tbuckley/cabot-search huggingface dataset:
Abstract 3035: Sirolimus-eluting Stents Compared With Bare Metal Stents or Coronary Artery Bypass Grafting in Patients with Multivessel Disease including Involvement of the Proximal Left Anterior Descending Artery: Analysis of the Arterial Revascularization Therapies Study part 2 (ARTS-II)
Authors: Neville Kukreja, Patrick Serruys, Bernard de Bruyne, Antonio Colombo, Carlos Macaya, Gert Richardt, Jean Fajadet, Christian Hamm, Monique Schuijer, Magdaleen Pieters, Hans-Peter Stoll
Journal: Circulation (2008)

Objectives: Although Coronary Artery Bypass Grafting (CABG) has been the historical gold standard treatment for patients with multivessel disease, the ARTS-II trial found no differences in survival or overall adverse events between sirolimus-eluting stents (SES) and the surgical arm of ARTS-I. Nevertheless, previous data have suggested that patients with disease of the proximal left anterior descending artery (pLAD) may derive particular benefit from CABG. We therefore investigated the 3-year clinical outcomes in all patients in ARTS-I and ARTS-II with pLAD (AHA segment 6) involvement. Methods: Patients in ARTS-II with disease of the pLAD (289/607, 48%) were compared with 187/600 (31%) bare metal stent (BMS) patients (ARTS-I PCI) and 206/605 (34%) surgical patients (ARTS-I CABG) with pLAD involvement from ARTS-I. The primary endpoint was the incidence of major adverse cardiac and cerebrovascular events (MACCE). Secondary endpoints included all-cause mortality, the composite of death, stroke or myocardial infarction and the need for repeat revascularization. Findings: Complete 3-year follow-up was available for 99.6% of patients in ARTS-I and ARTS-II. The ARTS-II pLAD subgroup had better survival than both ARTS-I subgroups (ARTS-II 98.6% vs. ARTS-I PCI 95.7%, p = 0.048 and vs. ARTS-I CABG 94.7%, p = 0.01) and lower rates of the hard clinical composite endpoint of death or nonfatal myocardial infarction (ARTS-II 3.1% vs. ARTS-I PCI 9.6%, p = 0.002 and vs. ARTS-I CABG 9.7%, p = 0.002). Although the ARTS-I CABG patients had a lower need for repeat revascularization than ARTS-II (5.5% vs. 13.3%, p = 0.005), the overall composite adverse event rates (death, myocardial infarction, stroke or any repeat revascularization) were not significantly different between the ARTS-I CABG and ARTS-II patients (15.1% vs. 18.1%, p = 0.4). After 1 year, the SES patients had a reduction in the composite endpoint of death/CVA/MI (vs. ARTS-I PCI RR 0.27, 95% CI 0.11– 0.63 and vs. ARTS-I CABG RR 0.31, 95% CI 0.13– 0.74), although this was not statistically significant after 3 years. Conclusion: In this historical, non-randomized evaluation, SES had favorable outcomes compared to CABG or BMS in patients with multivessel coronary disease including involvement of the pLAD.
Abstract 10285: A Nanomedicine Approach to Restenosis promoting endothelial healing with Targeted Delivery of a New Lipase-labile, Myc-Max Antagonist Prodrug
Authors: Tillmann Cyrus, Dipanjan Pan, Xiaoxia Yang, Michael J Scott, Ann H Schmieder, Samuel A Wickline, Gregory M Lanza
Journal: Circulation (2011)

C-Myc, a transcription factor, is increased in vascular smooth muscle cells following vascular injury. Anti-sense oligonucleotides (AS-ODN) have been shown to inhibit c-Myc and reduce stenosis in a...
Pilocarpine: better than a scan
Authors: Fion D Bremner
Journal: BMJ (2008)

Williams et al describe a patient with a fixed dilated pupil after using a prescription hand cream with antimuscarinic properties.1

I was recently referred a 34 year old man admitted for investigation of an asymptomatic fixed dilated left pupil. The pupil abnormality was spotted by an observant staff nurse on the paediatric ward where he was visiting his daughter. He …
Tuberculosis in Officers of the Regular Army
Authors: A. T. Cooper
Journal: Annals of Internal Medicine (1933)

