tbuckley/cabot-search huggingface dataset:
ORGANIC DISEASE OBSCURED BY NEUROTIC BEHAVIOR
Authors: Milton C. Borman
Journal: Annals of Internal Medicine (1937)

Article1 May 1937ORGANIC DISEASE OBSCURED BY NEUROTIC BEHAVIORMILTON C. BORMAN, M.S., M.D., F.A.C.P.MILTON C. BORMAN, M.S., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-11-1683 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe frequency of neurotic behavior in patients seen in general medical practice, the difficulties met in making accurate diagnoses and in caring for such patients, the present interest of physicians and surgeons in this subject as shown by their writings and discussions, and the increasing number of patients labelled "neurotic," emphasize the importance of critical evaluation of emotional states in the sick.Symptoms of neurotic origin simulating true organic disease, but without demonstrable lesion, are common. Neurotic behavior, however, may follow or be intensified by organic disease, or such behavior may exist in the presence of organic lesions, in an... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, Wisconsin*Received for publication February 4, 1937.From the Sacred Heart Sanitarium, Milwaukee, Wis. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1937Volume 10, Issue 11Page: 1683-1685KeywordsBehaviorEmotionsHeartLesionsSurgeons ePublished: 1 December 2008 Issue Published: 1 May 1937 PDF downloadLoading ...
Cardiospasm with Associated Arthritis
Authors: John H. Fitzgibbon
Journal: Annals of Internal Medicine (1933)

Article1 April 1933Cardiospasm with Associated ArthritisJOHN H. FITZGIBBON, M.D., F.A.C.P.JOHN H. FITZGIBBON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-10-1305 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany etiological and contributing factors have been mentioned in the literature of arthritis, but cases in which the condition is associated with esophageal obstruction must be relatively rare.For five years, I have had under observation and treatment a patient in whom cardiospasm and arthritis are intimately associated. As symptoms of arthritis have at times accompanied the appearance of difficulty in swallowing and have improved after dilatation of the stenosis, it seems worth while to report the case as one in which there appears to be an intimate etiological relationship between esophageal obstruction and arthritis.CASE REPORTMrs. L. S....Reference1 FITZGIBBON JH: Modifications of the Sippy cardiospasm dilator, Northwest Med., 1930, xxix, 4, 171. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon*Received for publication July 13, 1932. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1933Volume 6, Issue 10Page: 1305-1307KeywordsArthritisCardiospasmPatientsStenosisSwallowing ePublished: 1 December 2008 Issue Published: 1 April 1933 PDF downloadLoading ...
“We’d better do it under local”
Authors: Richard Ashford
Journal: BMJ (2008)

She had been discharged from our breast cancer clinic almost 10 years earlier. There was no reason for her to think she might have relapsed when the bowel investigations at another hospital were normal. Because she had complained about her “waterworks,” she was referred to their local urologists for cystoscopy, but, just in case, the gastroenterologist had also arranged for computed tomography. She was due her cystoscopy after her CT scan but before being reviewed by the gastroenterologist, and she was therefore seen …
Disease of the digestive system: Postgastrectomy problems--I
Authors: J. A. Williams
Journal: BMJ (1967)

