tbuckley/cabot-search huggingface dataset:
Neoadjuvant chemoradiotherapy with capecitabine or 5-fluorouracil (5FU) infusion plus leucovorin in elderly patients with locally advanced rectal cancer.
Authors: K. B. Ribeiro, H. F. Oliveira, P. T. F. Reis, O. Feres, J. J. R. Rocha, F. E. Zola, N. F. Vieira, F. N. Segato, F. A. Trevisan, F. M. Peria
Journal: Journal of Clinical Oncology (2011)

e19634
Die Grösse und Form der roten Blutkörperchen bei Menschen verschiedenen Alters unter physiologischen Verhältnissen
Authors: Carl August Hernberg
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reproduction after cancer: A nationwide, population-based study
Authors: H. Stensheim, M. Cvancarova, B. Møller, S. D. Fosså
Journal: Journal of Clinical Oncology (2008)

9646 Background: Despite improved treatment and more emphasis on fertility preservation, reproduction rates are expected to be lower in young adult cancer survivors. Methods: We investigated reproduction rates in 23,506 cancer survivors and 117,530 age- matched controls in a study with data from the Cancer Registry and the Medical Birth Registry of Norway. All subjects were born after 1950 or later and diagnosed with cancer between 1967–2002. The median age at diagnosis was 31 (males) and 34 (females) years, range 16–45. Follow-up was from the date of diagnosis for patients or assigned date of diagnosis for controls, until first pregnancy after cancer (of at least 16 weeks of duration), emigration, death or Dec 31, 2005. Cox regression models were used to compute overall reproduction rates for both genders, and for breast and testicular cancer patients. The hazard rates (HRs) were adjusted for age at diagnosis and birth-decade, and stratified by extent of the disease (localized, regional and distant), number of pre-diagnosis children, gender and diagnostic period (before/after 1990). See table below. Results: Overall, survivors with less than 2 children prior to diagnosis were more likely to have a child after cancer than survivors with higher parity before cancer, (p<0.001). Patients with localized cancer were more likely to have children than those with distant disease (HR=2.57 [2.11–3.13] for males and HR=3.80 [2.64–5.51] for females). Males diagnosed after 1990 demonstrated higher reproduction rates than patients diagnosed before 1990, HR=1.23 [1.10–1.40]. No such statistically significant period change was seen in females. Conclusions: This population-based study revealed lower reproduction rates in cancer survivors overall than in the normal population. However, the rates were higher for male compared to female patients. Localized disease, less than 2 children prior to diagnosis and being diagnosed after 1990 gave significantly higher probability for having a child after cancer. Diagnosed Children prior to diagnosis, no. Males Females Testicular cancer Breast cancer Before 1990 0 0.53 [0.49–0.58] 0.65 [0.59–0.71] 0.55 [0.48–0.63] 0.69 [0.46–1.02] 1 0.58 [0.44–0.59] 0.41 [0.36–0.47] 0.51 [0.40–0.64] 0.36 [0.20- 0.63] 2 or more 0.49 [0.40–0.60] 0.48 [0.41–0.57] 0.38 [0.27–0.54] 0.18 [0.09–0.36] After 1990 0.80 [0.74–0.87] 0.73 [0.67–0.80] 0.75 [0.67–0.85] 0.51 [0.34- 0.74] 1 0.71 [0.63–0.79] 0.50 [0.45- 0.56] 0.75 [0.63–0.88] 0.22 [0.14–0.35] 2 or more 0.71 [0.66–0.81] 0.43 [0.37–0.50] 0.69 [0.56–0.86] 0.19 [0.12–0.31] Ref=controls, [95% CI] No significant financial relationships to disclose.
Adult Primary Care
Authors: [edited by] Pamela Vesta Meredith, Nancy Mathes Horan.
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Catalogue of the Onodi Collection in the Museum of the Royal College of Surgeons of England
Authors: T. B. Layton
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2739: The Proprotein Convertase Subtilisin-kexin Type 9 (PCSK9) R46L Variant Is Associated With Reduced Serum Low-density Lipoprotein Cholesterol In The Italian Population
Authors: I. Guella, R. Asselta, V. Rimoldi, F. Peyvandi, R. Fetiveau, P.A. Merlini, S. Kathiresan, D. Ardissino, P.M. Mannucci, S. Duga, T. Atherosclerosis
Journal: Circulation (2007)
...but members of the public make up their own minds about risks
Authors: K D Gunasekera, A I Hapgood, E L Harvey, T R M H. Benjamin, M S J Jachuck, A L N Jackson, N P A Kronfeld, M I Manikon, C J Mearns, N Mushtaq, F. Adshead
Journal: BMJ (1996)

