tbuckley/cabot-search huggingface dataset:
Theatre: Thalidomide!! A Musical
Authors: Aula Abbara, Huda Al-Hadithy
Journal: BMJ (2006)

The thalidomide disaster of the 1960s and the subsequent cover ups of devastated lives is not the most obvious subject for a musical or even satire, yet this production works beautifully. Written by and starring Mat Fraser, who was a thalidomide baby, Thalidomide!! A Musical is a hilarious, poignant, and touching show that charts the life of Glyn (played by Fraser), and his quest for happiness with his childhood sweetheart, Katie (Anna Winslet), who is infatuated with him and his short arms. The two talented leads maintain the audience's interest throughout with their energy and inventiveness.

At the start a mock-chilling voiceover takes us through a brief history of thalidomide. Developed by Dr Heinrich Muekter (a Nazi party member) and subsequently marketed in 1957 by Chemie Grunenthal, a German, state funded pharmaceutical company, thalidomide was available as a sleeping pill and anti-emetic during pregnancy. However, it was not researched adequately and was responsible for the physical deformities of thousands of babies; what followed were denials by the drug company, which refused compensation and continued to profit from drug sales. More than 400 British infants born in the 1960s had phocomelia or amelia (birth defects in which there is absence or shortening of limbs), the talented, defiant Mat Fraser among them.​them.



Figure 1

A “PC-free musical with a short-armed punch”



Fraser's tone is both angry and humorous, his lyrics sardonic and occasionally bitter. The tunes and words are catchy and move from the dramatic “Monster babies, Monster babies, A vision from Hades, Worse than rabies” to the cringingly funny “It's Hard to Hitch Down Life's Highway With No Thumbs” to the touching ballad “I Can Be His Arms.”

This is an exhilarating production that takes the audience through a rollercoaster of emotions from guilt, tragedy, and despair to hilarity, and encompasses sign language, singing, salsa, tap dancing, and even puppetry. It is a manic run through Glyn's life, taking in his father's suicide after Glyn's birth and the horrified gasps from mothers at an antenatal class, with the two leads playing all characters at all stages. The funniest and most poignant is when they enter the awkward teenage and university years, and Glyn starts to question Katie's adulation, rejecting her desire “to help him reach the top shelf.” Bizarrely, the relationship is consolidated when Katie loses her arms in a car crash; it is unclear what Fraser seeks to portray with this twist in the story.

Billed as the “PC-free musical with a short-armed punch,” Thalidomide not only challenges its audience, but also calls into question the traditional range of topics deemed fit for musical theatre; for the most part, it is successful in its aims.
Abstract 2554: Natural History of Apical Hypertrophic Cardiomyopathy: Outcome Not as Benign as Previously Suspected
Authors: Christine H Attenhofer Jost, Josepha Binder, Kyle W Klarich, Steve R Ommen, Heidi M Connolly, Kent R Bailey, William K Freeman, Hartzell V Schaff, Rick A Nishimura, A. J Tajik
Journal: Circulation (2007)

Background. Apical hypertrophic cardiomyopathy (AHCM) has been considered a ``benign” form of HCM in Asian and non-Asian patients (pt). However, data on long-term outcome of pt with AHCM are limited. The purpose of this study was to determine the natural history of pt with AHCM followed at a tertiary referral center in North America. Methods. Between July 1976 and September 2006, 193 pt with the diagnosis of AHCM were seen at the Hypertrophic Cardiomyopathy Clinic. The last echocardiographic exam was reviewed in all pt. Follow-up data were obtained where possible (clinic visit). Results. Mean age at diagnosis 56±17 years, mean age at first presentation at our center was 58±17 years. Symptoms included chest pain in 69 pt (36 %), and exertional dyspnea ≥NYHA II in 97 pt (50 %). A family history of either HCM and/or sudden cardiac death was reported by 36 pt (19 %). Coronary artery disease was proven in 40 pt (21 %). Median follow up was 50 months (1–318) and obtained in 124 pt (64 %). The following events were reported at the last clinic visit: heart failure in =5 pt, syncope in =0 pt, ventricular tachycardia in =7 pt, ICD implantation in 22 pt, and stroke in 22 pt. Death from all causes occurred in 51 of 193 pt (26 %) at a mean age of 72 years (14–78). Kaplan-Meier survival analysis was used to examine survival from all causes of death since first presentation. Observed survival in patients with AHCM was significantly less than expected in an age- and gender matched Minnesota white population (p=0.009). The observed survival at 5, 10 and 15 years was 87 %, 82 %, and 57 % respectively, while the expected survival for these time points was 91 %, 81 %, and 72 %. Conclusions. AHCM in this predominantly North American patient population is associated with an increased mortality. Patients with AHCM have a high incidence of significant cardiovascular symptoms and ventricular arrhythmias. As the disease is less benign than previously suspected, careful longitudinal care by a cardiologist is warranted.
Authors’ reply: Application of Bayesian methods to the inference of phylogeny for enterovirus surveillance
Authors: M Koopmans, H G Niesters, K Benschop, K Wolthers, R Schuurman, S D Pas, E C Claas, A Kroneman, J C Rahamat-Langendoen, H Vennema, H van der Avoort
Journal: Eurosurveillance (2013)

