tbuckley/cabot-search huggingface dataset:
Genetic variation in C-reactive protein and risk of colorectal polyps
Authors: Cornelia M. Ulrich, John Whitton, Justin Sibert, Jeannette Bigler, Elizabeth M. Poole, John D. Potter
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4600 

Introduction: C-reactive protein (CRP) is an acute phase protein secreted by the liver in response to inflammatory stimuli and is considered a non-specific marker of inflammation. Elevated serum CRP concentrations have been implicated in the development of cardiovascular disease and possibly colon cancer. Several polymorphisms in the CRP gene, in particular a tri-allelic SNP -390C>A>T, have been associated with differential CRP concentrations among healthy adults, with some evidence of their functional effects on CRP expression. Methods: The CRP gene has been systematically sequenced for polymorphisms in both European and African American populations. No non-synonymous polymorphisms have been identified to date. We used a linkage-disequilibrium-based tagSNP-selection algorithm at a threshold of r2 =0.80 and identified six tagSNPs representative of the overall genetic variation in Europeans (-821A>G, -390C>A>T 90A>T 838G>C 2043G>A and 4363C>A). In a Caucasian Minnesota-based case-control study of adenomatous (n=491) or hyperplastic (n=184) polyps vs. polyp-free controls (n=583) we investigated the role of these genetic variants in polyp risk, and potential modification of the association by NSAID use. Results: There were no statistically significant differences in adenoma or hyperplastic polyp risk associated with individual tagSNPs, with the exception of CRP 838G>C. Individuals with 838 GC or CC genotypes were at a somewhat increased risk of adenomas (OR=1.40 95% CI 0.94-2.08) and at a 2-fold increased risk of having both adenomas and hyperplastic polyps concurrently (OR=1.95 95% CI 1.06-3.58). Six haplotypes with frequencies >1% were defined by the tagSNPs. There were no significant associations between any of these haplotypes and risk of colorectal polyps when compared to the most common haplotype (GCAGGC) with odds ratios ranging from 0.88-1.20. We observed some evidence that the risk of adenomas associated with use of aspirin or other NSAIDs differed by CRP 838G>C genotype: Inverse associations with NSAID use were only observed among individuals wild type for 838GG (OR=0.64, 95% CI 0.48-0.85), whereas no risk reduction was observed among those with GC or CC genotypes (OR=1.05, 95% CI 0.59-1.85). However, this interaction was not statistically significant. Conclusions: These results provide limited support for an association between genetic variation in the CRP gene and risk of colorectal polyps. Larger studies are needed to define possible interactions with NSAID use.
Abstract 1690: Pre-Beta HDL and Lecithin:Cholesterol Acyltransferase Levels Are Strong Positive Diagnostic Risk Markers for Ischemic Heart Disease in Subjects with Both High and Low HDL-C Levels in the Copenhagen City Heart Study
Authors: Amar A Sethi, Maureen Sampson, Russel Warnick, Boerge G Nordestgaard, Anne Tybjaerg-Hansen, Alan T Remaley
Journal: Circulation (2008)

