tbuckley/cabot-search huggingface dataset:
Social support as a determinant of health-related quality of life in breast cancer survivors in California.
Authors: Faiza Rab
Journal: Journal of Clinical Oncology (2013)

118 Background: To evaluate the relationship between perceived social support and HRQOL (physical and emotional) in low SES (Socio economic status) breast cancer survivors. Methods: A cross-sectional study design was used to measure perceived social support at 18 months and HRQOL at 3 years after breast cancer diagnosis using MOS SS and MOS SF-36, respectively. Multiple regression analyses were used to evaluate the relationship. Results: Menopause at the time of diagnosis, adjunct chemotherapy, adjunct radiation therapy, co-morbidities, treatment side effects and depression were negatively associated with PCS scores (p &lt; 0.01). Treatment side effects, anxiety and depression were negatively associated with MCS scores (p &lt; 0.01). Conclusions: Perceived social support was not associated with HRQOL in low SES breast cancer survivors in our study. Menopause, co-morbidities, treatment side effect, adjunct chemotherapy and radiation therapy adversely affect physical HRQOL. Feelings of anxiety, depression and treatment side effects have a negative impact on emotional HRQOL.
MASSIVE RESPONSE TO A MERCURIAL DIURETIC IN A CASE OF CONGESTIVE HEART FAILURE
Authors: P H ROSS, S GRAU
Journal: Annals of Internal Medicine (1950)

Case Reports1 February 1950MASSIVE RESPONSE TO A MERCURIAL DIURETIC IN A CASE OF CONGESTIVE HEART FAILUREPHILIP H. ROSS, M.D., SIDNEY GRAU, M.D.PHILIP H. ROSS, M.D.Search for more papers by this author, SIDNEY GRAU, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-2-335 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe value of mercurial diuretics in the treatment of congestive heart failure is well known. Instances of remarkable response to this medication have been occasionally reported. We recently observed such a case, in which massive diuresis followed the use of mercuhydrin. In our patient the use of this drug produced a greater diuretic response than any heretofore reported in the American literature.CASE REPORTA 46 year old Negress was admitted to Michael Reese Hospital on August 5, 1947, with symptoms and signs of right heart failure, manifested chiefly by massive anasarca and moderate ascites. Her present illness dated from...Bibliography1. RussekZolman IHBL: The syndrome of Bernheim, Am. Heart J. 30: 437-441, 1945. CrossrefGoogle Scholar2. SpragueGraybiel HBA: Salyrgan as a diuretic, New England J. Med. 204: 154-157, 1931. CrossrefGoogle Scholar3. SteuerWolpaw LGSE: The diuretic action of mercupurin, J. Lab. and Clin. Med. 21: 298-300, 1935-1936. Google Scholar4. BarkerO'Hare MHJP: The use of salyrgan in edema, J. A. M. A. 91: 2060-2064, 1928. CrossrefGoogle Scholar5. StewartWheeler HJCH: The use of mercupurin in the treatment of congestive heart failure, Am. Heart J. 14: 536-539, 1937. CrossrefGoogle Scholar6. Wheeler CH: The use of diuretics—conference on therapy, New York State J. Med. 42: 1095, 1942. Google Scholar7. Wheeler CH: The use of mercurial diuretics—Cornell Conference, New York State J. Med. 46: 65, 1946. Google Scholar8. ModellGoldClarks WHDA: Quantitative observations on mercuhydrin and mercupurin, J. Pharmacol, and Exper. Therap. 84: 284-290, 1945. Google Scholar9. Ramsden G: Extreme response to a mercurial diuretic, Brit. M. J. 1: 1159, 1936. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PHILIP H. ROSS, M.D.; SIDNEY GRAU, M.D.Affiliations: Chicago, Illinois*Received for publication December 20, 1947.From the Medical Service of Dr. Matthew Taubenhaus, Michael Reese Hospital, Chicago. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1950Volume 32, Issue 2 Page: 335-338 Keywords Ascites Diuretics Drugs Edema Heart failure Medical services Signs and symptoms ePublished: 1 December 2008 Issue Published: 1 February 1950 PDF downloadLoading ...
Inflammatory Bowel Disease and<i>ADAM17</i>Deletion
Authors: Katharina Brandl, Wataru Tomisato, Bruce Beutler
Journal: New England Journal of Medicine (2012)

