tbuckley/cabot-search huggingface dataset:
THE LETHAL EFFECTS OF SOLAR RADIATION ON GUINEA PIGS
Authors: Max Pinner, Aaron E. Margulis
Journal: Annals of Internal Medicine (1936)

Article1 August 1936THE LETHAL EFFECTS OF SOLAR RADIATION ON GUINEA PIGSMAX PINNER, M.D., F.A.C.P., AARON E. MARGULIS, M.D.MAX PINNER, M.D., F.A.C.P.Search for more papers by this author, AARON E. MARGULIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-2-214 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last 15 years, a few reports have appeared in the literature in which it was stated that mammals, and particularly rodents, died sometimes when exposed to solar radiation for relatively short periods of time. That radiant energy in certain parts of the spectrum may be lethal for photosensitized animals is well known; but it is interesting to note that several authors were surprised when they observed the lethality of solar insolation for nonsensitized animals. The hitherto published work is based on essentially qualitative studies; none satisfied even elementary physical considerations. There are no adequate measurements of the power... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Detroit meeting of the American College of Physicians, March 6, 1936.From the Laboratories of the Desert Sanatorium and Institute of Research, Tucson, Arizona.†The term power is used in this paper in its correct physical sense, meaning "rate of flow of energy; i.e. Power = Energy/Time." PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe general adaptation syndrome and the diseases of adaptation 1 August 1936Volume 10, Issue 2Page: 214-221KeywordsGuinea pigsQualitative studies ePublished: 1 December 2008 Issue Published: 1 August 1936 PDF downloadLoading ...
Abstract 14309: Left Atrial Volume and Function Indices: Trends With Age and Gender
Authors: Liza Thomas, Katrina K Poppe, Iana Simova, John J McMurray, Sherif F Nagueh, FD Richard Hobbs, Luigi P Badano, Rob N Doughty, Henrik Schirmer, Hyung-Kwan Kim, Gillian A Whalley
Journal: Circulation (2013)
Abstract 3373: MRP-8/14 is Critical for the Biological Response to Vascular Injury
Authors: Kevin Croce, Huiyun Gao, Yunmei Wang, Masashi Sakuma, Toshifumi Mooroka, Can Shi, Galina Sukhova, René R Packard, Nancy Hogg, Peter Libby, Daniel I Simon
Journal: Circulation (2008)

Background : MRP-8 (S100A8) and MRP-14 (S100A9) are members of the S100-family of calcium-modulated proteins that regulate myeloid cell function and control inflammation, in part, through activation of toll-like receptor-4 and RAGE. Using a transcriptional profiling approach in patients with acute coronary syndromes, we made the novel discovery that MRP-14 is associated with atherothrombosis, and demonstrated that elevated plasma levels of MRP-8/14 heterodimer predict increased risk of first and recurrent cardiovascular events. Despite functioning as a pro-inflammatory mediator, the role of MRP-8/14 in vascular inflammation and disease are unknown. Methods and Results : We evaluated vascular inflammation in wild-type (WT) and MRP-14-deficient (MRP-14 −/− ) mice that lack MRP-8/14 complexes with experimental arterial injury, vasculitis, or atherosclerosis. After femoral artery wire injury, MRP-14 −/− mice had a 33% reduction in leukocyte accumulation ( P =.0004) and a 72% reduction in cellular proliferation ( P =0.001) in the arterial wall followed by a 45% reduction in neointima formation ( P =0.004) compared to WT mice. In a cytokine-induced local Schwartzman-like reaction that produces thrombohemorrhagic vasculitis, MRP-14 −/− mice had a 59% reduction in lesion severity ( P &lt;0.0001), an 82% smaller hemorrhagic area ( P =0.015), and a 45% decline in neutrophil accumulation ( P =0.013). Finally, in response to high-fat feeding, mice doubly deficient in ApoE and MRP-8/14 complexes had attenuation in atherosclerotic lesion area by 34% ( P =0.023) and a 60% decrease in macrophage accumulation in plaques ( P =0.021) compared to mice deficient in ApoE alone. Conclusions: This study demonstrates that MRP-8/14 broadly regulates vascular inflammation and contributes to the biological response to vascular injury. Targeting MRP-8/14 may provide a novel therapeutic approach to modulate diverse forms of vascular injury, including restenosis, vasculitis, and atherosclerosis.
On the structural ambiguity in natural language that the neural architecture cannot deal with
Authors: Rens Bod, Hartmut Fitz, Willem Zuidema
Journal: Behavioral and Brain Sciences (2006)

We argue that van der Velde's &amp; de Kamps's model does not solve the binding problem but merely shifts the burden of constructing appropriate neural representations of sentence structure to unexplained preprocessing of the linguistic input. As a consequence, their model is not able to explain how various neural representations can be assigned to sentences that are structurally ambiguous.
Abstract 15205: Reactive Oxygen Metabolites Are Elevated in Relation to Severity of Heart Failure and Predict Cardiovascular Events in Heart Failure with Reduced Ejection Fraction
Authors: Takanori Tokitsu, Eiichiro Yamamoto, Yoshihiro Hirata, Koichiro Fujisue, Koichi Sugamura, Megumi Yamamuro, Koichi Kaikita, Seiji Hokimoto, Seigo Sugiyama, Hisao Ogawa
Journal: Circulation (2014)

Background: Reactive oxygen species (ROS) is known to contribute to the development of left ventricular (LV) dysfunction in patients with heart failure (HF). Derivative of reactive oxygen metabolites (DROM), reflecting blood hydroperoxide levels, is a new and easier-to-assay marker of ROS. We investigated the role of DROM in patients with HF with reduced LV ejection fraction (HFrEF).

Methods: (1) We enrolled consecutive 142 HFrEF patients admitted Kumamoto University Hospital and measured serum DROM levels at the stable condition after standard therapy. We classified HFrEF patients by New York Heart Association (NYHA) functional class for evaluation of the severity of HF. HFrEF patients were prospectively followed until occurrence of cardiovascular events (CVE). (2) To investigate whether serum DROM levels are associated with DROM produced in coronary circulation, we measured at the aortic root and the coronary sinus in HFrEF patients.

Results: (1) DROM values were significantly higher in HFREF patients (n=142) compared to risk-matched control subjects (n=81) (366.7±81.6 U.CARR vs 320.3±51.8 U.CARR, p 348U.CARR; median value in HFrEF patients) than in low-DROM group (log-rank test, P<0.01). (2) DROM levels at the coronary sinus were significantly higher than those at the aortic root in HFrEF patients, but not different in non-HF patients (p=0.037). The data indicated that ROS are produced in the coronary circulation in HFrEF patients.

Conclusion: Serum DROM levels associated with their production in coronary circulation, were significantly elevated in relation to severity of HF and could predict future CVE in HFrEF patients. DROM may provide clinical benefits for risk stratification in HFrEF patients.
Abstract 2975: Prognosis of Left Ventricular Hypertrabeculation/Noncompaction
Authors: Claudia Stoellberger, Maria Winkler-Dworak, Gerhard Blazek, Josef Finsterer
Journal: Circulation (2006)

Background and objectives:  Left ventricular hypertrabeculation/noncompaction (LVHT) is a cardiac abnormality frequently associated with neuromuscular disorders (NMD). From initial case reports, LVHT is assumed to have a poor prognosis. Aim of the study in a cohort of LVHT patients was to assess the long-term prognosis regarding mortality, cardiac and neuromuscular comorbidity and progression of cardiac and neuromuscular disease.   Methods and results:  In 86 patients LVHT was diagnosed echocardiographically between June 1995 and December 2004 (21 female, mean age 52 ± 14, range 14 - 94 years). All patients underwent a baseline cardiologic investigation and were invited for a neurologic investigation. A specific NMD was diagnosed in 21, a NMD of unknown etiology in 33, the neurologic investigation was normal in 13 and 19 patients refused. During a mean follow-up of 51 months (range 3 - 106 months) the mortality rate was 5.3%/year. Predictors for an increased mortality were increased age (p= 0.0134), presence of NMD (p = 0.0324), exertional dyspnoea (p = 0.0329), edema (p = 0.0049), heart failure (p = 0.0048), left anterior hemiblock (p = 0.0078) and a left ventricular fractional shortening    Conclusion:  The mortality of LVHT in adult patients is lower than previously thought. Predictors for mortality are increased age, neuromuscular disorder, heart failure, left ventricular dilatation and systolic dysfunction.
B_12- Binding Protein
Authors: VICTOR HERBERT
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 November 1971B12- Binding ProteinVICTOR HERBERT, M.D.VICTOR HERBERT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-5-808_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In his excellent review "Vitamin B12-Binding Proteins of Man" (ANNALS 75:297-301, 1971), Dr. Hall discussed "Vitamin B12 binders useful in diagnosis." Your readers should perhaps be made aware that evidence exists that a significant portion of B12-binding protein derives from leukocytes (1-3), and it is probably for this reason that measurement of vitamin B12-binding protein is of diagnostic value in assessing the existence of myeloproliferative disorders and their response to therapy.Vitamin B12-binding protein seems to correlate with the total blood granulocyte pool (3), and measures said pool rather than measuring the existence of a hematologic malignancy....References1. SIMONSWEBER KT: The vitamin B12 binding protein in human leukocytes. Biochim Biophys Acta 117:201-208, 1966 CrossrefMedlineGoogle Scholar2. CORCINOKRAUSSWAXMAN JSS: Release of vitamin B12 binding protein by human leukocytes in vitro. J Clin Invest 49:2250-2255, 1970 CrossrefMedlineGoogle Scholar3. CHIKKAPPACORCINOGREENBERG GJM: Correlation between various blood white cell pools and the serum B12-binding capacities. Blood 37:142-151, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Hospital Bronx, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1971Volume 75, Issue 5Page: 808-809KeywordsBloodGranulocytesHematologic malignanciesMyeloproliferative disordersProteins Issue Published: 1 November 1971 PDF downloadLoading ...
Abstract 17134: The Impact of Stent Diameter on Late Clinical Outcome in 734 Patients Treated by Percutaneous Coronary Intervention with Drug-Eluting Stent for Unprotected Left Main Coronary Artery Disease
Authors: Jerome Van Rothem, Julien Rosencher, Bruno Farah, Thibault Lhermusier, Nicolas Boudou, Nicolas Dumonteil, Jean Fajadet, Didier Carrie
Journal: Circulation (2012)

Objectives To evaluate whether stent diameter has long-term prognostic implications in patients undergoing drug-eluting stent (DES) supported percutaneous coronary intervention (PCI) for Unprotecte...
Pre-treatment genetic variability of NS5A region on patients infected with HCV genotype 1
Authors: Ana Carolina G. Jordim, Lilian Hiromi T. Yamasaki, Artur Trancoso L. Queiroz, Cintia Bittar, Joao R. Pinho, Claudio Marcia A. Carareto, Paula Rahal, Isabel Maria V. Mello
Journal: Hepatology (2008)
A Consideration of Natural and Acquired Body Resistance to Neoplasia
Authors: J. L. Goforth
Journal: Annals of Internal Medicine (1928)

