tbuckley/cabot-search huggingface dataset:
Amish Study, III: the impact of cultural factors on diagnosis of bipolar illness
Authors: J A Egeland, A M Hostetter, S K Eshleman rd
Journal: American Journal of Psychiatry (1983)

In the Amish Study of affective disorders, 79% of the 28 active bipolar I patients, diagnosed according to Research DIagnostic Criteria, previously had received hospital record diagnoses of schizophrenia. Both cultural and clinical factors hindered correct diagnosis, and cultural influences particularly complicated the interpretation of the manic symptoms of grandiosity and excessive involvement in activities. Other factors central to misdiagnosis were form of thought (flight of ideas), content of thought (grandiose and religious delusions), paranoid features, and the failure to recognize the presence of a manic syndrome.
Abstract 14895: In-Situ Simulation Shows Challenges for 2-Minute Defibrillation Practice Standard
Authors: Richard L Fidler, Breanne Cisneros, John Ryan, Trese Biagini, Brian A Cason
Journal: Circulation (2011)

Background: Early defibrillation and quality compressions have been shown to improve survival after VT/VF arrest. Early chest compressions and defibrillation within 2 minutes of cardiac arrest impr...
Abstract 1822: Impact on Anxiety of an Education and Counseling Intervention Designed to Decrease Treatment Seeking Delay in Response to Acute Coronary Syndrome (ACS) Symptoms
Authors: Debra K Moser, Sharon McKinley, Barbara Riegel, Lynn V Doering, Hendrika Meischke, Michele Pelter, Kathleen Dracup
Journal: Circulation (2007)

Background: Patient delay in seeking treatment for ACS symptoms remains a substantial problem with most people delaying more than 2 hours before they seek treatment. Thus, it is vital to test interventions to improve this behavior, but at the same time it is essential that such interventions not increase anxiety. Given that these interventions seek to decrease patient denial of the seriousness of symptoms, it is possible that they may increase anxiety. Purpose: To determine the impact on anxiety of an individual face-to-face education and counseling intervention designed to decrease patient delay in seeking treatment for ACS symptoms. Methods: This was a multicenter randomized (intervention vs. usual care) controlled trial of the intervention in which anxiety data were collected (using the Multiple Affect Adjective Checklist) at baseline, 3-months and 12-months after the intervention. A total of 3522 patients with confirmed coronary artery disease (CAD) who were at risk for ACS were enrolled; data from 2597 patients with complete anxiety data at all three time points are included here. There were no differences in patients completing all three time points and those who did not. The intervention consisted of a 45 minute education and counseling session, reinforced by a phone call one month later in which the social, cognitive and emotional responses to ACS symptoms were discussed as were barriers to early treatment seeking. Repeated measures ANCOVA was used to compare anxiety levels across time between the groups controlling for age and gender. Results: There were significant differences in anxiety by group (p = 0.014). Anxiety level was stable in patients in the control group, but decreased by 10% at 3 months in the intervention group and remained at this reduced level at 12 months. Conclusion: An intervention designed to reduce patient delay in seeking treatment for ACS symptoms did not increase anxiety, but rather was associated with a reduction in anxiety. Interventions in which CAD patients directly confront the possibility of an acute cardiac event do not cause anxiety if they provide patients with appropriate strategies for managing symptoms.
超声引导的中心静脉穿刺技术——是初学者、小儿患者以及盲探置管失败时的有益选择
Authors: 胡建华
Journal: BMJ (2003)

颈椎病的治疗分为非手术治疗和手术治疗.非手术治疗不能简单称之为保守治疗,它是各种类型颈椎病治疗的基本方法和手术治疗的基础,具有积极的治疗意义.神经根型、椎动脉型和交感型颈椎病主要行非手术治疗.当非手术治疗半年无效或影响正常生活和工作;或神经根性疼痛剧烈经非手术治疗无效;或上肢肌肉尤其手内在肌萎缩、无力,经治疗4～6周仍有发展趋势者,应采取手术治疗.由于脊髓型颈椎病疾病自然史显示症状将逐渐发展加重,所以确诊后应及时手术治疗。
ROLE OF THE THYMUS IN IMMUNE REACTIONS IN RATS
Authors: Branislav D. Janković, Byron H. Waksman, Barry G. Arnason
Journal: The Journal of Experimental Medicine (1962)

