tbuckley/cabot-search huggingface dataset:
Abstract 17954: Visceral Adiposity Index and Serum 25-OH Vitamin D: Insights from the NHANES-III
Authors: Tushar A Tuliani, Maithili Shenoy, Abhishek Deshmukh, Raxitkumar Jinjuvadia, Diane Levine
Journal: Circulation (2012)

Introduction: 25-OH Vitamin D (VD) deficiency has been linked to dysmetabolism. We sought to explore the relationship of VD deficiency and Visceral Adiposity Index (VAI) which correlates with visce...
Superior therapeutic effects of interleukin-12 and interleukin-18 gene transduced dendritic neuroblastoma fusion cells on liver metastasis of neuroblastoma
Authors: Hisae Iinuma, Kota Okinaga, Tsuyoshi Inaba, Kota Iwasaki, Taihei Koide, Ryoji Fukushima
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4335 

Neuroblastoma is characterized by aggressive local growth, followed by metastasis to the regional lymph nodes, liver and bone marrow. Although a few tumor- associated antigens of neuroblastoma, such as survivin, NY-ESO and MYC-N, have been reported, tumor specific antigens still remain unclear. Fusion vaccine of dendritic cells (DCs) and tumor cells has the advantage of inducing an immune response against multiple tumor antigens, including unknown tumor antigens. In this study, we assessed the protective and therapeutic effects of fusion cells transduced with the interleukin-12 (IL-12) gene and/or the interleukin-18 (IL-18) gene, employing the liver metastasis model of C1300 neuroblastoma cells. Pathogen-free A/J mice were purchased from Japan SLC, Inc. Murine neuroblastoma C-1300 originating in A/J mice was maintained in RPMI 1640 medium. IL-18, IL-12 or LacZ gene was transduced to DCs or tumor cells using the adenovirus vector. For fusion cells, three fusion methods - polyethylene glycol treatment, electrofusion, and a combination of PEG and electrofusion - were examined. Improving the fusion method by combining polyethylene glycol and electroporation increased loading efficiency. In the mice vaccinated with fusion cells modified with the LacZ gene (fusion/LacZ), IFN-γ production and cytotoxic T lymphocyte (CTL) activity increased significantly compared with that of DCs/LacZ, C1300/LacZ, or a mixture of the two (mixture/LacZ). With the transduction of IL-12 and IL-18 genes into the fusion cells (fusion/IL-12/IL-18), the level of IFN-γ increased more than five times that of other fusion groups. In addition, NK cell activity and CTL activity increased significantly compared with that of mixture/LacZ, fusion/LacZ, DC/LacZ, or C1300/LacZ. In the protective and therapeutic studies of fusion cell vaccine, mice vaccinated with fusion/LacZ, fusion/IL-12, fusion/IL-18, or fusion/IL-12/IL-18 showed a significant decrease in liver metastasis and a significant increase in survival compared with mice given a mixture/LacZ, DCs/LacZ, or C1300/LacZ. In particular, the mice receiving fusion/ IL-12/IL-18 vaccine showed a complete protective effect and the highest therapeutic effects. These results indicate that the improved loading efficiency of fusion cells and suggest that the introduction of IL-12 and IL-18 genes can induce extremely strong protective and therapeutic effects on liver metastasis of neuroblastoma.
Abstract 11328: Non-invasive Evaluation of Regional Kidney Oxygen Tension (PO2) with Circulating Perfluorocarbon (PFC) Nanoparticles (NP) and 19F MRI
Authors: Lingzhi Hu, Xiaoxia Yang, Junjie Chen, Shelton D Caruthers, Gregory M Lanza, Samuel A Wickline
Journal: Circulation (2011)

Atherosclerotic kidney disease is an important cause of hypertension and renal dysfunction. The renal medulla is highly susceptible to hypoxic injury due to the non-uniform blood flow distribution ...
K-ras/Ras effector alterations in colorectal cancers
Authors: Kimishige Akino, Kohzoh Imai, Reo Maruyama, Hiroaki Mita, Hiromu Suzuki, Takashi Tokino, Minoru Toyota
Journal: Cancer Research (2004)