Partial gastrectomy has an excellent record in the treatment of peptic ulcer; in the well-chosen case its successes far outweigh its disadvantages.Nevertheless between 5% and 15% of patients continue to complain of serious symptoms after operation.As the number of patients subjected to partial gastrectomy in England and Wales in 1961 was approximately 26,000, if 10% of these develop some form of " postgastrectomy syndrome" then this will not be a rare problem.The com- monest symptoms of patients who complain after gastrectomy are abdominal pain, vomiting, loss of weight, loss of energy, attacks of faintness, and diarrhoea.These symptoms usually do not occur singly but combine in an infinite variety of com- plexes that have become known as the "postgastrectomy syndromes."There is a good case for discarding the present concept of these as classical syndromes.Many syndromes have, been described, including those prefixed by the term dumping, afferent loop, and even efferent loop, long loop, and small stomach.To list these syndromes and describe their classical clinical pictures may help to place some of the known facts in an orderly fashion, but it is mis- leading in that it implies knowledge of the pathogenesis of the patient's symptoms.To categorize a patient as having the " afferent loop syndrome " implies that we know the cause of his symptoms and-often incorrectly--blame the afferent loop for their cause.Even the most closely studied and best under- stood postgastrectomy disease, the " dumping syndrome," has in its name an implied aetiology which explains only a small part of the syndrome.A further confusion is that the term dumping syndrome implies a different disease in different parts of the world.To some doctors the term is restricted to the feeling of faintness, nervousness, and flushing provoked by hypertonic foods, while others use it to encompass symptoms of vomiting, pain, and diarrhoea, or almost any symptom that occurs after gastric operations.Dumping may be a useful term to retain but only in the former limited sense.This article will therefore be restricted to an evaluation and investigation of the symptoms of which patients complain, and readers who require descriptions of the variously defined syn- dromes are referred to the bibliography.There are two groups of complications which usually present in different ways.Patients with abdominal complications such as pain, vomiting, or diarrhoea usually complain of these symp- toms and demand attention from their doctor, while many of those with loss of weight, lack of energy, and the less dramatic symptoms of nutritional deficiency do not readily report for medical attention.However, the frequency of the nutritional complications is sufficiently high to justify a planned, even though infrequent, follow-up programme.The nutritional complications will not be considered in detail in this article.
Are fluoxetine plasma levels related to outcome in obsessive-compulsive disorder?
Authors: Koran Lm, Cain Jw, Dominguez Ra, Rush Aj, Thiemann S
Journal: American Journal of Psychiatry (1996)

In obsessive-compulsive disorder, the relationship between blood levels of serotonin reuptake inhibitors and clinical outcome is unclear. In a multicenter trial, the authors examined the relationship between steady state plasma levels of fluoxetine and norfluoxetine (determined after 7 weeks of treatment), and their sum, and clinical outcome.Ratings of symptom severity of obsessive-compulsive disorder (Yale-Brown Obsessive Compulsive Scale scores) were obtained at baseline and after 13 weeks for 200 adult outpatients with moderately severe obsessive-compulsive disorder treated with fluoxetine doses of 20 mg/day (N = 68), 40 mg/day (N = 64), and 60 mg/day (N = 68).Mean plasma levels of fluoxetine and norfluoxetine were statistically significantly higher with higher dose. Statistical analyses revealed no significant relationship for plasma level of either molecule or their sum in predicting endpoint percent change in obsessive-compulsive scores. Plasma levels of patients with a marked response (decrease of 50% or more in obsessive-compulsive score) did not differ significantly from those of nonresponders (less than a 25% decrease in obsessive-compulsive score). No hint was seen of a therapeutic window or of a relationship limited to one gender or within the lowest dose group (20 mg/day). However, since S-norfluoxetine is a much more potent serotonin reuptake inhibitor than R-norfluoxetine, the absence of chiral (stereospecific) assays in this study limits the results.Steady state plasma levels of fluoxetine and norfluoxetine are not related to clinical outcome in patients with obsessive-compulsive disorder. Individual patients can be told only that the optimum dose of fluoxetine for them will be the dose that produces the largest therapeutic effect with the smallest side effect burden. Future studies should examine the predictive utility of measures of serotonergic neuronal function and, if plasma levels of norfluoxetine are examined, the use of chiral assays.
Effect of cigarette smoking on muscle in vitamin D deficient mice
Authors: Nele Cielen, Nele Heulens, Karen Maes, Ghislaine Gayan-Ramirez, Wim Janssens, Marc Decramer
Journal: European Respiratory Journal (2014)

Rationale: Skeletal muscle weakness is a major complication in COPD patients. Vitamin D (vitD), which is essential for maintaining skeletal muscle strength and performance, is low in COPD. We examined whether vitD deficiency would enhance muscle susceptibility to smoking has been examined in a smoking mouse model.  Methods: VitD deficient (normal calcium and phosphorus levels) and sufficient mice were daily exposed to room air or cigarette smoke (CS) for 6, 12 and 18 weeks. Afterwards, muscle function was measured  in vitro .  Results: VitD serum levels were 66% lower in VitD deficient mice. Smoking lowered body weight gain at each time point (no effect of vitD deficiency). In deficient mice, soleus mass was lower after smoking at each time point. Deficiency caused decreased muscle force of the EDL after 18 weeks (no extra effect of smoking) while soleus force was unchanged at each time point. Deficiency was found to enhance fatigability of the EDL at each time point. Smoking solely enhanced muscle fatigue in smoking mice with sufficient serum levels after 18 weeks. Muscle fiber proportions were unchanged in soleus and EDL at 12 weeks.  Conclusions: VitD deficiency decreased EDL force and enhanced fatigability over time, without an additional effect of smoking.
Abstract 18715: Left Atrial Pressure and Dominant Frequency of Atrial Fibrillation in Humans
Authors: Kentaro Yoshida, Magnus Ulfarsson, Hakan Oral, Thomas Crawford, Eric Good, Krit Jongnarangsin, Frank Bogun, Frank Pelosi, Jose Jalife, Fred Morady, Aman Chugh
Journal: Circulation (2010)

