tbuckley/cabot-search huggingface dataset:
Abstract 19119: Concomitant Use of Antiplatelet Therapy with Edoxaban or Warfarin in Patients with Atrial Fibrillation in the ENGAGE AF-TIMI 48 Trial
Authors: Haiyan Xu, Christian T Ruff, Robert P Giugliano, Sabina A Murphy, Indravadan Patel, Minggao Shi, Michele Mercuri, Elliott M Antman, Eugene Braunwald
Journal: Circulation (2014)

BACKGROUND: Patients with atrial fibrillation (AF) who receive both antiplatelet (AP) and anticoagulant therapy are at markedly higher risk of bleeding. The ENGAGE AF-TIMI 48 trial showed that both the high- (HD) and low-dose (LD) regimens of the once-daily factor Xa inhibitor edoxaban (Edox) were as effective as well-managed warfarin (Warf) (median TTR 68.4%) in preventing stroke or systemic embolism (SEE) with significant reductions in major bleeding and cardiovascular mortality. In this study, we assessed the relative efficacy and safety of Edox as compared with Warf in patients with and without concomitant use of AP therapy. METHODS: This was a randomized, double-blind, double-dummy trial comparing HD (60 mg daily, reduced to 30mg in patients with anticipated increased drug exposure) and LD (30 mg daily, reduced to 15mg) Edox with Warf. Dual AP therapy was prohibited while receiving study drug. Cox proportional hazards models were performed stratified by AP use at 3 months with treatment as a covariate. RESULTS: Of the 21,105 patients, 4,912 (23%) were receiving AP therapy at 3 months (92% aspirin). Patients who received concomitant AP therapy had higher rates of major bleeding compared to patients who did not (Fig). Both Edox regimens had similar relative efficacy in preventing stroke or SEE compared with Warf regardless of concomitant AP use (P int &gt;0.10 for both) with consistent reductions in major bleeding (HD Edox vs. Warf: P int =0.91; LD Edox vs. Warf: P int =0.59). In patients randomized to LD Edox, AP therapy was associated with a further reduction in the net clinical outcome of death, stroke, SEE, or major bleeding (P int =0.02) compared with Warf. CONCLUSIONS: Regardless of concomitant AP therapy, both doses of Edox significantly reduced bleeding compared to well-managed Warf. The safety profile of Edox may be particularly attractive in patients with AF who receive a combination of AP and anticoagulant therapy because of higher absolute risk of bleeding.
Mutation in the MME gene coding for neutral endopeptidase (NEP) are responsible for neonatal membranous glomerulonephritis (MGN) : role of IgG subclass and implications for pregnancy follow-up.
Authors: Hanna Debiec, Yasmina Tournay, Jeroen Nauta, Florence Coulet, Vincent Guigonis, Françoise Janssen, Danièle Vermeylen, Monique Deschodt Lanckman, Joëlle Nortier, Pierre Ronco
Journal: Journal of the American Society of Nephrology (2004)
Abstract 3469: OPG:TRAIL Ratio as a Potential Biomarker for Pulmonary Arterial Hypertension
Authors: Victoria Watt, Elaine Soon, Jay Suntharalingam, Claudia Paiva, Abdul G Hameed, Sheila E Francis, Christopher M Newman, David C Crossman, Nicholas W Morrell, Allan Lawrie
Journal: Circulation (2009)

Pulmonary arterial hypertension (PAH) is a life threatening condition with high morbidity and poor life expectancy. The pathology of PAH is characterised by the loss of small arteries in the lung s...
A Black-Box Warning for Antidepressants in Children?
Authors: Thomas B Newman
Journal: New England Journal of Medicine (2004)

On September 14, 2004, a Food and Drug Administration (FDA) joint advisory committee voted 15 to 8 to recommend that a “black-box” warning label be required for antidepressant drugs, indicating that they increase the risk of suicidal thinking and behavior (“suicidality”) in pediatric patients. Although, as an epidemiologist and general pediatrician, I do not have clinical experience caring for depressed patients, after reviewing the evidence, I strongly favored the black-box warning.During consideration of the proposed labeling change, the committee heard a number of presentations summarizing evidence that suicidality in children and adolescents may be increased by the newer antidepressant . . .
Tissue factor promoter polymorphism as a prognostic factor in patients with metastatic colon cancer
Authors: D. Yang, A. M. Schultheis, G. Lurje, S. Iqbal, H. Chang, W. Zhang, S. Groshen, M. Gordon, F. Nagashima, H. Lenz
Journal: Journal of Clinical Oncology (2007)

