tbuckley/cabot-search huggingface dataset:
Modifiable parental factors associated with the mental health of youth from immigrant families in high-income countries: A systematic review and meta-analysis
Authors: Sunita Bayyavarapu Bapuji, Ashlyn Hansen, Miriam H. Marembo, Patrick Olivier, Marie Bee Hui Yap
Journal: Clinical Psychology Review (2024)

Parental factors play a major role in youth mental health and many youth in high-income countries have at least one overseas-born parent. It is, hence, important to understand how immigrant parenting is associated with youth mental health in high-income countries. Following PRISMA guidelines, this review sought to identify modifiable parental factors to inform parenting interventions to prevent mental health problems in youth aged 0-18 years whose parents migrated voluntarily for economic reasons from low and middle-income countries to high-income countries. Sixteen parental factors were identified from 56 studies that were associated with five outcomes - youth self-esteem (k = 17), general stress (k = 4), acculturative stress (k = 4), anxiety symptoms (k = 9), and depressive symptoms (k = 41). A sound evidence base was found for one or more of these outcomes associated with protective factors - caring and supportive parenting and parental monitoring; and risk factors - parent-youth acculturative and general conflict, parental withdrawal, interparental conflict, and parent mental health problems. This systematic review and meta-analysis identified immigrant parental factors that have robust associations with youth mental health outcomes. These findings can be used to inform parenting interventions and support immigrant parents in preventing youth mental health problems.
A Mesoporous Silica‐Loaded Multi‐Functional Hydrogel Enhanced Tendon Healing via Immunomodulatory and Pro‐Regenerative Effects
Authors: Renwen Wan, Zhiwen Luo, Xiaoshuang Nie, Xinting Feng, Yanwei He, Fangqi Li, Shan Liu, Wenbo Chen, Beijie Qi, Haocheng Qin, Wei Luo, Hanli Zhang, Hongyi Jiang, Junming Sun, Xuanyong Liu, Qing Wang, Xiliang Shang, Jiajun Qiu, Shiyi Chen
Journal: Advanced Healthcare Materials (2024)

Tendon injuries are pervasive orthopedic injuries encountered by the general population. Nonetheless, recovery after severe injuries, such as Achilles tendon injury, is limited. Consequently, there is a pressing need to devise interventions, including biomaterials, that foster tendon healing. Regrettably, tissue engineering treatments have faced obstacles in crafting appropriate tissue scaffolds and efficacious nanomedical approaches. To surmount these hurdles, an innovative injectable hydrogel (CP@SiO2), comprising puerarin and chitosan through in situ self-assembly, is pioneered while concurrently delivering mesoporous silica nanoparticles for tendon healing. In this research, CP@SiO2 hydrogel is employed for the treatment of Achilles tendon injuries, conducting extensive in vivo and in vitro experiments to evaluate its efficacy. This reults demonstrates that CP@SiO2 hydrogel enhances the proliferation and differentiation of tendon-derived stem cells, and mitigates inflammation through the modulation of macrophage polarization. Furthermore, using histological and behavioral analyses, it is found that CP@SiO2 hydrogel can improve the histological and biomechanical properties of injured tendons. This findings indicate that this multifaceted injectable CP@SiO2 hydrogel constitutes a suitable bioactive material for tendon repair and presents a promising new strategy for the clinical management of tendon injuries.
<scp>SM</scp>17, a new <scp>IL</scp>‐17<scp>RB</scp>‐targeting antibody, ameliorates disease progression in a mouse model of atopic dermatitis
Authors: Lik Hang Lam, Weimin Li, Wai Chung Wu, Kai Cheung Chow, Wai Yin Dennis Au, Guolin Xu, Ge Wang, Xuchen Qian, Ka Man Ng, Shaik Abdullah Nawabjan, Muthu Iswarya Gandhi Sethuraman, Wai Yan Choi, Billy Kwok Chong Chow, Shui On Leung, Chin Wai Hui
Journal: Allergy (2024)

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. Appendix S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Comparison of the 2022 world health organization classification and international consensus classification in myelodysplastic syndromes/neoplasms
Authors: Wan-Hsuan Lee, Chien-Chin Lin, Cheng-Hong Tsai, Feng-Ming Tien, Min-Yen Lo, Mei-Hsuan Tseng, Yuan-Yeh Kuo, Shan-Chi Yu, Ming-Chih Liu, Chang-Tsu Yuan, Yi-Tsung Yang, Ming-Kai Chuang, Bor-Sheng Ko, Jih-Luh Tang, Hsun-I Sun, Yi-Kuang Chuang, Hwei-Fang Tien, Hsin-An Hou, Wen-Chien Chou
Journal: Blood Cancer Journal (2024)

