THE SENSITIVITY TO HYPERTENSIN, ADRENALIN AND RENIN OF UNANESTHETIZED NORMAL, ADRENALECTOMIZED, HYPOPHYSECTOMIZED AND NEPHRECTOMIZED DOGS
Authors: B. A. Houssay, L. Dexter
Journal: Annals of Internal Medicine (1942)

Article1 September 1942THE SENSITIVITY TO HYPERTENSIN, ADRENALIN AND RENIN OF UNANESTHETIZED NORMAL, ADRENALECTOMIZED, HYPOPHYSECTOMIZED AND NEPHRECTOMIZED DOGSB. A. HOUSSAY, M.D., L. DEXTER, M.D.B. A. HOUSSAY, M.D., L. DEXTER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-3-451 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1898 Tigerstedt and Bergmann1discovered a pressor substance in normal kidneys to which they gave the name renin. This substance had a prolonged pressor effect when injected intravenously into animals, successive injections had a diminishing pressor action (tachyphylaxis), and it was not found in organs other than the kidneys. Their findings have been widely confirmed by subsequent investigators. With the development of a method of inducing hypertension experimentally in animals by Goldblatt, Lynch, Hanzal, and Summerville2and with the resultant evidence that this renal hypertension was apparently due to a humoral mechanism,3, 4the rôle played by renin in...Bibliography1. TIGERSTEDTBERGMANN RPG: Niere und Kreislauf, Skand. Arch. f. Physiol., 1898, viii, 223. CrossrefGoogle Scholar2. GOLDBLATTLYNCHHANZALSUMMERVILLE HJRFWW: Studies on experimental hypertension. I. Production of persistent elevation of systolic pressure by means of renal ischemia, Jr. Exper. Med., 1934, lix, 347. CrossrefGoogle Scholar3. GOLDBLATT H: Studies on experimental hypertension. V. The pathogenesis of experimental hypertension due to renal ischemia, ANN. INT. MED., 1937, xi, 69. LinkGoogle Scholar4. FASCIOLO JC: Hipertensión arterial nefrógena; estudio experimental, Tesis Doct. Med., Buenos Aires, 1939. Google Scholar5. KOHLSTAEDTHELMERPAGE KGOMIH: Activation of renin by blood colloids, Proc. Soc. Exper. 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FREEDMAN A: Response to renin of unanesthetized normal and nephrectomized rats, Am. Heart Jr., 1940, xx, 304. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 13, 1941.From the Department of Physiology, Faculty of Medical Sciences, Buenos Aires, Argentina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKidney Enzymes and Essential HypertensionRenin–Angiotensin–Aldosterone System and the Renal Regulation of Sodium, Potassium, and Blood Pressure HomeostasisCorticosteroid Modulation of the Renin System and Blood Pressure in the Spontaneously Hypertensive RatVascular Reactivity to Angiotensin and Noradrenaline in Rats. 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