tbuckley/cabot-search huggingface dataset:
Primary Cardiac Hemangiopericytoma on 18F-FDG and 68Ga-FAPI-04 PET/CT
Authors: Chuan Li, Yichuan Deng, Xianwen Hu
Journal: Clinical Nuclear Medicine (2024)

Abstract Hemangiopericytoma can occur anywhere in the body, mainly including the head and neck soft tissue, retroperitoneum, limbs, lung, pleura, pelvis, and meninges, whereas it arising in cardiac is rarely documented. Herein, we report 18 F-FDG PET/CT and 68 Ga-FAPI findings of hemangiopericytoma in the heart in a 23-year-old woman.
Bilateral Internal Auditory Canal Metastasis From Lung Cancer on FDG PET/CT
Authors: Liu Xiao, Lin Li, Chunyan Wu, Wenjie Zhang
Journal: Clinical Nuclear Medicine (2024)

The occurrence of metastatic tumor in the internal auditory canal is very rare. Thus, we report FDG PET/CT findings of bilateral Internal auditory canal metastasis from lung cancer in a 67-year-old man. FDG PET/CT and MRI showed nodules in the bilateral internal auditory canal with an SUV max of 5.2. This case hints us that bilateral metastasis should be considered as differential diagnosis when we encounter bilateral nodule in the internal auditory.
Uptake of 68Ga-DOTA-FAPI-04 in a Case of Gynecomastia
Authors: Tingting Xu, Feiyu Zhang, Shiyu Zheng, Yue Chen
Journal: Clinical Nuclear Medicine (2024)

Herein, we report a case of a man with malignant melanoma exhibiting thickened right breast with increased tracer uptake on 68 Ga-DOTA-FAPI-04 PET/CT. Subsequent ultrasound confirmed there was no sign of malignancy and consistent with benign gynecomastia.
An Incidental Detection of Breast Cancer Osteolytic Bone Metastasis Using a 99mTc-TRODAT-1 SPECT Scan
Authors: Chun-Liang Kuo, Yu-Hong Chang, Rong-Hsin Yang
Journal: Clinical Nuclear Medicine (2024)

Abstract This report presents a case of suspected Parkinson disease in a 76-year-old woman with a history of slurred speech, general weakness, unstable gait, and bradykinesia for months. A 99m Tc-TRODAT-1 SPECT scan revealed a symmetrically decreased bilateral nigrostriatal system, including bilateral putamen and caudate nuclei. The scintigraphic findings may reflect normal aging or atypical parkinsonism. The bilateral frontal bones and left temporal bone exhibited increased uptake of 99m Tc-TRODAT-1, and previous 99m Tc-MDP bone scan and CT images were reviewed. Osteolytic lesions at the corresponding site indicated bone metastasis from breast cancer.
Organomics
Authors: Yazdan Salimi, Ghasem Hajianfar, Zahra Mansouri, Amirhosein Sanaat, Mehdi Amini, Isaac Shiri, Habib Zaidi
Journal: Clinical Nuclear Medicine (2024)

Purpose Non–small cell lung cancer is the most common subtype of lung cancer. Patient survival prediction using machine learning (ML) and radiomics analysis proved to provide promising outcomes. However, most studies reported in the literature focused on information extracted from malignant lesions. This study aims to explore the relevance and additional value of information extracted from healthy organs in addition to tumoral tissue using ML algorithms. Patients and Methods This study included PET/CT images of 154 patients collected from available online databases. The gross tumor volume and 33 volumes of interest defined on healthy organs were segmented using nnU-Net deep learning–based segmentation. Subsequently, 107 radiomic features were extracted from PET and CT images (Organomics). Clinical information was combined with PET and CT radiomics from organs and gross tumor volumes considering 19 different combinations of inputs. Finally, different feature selection (FS; 5 methods) and ML (6 algorithms) algorithms were tested in a 3-fold data split cross-validation scheme. The performance of the models was quantified in terms of the concordance index (C-index) metric. Results For an input combination of all radiomics information, most of the selected features belonged to PET Organomics and CT Organomics. The highest C-index (0.68) was achieved using univariate C-index FS method and random survival forest ML model using CT Organomics + PET Organomics as input as well as minimum depth FS method and CoxPH ML model using PET Organomics as input. Considering all 17 combinations with C-index higher than 0.65, Organomics from PET or CT images were used as input in 16 of them. Conclusions The selected features and C-indices demonstrated that the additional information extracted from healthy organs of both PET and CT imaging modalities improved the ML performance. Organomics could be a step toward exploiting the whole information available from multimodality medical images, contributing to the emerging field of digital twins in health care.
The Value of PSMA-RADS Version 2.0 in the Assessment of Pulmonary Metastases in Patients With Prostate Cancer and the Improvement of Differential Diagnosis Efficiency by PSMA PET/CT Parameters
Authors: Yan Cui, Xin Zhou, Yufei Song, Shizhen Zhai, Nan Li
Journal: Clinical Nuclear Medicine (2024)

The aim of this study was to investigate the application of PSMA-RADS version 2.0 in assessment of pulmonary metastases in patients with prostate cancer and whether PSMA PET/CT parameters provide incremental value.
PET/CT Manifestations of a Case of Cavernous Hemangioma Misdiagnosed as Reproductive Tumor
Authors: Tao Liu, You Cheng, Jian-Jiang Huang, Dan Shao, Si-yun Wang
Journal: Clinical Nuclear Medicine (2024)

Cavernous hemangioma of mediastinum is a rare, benign tumor originating from vascular endothelial cells. It typically arises in the anterior mediastinum but has also been reported in the posterior mediastinum or the middle mediastinum, and occasionally involves both the anterior and middle compartments. We present the case of a 20-year-old man with a cavernous hemangioma of mediastinum initially misdiagnosed as a reproductive tumor by 18 F-FDG PET/CT.
Hot Hearts on Bone Scintigraphy Are Not All Amyloidosis
Authors: Ya-Wen Wang, Yan-Ting Xie, Xiao-Xin Sun
Journal: Clinical Nuclear Medicine (2024)

Abstract A 54-year-old woman with a history of end-stage renal disease was found to have infiltrative cardiomyopathy by echocardiography. 99m Tc-pyrophosphate ( 99m Tc-PYP) scintigraphy was positive with a remarkable myocardial uptake. Gene test found a mutation of AGXT , confirming a final diagnosis of primary hyperoxaluria. Radiotracer uptake was due to high myocardial oxalate deposition. This case illustrates false positivity of the 99m Tc-PYP scan caused by hyperoxaluria-associated cardiomyopathy, which raises awareness for other conditions apart from amyloid cardiomyopathy.
Incidental Uptake of 68Ga-DOTA-IBA in Prostate Adenocarcinoma
Authors: Huipan Liu, Yuhong Liu, Feifan Xiang, Jianwen Zhang, Yue Chen
Journal: Clinical Nuclear Medicine (2024)

68 Ga-labeled DOTA-ibandronic acid ( 68 Ga-DOTA-IBA) is a novel PET agent developed for bone tumors. In addition, 68 Ga-DOTA-IBA uptake in nonosseous findings has also been reported. Herein, we present a case of 68 Ga-DOTA-IBA uptake in primary prostate adenocarcinoma.
Detection of Muscular Metastasis in a Case of Parathyroid Carcinoma Using 18F-FAPI-04 PET/CT
Authors: Jie Chen, Min Zhao, Qi An, Lan Wei, Bin Chen
Journal: Clinical Nuclear Medicine (2024)

A 46-year-old woman underwent surgery for parathyroid carcinoma 2 years ago. During follow-up, the patient presented with elevated parathyroid hormone (127.50 pg/mL; normal, 15-65). No abnormal uptake of 18 F-FDG or 11 C-choline was observed on 18 F-FDG and 11 C-choline PET/CT imaging. The patient was enrolled in a clinical trial for 18 F-FAPI PET/CT imaging, revealing a lesion with intense focal uptake within the left sternocleidomastoid muscle. The patient underwent surgery. Postoperative pathology and immunohistochemical analysis confirmed parathyroid carcinoma metastasis.
Elevated 68Ga-FAPI Activity in Tailgut Cyst Adenocarcinoma
Authors: Yilin Huang, Lei Ou, Chengrun Zeng, Xiaoliang Chen
Journal: Clinical Nuclear Medicine (2024)

Tailgut cyst adenocarcinoma is a rare malignant tumor. We present 68 Ga-FAPI PET/CT findings of tailgut cyst adenocarcinoma in a 46-year-old woman. Tailgut cyst adenocarcinoma on 68 Ga-FAPI PET/CT showed increased tracer uptake. This case demonstrates the potential value of 68 Ga-FAPI PET/CT for evaluating tailgut cyst adenocarcinoma.
Early Impact of Bevacizumab on the 99mTc-HYNIC-PSMA-11 Uptake in a Case of Recurrent Glioblastoma Multiforme
Authors: Tahereh Ghaedian, Abdolmajid Alipour, Abbas Rakhsha, Hamid Nasrollahi, Arash Saffarian
Journal: Clinical Nuclear Medicine (2024)

Glioblastoma multiforme (GBM) is a highly vascularized tumor with reported high prostate-specific membrane antigen (PSMA) expression. On the other hand, bevacizumab as an antiangiogenesis drug is increasingly used in the treatment of GBM recurrence. We present a case of GBM recurrence with significant reduction of 99m Tc-HYNIC-PSMA-11 uptake in her tumor 1 week after administration of 2 doses of bevacizumab with 2 weeks' interval. This case emphasizes the main mechanism of PSMA uptake in GBM secondary to angiogenesis and also implies a potential interaction of bevacizumab with PSMA uptake that should be especially considered during diagnostic and therapeutic application of PSMA radiotracers in GBM.
Pertussis upsurge, age shift and vaccine escape post-COVID-19 caused by ptxP3 macrolide-resistant Bordetella pertussis MT28 clone in China
Authors: Pan Fu, Gangfen Yan, Yijia Li, Li Xie, Yuehua Ke, Shuxiang Qiu, Shuang Wu, Xiaolu Shi, Jie Qin, Jinlan Zhou, Guoping Lu, Chao Yang, Chuanqing Wang
Journal: Clinical Microbiology and Infection (2024)
Reliability of Intestinal Ultrasound for Evaluating Crohn’s Disease Activity Using Point-of-care and Central Reading
Authors: Thomas M. Goodsall, Yoon-Kyo An, Jane M. Andrews, Jakob Begun, Antony B. Friedman, Andrew Lee, Peter J. Lewindon, Paul Spizzo, Nick Rodgers, Kirstin M. Taylor, Lauren S. White, Rune Wilkens, Emily K. Wright, Lily Zou, Bryan R. Maguire, Claire E. Parker, Julie Rémillard, Kerri L. Novak, Remo Panaccione, Brian G. Feagan, Vipul Jairath, Christopher Ma, Robert V. Bryant
Journal: Clinical Gastroenterology and Hepatology (2024)
Thiopurines and the Risk of Cancer in Patients with Inflammatory Bowel Disease and Reference Individuals without Inflammatory Bowel Disease – A Danish Nationwide Cohort Study (1996-2018)
Authors: Mads Damsgaard Wewer, Gasper Letnar, Klaus Kaae Andersen, Mikkel Malham, Vibeke Wewer, Jakob Benedict Seidelin, Flemming Bendtsen, Johan Burisch
Journal: Clinical Gastroenterology and Hepatology (2024)

