tbuckley/cabot-search huggingface dataset:
A DISCUSSION OF A THERAPEUTIC TEST AND A PROVOCATIVE TEST IN GOUTY ARTHRITIS
Authors: L. Maxwell Lockie
Journal: Annals of Internal Medicine (1939)

Article1 November 1939A DISCUSSION OF A THERAPEUTIC TEST AND A PROVOCATIVE TEST IN GOUTY ARTHRITISL. MAXWELL LOCKIE, M.D., F.A.C.P.L. MAXWELL LOCKIE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-5-755 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe first part of this paper will be devoted to a discussion of the effect of colchicine on gouty arthritis. The second part concerns the use of a diet high in fat, low in carbohydrate, and low in protein as a means of provoking attacks of gouty arthritis in some gouty patients.During the past 10 years the physicians of the United States have realized the apparent increase in the number of cases of gout and the occurrence of a symptom of gout—namely gouty arthritis. Before the work of Hench,1it was thought by many to be a disease which...References1. HENCHVANZANTNOMLAND PSFRR: Basis for the early differential diagnosis of gout: a clinical comparison of 100 cases each of rheumatic fever, infectious arthritis and gout, Collected Papers of the Mayo Clinic and Mayo Foundation, 1928 xx, 790. Google Scholar2. LOCKIEHUBBARD LMRS: Gout: changes in symptoms and purine metabolism produced by high fat diets in four gouty patients, Jr. Am. Med. Assoc., 1935, civ, 2072. CrossrefGoogle Scholar3. HARDINGALLENEAGLESVAN WYCK VJKDBAHB: The effect of high fat diets on the content of uric acid in the blood, Jr. Biol. Chem., 1925, lxiii, 37. CrossrefGoogle Scholar4. LENNOX WG: Increase of uric acid in the blood during prolonged starvation, Jr. Am. Med. Assoc., 1924, lxxxii, 602. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Buffalo, New York*Read at the New Orleans meeting of the American College of Physicians March 30, 1939.From the Buffalo General Hospital and the University of Buffalo Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDer GichtanfallDOES COLCHICINE WORK? THE RESULTS OF THE FIRST CONTROLLED STUDY IN ACUTE GOUTKlinisches Bild und Diagnose der GichtArthropathia uricaSolid and liquid nourishment in goutPharmacology of Drugs Used in Treatment of Acute GoutDie Therapie des GichtanfallesColchicineSpecificity of Colchicine Test 1 November 1939Volume 13, Issue 5Page: 755-760KeywordsArthritisCarbohydratesColchicineDietFatsGoutProteins ePublished: 1 December 2008 Issue Published: 1 November 1939 PDF downloadLoading ...
P0218 : Factors associated with hemodynamic response to propranolol and carvedilol in cirrhotic patients
Authors: S. Bota, T. Reiberger, M. Mandorfer, R. Schwarzer, P. Schwabl, M. Trauner, A. Ferlitsch, M. Peck-Radosavljevic
Journal: Journal of Hepatology (2015)
Pneumonia Hospitalizations Among Young Children Before and After Introduction of Pneumococcal Conjugate Vaccine —United States, 1997-2006
Authors: C. G. Grijalva, M. R. Griffin, J. P. Nuorti, N. D. Walter
Journal: JAMA (2009)

including licensure of polymerase chain reaction-based rapid tests for GBS and a population-based review of approximately 8,000 labor and delivery records of births in 2003 and 2004 in the ABCs population. 9 Information for patients, health-care providers, and public health practitioners regarding GBS is available from CDC at http://www.cdc.gov/groupbstrep.
Abstract 15544: Beneficial Effects of Exercise-based Cardiac Rehabilitation on HDL-mediated Cholesterol Efflux Capacity in Patients with Acute Coronary Syndrome
Authors: Shinji Koba, Makoto Ayaori, Harumi Kondo, Yuya Yokota, Fumiaki Furuyama, Fumiyoshi Tsunoda, Makoto Shoji, Katsunori Ikewaki, Youichi Kobayashi
Journal: Circulation (2014)

Introduction: Recent studies reported that low HDL-mediated cholesterol efflux capacity rather than low HDL-cholesterol (HDL-C) levels is strongly associated with the increased risk for coronary artery disease. Exercised-based cardiac rehabilitation (CR) can increase HDL-C. However it remains unclear how CR ameliorate HDL function.

