tbuckley/cabot-search huggingface dataset:
Recent Trends of Bioanalytical Sensors with Smart Health Monitoring Systems: From Materials to Applications
Authors: Thi Sinh Vo, Trung Hoang, Tran Thi Bich Chau Vo, Byounghyun Jeon, Vu Hoang Nguyen, Kyunghoon Kim
Journal: Advanced Healthcare Materials (2024)

Smart biosensors attract significant interest due to real-time monitoring of user health status, where bioanalytical electronic devices designed to detect various activities and biomarkers in the human body have potential applications in physical sign monitoring and health care. Bioelectronics can be well integrated by output signals with wireless communication modules for transferring data to portable devices used as smart biosensors in performing real-time diagnosis and analysis. In this review, the scientific keys of biosensing devices and the current trends in the field of smart biosensors, (functional materials, technological approaches, sensing mechanisms, main roles, potential applications and challenges in health monitoring) will be summarized. Recent advances in the design and manufacturing of bioanalytical sensors with smarter capabilities and enhanced reliability indicate a forthcoming expansion of these smart devices from laboratory to clinical analysis. Therefore, a general description of functional materials and technological approaches used in bioelectronics will be presented after the sections of scientific keys to bioanalytical sensors. A careful introduction to the established systems of smart monitoring and prediction analysis using bioelectronics, regarding the integration of machine-learning-based basic algorithms, will be discussed. Afterward, applications and challenges in development using these smart bioelectronics in biological, clinical, and medical diagnostics will also be analyzed. Finally, the review will conclude with outlooks of smart biosensing devices assisted by machine learning algorithms, wireless communications, or smartphone-based systems on current trends and challenges for future works in wearable health monitoring.
Inter-species Transcriptomic Analysis Reveals a Constitutive Adaptation Against Oxidative Stress for the Highly Virulent <i>Leptospira</i> Species
Authors: Alexandre Giraud-Gatineau, Garima Ayachit, Cecilia Nieves, Kouessi C Dagbo, Konogan Bourhy, Francisco Pulido, Samuel G Huete, Nadia Benaroudj, Mathieu Picardeau, Frédéric J Veyrier
Journal: Molecular Biology and Evolution (2024)

Abstract Transcriptomic analyses across large scales of evolutionary distance have great potential to shed light on regulatory evolution but are complicated by difficulties in establishing orthology and limited availability of accessible software. We introduce here a method and a graphical user interface wrapper, called Annotator-RNAtor, for performing interspecies transcriptomic analysis and studying intragenus evolution. The pipeline uses third-party software to infer homologous genes in various species and highlight differences in the expression of the core-genes. To illustrate the methodology and demonstrate its usefulness, we focus on the emergence of the highly virulent Leptospira subclade known as P1+, which includes the causative agents of leptospirosis. Here, we expand on the genomic study through the comparison of transcriptomes between species from P1+ and their related P1- counterparts (low-virulent pathogens). In doing so, we shed light on differentially expressed pathways and focused on describing a specific example of adaptation based on a differential expression of PerRA-controlled genes. We showed that P1+ species exhibit higher expression of the katE gene, a well-known virulence determinant in pathogenic Leptospira species correlated with greater tolerance to peroxide. Switching PerRA alleles between P1+ and P1- species demonstrated that the lower repression of katE and greater tolerance to peroxide in P1+ species was solely controlled by PerRA and partly caused by a PerRA amino-acid permutation. Overall, these results demonstrate the strategic fit of the methodology and its ability to decipher adaptive transcriptomic changes, not observable by comparative genome analysis, that may have been implicated in the emergence of these pathogens.
A commentary on ‘Neoadjuvant intensity modulated radiotherapy for a single and small (≤5 cm) hepatitis B virus-related hepatocellular carcinoma predicted to have high risks of microvascular invasion: a randomized clinical trial’
Authors: Tao He, Jieyu Zou, Ke Sun
Journal: International Journal of Surgery (2024)

aDepartment of Hepatobiliary Surgery bDepartment of Oncology, Chengdu Second People's Hospital, Chengdu, Sichuan, People's Republic of China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Hepatobiliary Surgery, Chengdu Second People's Hospital, No. 10 Qingyun South Street, Chengdu 610021, People's Republic of China. Tel.: +86 15184302720. E-mail: [email protected] (T. He). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
A commentary on “Core decompression combined with platelet-rich plasma-augmented bone grafting for femur head necrosis: a systematic review and meta-analysis”
Authors: Zhe Shen, Yawen He, Lianguo Wu
Journal: International Journal of Surgery (2024)

aThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China bHangzhou Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China cDepartment of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang,People's Republic of China Zhe Shen and Yawen He contributed equally to this work and share first authorship. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: The Second Affiliated Hospital of Zhejiang Chinese Medical University, 318 Chaowang Road, Gongshu District, Hangzhou, Zhejiang 310005, People's Republic of China. E-mail address: [email protected] (L. Wu). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Management of traumatic brain injury in Africa: Challenges and opportunities
Authors: Abdulbasit Opeyemi Muili, Piel Panther Kuol, Afnan W.M Jobran, Ridwanullah Ajedamola Lawal, Ahmed Amaar Agamy, Nourou Dine Adeniran Bankole
Journal: International Journal of Surgery (2024)

Traumatic brain injury (TBI) is a major public health concern globally, with significant implications for morbidity, mortality, and long-term disability. While extensive research has been conducted on TBI management in high-income countries, limited attention has been given to the specific challenges and opportunities faced by healthcare systems in sub-Saharan Africa (SSA). This perspective study aims to provide a comprehensive overview of the current status of TBI management in SSA, focusing on the unique challenges and potential opportunities for improvement. The findings highlight several key challenges faced by SSA healthcare systems in managing TBIs, including limited resources, inadequate infrastructure, and a shortage of trained healthcare professionals. Furthermore, social and cultural factors, such as ignorance of driving laws, financial constraints, and limited access to modern technology services. However, the study also identifies potential opportunities for improving TBI management in SSA. These include strengthening healthcare infrastructure, enhancing pre-hospital care and transportation systems, and increasing public awareness and education about TBI. This perspective study emphasizes the urgent need for tailored interventions and strategies to address the unique challenges faced by SSA in managing TBIs. Addressing the challenges and opportunities in brain injury management in SSA requires a comprehensive approach which can be through investing in health infrastructure, addressing socio-economic inequalities, implementing prevention strategies, and fostering evidence-based research collaboration. Through this, the region can significantly improve TBI care and outcomes, thereby improving the well-being of people affected by TBI in SSA.
Cholecystectomy and ERCP in pregnancy: a nationwide register-based study
Authors: Yiyang Chen
Journal: International Journal of Surgery (2024)

Shenzhen Xinhua Hospital, Peking University, Shenzhen, People's Republic of China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Shenzhen Xinhua Hospital, Peking University, Shenzhen, People's Republic of China. E-mail: [email protected] (Y. Chen). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
What are the key points of bibliometrics?
Authors: Xincheng Li, Guosong Li, Jie Huang
Journal: International Journal of Surgery (2024)

aDepartment of Hepatobiliary Surgery,the Second Hospital of Baoshan city, Baoshan 67800, China bDepartment of Hepatobiliary Surgery,the Second Hospital of Baoshang city, Baoshan 67800, China cDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan, 243 Dianmian Avenue,Wuhua District, Kunming city, Yunnan,China,650101, fax numbers:+86-087165351281. E-mail address: [email protected] (J. Huang). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Prognostic significance of circulating tumor DNA in urothelial carcinoma: a systematic review and meta-analysis
Authors: Haoyang Liu, Junru Chen, Yuchen Huang, Yaowen Zhang, Yuchao Ni, Nanwei Xu, Fengnian Zhao, Yanfeng Tang, Haolin Liu, Guangxi Sun, Pengfei Shen, Zhenhua Liu, Jin Huang, Banghua Liao, Hao Zeng
Journal: International Journal of Surgery (2024)

Circulating tumor DNA (ctDNA) has emerged as a noninvasive technique that provides valuable insights into molecular profiles and tumor disease management. This study aimed to evaluate the prognostic significance of circulating tumor DNA (ctDNA) in urothelial carcinoma (UC) through a systematic review and meta-analysis.
Pancreatic cancer: new approaches to drug therapy
Authors: Vincent J. Picozzi
Journal: International Journal of Surgery (2024)

