THE TREATMENT OF THE LYMPHOMAS AND OTHER NEOPLASTIC DISEASES WITH NITROGEN MUSTARD
Authors: Louis K. Alpert, Ezra M. Greenspan, Stanley S. Peterson
Journal: Annals of Internal Medicine (1950)

Article1 March 1950THE TREATMENT OF THE LYMPHOMAS AND OTHER NEOPLASTIC DISEASES WITH NITROGEN MUSTARDLOUIS K. ALPERT, M.D., F.A.C.P., EZRA M. GREENSPAN, M.D., STANLEY S. PETERSON, M.D.LOUIS K. ALPERT, M.D., F.A.C.P.Search for more papers by this author, EZRA M. GREENSPAN, M.D.Search for more papers by this author, STANLEY S. PETERSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-3-393 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe beta-chloroethyl amines, or nitrogen mustards, have been used since 19421-7in the treatment of lymphomas as well as a variety of miscellaneous malignancies. It appears that, although no malignancy has been eradicated by the use of these chemical agents, some degree of temporary control has been effected in the clinical course of patients with Hodgkin's disease, the lymphosarcomas, chronic leukemias, polycythemia vera, transitional cell carcinomas, and in certain undifferentiated carcinomas of the lung and testis. Remissions in symptoms and reduction in size of tumor masses have been achieved in a significant proportion of the patients with these diseases. However,...Bibliography1. Rhoads CP: Nitrogen mustards in the treatment of neoplastic disease, J. A. M. A. 131: 656-658, 1946. CrossrefMedlineGoogle Scholar2. GoodmanWintrobeDameshekGoodmanGilmanMcLennan LSMMWMJAMT: Nitrogen mustard therapy, J. A. M. A. 132: 126-132, 1946. CrossrefMedlineGoogle Scholar3. JacobsonSpurrBarronSmithLusbaughDick LDCLESTCGF: Nitrogen mustard therapy, J. A. M. A., 132: 263-271, 1946. CrossrefMedlineGoogle Scholar4. AlpertPeterson LKSS: The use of nitrogen mustard in the treatment of lymphomata, Bull. U. S. Army M. Dept. 7: 187-194, 1947. MedlineGoogle Scholar5. Taffel M: Experiences in the treatment of neoplastic disease with nitrogen mustard, Yale J. Biol. and Med. 19: 971-977, 1947. MedlineGoogle Scholar6. WintrobeHuguleyMcLennanLima MMCMMTLP: Nitrogen mustard as a therapeutic agent for Hodgkin's disease, lymphosarcoma, and leukemia, Ann. Int. Med. 27: 529-540, 1947. LinkGoogle Scholar7. OsborneJordanHoakPschierer EDJWFCFJ: Nitrogen mustard therapy in cutaneous blastomatous disease, J. A. M. A. 135: 1125-1128, 1947. Google Scholar8. GilmanPhilips AFS: The biological actions and therapeutic applications of the beta-chloroethyl amines and sulfides, Science 103: 409-415, 1946. CrossrefGoogle Scholar9. KarnofskyBurchenalOrmsbeeCormanRhoads DAJJRAICP: Experimental observations on the use of the nitrogen mustards in the treatment of neoplastic disease, Approaches to Tumor Chemotherapy, Am. A. Adv. Sc. 294-305, 1947. Google Scholar10. AuerbachRobsonKarr CJMJG: The chemical production of mutations, Science 105: 243-247, 1947. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 8, 1948.From the Medical Service, Walter Reed General Hospital, Washington, D. C. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Nitrogen MustardsDer heutige Stand der Chemotherapie neoplastischer Erkrankungen beim MenschenThe palliative care of inoperable and incurable recrudescent neoplasmsTherapy of the malignant lymphomasZytostatikaZytostatikaClinical studies on anticancer agents from 1949 to 1951Das großfollikuläre Lymphoblastom (die Brill-Symmerssche Krankheit)Some Aspects of the Clinical Use of Nitrogen MustardsNitrogen mustard as a therapeutic agent 1 March 1950Volume 32, Issue 3Page: 393-432KeywordsCarcinomaHodgkin lymphomaLeukemiaLungsLymphomaMedical servicesPolycythemia vera ePublished: 1 December 2008 Issue Published: 1 March 1950 Copyright & PermissionsCopyright, 1950, by The American College of PhysiciansPDF downloadLoading ...