tbuckley/cabot-search huggingface dataset:
Abstract 8839: Acute Heart Failure: Canadian Perspectives from an RCT and a Registry
Authors: Justin A Ezekowitz, Sean Virani, Rolland Leader, Michael White, Shelley Zieroth, Diego Delgado, Guy Proulx, Jia Hu, Adrian F Hernandez, Cynthia M Westerhout, Christopher M O'Connor, Paul W Armstrong
Journal: Circulation (2011)

Background/Objectives: Randomized controlled trials (RCT) are limited by their generalizability to the broader non-trial population. The recently completed ASCEND-HF RCT provides the first substantive evaluation of care patterns in Canadian patients with acute heart failure (AHF). In order to provide a context for this RCT we designed a complementary registry at the same RCT sites to characterize practice patterns, baseline characteristics and in-hospital outcomes. Methods: Patients with a principal diagnosis of AHF (ICD-9-CM 402 and 428; ICD-10 I50.x, I11.0, I13.0, I13.2) admitted to 7 hospitals participating in ASCEND-HF (n=697 patients, 2007 to 2010; total of 57 one-month sampling periods) were evaluated and compared to ASCEND-HF RCT patients (n=465, 31 sites, 2007 to 2010). Key inclusion criteria for ASCEND-HF were signs and symptoms of HF, &lt;24 hours from admission to emergency or acute care, and if known, and elevated BNP or LVEF&lt;40%. Values are medians with interquartile range (IQR). Results: Patients in the Registry were older, more likely female and have chronic respiratory disease, less likely to have diabetes, and had a similar incidence of ischemic HF, atrial fibrillation and similar BNP levels.(See Table) Median systolic BP and LVEF was higher in Registry vs. RCT patients. Although Registry patients arrived more often via ambulance, they had longer time from triage to 1 st physician consult but a similar total length of stay as RCT patients. In-hospital mortality was much higher in the Registry compared to the RCT patients: 9.3% vs. 1.3%, p&lt;0.001. Conclusions: Patients in a large RCT are typically younger but have a lower LVEF compared with the patients in a Registry from the same Canadian sites. Despite this, the observed in-hospital mortality is higher in unselected Registry as compared to RCT patients highlighting the need for novel strategies applicable to a generalizable AHF population to improve clinical outcomes.
Leukemia-Derived Exosomes Reorganize Bone Marrow Microenvironment In AML
Authors: Bijender Kumar, Lihong Weng, Xiaoman Lewis, Jodi Murakami, Xingbin Hu, Tinisha McDonald, Ashish Kumar, David DiGiusto, Ravi Bhatia, Ching-Cheng Cheng Chen
Journal: Blood (2013)
Abstract 515: Mechanical Dyssynchrony Measured by Gated Single Photon Emission Computed Tomography Phase Analysis Predicts Ventricular Remodeling After Acute ST-Elevation Myocardial Infarction
Authors: Jonathan Murrow, Fabio Esteves, James Galt, Ji Chen, Ernest Garcia, Stamatios Lerakis, Salman Sher, Edmund Waller, Douglas Vaughn, Emerson Perin, James Willerson, Dean Kereiakes, Robert Preti, Andrew Pecora, Arshed A Quyyumi
Journal: Circulation (2009)

Background: Left ventricular dyssynchrony is an adverse consequence of ST elevation myocardial infarction (STEMI) and bears an unfavorable prognosis. Mechanical dyssynchrony as measured by phase an...
The listening healer in the history of psychological healing
Authors: S W Jackson
Journal: American Journal of Psychiatry (1992)