Preview this article: Authors’ reply: Application of Bayesian methods to the inference of phylogeny for enterovirus surveillance, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/18/9/art20410-en-1.gif
Abstract 17461: Prognostic Value of Multidetector Coronary Computed Tomographic Angiography in Patients with Equivocal or Mildly Abnormal Non-Invasive Cardiac Stress Tests
Authors: Clerio F Azevedo, Marcelo Hadlich, Sabrina Bezerra, Joao Petriz, Olga Souza, Alvaro Pontes, Carmo, Plinio, Junior, Carlos Cleverson Pereira, Denilson Albuquerque, Jorge Moll
Journal: Circulation (2010)
Abstract 516: Intermittent Stretch-Induced Formation of Gap Junction Between Fibrocytes and Cardiomyocytes Improves Dyssynchronous Contraction in Circular Engineered Heart Tissue
Authors: Motonori Ando, Rajesh G Katare, Yoshihiko Kakinuma, Fumiyasu Yamasaki, Takayuki Sato
Journal: Circulation (2006)

Background: Three-dimensional engineered heart tissue (EHT) is a potential source for cardiomyoplasty. However, EHT often exhibits dyssynchronous contraction because of a lack of electrical couplin...
Sequential use of sorafenib and sunitinib in renal cancer: Retrospective analysis in 90 patients
Authors: M. P. Sablin, L. Bouaita, C. Balleyguier, J. Gautier, C. Celier, J. L. Balcaceres, S. Oudard, A. Ravaud, S. Négrier, B. Escudier
Journal: Journal of Clinical Oncology (2007)

5038 Background: Sorafenib (So) and sunitinib (Su) have been recently approved for the treatment of advanced renal cell carcinoma (RCC). Following this approval, sequential use of both drugs is often proposed, although very few data are available to support it. Material and Methods: We reviewed all patients (pts) who received sequentially So-Su or Su-So in the last 3 years from 4 sites in France. All pts had been enrolled in clinical studies or in the extended access programs. In all patients demography, prognostic factors (MSKCC score), number of metastatic sites, best response (BR) and PFS with each treatment were recorded. Some patients are still too early for response and PFS assessment under the second treatment. Results: 68 pts first received So while 22 pts received Su first (continuous dosing in 12, intermittent in 10). Results under the first treatments were as follows: median PFS 26.1 wks, mean duration of treatment 33.2 wks; and median PFS was 22 wks, mean duration of treatment 26.9 wks for So and Su respectively. BR in terms of partial response (PR), stable disease (SD), progressive disease (PD) is given in the table . 2 pts stopped So because of toxicity and response is not available (NA), and 22 pts (NE) are too early in the course of the second treatment. Overall, PR rate was 17.6% for So and 22.7% for Su. PR or SD was observed as best response in the second treatment in both sequences. Only 6 pts had PD with both drugs: all of them had 3 or more metastatic sites and were in intermediate or poor MSKCC risk groups. Conversely, 4 pts had PR with both drugs, and were in good (n=2) or intermediate (n=2) risk groups. 11 pts only have died so far. Conclusions: these results suggest the lack of cross resistance between So and Su, and support the sequential use of So and Su in RCC. Updated data will be presented at ASCO. [Table: see text] No significant financial relationships to disclose.
Abstract 4: Resuscitation with Adenocaine and Magnesium Reduces Fluid Requirement and Improves Cardiac Function Following 72% Blood Loss in the Pig
Authors: Asger Granfeldt, Torben Kær Nielsen, Christoffer Sølling, Geoffrey P. Dobson, Lise Wogensen, Jakob Vinten-Johansen, Else Tønnesen
Journal: Circulation (2011)