Methods: We used a cell-based cholesterol efflux system including incubation of 3H-cholesterol labeled macrophages with apolipoprotein B-depleted plasma at the onset of acute coronary syndrome (ACS) and at the end of the 6-month CR program in 50 male and 10 female patients with ACS. Cardio-pulmonary exercise tests were performed at the beginning and the end of CR program. All patients received successful percutaneous coronary intervention on admission.

Results: (Table): Fifty-three patients completed CR program. Compared with patients dropped out from CR program, CR participants showed marked amelioration in serum lipid levels, increased efflux capacity, and improved exercise capacity. Spearman’s rank correlation coefficient analysis revealed that % increases of Efflux capacity were significantly associated with % increases in HDL-C (r = 0.647, p < 0.0001), while no association between increases in efflux capacity and increases in cardiopulmonary fitness was observed.

Conclusions: CR can markedly increase both HDL-C and HDL cholesterol efflux capacity. These results suggest that CR is very useful therapy for the reverse cholesterol transport, and the secondary prevention.

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Abstract 15492: IVUS Assessment of Patients with Early, Late and Very Late Stent Thrombosis after Sirolimus-Eluting Stent Implantation: Final IVUS Results From the RESTART Registry
Authors: Teruyoshi Kume, Katsuhisa Waseda, Ken Kozuma, Akiyoshi Miyazawa, Nobuaki Suzuki, Tadanori Aizawa, Kazuaki Mitsudo, Shunichi Miyazaki, Tetsu Yamaguchi, Takaaki Isshiki, Takeshi Kimura, Peter J Fitzgerald, Yasuhiro Honda
Journal: Circulation (2011)

Background: RESTART is the first nationwide multicenter registry of patients who developed definite stent thrombosis (ST) after sirolimus-eluting stent (SES) implantation. The aim of this IVUS stud...
Quality and Safety in Health Care, Part I
Authors: Jay Harolds
Journal: Clinical Nuclear Medicine (2015)

Five pioneers had a huge impact on the quality movement in health care in the United States. Ernest Codman contributed in many ways, including his focus on outcome analysis. Avidis Donabedian is known for his focus on the 3 domains of structure, process, and outcome in health care. Walter Shewhart is known especially for the control chart and early work on what W. Edwards Deming made into the PDSA cycle. Deming is also known for other contributions, including his 14 points of management, correcting system problems rather than blaming the workers, and his System of Profound Knowledge. Juran is known for the Pareto principle and his emphasis on customer satisfaction and addressing the human, not just statistical side, of quality improvement.
Abstract 3195: Is the Extent of Exercise VO <sub>2</sub> Oscillations Related to the Severity and Prognisis of Heart Failure?
Authors: Takuya Taniguchi, Hiroshi Takaki, Motoaki Ibuki, Ryo Namikawa, Shogo Oishi, Rika Kawakami, Teruo Noguchi, Yoichi Goto, Masaru Sugimachi
Journal: Circulation (2008)

