tbuckley/cabot-search huggingface dataset:
A phase I/II study to determine the feasibility and efficacy of the triple combination of oblimersen (OBL), abraxane (ABX), and temozolomide (TMZ) in metastatic melanoma and normal LDH
Authors: A. C. Pavlick, J. Escalon, K. Madden, E. Yepes, J. Staha, T. Ryan, M. T. Buckley, S. Mendoza, H. Yee, L. F. Liebes
Journal: Journal of Clinical Oncology (2008)

9027 Background: OBL plus dacarbazine was significantly more efficacious than dacarbazine alone in patients with advanced melanoma (Bedikian et al, JCO, 2006). The OBL-dacarbazine regimen provided maximum benefit in patients with normal baseline LDH based on all endpoints, including survival (median, 11.4 vs. 9.7 months [p=0.018]). TMZ is an orally administered chemotherapy with a mechanism of action and efficacy in melanoma similar to that of dacarbazine (Middleton et al, JCO, 2000). ABX (albumin-bound paclitaxel) is currently being explored in melanoma (Hersh et al, JCO, 2005) An OBL-TMZ-ABX combination was synergistic preclinically, and a Phase I/II study of this combination initiated. Methods: Eligible are chemotherapy-naive patients with advanced melanoma, baseline LDH ≤1.1 x ULN, and measurable disease (RECIST). Treatment includes OBL 7 mg/kg/d (continuous IV infusion, days 1–7 and 22–29), TMZ 75 mg/m2/d (days 1–42), and ABX 175 mg/m2 (days 7 and 29) in Cohort 1 and 260 mg/m2 in Cohort 2 for four 56-day cycles. Serial serum samples are obtained for OBL and ABX pharmacokinetics. Pre- and post-tumor biopsies and PBMCs are monitored for Bcl-2 and proliferation markers and correlated with clinical response. Results: All 14 (1-M1a, 5-M1b, 8-M1c) patients planned for Cohort 1 have been enrolled; treatment is ongoing in 10. Grade 3–4 adverse events have been limited to 1 pt with neutropenia and 1 pt with thrombocytopenia. Four patients have achieved a partial response (>50% tumor reduction) lasting > 2 cycles (range: 3–6 cycles); 2 stable disease lasting 3 cycles; and 2 PD after 1 cycle. In 6, it is too early to assess response. IHC markers show a significant reduction in Bcl-2, a proportional increase in Bak and BCLxl, and no change in caspase activity. OBL and TMZ have no effect on ABX pharmacokinetics. Shed cryptic epitopes measured serially correlate with clinical responses. Conclusions: Tumor and serologic assessment of biomarkers correlate with clinical and radiologic responses or progression. Prolonged clinical activity has been seen and the regimen is safe and well tolerated. Cohort 2 is open to enrollment. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Genta Genta Abraxis, Genta
THE EFFECT OF X-RADIATION ON THE OXYGEN UPTAKE OF EMBRYONATE EGGS
Authors: Donald Greiff, Herman T. Blumenthal, Masahiro Chiga, Henry Pinkerton
Journal: The Journal of Experimental Medicine (1953)

Groups of 10 day old embryonate eggs were given 250, 500, 750, and 1000 r of x-radiation, and oxygen consumption determinations were made subsequently at various intervals during a period of 90 hours. In general, the effect of radiation was moderately stimulatory, but after 90 hours the respiratory rates of the 250 and 1000 r groups were well below those of the control groups. The most striking effect, noted in 3 separate experiments, was the occurrence of a "3 step staircase" type of oxygen consumption curve in all irradiated groups, the levelling off periods apparently occurring between the 4th and 14th, the 24th and 36th, and the 42nd and 66th hours after exposure. These curves were in striking contrast to those shown by groups of non-irradiated eggs, which were practically of the straight line type.
Troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non–insulin dependent diabetes mellitus
Authors: Tsutomu Takagi, Takashi Akasaka, Atsushi Yamamuro, Yasuhiro Honda, Takeshi Hozumi, Shigefumi Morioka, Kiyoshi Yoshida
Journal: Journal of the American College of Cardiology (2000)
Abstract P162: Lifestyle Intervention Improves Global Cardiovascular Health in Latinos with Prediabetes in Maracaibo, Venezuela
Authors: Hermes J Florez, Victoria Stepenka, Sumaya Castillo-Florez, Yoleida Rivas, Juan Casal, Elena Ryder, Egle Silva, Gladys Maestre, Lisset Oropesa
Journal: Circulation (2012)

