tbuckley/cabot-search huggingface dataset:
TCTAP C-210 Complex Management of Severe Aortic Stenosis and Multivessel Coronary Artery Disease in a Frail, Small-Stature Patient: Transition From Cardiogenic Shock to Transcarotid TAVR
Authors: Wittawin Wangpermpoon, Thinnakrit Sasiprapha, Tawai Ngernsritrakul, Mann Chandavimol
Journal: Journal of the American College of Cardiology (2025)
TCTAP C-216 A Challenging Case Report: Concomitant M/T TEER in Post Infarct Papillary Muscle Rupture
Authors: Su Min Lim, Senthilraj Thangasami, Antonio Felipe Leite Simao, Bin Wang, Xiang Chen, Xu Chen, Mao Long Su, Yan Wang
Journal: Journal of the American College of Cardiology (2025)
TCTAP C-212 Redo-TAVR in a Patient With Bicuspid Aortic Valve Stenosis and Infective Endocarditis
Authors: Huan Chiu Lin, Chun-Ting Liu, Yung-Tsai Lee, Tien-Ping Tsao, Wei Hsian Yin
Journal: Journal of the American College of Cardiology (2025)
TCTAP C-236 Successful Catheter-Directed Thrombolysis for Massive Pulmonary Embolism in a Patient With Recent Cerebral Hemorrhage
Authors: Chi Cuong Tran, Duc Chinh Nguyen, Chi Quyen Mach, Xuan Bach Cao, Thi Thao Trang Nguyen, Duc Cam Tran, Duong Khanh Nguyen, Mai Hoang, Loc Vu, Thach Nguyen
Journal: Journal of the American College of Cardiology (2025)
TCTAP C-214 A Challenging Case Report of Abiotrophia Defectiva Infective Endocarditis Complicated by a Ruptured Pseudoaneurysm of the ATS Aortic Valve Replacement Extending to the Right Ventricle, Along With Ruptured Chordae of the Mitral and Tricuspid Valves
Authors: Teerana Uisrikoon, Surapan Pongsuthana, Wittawat Wattanasiriporn, Jaidwarong Thanakitcharu
Journal: Journal of the American College of Cardiology (2025)
TCTAP C-226 One-Stage Transcatheter Aortic Valve Implantation and Transcatheter Edge-to-Edge Tricuspid Valve Repair for Multiple Valvular Heart Disease in a High-Risk Patient
Authors: Senthilraj Thangasami, Lim Su Min, Wang Bin, Wang Yan, Xiang Chen, Antonio Felipe Leite Simao
Journal: Journal of the American College of Cardiology (2025)
TCTAP C-213 Role of Photon-Counting Computed Tomography in Detecting High-Risk Unstable Angina Patient: A Case Report
Authors: Duc Chinh Nguyen, Thi Quynh Huong Tran, Hoang Dil Mai, Duc Cam Tran, Duong Quoc Anh Nguyen, Chi Cuong Tran
Journal: Journal of the American College of Cardiology (2025)
TCTAP C-234 Coil Embolization With Distal Protection Using Balloon Occlusion Technique in a Left Renal Arteriovenous Fistula Presenting With Gross Hematuria and Shock: A Case Report
Authors: Harishankar Pratap Singh Chandel, Akhilesh Dubey, Shishir Soni
Journal: Journal of the American College of Cardiology (2025)
TCTAP C-239 From Blocked to Clear: Upfront Large-Bore Aspiration Thrombectomy for Intermediate-High Risk Pulmonary Embolism
Authors: Ji Ken Ow, Hafidz Abd Hadi, Ming Yoong Low, Afif Ashari, Ting Yuen Beh, Steven Wong Poh Hock
Journal: Journal of the American College of Cardiology (2025)
TCTAP C-051 Drug Coated Balloon (DCB) Enhanced Modified Jailed Balloon Technique in a Double Bifurcation Lesion in the Setting of ST-Elevation Myocardial Infarction - A Novel Technique for Simplifying Complex Bifurcation Lesions
Authors: Wee Meng Ng, Alimi Ahmad Hatib, Eran Sim, Fahim Jafary
Journal: Journal of the American College of Cardiology (2025)
TCTAP C-199 AI-Reconstructed Ultra-High-Resolution CCTA and Intravascular Lithotripsy-Assisted PCI for Severe Concentric and Eccentric Calcified Plaques
