tbuckley/cabot-search huggingface dataset:
Abstract 2672: Serial in vivo Non-invasive Imaging of Intramyocardially Injected Autologous Mesenchymal Stem Cells, Modified for Transgene Expression of Positron-Emission Tomography (PET) Reporter in Porcine Myocardial Infarction
Authors: Mariann Gyongyosi, Jeronimo Blanco, Terez Marian, Ors Petnehazy, Rayyan Hemetsberger, Imre Pavo, Gusztav Font, Lajos Toth, Kurt Huber, Dietmar Glogar
Journal: Circulation (2007)

Objective. The aim of our study was to elaborate an in vivo tracking method of the intramyocardially injected msenchymal stem cells (MSCs), modified for transgene expression of trifusion protein (lentiviral vector, expressing renilla luciferase /RL/, red fluoroscein protein /RFP/ and herpes simplex truncated thymidine kinase /tTK, positron emmission tomography PET-reporter gene/) using serial PET imaging in pig myocardial infarction (MI). Methods. Bone marrow (100 ml) was harvested from pigs immediately before induction of MI by percutaneous balloon occlusion of the LAD followed by reperfusion. The MSCs were selected and cultivated. The lentiviral vector LV-RL-RFP-tTK was inoculated into the MSCs under control of CMV promoter. The cells with the highest fluorescence intensity (after achieving appr. 50% transfection efficacy) were sorted, and tracked in vitro by PET using 9-(4-[18F]fluoro-3-hydroxymethylbutyl)-guanine (18FHBG). The transfected MSCs (at least 3 mio MSCs/ pigs) were then injected direct intramyocardially using NOGA electromagnetic guidance in pigs in 10 locations of the infarct border zone (min. 0.3 million cells/injection), followed by PET imaging 30 hours and 7 days later, after intravenous injection of 5 mCi 18FHBG. Results. The in vitro 18FHBG uptakes of the transgene modified MSCs by PET were 10 times larger than the control JY human B-lymphoblasts and T lymphocytes. The minimum number of the cells detectable with PET was 0.2 million. MRI of the pigs revealed a mean global EF of 47+/-3.5%. PET imaging displayed diffuse distribution of the injected MSCs with high activity of the PET tracer in the anterior wall and septum at 30h, and less tracer activity in the injections sites with diffuse distribution in the pericardium and pleura indicating the wandering of the living cells at 7 days. PET imaging did not show 18FHBG accumulation in the infarcted heart of the control animals. Myocardial histology with RL and RFP staining confirmed the distribution of the injected MSCs through an elongated track around the injected area, 9 days after delivery. Conclusion. In vivo tracking of gene-modified porcine MSCs by PET imaging is feasible and allows serial noninvasive imaging of homing and propagation of MSCs in pigs after MI.
Benefit from dose-dense adjuvant chemotherapy for breast cancer: subgroup analyses from the randomised phase 3 PANTHER trial
Authors: Alexios Matikas, Andri Papakonstantinou, Sibylle Loibl, Günther G Steger, Michael Untch, Hemming Johansson, Nikos Tsiknakis, Mats Hellström, Richard Greil, Volker Möbus, Michael Gnant, Jonas Bergh, Theodoros Foukakis
Journal: The Lancet Regional Health - Europe (2024)
Reprogramming of iPSCs to NPCEC-like cells by biomimetic scaffolds for zonular fiber reconstruction
Authors: Tianhui Chen, Zhongxing Chen, Juan Du, Min Zhang, Zexu Chen, Qingyi Gao, Aodong Chen, Qinghao Meng, Yang Sun, Yan Liu, Linghao Song, Xinyue Wang, Pranav Prakash Edavi, Chen Xu, Hongmei Zhang, Jinhai Huang, Yongxiang Jiang
Journal: Bioactive Materials (2024)
Time trends in antithrombotic therapy during pregnancy and maternal and perinatal outcomes in the Netherlands (2013–19): a nationwide cohort study
Authors: Qingui Chen, Nienke van Rein, Lisa Broeders, Saskia Middeldorp, Kitty W M Bloemenkamp, Suzanne C Cannegieter, Luuk J J Scheres
Journal: The Lancet Haematology (2024)
Kazuyo Moro: Building relationships is essential for gaining both speed and opportunities in research
Authors: Montserrat Cols
Journal: The Journal of Experimental Medicine (2024)

