tbuckley/cabot-search huggingface dataset:
The Significance of the Physical Constitution in Mental Disease.
Authors: Fredric Wertham, Florence E. Hesketh Wertham
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 124: Postischemic Induction of IL-17 Signaling Promotes Necrotic and Apoptotic Cell Death in the Rat Heart Exposed to in Vivo Ischemia/Reperfusion Injury
Authors: Sean Berry, Anastasis Stephanou, Giuseppe Faggian, Alessandro Mazzucco, Louis Saravolatz, Qureshi Waqas, Wen-Shi Shieh, Gabriele Scarabelli, Carol Chen-Scarabelli, Tiziano M Scarabelli
Journal: Circulation (2011)

Background. L-17A and IL-17F are pro-inflammatory cytokines, which induce the expression of several cytokines, chemokines and matrix metalloproteinases (MMPs) in target cells. IL-17 effector protei...
OBSERVATIONS FROM FORTY YEARS OF MEDICAL TEACHING
Authors: J E PAULLIN
Journal: Annals of Internal Medicine (1950)

ExcerptThe improvement of medical teaching, research and education, and the betterment of medical practice, are the chief purposes of The American College of Physicians. Observations on medical education resulting from my experience as a teacher constitute the basis of this presentation. It is realized that there are several schools of thought concerning the problems of pre-medical and medical training, all of them with much merit; no attempt will be made to settle any of the controversial issues. I am adding my thoughts for what they are worth to the thinking of others along this line, with the idea that those...
Guy Patin and the Medical Profession in Paris in the XVIIth Century.
Authors: Francis R. Packard, Guy Patin
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chinese herbs nephropathy and urinary tract carcinoma
Authors: Joëlle Nortier, Jonathan Simon, Michel Petein, Luc De Pauw, Joseph Kerger, Paul Kinnaert, Nicolas Pelgrims De Bigard, Michel Depierreux, Karl Martin Wissing, Daniel Abramowicz, Jean-Louis Vanherweghem
Journal: Journal of the American Society of Nephrology (1998)
Combined 18F-NaF and 18F-FDG PET/CT in the Evaluation of Sarcoma Patients
Authors: Tatianie Jackson, Camila Mosci, Rie von Eyben, Erik Mittra, Kristen Ganjoo, Sandip Biswal, Sanjiv Sam Gambhir, Andrei Iagaru
Journal: Clinical Nuclear Medicine (2015)

The combined administration of F-NaF and F-FDG in a single PET/CT scan has the potential to improve patient convenience and cancer detection. Here we report the use of this approach for patients with sarcomas.This is a retrospective review of 21 patients (12 men, 9 women; age, 19-66 years) with biopsy-proven sarcomas who had separate F-NaF PET/CT, F-FDG PET/CT, and combined F-NaF/F-FDG PET/CT scans for evaluation of malignancy. Two board-certified nuclear medicine physicians and 1 board-certified musculoskeletal radiologist were randomly assigned to review the scans. Results were analyzed for sensitivity and specificity, using linear regression and receiver operating characteristics.A total of 13 patients had metastatic disease on F-NaF PET/CT, F-FDG PET/CT, and combined F-NaF/F-FDG PET/CT. Skeletal disease was more extensive on the F-NaF PET/CT scan than on the F-FDG PET/CT in 3 patients, whereas in 1 patient, F-FDG PET/CT showed skeletal disease and the F-NaF PET/CT was negative. Extraskeletal lesions were detected on both F-FDG and combined F-NaF/F-FDG PET/CT in 20 patients, with 1 discordant finding in the lung.The combined F-NaF/F-FDG PET/CT scan allows for accurate evaluation of sarcoma patients. Further evaluation of this proposed imaging modality is warranted to identify the most suitable clinical scenarios, including initial treatment strategy and evaluation of response to therapy.
Quality of life (QoL) in SAKK 19/03: A multicenter phase II study of first-line gefitinib followed by chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). Swiss Group for Clinical Cancer Research (SAKK)
Authors: G. D’Addario, F. Strasser, K. Ribi, D. Rauch, R. Stupp, M. Pless, R. A. Stahel, K. Rufibach, S. Lerch, D. Betticher
Journal: Journal of Clinical Oncology (2006)