Purpose : Exercise VE or VO 2 oscillation (OSC) as well as exercise hyperventilation is an ominous sign in patients with heart failure. However, unlike exercise hyperventilation that is readily evaluated by VE/VCO 2 slope, OSC have only been estimated in a qualitative manner (i.e., “present” or “absent”). We hypothesized that the extent of OSC may be related to the severity and prognosis of heart failure. Methods : From a consecutive series of &gt;4700 cardiopulmonary bicycle exercise tests for recent 5.5 years, we examined the presence of OSC both by visual inspection and by our previously developed method where we estimated Ratio (Low frequency power/Total power) indicative of abnormal slow VO2 OSC (0.5–1.25 cycle/min) by repeating FFT power spectrum analysis (4-min time-window, overlapping every 30 sec). Results : We found VO 2 OSC (defined as Ratio &gt;34.2%) in 175 patients, who were grouped by a median split into Group-H with moderate-to-pronounced OSC (Ratio &gt;42, n=88) and Group-L with mild OSC (Ratio &lt;42, n=87). Compared with Group-L, Group-H had lower peak VO 2 (17.5 ± 4.4 vs 20.9 ± 4.4 ml/min/kg, p&lt; 0.0001) and exhibited higher VE/VCO 2 slope (38.3 ± 12.4 vs 32.5±5.7, p=0.0001), BNP level (308 ± 306 vs 172 ± 144 pg/ml, p&lt;0.001), and NYHA functional class (1.9 ± 0.7 vs 1.6 ± 0.6, p=0.006). During the median follow-up period of 1093 days, cardiac deaths and hospital admissions for heart failure more frequently occurred in Group-H than in Group-L (see Figure ). Conclusions : The data indicate that the more pronounced the exercise VO 2 oscillations, the more severe the status of heart failure. Moderate-to-pronounced forms of exercise VO 2 oscillations predict an even poorer prognosis.
Abnormalities of Chromosome Band 8p11 in Leukemia: Two Clinical Syndromes Can Be Distinguished on the Basis of MOZ Involvement
Authors: Ricardo C.T. Aguiar, Andrew Chase, Stephanie Coulthard, Donald H.C. Macdonald, Melina Carapeti, Andreas Reiter, Jastinder Sohal, Anne Lennard, John M. Goldman, Nicholas C.P. Cross
Journal: Blood (1997)
Abstract 1803: Catheterization without In-hospital Revascularization is Associated with Increased Long-term Mortality in Patients with Non-ST Elevation Myocardial Infarction and Significant Coronary Artery Disease
Authors: Mark Y Chan, Kenneth W Mahaffey, Jie-Lena Sun, Karen S Pieper, Harvey D White, Philip E Aylward, James J Ferguson, Robert M Califf, Matthew T Roe
Journal: Circulation (2007)

Background: Despite guidelines recommendations for early invasive management in non-ST-elevation myocardial infarction (NSTEMI), some patients (pts) with significant coronary artery disease (CAD) found on early angiography do not undergo revascularization. The prevalence, clinical features, and long-term prognosis of this population have not been well-characterized. Methods: We evaluated 8225 NSTEMI pts from the SYNERGY trial (2002–2004) with &gt;50% stenosis in at least 1 epicardial artery who received in-hospital percutaneous coronary intervention (PCI), in-hospital coronary artery bypass grafting (CABG), or no revascularization before discharge (medical management). A propensity-adjusted Cox proportional hazards model was used to compare death/MI rates at 6 months and mortality rates at 1 year among the 3 subgroups starting from the time of hospital discharge. Results: A total of 2633 of 8255 pts (32%) were medically managed, 4294 (52%) underwent PCI, and 1298 (16%) underwent CABG. Clinical features and unadjusted outcomes are shown below. Guidelines-recommended discharge medications were used in a large proportion of patients, but those undergoing PCI most commonly received evidence-based therapies. The adjusted risk of 6-month death or MI was 2.19 (95% CI: 1.79–2.67) for medical management compared with PCI, and 3.07 (95% CI: 2.18 – 4.34) for medical management compared with CABG. The adjusted risks of 1-year mortality for medical management were 1.52 (95% CI: 1.07–2.17) and 1.70 (95% CI: 0.96–3.03), respectively. Conclusion: A substantial proportion of NSTEMI pts with significant CAD are managed medically without in-hospital revascularization. These pts have higher-risk clinical characteristics and worse outcomes compared with those who undergo PCI or CABG, despite fairly good use of evidence-based medications. Therefore, innovative treatment strategies are needed to mitigate the increased risk of adverse outcomes in this population. Baseline Characteristics, Discharge Medications, and Unadjusted Clinical Outcomes for the 3 Groups
Anti-Inflammatory Treatment With Colchicine in Stable Chronic Heart Failure
Authors: Spyridon Deftereos, Georgios Giannopoulos, Vasiliki Panagopoulou, Georgios Bouras, Konstantinos Raisakis, Charalampos Kossyvakis, Sofia Karageorgiou, Charalampos Papadimitriou, Maria Vastaki, Andreas Kaoukis, Christos Angelidis, Stamatina Pagoni, Vlasios Pyrgakis, Dimitrios Alexopoulos, Antonis S. Manolis, Christodoulos Stefanadis, Michael W. Cleman
Journal: JACC Heart Failure (2014)