The purpose of this paper is the assessment of the healer's listening as an aspect of the history of caring and curing, with particular attention to its place in psychological healing.An extensive range of philosophical, religious, and medical sources from antiquity to the present were studied.Over the centuries, listening has been a crucial aspect of the various endeavors undertaken by healers in the interest of acquiring information from, achieving understanding of, and bringing about healing effects for sufferers. Yet it has been vision rather than hearing that has been emphasized in knowing and understanding, and looking rather than listening that has been emphasized in healing endeavors. Only around the turn of the twentieth century did there emerge the focused study of care in listening, of listening beyond the words themselves, and of the significance of the interested listener as a soothing, empathic force.The place of listening in depth and with empathy is a crucial element in healing. While the emphasis on looking remains significant in the gathering and appraisal of data, at times it threatens to overwhelm the need for an attentive and concerned listener. There appears to be a natural tension between the two modes that has, in modern times, been translated into a tension between the two modes that has, in modern times, been translated into a tension between a scientific mode of gaining information and a humanistic mode of knowing sufferers. A healer neglects either one at his or her peril--and at the peril of his or her patients.
203. Early Functional and Long-Term Rescue of the LHON Mouse with Wild-Type Human ND4 Gene Delivery
Authors: Rajeshwari D. Koilkonda, Tsung-Han Chou, Marco Ruggeri, Vittorio Porciatti, William W. Hauswirth, Vince Chiodo, Sanford L. Boye, John Guy
Journal: Molecular Therapy (2011)
Concomitant Manifestation of Achalasia and Sphincter of Oddi Dysfunction
Authors: A Kirchgatterer, B Stadler, G Aschl, S Allinger, M Hinterreiter, M Kastner, E Lenglinger, P Knoflach
Journal: Endoscopy (2001)

We report the case of a 44-year-old woman who suffered from biliary-type pain after cholecystectomy, dysphagia, and weight loss. Examinations revealed sphincter of Oddi dysfunction (SOD) and achalasia. Complete relief of symptoms was achieved by endoscopic sphincterotomy and pneumatic dilation of the distal esophagus.
Polyamines regulate sensitivity to HDAC inhibitor-induced apoptosis
Authors: Laura R. Saunders, Eric Verdin
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4655 

Histone deacetylase inhibitors (HDACi) are being developed as novel anticancer agents. To predict which tumors will respond therapeutically to HDACi in the clinic, a better understanding of how these agents induce tumor cell selective apoptosis is urgently needed. Many tumors overexpress ornithine decarboxylase (ODC), the rate limiting enzyme in polyamine biosynthesis, or show elevated ODC activity levels, leading to higher levels of intracellular polyamines. Polyamines are small cations that bind DNA and regulate gene expression and cell proliferation, possibly through regulation of chromatin. To determine whether polyamines levels contribute to sensitivity to HDACi, we used a selective inhibitor of ODC (α-difluoromethylornithine, DFMO) to deplete polyamines from a variety of human tumor cell lines. We found that cells treated with DFMO showed increased resistance to HDACi-induced apoptosis when compared to untreated cells. This effect was due to the depletion of polyamines since re-addition of putrescine to DFMO-treated cells restored their baseline sensitivity to HDACi-induced apoptosis. Polyamine depletion by DFMO treatment induced resistance to difference classes of HDACi, including Trichostatin A, Trapoxin and sodium butyrate, and appeared selective for HDACi, since sensitivity to other chemotherapeutic agents, such as camptothecin, doxorubicin and staurosporine, was not significantly changed by DFMO treatment. Furthermore, we found that intracellular ODC activity correlated with sensitivity to HDACi. We also observed that DFMO-treated cell lines responded to HDACi treatment by an exaggerated response in terms of histone hyperacetylation but not tubulin acetylation. The mechanism underlying this observation is currently being explored. We conclude that intracellular polyamine levels contribute to HDACi-induced apoptosis. The molecular mechanism underlying this finding is currently unknown but is being explored with a particular emphasis on the role of polyamines in the regulation of chromatin acetylation and deacetylation. These results indicate that high ODC activity and/or high polyamines levels might represent a predictive marker for sensitivity of tumors to HDACi.
ABC of labour care
Authors: D. Aldington, D. Brighouse, P. Steer, S. Yentis
Journal: BMJ (1999)

Developing world needs access to low cost pharmaceutical information from reliable sourcesEditor-Hafeez and Mirza have assessed how seriously (or not) pharmaceutical companies take their responsibility to provide information on request to prescribers in Pakistan. 1 Two of their conclusions are that "providing information on drugs is not a priority for companies in Pakistan" and that "the decision to respond to a request for more information therefore seems to depend on how favourable it might be to the interests of the company."These conclusions are particularly worrying because the biased information from drug companies is often the only type of information that prescribers have access to.The findings are in one respect an indictment of the pharmaceutical industry's approach in the developing world.But in another respect, the fact that most prescribers in the developing world do not have adequate access to reliable generic information is an indictment of the international health community.We cannot and should not expect the pharmaceutical industry to provide consistently unbiased information.What is needed is universal access to free or low cost information from a reliable source.As a basic source of reliable prescribing information, the British National Formulary is arguably the single most useful formulary for prescribers worldwide and is one of the BMJ Publishing Group's best sellers internationally.We applaud the recent decision to make the eBNF available on line. 2 If this facility is free it will be a benefit to some prescribers in developing countries, although the effort required to get information online will always be a barrier, even to those few who do have access.Low cost, printed formularies with a quality and objectivity parallel to those of the British National Formulary should be made affordable to all prescribers.Their value and use should be vigorously promoted, not just by the BMJ Publishing Group but by the international health community at large.
Myeloperoxidase potentiates nitric oxide nitrosation of 2-amino-3-methylimidazo[4,5-f]quinoline
Authors: Vijaya M. Lakshmi, Priscilla Dehaven, Terry V. Zenser
Journal: Cancer Research (2004)

761   Colitis (inflammation) and well-done red meat intake (heterocyclic amines) are risk factors for colon cancer. We have recently demonstrated that reactive nitrogen oxygen species (RNOS) nitrosate the heterocyclic amine colon carcinogen 2-amino-3-methylimidazo[4,5- f ]quinoline (IQ) forming 2-nitrosoamino-3-methylimidazo[4,5- f ]quinoline (N-NO-IQ). Because nitrosamines/amides are known to cause GI tumors and N-NO-IQ can be activated by myeloperoxidase (MPO) to form the same DNA adduct as N-HO-IQ (N-(deoxyguanosin-8- yl)-IQ), we propose N-NO-IQ as an alternative to N-OH-IQ initiation of colon cancer, particularly in individuals with colitis. RNOS are formed by the reaction of nitric oxide (NO) with either oxygen or superoxide. While the reaction of NO with superoxide to form peroxynitrite is very fast, the reaction of NO with oxygen (autoxidation) is slow and considered unlikely to occur in vivo. In this study, we evaluated MPO potentiation of NO-mediated IQ nitrosation. DEA NONOate (DEA, 0.1 mM), a NO donor, transformed 0.06 mM  14 C-IQ to N-NO-IQ by autoxidation. With DEA, 85 nM MPO, and 0.1 mM H 2 O 2 , N-NO-IQ formation was increased about 7 to 10-fold with IQ concentrations from 0.02 to 0.2 mM. N-NO-IQ was the only product observed. The affinities of nitrosating species produced by NO for IQ were greater in the presence (-1/X int  = 60 + 6 μM) than absence (-1/X int  = 104 + 10 μM) of MPO. At infinite concentrations of IQ, the maximal rates of N-NO-IQ formation were greater in the presence (1/Y int  = 259 + 15) than absence (1/Y int  = 84 + 5) of MPO. MPO at 25 to 170 nM potentiated N-NO-IQ formation. Different test agents were used to differentiate nitrosation by autoxidation from that observed with MPO. Nitrosation by autoxidation was inhibited 100, 51, and 0 % by 0.3 mM azide, 100 mM NaCl, and 10 ug/ml catalase, respectively. In contrast, MPO-potentiated N-NO-IQ formation was inhibited 42, 0, and 91 % by corresponding concentrations of the same sequence of test agents. Other test agents such as 1 mM glutathione, 0.3 mM ascorbic acid, 0.1 mM NADH, and 30 mM DMPO had similar effects on both pathways. MPO does not metabolize IQ in the absence of NO. However, in the presence of 0.3 mM NO 2  - , an end-product of NO metabolism, MPO metabolizes IQ to two nitroproducts and an IQ dimer. Thus, MPO metabolism of IQ depends upon both the presence and the type of RNOS. Human polymorphonuclear neutrophils (10 6  cells/ml) were incubated with 0.1 mM spermine NONOate and 0.01 mM IQ. Phorbol ester (0.055 mM) increased N-NO-IQ formation 3-fold. This increase was prevented by catalase and further increased to 6-fold with superoxide dismutase. Results demonstrate MPO potentiation of IQ nitrosation. N-NO-IQ formation is dependent upon the inflammatory response; its formation is potentiated by MPO, and its activation to form DNA adducts facilitated by MPO.
Abstract 109: Effect of the Metronome-Guidance on the Quality of Closed Chest Compression During One Person Cardiopulmonary Resuscitation
Authors: Tae Nyoung Chung, Sun Wook Kim, Incheol Park
Journal: Circulation (2010)