Background: Atrial stretch is thought to play a role in the development of atrial fibrillation (AF). However, the precise mechanism by which stretch contributes to AF maintenance in humans is unknown. Methods: The subjects of this study were 58 consecutive patients with persistent AF (n=40) or paroxysmal AF (n=18) undergoing left atrial (LA) ablation. LA pressure was measured before ablation. Both atria and the coronary sinus were mapped, and regional dominant frequency (DF) was determined by fast Fourier transformation. Results: The mean LA pressure in the persistent AF group was significantly higher than in the paroxysmal AF group (18±5 vs. 10±4 mm Hg, p<0.0001). The mean DF in the persistent AF group was also higher than in the paroxysmal AF group (6.36±0.51 and 5.83±0.54 Hz, p=0.0006). In patients with persistent AF, there was a significant correlation between LA pressure and the DF at 7 regions, including the LA appendage (r=0.55, p=0.0002). The mean DF was directly related to the duration of continu...
Abstract 14814: Timing of Very Late Stent Thrombosis Occurrence After Drug-eluting Stent and Bare-metal Stent Implantations
Authors: Shunsuke Kubo, Kazushige Kadota, Seiji Habara, Hiroyuki Tanaka, Yasushi Fuku, Harumi Katoh, Naoki Oka, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Circulation (2011)

Background: Recently, very late stent thrombosis (VLST) after drug-eluting stent (DES) implantation has been reported. However, there is no data available to compare the characteristics of VLST aft...
SURGICAL PROCEDURES IN ESSENTIAL HYPERTENSION
Authors: George E. Brown
Journal: Annals of Internal Medicine (1935)

Editorial1 October 1935SURGICAL PROCEDURES IN ESSENTIAL HYPERTENSIONGEORGE E. BROWNGEORGE E. BROWNSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-4-488 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe early work of Claude Bernard on the discovery of the vasomotor nerves was an event of tremendous importance. The application of this knowledge to problems in clinical medicine was delayed for half a century. The past decade has demonstrated in a most convincing fashion that, in man, removal of the sympathetic ganglions is followed by permanent vasodilatation of the arteries of the extremities. This has also been demonstrated in the experimental animal by exact quantitative methods. The thermostromuhr method of Rein, thermometric readings in the deep and superficial tissues, have furnished controlled experimental evidence of this fact. Equally convincing... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Submitted for publication September 11, 1935. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1935Volume 9, Issue 4Page: 488-489KeywordsArteriesHypertensionNervesVasodilation ePublished: 1 December 2008 Issue Published: 1 October 1935 PDF downloadLoading ...
A GRAPHIC STUDY OF THE CHANGES IN THE MUSCULAR ACTIVITY OF THE STOMACH ASSOCIATED WITH CERTAIN EPIGASTRIC SYMPTOMS
Authors: P. B. Welch
Journal: Annals of Internal Medicine (1933)

Article1 August 1933A GRAPHIC STUDY OF THE CHANGES IN THE MUSCULAR ACTIVITY OF THE STOMACH ASSOCIATED WITH CERTAIN EPIGASTRIC SYMPTOMSP. B. WELCH, M.D., F.A.C.P.P. B. WELCH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-2-251 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSome years ago (1924) while the effect of feeding upon the muscular activity of the colon was being studied,1 it seemed that a similar investigation of the muscular activity of the stomach might satisfactorily explain the almost constantly presented symptom of epigastric distress, the distress usually described by the patient as "gas." A perhaps cursory survey of the literature failed to supply any satisfactory physiopathologic explanation of the association of this symptom complex with so many different kinds and gradations of abdominal pathologic lesions or disturbed functions.It seemed opportune to make a beginning at least by recording exactly what...References1. WELCHPLANT PBOH: A graphic study of the muscular activity of the colon, with special reference to its response to feeding, Am. Jr. Med. Sci., 1926, clxxii, 261-268. CrossrefGoogle Scholar2. BRODIE TG: On recording variations in volume by air-transmission. A new form of volume-recorder, Jr. Physiol., xxvii, 473-487. Google Scholar3. CARLSON AJ: Control of hunger in health and disease, 1916, University of Chicago Press, Chicago, p. 28. Google Scholar4. CARLSON AJ: Control of hunger in health and disease, 1916, University of Chicago Press, Chicago, pp. 164-165. Google Scholar5. CARLSONLITT AJS: Studies on the visceral nervous system: on the reflex control of the pylorus, Arch. Int. Med., 1924, xxxiii, 281-291. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Coral Gables, Florida*Received for publication December 27, 1932. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe mechanism of production of digestive symptoms associated with urologic pathology 1 August 1933Volume 7, Issue 2Page: 251-256KeywordsColonLesionsStomach ePublished: 1 December 2008 Issue Published: 1 August 1933 PDF downloadLoading ...
Abstract 15441: Differential Sequestration of mRNA in Ribonucleoprotein Granules in the Heart
Authors: Jessica Toli, Minzhen He, Zhi Yang, Mona Abouhabib, Maha Abdellatif
Journal: Circulation (2011)

Posttranscriptional regulation of gene expression is fundamental to organogenesis and pathogenesis. One of the modes of regulation that has been observed, particularly during stress conditions, is the formation of stress granules. These granules have been shown to sequester mRNA in a microscopically visible complex with RNA-binding proteins that mainly include cytotoxic granule-associated RNA binding protein 1 (TIA-1 and TIAR). The proposed functions of these granules range from RNA storage to mRNA decay, depending on the cell and its environment. Until now we don’t know if these granules exist in the myocardium under any condition. Accordingly, we hypothesized that RNA granules assemble in the heart in association with selective mRNAs as a mechanism to differentially regulate protein translation during myocyte growth or stress conditions. To address this, we applied immunocytochemistry and immunoprecipitation (IP)-qPCR approaches in cardiac myocytes exposed to growth, hypoxia, and hypoglycemic conditions...
Abstract 12144: Impact of Different Catheter Ablation Strategies on Procedure Outcome in Coexistent Atrial Flutter and Fibrillation: Results From a Single-Blinded Randomized Study (APPROVAL)
Authors: Sanghamitra Mohanty, Prasant Mohanty, Luigi Di Biase, Rong Bai, Agnes Pump, Pasquale Santangeli, Michela Casella, Antonio Dello Russo, Claudio Tondo, Sakis Themistoklakis, Antonio Raviele, Antonio Rossillo, Andrea Corrado, Gemma Pelargonio, Giovanni Forleo, David Burkhardt, Javier Sanchez, Joseph Gallinghouse, Rhodney Horton, Shane Bailey, Jason Zagrodzky, Andrea Natale
Journal: Circulation (2011)

Introduction: This study aimed to compare the impact of different ablation strategies on AF recurrence and quality of life (QoL) in coexistent atrial fibrillation (AF) and flutter (AFL). Method: Ei...
O096 : Matrix metalloproteinase-10 contributes to hepatocellular carcinoma development in a novel crosstalk with stromal derived growth factor 1/C-X-C chemokine receptor 4 axis
Authors: O. Garcia-Irigoyen, M.U. Latasa, S. Carotti, I. Uriarte, M. Elizalde, R. Urtasun, U. Vespasiani-Gentilucci, S. Morini, J.M. Ladero, P. Benito, J.A. Rodriguez, J. Orbe, J. Prieto, J.A. Paramo, M.G. Fernandez-Barrena, C. Berasain, M.A. Avila
Journal: Journal of Hepatology (2015)
CHANCRES STUDIED FROM THE PUBLIC HEALTH POINT OF VIEW
Authors: Charles Walter Clarke
Journal: Annals of Internal Medicine (1939)

