tbuckley/cabot-search huggingface dataset:
Bibliometric analysis and global trends in uterus transplantation
Authors: Tong Wu, Yangyang Wu, Kebing Nie, Jinfeng Yan, Ying Chen, Shixuan Wang, Jinjin Zhang
Journal: International Journal of Surgery (2024)

Aim: The purpose of this study was to characterize publication patterns, academic influence, research trends, and the recent developments in uterus transplantation (UTx) across the globe. Methods: The Web of Science Core Collection database was searched for documents published from the time the database began to include relevant articles to December 15, 2023. With the use of VOSviewer, Citespace, BICOMB, and Incites, a cross-sectional bibliometric analysis was conducted to extract or calculate the evaluative indexes. Publications were categorized by country, institution, author, journal, highly cited papers, and keywords. The variables were compared in terms of publication and academic influence, which further included citation count, citation impact, Hirsh index, journal impact factor, total link strength, collaboration metrics, and impact relative to the world. Results: A total of 581 papers concerning UTx were initially identified after retrieval, and 425 documents were included. Of the 41 countries participating in relevant studies, the USA and Sweden were in leading positions in terms of publications, citations, and academic influence. The most versatile institution was the University of Gothenburg, which is followed by Baylor University. The most productive scholars and journals were Brännström M. and Fertility and Sterility, respectively. Five groups of cutting-edge keywords were identified: venous drainage, donors and donation, women, fertility preservation, and fertility. Topics about surgery, first live birth, risk, and in vitro fertilization remain hot in this field. Conclusions: UTx is anticipated to enter a golden era in the coming years. This study provides some guidance concerning the authors involved in promoting UTx research, the current development of UTx, and journals to submit their innovative research. This also helps to reach a comprehensive insight and prospect in the near future. In order to establish recognized standards and benefit more patients who are disturbed by uterine infertility, large-scale and well-designed clinical trials are required.
Regarding the significance of plasmatic arginine/homoarginine in neurogenic pulmonary edema following surgery of medulla oblongata tumors patients
Authors: Wei Yang, Jinlin Liu
Journal: International Journal of Surgery (2024)

Dear Editor, We read Wang's study1 with great interest. In this prospective clinical study, the author aims to investigate the fluctuations of neurotransmitters in peripheral venous blood during the perioperative period and to identify independent predictors for postoperative neurogenic pulmonary edema (NPE) in patients with medulla oblongata-involved tumors. They found that decreased concentrations of arginine and homoarginine, the absence of intraoperative use of sevoflurane, and prolonged postoperative tracheal extubation were independent risk factors for postoperative NPE in these 36 medulla oblongata-involved tumor patients. Then, they concluded that these two neurotransmitters' concentrations could serve as potential early warning indicators of postoperative NPE in clinical practice. Despite definite results, we raise some concerns and comments on this study. First, these neurotransmitters' concentrations in a neurosurgical skull base tumor patients' group at seven perioperative time points are lacking in Wang's study. Thus, it is challenging to pinpoint the definite association because there is little information on 39 neurotransmitters in other neurosurgical skull base tumor patients. Without appropriate controls, these two neurotransmitters could be a bystander effect in these neurosurgical skull base tumor patients. Second, the sample size of univariate and multivariate Cox proportional hazards is usually more than 15 times the confounder. The more confounders are analyzed, the more sample sizes are required. In Wang's study, 17 confounders including male, age, without a history of hypertension, medulla oblongata originated et al., and 39 other neurotransmitters confounders were all included. However, the sample size was only 36 patients with medulla oblongata-involved tumors. Thus, the statistical significance of univariate or multivariate analysis of risk factors could result in inappropriate results in Khalid's study. Finally, in this letter, we want to discuss whether a clear association exists between the warning indicators of arginine and homoarginine with postoperative NPE in clinical practice. However, although we felt the need to address this point, we congratulate Zhao's outstanding work1, which gives us this opportunity to discuss the significance of plasmatic arginine/homoarginine in NPE following surgery of medulla oblongata tumor patients. Ethical approval Not applicable. Consent Not applicable. Sources of funding Not applicable. Author contribution W.Y. and J.L.: discussed and wrote the manuscript. Conflicts of interest disclosure We declare no conflicts of interest. Research registration unique identifying number (UIN) Not applicable. Guarantor Jinlin Liu. Data availability statement Not applicable. Provenance and peer review Not applicable. Data availability statement Not applicable.
A commentary on “Pre-emptive infiltration with betamethasone and ropivacaine for postoperative pain in laminoplasty and laminectomy (PRE-EASE): a prospective randomized controlled trial”
Authors: Chaojin Zhu, Xiaoang Ye, Lianguo Wu
Journal: International Journal of Surgery (2024)

aThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China bDepartment of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang,People's Republic of China Chaojin Zhu and Xiaoang Ye contributed equally to this work and share first authorship. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: The Second Affiliated Hospital of Zhejiang Chinese Medical University, 318 Chaowang Road, Gongshu District, Hangzhou, Zhejiang 310005, People's Republic of China. E-mail address: [email protected] (L. Wu). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Association of copeptin levels with patient prognosis and survival in sepsis syndromes: a meta-analysis
Authors: Abhinav Bhattarai, Sangam Shah, Sujata Baidya, Ranjana Thapa, Suyog Bhandari, Eans T. Tuladhar, Subhash P. Acharya, Ranjit Sah
Journal: International Journal of Surgery (2024)

Background: Sepsis syndromes are a major burden in the ICU with very high mortality. Vasopressin and copeptin are released in response to hypovolemia and have shown potential significance in diagnosing sepsis. Objective: To investigate the levels of copeptin in patients with sepsis syndromes and evaluate its relation with patient prognosis and mortality. Methods: Four databases were searched for literature published from inception to the 8th of November 2022. Original research articles where copeptin was measured in sepsis patients and compared with controls were included. Data extraction and synthesis: study characteristics, levels of copeptin in the participants, and copeptin assay description were extracted. Levels of copeptin in patients were pooled and compared with controls in terms of the standard mean difference (SMD) generated using a random-effects model. Results: Fifteen studies met the selection criteria. Copeptin levels were significantly higher in patients with sepsis, severe sepsis, and septic shock as compared to controls [(SMD: 1.49, 95% CI: 0.81–2.16, P &lt;0.0001), (SMD: 1.94, 95% CI: 0.34–3.54, P =0.02), and (SMD: 2.17, 95% CI: 0.68–3.66, P =0.004), respectively]. The highest copeptin levels were noted in septic shock patients. The admission copeptin levels were significantly lower in survivors as compared to nonsurvivors (SMD: −1.73; 95% CI: −2.41 to −1.06, P &lt;0.001). Conclusion and Relevance: Copeptin was significantly elevated in sepsis, severe sepsis, and septic shock. Survivors had a significantly lower copeptin during admission. Copeptin offered an excellent predictability to predict 1-month mortality. Measuring the copeptin in sepsis patients can aid treating physicians to foresee patients’ prognosis.
The association between cataract surgery and mental health in older adults: a review
Authors: Shan Wang, Zijing Du, Chunran Lai, Ishith Seth, Yaxin Wang, Yu Huang, Ying Fang, Huiyi Liao, Yijun Hu, Honghua Yu, Xiayin Zhang
Journal: International Journal of Surgery (2024)

