tbuckley/cabot-search huggingface dataset:
Consensus Statement for Protocols of Factorial Randomized Trials
Authors: Brennan C. Kahan, Sophie S. Hall, Elaine M. Beller, Megan Birchenall, Diana Elbourne, Edmund Juszczak, Paul Little, John Fletcher, Robert M. Golub, Beatriz Goulao, Sally Hopewell, Nazrul Islam, Merrick Zwarenstein, An-Wen Chan, Alan A. Montgomery
Journal: JAMA Network Open (2023)

Importance Trial protocols outline a trial’s objectives as well as the methods (design, conduct, and analysis) that will be used to meet those objectives, and transparent reporting of trial protocols ensures objectives are clear and facilitates appraisal regarding the suitability of study methods. Factorial trials, in which 2 or more interventions are assessed in the same set of participants, have unique methodological considerations. However, no extension of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 Statement, which provides guidance on reporting of trial protocols, for factorial trials is available. Objective To develop a consensus-based extension to the SPIRIT 2013 Statement for factorial trials. Evidence Review The SPIRIT extension for factorial trials was developed using the Enhancing the Quality and Transparency of Health Research (EQUATOR) methodological framework. First, a list of reporting recommendations was generated using a scoping review of methodological articles identified using a MEDLINE search (inception to May 2019), which was supplemented with relevant articles from the personal collections of the authors. Second, a 3-round Delphi survey (January to June 2022, completed by 104 panelists from 14 countries) was conducted to assess the importance of items and identify additional recommendations. Third, a hybrid consensus meeting was held, attended by 15 panelists to finalize selection and wording of the checklist. Findings This SPIRIT extension for factorial trials modified 9 of the 33 items in the SPIRIT 2013 checklist. Key reporting recommendations were that the rationale for using a factorial design should be provided, including whether an interaction is hypothesized; the treatment groups that will form the main comparisons should be identified; and statistical methods for each main comparison should be provided, including how interactions will be assessed. Conclusions and Relevance In this consensus statement, 9 factorial-specific items were provided that should be addressed in all protocols of factorial trials to increase the trial’s utility and transparency.
Primary HPV Screening vs Cotesting for Cervical Cancer—Reply
Authors: Rebecca B. Perkins, Nicolas Wentzensen, Mark Schiffman
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Adults Hospitalized With COVID-19 Pneumonia—Reply
Authors: William G. Powderly, Lisa LaVange, Samuel A. Bozzette
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acceptance and Commitment Therapy Among Informal Caregivers of People With Chronic Health Conditions
Authors: Fen Ye, Jung Jae Lee, Dandan Xue, Doris Sau-fung Yu
Journal: JAMA Network Open (2023)