Objective: We hypothesize that patients with high HDL-C levels and Ischemic Heart Disease (IHD) may have dysfunctional HDL or unrecognized non-conventional risk factors. Methods: Subjects with IHD and either high HDL-C (n = 53; women:≥ 73.5mg/dL; men: ≥ 61.9mg/dL) or low HDL-C (n = 42; women: ≤ 38.7mg/dL; men: ≤ 34.1mg/dL) were compared with subjects without IHD and matched HDL-C levels (n = 110). All subjects had normal LDL-C (&lt; 160mg/dL) and triglyceride levels (&lt; 150mg/dL) and none were treated with lipid-lowering medications. Pre-beta HDL and Phospholipid Transfer Protein (PLTP) levels were measured using commercial kits and Lecithin:Cholesterol Acyltransferase (LCAT) activity, using a proteoliposome cholesterol esterification assay. Results: Pre-beta HDL levels were 2–3 fold higher in subjects with IHD in the high (p &lt; 0.0001) and low HDL-C (p = 0.001) groups. Interestingly, low LCAT activity was found in the same subjects with IHD and high (p = 0.002) or low (p = 0.03) HDL-C. Furthermore, higher PLTP levels were observed in the group with high HDL-C and IHD when compared to individuals without disease (p &lt; 0.0001). Receiver operating characteristic curve for pre-beta HDL in the high HDL-C groups yielded an area under curve of 0.71 for predicting IHD, which increased to 0.92 when LCAT values were included. Similar results were obtained for the low HDL-C groups. A strong inverse correlation between LCAT activity and pre-beta HDL-C ( r 2 = 0.30, p &lt; 0.0001), which was especially strong in the low HDL-C group ( r 2 = 0.56, p &lt; 0.0001) was observed. Individuals with high HDL-C and IHD had approximately 15% more apoA-I (p = 0.001) and apoA-II (p = 0.002) and nearly 10% more phospholipid (p = 0.007) than subjects with similar HDL-C and no IHD. Likewise, the group with low HDL-C had 30% more apoE (p = 0.035) and approximately 10% more phospholipid (p = 0.047) than the group with similar HDL-C levels and no IHD. Conclusions: IHD was associated with high pre-beta HDL and low LCAT levels. Measuring both gave correct classification in 92% of cases with IHD, thus making pre-beta HDL and LCAT activity a powerful diagnostic tool for IHD, particularly in commonly found patients wtih isolated low HDL-C levels with low to intermediate risk of IHD based on conventional risk factors.
Abstract 12390: Epicardial Implantation of Agarose Gel Patches Containing Adipose-Derived Stem Cells Improved Perfusion of Cryoinjury Infarction in Pig Hearts
Authors: Yanmin Yang, Patricia Dreessen de Gervai, Jiankang Sun, Miriam Glogowski, Eugene Gussakovsky, Valery Kupriyanov
Journal: Circulation (2010)
Web 2．0如何改变着医学：下一步是医学维基百科吗？
Authors: Dean, Giustini, 沈锡宾（译）
Journal: BMJ (2007)

在信息技术中“Web 2．0”可能是最让人感到混淆的概念。事实上即便是网络专家，也很难确切定义Web 2．0。类似“网络平台”或“分享结构”等含糊的短语常用来描述Web 2．0。医学图书馆员告诉我们，Web 2．0的意义不在于平台本身的益处，重要的在于其内在的开放共享和合作的精神。我们越是在网络上使用、共享和交换信息，不断的分析和提炼，这个平台就越具有开放性和创新性，越有利于我们的工作。
Abstract 12279: High Level of Plasma Remnant-like Particle Cholesterol in Normotensive Subjects May Predispose to Development of Hypertension
Authors: Akiko Kasahara, Hisashi Adachi, Yuji Hirai, Mika Enomoto, Ako Fukami, Maki Otsuka, Takanobu Miyamoto, Shun-ichi Kumagae, Yasuki Nanjo, Kuniko Yoshikawa, Eita Kumagai, Eishi Esaki, Kanako Yokoi, Kinuka Ogata, Eri Tsukagawa, Kyoko Ohbu, Tsutomu Imaizumi
Journal: Circulation (2011)

Objective:  Remnant-like particle cholesterol (RLP-c) is an atherogenic factor and associated with cardiovascular disease (CVD). RLP-c may induce endothelial dysfunction through oxidative mechanisms. The present study was designed to determine whether high plasma RLP-c levels predispose to the development of hypertension.   Design and Methods:  A total of 1,485 subjects (602 males and 883 females) aged over 40 years received a health examination in a Japanese Cohort of Seven Countries Study in 1999. We examined blood pressure (BP), body mass index (BMI), and blood chemistries including fasting RLP-c levels. The serum levels of RLP-c were measured by an immunoseparation method. We excluded 676 subjects from the analysis who had hypertension (BP≥140/90mmHg), were on antihypertensive medications, and/or on antihyperlipidemic medications at baseline. Ten years later, 681 subjects (248 males and 433 females) were re-examined (follow-up rate = 92%).   Results and Conclusion:  Of 681 normotensives at baseline, 303 subjects developed hypertension after 10 years. We divided the baseline plasma RLP-c levels into quartiles. The odds ratio for the development of hypertension after 10 years was 1.731 (95% confidence interval (CI): 1.062-2.821, p
Abstract 12431: Continuous Localized Monitoring of Plasmin Activity Identifies Differential and Regional Effects of the Serine Protease Inhibitor Aprotinin: Relevance to Antifibrinolytic Therapy
Authors: Daryl L Reust, Jennifer A Dixon, Richard A McKinney, Risha K Patel, William T Rivers, Rupak Mukherjee, Robert E Stroud, Scott T Reeves, James H Abernathy, Francis G Spinale
Journal: Circulation (2010)

