tbuckley/cabot-search huggingface dataset:
Abstract 2439: Visually-Guided Pulmonary Vein Isolation Using a Balloon Ablation Catheter to Treat Patients with Paroxysmal Atrial Fibrillation: One-Year Clincial Outcome Following a Single Ablation Procedure
Authors: Vivek Y Reddy, Petr Neuzil, Sakis Themistoclakis, Aldo Bonso, Antonio Rossillo, Antonio Raviele, Walid Saliba, Robert Schwiekert, Sabine Ernst, Karl-Heinz Kuck, Jeremy N Ruskin, Andrea Natale
Journal: Circulation (2007)

Introduction: During AF catheter ablation, placing contiguous point ablation lesions to electrically isolate the PVs can be technically challenging. A novel balloon catheter (EAS, Endoscopic Ablation System, Cardiofocus, Inc.) which utilizes an endoscope for real-time visualization of the LA-PV junction and adjustable arcs of ablative light energy was used to isolate the PVs. This report details the one-year follow-up results after a single treatment. Methods: In this three-center study, 30 patients with a history of symptomatic drug-resistant paroxysmal AF were studied: Sex: M/F = 26/4 (87%/13%); Age 53 ± 11 years (28 –73); AF duration: 6.0±4.9 years (range 0.4 –24.1); LA diameter: 4.3±0.5 cm (range 3.1– 4.9); LVEF 67.6±8.9% (range 45– 86). PV isolation using the EAS was confirmed using a circular mapping catheter. There were no exclusion criteria related to PV shape/number. Results: Electrical PV isolation was achieved in 91% (105/116) of the targeted PVs. An average of 14 energy deliveries/PV were delivered (range 2– 40). There was no significant PV stenosis. There were three primary adverse events. Following a 90-day blanking period, 70% (21/30) of patients were free from symptomatic AF episodes &gt;1 min at 6-month follow-up, and 67% (20/30) were free from symptomatic AF episodes lasting &gt;1 minute through one-year follow-up. Two treatment success were on AADs for indications other than AF. An examination of the treatment failures was conducted. There were no differences between chronic treatment successes and failures in sex (p=0.56), age (p=0.22), EF (p=1.0), LA diameter (p=0.70), years of AF (p=0.30) and acute PV isolation of all PVs versus less than all PVs (p=0.66). Most treatment ``failures” did not require repeat AF ablation due to minimal symptoms. One underwent subsequent RF ablation for AF in follow-up; PV reconnections were noted. Conclusions: A single treament with the visually-guided EAS ablation system appears feasible, safe and efficacious to treat patients with paroxysmal AF.
Drug-Eluting Stents in the Treatment of Intermediate Lesions
Authors: Jeffrey W. Moses, Gregg W. Stone, Eugenia Nikolsky, Gary S. Mintz, George Dangas, Eberhard Grube, Stephen G. Ellis, Alexandra J. Lansky, Giora Weisz, Martin Fahy, Yingbo Na, Mary E. Russell, Dennis Donohoe, Martin B. Leon, Roxana Mehran
Journal: Journal of the American College of Cardiology (2006)
Trastuzumab and capecitabine in patients with HER2-expressing metastatic pancreatic cancer: A multicenter phase II study of the German AIO Pancreatic Cancer Group (AIO PK-0204).
Authors: M. Geissler, R. Hofheinz, M. H. Moehler, M. Bitzer, S. H. Boeck, A. Reinacher-Schick, V. Heinemann, J. Harder
Journal: Journal of Clinical Oncology (2010)