Background: Although cataract surgery has been proposed as a potentially modifiable protective factor for enhancing emotional well-being in cataract patients, studies examining the relationship between anxiety or depression and cataract surgery have yielded inconsistent findings. This review summarizes existing evidence to establish whether cataract surgery is associated with depression and anxiety in older adults. Methods: A literature search was conducted across PubMed, Medline, Web of Science, and Embase databases. An initial screening by abstracts and titles was performed, followed by a review and assessment of the methodological quality of the relevant full papers, and final inclusion of 44 studies were deemed eligible for inclusion in this review. Results: Among 44 included studies, 36 studies (81.8%) were observational studies concerning the association of cataract surgery or cataracts with anxiety or depression, four studies (9.1%) were interventional studies, and four studies (9.1%) were reviews. Cataract surgery notably enhances the mental health of individuals with impaired vision. However, the multifaceted nature of psychological well-being, influenced by various factors, suggests that cataract surgery may not address all aspects comprehensively. Additionally, preoperative anxiety and depression significantly impact cataract surgery outcomes. Conclusion: Vision impairment in older adults is closely associated with increased symptoms of depression and anxiety. While surgical intervention for cataracts improves these symptoms, it might be less effective for mental disorders with multifactorial causes. Notably, anxiety or depression poses challenges to successful preoperative and intraoperative cataract surgeries.
Clinical and economic comparison of laparoscopic versus open hepatectomy for primary hepatolithiasis: a propensity score-matched cohort study
Authors: Xiao-Peng Chen, Wen-Jun Zhang, Bin Cheng, Yuan-Lin Yu, Jun-Lu Peng, Sheng-Hua Bao, Chao-Gang Tong, Jun Zhao
Journal: International Journal of Surgery (2024)

Background: It is unclear whether laparoscopic hepatectomy (LH) for hepatolithiasis confers better clinical benefit and lower hospital costs than open hepatectomy (OH). This study aim to evaluate the clinical and economic value of LH versus OH. Methods: Patients undergoing OH or LH for primary hepatolithiasis at Yijishan Hospital of Wannan Medical College between 2015 and 2022 were divided into OH group and LH group. Propensity score matching (PSM) was used to balance the baseline data. Deviation-based cost modelling and weighted average median cost (WAMC) were used to assess and compare the economic value. Results: A total of 853 patients were identified. After exclusions, 403 patients with primary hepatolithiasis underwent anatomical hepatectomy (OH n =143; LH n =260). PSM resulted in 2 groups of 100 patients each. Although LH required a longer median operation duration compared with OH (285.0 versus 240.0 min, respectively, P &lt;0.001), LH patients had fewer wound infections, fewer pre-discharge overall complications (26 versus 43%, respectively, P =0.009), and shorter median postoperative hospital stays (8.0 versus 12.0 days, respectively, P &lt;0.001). No differences were found in blood loss, major complications, stone clearance, and mortality between the two matched groups. However, the median overall hospital cost of LH was significantly higher than that of OH (CNY¥52,196.1 versus 45,349.5, respectively, P =0.007). Although LH patients had shorter median postoperative hospital stays and fewer complications than OH patients, the WAMC was still higher for the LH group than for the OH group with an increase of CNY¥9,755.2 per patient undergoing LH. Conclusion: The overall clinical benefit of LH for hepatolithiasis is comparable or even superior to that of OH, but with an economic disadvantage. There is a need to effectively reduce the hospital costs of LH and the gap between costs and diagnosis-related group reimbursement to promote its adoption.
Family caregiver outcomes after participating in a Hospital-based family involvement program after major gastrointestinal surgery: a subgroup analysis of a patient preferred cohort study
Authors: Selma CW Musters, Sani Kreca, Susan van Dieren, Hanneke van der Wal-Huisman, Johannes A Romijn, Wendy Chaboyer, Els JM Nieveen van Dijkum, Anne M Eskes
Journal: International Journal of Surgery (2024)

Engaging families in postsurgical care is potentially beneficial for improving cancer patient outcomes and quality of care. The authors developed a family involvement program (FIP) and in this study, the authors aim to evaluate the impact of the FIP on family caregiver burden and well-being. Moreover, the authors aim to assess the fidelity of the program.
Surgical interventions for intractable migraine: a systematic review and meta-analysis
Authors: Tahani Alrahbeni, Ahmed Mahal, Anas Alkhouri, Hadil Faris Alotaibi, Vineet Rajagopal, Ashish Behera, Khalid AL-Mugheed, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Quazi Syed Zahiruddin, Muhammed Shabil, Ganesh Bushi, Sarvesh Rustagi, Neelima Kukreti, Prakasini Satapathy, Ranjan K. Mohapatra, Arkadiusz Dziedzic, Bijaya Kumar Padhi
Journal: International Journal of Surgery (2024)

Background: Migraine affects ~14–15% of the global population, contributing to nearly 5% of the world’s health burden. When drug treatments prove ineffective for intractable migraines, highly specific surgical interventions emerge as potential solutions. The authors aimed to analyze surgical approaches for these refractory or intractable migraines through a systematic review and meta-analysis. Methods: The authors conducted a literature search across databases such as PubMed, Scopus, Web of Science, and Embase, focusing on studies related to migraines and surgical outcomes. The authors considered clinical trials or observational studies that included any surgical intervention for refractory or intractable migraines, emphasizing key outcomes such as reductions in migraine intensity, Migraine Disability Assessment scores (MIDAS), and 50% Migraine Headache Index (MHI) reduction rates. Statistical analyses were performed using R version 4.3. Results: Eleven studies were included in the systematic review. A meta-analysis of four studies involving overall 95 patients showed a significant reduction in mean migraine intensity scores using ONS (−2.27, 95% CI: −3.92 to −0.63, P =0.021). Three studies with 85 patients showed an average MIDAS score reduction of −52.3, though this was not statistically significant (95% CI: −136.85 to 32.19, P =0.116). Two additional studies corroborated these reductions in MIDAS scores. Nerve decompression surgery showed a substantial decrease in the average migraine intensity (from 8.31 down to 4.06). Median MIDAS score dropped from 57 to 20. Two studies indicated a success rate of 40 and 82%, respectively, in achieving a 50% reduction in the migraine MHI through nerve decompression. Findings from two studies suggest that septorhinoplasty and sinus surgery effectively decrease migraine intensity scores. Conclusion: The existing evidence emphasizes the potential advantages of surgical interventions as a promising approach to managing intractable or refractory migraines. However, robust and comprehensive research is crucial to refine and solidify the efficacy of these surgical methods, aiming for widespread benefits for patients, considering cost-effectiveness factors.
A different picture on liver biopsy
Authors: Ashley Barnabas, Rosa Miquel
Journal: Journal of Hepatology (2024)

A 32-year-old was referred to her local gastroenterologist for investigation of longstanding abnormal liver biochemistry. Her past medical history was of hepatic steatosis, pulmonary sarcoidosis and suspected ileal sarcoidosis. Sarcoidosis was in longstanding clinical remission. There was no relevant family history. She reported fatigue and myalgia. Her body mass index was 22, and physical examination was unremarkable. Labs showed a mildly elevated bilirubin, 35 μmol/L (normal range [NR] 3-20), mildly elevated ALT 51 U/L (NR 10-35) and total protein of 84 U/L (NR 60-80).
From the Editor’s Desk...
Authors: Patrizia Burra, Frank Tacke, Vlad Ratziu, Stefan Zeuzem, Bruno Sangro, Paolo Angeli
Journal: Journal of Hepatology (2024)

Metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced non-alcoholic fatty liver disease (NAFLD). However, given that MASLD requires at least one cardiometabolic risk factor, questions were raised as to whether new evidence would need to be generated for MASLD. In this issue, Younossi and coworkers compared the clinical profile and outcomes of NAFLD to MASLD using a tertiary-care NAFLD database and NHANES-III. Ninety-nine percent of included patients met MASLD criteria while 95% met MASLD criteria on BMI only.
Modeling Structural Elements and Functional Responses to Lymphatic‐Delivered Cues in a Murine Lymph Node on a Chip
Authors: Corrado Mazzaglia, Hafsa Munir, Iek Man Lei, Magda Gerigk, Yan Yan Shery Huang, Jacqueline D. Shields
Journal: Advanced Healthcare Materials (2024)

Lymph nodes (LNs) are organs of the immune system, critical for maintenance of homeostasis and initiation of immune responses, yet there are few models that accurately recapitulate LN functions in vitro. To tackle this issue, an engineered murine LN (eLN) has been developed, replicating key cellular components of the mouse LN; incorporating primary murine lymphocytes, fibroblastic reticular cells, and lymphatic endothelial cells. T and B cell compartments are incorporated within the eLN that mimic LN cortex and paracortex architectures. When challenged, the eLN elicits both robust inflammatory responses and antigen-specific immune activation, showing that the system can differentiate between non specific and antigen-specific stimulation and can be monitored in real time. Beyond immune responses, this model also enables interrogation of changes in stromal cells, thus permitting investigations of all LN cellular components in homeostasis and different disease settings, such as cancer. Here, how LN behavior can be influenced by murine melanoma-derived factors is presented. In conclusion, the eLN model presents a promising platform for in vitro study of LN biology that will enhance understanding of stromal and immune responses in the murine LN, and in doing so will enable development of novel therapeutic strategies to improve LN responses in disease.
Endothelial nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome regulation in atherosclerosis
Authors: Shuai Guo, Litao Wang, Kaixiang Cao, Ziling Li, Mingchuan Song, Shuqi Huang, Zou Li, Cailing Wang, Peiling Chen, Yong Wang, Xiaoyan Dai, Xianglin Chen, Xiaodong Fu, Du Feng, Jun He, Yuqing Huo, Yiming Xu
Journal: Cardiovascular Research (2024)

Abstract Aims The activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in endothelial cells (ECs) contributes to vascular inflammation in atherosclerosis. Considering the high glycolytic rate of ECs, we delineated whether and how glycolysis determines endothelial NLRP3 inflammasome activation in atherosclerosis. Methods and results Our results demonstrated a significant up-regulation of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a key regulator of glycolysis, in human and mouse atherosclerotic endothelium, which positively correlated with NLRP3 levels. Atherosclerotic stimuli up-regulated endothelial PFKFB3 expression via sterol regulatory element-binding protein 2 (SREBP2) transactivation. EC-selective haplodeficiency of Pfkfb3 in Apoe−/− mice resulted in reduced endothelial NLRP3 inflammasome activation and attenuation of atherogenesis. Mechanistic investigations revealed that PFKFB3-driven glycolysis increased the NADH content and induced oligomerization of C-terminal binding protein 1 (CtBP1), an NADH-sensitive transcriptional co-repressor. The monomer form, but not the oligomer form, of CtBP1 was found to associate with the transcriptional repressor Forkhead box P1 (FOXP1) and acted as a transrepressor of inflammasome components, including NLRP3, caspase-1, and interleukin-1β (IL-1β). Interfering with NADH-induced CtBP1 oligomerization restored its binding to FOXP1 and inhibited the glycolysis-dependent up-regulation of NLRP3, Caspase-1, and IL-1β. Additionally, EC-specific overexpression of NADH-insensitive CtBP1 alleviates atherosclerosis. Conclusion Our findings highlight the existence of a glycolysis-dependent NADH/CtBP/FOXP1-transrepression pathway that regulates endothelial NLRP3 inflammasome activation in atherogenesis. This pathway represents a potential target for selective PFKFB3 inhibitors or strategies aimed at disrupting CtBP1 oligomerization to modulate atherosclerosis.
A retrospective comparison of early- and late-onset chronic actinic dermatitis: characteristics and management
Authors: Chayada Chaiyabutr, Robert Dawe, Andrea Lesar, Sally H Ibbotson
Journal: British Journal of Dermatology (2024)

Our study highlights the high prevalence of early-onset chronic actinic dermatitis (CAD; age &amp;lt; 40 years at diagnosis), particularly in patients with atopic diseases and those with darker skin phototypes. Disease characteristics, photodiagnostic investigations and outcomes did not significantly differ between those with early-onset vs. late-onset disease, although younger patients more frequently required systemic therapy. We also show that marked UVA sensitivity and positive baseline series patch testing are negative prognostic factors for outcomes in CAD.
Letter to the Editor: On the use of nonselective beta-blockers in cirrhosis
Authors: Eric M. Przybyszewski, Irun Bhan, Joseph C. Yarze
Journal: Hepatology (2024)

Division of Gastroenterology and Hepatology, Massachusetts General Hospital, Boston, Massachusetts Abbreviations: clinically significant portal hypertension, CSPH; hepatic encephalopathy, HE; non-selective beta blocker, NSBB Correspondence Joseph C. Yarze. 55 Fruit St. Boston, MA 02114 617-726-2426. Email: [email protected]