tbuckley/cabot-search huggingface dataset:
Echocardiographer-guided Transjugular 3D ICE in combination with TEE enhances the image quality during tricuspid valve repair procedures
Authors: Massimiliano Mariani, Michela Bonanni, Rachele Manzo, Rosangela Capasso, Luigi Emilio Pastormerlo, Marcello Ravani, Tommaso Gasbarri, Umberto Paradossi, Sergio Berti
Journal:  (2024)
Oncolytic immunotherapy with nivolumab in muscle-invasive bladder cancer: a phase 1b trial
Authors: Roger Li, Nancy Y. Villa, Xiaoqing Yu, Joseph O. Johnson, Gustavo Borjas, Jasreman Dhillon, Carlos M. Moran-Segura, Youngchul Kim, Natasha Francis, Denise Dorman, John J. Powers, Wade J. Sexton, Philippe E. Spiess, Michael A. Poch, Logan Zemp, Scott M. Gilbert, Jingsong Zhang, Julio M. Pow-Sang, Alexander R. A. Anderson, Tingyi Li, Xuefeng Wang, G. Daniel Grass, James M. Burke, Colin P. N. Dinney, Paulo C. Rodriguez, Rohit K. Jain, James J. Mulé, Jose R. Conejo-Garcia
Journal: Nature Medicine (2024)
Differentiating Seborrheic Keratosis from Melanoma Among Lesions Exhibiting Blue-White Veil: A Retrospective Study
Authors: Isabella N. Dana, Nicholas R. Kurtansky, Larissa M. Pastore, James R. Xu, Zaeem H. Nazir, Stephen W. Dusza, Emmanouil Chousakos, Ofer Reiter, Cristian Navarrete-Dechent, Ralph P. Braun, Harold S. Rabinovitz, Ashfaq A. Marghoob
Journal: Journal of the American Academy of Dermatology (2024)
Timeline and outcomes of viral and fungal infections after Chimeric Antigen Receptor (CAR) T-cell therapy: A large database analysis
Authors: Joseph Sassine, Nelson Iván Agudelo Higuita, Emily A. Siegrist, Arman Saeedi, Michaele Francesco Corbisiero, Patrick Connelly, Alfonso G. Bastias, Rita Wilson Dib, José Henao-Cordero, Daniel B. Chastain, Chia-Yu Chiu, Andrés F. Henao-Martínez
Journal: Clinical Microbiology and Infection (2024)
Zebrafish patient-derived xenograft system for predicting carboplatin resistance and metastasis of ovarian cancer
Authors: Feifeng Song, Xiaofen Yi, Xiaowei Zheng, Zhentao Zhang, Linqian Zhao, Yan Shen, Ye Zhi, Ting Liu, Xiaozhen Liu, Tong Xu, Xiaoping Hu, Yiwen Zhang, Huafeng Shou, Ping Huang
Journal: Drug Resistance Updates (2024)

Ovarian cancer (OC) remains a significant challenge in oncology due to high rates of drug resistance and disease relapse following standard treatment with surgery and platinum-based chemotherapy. Despite the widespread use of these treatments, no effective biomarkers currently exist to identify which patients will respond favorably to therapy. This study introduces a zebrafish patient-derived xenograft (PDX) system, capable of replicating both the carboplatin response and metastatic behavior observed in OC patients, within a rapid 3-day assay period.
SpotCheck: A Skin Cancer Diagnostic Accuracy Study Comparing Teledermoscopy with and without Electrical Impedance Spectroscopy to In-Person Dermatologist Evaluation of Patient-Identified Lesions Concerning them for Skin Cancer
Authors: Jenne P. Ingrassia, Shirin Bajaj, Avani Kolla, Vivienne Li, Payal Shah, Nicholas Gulati, Maressa C. Criscito, Yiping Xing, Adriana Lopez, Duy C. Tran, Vignesh Ramachandran, Efe Kakpovbia, Shane Meehan, Yongzhao Shao, Kristen Lo Sicco, Emily C. Milam, Amy K. Bieber, Amanda Levine, Tracey N. Liebman, Jennifer A. Stein, David Polsky
Journal: Journal of the American Academy of Dermatology (2024)
Regulatory T Cells Engineered with Polyphenol-Functionalized Immunosuppressant Nanocomplexes for Rebuilding Periodontal Hard Tissue under Inflammation-Challenged Microenvironment
Authors: Bo Zhang, Guidong Gong, Yunxiang He, Jialing Liu, Bo Wang, Yifei Li, Jie Fang, Zhihe Zhao, Junling Guo
Journal: Biomaterials (2024)
Impact of an intranasal L-DBF vaccine on the gut microbiota in young and elderly mice
Authors: Ti Lu, Aaron C. Ericsson, Zackary K. Dietz, Alexa K. Cato, Lyndon M. Coghill, William D. Picking, Wendy L. Picking
Journal: Gut Microbes (2024)

spp. cause bacillary dysentery (shigellosis) with high morbidity and mortality in low- and middle-income countries. Infection occurs through the fecal-oral route and can be devastating for vulnerable populations, including infants and the elderly. These bacteria invade host cells using a type III secretion system (T3SS). No licensed vaccine yet exists for shigellosis, but we have generated a recombinant fusion protein, L-DBF, combining the T3SS needle tip protein (IpaD), translocator protein (IpaB), and the LTA1 subunit of enterotoxigenic
Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus
Authors: Shengnan Huang, Fangfang Li, Chunhua Quan, Dan Jin
Journal: Gut Microbes (2024)

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by destruction of pancreatic β-cells, leading to insulin deficiency and hyperglycemia, and its incidence is increasing year by year. The pathogenesis of T1DM is complex, mainly including genetic and environmental factors. Intestinal flora is the largest microbial community in the human body and plays a very important role in human health and disease. In recent years, more and more studies have shown that intestinal flora and its metabolites, as an environmental factor, regulate the development of T1DM through various mechanisms such as altering the intestinal mucosal barrier, influencing insulin secretion and body immune regulation. Intestinal flora transplantation, probiotic supplementation, and other approaches to modulate the intestinal flora appear to be potential therapeutic approaches for T1DM. This article reviews the dysbiosis of the intestinal flora in T1DM, the potential mechanisms by which the intestinal flora affects T1DM, as well as discusses potential approaches to treating T1DM by intervening in the intestinal flora.
Post-marketing surveillance of anticancer drugs using natural language processing of electronic medical records
Authors: Yoshimasa Kawazoe, Kiminori Shimamoto, Tomohisa Seki, Masami Tsuchiya, Emiko Shinohara, Shuntaro Yada, Shoko Wakamiya, Shungo Imai, Satoko Hori, Eiji Aramaki
Journal: npj Digital Medicine (2024)

This study demonstrates that adverse events (AEs) extracted using natural language processing (NLP) from clinical texts reflect the known frequencies of AEs associated with anticancer drugs. Using data from 44,502 cancer patients at a single hospital, we identified cases prescribed anticancer drugs (platinum, PLT; taxane, TAX; pyrimidine, PYA) and compared them to non-treatment (NTx) group using propensity score matching. Over 365 days, AEs (peripheral neuropathy, PN; oral mucositis, OM; taste abnormality, TA; appetite loss, AL) were extracted from clinical text using an NLP tool. The hazard ratios (HRs) for the anticancer drugs were: PN, 1.15-1.95; OM, 3.11-3.85; TA, 3.48-4.71; and AL, 1.98-3.84; the HRs were significantly higher than that of the NTx group. Sensitivity analysis revealed that the HR for TA may have been underestimated; however, the remaining three types of AEs extracted from clinical text by NLP were consistently associated with the three anticancer drugs.
Synthetic circRNA therapeutics: innovations, strategies, and future horizons
Authors: Jingsheng Cai, Zonghao Qiu, William Chi‐Shing Cho, Zheng Liu, Shaoyi Chen, Haoran Li, Kezhong Chen, Yun Li, Chijian Zuo, Mantang Qiu
Journal: MedComm (2024)

Abstract Small molecule drugs are increasingly emerging as innovative and effective treatments for various diseases, with mRNA therapeutics being a notable representative. The success of COVID‐19 vaccines has underscored the transformative potential of mRNA in RNA therapeutics. Within the RNA family, there is another unique type known as circRNA. This single‐stranded closed‐loop RNA molecule offers notable advantages over mRNA, including enhanced stability and prolonged protein expression, which may significantly impact therapeutic strategies. Furthermore, circRNA plays a pivotal role in the pathogenesis of various diseases, such as cancers, autoimmune disorders, and cardiovascular diseases, making it a promising clinical intervention target. Despite these benefits, the application of circRNA in clinical settings remains underexplored. This review provides a comprehensive overview of the current state of synthetic circRNA therapeutics, focusing on its synthesis, optimization, delivery, and diverse applications. It also addresses the challenges impeding the advancement of circRNA therapeutics from bench to bedside. By summarizing these aspects, the review aims to equip researchers with insights into the ongoing developments and future directions in circRNA therapeutics. Highlighting both the progress and the existing gaps in circRNA research, this review offers valuable perspectives for advancing the field and guiding future investigations.
Circulating tumor DNA methylation detection as biomarker and its application in tumor liquid biopsy: advances and challenges
Authors: Lingyu Li, Yingli Sun
Journal: MedComm (2024)

Abstract Circulating tumor DNA (ctDNA) methylation, an innovative liquid biopsy biomarker, has emerged as a promising tool in early cancer diagnosis, monitoring, and prognosis prediction. As a noninvasive approach, liquid biopsy overcomes the limitations of traditional tissue biopsy. Among various biomarkers, ctDNA methylation has garnered significant attention due to its high specificity and early detection capability across diverse cancer types. Despite its immense potential, the clinical application of ctDNA methylation faces substantial challenges pertaining to sensitivity, specificity, and standardization. In this review, we begin by introducing the basic biology and common detection techniques of ctDNA methylation. We then explore recent advancements and the challenges faced in the clinical application of ctDNA methylation in liquid biopsies. This includes progress in early screening and diagnosis, identification of clinical molecular subtypes, monitoring of recurrence and minimal residual disease (MRD), prediction of treatment response and prognosis, assessment of tumor burden, and determination of tissue origin. Finally, we discuss the future perspectives and challenges of ctDNA methylation detection in clinical applications. This comprehensive overview underscores the vital role of ctDNA methylation in enhancing cancer diagnostic accuracy, personalizing treatments, and effectively monitoring disease progression, providing valuable insights for future research and clinical practice.
Full‐active pharmaceutical ingredient nanosensitizer for augmented photoimmunotherapy by synergistic mitochondria targeting and immunogenic death inducing
Authors: Xianghui Li, Haoran Wang, Zhiyan Li, Song Liu, Yuanyuan Chen, Zhuren Ruan, Zhijian Yao, Gao Wei, Cunwei Cao, Wenjun Zheng, Wenxian Guan
Journal: MedComm (2024)

Abstract The precise and effective activation of the immune response is crucial in promising therapy curing cancer. Photoimmunotherapy (PIT) is an emerging strategy for precise regulation and highly spatiotemporal selectivity. However, this approach faces a significant challenge due to the off‐target effect and the immunosuppressive microenvironment. To address this challenge, a nanoscale full‐active pharmaceutical ingredient (API) photo‐immune stimulator was developed. This formulation overcomes the limitations of PIT by strengthening the ability to penetrate tumors deeply and inducing precise and potent mitochondria‐targeted dual‐mode photodynamic therapy and photothermal therapy. Along with inhibiting overexpressed Hsp90, this nanosensitizer in turn improves the immunosuppressive microenvironment. Ultimately, this mitochondria‐targeted PIT demonstrated potent antitumor efficacy, achieving a remarkable inhibition rate of ≥95% for both established primary tumors and distant abscopal tumors. In conclusion, this novel self‐delivery full‐API nanosystem enhances the efficacy of phototherapy and reprograms the immunosuppressive microenvironment, thereby holding great promise in the development of precise and effective immunotherapy.
Short‐course subcutaneous treatment with birch pollen allergoids greatly improves symptom and medication scores in birch allergy
Authors: Ralph Mösges, Esther Raskopf, Ludger Klimek, Oliver Pfaar, Stefan Zielen, Elena Xenofontos, Lea Decker, Christian Neuhof, Anna Rybachuk, Cengizhan Acikel, Hacer Sahin, Silke Allekotte, Sandra del Pozo Collado, José Luis Subiza, Miguel Casanovas, Mandy Cuevas
Journal: Allergy (2024)

Subcutaneous immunotherapy has emerged as an effective option for treating allergic diseases. Here, we assessed the clinical impact of the mannan-conjugated birch pollen polymerized allergoid T502 in birch pollen-induced allergic rhinoconjunctivitis.
Efficacy of subsequent therapies in patients with advanced ovarian cancer who relapse after first-line olaparib maintenance: results of the PAOLA-1/ENGOT-ov25 trial
Authors: P. Harter, C. Marth, M.-A. Mouret-Reynier, C. Cropet, D. Lorusso, E.M. Guerra-Alía, T. Matsumoto, I. Vergote, N. Colombo, J. Mäenpää, C. Lebreton, N. de Gregorio, A.M. Mosconi, M.J. Rubio-Pérez, H. Bourgeois, P.A. Fasching, S.C. Cecere, A.-C. Hardy-Bessard, D. Denschlag, S. de Percin, L. Hanker, L. Favier, D. Bauerschlag, C. Desauw, P. Hillemanns, R. Largillier, J. Sehouli, J. Grenier, E. Pujade-Lauraine, I. Ray-Coquard
Journal: Annals of Oncology (2024)

Use of first-line PARP inhibitor maintenance therapy is increasing in advanced ovarian cancer. Understanding the efficacy of first subsequent therapy (FST) in patients experiencing disease progression in the first-line setting is important to optimize post-progression treatments. We evaluated the efficacy of FST in patients from PAOLA-1/ENGOT-ov25 (NCT02477644) who received first-line olaparib maintenance.
Can we use viral receptor mapping and particle deposition models to predict the clinical severity of novel airborne pathogens?
Authors: Kineshta Pillay, Linsey C. Marr, Andre Henriques, Andrew R. Martin, Aaron J. Prussin, Luis Aleixo, Marco Andreini, Nicolas Mounet, Warren H. Finlay, Julian W. Tang
Journal: Clinical Microbiology and Infection (2024)
Pathogen and host determinants of extrapulmonary tuberculosis among 1035 patients in Frankfurt am Main, Germany, 2008-2023
Authors: Natalia Rachwal, Raja Idris, Viola Dreyer, Elvira Richter, Thomas A. Wichelhaus, Stefan Niemann, Nils Wetzstein, Udo Götsch
Journal: Clinical Microbiology and Infection (2024)

Extrapulmonary tuberculosis (EPTB) presents with nonspecific symptoms which can pose a significant diagnostic challenge. Various factors, including age, sex, and HIV status, have been associated with an increased risk of developing EPTB. However, the influence of the lineage of the infecting Mycobacterium tuberculosis complex (Mtbc) strain remains controversial.
Biologics and airway remodeling in asthma: early, late, and potential preventive effects
Authors: G. Varricchi, R. Poto, M. Lommatzsch, G. Brusselle, F. Braido, J. C. Virchow, G. W. Canonica
Journal: Allergy (2024)

Although airway remodeling in severe and/or fatal asthma is still considered irreversible, its individual components as a cause of clinical symptoms and/or lung function changes remain largely unknown. While inhaled glucocorticoids have not consistently been shown to affect airway remodeling, biologics targeting specific pathways of airway inflammation have been shown to improve lung function, mucus plugging, and airway structural changes that can exceed those seen with glucocorticoids. This superiority of biologic treatment, which cannot be solely explained by insufficient doses or limited durations of glucocorticoid therapies, needs to be further explored. For this field of research, we propose a novel classification of the potential effects of biologics on airway remodeling into three temporal effects: early effects (days to weeks, primarily modulating inflammatory processes), late effects (months to years, predominantly affecting structural changes), and potential preventive effects (outcomes of early treatment with biologics). For the identification of potential preventive effects of biologics, we call for studies exploring the impact of early biological treatment on airway remodeling in patients with moderate-to-severe asthma, which should be accompanied by a long-term evaluation of clinical parameters, biomarkers, treatment burden, and socioeconomic implications.
Corrigendum to “Impact of Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography on Prostate Cancer Salvage Radiotherapy Management: Results from a Prospective Multicenter Randomized Phase 3 Trial (PSMA-SRT NCT03582774)” [Eur Urol. 86(1) (2024) 52–60]
Authors: Wesley R Armstrong, Amar U Kishan, Kiara M Booker, Tristan R Grogan, David Elashoff, Ethan C Lam, Kevyn J Clark, Michael L Steinberg, Wolfgang P Fendler, Thomas A Hope, Nicholas G Nickols, Johannes Czernin, Jeremie Calais
Journal: European Urology (2024)
Gendered environmental pathways to sports injury: insights from retired athletes in the UK high-performance context
Authors: Stephanie E Coen, Victoria Downie, Lucy Follett, Steve McCaig, Joanne L Parsons
Journal: British Journal of Sports Medicine (2024)

Objective Women remain at increased risk for some sports injuries, such as anterior cruciate ligament rupture and concussion. This study applied a gendered environmental approach to identify modifiable features of women’s sport environments that may contribute to the gendered patterning of sports injuries. Our objectives were to identify features of gendered environments that mattered in athletes’ lived experiences and to trace pathways connecting these features to injury. Methods We employed a creative methodology combining semi-structured interviews with artefact-elicited storytelling and poetic transcription to actively centre women athletes’ voices and communicate their experiences in formats intended to stimulate reflection among sport system stakeholders. Results Drawing on insights from 20 recently retired women athletes across 11 UK high-performance sports, our reflexive thematic analysis identified five gendered environmental challenges shaping women’s injury experiences, risk and outcomes: (1) stereotypes trivialise injury, (2) physiology is all or nothing, (3) the ‘ideal’ female athlete, (4) in/visible inequities and (5) uneven power dynamics. Within these gendered environmental challenges, we identified mechanisms through which challenges manifest in the everyday experiences of athletes, highlighting these as potential points to disrupt the gendered environments-to-injury pathway. Conclusion Our findings provide an evidence-based framework for categorising and addressing gendered environmental challenges in women’s sport. Interventions to reconfigure the gendered status quo within sport should be embedded as part of injury prevention strategies.
Influence of study characteristics on harm estimates from randomised controlled trials in patients with inflammatory arthritis receiving biological or synthetic antirheumatic drugs: a meta-epidemiological study
Authors: Johannes Iuel Berg, Sabrina Mai Nielsen, Esben Malm, John P A Ioannidis, Daniel E Furst, Josef S Smolen, Peter C Taylor, Lars Erik Kristensen, Simon Tarp, Torkell Ellingsen, Robin Christensen
Journal: Annals of the Rheumatic Diseases (2024)

To examine the association between study characteristics and the harms reported in randomised controlled trials (RCTs) on biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in patients with inflammatory arthritis (IA).
Shared lung and joint T cell repertoire in early rheumatoid arthritis driven by cigarette smoking
Authors: Koen Venken, Matthias Jarlborg, Frederik Stevenaert, Thomas L A Malfait, Carolien Vlieghe, Yann Abraham, Teddy Manuello, Tine Decruy, Stijn Vanhee, Hans Wils, Pieter J Peeters, Philippe Carron, Filip Van den Bosch, Viggo Van Tendeloo, Bart N Lambrecht, Ruth Wittoek, Peggy Jacques, Dirk Elewaut
Journal: Annals of the Rheumatic Diseases (2024)

Smoking has been associated with an increased risk of developing rheumatoid arthritis (RA) in individuals carrying shared epitope (SE) HLA-DRB1 alleles. Yet, little is known about the regional and systemic T cell dynamics of smoking and a potential link to T cell infiltration in inflamed synovia. In this study, we, therefore, sought to study T cell features in lung and inflamed joints in smoking versus non-smoking patients.
Impact of Pseudomonas aeruginosa carriage on ICU-acquired pneumonia: a European multicentre prospective cohort study
Authors: Claudia Recanatini, Cornelis H van Werkhoven, Thomas E van der Schalk, Fleur Paling, Derek Hazard, Leen Timbermont, Gabriel Torrens, Antonio DiGiandomenico, Mark T Esser, Martin Wolkewitz, Frangiscos Sifakis, Herman Goossens, Marc Bonten, Antonio Oliver, Surbhi Malhotra-Kumar, Jan Kluytmans
Journal: Clinical Microbiology and Infection (2024)
Accuracy and efficiency of drilling trajectories with augmented reality versus conventional navigation randomized crossover trial
Authors: Yao Li, Sergey Drobinsky, Paulina Becker, Kunpeng Xie, Myriam Lipprandt, Christian Andreas Mueller, Jan Egger, Frank Hölzle, Rainer Röhrig, Klaus Radermacher, Matías de la Fuente, Behrus Puladi
Journal: npj Digital Medicine (2024)

Conventional navigation systems (CNS) in surgery require strong spatial cognitive abilities and hand-eye coordination. Augmented Reality Navigation Systems (ARNS) provide 3D guidance and may overcome these challenges, but their accuracy and efficiency compared to CNS have not been systematically evaluated. In this randomized crossover study with 36 participants from different professional backgrounds (surgeons, students, engineers), drilling accuracy, time and perceived workload were evaluated using ARNS and CNS. For the first time, this study provides compelling evidence that ARNS and CNS have comparable accuracy in translational error. Differences in angle and depth error with ARNS were likely due to limited stereoscopic vision, hardware limitations, and design. Despite this, ARNS was preferred by most participants, including surgeons with prior navigation experience, and demonstrated a significantly better overall user experience. Depending on accuracy requirements, ARNS could serve as a viable alternative to CNS for guided drilling, with potential for future optimization.
Genomic profiling of circulating tumor DNA for childhood cancers
Authors: Shaohua Lei, Sujuan Jia, Sunitha Takalkar, Ti-Cheng Chang, Xiaotu Ma, Karol Szlachta, Ke Xu, Zhongshan Cheng, Yawei Hui, Selene C. Koo, Paul E. Mead, Qingsong Gao, Priyadarshini Kumar, Colin P. Bailey, Jobin Sunny, Alberto S. Pappo, Sara M. Federico, Giles W. Robinson, Amar Gajjar, Jeffrey E. Rubnitz, Sima Jeha, Ching-Hon Pui, Hiroto Inaba, Gang Wu, Jeffery M. Klco, Ruth G. Tatevossian, Charles G. Mullighan
Journal: Leukemia (2024)
A diverse hidradenitis suppurativa cohort: a retrospective cross-sectional study of 13,130 patients from a large US healthcare system database from 1995-2022
Authors: Kelly Z. Young, Ian Loveless, Wan-Ting K. Su, Jesse Veenstra, Congcong Yin, Peter Dimitrion, Rachel Krevh, Li Zhou, Ruicong She, Mingming Pan, Albert M. Levin, Albert Young, Eglal Samir, Andrea Dai, James Ge, Richard H. Huggins, Cristina de Guzman Strong, Henry W. Lim, David M. Ozog, Iltefat Hamzavi, Indra Adrianto, Qing-Sheng Mi
Journal: Journal of the American Academy of Dermatology (2024)
Retrospective analysis of virtual gene panel analysis for genodermatoses reveals a high diagnostic yield in clinical practice
Authors: Aude Beyens, Jozefien Weytens, Lore Pottie, Sofie De Meulemeester, Karolien Aelbrecht, Silke De Feyter, Sofie De Schepper, Eline Van Holm, Sofie Symoens, Bert Callewaert
Journal: Journal of the American Academy of Dermatology (2024)
Combined Topical 5-Fluorouracil and Calcipotriene Effectively Treats Superficial Keratinocyte Carcinomas: A retrospective cohort study from two academic centers
Authors: Nicole Loranger, Fatima N. Mirza, Truelian Lee, Ethan Lowder, Emily Karn, Tiffany Libby, Emily Ruiz, Lauren Guggina
Journal: Journal of the American Academy of Dermatology (2024)
Recommendations and quality of multimorbidity guidelines: a systematic review
Authors: Zijun Wang, Di Zhu, Huayu Zhang, Ling Wang, Hongfeng He, Zhewei Li, Bingyi Wang, Jie Zhang, Xiaoqing Li, Hanna Tuinhof, Barbara C van Munster, Yaolong Chen, Janne Estill
Journal: Ageing Research Reviews (2024)