To the Editor: Blaydon et al. (Oct. 20 issue)1 identify a loss-of-function mutation in ADAM17 as a cause of inflammatory skin and bowel disease in two of three children born to consanguineous parents. We have previously reported an N-ethyl-Nnitrosourea–induced mutation in Adam17, producing a strong dextran sodium sulfate–induced colitis-susceptibility phenotype in mice.2 This mutant mouse (wavedX) was one among many with susceptibility to dextran sodium sulfate caused by monogenic mutations, identified in a panel of 6000 G3 (third-generation post-mutagenesis) animals screened for recessive phenotypes. Like its human counterparts, wavedX also had an epidermal abnormality. Histologic analysis of the guts of wavedX mice is normal without administration of dextran sodium sulfate. Similarly, in the siblings described by Blaydon and colleagues, a trigger was probably necessary to induce intestinal inflammation in early childhood. The study by Blaydon et al. validates forward genetic analysis in the mouse as a tool for identifying susceptibility loci in human inflammatory bowel disease, and it adds to the view that many cases of inflammatory bowel disease may be caused by single-gene mutations affecting any of a large number of target loci. Katharina Brandl, Ph.D.
Mutation-Enhanced International Prognostic Scoring System (MIPSS) for Primary Myelofibrosis: An AGIMM &amp; IWG-MRT Project
Authors: Alessandro Maria Vannucchi, Paola Guglielmelli, Giada Rotunno, Cristiana Pascutto, Animesh Pardanani, Virginia Ferretti, Annalisa Pacilli, Alessandro Pancrazzi, Terra Lasho, Curtis A Hanson, Rhett Ketterling, Naseema Gangat, Enrico Tagliafico, Rossella Manfredini, Valentina Artusi, Isabella Bernardis, Daniela Pietra, Elisa Rumi, Margherita Maffioli, Vittorio Rosti, Silvia Salmoiraghi, Federica Delaini, Alberto Bosi, Daniela Cilloni, Francisco Cervantes, Francesco Passamonti, Giovanni Barosi, Alessandro Rambaldi, Tiziano Barbui, Mario Cazzola, Ayalew Tefferi
Journal: Blood (2014)
Abstract 11039: Role of Blood Transfusion Product Type and Dose in Deep Vein Thrombosis (DVT) After Cardiac Surgery
Authors: Lama G Ghazi, Thomas A Schwann, Greg Kasper, Milo C Engoren, Robert H Habib
Journal: Circulation (2012)

Objective: Postoperative DVT is associated with significant morbidity and possibly death. We previously reported a 13% incidence of mostly silent DVT after cardiac surgery despite implementing maximal thromboprophylaxis, and that DVTs were predicted by increasing age, prolonged ventilation/no ambulation, and if transfusion occurred.This Transfusion-DVT association remains incompletely elucidated to date, and we hypothesized it will vary with product type and increase with transfusion dose. Methods: Detailed RBC, Platelets (PLT), FFP and Cryoprecipitate units (u) data were collected for 1070 cardiac surgery patients evaluated with serial postoperative duplex venous scans (DVS) until discharge. Incidence of DVT was studied for used blood type combinations and dose categories (ref = 0 units). Adjusted Odds Ratios [OR(95% confidence interval)] were derived via multivariate logistic regression. Results: DVT occurred in 139 (13%) patients. Transfusion was used in 506 (47%) patients: RBC [468 (44%); 4.0±4.2u]; F...
Abstract 2971: Managed Ventricular Pacing In Pediatric Patients And Patients With Congenital Heart Disease
Authors: Jonathan R Kaltman, Pamela Ro, Frank Zimmerman, Jeffrey P Moak, Michael Epstein, Ilana J Zeltser, Karen Buck, Maully J Shah, Victoria L Vetter, Ronn E Tanel
Journal: Circulation (2007)