Introduction: Fluid therapy following severe hemorrhagic shock triggers ischemia-reperfusion (I/R) injury and multi-organ dysfunction. The combination of adenocaine (adenosine and lidocaine), and Mg2+ (ALM) has been shown to stabilize cardiac function and hemodynamics after myocardial I/R. Hypothesis: ALM in 7.5%NaCl at resuscitation: 1) reduces fluid requirements during permissive hypotension and 2) improves post-resuscitation cardiac function. Methods: Pigs (38kg) were randomized to: Sham (n=5), Sham + ALM (n=5), hemorrhage (n=11), and hemorrhage + ALM (n=9). Animals were subjected to pressure controlled hemorrhage at a target MAP of 35mmHg. After 90 min Ringers acetate and 20ml 7.5% NaCl ± ALM (Adenosine 0.23 mg/kg; Lidocaine 0.64 mg/kg; Mg2+ 0.4 mg/kg) was infused to maintain a target MAP of 50 mmHg (permissive hypotension). After 30min 75% of the shed blood was re-infused ± ALM (Adenosine 0.82 mg/kg; Lidocaine 1.66 mg/kg) and the pigs were observed for 6 hrs. Cardiac function was evaluated by pressure-volume (P-V) analysis. Results: In the ALM group 40% less fluid was required to maintain a MAP of 50mmHg for 30min (hemorrhage: 41.5ml/kg CI: 27.7-61.8 vs. ALM: 24.7ml/kg CI:19.4-31.5*). During permissive hypotension 7.5% NaCl ALM significantly increased end-systolic pressure by 27% (hemorrhage: 70 mmHg ± 3 vs. ALM: 89 mmHg ± 9*) and cardiac contractility by 64% (dP/dtmax) (hemorrhage: 2622 mmHg/sec ± 331 vs. ALM: 4301 mmHg/sec ± 262*). Treatment with ALM at blood infusion reduced whole body O2 consumption by 27% lasting 30 min into infusion (group difference p&lt;0.05). In addition, systolic function after blood reinfusion, evaluated by the end-systolic P-V relationship and preload recruitable stroke work, was significantly improved in ALM vs. hemorrhage. Furthermore, ALM enhanced relaxation (dP/dtmin) during reperfusion (hemorrhage: -1578 mmHg/sec ± 103 vs. ALM -2178 mmHg/sec ± 189*). Conclusion: 7.5% NaCl ALM reduced fluid requirements by 40% during permissive hypotension, improved cardiac function and reduced total body O2 consumption following severe hemorrhage. Administration of ALM is effective in minimizing fluid requirements and I/R injury following hemorrhage. (* p&lt;0.05)
Abstract 16946: Induced Pluripotent Stem Cell Derived cKitLowSca1HighFlkHigh Progenitor Cells Undergo Angiomyogenic Differentiation in the Infarcted Heart and Preserve Global Heart Function
Authors: Muhammad Z Afzal, Khawaja H Haider, Rafeeq P Ahmed, Shujia Jiang, Vien K Lai, Muhammad Ashraf
Journal: Circulation (2011)

Background:  We have previously established that induced pluripotent stem (iPS) cells spontaneously differentiate into beating cardiomyocytes. The present study was designed to identify cardiac progenitor cell (PCs) population in iPS cells and determine their cellular and molecular characteristics and myocardial regenerative potential.   Methods and Results:  PCs were sorted from day-5 embryoid bodies (EBs) on flow cytometer. Surface marker analysis showed that PCs were cKit low Sca1 high Flk high  besides positivity for Nkx2.5 and GATA4. When exposed to 1% hypoxia for 24 hours, PCs showed significant increase in gene expression of proangiogenic and cardiomyogenic factors like VEGF, Flt-1, Angiopoietin-1, vWF, and Nkx2.5 as compared to the cells cultured under normoxia. VEGF secretion in the conditioned medium from PCs cultured under hypoxia was 290 pg/ml ( p  vs  cells under normoxia, 126pg/ml) and showed enhanced  in vitro  angiogenic potential as determined by tube formation assay (39.8±1.9,  p  vs  control) and cell invasion assay (220.5±1.8;  p  vs  control) using rat aortic endothelial cells. For  in vivo  determination of cardiogenic potential of PCs, 20µl DMEM without cells (group1, n=6) or containing 5.0x10 5  male cKit low Sca1 high Flk high  PCs labeled with PKH26 and cultured under normoxia (group2, n=8) or 1% hypoxia for 24 hours (group3, n=8) were injected intramyocardially in a female mouse model of acute coronary artery ligation. Real time PCR on day7 for  Sry  gene (n=4/group) showed higher survival in group-3 ( p  vs  group-2). Echocardiography at 4 weeks after cell transplantation, significant improvement in global heart function was observed in group-3 (LVEF =55.9%, LVFS =21%;  p  vs  group-2). Fluorescence immunostaining of the histological sections for myogenic and endothelial cell specific markers showed cardiac differentiation and increased blood vessel density in group-3 at 40x ( p  vs  group-2).   Conclusions:  iPS cell-derived PCs comprise a multipotent precursor population capable of repopulating the infarcted heart to preserve global cardiac function.
Staying true to mission.
Authors: Alan J Gelenberg
Journal: World Psychiatry (2007)