Article1 September 1928A Consideration of Natural and Acquired Body Resistance to NeoplasiaJ. L. GOFORTH, M.D.J. L. GOFORTH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-3-275 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite extensive investigation and experimentation in practically every possible line of study in the field of neoplasia, so little has been learned that the cancer situation still confronts the medical profession as a baffling and largely unsolved problem. It has not been demonstrated that the body tissues can develop immunity to neoplasia, either naturally or artificially, and until the causes and more of the nature of the disease are determined, immunology probably will be of little aid in combating it. The body tissues, however, do build a type of resistance of greater or lesser degree, to neoplasia in the majority...References(1) STRAUSS O: Spontaneous healing of malignant tumors. Ztschr. f. Krebsforsch., 24:367, 1927. (Abstract: Arch. Path. & Lab. Med., 4:472, Sept., 1927). Google Scholar(2) KRUMBHAAR EB: The incidence and nature of splenic neoplasms, Ann. Clin. Med., 5:833, March, 1927. Google Scholar(3) JAFFÉ RH: The reticulo-endothelial system. Its rôle in pathologic conditions in man. Arch. Path. and Lab. Med., 4:45, July, 1927. Google Scholar(4) GOFORTHSNOKE JLPO: A consideration of body resistance to neoplasia, with report of a case of carcinoma of the cervix of long duration and with distant metastases. Am. J. Med. Sci., 175:504, April, 1928. CrossrefGoogle Scholar(5) SCHOCH EO: Local eosinophilia in cancer. Zentralblatt f. Gynec., Leipzig, 50:2895, Nov. 6, 1926. (Abstract: Jour. Am. Med. Ass'n., 88:-447, Feb. 5, 1927). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dallas, Texas*Read before the 12th Annual Clinical Session of the American College of Physicians at New Orleans, La., March 9, 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWeiterer Ausbau der Gasbehandlung bösartiger Geschwülste 1 September 1928Volume 2, Issue 3Page: 275-280KeywordsImmunityImmunology ePublished: 1 December 2008 Issue Published: 1 September 1928 PDF downloadLoading ...
Sudden Death after Intravenous Bismuth
Authors: L. Goodman
Journal: BMJ (1948)

considerable advantage under carefully controlled conditions such as the measurement of radiation flux with the thermoradiometer and of skin temperature.In similar fashion, tolerance limits for various pathological conditions in which the tolerance is likely to be reduced (peripheral vascular disorders, nerve lesions, large avascular scars) could be defined, and appropriate conditions established (including dosage in measured quantitative units) for radiant-heat therapy in a wide variety of diseases. Summary'rhe tolerance limit to local irradiation by visible and infrared rays has been measured in terms of radiation flux and skin temperature in 40 experimental volunteers.There is a sharp and well-defined transition from a feeling of heat which is comfortable to a sensation of burning.The skin temperature at which this change of sensation takes place is about 450 C. (1130 F.) and the tolerated radiation is of the order of 2.5 gramme-calories per square centimetre per minute.This figure is well above the usu,al therapeutic intensity, and we suggest that under well-defined conditions considerably higher intensities of radiant heat can be applied clinically than has been customary so far.We should like to thank Prof. L. J. Witts for his suggestions and advice in all phases of this work.We are much indebted to Miss MacDonald, of the Dorset House School of Occupational Therapy, and to the students at the school who were such willing volunteers.Mrs.
Drug Points: Pustular eruptions after chlorpromazine
Authors: N P Burrows, R C Ratnavel, a. P G Norris
Journal: BMJ (1994)

We report on two patients who developed pustular eruptions after treatment with chlorpromazine.

A 32 year old white man with the Eaton-Lambert syndrome and a longstanding history of obsessive compulsive disorder with unipolar depression was prescribed chlorpromazine (250 mg daily) for an acute psychotic episode. The dose was increased to 700 mg over the next 10 days. Three weeks later he developed a fever (38.5°C) and a macular eruption on his trunk, which was itchy and erythematous. The rash spread to his limbs and …
THE SIGNIFICANCE OF CLINICAL RESEARCH
Authors: Charles A. Doan
Journal: Annals of Internal Medicine (1940)