Professor Kazuyo Moro holds dual appointments as a team leader for the Laboratory for Innate Immune Systems at RIKEN IMS as well as Osaka University Graduate School of Medicine. Her lab conducts multifaceted research on type 2 innate lymphoid cells (ILC2), from ILC2 differentiation, activation, suppression, and transcriptional control mechanisms, as well as basic research and drug discovery. The research from Prof. Moro lab aims to build new models and therapies for related immune diseases such as allergies, fibrosis, and metabolic diseases.
Haematopoietic gene therapy of non-conditioned patients with Fanconi anaemia-A: results from open-label phase 1/2 (FANCOLEN-1) and long-term clinical trials
Authors: Paula Río, Josune Zubicaray, Susana Navarro, Eva Gálvez, Rebeca Sánchez-Domínguez, Eileen Nicoletti, Elena Sebastián, Michael Rothe, Roser Pujol, Massimo Bogliolo, Philipp John-Neek, Antonella Lucía Bastone, Axel Schambach, Wei Wang, Manfred Schmidt, Lise Larcher, José C Segovia, Rosa M Yáñez, Omaira Alberquilla, Begoña Díez, María Fernández-García, Laura García-García, Manuel Ramírez, Anne Galy, Francois Lefrere, Marina Cavazzana, Thierry Leblanc, Nagore García de Andoin, Ricardo López-Almaraz, Albert Catalá, Jordi Barquinero, Sandra Rodríguez-Perales, Gayatri Rao, Jordi Surrallés, Jean Soulier, Cristina Díaz-de-Heredia, Jonathan D Schwartz, Julián Sevilla, Juan A Bueren
Journal: The Lancet (2024)
Predictors of pregnancy outcomes in SLE – Authors' reply
Authors: Merlijn Wind, Juan J Fierro, Kitty W M Bloemenkamp, Karina de Leeuw, A Titia Lely, Maarten Limper, Marieke Sueters, Y K Onno Teng, Isabel J Walter, Judith Kooiman
Journal: The Lancet Rheumatology (2024)
The impact of patient ethnicity on haematopoietic cell transplantation outcome: a retrospective cohort study on the UK experience
Authors: Neema P Mayor, Richard M Szydlo, Yasmin Sheikh, Julia Lee, Rachel M Pearce, Caitlin Farrow, Michaela Agapiou, Kanchan Rao, Kim Orchard, Eduardo Olavarria, Steven G E Marsh, John A Snowden
Journal: The Lancet Haematology (2024)
A horizon scan of biological conservation issues for 2025
Authors: William J Sutherland, Peter N M Brotherton, Holly M Butterworth, Stewart J Clarke, Tammy E Davies, Nigel Doar, Nafeesa Esmail, Erica Fleishman, Kevin J Gaston, James E Herbert-Read, Alice C Hughes, Jonathan Hughes, Hermanni Kaartokallio, Lian Pin Koh, Ritesh Kumar, Fiona A Lickorish, Hannah Littler, James E Palardy, James W Pearce-Higgins, Lloyd S Peck, Nathalie Pettorelli, Jules Pretty, Irene R Schloss, Mark D Spalding, Dirk Ten Brink, Eleanor R Tew, Anastasiya Timoshyna, Nicolas Tubbs, James E M Watson, Jonathan Wentworth, Jeremy D Wilson, Ann Thornton
Journal: Trends in Ecology & Evolution (2024)
Occupational Benzene Exposure and Lung Cancer in Human Studies: A Systematic Review and Meta-Analysis
Authors: Wenxin Wan, Susan Peters, Lützen Portengen, Ronnie Babigumira, Jo Steinson Stenehjem, David Richardson, Roel Vermeulen
Journal: Environmental Health Perspectives (2024)