Article1 December 1939CHANCRES STUDIED FROM THE PUBLIC HEALTH POINT OF VIEWCHARLES WALTER CLARKE, M.A., M.D., F.A.C.P.CHARLES WALTER CLARKE, M.A., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-6-928 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOut of the large collection of case records in the syphilis clinics of the New York City Department of Health a sample of 15,090 records was taken at random from the active files, and studied to ascertain certain facts regarding the primary or chancre stage of syphilis in our clinic case load. Among the 15,090 case records were 971, or 6.43 per cent, indicating a definite diagnosis of chancre by the darkfield method at the time of admission to the clinic service. There were in addition, 7,386 records giving a definite history of chancres, 48.95 per cent of the total....References1. HAZEN HM (a) : Syphilis, 1928, C. V. Mosby Co., St. Louis, pages 35 and 78. (b) ORMSBY, O. S.: Diseases of the skin, 1937, Lea and Febiger, Philadelphia, page 813. (c) WAGENER, F.: Extragenitale syphilitische Primaraffekts an der Bonner Hautklinik seit 1924, Inaug. Dissert., Bonn, 1935. (d) SZEWACHOWSKI, P.: The localization of the syphilitic chancre, Ann. d. mal. ven., Paris, 1935, xxx, 43. Google Scholar2. DAVIES TA: Primary syphilis in the female, 1931, Oxford Publication, page 10. (Out of 584 primary chancres in women Dr. Davies found 256 or 44.0 per cent on the cervix.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication February 27, 1939.†With assistance from John L. Gillen, M.D., Clinical Assistant and Marie Di Mario, Statistician, New York City Department of Health. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGenitale und extragenitale PrimäraffekteThe Oral Manifestations of Syphilis 1 December 1939Volume 13, Issue 6Page: 928-939KeywordsElectronic medical recordsHealth statisticsPrevention, policy, and public healthSyphilis ePublished: 1 December 2008 Issue Published: 1 December 1939 PDF downloadLoading ...
Newer Methods in Tuberculosis Therapy
Authors: Benjamin Goldberg
Journal: Annals of Internal Medicine (1930)

Article1 March 1930Newer Methods in Tuberculosis TherapyBENJAMIN GOLDBERG, M.D.BENJAMIN GOLDBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-9-910 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt the International Congress on Tuberculosis in Washington in 1908, in greeting the delegates, Dr. Edward Livingston Trudeau, said: "For thirty-five years I have lived in the midst of a perpetual epidemic, struggling with tuberculosis, both within and without the walls, and no one can appreciate better than I do the great meaning of such a meeting. I have lived through many of the long and dark years of ignorance, hopelessness, and apathy, when tuberculosis levied its pitiless toll on human life unheeded and unhindered; when, as Jaccoud has tersely put it, 'The treatment of tuberculosis was but a meditation... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*From the City of Chicago Municipal Tuberculosis Sanitarium and the University of Illinois College of Medicine.†Read at the Annual Mississippi Valley Conference on Tuberculosis, Grand Rapids, Michigan, on September 20, 1929. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1930Volume 3, Issue 9Page: 910-916 ePublished: 1 December 2008 Issue Published: 1 March 1930 PDF downloadLoading ...
18F-FDG PET/CT Findings of Scrub Typhus
Authors: Jahae Kim, Seong Young Kwon, Sae-Ryung Kang, Sang-Geon Cho, Ho-Chun Song
Journal: Clinical Nuclear Medicine (2015)

Scrub typhus is an acute infectious disease caused by Orienta tsutsugamushi, which is clinically manifested by fever, generalized lymphadenopathy, diffuse myalgia, headache, maculopapular rash, and eschars at the site of chigger feedings. Diagnosis of scrub typhus requires compatible clinical features, history of exposure, and result of selorogic testing. In recent years, F-FDG PET/CT is seen as having increasing potential for use in examination and management of patients with infectious or inflammatory disorders. This is a PET/CT case demonstrating scrub typhus in a patient without evidence of recurrence of thyroid papillary cancer.
Impact of CARDIOrespiratory FITness on Arrhythmia Recurrence in Obese Individuals With Atrial Fibrillation
Authors: Rajeev K. Pathak, Adrian Elliott, Melissa E. Middeldorp, Megan Meredith, Abhinav B. Mehta, Rajiv Mahajan, Jeroen M.L. Hendriks, Darragh Twomey, Jonathan M. Kalman, Walter P. Abhayaratna, Dennis H. Lau, Prashanthan Sanders
Journal: Journal of the American College of Cardiology (2015)