complacent.As doctors or scientists we are asked to give opinions about a range of issues, not all of which lie within our area of expertise.We will probably also be asked about issues that are at the boundaries of medical and scientific knowledge and about which considerable uncertainty exists.It is incumbent on us to be aware of all the arguments and to be able to communicate the levels of uncertainty associated with them in an understandable fashion.We need to work with the media so that we remain in control of the debates, and, above all, we must preserve our professional credibility at a time when those around us are losing theirs.
Everyday Psychiatry: Concise, Clinical, Practical
Authors: John D. Campbell
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Definition of depression is questionable
Authors: J. H Thakore
Journal: BMJ (1995)

Definition ofdepression is questionable EDITOR,-Mynors-Wallis and colleagues claim that problem solving treatment and amitriptyline are equally effective in major depressive disorder.'Even though they required their patients to meet the research diagnostic criteria for depression, just how severely depressed they were comes into question.To be eligible to take part in the study patients had to score just 13 on the Hamilton depression rating scale.Drug licensing authorities, such as the Committee on Safety of Medicines and the Food and Drug Administration, and most
Abstract 390: Antioxidative and Anti-inflammatory Effects of Statin Modulating Autonomic Nerve Function in Hypercholesterolemic Rabbits
Authors: Yen-Bin Liu, Chau-Chung Wu, Lian-Yu Lin
Journal: Circulation (2008)

Background: We previous showed statins could prevent or reverse cardiac nerve sprouting and sympathetic hyperinnervation induced by hypercholesterolemia (HC) in rabbit models. The significance and mechanisms are unclear. Methods and Results: We studied heart rate variability (HRV) and baroreflex sensitivity (BRS) in 23 rabbits with HC chow, standard chow (Control), or HC chow and atorvastatin. Myocardial content of nitrotyrosine, foam cell formation (RAM 11-positive cell) and serum high-sensitivity C reactive protein (hs-CRP) were measured in 56 rabbits fed with standard chow, HC chow or HC chow and atorvastatin. The status of Rac1 was also examined. The HRV and BRS were significantly reduced in HC rabbits (Control vs. HC; SDNN: 11.7±3.8 vs. 6.0±4.1 ms, p &lt;0.01; RMSSD: 14.6±7.5 vs. 2.8±1.2 ms, p&lt;0.001; LF/HF: 0.29±0.18 vs. 2.0±2.15, p &lt;0.04; BRS: 8.5±4.6 vs. 2.2±2.2 ms/mmHg, p &lt;0.01). Atorvastatin treatment prevented the decreases in HRV and BRS of HC rabbits (Statin, vs. HC; SDNN: 12.0±8.4 ms, p &lt;0.1; RMSSD: 18.2±17.3 ms, p&lt;0.02; LF/HF: 0.39±0.36, p=0.09; BRS: 11.2±4.8 ms/mmHg, p &lt;0.01). Myocardial levels of nitrotyrosine were progressively increased while increasing the dietary cholesterol (Control: 0.34±0.01 nM; 0.25% HC: 0.68±0.04 nM; 0.5% HC: 1.15±0.25 nM; p&lt;0.001). Following statin treatment, levels of nitrotyrosine were significantly reduced (p&lt;0.001), and there was a dose-response relationship between the dosage of atorvastatin and myocardial nitrotyrosine levels. Myocardial RAM 11-positive cells and serum hs-CRP levels were increased in HC (Control vs. HC; RAM 11: 2.3±1.7 vs. 13.1±6.7 /microscopic field, p&lt;0.01; hs-CRP: 1.6±1.0 vs. 7.7±5.2 mg/dl, p&lt;0.01). Atorvastatin significantly reduced the levels of these inflammatory markers (p&lt;0.05). In addition, atorvastatin administration significantly decreased the accentuated myocardial Rac1 expression in HC rabbits. Conclusion: HC rabbits have increased cardiac inflammation and heightened sympathetic tone. Atorvastatin significantly decreased the myocardial inflammation and reduced the cardiac sympathetic tone in HC rabbits. A reduction in myocardial Rac1 by atorvastatin may serve as a molecular mechanism for this reversing cardiac neural remodeling.
Adult craze for breast milk bought online has health risks, experts warn
Authors: S. Mayor
Journal: BMJ (2015)

A recent craze for adults to consume human breast milk that they buy online from websites claiming benefits has no scientific basis and may pose serious health risks, UK and US experts have warned after reviewing evidence.

