tbuckley/cabot-search huggingface dataset:
NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis
Authors: Di Liu, Yu Kuang, Simin Chen, Ruiru Li, Fan Su, Shuoyang Zhang, Qian Qiu, Shuibin Lin, Chuyu Shen, Yingli Liu, Liuqin Liang, Jingnan Wang, Hanshi Xu, Youjun Xiao
Journal: Annals of the Rheumatic Diseases (2024)

Recent studies indicate that N-acetyltransferase 10 (NAT10)-mediated ac4C modification plays unique roles in tumour metastasis and immune infiltration. This study aimed to uncover the role of NAT10-mediated ac4C in fibroblast-like synoviocytes (FLSs) functions and synovial immune cell infiltration in rheumatoid arthritis (RA).
Identifying the association between serum urate levels and gout flares in patients taking urate-lowering therapy: a post hoc cohort analysis of the CARES trial with consideration of dropout
Authors: Sara K Tedeschi, Keigo Hayashi, Yuqing Zhang, Hyon Choi, Daniel H Solomon
Journal: Annals of the Rheumatic Diseases (2024)

To investigate gout flare rates based on repeated serum urate (SU) measurements in a randomised controlled trial of urate-lowering therapy (ULT), accounting for dropout and death.
Electrospun composite-coated endotracheal tubes with controlled siRNA and drug delivery to lubricate and minimize upper airway injury
Authors: Solaleh Miar, Gabriela Gonzales, Gregory Dion, Joo L. Ong, Ronit Malka, Rena Bizios, Ryan C. Branski, Teja Guda
Journal: Biomaterials (2024)

Endotracheal Tubes (ETTs) maintain and secure a patent airway; however, prolonged intubation often results in unintended injury to the mucosal epithelium and inflammatory sequelae which complicate recovery. ETT design and materials used have yet to adapt to address intubation associated complications. In this study, a composite coating of electrospun polycaprolactone (PCL) fibers embedded in a four-arm polyethylene glycol acrylate matrix (4APEGA) is developed to transform the ETT from a mechanical device to a dual-purpose device capable of delivering multiple therapeutics while preserving coating integrity. Further, the composite coating system (PCL-4APEGA) is capable of sustained delivery of dexamethasone from the PCL phase and small interfering RNA (siRNA) containing polyplexes from the 4APEGA phase. The siRNA is released rapidly and targets smad3 for immediate reduction in pro-fibrotic transforming growth factor-beta 1 (TGFϐ1) signaling in the upper airway mucosa as well as suppressing long-term sequelae in inflammation from prolonged intubation. A bioreactor was used to study mucosal adhesion to the composite PCL-4APEGA coated ETTs and investigate continued mucus secretory function in ex vivo epithelial samples. The addition of the 4APEGA coating and siRNA delivery to the dexamethasone delivery was then evaluated in a swine model of intubation injury and observed to restore mechanical function of the vocal folds and maintain epithelial thickness when observed over 14 days of intubation. This study demonstrated that increase in surface lubrication paired with surface stiffness reduction significantly decreased fibrotic behavior while reducing epithelial adhesion and abrasion.
Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma
Authors: Meijie Tian, Jun S. Wei, Nityashree Shivaprasad, Steven L. Highfill, Berkley E. Gryder, David Milewski, G. Tom Brown, Larry Moses, Hannah Song, Jerry T. Wu, Peter Azorsa, Jeetendra Kumar, Dina Schneider, Hsien-Chao Chou, Young K. Song, Abdelrahman Rahmy, Katherine E. Masih, Yong Yean Kim, Brian Belyea, Corinne M. Linardic, Boro Dropulic, Peter M. Sullivan, Poul H. Sorensen, Dimiter S. Dimitrov, John M. Maris, Crystal L. Mackall, Rimas J. Orentas, Adam T. Cheuk, Javed Khan
Journal: Cell Reports Medicine (2024)
ChatGPT4 Outperforms Endoscopists for Determination of Postcolonoscopy Rescreening and Surveillance Recommendations
Authors: Patrick W. Chang, Maziar M. Amini, Rio O. Davis, Denis D. Nguyen, Jennifer L. Dodge, Helen Lee, Sarah Sheibani, Jennifer Phan, James L. Buxbaum, Ara B. Sahakian
Journal: Clinical Gastroenterology and Hepatology (2024)
High Prevalence and Clinical Relevance of Intrapulmonary Vascular Dilatations in Patients Undergoing TIPS Implantation
Authors: Jim B. Mauz, Hannah Rieland, Dominik Berliner, Anja Tiede, Lena Stockhoff, Jan B. Hinrichs, Heiner Wedemeyer, Bernhard C. Meyer, Karen M. Olsson, Benjamin Maasoumy, Tammo L. Tergast
Journal: Clinical Gastroenterology and Hepatology (2024)

