tbuckley/cabot-search huggingface dataset:
Letter to the Editor: HKDC1 promotes liver cancer stemness under hypoxia via stabilizing β-catenin
Authors: Zhiya Zhang, Zhou Sun, Yin Liao
Journal: Hepatology (2024)

1Department of Oncology, The Second People's Hospital of Meishan City, Meishan, Sichuan, China 2The Third Clinical Hospital, Jilin University Correspondence Yin Liao, Department of Oncology, The Second People's Hospital of Meishan City, Meishan 620000, Sichuan, China. Email: [email protected] Correspondence Zhou Sun, The Third Clinical Hospital, Jilin University. Email: [email protected]
CD30 influences germinal center B-cell dynamics and the expansion of IgG1-switched B cells
Authors: Yan Wang, Ursula Rambold, Petra Fiedler, Tea Babushku, Claas L. Tapken, Kai P. Hoefig, Thomas P. Hofer, Heiko Adler, Ali Önder Yildirim, Lothar J. Strobl, Ursula Zimber-Strobl
Journal: Cellular and Molecular Immunology (2024)

Initially, identified as a Hodgkin lymphoma marker, CD30 was subsequently detected on a subset of human B cells within and around germinal centers (GCs). While CD30 expression is typically restricted to a few B cells, expansion of CD30-expressing B cells occurs in certain immune disorders and during viral infections. The role of CD30 in B cells remains largely unclear. To address this gap in knowledge, we established a conditional CD30-knockin mouse strain. In these mice, B-cell-specific CD30 expression led to a normal B-cell phenotype in young mice, but most aged mice exhibited significant expansion of B cells, T cells and myeloid cells and increased percentages of GC B cells and IgG1-switched cells. This may be driven by the expansion of CD4
Bariatric surgery meets TREM2+ macrophages to alleviate MASH independent of weight loss
Authors: Ziyi Meng, Jiandie D. Lin
Journal: Hepatology (2024)

Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan Medical Center, Ann Arbor, MI 48109 Correspondence Jiandie Lin, 5437 Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109. Email: [email protected]
Updates on pancreatic cancer treatment – invited special issue
Authors: Kevin Conlon, Roberto Coppola
Journal: International Journal of Surgery (2024)

Despite an increased understanding of the underlying biology of the disease, pancreatic ductal adenocarcinoma (PDAC) remains a challenging condition with poor outcomes and a 5-year survival rate, even at an early stage, of less than 10%. This dismal prognosis is due in part to biological aggressiveness, the lack of early diagnosis, suboptimal surgical selection, and the need for effective neoadjuvant and adjuvant therapies. However, progress is being made with significant advancements in the diagnosis, staging, and treatment of PDAC, with a focus on precision therapy, improved surgical care, and supportive care, coupled with a deeper understanding of PDAC's biology. This Special Issue aims to provide an overview of these advancements, summarizing recent research key findings and contributions.
Interfacility Transfer of Children With Time-Sensitive Surgical Conditions, 2002-2017
Authors: Kyle J. Van Arendonk, Elisabeth T. Tracy, Jonathan S. Ellison, Katherine T. Flynn-O’Brien, Samir K. Gadepalli, Adam B. Goldin, Matt Hall, Harold J. Leraas, Robert L. Ricca, Peter F. Ehrlich
Journal: JAMA Network Open (2024)

Surgical care for children in the United States has become increasingly regionalized among fewer centers over time. The degree to which regionalization may be associated with access to urgent surgical care for time-sensitive conditions is not clear.
Handheld Cellphone Use and Risky Driving in Adolescents
Authors: Catherine C. McDonald, Kevin Rix, Jeffrey P. Ebert, Subhash Aryal, Ruiying Xiong, Douglas J. Wiebe, M. Kit Delgado
Journal: JAMA Network Open (2024)