Background & AimsThiopurine therapy is a cornerstone in the treatment of inflammatory bowel disease (IBD). We aimed to assess the effect of thiopurines on cancer risk in IBD according to drug exposure and age.MethodsDanish national registers were used to identify incident IBD patients, exposure to drugs, and status of cancers, in 1996 to 2018. Cox regressions were used to compare cancer risks in IBD and non-IBD individuals and to assess IBD patients' cumulative drug exposure and the association to first cancer, excluding non-melanoma skin cancer.ResultsWe followed 43,419 patients with IBD for a median of 8.2 years (interquartile range, 3.7–14.2 years) after IBD diagnosis. Cancer was reported in 3128 (7.2%) patients with IBD. The risk of cancer was increased in patients with IBD in all age categories compared with non-IBD individuals (<50 years: adjusted hazard ratio [aHR], 1.59; 95% confidence interval [CI], 1.43–1.77; 50–65 years: aHR, 1.31; 95% CI, 1.19–1.44; and >65 years: aHR, 1.14; 95% CI, 1.05–1.24). Monotherapy (aHR, 1.36; 95% CI, 1.17–1.57) and combination therapy (aHR, 2.49; 95% CI, 1.64–3.78) were associated with an increased risk of cancer compared to unexposed patients with IBD. Among elderly patients (>65 years), the aHR was 2.79 (95% CI, 1.24–6.28) in those receiving combination therapy. In patients discontinuing thiopurines, aHRs returned to the level of unexposed (aHR, 0.89; 95% CI, 0.78–1.01). The aHR was positively associated with cumulative thiopurine exposure and in patients with >5 years of exposure, reaching an aHR of 1.36 (95% CI, 1.15–1.61).ConclusionsThiopurines were associated with increased hazard of cancer, especially when used in combination therapy in the elderly. The hazard increased by 36% when patients were exposed to thiopurines for more than 5 years. Reassuringly, the hazard returned to baseline after discontinuation of thiopurines.
Association of Food Insecurity with the Prevalence and Liver-related Mortality of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Authors: Zobair M. Younossi, Shira Zelber-Sagi, Carina Kuglemas, Jeffrey V. Lazarus, Annette Paik, Leyla de Avila, Lynn Gerber, James M. Paik
Journal: Journal of Hepatology (2024)
A Small TAT-TrkB Peptide Prevents BDNF Receptor Cleavage and Restores Synaptic Physiology in Alzheimer’s Disease
Authors: João Fonseca-Gomes, Tiago Costa-Coelho, Mafalda Ferreira-Manso, Sara Inteiro-Oliveira, Sandra H. Vaz, Nuno Alemãn-Serrano, Henrique Atalaia-Barbacena, Leonor Ribeiro-Rodrigues, Rita M. Ramalho, Rui Pinto, Hugo Vicente Miranda, Sara R. Tanqueiro, Carolina de Almeida-Borlido, Maria João Ramalho, Catarina Miranda-Lourenço, Rita F. Belo, Catarina B. Ferreira, Vera Neves, Diogo M. Rombo, Ricardo Viais, Juzoh Umemori, Ivo C. Martins, André Jerónimo-Santos, António Caetano, Nuno Manso, Petra Mäkinen, Mikael Marttinen, Mari Takalo, Michael Bremang, Ian Pike, Annakaisa Haapasalo, Joana A. Loureiro, Maria Carmo Pereira, Nuno C. Santos, Tiago F. Outeiro, Miguel A.R.B. Castanho, Adelaide Fernandes, Mikko Hiltunen, Carlos B. Duarte, Eero Castrén, Alexandre de Mendonça, Ana M. Sebastião, Tiago M. Rodrigues, Maria José Diógenes
Journal: Molecular Therapy (2024)

In Alzheimer's disease (AD), amyloid β (Aβ)-triggered cleavage of TrkB-FL impairs brain-derived neurotrophic factor (BDNF) signaling, thereby compromising neuronal survival, differentiation, and synaptic transmission and plasticity. Using cerebrospinal fluid and postmortem human brain samples, we show that TrkB-FL cleavage occurs from the early stages of the disease and increases as a function of pathology severity. To explore the therapeutic potential of this disease mechanism, we designed small TAT-fused peptides and screened their ability to prevent TrkB-FL receptor cleavage. Among these, a TAT-TrkB peptide with a lysine-lysine linker prevented TrkB-FL cleavage both in vitro and in vivo and rescued synaptic deficits induced by oligomeric Aβ in hippocampal slices. Furthermore, this TAT-TrkB peptide improved the cognitive performance, ameliorated synaptic plasticity deficits and prevented Tau pathology progression in vivo in the 5XFAD mouse model of AD. No evidence of liver or kidney toxicity was found. We provide proof-of-concept evidence for the efficacy and safety of this therapeutic strategy and anticipate that this TAT-TrkB peptide has the potential to be a disease-modifying drug that can prevent and/or reverse cognitive deficits in patients with AD.Graphical abstract
Predictors of Functional Cure of Chronic Hepatitis B Virus Infection: A Long-Term Follow-Up Study
Authors: Jia-Feng Wu, Chi-San Tai, Kai-Chi Chang, Yuh-Jue Chen, Chien-Ting Hsu, Huey-Ling Chen, Yen-Hsuan Ni, Mei-Hwei Chang
Journal: Clinical Gastroenterology and Hepatology (2024)
Performance of AI-Enabled Electrocardiogram in the Prediction of Metabolic Dysfunction-Associated Steatotic Liver Disease
Authors: Prowpanga Udompap, Kan Liu, Itzhak Zachi Attia, Rachel E Canning, Joanne T Benson, Terry M Therneau, Peter A Noseworthy, Paul A Friedman, Puru Rattan, Joseph C Ahn, Douglas A Simonetto, Vijay H Shah, Patrick S Kamath, Alina M Allen
Journal: Clinical Gastroenterology and Hepatology (2024)
Systematic Review and Meta-analysis: The Three-year Post-colonoscopy Colorectal Cancer Rate as per the World Endoscopy Organization Methodology
Authors: Rawen Kader, Andreas V. Hadjinicolaou, Nicholas E. Burr, Paul Bassett, Omer F. Ahmad, Lasse Pedersen, Manish Chand, Roland Valori, Danail Stoyanov, Laurence B. Lovat
Journal: Clinical Gastroenterology and Hepatology (2024)