Article1 March 1933Tuberculosis in Officers of the Regular ArmyA. T. COOPER, M.C.A. T. COOPER, M.C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-9-1200 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis study of officers of the United States Army who have been under treatment for pulmonary tuberculosis at Fitzsimons General Hospital since January 1923 was undertaken in order to assist in arriving at an opinion of the results obtained by treatment of pulmonary tuberculosis in officers on the active list of the United States Army. All too frequently it is the usual opinion throughout the Army that when any officer contracts tuberculosis his days of usefulness for the Army are to a large extent over. Those of us who have been following the officers unfortunate enough to develop chronic pulmonary... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Fort Myer, Virginia*Received for publication March 3, 1932.†From the Medical Service, Fitzsimons General Hospital, Denver, Colorado. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1933Volume 6, Issue 9Page: 1200-1206KeywordsMedical services ePublished: 1 December 2008 Issue Published: 1 March 1933 PDF downloadLoading ...
Deprivation and emergency admissions for cancers
Authors: J. Mindell, C J Twelves, C S Thomson, J A Dewar
Journal: BMJ (1999)

Editor—The reasons for Pollock and Vickers’s findings about the relation between deprivation and emergency admissions for cancers remain speculative.1 To impute the differences in care to failures of primary care seems unfair at this stage. The authors discuss a range of possible explanations, but many other could also be relevant.

Day case treatment may require a certain level of facilities at home that are less commonly available in deprived areas. The presence of another adult at home may also be a prerequisite. Single people may be more likely to live in deprived areas; patients from deprived areas may be more likely to have a working partner who cannot afford to take time off work or who has a job where such absences would be unacceptable.

Patients with lung cancer due to smoking (more common in areas where smoking is more prevalent) may be less likely to have an operable malignancy because of concomitant disease related to smoking. The authors mention this in their discussion, but limiting the study to inpatient finished consultant episodes with a primary diagnosis of any of the three cancers of interest does not give any information about comorbidity.

I hope further research will be carried out to help elucidate the reasons behind the apparently inequitable access and treatment decisions that Pollock and Vickers have found. Both qualitative and quantitative research methods could be used to study patients’ and professionals’ experiences as patients pass through the system. Perhaps allocation of blame should wait until such results are available.
The Profession and the Public
Authors: George Edward Follansbee
Journal: Annals of Internal Medicine (1931)

Article1 August 1931The Profession and the PublicGEORGE EDWARD FOLLANSBEE, M.D.GEORGE EDWARD FOLLANSBEE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-2-224 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere are two points of view from which to look at medical economics, that of the profession and that of the public. The standpoint of the members of the medical profession has been consistently occupying the pages of state and other medical journals for years. The complaints and arguments of the doctors have been reiterated until you are familar with them. The public has had its hearing in many popular magazines and weeklies and in the newspapers. The public never sees the medical journals presenting the complaints of the profession and few of the profession read any large proportion of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Read at the Baltimore Meeting of the American College of Physicians, March 24, 1931.**Chairman Judicial Council, American Medical Association; Member Executive Committee, The Committee on the Costs of Medical Care. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1931Volume 5, Issue 2Page: 224-230KeywordsHearing ePublished: 1 December 2008 Issue Published: 1 August 1931 PDF downloadLoading ...
USE OF ESTROGENS IN MEDICINE
Authors: E L SEVRINGHAUS
Journal: Annals of Internal Medicine (1948)