The purpose of this study was to test the efficacy of a 6-month course of anti-inflammatory treatment with colchicine in improving functional status of patients with stable chronic heart failure (CHF). CHF has been shown to be associated with inflammatory activation. Inflammation has been designated as a therapeutic target in CHF. Patients with stable CHF were randomly assigned to colchicine (0.5 mg twice daily) or placebo for 6 months. The primary endpoint was the proportion of patients achieving at least one-grade improvement in New York Heart Association class. Two hundred sixty-seven patients were available for final evaluation of the primary endpoint: its rate was 11% in the control group and 14% in the colchicine group (odds ratio: 1.40; 95% confidence interval: 0.67 to 2.93; p = 0.365). The rate of the composite of death or hospital stay for heart failure was 9.4% in the control group, compared with 10.1% in the colchicine group (p = 0.839). The changes in treadmill exercise time with treatment were insignificant and similar in the 2 groups (p = 0.938). C-reactive protein and interleukin-6 were both significantly reduced in the colchicine group (–5.1 mg/l and –4.8 pg/ml, respectively; p < 0.001 for both, compared with the control group). According to this prospective, randomized study, anti-inflammatory treatment with colchicine in patients with stable CHF, although effective in reducing inflammation biomarker levels, did not affect in any significant way patient functional status (in terms of New York Heart Association class and objective treadmill exercise tolerance) or the likelihood of death or hospital stay for heart failure.
Angiodysplasia in the Colon and Rectum
Authors: W. Höchter, J. Weingart, W. Kühner, E. Frimberger, R. Ottenjann
Journal: Endoscopy (1985)

In a prospective study, the occurrence of angiodysplasia was investigated by total colonoscopy in 1938 patients. Angiodysplasia was found in 59 patients, i.e. 3%. 12 out of 59 patients were admitted for acute or chronic peranal hemorrhage or anemia. 47 out of 59 patients were asymptomatic. The site of the lesions was as follows: cecum 37%, ascending colon 17%, transverse colon 7%, descending colon 7%, sigmoid colon 18% and rectum 14%. Histological confirmation was obtained in 15 out of 37 biopsies. The endoscopic appearance was variable, most of the vascular dilatations being smaller than 5 mm (n = 47), with a homogeneous (n = 35) or inhomogeneous (n = 24) structure and a regular (n = 34) or irregular (n = 25) border. The lesions were single (n = 34) as well as multiple (n = 25), they were usually flat (n = 54), seldom slightly prominent (n = 5). Concomitant pathological findings in the bowel were diagnosed in 33 out of 59 patients: diverticula in 32%, adenomas in 24% and carcinomas in 8.5%. Right hemicolectomy for bleeding angiodysplasia is indicated only if endoscopic therapy has failed and other colorectal sources of bleeding, and especially angiodysplasia in the left colon and rectum have been excluded by endoscopy or angiography.
Adoptive Transfer of Anti-CD3–Activated CD4+ T Cells Plus Cyclophosphamide and Liposome-Encapsulated Interleukin-2 Cure Murine MC-38 and 3LL Tumors and Establish Tumor-Specific Immunity
Authors: Mark L. Saxton, Dan L. Longo, Holly E. Wetzel, Henry Tribble, W. Gregory Alvord, Larry W. Kwak, Arnold S. Leonard, Claudio Dansky Ullmann, Brendan D. Curti, Augusto C. Ochoa
Journal: Blood (1997)
Number of Yellow Plaques Detected in a Coronary Artery Is Associated With Future Risk of Acute Coronary Syndrome
Authors: Tomohito Ohtani, Yasunori Ueda, Isamu Mizote, Jota Oyabu, Katsuki Okada, Atsushi Hirayama, Kazuhisa Kodama
Journal: Journal of the American College of Cardiology (2006)
Development of a novel injectable drug delivery system for subconjunctival glaucoma treatment
Authors: Karsten Voss, Karen Falke, Arne Bernsdorf, Niels Grabow, Christian Kastner, Katrin Sternberg, Ingo Minrath, Thomas Eickner, Andreas Wree, Klaus-Peter Schmitz, Rudolf Guthoff, Martin Witt, Marina Hovakimyan
Journal: Journal of Controlled Release (2015)
Abstract 1877: Experimental Validation of Circumferential Subendocardial and Subepicardial Myocardial Strain during Dobutamine Stress Echocardiography in Ischemic Conditions
Authors: Patricia Reant, Louis Labrousse, Stephane Lafitte, Lilianne Tariosse, Simone Bonoron-Adele, Philippe Padois, Claude Deville, Raymond Roudaut, Pierre Dos Santos
Journal: Circulation (2007)

