tbuckley/cabot-search huggingface dataset:
Abstract 5995: Efficacy Of The Everolimus-eluting Stent in Diabetic Patients: Comparison With The Paclitaxel-eluting Stent
Authors: Hiromasa Otake, Junya Ako, Masao Yamasaki, Ichizo Tsujino, Takao Shimohama, Takao Hasegawa, Ryota Sakurai, Katsuhisa Waseda, Paul G Yock, Yasuhiro Honda, Poornima Sood, Krishnankutty Sudhir, Gregg W Stone, Peter J Fitzgerald
Journal: Circulation (2008)

Background: In the diabetic subgroup of the Spirit III trial (randomized, multicenter trial comparing Everolimus-eluting XIENCE ™ V stent (EES) to Paclitaxel-eluting Taxus ™ stent (PES) in de novo native coronary artery lesions), PES showed a trend toward fewer major adverse cardiac event compared with EES during 1 year follow-up in patients with diabetes despite lower observed late loss with EES at 8 months. Methods: The Stanford University IVUS Core Laboratory database was queried to evaluate the efficacy of EES in diabetics compared with PES. A total of 113 lesions treated with EES (n=58) and PES (n=55) undergoing 8 or 9 months follow up 3-D intravascular ultrasound (IVUS) were enrolled. Volume index (volume/length) was calculated for vessel (VVI), peri-plaque (PVI), neointima (NIV), and lumen (LVI). %NIV was calculated as neointimal volume / stent volume × 100. Cross-sectional narrowing (CSN) was defined as neointimal area divided by stent area (%). Late lumen area loss was calculated as minimum lumen area (MLA) at post-intervention (Post) minus MLA at follow-up (FUP). Late incomplete stent apposition (LISA) was defined as separation of at least 1 strut from the vessel wall with blood speckle behind the strut, where Post IVUS revealed well apposition. Results: Average stent length was significantly longer in EES. EES showed less neointimal hyperplasia and smaller LVI loss than PES (Table ), whereas no statistical interactions were observed between EES and serial changes for VVI and PVI. PES showed a significant increase in PVI (Post: 7.6±3.1, FUP: 8.4±3.1; p=0.049) and a trend toward increase in VVI (Post: 14.8±5.5, FUP: 15.5±4.2; p=0.07) between Post and FUP. One case with LISA was observed in EES group. Conclusions: EES demonstrated significant suppression of neointimal hyperplasia in diabetic patients without vessel expansion compared with PES up to 8 months follow up. Figure 1 Intra Individual matched In-Stent Late Luminal Loss[mm]
Knowing when to say "no" on the student elective
Authors: N. Banatvala, L. Doyal
Journal: BMJ (1998)

Personal view p 1466 

The elective can be one of the most exciting components of a medical student's training. When done abroad, it sometimes offers the opportunity to experience health care in a different cultural and organisational setting and to see diseases that are rarely, if ever, encountered in Great Britain. Other benefits include the maturity that comes from medico-social understanding, self-reliance, and resourcefulness that the elective experience can provide.1 Several reports describing activities on electives provide further insight into their opportunities, challenges, and benefits.2-6

The increasingly focused medical curriculum in the UK is a key reason to promote the elective. Yet despite its advantages, some concerns remain. The author of a report of his elective alludes to the discomfort felt about suddenly being expected to “see patients” (p 1466).6 Such concerns are often no different from anxieties experienced by medical students in Great Britain. …
Abnormal Psychology and Education.
Authors: Frank Watts, Joseph Jastrow
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17248: Risk Factors for Cardiovascular Disease in Inmates
Authors: Alison Connell, Misook L Chung, Terry A Lennie, Alison Bailey, Debra Moser
Journal: Circulation (2011)

