tbuckley/cabot-search huggingface dataset:
A commentary on “Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target Mendelian randomization and clinical trials” (Int J Surg. 2024 May 3.)
Authors: Guolin Zhang, Zhen Wang, Hanlin Yu, Xiangzhe Liu
Journal: International Journal of Surgery (2024)

aDepartment of Cardiology, The Second Hospital of Dalian Medical University, Dalian 116021, Liaoning, China bDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China cDepartment of Encephalology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China Guolin Zhang, MD, Zhen Wang These authors have contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: [email protected] (H. Yu). *Corresponding author. Address: [email protected] (X. Liu). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0/
A commentary on “Efficacy of surgical intervention over conservative management in intertrochanteric fractures among nonagenarians and centenarians: a prospective cohort study”
Authors: Tongfu Luo, Musen Zhong, Ying Zhang, Zhongcheng An
Journal: International Journal of Surgery (2024)

aTongxiang Second People's Hospital, Tongxiang, Zhejiang, People's Republic of China bThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China cThe Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: The Second Affiliated Hospital of Zhejiang Chinese Medical University, 318 Chaowang Road, Gongshu District, Hangzhou, Zhejiang 310005, People's Republic of China. E-mail address: [email protected] (Z. An). This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0/
Letter to editor:“the predictive role of hematological inflammatory markers on the prognosis of kidney injury”
Authors: Yanfei Yang, Yongquan Gao, Yuhang Liu, Guang Tan
Journal: International Journal of Surgery (2024)

aDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China bDepartment of Urinary Surgery , The First Affiliated Hospital of Dalian Medical, University, Dalian 116000, China Yanfei Yang, Yongquan Gao and Yuhang Liu: These authors have contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: E-mail address: [email protected] (Y. Yang). This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0/
Comment on: The efficacy and safety of hydrotherapy in patients with knee osteoarthritis: A meta-analysis of randomized controlled trials
Authors: Zhihu Zhao, Wei Luo, Jianxong Ma, Xinlong Ma
Journal: International Journal of Surgery (2024)

aDepartment of Orthopaedics, Tianjin Hospital, No. 406, Jiefangnan Road, Hexi District, Tianjin, 300211, China bTianjin Institute of Orthopedics in Traditional Chinese and Western Medicine, No. 122, Munan Road, Tianjin, 300050, China Zhihu Zhao and Wei Luo contributed equally to this article and should be listed as co-first authors. The original contributions proposed in the study are included in these paper/supplementary materials. Please contact the corresponding author directly for further inquiry. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Orthopaedics, Tianjin Hospital, No. 406, Jiefangnan Road, Hexi District, Tianjin, 300000, China. E-mail address: [email protected] (X. Ma). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0/
A commentary on “barriers and facilitators to sustainable operating theatres: a systematic review using the Theoretical Domains Framework”
Authors: Xue Li, Xiaorui Xie
Journal: International Journal of Surgery (2024)

Department of Anesthesiology, Aerospace Central Hospital, Beijing 100049, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Anesthesiology, Aerospace Central Hospital, Beijing 100049, China. E-mail address: [email protected] (X. Li). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Nomogram for predicting intolerable postoperative early enteral nutrition following definitive surgery for small intestinal fistula: a cohort study
Authors: Weiliang Tian, Lei Luo, Xin Xu, Risheng Zhao, Tao Tian, Wuhan Li, Yunzhao Zhao, Zheng Yao
Journal: International Journal of Surgery (2024)

Background: This study was designed to develop and validate a nomogram for predicting intolerable early enteral nutrition (EEN) following definitive surgery (DS) for small intestinal fistula. Methods: A total of 377 patients, recruited from January 2016 to September 2023, was randomly allocated into development ( n =251) and validation ( n =126) groups in a 2:1 ratio. Risk factors were identified using the nomogram. Its performance was assessed based on calibration, discrimination, and clinical utility, with validation confirming its effectiveness. Results: Of the 377 patients, 87 (23.1%) were intolerant to EEN, including 59 (23.1%) in the development cohort and 28 (22.1%) in the validation cohort ( P =0.84). Four factors were identified as predictive of intolerable EEN: severe abdominal adhesion, deciliter of blood loss during DS, human serum albumin (Alb) input &gt;40 g during and within 48 h post-DS, and the visceral fat area (VFA)/total abdominal muscle area index (TAMAI) ratio. The model demonstrated excellent discrimination, with a C-index of 0.79 (95% CI: 0.74–0.87, including internal validation) and robust calibration. In the validation cohort, the nomogram showed strong discrimination (C-index=0.77; 95% CI: 0.64–0.87) and solid calibration. Decision curve analysis affirmed the nomogram’s clinical utility. Conclusion: This research introduces a nomogram that enables the individualized prediction of intolerable EEN following DS for small intestinal fistula, demonstrating a possible clinical utility.
Skin tape‐strips in old order Mennonite toddlers reveal upregulated barrier markers and low T‐helper inflammatory tone
Authors: Camille Rothenberg‐Lausell, Eden David, Ester Del Duca, Joel Correa Da Rosa, Dante Dahabreh, Pedro Jesús Gómez‐Arias, Elizabeth Catlin, Monali Nandymazumdar, Kirsi M. Järvinen, Emma Guttman‐Yassky
Journal: Allergy (2024)

The data that supports the findings of this study are available in the supplementary material of this article. Figure S1. Data S1. Table S1. Table S2. Table S3. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Correction of the cover caption and Editorial of Trends in Immunology Volume 45, Issue 5 (May 2024)
Authors: Catarina Sacristán
Journal: Trends in Immunology (2024)

The editor would like to amend these inadvertent mistakes: in the cover description statement, "Our special issue 'Neuroimmunology – I' showcases current research in this discipline, emphasizing the reciprocal interplay between the brain and our nervous systems (central or peripheral)", instead should read, "Our special issue 'Neuroimmunology – I' showcases current research in this discipline, emphasizing the reciprocal interplay between our immune and nervous systems (central or peripheral)." In the Editorial article 'Partners and guardians of the nervous and immune systems', the sentence 'We continue to marvel at the reciprocal interplay between the brain, our nervous systems (central and peripheral), and our immune system' should instead read 'We continue to marvel at the reciprocal interplay between our nervous (central and peripheral), and immune systems'.
A cuttlefish ink nanoparticle-reinforced biopolymer hydrogel with robust adhesive and immunomodulatory features for treating oral ulcers in diabetes
Authors: Yajing Xiang, Pan Zhuge, Xiaoliang Qi, XinXin Ge, Junbo Xiang, Hangbin Xu, Erya Cai, Yulong Lan, Xiaojing Chen, Ying Li, Yizuo Shi, Jianliang Shen, Jinsong Liu
Journal: Bioactive Materials (2024)

Oral ulcers can be managed using a variety of biomaterials that deliver drugs or cytokines. However, many patients experience minimal benefits from certain medical treatments because of poor compliance, short retention times in the oral cavity, and inadequate drug efficacy. Herein, we present a novel hydrogel patch (SCE2) composed of a biopolymer matrix (featuring ultraviolet-triggered adhesion properties) loaded with cuttlefish ink nanoparticles (possessing pro-healing functions). Applying a straightforward local method initiates the formation of a hydrogel barrier that adheres to mucosal injuries under the influence of ultraviolet light. SCE2 then demonstrates exceptional capabilities for near-infrared photothermal sterilization and neutralization of reactive oxygen species. These properties contribute to the elimination of bacteria and the management of the oxidation process, thus accelerating the healing phase's progression from inflammation to proliferation. In studies involving diabetic rats with oral ulcers, the SCE2 adhesive patch significantly quickens recovery by altering the inflamed state of the injured area, facilitating rapid re-epithelialization, and fostering angiogenesis. In conclusion, this light-sensitive hydrogel patch offers a promising path to expedited wound healing, potentially transforming treatment strategies for clinical oral ulcers.
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Authors: Pawel K. Mazur, Alexander Herner, Stephano S. Mello, Matthias Wirth, Simone Hausmann, Francisco J. Sánchez-Rivera, Shane M. Lofgren, Timo Kuschma, Stephan A. Hahn, Deepak Vangala, Marija Trajkovic-Arsic, Aayush Gupta, Irina Heid, Peter B. Noël, Rickmer Braren, Mert Erkan, Jörg Kleeff, Bence Sipos, Leanne C. Sayles, Mathias Heikenwalder, Elisabeth Heßmann, Volker Ellenrieder, Irene Esposito, Tyler Jacks, James E. Bradner, Purvesh Khatri, E. Alejandro Sweet-Cordero, Laura D. Attardi, Roland M. Schmid, Guenter Schneider, Julien Sage, Jens T. Siveke
Journal: Nature Medicine (2024)

In the originally published version of this article, there were errors in the histological sections depicted in Supplementary Figs. 4 and10
Targeting a lineage-specific PI3Kɣ–Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule
Authors: Lois M. Kelly, Justine C. Rutter, Kevin H. Lin, Frank Ling, Matthieu Duchmann, Emmanuelle Latour, Nadia Arang, Hélène Pasquer, Duong Ho Nhat, Juliette Charles, Shane T. Killarney, Hazel X. Ang, Federica Namor, Cécile Culeux, Bérangère Lombard, Damarys Loew, Danielle L. Swaney, Nevan J. Krogan, Luc Brunel, Élodie Carretero, Pascal Verdié, Muriel Amblard, Sofiane Fodil, Tony Huynh, Marie Sebert, Lionel Adès, Emmanuel Raffoux, Nina Fenouille, Raphaël Itzykson, Camille Lobry, Lina Benajiba, Antoine Forget, Anthony R. Martin, Kris C. Wood, Alexandre Puissant
Journal: Nature Cancer (2024)
Advancing skeletal health and disease research with single-cell RNA sequencing
Authors: Peng Lin, Yi-Bo Gan, Jian He, Si-En Lin, Jian-Kun Xu, Liang Chang, Li-Ming Zhao, Jun Zhu, Liang Zhang, Sha Huang, Ou Hu, Ying-Bo Wang, Huai-Jian Jin, Yang-Yang Li, Pu-Lin Yan, Lin Chen, Jian-Xin Jiang, Peng Liu
Journal: Military Medical Research (2024)

Abstract Orthopedic conditions have emerged as global health concerns, impacting approximately 1.7 billion individuals worldwide. However, the limited understanding of the underlying pathological processes at the cellular and molecular level has hindered the development of comprehensive treatment options for these disorders. The advent of single-cell RNA sequencing (scRNA-seq) technology has revolutionized biomedical research by enabling detailed examination of cellular and molecular diversity. Nevertheless, investigating mechanisms at the single-cell level in highly mineralized skeletal tissue poses technical challenges. In this comprehensive review, we present a streamlined approach to obtaining high-quality single cells from skeletal tissue and provide an overview of existing scRNA-seq technologies employed in skeletal studies along with practical bioinformatic analysis pipelines. By utilizing these methodologies, crucial insights into the developmental dynamics, maintenance of homeostasis, and pathological processes involved in spine, joint, bone, muscle, and tendon disorders have been uncovered. Specifically focusing on the joint diseases of degenerative disc disease, osteoarthritis, and rheumatoid arthritis using scRNA-seq has provided novel insights and a more nuanced comprehension. These findings have paved the way for discovering novel therapeutic targets that offer potential benefits to patients suffering from diverse skeletal disorders.
Neutrophil Cathepsin G and Thrombosis in COVID-19
Authors: Francesco Violi, Simona Bartimoccia, Roberto Cangemi, Cristina Nocella, Alessandra D’Amico, Alessandra Oliva, Mario Venditti, Francesco Pugliese, Claudio Maria Mastroianni, Lorenzo Ridola, Miriam Lichtner, Vincenzo Cardinale, Domenico Alvaro, Vittoria Cammisotto, Valentina Castellani, Pasquale Pignatelli, Roberto Carnevale
Journal: Circulation Research (2024)
Lung cancer and idiopathic pulmonary fibrosis: environmental exposures are the key
Authors: Lucile Sesé, Isabella Annesi-Maesano
Journal: European Respiratory Journal (2024)

<h3>Shareable abstract</h3> <b>The study presented by H-Y. Yoon and co-workers in the <i>ERJ</i> is the first to evaluate the effect of air pollution on lung cancer risk in an IPF population</b>https://bit.ly/4b8TvTZ
Understanding evidence from randomised controlled trials and meta-analyses: a comparative overview
Authors: Mario Cazzola, Daiana Stolz, Mona Bafadhel, Paola Rogliani
Journal: European Respiratory Journal (2024)

<h3>Shareable abstract</h3> <b>RCTs and meta-analyses are two distinct yet interconnected methodologies within evidence-based research. It is important to avoid favouring one method over the other as the best source of evidence.</b> https://bit.ly/3Qi6vOR
Mechanically skin-like and water-resistant self-healing bioelastomer for high-tension wound healing
Authors: Jinyi Huang, Hongying Chen, Zenghui Jia, Xingqi Song, Sinan Wang, Baoshuai Bai, Jian Wang, Junfeng Zhang, Guangdong Zhou, Dong Lei
Journal: Bioactive Materials (2024)

The biomedical application of self-healing materials in wet or (under)water environments is quite challenging because the insulation and dissociation effects of water molecules significantly reduce the reconstruction of material-interface interactions. Rapid closure with uniform tension of high-tension wounds is often difficult, leading to further deterioration and scarring. Herein, a new type of thermosetting water-resistant self-healing bioelastomer (WRSHE) was designed by synergistically incorporating a stable polyglycerol sebacate (PGS) covalent crosslinking network and triple hybrid dynamic networks consisting of reversible disulfide metathesis (SS), and dimethylglyoxime urethane (Dou) and hydrogen bonds. And a resveratrol-loaded WRSHE (Res@WRSHE) was developed by a swelling, absorption, and crosslinked network locking strategy. WRSHEs exhibited skin-like mechanical properties in terms of nonlinear modulus behavior, biomimetic softness, high stretchability, and good elasticity, and they also achieved ultrafast and highly efficient self-healing in various liquid environments. For wound-healing applications of high-tension full-thickness skin defects, the convenient surface assembly by self-healing of WRSHEs provides uniform contraction stress to facilitate tight closure. Moreover, Res@WRSHEs gradually release resveratrol, which helps inflammatory response reduction, promotes blood vessel regeneration, and accelerates wound repair.
Empiric antibiotic regimens in adults with non-ventilator-associated hospital-acquired pneumonia: a systematic review and network meta-analysis of randomized controlled trials
Authors: Maryam Ghadimi, Reed A.C. Siemieniuk, Gordon Guyatt, Mark Loeb, Afeez Abiola Hazzan, Danial Aminaei, Huda Gomaa, Ying Wang, Liang Yao, Arnav Agarwal, John Basmaji, Alexandre Grant, William S.H. Kim, Giancarlo Alvarado-Gamarra, Valery Likhvantsev, João Pedro Lima, Shahrzad Motaghi, Rachel Couban, Behnam Sadeghirad, Romina Brignardello-Petersen
Journal: Clinical Microbiology and Infection (2024)

The optimal empiric antibiotic regimen for non-ventilator-associated hospital-acquired pneumonia (HAP) is uncertain.
A 3D Bioprinted Cortical Organoid Platform for Modeling Human Brain Development
Authors: Melissa A. Cadena, Anson Sing, Kylie Taylor, Linqi Jin, Liqun Ning, Mehdi Salar Amoli, Yamini Singh, Samantha N. Lanjewar, Martin L. Tomov, Vahid Serpooshan, Steven A. Sloan
Journal: Advanced Healthcare Materials (2024)

Abstract The ability to promote three‐dimensional (3D) self‐organization of induced pluripotent stem cells into complex tissue structures called organoids presents new opportunities for the field of developmental biology. Brain organoids have been used to investigate principles of neurodevelopment and neuropsychiatric disorders and serve as a drug screening and discovery platform. However, brain organoid cultures are currently limited by a lacking ability to precisely control their extracellular environment. Here, this work employs 3D bioprinting to generate a high‐throughput, tunable, and reproducible scaffold for controlling organoid development and patterning. Additionally, this approach supports the coculture of organoids and vascular cells in a custom architecture containing interconnected endothelialized channels. Printing fidelity and mechanical assessments confirm that fabricated scaffolds closely match intended design features and exhibit stiffness values reflective of the developing human brain. Using organoid growth, viability, cytoarchitecture, proliferation, and transcriptomic benchmarks, this work finds that organoids cultured within the bioprinted scaffold long‐term are healthy and have expected neuroectodermal differentiation. Lastly, this work confirms that the endothelial cells (ECs) in printed channel structures can migrate toward and infiltrate into the embedded organoids. This work demonstrates a tunable 3D culturing platform that can be used to create more complex and accurate models of human brain development and underlying diseases.
Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes
Authors: Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Zhiya Yu, Sivasish Sindiri, Jared J Gartner, Maria Parkhurst, Sri Krishna, Frank J Lowery, Nikolaos Zacharakis, Lior Levy, Todd D Prickett, Tiffany Benzine, Satyajit Ray, Robert V Masi, Billel Gasmi, Yong Li, Rafiqul Islam, Alakesh Bera, Stephanie L Goff, Paul F Robbins, Steven A Rosenberg
Journal: Journal for ImmunoTherapy of Cancer (2024)

Background Tumor-infiltrating lymphocytes (TILs) targeting neoantigens can effectively treat a selected set of metastatic solid cancers. However, harnessing TILs for cancer treatments remains challenging because neoantigen-reactive T cells are often rare and exhausted, and ex vivo expansion can further reduce their frequencies. This complicates the identification of neoantigen-reactive T-cell receptors (TCRs) and the development of TIL products with high reactivity for patient treatment. Methods We tested whether TILs could be in vitro stimulated against neoantigens to achieve selective expansion of neoantigen-reactive TILs. Given their prevalence, mutant p53 or RAS were studied as models of human neoantigens. An in vitro stimulation method, termed “NeoExpand”, was developed to provide neoantigen-specific stimulation to TILs. 25 consecutive patient TILs from tumors harboring p53 or RAS mutations were subjected to NeoExpand. Results We show that neoantigenic stimulation achieved selective expansion of neoantigen-reactive TILs and broadened the neoantigen-reactive CD4 + and CD8 + TIL clonal repertoire. This allowed the effective isolation of novel neoantigen-reactive TCRs. Out of the 25 consecutive TIL samples, neoantigenic stimulation enabled the identification of 16 unique reactivities and 42 TCRs, while conventional TIL expansion identified 9 reactivities and 14 TCRs. Single-cell transcriptome analysis revealed that neoantigenic stimulation increased neoantigen-reactive TILs with stem-like memory phenotypes expressing IL-7R, CD62L, and KLF2. Furthermore, neoantigenic stimulation improved the in vivo antitumor efficacy of TILs relative to the conventional OKT3-induced rapid TIL expansion in p53-mutated or KRAS-mutated xenograft mouse models. Conclusions Taken together, neoantigenic stimulation of TILs selectively expands neoantigen-reactive TILs by frequencies and by their clonal repertoire. NeoExpand led to improved phenotypes and functions of neoantigen-reactive TILs. Our data warrant its clinical evaluation. Trial registration number NCT00068003 , NCT01174121 , and NCT03412877 .
Induction-concurrent chemoradiotherapy with or without sintilimab in patients with locoregionally advanced nasopharyngeal carcinoma in China (CONTINUUM): a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial
Authors: Xu Liu, Yuan Zhang, Kun-Yu Yang, Ning Zhang, Feng Jin, Guo-Rong Zou, Xiao-Dong Zhu, Fang-Yun Xie, Xiao-Yu Liang, Wen-Fei Li, Zhen-Yu He, Nian-Yong Chen, Wei-Han Hu, Hai-Jun Wu, Mei Shi, Guan-Qun Zhou, Yan-Ping Mao, Rui Guo, Rui Sun, Jing Huang, Shao-Qiang Liang, Wei-Li Wu, Zhen Su, Ling Li, Ping Ai, Yu-Xiang He, Jian Zang, Lei Chen, Li Lin, Shao Hui Huang, Cheng Xu, Jia-Wei Lv, Ying-Qing Li, Shu-Bin Hong, Yu-Sheng Jie, Hao Li, Sai-Wei Huang, Ye-Lin Liang, Ya-Qin Wang, Ying-Lin Peng, Jin-Han Zhu, Sheng-Bing Zang, Song-Ran Liu, Qing-Guang Lin, Hao-Jiang Li, Li Tian, Li-Zhi Liu, Hong-Yun Zhao, Ai-Hua Lin, Ji-Bin Li, Na Liu, Ling-Long Tang, Yu-Pei Chen, Ying Sun, Jun Ma
Journal: The Lancet (2024)