tbuckley/cabot-search huggingface dataset:
Abstract P086: Fried Food Consumption and Risk of Type 2 Diabetes and Coronary Heart Disease: Two Prospective Studies in US Men and Women
Authors: An Pan, Leah E Cahill, Stephanie E Chiuve, Qi Sun, Walter C Willett, Frank B Hu, Eric B Rimm
Journal: Circulation (2013)

Introduction: Through the processes of oxidation, polymerization, and hydrogenation, the cooking method of frying modifies both foods and their frying medium. However, it remains unknown whether frequent consumption of fried foods is related to long-term cardio-metabolic health. Therefore, we aimed to prospectively examine fried food consumption and risk of developing incident type 2 diabetes (T2D) or coronary heart disease (CHD). Methods: Fried food consumption was assessed by questionnaire among 71,281 women from the Nurses’ Health Study (1984-2008) and among 39,835 men from the Health Professionals Follow-up Study (1986-2008) who were free of diabetes, cardiovascular disease and cancer at baseline. Time-dependent Cox proportional hazards models were used to estimate the relative risks (RRs) and 95% confidence intervals (CIs) for T2D and CHD in each cohort, adjusted for demographic, diet, lifestyle and other cardio-metabolic risk factors. Results were pooled by inverse-variance-weighted random-effects meta-analysis. Results: We documented a total of 9452 incident T2D cases (6890 women and 2562 men) and 5296 incident CHD cases (2562 women and 2734 men). Compared to participants who consumed fried foods &lt; once/week, individuals who consumed fried foods 1-3, 4-6 and ≥7 times/week had a significantly higher risk of T2D, with RRs (95% CIs) of 1.13 (1.00-1.28), 1.38 (1.30-1.46), and 1.51 (1.36-1.67), respectively. The association was generally stronger for eating fried food away from home (RR 1.79 [95% CI 1.45-2.21] comparing ≥4 times/week vs. &lt; once/week) than eating fried food at home (corresponding RR 1.23 [95% CI 1.13-1.35]). For CHD the RRs (95% CIs) for eating fried food 1-3, 4-6 and ≥7 times per week were 1.05 (0.95-1.16), 1.18 (1.05-1.33), and 1.18 (1.02-1.36), respectively, compared to less than once per week. Eating fried food ≥4 times per week at home were associated with a higher risk of CHD (RR 1.17; 95% CI 1.04-1.32), but the association was not significant for eating fried food away from home (RR 1.10; 95% CI 0.92-1.32). When we included biennial measures of body mass index in the models as a potential mediator, all RRs were largely attenuated, albeit still significant for diabetes. Conclusions: Frequent fried food consumption was significantly positively associated with incident T2D while moderately related to incident CHD, and these associations were largely mediated by body weight. Further studies are still needed to confirm these results and elucidate whether habitual fried food consumption is a marker of unhealthy lifestyle or has a causal role in the development of T2D and CHD. Nevertheless, the present study has identified a risk factor for T2D and CHD that may be readily modifiable by lifestyle or cooking changes that lead to the consumption of less fried foods.
Abstract 2725: Cardiac Function and Calcium Handling in Mouse Hearts: Taking Genetic Strain Variability Into Account
Authors: Urszula Siedlecka, Adarsh Shah, Ajay Gandhi, Sara Abou Al-Saud, Magdi Yacoub, Cesare Terracciano
Journal: Circulation (2009)

Genetic background is an important factor in determining disease progression and response to therapy. However, this factor is rarely considered in studies using transgenic mice, where strain-specif...
Novel N-substituted Imidazole based non-ATP competitive MEK inhibitors as potential anticancer agents
Authors: Srinivasa Karra, Andreas Goutopoulos, Amanda Sutton, Nadia Brugger, John Zhang, Qihong Xu, Tony Arulanandam, Roustem Nabioullin, Adam Shutes, Wendy Zhang, Carolyn Hum, Zhaowen Luo, Xuliang Jiang, Sharad Magar, Brian Healey, Robert Murray, Peter Blume-Jensen, Steve Arkinstall, Claudio Giachetti, Lucia Golzio, Pamela Ferro, Paolo Marinelli, Rocco Cirillo, Jeff Shaw, Matthias Schwarz
Journal: Cancer Research (2007)