Considerate patient selection is vital to ensure the best possible outcomes after transjugular intrahepatic portosystemic shunt (TIPS) insertion. However, data regarding the impact of intrapulmonary vascular dilatations (IPVDs) or hepatopulmonary syndrome (HPS) on the clinical course after TIPS implantation is lacking. Hence, this study aimed to investigate the relevance of IPVD and HPS in patients undergoing TIPS implantation.
Early-onset Colorectal Cancer Patients Do Not Require Shorter Intervals for Post-surgical Surveillance Colonoscopy
Authors: Robin B. Mendelsohn, Anne I. Hahn, Randze Lerie Palmaira, Asha R. Saxena, Pavan Kedar Mukthinuthalapati, Mark A. Schattner, Arnold J. Markowitz, Emmy Ludwig, Pari Shah, Delia Calo, Hans Gerdes, Rona Yaeger, Zsofia Stadler, Ann G. Zauber, Andrea Cercek
Journal: Clinical Gastroenterology and Hepatology (2024)
Longitudinal peanut and Ara h 2 <scp>specific‐IgE</scp>, ‐<scp>IgG<sub>4</sub></scp>, and ‐<scp>IgG<sub>4</sub></scp>/‐<scp>IgE</scp> ratios are associated with the natural resolution of peanut allergy in childhood
Authors: Kayla M. Parker, Thanh D. Dang, Rushani Wijesuriya, Victoria X. Soriano, Adrian J. Lowe, Shyamali C. Dharmage, Paxton Loke, Mimi L. K. Tang, Katie J. Allen, Jennifer J. Koplin, Kirsten P. Perrett, Rachel L. Peters
Journal: Allergy (2024)

Abstract Background There are no studies of longitudinal immunoglobulin measurements in a population‐based cohort alongside challenge‐confirmed peanut allergy outcomes. Little is known about biomarkers for identifying naturally resolving peanut allergy during childhood. Objectives To measure longitudinal trends in whole peanut and component Ara h 2 sIgE and sIgG 4 in the first 10 years of life, in a population cohort of children with challenge‐confirmed peanut allergy, and to determine whether peanut‐specific immunoglobulin levels or trends are associated with peanut allergy persistence or resolution by 10 years of age. Methods One‐year‐old infants with challenge‐confirmed peanut allergy ( n = 156) from the HealthNuts study ( n = 5276) were prospectively followed at ages 4, 6, and 10 years with questionnaires, skin prick tests, oral food challenges, and plasma total‐IgE, sIgE and sIgG 4 to peanut and Ara h 2. Results Peanut allergy resolved in 33.9% (95% CI = 25.3%, 43.3%) of children by 10 years old with most resolving (97.4%, 95% CI = 86.5%, 99.9%) by 6 years old. Decreasing Ara h 2 sIgE ( p = .01) and increasing peanut sIgG 4 ( p &lt; .001), Ara h 2 sIgG 4 ( p = .01), peanut sIgG 4 /sIgE ( p &lt; .001) and Ara h 2 sIgG 4 /sIgE ( p &lt; .001) from 1 to 10 years of age were associated with peanut allergy resolution. Peanut sIgE measured at 1 year old had the greatest prognostic value (AUC = 0.75 [95% CI = 0.66, 0.82]); however, no single threshold produced both high sensitivity and specificity. Conclusion One third of infant peanut allergy resolved by 10 years of age. Decreasing sIgE and sIgG 4 to peanut and Ara h 2 over time were associated with natural resolution of peanut allergy. However, biomarker levels at diagnosis were not strongly associated with the natural history of peanut allergy.
PNPLA3, Obesity, and Heavy Alcohol Use in Cirrhosis Patients May Exert a Synergistic Increase Hepatocellular Carcinoma Risk
Authors: Aaron P. Thrift, Fasiha Kanwal, Hyeyeun Lim, Hao Duong, Yanhong Liu, Amit G. Singal, Saira Khaderi, Sumeet K. Asrani, Christopher I. Amos, Hashem B. El-Serag
Journal: Clinical Gastroenterology and Hepatology (2024)
All FODMAPs Aren’t Created Equal: Results of a Randomized Reintroduction Trial in Patients With Irritable Bowel Syndrome
Authors: Shanti Eswaran, Kara J. Jencks, Prashant Singh, Samara Rifkin, Theresa Han-Markey, William D. Chey
Journal: Clinical Gastroenterology and Hepatology (2024)
Breastfeeding Duration Is Not Associated With Offspring Inflammatory Bowel Disease Risk in Three Population-Based Birth Cohorts
Authors: Manasi Agrawal, Ketil Størdal, Anne Vinkel Hansen, Malin Östensson, Maiara Brusco De Freitas, Kristine H. Allin, Tine Jess, Johnny Ludvigsson, Karl Mårild
Journal: Clinical Gastroenterology and Hepatology (2024)