Background: In the United States 1 out of every 100 males are imprisoned with federally mandated health care provided by the prison. Inmates tend to have high tobacco, alcohol and drug use but other risk factors have not been reported. The purpose of this study was to determine if a self-rated general health question was associated with lipid levels and modifiable risk factors of inmates. Method: A total of 304 male inmates (ages 19-77; M = 36 ± 9.7) in four medium security state prisons completed the Inmate Health Risk Assessment, comprised of 10 items on tobacco use, diet, exercise, stress, social support and coping. Categorical responses were rated from 1-3 giving a possible range of 10 to 30 with lower scores indicating healthier life-styles. The general health question had a 5-point Likert scale from excellent to poor. Finger stick lipid panel was obtained for high density lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol, and triglycerides. Results: The single general health item was associated with HDL, triglyceride levels and the total cholesterol-to-HDL ratio (p &lt; 0.001) but not with total cholesterol (p = .07) or LDL (p=.32). The mean score on the IHRA was 18.3 ( SD = 3.3). Perception of poorer health on the general health question was associated with increased scores on the IHRA (p = &lt; 0.001) after controlling for age, ethnicity, marital status and education level. Conclusion: Inmates who reported a perception of poor health had more modifiable lifestyle risk factors such as tobacco use, poor coping, sedentary lifestyle, and poor nutrition than those with perceptions of good to excellent health. Perception of poor health was associated with lower HDL and higher triglyceride levels. The single general health question may be useful for prison health care providers to target behavioral interventions that can improve cardiovascular health in inmates.
Physiology and Pharmacology for Pharmaceutical Students
Authors: Harold Hayden Barber
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gemcitabine combined with oxaliplatin in advanced breast cancer: Updated results of two parallel phase II studies
Authors: P. H. Cottu, T. Caruba, M. Espié, I. Madelaine-Chambrin, J. L. Misset, M. Gross-Goupil
Journal: Journal of Clinical Oncology (2005)

839 Background: We have previously reported the results of 2 gemcitabine-oxaliplatine (gem-ox) combinations in advanced breast cancer (Proc ASCO 2003 #310; Caruba et al). We present here updated Results: Methods: Patients with previously treated metastatic breast cancer (MBC) were eligible. Prior utilisation of anthracyclins and taxanes was mandatory. Two schedules were tested. Schedule A: gem D1 and ox D2 on a q2w schedule. Schedule B: gem D1–8 and ox D1, on a q3w schedule. In each schedule, administered doses were 1000 mg/m2 for gem, and 100 mg/m2 for ox. Results: 43 patients were included, respectively 21 and 22 for schedules A and B. 31/43 pts (72%) had multisite MBC, and all pts but 1 had received at least 2 lines of chemotherapy for metastatic disease. Pts characteristics were very close for both schedules. Objective Response Rate (WHO criteria) was 7.5% in 40 pts who were evaluable for response, Stable Disease was observed in 27.5% of those pts. Median TTP was 12 weeks for all patients, and was 42 weeks for responding pts. No difference of efficacy was observed between schedules A and B. Toxicity: Respectively 123 and 111 courses were administered for schedules A and B. The only significant different toxicities between the two schedules were: Gr 3–4 anemia in 1% vs 9% of courses (p=0.003), and gr 1–2 emesis in 6% vs 17% of courses (p=0.011) for schedules A and B, respectively. Other side effects were similar: gr 3–4 neutropenia 16% of courses; gr3–4 thrombocytopenia 6%; gr 3–4 neuropathy 2%. Conclusions: Both schedules were feasible in very advanced MBC pts, with similar and very promising efficacy. The schedule A seems less toxic and should be tested in earlier disease. No significant financial relationships to disclose.
Abstract P426: Quercetin Intake Differentially Affects the Plasma Lipid Levels and Lipoproteins Associated Gene Expression in Normal C57bl Female Mice
Authors: Mahdi Garelnabi, Halleh Mahini
Journal: Circulation (2013)

Background: Quercetin is a member of the bioflavonoids family known to have antiatherogenic, antiinflammatory, and antihypertensive properties; and reported to have cardiovascular protective role. Quercetin through its antioxidant action may protect against oxidative stress induced by free radicals consequently decreasing the potential for modification of low density lipoprotein cholesterol (LDL); however it is not clear if the intake of quercetin during exercise may have beneficial effect on plasma lipids. Goals and hypothesis: We hypothesized that the intake of quercetin with exercise will affect plasma lipids. The goal of this study is to investigate the beneficial effect of Quercetin on normal female mice. Study Design and Methods: We investigated the possible beneficial effects of the combined exercise and quercetin on plasma lipids in C57BL6 normal female mice fed normal mouse chow. Mice (N=29) were divided into four groups. These groups are as follows: Control mice, left untreated; control quercetin group, orally supplied with 100 μg/day of quercetin without exercising; exercise group without quercetin, and exercise group with quercetin supplements. The exercise groups were run on a treadmill for 30 minutes, 15m/m/ 5 days/week for 30 days. At the end of the month of the treatment, mice were sacrificed liver gene expressions for genes associated with lipoprotein metabolism were analyzed, and plasma lipids levels were analyzed. Results and Discussion: Our data interestingly showed that Quercetin differentially influences the levels of lipoprotein, oxidative stress and inflammatory markers gene expression during exercise in normal female mice; however plasma lipids, specifically TG plasma levels have elevated among mice consuming quercetin alone or with exercise significantly (P&lt;0.5). Conclusion: This study have demonstrated that Quercetin intake with exercise may differentially affects the plasma lipid levels and lipoproteins associated gene expression in normal C57BL female mice.
All-trans retinoic acid normalizes the periodicity of photoaged fibrillin microfibrils in vivo
Authors: Sarah Thurstan, E C Naylor, Cem Griffiths, Rachel Eb Watson, M J Sherratt
Journal: British Journal of Dermatology (2014)