In 2018, the World Endoscopy Organization (WEO) introduced standardized methods for calculating post-colonoscopy colorectal cancer-3yr rates (PCCRC-3yr). This systematic review aimed to calculate the global PCCRC-3yr according to the WEO methodology, its change over time, and to measure the association between risk factors and PCCRC occurrences.
Vonoprazan as a Long-term Maintenance Treatment for Erosive Esophagitis: VISION, a 5-Year, Randomized, Open-label Study
Authors: Naomi Uemura, Yoshikazu Kinoshita, Ken Haruma, Ryoji Kushima, Takashi Yao, Junichi Akiyama, Nobuo Aoyama, Yuji Baba, Chihiro Suzuki, Kaori Ishiguro
Journal: Clinical Gastroenterology and Hepatology (2024)

Acid secretion inhibitors are associated with hypergastrinemia, which can lead to gastric mucosal changes. Potassium-competitive acid blockers, such as vonoprazan, are more potent than proton pump inhibitors, but long-term safety data are lacking.
Is there an association between pelvic pain and gender-affirming testosterone therapy in trans masculine adolescents? An exploratory cross-sectional study
Authors: Dehlia Moussaoui, Monsurul Hoq, Charlotte V. Elder, Sonia R. Grover, Michele A. O'Connell, Ken C. Pang
Journal: International Journal of Transgender Health (2024)

Background High rates of pelvic pain have been reported in trans individuals on testosterone, but the pathophysiology of pain and the potential role of testosterone are unclear.
An integrated single-cell reference atlas of the human endometrium
Authors: Magda Marečková, Luz Garcia-Alonso, Marie Moullet, Valentina Lorenzi, Robert Petryszak, Carmen Sancho-Serra, Agnes Oszlanczi, Cecilia Icoresi Mazzeo, Frederick C. K. Wong, Iva Kelava, Sophie Hoffman, Michał Krassowski, Kurtis Garbutt, Kezia Gaitskell, Slaveya Yancheva, Ee Von Woon, Victoria Male, Ingrid Granne, Karin Hellner, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Mohammad Lotfollahi, Elena Prigmore, Jennifer Southcombe, Rebecca A. Dragovic, Christian M. Becker, Krina T. Zondervan, Roser Vento-Tormo
Journal: Nature Genetics (2024)

The complex and dynamic cellular composition of the human endometrium remains poorly understood. Previous endometrial single-cell atlases profiled few donors and lacked consensus in defining cell types. We introduce the Human Endometrial Cell Atlas (HECA), a high-resolution single-cell reference atlas (313,527 cells) combining published and new endometrial single-cell transcriptomics datasets of 63 women with and without endometriosis. HECA assigns consensus and identifies previously unreported cell types, mapped in situ using spatial transcriptomics and validated using a new independent single-nuclei dataset (312,246 nuclei, 63 donors). In the functionalis, we identify intricate stromal-epithelial cell coordination via transforming growth factor beta (TGFβ) signaling. In the basalis, we define signaling between fibroblasts and an epithelial population expressing progenitor markers. Integration of HECA with large-scale endometriosis genome-wide association study data pinpoints decidualized stromal cells and macrophages as most likely dysregulated in endometriosis. The HECA is a valuable resource for studying endometrial physiology and disorders, and for guiding microphysiological in vitro systems development.
Keratin variants in monilethrix
Authors: Daniela Ortner-Tobider, Thomas Trafoier, Verena Moosbrugger-Martinz, Susanne Tollinger, Robert Gruber, Matthias Schmuth
Journal: British Journal of Dermatology (2024)