“Human milk consumption by adults purchasing milk online is ill advised,” said the experts, led by Sarah Steele, from Barts and the London School of Medicine and Dentistry at Queen Mary University of London, writing in the Journal of the Royal Society of Medicine .1 “Health professionals and regulators …
Nasal Myiasis
Authors: Marco A F B Baptista
Journal: New England Journal of Medicine (2015)

A 65-year-old man with chronic rhinosinusitis presented with a 7-day history of bleeding from his nose. He had HIV and HCV coinfection and was not receiving antiretrovirals. Two days before presentation, he had seen worms emerging from his nostril. A video shows findings on nasal endoscopic examination.
Psychiatric Presentations of Medical Illness: Somatopsychic Disorders.
Authors: Richard C. W. Hall
Journal: Annals of Internal Medicine (1981)

When my colleagues and I began the task of assembling this volume, several difficult questions arose: For whom were we writing? Was the purpose to eluci date psychiatric or medical presentation? Should references reflect specific to pical areas, or lead the reader to a more general view of a particular topic? Would a symptom or system approach best serve the reader? Should the volume cover a few areas in detail, or attempt to survey a larger area of knowledge? The present text reflects an attempt to answer these questions. It is designed for the student of medicine who desires a broader understanding of those medi cal illnesses that produce psychiatric aberration. We hope it will be of assis tance to the medical student or house officer studying medicine, neurology, family practice, pediatrics, or psychiatry; as well as to the practicing clinician who wishes a refresher on this subject or a reference for his library. The text is intended to strike a useful balance between medicine and psychiatry by provid ing a list of differentials for specific symptoms or conditions, as well as sugges tions for medical evaluation. References have been chosen which we hope will assist the reader in further study. We have attempted to diversify them and list a spectrum of articles that deal with both academic and practical treatment considerations. The initial volume is divided into four sections that address both a symptom and system approach.
Abstract 2243: <i>In Vivo</i> 3D MR Angiography Reveals Accelerated Collateral Vessel Growth in CD73 <sup>−/−</sup> Mice after Hindlimb Ischemia
Authors: Ulrich Flögel, Yang C Böring, Christoph Jacoby, Jürgen Schrader
Journal: Circulation (2008)

Adenosine is a potent stimulator of angiogenesis, however, its role in arteriogenesis is not yet known. To address this issue we induced severe hindlimb ischemia in a mouse mutant lacking CD73 (ecto-5′-nucleotidase) which shows enhanced monocyte adhesion to the endothelium, considered to be an important initial trigger for arteriogenesis. For serial comparison of blood flow recovery and direct visualization of newly developed collateral vessels in wild-type (WT) and CD73 −/− mice we established a high resolution 3D MR angiography (MRA) protocol. MRA images (field of view 2.56x2.56x1.92 cm 3 , matrix 256x256x192, voxel size 1 nl) of murine hindlimbs were recorded at 9.4 T within a reasonable acquisition time of approximately 30 min and were subsequently segmented and quantified using in-house-developed software. Collateral flow was detected as early as 3 d after ligation reaching a transient maximum 7 d after occlusion. At this time the extent of collateralization in the ischemic area was substantially enlarged in CD73 −/− mice (+70% vs. WT, p&lt;0.05, n=6). The improved blood supply was also reflected in a faster recovery of hindlimb muscle energetics in the mutant compared with WT controls as assessed by 31 P MR spectroscopy in vivo . Histology confirmed the enhanced development of collaterals in CD73 −/− mice. In conclusion, our protocol allows the quantitative assessment of growing collateral vessels in mice. We found that lack of CD73-derived adenosine promotes arteriogenesis. Fig. 1 : MRA from hindlimbs of CD73 −/− mice 7 d after ligation of the femoral artery. Newly developed collateral vessels are colored in green. Insert shows the typical “corkscrew morphology” of the collaterals.
Risk factors associated to invasive infection in children and adolescents with cancer during febrile neutropenia episodes
Authors: F. A. Carlesse, A. Petrilli, L. Y. Weckx, M. S. Cypriano, C. A. Pereira
Journal: Journal of Clinical Oncology (2006)