Proc Amer Assoc Cancer Res, Volume 45, 2004

4979 

Numerous evidences have suggested that human cancers developed through the accumulation of epigenetic and genetic alterations. Recently, it is reported that genetic and epigenetic changes of RAS effecter proteins is associated with colorectal carcinogenesis. In this study, we investigate in great detail the occurrence and spectrum of epigenetic alteration of RASSF family (RASSF1-6) in colorectal cancer. Database analysis revealed that six RASSF family genes that contain Ras-association (RA) have CpG islands in their 5’ end. Among six genes, RASSF2 was most frequently silenced by hypermethylation of 5’ CpG island in colorectal cancer (CRC) cell lines (7/10, 70%). Treatment of cancer cells with a methyltransferase inhibitor, DAC, but not with a histone decatylase inhibitor, TSA induced gene expression. To investigate alteration of RAS signaling pathway in primary CRCs, we analyzed genetic and epigenetic changes of K-ras, BRAF and RASSF1-RASSF6 in a series of primary colorectal cancers and colorectal adenomas. Hypermethylation of RASSF2 was found in 51 of 122 (42%) primary colorectal cancers and 21 of 49 (43%) adenomas, and primary colorectal cancers with CIMP+ showed significantly more frequent RASSF2 methylation than CIMP- tumors (P<0.001). Eighty-five of 122 (70%) primary colorectal cancers showed at least one alteration in RAS/BRAF/RASSF1-6, indicating that a majority of CRCs showed defects in RAS signaling pathway. Transfection of RASSF2 to CRC cell lines induced apoptosis and inhibited cell growth by colony formation assay. These results suggested that RASSF2 is one of the most frequently silenced RAS signaling molecules in CRC and RAS signaling pathway can be a good molecular target for therapy in colorectal carcinogenesis.
Blood Lead Levels in Young Children--United States and Selected States, 1996-1999
Authors: J. P. Lofgren, M. Macias, S. Russakow, R. Gergely, B. McPartland, M. Amrich, J. Krueger, M. Silverman, I. Caceres, J. Wooldridge, D. Symonik, M. Falken, M. Stout, T. Krantz, T. Ward, E. Norman, N. Twitchell, C. Eccleston, J. Raucci, T. Alexander, I. Stevens-Dickerson, J. T. Braggio, A. Fletcher, W. Ball, S. Lynn, M. Mueller
Journal: JAMA (2001)
Abstract 3893: Endpoint Comparisons in an Advanced Heart Failure Trial: Data From the ESCAPE Trial
Authors: Christopher O'Connor, Mona Fiuzat, Joseph Rogers, Gudaye Tassisa, Victor Hasselblad, G. Michael Felker
Journal: Circulation (2009)

Background: The selection of endpoints in HF trials can affect the outcome of the trial, and optimal endpoints have been widely debated. The use of a composite endpoint may have potential disadvant...
7E3 F(ab′)2 , a Monoclonal Antibody to the Platelet GPIIb/IIIa Receptor, Protects Against Microangiopathic Hemolytic Anemia and Microvascular Thrombotic Renal Failure in Baboons Treated With C4b Binding Protein and a Sublethal Infusion of Escherichia coli
Authors: F.B. Taylor, B.S. Coller, A.C.K. Chang, G. Peer, R. Jordan, W. Engellener, C.T. Esmon
Journal: Blood (1997)
Cases are "unavoidably unpredictable"
Authors: P. Bingham, P. Old
Journal: BMJ (1996)

series is not the method of choice: to show an association between use of penicillin and a decreased frequency of meningococcal disease in close contacts a controlled study is required.It should also be noted that a recent monograph on meningococcal disease states that the use of penicillin in Norway to prevent secondary infec- tion "is no longer recommended."3In conclusion, there is no evidence to support the use of penicillin, with or without chemoprophylaxis, to reduce the risk of close contacts developing meningococcal disease.We fear that the only effect of this editorial will be to confuse general practitioners and others who may not be well acquainted with the subject.In our opinion the BMJ should instead have given prominence to the recent guidance on meningococcal disease issued by the Public Heath Laboratory Service's Meningococcal Infections Working Group.
Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury
Authors: Elizabeth Nance, Michael Porambo, Fan Zhang, Manoj K. Mishra, Markus Buelow, Rachel Getzenberg, Michael Johnston, Rangaramanujam M. Kannan, Ali Fatemi, Sujatha Kannan
Journal: Journal of Controlled Release (2015)
Abstract 14306: Relationship Between Left Ventricular Hypertrophy, Diastolic Function and Outcomes in African Americans With Hypertensive Chronic Kidney Disease: Results From the African American Study of Kidney Disease (AASK) Cohort Study
Authors: Gail E Peterson, Tine de Backer, Gabriel Contreras, Xuelei Wang, Cynthia Kendrick, Tom Greene, Lawrence J Appel, Otelio S Randall, Janice Lea, Miroslaw Smogorzewski, Tudor Vagaonescu, Robert A Phillips
Journal: Circulation (2011)

Background: African Americans with hypertension are at high risk for adverse outcomes from cardiovascular and renal disease. Patients with stage 3 or greater chronic kidney disease (CKD) are at inc...
Arboviral Diseases—United States, 1992
Authors: W. G. Hlady
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 8649: Aerobic Exercise Training Improves Heart Rate Variability, as Reflected by PD2i, in Individuals with Low PD2i
Authors: Daniel N Weiss, Stella Goulopoulou, James E Skinner, Anchin M Jerry, Jill A Kanaley
Journal: Circulation (2011)

Point Correlation Dimension (PD2i) is a non-linear measure of heart rate variability complexity that has been shown to be able to predict the risk of sudden arrhythmic death, such that a value ≤ 1.4 increases risk substantially, with a value ≤2 denoting the presence of autonomic dysfunction. It is unclear, however, if exercise, a lifestyle behavior recommended to sedentary individuals, can favorably alter PD2i. The purpose of this study was to determine if 16 weeks of moderate intensity aerobic exercise training would raise PD2i in sedentary lean and obese, middle aged men and women (age 40-57 yr). PD2i was measured at rest and in response to 5 min of upright tilt pre and post the 16 week exercise training regimen. Subjects were stratified into 2 groups according to their pre-regimen resting PD2i: low PD2i≤ 2 (lPD2i, n=14) and normal PD2i &gt;2 (nPD2i, n=45 ). At rest, there was a training by group interaction such that PD2i increased substantially with exercise training in the lPD2i group but not in the nPD2i group (lPD2i pre 1.94±0.2, post 2.46±0.2; nPD2i pre 2.95±0.1, post 3.0±0.09, P=0.02). In response to the sympathetic stress of upright tilt (known to acutely lower PD2i), both groups had an appropriate decrease in PD2i (P&lt;0.001) and an overall effect of training (P=0.04), but there was no training by group interaction on this response. During recovery from tilt, the lPD2i group had a significant improvement in PD2i with training (lPD2i pre 2.21±0.2, post 2.92±0.2; nPD2i pre 3.26±0.1, post 3.22±0.1, P=0.009), while there was no change in the nPD2i group. In conclusion, a 16 wk moderate intensity training program improves resting and recovery PD2i in those with low initial resting values, and this improvement may reduce their risk of sudden arrhythmic death.
Abstract 16782: Contribution of the Primary Arrhythmia Syndromes to Sudden Cardiac Arrest in the General Population: Prospective, 8-Year Study in a Large US Community
Authors: Ragesh Panikkath, Audrey Uy-Evanado, Kyndaron Reinier, Carmen Teodorescu, Harpriya Chugh, Jo Ayala, Ronald Mariani, Lynn Wittwer, Karen Gunson, Jonathan Jui, Sumeet S Chugh
Journal: Circulation (2011)

Introduction: While some estimates are available for the burden of the primary arrhythmia disorders such as long QT syndrome and hypertrophic cardiomyopathy, systematic, prospective evaluations in populations of adequate size are lacking. Methods: We evaluated the frequency of SCA due to primary arrhythmia syndromes in an ongoing community-based study of one million residents in the northwestern US (2002-09). Analysis was restricted to cases of SCA (non-survivors plus survivors), age&gt;10 years. We performed a detailed analysis of the available electrocardiograms, pre-mortem medical records as well as post-mortem evaluation. Results: A total of 1537 SCD cases enrolled during the study period had adequate information available for analysis. Among patients ≥ 35 years, 44.6% had medically documented significant CAD. While postmortem examination was performed in only 17% of total cases, autopsy findings among that subset and from previous postmortem studies of SCD patients indicate that a large majority (&gt;80%) of the remainder of subjects is also likely to have CAD. However, a primary arrhythmia syndrome was diagnosed or apparent on ECG in 3% of all cases, with frequencies as follows: Hypertrophic cardiomyopathy (n=20; 1.3%), idiopathic VF (n=21; 1.4%), long QT syndrome (n=2; &lt;1%), ECG evidence of Brugada pattern (n=2; &lt;1%) and ARVD (n=1; &lt;1%). No cases were identified as short QT syndrome or catacholaminergic polymorphic ventricular tachycardia. Conclusions: Primary arrhythmia syndromes contributed to at least 3% of all SCD cases in this US community. Given the study design, this likely represents the lower limit of prevalence.
Review on bladder cancer
Authors: J. Millar, A P M van der Meijden
Journal: BMJ (1999)