4070 Background: In metastatic pancreatic cancer (mPaCa) overexpression of the HER2 receptor has been reported in up to 82% of cases, suggesting its use as a therapeutic target. Therefore, the study was conducted to determine the efficacy and toxicity of capecitabine (CAP) and trastuzumab (TRAS) in pts with mPaCa. Methods: Eligible pts had histologically confirmed mPaCa. The primary endpoint was PFS at 12 weeks. Pts with mPaCa immunohistochemically overexpressing HER2 grade 3 or grade 2 with gene amplification (FISH) received TRAS 4 mg/kg initially followed by weekly 2 mg/kg combined with CAP 1,250 mg/m2 bid day 1-14, q21. The study with planned 37 pts was prematurely closed due to unexpected low HER2 expression. Results: Between May 1994 and February 1998 a total of 212 pts with a median age 64 years (range 38-86) were centrally screened for HER2 expression. In 207 pts the tumor specimens could be assessed for HER2 expression and gene amplification: By IHC 83 (40%) were grade 0, 71 (34%) grade 1, 31 (15%) grade 2, and 22 (11%) grade 3, respectively. One IHC grade 2 and all IHC grade 3 specimens showed gene amplification by FISH. From the 23 pts with HER2 gene amplification 17 could be assessed for response to treatment and toxicity in an intention- to treat analysis. Reported grade 3/4 toxicities in 88 cycles of chemotherapy were: leucopenia 6%, diarrhea 6%, nausea 6%, hand-foot syndrome 6%. There was no TRAS-attributable cardiac toxicity. PFS at 12 weeks was 23,5%, the median OS was 7.0 months. Conclusions: In contrast to previous findings, this multi-center study demonstrated HER2 overexpression and gene amplification in only 11% of pts with mPaCa. This discrepancy can be explained by the use of centrally reviewed standardized HER2 test methods and the examination of a large unselected cohort in the present study. Although the therapy was well tolerated, PFS and OS did not perform favourably compared to standard gemcitabine chemotherapy even if considering the exclusion of locally advanced PaCa in this cohort. Due to the low HER2 overexpression found in this study we do not recommend further evaluation of anti-HER2 treatment in pts with mPaCa. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Roche
Athens, athletes, and arrhythmias: The cardiologist's dilemma⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Kyoko Soejima, William G. Stevenson
Journal: Journal of the American College of Cardiology (2004)
Abstract 2286: Pseudonormalization Tendency of the Tei Index at High Filling Pressures -A Serious Limitation for its Use as a Myocardial Performance Index
Authors: Michael Dandel, Hans Lehmkuhl, Dagmar Kemper, Roland Hetzer
Journal: Circulation (2007)

Background: The potential advantage provided by the combination of systolic and diastolic parameters makes the Tei index (myocardial performance index) attractive. This index is prolonged during mild or moderate left ventricular (LV) systolic dysfunction. The influence of diastolic dysfunction is unclear. We assessed the reliability of the Tei index for the evaluation of LV dysfunction, in relation to the severity of systolic and/or diastolic impairment. Methods: To evaluate the systolic LV dysfunction associated with various degrees of diastolic dysfunction by the Tei index, the isovolumetric contraction and relaxation time (IVCT and IVRT) and the ejection time were measured by continuous wave Doppler in 155 consecutive patients accepted for heart transplantation (HTx) because of advanced dilated cardiomyopathy (DCM). To evaluate the diastolic dysfunction by the Tei index, the same Doppler measurements were performed in 200 HTx patients who showed isolated diastolic LV dysfunction with normal ejection fraction (LVEF ≥ 55%). Results: Although the Tei index was prolonged (0.67 ±0.16) in DCM patients, there was no correlation between LVEF and Tei index. The Tei index was even lower in NYHA IV in comparison to NYHA II–III patients (0.56 ±0.11 vs. 0.76 ±0.14; p &lt;0.001)). The LVEF was 17.5 ±5% in NYHA IV and 27.2 ±6% in NYHA II–III patients (p &lt;0.01). The IVRT was shorter (p&lt;0.001) in NYHA IV (60.8 ±13 ms) than in NYHA II–III patients (113.9 ±19.5 ms). After HTx, due to initially prolonged IVRT, the Tei index was higher before than after the 1 st post-HTx year (0.54 ±0.08 vs. 0.45 ±0.08; p&lt;0.01). The Tei index was also lower (p&lt;0.05) in patients with coronary allograft vasculopathy (CAV), than in those without (0.42 ±0.10 vs. 0.48 ±0.09). For both DCM and HTx patients there was a correlation between IVRT and Tei index (p &lt;0.001; r = 0.71 and r =0.72, respectively) and also between LV enddiastolic pressure and Tei index (p &lt;0.001; r = −0.69 and r = −0.74, respectively). Conclusions: The shortening of the IVRT due to the elevation of filling pressures in both severe systolic dysfunction (i.e. advanced DCM) and isolated diastolic dysfunction (post-HTx CAV) lowers the Tei index (pseudo-normalization tendency) and thus, in these clinical situations, the Tei index becomes misleading.
The phototherapy light visor: more to it than meets the eye
Authors: M H Teicher, C A Glod, D A Oren, P J Schwartz, C Luetke, C Brown, N E Rosenthal
Journal: American Journal of Psychiatry (1995)