Authors: Hirofumi Ohashi, Koshiro Sakai, Masanobu Fujimoto, Akihiro Suzuki, Hirohiko Ando, Carlos Collet, Tetsuya Amano
Journal: Journal of the American College of Cardiology (2025)
TCTAP C-148 Unraveling the Loop: Successful Resolution of a Rare and Complex Intra-Aortic Balloon Pumping Complication Without Surgery
Authors: Hiroto Tanaka, Keiichiro Yamane, Soichiro Enomoto, Hirokazu Kondo, Toshihiro Tamura
Journal: Journal of the American College of Cardiology (2025)
Efficacy of interventions for the treatment of irritable bowel syndrome, functional abdominal pain—not otherwise specified, and abdominal migraine in children: a systematic review and network meta-analysis
Authors: Vasiliki Sinopoulou, Jip Groen, Morris Gordon, Ed Mougey, James P Franciosi, Tim G J de Meij, Merit M Tabbers, Marc A Benninga
Journal: The Lancet Child & Adolescent Health (2025)

Many treatments for abdominal pain-related disorders of gut-brain interaction (AP-DGBI) in children have been studied. We aimed to assess the efficacy and safety of all known treatment options for paediatric AP-DGBI. For this systematic review and network meta-analysis, we searched Embase, MEDLINE, and CENTRAL databases from inception to Jan 16, 2025, for published randomised controlled trials. We included trials of any treatment for AP-DGBIs (irritable bowel syndrome, functional abdominal pain-not otherwise specified, and abdominal migraine, excluding functional dyspepsia) in children aged 4-18 years. We excluded randomised controlled trials that solely included children with functional dyspepsia, but we included studies in which children with functional dyspepsia were included alongside children with the other AP-DGBI diagnoses and outcome data could not be separated. Data extraction and quality appraisal were performed in duplicate. The primary outcome for this network meta-analysis was author-defined treatment success. Network meta-analysis methodology was used within a frequentist framework using multivariate meta-analysis and outcomes were assessed using the Grading of Recommendations, Assessment, Development and Evaluation methodology. Clinical relevance of effect sizes was interpreted according to consensus definitions. Of 19 337 records identified through the database search, 155 records representing 91 original randomised controlled trials were included in the network meta-analysis: these 91 trials comprised 7226 participants (4119 females and 2673 males). 12 studies assessed dietary treatments (n=730), 25 assessed pharmacological treatments (n=2140), 23 assessed probiotic treatments (n=1762), and 35 assessed psychosocial treatments (n=2952). Two treatments were probably more effective for treatment success than control treatments (moderate certainty): hypnotherapy (risk ratio [RR] 4·99 [95% CI 2·15 to 11·57]; large effect size) and cognitive behavioural therapy (CBT; RR 1·99 [95% CI 1·33 to 2·98]; moderate effect size). All other treatments evaluated for treatment success were either not effective or the data were of very low certainty and thus no conclusions could be made. Hypnotherapy and CBT show moderate certainty for treatment efficacy with clinically relevant effect sizes. No conclusions can be made about the other therapies and treatment success due to very low evidence certainty. Future randomised controlled trials should focus on improving the evidence certainty for those other therapies with regard to core AP-DGBI outcomes. None.