Times Cited: 0 Annual Meeting of the British-Society-of-Investigative-Dermatology Annual Meeting of the British-Society-for-Investigative-Dermatology APR 07-09, 2014 Newcastle, ENGLAND Newcastle Upon Tyne, ENGLAND British Soc Investigat Dermatol 0
A New Approach to Dietetic Therapy in Epilepsy, Eclampsia of Pregnancy and Infancy, Migraine, Angina Pectoris, Bronchial Asthma, Allergic Diseases, Gout. Essential Hypertension, Pernicious Anemia, Polycythemia, Acne Vulgaris, Nervous and Psychic Disturbances, Constitutional Changes, Aging, etc. Metabolism of Water and Minerals and Its Disturbances.
Authors: Eugene Földes
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Activity of Duvelisib (IPI-145), a Phosphoinositide-3-Kinase-δ,γ Inhibitor, in Patients Previously Treated with Ibrutinib
Authors: Pierluigi Porcu, Ian Flinn, Brad S. Kahl, Steven M. Horwitz, Yasuhiro Oki, John C. Byrd, Jennifer Sweeney, Kerstin Allen, Kerrie Faia, Min Ni, Howard M. Stern, Patrick Kelly, Susan O'Brien
Journal: Blood (2014)
The Evolution of Modern Medicine.
Authors: William Osler
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2686: Can Real-Time 3D Echocardiography Be Used to Assess Myocardial Perfusion?
Authors: Amit Bhan, Stamatis Kapetanakis, Bushra S Rana, Emily Ho, Karen Wilson, Mark J Monaghan
Journal: Circulation (2007)

Introduction: 2D low mechanical index (LMI) contrast specific myocardial perfusion imaging is now an accepted technique. Advancements in technology now allow us to use this technique in combination with real-time 3D echo. We assessed the hypothesis that real time 3D myocardial contrast echo (RT3DMCE) is feasible in a clinical setting. Methods: 46 consecutive patients (24 male) referred for contrast enhanced echocardiography were imaged using a 3D scanner equipped with novel 3D LMI power modulation software. All patients underwent 2D contrast echo and real-time 3D apical full volume acquisition, during contrast infusion. Datasets were taken in left ventricular opacification (LVO) and LMI perfusion modes. These were then evaluated segmentally for wall motion and myocardial contrast enhancement, relative to the LVO mode. Results: A total of 736 left ventricular segments were analysed. Wall motion and perfusion could be assessed in 726 (98.6%) and 721(98%) respectively of the 2D segments and 708 (96.2%) and 701(95.2%) of the 3D segments. Although p=&lt;0.05 for these comparisons, they showed good agreement: 97.6% ( kappa 0.52) for wall motion and 97.3% ( kappa 0.61) for perfusion. 661 segments had normal wall motion and thickening in 2D. Of these, normal 3D myocardial opacification was seen in 91.8% of apical, 85% of mid and 77.2% of basal segments. 34 segments were akinetic with no 2D evidence of perfusion and of these RT3DMCE successfully identified a perfusion defect in 31 (91% p=NS). Conclusion: Evaluation of myocardial perfusion using RT3DMCE is feasible in most segments. In the future it has the potential to specify accurate location of perfusion defects and quantify volumes.
A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy
Authors: Julien Valton, Valérie Guyot, Alan Marechal, Jean-Marie Filhol, Alexandre Juillerat, Aymeric Duclert, Philippe Duchateau, Laurent Poirot
Journal: Molecular Therapy (2015)

