tbuckley/cabot-search huggingface dataset:
Hemithyroidectomy Versus Total Thyroidectomy for Sporadic Medullary Thyroid Cancer: A Chinese Nationwide Large-Scale Cohort Study
Authors: Xiao Shi, Cenkai Shen, Chuqiao Liu, Likun Zhang, Yuxin Du, Hao Zhang, Hongwei Liu, Jianbiao Wang, Chuang Chen, Yijun Wu, Chunyan Zhang, Zimeng Li, Haitao Tang, Min Yin, Xiaoqi Mao, Shuyi Liu, Yaoting Sun, Yan Zhou, Wenjun Wei, Naisi Huang, Zhihong Wang, Zhiqiang Gui, Hanqing Liu, Jiaxi Wang, Jian Li, Cuiwei Li, Shiyu Xiang, Liang Guo, Yan Zhang, Yi He, Tiannan Guo, Qinghai Ji, Zhiyan Liu, Yu Wang
Journal: Journal of the National Comprehensive Cancer Network (2025)

Medullary thyroid cancer (MTC) is a rare thyroid malignancy, with 70% to 80% of cases being sporadic (sMTC). Current guidelines recommend total thyroidectomy (TT) for all preoperatively suspicious sMTC, though there has been increasing support for reducing the surgical extent in recent years. However, relevant data are limited. This study aimed to comprehensively evaluate the safety of hemithyroidectomy (HT) in sMTC. This study included 797 patients with MTC who received curative-intent initial surgery at 19 participating referral centers. Genetic testing was performed to identify disease heredity. We evaluated the safety of HT in sMTC across 5 aspects: (1) prevalence of occult bilateral foci, (2) prevalence of contralateral lobe recurrence, (3) biochemical response, (4) structural recurrence-free survival (SRFS), and (5) overall survival (OS). Of the 797 patients, 648 were genetically confirmed as having sMTC. HT and TT were performed as the index surgery in 232 (35.8%) and 416 (64.2%) patients, respectively. In the TT group, bilateral foci were found in 34 (8.2%) patients, of whom only 10 (2.4%) had sonographically occult foci, and of these, only 3 (0.72%) had a maximal tumor size ≤2 cm. In the HT group, only 1.7% (4/232) had recurrence in the preserved lobe, with only 1 (0.43%) having a maximal tumor size ≤2 cm. After propensity score matching, 230 pairs of patients were included in further analysis. No significant differences were found in OS (log-rank: P=.484; Cox regression: P=.380), SRFS (log-rank: P=.914; Cox regression: P=.309), or biochemical response (chi-square: P=.744; logistic regression: P=.818) between the 2 groups. Subgroup analyses showed that HT conferred comparable structural and biochemical outcomes with TT in small (≤2 cm) sMTCs, even for patients with high-risk factors such as high preoperative calcitonin, multifocal disease, lymph node metastases, RETM918T mutation, and desmoplasia. For small unilateral sMTCs, HT may be considered an alternative treatment that does not compromise prognosis while avoiding additional complications associated with TT.
The JAK2 46/1 haplotype influences PD-L1 expression.
Authors: Gonzalo Carreño-Tarragona, Maria Tiana, Raquel Rouco, Alejandra Leivas, Jesús Victorino, Roberto Garcia-Vicente, Andrew J Chase, Andrea Maidana, William J Tapper, Rosa Ayala, Nicholas C.P. Cross, Joaquín Martínez-López, Miguel Manzanares
Journal: Blood (2025)
Targeting cell surface VISTA expression on allospecific naïve T cells promotes tolerance
Authors: Brent H Koehn, Elizabeth C Nowak, Sladjana Skopalja-Gardner, Asim Saha, Michael C. Zaiken, Jeremy R Allred, Yiyung Peng, Wilson Lloyd Davis, Isabelle Le Mercier, Nicholas Schwertner, Michael J Molloy, Jay Rothstein, Catherine Carriere, Megan J Riddle, Cindy Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Kyle D Smith, Keli L. Hippen, Tae Kon Kim, Randolph J Noelle, Bruce R Blazar
Journal: Blood (2025)
Proteomics guided biomarker discovery, validation, and pathway perturbation in infection-related acute decompensation of cirrhosis
Authors: Pratibha Garg, Nipun Verma, Arun Valsan, Vivek Sarohi, Trayambak Basak, Tarana Gupta, Parminder Kaur, Samonee Ralmilay, Shreya Singh, Arka De, Madhumita Premkumar, Sunil Taneja, Ajay Duseja, Virendra Singh, Jasmohan S Bajaj
Journal: Clinical Gastroenterology and Hepatology (2025)
Biocompatible Metal‐Organic Framework‐Based Fabric Composite as an Efficient Personal Protective Equipment for Particulate Matter‐Induced Pulmonary Injury (Adv. Healthcare Mater. 4/2025)
Authors: Zhen Ding, Xingfu Bao, Tianyan Chen, Jinming Zhang, Chengjing Xu, Nan Tang, Min Hu, Zhen Liu
Journal: Advanced Healthcare Materials (2025)

Advanced Healthcare MaterialsVolume 14, Issue 4 2570026 Back CoverFree Access Biocompatible Metal-Organic Framework-Based Fabric Composite as an Efficient Personal Protective Equipment for Particulate Matter-Induced Pulmonary Injury (Adv. Healthcare Mater. 4/2025) Zhen Ding, Zhen DingSearch for more papers by this authorXingfu Bao, Xingfu BaoSearch for more papers by this authorTianyan Chen, Tianyan ChenSearch for more papers by this authorJinming Zhang, Jinming ZhangSearch for more papers by this authorChengjing Xu, Chengjing XuSearch for more papers by this authorNan Tang, Nan TangSearch for more papers by this authorMin Hu, Min HuSearch for more papers by this authorZhen Liu, Zhen LiuSearch for more papers by this author Zhen Ding, Zhen DingSearch for more papers by this authorXingfu Bao, Xingfu BaoSearch for more papers by this authorTianyan Chen, Tianyan ChenSearch for more papers by this authorJinming Zhang, Jinming ZhangSearch for more papers by this authorChengjing Xu, Chengjing XuSearch for more papers by this authorNan Tang, Nan TangSearch for more papers by this authorMin Hu, Min HuSearch for more papers by this authorZhen Liu, Zhen LiuSearch for more papers by this author First published: 07 February 2025 https://doi.org/10.1002/adhm.202570026AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechat Graphical Abstract Personal Protective Equipment Copper-based metal-organic frameworks with great adsorbing/antioxidant/antibacterial performance and high biosafety are developed using a facile oxygen-free hydrothermal approach. After the incorporation with cellulose acetate membrane, these fabric composites can reduce the unwanted pulmonary toxicity and avoid the behavioral changes in mice after the exposure of particulate matter. More details can be found in article 2403061 by Xingfu Bao, Nan Tang, Min Hu, Zhen Liu, and co-workers. Volume14, Issue4February 7, 20252570026 RelatedInformation
Human Tendon‐on‐a‐Chip for Modeling the Myofibroblast Microenvironment in Peritendinous Fibrosis (Adv. Healthcare Mater. 4/2025)
Authors: Raquel E. Ajalik, Isabelle Linares, Rahul G. Alenchery, Victor Z. Zhang, Terry W. Wright, Benjamin L. Miller, James L. McGrath, Hani A. Awad
Journal: Advanced Healthcare Materials (2025)