Editorial1 December 1940THE SIGNIFICANCE OF CLINICAL RESEARCHCHARLES A. DOANCHARLES A. DOANSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-6-1089 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical research may be said to represent the reconnaisance or intelligence arm of the medical profession. It is the most arduous, most hazardous (to reputation, if not to life), the slowest and most uncertain as to reward, and the most exacting of all scientific disciplines, bar none. It demands the highest integrity of its devotees, implying exact observation accurately reported. It involves an appreciation of the fact that any immediate interpretation of any isolated phenomenon is likely to be in error; and furthermore, that the facts so carefully and laboriously gathered and meticulously analyzed often serve others better as stepping... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *From the Presidential Address to the Central Society for Clinical Research, Chicago, Ill., November 4, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1940Volume 14, Issue 6Page: 1089-1091KeywordsIntelligence Issue Published: 1 December 1940 PDF downloadLoading ...
Abstract 12608: Bone Marrow Stromal Cell Derived Exosomes Carrying Microrna-486 Attenuate H/r-Induced Cardiac Myocyte Damage In Vitro and I/r-Induced Myocardial Injury In Vivo
Authors: Xiaohui Wang, Tuanzhu Ha, Xia Zhang, Chen Lu, Li Liu, Race Kao, John Kalbfleisch, David Williams, Chuanfu Li
Journal: Circulation (2014)

We have reported that Toll-like receptor 4 deficiency (TLR4 -/- ) or the TLR2 ligand, Pam3CSK4, induces protection against myocardial ischemia/reperfusion (I/R) injury. We found that the levels of myocardial microRNA-486 (miR-486) in TLR4 -/-  mice or Pam3CSK4-treated mice were significantly greater than in control groups.We hypothesized that miR-486 protects cardiac myocytes from hypoxia/reoxygenation (H/R) induced damage  in vitro  and myocardial I/R injury  in vivo . First, we treated mice with Pam3CSK4 in sham and I/R mice and examined microRNA-486 levels in serum exosomes. Second, we transfected bone marrow stromal cells (BMSCs) with miR-486 mimics and isolated exosomes carrying miR-486 (miR-486/exosomes) from BMSCs. We examined the effects of miR-486/exosomes on H/R-induced adult cardiac myocyte damage  in vitro  and on myocardial I/R injury  in vivo . Pam3CSK4 treatment significantly increases the miR-486 levels in serum exosomes of sham and I/R mice (n=4/group) and in exosomes derived from BMSCs. Transfection of adult cardiac myocytes with miR-486/exosomes markedly suppressed PTEN expression, and increased Akt phosphorylation (n=3/group). Transfection of H9C2 cardiomyoblasts with lentivirus expressing miR-486 significantly attenuated H/R-induced LDH release, increased cell viability and prevented H/R-induced caspase-3/7 and caspase-8 activities (n=6/group). Transfection of the myocardium with miR-486/exosomes immediately before the hearts were subjected to ischemia (45 min) followed by reperfusion (4 h) significantly reduced infarct size by 58% compared with the I/R control group (n=6/group). Scrambled miR/exosomes did not affect I/R-induced myocardial infarction (n=6). Transfection of miR-486, in FDA-approved nanoparticles, significantly improved cardiac function at 3 and 7 days after reperfusion (n=6). Western blot showed that transfection with miR-486/exosomes suppressed PTEN expression and increased Akt phosphorylation in the myocardium compared with I/R control (n=4/group). We conclude that miR-486 protects against H/R-induced cell damage and myocardial I/R injury via activation of PI3K/Akt signaling by targeting PTEN. Exosomes may be an attractive vehicle for carrying miRs in clinical application.
Not Available
Authors: Harriet S. Meyer
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guidelines of care for the management of atopic dermatitis
Authors: Robert Sidbury, Wynnis L. Tom, James N. Bergman, Kevin D. Cooper, Robert A. Silverman, Timothy G. Berger, Sarah L. Chamlin, David E. Cohen, Kelly M. Cordoro, Dawn M. Davis, Steven R. Feldman, Jon M. Hanifin, Alfons Krol, David J. Margolis, Amy S. Paller, Kathryn Schwarzenberger, Eric L. Simpson, Hywel C. Williams, Craig A. Elmets, Julie Block, Christopher G. Harrod, Wendy Smith Begolka, Lawrence F. Eichenfield
Journal: Journal of the American Academy of Dermatology (2014)
Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1
Authors: Irene M. Pedersen, Shinichi Kitada, Lorenzo M. Leoni, Juan M. Zapata, James G. Karras, Nobuhiro Tsukada, Thomas J. Kipps, Yong Sung Choi, Frank Bennett, John C. Reed
Journal: Blood (2002)