Introduction: Ventricular dyssynchrony induced by ventricular pacing (VP) may predispose patients (pts) to congestive heart failure. The detrimental effects of VP are directly related to the cumulative percentage of VP (Cum%VP). Managed ventricular pacing (MVP, Medtronic) is a novel pacing algorithm developed to minimize unnecessary VP by uncoupling atrial pacing from VP. The use, efficacy, and safety of MVP in pediatrics pts and pts with congenital heart disease (CHD) have not been described. Methods: A multicenter review evaluated all pediatric pts &lt; 22 years old and older pts with CHD that had an implanted device using an MVP algorithm. Primary outcome variables were Cum%VP and adverse events. A subgroup analysis evaluated pts that had a DDD/R pacemaker prior to MVP device with similar low pacing rate and compared Cum%VP before and after initiation of MVP, using Wilcoxon signed-rank test. Results: 62 patients from 6 centers were included for the review (see table ). Mean age at MVP device implant was 21.5 ± 9.6 years (range 7–51). 63% of pts had CHD. With MVP device, mean Cum%VP was 4.3 ± 14.6% (range 0 – 83.7). By pacing indication, Cum%VP was 2.9 ± 6.5% in pts with sinus node dysfunction (n = 24), 34.8 ± 41.3% in pts with atrioventricular (AV) block (n = 5), and 0.6 ± 1.0% in pts with an ICD (n = 33). 11 patients were eligible for subgroup analysis. With DDD/R pacing, mean low rate was 64 ppm and mean paced/sensed AV intervals were 251 and 241 ms. With MVP, mean low rate was 63 ppm and mean paced/sensed AV intervals were 193 and 166 ms. Compared to DDD/R, Cum%VP significantly decreased with MVP (67.1 ± 29.4 vs. 9.2 ± 24.8%; p &lt; 0.005). One MVP-related adverse event occurred: a pt with intermittent AV block had symptoms with nonconducted atrial beats and was reprogrammed to DDD. Conclusions: MVP can be used safely and can significantly reduce unnecessary ventricular pacing in pediatric pts and pts with CHD. MVP should be considered when choosing a pacing mode for this pt population.
THE MECHANISM INVOLVED IN POLYNEURITIS AS EXEMPLIFIED BY POSTDIPHTHERITIC POLYNEURITIS
Authors: M R BROWN
Journal: Annals of Internal Medicine (1952)