Outcomes in pancreatic ductal adenocarcinoma (PDAC) remain poor due to a variety of biological, clinical, and societal factors. However, in recent years, PDAC has seen 1) increased precision of initial evaluation, 2) increased emphasis on supportive care, 3) deeper understanding of the translation biology of PDAC, especially as pertains to genomic alterations, and 4) foundational combination chemotherapy clinical trials across all disease stages. These advances have led to a wide range of new approaches to drug therapy for PDAC. Currently available drugs are showing added benefit, both by resequencing them with each other and also with respect to other therapeutic modalities. Molecular strategies are being developed to predict response to known therapeutic agents and to identify others. Additionally, a wide range of new drugs for PDAC are under development, including drugs which inhibit critical molecular pathways, drugs which attempt to capitalize on homologous repair deficiencies, immunotherapeutic approaches, antimetabolic agents, and drugs which attack the extracellular matrix which supports PDAC growth. These new approaches offer the promise of improved survival for future PDAC patients.
Flexible solutions for tiny airways: hydrogels in treating pediatric tracheomalacia
Authors: Areeba Fareed, Rima Siblini, Zeina Rammal, Dima Siblini
Journal: International Journal of Surgery (2024)

aKarachi Medical and Dental College, North Nazimabad, Karachi, Pakistan bFaculty of Medical Sciences, Lebanese University, Beirut, Lebanon Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding Author. Address: The Lebanese University, Faculty of Medical Sciences, LEBANON. E-mail address: [email protected] (R. Siblini). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
A commentary on ‘identification of the consistently differential expressed hub mRNAs and proteins in lung adenocarcinoma and construction of the prognostic signature: a multidimensional analysis’
Authors: Jospin Sindya, Elumalai Perumal, Krishnamoorthy Gunasekaran
Journal: International Journal of Surgery (2024)

aCancer Genomics Laboratory, Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 602105, India bDepartment of Medical Biochemistry, College of Health Sciences, Dambi Dollo University, P. O. Box:360, Kelam Welega Zone, Oromia Region, Ethiopia Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Medical Biochemistry, College of Health Sciences, Dambi Dollo University, P. O. Box:360, Kelam Welega Zone, Oromia Region, Ethiopia. Tel: +251-0575552436. E-mail address: [email protected] (K. Gunasekaran). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
A commentary on ‘Regional differences in bone mineral density biomechanically induce a higher risk of adjacent vertebral fracture after percutaneous vertebroplasty’
Authors: Chuanliang Chen, Xiaochong Zou, Mingyang Jiang, Ke Zhang, Ruqiong Wei
Journal: International Journal of Surgery (2024)

Chen, Chuanliang; Zou, Xiaochong; Jiang, Mingyang; Zhang, Ke; Wei, Ruqiong Author Information
A commentary on ‘Updated disease distributions, risk factors, and trends of laryngeal cancer: a global analysis of cancer registries’
Authors: Zhongliang Fu, Jiajia Lv
Journal: International Journal of Surgery (2024)

aDepartment of Otorhinolaryngology, The People's Hospital of Liaoning Province bDepartment of Otorhinolaryngology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Otorhinolaryngology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, People's Republic of China. E-mail: [email protected] (J. Lv). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Comparative analysis of holmium: YAG laser internal urethrotomy versus Cold-Knife optical internal urethrotomy in the management of urethral stricture: A systematic review and Meta-Analysis
Authors: Junpeng Chi, Keyuan Lou, Guoyan Feng, Shizhang Song, Youyi Lu, Jitao Wu, Yuanshan Cui
Journal: International Journal of Surgery (2024)