Benzene is classified as carcinogenic to humans based on evidence that benzene causes acute myeloid leukemia. However, there is limited evidence that benzene causes lung cancer.
Author Correction: Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Authors: Carina Seah, Michael S. Breen, Tom Rusielewicz, Heather N. Bader, Changxin Xu, Christopher J. Hunter, Barry McCarthy, P. J. Michael Deans, Mitali Chattopadhyay, Jordan Goldberg, Saunil Dobariya, Frank Desarnaud, Iouri Makotkine, Janine D. Flory, Linda M. Bierer, Migle Staniskyte, Lauren Bauer, Katie Brenner, Geoff Buckley-Herd, Sean DesMarteau, Patrick Fenton, Peter Ferrarotto, Jenna Hall, Selwyn Jacob, Travis Kroeker, Gregory Lallos, Hector Martinez, Paul McCoy, Frederick J. Monsma, Dorota Moroziewicz, Reid Otto, Kathryn Reggio, Bruce Sun, Rebecca Tibbets, Dong Woo Shin, Hongyan Zhou, Matthew Zimmer, Scott A. Noggle, Laura M. Huckins, Daniel Paull, Kristen J. Brennand, Rachel Yehuda
Journal: Nature Neuroscience (2024)
Error in Figure
Journal: JAMA Cardiology (2024)

Megan Coylewright, MD, MPH; Kendra J. Grubb, MD, MHA; Suzanne V. Arnold, MD, MHA; Wayne Batchelor, MD, MHS; Abhijeet Dhoble, MD, MPH; Aaron Horne Jr, MD, MBA, MHS; Martin B. Leon, MD; Vinod Thourani, MD; Tamim M. Nazif, MD; Brian R. Lindman, MD, MSc; Molly Szerlip, MD
Sex Differences in Adverse Liver and Nonliver Outcomes in Steatotic Liver Disease
Authors: Taotao Yan, Xinrong Zhang, Tyler Wong, Ramsey Cheung, Mindie H. Nguyen
Journal: JAMA Network Open (2024)

This cohort study examines the association of sex with liver and nonliver adverse events using data from a US nationwide population-based database of patients with metabolic dysfunction–associated steatotic liver disease.
Nonemergency Medical Transportation Benefit in Traditional Medicare Advantage and Value-Based Plans
Authors: Yunrong Shen, Xin Hu, Ryan D. Nipp, K. Robin Yabroff, Arthur S. Hong, Joshua M. Liao, Changchuan Jiang
Journal: JAMA Network Open (2024)

This cross-sectional study examines differences in the provision of nonemergency medical transportation benefits between traditional and value-based Medicare plans.
Secure Messaging Use and Wrong-Patient Ordering Errors Among Inpatient Clinicians
Authors: Sunny S. Lou, Daphne Lew, Linlin Xia, Laura Baratta, Elise Eiden, Thomas Kannampallil
Journal: JAMA Network Open (2024)

Importance Use of secure messaging for clinician-to-clinician communication has increased exponentially over the past decade, but its association with clinician work is poorly understood. Objective To investigate the association between secure messaging use and wrong-patient ordering errors. Design, Setting, and Participants This cohort study included inpatient attending physicians, trainee physicians, and advanced practice practitioners (APPs) from 14 academic and community hospitals. Secure messaging volume was assessed over a 3-month period (February 1 to April 30, 2023). Exposure Secure messaging volume per clinician-day, measured as the count of secure messages sent and received by a clinician on a given clinician-day. Main Outcomes and Measures Retract-and-reorder events were used to identify wrong-patient ordering errors, and the presence of any retract-and-reorder event on a clinician-day was the primary outcome. Multilevel logistic regression was used to examine the association between secure messaging volume and wrong-patient ordering errors after adjusting for clinician age, sex, patient load, order volume, and clinical service. Results A total of 3239 clinicians (median [IQR] age, 37 [32-46] years; 1791 female [55.3%]; 1680 attending physicians [51.2%], 560 trainee physicians [17.3%], and 999 APPs [30.8%]) with 75 546 clinician-days were included. Median secure messaging volume was 16 (IQR, 0-61) messages per day. Retract-and-reorder events were identified on 295 clinician-days (0.4%). Clinicians with secure messaging volume at the 75th percentile had a 10% higher odds of wrong-patient ordering errors compared with those at the 25th percentile (odds ratio [OR], 1.10; 95% CI, 1.01-1.20). After stratifying by clinician role, the association between secure messaging and wrong-patient ordering errors was observed only for attending physicians (OR, 1.20; 95% CI, 1.02-1.42) and APPs (OR, 1.18; 95% CI, 1.00-1.40). Conclusions and Relevance In this cohort study of inpatient clinicians, higher daily secure messaging was associated with increased odds of wrong-patient ordering errors. Although messaging may increase cognitive load and risk for wrong-patient ordering errors, these results do not provide conclusive evidence regarding the direct impact of secure messaging on errors, as increased messaging may also reflect greater care coordination, increased patient complexity, or communication of the presence of a wrong-patient ordering error.
Psychological Interventions for Pediatric Posttraumatic Stress Disorder
Authors: Thole H. Hoppen, Lena Wessarges, Marvin Jehn, Julian Mutz, Ahlke Kip, Pascal Schlechter, Richard Meiser-Stedman, Nexhmedin Morina
Journal: JAMA Psychiatry (2024)

Importance Pediatric posttraumatic stress disorder (PTSD) is a common and debilitating mental disorder, yet a comprehensive network meta-analysis examining psychological interventions is lacking. Objective To synthesize all available evidence on psychological interventions for pediatric PTSD in a comprehensive systematic review and network meta-analysis. Data Sources PsycINFO, MEDLINE, Web of Science, and PTSDpubs were searched from inception to January 2, 2024, and 74 related systematic reviews were screened. Study Selection Two independent raters screened publications for eligibility. Inclusion criteria were randomized clinical trial (RCT) with at least 10 patients per arm examining a psychological intervention for pediatric PTSD compared to a control group in children and adolescents (19 years and younger) with full or subthreshold PTSD. Data Extraction and Synthesis PRISMA guidelines were followed to synthesize and present evidence. Two independent raters extracted data and assessed risk of bias with Cochrane criteria. Random-effects network meta-analyses were run. Main Outcome and Measures Standardized mean differences (Hedges g ) in PTSD severity. Results In total, 70 RCTs (N = 5528 patients) were included. Most RCTs (n = 52 [74%]) examined trauma-focused cognitive behavior therapies (TF-CBTs). At treatment end point, TF-CBTs ( g , 1.06; 95% CI, 0.86-1.26; P &amp;amp;lt; .001), eye movement desensitization and reprocessing (EMDR; g , 0.86; 95% CI, 0.54-1.18; P &amp;amp;lt; .001), multidisciplinary treatments (MDTs) ( g , 0.88; 95% CI, 0.53-1.23; P &amp;amp;lt; .001), and non–trauma-focused interventions ( g , 0.95; 95% CI, 0.62-1.28; P &amp;amp;lt; .001) were all associated with significantly larger reductions in pediatric PTSD than passive control conditions. TF-CBTs were associated with the largest short-term reductions in pediatric PTSD relative to both passive and active control conditions and across all sensitivity analyses. In a sensitivity analysis including only trials with parent involvement, TF-CBTs were associated with significantly larger reductions in pediatric PTSD than non–trauma-focused interventions ( g , 0.35; 95% CI, 0.04-0.66; P = .03). Results for midterm (up to 5 months posttreatment) and long-term data (6-24 months posttreatment) were similar. Conclusions and Relevance Results from this systematic review and network meta-analysis indicate that TF-CBTs were associated with significant reductions in pediatric PTSD in the short, mid, and long term. More long-term data are needed for EMDR, MDTs, and non–trauma-focused interventions. Results of TF-CBTs are encouraging, and disseminating these results may help reduce common treatment barriers by counteracting common misconceptions, such as the notion that TF-CBTs are harmful rather than helpful.
Symptom Recovery in Children Aged 5 to 12 Years With Sport-Related and Non–Sport-Related Concussion
Authors: Andrée-Anne Ledoux, Veronik Sicard, Vid Bijelic, Nick Barrowman, Jacqueline van Ierssel, Darcy Beer, Kathy Boutis, Emma Burns, William Craig, Stephen B. Freedman, Isabelle Gagnon, Jocelyn Gravel, Gurinder Sangha, Keith Owen Yeates, Martin Osmond, Roger Zemek
Journal: JAMA Network Open (2024)

Importance There is limited research on clinical features and symptom recovery from sport-related concussion (SRC) and non-SRC in younger children. Objective To investigate the trajectory of symptom recovery in children aged 5 to 7 years and 8 to 12 years with SRC and non-SRC at 1, 2, 4, 8, and 12 weeks postinjury. Design, Setting, and Participants This secondary analysis of a prospective multicenter cohort study (Predicting and Preventing Postconcussive Problems in Pediatrics) included participants aged 5 to 12 years with acute concussion who presented to 9 pediatric emergency departments within the Pediatric Emergency Research Canada network between August 2013 and June 2015. Analyses were conducted from September 2023 to May 2024. Exposure Participants had a concussion consistent with the Zurich consensus diagnostic criteria and 85% completeness of the Post-Concussion Symptom Inventory (PCSI) at each time point. Main Outcomes and Measures The primary outcome was symptom change, defined as current minus preinjury ratings 1, 2, 4, 8, and 12 weeks postinjury, measured using the PCSI. Symptoms were self-rated for children aged 8 to 12 years and child- and parent-rated for children aged 5 to 7 years. Mixed-effect models were conducted using total PCSI score adjusting for random effects; fixed-effect indicators included injury setting (SRC and non-SRC), time, injury setting × time, and other variables associated with recovery. Results A total of 1747 children, including 513 aged 5 to 7 years (mean [SD] age, 6.57 [0.85] years; 320 male [62.4%]) and 1234 aged 8 to 12 years (mean [SD] age, 10.68 [1.40] years; 806 male [65.3%]) were recruited, of whom 477 aged 5 to 7 years and 1157 aged 8 to 12 years were included in the analysis. Of those included in the analysis, 207 aged 5 to 7 years (43.4%; mean [SD] age, 6.68 [0.84] years; 142 male [68.6%]) and 790 aged 8 to 12 years (67.2%; mean [SD] age, 10.77 [1.40] years; 547 male [69.2%]) sustained an SRC. No significant differences in recovery curves across time postinjury were found between those with SRC and non-SRC (5-7 years: β = −0.09; 95% CI, −1.10 to 0.92; 8-12 years: β = 0.11; 95%CI, −1.50 to 1.70). Conclusions and Relevance In this cohort study of children aged 5 to 12 years with an acute SRC or non-SRC, symptom recovery trajectories over time were similar in both groups. This finding suggests similar management protocols can be used for sport and nonsport mechanisms of injury (excluding assault and motor vehicle crash) in the younger population.
Duration of Ice Hockey Play and Chronic Traumatic Encephalopathy
Authors: Bobak Abdolmohammadi, Fatima Tuz-Zahra, Madeline Uretsky, Raymond Nicks, Sydney Mosaheb, Jacob Labonte, Eukyung Yhang, Shruti Durape, Brett Martin, Joseph Palmisano, Christopher Nowinski, Jonathan D. Cherry, Victor E. Alvarez, Bertrand R. Huber, Kristen Dams-O’Connor, John Crary, Brigid Dwyer, Daniel H. Daneshvar, Lee E. Goldstein, Rhoda Au, Douglas I. Katz, Neil W. Kowall, Robert C. Cantu, Robert A. Stern, Michael L. Alosco, Thor D. Stein, Yorghos Tripodis, Ann C. McKee, Jesse Mez
Journal: JAMA Network Open (2024)

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHIs). Prior research suggests a dose-response association between American football play duration and CTE risk and severity, but this association has not been studied for ice hockey.
Axial Spondyloarthritis
Authors: Mohamad Bittar, Atul Deodhar
Journal: JAMA (2024)

Importance Axial spondyloarthritis is an immune-mediated inflammatory condition involving the sacroiliac joints, spine, and peripheral joints. It affects approximately 1% of adults in the US and is associated with impaired physical function and reduced quality of life. Observations Inflammatory chronic back pain characterized by gradual onset starting before age 45 years, prolonged morning stiffness, improvement with exercise, and lack of improvement with rest is the most common symptom of axial spondyloarthritis and affects more than 80% of patients. Patients with axial spondyloarthritis may also have inflammatory arthritis in large peripheral joints (most commonly knees) in an oligoarticular, asymmetric fashion; inflammation at tendon insertions (enthesitis); inflammatory eye disease (uveitis); psoriasis; and inflammatory bowel disease. The pathogenesis of axial spondyloarthritis may involve genetic predisposition, gut microbial dysbiosis, and entheseal trauma, with immune cell infiltration of the sacroiliac joints and entheseal insertion areas in the spine. There are currently no diagnostic criteria for axial spondyloarthritis. The diagnosis, often delayed 6 to 8 years after symptom onset, is based on history (ie, inflammatory back pain [sensitivity, 74%-81%; specificity, 25%-44%]), laboratory findings (human leukocyte antigen B27–positive [sensitivity, 50%; specificity, 90%] and elevated C-reactive protein level [sensitivity, 35%; specificity, 91%]), and imaging findings consisting of sacroiliitis on plain radiography (sensitivity, 66%; specificity, 68%) or magnetic resonance imaging (sensitivity, 78%; specificity, 88%). First-line treatments are physical therapy and nonsteroidal anti-inflammatory drugs (NSAIDs). However, less than 25% of patients achieve complete symptom control with NSAIDs. Approximately 75% of patients require biologic drugs (tumor necrosis factor inhibitors [anti-TNF agents], interleukin 17 inhibitors [anti–IL-17 agents]) or targeted synthetic disease-modifying antirheumatic agents (Janus kinase [JAK] inhibitors) to reduce symptoms, prevent structural damage, and improve quality of life. Clinical trials reported that anti-TNF agents significantly improved ASAS20 (measure of pain, function, and inflammation) in 58% to 64% of patients compared with 19% to 38% for placebo. Similar outcomes were attained with anti–IL-17 agents (48%-61%, vs 18%-29% with placebo) and JAK inhibitors (52%-56%, vs 26%-29% with placebo). Anti-TNF agents, anti–IL-17 agents, and JAK inhibitors have been associated with reduced radiographic progression of axial spondyloarthritis. Conclusions Axial spondyloarthritis predominantly affects the sacroiliac joints and spine but is also associated with extraskeletal manifestations such as uveitis, psoriasis, and inflammatory bowel disease. Physical therapy and NSAIDs are first-line treatments, but most patients require therapy with biologics (anti-TNF or anti–IL-17 agents) or JAK inhibitors to achieve improvement in signs and symptoms, inflammation control, and reduced progression of structural damage.
Accuracy in Measurement of Infant Formula Powder and Water by Caregivers With and Without a Crying Baby Present
Authors: Richard R. Rosenkranz, Chris Acosta, Ana Gonzalez-Alvarez, Andrew Hooyman, Jose R. Hidalgo, Romina Ballesteros-Paniagua, Sara K. Rosenkranz
Journal: JAMA Network Open (2024)

This cross-sectional study assesses the accuracy in measurement of powder and water when preparing infant formula in the presence or absence of a simulated crying baby.
Periarticular Cutaneous Nodules and Symmetric Polyarthralgia With an Insidious Onset
Authors: J. Alexander Sizemore, Maria Angelica Selim, Matilda W. Nicholas
Journal: JAMA Dermatology (2024)

A man in his early 50s presented to autoimmune dermatology clinic for 3 years of periarticular nodules on his fingers that were painful with manipulation or minor trauma and symmetric polyarthralgia. What is your diagnosis?