Abstract In 2022, two novel classification systems for myelodysplastic syndromes/neoplasms (MDS) have been proposed: the International Consensus Classification (ICC) and the 2022 World Health Organization (WHO-2022) classification. These two contemporary systems exhibit numerous shared features but also diverge significantly in terminology and the definition of new entities. Thus, we retrospectively validated the ICC and WHO-2022 classification and found that both systems promoted efficient segregation of this heterogeneous disease. After examining the distinction between the two systems, we showed that a peripheral blood blast percentage ≥ 5% indicates adverse survival. Identifying MDS/acute myeloid leukemia with MDS-related gene mutations or cytogenetic abnormalities helps differentiate survival outcomes. In MDS, not otherwise specified patients, those diagnosed with hypoplastic MDS and single lineage dysplasia displayed a trend of superior survival compared to other low-risk MDS patients. Furthermore, the impact of bone marrow fibrosis on survival was less pronounced within the ICC framework. Allogeneic transplantation appears to improve outcomes for patients diagnosed with MDS with excess blasts in the ICC. Therefore, we proposed an integrated system that may lead to the accurate diagnosis and advancement of future research for MDS. Prospective studies are warranted to validate this refined classification.
VRD versus VCD as induction therapy before autologous stem cell transplantation in multiple myeloma: a nationwide population-based study
Authors: Jakob Nordberg Nørgaard, Kari Lenita Falck Moore, Tobias S. Slørdahl, Anders Vik, Tor Henrik Anderson Tvedt, Fredrik Schjesvold
Journal: Blood Cancer Journal (2024)

a Kidney failure: Creatinine > 177 μmol/L or CrCl <40 mL/min.Anemia: Hemoglobin <10 g/dL or >2 g/dL below normal.Osteolytic lesions: one or more osteolytic lesion detected by X-ray, CT or PET-CT.Hypercalcemia: Hypercalcemia: serum calcium >0.25 mmol/L ( > 1 mg/dL) higher than the upper limit of normal or >2.75 mmol/L ( > 11 mg/dL).b ≥60% bone marrow plasma cells, free light chain ratio ≥100 and/or >1 MRI-defined ≥5 mm focal lesion.c High risk cytogenetics was defined as (del(17p), t(4;14) or t(14;16)) VGPR = very good partial response d Patients who had less than 18 months of follow-up were excluded.
A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death
Authors: Arghya Ray, Ting Du, Xueping Wan, Yan Song, Sindhu C. Pillai, Md. Abu Musa, Teng Fang, Jared Moore, Brian Blank, Xiaohui Du, Xi Chen, Robert Warne, Dena Sutimantanapi, Fang Lui, Tatiana Zavorotinskaya, Christophe Colas, Lori Friedman, Melissa R. Junttila, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood Cancer Journal (2024)

A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death
Identification of pyruvic and maleic acid as potential markers for disease activity and prognosis in chronic urticaria
Authors: Xingxing Jian, Guixue Hou, Liqiao Li, Zhuo Diao, Yingfang Wu, Jiayi Wang, Lu Xie, Cong Peng, Liang Lin, Jie Li
Journal: Journal of Allergy and Clinical Immunology (2024)
EphB2 Receptor Promotes Dermal Fibrosis in Systemic Sclerosis
Authors: Erika S. A. Egal, Severin Donald Kamdem, Masaaki Yoshigi, Ching‐Chu Yang, Sarah Pellizzari, Ernest M. Kameni, My N. Helms, Shervin Assassi, Mark Henkemeyer, Tracy M. Frech, Patrice N. Mimche
Journal: Arthritis & Rheumatology (2024)

Erythropoietin-producing hepatocellular (Eph)/Ephrin cell-cell signaling is emerging as a key player in tissue fibrogenesis. The aim of this study was to test the hypothesis that the receptor tyrosine kinase EphB2 mediates dermal fibrosis in systemic sclerosis (SSc).
<scp>A GITRL‐mTORC1‐GM‐CSF Positive Loop</scp> Promotes Pathogenic Th17 Response in Primary Sjögren Syndrome
Authors: Yuzhou Gan, Haotian Zhou, Yixue Guo, Bo Huang, Hongjiang Liu, Ziye Wang, Zijun Li, Xiaozhen Zhao, Huaqun Zhu, Qimao Han, Hua Ye, Jing He, Qingwen Wang, Zhanguo Li, Xiaolin Sun
Journal: Arthritis & Rheumatology (2024)

