tbuckley/cabot-search huggingface dataset:
Tenapanor Reduces Serum Phosphate with Similar Efficacy and Tolerability Profiles When Added to Various Phosphate Binders
Authors: Stuart M. Sprague, David P. Tietjen, Jesslyn Roesch, Yang Yang, Suling Zhao, Susan A. Edelstein, David P. Rosenbaum, David M. Spiegel
Journal: Journal of the American Society of Nephrology (2024)
Increased Mortality Risk Is Associated with Abnormal Iron Status in Japanese Patients on Hemodialysis: A Nationwide Cohort Study
Authors: Hiroki Nishiwaki, Takahiro Imaizumi, Takeshi Hasegawa, Takaaki Kosugi, Yukio Maruyama, Kazuhiko Tsuruya, Yasuhiko Ito, Hirokazu Honda, Takahiro Kuragano
Journal: Journal of the American Society of Nephrology (2024)
Fibrillary Glomerulonephritis Treated with Rituximab and Cyclophosphamide Combination Therapy: A Retrospective Cohort Study
Authors: Gabriel Sauvage, Reza Zonozi, Orhan Efe, Anushya Jeyabalan, Katherine M. Cosgrove, Karen A. Laliberte, John Niles, Ayman Al Jurdi
Journal: Journal of the American Society of Nephrology (2024)
Health Trajectories of Adults with ESKD and Obesity Who Are Trying to Lose Weight
Authors: Dahlia Stott, Bengucan Gunen, Stephen Chien, Brandy-Joe Milliron, Ann Carroll Klassen, Lucy Robinson, Jason Cobb, Alden Michael Doyle, Meera Nair Harhay
Journal: Journal of the American Society of Nephrology (2024)
Alfacalcidol vs. Calcitriol in the Management of Secondary Hyperparathyroidism in CKD
Authors: Muriel Ghosn, Wasim El Nekidy, Jihad Mallat, Fadi A. Hijazi, Rakesh Madhyastha, Emna Abidi, Iyad Ghazal, Amir Riaz Malik
Journal: Journal of the American Society of Nephrology (2024)
Multidisciplinary Inter-rater Reliability of Muscle Ultrasonography in Patients with AKI Requiring Continuous Kidney Replacement Therapy
Authors: J. Pedro Teixeira, Felipe Gonzalez-Seguel, Vinh Tran, Chaitanya A. Pal, Zan Shareef, Hayley Israel, Arimitsu Horikawa-Strakovsky, Yuan Wen, Benjamin R. Griffin, Javier A. Neyra, Kirby Mayer
Journal: Journal of the American Society of Nephrology (2024)
Back to Bedside: Kidney Point-of-Care Ultrasonography (POCUS) by Resident Physicians for Identification of Hydronephrosis in Patients with AKI
Authors: Sundus Sardar, Rohit Sharma, Abdullah Mohammad Arshad, Mohammed Alamin, Bashar Tanous, Jaweria Akram, Fateen Ata, Rawand Jebril, Abdulrahman Al-Mashdali, Zohaib Yousaf, Muhammad Zahid
Journal: Journal of the American Society of Nephrology (2024)
Characterization of GANAB Phenotype in Patients with ADPKD Using Advanced Imaging Biomarkers
Authors: Fadi George Munairdjy Debeh, Vineetha Rangarajan, Ahmad Ghanem, Abdul Hamid Borghol, Stefan N. Paul, Bassel Alkhatib, Nay Nader, Adriana Gregory, Hana Yang, Christian Hanna, Neera K. Dahl, Timothy L. Kline, Peter C. Harris, Fouad T. Chebib
Journal: Journal of the American Society of Nephrology (2024)
Single-Cell Spatial Atlas of Immune and Kidney Cell States in Human Rapidly Progressive Glomerulonephritis
Authors: Zeba Sultana, Robin Khatri, Behnam Yousefi, Nikhat Shaikh, Saskia-L. Jauch-Speer, Varshi Sivayoganathan, Hans-Joachim Paust, Thorsten Wiech, Tobias B. Huber, Ulf Panzer, Stefan Bonn, Christian F. Krebs
Journal: Journal of the American Society of Nephrology (2024)
The TIMING Study: Patients' and Clinicians' Perspectives on Reproductive Health Care and Autosomal Dominant Polycystic Kidney Disease