Article1 March 1952THE MECHANISM INVOLVED IN POLYNEURITIS AS EXEMPLIFIED BY POSTDIPHTHERITIC POLYNEURITISMADELAINE RAY BROWN, F.A.C.P.MADELAINE RAY BROWN, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-3-786 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe toxin of the diphtheria bacillus offers the physician an unusual opportunity to observe the onset and march of signs in polyneuritis. The patient is in the hospital 10 days before the onset of palatal weakness and several weeks before the onset of paralysis of the limbs. Because the etiology of postdiphtheritic polyneuritis is known, a study of 53 such patients may shed light on the mechanism involved in 40 patients with a polyneuritis of unknown etiology but similar to the postdiphtheritic type in its clinical manifestations, spinal fluid and postmortem findings.Since 1943, diphtheria has increased steadily in Boston,...Bibliography1. Place EH: Diphtheria, in Oxford Medicine, vol. 5, Pt. 1, 1949, Oxford University Press, New York, 125-126. Google Scholar2. Pappenheimer AM: Diphtheria toxin: isolation and characterization of toxic protein from Corynebacterium diphtheriae filtrates, J. Biol. Chem. 120: 543-553, 1937. CrossrefGoogle Scholar3. Northrup JH: Purification of diphtheria antitoxin, Science 93: 92, 1941. CrossrefMedlineGoogle Scholar4. Feiner RR: Experimental diphtheritic paralysis, J. Immunol. 42: 273-289, 1941. Google Scholar5. CameronMuir JDEG: Cutaneous diphtheria in northern Palestine, Lancet 2: 720-723, 1942. CrossrefGoogle Scholar6. GaskillKorb HSM: Occurrence of multiple neuritis in cases of cutaneous diphtheria, Arch. Neurol. and Psychiat. 55: 559-572 (June) 1946. CrossrefMedlineGoogle Scholar7. ForsterBrownMerritt RMMRHH: Polyneuritis with facial diplegia, New England J. Med. 225: 51-56, 1941. CrossrefGoogle Scholar8. HaymakerKernohan WJW: The Landry-Guillain-Barré syndrome, Medicine 28: 59-141 (Feb.) 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication March 16, 1951.From the Department of Neurology, Harvard Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcute and Subacute NeuropathiesErkrankungen der peripheren Nerven 1 March 1952Volume 36, Issue 3Page: 786-791KeywordsBacillusDiphtheriaEtiologyNeurologyParalysisToxins ePublished: 1 December 2008 Issue Published: 1 March 1952 PDF downloadLoading ...
Abstract 15877: Abnormal T-Tubules, Calcium Cycling, and Cardiac Function During the Transition From Hypertension to Heart Failure: A Cell Attrition Model
Authors: J. A Wasserstrom, Deepak Gupta, Matthew J O'Toole, Amanda F Nahhas, James E Kelly, Satvik Ramakrishna, Nikhil Bassi, Nimi Chirayil, Sanjiv Shah, Gary L Aistrup
Journal: Circulation (2011)

INTRODUCTION: The cellular basis for the development of heart failure (HF) is not well understood. Disorganized t-tubules and the associated defects in Ca cycling are present in all types of HF. Ho...
Abstract 17192: 3T Myocardial Perfusion Imaging with Multitransmit Technology Compared to Coronary Angiography and FFR
Authors: Ullrich Ebersberger, Marcus R Makowski, Ulrich Platz, Johannes Rieber, Diethmar Antoni, Ellen Hoffmann, Alexander W Leber
Journal: Circulation (2011)

Background: Due to steady technical development cardiac magnetic resonance imaging has become a powerful tool to determine myocardial vitality, perfusion and function. In particular the new generation of 3T multitransmit MR scanner with higher field strength, better spatial resolution, improved homogeneity and a reduction of dielectric shading has the potential to increase the accuracy of first pass myocardial perfusion imaging. So far cardiac magnetic resonance perfusion imaging (CMRPI) on a 3T multitransmit MR scanner has not been evaluated against coronary angiography (CA) and/or measurements of the fractional flow reserve (FFR). Objective: To evaluate the predictive value of first pass perfusion MRI using 3T multitransmit technology in patients with significant and intermediate lesions using CA as well as FFR- measurements. Materials and Method: 111 patients with suspected coronary artery stenosis were investigated applying CMRPI on a 3T using multitransmission technology within ±5 days of CA. A high dose adenosine stress/rest perfusion protocol was used. After 3 minutes of adenosine infusion (170 µg · kg-1 · min-1 for 3 minutes), perfusion scans were performed (in-plane spatial resolution 2.97x 2.97mm, slice thickness 8mm; Achieva 3T Tx; Philips Healthcare; Netherlands). In patients with intermediate lesions (40-79%), FFR measurements (St. Jude; USA) were performed to assess functional relevance. Perfusion images were assessed visually. Interobserver disagreements were resolved by consensus in a joint session. Results: In 52 vessels revealing either a lesion &gt; 80% on CA or a pathological FFR (&lt; 0.75), adenosine induced stress perfusion deficits could be detected in 92 % (Sensitivity 92 %). In 281 vessels without pathological FFR or lesion &lt; 40 % a perfusion defect could be excluded in 98 % (specificity 98 %). Using ROC analysis, CMPRI was found highly accurate up to an FFR threshold of 0.77. Conclusion: Using 3T multitransmit technology we could demonstrate that CMPRI is an excellent tool to assess the functional relevance of significant and intermediate coronary stenosis with a high specificity and sensitivity. CMPRI was highly accurate up to an FFR threshold of 0.77.
Abstract 15483: FoxO1 Mediates an Auto-feedback Loop Regulation of SIRT1 Expression
Authors: Shiqin Xiong, Gloria Salazar, Nikolay Patrushev, R Wayne Alexander
Journal: Circulation (2010)

Forkhead transcription factor FoxO1 and the NAD + -dependent histone deacetylase SIRT1 are evolutionarily conserved regulators of the development of aging, oxidative stress resistance, insulin resistance, and metabolism regulation in species ranging from invertebrates to mammals. SIRT1 deacetylates FoxO1 and enables activation of FoxO1 transcription in multiple systems. The functional consequences of the interactions between FoxO1 and SIRT1 remain incompletely understood. Here, we demonstrate that the 1.5 kb rat SIRT1 promoter region contains a cluster of five putative FoxO1 core binding repeat motifs (designated IRS-1abcde, ACAAAAA, from -973 to -732) and a forkhead-like consensus binding site (designated FKHD-L, TATGTAAATA, from -370 to -361). Luciferase promoter assays demonstrate that FoxO1 directly activates SIRT1 promoter activity and that both the IRS-1 and FKHD-L enable FoxO1-dependent SIRT1 transcription. Electrophoretic mobility shift assays and chromatin immunoprecipitation assays show that FoxO1 binds to the IRS-1 and FKHD-L sites of the SIRT1 promoter  in vitro  and  in situ . Consistently, FoxO1 overexpression increases SIRT1 expression and FoxO1 depletion by siRNA reduces SIRT1 expression at both the messenger RNA and protein levels. Thus, endogenous FoxO1 is a positive transcriptional regulator of SIRT1 through the direct binding to the two  cis -acting elements in the SIRT1 promoter. Conversely, SIRT1 promotes FoxO1-driven SIRT1 auto-transcription through interacting with and deacetylating FoxO1. Moreover, resveratrol, a plant polyphenol activator of SIRT1, increases FoxO1-dependent SIRT1 transcription activity and thus induces its expression in rat vascular smooth muscle cells. These findings suggest that positive feedback mechanisms regulate FoxO1-dependent SIRT1 transcription and imputes a previously unappreciated function for FoxO1. The activity of this signaling network may sustain a variety of salutatory influences upon immune, inflammatory, regenerative, and metabolic processes that inform understanding of mechanistically related chronic diseases such as those associated with the metabolic syndrome.
US vaccine researcher is jailed for fraud
Authors: Michael McCarthy
Journal: BMJ (2015)

A vaccine researcher in the United States who admitted to fabricating and falsifying HIV vaccine research results has been sentenced to 57 months in prison and ordered to repay $7.2m (£4.6m; €6.5m) to the US National Institutes of Health (NIH), which funded much of his work.

The researcher, Dong-Pyou Han, pleaded guilty to the charges earlier this year. At the time of the fraud Han was a research assistant professor in the Department of Biomedical Services at Iowa State University of Science and Technology in Ames, Iowa.

An investigation conducted …
The General Practitioner and the Public Health Program
Authors: Felix J. Underwood
Journal: Annals of Internal Medicine (1931)

Article1 July 1931The General Practitioner and the Public Health ProgramFELIX J. UNDERWOOD, M.D., F.A.C.P.FELIX J. UNDERWOOD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-1-65 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is to the credit of our profession that its members have interested themselves actively in good government, and especially in those functions that have to do with the physical well-being of man and that involve applications of medical art and science both in the prevention and the cure of the diseases which afflict mankind.There is not a single point at which public health and private medicine cannot march forward in peace and good will. Our profession is traditionally committed to the prevention, as well as the cure, of disease. Out of its early labors arose the first slender... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Jackson, Mississippi Southern Medical Association*Delivered at the Baltimore Meeting of the American College of Physicians, March 24, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1931Volume 5, Issue 1Page: 65-69KeywordsPrevention, policy, and public health ePublished: 1 December 2008 Issue Published: 1 July 1931 PDF downloadLoading ...
Donor lymphocytes infusion in adult haplo-identical transplant: A dose finding study
Authors: Philippe Lewalle, Agnès Triffet, Alain Delforge, Caroline Jacquy, Michel Aoun, Redouane Rouas, Anne Sonnet, Hilde Demuynck, Fernand Ries, Dominique Bron, Philippe Martial
Journal: Blood (2001)
The prevalence of anxiety disorders in patients with chronic obstructive pulmonary disease
Authors: B Karajgi, A Rifkin, S Doddi, R Kolli
Journal: American Journal of Psychiatry (1990)

Fifty consecutive outpatients with stable chronic obstructive pulmonary disease were evaluated for lifetime prevalence of psychiatric morbidity. Eight percent had a diagnosis of panic disorder. This finding suggests that this patient population should be monitored for panic disorder.
Computed Tomographic Findings and Mortality in Patients With Pneumomediastinum From Blunt Trauma
Authors: Wayne S. Lee, Vincent E. Chong, Gregory P. Victorino
Journal: JAMA Surgery (2015)

The care of most patients with pneumomediastinum (PNM) due to trauma can be managed conservatively; however, owing to aerodigestive tract injury and other associated injuries, there is a subset of patients with PNM who are at higher risk of mortality but can be difficult to identify.To characterize computed tomographic (CT) findings associated with mortality in patients with PNM due to blunt trauma.A retrospective review of medical records from January 1, 2002, to December 31, 2011, was conducted at a university-based urban trauma center. The patients evaluated were those injured by blunt trauma and found to have PNM on initial chest CT scanning. Data analysis was performed July 2, 2013, to June 18, 2014.In-hospital mortality.During the study period, 3327 patients with blunt trauma underwent chest CT. Of these, 72 patients (2.2%) had PNM. Patients with PNM had higher Injury Severity Scores (P < .001) and chest Abbreviated Injury Scale scores (P < .001) compared with those without PNM. Pneumomediastinum was associated with higher mortality (9 [12.5%] vs 118 [3.6%] patients; P < .001) and longer mean (SD) hospital stays (11.3 [14.6] vs 5.1 [8.8] days; P < .001), intensive care unit stays (5.4 [10.2] vs 1.8 [5.7] days; P < .001), and ventilator days (1.7 [4.2] vs 0.6 [4.0] days; P < .03). We evaluated several chest CT findings that may have predictive value. Pneumomediastinum size was not associated with in-hospital mortality (P = .22). However, location of air in the posterior mediastinum was associated with increased mortality of 25% (7 of 28 patients; P = .007). Air in all mediastinal compartments was also associated with increased mortality of 40.0% (4 of 10 patients; P = .01). Presence of hemothorax along with PNM was associated with mortality of 22.2% (8 of 36 patients; P = .01).Pneumomediastinum is uncommon in patients with injury from blunt trauma; however, CT findings of posterior PNM, air in all mediastinal compartments, and concurrent hemothorax are associated with increased mortality. These CT findings could be used as a triage tool to alert the trauma surgeon to a potentially lethal injury.
Abstract 13389: Usefulness of Dual Induction Tests for Coronary Vasospasm and Ventricular Fibrillation for Individualized Treatment of Survivors from Out-of-Hospital Cardiac Arrest without Structural Heart Disease
Authors: Yusuke Takagi, Satoshi Yasuda, Jun Takahashi, Ryuji Tsuburaya, Yoshitaka Ito, Morihiko Takeda, Kenta Ito, Yuji Wakayama, Koji Fukuda, Masafumi Sugi, Hiroaki Shimokawa
Journal: Circulation (2010)