4108 Background: Tissue Factor (TF), a transmembrane glycoprotein, initiates the physiologic coagulation cascade. Cumulative evidence implies that TF plays a key role in tumor angiogenesis. Elevated TF expression has been reported to be associated with poor survival in patients in solid tumor. We investigated whether a functional TF promoter polymorphism -603 A/G is a prognostic factor in patients with advanced colon cancer because the G allele had been linked to high constitutive TF gene expression in human monocytes in healthy volunteers. Methods: 318 patients with metastatic colon cancer treated at the USC/Norris Comprehensive Cancer Center or the LA County/USC Medical Center during 1992 through 2003 were included in this study. Genomic DNA was extracted from white blood cells of peripheral blood samples using the QiaAmp kit (Qiagen, Valencia, CA). The TF polymorphism was genotyped by PCR-RFLP-based approach. The association between the TF polymorphism and overall survival was examined using the log-rank and trend test. The association between TF polymorphism and baseline demographic characteristics was tested using the χ 2 test or Fisher’s exact test when appropriate. Results: There were 141 females and 177 males, with a median age of 58 years (range 25–86). The cohort comprised 234 whites, 43 Asians, 15 Blacks, 24 Hispanics, and 2 Native Americans. The median survival was 13.7 months with a median follow-up of 2.3 years. Asians were less likely to bear the G allele compared to other racial groups (P &lt; 0.001, Fisher’s exact test). Patients who carried 1 or 2 G alleles were at higher risk of poor survival compared to patients with no G alleles (A/A) (P = 0.038, trend test). The median overall survival was 14.7 vs. 11.9 months for patients with A/A vs. patients with G/G or A/G, respectively. Conclusions: This study suggests that TF may be a prognostic factor for patients with metastatic colon cancer. The finding should be validated with future prospective clinical studies. No significant financial relationships to disclose.
Azacitidine (AZA) Versus Conventional Care Regimens (CCR) in Older Patients with Newly Diagnosed Acute Myeloid Leukemia (&gt;30% Bone Marrow Blasts) with Morphologic Dysplastic Changes: A Subgroup Analysis of the AZA-AML-001 Trial
Authors: John F Seymour, Hartmut Döhner, Aleksandra Butrym, Agnieszka Wierzbowska, Dominik Selleslag, Jun Ho Jang, James D Cavenagh, Rajat Kumar, Andre C. Schuh, Anna Candoni, Christian Récher, Irwindeep Sandhu, Teresa Bernal del Castillo, Haifa Kathrin Al-Ali, Giovanni Martinelli, Jose Falantes, Richard M Stone, Mark D. Minden, Heidi McIntyre, Stephen Songer, Lela M. Lucy, CL Beach, Hervé Dombret
Journal: Blood (2014)
Abstract 14569: Mesenchymal Stromal Cells Obtained From Patients With Critical Limb Ischemia Are Not Dysfunctional Compared to Healthy Controls
Authors: Hendrik Gremmels, Martin Teraa, Joost Fledderus, Marianne C Verhaar
Journal: Circulation (2013)

Introduction: Critical Limb Ischemia (CLI) is an advanced form of peripheral arterial disease, for which surgical treatment options are often limited. Cell therapy aimed at neovascularization using...
Abstract 16054: Cardiac Resynchronization Therapy is an Effective Therapy for Patients With Impaired Renal Function
Authors: J. Malcolm Arnold, Gary Newton, Lisa Mielniczuk, Mario Talajic, Raymond Yee, George A Wells, Anthony Tang
Journal: Circulation (2011)

Introduction: Cardiac Resynchronization Therapy (CRT) has been demonstrated to reduce mortality and hospitalization for heart failure (HF) in HF patients with left ventricular systolic dysfunction ...
P0046 : Response to loco-ablative treatment of HCC prior to liver transplantation is associated with low recurrence rates in patients exceeding the milan criteria
Authors: A. Finkenstedt, A. Vikoler, K. Mülleder, M. Portenkircher, J. Peterson, A. Luger, R. Bale, W. Vogel, S. Schneeberger, I. Graziadei, B. Glodny, H. Zoller
Journal: Journal of Hepatology (2015)
Planning for the Future in Chronic Kidney Disease
Authors: Benjamin T. Burton
Journal: Annals of Internal Medicine (1971)