I am probably not the only reader who responded with defensiveness and irritation to the strident tone of Giovanni Fava's commentary. Nevertheless, when my higher cortical functions returned, I found myself in substantial agreement with his concerns. We face a wave of public mistrust that has not yet crested. In truth, ethical breeches have occurred. The integrity of psychiatry and all of medicine requires that we take bold, earnest, prompt steps to remedy this.
Increased expression of the epithelial anion transporter pendrin/SLC26A4 in nasal polyps of patients with chronic rhinosinusitis
Authors: Sudarshan Seshadri, Xiang Lu, Matthew R. Purkey, Tetsuya Homma, Andrew Wonho Choi, Roderick Carter, Lydia Suh, James Norton, Kathleen E. Harris, David B. Conley, Atsushi Kato, Pedro C. Avila, Barbara Czarnocka, Peter A. Kopp, Anju T. Peters, Leslie C. Grammer, Rakesh K. Chandra, Bruce K. Tan, Zheng Liu, Robert C. Kern, Robert P. Schleimer
Journal: Journal of Allergy and Clinical Immunology (2015)
Functional linkage between the S1 site, sodium site, and the calcium site in the protease domain of human activated protein C (APC): Evidence that sodium coordinates to four carbonyl groups from two separate loops of APC.
Authors: S. P. Bajaj, M. C. Underwood, A. E. Schmidt, K. Padmanabhan, W. Bode, T. Mather
Journal: Blood (2001)
Abstract 20896: Anticoagulation does not Prevent Atrial Thrombosis in Fontan Patients with Transvenous Atrial Leads
Authors: Sabrina Tsao, Barbara J Deal, Kendra Ward, Wayne H Franklin
Journal: Circulation (2010)

Introduction:  Chronotropic incompetency associated with atrial arrhythmias in patients with atriopulmonary Fontan repairs poses technical challenges for atrial pacing. Transvenous atrial pacing is an alternative to the extensive surgery needed for epicardial lead placement in single ventricle patients.   Methods:  We reviewed prior pacing strategies in 120 consecutive patients undergoing Fontan conversion (FC) with arrhythmia surgery and pacemaker implantation at Children9s Memorial Hospital between 1994 −2008. All pts had functionally single ventricle, with prior Fontan type surgeries. Prior to FC, 32 pts had previous pacemaker implantation, 10 with transvenous or transmural atrial leads; 22 pts with epicardial atrial leads. Charts were reviewed for vascular complications and clinical evidence of atrial thrombus by echocardiogram, and compared with intraoperative findings at FC.   Results:  Ten pts had prior transvenous (n=9) or transmural (n=1) atrial leads, and adequate anticoagulation was documented in 7/10 pts. Prior ablation procedures were performed before lead placement in 7/10 pts. All pts had preoperative transesophageal echocardiogram; atrial thrombus was detected on one pt who had experienced a prior cerebrovascular accident, resulting in hemiparesis. At the time of FC surgery, massive intra-atrial thrombi were identified in 2 pts; both pts were receiving warfarin for anticoagulation, with documented therapeutic INR. Laminar adherent atrial thrombus was massive in the pt with prior stroke, measuring 9 x 3.9 cm, 1.2 cm in thickness on the atrial lead, with additional intra-cavitary thrombus measuring 5.5 x 4.1 cm, 1 cm in thickness. The second pt had 1.5 x 1.5 cm thrombus on the pacing lead tip. Atrial thrombus was identified in 2/110 pts without intra-atrial leads. P    Conclusions:  Use of transvenous leads should be avoided in atriopulmonary Fontan repairs, due to risk of developing massive thrombi despite chronic warfarin anticoagulation.
DRUG POINTS: Fixed drug eruption with fluconazole
Authors: J M Morgan, A J Carmichael
Journal: BMJ (1994)