Background: Antifibrinolytic therapy, such as the use of the serine protease inhibitor aprotinin, was a mainstay for hemostasis following cardiac surgery. However, aprotinin was empirically dosed, ...
The Relationship Between Renal Function and Cardiac Structure, Function, and Prognosis After Myocardial Infarction
Authors: Anil Verma, Nagesh S. Anavekar, Alessandra Meris, Jens Jakob Thune, J. Malcolm O. Arnold, Jalal K. Ghali, Eric J. Velazquez, John J.V. McMurray, Marc A. Pfeffer, Scott D. Solomon
Journal: Journal of the American College of Cardiology (2007)
Abstract 265: Therapeutic Hypothermia for Asystole/PEA Patients: A Tale of Guideline Non-Adherence or Therapeutic Success?
Authors: Shaker M Eid, Skon M Nazarian, Devon Dobrosielski, Scott M Carey, Joel M Palachuvattil, Kerry J Stewart, Nisha Chandra-Strobos
Journal: Circulation (2010)

AHA and ILCOR identified Therapeutic Hypothermia (TH) as a class I recommendation therapy for unconscious survivors of out-of-hospital cardiac arrest (OOHCA) presenting with ventricular fibrillatio...
Inhaled Carbon and Lung Function in Children
Authors: Nigel G Bruce, Mukesh K Dherani, Kirk R Smith
Journal: New England Journal of Medicine (2006)

To the Editor: Kulkarni and colleagues (July 6 issue) 1 found that the level of carbon in airway macrophages in children was strongly associated with expiratory flow rates, although in the 64 healthy children with sufficient numbers of airway macrophages for analysis, all these values were within generally acceptable normal limits. Why should this be? We suggest that this finding indicates that an accumulation of particles was a strong indicator of exposure to urban particulate air pollution and that exposure, in turn, is associated with chronic respiratory subclinical bronchiolitis. If so, we suggest that current exposures to urban pollution have to be taken very seriously.
Abstract 2523: Azelnidipine Enhances Beneficial Effects of Olmesartan on Left Ventricular Remodeling During the Development of Hypertension-induced Heart Failure
Authors: Xian Wu Cheng, Kenji Okumura, Kohzo Nagata, Aiko Inoue, Jie Zhang, Takao Nishizawa, Takashi Yamada, Yosuke Murase, Hideo Izawa, Hiroyuki Asano, Koji Obata, Masafumi Kuzuya, Guo-Ping Shi, Toyoaki Murohara, Mitsuhiro Yokota
Journal: Circulation (2007)

Objective: This work was undertaken to investigate the comparative effect of angiotensin II type 1 receptor blocker (ARB) and a combination of ARB and calcium channel blocker (CCB) on left ventricular (LV) remodeling during the development of hypertensive heart failure (H-HF). Methods and Results: We treated 8% salt-loaded Dahl salt-sensitive hypertensive rats (n = 10 for each group) with vehicle, hydralazine (5 mg/kg/d), olmesartan (OLM, 5 mg/kg/d), or combined OLM and azelnidipine (AZE, 2mg/kg/d) for 8 weeks. The rats fed 0.3% salt served as age-matched controls. The abundance of Cat mRNAs and proteins were localized in cardiac myocytes (CMCs), and Cat-dependent activities were increased by 4.1-fold in the LV of H-HF rats (n = 8, P&lt; 0.001) and were reduced by OLM treatment. OLM suppressed the elastic lamina degradation concomitant with decreased local Cat S expression in intracoronary smooth muscle cells (SMCs) and restored the balance of elastin to collagen in the LV tissue of H-HF rats (H-HF 4.6 ± 0.9% vs. OLM 15.5 ± 2.1% elastin content/collagen content (%), n = 6, P&lt; 0.0±1; control 22±2.1%). OLM suppressed not only macrophage infiltration but also levels of NADPH oxidase components (p22 phox , gp91 phox , and p47 phox ) concomitant with decreased NADPH activity and O2- production in LV tissues of H-HF rats. Along with its comparable anti-inflammatory effect, add-on AZE further improved all of these parameter changes by OLM. Furthermore, combination therapy significantly enhanced the improvement of LV fibrosis, hypertrophy, stiffness, and dysfunction by OLM. In vitro, H 2 O 2 stimulated Cat S mRNA and protein expression and activity, and these increases were abolished by pretreatment with the antioxidants such as MnTmPyp (50 μmol/L) and N-acetylcysteine (5 mmol/L) as well as a NADPH oxidase inhibitor apocynin (100 μmol/L) in culture CMCs, SMCs, and macrophages (n = 6, P&lt; 0.01). Conclusions: OLM and a combination of OLM and AZE exerted cardioprotective effects in hypertensive HF, via elastolytic Cat activation inhibition by the reduction of NADPH oxidase-dependent superoxide anion production. AZE enhanced the cardioprotective effects of OLM. Thus, the combination of ARB with CBB is a promising potential therapeutic strategy for H-HF.
Abstract 11910: The Systemic Inflammatory Response Syndrome is associated with Worse Outcomes in ST-Elevation Myocardial Infarction Patients: Insights from the CARDINAL Trial
Authors: Sean van Diepen, John P Vavalle, L. K Newby, Robert Clare, Karen S Pieper, Justin A Ezekowitz, Judith S Hochman, Kenneth W Mahaffey, Paul W Armstrong, Christopher B Granger
Journal: Circulation (2012)
Abstract 5535: In Vivo Activation Of Myocardial At2 Receptor Expression By Endogenous No And Pentaerythritol Tetranitrate
Authors: Thao-Vi V Dao, Vera Balz, Marc Oppermann, Tatsiana Suvorava, Georg Kojda
Journal: Circulation (2008)