Editorial Notes1 December 1971Planning for the Future in Chronic Kidney DiseaseBENJAMIN T. BURTON, PH.D.BENJAMIN T. BURTON, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-6-965 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last decade and a half, two dramatic therapies for irreversible kidney failure have come to maturity: hemodialysis with artificial kidneys and renal transplantation. Both were experimental at first and are not yet regarded as fully optimal methods, but they are probably here to stay. During 1970 in the United States approximately 1,100 new patients were placed on chronic intermittent dialysis (1) and over 900 renal transplant operations were carried out (2). Thus the clandestine experimentation in occupied Holland during World War II by Dr. Willem Kolff and the heroic surgical undertaking with twins in Boston in 1953 by...References1. National Dialysis Registry of the Artificial Kidney—Chronic Uremia Program of the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md. 20014 Google Scholar2. National Institutes of Health Organ Transplant Registry. American College of Surgeons, 55 E. Erie St., Chicago, Ill. 60611 Google Scholar3. BURTON B (editor): Kidney disease program analysis. A report to the Surgeon General. Publication No. 1745. U. S. Public Health Service, Washington, D.C., 1967 Google Scholar4. GOTTSCHALK C (editor) : Report of the Committee on Chronic Kidney Disease. A report to the Bureau of the Budget. U.S. Government Printing Office, Washington, D.C., 1967 Google Scholar5. BRANCHCLARKCOCHRANE RGA: Incidence of uraemia and requirements for maintenance haemodialysis. Br Med J 1:249-254, 1971 CrossrefMedlineGoogle Scholar6. FARROWFISHERJOHNSON SDD: Statistical approach to planning an integrated haemodialysis/transplantation programme. Br Med J 2:671-676, 1971 CrossrefMedlineGoogle Scholar7. RAPAPORT F (editor): Symposium on the current status of artificial organs for clinical transplantation. Transplantation Proc 3:in press, December 1971 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: National Institute of Arthritis and Metabolic Diseases National Institutes of Health Bethesda, Md. **The views expressed in this note are the author's own. No official support or endorsement ' by the National Institutes of Health is intended or should be inferred. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffects of triazine herbicides on the physiology of plantsProvision of services to patients with chronic uremia 1 December 1971Volume 75, Issue 6Page: 965-966KeywordsChronic kidney diseaseForecastingMedical dialysisRenal failureRenal transplantationTwins ePublished: 1 December 2008 Issue Published: 1 December 1971 PDF downloadLoading ...
Percutaneous Mitral Valve Repair for Acute Mitral Regurgitation After an Acute Myocardial Infarction
Authors: Rodrigo Estévez-Loureiro, Dabit Arzamendi, Xavier Freixa, Rosa Cardenal, Fernando Carrasco-Chinchilla, Ana Serrador-Frutos, Manuel Pan, Manel Sabaté, Jose Diaz, Jose María Hernández, Antonio Serra, Felipe Fernández-Vázquez
Journal: Journal of the American College of Cardiology (2015)
The role of angiogenesis, assessed by microvessel count (MVC), on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis.
Authors: Anne-Pascale Meert, Benoît Martin, Marianne Paesmans, Jean-Marc Verdebout, Thierry Berghmans, Jean-Jacques Lafitte, Philippe Delmotte, Céline Mascaux, Jean-Paul Sculier
Journal: European Respiratory Journal (2002)
Need for a three-focused approach to nonalcoholic fatty liver disease
Authors: Nazim A. Ghouri, David Preiss, Naveed Sattar
Journal: Hepatology (2011)

We thank Musso and colleagues for their useful comments on our article.We agree that a comprehensive approach to patients with nonalcoholic fatty liver disease, namely one which considers their diabetes and cardiovascular risk, as well as their long-term liver-related risk, is needed. We wish only to make some points of clarification which will help hepatologists to efficiently assess cardiovascular and diabetes risk in their patients. First, there have been recent calls, recently verified by the World Health Organization, to diagnose diabetes by measurement of hemoglobin A1c (HbA1c), and this measure has the advantage of being measurable on nonfasting samples.1 Of interest, HbA1c is at least as good as fasting glucose at assessing microvascular risk and appears to be the best glycemic predictor of macrovascular risk, performing even better than the 2-hour glucose tolerance test.2 We would therefore argue against routine oral glucose tolerance testing in patients with nonalcoholic fatty liver disease, because of both clinical and economical concerns. Second, the benefit of testing for insulin as a prognostic factor, we believe, remains to be proven. At present, we would advise against measuring insulin routinely, at least until this approach has been shown to be cost-effective. Third, lipid tests to enhance prediction of cardiovascular disease (as part of national cardiovascular risk guidelines or algorithms) also do not require fasting, as recently shown by the Emerging Risk Factor Collaboration group.3 Rather, nonfasting total cholesterol (or low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol) and high-density lipoprotein cholesterol adequately reflect lipid-associated vascular risk and perform as well as fasting lipids3 for risk prediction. Fasting is therefore not required to test for diabetes, or indeed cardiovascular risk, in the majority of patients. Finally, we have recently proposed4 how combined vascular and diabetes screening may be conducted by simply adding a nonfasting HbA1c test to nonfasting lipids as part of a cardiovascular risk screen, a simple process which may be easily added to other routine tests conducted in most hepatology and hepatology-related clinics. Nazim A. Ghouri M.D.*, David Preiss M.D.*, Naveed Sattar M.D.*, * British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
How to write a psychiatric consultation
Authors: T R Garrick, N L Stotland
Journal: American Journal of Psychiatry (1982)