Background: Strain echocardiographic techniques have been developed in order to quantify myocardial contraction but are currently based on a transmural myocardial analysis whereas subendocardial (ENDO) and subepicardial (EPI) layers have different response to ischemia. Recent development in strain software enables to investigate simultaneously strain in 2 myocardial layers. Objectives: To assess and validate this new tool for the detection of ischemia during dobutamine stress echocardiography (DSE). Methods: In 6 open-chest anesthetized pigs, circumferential strain (CS) was studied before and during dobutamine infusion, in absence of coronary stenosis and in ischemic conditions produced by: 2 degrees of non flow-limiting stenoses reducing left anterior descending (LAD) artery hyperemic flow by 20% and then by 60% (NFLS20 and NFLS60), and 1 flow-limiting stenosis reducing resting LAD flow by 25% (FLS25). Agreement between CS echocardiography in ENDO and EPI layers in risk area (RA) and sonomicrometry was evaluated by linear regression and Bland-Altman analysis. CS in ENDO and EPI layers were studied in absence or coronary stenosis and in ischemic condition, in RA and in control area (CA). Results: Good correlations and agreements were observed between echocardiography and sonomicrometry at rest and during dobutamine : ENDO CS: r=0.66, P&lt;0.001 and r=0.69, P&lt;0.0001; EPI CS: r=0.65, P&lt;0.01 and r=0.62, P&lt;0.001. At rest, both ENDO and EPI CS in the RA were significantly decreased in the presence of FLS25. During dobutamine infusion, ENDO CS was significantly reduced in the presence of NFLS20 and EPI CS in the presence of NFLS60. Conclusions: Multilayer strain echocardiography provides accurate assessment of LV regional function. Evaluation of ENDO and EPI strains during DSE has real potential to improve detection of ischemia in clinical practice.
Use of baseline quality of life (QOL) as compared with performance status (PS) as prognostic factors for overall survival (OS) in patients with metastatic colorectal cancer (mCRC)
Authors: J. H. Turja, A. Grothey, D. J. Sargent, D. W. Szydlo, X. Zhao, M. E. Campbell, R. M. Goldberg, J. A. Sloan
Journal: Journal of Clinical Oncology (2008)

4016 Background: The prognostic significance of pretreatment PS for outcome in mCRC is well established. In contrast, the importance of baseline QOL as a prognostic factor in mCRC is less well understood. We performed an analysis of the effect of baseline QOL on OS in Intergroup trial N9741 (Goldberg JCO 2004). Methods: 1,253 patients (m767, f486; age 61yrs, 19–88; PS0–1 1,202, PS2 51) with mCRC participating in N9741 (IFL 374 pts, FOLFOX4 539, IROX 340 pts) provided data at baseline on overall QOL on a 0–100 point scale. OS (whole study group and per study arm) was tested for association with high vs low QOL (split at median baseline QOL score), and clinically deficient (CD-QOL, score 0–50, n=133) vs not clinically deficient (nCD-QOL, score 51–100, n=1,120) QOL. A multivariate analysis was performed to adjust for effect of treatment arm and PS on OS. Results: Baseline QOL was a strong predictor of OS for the whole study group (low vs high QOL: 15.8 mos vs 19.8 mos, p<0.0001; CD-QOL vs nCD-QOL: 11.5 mos vs 18.4 mos, p=0.0003). This effect was consistently seen in all treatment arms (low/high QOL: IFL 12.4/17.4 mos, FOLFOX 18.7/20.9 mos, IROX 12.8/20.9 mos; CD-QOL/nCD-QOL: IFL 13.2/15.2 mos, FOLFOX 11.5/20.6 mos, IROX 8.7/18.1 mos). Baseline QOL was associated with PS (p<0.0001). However, after adjusting for PS and treatment arm, baseline QOL was still strongly correlated with OS (low/high QOL p=0.0001; CD/nCD-QOL p=0.0016). Conclusions: Baseline QOL is a strong and independent prognostic factor for OS in patients with mCRC and should thus be considered as a stratification factor for future palliative randomized treatment trials in this disease. The demonstration that patient-assessed QOL and physician-assessed PS are independent prognostic factors suggests that these assessments are non-overlapping, providing complimentary important prognostic information. No significant financial relationships to disclose.
Subcutaneous Bone Formation in Chronic Venous Insufficiency of the Legs
Authors: R E CONDON, H N HARKINS
Journal: JAMA (1963)

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