THE PROBLEM OF THE DEVELOPMENT OF HYPERSENSITIVENESS IN MAN
Authors: Frank A. Simon
Journal: Annals of Internal Medicine (1938)

Article1 August 1938THE PROBLEM OF THE DEVELOPMENT OF HYPERSENSITIVENESS IN MANFRANK A. SIMON, M.D.FRANK A. SIMON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-2-178 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFrom the standpoint of their development the several types of hypersensitiveness may be divided into two groups. Those in the first group are characterized by the fact that, in a given animal species, all individuals that are adequately exposed to a suitable allergen become sensitized. These types of hypersensitiveness, therefore, may be reproduced at will. In this group there are (A) the hypersensitiveness of infections, such as tuberculosis, pneumococcus infections, trichophyton infection, etc. (B) The hypersensitiveness which follows the parenteral injection of foreign substances, such as foreign blood serums (anaphylactic hypersensitiveness). (C) Contact eczema of the type which can be...References1. STRAUS HW: Artificial sensitization of infants to poison ivy, Jr. Allergy, 1931, ii, 137. CrossrefGoogle Scholar2. STRAUS HW: Studies in experimental hypersensitiveness in the rhesus monkey, 1. Active sensitization with poison ivy, Jr. Immunol., 1937, xxxii, 241. Google Scholar3. SIMONSIMONRACKEMANNDIENES FAMGFML: The sensitization of guinea pigs to poison ivy, Jr. Immunol., 1934, xxvii, 113. Google Scholar4. VON PIRQUETSCHICK CB: Zur Theorie der Incubationzeit; Vorlaufige Mitteilung, Wien. klin. Wchnschr., 1903, xvi, 758. Google Scholar5. DIENESSIMON LFA: The flaring up of injection sites in allergic guinea pigs, Jr. Immunol., 1935, xxviii, 321. Google Scholar6. DIENESSCHOENHEIT LEW: The reproduction of tuberculin hypersensitiveness in guinea pigs with various protein substances, Am. Rev. Tuberc., 1929, xx, 92. Google Scholar7. COCAWALZERTHOMMEN AFMAA: Asthma and hay fever in theory and practice, Chas. C. Thomas, pgs. 38 to 57. Google Scholar8. RACKEMANN FM: The nature of allergy, Trans. Am. Clin. and Climat. Assoc., 1930, xlvi, 72. Google Scholar9. RACKEMANNSIMONSIMONSCULLY FMFAMGMA: Further observations on the nature of allergy, Jr. Allergy, 1933, iv, 498. CrossrefGoogle Scholar10. SIMONRACKEMANN FAFM: The development of hypersensitiveness in man, Jr. Allergy, 1934, v, 439. CrossrefGoogle Scholar11. WALZER M: A direct method of demonstrating the absorption of incompletely digested proteins in normal human beings, Jr. Immunol., 1926, xi, 249. Google Scholar12. COHENECKERRUDOLPH MBEEJA: Disappearance time of circulating ragweed pollen material after absorption from nose and throat, Jr. Allergy, 1930, i, 529. CrossrefGoogle Scholar13. SULZBERGERVAUGHAN MBWT: Experiments in silk sensitivity and the inhalation of allergen in atopic dermatitis, Jr. Allergy, 1934, v, 554. CrossrefGoogle Scholar14. WELLS HG: The present status of the problems of anaphylaxis, Phys. Rev., 1921, i, 44. CrossrefGoogle Scholar15. TUFT L: Insulin hypersensitiveness, immunologic considerations and case reports, Am. Jr. Med. Sci., 1928, clxxvi, 707. CrossrefGoogle Scholar16. SIMONRYDER FACF: Hypersensitiveness to pituitary extracts, Jr. Am. Med. Assoc., 1936, cvi, 512. CrossrefGoogle Scholar17. SPAINNEWELLMEEKER WCJMMG: The percentage of persons susceptible to poison ivy and poison oak, Jr. Allergy, 1934, v, 571. CrossrefGoogle Scholar18. BRUNNER M: Active sensitization in human beings, Jr. Allergy, 1932, iii, 521. Google Scholar19. FIELDSULZBERGER HMB: Experiments in poison ivy sensitivity, Jr. Allergy, 1936, vii, 139. CrossrefGoogle Scholar20. CRIEP LH: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisville, Kentucky*Received for publication August 7, 1937.From the Department of Medicine, University of Louisville, School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAllergy in the Domestic Animals 1 August 1938Volume 12, Issue 2Page: 178-188KeywordsAllergensBloodEczemaPneumococcusTuberculosis ePublished: 1 December 2008 Issue Published: 1 August 1938 PDF downloadLoading ...