Article1 October 1948USE OF ESTROGENS IN MEDICINEELMER L. SEVRINGHAUS, M.D., F.A.C.P.ELMER L. SEVRINGHAUS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-4-595 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEstrogens are substances which will provoke in numerous animal species the changes in tissues and in behavior which are known as estrus. Several steroids found in the adult female fit such a definition, the most potent being estradiol, from the metabolism of which are derived estrone and estriol. A variety of synthetic substances, not steroids, show similar estrogenic activities. The most widely known is diethylstilbestrol, and perhaps the most potent is dienestrol. Two great advantages of these synthetic compounds are their relatively lower cost and their slight loss of effectiveness when they are administered orally rather than parenterally. The disadvantage...Bibliography1. SMITHSMITH GVOW: Internal secretions and toxemia of late pregnancy, Physiol. Rev., 1948, xxviii, 1-22. CrossrefGoogle Scholar2. CAMPBELLLENDRUMSEVRINGHAUS REFCEL: Endometrial histology and pathology as revealed by the biopsy method, Surg., Gynec. and Obst., 1936, lxiii, 724-731. Google Scholar3. SHORR E: A new technic for staining vaginal smears. III. A single differential stain, Science, 1941, xciv, 545. CrossrefGoogle Scholar4. DEL CASTILLOARGONZGALLI MAININI EBJC: Cytological cycle of the urinary sediment and its parallelism with the vaginal cycle, Jr. Clin. Endocrin., 1948, viii, 76-87. CrossrefGoogle Scholar5. ALBRIGHTSMITHRICHARDSON FPHAM: Postmenopausal osteoporosis: clinical features, Jr. Am. Med. Assoc., 1941, cxvi, 2465-2474. ALBRIGHT, F.: Osteoporosis, Ann. Int. Med., 1947, xxvii, 861-882. CrossrefGoogle Scholar6. HAUSGOLDZIEHERHAMBLEN LWJWEC: Dysmenorrhea and ovulation: correlation of the effect of estrogen therapy on pain, the endometrium, and the basal body temperature, Am. Jr. Obst. and Gynec., 1947, liv, 820-828. CrossrefGoogle Scholar7. INGLE DJ: Diabetogenic effect of stilbestrol in force-fed normal and partially depancreatized rats, Endocrinology, 1941, xxix, 838-848. CrossrefGoogle Scholar8. SPEERT H: Local action of sex hormones, Physiol. Rev., 1948, xxviii, 23-50. CrossrefGoogle Scholar9. RHOADS CP: Recent advances in treatment of cancer, Jr. Am. Med. Assoc., 1948, cxxxvi, 305-308. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nutley, New Jersey*Presented at the Twenty-Ninth Annual Session of the American College of Physicians, San Francisco, California, April 21, 1948. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1948Volume 29, Issue 4Page: 595-600KeywordsEstradiolEstrogensSteroids ePublished: 1 December 2008 Issue Published: 1 October 1948 PDF downloadLoading ...
Effect of pregnancy, in the year prior and after treatment for breast carcinoma, on survival and recurrence in women with breast cancer younger than 35 years. GETNA GROUP
Authors: R. Largillier, A. Savignoni, J. Gligorov, P. Chollet, M. Guillaume, M. Spielmann, E. Luporsi, B. Asselain, B. Coudert, M. Namer
Journal: Journal of Clinical Oncology (2006)

553 Background: The goal of this study was to assess the effect of pregnancy on the subsequent risk of recurrences after treatment for breast carcinoma, adjusted on established prognostic factors Methods: Between 1990 and 1999, 908 patients aged under 35 years old were treated for a non metastatic and unilateral invasive breast carcinoma in eight french hospitals, members of the GETNA association. The median follow-up period was 87 months. Mean age was 31.4 years old. Estrogen receptor (ER) status, lymph node involvement, tumor size, histological grade and pregnancy were evaluated as potential risk factors for recurrence and death in a multivariate analysis. A modified model was constructed using the four independent variables derived from the previous multivariate Cox model and the annual risk of death and recurrences were studied. Results: Women who gave birth within one year prior to diagnosis (n=105, 11, 8%) were more likely to have axillary node positive (&gt; N1:48%, vs 35%, p=0.009) important tumor size (&gt;T2:75% vs 55%, p=0.0002), and ER negative (54%, vs 42%, p=0.031). In univariate analysis, pregnancy the year before carcinoma diagnosis increased the risk of death, HR=1.5 [1.05–2.20] (p=0.028) and local recurrence, HR=1.71 [1.06–2.76] (p=0.027). In multivariate analysis, only influence on local recurrence is confirmed, HR=1.75 [1.08–2.84] (p=0.006). Patients who experienced a pregnancy after diagnosis and treatment (n=118, 13.4%) did not tend to have better prognosis regarding axillary node positive (&gt; N1:71%, vs 61%, p=0.051), tumour size (&gt; T2:53.4% vs 59.2%, p=0.49), ER negative (ER:44.2% vs 43.6%, p=0.92) and were significantly younger (&lt;30 years old 52.5% vs 28%, p&lt;10 −4 ). The overall survival after five years was 97% for women who experienced a pregnancy and only 80% for those who did not (p&lt; 0.0001). Conclusions: In this large study population, pregnancy was not associated with poorer survival and the healthy mother effect was studied. For the purpose of advising women on the decision to go forward with pregnancy, was studied after the diagnosis and treatment of breast carcinoma, the annual risk of recurrences. Study granted by Sanofi-Aventis. Acknoledgements to OSMO for its operational support. No significant financial relationships to disclose.
Advanced Age, Antithrombotic Strategy, and Bleeding in Non–ST-Segment Elevation Acute Coronary Syndromes
Authors: Renato D. Lopes, Karen P. Alexander, Steven V. Manoukian, Michel E. Bertrand, Frederick Feit, Harvey D. White, Charles V. Pollack, James Hoekstra, Bernard J. Gersh, Gregg W. Stone, E. Magnus Ohman
Journal: Journal of the American College of Cardiology (2009)
O078 : The prevalence and mortality of acute-on-chronic liver failure defined by APASL vs. EASL-CLIF Consortium: A multicenter, retrospective cohort study in Korea (kaclif study)
Authors: D.S. Song, T.Y. Kim, D.J. Kim, H.Y. Kim, D.H. Shinn, E.L. Yoon, J.H. Sohn, C.W. Kim, Y.K. Jung, K.T. Suk, J.M. Yang, H.J. Lee
Journal: Journal of Hepatology (2015)
Abstract 828: Plasma Parathyroid Hormone and Risk of Congestive Heart Failure in the Community
Authors: Emil Hagstrom, Per Hellman, Tobias E Larsson, Erik Ingelsson, Lars Berglund, Johan Sundstrom, Hakan Melhus, Claes Held, Lars Lind, Karl Michaelsson, Johan Arnlov
Journal: Circulation (2009)
Phenelzine versus imipramine in the treatment of probable atypical depression: defining syndrome boundaries of selective MAOI responders
Authors: F M Quitkin, J W Stewart, P J McGrath, M R Liebowitz, W M Harrison, E Tricamo, D F Klein, J G Rabkin, J S Markowitz, S G Wager
Journal: American Journal of Psychiatry (1988)