9046 Background: Febrile neutropenia (FN) after chemotherapy requires prompt introduction of empiric antimicrobial therapy. It has been demonstrated that FN patients do not represent a homogeneous group, and the stratification of infectious risk leads to changes in therapy. Our objectives were to evaluated the efficacy of the antimicrobial regimens used according to the FN institutional protocol and to identify risk factors related to invasive infection in children and adolescents during episodes of FN. Methods: We conducted a prospective study in the Pediatric Oncology Institute (IOP-GRAACC-UNIFESP/SP-Brazil) from March/2003 to June/2004. We analyzed 448 FN episodes in 200 patients, they were classified in high and low risk of invasive infection according to the underling disease and comorbities. Low risk patients (solid tumors, ALL and lymphomas in remission, without comorbities) were treated with oral gatifloxacin as outpatient; whereas high risk (AML, solid tumors, Lymphomas and ALL with comorbities or activity) were treated with cefepime as inpatient. Invasive infection was considered when a culture obtained from a sterile site resulted positive for bacterial and/or fungus or there were clinical and laboratory findings that strongly suggest sepsis. Results: Of 204 (45.5%) episodes treated with gatifloxacin, 72.1% obtained success without modification. Of 206 (46.0%) episodes treated with cefepime, 34.5% obtained success without modification, 38 (8.5%) patients were treated with distinct antibiotic regimen. Invasive infection was observed in 133 episodes (29.6%); 16 (3.6%) deaths occurred, all of them in the high risk group and the overall success was 84.3%. In the logistic regression analysis remained as independent risk factors: age ≤3 ys (OR: 2.3), temperature ≥38.5ºC (OR:1.6), central venous catheter (OR:1.7), underlying active disease (OR:1.6), mucositis (OR:2.4) and diarrhea (OR:2.4). Conclusions: Applying a institutional protocol, it is possible to predict the infectious risk and treat the patients individually .The observed overall success (84.3%), confirms that the therapy based in the protocol was adequate. There was no toxicity associated with gatifloxacin in this study, and no deaths in the low risk group. No significant financial relationships to disclose.
The History and Traditions of the Moorfields Eye Hospital: One Hundred Years of Ophthalmic Discovery and Development.
Authors: E. Treacher Collins
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1876: Functional Effect of Chronic Urotensin II Receptor Antagonist on L-Type Ca <sup>2+</sup> Current in Mouse Model of Progressive Heart Failure
Authors: Peng Zhou, Heng-Jie Cheng, Michael Cross, Michael F Callahan, Bridget Brosnihan, William C Little, Che-Ping Cheng
Journal: Circulation (2008)

Voltage-gated Ca 2+ channels play fundamental roles in the regulation of cardiac function by various neurotransmitters. Recently, we have shown that urotensin II (UII), a potent vasoconstrictor, inhibits L-type Ca 2+ current (I Ca,L ) and produces negative inotropic action. In heart failure (HF), the UII-mediated pathway is upregulated, suggesting a therapeutic value of UII receptor antagonist (UII-ANT) for HF. However, the role and mechanism of chronic UII-ANT in HF is unclear. We tested the hypothesis that chronic UII-ANT may improve cardiac I Ca,L , preventing β-adrenergic deregulation on I Ca,L and limit HF progression. We examined plasma levels of norepinephrine (NE), left ventricular (LV) function, and myocyte I Ca,L responses to isoproterenol (ISO) in 3 age-matched groups of mice: HF (n = 7), 2 months after ISO (150 mg/kg sq for 2 days); HF/UII-ANT (n = 11), 1 month after receiving ISO, then urantide, a potent UII-ANT (10 −5 M/kg/day, sq via implanted osmotic mini pump), given for 1 month; and Controls (n = 7). I Ca,L was measured using whole-cell voltage clamp technique. Compared with controls, ISO-treated mice progressed to HF with 4.7-fold increase in plasma NE (18975 vs 4066 pg/ml) and LV dilatation associated with increased myocyte length (ML, 155 vs120 μm) and heart-to-body weight ratio (H/BW, 7.6 vs 5.5 g/kg). Stroke volume (SV, 30.3 vs 61.4 μl) and ejection fraction (EF, 39% vs 60%) were decreased. Compared with normal myocytes, in HF myocytes, I Ca,L was reduced (50%, 3.7 ± 0.2 vs 7.4 ± 0.2 pA/pF), and I Ca,L response to β-AR stimulation (ISO, 10 −8 M) was attenuated (11% vs 35%) (p &lt; 0.01). In HF/UII-ANT mice, plasma NE (5148 pg/ml), SV (57.9 μl), and EF (57%) returned close to control levels with retained normal ML (124 μm) and H/BW (5.9 g/kg). Moreover, compared with controls, in HF/UII-ANT mice, ISO caused similar increases in the peak I Ca,L (32% vs 35%). Chronic UII-ANT treatment normalizes LV L-type Ca 2+ channel basal function and β-adrenergic regulation, leading to regression of LV and myocyte dysfunction and remodeling in mice with ISO-induced HF. This research has received full or partial funding support from the American Heart Association, AHA National Center.