5411   MEK1 and MEK2 are key intracellular enzymes critically involved in conveying extracellular growth, differentiation, and survival-inducing stimuli. These dual-specificity kinases exhibit rather restricted substrate specificity, which make them attractive targets for drug development. The activation of MEK by the upstream Raf serine/threonine kinases leads to activation of ERK, ultimately resulting in activation of several signaling cascades that control cell proliferation, and differentiation. Upregulated activity of MEK and/or ERK occurs as a consequence of gain-of-function in Ras or Raf mutations, amongst others, and is the hall mark of many malignancies, including malignant melanoma, colorectal, and pancreatic cancers. In addition, there is accumulating evidence supporting the involvement of active MEK in inflammatory, immune, and neurological disorders. Several N-substituted imidazole analogues have been developed as potent non-ATP-competitive inhibitors of MEK to target these diseases.  In Vitro  and  in vivo  evaluation of these inhibitors will be discussed.
Health Care for Americans with Disabilities — 25 Years after the ADA
Authors: Georgina Peacock, Lisa I. Iezzoni, Thomas R. Harkin
Journal: New England Journal of Medicine (2015)

Interview with Dr. Georgina Peacock on improvements in care and access to services for people with disabilities and where more work is needed. (07:44)Download Some provisions of the Affordable Care Act should extend the advances made by the Americans with Disabilities Act, passed in 1990. But the persistence of health disparities and barriers to care for people with disabilities indicates that more remains to be done.
Clinical usefulness of the ablative margin assessed by magnetic resonance imaging with Gd-EOB-DTPA for radiofrequency ablation of hepatocellular carcinoma
Authors: Masahiko Koda, Shiho Tokunaga, Toshiaki Okamoto, Masanori Hodozuka, Kennichi Miyoshi, Manabu Kishina, Yuki Fujise, Jun Kato, Tomomitsu Matono, Takaaki Sugihara, Kenji Oyama, Keiko Hosho, Jun-ichi Okano, Yoshikazu Murawaki, Suguru Kakite, Eijiro Yamashita
Journal: Journal of Hepatology (2015)
Abstract 3338: Value of a Novel Index of Microcirculatory Resistance for Invasively Assessing Myocardial Viability After Primary Angioplasty in Acute Myocardial Infarction: Comparison With FDG-PET
Authors: Hong-Seok Lim, Seung-Jea Tahk, Myeong-Ho Yoon, Seong-Ill Woo, Woon-Jung Choi, Byung-Joo Choi, So-Yeon Choi, Gyo-Seung Hwang, Joon-Han Shin
Journal: Circulation (2007)

Background: Despite the prognostic importance of the status of coronary microcirculation, there has been lacking in comparative studies on the most reliable invasive measurement for assessing microvascular integrity and myocardial viability in AMI. We compared a novel Index of Microcirculatory Resistance(IMR) to intracoronary wire-based physiologic parameters for evaluating myocardial viability after primary percutaneous coronary intervention(PCI) in AMI. Methods: After successful primary stenting for 28 patients with AMI, Doppler-derived microvascular resistance index (MVRI) and phasic flow velocity patterns were evaluated. Using a pressure-temperature sensor-tipped coronary wire, thermodilution-derived CFR(CFR thermo ) and coronary wedge pressure(P cw ) were measured and the ratio of P cw and mean aortic pressure(P cw /P a ) was calculated, along with IMR, defined as the distal coronary pressure divided by the inverse of the hyperemic mean transit time. 18 F-fluorodeoxyglucose(FDG) PET was performed after primary PCI to evaluate myocardial viability by regional percentage uptake of FDG in infarct-related segments. Results: Among Doppler-derived parameters, regional FDG uptake showed nice correlation with hyperemic averaged peak velocity(r=0.561, p=0.002), hyperemic MVRI (r= −0.452, p=0.016) and baseline deceleration time of diastolic flow velocity (r=0.505, p=0.006). In the group of pressure-derived parameters CFR thermo , P cw /P a and IMR revealed good correlations with regional FDG uptake (r=0.487, p=0.016; r= −0.469, p=0.012; r= −0.656, p&lt;0.001, respectively). By the receiver operating characteristics curve analysis for prediction of myocardial viability, as defined by the 50% FDG-PET threshold value, the largest area under the curve was acquired by IMR and the best cut-off value of IMR for prediction of myocardial viability was 22U (sensitivity of 79%, specificity of 86% and accuracy of 81%). Conclusions: Wire-based coronary physiologic assessment is useful for the prediction of myocardial viability immediately after primary PCI. IMR, a novel index representing the microvascular integrity, is a reliable parameter for the invasive, on-site assessment of myocardial viability after primary PCI in AMI.
GRANULOMA INGUINALE IN THE UNITED STATES
Authors: Douglas Symmers, Albert D. Frost
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5160: Obesity is Related to Concentric Left Ventricular Hypertrophy: Results from the Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Evrim B Turkbey, Robyn L McClelland, Richard A Kronmal, Diane Bild, Gregory L Burke, Russell P Tracy, Linda Wilkins, Andrew Arai, David A Bluemke
Journal: Circulation (2008)