Journal Article Accepted manuscript Keratin variants in monilethrix Get access Daniela Ortner-Tobider, Daniela Ortner-Tobider Department of Dermatology, Venereology and Allergy, Medical University of Innsbruck; Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar Thomas Trafoier, Thomas Trafoier Department of Dermatology, Venereology and Allergy, Medical University of Innsbruck; Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar Verena Moosbrugger-Martinz, Verena Moosbrugger-Martinz Department of Dermatology, Venereology and Allergy, Medical University of Innsbruck; Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar Susanne Tollinger, Susanne Tollinger Department of Dermatology, Venereology and Allergy, Medical University of Innsbruck; Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar Robert Gruber, Robert Gruber Department of Dermatology, Venereology and Allergy, Medical University of Innsbruck; Innsbruck, AustriaKarl Landsteiner Institute for Pediatric Dermatology and Rare Diseases, Innsbruck, AustriaEuropean Reference Network for rare skin diseases (ERN Skin), Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar Matthias Schmuth Matthias Schmuth Department of Dermatology, Venereology and Allergy, Medical University of Innsbruck; Innsbruck, AustriaKarl Landsteiner Institute for Pediatric Dermatology and Rare Diseases, Innsbruck, AustriaEuropean Reference Network for rare skin diseases (ERN Skin), Innsbruck, Austria Correspondence: Matthias Schmuth Email:matthias.schmuth@i-med.ac.at https://orcid.org/0000-0002-4064-1334 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, ljae340, https://doi.org/10.1093/bjd/ljae340 Published: 28 August 2024 Article history Received: 21 August 2024 Revision received: 22 August 2024 Accepted: 26 August 2024 Published: 28 August 2024
Update on Pediatric Cancer Surveillance Recommendations for Patients with Neurofibromatosis Type 1, Noonan Syndrome, CBL Syndrome, Costello Syndrome, and Related RASopathies
Authors: Melissa R. Perrino, Anirban Das, Sarah R. Scollon, Sarah G. Mitchell, Mary-Louise C. Greer, Marielle E. Yohe, Jordan R. Hansford, Jennifer M. Kalish, Kris Ann P. Schultz, Suzanne P. MacFarland, Wendy K. Kohlmann, Philip J. Lupo, Kara N. Maxwell, Stefan M. Pfister, Rosanna Weksberg, Orli Michaeli, Marjolijn C.J. Jongmans, Gail E. Tomlinson, Jack Brzezinski, Uri Tabori, Gina M. Ney, Karen W. Gripp, Andrea M. Gross, Brigitte C. Widemann, Douglas R. Stewart, Emma R. Woodward, Christian P. Kratz
Journal: Clinical Cancer Research (2024)

Abstract Neurofibromatosis type 1 (NF1), Noonan syndrome, and related syndromes, grouped as RASopathies, result from dysregulation of the RAS-MAPK pathway and demonstrate varied multisystemic clinical phenotypes. Together, RASopathies are among the more prevalent genetic cancer predisposition syndromes and require nuanced clinical management. When compared with the general population, children with RASopathies are at significantly increased risk of benign and malignant neoplasms. In the past decade, clinical trials have shown that targeted therapies can improve outcomes for low-grade and benign neoplastic lesions but have their own challenges, highlighting the multidisciplinary care needed for such individuals, specifically those with NF1. This perspective, which originated from the 2023 American Association for Cancer Research Childhood Cancer Predisposition Workshop, serves to update pediatric oncologists, neurologists, geneticists, counselors, and other health care professionals on revised diagnostic criteria, review previously published surveillance guidelines, and harmonize updated surveillance recommendations for patients with NF1 or RASopathies.
CD94<sup>+</sup>natural killer cells potentiate pulmonary ischaemia–reperfusion injury
Authors: Tasha Tsao, Longhui Qiu, Reena Bharti, Avishai Shemesh, Alberto M. Hernandez, Simon J. Cleary, Nancy Y. Greenland, Jesse Santos, Ruoshi Shi, Lu Bai, Jennifer Richardson, Kimberley Dilley, Matthias Will, Nenad Tomasevic, Tereza Sputova, Adam Salles, Jeffrey Kang, Dongliang Zhang, Steven R. Hays, Jasleen Kukreja, Jonathan P. Singer, Lewis L. Lanier, Mark R. Looney, John R. Greenland, Daniel R. Calabrese
Journal: European Respiratory Journal (2024)

Pulmonary ischaemia-reperfusion injury (IRI) is a major contributor to poor lung transplant outcomes. We recently demonstrated a central role of airway-centred natural killer (NK) cells in mediating IRI; however, there are no existing effective therapies for directly targeting NK cells in humans.