The purpose of the study was to ascertain whether phototherapy light visors provide an effective treatment for seasonal affective disorder. Previous studies have demonstrated a moderate response rate but have failed to find any difference in efficacy between light intensities.Subjects were randomly assigned to receive, over a 2-week treatment period, 30 minutes of morning phototherapy with a light visor that emitted either a dim (30-lux) red light or a bright (600-lux) white light. Raters were blind to treatment, and patients were unaware of the alternatives. Response was assessed by using the structured 21-item Hamilton Depression Rating Scale, with an eight-item addendum for atypical depressive symptoms. Fifty-seven patients were enrolled across two sites.Patients assigned to the different visors had similar baseline depression scores and similar expectations of outcome. Hamilton depression scale scores declined by 34.6% for subjects given bright white light and by 40.9% for subjects given dim red light. Scores for atypical depressive symptoms fell by 44.1% for patients assigned the bright white light visors and by 49.0% for patients assigned the dim red light visors. Altogether, 39.3% of the patients who received red light and 41.4% of the patients who received bright white light showed a full clinical response.There were no significant differences in therapeutic response between patients who were treated with red or white light. The results of this study suggest that the phototherapy light visor may function as an elaborate placebo. Alternative explanations, however, are considered.
Abstract 15141: Diffuse Calcium Deposits in Aortic Valve as a Marker of the Extent and Vulnerable Characteristics of Coronary Artery Plaque Assessed by 64-Multidetector Computed Tomography
Authors: Hiroto Utsunomiya, Hideya Yamamoto, Eiji Kunita, Ryo Yamazato, Yoji Urabe, Hiroshi Tsushima, Ken Ishibashi, Takayuki Hidaka, Noboru Oda, Yoshihiro Dohi, Kenji Nishioka, Satoshi Kurisu, Yukiko Nakano, Takafumi Ishida, Yasuki Kihara
Journal: Circulation (2011)

Background: Aortic valve calcification (AVC) is considered a manifestation of atherosclerosis. However, the impact of diffuse calcium deposits in aortic valve on coronary atherosclerosis is unknown...
Abstract 9816: Use of the Wearable Cardioverter Defibrillator and Survival After Coronary Artery Revascularization in Patients with Left Ventricular Dysfunction
Authors: Edwin T Zishiri, Edmond Cronin, Sarah Williams, Eugene Blackstone, Steven Ellis, Nicholas Smedira, Marc A Gillinov, Gonzalez-Stawinski G, Johnston Douglas, Eric Roselli, Jo Ann Glad, Steven J Szymkiewicz, Bruce D Lindsay, Mina K Chung
Journal: Circulation (2011)

Background: ICD implantation for primary prevention of sudden cardiac death (SCD) is typically deferred in the immediate post revascularization period due to reimbursement restrictions, but mortality risk may be highest early after cardiac procedures. The wearable cardioverter-defibrillator (WCD) is a noninvasive device capable of protection from SCD and may be useful during this period. Objective: To determine if there is a difference in survival of patients with LVEF≤35% from a national registry using a WCD after revascularization compared to patients with LVEF≤35% discharged after surgical or percutaneous revascularization without the WCD. Methods: Kaplan-Meier survival, Cox proportional hazards and propensity score matched analyses were performed to determine if survival differed in patients discharged after surgical (CABG) or percutaneous (PCI) coronary revascularization with LVEF≤35% from a national database of WCD users (N=809) compared to patients with LVEF≤35% from surgical and interventional registries at the Cleveland Clinic (N=4149). Results: Survival curves showed higher early compared to late mortality in the non-WCD groups with 90-day mortality after CABG of 3% in WCD users vs. 7% in non-users and after PCI 2% in WCD users vs. 10% in the non WCD users. WCD use was associated with an adjusted 57% lower risk of death (p&lt;0.0001) among post-PCI patients over a mean follow up of 3.1±2.3 years and an adjusted 38% lower risk of death in post CABG patients (p value 0.048) over a mean follow up of mean follow-up 3.2 ± 2.5 years. Limitations: Adjustment for co-morbidities was limited in this single center vs. national database study. Conclusions: In patients with LVEF &lt;35%, WCD users did not demonstrate the high early phase mortality after revascularization that was seen in the non-WCD users. These findings provide a rationale for additional studies of WCD use after revascularization in patients with LV dysfunction.
Cardiopulmonary resuscitation in adults
Authors: A. S Lockey, J. P Nolan
Journal: BMJ (2001)

The United Kingdom's guidelines on advanced life support for adults were updated in 1997 and endorsed by the European Resuscitation Council in 1998.1 During 1999 and 2000 the American Heart Association hosted three meetings of international organisations in Dallas to evaluate the evidence on resuscitation. The sets of guidelines that resulted from the international consensus document have a stronger evidence base than their predecessors but have retained their simplicity. 2 3

Experts at the Dallas meetings included representatives from the American Heart Association, the European Resuscitation Council, the Heart and Stroke Foundation of Canada, the Australian Resuscitation Council, the New Zealand Resuscitation Council, the Resuscitation Council of Southern Africa, the Latin American Resuscitation Council, and Japan. All aspects of resuscitation were reviewed, and the quality of the evidence supporting each resuscitation intervention was appraised. 2 3 The European Resuscitation Council has accepted most of the recommendations from the international consensus document, and its revised guidelines for adults have been summarised in three papers.4–6 The Resuscitation Council (UK) has adopted …
Atherosclerotic and Thrombogenic Neointima Formed Over Sirolimus Drug-Eluting Stent
Authors: Tomoaki Higo, Yasunori Ueda, Jota Oyabu, Katsuki Okada, Mayu Nishio, Akio Hirata, Kazunori Kashiwase, Nobuyuki Ogasawara, Shinichi Hirotani, Kazuhisa Kodama
Journal: JACC. Cardiovascular imaging (2009)
Abstract 15891: Effects of Cardiac Nerve Growth Factor Overexpression on Bone Marrow and Peripheral Blood Progenitor Cells after Myocardial Infarction
Authors: Marco Meloni, Daniela Cesselli, Orazio Fortunato, Andrea Caporali, Elisa Avolio, Elisa Cangiano, Caterina Cavazza, Gaia Spinetti, Paolo Madeddu, Antonio Paolo Beltrami, Costanza Emanueli
Journal: Circulation (2010)

Progenitor cells (PCs) mobilization from the bone marrow (BM) requires many complex signals, including activation of osteoclasts and release of proteolytic enzymes that detach PCs from the endostea...
Incidence of Adverse Events and Negligence in Hospitalized Patients
Authors: Troyen A. Brennan, Lucian L. Leape, Nan M. Laird, Liesi Hebert, A. Russell Localio, Ann G. Lawthers, Joseph P. Newhouse, Paul C. Weiler, Howard H. Hiatt
Journal: New England Journal of Medicine (1991)

As part of an interdisciplinary study of medical injury and malpractice litigation, we estimated the incidence of adverse events, defined as injuries caused by medical management, and of the subgroup of such injuries that resulted from negligent or substandard care.
Norovirus outbreaks linked to oyster consumption in the United Kingdom, Norway, France, Sweden and Denmark, 2010
Authors: T Westrell, V Dusch, S Ethelberg, J Harris, M Hjertqvist, N Jourdan-da Silva, A Koller, A Lenglet, M Lisby, L Vold
Journal: Eurosurveillance (2010)

This paper reports on several simultaneous outbreaks of norovirus infection linked to the consumption of raw oysters. Since January 2010, 334 cases in 65 clusters were reported from five European countries: the United Kingdom, Norway, France, Sweden and Denmark. The article describes the available epidemiological and microbiological evidence of these outbreaks.
Abstract 815: Recovery of Heart Function in Women with Severe Heart Failure from Peripartum Cardiomyopathy in Haiti
Authors: James D Fett, Herriot Sannon, Emmeline Thélisma, Therese L Sprunger, Venkita Suresh
Journal: Circulation (2008)

Peripartum cardiomyopathy (PPCM) is a form of heart failure from dilated cardiomyopathy with one of the greatest potentials for eventual full systolic function recovery. Traditional concepts of PPCM have held that if recovery did not occur by the six-month post-diagnosis mark, it would be unlikely to happen. This report shows that improvement and eventual full recovery may occur long after that initial period. PPCM patients have been identified from the Hôpital Albert Schweitzer PPCM Registry, Deschapelles, Haiti, from 2000 to 2008. All patients fully met diagnostic criteria for PPCM, which include onset of heart failure during the last month of pregnancy up to 5 months postpartum, absence of previous heart disease or other cause of heart failure, and echocardiographic criteria for systolic dysfunction. Recovery was defined as left ventricular (LV) ejection fraction (EF) greater than 50 percent. Echocardiography was carried out at initial diagnosis and at 6-month intervals, with a minimum of 24 months follow-up required for inclusion. Standard treatment included diuretics (lasix) and ACE-inhibitors (captopril), as determined by economic factors, which also excluded the routine use of beta-blockade. Thirty-two out of 116 (27.6 %) PPCM patients fully recovered LV systolic function. Mean follow-up was 35 months. The shortest time to recovery was 3 months and the longest time to recovery was 48 months. The number and cumulative percentage of recovery is shown in the following table : Table: Length of time required for recovery of left ventricular function in 32 Haitian PPCM patients, 2000–2008: Likelihood of recovery did not correlate with age (17–47 years), parity (1–10) or LV EF at diagnosis (12 to 40 %). Complete recovery of LV systolic function in PPCM often occurs after the first 6 to 12 months following diagnosis. It is important to continue treatment and follow-up sufficiently long to assure and document maximum benefit
Abstract 2302: Prediction of Sudden Death in Patients With Chronic Heart Failure: A Prospective Comparative Study of Cardiac I-123 Metaiodobenzylguanidine Imaging and Signal-Averaged Electrocardiogram
Authors: Shunsuke Tamaki, Takahisa Yamada, Takanao Mine, Takashi Morita, Yasumasa Tsukamoto, Masaharu Masuda, Keiji Okuda, Yusuke Iwasaki, Masatake Fukunami
Journal: Circulation (2006)

Background: The identification of patients at risk for sudden death in patients with chronic heart failure (CHF) still remains an important goal. Cardiac I-123 metaiodobenzylguanidine (MIBG) imagin...
Free and Total Vitamin B12 in Cerebrospinal Fluid
Authors: H M KIDD, C E GOULD, J W THOMAS
Journal: JAMA (1963)

