tbuckley/cabot-search huggingface dataset:
Polygenic Risk Score and Upgrading in Patients With Prostate Cancer Receiving Active Surveillance
Authors: Louisa B. Goss, Menghan Liu, Yingye Zheng, Boya Guo, David V. Conti, Christopher A. Haiman, Linda Kachuri, William J. Catalona, John S. Witte, Daniel W. Lin, Lisa F. Newcomb, Burcu F. Darst
Journal: JAMA Oncology (2024)

Importance Active surveillance is the preferred management strategy for patients with low- or favorable intermediate-risk prostate cancer (PCa); however, frequent health care visits can be costly and burdensome to patients. Identifying patients who may benefit from intensive vs passive surveillance could reduce these burdens. Objective To investigate associations between a polygenic risk score (PRS) and risk of upgrading and other prostate tumor features in patients receiving active surveillance. Design, Setting, and Participants This prospective multicenter cohort study across 10 US sites included 1220 patients from the Canary Prostate Active Surveillance Study (PASS) enrolled from July 2008 to November 2017, with follow-up (median, 5.3 years) through August 2022. Participants were those with clinically localized PCa (cT1-T2) receiving active surveillance. Analyses took place from January 2023 to April 2024. Exposure Multi-ancestry PRS of 451 PCa risk variants (PRS-451) and 400 PCa risk variants (PRS-400) after excluding prostate-specific antigen (PSA)–associated variants. Main Outcomes and Measures The primary outcome was PCa upgrading (any Gleason grade increase) vs no upgrading. Secondary outcomes included prostate volume, PSA, PSA density, percentage of biopsy cores with cancer, and Gleason grade group at diagnosis. Results The median (IQR) age at diagnosis of the 1220 patients receiving active surveillance was 63 (58-67) years. During follow-up, 470 patients upgraded; the 2- and 5-year risks of upgrading were 17.7% (95% CI, 15.5%-19.9%) and 33.3% (95% CI, 30.5%-36.3%), respectively. Each 1-SD unit increase in PRS-451 was associated with 23% increased hazard of upgrading (95% CI, 1.11-1.35; P &amp;amp;lt; .001), whereas PRS-400 was associated with 27% increased hazard (95% CI, 1.15-1.39; P &amp;amp;lt; .001) at any point in time during follow-up. Except for PSA, associations with remaining outcomes were similar or stronger using PRS-400. Higher PRS-400 was associated with smaller prostate volume, a higher percentage of biopsy cores with cancer, and higher PSA density. A model with clinical risk factors had a C-index of 0.64 (95% CI, 0.62-0.67); adding PRS-400 led to a C-index of 0.65 (95% CI, 0.63-0.68). Conclusions and Relevance In this cohort study, among patients receiving active surveillance, high PRS was associated with risk of upgrading and possibly tumor multifocality. Excluding PSA variants from the PRS revealed an association with smaller prostate size, which has been previously associated with more aggressive tumors. Although PRS may inform active surveillance, it is yet to be seen whether they improve clinical decisions.
Second Primary Cancer After Chimeric Antigen Receptor–T-Cell Therapy
Authors: Shyam A. Patel, Jay Y. Spiegel, Saurabh Dahiya
Journal: JAMA Oncology (2024)

Importance The commercialization of chimeric antigen receptor–T-cell (CAR-T) therapy has changed the landscape of treatment of hematological cancers. Numerous studies from the early 2000s paved the way for cell-based targeted therapeutics, which have been established as practice-changing therapies in lymphoma, leukemia, and multiple myeloma. However, there has been some recent concern about the risk for second primary cancers (SPCs). Observations Multiple cases of SPCs arising after CAR-T therapy have been reported to the US Food and Drug Administration. Most SPCs have been negative for the chimeric antigen receptor transgene, with rare reports of transgene-positive cancers. This review summarizes the most salient literature on epidemiology and pathobiology of SPCs after CAR-T therapy. Additionally, a discussion is provided on potential mitigation strategies for SPCs after CAR-T therapies. Conclusions and Relevance The results of this review suggest that there are limited data to suggest that inadvertent transgene insertion is associated with SPCs in the post–CAR-T setting. Nonetheless, evidence-based practical solutions and scientific strategies for risk mitigation can be implemented. These include optimization of T-cell manufacturing, application of safer synthetic immunobiology, and implementation of high-fidelity genomic testing, including baseline screening for clonal hematopoiesis. These strategies may inform optimal design of the next generation of CAR-T products that confer minimal risk for SPCs such that the risk-benefit profile remains favorable to proceed with CAR-T administration for eligible patients.
Mortality Among Severely Injured Adolescents Admitted to Pediatric vs Adult Trauma Centers
Authors: Fiona Muttalib, Bourke Tillmann, Genevieve Ernst, Srinivas Murthy, Zulfiqar Bhutta, Bettina Hansen, Neill K. J. Adhikari
Journal: JAMA Network Open (2024)