Efficacy and safety of ziresovir in hospitalised infants aged 6 months or younger with respiratory syncytial virus infection in China: findings from a phase 3 randomised trial with 24-month follow-up
Authors: Han Zhang, Wei Zhao, Xiaoyan Zhang, Lei Zhang, Run Guo, Han Huang, Li Lin, Feng Liu, Haidan Chen, Fangfang Shen, Jinzhun Wu, Xiaowen Huang, Xiaoping Zhu, Feng Li, Gang Zou, Jason Chien, Michael Humphries, Quan Lu, Jim Z Wu, Shunying Zhao, Hanmin Liu, Xin Ni
Journal: The Lancet Child & Adolescent Health (2025)
Accelerating access to paediatric medicines: lessons learned from the Global Accelerator for Paediatric Formulations, a WHO-hosted network
Authors: Martina Penazzato, Asma Hafiz, Sébastien Morin, Farihah Malik, Bernadette Cappello, Jennifer Cohn, Tim R Cressey, Patricia Fassinou, Anthony J Garcia-Prats, Luann Hatane, Janice Soo Fern Lee, Tiziana Masini, Atieno Ojoo, Theodore Ruel, David Ruiz Villafranca, Marie Valentin, John C Reeder
Journal: The Lancet Child & Adolescent Health (2025)
Optogenetic induction of TDP-43 aggregation impairs neuronal integrity and behavior in Caenorhabditis elegans
Authors: Kyung Hwan Park, Euihyeon Yu, Sooji Choi, Sangyeong Kim, Chanbin Park, J Eugene Lee, Kyung Won Kim
Journal: Translational Neurodegeneration (2025)

Abstract Background Cytoplasmic aggregation of TAR DNA binding protein 43 (TDP-43) in neurons is one of the hallmarks of TDP-43 proteinopathy. Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are closely associated with TDP-43 proteinopathy; however, it remains uncertain whether TDP-43 aggregation initiates the pathology or is a consequence of it. Methods To demonstrate the pathology of TDP-43 aggregation, we applied the optoDroplet technique in Caenorhabditis elegans ( C. elegans ), which allows spatiotemporal modulation of TDP-43 phase separation and assembly. Results We demonstrate that optogenetically induced TDP-43 aggregates exhibited insolubility similar to that observed in TDP-43 proteinopathy. These aggregates increased the severity of neurodegeneration, particularly in GABAergic motor neurons, and exacerbated sensorimotor dysfunction in C. elegans . Conclusions We present an optogenetic C. elegans model of TDP-43 proteinopathy that provides insight into the neuropathological mechanisms of TDP-43 aggregates. Our model serves as a promising tool for identifying therapeutic targets for TDP-43 proteinopathy.
GCRP: Integrated Global Chicken Reference Panel from 11,951 Chicken Genomes
Authors: Di Zhu, Yuzhan Wang, Hao Qu, Chugang Feng, Hui Zhang, Zheya Sheng, Yunliang Jiang, Qinghua Nie, Suqiao Chu, Dingming Shu, Ziqin Jiang, Dexiang Zhang, Lingzhao Fang, Hui Li, Zhenqiang Xu, Yiqiang Zhao, Yuzhe Wang, Xiaoxiang Hu
Journal: Genomics Proteomics & Bioinformatics (2025)

Abstract Chickens are a crucial source of protein for humans and a popular model animal for bird research. Despite the emergence of imputation as a reliable genotyping strategy for large populations, the lack of a high-quality chicken reference panel has hindered progress in chicken genome research. To address this, here we introduce the first phase of the 100K Global Chicken Reference Panel (100K GCRP). Currently, two panels are available: a comprehensive mix panel (CMP) for domestication diversity research and a commercial breed panel (CBP) for breeding broilers specifically. Evaluation of genotype imputation quality showed that CMP had the highest imputation accuracy compared to imputation using existing chicken panels in Animal-SNPAtlas and Animal Genotype Imputation Database (AGIDB), whereas CBP performed stably in the imputation of commercial populations. Additionally, we found that genome-wide association studies using GCRP-imputed data, whether on simulated or real phenotypes, exhibited greater statistical power. In conclusion, our study indicates that the GCRP effectively fills the gap in high-quality reference panels for chickens, providing an effective imputation platform for future genetic and breeding research. The project includes 11,951 samples and provides services for various applications on its website at http://farmrefpanel.com/GCRP/#/.