Importance Handheld cellphone use while driving is associated with increased motor vehicle crash risk among adolescents. Objective To examine the association of handheld cellphone use while driving with kinematic risky driving (KRD) events—hard braking and rapid acceleration—in adolescent drivers. Design, Setting, Participants Adolescents aged 16.50 to 17.99 years licensed 365 days or less in Pennsylvania were eligible to participate in this cross-sectional study. Enrollment occurred from July 29, 2021, to June 6, 2022. Participants downloaded a smartphone telematics cellphone app to record driving data for 60 days. Exposures Trip characteristics, including frequency, length, and duration; presence of speeding; frequency and duration of handheld cellphone use; time of day; and presence of precipitation. Main Outcomes and Measures Kinematic risky driving events per 100 miles driven. Zero-inflated Poisson regression models examined whether individual characteristics and trip characteristics were associated with KRD. Incidence rate ratios were computed. Results Of 405 adolescents who responded to recruitment, 151 enrolled, 140 completed study procedures, and 119 with 12 360 trips were included in the analytic sample (60 female participants [50.4%]; mean [SD] age, 17.2 [0.4] years). Adolescents drove a mean (SD) of 103.8 (65.7) trips, 565.0 (487.3) miles, and 25.1 (19.3) hours. Adolescents had minimal night trips (1.5% [192]), and few trips with precipitation present (9.0% [1097]). Speeding occurred in 43.9% (5428) of the trips and handheld cellphone use occurred in 34.1% (4214) of the trips. Kinematic risky driving events occurred in 10.9% (1358) of the trips at a rate of 2.65 per 100 miles. In adjusted models, increased KRD events were associated with handheld cellphone use (incidence rate ratio [IRR], 2.62; 95% CI, 1.53-4.48), speeding (IRR, 2.12; 95% CI, 1.06-4.26), and minutes driving (IRR, 1.02; 95% CI, 1.01-1.02). Trips at night, precipitation presence, licensure for less than 6 months, and sex were not associated with increased KRD events. Conclusions In this cross-sectional study of adolescent drivers, trips with handheld cellphone use and speeding were associated with higher rates of KRD, while individual characteristics were not. The findings suggest that smartphone telematics apps provide an opportunity to observe behaviors as well as surveil changes due to intervention efforts.
Vertical Integration and Care Experiences Among Medicare Advantage Beneficiaries
Authors: Geronimo Bejarano, Andrew Ryan, Amal Trivedi, David J. Meyers
Journal: JAMA Network Open (2024)

Importance Medicare Advantage (MA) beneficiaries are increasingly enrolling in integrated MA plans. Legacy-integrated plans share unique features that may differ from newer integrated MA plans. It is unclear whether integrated and legacy-integrated MA plans are associated with a better beneficiary care experience compared with non–legacy-integrated and nonintegrated MA plans. Objective To assess whether enrollment in integrated, legacy-integrated, non–legacy-integrated, and nonintegrated MA plans is associated with better beneficiary care experiences. Design, Setting, and Participants This cross-sectional study included MA beneficiaries who responded to Consumer Assessment of Healthcare Providers and Systems (CAHPS) surveys conducted annually between 2015 and 2019. Data analysis was performed between October 1, 2023, and July 31, 2024. Exposure Medicare Advantage plan integration status, categorized as integrated, legacy-integrated, non–legacy-integrated, and nonintegrated. Main Outcomes and Measures The CAHPS surveys assessed 9 care experience measures. To assess differences in care experience measures, mixed linear regression analyses were performed, adjusting for demographic characteristics, plan random effects, and state fixed effects. Results The sample consisted of 857 695 respondents. Their mean (SD) age was 72.6 (10.3) years, and 58.1% were women. A total of 12.7% of respondents were Black, 10.7% were Hispanic, and 71.0% were White. Compared with respondents in nonintegrated MA plans, respondents in integrated MA plans were younger (mean [SD] age, 72.7 [10.3] vs 72.2 [10.3] years, respectively) and were less likely to be Black (13.1% vs 11.2%, respectively), female (58.4% vs 57.2%, respectively), and partially dual eligible (8.7% vs 6.2%, respectively). Integrated MA plans were associated with meaningfully better mean ratings only of customer service (1.6 points [95% CI, 1.1-2.1]) and health plan (1.0 points [95% CI, 0.6-1.5]) compared with nonintegrated MA plans. Legacy-integrated MA plans were associated with meaningfully better mean ratings of drug plan (3.7 points [95% CI, 2.4-5.0]), health plan (3.1 points [95% CI, 1.7-4.5]), customer service (2.8 points [95% CI, 1.3-4.4]), getting appointments and care quickly (2.6 points [95% CI, 1.2-4.0]), health care quality (1.9 points [95% CI, 1.0-2.7]), physicians who communicate well (1.1 points [95% CI, 0.4-1.8]), and care coordination (1.1 points [95% CI, 0.4-1.9]) compared with nonintegrated MA plans. Conclusions and Relevance In this study, integrated MA plans were not associated with better beneficiary care experiences compared with nonintegrated MA plans. Legacy-integrated MA plans were associated with higher ratings on all care experience measures compared with both non–legacy-integrated and nonintegrated MA plans. Monitoring of integrated MA plans is needed to assess whether they are adding meaningful value to MA beneficiaries and to determine their effects on the health care system.
Asian American Diversity and Representation in the Health Care Workforce, 2007 to 2022
Authors: Michelle Ko, Kevin Dinh, Sarah Iv, Monica Hahn
Journal: JAMA Network Open (2024)