Breastfeeding is critical for offspring health and development. Although many observational studies report a protective effect between breastfeeding and inflammatory bowel disease (IBD), the relationship is not well-understood.
Long-term Outcome of Risankizumab in Crohn’s Disease: a Real-world GETAID Study
Authors: Mathurin Fumery, Benedicte Caron, Xavier Hébuterne, Romain Altwegg, Xavier Roblin, Carmen Stefanescu, Antoine Meyer, Maria Nachury, David Laharie, Catherine Le Berre, Lucas Guillo, Amélie Biron, Ludovic Caillo, Anthony Buisson, Stephane Nancey, Mathieu Uzzan, Lucine Vuitton, Cyrielle Gilletta, Sophie Geyl, Antoine Blain, Julien Kirchgesner, Philippe Ah-Soune, Nicolas Duveau, Mathias Vidon, Vered Abitbol, Thierry Paupard, My-Linh Tran-Minh, Antoine Defrance, Laurent Peyrin-Biroulet
Journal: Clinical Gastroenterology and Hepatology (2024)
Evidence and choice: The BCLC vision for tailoring clinical decision-making
Authors: Maria Reig, Alejandro Forner, Jordi Rimola, Joana Ferrer-Fàbrega, Marta Burrel, Ángeles Garcia-Criado, Robin K. Kelley, Peter R. Galle, Vincenzo Mazzaferro, Riad Salem, Bruno Sangro, Amit G. Singal, Arndt Vogel, Josep Fuster, Carmen Ayuso, Jordi Bruix
Journal: Journal of Hepatology (2024)
Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect
Authors: Tamara Kögl, Hsin-Fang Chang, Julian Staniek, Samuel C.C. Chiang, Gudrun Thoulass, Jessica Lao, Kristoffer Weißert, Viviane Dettmer-Monaco, Kerstin Geiger, Paul T. Manna, Vivien Beziat, Mana Momenilandi, Szu-Min Tu, Selina J. Keppler, Varsha Pattu, Philipp Wolf, Laurence Kupferschmid, Stefan Tholen, Laura E. Covill, Karolina Ebert, Tobias Straub, Miriam Groß, Ruth Gather, Helena Engel, Ulrich Salzer, Christoph Schell, Sarah Maier, Kai Lehmberg, Tatjana I. Cornu, Hanspeter Pircher, Mohammad Shahrooei, Nima Parvaneh, Roland Elling, Marta Rizzi, Yenan T. Bryceson, Stephan Ehl, Peter Aichele, Sandra Ammann
Journal: The Journal of Experimental Medicine (2024)