Authors: Margriet Gosselink, Robin Mooren, Rozemarijn Snoek, Neeltje Crombag, Paul Vos, Mandy G. Keijzer-Veen, Albertien M. van Eerde, Titia Lely
Journal: Journal of the American Society of Nephrology (2024)
Validation of a Combined Biomarker Including FGF-23, Erythropoietin, and Klotho for Development AKI and Clinical Outcomes in Patients in the Intensive Care Unit (ICU)
Authors: Luis Michea, Luis Toro, Veronica Rojas, Daniela Ponce, Carlos Irarrazabal, Danilo Fischer, Carlos Romero, Julia Guerrero
Journal: Journal of the American Society of Nephrology (2024)
Urinary Extracellular Vesicles: Early Indicators of Kidney Allograft Injury after Transplantation
Authors: Maja Vodusek, Maja Stalekar, Katja Goricar, Marija Holcar, Polona Kogovšek, Metka Lenassi, Miha Arnol
Journal: Journal of the American Society of Nephrology (2024)
Characterization of IFT140 Phenotype in Patients with ADPKD Using Advanced Imaging Biomarkers
Authors: Ahmad Ghanem, Fadi George Munairdjy Debeh, Abdul Hamid Borghol, Stefan N. Paul, Bassel Alkhatib, Nay Nader, Adriana Gregory, Hana Yang, Christian Hanna, Neera K. Dahl, Timothy L. Kline, Peter C. Harris, Fouad T. Chebib
Journal: Journal of the American Society of Nephrology (2024)
Fewer Podocytes Associate with Progressive CKD Independent of Glomerular Volume and Nephrosclerosis or Clinical Characteristics
Authors: Aleksandar Denic, Mahesh Kumar, Fnu Aperna, Afsana Ansari Shaik, Aidan F. Mullan, Mariam P. Alexander, Jeffrey B. Hodgin, Andrew D. Rule
Journal: Journal of the American Society of Nephrology (2024)
Nuclear Magnetic Resonance-Based Glomerular Filtration Rate Estimation Is More Closely Associated with Serum Vancomycin Target Trough Achievement vs. Serum Creatinine-Based Equations
Authors: Jason N. Barreto, Amauri Schwäble Santamaría, Marcello Grassi, Andrew Robertson, John C. Lieske, Jeff W. Meeusen, Eric Schiffer, Erin F. Barreto
Journal: Journal of the American Society of Nephrology (2024)
Gut Microbiota Drives Kidney Damage and Cardiac Remodeling in Experimental CKD
Authors: Wibke Anders, Alex Yarritu, Istvan Andras Szijarto, Arne Thiele, Sara A. Hassan, Carina Hoffmann, Ariana Rauch, Franziska Fuckert, Natnael Gebremedhin, Paul Moritz Bonnekoh, Olena Potapenko, Johannes Holle, Hendrik Bartolomaeus, Nicola Wilck
Journal: Journal of the American Society of Nephrology (2024)
Development of a Novel Metabolite Filtration Marker Panel to Improve GFR Estimation
Authors: Jesse C. Seegmiller, Seiei Shiba, Nora F. Fino, Tom Greene, Benjamin Haaland, Josef Coresh, Ogechi M. Adingwupu, Andrew S. Levey, Lesley Ann Inker
Journal: Journal of the American Society of Nephrology (2024)
LncRNA evf-2 Exacerbates Podocyte Injury in Diabetic Nephropathy by Inducing Cell-Cycle Reentry and Inflammation through Distinct Mechanisms Triggered by Heterogeneous Nuclear Ribonucleoprotein U (hnRNPU)
Authors: Jia Guo, Chaojie Zhang, Zhangsuo Liu
Journal: Journal of the American Society of Nephrology (2024)
Association between Weight Change and Estimated Glomerular Filtration Rate Decline in a Middle-Aged Population
Authors: Niloofar Deravi, Azra Ramezankhani, Mohammad Rahmanian, Parto Hadaegh, Alireza Esteghamati, Fereidoun Azizi, Farzad Hadaegh
Journal: Journal of the American Society of Nephrology (2024)
Single-Cell Profiling of Peripheral Blood Mononuclear Cell Identifies Immune Populations Associated with Progression of Diabetic Kidney Disease
Authors: Jia Fu, Zeguo Sun, Huei Hsun Wen, Dongyuan Chang, Gohar Mosoyan, Kyung Lee, Steven G. Coca, Girish N. Nadkarni, John Cijiang He
Journal: Journal of the American Society of Nephrology (2024)
Palliative Care and Hospice Utilization in US Veterans Treated with Conservative Management vs. Dialysis
Authors: Yoko Narasaki, Connie Rhee, Amy Seungsook You, Man Kit Michael Siu, Csaba P. Kovesdy, Ji Hoon Yoon, Lisa Le, Danh V. Nguyen, Kamyar Kalantar-Zadeh
Journal: Journal of the American Society of Nephrology (2024)
Transcriptomic Analysis of mRNA Expression in Peripheral White Blood Cells of Genes Encoding Circulating Proteins Associated with the Development of ESKD in Diabetes
Authors: Marcus G. Pezzolesi, Katsuhito Ihara, Eiichiro Satake, Zaipul Md Dom, Bozena Krolewski, Andrzej S. Krolewski
Journal: Journal of the American Society of Nephrology (2024)
Delayed Graft Function among Simultaneous Pancreas-Kidney Transplant Recipients Is Associated with an Increased Risk of Urinary Tract Infections and Kidney Rejections
Authors: Sofia Nehring Firmino, Ekaterina Fedorova, Eman Alshaikh, Dixon Kaufman, Jon S. Odorico, Didier A. Mandelbrot, Brad C. Astor, Sandesh Parajuli
Journal: Journal of the American Society of Nephrology (2024)
Drug (Carfilzomib)-Induced Atypical Hemolytic Uremic Syndrome (aHUS)
Authors: Fnu Pariya, Sandeep Raja Sasidharan, Tahir Ahmed Jatoi, Muhammad Azhar, Isha Puri, Mary C. Mallappallil, Mohammad Waleed Abushawer
Journal: Journal of the American Society of Nephrology (2024)
Increased Blood Pressure in Mice with Impaired Function of Afferent Renal Nerves Due to Lack of Sodium Nav1.8 Channels
Authors: Kristina Rodionova, Eva Hutter, Tilmann Ditting, Nada Cordasic, Karl F. Hilgers, Peter Linz, Mario Schiffer, Roland E. Schmieder, Kerstin U. Amann, Roland Veelken
Journal: Journal of the American Society of Nephrology (2024)
Comparison of Estimated Glomerular Filtration Rate in Mexican Kidney Transplant Recipients
Authors: Samantha Isabel Verdugo, Milagros Melissa Flores Fonseca, Alejandro Garcia-Rivera, Omar Humberto Sanchez-Vazquez, Luis Agustín Camacho-Murillo, Sandra Fabiola Velasco
Journal: Journal of the American Society of Nephrology (2024)
Prognostic Value of Secretoneurin in Patients Treated with Chronic Hemodialysis
Authors: Caroline H. Liboriussen, Louis Nygaard, Magnus N. Lyngbakken, Jens Dam Jensen, Rie Io Glerup, Torbjorn Omland, Helge Rosjo, My Svensson
Journal: Journal of the American Society of Nephrology (2024)
Stopping Eculizumab Treatment Safely in Atypical Haemolytic Uraemic Syndrome (SETS aHUS): A Multicentre, Open-Label, Prospective, Single-Arm Trial of the Safety and Impact of Eculizumab Withdrawal
Authors: Neil S. Sheerin, Sally A. Johnson, Edwin Kwan Soon Wong, Luke Vale, Michal Malina, Giovany Orozco Leal, Ciara Anne-Marie Kennedy, Sarah Dunn, David Kavanagh
Journal: Journal of the American Society of Nephrology (2024)
Identification of Kidney Cell Types in Single-Cell RNA Sequencing and Single-Nucleus RNA Sequencing Data Using Machine-Learning Algorithms
Authors: Siddharth S. Madapoosi, Adam Tisch, Stephen A. Blough, Jan S. Rosa, Sean Eddy, Abhijit S. Naik, Christine P. Limonte, Phillip J. McCown, Rajasree Menon, Sylvia E. Rosas, Chirag R. Parikh, Laura H. Mariani, Matthias Kretzler, Ahmed Mahfouz, Fadhl Alakwaa
Journal: Journal of the American Society of Nephrology (2024)
Quantitative Image Analysis Reveals the Benefits of Dapagliflozin on Glomerulosclerosis, Podocyte Effacement, and Kidney Fibrosis in the Spontaneously Diabetic Torii (SDT) Fatty Rat Model of Diabetic Nephropathy
Authors: Francois Briand, Estelle Grasset, Masami Shinohara, Nicole Endlich, Vedran Drenic, Li Chen, Mathieu M. Petitjean, Blazej Dolicki, Thomas De Bel, Yasushi Kageyama, Thierry Sulpice
Journal: Journal of the American Society of Nephrology (2024)
Association of Serum Uric Acid with Podocyte Injury and Kidney Histopathologic Lesions
Authors: Sophia H. Rosan, Ashish Verma, Sophie E. Claudel, Ragnar Palsson, Anand Srivastava, Tobias B. Huber, Isaac Ely Stillman, Joel M. Henderson, Sushrut S. Waikar, Insa Marie Schmidt
Journal: Journal of the American Society of Nephrology (2024)
The Molecular Classification of Pheochromocytomas and Paragangliomas: Discovering the Genomic and Immune Landscape of Metastatic Disease
Authors: Carolijn J. M. de Bresser, Ronald R. de Krijger
Journal: Endocrine Pathology (2024)

Abstract Pheochromocytomas (PCCs) and paragangliomas (PGLs, together PPGLs) are the most hereditary tumors known. PPGLs were considered benign, but the fourth edition of the World Health Organisation (WHO) classification redefined all PPGLs as malignant neoplasms with variable metastatic potential. The metastatic rate differs based on histopathology, genetic background, size, and location of the tumor. The challenge in predicting metastatic disease lies in the absence of a clear genotype–phenotype correlation among the more than 20 identified genetic driver variants. Recent advances in molecular clustering based on underlying genetic alterations have paved the way for improved cluster-specific personalized treatments. However, despite some clusters demonstrating a higher propensity for metastatic disease, cluster-specific therapies have not yet been widely adopted in clinical practice. Comprehensive genomic profiling and transcriptomic analyses of large PPGL cohorts have identified potential new biomarkers that may influence metastatic potential. It appears that no single biomarker alone can reliably predict metastatic risk; instead, a combination of these biomarkers may be necessary to develop an effective prediction model for metastatic disease. This review evaluates current guidelines and recent genomic and transcriptomic findings, with the aim of accurately identifying novel biomarkers that could contribute to a predictive model for mPPGLs, thereby enhancing patient care and outcomes.
Inhaled Reliever Therapies for Asthma
Authors: Daniel G. Rayner, Dario M. Ferri, Gordon H. Guyatt, Paul M. O’Byrne, Romina Brignardello-Petersen, Farid Foroutan, Bradley Chipps, Kaharu Sumino, Tamara T. Perry, Sharmilee Nyenhuis, John Oppenheimer, Elliot Israel, Flavia Hoyte, Katherine Rivera-Spoljaric, Ellen McCabe, Susana Rangel, Lindsay E. Shade, Valerie G. Press, Lisa Hall, Dia Sue-Wah-Sing, Angel Melendez, Hilarry Orr, Tonya Winders, Donna D. Gardner, Kathyrn Przywara, Matthew A. Rank, Leonard B. Bacharier, Giselle Mosnaim, Derek K. Chu
Journal: JAMA (2024)

The optimal inhaled reliever therapy for asthma remains unclear.
The foam cell-derived exosomal miRNA Novel-3 drives neuroinflammation and ferroptosis during ischemic stroke
Authors: Chuan Qin, Ming-Hao Dong, Yue Tang, Yun-Hui Chu, Luo-Qi Zhou, Hang Zhang, Sheng Yang, Lu-Yang Zhang, Xiao-Wei Pang, Li-Fang Zhu, Wei Wang, Dai-Shi Tian
Journal: Nature Aging (2024)
Impaired striatal glutathione–ascorbate metabolism induces transient dopamine increase and motor dysfunction
Authors: Mohd Yaseen Malik, Fei Guo, Aman Asif-Malik, Vasileios Eftychidis, Nikolaos Barkas, Elena Eliseeva, Kerstin N. Timm, Aleksandra Wolska, David Bergin, Barbara Zonta, Veronika Ratz-Wirsching, Stephan von Hörsten, Mark E. Walton, Peter J. Magill, Claus Nerlov, Liliana Minichiello
Journal: Nature Metabolism (2024)

Abstract Identifying initial triggering events in neurodegenerative disorders is critical to developing preventive therapies. In Huntington’s disease (HD), hyperdopaminergia—probably triggered by the dysfunction of the most affected neurons, indirect pathway spiny projection neurons (iSPNs)—is believed to induce hyperkinesia, an early stage HD symptom. However, how this change arises and contributes to HD pathogenesis is unclear. Here, we demonstrate that genetic disruption of iSPNs function by Ntrk2/Trkb deletion in mice results in increased striatal dopamine and midbrain dopaminergic neurons, preceding hyperkinetic dysfunction. Transcriptomic analysis of iSPNs at the pre-symptomatic stage showed de-regulation of metabolic pathways, including upregulation of Gsto2 , encoding glutathione S-transferase omega-2 (GSTO2). Selectively reducing Gsto2 in iSPNs in vivo effectively prevented dopaminergic dysfunction and halted the onset and progression of hyperkinetic symptoms. This study uncovers a functional link between altered iSPN BDNF-TrkB signalling, glutathione–ascorbate metabolism and hyperdopaminergic state, underscoring the vital role of GSTO2 in maintaining dopamine balance.
Leptin in humans: Evidence from clinical studies and current and future clinical applications
Authors: Nikolaos Perakakis, Christos S Mantzoros
Journal: Metabolism (2024)

Leptin has been established as the prototype adipose tissue secreted hormone and as a major regulator of several human physiology functions. Here, we are primarily reviewing the findings from studies in humans involving leptin administration. We are describing the metabolic, endocrine and immunologic effects of leptin replacement in conditions of leptin deficiency, such as short-term fasting in healthy individuals, relative energy deficiency in sports (REDS), congenital leptin deficiency (CLD), generalized (GL) and partial lipodystrophy (PL), HIV-associated lipodystrophy (HIV-L) and of leptin treatment in conditions of leptin excess (common obesity, type 2 diabetes, steatotic liver disease). We are comparing the results with the findings from preclinical models and present the main conclusions regarding the role of leptin in human physiology, pathophysiology and therapeutics. We conclude that, in conditions of energy deficiency, leptin substitution effectively reduces body weight and fat mass through reduction of appetite, it improves hypertriglyceridemia, insulin resistance and hepatic steatosis (especially in GL and PL), it restores neuroendocrine function (especially the gonadotropic axis), it regulates adaptive immune system cell populations and it improves bone health. On the contrary, leptin treatment in conditions of leptin excess, such as common obesity and type 2 diabetes, does not improve any metabolic abnormalities. Strategies to overcome leptin tolerance/resistance in obesity and type 2 diabetes have provided promising results in animal studies, which should though be tested in humans in randomized clinical trials.
Obesity-dependent selection of driver mutations in cancer
Authors: Cerise Tang, Venise Jan Castillon, Michele Waters, Chris Fong, Tricia Park, Sonia Boscenco, Susie Kim, Kelly Pekala, Jian Carrot-Zhang, A. Ari Hakimi, Nikolaus Schultz, Irina Ostrovnaya, Alexander Gusev, Justin Jee, Ed Reznik
Journal: Nature Genetics (2024)

Obesity is a risk factor for cancer, but whether obesity is linked to specific genomic subtypes of cancer is unknown. We examined the relationship between obesity and tumor genotype in two clinicogenomic corpora. Obesity was associated with specific driver mutations in lung adenocarcinoma, endometrial carcinoma and cancers of unknown primaries, independent of clinical covariates, demographic factors and genetic ancestry. Obesity is therefore a driver of etiological heterogeneity in some cancers. Analysis of pan-cancer clinical genomic sequencing finds that body mass index associates with driver mutations in certain cancer types, including most prominently lung adenocarcinoma. Obesity may thus influence tumor genetics.