Obesity is a risk factor for cardiovascular disease but its association with left ventricular (LV) morphologic adaptations is debated because of obesity-associated co-morbidities. We evaluated the relationship of obesity to ventricular size and remodeling independent of other risk factors for LV hypertrophy. 5004 participants (age 45– 84 years; 52% female) of the MESA study free of clinical cardiovascular disease underwent cardiac MRI to assess LV size and function. The association of LV indices with measures of obesity, including fat mass (FM), body mass index (BMI) and waist circumference (WC), was determined using generalized additive models adjusted for established risk factors for LV hypertrophy and fat-free mass (FFM). FFM of participants was estimated based on height-weight models derived from bioelectrical impedance studies and FM was obtained by subtracting FFM from weight. LV mass and end diastolic volume were positively associated with FM, BMI and WC after adjustment for risk factors and FFM. For a given FFM, LV mass/volume ratio increased with FM up to approximately 50 kg FM (Figure ). Cardiac output and stroke volume were also positively associated with FM (slopes: CO 0.02 L/min per kg FM, SV 0.16 ml per kg FM, p&lt;0.001 for each). Ejection fraction showed no significant association with FM. The associations of fat mass to increased LV mass and LV mass/volume were similar in patients with and without obesity associated co-morbidities. Obesity is associated with concentric LV hypertrophy, marked by increased LV mass/volume ratio, increased cardiac output and preserved ejection fraction.
Plaque Characterization by Coronary Computed Tomography Angiography and the Likelihood of Acute Coronary Events in Mid-Term Follow-Up
Authors: Sadako Motoyama, Hajime Ito, Masayoshi Sarai, Takeshi Kondo, Hideki Kawai, Yasuomi Nagahara, Hiroto Harigaya, Shino Kan, Hirofumi Anno, Hiroshi Takahashi, Hiroyuki Naruse, Junichi Ishii, Harvey Hecht, Leslee J. Shaw, Yukio Ozaki, Jagat Narula
Journal: Journal of the American College of Cardiology (2015)
Open-Label Phase 2 Study Of The Bispecific T-Cell Engager (BiTE®) Blinatumomab In Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Authors: Andreas Viardot, Mariele Goebeler, Michael Pfreundschuh, Nicole Adrian, Martin Libicher, Evelyn Degenhard, Julia Stieglmaier, Alicia Zhang, Dirk Nagorsen, Ralf C. Bargou
Journal: Blood (2013)
Abstract 19086: Validation Against Laser Particular Velocity Imaging of a New Algorithm of Echo Contrast Tracking Based on Optical Flow Algorithm for Echo Piv Method.
Authors: Damien P Coisne, Clement Guerin, Mathieu Lugiez, Michel Menard, Carine Guivier, David Tane, Luc Christiaens
Journal: Circulation (2010)

Background: Like optical Particular Velocity Imaging (PIV) analysis, Echo-PIV (EPIV) is usually based on a crosscorrelation technique. Although preliminary studies have shown high spatial resolution, a small dynamic range limits this technique. We have recently described a new method based on Optical flow algorithm applied to corrected raw B mode backscattered images (digital format prior to scan conversion). We thought validate the accuracy of this method againts PIV to describe intraventricular complex flow fields in experimental conditions. Methods: In vitro model: Atrio-ventricular simulator with a bioprostheses in mitral position. Stroke volume range from 30 to 70 ml, Frame rate (FR) from 178 to 530 i/s. Echo contrast concentration was kept stable along the experimentation Mechanical index :0.21. Image processing. Pre-treatment (1) Removing noise through soft wavelet thresholding method. (2) Decomposition of echo-piv sequence into: (a) geometrical component, (b) textural component (b) and © noise. (3...
Abstract 3321: Gender Impacts Capillary Density and Skeletal Muscle Composition in Patients With Peripheral Arterial Disease
Authors: William S Jones, Brian D Duscha, Jennifer L Robbins, Amy J Aldrich, Judy G Regensteiner, William R Hiatt, Brian H Annex
Journal: Circulation (2007)