The written psychiatric consultation is the distillation, the official permanent record, and the one universal element of the consultation process. Both the document and process present a good and growing opportunity for service and teaching. The authors offer a conceptual and practical scheme to help potential consultants make decisions about the content, style, and wording of their written communications. Each of the components of the consultation document, including headings, openings, history, examination, and formulations, is considered in terms of its effects on the liaison with the consultee and the care of the patient.
BET Bromodomain Inhibitor OTX015 Affects the Expression of Micrornas Involved in the Pathogenesis of Diffuse Large B-Cell Lymphoma
Authors: Luciano Cascione, Eugenio Gaudio, Elena Bernasconi, Chiara Tarantelli, Andrea Rinaldi, Monica Testoni, Riccardo Bomben, Valter Gattei, Ivo Kwee, Anastasios Stathis, Maria Eugenia Riveiro, Emanuele Zucca, Francesco Bertoni
Journal: Blood (2014)
Abstract 1582: Effects of Sleeping on Left Ventricular Systolic Function in Obstructive Sleep Apnea Syndrome: Quantitative Assessment Using Tissue Doppler Echocardiography
Authors: Nobuhiko Haruki, Masaaki Takeuchi, Yoshio Kanazawa, Noriko Tsubota, Rie Shintome, Roberto M Lang
Journal: Circulation (2007)
COMPARISON OF THE PATHOLOGY OF RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS
Authors: Granville A. Bennett
Journal: Annals of Internal Medicine (1943)

Article1 July 1943COMPARISON OF THE PATHOLOGY OF RHEUMATIC FEVER AND RHEUMATOID ARTHRITISGRANVILLE A. BENNETTGRANVILLE A. BENNETTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-1-111 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe present observations are based on the findings in 150 surgically treated and 48 and 101 autopsied cases of rheumatoid arthritis and rheumatic fever subjects, respectively. This material has been supplemented by numerous biopsy specimens of various lesions, particularly subcutaneous nodules.*Rheumatic Fever. Some degree of rheumatic carditis was found in all the 101 autopsied cases, and the Aschoff nodule was found in 67 instances. Of the remaining cases, 29 showed myocardial cicatrices, probably healed Aschoff nodules. Eleven patients (nine females and two males) between six and 29 years of age died with bacterial endocarditis and the hearts of four... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *The majority of these cases were studied in the Arthritis Clinic of the Massachusetts General Hospital or at the Rheumatic Clinic of the House of the Good Samaritan by Drs. Walter Bauer and T. Duckett Jones during the past 12 years. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNecrobiotic DisordersNecrobiotic DisordersDecreased Prevalence of Symptomatic Atherosclerosis in Arthritis Patients on Long-Term Aspirin TherapyThe Kidney Function in Relation to Drug Consumption in Patients with Rheumatoid Arthritis. (V)Amyloidablagerungen im periartikulären GewebeIncidence of Amyloidosis in Rheumatoid Arthritis: Some Clinical ObservationsInfluence of Rheumatoid Arthritis on Amyloidosis of AgingAmyloidoseAmyloidosis Associated with Rheumatoid ArthritisAmyloidosisThe Kidney Function in Relation to Drug Consumption in Patients with Rheumatoid Arthritis. (V)The treatment of rheumatoid arthritisThe kidney in rheumatoid arthritis: Studies by renal biopsyPsoriatic Arthritis: A Comparative Radiographic Study of Rheumatoid Arthritis and Arthritis Associated with PsoriasisRheumatism and psoriasisHeart lesions in rheumatoid diseaseRheumatoid aortitis with aortic regurgitationPSORIASIS AND ARTHRITIS.Visceral Lesions in Rheumatoid ArthritisRheumatoid Arthritis and Polyarteritis NodosaRHEUMATIC FEVER IN YOUNG ADULTSReview of the Literature on Acute Rheumatism During the Years 1939-1945Rheumatoid Arthritis: ReviewAdvances in the Study and Treatment of Rheumatoid Arthritis as Reported in 1942 and Part of 1943 1 July 1943Volume 19, Issue 1Page: 111-113KeywordsArthritisBiopsyEndocarditisHeartHospitalsLesionsMyocarditisRheumatic feverRheumatoid arthritis Issue Published: 1 July 1943 PDF downloadLoading ...
Phenotype stability in adult asthma
Authors: Roxana Mincheva, Linda Ekerljung, Anders Bjerg, Bo Lundbäck, Jan Lötvall
Journal: European Respiratory Journal (2014)

Background  Asthma comprises of several phenotypes which are still not well defined. Little is known about change over time of clinically important characteristics of asthma.   Aim  To study stability of clinical characteristics in a randomly selected adult asthma cohort.   Method : From a population study, 744 subjects with current asthma were identified by detailed clinical examinations. Of them, 64 randomly selected asthmatics were re-evaluated with identical methods. Mean follow-up time was 3.5y (SD 1.0). Mean age at follow up was 46y (SD 18).   Results  Asthma medications were used by 59 subjects at both visits, and altogether 61 used medications at follow-up. ICS (alone or in combination) were used by 42 at the first visit, 5 of whom discontinued, and in all 44 used ICS at the follow-up. Wheeze in the last 12 months was initially reported by 51, 7 of whom ceased to complain, and in all 48 reported wheeze at follow-up. The repeatability of attacks of shortness of breath, allergic rhinitis and ACT-scores was high, as well as the proportion of those with post bronchodilator FEV1/FVC    Conclusion  Clinical characteristics remained stable over 3-4 years in this well-defined asthma cohort, except for FEV1 and variability in symptoms of bronchitis. These preliminary data suggest relative stability of asthma phenotype characteristics in adults.
Abstract 18031: Effects of Rapid Intravenous Ice-Cold Fluids for Patients Treated with Therapeutic Hypothermia
Authors: Masakazu Matsuzaki, Ken Nagao, Taketomo Soga, Hiroshi Nonogi, Hiroyuki Yokoyama, Naohiro Yonemoto
Journal: Circulation (2011)

BACKGROUND Animal data has demonstrated that the sooner cooling is initiated after return of spontaneous circulation (ROSC) from cardiac arrest (CA), the better the outcome. Although rapid infusion of ice-cold intravenous (IV) fluids is feasible, safe, and simple method for induction of hypothermia, it is unclear whether technique of ice-cold IV fluids for induction of hypothermia can increase neurological benefit in patients with ROSC after out-of-hospital CA due to shockable rhythm and non-shockable rhythm. METHODS The J-PULSE-Hypo was conducted a multi-center observational registry to investigate the effects of therapeutic hypothermia. In this study, we investigated the effects of ice-cold IV fluids in patients divided into initial CA rhythm (shockable rhythm and non-shockable rhythm). The primary endpoint was favorable neurological outcome at hospital discharge. RESULTS Of the 452 unconscious adult patients who were treated with therapeutic hypothermia after out-of-hospital CA due to cardiac etiology, 435 who were cooled from 32°C to 34°C using external devices or extracorporeal devices were included; 228 received induction of cooling using rapid infusion of ice-cold IV fluids, including 185 shockable CA and 43 non-shockable CA, and 215 did not receive ice-cold IV fluids, including 156 shockable CA and 59 non-shockable CA. The time interval from ROSC to induction of cooling was shorter in the IV group than in the non-IV group in each CA rhythm (median; 28 minutes vs. 133 minutes in the shockable CA, p&lt;0.0001, 21 minutes vs. 81 min in the non-shockable CA, p&lt;0.0001). The IV group had higher frequency of favorable neurological outcome than the non-IV group in the patients with shockable CA (68.6% vs.57.7%, p=0.036), but the two groups had similar frequency of favorable neurological outcome in the patients with non-shockable CA. Adjusted odds ratios for favorable neurological outcome after the IV group was 1.66 (95% CI, 1.04-2.65) in the patients with shockable CA, and 0.53 (95% CI, 0.20-1.40) in the patients with non-shockable CA. CONCLUSION Rapid infusion of ice-cold IV fluids for induction of hypothermia had neurological benefit for patients with shockable CA, but it had not neurological benefit for patients with non-shockable CA.