THE USE OF PENICILLIN IN AGRANULOCYTOSIS: CASE REPORT
Authors: R W MOODY, S KAUVAR
Journal: Annals of Internal Medicine (1945)

Case Reports1 December 1945THE USE OF PENICILLIN IN AGRANULOCYTOSIS: CASE REPORTR. W. MOODY, M.D., S. KAUVAR, M.D., F.A.C.P.R. W. MOODY, M.D.Search for more papers by this author, S. KAUVAR, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-6-1015 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany reports of agranulocytosis caused by drug therapy continue to appear in recent medical literature. That aminopyrine can cause this condition has been proved experimentally.1Many of the more recent reports are concerned with the rôle of the sulfonamides as causative factors.2Some experimental evidence of this has been obtained in animals.3, 4Because sepsis develops in patients with agranulocytosis and is the main factor which accounts for the high mortality, the sulfonamides have been used in treatment even when they were the suspected etiological agents.5The use of penicillin for this purpose would seem more logical as it is...Bibliography1. BUTTHOFFSOLL EMAMSN: Experimental production of neutropenia with aminopyrine, Arch. Int. Med., 1939, lxiv, 26-42. CrossrefGoogle Scholar2. RINKOFFSPRING SSM: Toxic depression of the myeloid element following therapy with the sulfonamides: report of eight cases, Ann. Int. Med., 1941, xv, 89-107. Google Scholar3. AXELRODGROSSBOSSESWINGLE AEPMDKF: Treatment of leukopenia and granulopenia in rats receiving sulfaguanidine in purified diets, Jr. Biol. Chem., 1943, cxlviii, 721. CrossrefGoogle Scholar4. DAFTSEBRELL FSWH: The successful treatment of granulocytopenia and leukopenia in rats with crystalline folic acid, Pub. Health Rep., 1943, lviii, 1542. CrossrefGoogle Scholar5. NIXONECKERTHOLMES NJFKB: The treatment of agranulocytosis with sulfadiazine, Am. Jr. Med. Sci., 1943, ccvi, 713. CrossrefGoogle Scholar6. ASTWOOD EB: Treatment of hyperthyroidism with thiourea and thiouracil, Jr. Am. Med. Assoc., 1943, cxxii, 78. CrossrefGoogle Scholar7. NEWCOMBDEANE PBEW: Thiourea causing granulopenia and thrombopenia, Lancet, 1944, i, 179. CrossrefGoogle Scholar8. ROSEMCCONNELL EJ: Thiouracil in treatment of thyrotoxicosis; clinical experience with 37 cases, Am. Jr. Med. Sci., 1944, ccviii, 561-700. Google Scholar9. FORKNER CE: Conferences on therapy. The treatment of blood disorders, Jr. Am. Med. Assoc., 1940, cxv, 126-131. Google Scholar10. BETHELSTURGISMALLORYRUNDLES FHCCOTRW: Blood. A review of the recent literature, Arch. Int. Med., 1944, lxxiv, 131-138. CrossrefGoogle Scholar11. JACKSON H: Leukemia: Agranulocytosis, New England Jr. Med., 1941, ccxxv, 978-982. CrossrefGoogle Scholar12. KEEFER CS: Penicillin in the treatment of infections. Statement by the committee on chemotherapeutic and other agents, Division of Medical Sciences, National Research Council, Jr. Am. Med. Assoc., 1943, cxxii, 1217-1224. CrossrefGoogle Scholar13. SMITHCOHENNICHOLS LBFRG: Agranulocytosis treated with penicillin, Jr. Am. Med. Assoc., 1944, cxxvi, 1027-1028. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colorado*Received for publication March 5, 1945. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1945Volume 23, Issue 6Page: 1015-1017KeywordsDrug therapyMortalityPenicillinSepsisSulfonamide Issue Published: 1 December 1945 PDF DownloadLoading ...