Background : Peripheral arterial disease (PAD) is a disorder characterized by impaired blood flow to the legs and maladaptive changes in the skeletal muscle. It is generally accepted that the skeletal muscle characteristics in patients with PAD include decreased capillary density and an altered percentage of oxidative myofibers. The scientific literature is conflicting, and it is based on studies with small sample size and older methodologies of skeletal muscle analysis. In addition, women are under-represented or not included at all in these studies. Hypothesis : We hypothesized that there would be differences in skeletal muscle composition in PAD patients compared to healthy controls. We further hypothesized that there would be gender differences in skeletal muscle composition in PAD patients versus healthy controls. Methods : Thirty -one patients with PAD and 31 age-, gender-, and activity-matched healthy controls underwent gastrocnemius muscle biopsy. Capillary density analysis and muscle fiber type determination were performed using immunohistochemistry techniques. Capillary density was measured as endothelial cells per muscle fiber and endothelial cells per area (mm 2 ). Results : There was no significant difference in capillary density in patients with PAD versus healthy controls when measured as endothelial cells per fiber (mean = 1.45 ± 0.43 vs. 1.50 ± 0.35, NS) or area (mean = 1.20 ± 0.29 vs. 1.29 ± 0.33, NS). There was also no difference in muscle fiber type composition between the groups. In the PAD cohort, capillary density was significantly lower in the men versus the women (mean = 1.36 ± 0.35 vs. 1.59 ± 0.51, p=0.005). In our cohort of women, there was no difference in capillary density in patients with PAD versus healthy controls (N=12). In men, capillary density was significantly lower in the PAD group versus healthy controls (N=19, mean = 1.09 ± 0.20 vs. 1.28 ± 0.34, p=0.043). Conclusions : Our data fail to confirm the belief that patients with PAD have a decreased capillary density and an altered percentage of oxidative myofibers. However, we did find that gender has an important impact on these characteristics. Further study of skeletal muscle composition in PAD may help to better understand the functional relevance of the gender differences.
Association of Helicobacter pylori infection with coronary heart disease
Authors: G. Y H Lip, R. Wise, G. Beevers
Journal: BMJ (1996)

mendation of the British National Formulary.Care in the community was started in different ways by non-government organisations-for example, through the indigenous midwife training in Sudan mentioned by Johnstone and McConnan' and the village health worker programmes in India.4Even paediatric hospital practice in Britain is catching up with that in developing countries.Not many years ago in Britain parents were accepted in children's wards with some reluctance, but in developing countries parents have always been expected to be with their children to help with feeding and simple treatments and even to act as human hot-water bottles.In nutrition rehabilitation units in various developing countries, parental participation had a double purpose5: as parents helped to prepare nutritious meals from local foods they received a practical training in nutrition.Parents of children in Britain who have been diagnosed recently as having a chronic disease such as diabetes or cystic fibrosis, that requires lifestyle management would benefit from more involvement during their child's stay in hospital.Bengoa's concept of rehabilitation, pioneered in Latin America, is the best way for parents to learn while being involved in the recovery process.'
Abstract 15650: The Effect of Perhexiline on Myocardial Protection during Coronary Artery Surgery: a Two-Centre Randomised Double-Blind Placebo-Controlled Trial
Authors: Nigel E Drury, Neil J Howell, Eshan L Senanayake, Melanie J Calvert, Michael E Lewis, Jorge G Mascaro, Ian C Wilson, Timothy R Graham, Stephen J Rooney, Nick Freemantle, Michael P Frenneaux, Domenico Pagano
Journal: Circulation (2011)

Objectives: Perhexiline is a metabolic modulator that is thought to inhibit mitochondrial carnitine palmitoyltransferase, reducing fatty acid metabolism and increasing carbohydrate utilisation. We ...
Network of "medical buddies" is needed
Authors: G. Bennet, B A Noble
Journal: BMJ (1997)