Care in a pediatric (vs adult) trauma center improves outcomes for injured children aged 0 to 12 years, but whether pediatric care benefits injured adolescents is unclear.
Oncological Safety of MRI-Informed Biopsy Decision-Making in Men With Suspected Prostate Cancer
Authors: Charlie A. Hamm, Patrick Asbach, Anna Pöhlmann, Ivo G. Schoots, Veeru Kasivisvanathan, Thomas O. Henkel, Manfred Johannsen, Thomas Speck, Alexander D. J. Baur, Matthias Haas, Federico Collettini, Tobias Penzkofer, Lynn J. Savic, Frank Konietschke, Lothar Weißbach, Bernd Hamm, Frank König, Hannes Cash
Journal: JAMA Oncology (2024)

The magnetic resonance imaging (MRI) pathway for diagnosing clinically significant prostate cancer (csPCa; defined as International Society of Urological Pathology grade group ≥2) uses multiparametric MRI (mpMRI) for prostate biopsy (PB) decision-making. However, the intermediate impact on patient outcomes in men with negative MRI results avoiding PB and men with positive MRI results without PCa remains unknown.
BNT162b2 XBB Vaccine for COVID-19 Among Children 5-17 Years of Age
Authors: Sara Y. Tartof, Timothy B. Frankland, Laura Puzniak, Jeff M. Slezak, Bradley K. Ackerson, Vennis Hong, Julie Stern, Joann M. Zamparo, Hina Chowdhry, Brigitte Spence, Gregg S. Davis, Luis Jodar, John M. McLaughlin
Journal: JAMA Network Open (2024)

This case-control study of US children examines vaccine effectiveness rates of a messenger RNA vaccine during the 2023-2024 respiratory virus season.
Nonischemic Cardiac Manifestations in VEXAS Syndrome
Authors: Marie Robert, Alexis Mathian, Valentin Lacombe, Hervé Lobbes, Léopold Adélaïde, Maelle Le Besnerais, Jean-Nicolas Dacher, Benjamin Terrier, Arsène Mékinian, Rim Bourguiba, Sophie Georgin-Lavialle, Jérome HADJADJ, Yann NGUYEN, Dalila MOULOUDJ, Mael HEIBLIG, Hassina ALOUI, Chloé MC AVOY, Samuel ARDOIS, Corrado CAMPOCHIARO, Alexandre MARIA, Cyrille COUSTAL, Thibault COMONT, Estibaliz LAZARO, François LIFERMANN, Guillaume LE GUENNO, Vincent GROBOST, Roderau OUTH, Julien CAMPAGNE, Anais DOR-ETIENNE, Alice GARNIER, Yvan JAMILLOUX, Antoine DOSSIER, Maxime SAMSON, Sylvain AUDIA, Barbara NICOLAS, Baptiste DE MALEPRADE, Benjamin DE SAINTE MARIE, Benoit FAUCHER, Jean-David BOUAZIZ, Jonathan BRONER, Cyril DUMAIN, Carole ANTOINE, Benjamin CARPENTIER, Brice CASTEL, Céline LARTIGAU-ROUSSIN, Etienne CRICKX, Geoffroy VOLLE, Damien FAYARD, Paul DECKER, Thomas MOULINET, Anael DUMONT, Alexandre NGUYEN, Achille AOUBA, Jean-Philippe MARTELLOSIO, Matthieu LEVAVASSEUR, Sébastien PUIGRENIER, Pascale ANTOINE, Jean-Thomas GIRAUD, Olivier HERMINE, Carole LACOUT, Nihal MARTIS, Jean-Denis KARAM, François CHASSET, Laurent ARNAUD, Paola MARIANETTI GUINGEL, Christophe DELIGNY, Thibaud CHAZAL, Pascal WOAYE-HUNE, Marielle ROUX-SAUVAT, Aurore MEYER, Pierre HIRSCH, Noémie ABISROR, Pierre FENAUX, Olivier KOSMIDER, Vincent JACHIER, Olivier FAIN
Journal: JAMA Network Open (2024)