Editor—The review on bladder cancer includes an incorrect diagram of the TNM staging system and neglects any reference to the hope of improved outcomes with concurrent radiation and chemotherapy.1 The diagram shows the previous TNM (fourth edition) T categories2 rather than the new (fifth edition) system.3 The new system categorises all muscle invasion without perivesical invasion as T2. T2a is invasion of the “inner half” and T2b is invasion of the “outer half.” Any perivesical invasion leads to T3 categorisation, which is also subcategorised: T3a is microscopic invasion beyond the muscle; T3b is an “extravesical mass.”

The review summarises the evidence for little useful effect of either neoadjuvant or adjuvant chemotherapy in patients with muscle invasive bladder cancer managed surgically. It neglects, however, one promising avenue of multimodality treatment: concurrent chemotherapy and radiation. Several studies show that this approach has survival rates and local control rates comparable to those in surgically managed patients but conserves good bladder function in most patients.4,5 Completion of randomised controlled trials to evaluate this approach is essential.
Abstract A90: Non-canonical effects of PTEN restoration therapy contribute to improved survival in a GEM model of pancreatic ductal adenocarcinoma
Authors: Benjamin Hopkins, Carmine Palermo, Roshan A. Ahmed, Stephen A. Sastra, Ramon Parsons, Kenneth P. Olive
Journal: Cancer Research (2015)

Abstract Expression of the PTEN tumor suppressor protein is frequently altered in human pancreatic tumors, and deletion of PTEN in genetically engineered mouse (GEM) models accelerates pancreatic tumorigenesis. However, efforts to target components of the PTEN pathway, through inhibitors of PI3-Kinases, AKT, or mTOR, have failed to provide significant survival benefit to date. We utilized a naturally occurring, membrane-permeable variant of the PTEN protein, called PTEN-Long, to restore PTEN-function in trans to established pancreatic tumors in the KPC GEM model of pancreatic ductal adenocarcinoma (PDA). Combination PTEN-Long + gemcitabine therapy prolonged overall survival by 2-fold in this model and led to frank regressions of varying duration in a subset of tumors. In order to study the mechanisms of response to PTEN-Long therapy, we utilized variants of the PTEN-Long protein that are functionally mutated in different ways. A phosphatase-dead variant of PTEN-Long failed to have any effect on tumor growth in KPC mice. Interestingly, a variant of PTEN-Long that is no longer membrane permeable actually reduced overall survival in combination with gemcitabine, perhaps indicating a role for the protein in the extracellular matrix. Finally, we compared the effect of PTEN-Long in KPC mice to that of the pan-PI3K inhibitor GDC-0449. In contrast to PTEN-Long + gemcitabine, GDC-0449 + gemcitabine failed to extend survival or produce tumor regressions. Investigating the distinctions between pan-PI3K inhibition and PTEN restoration, we noted disparate, indeed opposite, effects of these two therapies on blood glucose maintenance and insulin levels, strongly that PTEN can function though additional, non-canonical intermediates beyond phospho-inositides. With the development of a clinical grade PTEN-Long material under way, we believe that these studies highlight the potential therapeutic utility of PTEN restoration therapy in PDA. These experiments provide the opportunity to dissect non-canonical aspects of PTEN signalling through in vivo structure/function analysis in GEM models of pancreatic cancer. Citation Format: Benjamin Hopkins, Carmine Palermo, Roshan A. Ahmed, Stephen A. Sastra, Ramon Parsons, Kenneth P. Olive. Non-canonical effects of PTEN restoration therapy contribute to improved survival in a GEM model of pancreatic ductal adenocarcinoma. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2015;75(13 Suppl):Abstract nr A90.
Abstract 19167: Can Variation of BNP Within the Normal Range Predict Mortality and Ischemic Events in a Secondary Prevention Population? Results From the Smart Cohort Prospective Registry Study
Authors: Marrieke Hillaert, Eef G Lentjes, Hans Kemperman, Hendrik M Nathoe, Pierfrancesco Agostoni, Michiel Voskuil, Pierre Vladimir Ennezat, Brigitte Jude, Yolanda van der Graaf, Pieter A Doevendans, Eric Van Belle
Journal: Circulation (2010)