Advanced Healthcare MaterialsVolume 14, Issue 4 2570024 FrontispieceFree Access Human Tendon-on-a-Chip for Modeling the Myofibroblast Microenvironment in Peritendinous Fibrosis (Adv. Healthcare Mater. 4/2025) Raquel E. Ajalik, Raquel E. AjalikSearch for more papers by this authorIsabelle Linares, Isabelle LinaresSearch for more papers by this authorRahul G. Alenchery, Rahul G. AlencherySearch for more papers by this authorVictor Z. Zhang, Victor Z. ZhangSearch for more papers by this authorTerry W. Wright, Terry W. WrightSearch for more papers by this authorBenjamin L. Miller, Benjamin L. MillerSearch for more papers by this authorJames L. McGrath, James L. McGrathSearch for more papers by this authorHani A. Awad, Hani A. AwadSearch for more papers by this author Raquel E. Ajalik, Raquel E. AjalikSearch for more papers by this authorIsabelle Linares, Isabelle LinaresSearch for more papers by this authorRahul G. Alenchery, Rahul G. AlencherySearch for more papers by this authorVictor Z. Zhang, Victor Z. ZhangSearch for more papers by this authorTerry W. Wright, Terry W. WrightSearch for more papers by this authorBenjamin L. Miller, Benjamin L. MillerSearch for more papers by this authorJames L. McGrath, James L. McGrathSearch for more papers by this authorHani A. Awad, Hani A. AwadSearch for more papers by this author First published: 07 February 2025 https://doi.org/10.1002/adhm.202570024AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechat Graphical Abstract Tendon-on-a-Chip A novel human Tendon-on-a-Chip model replicates aspects of the myofibroblast microenvironment in peritendinous adhesions. This chip sheds light on cellular and molecular crosstalk between immune cells, endothelial cells, and myofibroblasts, offering a powerful tool for drug testing and de-risking drug development for fibrotic diseases. More details can be found in article 2403116 by Hani A. Awad and co-workers. Volume14, Issue4February 7, 20252570024 RelatedInformation
Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications (Adv. Healthcare Mater. 4/2025)
Authors: Priyanka Singh, Santosh Pandit, Sri Renukadevi Balusamy, Mukil Madhusudanan, Hina Singh, H. Mohamed Amsath Haseef, Ivan Mijakovic
Journal: Advanced Healthcare Materials (2025)

Advanced Healthcare MaterialsVolume 14, Issue 4 2570023 FrontispieceFree Access Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications (Adv. Healthcare Mater. 4/2025) Priyanka Singh, Priyanka SinghSearch for more papers by this authorSantosh Pandit, Santosh PanditSearch for more papers by this authorSri Renukadevi Balusamy, Sri Renukadevi BalusamySearch for more papers by this authorMukil Madhusudanan, Mukil MadhusudananSearch for more papers by this authorHina Singh, Hina SinghSearch for more papers by this authorH. Mohamed Amsath Haseef, H. Mohamed Amsath HaseefSearch for more papers by this authorIvan Mijakovic, Ivan MijakovicSearch for more papers by this author Priyanka Singh, Priyanka SinghSearch for more papers by this authorSantosh Pandit, Santosh PanditSearch for more papers by this authorSri Renukadevi Balusamy, Sri Renukadevi BalusamySearch for more papers by this authorMukil Madhusudanan, Mukil MadhusudananSearch for more papers by this authorHina Singh, Hina SinghSearch for more papers by this authorH. Mohamed Amsath Haseef, H. Mohamed Amsath HaseefSearch for more papers by this authorIvan Mijakovic, Ivan MijakovicSearch for more papers by this author First published: 07 February 2025 https://doi.org/10.1002/adhm.202570023AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechat Graphical Abstract Green Nanoparticles This frontispiece illustrates green nanoparticles delivery in cancer cells, with nanoparticles represented as green particles released from a capsule toward a tumor. The futuristic background and neon ring emphasize the innovative approach of nanomedicine, showcasing nanoparticles' potential to precisely target cancer cells while sparing healthy tissue. More details can be found in article 2403059 by Priyanka Singh, Ivan Mijakovic, and co-workers. Volume14, Issue4February 7, 20252570023 RelatedInformation