This case series reports on the clinical presentation, laboratory findings, imaging characteristics, treatments, and outcomes of nonischemic cardiac manifestations in patients with VEXAS syndrome with confirmed pathogenic UBA1 alterations.
Bilateral Mastectomy vs Lumpectomy and Breast Cancer Mortality Risk
Authors: Thomas J. O’Keefe, Michael D. Alvarado, Laura J. Esserman¸
Journal: JAMA Oncology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Gestational Diabetes, the Human Milk Metabolome, and Infant Growth and Adiposity
Authors: Emily M. Nagel, Armando Peña, Jonathan M. Dreyfuss, Eric F. Lock, Kelsey E. Johnson, Chang Lu, David A. Fields, Ellen W. Demerath, Elvira Isganaitis
Journal: JAMA Network Open (2024)

Importance Gestational diabetes (GD) is linked to health risks for the birthing parent and infant. The outcomes of GD on human milk composition are mostly unknown. Objective To determine associations between GD, the human milk metabolome, and infant growth and body composition. Design, Setting, and Participants Cohort study using data from the Mothers and Infants Linked for Healthy Growth and the Maternal Milk, Metabolism, and the Microbiome studies at the University of Oklahoma and University of Minnesota, large prospective US cohorts with a high proportion of exclusive breastfeeding. Participants were mother-infant dyads recruited between October 2014 and August 2019 who planned to exclusively breastfeed for 3 or more months. Data were analyzed from July 2022 to August 2024. Exposure GD diagnosed via oral glucose tolerance test. Main Outcomes and Measures The milk metabolome was assessed by untargeted liquid chromatography–gas chromatography–mass spectrometry at 1 month post partum. Infant growth (weight for length z score, length for age z score, and rapid weight gain) and body composition (percentage body fat and fat-free mass index) from 0 to 6 months were assessed. Linear regression analyses tested associations between GD and milk metabolites, with adjustment for covariates and potential confounders. Results Among 348 dyads (53 with GD), 27 (51%) of the GD-exposed infants were female and 157 (53%) of nonexposed infants were male; 10 (19%) were Asian, 2 (4%) were Black or African American, and 37 (70%) were White. The mean (SD) age was higher in the GD group (with GD, 34.0 [4.3] years; without GD, 30.7 [4.1] years). In adjusted models, GD was associated with differential levels of 9 metabolites of 458 tested (FDR&amp;amp;lt;0.05); 3 were higher (2-hydroxybutyric acid, 3-methylphenylacetic acid, and pregnanolone sulfate) and 6 were lower in women with GD (4-cresyl sulfate, cresol, glycine, P-cresol sulfate, phenylacetic acid, and stearoylcarnitine). Phenylacetic acid was associated with length for age z score (β = 0.27; SE, 0.13; 95% CI, 0.02 to 0.16), 2-hydroxybutryic acid with percentage body fat (β = −1.50; SE, 0.66; 95% CI, −2.79 to −4.82), and stearoylcarnitine with greater odds of rapid weight gain (odds ratio, 1.66; 95% CI, 1.23 to 2.25). GD was associated with greater length for age z scores (β = 0.48; SE, 0.22; 95% CI, 0.04 to 0.91). Conclusions and Relevance In this observational cohort study, GD was associated with altered concentrations of several human milk metabolites. The associations between these metabolites and infant growth suggest that milk compositional differences in mothers with GD may beneficially moderate the growth and body composition of their infants.
Contrastive machine learning reveals species -shared and -specific brain functional architecture
Authors: Li Yang, Guannan Cao, Songyao Zhang, Weihan Zhang, Yusong Sun, Jingchao Zhou, Tianyang Zhong, Yixuan Yuan, Tao Liu, Tianming Liu, Lei Guo, Yongchun Yu, Xi Jiang, Gang Li, Junwei Han, Tuo Zhang
Journal: Medical Image Analysis (2024)
Polygenic Risk Scores for Prostate Cancer
Authors: Konrad H. Stopsack
Journal: JAMA Oncology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Bilateral Mastectomy vs Lumpectomy and Breast Cancer Mortality Risk—Reply
Authors: Steven A. Narod, Vasily Giannakeas
Journal: JAMA Oncology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Anabolic Steroid Initiation Among Boys and Young Men After Use of Muscle-Building Supplements
Authors: Abigail Bulens, Jerel P. Calzo, Trine Tetlie Eik-Nes, Ariel Beccia, Amanda Raffoul, Vishnudas Sarda, S. Bryn Austin
Journal: JAMA Network Open (2024)