A 27 year old man was referred with an 18 month history of a recurrent rash on the extensor surfaces of his elbows. He had suffered 15 episodes, each lasting three days and resolving spontaneously to leave residual bluish-grey macules (1 cm2. The patient had taken minocycline 50 mg daily for three years for acne and occasionally took Migraleve …
Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression
Authors: Lan Wang, Na Man, Xiao-Jian Sun, Yurong Tan, Marta García-Cao, Fan Liu, Megan Hatlen, Haiming Xu, Gang Huang, Meredith Mattlin, Arpit Mehta, Evadnie Rampersaud, Robert Benezra, Stephen D. Nimer
Journal: Blood (2015)
Stopping selegiline may lead to problems for patients
Authors: K E Anderson, A C Girdwood, J A Wilson
Journal: BMJ (1996)

Effect ofadding selegiline to levodopa in early, mild Parkinson's disease Other studies have not shown increased mortality EDrTOR,-AS the manufacturers of selegiline, we were surprised to learn that the study by the Parkinson's Disease Research Group of the United Kingdom suggested increased mortality in patients given combination treatment of levodopa plus selegiline.'No increased mortality has been shown in other controlled studies with the same objectives.We have gathered data from 10 controlled, long term studies (some published, some continuing; in seven the duration of treatment was at least 3-5 years); 963 patients received selegiline alone or with levodopa and 1093 received placebo or other antiparkinsonian drugs.The mortality was 2-8% and 3 3%, respectively (table 1).When only data from the studies of at least 3-5 years' treatment were analysed the mortality was 5-2% for the selegiline group and 5 5% for the control group.No differences in the causes of death between the two groups were found.
CUTANEOUS DIPHTHERIA WITH TOXIC MYOCARDITIS: REPORT OF FATAL CASE WITH NECROPSY FINDINGS
Authors: Saul Solomon, Carl W. Irwin
Journal: Annals of Internal Medicine (1947)

Case Reports1 January 1947CUTANEOUS DIPHTHERIA WITH TOXIC MYOCARDITIS: REPORT OF FATAL CASE WITH NECROPSY FINDINGSSAUL SOLOMON, F.A.C.P., CARL W. IRWINSAUL SOLOMON, F.A.C.P.Search for more papers by this author, CARL W. IRWINSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-1-116 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the surgery of war wounds, one must expect to lose a number of patients whose injuries are extensive. However, when the injury is in itself trivial and a fatal complication results, the outcome is apt to disturb the equanimity of those who have attended the case and to point the moral that there are no trivial war wounds. Every case is potentially serious and the results unpredictable.The case we wish to report is that of a soldier who developed abrasions of the buttocks from riding a mule. These abrasions became infected with Klebs-Loeffler bacilli, and he died of...Bibliography1. Personal Communication to the Author, October 14, 1944. Google Scholar2. CAMERONMUIR JDEG: Cutaneous diphtheria in Palestine, Lancet, 1942, li, 720. CrossrefGoogle Scholar3. HUNT TC: Medical experiences in North Africa, Brit. Med. Jr., 1944, ii, 495. CrossrefGoogle Scholar4. BENSTEAD HJ: A limited outbreak of diphtheria exhibiting both cutaneous and faucial lesions, Bull. Hyg., 1937, xii, 182. Google Scholar5. MELCHIOR E: Wound diphtheria, Bull. War Med., 1941, l, 217. Google Scholar6. MYERS JD: Chronic cutaneous diphtheria, Office of the Chief Surgeon, ETO, Med. Bull., 1944, xix, 27. Google Scholar7. Army Medical Department Bulletin, War Office, London, 1944, No. 36 (June). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 21, 1945. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiphtheriaDie DiphtherieDie Diphtherie 1 January 1947Volume 26, Issue 1Page: 116-120KeywordsDiphtheriaMyocarditisSurgery ePublished: 1 December 2008 Issue Published: 1 January 1947 PDF downloadLoading ...
Pneumomediastinum Following Blunt Trauma
Authors: Christian de Virgilio, Dennis Yong Kim
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal