-17.7±11.4%); all p&lt;0.001. Between month 6 and 12, in the BDP-DS group, weight, BMI, total, deep and subcutaneous adipose tissue decrease significantly but to a lesser degree compared to the first 6 month; all p≤0.001. There was no change regarding total skeletal muscle, but a significant increment in non-fat infiltrated muscle (5.3±7.8%) and decrement in fat infiltrated muscle (-11.8±10.8%); all p≤0.001. A decreased in insulin resistance at 6 and 12 months was associated with a reduction of thigh deep adipose tissue (r=0.469, r=0.692, 6 and 12 months respectively) and fat infiltrated muscle (r=0.469, r=0.526); all p≤0.001. There were no changes, in all these parameters in the control group. BPD-DS surgery-induced weight loss had major impact on muscle and fat mass. Mobilization of thigh ectopic fat; thigh deep adipose tissue and fat-infiltrated muscle, may be one mechanism that improves insulin resistance. Muscle regain at 12 months suggests that BPD-DS exerts a physiologic effect beyond that of nutrient restriction on the regulation of energy metabolism.
Exercise Training and Implantable Cardioverter-Defibrillator Shocks in Patients With Heart Failure
Authors: Jonathan P. Piccini, Anne S. Hellkamp, David J. Whellan, Stephen J. Ellis, Steven J. Keteyian, William E. Kraus, Adrian F. Hernandez, James P. Daubert, Ileana L. Piña, Christopher M. O’Connor
Journal: JACC Heart Failure (2013)
Abstract 151: H2O2 Operates As An Endothelium-derived Hyperpolarizing Factor By Directly Activating Protein Kinase G (PKG) I{alpha} Independently Of cGMP Via Disulfide Formation
Authors: Joseph R Burgoyne, Melanie Madhani, Friederike Cuello, Rebecca L Charles, Jonathan P Brennan, Ewald Schroder, Philip Eaton
Journal: Circulation (2007)

H2O2 (5min, 100μM) perfusion of isolated rat hearts promoted interprotein disulfide formation (from 36% to 86%, P<0.01, observed on immunoblots) in PKG1α. Hearts showed a time and dose dependent co...
Molecular Characterization Of The Anti-Leukemic Effects Of Single Agent Eltrombopag
Authors: Uwe Platzbecker, Katja Sockel, Claudia Schönefeldt, Daniel Nowak, Susann Helas, Christoph Röllig, Maximilian Mossner, Johann-Christoph Jann, Gerhard Ehninger, Wolf-Karsten Hofmann, Martin Bornhäuser, Christian Thiede, Martin Wermke
Journal: Blood (2013)
Abstract 14675: Efficacy of Intramyocardial Injection of Bone Marrow Cells in Chronic Myocardial Disease is Influenced by Anatomical Location of Injection Site
Authors: Sander Rodrigo, Jan van Ramshorst, Saskia L Beeres, Petra Dibbets-Schneider, Albert de Roos, Willem E Fibbe, Jaap J Zwaginga, Ernst E van der Wall, Martin J Schalij, Jeroen J Bax, Douwe E Atsma
Journal: Circulation (2011)

Background: Intramyocardial injection of bone marrow cells (BMC) improves myocardial perfusion in patients with chronic myocardial disease. Efficacy of BMC treatment may be influenced by the anatom...
Abstract 1999: Percutaneous Coronary Intervention with Off-site Cardiac Surgery Backup for Acute Myocardial Infarction as a Strategy to Reduce Door-to-Balloon Time.
Authors: Victor A Umans, Hans O Peels, Hans de Swart, Raymond Hautvast
Journal: Circulation (2007)

We sought to determine whether primary percutaneous coronary intervention (PCI) for patients admitted with an acute ST-segment elevation myocardial infarction (STEMI) can be performed more rapidly and with comparable outcomes in a community hospital vs. a tertiary center with cardiac surgery. We started the first PCI with off-site surgery program in the Netherlands in 2002 and report the results of 639 consecutive pts. In the safety phase, 199 patients presenting with STEMI were randomly assigned to treatment at our off-site center vs a more distant cardiac surgery center. In the confirmation phase, 440 consecutive patients were treated in the off-site hospital. Safety and efficacy endpoints were the rate of angiographically successful PCI procedure (diameter stenosis &lt;50% and TIMI 3 flow) in the absence of major adverse cardiac and cerebrovascular events (MACCE) at 30 days. The randomization phase showed a significant decrease of 37 minutes in door-to-balloon time (p&lt;0.001) with comparable procedural and clinical success (91% TIMI-3 flow in both groups). In the confirmation phase, the 30-day MACCE-free rate was 95%. None of the 639 patients in the study required emergency surgery for failed primary PCI. Time to treatment with primary PCI can be significantly reduced when treating patients in a community hospital setting with off-site cardiac surgery backup as compared with transport for PCI to a referral center with on-site surgery. PCI at hospitals with off-site cardiac surgery backup can be considered as one of the needed strategies to improve access to primary PCI for a larger segment of the population basis, and can be delivered with a very favorable safety profile.
Abstract 12585: Gender and Left Atrial Ablation for Atrial Fibríllation: Outcome Data from the German Ablation Registry
Authors: Helge U Simon, Anil M Sinha, Martin Horack, Jochen Senges, Thorsten Lewalter, Dietrich Andresen, Ellen Hoffmann, Stefan Spitzer, Stephan Willems, Karl-Heinz Kuck, Jürgen Tebbenjohanns, Burghard Schumacher, Johannes Brachmann
Journal: Circulation (2010)

Women tend to be underrepresented in many clinical trials and often seem to be referred to undergo invasive procedures less frequently. The German Ablation Registry (GAR) is a designed as a multi-center prospective registry for electrophysiologic ablation procedures. It provides patient- and procedural characteristics and short- and long- term outcome data from 55 ablation centers. From March 2007 until May 2010, 6066 consecutive patients undergoing left atrial ablation for atrial fibrillation (AF) were included: 1970 (32.5%) f (female), 4096, 67.5% m (male) patients. This is the first report about preliminary outcome data. Results: DM (f: 9.4%, m: 7.8%, p<0.05), hypertension (f: 66.1%, m: 58.1%, p<0.01) and valvular heart disease (f: 9.8%, m: 8.0%, p<0.05) were more common in female patients whereas CAD (f: 13.0%, m: 21.3%, p<0.05) and cardiomyopathies (f: 2.7%, m: 5.0%, p<0.0001) were more frequent in males. Women were older (f: 66y [59–70y], m: 61y [53–68y], p<0.001) and had more paroxysmal AF (f: 67.1...
NSCLCs harboring EGFR kinase domain mutations are sensitive to proteasome inhibition
Authors: Takeshi Shimamura, Susumu Kobayashi, Danan Li, April Lowell, Christa Borgman, Kwok Wong, Balazs Halmos, Daniel Tenen, Geoffrey Shapiro
Journal: Cancer Research (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

3261 

The ubiquitin-proteasome pathway regulates the intracellular concentration of key proteins including oncogenic kinases. Proteasome inhibition in NSCLC has been tested preclinically, but previous studies have not identified a subset most likely to benefit. Here we report that NSCLC cell lines harboring EGFR kinase domain mutations are routinely sensitive to proteasome inhibition. Activating mutations in the kinase domain of EGFR are most commonly exon 19 deletions and substitutions for L858 in exon 21, and confer sensitivity to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib. Over time, resistance universally emerges,associated with a second somatic T790M mutation in approximately 50% of cases. Currently, irreversible EGFR inhibitors are being tested in erlotinib-resistant NSCLCs, with limited efficacy reported in preliminary studies. We propose proteasome inhibition as a novel strategy for NSCLCs resistant to EGFR inhibitors. We have challenged two groups of NSCLC cell lines with bortezomib: one with EGFR mutation and the other with wild-type (WT) EGFR. Annexin V apoptosis assay revealed that IC50s for mutant EGFR NSCLC cells are routinely below 50nM, whereas IC50s for the majority of WT cell lines are above 50nM. Identical results were obtained with other proteasome inhibitors, including MG262 and MG132. In NCI-H1975 cell (EGFR L858R-T790M), 25nM bortezomib treatment caused caspase 3 induction at 16hrs while the induction was not in evident in NCI-H460 cell (EGFR-WT). The induction of apoptosis was partially reversed with a pan-caspase inhibitor Z-VAD-fmk. Proteasome inhibition caused an initial increase in the expression of EGFR, followed by depletion of the protein by 24 hours. Real-time qRT-PCR indicated that EGFR depletion does not occur at the transcription level. The treatment of H1975 or HCC827 (EGFR del) cells with 100nM bortezomib resulted in the induction of Grp78 and Hsp70 at 8 hrs, suggesting the initiation of ER stress. Phosphorylation of eIF2a was evident at 16hrs, which coincided with EGFR depletion, caspase 3 activation, and PARP cleavage. Pretreatment of HCC827 and H1975 cells with a low dose of cyclohexamide reversed the effects of bortezomib. Bortezomib also caused tumor regression in an inducible bitransgenic murine model of adenocarcinoma driven by EGFR harboring compound L858R/T790M mutation. Moreover, HCC827 and H1975 cells were sensitive to Tunicamycin or 2-deoxyglucose, compounds that induce ER stress with a depletion of EGFR. In summary, proteasome inhibition is effective against NSCLCs with EGFR mutations. The mechanism connecting ER stress to apoptosis is under active investigation.
Abstract 16331: Netrin-1 Abrogates Ischemia Reperfusion Induced Cardiac Mitochondrial Dysfunction via Attenuation Of NOX4 And NOS Uncoupling
Authors: Kin L Siu, Jun Zhang, Christopher Lotz, Peipei Ping, Hua L Cai
Journal: Circulation (2011)

Oxidative stress has been shown to mediate cardiac ischemia reperfusion (I/R) injury. We have previously characterized a novel pathway by which netrin-1 induces cardioprotection at least partially ...
Exacerbation of Psychosis by Tricyclic Antidepressants in Delusional Depression
Authors: J. Craig Nelson, Malcolm B. Bowers, Donald R. Sweeney
Journal: American Journal of Psychiatry (1979)

The authors describe three patients with delusional unipolar depression whose delusional thinking worsened markedly following administration of tricyclic antidepressant drugs. The patients had met Research Diagnostic Criteria for major depressive episode and had no evidence of schizophrenia or mania. Since tricyclic antidepressants are known to exacerbate psychosis in schizophrenic patients, it is sometimes suggested that the exacerbation of psychotic thinking in depressed patients indicates schizophrenia. The authors suggest that such an exacerbation does not in itself indicate schizophrenia but may occur in patients with an affective disorder who are prone to depressive delusions. The authors discuss the use of antipsychotic medication in this patient group and present a neurochemical hypothesis to explain the interaction of the drug with the illness, which results in exacerbation of psychotic thinking.
Abstract 11179: Development of a Novel Hybrid Device with Rechargeable Drug-Eluting Capability for Minimally Invasive Treatment of Aortic Aneurysms
Authors: Koichi Yoshimura, Hiroki Aoki, Hiromori Tsutsumi, Shun'ichi Kuroda, Yasuhiro Ikeda, Kimikazu Hamano
Journal: Circulation (2011)

Ongoing aortic wall degeneration and subsequent failure of aneurysm exclusion is the major concern after the endovascular aneurysm repair (EVAR). The aortic wall-targeted drug therapy to inhibit the wall degeneration would provide an ideal solution for this concern. Here, we report a novel device, the rechargeable drug delivery system (RDDS), which is capable of charging, recharging and releasing drugs in vivo for the treatment of aortic aneurysms. We have developed basic technologies for RDDS by using neutravidin-biotin interaction. We created the targeted graft, which is a biotinylated polyester graft bound to neutravidin. We also created the target recognition nanocarrier by conjugating drug-containing liposomes and biotinylated bio-nanocapsules (BNCs). We succeeded in incorporating suitable drugs for aneurysm treatment, such as HMG-CoA reductase inhibitors (statins) or a JNK inhibitor, into the BNC-liposome complex. We demonstrated that the target recognition nanocarriers can bind to the target molecule-labeled graft both in vitro experiments and in the blood vessels of live animals. Moreover, we examined the local drug delivery from the graft to the aortic wall in mouse. For this experiment, we placed the graft bound to the statin-containing nanocarriers just close by mouse abdominal aorta, which was stimulated with 0.5M CaCl2. While treatment with calcium caused high expression of MMP-9 in the aortic tissue, the statin-containing graft significantly reduced the MMP-9 expression, indicating the successful local drug delivery from the graft to the aortic wall in vivo. Thus, we propose that RDDS is a possible adjuvant therapy to improve the long-term outcome of EVAR.
Abstract 11437: Circulating Anti-Elastin Antibody and Arterial Disease Characteristics: Association With Arterial Stiffness and Atherosclerosis
Authors: Seung-Hyun Lee, Kihyuk Shin, Sungha Park, Seok-Min Kang, Seung-Hyo Lee, Sang-Hak Lee
Journal: Circulation (2014)

Objectives: Elastin is a major structural protein of arteries and elastin derived peptide is known to be related to arterial change. We previously reported a novel assay for anti-aortic elastin antibody, but its clinical implication has not been clearly shown. The aim of this study was to check if anti-aortic elastin antibody titers may reflect the risk of coronary artery disease (CAD) or its detail characteristics. Methods: This study included 174 CAD patients and 171 age-, sex-matched control subjects. In all subjects, anti-aortic elastin antibody titer was quantified by ELISA. Parameters of arterial stiffness including augmentation index (AI) and heart to femoral pulse wave velocity (hfPWV) were measured non-invasively. In patients with CAD, clinical and angiographic characteristics were evaluated. Associations between anti-aortic elastin and vascular characteristics were identified by linear regression analysis. Results: Median blood level of anti-aortic elastin was significantly lower in the CAD group than that of the control group (197 a.u. vs. 63 a.u., p&lt;0.001). Levels of anti-aortic elastin were significantly lower in males, subjects with hypertension, diabetes mellitus, hyperlipidemia, or hfPWV (Figure). However, the levels were not dependent of atherothrombotic events or angiographic severity of CAD (Figure). In multivariate analysis, male (β=-0.38, p&lt;0.001), diabetes mellitus (β=-0.62, p&lt;0.001), hyperlipidemia (β=-0.29, p&lt;0.001), and AI (β=-0.006, p=0.02) were finally identified as determinants for anti-aortic elastin levels (Table). Conclusions: Taken together, lower levels of anti-aortic elastin are related to CAD. The association between antibody titer and CAD is linked to arterial stiffness rather than advancement of atherosclerosis.