Introduction: The epidemics of obesity and hyperglycemia are associated with increased cardiovascular (CV) disease. There are limited data on the CV benefits of evidence-based lifestyle intervention strategies in developing countries. Aim: To assess impact o lifestyle intervention strategies based on the US Diabetes Prevention Program (DPP) on the global cardiovascular health. Methods: In a pilot clinical trial 140 Latino subjects (63.6% women) with prediabetes (ADA guidelines) were randomly assigned to receive either standard of care (SC, n=70) or group lifestyle (LS, n=70) intervention for 2 years in the healthcare system of Maracaibo, Venezuela. Ideal CV health behaviors (nonsmoking, achieving normal weight, enough physical activity, and a healthy diet) and ideal CV health factors (total cholesterol&lt;200 mg/dl, blood pressure&lt; 120/80 mmHg, and fasting blood glucose&lt;100 mg/dl) were evaluated at baseline and every 6 months. We calculated the American Heart Association (AHA) global CV health score assigning 1 to each ideal behavior and factor (for a maximum of 7) and 0 for poor status to each one. Results: Subjects were aged 48.1±11.8 years, had a BMI of 32.1±5.5kg/m² and a baseline score CV of 3.9 ±0.1 (i.e., 84.3% in SC and 88.6% in LS had poor to intermediate CV score). Larger improvements in the CV scores from baseline were obtained in the LS vs. SC (p&lt;0.0001) after 6 months (1.7±0.8 vs. 0.6±0.7), 12 months 2.3 ±0.8 vs. 1.2±0.8), 18 months (1.9±0.9 vs. 0.8±0.6) and 24 months (2.0±0.9 vs. 0.8±0.6) of intervention. At study end only 4.3% of LS and 47.1% of SC participants had poor-intermediate CV score (p&lt;0.01). Conclusions: Implementation of DPP- based lifestyle intervention leads to moderate improvements in overall CV health among Latinos with prediabetes in Venezuela. Achievement of the proposed 2020 AHA goal for better CV health seems feasible in this high-risk Latino population.
Airborne Particulate Matter and Acute Lung Inflammation: Strak et al. Respond
Authors: Maciej Strak, Nicole A.H. Janssen, Ilse Gosens, Flemming R. Cassee, Erik Lebret, Krystal J. Godri, Ian S. Mudway, Frank J. Kelly, Roy M. Harrison, Bert Brunekreef, Maaike Steenhof, Gerard Hoek
Journal: Environmental Health Perspectives (2013)
Interferons: Their Impact in Biology and Medicine.
Authors: Joyce Taylor-Papadimitriou
Journal: Annals of Internal Medicine (1986)

It is just over a quarter of a century since Isaacs and Lindenman described the interferons (IFN)?a group of proteins produced by cells in response to virus infection.This concept was not immediately accepted, some critics even suggesting that the material found should really be called 'misinterpreton'.However, the skilled work of Isaacs and his colleagues has established beyond doubt
Abstract 2644: High Prevalence of a Novel Conduction Pattern Around the Coronary Sinus in Cavotricuspid Isthmus Dependent Right Atrial Flutter
Authors: yoshio yamaguchi, Hiroichi Tsugawa, Nakaba Fujioka, Ken-ichi Kaseno, Michihiko Kitayama, Kouji kajinami
Journal: Circulation (2007)

Objective : We tested our hypothesis that, in atrial flutter (AFL) dependent on the cavotricuspid isthmus (CTI), lower loop reentry (LLR) is the common pathway route at the coronary sinus (CS) posterior site, and thus, dual loop reentry (DLR) is a common circular pattern. Methods and result s: We studied 25 patients with CTI-dependent AFL, 16 with chronic counterclockwise atrial flutter (CCW-AFL) and 9 with clockwise atrial flutter (CW-AFL) and determined the precise reentry circuitry, especially for conduction patterns around the CS orifice, using electroanatomical mapping. We measured post pacing interval and tachycardia cycle length during entrainment from sites within the flutter circuit. In 16 of the 25 CCW-AFL patients, the CS anterior pacing site was within the AFL circuit in 13. The CS anterior pacing site was within the AFL circuit in 6 of the 9 CW-AFL patients. In 8 each of 16 CCW-AFL and 9 CW-AFL patients, both the CS anterior and posterior sites were within the AFL circuit. Results of 3-Dimensional (3D) activation mapping suggest that all of these patients had a DLR circuit, and that CS posterior conduction broke through the eustachian valve/ridge. Conclusion : CS posterior conduction consisted of the flutter circuit and appeared to be critical for maintaining AFL. Almost all AFL patients had DLR formed within the LLR or the superior RA circuit constituted from CS posterior conduction and in the anterior loop around the tricuspid annulus.
Margaret McCartney: Time to give patients informed choice
Authors: M. McCartney
Journal: BMJ (2015)

Time is short: 10 minutes. Come in, take a seat, make introductions. Remove a jacket. Say what’s wrong. Talk freely. I ask questions to exclude or include a diagnosis. We may need a translator, who may or may not have been organised. On average, we discuss two or three problems.

Then an examination, which may require undressing, a chaperone, screens pulled around. We discuss findings, uncertainties, a proposed course of (in)action, and decisions (perhaps to defer a decision). My computer prompts me to review drugs, ask about smoking, and switch drugs to cheaper varieties. A few words may reveal why the patient is here at all. We may discuss follow-up and whether I can leave voicemail messages. Then re-dressing, leaving, …
Abstract 12290: The African-American Single Nucleotide Polymorphism (snp) Rs34423165 in Ldb3 Alters Kv7.1 in Familial Dcm with Qt-Prolongation
Authors: Yutao Xi, Tomohiko Ai, Bhagyalaxmi Mohapatra, Geru Wu, Haider S Alwash, Junping Sun, Ross T Murphy, Shaughan Dickie, William McKenna, Jeffrey A Towbin, Jie Cheng, Matteo Vatta
Journal: Circulation (2011)

Background: Genetic mutations in the LDB3-encoding the Z-band alternatively spliced PDZ motif-containing protein (ZASP) cause cardiomyopathy associated with arrhythmias and sudden cardiac death (SC...
Cerebral Radionuclide Angiography.
Authors: Frank H. DeLand
Journal: Annals of Internal Medicine (1977)

This atlas of radionuclide  studies of the brain comes at a time when CT scanning has replaced radionuclide studies as the primary means of investigating clinically suspected brain disease. It emphasizes those things done best by radionuclides, such as noninvasive and relatively quantitative evaluation of rapidly changing physiological processes. Providing a brief but sound anatomical, physiological, and technical basis for these studies, the atlas delves into a detailed, well-selected case analysis of common clinical categories of trauma, neoplasms, congenital diseases (limited to a few vascular anomalies), vascular diseases, and computer applications. Careful study of each case is necessary to extract the maximum information. There is a great deal of correlative emphasis with electroencephalography and cerebral angiography. As in any such ambitious undertaking, there are points with which one may disagree. I found the embryology section of value for pointing out, but not remedying, my deficiencies. In a number of cases, as is all too common in our daily practice, we are left hanging without definite proof; in one instance of acute changes in a diabetic, even postmortem examination does not explain the scan findings. The references to aneurysms predate the frequent use of angiography, making this portion of the text obsolete. Although reproductions of the radionuclide studies are excellent, the angiograms suffer by comparison. Almost all of the dynamic studies are vertex views, which require much technical care in proper execution and are rarely used in most institutions, although Dr. Deland's results suggest that more widespread use would make the extra trouble worthwhile. The author's results with this technique in studying vascular disease, demonstrating abnormal perfusion studies in more than 90 % of patients with strokes involving the cerebral cortex, need to be substantiated by other groups. The section on computer applications demonstrates succinctly and understandably the promise of superiority which could be provided by quantitative methods. This is a superb atlas: informative, readable, and complete. All physicians who deal with neurological disease, including the general radiologist and angiographer, should be familiar with this book so that their patients may benefit. It should be in the library of all nuclear medicine specialists who perform cerebral radionuclide angiography.
MYCOTIC ANEURYSM: REPORT OF A CASE
Authors: J. P. Eichhorn, Curtis F. Garvin
Journal: Annals of Internal Medicine (1943)

Case Reports1 August 1943MYCOTIC ANEURYSM: REPORT OF A CASEJ. P. EICHHORN, M.D., CURTIS F. GARVIN, M.D.J. P. EICHHORN, M.D.Search for more papers by this author, CURTIS F. GARVIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-2-347 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVirchow1 in 1847 described arterial dilatation developing at the site of embolism, and subsequently the rôle of embolism in the production of certain aneurysms came to be generally recognized. The term "mycotic" was adopted to call attention to the etiologic importance of infection. The term is somewhat misleading since a special group of infections has come to be called the mycoses, but it is sanctioned by long and general use.Mycotic aneurysms are comparatively rare. Any artery may be involved, the aorta most frequently. Mycotic aneurysms usually occur in association with endocarditis lenta. The pathogenesis of the condition may be...Bibliography1. VIRCHOW VR: Ueber die akute Entzündung der Arterien, Virchow's Arch. f. path. Anat., 1847, i, 272-378. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Received for publication June 14, 1941.From the Department of Medicine of Cleveland City Hospital and the School of Medicine of Western Reserve University. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLeft ventricular aneurysm of unusual aetiology: report of two cases. 1 August 1943Volume 19, Issue 2Page: 347-349KeywordsAneurysmsAortaArteriesEndocarditisHospital medicineMycosesPathogenesis ePublished: 1 December 2008 Issue Published: 1 August 1943 PDF downloadLoading ...
Allogeneic Hematopoietic Stem Cell Transplantation for Therapy-Related Acute Myeloid Leukemia
Authors: Mauricette Michallet, Mohamad Sobh, Jeremy Monfray, Hélène Labussière-Wallet, Sandrine Hayette, Isabelle Tigaud, Mohamed Elhamri, Lila Gilis, Laure L Lebras, Fiorenza Barraco, Sophie Ducastelle, Valerie Dubois, Franck E. Nicolini, Xavier Thomas
Journal: Blood (2014)
Principles of Surgical Research
Authors: Robert T. Mathie, K. M. Taylor
Journal: Annals of Internal Medicine (1990)

Section 1: Designing and starting a research project. Philosophy of science: implications for medicine and surgery Handling the original idea Experimental models Statistical aspects of research study design Information management Applying for a research grant Section 2: Conducting a research project. The role of the ethics committee The controlled clinical trial Research in a district general hospital Use of animals in surgical research An introduction to molecular biology in surgical research Section 3: Computers and statistics. Computer jargon Computer databases Descriptive statistics and graphical presentation Statistical analysis and interpretation Section 4: How to do it. Presenting a paper at a scientific meeting Writing a paper for publication Illustrating presentations and publications Writing and submitting a thesis.
Abstract 2095: Health Policy: Can an Open Access Model for Intravenous Diuretics in an Outpatient Heart Failure Disease Management Program Reduce Hospital Costs?
Authors: Dylan L Steen, Valerie Reed, Gwendolyn Roxas, Maria Fonseca, Barbara Lopez, Kathy Hebert
Journal: Circulation (2008)

Background: Heart failure (HF) is the most frequent discharge diagnosis for patients older than 65 and one of the most expensive diseases to treat for CMS. Patients with early symptoms of decompensated HF may need access to IV diuretics when oral medications used in a sliding scale dosage are no longer effective. Indigent patients without access to a private physician are at particular risk of having to use the emergency room (ER) for this reason. This model results in more costs and potential admissions. We sought to reduce ER use and improve quality of care and service to indigent patients followed in a Heart Failure Disease Management Program (HFDMP). Methods: Grant funding was procured to provide free furosemide IVP, potassium and metolazone for patients enrolled in a HFDMP at Jackson Memorial Hospital. The HFDM program consist of intense patient education using DVD’s in both English and Spanish, written material, log books for weight, activity, blood pressure and diuretic use. Patients are instructed to weight daily and add an additional oral dose of furosemide at home for weight gain of greater than 2 pounds. For weight gain of greater than 5 pounds unresponsive to oral therapy, patients were given access to the clinic without an appointment for “walk-in” IVP furosemide, potassium and metolazone. Results: 173 new patients were enrolled into program in 3 months (10/07 through 12/31/07). Of these, 115 visits for IVP furosemide were recorded from 54 patients. 16 patients used it multiple times (range 2–11). Average ER cost for all CHF patient seen and discharged after diuresis at JMH is $25,692. Therefore, an estimated cost savings of 115 avoidable ER visits is $2,954,586. In the last three quarters of 2007, of all CHF patients seen in the ER, 96.6% are admitted. The average inpatient cost for a primary diagnosis of CHF was $26,404.05 (LOS 5.25 days). The average for a CHF patient seen and discharged from the ER was $5,295 (LOS &lt;48hrs). All monetary values are Billed Charges. Conclusion: An open access IVP furosemide program is cost effective alternative to ER and inpatient treatment for CHF patients requiring diuresis.
Development of Cerebral Cortex
Authors: G Bock, Zoltan Molnar
Journal: BMJ (1948)

Partial table of contents: Cell Lineage and Patterns of Migration in the Developing Cortex (C. Walsh and C Reid). The Cell Lineage of Neuronal Subtypes in the Mammalian Cerebral Cortex (J. Parnavelas, et al.). Factors Regulating the Differentiation of Neural Precursors in the Forebrain (P. Bartlett, et al.). Subplate Neurons and the Patterning of Thalamocortical Connections (A. Ghosh). Plasticity in the Development of Neocortical Areas (D. O'Leary, et al.). Factors that are Critical for Plasticity in the Visual Cortex (N. Daw, et al.). Cortical Development and Neuropsychiatric Disorders (G. Roberts, et al.). Indexes.
Aging and Ethics: Philosophical Problems in Gerontology
Authors: Nancy Ann Silbergeld Jecker
Journal: Annals of Internal Medicine (1992)

Introduction. The Aging Individual. The Meaning of Life. The Meaning of Life and the Meaning of Old Age. Oedipus and the Meaning of Aging: Personal Reflections and Historical Perspectives. Recovering the Body in Aging. Aging and Filial Responsibility. The Aging Society as a Context of Family Life. What Do Grown Children Owe Their Parents? Families as Caregivers: The Limits of Morality. Health Care Decision Making. Rethinking Family Loyalties. The Role of Intimate Others in Medical Decision Making. Distributive Justice in an Aging Society. Limiting Health Care for the Old. A Lifespan Approach to Health Care. Old Age and the Rationing of Scarce Health Care Resources. Appeals to Nature in Theories of Age Group Justice. Paying the Real Costs of Lifesaving. Intent and Actuality. Philosophical Reflections on Aging and Death. Resentment and the Rights of the Elderly. Ancient Myth and Modern Medicine: Lessons from Baucis and Philemon. The Meaning of Temporality in Old Age. The Absurd. Index.
Minimal Residual Disease Detection By Next Generation Sequencing in Adult B-Cell Acute Lymphoblastic Leukemia (ALL) Patients Treated on SWOG Trial S0333
Authors: Olga Sala Torra, Megan Othus, David W Williamson, Brent L. Wood, Ilan Kirsch, Harlan Robins, Margaret O'Donnell, Stephen J. Forman, Frederick R. Appelbaum, Jerald P Radich
Journal: Blood (2014)
Sang et organes hémopoïétiques
Authors: Albert Touraine
Journal: JAMA (1935)

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Pomalidomide In MPN–associated Myelofibrosis With Cytopenia: Results Of The Mpnsg 01-09 Study
Authors: Richard F. Schlenk, Frank Stegelmann, Andreas Reiter, Edgar Jost, Norbert Gattermann, Holger Hebart, Cornelius F. Waller, Andreas Hochhaus, Uwe Platzbecker, Philippe Schafhausen, Igor W. Blau, Walter Verbeek, Florian H Heidel, Martin Werner, Hans Kreipe, Cora Heiligensetzer, Silja Mack, Sabine Ostlender, Veronica Teleanu, Axel Benner, Hartmut Döhner, Martin Grießhammer, Konstanze Döhner
Journal: Blood (2013)
Radiologic Examination of the Small Intestine.
Authors: Ross Golden
Journal: Annals of Internal Medicine (1945)

The author introduces this subject with a brief outline of the indications for a radiologic study of the small intestine, a description of his method for carrying out this detailed study and discussion of the use of the small intestinal enema (Schatzki). There follows an account of the known facts of developmental anatomy of the small intestine graphically clarified by four excellent diagrammatic drawings of the stages of rotation of the intestine. He then describes the gross and microscopic anatomy of the small intestine, following with a clear presentation of the present knowledge of the physiology of the various components of the intestinal wall, including a discussion of the intrinsic nervous plexuses, the muscularis mucosae and the chemical mediator theory of the neuromuscular and neuroepithelial mechanism of the intestine. A chapter is devoted to the normal radiologic appearances of the adult small intestine from the standpoint of motility and mucosal
Clinical Features and Outcome Of Clonal Mastocytosis Secondary To Chronic Myelomonocytic Leukemia (SM- AHNMD/CMML) Given Diverse Therapies – A Single Institution Retrospective Study
Authors: Prerna Rastogi, Lynn C. Moscinski, Rami S. Komrokji, Eric Padron, Elizabeth M. Sagatys, Mojdeh Naghashpour, Jiangchuan Tao, John M. Bennett, Alan List, Jeffrey E Lancet, Kenneth S. Zuckerman, Ling Zhang
Journal: Blood (2013)