This cohort study examines the prospective association between muscle-building supplement use among boys and young men and subsequent initiation of anabolic-androgenic steroids.
Seven days in medicine: 4-10 December 2024
Journal: BMJ (2024)

ObesityTV junk food ads will be banned before 9 pm TV advertisements for junk food products will be allowed only after the 9 pm watershed from October 2025 as part of plans to curb childhood obesity, the UK government announced. 1Paid online junk food advertisements will also be banned to help reduce children's exposure to foods high in fat, sugar, or salt.The health secretary, Wes Streeting, said, "Obesity robs our kids of the best possible start in life, sets them up for a lifetime of health problems, and costs the NHS billions." Life expectancy Data show 10 year geographical divideLife expectancy in much of Great Britain is still below pre-pandemic levels, showed data from the Office for National Statistics. 2 The gap between local areas' highest and lowest life expectancies is now 10.3 years in males and 7.6 years in females, both wider than in 2001-03.The 10 areas with the highest male life expectancies at birth were all located in the south of England, while the 10 lowest were in Scotland, the north of England, and Wales.
Estimation of prevalence of autoimmune diseases in the United States using electronic health record data
Authors: Aaron H. Abend, Ingrid He, Neil Bahroos, Stratos Christianakis, Ashley B. Crew, Leanna M. Wise, Gloria P. Lipori, Xing He, Shawn N. Murphy, Christopher D. Herrick, Jagannadha Avasarala, Mark G. Weiner, Jacob S. Zelko, Erica Matute-Arcos, Mark Abajian, Philip R.O. Payne, Albert M. Lai, Heath A. Davis, Asher A. Hoberg, Chris E. Ortman, Amit D. Gode, Bradley W. Taylor, Kristen I. Osinski, Damian N. Di Florio, Noel R. Rose, Frederick W. Miller, George C. Tsokos, DeLisa Fairweather
Journal: Journal of Clinical Investigation (2024)

BACKGROUND. Previous epidemiologic studies of autoimmune diseases in the United States (US) have included a limited number of diseases or used meta-analyses that rely on different data collection methods and analyses for each disease.
Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial
Authors: Icro Meattini, Maria Carmen De Santis, Luca Visani, Marta Scorsetti, Alessandra Fozza, Bruno Meduri, Fiorenza De Rose, Elisabetta Bonzano, Agnese Prisco, Valeria Masiello, Eliana La Rocca, Ruggero Spoto, Carlotta Becherini, Gladys Blandino, Luca Moscetti, Riccardo Ray Colciago, Riccardo A Audisio, Etienne Brain, Saverio Caini, Marije Hamaker, Orit Kaidar-Person, Matteo Lambertini, Livia Marrazzo, Calogero Saieva, Tanja Spanic, Vratislav Strnad, Sally Wheelwright, Philip M P Poortmans, Lorenzo Livi, Icro Meattini, Maria Carmen De Santis, Luca Visani, Marta Scorsetti, Alessandra Fozza, Bruno Meduri, Fiorenza De Rose, Elisabetta Bonzano, Agnese Prisco, Valeria Masiello, Eliana La Rocca, Ruggero Spoto, Carlotta Becherini, Gladys Blandino, Luca Moscetti, Riccardo Ray Colciago, Riccardo A Audisio, Etienne Brain, Saverio Caini, Marije Hamaker, Orit Kaidar Person, Matteo Lambertini, Livia Marrazzo, Tanja Spanic, Vratislav Strnad, Sally Wheelwright, Philip M P Poortmans, Lorenzo Livi, Francesca Martella, Lorenzo Vinante, Sara Ramella, Marco Gatti, Sara Pedretti, Patrizia Vici, Nadia G Di Muzio, Alice Pastorino, Maria Cristina Leonardi, Ivica Ratosa, Jure Verbancic
Journal: The Lancet Oncology (2024)
Relationship between donor source, pre-transplant measurable residual disease, and outcome after allografting for adults with acute myeloid leukemia
Authors: Corentin Orvain, Filippo Milano, Eduardo Rodríguez-Arbolí, Megan Othus, Effie W. Petersdorf, Brenda M. Sandmaier, Frederick R. Appelbaum, Roland B. Walter
Journal: Leukemia (2024)
Evolutionary novelty of Apolipoprotein D facilitates metabolic plasticity in lepidopteran wings
Authors: Shunze Jia, Rongqiao Li, Yinghui Li, Yuxin Huang, Minmin Liu, Yanyan Zhou, Yanting Liang, Zhihua Hao, Yusong Xu, Huabing Wang
Journal: Molecular Biology and Evolution (2024)