Glucocorticoid-induced tumor necrosis factor receptor superfamily-related protein (GITR), with its ligand (GITRL), plays an important role in CD4
Using artificial intelligence-based technologies to support the diagnosis and early detection of melanoma in primary care
Authors: Owain T Jones, Rubeta N Matin, Fiona M Walter
Journal: British Journal of Dermatology (2024)

Journal Article Corrected proof Using artificial intelligence-based technologies to support the diagnosis and early detection of melanoma in primary care Get access Owain T Jones, Owain T Jones Writing - original draft, Writing - review & editing Department of Public Health and Primary Care, University of Cambridge, Cambridge Correspondence: Owain T. Jones. Email: otj24@medschl.cam.ac.uk https://orcid.org/0000-0003-2783-9431 Search for other works by this author on: Oxford Academic Google Scholar Rubeta N Matin, Rubeta N Matin Writing - review & editing Department of Dermatology, Churchill Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar Fiona M Walter Fiona M Walter Writing - review & editing Wolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, ljae094, https://doi.org/10.1093/bjd/ljae094 Published: 09 April 2024 Article history Received: 27 February 2024 Corrected and typeset: 09 April 2024 Published: 09 April 2024
Baseline phenotypes with preserved β-cell function and high insulin concentrations have the best improvements in glucose tolerance after weight loss: results from the prospective DEXLIFE and EGIR-RISC studies
Authors: Silvia Sabatini, John J. Nolan, Grainne O'Donoghue, Aileen Kennedy, John Petrie, Mark Walker, Donal J. O'Gorman, Amalia Gastaldelli
Journal: Metabolism (2024)

Weight loss and lifestyle intervention improve glucose tolerance delaying the onset of type 2 diabetes (T2D), but individual responses are highly variable. Determining the predictive factors linked to the beneficial effects of weight loss on glucose tolerance could provide tools for individualized prevention plans. Thus, the aim was to investigate the relationship between pre-intervention values of insulin sensitivity and secretion and the improvement in glucose metabolism after weight loss.
Treatment patterns for AL amyloidosis after frontline daratumumab, bortezomib, cyclophosphamide, and dexamethasone treatment failures
Authors: Saurabh Zanwar, Morie A. Gertz, Eli Muchtar, Francis K. Buadi, Taxiarchis Kourelis, Wilson Gonsalves, Ronald S. Go, Suzanne Hayman, Prashant Kapoor, Moritz Binder, Joselle Cook, David Dingli, Nelson Leung, Yi Lin, Rahma Warsame, Amie Fonder, Miriam Hobbs, Yi Lisa Hwa, Robert A. Kyle, S. Vincent Rajkumar, Shaji Kumar, Angela Dispenzieri
Journal: Leukemia (2024)
A promising future of metal‐<i>N</i>‐heterocyclic carbene complexes in medicinal chemistry: The emerging bioorganometallic antitumor agents
Authors: Qian Zhao, Bo Han, Cheng Peng, Nan Zhang, Wei Huang, Gu He, Jun‐Long Li
Journal: Medicinal Research Reviews (2024)

Abstract Metal complexes based on N ‐heterocyclic carbene (NHC) ligands have emerged as promising broad‐spectrum antitumor agents in bioorganometallic medicinal chemistry. In recent decades, studies on cytotoxic metal–NHC complexes have yielded numerous compounds exhibiting superior cytotoxicity compared to cisplatin. Although the molecular mechanisms of these anticancer complexes are not fully understood, some potential targets and modes of action have been identified. However, a comprehensive review of their biological mechanisms is currently absent. In general, apoptosis caused by metal–NHCs is common in tumor cells. They can cause a series of changes after entering cells, such as mitochondrial membrane potential (MMP) variation, reactive oxygen species (ROS) generation, cytochrome c (cyt c) release, endoplasmic reticulum (ER) stress, lysosome damage, and caspase activation, ultimately leading to apoptosis. Therefore, a detailed understanding of the influence of metal–NHCs on cancer cell apoptosis is crucial. In this review, we provide a comprehensive summary of recent advances in metal–NHC complexes that trigger apoptotic cell death via different apoptosis‐related targets or signaling pathways, including B‐cell lymphoma 2 (Bcl‐2 family), p53, cyt c, ER stress, lysosome damage, thioredoxin reductase (TrxR) inhibition, and so forth. We also discuss the challenges, limitations, and future directions of metal–NHC complexes to elucidate their emerging application in medicinal chemistry.
Human-AI interaction in skin cancer diagnosis: a systematic review and meta-analysis
Authors: Isabelle Krakowski, Jiyeong Kim, Zhuo Ran Cai, Roxana Daneshjou, Jan Lapins, Hanna Eriksson, Anastasia Lykou, Eleni Linos
Journal: npj Digital Medicine (2024)

Abstract The development of diagnostic tools for skin cancer based on artificial intelligence (AI) is increasing rapidly and will likely soon be widely implemented in clinical use. Even though the performance of these algorithms is promising in theory, there is limited evidence on the impact of AI assistance on human diagnostic decisions. Therefore, the aim of this systematic review and meta-analysis was to study the effect of AI assistance on the accuracy of skin cancer diagnosis. We searched PubMed, Embase, IEE Xplore, Scopus and conference proceedings for articles from 1/1/2017 to 11/8/2022. We included studies comparing the performance of clinicians diagnosing at least one skin cancer with and without deep learning-based AI assistance. Summary estimates of sensitivity and specificity of diagnostic accuracy with versus without AI assistance were computed using a bivariate random effects model. We identified 2983 studies, of which ten were eligible for meta-analysis. For clinicians without AI assistance, pooled sensitivity was 74.8% (95% CI 68.6–80.1) and specificity was 81.5% (95% CI 73.9–87.3). For AI-assisted clinicians, the overall sensitivity was 81.1% (95% CI 74.4–86.5) and specificity was 86.1% (95% CI 79.2–90.9). AI benefitted medical professionals of all experience levels in subgroup analyses, with the largest improvement among non-dermatologists. No publication bias was detected, and sensitivity analysis revealed that the findings were robust. AI in the hands of clinicians has the potential to improve diagnostic accuracy in skin cancer diagnosis. Given that most studies were conducted in experimental settings, we encourage future studies to further investigate these potential benefits in real-life settings.
Understanding exosomes: Part 2—Emerging leaders in regenerative medicine
Authors: Richard J. Miron, Nathan E. Estrin, Anton Sculean, Yufeng Zhang
Journal: Periodontology 2000 (2024)

Abstract Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. Today exosomes have been applied in numerous contexts including neurodegenerative disorders (Alzheimer's disease, central nervous system, depression, multiple sclerosis, Parkinson's disease, post‐traumatic stress disorders, traumatic brain injury, peripheral nerve injury), damaged organs (heart, kidney, liver, stroke, myocardial infarctions, myocardial infarctions, ovaries), degenerative processes (atherosclerosis, diabetes, hematology disorders, musculoskeletal degeneration, osteoradionecrosis, respiratory disease), infectious diseases (COVID‐19, hepatitis), regenerative procedures (antiaging, bone regeneration, cartilage/joint regeneration, osteoarthritis, cutaneous wounds, dental regeneration, dermatology/skin regeneration, erectile dysfunction, hair regrowth, intervertebral disc repair, spinal cord injury, vascular regeneration), and cancer therapy (breast, colorectal, gastric cancer and osteosarcomas), immune function (allergy, autoimmune disorders, immune regulation, inflammatory diseases, lupus, rheumatoid arthritis). This scoping review is a first of its kind aimed at summarizing the extensive regenerative potential of exosomes over a broad range of diseases and disorders.
Midfacial toddler excoriation syndrome (MiTES): case series, diagnostic criteria and evidence for a pathogenic mechanism
Authors: Nivedita Sarveswaran, Yunisa Pamela, Akhila A N Reddy, Akash P Mustari, Anchala Parthasarathi, Anthony J Mancini, Anuradha Bishnoi, Arun C Inamadar, Bayanne Olabi, Fiona Browne, Gargi N Deshmukh, Kenneth McWilliam, Keshavamurthy Vinay, Sahana Srinivas, Samantha Ibbs, Sivakumar Natarajan, Vadlamudi R Rao, Vijay Zawar, Vykuntaraju K Gowda, Samiha S Shaikh, Celia Moss, Christopher G Woods, Ichrak Drissi
Journal: British Journal of Dermatology (2024)

PRDM12 polyalanine tract expansions cause two different disorders: midfacial toddler excoriation syndrome (MiTES; itch with normal pain sensation associated with 18 homozygous alanines (18A); and congenital insensitivity to pain (CIP) with normal itch associated with 19 homozygous alanines (19A). Knowledge of the phenotype, genotype and disease mechanism of MiTES is incomplete. Why 18A vs. 19A PRDM12 can cause almost opposite phenotypes is unknown; no other polyalanine or polyglutamine tract expansion disease causes two such disparate phenotypes.
Pathophysiological subtypes of mild cognitive impairment due to Alzheimer’s disease identified by CSF proteomics
Authors: Daniela Moutinho, Vera M. Mendes, Alessandro Caula, Sara C. Madeira, Inês Baldeiras, Manuela Guerreiro, Sandra Cardoso, Johan Gobom, Henrik Zetterberg, Isabel Santana, Alexandre De Mendonça, Helena Aidos, Bruno Manadas
Journal: Translational Neurodegeneration (2024)
High‐Density, Conformable Conducting Polymer‐Based Implantable Neural Probes for the Developing Brain
Authors: Liang Ma, Duncan J. Wisniewski, Claudia Cea, Dion Khodagholy, Jennifer N. Gelinas
Journal: Advanced Healthcare Materials (2024)

Neurologic and neuropsychiatric disorders substantially impact the pediatric population, but there is a lack of dedicated devices for monitoring the developing brain in animal models, leading to gaps in mechanistic understanding of how brain functions emerge and their disruption in disease states. Due to the small size, fragility, and high water content of immature neural tissue, as well as the absence of a hardened skull to mechanically support rigid devices, conventional neural interface devices are poorly suited to acquire brain signals without inducing damage. Here, the authors design conformable, implantable, conducting polymer-based probes (NeuroShanks) for precise targeting in the developing mouse brain without the need for skull-attached, rigid mechanical support structures. These probes enable the acquisition of high spatiotemporal resolution neurophysiologic activity from superficial and deep brain regions across unanesthetized behavioral states without causing tissue disruption or device failure. Once implanted, probes are mechanically stable and permit precise, stable signal monitoring at the level of the local field potential and individual action potentials. These results support the translational potential of such devices for clinically indicated neurophysiologic recording in pediatric patients. Additionally, the role of organic bioelectronics as an enabling technology to address questions in developmental neuroscience is revealed.
Will cellular immunotherapies end neurodegenerative diseases?
Authors: Pavle Boskovic, Wenqing Gao, Jonathan Kipnis
Journal: Trends in Immunology (2024)

Neurodegenerative disorders present major challenges to global health, exacerbated by an aging population and the absence of therapies. Despite diverse pathological manifestations, they share a common hallmark, loosely termed 'neuroinflammation'. The prevailing dogma is that the immune system is an active contributor to neurodegeneration; however, recent evidence challenges this. By analogy with road construction, which causes temporary closures and disruptions, the immune system's actions in the central nervous system (CNS) might initially appear destructive, and might even cause harm, while aiming to combat neurodegeneration. We propose that the application of cellular immunotherapies to coordinate the immune response towards remodeling might pave the way for new modes of tackling the roadblocks of neurodegenerative diseases.
Cognitive behavioral and mindfulness with daily exercise intervention is associated with changes in intestinal microbial taxa and systemic inflammation in patients with Crohn’s disease
Authors: Karny Ilan, Yair Motro, Anna Nemirovsky, Doron Schwartz, Ganit Goren, Ruslan Sergienko, Dan Greenberg, Vered Slonim-Nevo, Orly Sarid, Michael Friger, Shirley Regev, Shmuel Odes, Jacob Moran-Gilad, Alon Monsonego
Journal: Gut Microbes (2024)

Crohn's disease (CD) is a chronic inflammatory bowel disease associated with psychological distress and intestinal microbial changes. Here, we examined whether a 3-month period of Cognitive Behavioral and Mindfulness with Daily Exercise (COBMINDEX) intervention, which improves the wellbeing and inflammatory state of CD patients, may also affect their gut microbiome. Gut microbiota, circulating inflammatory markers and hormones were analyzed in 24 CD patients before (T1) and after 3 months of COBMINDEX (T2), and in 25 age- and sex-matched wait-list control patients at the corresponding time-points. Microbiota analysis examined relative taxonomical abundance, alpha and beta diversity, and microbiome correlations with inflammatory and psychological parameters. At T1, CD patients exhibited a characteristic microbial profile mainly constituted of Proteobacteria (17.71%), Firmicutes (65.56%), Actinobacteria (8.46%) and Bacteroidetes (6.24%). Baseline bacterial abundances showed significant correlations with psychological markers of distress and with IFNγ. Following COBMINDEX, no significant changes in alpha and beta diversity were observed between both study groups, though a trend change in beta diversity was noted. Significant changes occurred in the abundance of phyla, families and genera only among the COBMINDEX group. Furthermore, abundance of phyla, families and genera that were altered following COBMNIDEX, significantly correlated with levels of cytokines and psychological parameters. Our results demonstrated that a short-term intervention of COBMINDEX was associated with changes in microbial indices, some of which are linked to psychological manifestations and systemic inflammation in CD patients. Psychological interventions to reduce chronic stress, such as COBMINDEX, appear to be beneficial in mitigating the pathobiology of CD patients, and may thus provide a useful adjunct to pharmacological therapy.