It is unclear whether variation of BNP levels within the normal range can predict long term mortality and cardiac ischemic events in secondary prevention population without heart failure. Methods and Results: Baseline BNP levels were measured in 2115 subjects (mean age 61±10 years, 81% male) with stable coronary artery disease (CAD) recruited in an outpatient clinic. During a mean follow-up of 4.0 years, the primary endpoint of cardiovascular (CV) mortality occurred in 145 (6.9%) patients. Total mortality occurred in 207 (9.8%) patients. Cardiac ischemic events (fatal and non-fatal acute MI, PCI and CABG) occurred in 410 (19.4%) patients. The low mortality rate (2%/year), the low median BNP level (12 pmol/L, IQR 6-24 pmol/L) and the low median hsCRP level (2 mg/L, IQR 1-4 mg/L) reflect the low risk profile of the population. BNP levels were positively associated with age (p=0.0001), CRP (p=0.01) and creatinine (p=0.0001) and inversely correlated with BMI (p=0.0001). They were higher in females (p=0.007), ...
Effect of Bone Marrow Culture &lt;italic&gt;In Vitro&lt;/italic&gt; on Its Protective Action in Irradiated Mice&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Daniel Billen
Journal: JNCI Journal of the National Cancer Institute (1959)

Mouse bone marrow cells tissue-cultured in a special container have been studied in an attempt to identify the cells responsible for the protection afforded recipient, lethally irradiated mice, by bone marrow post treatment. After 4 days of culture, a decreased protective activity of injected tissue-cultured cells was observed. By the 9th day of life in vitro, the explanted bone marrow cells had essentially lost their protective capacity. Analysis of the cell species present at this time showed that several stem-cell types persisted in such negative cultures. These findings are discussed in relation to the mechanism of protection of recipient mice, with bone marrow.
Abstract 15531: Neuregulin-1{beta} Improves Cardiac Remodeling After MI in Swine
Authors: Ehab Kasasbeh, Abigail Murphy, Phillip Williams, Amy Nunnally, Jamie Adcock, Anthony Caggiano, Thomas Parry, Anandita Ganguly, Douglas B Sawyer, John H Cleator
Journal: Circulation (2011)

Neuregulin-1β (NRG-1β) is a growth factor that is critical for cardiac development. In the adult heart NRG-1β is a stress-activated mediator of cardiac repair after injury which led to the developm...
Extrapyramidal symptoms due to dopamine-blocking agents in patients with AIDS encephalopathy
Authors: E Hriso, T Kuhn, J C Masdeu, M Grundman
Journal: American Journal of Psychiatry (1991)

The authors attempted to determine whether patients with AIDS are more susceptible to neuroleptic side effects than other patients.Retrospective chart review was used to assess the frequency and severity of extrapyramidal symptoms in patients with AIDS and psychotic patients without AIDS who had taken dopamine-blocking agents. The charts of 804 men younger than 50 years were reviewed, and patients were excluded if they had not taken dopamine blockers, had taken them for more than 1 month, had received concomitant antiparkinsonian agents, had focal brain lesions or histories of Parkinson's disease or meningitis, had used cocaine, amphetamines, or opiates within 1 month of admission, or, among the comparison group, had HIV risk factors. For the remaining 31 AIDS and 32 comparison patients, age, duration of dopamine blocker treatment, dose in chlorpromazine equivalents, and nature and severity of parkinsonian complications were recorded.The mean drug dose and body weight were significantly lower in the AIDS group. The likelihood of developing extrapyramidal symptoms was 2.4 times as high among the AIDS patients as among the comparison group. Such symptoms were developed by 50% of the AIDS patients who received less than 4 mg/kg of chlorpromazine equivalents per day and 78% of those who received more than 4 mg/kg per day.These preliminary results suggest that AIDS patients are more susceptible to extrapyramidal symptoms than psychotic patients without AIDS and that neuroleptics should be used cautiously and in lower doses for patients with AIDS.