SYNTAXIN-11 (STX11) is a SNARE protein that mediates the fusion of cytotoxic granules with the plasma membrane at the immunological synapses of CD8 T or NK cells. Autosomal recessive inheritance of deleterious STX11 variants impairs cytotoxic granule exocytosis, causing familial hemophagocytic lymphohistiocytosis type 4 (FHL-4). In several FHL-4 patients, we also observed hypogammaglobulinemia, elevated frequencies of naive B cells, and increased double-negative DN2:DN1 B cell ratios, indicating a hitherto unrecognized role of STX11 in humoral immunity. Detailed analysis of Stx11-deficient mice revealed impaired CD4 T cell help for B cells, associated with disrupted germinal center formation, reduced isotype class switching, and low antibody avidity. Mechanistically, Stx11−/− CD4 T cells exhibit impaired membrane fusion leading to reduced CD107a and CD40L surface mobilization and diminished IL-2 and IL-10 secretion. Our findings highlight a critical role of STX11 in SNARE-mediated membrane trafficking and vesicle exocytosis in CD4 T cells, important for successful CD4 T cell–B cell interactions. Deficiency in STX11 impairs CD4 T cell–dependent B cell differentiation and humoral responses.
From gut to lung and back again: early life microbiota in cystic fibrosis
Authors: Lindsay J. Caverly, Benjamin D. Ross, Robert P. Dickson
Journal: European Respiratory Journal (2024)

The connection between gastrointestinal and respiratory pathology in cystic fibrosis (CF) was first observed in 1938 in Dorothy Andersen's initial description of CF [1]. Andersen reported on the autopsy findings of 49 infants and young children with CF, which notably included near-universal evidence of pancreatic fibrosis, nutritional deficiencies and chronic respiratory infections. In the following decades, dramatic increases in life expectancy for people with CF largely resulted from therapies directed towards gastrointestinal and respiratory disease, including pancreatic enzymes, calorie and vitamin supplementation, and antibiotics. Multiple observational studies have demonstrated links between nutrition and respiratory outcomes, particularly in the first years of life. For example, higher weight- and height-for-age in infancy and toddlerhood has been associated with improved respiratory outcomes in later childhood and adolescence, including better lung function and lower rates of respiratory infection with Pseudomonas aeruginosa [2, 3]. An unprecedented study of the gut, lungs and blood in children with cystic fibrosis <https://bit.ly/3IYsmXv>
Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury
Authors: Jamil Nehme, Lina Mesilmany, Marta Varela-Eirin, Simone Brandenburg, Abdullah Altulea, Yao Lin, Mariana Gaya da Costa, Marc Seelen, Jan-Luuk Hillebrands, Harry van Goor, Raya Saab, Haidar Akl, Natacha Prevarskaya, Valerio Farfariello, Marco Demaria
Journal: Nature Aging (2024)
Injectable Thermosensitive Gel CH‐BPNs‐NBP for Effective Periodontitis Treatment through ROS‐Scavenging and Jaw Vascular Unit Protection
Authors: Yuli Wang, Yuqing Yuan, Ruyu Wang, Tianxiao Wang, Fanyi Guo, Yifeng Bian, Tianyao Wang, Qian Ma, Hua Yuan, Yifei Du, Jianliang Jin, Huijun Jiang, Feng Han, Jiandong Jiang, Yongchu Pan, Lulu Wang, Fan Wu
Journal: Advanced Healthcare Materials (2024)

Periodontitis, a prevalent inflammatory condition in the oral cavity, is closely associated with oxidative stress-induced tissue damage mediated by excessive reactive oxygen species (ROS) production. The jaw vascular unit (JVU), encompassing both vascular and lymphatic vessels, plays a crucial role in maintaining tissue fluid homeostasis and contributes to the pathological process in inflammatory diseases of the jaw. This study presents a novel approach for treating periodontitis through the development of an injectable thermosensitive gel (CH-BPNs-NBP). The gel formulation incorporates black phosphorus nanosheets (BPNs), which are notable for their ROS-scavenging properties, and dl-3-n-butylphthalide (NBP), a vasodilator that promotes lymphatic vessel function within the JVU. These results demonstrate that the designed thermosensitive gel serve as a controlled release system, delivering BPNs and NBP to the site of inflammation. CH-BPNs-NBP not only protects macrophages and human lymphatic endothelial cells from ROS attack but also promotes M2 polarization and lymphatic function. In in vivo studies, this work observes a significant reduction in inflammation and tissue damage, accompanied by a notable promotion of alveolar bone regeneration. This research introduces a promising therapeutic strategy for periodontitis, leveraging the unique properties of BPNs and NBP within an injectable thermosensitive gel.
Disappearance of “Elongated Pony Tail Sign” Following Chemoradiotherapy in a Case of Primary Cerebellopontine Angle Ependymoma With Spinal Drop Metastasis: 18F-FDG PET/CT Scan Findings
Authors: Sarin Krishna, Abhiram G. Ashwathanaryana, Rakesh Kumar Mishra, Shubham Asrani, Vinita Dewangan
Journal: Clinical Nuclear Medicine (2024)

Ependymomas are rare glial tumors that commonly arise from the lining cells of ventricular system and constitute ~10% of intracranial pediatric malignancies. The incidence of ependymoma in adults is rare. Due to close approximation with the ventricular system, subtentorial ependymomas are more prone to show cerebrospinal fluid metastasis compared with supratentorial ependymomas. We present a case of subtentorial cerebellopontine angle ependymoma with diffuse spinal drop metastases showing "elongated pony tail appearance" in a 69-year-old man with complete metabolic response on 18 F-FDG PET/CT imaging following chemoradiotherapy.
VP3-2024: A randomized study of 6 vs 3 years of adjuvant imatinib in patients with localized GIST at high risk of relapse
Authors: A. Le Cesne, C. Schiffler, O. Bouche, M. Brahmi, F. Duffaud, M. Toulmonde, B. Landi, W. Lahlou, D. Pannier, E. Bompas, F. Bertucci, L. Chaigneau, O. Collard, M. Pracht, A. Adenis, I. Ray-Coquard, S. Metzger, S. Chabaud, D. Perol, J-Y. Blay
Journal: Annals of Oncology (2024)
FDG PET/CT Findings of Primary Pulmonary Choriocarcinoma in a Postmenopausal Woman
Authors: Jun Zhang, Aisheng Dong, Yang Wang
Journal: Clinical Nuclear Medicine (2024)

Choriocarcinomas usually occur in the genital tracts of reproductive-age women after a gestational event. Primary pulmonary choriocarcinoma is very rare. We describe FDG PET/CT findings of primary pulmonary choriocarcinoma with multiple intrapulmonary metastases in a postmenopausal woman with elevated serum beta human chorionic gonadotropin level. On FDG PET/CT, the large primary lung tumor showed intense FDG uptake (SUV max , 46), and the small intrapulmonary metastases showed variable FDG uptake (SUV max , 27). Primary pulmonary choriocarcinoma should be included in the differential diagnosis of FDG-avid pulmonary lesions with elevated serum beta human chorionic gonadotropin levels, including metastatic choriocarcinoma and lung cancer.
Mixed selectivity: Cellular computations for complexity
Authors: Kay M. Tye, Earl K. Miller, Felix H. Taschbach, Marcus K. Benna, Mattia Rigotti, Stefano Fusi
Journal: Neuron (2024)