18559 Background: 63 patients (pts) were accrued in this first study testing first-line tyrosine-kinase inhibitor treatment with gefitinib followed by chemotherapy at disease progression (gemcitabine-cisplatin q3w x6, 41 pts) in stage IIIB/IV NSCLC (ASCO 2005 # 7128). We investigated the longitudinal QoL patterns on both subsequent treatment modalities. Methods: FACT-L including TOI (Trial Outcome Index) and LCS (Lung Cancer Subscale) scores were assessed during both treatment phases (gefitinib: baseline, weeks 3,6,12,18 and every 12 weeks thereafter; chemotherapy: baseline and at d1 of cycle 3 and 5). QoL changes from baseline were descriptively analysed. Improvement was defined as a 6 point (FACT-L, TOI) and 2 point (LCS) increase. Results: QoL-scores are shown in the table below. On gefitinib, at week 6 31/18/32% of pts had improvements of FACT-L, TOI and LCS, respectively and 29/15/41% at week 12 (% based on pts with available data). During chemotherapy the respective improvement rates were 60/60/70% of pts at week 6 and 43/29/43% at week 12. At week 12 of gefitinib, 4 of the pts analysed had partial remission (PR, independently confirmed), 31 pts dropped out (none due to toxicity) and QoL submission rate was 84% based on expected forms. Chemotherapy week 12: 5 PR in analysed pts, 18 drop outs (5 due to toxicity), 43% submission rate. Conclusions: QoL was maintained in pts continuing treatment with gefitinib and decreased at disease progression. QoL and tumor symptoms improved in a considerable part of pts during gefitinib therapy despite low remission rates. Declining submission rate during treatment introduces a potential, unquantifiable bias in QoL. [Table: see text] [Table: see text]
Outcome prediction to cetuximab in advanced colorectal cancer: Analysis of EGFR and HER2 gene copy number by fluorescence in situ hybridization
Authors: N. Personeni, G. De Hertogh, S. Störkel, M. Debiec-Rychter, K. Geboes, W. De Roock, Y. Humblet, H. Piessevaux, E. Van Cutsem, S. Tejpar
Journal: Journal of Clinical Oncology (2007)

10569 Background: Recent studies suggest that increased epidermal growth factor receptor (EGFR) gene copy number assessed by in situ hybridization predicts response to cetuximab in patients (pts) with advanced colorectal cancer (mCRC). Additionally, preclinical data indicate that HER2, a member of the EGFR family, can modulate the efficacy of anti-EGFR monoclonal antibodies. Methods: We assessed EGFR and HER2 gene copies by fluorescent in situ hybridization (FISH) on paraffin-embedded samples from 70 pts with mCRC treated with cetuximab alone or with irinotecan. FISH was assessed either on primary tumors (55 pts) or on metastases (15 pts) according to two parameters: the absolute copy number of genes and chromosome (chr) centromeres, and their frequencies in 100 tumor cells. A sensitivity analysis was performed and fitted to outcome data in an attempt to define relevant cutoffs. EGFR protein expression by immunohistochemistry was deemed positive with =10% tumor cells being stained. Multiple paired samples originating from different tumor sources were analyzed whenever available (27 pts). Results: The overall response rate was 25%. Prevalent FISH patterns were disomy (8%) and balanced polysomy (90%) for EGFR gene and chr 7. EGFR amplification was seen in two pts (2%), of which only one responded. HER2 amplification was seen in two of 54 pts (3%), both experiencing stable disease. Average EGFR copies and frequency of tumor cells with &gt;2 copies respectively ranged from 1.6 to 4.0 and from 10% to 90%, thus reflecting a substantial tumor heterogeneity. Despite assessing multiple centile cutoffs of gene copy numbers and their frequencies in tumor cells, we found no association between EGFR and HER2 copy numbers and objective response, time to progression, and overall survival. Analysis of paired samples did not improve the predictive value of EGFR copies by FISH. Excluding EGFR amplification, associated to a strong (3+) EGFR staining, we found no correlation between EGFR copy number and protein expression. Conclusions: Neither EGFR nor HER2 copies by FISH, nor EGFR expression, are predictors of outcome in mCRC pts treated with cetuximab. FISH might still play a role in screening EGFR and HER2 amplification, but cost-effectiveness is debatable. [Table: see text]
Regional Arterial Therapy in the Management of Primary Liver Neoplasms
Authors: Yehuda Z. Patt, Chusilp Charnsangavej, Marilyn Soski, Giora M. Mavligit
Journal: Liver Cancer (1985)

Survival of untreated patients with inoperable primary liver neoplasms is approximately 75 days [1,2]. Before doxorubicin, both intravenous and intra-arterial chemotherapeutic agents had very little effect upon the survival of these patients despite tumor shrinkage [3,4]. An early report with doxorubicin, given intravenously as a single agent or in combination with other drugs, resulted in a response of 78% [5]. Later studies reported response rates ranging from 9% to 44% [6–14]. In 67% of patients with primary liver neoplasms, disease seems confined to the liver at the time of diagnosis, and even at autopsy disease is still confined to the liver in 44% of the patients [15]. A regional approach to a disease with such dismal prognosis seems warranted. A pilot study of hepatic arterial infusion of floxuridine, doxorubicin, and mitomycin C (FUDRAM) resulted in a response rate of 66% in patients with hepatocellular carcinoma [16]. We decided, therefore, to explore this treatment regimen further, and in this chapter we describe our experience and discuss the possible role of intrahepatic artery chemotherapy in primary liver cancer.
Abstract 1679: Multi-vessel versus Single-Vessel Spasm induced by Intracoronary Acetylcholine Provocation Test
Authors: Zhe Jin, Seung W Rha, Minami Yoshiyasu, Ji H Kim, Jin O Na, Soon Y Suh, Cheol U Choi, Jin W Kim, Eung J Kim, Chang G Park, Hong S Seo, Dong J Oh
Journal: Circulation (2007)

Background:  Coronary artery spasm is known to be an important cause of myocardial ischemia. Compared with single-vessel spasm, multi-vessel spasm may induce more severe and prolonged myocardial ischemia. We assessed whether there are different angiographic and clinical characteristics between the multi-vessel spasm and single-vessel spasm induced by intracoronary acetylcholine (Ach) provocation test.   Methods:  Study population consisted of 1,207 patients (pts, male 56.4%, age 57.7±11.1 years) who underwent coronary angiography with intracoronary Ach provocation test between Nov 2004 and Feb 2007. A total of 480 pts (39.8%) showed significant Ach-induced endothelial dysfunction. Clinical and angiographic parameters of multi-vessel spasm group (n=191, 39.8%) were compared with those of single-vessel spasm group (n=289, 60.2%).   Results:  Baseline characteristics were similar between two groups. Multi-vessel spasm group showed more typical chest pain and ST-T EKG changes during the Ach provocation test. Multi-vessel spasm group showed more vulnerable response to the lower Ach dose (20 to 50 μg). In addition, diffuse and severe spasms were more frequent in multi-vessel spasm group.   Conclusion:  Multi-vessel spasm group showed higher frequency of typical chest pain, ECG change during the intracoronary Ach provocation test and showed enhanced vasoconstriction response to lower Ach dose and diffuse, severe coronary spasm compared with single-vessel spasm group.
Mental Health and the Prevention of Neurosis
Authors: Joachim Flescher, Nolan Don Carpentier Lewis
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor-Localizing Antibodies Purified from Antisera against Murphy Rat Lymphosarcoma&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: E D DAY, L KORNGOLD, J PLANINSEK, D PRESSMAN
Journal: JNCI Journal of the National Cancer Institute (1956)

Tumor-Localizing Antibodies Purified from Antisera against Murphy Rat Lymphosarcoma Get access Eugene D. Day, Eugene D. Day Search for other works by this author on: Oxford Academic PubMed Google Scholar Jakob Planinsek, Jakob Planinsek Search for other works by this author on: Oxford Academic PubMed Google Scholar Leonhard Korngold, Leonhard Korngold Search for other works by this author on: Oxford Academic PubMed Google Scholar David Pressman David Pressman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 4, October 1956, Pages 517–532, https://doi.org/10.1093/jnci/17.4.517 Published: 01 October 1956 Article history Received: 19 June 1956 Published: 01 October 1956
Allgemeine Prognostik. Oder die Lehre von der ärztlichen Beurteilung des gesunden und kranken Menschen.
Authors: Theodor Brugsch
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Travellers: Narratives from the Seventeenth, Eighteenth, and Nineteenth Centuries.
Authors: John David Spillane
Journal: Annals of Internal Medicine (1985)

Reviewsinvestment is credited with promoting further improvement until the late 1930s.Thereafter, the economy lagged, but mortality continued to decline; a circumstance that argues for the success of modern medicine in fighting disease.The data on mortality since Castro's coming to power is also revealing.Between 1959 and 1980, average life expectancy increased eight to nine years, to the point that it is virtually on a par with that of the United States.Also the infant mortality rate declined from 46+ deaths per thousand live births (1969) to less than twenty per thousand (1979), and without significant distinction between rates in urban and rural areas.Because economic growth under Castro has been minimal, the author concludes that more equitable distribution of wealth, and equalized access to health care accounted for these gains.This collection of mortality data and disease information is immensely valuable-even fascinating-and the demographic analysis highly informed.And, indeed, one is left wanting more.It appears a reflection of the sources that the emphasis is weighted heavily toward the pre-1959 period, thus the data from Castro years seems rather lean.Similarly, the omission of economic data tempers the strength of the author's claims about the relative importance of economic growth as a determinant of mortality decline.Finally, except for the separate focus on the municipality of Havana, the author deals with the Cuban population as a whole.This misses the opportunity to distinguish mortality and morbidity trends, especially in the pre-Castro years, as related to wealth, occupation, and levels of nutrition.That is more the realm of epidemiology, I know, but grouping mortality data according to socio-economic status is of critical importance in evaluating the scope of Cuba's health revolution.The fact that over the past two decades equalized access to health care has fostered mortality decline raises important questions about the organization and performance of Cuban medicine before and since Castro.Most provocative is the possibility that the Mexicos and Brazils that are chasing social progress through "modernization" might well study the example of Cuba for insight into improving life expectancy and bringing down infant mortality rates.It is certainly to its credit that this book provokes such issues, and invites further inquiry.
Virus Isolated from Avian Lymphomas Unrelated to Lymphomatosis Virus
Authors: B. R. Burmester, G. R. Sharpless, A. K. Fontes
Journal: JNCI Journal of the National Cancer Institute (1960)

A virus isolated from material known to contain virulent lymphomatosis virus has been shown to be antigenically unrelated to lymphomatosis and does not cause the disease. Because of its morphology, stability, and confinement to the nucleus, where it occurs in crystalline array, it is similar to the adenoviruses of man, and it is suggested that it be called GAL (Gallus, adeno-like) virus.
TMZ and PCV in unresectable high grade gliomas: a retrospective comparison between two common schedules
Authors: M. Quirino, M. Basso, N. Trigila, E. D’Argento, G. Schinzari, A. Iaculli, C. Pozzo, A. Cassano, M. Landriscina, C. Barone
Journal: Journal of Clinical Oncology (2005)

1580
Shedding of Ebola Virus in an Asymptomatic Pregnant Woman
Authors: Emma Akerlund, Joseph Prescott, Livia Tampellini
Journal: New England Journal of Medicine (2015)

Shedding of Ebola Virus in an Asymptomatic Pregnant WomanTo the Editor: In West Africa, the worst outbreak of Ebola virus disease (EVD) in history is continuing, with more than 11,100 deaths caused by the Zaire species (Zaire ebolavirus [EBOV]). 1 Symptoms include fever, headache, body pain, nausea with vomiting, diarrhea, hemorrhage, and symptoms of septic shock and multiorgan failure.It is thought that transmission occurs only through contact with body fluids from symptomatic patients. 2A 31-year-old woman in the late stage of a fifth pregnancy who had no history of coexisting illnesses or use of long-term medications presented to the hospital with suspected premature rupture of membranes.She was referred to the ELWA3 Ebola treatment unit (ETU) in Monrovia, Liberia, as was common practice in Monrovia for patients who potentially presented a hospital-exposure risk, such as during delivery.On admittance to the ETU, she had mild lower abdominal pain and sparse contractions and reported fetal movements (Fig. 1).She was afebrile and reported having had no contact with patients with EVD and did not meet the Ebola virus case definition.She underwent routine EBOV testing for anticipated transfer to the delivery clinic.On quantitative reverse-transcriptase-polymerase-chain-reaction (qRT-PCR) assay to detect L-gene sequences, her blood tested positive for EBOV, with a high viral load. 3Given the apparent asymptomatic presentation and since her acute symptoms were consistent with pregnancy-related issues, she was retested for EBOV on day 2, and the results were again positive.Additional EBOV testing was subsequently performed on blood and fluids to assess EBOV shedding to evaluate the potential risks associated with patient contact (Fig. 1), although no virus isolation was performed.All samples except those obtained from skin tested positive before the development of symptoms that were clearly associated with EVD.During the evening of day 3, she became mildly febrile and was considered to be symptomatic for EVD.During the following days, additional EVD-associated signs (vomiting, diarrhea,