Rats thymectomized at birth gained weight and otherwise developed normally, but were found to be very susceptible to intercurrent infections. Both Arthus reactivity and delayed hypersensitivity to BSA were markedly impaired in rats thymectomized during the first week of life and significantly impaired in rats thymectomized as late as 3 weeks after birth. The inhibition of Arthus reactivity in thymectomized rats was well correlated with their failure to develop significant titers of precipitating or hemagglutinating antibody. However, natural heteroagglutinin titers were not altered in these animals, and no abnormality of serum proteins, including gamma-globulin could be detected by paper electrophoresis. The loss of immunologic activity could not be corrected by injecting homogenates of spleen or thymus before and during the sensitization period. Splenectomy at birth did not influence Arthus or delayed reactivity.
Abstract 16190: Master Cardiac Transcription Factor MESP1 is Highly Expressed in Adult Human CD34+ Hematopoietic Stem Cells and its Levels are Modulated by Body Mass Index
Authors: Thomas R Cimato, Beth A Palka, Jennifer K Lang
Journal: Circulation (2013)

Background:  Adult human CD34+ stem cells (SCs) differentiate to both blood and vascular cell lineages, and may have benefit in ischemic heart and limb disease. Given the similar differentiation potential of CD34+ SCs with embryonic hemangioblasts, the objective of our study was to determine if adult human CD34+ SCs utilize a similar molecular mechanism to differentiate as found in development.   Methods:  Human CD34+ lin- SCs were sorted from bone marrow (BM), and peripheral blood (PB) mononuclear cells from twelve subjects without heart disease. Colony forming assays confirmed differentiation to blood lineages. Unsorted pBMNCs were retained as a non-stem cell, negative control. Total RNA was extracted from equal numbers of cells, and quantitative PCR (qPCR) for relative transcript expression. qPCR data was normalized to two invariant transcripts using the ΔΔCt method, and significant differences in transcript levels determined by ANOVA. Univariate analyses identified correlations in transcript level with clinical variables (age, sex, BMI, blood pressure), and significance determined by Pearson’s correlation.   Results:  Transcript levels of CD34, CD133, TAL1/SCL and MIXL1 were present at 20 fold higher levels in CD34+ SCs from BM and PB relative to unsorted pBMNCs. VEGFR2, but not Neuropilin-1, was abundantly expressed (14 fold higher, p    Conclusions:  The master cardiac transcription factor MESP1 is abundantly expressed in adult human CD34+ stem cells, and MESP1 mRNA inversely correlates with body mass index. The findings represent novel evidence for the embryonic transcription factor MESP1 in the biology of adult human CD34+ SCs, and suggest obesity decreases MESP1 levels.
Abstract 1371: Markers and Mediators of Autophagy Are Increased in the Hearts of Two Murine Models of Type 2 Diabetes Irrespective of Cardiac Function
Authors: Kari A Wellnitz, Raffaella Lombardi, Rebecca L Salazar, Heinrich Taegtmeyer
Journal: Circulation (2009)

The excess supply of fuels to the diabetic heart results in dysfunctional mitochondria and oxidized proteins. Autophagy, a pathway for lysosomal degradation of organelles and proteins, has been sho...
An Anti-Intellectual Movement in Medicine?
Authors: R H Moser
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Indian health officials probe use of "unapproved" treatment
Authors: Ganapati Mudur
Journal: BMJ (2001)

Indian health officials are investigating the circumstances in which private doctors injected an experimental treatment agent into patients with coronary disease, although India had not approved the product for either treatment or trials.

Doctors at the Metro Hospital and Research Centre in a New Delhi suburb injected vascular endothelial growth factor into at least 16 patients with advanced coronary artery disease between early 1998 and mid-2000.

Medical teams in the United States pioneered the use of growth factors to stimulate the formation of new blood vessels in the late 1990s, and its use in India was defended by …
综述：尼古丁替代疗法辅助“逐渐减量法”可使吸烟者减少吸烟和维持戒烟
Authors: Moore, Aveyard, Connock, 江琪琪
Journal: BMJ (2010)

综述范围 纳入的研究比较了使用口香糖或吸入剂的尼古丁替代疗法（NRT）与没有治疗、非NRT的药物治疗或心理干预，在不愿意或无法突然停止吸烟者中戒烟的疗效。辅助疗法在两个治疗组均须包括。主要结果是持续6个月戒烟。其他结果是，持续减少吸烟或戒烟从6周到研究结束和不良事件。
Development of novel small molecule inhibitors targeting CXCR4 against cancer metastasis
Authors: Zhongxing Liang, Weiqiang Zhan, Younghyoun Yoon, Ghazala Datoo, James Snyder, Dennis Liotta, Hyunsuk Shim
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4742 

The intended objective is the identification of small molecules that will attenuate tumor metastasis in vivo by blocking CXCR4 function whilst demonstrating a sufficient pharmacokinetic and specificity profile to merit advancement into human clinical evaluation. Even though CXCR4 is a good target for intervening various diseases, especially, cancer metastasis, there is no safe drug in the clinic until now. Metastasis is an end result for many solid tumor types and is the leading cause of cancer related deaths. This has attracted an increasing amount of attention from research groups over the last decade in both academia and industry, as a target for metastatic disease intervention and life extension. To date, a number of target molecules have been addressed that are linked mechanistically to the various sub-steps associated with metastasis including: i) establishment of angiogenesis at the primary site; ii) locomotion; iii) chemoattraction, homing, and adhesion of the metastatic cells to the defined organs; and iv) establishment of metastatic tumor growth and angiogenesis. The CXCR4/SDF-1 interaction, and the resulting cell signaling cascade, has recently emerged as one of the most relevant such targets as it has been shown to play a key role in all four steps outlined above. A set of small molecule CXCR4 antagonists have been discovered and we are currently in the process of evaluating specificity and potency. WZ40 is currently the most advanced, which potently bind to CXCR4, thus, blocking the CXCR4/SDF-1 signaling process. We have followed this discovery by demonstrating that WZ40 inhibits tumor metastasis by inhibiting the CXCR4/SDF-1 interaction in both in vitro and in vivo studies. Notes: Z. Liang and W. Zhan contributed equally to this work.
Abstract 17139: Hereditary Transthyretin Amyloidosis With Exclusive Cardiac Phenotype: A Multicenter Italian Study
Authors: Candida C Quarta, Laura Obici, Stefano Perlini, Simone Longhi, Giovanni Palladini, Francesco Musca, Francesco Salinaro, Alessandra Ferlini, Fabrizio Salvi, Caterina Villani, Christian Gagliardi, Pamela Gallo, Francesca Mingardi, Angelo Branzi, Giampaolo Merlini, Claudio Rapezzi
Journal: Circulation (2010)
Multistage pH-responsive mucoadhesive nanocarriers prepared by aerosol flow reactor technology: A controlled dual protein-drug delivery system
Authors: Neha Shrestha, Mohammad-Ali Shahbazi, Francisca Araújo, Ermei Mäkilä, Janne Raula, Esko I. Kauppinen, Jarno Salonen, Bruno Sarmento, Jouni Hirvonen, Hélder A. Santos
Journal: Biomaterials (2015)
Abstract 15699: Matrix Metalloproteinase-9 Overexpression in Macrophages Improves Ventricular Function by Regulating the Inflammatory and Fibrotic Responses Post-Myocardial Infarction
Authors: Rogelio Zamilpa, Trevi A Ramirez, Jessica Ibarra, Qiuxia Dai, Tariq Dayah, Nguyen Nguyen, Jianhua Zhang, Seema S Ahuja, Jeanine D'Armiento, Yu-Fang Jin, Merry L Lindsey
Journal: Circulation (2011)

Macrophage activation post-myocardial infarction (MI) influences the extent of left ventricular remodeling. Post-MI, activated macrophages infiltrate into the injured myocardium to provide a robust...
Giant inflammatory pseudotumor of the larynx treated endoscopically by a gastroenterologist using submucosal dissection
Authors: Marcel Tanţău, Lidia Ciobanu, Teodor Zaharie, Gabriela Mester, Alina Tanţău
Journal: Endoscopy (2015)

Submucosal pedunculated masses of the hypopharynx, larynx, and upper esophagus pose diagnostic and treatment challenges for gastrointestinal endoscopists. Because of potentially acute respiratory complications, the removal of these pedunculated masses through a transoral, transcervical, transthoracic, or endoscopic approach, depending on their location and size, is mandatory [1].
Abstract 12780: Reduced Skeletal Muscle Lipid Uptake Affects Cardiac Substrate Metabolism and Leads to Cardiomyopathy
Authors: Hong Wang, Kelly Ambler, Ira J Goldberg, Robert H Eckel
Journal: Circulation (2010)

Skeletal muscle lipid content correlates with insulin action, however, effects of alterations of lipid metabolism in skeletal muscle on cardiac function have not been shown. Lipoprotein lipase (LPL...
Malignant Melanoma and Soft Tissue Sarcomas
Authors: C. Menzel, H. Palmedo, F. Grünwald, H. -J. Biersack
Journal: Clinical Nuclear Medicine (2008)

Malignant melanoma (MM) of the skin has increased dramatically throughout the world during recent years. The overall increase in incidence has been dominated by new cases in the developed countries, with most patients being diagnosed in North America and Western Europe and, relative to population size, a large number of cases in Australia and New Zealand. While it is obvious that a combination of light-colored populations and increasing exposure to ultraviolet radiation has led to an increased risk of the development of malignant melanomas, it remains largely unknown in detail which factors are responsible for the transformation of a rarely proliferating melanocyte into a highly aggressive, often fatal tumor. Recently it has been shown that surface anomalies on the melanoma cells are responsible for a loosely bound architecture of tumor clones, leading to the easy development of metastatic disease. For these reasons there is an increasing need for advanced diagnostic strategies and new therapy modalities.
Abstract 2616: Role of the Soluble Epoxide Hydrolase in Hypoxic Pulmonary Vasoconstriction and Pulmonary Vascular Remodeling
Authors: Benjamin Keserü, Beate Fisslthaler, Ingrid Fleming
Journal: Circulation (2008)

The soluble epoxide hydrolase (sEH), which is expressed in pulmonary artery smooth muscle cells, metabolizes cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) to their less active diols. Preliminary findings indicate a role of the sEH on hypoxic pulmonary vasoconstriction (HPV) and a vasoconstrictor role of EETs in the pulmonary vasculature. Here we assessed the influence of hypoxia on the expression of the sEH, acute HPV and pulmonary vascular remodeling. In lungs from wild-type mice (WT), exposure to hypoxia (FiO 2 = 0.1) for 21 days decreased the expression of the sEH by 70% (RT-PCR), and increased the number of partially and fully muscularised resistance arteries (by 3-fold). In isolated lungs, pre-exposure to chronic hypoxia significantly increased baseline perfusion pressures (1.3-fold) and potentiated the acute HPV (1.5-fold). While an sEH inhibitor (1-adamantyl-3-cyclohexylurea; ACU) potentiated acute HPV in lungs from mice maintained in normoxic conditions, it had no effect on HPV in lungs from mice exposed to hypoxia. The EET antagonist, 14,15-EEZE, abolished the sEH inhibitor-dependent increase in acute HPV in normoxic lungs. Under normoxic conditions the muscularization of small pulmonary arteries was greater in lungs from sEH −/− mice than in lungs from WT mice and chronic hypoxia further increased the number of fully and partially muscularized arteries in these animals. sEH −/− mice also displayed an enhanced acute HPV (1.5-fold), compared to that observed in WT mice and chronic exposure to hypoxia did not further potentiate acute HPV. Taken together, these data indicate that the sEH is involved in hypoxia-induced pulmonary vascular remodeling and hypoxic pulmonary vasoconstriction.
Hypoxic induction of gene expression in chronic granulomatous disease- derived B-cell lines: oxygen sensing is independent of the cytochrome b558-containing nicotinamide adenine dinucleotide phosphate oxidase
Authors: RH Wenger, HH Marti, CC Schuerer-Maly, I Kvietikova, C Bauer, M Gassmann, FE Maly
Journal: Blood (1996)
Book: Football Medicine
Authors: Nigel Sellars
Journal: BMJ (2004)

I did not need a second invitation to review a book entitled Football Medicine, two subjects dear to my heart—although my more cynical colleagues would no doubt say the former more than the latter. Aptly for a book of largely Swedish origin, and at the end of a historic unbeaten season for the mighty Gunners, their very own Freddie Ljungberg is in full flow on the front cover, although on a decidedly subdued hair day. The book's line up is impressive: forewords by Lennart Johansson, the president of the Federation Internationale de Football Association, and the one and only Sven-Goran Eriksson; and an extensive list of premier-ship quality contributors, including our own Alan Hodson, who should need no introduction to anyone interested enough to pick up a copy, and another adopted Swede, Leif Sward, our national team's doctor.​doctor.




Figure 1



Eds Jan Ekstrand, Jon Karlsson, Alan Hodson

Taylor & Francis, £60, pp 562 ISBN 1 84184 164 1

Rating: ★★★




The authors have valiantly attempted to cover a range of important topics in a clear and readable manner, but much of it is simplistic, to the extent that I was left wondering exactly who the book is aimed at. The title would seem to target the medical profession, but even those, like myself, who consider themselves first and foremost general practitioners, with their football medicine (with or without club attachment) as a special interest, will find much of it frustrating, in that it whets the appetite but leaves you unsatisfied. This is particularly true of the 180 pages on sports injuries. The bonus is the sheer array of topics, including injury prevention (with some interesting statistics), post-injury rehabilitation and testing, biomechanics, physiology, nutrition, foreign travel, and even, at the end (against naval etiquette), women and children.

Whether something has been lost in translation I am not sure, but although it's a stress free read the overall pace and tone are decidedly Sven: informative, polite, and charming, but dry to the point of monotone, with scarcely a word wasted in anger. It's almost a caricature of your average Briton's perception of your average Swede.

Should doctors without a special interest buy this book? I don't know. As an introductory text it is certainly suited to professionals wishing to familiarise themselves with the essentials of the subject. Would non-medically trained people benefit? Only if they have a passing interest and wish to know more. Anyone who has trained or is training in physiotherapy, nutrition, or sports science and so on would need more specialised information.

As with wine and golf I enjoy everything I read on the subject, and this book was no exception. It whiled away many a journey and many a hotel stay and provided relief from the interminable chewing of nails entailed in the relentless quest for premier-ship safety points. Well, Freddie, we're coming to do it all again—but will you get another standing ovation next season?
Abstract 12401: Prevention of Stent Grafts Restenosis by Pretreatment with Sirolimus Eluting Stent (SES)
Authors: Yongpeng Zou, Huai Yu, Xuefeng Ren, Jingbo Hou, Shaosong Zhang, Bo Yu, Ik-Kyung Jang
Journal: Circulation (2011)

Background: Stent grafts can be used for selected cases such as perforation, aneurysm, or severe late stent malapposition following drug eluting stent implantation. The main problem of stent grafts is restenosis from in-growth of neointima from stent edges. Objectives: To assess the novel approach of combination of SES and stent graft for prevention of restenosis. Methods: Between Jun 2008 and Dec 2010, 8 patients (2 for coronary perforation, 2 for aneurysm and 4 for late stent malapposition) were enrolled in this study. All culprit lesions were first treated with a longer SES (average length 29.9 mm and diameter 3.1mm) prior to implantation of a stent graft (average length 19.7 mm and diameter 3.4mm). All stents were fully expanded with high pressure post-dilatation. Coronary angiography and optical coherence tomography (OCT) were repeated at 8 month follow-up. Results: There was no angiographic restenosis (% diameter stenosis was 15.2±14.2% at 8 months) in stent graft segment. Neointima thickness was si...