The property of mixed selectivity has been discussed at a computational level and offers a strategy to maximize computational power by adding versatility to the functional role of each neuron. Here, we offer a biologically grounded implementational-level mechanistic explanation for mixed selectivity in neural circuits. We define pure, linear, and nonlinear mixed selectivity and discuss how these response properties can be obtained in simple neural circuits. Neurons that respond to multiple, statistically independent variables display mixed selectivity. If their activity can be expressed as a weighted sum, then they exhibit linear mixed selectivity; otherwise, they exhibit nonlinear mixed selectivity. Neural representations based on diverse nonlinear mixed selectivity are high dimensional; hence, they confer enormous flexibility to a simple downstream readout neural circuit. However, a simple neural circuit cannot possibly encode all possible mixtures of variables simultaneously, as this would require a combinatorially large number of mixed selectivity neurons. Gating mechanisms like oscillations and neuromodulation can solve this problem by dynamically selecting which variables are mixed and transmitted to the readout.
Association of ultra-processed food consumption with all cause and cause specific mortality: population based cohort study
Authors: Zhe Fang, Sinara Laurini Rossato, Dong Hang, Neha Khandpur, Kai Wang, Chun-Han Lo, Walter C Willett, Edward L Giovannucci, Mingyang Song
Journal: BMJ (2024)

To examine the association of ultra-processed food consumption with all cause mortality and cause specific mortality.
Deprescribing in older adults with polypharmacy
Authors: Anna Hung, Yoon Hie Kim, Juliessa M Pavon
Journal: BMJ (2024)

Abstract Polypharmacy is common in older adults and is associated with adverse drug events, cognitive and functional impairment, increased healthcare costs, and increased risk of frailty, falls, hospitalizations, and mortality. Many barriers exist to deprescribing, but increased efforts have been made to develop and implement deprescribing interventions that overcome them. This narrative review describes intervention components and summarizes findings from published randomized controlled trials that have tested deprescribing interventions in older adults with polypharmacy, as well as reports on ongoing trials, guidelines, and resources that can be used to facilitate deprescribing. Most interventions were medication reviews in primary care settings, and many contained components such as shared decision making and/or a focus on patient care priorities, training for healthcare professionals, patient facing education materials, and involvement of family members, representing great heterogeneity in interventions addressing polypharmacy in older adults. Just over half of study interventions were found to perform better than usual care in at least one of their primary outcomes, and most study interventions were assessed over 12 months or less.
Image-based predictive modelling frameworks for personalised drug delivery in cancer therapy
Authors: Ajay Bhandari, Boram Gu, Farshad Moradi Kashkooli, Wenbo Zhan
Journal: Journal of Controlled Release (2024)

Personalised drug delivery enables a tailored treatment plan for each patient compared to conventional drug delivery, where a generic strategy is commonly employed. It can not only achieve precise treatment to improve effectiveness but also reduce the risk of adverse effects to improve patients' quality of life. Drug delivery involves multiple interconnected physiological and physicochemical processes, which span a wide range of time and length scales. How to consider the impact of individual differences on these processes becomes critical. Multiphysics models are an open system that allows well-controlled studies on the individual and combined effects of influencing factors on drug delivery outcomes while accommodating the patient-specific in vivo environment, which is not economically feasible through experimental means. Extensive modelling frameworks have been developed to reveal the underlying mechanisms of drug delivery and optimise effective delivery plans. This review provides an overview of currently available models, their integration with advanced medical imaging modalities, and code packages for personalised drug delivery. The potential to incorporate new technologies (i.e., machine learning) in this field is also addressed for development.
Inhibition of TBL1 cleavage alleviates doxorubicin-induced cardiomyocytes death by regulating the Wnt/β-catenin signal pathway
Authors: Sun-Ho Lee, Jangho Lee, Jaewon Oh, Jin-Taek Hwang, Hae-Jeung Lee, Hwa Kyung Byun, Hyeong-Jin Kim, David Suh, Ho-Geun Yoon, Sahng Wook Park, Seok-Min Kang, Chulan Kwon, Seung-Hyun Lee, Hyo-Kyoung Choi
Journal: Cardiovascular Research (2024)

Doxorubicin (DOX) is a widely used anthracycline anticancer agent; however, its irreversible effects on the heart can result in DOX-induced cardiotoxicity (DICT) after cancer treatment. Unfortunately, the pathophysiology of DICT has not yet been fully elucidated, and there are no effective strategies for its prevention or treatment. In this investigation, the novel role of transducin beta-like protein 1 (TBL1) in developing and regulating DICT was explored.