Free and total vitamin B(12) levels in serum and cerebrospinal fluid (CSF) were bioassayed, since there were no available data on the relationship between free and total vitamin B(12) in CSF or between free vitamin in serum and CSF vitamin B(12). The subjects were 43 neurological patients. Serum levels were normal in 40 of 43 patients. Values for free and total vitamin B(12) in CSF were the same in 42 of 43 patients. Mean CSF vitamin B(12) was 21 mumug./ml. In 17 cases CSF vitamin B(12) equalled free vitamin B(12) level in serum, in 16 cases CSF vitamin B(12) was lower than the free level in serum, and in 10 cases CSF vitamin B(12) was higher than the free vitamin level in serum. There was no apparent diagnostic correlation. The findings suggest that vitamin B(12) is not bound in CSF and that there is some selective control of passage of vitamin B(12) across the blood-CSF barrier.
Risk Communication and Public Health.
Authors: John C Licciardone
Journal: BMJ (2000)

Eds Peter Bennett, Kenneth Calman 

Oxford University Press, £49.50, pp 272

ISBN 0 19 263037 7

Rating: ![Graphic][1]  ![Graphic][2] 

An emerging disease affects 2% of the population, and treatment is effective only if the disease is caught early. Once symptoms occur treatment is no longer effective, and patients experience a slow painful death. A good screening test exists, with sensitivity approaching 100% and specificity of 90%. What is the probability of having the disease if someone tests positive on the screening test?

Students of public health medicine may recognise this scenario as the classic example of positive predictive value. Bayesian analysis …

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Acyclovir and post-herpetic neuralgia
Authors: M W Mckendrick, M J Wood
Journal: BMJ (1995)

Relation between various factors and response to mammographic screening 1991-2 Did not respond Responded Characteristic (n=34) (n=217) Age range (average) (years) 52-65 (57) 50-65 (57) Non-response for cervical screening 20** 16** Not known personally to general practitioner 22* 77* Marital status: Married 24 176 Widowed 5 29 Divorced 4 5 Single 1 7 *P=0*01, **P=0 001.ascertained whether the following factors were associated with non-attendance: non-response for cervical screening, marital status, and whether the patient had personal knowledge of the general practitioner.The only factors that reached signifi- cance (table) were non-attendance for cervical screening (P< 0 001) and no personal knowledge of the general practitioner (P < 001)).
Abstract 17769: Increased Blood Pressure Variability During Early Bereavement
Authors: Anastasia S Mihailidou, Tom Buckley, Sharon McKinley, Christopher Ward, Roger Bartrop, Marie-Christine Morel-Kopp, Monica Spinaze, Geoffrey Tofler
Journal: Circulation (2011)

Background: Bereavement is a unique stress with heightened cardiovascular disease (CVD) risk for the surviving spouse; the physiological changes underlying this increased risk have not been well defined. Aims: Since increased blood pressure variability (BPV) has been associated with higher CVD mortality, we tested the hypothesis that there is greater BPV during bereavement. Methods: Sixty-three bereaved (B) spouses and parents (41F/22M; aged 65 ± 2 yrs) were studied within 2 weeks of bereavement (acute) and at 6 months (6m), and compared to a non-bereaved (NB) reference group of 78 spouses of discharged patients (52F/26M; age 64 ± 1 yrs) underwent 24-hour ambulatory blood pressure (ABP) assessment using the validated TM-2430 device. Systolic BPV for the awake period (0800 - 2000 hours) was calculated as standard deviation (SD), coefficient of variability (CoV) and average real variability (ARV). SD identifies the spread of BP measurements around a single value (the mean) not accounting for order of measurement, whereas ARV averages absolute differences of consecutive measurements. Results: Acutely bereaved have significantly higher awake systolic blood pressure (SBP, 136 ± 2 vs 131 ± 1 mmHg, p&lt;0.05) and systolic BPV measures (SD and ARV) compared with non-bereaved (see Table 1). By 6 months, there were no longer significant differences between B and NB in ARV or SBP. However, BPV measured by SD remained higher in bereaved at 6 months. Conclusion: This study, the first to focus on CVD risk in early bereavement, demonstrates increased blood pressure variability that may contribute to the increased CVD events. Table 1