tbuckley/cabot-search huggingface dataset:
Differences in Sentinel Node Biopsy and Targeted Axillary Dissection Following Neoadjuvant Chemotherapy—Reply
Authors: Giacomo Montagna, Monica Morrow, Walter P. Weber
Journal: JAMA Oncology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Payments by Drug and Medical Device Manufacturers to US Peer Reviewers of Major Medical Journals
Authors: David-Dan Nguyen, Anju Murayama, Anna-Lisa Nguyen, Alan Cheng, Liam Murad, Raj Satkunasivam, Christopher J. D. Wallis
Journal: JAMA (2024)

This study characterizes payments by drug and medical device manufacturers to US peer reviewers of major medical journals.
Staging and Prognosis of Nasopharyngeal Cancer
Authors: Sweet Ping Ng, Darrion Mitchell
Journal: JAMA Oncology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring
Authors: Yanji Qu, Xiaoqing Liu, Shao Lin, Michael S. Bloom, Ximeng Wang, Xiaohong Li, Hui Wang, Fengzhen Han, Ju-E. Liu, Weixiang Pan, Wangjian Zhang, Xia Zou, Jian Zhuang, Jie Li, Jimei Chen
Journal: JAMA Network Open (2024)

Importance The association of folate supplementation with congenital heart disease (CHD) prevention is controversial. Objective To examine the association of maternal serum folate levels at early to midpregnancy with CHD risk in offspring. Design, Setting, and Participants This case-control study recruited participants from one of China’s largest cardiac referral centers between 2015 and 2018. CHD cases and non-CHD controls were matched according to maternal age at a ratio of 1:4. Data were analyzed from May to August 2023. Exposures Maternal serum levels of folate, vitamin B 12 , and homocysteine were measured around the gestational age of 16 weeks. Main Outcomes and Measures The primary outcome was CHD, which was confirmed using echocardiography. The association between CHD risk in offspring with maternal folate levels was measured using adjusted odds ratios (aORs) with 95% CIs in conditional logistic regression analyses. Interactions between folate, vitamin B 12 , and homocysteine and CHD were estimated on a multiplicative scale. Results A total of 129 CHD cases with ventricular septal defect as the most common phenotype and 516 matched controls were included. The mean (SD) maternal age at pregnancy was 31.6 (5.3) years. There was a U-shaped association between maternal serum folate levels at early to midpregnancy and CHD risk in offspring. Compared with the offspring in the second and third quartiles of maternal folate, those in the lowest (aOR, 3.09; 95% CI, 1.88-5.08) and highest quartiles (OR, 1.81; 95% CI, 1.07-3.06) had increased odds of CHD. The ORs were higher when applying the World Health Organization criteria to determine the normal range for serum folate levels. Interaction analyses suggested that the adverse associations between low and high maternal folate and CHD risk might be further magnified by vitamin B 12 deficiency or elevated homocysteine. Conclusions and relevance In this case-control study of CHD, low maternal serum folate levels in early to midpregnancy were associated with an increased CHD risk in offspring, and excessively high folate levels were also associated with an elevated CHD risk. Further investigation is needed to make causal inferences for the observed associations and elucidate the underlying mechanisms.
The activity of tertiary lymphoid structures in high grade serous ovarian cancer is governed by site, stroma, and cellular interactions
Authors: Ian P MacFawn, Grant Magnon, Grace Gorecki, Sheryl Kunning, Rufiaat Rashid, Medard Ernest Kaiza, Huda Atiya, Ayana T Ruffin, Sarah Taylor, T Rinda Soong, Riyue Bao, Lan G Coffman, Tullia C Bruno
Journal: Cancer Cell (2024)
Public Awareness of Automated External Defibrillator Locations
Authors: Chien-Tai Huang, Chi-Hsin Chen, Chun-Hsiang Huang, Cheng-Yi Fan, Jiun-Wei Chen, Matthew Huei-Ming Ma, Edward Pei-Chuan Huang
Journal: JAMA Network Open (2024)

This cross-sectional study examines survey data from a 4-day nationwide telephone survey in Taiwan about awareness of and willingness to use automated external defibrillators.
C-Reactive Protein Induces Immunosuppression by Activating FcγR2B in Pulmonary Macrophages to Promote Lung Metastasis
Authors: Jun-Rui Feng, Xue Li, Cong Han, Yue Chang, Yu Fu, Gong-Chang Feng, Yutiantian Lei, Hai-Yun Li, Patrick Ming-Kuen Tang, Shang-Rong Ji, Yuzhu Hou, Yi Wu
Journal: Cancer Research (2024)

Abstract C-reactive protein (CRP) is a liver-derived acute phase reactant that is a clinical marker of inflammation associated with poor cancer prognosis. Elevated CRP levels are observed in many types of cancer and are associated with significantly increased risk of metastasis, suggesting that CRP could have pro-metastatic actions. Here, we reported that CRP promotes lung metastasis by dampening the anti-cancer capacity of pulmonary macrophages in breast cancer and melanoma. Deletion of CRP in mice inhibited lung metastasis of breast cancer and melanoma cells without significantly impacting tumor growth compared to wildtype mice. In addition, the lungs of CRP deficient mice were enriched for activated pulmonary macrophages, which could be reduced to the level of wildtype mice by systemic administration of human CRP. Mechanistically, CRP blocked the activation of pulmonary macrophages induced by commensal bacteria in a FcγR2B-dependent manner, thereby impairing macrophage-mediated immune surveillance to promote the formation of a pre-metastatic niche in the lungs of tumor-bearing mice. Accordingly, treatment with specific CRP inhibitors activated pulmonary macrophages and attenuated lung metastasis in vivo. These findings highlight the importance of CRP in lung metastasis, which may represent an effective therapeutic target for patients with advanced solid cancers in clinics.
Differences in Sentinel Node Biopsy and Targeted Axillary Dissection Following Neoadjuvant Chemotherapy
Authors: Mangesh A. Thorat
Journal: JAMA Oncology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Endogenous retroelements in hematological malignancies: From epigenetic dysregulation to therapeutic targeting
Authors: Mohamed Chour, Françoise Porteu, Stéphane Depil, Vincent Alcazer
Journal: American Journal of Hematology (2024)

Endogenous retroelements (EREs), which comprise half of the human genome, play a pivotal role in genome dynamics. Some EREs retained the ability to encode proteins, although most degenerated or served as a source for novel genes and regulatory elements during evolution. Despite ERE repression mechanisms developed to maintain genome stability, widespread pervasive ERE activation is observed in cancer including hematological malignancies. Challenging the perception of noncoding DNA as "junk," EREs are underestimated contributors to cancer driver mechanisms as well as antitumoral immunity by providing innate immune ligands and tumor antigens. This review highlights recent progress in understanding ERE co-option events in cancer and focuses on the controversial debate surrounding their causal role in shaping malignant phenotype. We provide insights into the rapidly evolving landscape of ERE research in hematological malignancies and their clinical implications in these cancers.
SpatialDeX is a Reference-Free Method for Cell Type Deconvolution of Spatial Transcriptomics Data in Solid Tumors
Authors: Xinyi Liu, Gongyu Tang, Yuhao Chen, Yuanxiang Li, Hua Li, Xiaowei Wang
Journal: Cancer Research (2024)

Abstract The rapid development of spatial transcriptomics (ST) technologies has enabled transcriptome-wide profiling of gene expression in tissue sections. Despite the emergence of single-cell resolution platforms, most ST sequencing studies still operate at a multi-cell resolution. Consequently, deconvolution of cell identities within the spatial spots has become imperative for characterizing cell type-specific spatial organization. To this end, we developed SpatialDeX, a regression model-based method for estimating cell type proportions in tumor ST spots. SpatialDeX exhibited comparable performance to reference-based methods and outperformed other reference-free methods with simulated ST data. Using experimental ST data, SpatialDeX demonstrated superior performance compared with both reference-based and reference-free approaches. Additionally, a pan-cancer clustering analysis on tumor spots identified by SpatialDeX unveiled distinct tumor progression mechanisms both within and across diverse cancer types. Overall, SpatialDeX is a valuable tool for unraveling the spatial cellular organization of tissues from ST data without requiring scRNA-seq references.
Heightened lateral habenula activity during stress produces brainwide and behavioral substrates of susceptibility
Authors: Anna Zhukovskaya, Christopher A. Zimmerman, Lindsay Willmore, Alejandro Pan-Vazquez, Sanjeev R. Janarthanan, Laura A. Lynch, Annegret L. Falkner, Ilana B. Witten
Journal: Neuron (2024)

Some individuals are susceptible to chronic stress, and others are more resilient. While many brain regions implicated in learning are dysregulated after stress, little is known about whether and how neural teaching signals during stress differ between susceptible and resilient individuals. Here, we seek to determine if activity in the lateral habenula (LHb), which encodes a negative teaching signal, differs between susceptible and resilient mice during stress to produce different outcomes. After (but not before) chronic social defeat stress, the LHb is active when susceptible mice are in proximity of the aggressor strain. During stress, activity is higher in susceptible mice during aggressor interactions, and activation biases mice toward susceptibility. This manipulation generates a persistent and widespread increase in the balance of subcortical vs. cortical activity in susceptible mice. Taken together, our results indicate that heightened activity in the LHb during stress produces lasting brainwide and behavioral substrates of susceptibility.
Precision Photothermal Therapy at Mild Temperature: NIR‐II Imaging‐Guided, H<sub>2</sub>O<sub>2</sub>‐Responsive Stealth Nanobomb
Authors: Gongcheng Ma, Qihang Ding, Yue Wang, Zhiwei Zhang, Yuding Zhang, Hui Shi, Lintao Cai, Ping Gong, Pengfei Zhang, Zhen Cheng, Jong Seung Kim
Journal: Advanced Healthcare Materials (2024)

The therapeutic efficacy of photothermal therapy (PTT) under mild temperatures (<45 °C) is hindered as cancer cells can activate heat shock proteins (HSPs) to mend fever-type cellular damage swiftly. The previous attempt fabricated first-generation nanobombs (nanobomb1G) by self-assembly of polymeric NIR-II AIEgens and carbon monoxide (CO) carrier polymer mPEG(CO) to inhibit the expression of HSPs after intratumor injection. A new generation nanobomb (Stealth NanoBomb (SNB)) is developed by self-assembling small molecular NIR-II AIEgens with CO carrier polymer PLGA(CO) coated by PEG-lipid. This design allows for intravenous administration, enabling the SNB to circulate safely in the bloodstream and selectively target cancer cells. Upon accumulation in tumors, the SNB releases CO to effectively suppress HSP expression, enhancing the therapeutic efficacy of mild-temperature PTT. Compared to the previous generation, the SNB offers a safer, more stable, and more efficient CO gas/drug co-delivery system for cancer treatment. This work represents a significant advancement in PTT, providing a promising strategy for enhanced antitumor therapy with reduced systemic toxicity.
Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion
Authors: Rei Kudo, Anton Safonov, Catherine Jones, Enrico Moiso, Jonathan R Dry, Hong Shao, Sharanya Nag, Edaise M da Silva, Selma Yeni Yildirim, Qing Li, Elizabeth O'Connell, Payal Patel, Marie Will, Atsushi Fushimi, Marimar Benitez, Martina Bradic, Li Fan, Harikrishna Nakshatri, Dhivya R Sudhan, Christopher R Denz, Iker Huerga Sanchez, Jorge S Reis-Filho, Shom Goel, Andrew Koff, Britta Weigelt, Qamar J Khan, Pedram Razavi, Sarat Chandarlapaty
Journal: Cancer Cell (2024)

Inhibition of CDK4/6 kinases has led to improved outcomes in breast cancer. Nevertheless, only a minority of patients experience long-term disease control. Using a large, clinically annotated cohort of patients with metastatic hormone receptor-positive (HR+) breast cancer, we identify TP53 loss (27.6%) and MDM2 amplification (6.4%) to be associated with lack of long-term disease control. Human breast cancer models reveal that p53 loss does not alter CDK4/6 activity or G1 blockade but instead promotes drug-insensitive p130 phosphorylation by CDK2. The persistence of phospho-p130 prevents DREAM complex assembly, enabling cell-cycle re-entry and tumor progression. Inhibitors of CDK2 can overcome p53 loss, leading to geroconversion and manifestation of senescence phenotypes. Complete inhibition of both CDK4/6 and CDK2 kinases appears to be necessary to facilitate long-term response across genomically diverse HR+ breast cancers.
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress
Authors: Lintao Song, Yushu Hou, Da Xu, Xijia Dai, Jianya Luo, Yi Liu, Zhuobing Huang, Miaomiao Yang, Jie Chen, Yue Hu, Chuchu Chen, Yuli Tang, Zhiheng Rao, Jianjia Ma, Minghua Zheng, Keqing Shi, Chao Cai, Mingqin Lu, Ruqi Tang, Xiong Ma, Cen Xie, Yongde Luo, Xiaokun Li, Zhifeng Huang
Journal: Cell Metabolism (2024)
Solitary Peritoneal Metastasis in Case of Osteosarcoma Detected by FDG PET/CT
Authors: Ujjwal Subedi, Raza Abbas Mahdi, Bhagwant Rai Mittal, Harmandeep Singh, Rajender Kumar, Vikas Bachhal
Journal: Clinical Nuclear Medicine (2024)

Abstract Primary osteosarcomas predominantly originate in the metaphyseal region of long bones. The introduction of 18 F-FDG PET/CT imaging has revealed unusual and often rare sites of metastatic spread. Peritoneal deposits in osteosarcoma are not a commonly reported finding in the literature. The present case highlights the 18 F-FDG PET/CT findings in a case of osteosarcoma of the left fibula with isolated peritoneal metastasis with no regional or distant metastases.
Hypertrophic Olivary Degeneration
Authors: Chandrasekaran Ganapathy, Madhavi Tripathi, Deula D’Cruz, Rakesh Lodha, Atin Kumar, Saumya Pandey, CS Bal
Journal: Clinical Nuclear Medicine (2024)

Abstract We present a case of 12-year-old boy evaluated in view of refractory ascites in whom 18 F-FDG PET/CT incidentally revealed hypermetabolism in the medulla that was proven to be hypertrophic olivary degeneration on MRI.
Physiological Gallbladder Accumulation on 68Ga-FAPI-46 PET/CT
Authors: Ömer Faruk Şahin, Göksel Alçın, Nurhan Ergül, Tevfik Fikret Çermik, Esra Arslan
Journal: Clinical Nuclear Medicine (2024)

Radiolabeled fibroblast activation protein inhibitors (FAPIs) are a novel approach in cancer detection and treatment. Targeting fibroblast activation protein, extensively produced by cancer-associated fibroblasts, FAPI plays a key role in tumor development. Its advanced imaging capabilities offer clearer results in solid tumors compared with traditional methods, drawing significant interest in oncology. Additionally, FAPI's activity in conditions requiring tissue remodeling, such as atherosclerosis and arthritis, highlights its broader potential. This interesting image shows the physiological accumulation of 68 Ga-FAPI in the gallbladder, emphasizing the importance of accurate interpretation to prevent misdiagnoses and ensure effective patient management.
Focal Pancreatitis Mimicking Neuroendocrine Tumor on DOTATATE PET/CT With Radiology-Pathology Correlation
Authors: Lasya Daggumati, Samuel J. Ballentine, Tyler J. Fraum
Journal: Clinical Nuclear Medicine (2024)

Abstract A 54-year-old man presented with left lower quadrant pain. CT showed no cause for his pain but identified an incidental 2.0-cm enhancing lesion in the pancreatic tail. On MRI, this lesion was hyperenhancing and diffusion-restricting, suspicious for a neuroendocrine tumor. However, EUS-guided biopsy yielded only benign pancreatic tissue. Due to this discordance, 64 Cu-DOTATATE PET/CT was performed. The pancreatic tail lesion was tracer-avid, suggesting a well-differentiated neuroendocrine tumor. Based on the PET findings, the patient underwent distal pancreatectomy. Surgical pathology revealed only focal chronic pancreatitis with islet aggregation, a previously undescribed mimic of neuroendocrine tumor on DOTATATE PET/CT.
Post-TACE FDG Accumulation in HCC Surrounding the Liver Parenchyma
Authors: Mirei Abe, Yoshitaka Toyama, Akitoshi Sano, Kentaro Takanami, Kei Takase
Journal: Clinical Nuclear Medicine (2024)

An 80-year-old patient with hepatocellular carcinoma (HCC) underwent an 18 F-FDG PET/CT scan owing to suspected lumbar metastasis identified via a CT scan performed during transarterial chemoembolization (TACE) 2 weeks earlier. The PET scan revealed segmental high uptake in the HCC and surrounding liver parenchyma, where lipiodol deposited during TACE had mostly washed out. The segmental uptake was attributed to TACE-induced inflammatory changes in the liver parenchyma around the HCC, confirmed by reduced uptake in a follow-up 18 F-FDG PET/CT scan 4 months later. This highlights the need to differentiate between inflammation and viable HCC in post-TACE 18 F-FDG PET/CT evaluations.
Upstaging of Invasive Lobular Cancer With FES PET/CT
Authors: Saud Rehman, Christine E. Edmonds, David A Mankoff, Austin R. Pantel, Sophia R. O’Brien
Journal: Clinical Nuclear Medicine (2024)

A 78-year-old woman diagnosed with left breast invasive lobular carcinoma with left axillary nodal metastasis underwent 18 F-fluoroestradiol (FES) PET/CT imaging for further evaluation of indeterminate right axillary lymph nodes seen on staging 18 F-FDG PET/CT. 18 F-FES PET/CT revealed abnormal 18 F-FES-avid right axillary and bilateral cervical nodes, subsequently biopsy-proven metastases, upstaging the patient from stage II to IV and greatly changing patient management. This case demonstrates the value of 18 F-FES PET/CT in accurately staging metastatic invasive lobular carcinoma at diagnosis, an indication for which 18 F-FES PET/CT "may be appropriate" per current Society of Nuclear Medicine and Molecular Imaging guidelines.
Breast Metastasis From Sigmoid Adenocarcinoma Revealed by FDG PET/CT
Authors: Yanlin Liu, Hongyuan Dai, Minggang Su, Rui Huang
Journal: Clinical Nuclear Medicine (2024)

Abstract Breast metastasis from sigmoid carcinoma is rare. A 32-year-old woman, who had a history of sigmoid carcinoma, was found a hypermetabolic soft tissue mass in the left breast and a lymph node with moderate uptake on FDG PET/CT. Final pathology supported that the breast mass and lymph node were both metastases from the sigmoid carcinoma.
Efficacy of Amniotic Membrane Grafting for the Treatment of Chemical and Thermal Ocular Surface Injuries
Authors: Peter B. Veldman, Mark A. Greiner, Maria S. Cortina, Anthony N. Kuo, Jennifer Y. Li, Darby D. Miller, Roni M. Shtein, Mitchell P. Weikert, Jia Yin, Stephen J. Kim, Joanne F. Shen
Journal: Ophthalmology (2024)
FDG Uptake in Brown Adipose Tissue Activated by a Long-Acting β2-Adrenergic Receptor Agonist Inhaler Prescribed for Bronchial Asthma
Authors: Akira Nitta, Tomoya Kotani, Chio Okuyama
Journal: Clinical Nuclear Medicine (2024)

We herein report a case of an elderly woman in whom brown adipose tissue (BAT) was visible on 18 F-FDG PET imaging performed in the summer. In this patient, none of the well-known factors that induce BAT activation in adults, including cold exposure, catecholamine-producing tumors, or β3-adrenergic receptor agonists administration, were present. Daily inhalation of a long-acting β2-adrenergic agonist for treatment of her bronchial asthma was considered the cause of her BAT visualization. This case suggests the need to consider β2-adrenergic receptor agonists as a cause of BAT visualization.
Diffusely Increased FDG Uptake of the Kidney Caused by Severe Renal Artery Stenosis
Authors: Benzheng Jiao, Liping Yang, Xiaobo Ma, Aisheng Dong, Hongguang Zhao
Journal: Clinical Nuclear Medicine (2024)

Renal artery stenosis can result in renovascular hypertension and ischemic nephropathy. We describe FDG PET/CT and delayed abdominal FDG PET/MRI findings in a kidney associated with severe renal artery stenosis resulting from renal artery invasion in retroperitoneal alveolar echinococcosis. The renal parenchyma showed diffusely increased activity on both FDG PET/CT and delayed FDG PET/MRI. There was no activity in the renal collecting system on FDG PET/CT and focal urine activity in the renal calyces on delayed FDG PET/MRI. This case indicates that renal artery stenosis should be included in the differential diagnosis of diffuse renal parenchymal FDG uptake.