Importance Although there is substantial evidence to suggest the health benefits of acceptance and commitment therapy (ACT) among informal caregivers of people with chronic health conditions, the great variation in intervention designs among published studies limits its application. Objectives To identify intervention characteristics of ACT that are associated with improved psychological health and to assess the acceptability of ACT among informal caregivers. Data Sources Seven English- and 3 Chinese-language databases without limits on publication dates, the reference lists of previous reviews, and gray literature were searched up to February 2023. Study Selection Randomized clinical trials comparing the effect of ACT vs control groups on improving psychological health among informal caregivers. Data Extraction and Synthesis Two reviewers independently screened searched records and extracted data from eligible studies. Random-effects meta-analysis and mixed-effects metaregression were performed. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline was followed. Main Outcomes and Measures Psychological health outcomes (eg, depressive symptoms) measured by valid measurements and the acceptability of ACT based on identified parameters. Results A total of 29 studies with 2010 participants, published between 2015 and 2023, were identified. ACT showed moderate to large effect sizes for improving psychological health at postintervention assessments (Hedges g range, −0.55 [95% CI, −0.98 to −0.12] to −1.14 [95% CI, −1.83 to −0.45]) and at 1-to-3–month and 4-to-6–month follow-ups (Hedges g range, −0.47 [95% CI, −0.69 to −0.25] to −1.29 [95% CI, −2.33 to −0.24]). Multivariable metaregression analysis regarding intervention characteristics found that ACT delivered in a mixed individual- and group-based format, face-to-face, or through more intervention sessions was associated with greater improvements for experiential avoidance (face-to-face: β = −1.170 [95% CI, −2.020 to −0.319]; number of sessions: β = −0.242 [95% CI, −0.353 to −0.130]), depressive symptoms (mixed delivery format: β = −2.583 [95% CI, −4.845 to −0.321]; face-to-face: β = −1.555 [95% CI, −3.002 to −0.108]), or anxiety symptoms (face-to-face: β = −1.241 [95% CI, −2.337 to −0.146]). In general, ACT had low attrition rates (11%), and participants’ adherence (51%-80%) and satisfactory ratings (72%-95%) lend support to its acceptability. Conclusions and Relevance This systematic review and meta-analysis found that ACT was consistently associated with improvements in psychological health, supporting its application to improve informal care for chronic disease management. This review provides specific details on the design parameters of ACT for achieving greater efficacy.
Treatment of Adults Hospitalized With COVID-19 Pneumonia
Authors: Paul Mathew, Marc Feldmann
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Postoperative radiotherapy omission in selected patients with early breast cancer following preoperative breast MRI (PROSPECT): primary results of a prospective two-arm study
Authors: Gregory Bruce Mann, Anita Rohini Skandarajah, Nicholas Zdenkowski, Janemary Hughes, Allan Park, Dennis Petrie, Karinna Saxby, Sean M Grimmond, Anand Murugasu, Andrew J Spillane, Boon H Chua, Heath Badger, Helen Braggett, Val Gebski, Arlene Mou, John P Collins, Allison K Rose
Journal: The Lancet (2023)
Naltrexone 6 mg once daily versus placebo in women with fibromyalgia: a randomised, double-blind, placebo-controlled trial
Authors: Karin Due Bruun, Robin Christensen, Kirstine Amris, Henrik Bjarke Vaegter, Morten Rune Blichfeldt-Eckhardt, Lars Bye-Møller, Anders Holsgaard-Larsen, Palle Toft
Journal: The Lancet Rheumatology (2023)
Sabatolimab plus hypomethylating agents in previously untreated patients with higher-risk myelodysplastic syndromes (STIMULUS-MDS1): a randomised, double-blind, placebo-controlled, phase 2 trial
Authors: Amer M Zeidan, Kiyoshi Ando, Odile Rauzy, Mehmet Turgut, Ming-Chung Wang, Roberto Cairoli, Hsin-An Hou, Yok-Lam Kwong, Montserrat Arnan, Stef Meers, Vinod Pullarkat, Valeria Santini, Kamel Malek, Flavia Kiertsman, Julie Niolat, Pedro Marques Ramos, Hans D Menssen, Pierre Fenaux, Yasushi Miyazaki, Uwe Platzbecker
Journal: The Lancet Haematology (2023)
Single-port Transvesical Robot-Assisted Simple Prostatectomy: Surgical Technique and Clinical Outcomes
Authors: Roxana Ramos, Ethan Ferguson, Mahmoud Abou Zeinab, Nicolas Soputro, Jaya S. Chavali, Adriana M. Pedraza, Zeyad Schwen, Carter Mikesell, Jihad Kaouk
Journal: European Urology (2023)
Impact of individualized treatment on recovery from fatigue and return to work in survivors of advanced-stage Hodgkin’s lymphoma: results from the randomized international GHSG HD18 trial
Authors: J. Ferdinandus, H. Müller, C. Damaschin, A.S. Jacob, J. Meissner, F. Krasniqi, U. Mey, D. Schöndube, J. Thiemer, S. Mathas, J. Zijlstra, R. Greil, M. Feuring-Buske, J. Markova, J.U. Rüffer, C. Kobe, H.-T. Eich, C. Baues, M. Fuchs, P. Borchmann, K. Behringer
Journal: Annals of Oncology (2023)

Persisting cancer-related fatigue impairs health-related quality of life (HRQoL) and social reintegration in patients with Hodgkin's lymphoma (HL). The GHSG HD18 trial established treatment de-escalation for advanced-stage HL guided by positron emission tomography after two cycles (PET-2) as new standard. Here, we investigate the impact of treatment de-escalation on long-term HRQoL, time to recovery from fatigue (TTR-F), and time to return to work (TTR-W).
Liver Stiffness Measurement and Risk Prediction of Hepatocellular Carcinoma After HCV Eradication in Veterans With Cirrhosis
Authors: Binu V. John, Yangyang Dang, David E. Kaplan, Janice H. Jou, Tamar H. Taddei, Seth A. Spector, Paul Martin, Dustin R. Bastaich, Hann-Hsiang Chao, Bassam Dahman
Journal: Clinical Gastroenterology and Hepatology (2023)
Validation of metastasis-free survival as a surrogate endpoint for overall survival in localized prostate cancer in the era of docetaxel for castration-resistant prostate cancer
Authors: W. Xie, P. Ravi, M. Buyse, S. Halabi, P. Kantoff, O. Sartor, H. Soule, N. Clarke, J. Dignam, N. James, K. Fizazi, S. Gillessen, N. Mottet, L. Murphy, W. Parulekar, H. Sandler, B. Tombal, S. Williams, C.J. Sweeney
Journal: Annals of Oncology (2023)
GDF15 is a major determinant of ketogenic diet-induced weight loss
Authors: Jun Feng Lu, Meng Qing Zhu, Bo Xia, Na Na Zhang, Xiao Peng Liu, Huan Liu, Rui Xin Zhang, Jun Ying Xiao, Hui Yang, Ying Qi Zhang, Xiao Miao Li, Jiang Wei Wu
Journal: Cell Metabolism (2023)
Racial disparities in surgical outcomes after mastectomy in 223 000 female breast cancer patients: a retrospective cohort study
Authors: Samuel Knoedler, Martin Kauke-Navarro, Leonard Knoedler, Sarah Friedrich, Dany Y. Matar, Fortunay Diatta, Vikram G. Mookerjee, Haripriya Ayyala, Mengfan Wu, Bong-Sung Kim, Hans-Guenther Machens, Bohdan Pomahac, Dennis P. Orgill, P. Niclas Broer, Adriana C. Panayi
Journal: International Journal of Surgery (2023)

Background: Breast cancer mortality and treatment differ across racial groups. It remains unclear whether such disparities are also reflected in perioperative outcomes of breast cancer patients undergoing mastectomy. Study Design: We reviewed the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database (2008-2021) to identify female patients who underwent mastectomy for oncological purposes. The outcomes were stratified by five racial groups (white, Black/African American, Asian, American Indian/Alaska Native, and Native Hawaiian/Pacific Islander) and included 30-day mortality, reoperation, readmission, surgical and medical complications, and non-home discharge. Results: The study population included 222,947 patients, 68% (n=151,522) of whom were white, 11% (n=23,987) Black/African American, 5% (n=11,217) Asian, 0.5% (n=1,198) American Indian/Alaska Native, and 0.5% (n=1,018) Native Hawaiian/Pacific Islander. While 136,690 (61%) patients underwent partial mastectomy, 54,490 (24%) and 31,767 (14%) women received simple and radical mastectomy, respectively. Overall, adverse events occurred in 17, 222 (7.7%) patients, the largest portion of which were surgical complications (n=7,246; 3.3%). Multivariable analysis revealed that being of Asian race was protective against perioperative complications (OR=0.71; P &lt;0.001), whereas American Indian/Alaska Native women were most vulnerable to the complication occurrence (OR=1.41; P &lt;0.001). Black/African American patients had a significantly lower risk of medical (OR=0.59; P &lt;0.001) and surgical complications (OR=0.60; P &lt;0.001) after partial and radical mastectomy, respectively, their likelihood of readmission (OR=1.14; P =0.045) following partial mastectomy was significantly increased. Conclusion: We identified American Indian/Alaska Native women as particularly vulnerable to complications following mastectomy. Asian patients experienced the lowest rate of complications in the perioperative period. Our analyses revealed comparable confounder-adjusted outcomes following partial and complete mastectomy between Black and white races. Our findings call for care equalization in the field of breast cancer surgery.
Integrating multidisciplinary perspectives in complex anal fistula management: a blueprint for future research and precision surgery
Authors: Jin Xu, Zubing Mei, Qingming Wang
Journal: International Journal of Surgery (2023)

aDepartment of Anorectal Surgery, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 201900, China bDepartment of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, China cAnorectal Disease Institute of Shuguang Hospital, 201203, Shanghai, China Published online ■ ■ *Corresponding Author. Address: Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine; Department of Anorectal Surgery, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, 181 Youyi Road, 201900, Shanghai, China. E-mail address: [email protected] (Q. Wang). *Corresponding Author. Address: Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Anorectal Disease Institute of Shuguang Hospital, 528 Zhangheng Road, Shanghai 201203, Shanghai, China. E-mail address: [email protected], [email protected] (Z. Mei). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Impact of acute silent ischemic lesions on clinical outcomes of carotid revascularization
Authors: Jie Wang, Tao Wang, Bin Yang, Yanfei Chen, Peng Gao, Yabin Wang, Jian Chen, Fei Chen, Jichang Luo, Renjie Yang, Xiaoli Min, Yan Ma, Liqun Jiao
Journal: International Journal of Surgery (2023)