Background: The metronome-guidance had been thought as a useful method to enhance the quality of cardiopulmonary resuscitation (CPR) by keeping the pace of chest compression (CC). Recent studies sh...
Abstract 97: Intra-arrest Induction of Therapeutic Hypothermia via Large-Volume, Ice-Cold Saline Infusion Results in Improved Outcomes Among Out-of-Hospital Cardiac Arrests of Cardiac Etiology
Authors: John Freese
Journal: Circulation (2011)

Background: New York City Project Hypothermia is a collaborative effort involving the Fire Department of New York (FDNY), Greater New York Hospital Association, Health and Hospitals Corporation, the Regional Emergency Medical Advisory Committee, and the New York State Department of Health. As part of this effort, the FDNY implemented a new pilot protocol in the New York City 9-1-1 System that introduced the induction of therapeutic hypothermia during initial resuscitation efforts via large-volume ice-cold saline infusion. Purpose: We sought to assess the effects of this protocol on immediate survival end-points following out-of-hospital cardiac arrest (OOHCA) of cardiac etiology. Methods: OOHCA data was analyzed for the following periods: August 1, 2009 - May 31, 2010 (historicalcontrol group) and August 1, 2010 - May 31, 2011 (study group). Except for the intra-arrest induction of hypothermia, no other aspect of the regional resuscitation protocols differed between the two periods. Standard Utstein definitions were utilized. Fisher's exact test was utilized, and a p &lt;0.05 was considered significant. Results: 4,459 / 5,582 (79.9%) of resuscitations during the control period and 3,581 / 4,727 (75.8%) of resuscitations during the study period were of cardiac etiology. The groups did not differ with respect to age, gender, race, response time, bystander witnessed status, or frequency of bystander CPR. Patients in the study period were less likely to have an EMS-witnessed arrest (6.5% vs 7.8%, p=0.03). Return of spontaneous circulation (ROSC) and sustained ROSC were improved in the study group as compared to the control group: 31.1% vs 26.8% (p&lt;0.0001) and 23.6% vs 19.9% (p&lt;0.0001), respectively. Conclusion: The initiation of therapeutic hypothermia via large volume, ice-cold saline infusion improves immediate survival for non-traumatic out-of-hospital cardiac arrest of cardiac etiology. Further study is required to identify specific populations for whom this therapy is most appropriate.
Chronic cough in children: Is it asthma?
Authors: Melanija Zupanic, Marina Praprotnik, Tina Lozej, Uros Krivec
Journal: European Respiratory Journal (2014)

Introduction: Chronic cough is one of the most common complaints in children. It is mostly self-limiting illness. Recent findings show that most children with chronic cough without other respiratory symptoms do not have asthma.

Aims and objectives : In our study, we wanted to find out how common asthma is behind chronic cough in children.

Methods : We reviewed the medical records of all children with chronic cough (cough lasting more than 4 weeks) who were referred to our outpatient clinic from 1st January 2013 to 31st June 2013.

Results: A total of 94 children (54.3 % girls) with the median age 5.0 (range 0.75-17.5) years were included in the study. Skin prick tests were performed in 95.7 % of children (negative in 76.6 %) and FeNO in 80.9 % (negative in 95 %). Spirometry was done in all children older than 5 years (n=54) and it was normal in 90.7 %. Metacholine test was done in 14 children, in 10 it was positive. Sweat test was done in 13 children, all tests were negative. X-ray was performed in 26 children, in 53.8 % it was normal, in others minor changes were found. Microbiology testing was negative in 78.1 % of 24 performed cases.

Of the 94 patients, 58.5 % were diagnosed with postviral cough and 17.1 % with asthma. In others psychogenic cough (19.1 %), GERD (3.2 % and OSAS (2.1 %) were diagnosed.

Conclusions: Detailed history of other respiratory symptoms, positive skin prick tests and/or positive FeNO and/or positive metacholine test revealed that asthma was underlying cause in 17 % of children with chronic cough.
Hepatosplenic T-Cell Lymphoma: Clinicopathological Features and Treatment Outcomes: Report From The North American Peripheral T-Cell Lymphoma Consortium
Authors: Andrei R. Shustov, Wyndham H Wilson, Anne W Beaven, Kerry J. Savage, Kenneth R. Carson, Francisco J. Hernandez-Ilizaliturri, Sindhu Cherian, Ted A. Gooley, Julie M Vose
Journal: Blood (2013)
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes
Authors: Ryan P Hobbs, Daryle J DePianto, Justin T Jacob, Minerva C Han, Byung-Min Chung, Adriana S Batazzi, Brian G Poll, Yajuan Guo, Jingnan Han, SuFey Ong, Wenxin Zheng, Janis M Taube, Daniela Čiháková, Fengyi Wan, Pierre A Coulombe
Journal: Nature Genetics (2015)
A Randomized Phase 3 Trial Of Melphalan-Lenalidomide-Prednisone (MPR) Or Cyclophosphamide-Prednisone-Lenalidomide (CPR) Vs Lenalidomide Plus Dexamethsone (Rd) In Elderly Newly Diagnosed Multiple Myeloma Patients
Authors: Antonio Palumbo, Valeria Magarotto, Sara Bringhen, Massimo Offidani, Giuseppe Pietrantuono, Anna Marina Liberati, Giulia Benevolo, Antonio Ledda, Milena Gilestro, Monica Galli, Francesca Patriarca, Mariella Genuardi, Nicola Giuliani, Renato Zambello, Adam Zdenek, Alessia La Fauci, Paolo Corradini, Antonietta Pia Falcone, Caterina Musolino, Davide Rossi, Patrizia Caraffa, Pellegrino Musto, Federica Cavallo, Roman Hajek, Mario Boccadoro
Journal: Blood (2013)
Abstract 13981: Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profile of Multiple-Doses of DRL-17822, a Potent Cholesteryl Ester Transfer Protein Inhibitor in Healthy Male Subjects
Authors: Mallikarjuna Rao Dasari, Abhijit Bapat, Shivva Vittal, Mangapathiraju Tippana, Sumera Hasham, Sesha Sai M, Shanavas Alikunju, Vasu Sadashivam, Kent Allenby, Rajinder Kumar
Journal: Circulation (2010)
Abstract 2300: Association of Carotid Atherosclerosis With Genetic Polymorphisms of Klotho Gene in Patients With Hypertension and in the General Population
Authors: Ryosuke Oguro, Kei Kamide, Yoshihiro Kokubo, Izumi Shimaoka, Ada Congrains, Mitsuru Ohishi, Tomonori Okamura, Toshiyuki Miyata, Yuhei Kawano, Hiromi Rakugi
Journal: Circulation (2009)
Effects of Novel RAR- and RXR-Selective Retinoids on Myeloid Leukemic Proliferation and Differentiation In Vitro
Authors: Masaaki Shiohara, Marcia I. Dawson, Peter D. Hobbs, Nobukuni Sawai, Tsukasa Higuchi, Kenichi Koike, Atsushi Komiyama, H. Phillip Koeffler
Journal: Blood (1999)
Prostate-Specific Membrane Antigen PET/CT in Splenic Sarcoidosis
Authors: Carsten Kobe, David Maintz, Thomas Fischer, Alexander Drzezga, De-Hua Chang
Journal: Clinical Nuclear Medicine (2015)

A 65-year-old man who had prostate cancer presented with slightly progressive prostate-specific antigen values. In this situation of biochemical relapse, prostate-specific membrane antigen (PSMA) PET/CT has proven to be superior to choline PET. The Ga-PSMA PET/CT of our patient revealed PSMA-positive tissue in the spleen. Although the localization was not typical for metastases, metastasis could not be excluded because of the intense focal tracer uptake. A supplementary MRI was performed but also failed to rule out a malignant origin. Finally, biopsy confirmed benign disease in the spleen in the form of granulomatous disease.
Abstract 3256: Effect of SVC Coil Usage and SVC Electrode Spacing on Defibrillation Thresholds
Authors: Michael Gold, Jesus Val-Mejias, Robert B Leman, Rangarao Tummala, Sanjeev Goyal, Jeffrey Kluger, Mark W Kroll, Ashish Oza
Journal: Circulation (2006)

Background:  Prior studies of active pectoral implantable defibrillator (ICD) lead systems demonstrated a lowering of defibrillation thresholds (DFTs) with the addition of a superior vena cava (SVC) coil. Fixed tilt waveforms were evaluated in these studies, and theoretic modeling suggests that impedance based “tuned” waveform durations may be beneficial by directly changing t he phase durations. The impacts of such tuned waveforms, as well as intercoil spacing, have not been studied previously.   Methods:  This acute, paired-sample, double randomized study included 113 ICD patients, mean age 67 ±13 years, 80% male, LVEF 31±11%, NYHA Class I (12%), II (33%) and III (25%). The patients were randomized at implant into two groups, one with 17 cm intercoil spacing ICD lead and a second with 21 cm intercoil spacing. Patients were also randomized to begin DFT testing with either SVC ON or OFF. DFT testing was performed at implant using a Binary Search Method with the right ventricular (RV) leads placed in the RV apex.   Results:  DFT peak voltage (423±120 V vs. 438±118 V, p=0.045) and shock impedance (41±7 Ω vs. 60±13Ω, p   Conclusions:  The addition of an SVC coil to the shocking pathway reduces the voltage DFTs while not affecting delivered energy requirements. Impedance adjusted waveform durations may be particularly helpful for high impedance pathways. However, intercoil distance had no significant effect on defibrillation parameters.
Abstract 2877: A Novel Intracardiac Pacing Method to Induce and Suppress Repolarization Alternans
Authors: Eric Weiss, Faisal Merchant, Shawna Laferriere, Theofanie Mela, Antonis Armoundas
Journal: Circulation (2009)

Mechanistic links have been advanced between repolarization alternans (RA) and the onset of ventricular tachycardia and fibrillation. Here we demonstrate a novel intracardiac pacing method to contr...
Abstract 13935: Regular Physical Exercise Training Improves Diastolic Function in Pre-Diabetic, Adipose Patients With Coronary Artery Disease
Authors: Robert Hoellriegel, Ephraim Beck, Felix Woitek, Norman Mangner, Sandra Erbs, Matthias Blueher, Michael Stumvoll, Schuler Gerhard, Axel Linke
Journal: Circulation (2011)

Glycosylation of structural myocardial proteins is thought to play a role in the development of diastolic dysfunction (DD) in diabetic patients. Moreover, many obese patients -although not diabetic...