KETONIC AND NON-KETONIC ESTROGENS
Authors: W. W. Westerfeld, Edward A. Doisy
Journal: Annals of Internal Medicine (1937)

Article1 August 1937KETONIC AND NON-KETONIC ESTROGENSW. W. WESTERFELD, EDWARD A. DOISYW. W. WESTERFELDSearch for more papers by this author, EDWARD A. DOISYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-2-267 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONActive experimental work on the internal secretion of the ovary began with the demonstration of Knauer1 in 1899 that transplantation of the ovary from its normal site did not produce atrophy of the uterus. Following these experiments many other investigators have made important contributions to our knowledge in this field. Adler,2 Fellner,3 Hermann,4 Frank5 and others prepared extracts which were active in producing growth of the uterus.Two other investigations played an important rôle in the development of this field. The first was the introduction (Allen and Doisy6) of the accurate and convenient method of assay by the vaginal...References1. KNAUER E: Die Ovarien Transplantation, Arch. f. Gynäk., 1900, lx, 322. CrossrefGoogle Scholar2. ADLER L: Zur Physiologie und Pathologie der Ovarialfunktion, Arch. f. Gynäk., 1912, xcv, 349. Google Scholar3. FELLNER OO: Experimentelle erzeugte Wachstumsveränderungen am weiblichen Genitale der Kaninchen, Centralbl. f. allg. Path. u. path. Anat., 1912, xxiii, 673. Experimentelle Untersuchungen über die Wirkung von Gewebsextrakten aus der Plazenta und den weiblichen Sexualorganen auf das Genitale, Arch. f. Gynäk., 1913, c, 641. Google Scholar4. HERMANN E: Über eine wirksame Substanz im Eierstocke und in der Plazenta, Monatschr. f. Geburtsch. u. Gynäk., 1915, xli, 1. Google Scholar5. FRANK RT: The ovary and the endocrinologist, Jr. Am. Med. Assoc., 1922, lxxviii, 181. Google Scholar6. ALLENDOISY EEA: An ovarian hormone: preliminary report on its localization, extraction and partial purification and action in test animals, Jr. Am. Med. Assoc., 1923, lxxxi, 819. CrossrefGoogle Scholar7. ASCHEIMZONDEK SB: Hypophysenvorderlappen Hormon und Ovarialhormon im Harn von Schwangeren, Klin. Wchnschr., 1927, vi, 1322. CrossrefGoogle Scholar8. GIRARDSANDULESCOFRIDENSONRUTGERS AGAJJ: Sur une nouvelle hormone sexuelle cristallisée retirée de l'urine des juments gravides, Compt. rend. Acad. Sci., 1932, cxciv, 909. GIRARD, A., SANDULESCO, G., FRIDENSON, A., GAUDEFROY, C., and RUTGERS, J. J.: Sur les hormones sexuelles cristallisées retirées de l'urine des juments gravides, Compt. rend. Acad. Sci., 1932, cxciv, 1020. GIRARD, A., SANDULESCO, G., FRIDENSON, A., and RUTGERS, J. J.: Sur une nouvelle hormone sexuelle cristallisée, Compt. rend. Acad. Sci., 1932, cxcv, 981. SANDULESCO, G., WANG WEN TCHUNG, and GIRARD, A.: Contribution à la connaissance des hormones sexuelles femelles, Compt. rend. Acad. Sci., 1933, cxcvi, 137. Google Scholar9. WINTERSTEINERSCHWENKWHITMAN OEB: Estrogenic dihydroxy compounds in the urine of pregnant mares, Proc. Soc. Exper. Biol. and Med., 1935, xxxii, 1087. WINTERSTEINER, O., SCHWENK, E., HIRSCHMANN, H., and WHITMAN, B.: Chemical nature of δ-follicular hormone, Jr. Am. Chem. Soc., 1936, lviii, 2652. CrossrefGoogle Scholar10. COLLIPBROWNETHOMSON JBJSDL: The relation of emmenin to other estrogenic hormones, Jr. Biol. Chem., 1932, xcvii, xvii. The chemical nature of emmenin, Endocrinology, 1934, xviii, 71. Google Scholar11. MACCORQUODALETHAYERDOISY DWSAEA: The isolation of the principal estrogenic substance of liquor folliculi, Jr. Biol. Chem., 1936, cxv, 435. CrossrefGoogle Scholar12. GIRARDSANDULESCO AG: Sur une nouvelle série de réactifs du groupe carbonyle, leur utilisation á l'extraction des substances cétoniques et á la caracterisation microchimique des aldehydes et cétones, Helv. Chim. Acta, 1936, xix, 1095. CrossrefGoogle Scholar13. ZONDEK B: The fate of follicular hormone in the living body, Lancet, 1934, ii, 356. Über das Schicksal des Follikelhormons (Follikulin) im Organismus, Skandinav. Arch. f. Physiol., 1934, lxx, 133. CrossrefGoogle Scholar14. MAZERISRAEL CSL: The optimal dosage of estrogens, Jr. Am. Med. Assoc., 1937, cviii, 163. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis, Missouri*Read at the St. Louis meeting of the American College of Physicians, April 19, 1937.From the Biochemistry Department, St. Louis University School of Medicine, St. Louis. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChemical Determination of Estrogens in Human UrineContributo Allo Studio Della Disormonosi Delle Portatrici Di Ca. Dell'Utero: L'eliminazione Urinaria Del Pregnandiolo Dopo Carichi Con Progesterone Pre E Post Trattamento Chirurgico Ed Attinico.« Osservazioni Sul Comportamento Ormonale Sessuale Di Alcune Carcinomatose Uterine Prima E Dopo Trattamento Chirurgico Ed Attinico »Vitamine und HormoneThe Metabolism of the Estrogens Part OneThe Chemistry and Metabolism of the EstrogensTHE FECAL EXCRETION OF ESTROGENS BY PREGNANT COWSA QUANTITATIVE STUDY OF THE ADSORPTION OF ESTRONE, ESTRIOL, AND α-ESTRADIOL ON A CHROMATOGRAPHIC COLUMNDas Schicksal der Hormone im OrganismusThe Intermediate Metabolism of the Sex HormonesTHE EXCRETION OF ESTROGENS IN THE BILE AND URINE AFTER THE ADMINISTRATION OF ESTRONESTEROIDSMETABOLISM OF THE STEROID HORMONESTHE ISOLATION OF α-DIHYDROTHEELIN FROM HUMAN PREGNANCY URINEAnthelmintic Activity of Crystalline PapainConversion of Estradiol to Estrone in VivoTreatment of the menopause with estradiol dipropionateÜber ein 16‐Oxy‐testosteronPhytochemische Hydrierung von Oestron zu ?-OestradiolObservations concerning the metabolism of estrogens in womenTHE KETONIC ESTROGEN OF SOW OVARIESThe Significance of the Excretion of Sex Hormones in the UrineNeuere Ergebnisse auf dem Gebiet oestrogener Wirkstoffe (Follikelhormone)Neuere Ergebnisse auf dem Gebiet oestrogener Wirkstoffe (Follikelhormone) 1 August 1937Volume 11, Issue 2Page: 267-273KeywordsAtrophyBiochemistryEstrogensOvariesTransplantationUterus ePublished: 1 December 2008 Issue Published: 1 August 1937 Copyright & PermissionsCopyright, 1937, by The American College of PhysiciansPDF downloadLoading ...