tbuckley/cabot-search huggingface dataset:
Cutaneous toxicities associated with epidermal growth factor receptor (EGFR) and mesenchymal epithelial transition factor (MET) dual blockade via bispecific antibody amivantamab
Authors: Isabel Arana, Grant J Riew, Adam Rock, Vinod E Nambudiri, Badri Modi, Connie R Shi
Journal: Journal of the American Academy of Dermatology (2025)
Antifungal therapy patterns, healthcare utilization, costs, and mortality in central nervous system and non-central nervous system disseminated coccidioidomycosis across the continuum-of-care
Authors: Fariba Donovan, Mark Bresnik, Belinda Lovelace, Lia Pizzicato, Vamshi Ruthwik Anupindi, Mitchell DeKoven, Craig I Coleman
Journal: Clinical Microbiology and Infection (2025)
Beyond the Diagnosis: A Skin of Color Patient's Journey with Acral Lentiginous Melanoma
Authors: Sharon Lopez, Sach Thakker, Kira Minkis
Journal: British Journal of Dermatology (2025)

This article explores a patient's experience with acral lentiginous melanoma (ALM), highlighting the challenges of diagnosis and treatment in individuals with darker skin tones. The patient narrative emphasizes the emotional and physical toll of the disease, while the clinician's perspective underscores the importance of early detection, comprehensive care, and awareness of racial disparities in ALM outcomes. The piece advocates for heightened vigilance among healthcare providers and the need for multidisciplinary approaches to optimize patient care and support.
Brexucabtagene autoleucel versus allogeneic hematopoietic cell transplantation in relapsed and refractory mantle cell lymphoma
Authors: Nora Liebers, Ariane Boumendil, Hervé Finel, Dominic Edelmann, Guido Kobbe, Ben-Niklas Baermann, Yasmina Serroukh, Didier Blaise, Dietrich Wilhelm. Beelen, Carlos Solano, Maija Itälä-Remes, Tom van Meerten, Goda Choi, Susanne A C. Schmidt, Nicolaus Kröger, Jenny Byrne, Jean-Jacques Tudesq, Anna Ossami Saidy, Ana Nunes, Rubina Siddiqi, Elande Baro, Dan Zheng, Ioana Kloos, Peter Dreger, Anna Sureda, Bertram Glass, Sascha Dietrich
Journal: Blood Cancer Discovery (2025)

Abstract Brexucabtagene autoleucel (brexu-cel) and allogeneic hematopoietic cell transplantation (alloHCT) are effective treatments for relapsed or refractory mantle cell lymphoma (r/r MCL), but the optimal choice remains unclear. We conducted an analysis of 64 r/r MCL patients aged ≥50 years treated with brexu-cel in the ZUMA-2 study, matching them 1:1 by propensity score to 64 (out of 272) r/r MCL patients who underwent alloHCT using data from the EBMT registry. Median follow-up time was 36.5 and 34.1 months for the brexu-cel and matched alloHCT cohort, respectively. Brexu-cel patients had a significantly higher overall survival (OS, 81.3% vs 59.2%, HR: 0.39, p=0.004) and lower non-relapse mortality (3.6% vs 21.2%, p=0.015) one year after treatment. Chronic graft-vs-host disease occurred in 26.9% of alloHCT patients within the first year. However, long-term progression-free survival and OS remain comparable. Despite limitations of this non-randomized study, it indicates a superior safety profile for brexu-cel in r/r MCL.
Risk of developing sleep disorders and psychologic comorbidity in children with inflammatory skin diseases - a population-based study
Authors: Caroline Mann, Andreas Wollenberg, Sascha Ständer, Petra Staubach, Diamant Thaçi, Henner Zirpel
Journal: Journal of the American Academy of Dermatology (2025)

Inflammatory skin diseases such as atopic dermatitis (AD), psoriasis and urticaria are associated with impaired mental health and sleep. In children the risk of developing these comorbidities is still poorly evaluated. Retrospective data analysis of a US Collaborative Network including children of 55 Health care providers was performed. Data from electronic health records of patients with a diagnosis of either AD, psoriasis, or urticaria, as well as a control cohort were retrieved in an anonymized batch format and propensity score matched. Children with psoriasis had a 3.2-fold higher risk for hypersomnia, 2.1-fold higher for sleep apnea, 1.8-fold higher for fatigue and 1.9-fold higher for depression. Children with urticaria (acute or chronic) and AD had a 1.7-fold higher risk for sleep disorders, 1.6 higher for anxiety disorders and 1.4-fold higher for insomnia. AD children had a 1.5-fold higher risk for anxiety disorders. Electronic health insurance data are not subject to random sampling of the general population and potential misdiagnosis is possible. Children with inflammatory skin diseases were at a higher risk for sleep psychological disorders. Thus, regularly performed screenings and appropriate treatment initiation might potentially prevent mental and physical health consequences and secure improved life quality.
Efficacy of oral rinse and other detection methods in detecting oral human papillomavirus infections: the Oromouth cohort study
Authors: Bethany Hillier, Tim Waterboer, Jill Brooks, Paul Nankivell, Ridhi Agarwal, Ahmad K. Abou-Foul, Tessa Fulton-Lieuw, Caroline Kristunas, Alex Vorsters, Pasquale Cacciatore, Joanna Parish, Hisham Mehanna
Journal: Journal of Infection (2025)

Highlights•Oral rinse is the most common measure for estimating oral HPV prevalence.•We compared oral rinse to pharyngeal wall and tongue base brushes, & tonsil tissue.•Combining all four oral sites, any HPV and HR-HPV prevalence were 18% and 4.3%.•Oral rinse misses 73% (11/15) of HR-HPV cases detected by the other oral sites.•All 4 sample types combined improves HR-HPV detection over oral rinse alone by 38%.AbstractObjectivesHuman papillomavirus (HPV) mediated oropharyngeal cancer (OPC) incidence has increased dramatically. Accurate oral HPV prevalence data are essential for assessing population epidemiology, vaccination and screening programmes. As oral rinse is the most commonly used primary outcome measure for estimating oral HPV prevalence, we aimed to compare the efficacy of oral rinse against other detection methods.MethodsThe Oromouth study enrolled 945 participants, aged 0-65 years (63% female), undergoing tonsillectomy for non-malignant indications, without OPC diagnoses. Samples from oral rinse, pharyngeal wall, tongue base, tonsil tissue and blood were collected. HPV DNA in oral samples was centrally tested via polymerase chain reaction, and serology samples for HPV antibodies. Statistical analyses assessed prevalence, detection rates and ratios.ResultsCombining all four oral collection sites, high-risk (HR)-HPV and any HPV prevalence were 4·3% and 18%, respectively. HR-HPV prevalence was similar between males (4·1%) and females (4·5%). Oral rinse had the highest HR-HPV (4·0%) and any HPV detection rates (16%), but still missed 73% (11/15) identified as HR-HPV-positive by other oral sites. Compared to oral rinse alone, an additional 38% (11/29) HR-HPV infections were picked up by the other three oral collection methods. Addition of serology testing did not result in substantial improvement.ConclusionsOf the four oral sites, oral rinse demonstrates the highest detection rates by far but has important limitations. These findings should be taken into consideration when estimating oral HPV infection rates, especially for vaccination studies and screening programmes.
Risk of Incident Diabetes Related to Lipoprotein(a), LDL Cholesterol, and Their Changes With Alirocumab: Post Hoc Analyses of the ODYSSEY OUTCOMES Randomized Trial
Authors: Gregory G. Schwartz, Michael Szarek, J. Wouter Jukema, Christa M. Cobbaert, Esther Reijnders, Vera A. Bittner, Markus Schwertfeger, Deepak L. Bhatt, Sergio Fazio, Genevieve Garon, Shaun G. Goodman, Robert A. Harrington, Harvey D. White, Philippe Gabriel Steg
Journal: Diabetes Care (2025)

OBJECTIVE Previous genetic and clinical analyses have associated lower lipoprotein(a) and LDL cholesterol (LDL-C) with greater risk of new-onset type 2 diabetes (NOD). However, PCSK9 inhibitors such as alirocumab lower both lipoprotein(a) and LDL-C without effect on NOD. RESEARCH DESIGN AND METHODS In a post hoc analysis of the ODYSSEY OUTCOMES trial (NCT01663402), we examined the joint prediction of NOD by baseline lipoprotein(a), LDL-C, and insulin (or HOMA–insulin resistance [HOMA-IR]) and their changes with alirocumab treatment. Analyses included 8,107 patients with recent acute coronary syndrome on optimized statin therapy, without diabetes at baseline, assigned to alirocumab or placebo with median follow-up 2.4 years. Splines were estimated from logistic regression models. RESULTS Lower baseline lipoprotein(a) and higher baseline insulin or HOMA-IR independently predicted 782 cases of NOD; baseline LDL-C did not predict NOD. Alirocumab reduced lipoprotein(a) and LDL-C without affecting insulin or NOD risk (odds ratio [OR] vs. placebo 0.998; 95% CI 0.860–1.158). However, in logistic regression, decreased lipoprotein(a) and LDL-C on alirocumab were independent, opposite predictors of NOD. OR for NOD for 25% and 50% lipoprotein(a) reductions on alirocumab were 1.12 (95% CI 1.01–1.23) and 1.24 (1.02–1.52). OR for NOD for 25% and 50% LDL-C reductions on alirocumab were 0.88 (95% CI 0.80–0.97) and 0.77 (0.64–0.94). CONCLUSIONS Baseline lipoprotein(a) was inversely associated with risk of NOD. Alirocumab-induced reductions of lipoprotein(a) and LDL-C were associated with increased and decreased risk of NOD, respectively, without net effect on NOD. Ongoing trials will determine the impact of larger and longer lipoprotein(a) reductions on NOD.
Challenges with reinforcement learning model transportability for sepsis treatment in emergency care
Authors: Peter C. Nauka, Jason N. Kennedy, Emily B. Brant, Matthieu Komorowski, Romain Pirracchio, Derek C. Angus, Christopher W. Seymour
Journal: npj Digital Medicine (2025)

Pivotal moments in sepsis care occur in the emergency department (ED), however, and it is unclear whether ED data is adequate to inform reinforcement learning (RL) models. We evaluated the early opportunity for the AI Clinician, a validated ICU-based RL-model, as a use case. Amongst emergency sepsis patients, model parameters were often missing and invariably measured. Current iterations of RL-models trained on ICU data face challenges in emergency sepsis care.
Identifying the sweet spot in portal pressure reduction with TIPS
Authors: Louise China, David Patch
Journal: Hepatology (2025)

1The Royal Free Hospital, London 2University College London Abbreviations: HE, hepatic encephalopathy; MASLD, metabolic associated steatotic liver disease; mmHg, millimetres of mercury; PPG, portal pressure gradient; TIPS, Transjugular intrahepatic portosystemic shunt; WHVP, wedge hepatic pressure measurement Correspondence Louise China, University College London, ; Royal Free London NHS, Foundation Trust. Email: [email protected]
Combination Immunotherapy With Nivolumab Plus Ipilimumab in Melanoma of Unknown Primary
Authors: Sapna P. Patel, Rahul A. Sheth, Christina Davis, Theresa Medina
Journal: Journal of Clinical Oncology (2025)

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology , to patients seen in their own clinical practice .
Prognostic implications of risk definitions from the monarchE and NATALEE trials
Authors: Luca Arecco, Eva Blondeaux, Marco Bruzzone, Grazia Arpino, Carmine De Angelis, Michelino De Laurentiis, Roberta Caputo, Alessandra Fabi, Valeria Sanna, Stefania Gori, Fabio Puglisi, Luca Boni, Simone Nardin, Irene Giannubilo, Marta Perachino, Roberto Borea, Elisa Agostinetto, Evandro de Azambuja, Matteo Lambertini, Lucia Del Mastro
Journal: JNCI Journal of the National Cancer Institute (2025)

The monarchE and NATALEE trials employed different high-risk inclusion criteria. Main objective is to assess prognostic differences based on their inclusion criteria. Patients with hormone receptor-positive/HER2-negative early breast cancer enrolled in the phase III MIG1, GIM2, and GIM3 trials were categorized as high-risk cohort (HRC) and low-risk cohort (LRC) according to the inclusion criteria of monarchE and NATALEE trials. Subsequently, they were further classified in three different cohortsconcordant LRC (low-risk for both trials), discordant risk cohort (high-risk for only one trial), and concordant HRC (high-risk for both trials). Main outcomes were disease-free survival (DFS) and overall survival (OS). Among 4,795 patients included, 1,343 (28.0%) and 2,689 (56.1%) were classified as HRC according to the monarchE and NATALEE, respectively.
Normobaric hyperoxia combined with endovascular treatment for acute ischaemic stroke in China (OPENS-2 trial): a multicentre, randomised, single-blind, sham-controlled trial
Authors: Weili Li, Jing Lan, Ming Wei, Lan Liu, Chengbei Hou, Zhifeng Qi, Chuanhui Li, Liqun Jiao, Qi Yang, Wenhuo Chen, Shuling Liu, Xincan Yue, Qinglin Dong, Haicheng Yuan, Zongen Gao, Xiangbin Wu, Changming Wen, Tong Li, Changchun Jiang, Di Li, Zuoquan Chen, Junfeng Shi, Wanchao Shi, Jinglin Yuan, Yijie Qin, Binglong Li, Marc Fisher, Wuwei Feng, Ke Jian Liu, Xunming Ji, Weili Li, Jing Lan, Ming Wei, Lan Liu, Chengbei Hou, Zhifeng Qi, Chuanhui Li, Liqun Jiao, Qi Yang, Wenhuo Chen, Shuling Liu, Xincan Yue, Qinglin Dong, Haicheng Yuan, Zongen Gao, Xiangbin Wu, Changming Wen, Tong Li, Changchun Jiang, Di Li, Zuoquan Chen, Junfeng Shi, Wanchao Shi, Jinglin Yuan, Yijie Qin, Binglong Li, Marc Fisher, Wuwei Feng, Ke Jian Liu, Xunming Ji, Qingfeng Ma, Chuanjie Wu, Wenbo Zhao, Jian Chen, Wenbo Hu, Mingchao Ding, Sifei Wang, Yanmin Wu, Biao Li, Qingcheng Yang, Weizheng Xie, Shiyong Zhang, Ji Ma, Ligong Gao, Jing Chen, Wenbo Li, Xuxu Wu, Jianglong Tu, Min Yin, Rui Huang, Xinwei He, Hanzhang Wang, Ling Yu, Weikang Tan, Shengbin Wu, Ming Mo, Rui Shen, Haihua Yang, Yuting Hou, Shuai Zhu, Mengmeng Shi, Jing Zhou
Journal: The Lancet (2025)
Life expectancy and mortality among males and females with HIV in British Columbia in 1996–2020: a population-based cohort study
Authors: Katherine W Kooij, Wendy Zhang, Jason Trigg, Nance Cunningham, Michael O Budu, Megan E Marziali, Viviane Dias Lima, Kate A Salters, Rolando Barrios, Julio S G Montaner, Robert S Hogg
Journal: The Lancet Public Health (2025)

SummaryBackgroundLife expectancy of people with HIV has increased considerably. We used data from the Comparative Outcomes And Service Utilization Trends (COAST) study to examine sex differences in life expectancy and mortality between 1996 and 2020 among people with HIV in British Columbia (BC), Canada.MethodsCOAST, a population-based cohort study, includes clinical and administrative health data on virtually all people with HIV in BC. We calculated life expectancy for people with HIV at ages 20, 40, and 55 years stratified by sex and calendar period. We used Cox regression to model associations between sex and all-cause and cause-specific mortality, adjusting for individual and social determinants of health.Findings11 738 males (82·2%) and 2534 females (17·8%) of 14 272 people with HIV, aged ≥20 years, were included. Life expectancy at age 20 years for males increased by 23·54 years from 1996–2001 to 2012–20 (from 24·46 years to 48·00 years), but life expectancy for females in that period increased only by 18·81 years (from 22·13 years to 40·94 years). Similarly, life expectancy at ages 40 years and 55 years increased over time in all strata but remained lower among females than males. The sex-gap in life expectancy at ages 20 and 40 years increased over time. The association between female sex and all-cause mortality was attenuated but remained statistically significant after adjusting for individual and social determinants of health (hazard ratio 1·11 [95% CI 1·03–1·20]).InterpretationAlthough life expectancy among people with HIV in BC increased between 1996 and 2020, life expectancy of females remained lower than males with the gap between them increasing over time. Sex differences in all-cause mortality were partially explained by differences in known socio-structural determinants and immune status. Women with HIV should be considered a priority for public health strategies to address structural factors with adverse health impact.FundingCanadian Institutes of Health Research (CIHR), Health Research BC, CIHR Canadian HIV Trials Network, and National Institutes of Health.
Pathogens don't respect politicians: US federal disruption poses a new threat to global public health
Authors: Su Wang, Mark Harrington, Camilla S Graham, Louise O Downs, Nancy Kagwanja, Anthony O Etyang, Collins Iwuji, Thumbi Ndung'u, Benjamin C Cowie, Kenneth Kabagambe, Philippa C Matthews
Journal: The Lancet. Gastroenterology & hepatology (2025)
Adenoma with complete circumferential involvement of the ileum and ileocecal valve successfully removed by traction-assisted endoscopic submucosal dissection
Authors: Simona Agazzi, Eukene Rojo, Clara Yzet, Jérôme Rivory, Louis Jean Masgnaux, Elena De Cristofaro, Mathieu Pioche
Journal: Endoscopy (2025)

The ileocecal valve (ICV) is one of the most difficult locations for endoscopic submucosal dissection (ESD) because of limited scope maneuverability, the presence of fatty tissue, and particular anatomic features [1[1]]. Consequently, the en bloc and R0 resection rates are reported to be lower than for other locations [2[2]] [3[3]]. Lesions covering ≥75% of the ICV, involvement of the anal lip or involvement of more than two sites on the ICV are reported to be risk factors for poor outcomes [4[4]]. Traction-assisted ESD has recently emerged as a technique that facilitates ESD, improving the rates of R0 resections in this challenging location [4[4]] [5[5]].
Time to focus on the potential benefit of minimally invasive treatment of remnant cystic duct stump stones
Authors: Shenggang Zhan, Defeng Li, Yanhui Tian, Ruiyue Shi, Jing Zhou, Lisheng Wang, Jun Yao
Journal: Endoscopy (2025)

Cystic duct stump stones are a well-known cause of postcholecystectomy syndrome, a term referring to the 10%–30% of patients who complain of upper abdominal pain or jaundice after a cholecystectomy [1]. Until recently, the management of stones in the cystic duct stump has been generally challenging and invasive [2] [3]. Herein, we report the minimally invasive and visually successful removal of a cystic duct stump stone using a novel peroral choledochoscope, the Eye-Max (Micro-Tech, China).
Multi-strategy endoscopic submucosal dissection of a challenging lesion
Authors: Véronique Van der Voort, Romain Legros, Jérémie Albouys, Hugo Lepetit, Timothée Wallenhorst, Mathieu Pioche, Jérémie Jacques
Journal: Endoscopy (2025)

Over the years, advancements in endoscopic submucosal dissection (ESD) have significantly refined and simplified the technique, allowing for successful endoscopic resection of increasingly complex lesions. Determining the right strategy or tool can be challenging and is not bound by strict rules – sometimes, in complex cases, you end up using every tool available.
Submucosal tunneling endoscopic resection of a rare gastric hemangioma
Authors: Ka-Kin Sze, Wai-Ming Chau, Yiu-Keung Ma, Michael Kin-Kong Li
Journal: Endoscopy (2025)

Gastric hemangioma is a rare gastric tumor, with its incidence reported to be 1.6% [1]. Gastrointestinal bleeding is one of its presenting symptoms [2]. Treatment was traditionally by surgical resection [3]. Recently, there have also been case reports of gastric hemangiomas being resected by endoscopic methods including endoscopic submucosal dissection (ESD) [4] [5]. Herein, we present a case of a gastric cavernous hemangioma being resected using submucosal tunneling endoscopic resection (STER).
Novel methods to confirm successful puncture in endoscopic ultrasound-guided hepaticogastrostomy
Authors: Haruo Miwa, Ritsuko Oishi, Shotaro Tsunoda, Yuichi Suzuki, Kazuki Endo, Hiromi Tsuchiya, Shin Maeda
Journal: Endoscopy (2025)

Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is a widely used procedure; however, it is challenging in patients with a nondilated bile duct [1]. Although, the double-wall puncture (Seldinger's method) can be helpful in such cases ([Fig. 1]), specific methods to confirm successful puncture have not been established [2] [3]. Aspiration of a large amount of bile can lead to bile duct collapse, making guidewire insertion difficult. On the other hand, if contrast agent is injected without recognizing that the puncture has failed, extravasation may occur outside of the bile duct. Herein, we demonstrate the use of two novel methods to confirm successful EUS-HGS puncture ([Video 1]).
Ectopic mediastinal parathyroid diagnosed by contrast-enhanced endoscopic ultrasound-guided fine-needle aspiration and eluate parathormone level
Authors: Matteo Parolin, Antonino Caruso, Paola Sartorato, Andrea Lisotti, Stefano Benvenuti, Ernesto De Menis, Pietro Fusaroli
Journal: Endoscopy (2025)

Primary hyperparathyroidism is defined as an elevated serum calcium with an elevated or inappropriately normal parathyroid hormone (PTH), and rarely it can be due to an ectopic mediastinal parathyroid [1].
Application of holmium laser in endoscopic retrograde cholangiopancreatographygall gallbladder-preserving cholecystolithotomy
Authors: Qian Zou, Jingfeng Du, Yaosheng Lin, Long Xu
Journal: Endoscopy (2025)

We report a case of a 59-year-old woman diagnosed with cholecystolithiasis ([Fig. 1]). She frequently experienced discomfort in the right upper abdomen after consuming greasy foods but was reluctant to undergo cholecystectomy. Consequently, she sought our assistance and requested a gallbladder-preserving cholecystolithotomy. Following thorough communication, the decision was made to proceed with endoscopic retrograde cholangiopancreatography (ERCP)-based gallbladder-preserving cholecystolithotomy.
Be cautious with the semilunar fold! Endoscopic perforation after cap-suction pseudopolyp formation for underwater en bloc resection of a big cecal lesion
Authors: Harold Benites-Goñi, Paulo Bardalez, Luis Marin, Bryan Medina, Jairo Asencios, Hugo Uchima
Journal: Endoscopy (2025)

Use of underwater endoscopic mucosal resection (UEMR) has spread worldwide since its first description in 2012 by Binmoeller [1]. In a recent randomized controlled trial, UEMR was found to be superior to EMR, with lower recurrence rates for lesions sized 20–30 mm as well as being faster and easier, but with similar safety and overall effectiveness [2].
Imaging the structural connectome with hybrid MRI-microscopy tractography
Authors: Silei Zhu, Istvan N Huszar, Michiel Cottaar, Greg Daubney, Nicole Eichert, Taylor Hanayik, Alexandre A Khrapitchev, Rogier B Mars, Jeroen Mollink, Jerome Sallet, Connor Scott, Adele Smart, Saad Jbabdi, Karla L Miller, Amy F D Howard
Journal: Medical Image Analysis (2025)