Abstract Understanding metabolic plasticity of animal evolution is a fundamental challenge in evolutionary biology. Owing to the diversification of insect wing morphology and dynamic energy requirements, the molecular adaptation mechanisms underlying the metabolic pathways in wing evolution remain largely unknown. This study reveals the pivotal role of the duplicated Apolipoprotein D (ApoD) gene in lipid and energy homeostasis in the lepidopteran wing. ApoD underwent significant expansion in insects, with gene duplication and consistent retention observed in Lepidoptera. Notably, duplicated ApoD2 was highly expressed in lepidopteran wings and encoded a unique C-terminal tail, conferring distinct ligand-binding properties. Using Bombyx mori as a model organism, we integrated evolutionary analysis, multiomics, and in vivo functional experiments to elucidate the way duplicated ApoD2 mediates lipid trafficking and homeostasis via the AMP-activated protein kinase pathway in wings. Moreover, we revealed the specific expression and functional divergence of duplicated ApoD as a key mechanism regulating lipid homeostasis in the lepidopteran wing. These findings highlight an evolutionary scenario in which neofunctionalization conferred a novel role of ApoD in shaping adaptive lipid metabolic regulatory networks during wing phenotypic evolution. Overall, we provide in vivo evidence for the functional differentiation of duplicate genes in shaping adaptive metabolic regulatory networks during phenotypic evolution.
A graph-based goat pangenome reveals structural variations involved in domestication and adaptation
Authors: Peipei Bian, Jiaxin Li, Shishuo Zhou, Xingquan Wang, Mian Gong, Xi Guo, Yudong Cai, Qimeng Yang, Jiaqi Fu, Rongrong Li, Shuhong Huang, Funong Luo, Ali Mujtaba Shah, Johannes A Lenstra, Joram M Mwacharo, Ran Li, Gang Ren, Xiaolong Wang, Cong Li, Wenxin Zheng, Yu Jiang, Xihong Wang
Journal: Molecular Biology and Evolution (2024)

Abstract Pangenomes can facilitate a deeper understanding of genome complexity. Using de novo phased long-read assemblies of eight representative goat breeds, we constructed a graph-based pangenome of goats (Capra hircus) and discovered 113 Mb autosomal novel sequences. Combining this multi-assembly pangenome with low-coverage PacBio HiFi sequences, we constructed a long-read structural variations (SVs) database containing 59,325 SV deletions, 84,910 SV insertions and 24,954 other complex SV alleles. This resource allowed reliable graph-based genotyping from short reads of 79 wild and 1,148 worldwide domestic goats. Selection signal analysis of SV captured a novel immune-related domestication locus containing the galectin-9 gene and extra copies of the ruminant-specific galectin-9-like genes (LGALS9L), which have high tissue specificity. A segmental duplication in domestic goats generates three additional LGALS9L copies. Ancient goat genome sequences show a gradual increase in frequency of this duplication from the Neolithic to the present. Two other newly detected SVs also have higher selection signals than adjacent SNPs, a truncated-LINE1 deletion in EDAR2 associated with cashmere production and a VNTR-related insertion in PAPSS2 linked to high-altitude adaptation. In summary, the multi-assembly goat pangenome and long-read SV database facilitates detecting complex variations that are important in evolution and selection.
Impact and cost-effectiveness of scaling up HCV testing and treatment strategies for achieving HCV elimination among people who inject drugs in England: a mathematical modelling study
Authors: Zoe Ward, Ruth Simmons, Hannah Fraser, Adam Trickey, Jo Kesten, Andy Gibson, Leila Reid, Sean Cox, Fiona Gordon, Stuart Mc Pherson, Stephen Ryder, Javier Vilar, Alec Miners, Jack Williams, Beatrice Emmanouil, Monica Desai, Laura Coughlan, Ross Harris, Graham R Foster, Matthew Hickman, Sema Mandal, Peter Vickerman
Journal: The Lancet Regional Health - Europe (2024)