Sixty patients with probable atypical depression--defined as meeting Research Diagnostic Criteria for depressive illness, having reactive mood, and having one of four associated symptoms (hyperphagia, hypersomnolence, leaden feeling, and sensitivity to rejection)--took part in a study contrasting phenelzine, imipramine, and placebo. Phenelzine was found to be superior to imipramine and placebo. These results were compared to results from a sample of 120 patients with identical characteristics, except that they had more than one associated atypical symptom (full atypical syndrome). The size of the drug effect was comparable in patients with full atypical and partial atypical syndromes.
The immune microenvironment in hepatocellular carcinoma: Identification of functional immune gene signatures associated with etiology or prognosis
Authors: Alessandra Nardin, Marissa Teo, Charlene Tow, Victor Wong, Alexandre Bolze, Jean-Pierre Abastado, Han Chong Toh
Journal: Clinical Cancer Research (2007)

B70   Although most tumors are immunogenic, the immune system is rarely able to block progression of established tumors. This is partly due to immunosuppressive mechanisms established within the tumor microenvironment. A better understanding of the composition, polarization, and function of the tumor immune microenvironment is important to design more effective treatments. The purpose of our studies is to describe the immune identity of human tumors, define how it may impact clinical end-points, and model how it is affected by treatment. Hepatocellular carcinoma is a highly aggressive cancer which is promoted by chronic liver inflammation, often caused by viral infections as Hepatitis B or C viruses (HBV or HCV). By transcriptome analysis and immunohistochemistry, we have analyzed the type and polarization of the immune cell infiltrate in the liver from patients with viral or non-viral-related tumors. Functional gene clusters associated with T cells, NK cells, inflammatory, myeloid or neutrophil signatures have been identified. Associations between chemokine/cytokine genes and markers of immune cell subsets suggest mechanisms responsible for recruitment and polarization of immune cells within the diseased liver. We found an important immune infiltration in non-malignant (but mostly cirrhotic or inflamed) liver tissues; the majority of the immune genes tested, and in particular the inflammation/myeloid signature, were on the other hand decreased in tumor samples. Among tumors with different etiology, the CD8/NK/NKT cell signature was significantly lower in tumors with non-viral etiology compared to those from HBV patients. HBV tumors are more heterogeneous with regard to their immune microenvironment; we are currently evaluating which factors are associated with these differences, including tumor stage, patient survival, and viral genotype.
Progress on eliminating neglected tropical diseases is too slow, report warns
Authors: A. Gulland
Journal: BMJ (2015)

The number of people receiving treatment for at least one neglected tropical disease is increasing, but progress is still too slow to meet key targets, a new report has warned.

The third monitoring report on progress to eliminate neglected tropical diseases1 showed that 43.3% of the world’s people who need treatment with preventive chemotherapy for at least one of five neglected tropical diseases have received it. This was up from 35.5% in 2008. The disease with the largest treatment coverage is …
Abstract 8927: Double-hump Syndrome: The Presence Of Extreme Interatrial Conduction Delay is Associated With Regularization and Progressive Slowing of Atrial Arrhythmias in a Subgroup of Patients With Hypertrophic Cardiomyopathy
Authors: Ferdi Akca, Kadir Caliskan, Folkert Ten Cate, Luc Jordaens, Tamas Szili-Torok
Journal: Circulation (2012)

Background: In patients with hypertrophic cardiomyopathy (HCM) extreme interatrial activation delay (IAD), indicated by complete separation of the right and left atrial activation on the surface ECG (double hump P wave), was associated with regularization and increase of the cycle length (CL) of recurrent atrial tachycardias (ATs).We aimed to determine the prevalence and the predisposing clinical factors for this clinical entity. Methods: We used data from our HCM registry (n=174 pts, mean age: 53±14 yrs). Data of patients with separated P wave, regularization and slowing of ATs (group I, 5 pts, 2.9%) were compared with 122 control patients with HCM without ATs (group II.). The following parameters were analyzed: P wave morphology and change in P wave duration (ΔP and Pmax), changes in AT CL (ΔATCL), echocardiography parameters including interatrial septal thickness (IAS-T), E/A ratio, E/E prime ratio and fractional shortening (FS) and results of genetic testing. Results: Overall, 9 pts (5.1%) had double hump P waves. This was associated with AT CL prolongation in 5 pts, who were older (66±11 yr vs. 50±14 yr, p=0.016) and had longer follow-up (13,8±1,8 years vs. 7,8± 4,7 years, p=0.005). The ΔATCL was 121±134 ms (range [40-360]) in group I. Echocardiography confirmed double mitral and tricuspid inflow A waves in all group I. pts. Pmax and ΔP were significantly larger in group I (166±33 ms vs. 105±22 ms, p&lt;0.001; 52±26 ms vs. 9±13 ms, p&lt;0.001, respectively). Group I. had an increased LA size as compared to group II. (58±12 mm vs. 45±8 mm, p=0.001) and higher E/A and E/E prime ratios (1,99±1,2 vs. 1,23±0,5, p=0.005 and 20,9±13 vs. 13,1±6,0, p=0.011, respectively). There were no differences in IAS-T and in FS (superior IAS: 4,4±0,1 mm vs. 5,2±1,7 mm, p=NS; inferior IAS: 5,8±0.1 mm vs. 5,7±2,2 mm, p=NS; 38,4±5 % vs. 40,4±9 %, p=NS, respectively). All identified mutations were typical Dutch founder mutations of the MYBPC3 gene. Conclusions: A subgroup of HCM patients have an unique combination of symptoms of separated P wave, regularization and slowing of ATs. Interatrial conduction delay is not related to IAS-T, however, it is associated with larger atria and higher LA pressures. The presence of double hump syndrome is associated with MYBPC3 myosin binding protein mutations.
Abstract 10752: Trends in Hospitalization for Infective Endocarditis at US Children's Hospitals: Impact of the 2007 American Heart Association Antibiotic Prophylaxis Guidelines
Authors: Sara K Pasquali, Xia He, Brian W McCrindle, Jane W Newburger, Jennifer S Li, Samir S Shah
Journal: Circulation (2011)

Background: In April 2007 the American Heart Association published guidelines recommending cessation of antibiotic prophylaxis for infective endocarditis (IE) prior to dental procedures for all but the highest risk patients. The impact of these guidelines is unclear. We examined trends in IE hospitalizations at US Children's Hospitals during this time period. Methods: The Pediatric Health Information Systems (PHIS) Database was used to evaluate children <18 yrs hospitalized with IE at 37 centers submitting data from 2003-2010. Only the index hospitalization was analyzed. Using Poisson regression, we evaluated the number IE hospitalizations over time (raw and indexed to total hospital admissions). Results: A total of 1157 IE cases were identified: median age 2.9 years (interquartile range 2.5mo - 12.4yr), 31% had a diagnosis of congenital heart disease (CHD). In-hospital mortality was 1.1%. We did not detect a significant change in the number of IE cases over time: 1.6% difference in annual number of cases...