The adoptive transfer of chimeric antigen receptor (CAR) T cell represents a highly promising strategy to fight against multiple cancers. The clinical outcome of such therapies is intimately linked to the ability of effector cells to engraft, proliferate, and specifically kill tumor cells within patients. When allogeneic CAR T-cell infusion is considered, host versus graft and graft versus host reactions must be avoided to prevent rejection of adoptively transferred cells, host tissue damages and to elicit significant antitumoral outcome. This work proposes to address these three requirements through the development of multidrug-resistant T cell receptor αβ-deficient CAR T cells. We demonstrate that these engineered T cells displayed efficient antitumor activity and proliferated in the presence of purine and pyrimidine nucleoside analogues, currently used in clinic as preconditioning lymphodepleting regimens. The absence of TCRαβ at their cell surface along with their purine nucleotide analogues-resistance properties could prevent their alloreactivity and enable them to resist to lymphodepleting regimens that may be required to avoid their ablation via HvG reaction. By providing a basic framework to develop a universal T cell compatible with allogeneic adoptive transfer, this work is laying the foundation stone of the large-scale utilization of CAR T-cell immunotherapies.
StemEx®(Copper Chelation Based) Ex Vivo Expanded Umbilical Cord Blood Stem Cell Transplantation (UCBT) Accelerates Engraftment and Improves 100 Day Survival In Myeloablated Patients Compared To a Registry Cohort Undergoing Double Unit UCBT: Results Of a Multicenter Study Of 101 Patients With Hematologic Malignancies
Authors: Patrick J Stiff, Pau Montesinos, Tony Peled, Efrat Landau, Noga Rosenheimer, Julie Mandel, Nira Hasson, Esti Olesinski, Ela Glukhman, David A. Snyder, Einat Galamidi Cohen, Orna Srur Kidron, Dalia Bracha, Dorit Harati, Keren Ben-Abu, Etty Freind, Laurence Freedman, Yael C Cohen, Liraz Olmer, Raya Barishev, Vanderson Rocha, Mary M. Horowitz, Mary Eapen, Arnon Nagler, Guillermo Sanz
Journal: Blood (2013)
Chemical Treatment of Tumors. VI. Method Employed in Determining the Potency of Hemorrhage-Producing Bacterial Preparations
Authors: M J Shear, Perrault Adrien, R Adams John
Journal: JNCI Journal of the National Cancer Institute (1943)

Journal Article Chemical Treatment of Tumors. VI. Method Employed in Determining the Potency of Hemorrhage-Producing Bacterial Preparations Get access M. J. Shear, M. J. Shear principal biochemist Search for other works by this author on: Oxford Academic PubMed Google Scholar Adrien Perrault, Adrien Perrault scientific aide Search for other works by this author on: Oxford Academic PubMed Google Scholar John R. Adams, Jr. John R. Adams, Jr. assistant chemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 4, Issue 1, August 1943, Pages 99–105, https://doi.org/10.1093/jnci/4.1.99 Published: 01 August 1943
COMMERCIAL TRAFFIC: ITS ESTIMATED DAMAGING EFFECT, 1945-2005
Authors: Ewh Currer, Mgd O'connor
Journal: BMJ (1979)

The laboratory has developed a weighbridge system that records automatically, without interference with the traffic, the magnitude of wheel loads passing over it. The report summarises the results obtained from 30 weighbridges installed, primarily for the purposes of research, at a number of full-scale road experiments and on three motorways. Systematic data have been obtained from some of the more important sites; at others it has proved possible to make only infrequent measurements. Since 1973 the weights, and hence the damage factor, of axles of the commercial traffic using motorways and some heavily trafficked trunk roads have risen considerably faster than on other roads. Traffic on the exit road from a refinery and port has shown to have a greater axle damage factor than any measured motorway traffic. Estimates have been made of the number of axles and the damage factor of the average commercial vehicle using different categories of road. The results have then been combined to give curves for estimating the changes in vehicle damage factor of commercial vehicles on four categories of road between the years 1945 and 2005. Tables are presented of the factors required for the design of a new road, for the prediction of the remaining life of an existing road and for the design of strengthening measures for such a road. (Author/TRRL)
"PLAIN WORDS ABOUT VENEREAL DISEASE"
Authors: Thomas Parran, R. A. Vonderlehr
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal