Postoperative Sexual Function After Vaginal Surgery and Clitoral Size, Position, and Shape
Authors: Shaniel T. Bowen, Pamela A. Moalli, Rebecca G. Rogers, Marlene M. Corton, Uduak U. Andy, Charles R. Rardin, Michael E. Hahn, Alison C. Weidner, David R. Ellington, Donna Mazloomdoost, Amaanti Sridhar, Marie G. Gantz, Kimberly Ferrante, Sherella Johnson, Emily S. Lukacz, Charles W. Nager, Gouri B. Diwadkar, Keisha Y. Dyer, Linda M. Mackinnon, Jasmine Tan-Kim, Gisselle Zazueta-Damian, Cindy Amundsen, Yasmeen Bruton, Notorious Coleman-Taylor, Amie Kawasaki, Nicole Longoria, Shantae McLean, Nazema Siddiqui, Kathy Carter, Mark E. Lockhart, Sunita Patel, Holly E. Richter, Nancy Saxon, Velria B. Willis, Cassandra Carberry, Brittany S. Hampton, Nicole Korbly, Ann S. Meers, Deborah L. Myers, Vivian W. Sung, Kyle Wohlrab, Gena Dunivan, Yuko Komesu, Peter Jeppson, Lily Arya, Lorraine Flick, Heidi Harvie, Michelle Kinglee, Ariana Smith, Steven D. Abramowitch, Michael Bonidie, Judy Gruss, Jonathan Shepherd, Gary Sutkin, Halina M. Zyczynski, Matthew Barber, Annette Graham, Marie Fidela R. Paraiso, Cecile Ferrando, Kate Burdekin, Michael Ham, Amanda Shaffer, Dennis Wallace, Ryan Whitworth, Taylor Swankie
Journal: JAMA Surgery (2025)

Importance Transvaginal surgery is commonly performed to treat pelvic organ prolapse. Little research focuses on how sexual function relates to clitoral anatomy after vaginal surgery despite the clitoris’ role in the sexual response. Objective To determine how postoperative sexual function after vaginal surgery is associated with clitoral features (size, position, shape). Design, Setting, and Participants This was a cross-sectional ancillary study of magnetic resonance imaging (MRI) data from the Defining Mechanisms of Anterior Vaginal Wall Descent (DEMAND) study. The setting comprised 8 clinical sites in the US Pelvic Floor Disorders Network and included the MRI data of 88 women with uterovaginal prolapse previously randomized to either vaginal mesh hysteropexy or vaginal hysterectomy with uterosacral ligament suspension between 2013 and 2015. Data were analyzed between September 2021 and June 2023. Exposures Participants underwent postoperative pelvic MRI at 30 to 42 months (or earlier if reoperation was desired) between June 2014 and May 2018. Sexual activity and function at baseline (preoperatively) and 24- to 48-month follow-up (postoperatively) were assessed using the Pelvic Organ Prolapse/Incontinence Sexual Questionnaire, International Urogynecological Association Revised (PISQ-IR). Clitoral features were derived from postoperative MRI-based 3-dimensional models. Main Outcomes and Measures Correlations between (1) PISQ-IR mean, subscale, and item scores and (2) clitoral size, position, and shape (principal component scores). Results A total of 82 women (median [range] age, 65 [47-79] years) were analyzed (41 received hysteropexy and 41 received hysterectomy). Postoperatively, 37 were sexually active (SA), and 45 were not SA (NSA). Among SA women, better overall postoperative sexual function (higher PISQ-IR summary score) correlated with a larger clitoral glans width (Spearman ρ = 0.37; 95% CI, 0.05-0.62; P = .03) and thickness (Spearman ρ = 0.38; 95% CI, 0.06-0.63; P = .02). Among NSA women, sexual inactivity related to postoperative dyspareunia correlated with a more lateral clitoral position (Spearman ρ = 0.45; 95% CI, 0.18-0.66; P = .002), and sexual inactivity related to incontinence/prolapse correlated with a more posterior clitoral position (Spearman ρ = −0.36; 95% CI, −0.60 to −0.07; P = .02) (farther from the pubic symphysis). Shape analysis demonstrated that poorer postoperative sexual function outcomes in SA women and sexual inactivity in NSA women correlated with a more posteriorly positioned glans, anteriorly oriented clitoral body, medially positioned crura, and lateral vestibular bulbs. Conclusions and Relevance Results of this cross-sectional study suggest that postoperative sexual function after vaginal surgery was associated with clitoral glans size, position, and shape. Results warrant prospective studies on surgery-induced changes in clitoral anatomy and sexual function.