Advances in body composition and gender differences in susceptibility to frailty syndrome: Role of osteosarcopenic obesity
Authors: Rosy Conforto, Valeria Rizzo, Raffaella Russo, Elisa Mazza, Samantha Maurotti, Carmelo Pujia, Elena Succurro, Franco Arturi, Yvelise Ferro, Angela Sciacqua, Arturo Pujia, Tiziana Montalcini
Journal: Metabolism (2024)
Validation and refinement of the 2022 European LeukaemiaNet genetic risk classification of acute myeloid leukaemia patients receiving allogeneic haematopoietic cell transplantation
Authors: Weihao Chen, Lieguang Chen, Yang Cao, Chuanhe Jiang, Yi Luo, Guifang Ouyang, Jian Yu, Yamin Tan, Xiaoyu Lai, Lizhen Liu, Huarui Fu, Yishan Ye, Luxin Yang, Congxiao Zhang, Jimin Shi, Xiaoxia Hu, He Huang, Yanmin Zhao
Journal: Leukemia (2024)
Ernest Arenas (1962–2024)
Authors: Patrik Ernfors, Gonçalo Castelo-Branco, Per Uhlén, Sten Linnarsson, Ulrika Marklund, Jens Hjerling-Leffler, Onur Dagliyan
Journal: Nature Neuroscience (2024)

Ernest Arenas, Professor at the Karolinska Institutet, passed away on 15 September 2024 at the age of 62 in Stockholm, Sweden. Ernest made unique contributions to the field of Parkinson's disease research, with a strong commitment to developing improved treatment strategies through cell replacement therapy.
When combinations of humans and AI are useful: A systematic review and meta-analysis
Authors: Michelle Vaccaro, Abdullah Almaatouq, Thomas Malone
Journal: Nature Human Behaviour (2024)

Abstract Inspired by the increasing use of artificial intelligence (AI) to augment humans, researchers have studied human–AI systems involving different tasks, systems and populations. Despite such a large body of work, we lack a broad conceptual understanding of when combinations of humans and AI are better than either alone. Here we addressed this question by conducting a preregistered systematic review and meta-analysis of 106 experimental studies reporting 370 effect sizes. We searched an interdisciplinary set of databases (the Association for Computing Machinery Digital Library, the Web of Science and the Association for Information Systems eLibrary) for studies published between 1 January 2020 and 30 June 2023. Each study was required to include an original human-participants experiment that evaluated the performance of humans alone, AI alone and human–AI combinations. First, we found that, on average, human–AI combinations performed significantly worse than the best of humans or AI alone (Hedges’ g = −0.23; 95% confidence interval, −0.39 to −0.07). Second, we found performance losses in tasks that involved making decisions and significantly greater gains in tasks that involved creating content. Finally, when humans outperformed AI alone, we found performance gains in the combination, but when AI outperformed humans alone, we found losses. Limitations of the evidence assessed here include possible publication bias and variations in the study designs analysed. Overall, these findings highlight the heterogeneity of the effects of human–AI collaboration and point to promising avenues for improving human–AI systems.
Intergenerational persistence of poverty in five high-income countries
Authors: Zachary Parolin, Rafael Pintro-Schmitt, Gøsta Esping-Andersen, Peter Fallesen
Journal: Nature Human Behaviour (2024)

Childhood poverty increases the likelihood of adult poverty. However, past research offers conflicting accounts of cross-national variation in the strength of—and mechanisms underpinning—the intergenerational persistence of poverty. Here the authors investigate differences in intergenerational poverty in the United States, Australia, Denmark, Germany and the United Kingdom using administrative- and survey-based panel datasets. Intergenerational poverty is decomposed into family background effects, mediation effects, tax and transfer insurance effects and a residual poverty penalty. The intergenerational persistence of poverty is 0.43 in the United States (95% confidence interval (CI) = 0.40–0.46; P < 0.001), compared with 0.16 in the United Kingdom (95% CI = 0.07–0.25; P < 0.001) and 0.08 in Denmark (95% CI = 0.08–0.08; P < 0.001). The US disadvantage is not channelled through family background, mediators, neighbourhood effects or racial or ethnic discrimination. Instead, the United States has comparatively weak tax and transfer insurance effects and a more severe residual poverty penalty. If the United States were to adopt the tax and transfer insurance effects of its peer countries, its intergenerational poverty persistence could decrease by more than one-third. Children born in poverty are more likely to experience poverty as adults, but this likelihood is greater in the United States than in Australia, Denmark, Germany or the United Kingdom. The authors examine what mediates the differences in intergenerational poverty between countries.