Objective: Urethral stricture management has posed enduring challenges in urology, demanding innovative and effective treatment modalities. This study addresses the persistent issues associated with urethral strictures, focusing on the comparative evaluation of two contemporary treatment modalities: Ho: YAG Laser Internal Urethrotomy (HIU) and Cold Knife Optical Internal Urethrotomy (CIU). Methods: A comprehensive search of PubMed, Embase, Web of Science, Cochrane Library and ResearchGate was conducted to identify relevant studies up to November 2023. Inclusion criteria encompassed comparative studies evaluating HIU and CIU in patients with urethral stricture. Data extraction, quality assessment, and subgroup analyses were performed using standardized methods. Outcome measures included preoperative and postoperative mean the maximum urine flow rate (Qmax), mean surgical time, recurrence rates, and perioperative complications. Results: Nine articles met the inclusion criteria, and their data were analyzed using RevMan 5.4.1. Forest plots were generated for preoperative and postoperative mean Qmax, mean surgical time, recurrence rates, and perioperative complications. While postoperative mean Qmax (MD -0.06; 95% CI, -0.28–0.16; P =0.60, I 2 =75%) and mean surgical time (MD 2.16; 95% CI, -1.66–5.99; P =0.27, I 2 =98%) showed no significant differences between HIU and CIU, a trend towards lower recurrence rates (RR 0.71; 95% CI, 0.48–1.06; P =0.09, I 2 =46%) was observed with HIU but without statistical significance. Perioperative complications, particularly bleeding (RR 0.21; 95% CI, 0.08–0.53; P =0.001, I 2 =0%), favored HIU over CIU. The subanalysis indicates that for the treatment of complex urethral strictures, the two surgical methods differ in terms of mean Qmax at 6 months postoperatively (MD -2.51; 95% CI, -4.10–-0.91; P =0.002, I 2 =59%) and 12 months postoperatively (MD 2.62; 95% CI, 0.93–4.30; P =0.002, I 2 =0%). The HIU group shows a significant decrease in recurrence rate at 12 months postoperatively (RR 0.44; 95% CI, 0.21–0.92; P =0.03, I 2 =0%). For short-segment urethral strictures with a length ≤1.5 cm, CIU had a shorter operative time compared to the HIU (MD 4.49; 95% CI, 3.87–5.10; P &lt;0.00001, I 2 =44%). Conclusion: Overall, both interventions demonstrated similar efficacy in improving postoperative mean Qmax, mean surgical time and recurrence rates. However, subanalysis indicates that in the short term, CIU is more effective than HIU in improving Qmax after complex urethral stricture surgery. In long-term Qmax follow-up after surgery, HIU is significantly higher than CIU, and HIU has a low recurrence rate. In addition, for short-segment urethral stricture (≤1.5 cm), CIU requires less time. In terms of complications, HIU has a lower risk of bleeding.
Perioperative textbook outcomes of minimally invasive pancreatoduodenectomy: a multicenter retrospective cohort analysis in a Korean minimally invasive pancreatic surgery registry
Authors: Jaewoo Kwon, Chang Moo Kang, Jin-Young Jang, Yoo-Seok Yoon, Hyung Jun Kwon, In Seok Choi, Hee Joon Kim, Sang Hyun Shin, Sang Hyun Kang, Hyung Hwan Moon, Dae Wook Hwang, Song Cheol Kim
Journal: International Journal of Surgery (2024)

Background: The aim of this study is to investigate the perioperative composite textbook outcomes of pancreatic surgery after minimally invasive pancreatoduodenectomy (MIPD). Materials and methods: The cohort study was conducted across 10 institutions and included 1552 patients who underwent MIPD registered with the Korean Study Group on Minimally Invasive Pancreatic Surgery between May 2007 and April 2020. We analyzed perioperative textbook outcomes of pancreatic surgery after MIPD. Subgroup analyses were performed to assess outcomes based on the hospital volume of MIPD. Results: Among all patients, 21.8% underwent robotic pancreatoduodenectomy. High-volume centers (performing &gt;20 MIPD/year) performed 88.1% of the procedures. The incidence of clinically relevant postoperative pancreatic fistula was 11.5%. Severe complications (Clavien–Dindo grade ≥IIIa) occurred in 15.1% of the cases. The 90-day mortality rate was 0.8%. The mean hospital stay was 13.7 days. Textbook outcomes of pancreatic surgery success were achieved in 60.4% of patients, with higher rates observed in high-volume centers than in low-volume centers (62.2% vs. 44.7%, P &lt;0.001). High-volume centers exhibited significantly lower conversion rates (5.4% vs. 12.5%, P =0.001), lower 90-day mortality (0.5% vs. 2.7%, P =0.001), and lower 90-day readmission rates (4.5% vs. 9.6%, P =0.006) than those low-volume centers. Conclusion: MIPD could be performed safely with permissible perioperative outcomes, including textbook outcomes of pancreatic surgery, particularly in experienced centers. The findings of this study provided valuable insights for guiding surgical treatment decisions in periampullary disease.
A commentary on “the safety and efficacy between remimazolam and propofol in intravenous anesthesia of endoscopy operation: a systematic review and meta-analysis”
Authors: Hongxu Ren, Zhaojie Lv, Zijun Liu, Haibo Wang
Journal: International Journal of Surgery (2024)

aDepartment of Operating Room,Yantai Yuhuangding Hospital, Yantai, Shandong, China bDepartment of Anesthesiology, Yantai Yuhuangding Hospital, Yantai, Shandong, China cDepartment of Gastrointestinal Surgery,Yantai Yuhuangding Hospital, Yantai, Shandong, China Co-authors: Hongxu Ren and Zhaojie Lv equally contributed to the article. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Gastrointestinal Surgery,Yantai Yuhuangding Hospital, Yantai, Shandong, China. E-mail address: [email protected] (H. Wang). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/