There are many vascular signaling interactions between the vascular endothelial NO system and the renin-angiotensin-system. We hypothesized that endothelial NO might impact on the expression of angiotensin (AT) type 1 (AT1) and type 2 (AT2) receptors. We generated mice with an endothelial-specific overexpression of endothelial NO • -synthase (eNOS) using the Tie-2 promotor. Two of these lines were characterized by eNOS-Western blot analyses and blood pressure measurements in comparison to transgene negative controls. In addition, C57Bl/6 mice were fed with either 6 or 60 mg pentaerythritol tetranitrate (PETN) for 4 weeks and characterized as well. Analysis of line 1 of transgenic eNOS mice (1-eNOS) showed a 2.3±0.15 fold higher aortic expression of eNOS and a reduction of blood pressure to 109.6±2.0 mmHg (P&lt;0.01, n=4–6). Line 2 of transgenic eNOS mice (2-eNOS) showed a 3.3±0.3 fold higher aortic expression of eNOS and a reduction of blood pressure to 105.0±3.0 mmHg (n=6, P&lt;0.01). Treatment of 2-eNOS with the NOS-inhibitor L-nitroarginine (L-NAME) for 30 days inhibited the difference in blood pressure suggesting that this effect is due to increased bioavailability of endogenous nitric oxide (NO). In lungs and left ventricular myocardium of 2-eNOS the expression of AT1 receptors was similar to the controls (121.6±14.77%, and 100.1±12.43%, respectively, n=8, P&gt;0.05). In striking contrast, the expression of AT2 receptors was increased by endothelial overexpression of eNOS in a gene-dose-dependent manner in the myocardium. In 1-eNOS the increase was 134.3±10.66% (P&lt;0.05) and in 2-eNOS the increase was 177.7±20.93% (P&lt;0.05). In lung tissue the increase of AT2 receptor expression in line 2 amounted to 139.3±13.73% (P&lt;0.05) and to 131.8±.7 in line 1 of eNOS transgenic mice suggesting a vascular rather than a cardiomyocyte effect. Furthermore, preliminary experiments showed a significant increase of AT2 receptor expression in myocardial tissue of PETN-fed mice and a significant decrease in myocardial tissue of L-NAME-fed mice (respectively, n=4, P&lt;0.05). These results show that NO can upregulate vascular AT2 receptor expression in the lung and in the myocardium in-vivo. This newly discovered regulation might contribute to vasoprotective effects of NO.
血脂“正常”并非皆无需调脂治疗
Authors: 杨秉辉
Journal: BMJ (2008)

化验检查的结果，历来是疾病诊断的依据。有病自然应该治疗。所以化验的结果是否正常也就成了是否应该给予治疗的依据。这在大多数情况下是合乎情理的，但是情况也并非尽皆如此。脂代谢异常是心脑血管病的元凶，进行调脂治疗是预防心脑血管病的重要举措。血脂化验结果异常者当然需要治疗，正常者就不需要治疗了吗？答案需视具体情况而定。
Abstract 167: Barriers to Adoption of Postarrest Therapeutic Hypothermia and Methods to Increase Implementation
Authors: Audrey L Blewer, Marion Leary, Gail Delfin, David F Gaieski, Raina M Merchant, Lance B Becker, Benjamin S Abella
Journal: Circulation (2011)