Re: Johann S. de Bono, Meng He, Chen Shi, et al. Final Overall Survival and Molecular Data Associated with Clinical Outcomes in Patients Receiving Ipatasertib and Abiraterone in the Phase 3 IPATential150 Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2024.12.015
Authors: Felix Melchior, Andreas Pircher, Isabel Heidegger
Journal: European Urology (2025)
Author Correction: Viscoelastic synthetic antigen-presenting cells for augmenting the potency of cancer therapies
Authors: Zeyang Liu, Yan-Ruide Li, Youcheng Yang, Yu Zhu, Weihao Yuan, Tyler Hoffman, Yifan Wu, Enbo Zhu, Jana Zarubova, Jun Shen, Haochen Nan, Kun-Wei Yeh, Mohammad Mahdi Hasani-Sadrabadi, Yichen Zhu, Ying Fang, Xinyang Ge, Zhizhong Li, Jennifer Soto, Tzung Hsiai, Lili Yang, Song Li
Journal: Nature Biomedical Engineering (2025)
Clocking Recurrence: Circulating Tumor HPV DNA Kinetics in Anal Cancer
Authors: Aron Bercz, Daniel L. Faden, J. Joshua Smith, Paul B. Romesser
Journal: Clinical Cancer Research (2025)

Abstract Detection of circulating tumor human papillomavirus DNA (ctHPVDNA) three months after completing definitive chemoradiation for localized anal squamous cell carcinoma associates with disease recurrence and inferior recurrence-free survival. These findings provide valuable insights into the temporal significance of ctHPVDNA detection in anal cancer and its potential implications for early intervention.
Human immunity to fungal infections
Authors: Donald C. Vinh
Journal: The Journal of Experimental Medicine (2025)

Fungi increasingly threaten health globally. Mycoses range from life-threatening, often iatrogenic conditions, to enigmatic syndromes occurring without apparent immunosuppression. Despite some recent advances in antifungal drug development, complementary therapeutic strategies are essential for addressing these opportunistic pathogens. One promising avenue is leveraging host immunity to combat fungal infections; this necessitates deeper understanding of the molecular immunology of human fungal susceptibility to differentiate beneficial versus harmful immunopathological responses. Investigating human models of fungal diseases in natural settings, particularly through genetic immunodeficiencies and ethnographic-specific genetic vulnerabilities, reveals crucial immune pathways essential for fighting various yeasts and molds. This review highlights the diversity in intrinsic fungal susceptibility across individuals and populations, through genetic- and autoantibody-mediated processes, complementing previous principles learned from animal studies and iatrogenic contexts. Improved understanding of human immunity to fungal diseases will facilitate the development of host-directed immunotherapies and targeted public health interventions, paving the way for precision medicine in fungal disease management.
Beyond Trial and Error: A Mathematical Model Wrangles DLBCL Heterogeneity Toward Optimizing Combination Therapy
Authors: Jordan S. Goldstein, Nick A. Phillips, Ash A. Alizadeh
Journal: Blood Cancer Discovery (2025)

Summary: In this issue of Blood Cancer Discovery, Pomeroy and Palmer present a new mathematical model, incorporating both inter- and intra-patient heterogeneity, to accurately predict outcomes for first-line combination therapies in diffuse large B-cell lymphoma. Their quantitative framework opens a range of possibilities for optimizing trial design and lymphoma therapy with potential to expedite clinical development. See related article by Pomeroy and Palmer, p. XX
Primary disorders of polyubiquitination: Dual roles in autoinflammation and immunodeficiency
Authors: András N. Spaan, Bertrand Boisson, Seth L. Masters
Journal: The Journal of Experimental Medicine (2025)

The last decades have brought a rapid expansion of the number of primary disorders related to the polyubiquitination pathways in humans. Most of these disorders manifest with two seemingly contradictory clinical phenotypes: autoinflammation, immunodeficiency, or both. We provide an overview of the molecular pathogenesis of these disorders, and their role in inflammation and infection. By focusing on data from human genetic diseases, we explore the complexities of the polyubiquitination pathways and the corresponding clinical phenotypes of their deficiencies. We offer a road map for the discovery of new genetic etiologies. By considering the triggers that induce inflammation, we propose autoinflammation and immunodeficiency as continuous clinical phenotypes.
Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
Authors: Pingmei Huang, Fenfen Ji, Alvin Ho-Kwan Cheung, Kaili Fu, Qiming Zhou, Xiao Ding, Danyu Chen, Yufeng Lin, Luyao Wang, Ying Jiao, Eagle S.H. Chu, Wei Kang, Ka Fai To, Jun Yu, Chi Chun Wong
Journal: Cell Host & Microbe (2025)
Molecular landscape of distinct follicular lymphoma histologic grades: insights from genomic and transcriptome analyses
Authors: Cong Sun, Wei Li, Jingwei Yu, Tingting Zhang, Wenchen Gong, Hengqi Liu, Fenghua Gao, Zheng Song, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Bin Meng, Yanan Gao, Junzhi Li, Xia Liu, Weicheng Ren, Qiang Pan-Hammarström, Xianhuo Wang, Huilai Zhang
Journal: Leukemia (2025)
Fluoroalkane Engineered Magnetic Vectors Unlock the Potential of Gasdermin in Vivo Delivery for Pyroptosis Induced Cancer Therapy
Authors: Yiling Ruan, Yang Liu, Guojun Lei, Yuan Shao, Yaxuan Zhao, Jinglang Gong, Keying Li, Xiaojiang Xie, Shouju Wang, Xiaolian Sun
Journal: Advanced Healthcare Materials (2025)

Abstract Pyroptosis, a programmed necrotic cell death mediated by gasdermin, can activate strong immune responses and serve as a potential target for cancer therapy. Nevertheless, the relatively large molecular size and negative surface charge of gasdermin impede them from effectively intracellular delivery and directly inducing pyroptosis. Here, a cytosolic protein delivery system, fluorinated iron oxide nanoparticles (FIONPs) is reported, which can self‐assemble with active gasdermin A3 protein (GSDMA3) via noncovalent interactions and effectively trigger pyroptosis in 4T1 cells. It is proved that the delivery system is versatile for various cargo proteins (ribonuclease A, saporin, β‐galactosidase, and bovine serum albumin) with different isoelectric points and molecular weights, without compromising their biological activity in vitro. What's more, under magnetic drive, FIONPs facilitate active transport of GSDMA3 in vivo, further augmenting tumor suppression and immune response. Overall, magnetic‐driven FIONPs provide an effective delivery system for intracellular protein transductions, and the application of the delivery system reveals that direct delivery of GSDMA3 significantly elicits robust antitumor immunity via the induction of pyroptosis.
Outcomes of patients with relapsed/refractory lymphoplasmacytic lymphoma/waldenström macroglobulinemia treated with venetoclax: a multicenter retrospective analysis
Authors: Y Sawalha, S Sarosiek, R L Welkie, S Seif, S Thapa, S Zanwar, K Cahill, R Treitman, H Shah, S Arora, G Pongas, A Winter, A Major, P A Riedell, M L Palomba, P Kapoor, A Grajales-Cruz, K H Shain, S K Thomas, J J Castillo
Journal: Blood Cancer Journal (2025)

Venetoclax showed promising activity in a small phase II trial in relapsed/refractory Waldenström macroglobulinemia (WM). To report the clinical activity of venetoclax and prognostic factors associated with outcomes in a larger cohort, we retrospectively identified 76 patients with relapsed/refractory lymphoplasmacytic lymphoma (LPL)/WM treated with venetoclax monotherapy at nine US medical centers. The median age at venetoclax treatment initiation was 66 years. MYD88, CXCR4, and TP53 mutations were detected in 65 (94%), 23 (40%), and 10 (22%) patients, respectively. The median number of prior lines of treatment was 3, including covalent BTK inhibitor in 82% and alkylating agent in 71% of patients. The overall and major response rates to venetoclax were 70% and 63%, respectively. The median and 2-year progression-free survival (PFS) were 28.5 months and 57%, respectively. The median and 2-year overall survival were not reached and 82%, respectively. Prior treatment with BTK inhibitor was the only factor associated with PFS in multivariate analysis (hazard ratio 2.97, p = 0.012). Venetoclax dose interruptions and/or reductions occurred in 27 patients (41%). Five patients (7%) developed laboratory tumor lysis syndrome (TLS), including 3 (4%) with clinical TLS. Venetoclax resulted in a high response rate and a prolonged PFS in patients with heavily pretreated LPL/WM.
Clinical and plasma proteomic characterization of heart failure with supranormal left ventricular ejection fraction: An emerging entity of heart failure
Authors: Yasuhiko Sakata, Kotaro Nochioka, Satoshi Yasuda, Koichi Ishida, Takashi Shiroto, Jun Takahashi, Shintaro Kasahara, Ruri Abe, Shinsuke Yamanaka, Takahide Fujihashi, Hideka Hayashi, Shintaro Kato, Katsunori Horii, Kanako Teramoto, Tsutomu Tomita, Satoshi Miyata, Koichiro Sugimura, Iwao Waga, Masao Nagasaki, Hiroaki Shimokawa
Journal: European Journal of Heart Failure (2025)
Correction: Regulatory T cells promote the stemness of leukemia stem cells through IL10 cytokine-related signaling pathway
Authors: Yingxi Xu, Junli Mou, Ying Wang, Wei Zhou, Qing Rao, Haiyan Xing, Zheng Tian, Kejing Tang, Min Wang, Jianxiang Wang
Journal: Leukemia (2025)
Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor–Initiating Cells Characterized by IFN/STAT1 Activity
Authors: Eric P. Souto, Ping Gong, John D. Landua, Ramakrishnan Rajaram Srinivasan, Abhinaya Ganesan, Lacey E. Dobrolecki, Stephen C. Purdy, Xingxin Pan, Michael Zeosky, Anna Chung, S. Stephen Yi, Heide L. Ford, Michael T. Lewis
Journal: Cancer Research (2025)

Abstract A tumor cell subpopulation of tumor-initiating cells (TIC) or “cancer stem cells” is associated with therapeutic resistance, as well as both local and distant recurrences. Signal transducer and activator of transcription (STAT) activity is elevated in TICs in claudin-low models of human triple-negative breast cancer, which enables enrichment of TICs using a STAT-responsive reporter. Lineage tracing of TICs as they undergo cell state changes could enable a better understanding of the molecular phenotypes of TIC and uncover strategies to selectively target TICs. In this study, we developed a STAT-responsive lineage-tracing system and used it in conjunction with the original reporter to enrich for cells with enhanced mammosphere-forming potential. This approach was able to detect TICs in some, but not all, basal-like triple-negative breast cancer xenograft models, indicating that STAT signaling has both TIC-related and TIC-independent functions. Single-cell RNA sequencing (RNA-seq) of reporter-tagged xenografts and clinical samples identified a common IFN/STAT1-associated transcriptional state in TICs that was previously linked to inflammation and macrophage differentiation. Surprisingly, most of the identified genes were not present in previously published TIC signatures derived using bulk RNA-seq. Finally, bone marrow stromal cell antigen-2 was identified as a cell surface marker of this state that functionally regulated TIC frequency. These results suggest that TICs may exploit the IFN/STAT1 signaling axis to promote their activity and that targeting this pathway may help eliminate TICs. Significance: Coupling single-cell transcriptomics with tumor-initiating cell enrichment identified IFN response gene expression not previously reported in bulk RNA-sequencing–derived signatures and proposed IFN/STAT1 signaling as a candidate therapeutic target in breast cancer.