Importance Asian American individuals comprise over 40 ethnoracial groups but are regularly aggregated into 1 category within health workforce analysis, thus obscuring substantial inequities in representation. Objectives To describe trends in Asian American diversity across the 4 most populous US health professions (physicians, registered nurses, nursing assistants, and home health aides) and to characterize subgroup representation within professions. Design, Setting, and Participants Serial cross-sectional study from American Community Survey (ACS) population estimates of people reporting health profession occupations from 2007 to 2022. The ACS samples US residents every day, with approximately 3.5 million surveyed each year. Based on their sampling methods, the ACS then produces estimates of the entire US population for 1-year, 3-year, and 5-year periods. Data were analyzed from April to August 2024. Main Outcomes and Measures For each year and subgroup, the proportions of the US population, the profession, and Asian American individuals within the profession were calculated. The representation quotient (RQ) of each subgroup was then calculated, defined as the proportion of the subgroup within the profession of interest divided by the proportion of the subgroup within the US population. Trends were examined over the 15-year period. Results Over the 15-year period, Indian Americans composed the largest percentage of Asian American physicians (mean [SD], 40.6% [1.6%]), followed by Chinese Americans (mean [SD], 18.9% [1.4%]). Pakistani and Indian Americans had the highest relative representation (mean [SD] RQ, 8.9 [0.9] and 7.8 [0.9], respectively). Conversely, Cambodian and Hmong Americans remained largely underrepresented (mean [SD] RQ, 0.2 [0.2] for both). Filipinx Americans accounted for more than half of Asian American registered nurses and nursing assistants, with high relative representation (mean [SD] RQ, 5.6 (0.3) and 2.9 [0.4], respectively). Bangladeshi and Chinese American relative representation were high among home health aides (mean [SD] RQ, 4.1 [1.5] and 2.7 [0.5], respectively). Asian American individuals accounted for an estimated 22% of physicians (approximately 260 693 respondents), 10% of registered nurses (approximately 420 418 respondents), 4.8% of nursing assistants (approximately 93 913 respondents), and 8.3% of home health aides (approximately 60 968 respondents) in 2022. Conclusions and Relevance By examining disaggregated data, this study found persistent inequities among Asian American subgroups in the health workforce. Reducing Asian American populations to a single racialized group erases subgroup differences rooted in histories of racism, colonialism, and xenophobia; enables false narratives of Asian American overrepresentation and success; and hampers progress in advancing health justice.
Consumption of aspartame and risk of breast cancer in the Nurses’ Health Studies
Authors: Andrea Romanos-Nanclares, Eva Schernhammer, Walter C Willett, Michelle D Holmes, Wendy Y Chen, A Heather Eliassen
Journal: JNCI Journal of the National Cancer Institute (2024)

Debate persists regarding the potential carcinogenicity of aspartame as suggested by experimental studies. Therefore, we prospectively evaluated whether aspartame consumption is associated with breast cancer risk in the Nurses' Health Study (NHS) and Nurses' Health study II (NHSII). We used Cox models to calculate HRs and 95% CIs. During up to 30 years of follow-up with 4-yearly assessments of intake, we documented 10,814 invasive breast cancer cases. Overall, there was no association between aspartame consumption and invasive breast cancer risk (HR per 200 mg/day [approximately one 12 oz serving of diet soda] = 1.00 (95% CI 0.98, 1.03). We observed similar lack of associations after excluding cases occurring in the first 10 years of follow-up (n = 3,125) (HR per 200 mg/day 1.00, 95% CI 0.97, 1.03). In these cohorts, aspartame consumption did not increase breast cancer risk.
Effect of Electric Fans on Body Core Temperature in Older Adults Exposed to Extreme Indoor Heat
Authors: Fergus K. O’Connor, Robert D. Meade, Katie E. Wagar, Roberto C. Harris-Mostert, Emily J. Tetzlaff, James J. McCormick, Glen P. Kenny
Journal: JAMA (2024)

This study assessed whether electric fans limit core temperature increases in adults aged 65 to 85 years exposed to conditions similar to those experienced in homes during heat waves in North America.
Review of Chronic Pruritus—Reply
Authors: Gil Yosipovitch, Daniel Butler
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Air Pollution Exposure at Time of Lung Transplant and Survival: Can We Do Better?
Authors: Natalia Belousova, Chung-Wai Chow
Journal: JAMA Network Open (2024)

Olawale Amubieya, MD, PhD; Sam Weigt, MD; Michael Y. Shino, MD; Nicholas J. Jackson, PhD, MPH; John Belperio, MD; Michael K. Ong, MD, PhD; Keith Norris, MD, PhD
Person-Centered Care Planning for People Living With or at Risk for Multiple Chronic Conditions
Authors: Brittany N. Watson, Lilly Estenson, Aimee R. Eden, Maya T. Gerstein, Maria Torroella Carney, Vonetta M. Dotson, Trisha Milnes, Arlene S. Bierman
Journal: JAMA Network Open (2024)