Background: Post-arrest therapeutic hypothermia (TH) has been shown to dramatically improve outcomes after resuscitation, yet studies have revealed that TH adoption has been inconsistent and slow. Little is known about barriers to TH implementation and methods to increase adoption. Objective: We hypothesized that lack of education surrounding implementation is a more important barrier to TH adoption than lacking institutional leadership support or physician acceptance, and that an educational intervention might increase TH use. Methods: We administered mixed quantitative/qualitative surveys to clinicians before and after enrollment in a series of TH educational courses from 10/2009 to 7/2011, to determine usage and barriers to implementation. Six months post-training, self-reported clinician confidence and use of TH was assessed in the same cohort. Results: Clinicians completed 160 surveys (81 pre-training and 79 post-training). Of those, 74% were nurses, 24% were physicians; most represented ICU or ED practitioners. A ranking survey (score range 1-7; 7 as most important) found that lack of adequate staffing (mean score 4.5+2.1) and adequate education (4.4 + 1.6) were the two most emphasized barriers to TH implementation. Lacking institutional leadership support or physician acceptance was the least emphasized barrier (2.5+1.6, 3.3+2.0 respectively). Mean scores were significantly different between the expressed lack of adequate education and either institutional support or physician acceptance (p&lt;0.01, p=0.02, respectively). Post-survey results found that 96% of respondents felt more confident initiating TH post-educational intervention. There was a statistically significant increase in self-reported TH usage by surveyed clinicians after participation in our TH educational programs (p&lt;0.01). Conclusions: Practitioners highlighted lack of education surrounding TH implementation as a key barrier to TH use. A focused TH training course led to increased confidence and TH usage among participants. Future work will focus on targeted training to address specific barriers and increase appropriate TH utilization.
Rapid administration of multiple cycles of high-dose myelosuppressive chemotherapy in patients with metastatic breast cancer.
Authors: J Crown, A Kritz, L Vahdat, L Reich, M Moore, N Hamilton, J Schneider, M Harrison, T Gilewski, C Hudis
Journal: Journal of Clinical Oncology (1993)

PURPOSE To determine the feasibility and safety of a rapidly cycled sequence of high-dose myelosuppressive chemotherapy courses. PATIENTS AND METHODS Seventeen patients with metastatic breast cancer were treated with two courses of cyclophosphamide (CPA; 3.0 g/m2) supported by granulocyte colony-stimulating factor (G-CSF). Following the first CPA treatment, peripheral-blood leukaphereses commenced when the leukocyte count recovered to 1.0 x 10(9)/L. After hematologic recovery from the second dose of CPA, patients were treated with carboplatin 1,500 mg/m2, etoposide 1,200 mg/m2, and CPA 5.0 g/m2 administered over 3 days. The peripheral-blood progenitors (PBPs) were reinfused 3 days later, and G-CSF was recommenced. RESULTS All patients received the three courses. The median interval between treatments was 14 days (range, 13 to 21). Sixteen of the 34 courses of CPA resulted in admissions for fever. Following the third course, neutrophil counts recovered to 0.5 x 10(9)/L at a median of 9 days (range, 8 to 18) after PBP reinfusion and platelets recovered to 50 x 10(9)/L at a median of 12 days (range, 9 to 102). There were no treatment-related deaths. Flow-cytometric analysis was performed on the leukapheresis collections of eight patients. Seven patients with at least 2.0 x 10(6) CD34+ CD33- cells per kilogram body weight exhibited prompt hematologic recovery. One patient with 0.03 x 10(6) CD34+ CD33- cells was still cytopenic on day 21, and required reinfusion of her back-up marrow. Among seven patients with measurable or assessable disease, there were two complete responses (CRs) and four partial responses (PRs). CONCLUSION These preliminary results suggest that multiple, rapidly cycled courses of high-dose myelosuppressive chemotherapy can be administered. PBPs, harvested during the G-CSF-augmented rebound from CPA-induced cytopenia, produce rapid hematologic recovery in patients undergoing high-dose chemotherapy (HDC). Further follow-up will be necessary to assess the efficacy of this specific regimen in the treatment of metastatic breast cancer.
Abstract 15918: Comparison of Synthetic Small-Calibre Biodegradable vs. Stable ePTFE Vascular Prosthesis After Long-term Implantation in the Rat Aorta
Authors: Damiano Mugnai, Sarra de Valence, Wojciech Mrowczynski, Jean-Christophe Tille, Xavier Montet, Robert Gurny, Afksendiyos Kalangos, Michael Moeller, Beat H Walpoth
Journal: Circulation (2011)