Engineering Macrophage‐Derived Exosome to Deliver Pirfenidone: A Novel Approach to Combat Silicotic Pulmonary Fibrosis (Adv. Healthcare Mater. 4/2025)
Authors: Zhen Chen, Xiang Yun, Jiaqi Tian, Fei Li, Zitong Zhang, Jiahua Meng, Ning Li, Hongying Bian, Shuyin Duan, Lin Zhang
Journal: Advanced Healthcare Materials (2025)

Advanced Healthcare MaterialsVolume 14, Issue 4 2570020 Cover PictureFree Access Engineering Macrophage-Derived Exosome to Deliver Pirfenidone: A Novel Approach to Combat Silicotic Pulmonary Fibrosis (Adv. Healthcare Mater. 4/2025) Zhen Chen, Zhen ChenSearch for more papers by this authorXiang Yun, Xiang YunSearch for more papers by this authorJiaqi Tian, Jiaqi TianSearch for more papers by this authorFei Li, Fei LiSearch for more papers by this authorZitong Zhang, Zitong ZhangSearch for more papers by this authorJiahua Meng, Jiahua MengSearch for more papers by this authorNing Li, Ning LiSearch for more papers by this authorHongying Bian, Hongying BianSearch for more papers by this authorShuyin Duan, Shuyin DuanSearch for more papers by this authorLin Zhang, Lin ZhangSearch for more papers by this author Zhen Chen, Zhen ChenSearch for more papers by this authorXiang Yun, Xiang YunSearch for more papers by this authorJiaqi Tian, Jiaqi TianSearch for more papers by this authorFei Li, Fei LiSearch for more papers by this authorZitong Zhang, Zitong ZhangSearch for more papers by this authorJiahua Meng, Jiahua MengSearch for more papers by this authorNing Li, Ning LiSearch for more papers by this authorHongying Bian, Hongying BianSearch for more papers by this authorShuyin Duan, Shuyin DuanSearch for more papers by this authorLin Zhang, Lin ZhangSearch for more papers by this author First published: 07 February 2025 https://doi.org/10.1002/adhm.202570020AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechat Graphical Abstract Exosome-Based Nano Drug Delivery System Macrophage-derived exosomes offer a novel approach to deliver pirfenidone (PFD) for treating silicotic pulmonary fibrosis. In article 2403227, Shuyin Duan, Lin Zhang, and co-workers demonstrate that PFD-loaded exosomes effectively inhibit fibroblast activation and reduce lung fibrosis in a mouse model of silicosis, while potentially mitigating systemic side effects. The cover illustrates lung-originating macrophages secreting exosomes engineered to encapsulate PFD for targeted pulmonary delivery. Volume14, Issue4February 7, 20252570020 RelatedInformation
Pseudo‐3D Topological Alignments Regulate Mechanotransduction and Maturation of Smooth Muscle Cells (Adv. Healthcare Mater. 4/2025)
Authors: Yeji Lee, Jihyeon Song, Ulziituya Batjargal, Min‐Seok Kim, Geonho Lee, Geonwoo Kim, Taehoon Lee, RaeHui Kang, Younggyun Kim, Han‐Jun Kim, Junmin Lee
Journal: Advanced Healthcare Materials (2025)

Advanced Healthcare MaterialsVolume 14, Issue 4 2570025 Inside Back CoverFree Access Pseudo-3D Topological Alignments Regulate Mechanotransduction and Maturation of Smooth Muscle Cells (Adv. Healthcare Mater. 4/2025) Yeji Lee, Yeji LeeSearch for more papers by this authorJihyeon Song, Jihyeon SongSearch for more papers by this authorUlziituya Batjargal, Ulziituya BatjargalSearch for more papers by this authorMin-Seok Kim, Min-Seok KimSearch for more papers by this authorGeonho Lee, Geonho LeeSearch for more papers by this authorGeonwoo Kim, Geonwoo KimSearch for more papers by this authorTaehoon Lee, Taehoon LeeSearch for more papers by this authorRaeHui Kang, RaeHui KangSearch for more papers by this authorYounggyun Kim, Younggyun KimSearch for more papers by this authorHan-Jun Kim, Han-Jun KimSearch for more papers by this authorJunmin Lee, Junmin LeeSearch for more papers by this author Yeji Lee, Yeji LeeSearch for more papers by this authorJihyeon Song, Jihyeon SongSearch for more papers by this authorUlziituya Batjargal, Ulziituya BatjargalSearch for more papers by this authorMin-Seok Kim, Min-Seok KimSearch for more papers by this authorGeonho Lee, Geonho LeeSearch for more papers by this authorGeonwoo Kim, Geonwoo KimSearch for more papers by this authorTaehoon Lee, Taehoon LeeSearch for more papers by this authorRaeHui Kang, RaeHui KangSearch for more papers by this authorYounggyun Kim, Younggyun KimSearch for more papers by this authorHan-Jun Kim, Han-Jun KimSearch for more papers by this authorJunmin Lee, Junmin LeeSearch for more papers by this author First published: 07 February 2025 https://doi.org/10.1002/adhm.202570025AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechat Graphical Abstract Topological Cues Affect Smooth Muscle Cell This cover uses the "Three Little Pigs" analogy to explain how topological cues affect smooth muscle cell mechanotransduction and maturation. On flat surfaces, cells build simple "straw houses," representing less mature growth, while on complex terrains, they construct "brick houses," signifying enhanced maturity. The pseudo-3D muscle mimic model highlights how environmental structure influences mechanotransduction and muscle cell phenotype. More details can be found in article 2402492 by Han-Jun Kim, Junmin Lee, and co-workers. Volume14, Issue4February 7, 20252570025 RelatedInformation
Subcellular enrichment patterns of new genes in <i>Drosophila</i> evolution
Authors: Chuan Dong, Shengqian Xia, Li Zhang, Deanna Arsala, Chengchi Fang, Shengjun Tan, Andrew G Clark, Manyuan Long
Journal: Molecular Biology and Evolution (2025)

Abstract The evolutionary patterns of proteins within subcellular compartments underlie the innovation and diversification foundation of the living eukaryotic organism. The location of proteins in subcellular compartments promotes the formation of network interaction modules, which in turn reshape the architecture of higher-level protein-protein interaction networks. Here, we conducted the most up-to-date gene-age dating of Drosophila melanogaster by employing recent available long-read sequencing genomes as references. We found that an elevated gene fixation in the most recent common ancestor (MRCA) of Drosophila genus predated the divergence between two Drosophila subgenera, and a significant tendency of these genes in D. melanogaster encode proteins that localize to the extracellular matrix, accompanying the adaptive radiation of Drosophila species. Proteins encoded by genes located in the extracellular space exhibit higher sequence divergence, suggesting a rapid evolutionary process. We also observed that proteins encoded by genes originating from the same evolutionary branches tend to co-localize in the same subcellular compartments, and proteins in the same subcellular compartment tend to interact with each other. The proteins encoded by genes that have persisted through deeper branches exhibit broader localization across multiple subcellular compartments, enhancing the likelihood of their integration into various protein or gene regulatory networks, thereby increasing functional diversity. These evolutionary patterns not only contribute to understanding the evolution of subcellular localization in proteins encoded by genes originating from different branches, but also provide insights into the evolution of protein-protein networks driven by the emergence of new genes.
Impact of margin thermal ablation after cold-forceps avulsion with snare-tip soft coagulation for non-lifting large non-pedunculated colorectal polyps
Authors: Francesco Vito Mandarino, Timothy O'Sullivan, Julia Louisa Gauci, Clarence Kerrison, Anthony Whitfield, Brian Lam, Varan Perananthan, Sunil Gupta, Oliver Cronin, Renato Medas, David J Tate, Eric Y Lee, Nicholas G Burgess, Michael J. Bourke
Journal: Endoscopy (2025)

Non-lifting large non-pedunculated colorectal polyps (NL-LNPCPs) account for 15% of LNPCP and are effectively managed by Endoscopic Mucosal Resection with adjunctive Cold-forceps Avulsion with adjuvant Snare-Tip soft coagulation (CAST). However, recurrence rates > 10% at surveillance colonoscopy is a significant limitation. We aimed to compare the outcomes of CAST with MTA versus CAST alone for NL-LNPCPs. Prospective observational data on consecutive patients with NL-LNPCPs treated by EMR and CAST at a single tertiary center was retrospectively evaluated. Two cohorts were established: the pre-MTA period (January 2012-June 2017) and the MTA period (July 2017-October 2023). The primary outcome was the residual/recurrent adenoma (RRA) rate at first surveillance colonoscopy (SC1). Secondary outcomes included RRA at SC2 and adverse events. Over 142 months, 300 patients underwent EMR and CAST for LNPCP: 103 lesions pre-MTA and 197 with MTA. At SC1 and SC2, recurrence was lower in the MTA cohort compared to the pre-MTA cohort (5.0% vs. 18.8%, p<0.001 and 0.8% vs. 10.0%, p<0.001, respectively). Adverse events were similar between the two cohorts [deep mural injury types III-V (pre-MTA 2.9% vs MTA 5.6%, p=0.29), delayed bleeding (pre-MTA 8.7% vs MTA 7.1%, p=0.49)]. On multivariate analysis, MTA was the only variable independently associated with a reduced likelihood of recurrence (OR 0.20, 95% CI 0.07-0.54; P = 0.001). For NL-LNPCPs, MTA in combination with CAST is safe and effective and reduces recurrence at SC1 in comparison to CAST alone.
Loss of Bach2 in T cells causes prolonged allergic inflammation through the accumulation of effector T cells and disruption of the epidermal barrier
Authors: Miyuki Omori-Miyake, Ryosuke Kawakami, Makoto Kuwahara, Masataka Okabe, Jun Muto, Takeshi Imamura, Masakatsu Yamashita
Journal: Journal of Allergy and Clinical Immunology (2025)
Portal versus peripheral circulating tumor cells as prognostic biomarkers in patients with stage I-III pancreatic ductal adenocarcinoma
Authors: Thaninee Prasoppokakorn, Roongruedee Chaiteerakij, Areeya Buntho, Praewphan Ingrungruanglert, Nipan Israsena, Wiriyaporn Rittitid, Phonthep Angsuwatcharakon, Parit Mekaroonkamol, Pradermchai Kongkam, Rungsun Rerknimitr
Journal: Endoscopy (2025)

Background: Portal venous circulating tumor cells (CTCs) detection may better reflect vascular metastasis and predict micro-metastasis risk in PDAC than peripheral blood. We hypothesize that portal CTCs could better represent micro-metastasis and predict survival in PDAC patients. Methods: A single-center, prospective cohort study of patients with stage I-III PDAC was conducted. Portal venous blood was obtained via EUS-guided sampling, and peripheral blood was collected on the same day. CTCs were detected using EpCAM and mucin1 antibodies and reported as cells/8mL of blood. Results: Among 35 patients, portal and peripheral CTC detection rates were 94.3% and 82.9%, respectively. Advanced PDAC with loco-regional metastasis had higher portal CTCs than less aggressive disease (p&lt;0.05), while peripheral CTCs showed no significant differences. During the 50-month follow-up, patients with portal CTCs≥8 had poorer survival (6.1 vs. 19.0 months, p=0.001) and patients with peripheral CTCs≥3 also had poorer survival (4.6 vs. 14.2 months, p=0.002). In multivariable analysis, both portal CTCs≥8 and peripheral CTCs≥3 showed significant adjusted associations with survival (aHRs 3.39 and 2.71; p=0.009 and 0.020). Conclusion: Higher CTC counts in both portal and peripheral systems were significantly associated with poorer survival in stage I-III PDAC; however, only portal CTCs reflected tumor aggression and loco-regional metastasis.