Importance The US has a growing population of people living with multiple chronic conditions (MCC), yet the health system is ill designed to meet their needs. Person-centered care planning (PCCP) is an approach to provide comprehensive care that is responsive to the individual to improve health outcomes and increase value. Objective To examine strategies used to provide PCCP for people living with or at risk for MCC, as well as facilitators and barriers to implementation. Design, Setting, and Participants This qualitative study uses thematic analysis of responses from a Request for Information (RFI) published in the Federal Register soliciting input on PCCP, posted by the Agency for Healthcare Research and Quality (AHRQ) in 2022. The RFI was available for public comment from September 16, 2022, to November 15, 2022. Responses were analyzed between January 2023 and February 2024. Respondents were individuals and organizations who identify as, provide care for, or seek to improve care for individuals living with or at risk for MCC. Some responses represent multiple individuals. Main Outcomes and Measures Qualitative themes and subthemes of the RFI responses, developed using thematic analysis through inductive and deductive coding of the open-text responses. Results There were a total of 58 respondents, including clinicians, researchers, patients, caregivers, and representatives from health care payer, practitioner, health system, advocacy, professional, and supporting nonprofit and industry organizations. Researchers identified 9 themes: (1) suboptimal quality of care; (2) person-centered, goal-concordant care; (3) multidisciplinary team–based care and care coordination; (4) prevention across the life course; (5) digital health solutions; (6) workflow; (7) education and self-management support; (8) payment; and (9) achieving community, health system, and payer goals. Conclusions and Relevance In this qualitative study of PCCP for people living with or at risk for MCC, challenges to widescale adoption of PCCP were identified along with strategies to address these challenges, including the alignment of payment, policy support, culture change, adoption of meaningful measures, and the need for evidence on strategies to scale and spread PCCP. Insights gained from this analysis can inform research priorities and implementation efforts to advance PCCP as an integral component of routine care.
Considerations of Lay Health Worker Intervention Among Patients With Advanced Cancer—Reply
Authors: Manali I. Patel
Journal: JAMA Oncology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Lenvatinib Plus Ifosfamide and Etoposide in Children and Young Adults With Relapsed Osteosarcoma
Authors: Nathalie Gaspar, Giun-Yi Hung, Sandra J. Strauss, Quentin Campbell-Hewson, Filemon S. Dela Cruz, Julia L. Glade Bender, Kyung-Nam Koh, Sarah B. Whittle, Godfrey Chi-Fung Chan, Nicolas U. Gerber, Sauli Palmu, Daniel A. Morgenstern, Alessandra Longhi, Fredrik Baecklund, Jun Ah Lee, Franco Locatelli, Catalina Márquez Vega, Katherine A. Janeway, Geoffrey McCowage, Martin G. McCabe, Behzad Bidadi, Jie Huang, Jodi McKenzie, Chinyere E. Okpara, Francisco Bautista, Joseph Pressey, Carrye Cost, AeRang Kim, Elyssa Rubin, Melissa Bear, Katharine Offer, Gregory Friedman, Kelly Vallance, Anderson Collier, Scott Borinstein, Patrick Leavey, Albert Kheradpour, Kieuhoa Vo, Leo Kager, Bram De Wilde, Morgane Cleirec, Isabelle Aerts, Marion Gambart, Marie-Dominique Tabone, Cyril Lervat, Joy Benadiba, Cecile Verite, Ludovic Mansuy, Arnauld Verschuur, Natacha Entz-Werle, Cristina Meazza, Daniela Cuzzubbo, Loredana Amoroso, Alba Rubio San Simon (previous PI: Francisco Jose Bautista), Luis Gros Subias, Antonio Juan Ribelles, Ana Sastre Urgelles, Ricardo Lopez Almaraz, Moira Garraus Oneca, Javier Martin-Broto, Bruce Morland, Robert Philips, Milind Ronghe, Lisa Howell, Guy Makin, Shaun Wilson, Stephen Lowis, Michael Capra, Shirah Amar Yacobi, Natasha van Eijkelenburg, Torben Ek, Marie Ahlström, Manuel Diezi, Michal Zapotocky, Petr Mudry, Martin Campbell, Wayne Nicholls, Vivek Bhadri, Marianne Phillips, Herbert Loong, Mark Winstanley, Clement Korenbaum, Shui Yen Soh, Allen Yeoh, Mohamad Farid Harunal Rashid, Ji Won Lee, Hyoung Jin Kang, Minkyu Jung (Previous PI: Hyo Song Kim), Chih-Ying Lee (Previous PI: Giun Yi Hung), Shiann-Tarng Jou
Journal: JAMA Oncology (2024)

The combination of ifosfamide and etoposide (IE) is commonly used to treat relapsed or refractory osteosarcoma; however, second-line treatment recommendations vary across guidelines.
Considerations of Lay Health Worker Intervention Among Patients With Advanced Cancer
Authors: Kai Kang, Yijun Wu
Journal: JAMA Oncology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Challenges in Health Care for Persons With Multiple Chronic Conditions—Where to Go and How to Get There?
Authors: Gregory M. Ouellet, Jennifer A. Ouellet, Mary E. Tinetti
Journal: JAMA Network Open (2024)

Brittany N. Watson, MD, MPH; Lilly Estenson, MSW; Aimee R. Eden, PhD, MPH; Maya T. Gerstein, DrPH; Maria Torroella Carney, MD; Vonetta M. Dotson, PhD; Trisha Milnes, AuD, MHA; Arlene S. Bierman, MD, MS