Purpose: Shelf-ready, synthetic, small-calibre vascular prostheses are needed in cardiovascular surgery. We assessed the long term results of synthetic, biodegradable small-calibre vascular grafts ...
Abstract 1186: Asymmetric Dimethylarginine and HDL-cholesterol Independently Affect Arterial Wall Thickness in the First Decade of Life
Authors: Julian G Ayer, Guy Marks, Jason A Harmer, Olli T Raitakari, David S Celermajer
Journal: Circulation (2008)

Introduction The pathological changes of early atherosclerosis (fatty streaks and fibrous plaques) may be observed in the young and can be reflected in vivo by the carotid intima-media thickness (CIMT), measured by ultrasound. CIMT is a reliable marker of subclincal atherosclerosis in adults and traditional cardiovascular risk factors present in childhood predict CIMT in adulthood. However, the determinants of CIMT in childhood are largely unknown. We assessed the influence of traditional cardiovascular risk factors and also asymmetric dimethylarginine (ADMA, an endogenous inhibitor of nitric oxide synthesis) on CIMT, in healthy 8-year old children. Methods 406 community-based children (age 8.0±0.1, 49% girls) had anthropometry, systolic and diastolic blood pressure (SBP, DBP) and mean left and right CIMT measured. A non-fasting blood sample was collected for HDL, non-HDL cholesterol, apolipoprotein B (apo B), high sensitivity CRP (hs-CRP) and ADMA (measured by ELISA). Correlates of CIMT were evaluated. Results Mean (± sd) values were CIMT 0.59±0.06 mm, HDL 1.46±0.37 mmol/L, non-HDL cholesterol 2.96±0.70 mmol/L, apo B 0.64±0.15 mmol/L, and ADMA 0.91±0.22 μmol/L; median hs-CRP was 0.3 mg/L (interquartile range 0.21 to 1.09 mg/L). On univariate analysis, CIMT was associated significantly with SBP (r=0.164, p&lt;0.001), DBP (r=0.105, p&lt;0.017), HDL (r= −0.142, p&lt;0.006) and ADMA (r=0.182, p&lt;0.001). Measures of body size, apo B and hs-CRP were not significantly related to CIMT. On multivariable analysis, HDL (β coefficient = −0.118, p&lt;0.035) and ADMA (β coefficient = 0.175, p&lt;0.002) were significant independent determinants of CIMT in a model adjusted for all measured risk factors and sex. Conclusions Lower HDL-cholesterol and higher levels of ADMA, an endogenous inhibitor of nitric oxide synthesis, are significantly associated with CIMT in childhood. These data may permit earlier cardiovascular risk stratification and suggest novel mechanisms whereby HDL and ADMA might be modulating atherogenesis at an earlier stage than previously envisaged.
Abstract 2912: Circumferential, Radial and Longitudinal Strain Variations at Rest and During Dobutamine Infusion: Application of 2D Strain for Myocardial Ischemia Detection
Authors: Patricia Reant, Stephane Lafitte, Louis Labrousse, Karim Serri, Bertrand Beauvoit, Pierre Bordachar, Liliane Tariosse, Simone Bonoron-Adele, Claude Deville, Raymond Roudaut, Pierre Dos Santos
Journal: Circulation (2006)
Abstract 12288: Negative Impact of Protein-Energy Malnutrition on Long-Term Mortality in the Patients of Acute Decompensated Heart Failure
Authors: Masashi Fujino, Hiroyuki Takahama, Hideaki Kanzaki, Takashi Yamane, Taichi Adachi, Junichi Kotani, Masafumi Kitakaze, Hiroyuki Yokoyama
Journal: Circulation (2011)

Background: Protein-energy malnutrition (PEM) is rarely recognized in the setting of acute decompensated heart failure (ADHF). This study was aimed to investigate the impact of PEM on long-term pro...