Background: Previous literature has established an association between acute silent ischemic lesions (ASILs) and elevated susceptibility to future adverse clinical outcomes. The present study endeavors to scrutinize the prognostic significance of pre-procedural ASILs, as detected through diffusion-weighted imaging and apparent diffusion coefficient metrics, in relation to subsequent adverse events—namely, stroke, myocardial infarction, and all-cause death—following carotid revascularization in a cohort of patients with symptomatic carotid stenosis. Materials and Methods: Subjects were extracted from a comprehensive retrospective dataset involving symptomatic carotid stenosis cases that underwent carotid revascularization at a tertiary healthcare institution in China, spanning January 2019 to March 2022. Of the 2,663 initially screened patients (symptomatic carotid stenosis=1,600; asymptomatic carotid stenosis=1,063), a total of 1,172 individuals with symptomatic carotid stenosis were retained for subsequent analysis. Stratification was implemented based on the presence or absence of ASILs. The primary endpoint constituted a composite measure of in-hospital stroke, myocardial infarction, or all-cause death. Both carotid endarterectomy (CEA) and carotid artery stenting (CAS) treatment modalities were individually subjected to propensity score-matched analyses. Results: Among the 584 subjects who underwent CEA, 91 ASIL-positive and 91 ASIL-negative (NASIL) cases were propensity score-matched. Notably, the ASIL cohort demonstrated a statistically significant augmentation in the risk of primary outcomes relative to the NASIL group (10.99% vs. 1.10%; absolute risk difference, 9.89% [95% CI, 3.12%-16.66%]; RR, 10.00 [95% CI, 1.31-76.52]; P =0.01). Similarly, within the 588 CAS-treated patients, 107 ASIL-positive and 107 NASIL cases were matched, revealing a correspondingly elevated risk of primary outcomes in the ASIL group (9.35% vs. 1.87%; absolute risk difference, 7.48% [95% CI, 1.39%-13.56%]; RR, 5.00 [95% CI, 1.12-22.28]; P =0.02). Conclusions: ASILs portend an elevated risk for grave adverse events post-carotid revascularization, irrespective of the specific revascularization technique employed—be it CEA or CAS. Thus, ASILs may serve as a potent biomarker for procedural risk stratification in the context of carotid revascularization.
A commentary on ‘Defining and predicting Textbook Outcomes for Perihilar Cholangiocarcinoma: analysis of factors improving of achievement of desired post-operative outcomes. Retrospective Cohort Study’ – a correspondence
Authors: Jiao-Yang Wang, Yan Jiang, Zhi-Peng Liu, Xian-Yu Yin, Zhi-Yu Chen
Journal: International Journal of Surgery (2023)

Wang, Jiao-Yang BM; Jiang, Yan MD; Liu, Zhi-Peng MD; Yin, Xian-Yu MD; Chen, Zhi-Yu PhD Author Information
Predictors and mortality of new onset postoperative atrial fibrillation after STAAD surgery: a retrospective cohort study
Authors: Dongjie Li, Zhou Fang, Maomao Liu, Haibin Li, Hongjia Zhang, Haiyang Li, Yuyong Liu, Wenjian Jiang
Journal: International Journal of Surgery (2023)

Data on new onset postoperative atrial fibrillation (POAF) after Stanford type A dissection (STAAD) surgery was limited. This study aimed to detect the risk factors for developing POAF after STAAD procedures and the association between POAF and in-hospital mortality.
Successful robotic kidney transplantation for surgeons with no experience in minimally invasive surgery: a single institution experience
Authors: Hyun Jeong Kim, Wooju Jeong, Juhan Lee, Seok Jeong Yang, Jong Soo Lee, Joon Chae Na, Woong Kyu Han, Kyu Ha Huh
Journal: International Journal of Surgery (2023)

Background: Robotic kidney transplantation (RKT) is a novel and welcomed innovation yielding good surgical outcomes. However, data on the feasibility and safety of performing RKT by surgeons with a lack of prior minimally invasive surgery (MIS) experience are limited. The authors aimed to evaluate the surgical and functional results of RKT and present the learning curves (LC) of RKT by a single surgeon with no prior experience in MIS. Materials and methods: This was a retrospective study of all RKT performed between November 2019 and April 2023 at Severance Hospital in Seoul, South Korea. The authors analyzed surgical and functional outcomes, as well as complication rates of RKT in comparison to open kidney transplantation (OKT). The authors evaluated LCs using the cumulative summation method to describe the number of cases associated with the competency of a single surgeon. Results: A total of 50 patients who underwent RKT and 104 patients who underwent OKT were included in this study. In RKT group, the median surgical console time was 193 min (interquartile range, 172–222) and the median vascular anastomoses time was 38 min (35–44). Total operation time was 323 min (290–371) and rewarming time was 62.5 min (56.0–70.0) in RKT group compared to 210 min (190–239) and 25 min (21–30), respectively, in OKT group. Despite extended surgical durations with a robotic technique, both groups had comparable intraoperative and postoperative outcomes, as well as renal function. Estimated blood loss and post-transplant hospital stays were significantly lower in RKT group than in OKT group. LC analysis of RKT by the single surgeon revealed that surgical competence was achieved after 15 cases. Conclusion: Even if surgeons do not have prior experience with MIS, they can rapidly overcome the LC and safely perform RKT with adequate preparation and acquisition of basic robotic surgical techniques.