tbuckley/cabot-search huggingface dataset:
Difficult cannulation during endoscopic retrograde cholangiopancreatography – needle knife fistulotomy versus transpancreatic sphincterotomy on the basis of successful cannulation and adverse events
Authors: A. Gustafsson, B. Tingstedt, G. Olsson
Journal: Endoscopy (2024)

Aims When cannulation is difficult in endoscopic retrograde cholangiopancreatography (ERCP) and standard guidewire technique with sphincterotomy is unsuccessful, alternative cannulation techniques must be employed to access the biliary tree. The objective of this study was to compare the frequency of adverse events and the success rates of cannulation between transpancreatic sphincterotomy (TPS) and needle knife sphincterotomy (NKS).
Expert Assessment of Infiltration Depth and Treatment Allocation in Early Barrett Cancer
Authors: F. Younis, R. Thomas, T. Beyna, E. Alanna, S. Faiss, A. May, O. Pech, P. Dautel, A. Mario, C. Till, S. Susanne, S. Guido
Journal: Endoscopy (2024)

Aims Early neoplasia arising from Barrett esophagus (BE) can be curatively treated by endoscopic resection. The choice of the resection technique – endoscopic mucosal resection (EMR) or submucosal dissection (ESD) – largely depends on the assumed infiltration depth of the lesion and hence on preprocedural judgment by the endoscopist. To clarify the accuracy of the endoscopic assessment and treatment allocation, we performed a study showing endoscopic photographs to BE experts simulating a second opinion procedure.
Integrating artificial intelligence with endoscopic ultrasound for the differential diagnosis of pancreatic solid neoplasms
Authors: M. Tacelli, R. Nunziata, A. Vardazaryan, J. P. Mazellier, N. Padoy, P. Arcidiacono
Journal: Endoscopy (2024)

Aims Solid pancreatic lesion incidence has risen in recent years with Pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine neoplasms (PanNENs) representing the two most prevalent, each requiring distinct treatments. Endoscopic ultrasonography (EUS) has proven to be a highly reliable technique for diagnosing pancreatic solid lesions, however, its diagnostic accuracy is constrained by operator experience and moderate interobserver agreement. The increasing popularity of artificial intelligence (AI) in medicine has led to the development of AI-based models capable of processing extensive data volumes, with promising results in various medical applications. This study aimed to assess the effectiveness of our AI-based model in analyzing EUS images of PDAC and PanNENs and distinguishing between the two types of lesions. The secondary aim is to assess the model's capability in lesion segmentation.
Optimization of deep learning architectures for differentiating cytomegalovirus infection in severe ulcerative colitis
Authors: A. R. Choe, G. Kim, B. Ju Ran, P. Yehyun, S. Ki-Nam, A. So-Hyun, J. Sung-Ae
Journal: Endoscopy (2024)

Aims Cytomegalovirus (CMV) reactivation is common in patients with severe ulcerative colitis (UC). Patients with UC exacerbated by reactivated CMV experience worse prognoses than those without CMV reactivation. However, CMV is primarily diagnosed through biopsies, and it can take quite a time to get results, making early diagnosis challenging. To address this, we have conducted research using deep learning to differentiate CMV from severe ulcerative colitis (UC), which has similar features, through endoscopic imaging, enabling early diagnosis of CMV.
Real life adherence to international guidelines in BD-IPMN management. Clinical and costs impact of divergent strategies in BD-IPMN care. The PACMANS Study
Authors: S. Kayali, E. Marabotto, S. Dibitetto, S. Fantasia, A. Busatto, S. Caprioli, A. P. Luzzi, E. Savarino, L. Laghi, C. De Angelis, E. G. Giannini
Journal: Endoscopy (2024)

Aims Over the last two decades, there has been a rise in the diagnosis of Branch Duct Intraductal Papillary Mucinous Neoplasms (BD-IPMN), incidental findings posing potential neoplastic risks. Multiple guidelines, notably the International Association of Pancreatology (IAP)' revised in Fukuoka in 2017, have been suggested to optimize risk management. However, the intricate nature of these guidelines makes adherence challenging, raising uncertainties regarding their application in clinical practice. This study aimed to assess adherence to the 2017 IAP guidelines, identify factors associated with non-compliance, and analyze the impact of divergent strategies on clinical outcomes and costs.
Which endoscopic severity assessment tool correlates best with non-invasive Crohn’s disease activity parameters?
Authors: T. Lima Capela, C. Arieira, T. Gonçalves, J. Goncalves, J. Cotter
Journal: Endoscopy (2024)

Aims Although there are several scores for endoscopic severity assessment in Crohn's disease (CD), there is conflicting and scarce information regarding their agreement and relationship with laboratory non-invasive parameters, namely C-reactive protein (CRP) and fecal calprotectin (FC). We aimed to investigate the agreement between the Simple Endoscopic Score for Crohn's Disease (SES-CD), Modified Multiplier SES-CD (MM-SES-CD), and the recently suggested Toronto Inflammatory Bowel Disease Global Endoscopic Reporting (TIGER) score and their correlation with CRP and FC in CD.
Feasibility, safety, and outcomes of LGI endoscopic submucosal dissection from UK ESD Registry: The largest multicentre prospective study on Western population
Authors: H. Htet, K. Siggens, S. Subramaniam, G. Longcroft-Wheaton, F. Thursby-Pelham, A. Alkandari, M. Baker-Moffatt, J. White, P. B. Adolfo, M. Banks, J. E. East, N. Suzuki, B. Saunders, A. Haji, B. Hayee, P. Bhandari
Journal: Endoscopy (2024)

Aims The outcome of ESD in early gastrointestinal neoplasia in Japan is well established whereas in the west, it is variable depending on the volume and experience. Therefore, a multicentre national registry was set up in the UK to prospectively evaluate the practice and outcomes of ESD.
Surgery versus Endoscopic therapy for Mirizzi Syndrome (SEIZE)-study: A Multicentre International Experience
Authors: M. Bronswijk, J. Tengan, L. Aldrighetti, P. Arcidiacono, M. J. Bruno, F. Cipriani, J. Dhar, S. Everett, C. Gerges, J. Gauci, V. Gupta, M. Hollenbach, G. Johnson, S. Lakhtakia, W. Laleman, W. Lammers, A. Lemmers, J. Omoshoro-Jones, S. Ouazzani, A. Papaefthymiou, E. Perez-Cuadrado Robles, F. Prat, G. Rahe, D. N. Reddy, G. Saelman, J. Samanta, G. Vanella, K. Vermeiren, J. J. Vila, H. van Malenstein, A. Waldthaler, R.L J van Wanrooij, B. M. Zonderhuis, R. Kunda, G. Webster, S. Van der Merwe
Journal: Endoscopy (2024)

Aims The management of Mirizzi syndrome has been primarily surgical, ranging from cholecystectomy to en bloc resection with hepatico-jejunostomy for advanced Csendes III and IV types. The introduction of digital single-operator cholangioscopy (dSOC) allows for ductal clearance in patients with Mirizzi syndrome. Although small series have highlighted the feasibility of an endoscopic approach, there is a lack of comprehensive comparisons between surgical and endoscopic treatments. The objective of the current study is to compare the outcomes and safety of dSOC-guided lithotripsy with the surgical approach.
Endoscopic negative pressure therapy for treatment of Boerhaave&amp;apos;s syndrome: a retrospective multicenter analysis
Authors: A. Wannhoff, K. Kouladouros, R. Koschny, B. Walter, Z. Zoll, K. Büringer, S. Blank, U. Schempf, K. Caca, D. Wichmann
Journal: Endoscopy (2024)

Aims Boerhaave's syndrome is an effort rupture of the esophagus typically caused by heavy vomiting. Mortality without treatment is as high as 90% and even in patients treated with surgery mortality rate is approximately 20%. Endoscopic negative pressure therapy (ENPT) or endoscopic vacuum therapy is successfully used to treat anastomotic leakage after esophageal surgery. Goal of this study was to evaluate ENPT for treatment of Boerhaave's syndrome.
Artificial Intelligence and colorectal neoplasia detection performances in FIT+patients: a meta-analysis and systematic review
Authors: M. Spadaccini, C. Hassan, M. Yuichi, N. Halvorsen, A. Gimeno-Garcia, H. Nakashima, F. Antonio, A. Schilirò, M. Menini, D. M. Alessandro, G. franchellucci, G. Antonelli, K. Kareem, T. Rizkala, D. Ramai, R. Emanuele, K. Shunsuke, L. Correale, M. Bretthauer, B. Pradeep, S. Prateek, D. K. Rex, A. Repici
Journal: Endoscopy (2024)

Aims The combination of fecal immunochemical test (FIT) followed by a colonoscopy has established itself as one of the preferred population-based screening strategies. Optimizing endoscopists' detection performances is essential for enhancing the effectiveness of Colorectal Cancer (CRC) screening programs in reducing incidence and mortality due to CRC. Despite extensive exploration of various techniques and technologies (ie mucosal exposure devices, chromoendoscopy), their impact on adenoma detection rate (ADR) has shown inconsistency across studies in this specific setting -FIT+population-. The aim of this meta-analysis is pooling data of all the randomized trials focused on this strategic subpopulation in order to address whether the implementation of a CADe system may increase the identification of CR neoplasia precursors within a structured colorectal cancer screening program based on FIT.
Outcomes of Anastomotic Leakage after Esophagectomy Before and After implementation of Endoscopic Vacuum Therapy in a Tertiary Referral Center
Authors: L. M. Pattynama, R. Pouw, S. Gisbertz, F. Daams, J. Bergman, M. Van Berge Henegouwen, W. J. Eshuis
Journal: Endoscopy (2024)

Aims Anastomotic leakage (AL) after esophagectomy is associated with severe morbidity and a high mortality [1] [2]. Endoscopic vacuum therapy (EVT) has recently been established as a promising endoscopic treatment option for AL, with success rates of higher than 80% [3] [4]. The aim of this study was to compare outcomes of AL after esophagectomy, before and after implementation of EVT.
Automatic detection of pancreatic ductal adenocarcinoma in endoscopic ultrasound guided fine needle biopsy samples based on whole slide imaging using deep learning segmentation architectures
Authors: N. Podină, A. L. Udriștoiu, B. S. Ungureanu, A. L. Constantin, C. V. Georgescu, N. Bejinariu, D. Pirici, D. E. Burtea, L. Gruionu, Ș. Udriștoiu, A. Săftoiu
Journal: Endoscopy (2024)

Aims Endoscopic ultrasound (EUS) guided fine needle biopsy (FNB) is the procedure of choice for the diagnosis of pancreatic ductal adenocarcinoma (PDAC). The samples obtained are small and require expertise in pathology, whilst the diagnosis is difficult in view of the scarcity of malignant cells and the important desmoplastic reaction of these tumors. Moreover, the limited availability of publicly accessible datasets containing pancreatic histopathological images has resulted in a scarcity of research on the automated detection of PDAC, especially based on whole slide imaging (WSI). In this study, a comparison of three U-Net architecture variants was performed on two different datasets of EUS-guided FNB samples from two medical centers (Craiova and Bucharest) with different parameters and acquisition tools. The obtained WSIs are multi-gigabyte images with typical resolutions of 40,000×40,000 pixels, used to train and evaluate the segmentation models.
A comparative study benchmarking colon polyp detection with CADe software
Authors: N. Papachrysos, P. H. Smedsrud, K. Anonsen, T. J. Berstad, H. Espeland, A. Petlund, P. Hedenström, P. Halvorsen, J. Varkey, H. Hammer, M. Riegler, T. de Lange
Journal: Endoscopy (2024)

Aims Some studies have shown that Computer-Aided Detection software (CADe) for real-time colonic polyp detection improves polyp detection and adenoma detection rate (ADR), but no head-to-head comparison of different commercially available CADe systems has been performed. This study aims to compare the performance of three different polyp detection systems using a novel standardized methodology.
Accuracy of PanMayo endoscopic score in predicting long-term disease outcomes in ulcerative colitis – a promising scoring system
Authors: P. Bacsur, P. Wetwittayakhlang, T. Resál, B. Vasas, B. Farkas, M. Rutka, T. Bessissow, W. Afif, A. Bálint, A. Fábián, R. Bor, Z. Szepes, K. Farkas, P. L. Lakatos, T. Molnár
Journal: Endoscopy (2024)

Aims Colonoscopy plays a crucial role in management of ulcerative colitis (UC) that helps to assess mucosal healing. Different scoring systems are available to assess severity, however most of them do not correlate with disease extent. Our study aimed to assess the predictive value and accuracy of PanMayo score compared to MES, UCEIS and Dublin in mid- and long-term disease outcomes.
Elective endoscopic gallbladder treatment for benign diseases in patients at high surgical risk and an indication to perform cholecystectomy: a prospective multicenter study
Authors: G. Tripodi, G. Rizzatti, A. Lisotti, G. Valerii, C. Barbera, V. M. Jorge, M. Benedetto, P. Fusaroli, K.D. C. Pham, C. Spada, A. Larghi
Journal: Endoscopy (2024)

Aims EUS-guided gallbladder drainage (EUS-GBD) is the procedure of choice to treat patients with acute cholecystitis (AC) at high surgical risk.), We have recently shown in a retrospective multicenter study that elective endoscopic gallbladder treatment (EEGBT) is safe and effective in patients with benign gallbladder diseases at high surgical risk. We aimed to prospectively assess safety and efficacy of EEGBT in a large cohort of patients with benign gallbladder diseases at high surgical risk and an indication to perform cholecystectomy.
The AI-based Red Density score is correlated with the established and new histological indices for ulcerative colitis in an independent cohort
Authors: P. Sinonquel, P. Bossuyt, S. John, M. Iacucci, U. Shivaji, G. De Hertogh, S. Van Aelst, S. Pillai, Z. Abdawn, S. Sugita, S. Mccartney, A. Armuzzi, T. Bessissow, T. Rath, D. H. Yang, S. Vermeire, H. Nakase, R. Bisschops
Journal: Endoscopy (2024)

Aims Red Density (RD) is an automated endoscopic tool that is developed for the objective evaluation of disease activity in ulcerative colitis (UC). Initial development was based on an algorithm including histological disease activity based on Robarts histological index (RHI). New histological scores for UC have been developed since. We aimed to establish the correlation between RD and the Nancy histological index (NHI) and PICaSSO Histologic Remission Index (PHRI).
Pancreatic Organoids establishment from EUS Fine Needle Biopsy in patients affected by Pancreatic Cancer: Preliminary results from the Bile Biopsy study
Authors: C. Binda, P. Giuffrida, M. Zanoni, G. Marisi, C. Coluccio, B. Perini, S. Fabbri, G. Gibiino, F. Limarzi, A. Vizzuso, I. G. Rapposelli, E. Giampalma, M. Cricca, C. Cammà, V. Sambri, P. Ulivi, C. Fabbri
Journal: Endoscopy (2024)

Aims We performed a prospective observational study aiming to evaluate the feasibility to create tridimensional pancreatic derives organois (PDOs) from EUS guided FNB samples of patients affected by PDAC and to correlate patients derived organoids (PDOs) with native cancer histology. The secondary endpoint of our study was to assess the feasibility of using bile as biological fluid for cell free DNA (cfDNA) and to investigate the landscape of cfDNA in bile and plasma of patients affected by PDAC.
Endoscopic submucosal dissection with adaptive traction: first prospective multicenter study
Authors: J. Grimaldi, L. J. Masgnaux, T. Wallenhorst, R. Legros, R. Jerome, J. Jacques, P. Mathieu
Journal: Endoscopy (2024)

Aims Traction has become the reference strategy for colorectal endoscopic submucosal dissection (ESD). One of its main limitations is that the power of traction decreases as dissection progresses. The ATRACT traction device uses a pulley system to increase traction during the procedure, making it simpler and faster. A retrospective study of 54 cases revealed interesting results in terms of efficacy and safety throughout the digestive tract.
Artificial Intelligence (AI) improves endoscopists’ vessel detection during endoscopic submucosal dissection (ESD)
Authors: M. W. Scheppach, R. Mendel, D. Rauber, A. Probst, S. Nagl, C. Römmele, M. Meinikheim, C. Palm, H. Messmann, A. Ebigbo
Journal: Endoscopy (2024)

Aims While AI has been successfully implemented in detecting and characterizing colonic polyps, its role in therapeutic endoscopy remains to be elucidated. Especially third space endoscopy procedures like ESD and peroral endoscopic myotomy (POEM) pose a technical challenge and the risk of operator-dependent complications like intraprocedural bleeding and perforation. Therefore, we aimed at developing an AI-algorithm for intraprocedural real time vessel detection during ESD and POEM.
Randomized clinical trial comparing ERCP vs ERCP plus EUS-guided gallbladder drainage in non-surgical patients with symptomatic choledocholitiasis: mid-term analysis
Authors: F. J. García-Alonso, A. Martinez-Ortega, S. Bazaga, M. Cobreros del Caz, J. R. Aparicio, R. Sánchez-Ocaña, R. Grajal Marino, J. J. Vila, B. Martínez-Moreno, C. Chavarría, C. De La Serna Higuera, M. Perez-Miranda
Journal: Endoscopy (2024)

Aims ERCP remains the primary approach tocholedocolithiasis. 30% of patients who undergo clearance of choledocholitiasis by ERCP without subsequent cholecystectomy will suffer recurrent biliary events. We hypothesized that EUS-guided gallbladder drainage (EUS-GBD) performed in the same endoscopic procedure could significantly decrease this risk.
Two-year outcomes of endoscopic transpapillary gallbladder stenting versus EUS-guided transmural gallbladder drainage in high-surgical risk patients with acute calculous cholecystitis: a randomized trial
Authors: J. Chaikajornwat, W. Ridtitid, P. Piyachaturawat, P. Vongwattanakit, S. Kulpatcharapong, P. Angsuwatcharakon, P. Mekaroonkamol, P. Kongkam, R. Rerknimitr
Journal: Endoscopy (2024)

Aims Endoscopic transpapillary gallbladder stenting (ETGS) and endoscopic ultrasound-guided transmural stenting (EUGS) can be performed as an alternative gallbladder drainage in high-surgical risk patients with acute calculous cholecystitis (AC). However, the durability of these two endoscopic treatments has not been compared.
Randomized controlled trial comparing conventional and underwater endoscopic submucosal dissection for superficial colorectal neoplasms
Authors: M. Nagata
Journal: Endoscopy (2024)

Aims Conventional endoscopic submucosal dissection (C-ESD) is performed under gas conditions. However, the newly developed underwater ESD (U-ESD) has advantages, including a clear visual field without halation, buoyancy, easy use of water pressure for opening the mucosal cutting edge, and heat-sink effects. The usefulness of U-ESD for superficial colorectal neoplasms (SCNs) has been reported, but few studies have compared it with C-ESD. This study aimed to investigate whether U-ESD improves the procedure-related outcomes compared with that of C-ESD in patients with SCNs.
Conversion of percutaneous cholecystostomy (PC) to endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) vs conservative management after acute calculous cholecystitis (ACC) in non-surgical patients
Authors: B. Burgueño, M. De Benito Sanz, M. Alvarez, C. Hurtado-Gomez, M. Moreta, N. Marcos-Carrasco, C. Martinez-Cuevas, S. J. Fernández Prada, E. Fuentes-Valenzuela, C. Suarez-Cabrera, L. Villalonga, D. Muñoz, S. Bazaga, C. Chavarría, A. J. Velasco-Guardado, C. De La Serna Higuera, M. Perez-Miranda
Journal: Endoscopy (2024)

Aims In nonsurgical patients with ACC, PC is an effective therapeutic option. After removal of PC catheters, however, the recurrence rate of biliopancreatic events (BPE) is up to 40-50% overall, and 25% after ACC. Routine internalization of PC by conversion to EUS-GBD could become a definitive treatment strategy in this setting.
Between the third and second space: an endoscopic submucosal dissection (ESD) with mesorectal space exposure of a recurrent circumferential lesion of the rectum
Authors: S. Sferrazza, G. Calabrese, M. Amata, E. Conte, A. Calì, F. Mocciaro, D. Scimeca, A. Bonaccorso, B. Scrivo, V. Di Martino, F. Vieceli, M. Maida, R. Di Mitri
Journal: Endoscopy (2024)

Abstract Text A 70-year-old man underwent colonoscopy in 2020 for diarrhoea. The colonoscopy detected a semi-circumferential granular rectal polyp at the lower rectum that was treated with trans-anal endoscopic microsurgery (TEM) at another Institution, after multiple endoscopic resection attempts. Endoscopic surveillance in 2023 revealed a locally recurrent circumferential adenoma extending beyond the dentate line and involving multiple traction areas due to the previous surgery. Patient was referred to our Institution to evaluate an endoscopic treatment and avoid Miles' surgery. ESD with partial full-thickness resection was proposed. Circumferential ESD with mesorectal exposure was performed obtaining an en bloc resection (R0). Afterwards, the patient showed symptoms due to stenosis, which was treated with mechanical dilation in outpatient settings.
Comparison of laparo-endoscopic rendez-vous vs. a two-step approach in cholecysto-choledocholithiasis
Authors: M. Staessens, L. Van Overbeke, J. Ceulemans, L. Verheyen, T. Spiessens, S. Francque, E. Macken, L. Verbeke
Journal: Endoscopy (2024)

Aims The treatment of gallstones consists of an endoscopic retrograde cholangiopancreatography (ERCP) to extract choledocholithiasis (CDL) and a cholecystectomy (CCE) to prevent disease recurrence. Amongst the most feared and frequent complications of performing an ERCP is a post-ERCP pancreatitis (PEP). In this study, we compared a single step CCE+ERCP via rendez-vous technique to a two-step procedure to assess the risk of PEP.The treatment of gallstones consists of an endoscopic retrograde cholangiopancreatography (ERCP) to extract choledocholithiasis (CDL) and a cholecystectomy (CCE) to prevent disease recurrence. Amongst the most feared and frequent complications of performing an ERCP is a post-ERCP pancreatitis (PEP). In this study, we compared a single step CCE+ERCP via rendez-vous technique to a two-step procedure to assess the risk of PEP.
Endoscopic gastroyeyunostomy and pyloric exclusion with the OverStitch system after refractory duodenal perforation in a fragile patient
Authors: B. Martínez-Moreno, L. Guilabert, L. Company, C. Mangas, J. Martinez Sempere, F. Ruiz, J. R. Aparicio
Journal: Endoscopy (2024)

Abstract Text Case description: An 86-year-old non-surgical male was admitted with an extensive duodenal perforation. A conservative approach with percutaneous drainage and endoscopic management was chosen. After failed duodenal stents, exclusion of the duodenal transit by pyloric closure with the OverStitch system and a creation of a new enteric anastomosis with a USE-Gastroenterostomy (USE-GE) was decided. The pyloric closure was strengthened with additional sutures in two consecutive sessions. Complete sealing allowed removal of the pigtail.
Artificial Intelligence Assisted Capsule Endoscopy Versus Conventional Endoscopy for Detection of Small Bowel Lesions – Systematic Review and Meta-analysis
Authors: A. Dhali, V. Kipkorir, B. S. Srichawla, H. Kumar, J. Biswas, R. B Rathna, C. Rugut, T. Chaudhry, G. Morara, I. Ongidi, M. Waithaka, S. Ray, G. K. Dhali
Journal: Endoscopy (2024)

Aims The study aims to systematically review literature and provide a meta-analysis on the diagnostic accuracy,specificity, sensitivity, negative and positive predictive values of AI-assisted capsule endoscopy (CE) in the diagnosis of small bowel lesions in comparison to CE.
Feasibility of endoscopic ultrasound-guided fine needle biopsy for generating patient-derived organoids of pancreatic ductal adenocarcinoma: preliminary results from a single-center prospective database
Authors: F. Borrelli de Andreis, V. Panzeri, V. Ruta, E. Cesari, F. Attili, C. Spada, C. Sette
Journal: Endoscopy (2024)

Aims Pancreatic ductal adenocarcinoma (PDAC) is notorious for its aggressive nature and grim prognosis, underscoring the urgent need for personalized pre-clinical models to develop targeted therapies. Patient-derived organoids (PDOs) are three-dimensional models of human tumors that have emerged as promising research tools. We therefore aimed to assess the feasibility of endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) for generating PDAC-PDOs.