Rationing health careAllocating resources only to treating present dangers would ruin preventive health care and jeopardise future livesEditor-In his article on the objectives of the NHS John Harris argues that "there is a good principle that real and present dangers should be met before future and speculative ones." 1 Has he really thought about the implications of this?Immunisation, health promotion, and preventive interventions would all be swept away in favour of curative treatments.As the lives lost by such a shift in resources would be future lives and the people not identifiable beforehand, they would count for nothing.The state's obligation to protect the "citizen against threats to her life and liberty" only applies to immediate threats.Harris argues that the health budget should be larger, as if a larger budget will somehow allocate itself and obviate the need for choosing between competing alternatives.He also claims that health care (and he means curative care) should be afforded a high priority in the state budget.This presents a simple dilemma: should the state spend more on raising the income of impoverished families or on resources to provide more intensive care beds?Since raising the income of poor families has no impact on immediate threats to health, according to Harris we must clearly prefer spending more on providing more intensive care beds.Harris fails to recognise the first problem in identifying healthcare needs.If resources are not the immediate constraint on a healthcare system then rationing takes place on the basis of whether a need (or a want) can be legitimised as a healthcare need.In times of plenty the remit of formal health care expands.Harris seems to desire this process to continue.In wishing for more of our labour to be devoted to financing this end, he can see no cost or opportunity cost to the process.Am I alone in finding this naive?
Abstract 42: Cardiac Troponin and Extent of Coronary Artery Disease After Resuscitated Sudden Cardiac Arrest
Authors: Peter Radsel, Marko Noc
Journal: Circulation (2011)

Interpretation of cardiac troponin after resuscitated sudden cardiac arrest is often difficult because increased values may be caused by cardiac arrest, resuscitation procedures and concomitant myocardial infarction due to obstructive coronary disease. In the present study, we related peak cardiac troponin I (TnI), early postresuscitation electrocardiogram (ECG) and coronary anatomy obtained by urgent coronary angiography following reestablishment of spontaneous circulation (ROSC). Postresuscitation electrocardiogram (ECG) revealed STEMI in 183 patients of whom 179 had at least one obstructive lesion. In 66 patients with ECG patterns other than STEMI, 44 had obstructive coronary disease. As shown in table, peak troponin was much greater in STEMI than in no STEMI groups. Within no STEMI group, greater peak TnI was associated with presence of obstructive coronary artery disease. In conclusion, while great majority of patients with STEMI after ROSC have evidence of at least one obstructive lesion, increased levels of troponin in patients without STEMI indicate presence of at least one obstructive lesion and may thereby facilitate decision for coronary angiography if not performed already on admission.
Abstract 16200: Chronic Heart Failure in Ambulatory Outpatients and the Impact of Multiple Co-Morbidities on Survival
Authors: J. Malcolm Arnold, Andrew Ignaszewski, Jonathan Howlett, Marie-Helene Leblanc, Peter Liu, Annemarie Kaan, Shelley Zieroth, Sandy Baker, Djilali Hanzal, Gord Marchiori
Journal: Circulation (2011)

Heart failure (HF) is associated with premature mortality. 18,307 HF patients were referred to 26 specialized outpatient HF clinics between 1999-2010 and included HF with reduced and preserved card...
Abstract 14304: Feasibility of Automated Function Imaging Based on Myocardial Strain Echocardiography in Rats: A Study Using Myocardial Ischemia/Reperfusion Model with and without Adrenomedullin
Authors: Takeshi Dosono, Kasumi Masuda, Toshihiko Asanuma, Satoshi Nakatani
Journal: Circulation (2011)

Background: Automated function imaging (AFI) is a clinically useful tool providing a panoramic view of left ventricular (LV) contraction based on myocardial strain. However, few studies demonstrate...
Abstract 3053: Predictors of Restenosis After Treatment of Unprotected Left Main Trunk With Paclitaxel
Authors: Jose Antonio Fernandez-Diaz, Federico De Marco, Thierry Lefevre, Mario Araya, Andres Rosas Ramos, Yves Louvard, Alice Ohanessian, Olivier Darremont, Marc Silvestri, Marie-Claude Morice
Journal: Circulation (2006)
Undetected Large Aortopulmonary Window in an Adult
Authors: Pairoj Chattranukulchai, Sudarat Satitthummanid, Sarinya Puwanant, Suphot Srimahachota, Seri Singhatanadgige, Smonporn Boonyaratavej
Journal: Journal of the American College of Cardiology (2013)
Abstract 2798: Myocardial Titin Isoform Expression in Concentric and Eccentric Left Ventricular Remodeling
Authors: Loek van Heerebeek, Attila Borbely, Nazha Hamdani, Ines Falcao-Pires, Istvan Edes, Cristina Gavina, Adelino F Leite-Moreira, Ger J Stienen, Jolanda van der Velden, Walter J Paulus
Journal: Circulation (2007)

Titin lowers cardiac muscle stiffness through a shift in isoform expression from the stiff N2B isoform to the compliant N2BA isoform. In patients with eccentric LV remodeling due to dilated or isch...