tbuckley/cabot-search huggingface dataset:
Abstract P2098: The Interaction of Vascular Risk Factors in Midlife and Late-life on Incident Dementia: The Atherosclerosis Risk in Communities Neurocognitive Study
Authors: Jason Smith, James Pike, Rebecca Gottesman, Pamela Lutsey, Priya Palta, B Gwen Windham, Elizabeth Selvin, David Knopman, Josef Coresh, A Sharrett, Alden Gross, Jennifer Deal
Journal: Circulation (2025)

Introduction: Vascular risk factors of hypertension, diabetes, and smoking in midlife (45-64 years) and possibly early late-life (65-74 years) are associated with increased risk of dementia. Current estimates of population attributable risk for dementia assume vascular factors are independent and do not interact to increase risk of dementia, which may underestimate the combined impact of vascular risk reduction on dementia incidence. In this study, we evaluated the joint association and interaction of vascular risk factors on risk of dementia. Methods: We performed a prospective cohort analysis using the Atherosclerosis Risk in Communities Neurocognitive Study using up to 33 years of follow-up (1987-2020). We used age as baseline (45-54 years, n=7,731; 55-64 years, n=12,273; and 65-74 years, n=6,660). We defined hypertension as systolic blood pressure ≥130 mm Hg, diastolic blood pressure ≥80 mm Hg, or anti-hypertension medication use. We defined diabetes as fasting glucose level ≥126 mg/dL, non-fasting glucose ≥200 mg/dL, self-reported physician diagnosis, or use of any diabetes medication. Current smoking was self-reported. We investigated additive and multiplicative interactions for combinations of vascular risk factors on incident (adjudicated) dementia by age 80 using joint effect variables in Cox regression models stratified by age of risk factor measurement (45-54 years, 55-64 years, or 65-74 years). For interaction analyses, parameter values &gt;1 indicate positive interaction (synergy) and values &lt;1 indicate negative interaction (antagonism). Results: In participants with risk factors measured in these baseline age strata, there were 801 (10%), 995 (8%), and 422 (6%) cases of incident dementia by age 80, respectively. Hypertension and diabetes exhibited positive interactions on the additive and multiplicative scales in midlife (Figure 1). Diabetes and smoking in midlife had positive additive interaction (value &gt;1, Figure 2). All vascular risk factor combinations in late-life had negative interactions on the multiplicative scale (values &lt;1, Figures 1-3). Conclusions: Hypertension with diabetes and diabetes with smoking, all measured in midlife, interact to increase risk of dementia by age 80. The overall impact of reducing midlife vascular risk factors on incident dementia could be sizeable. These findings highlight the importance of multifactor interventions addressing combinations of vascular risk factors for dementia prevention strategies.
Abstract P3067: State Adoption of Paid Sick Leave and Cardiovascular Disease Mortality Among Adults Aged 15-64 in the United States, 2008 to 2019
Authors: Samuel Swift, Lexi O'Donnell, Brady Horn, Katrina Kezios, Tali Elfassy, Julie Reagan, Adina Zeki Al Hazzouri, Tracie Collins
Journal: Circulation (2025)

Cardiovascular Disease (CVD) is the leading cause of death in the United States and may be prevented through improved working conditions. The United States does not guarantee paid sick leave (PSL) at the federal level. Our objective was to examine the relationship between state-level PSL policies and CVD mortality. We used quasi-experimental event study methods proposed by Sun and Abraham to examine the relationship between implementing a mandatory PSL policy for all employees at the state-level and county-level CVD mortality among working-age adults aged 15 to 64 over time from 2008 to 2019. We examined the annual CVD mortality rates (2008-2019) in 1054 counties from all 50 states and Washington D.C., accounting for approximately 88% of the United States population. We found that in the Northeastern region of the United States, there were drops in the CVD mortality rate for persons ages 15-64 for all years after PSL was adopted, ranging from 6.0 fewer deaths per 100,000 persons (β=-6.0, 95% CI = -10.1, -1.9) seven years post-treatment to 2.9 fewer deaths three years post-treatment (β=-2.9, 95% CI= -4.9, -0.9). We found no effect of PSL in the Western United States, and mixed effects in a nationwide analysis. Finally, the strong presence of pretreatment effects in the Western United States makes the results for that region uninterpretable. Our results support the use of state-level PSL policies to reduce county-level CVD mortality rates in the Northeastern United States.
Abstract 023: Comparison of Office and Ambulatory Blood Pressure in Middle-Aged Adults: Findings from the DASH and DASH-Sodium Study
Authors: Md Marufuzzaman Khan, Mingyu Zhang, Ruth-Alma Turkson-Ocran, Long Ngo, Lawrence Appel, Edgar Miller, Stephen Juraschek
Journal: Circulation (2025)

Background: Ambulatory blood pressure (ABP) captures BP throughout the day during a range of activities, body positions, and environments, while office blood pressure (OBP) is performed in a rested, seated position in clinic. Since ABP on average is lower than OBP, current guidelines recommend setting lower risk thresholds for ABP compared to OBP. Objective: To determine equivalent values of OBP and awake ABP in middle-aged adults with respect to subclinical cardiovascular disease (CVD). Methods: DASH and DASH-Sodium trials were feeding studies that enrolled adults age 22 and older with a systolic BP of 120 to 159 mmHg and diastolic BP of 80 to 95 mmHg without treated hypertension, diabetes, or recent CVD. In both trials, ABP and OBP were concurrently measured at two (DASH) or three (DASH-Sodium) visits. ABP was performed using a Spacelabs device for 24 hours. OBP was performed with a random-zero sphygmomanometer three times per visit over 4-5 visits, following a standardized research protocol. We measured three cardiac biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity cardiac troponin I (hs-cTnI), and high sensitivity C-reactive protein (hs-CRP) in serum collected concurrent with ABP. We investigated equivalent values of OBP and awake ABP by using the equipercentile equating method. We calculated the risk of elevated biomarkers for OBP and awake ABP using logistic models with generalized estimating equations, and identified BP values that corresponded to the same risk of elevated biomarkers. Results: There were 587 participants (mean age 47.8±10 years, 51.9% female, and 52.9% Black) with 1,238 visits ( Table 1 ). OBP values consistently corresponded with higher values of awake ABP ( Table 2 ). Using the equipercentile equating method, OBP of 130/80 mmHg and 140/90 mmHg corresponded to awake ABP of 136/83 mmHg and 145/95 mmHg, respectively. Based on cardiac biomarkers, an OBP of 130/80 mmHg had the same risk of elevated NT-proBNP, hs-cTnI, and hs-CRP as an awake ABP of 135/83, 135/84, and 138/80 mmHg, respectively. Conclusion: Contrary to current guidelines, ABP thresholds for risk among relatively healthy, middle-aged adults, were higher than OBP. These findings challenge guidelines promoting universal equivalency values for interpreting out-of-office BP measures such as ABP, and imply that risk thresholds may vary by context, population, and the quality of the office measurement.
Corrigendum to “Dual-responsive nanoparticles for enhanced drug delivery in breast cancer chemotherapy” [Volume 377, 10 January 2025, Pages 146–161]
Authors: Yuxin Ren, Peishan Li, Ying Xie, Jiarui Xu, Qian Luo, Ming Chen, Rui Liu, Hexuan Feng, Yuling Chen, Yixuan Liu, Chunjie Bao, Jialun Duan, Jianwei Li, Wanliang Lu
Journal: Journal of Controlled Release (2025)
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus
Authors: Minoru Matsumoto, Masaki Yoshida, Takeshi Oya, Koichi Tsuneyama, Mitsuru Matsumoto, Hideyuki Yoshida
Journal: The Journal of Experimental Medicine (2025)

The transcriptional targets of Aire and the mechanisms controlling their expression in medullary thymic epithelial cells (mTECs) need to be clarified to understand Aire’s tolerogenic function. By using a multi-omics single-cell approach coupled with deep scRNA-seq, we examined how Aire controls the transcription of a wide variety of genes in a small fraction of Aire-expressing cells. We found that chromatin repression by PRC2 is an important step for Aire to achieve stochastic gene expression. Aire unleashed the silenced chromatin configuration caused by PRC2, thereby increasing the expression of its functional targets. Besides this preconditioning for Aire’s gene induction, we demonstrated that PRC2 also controls the composition of mTECs that mimic the developmental trait of peripheral tissues, i.e., mimetic cells. Of note, this action of PRC2 was independent of Aire and it was more apparent than Aire. Thus, our study uncovered the essential role of polycomb complex for Aire-mediated promiscuous gene expression and the development of mimetic cells.
Factors Associated with Disease Progression after Discontinuation of Immune Checkpoint Inhibitors for Immune-Related Toxicity in Patients with Advanced Non–Small Cell Lung Cancer
Authors: Federica Pecci, Rohit Thummalapalli, Stephanie L. Alden, Biagio Ricciuti, Joao V. Alessi, Arielle Elkrief, Hira Rizvi, Xinan Wang, Mark Jeng, Jacklynn V. Egger, Victor R. Vaz, Adriana Barrichello, Giuseppe Lamberti, Alessandro Di Federico, Valentina Santo, Guilherme Rossato de Almeida, Malini Gandhi, Phoebe Clark, Mizuki Nishino, Bruce E. Johnson, Matthew Hellmann, Adam J. Schoenfeld, Mark M. Awad
Journal: Clinical Cancer Research (2025)

Abstract Purpose: Among patients with advanced non–small cell lung cancer (NSCLC) who discontinue immune checkpoint inhibitors (ICI) because of immune-related adverse events (irAE), post-discontinuation clinical outcomes and factors associated with disease progression after discontinuation are largely unknown. Experimental Design: Clinicopathologic data were abstracted from patients with advanced NSCLC who received ICI and discontinued treatment because of irAE. Factors associated with post-discontinuation progression-free survival (PFS) and post-discontinuation overall survival (OS) were evaluated. Results: Of 2,794 patients, 10% (N = 271) discontinued ICI because of irAE, and the median duration of ICI treatment before discontinuation for irAE was 5.9 months (range, 0.03–73.5). A longer treatment duration before discontinuation for irAE was associated with improved post-discontinuation outcomes: for patients on ICI for &amp;lt;3 months (N = 89), 3 to 6 months (N = 49), and &amp;gt;6 months (N = 133) before discontinuing for irAE, the median post-discontinuation PFS was 6.2, 13.9, and 25.8 months (P &amp;lt; 0.001), respectively, and the median post-discontinuation OS was 21.7, 42.7, and 86.9 months (P &amp;lt; 0.001), respectively. At multivariable analyses, predictors of longer post-discontinuation PFS were PD-L1 ≥ 50%, complete response/partial response (CR/PR) to treatment, and treatment duration before discontinuation between 3 to 6 months and &amp;gt;6 months; predictors of longer post-discontinuation OS were nonsquamous histology, CR/PR, and treatment duration before discontinuation &amp;gt;6 months. The use of immunosuppressive agents for toxicity management did not affect post-discontinuation outcomes. Conclusions: A longer treatment duration before discontinuation, a best objective response of CR/PR, PD-L1 ≥50%, and nonsquamous histology may help clinicians identify patients who may experience long-term disease control after discontinuation of ICI for irAE.
Multifunctional piezoelectric hydrogels under ultrasound stimulation boost chondrogenesis by recruiting autologous stem cells and activating the Ca2+/CaM/CaN signaling pathway
Authors: Yu-Bao Liu, Xu Liu, Xiao-Fei Li, Liang Qiao, Hao-Liang Wang, Yue-Fu Dong, Feng Zhang, Yang Liu, Hao-Yang Liu, Ming-Liang Ji, Lan Li, Qing Jiang, Jun Lu
Journal: Bioactive Materials (2025)
ORCHESTRA Delphi consensus: diagnostic and therapeutic management of Post-COVID-19 condition in vulnerable populations
Authors: Elisa Gentilotti, Lorenzo Maria Canziani, Maria Giulia Caponcello, Anna Maria Azzini, Alessia Savoldi, Pasquale De Nardo, Zaira R Palacios-Baena, Beatrice Tazza, Natascia Caroccia, Giulia Marchetti, Andrea Antinori, Maddalena Giannella, Jesús Rodríguez-Baño, Evelina Tacconelli
Journal: Clinical Microbiology and Infection (2025)
Machine learning based radiomic models outperform clinical biomarkers in predicting outcomes after immunotherapy for hepatocellular carcinoma
Authors: Mathew Vithayathil, Deniz Koku, Claudia Campani, Jean-Charles Nault, Olivier Sutter, Nathalie Ganne Carrié, Eric O Aboagye, Rohini Sharma
Journal: Journal of Hepatology (2025)
Albumin infusion in Hepatorenal Syndrome-Acute Kidney Injury: new evidence challenges recent consensus.
Authors: Paolo Angeli, Christian Labenz, Salvatore Piano, Adrià Juanola, Aleksander Krag, Paolo Caraceni, Jonel Trebicka, Rakhi Maiwall, Virendra Singh, Elisa Pose, Carmine Gambino, Sebastian Marciano, Peter R Galle, Shiv K Sarin, Pere Ginès, Patrick S Kamath
Journal: Journal of Hepatology (2025)
Outbreak of Cyclosporiasis Among Patrons of a Mexican-Style Restaurant — Limestone County, Alabama, May–June 2023
Authors: Justine Goetzman, Adyneshia Carter, Ana Oliveira, L. Amanda Ingram
Journal: MMWR Morbidity and Mortality Weekly Report (2025)

In early June 2023, the Alabama Department of Public Health identified five laboratory-confirmed cyclosporiasis case reports with a common patient exposure of eating at one Mexican-style restaurant. Common signs of cyclosporiasis include diarrhea, abdominal cramps, nausea, and loss of appetite. Although most illnesses are self-limited, antibiotic treatment can prevent relapsing illness. Onset of illness for the initial five patients occurred during May 26-30. An outbreak investigation was initiated on June 7. Routine case investigations and case finding through the restaurant's food delivery service contact list identified 42 additional cases. Multivariable analysis of case-control study data revealed that illness was associated with consumption of cilantro (odds ratio = 40.9; 95% CI = 6.4-808.6). The cilantro was traced back to a Texas firm with no identified food manufacturing license that sourced the product from Mexico. The outbreak and its investigation demonstrate the ongoing need for regulatory controls of produce suppliers, documentation and review of business licenses, and increasing public awareness of food safety and outbreaks. Distribution of potentially contaminated products via improper supply chain channels remains a public health challenge. Avoiding infection in the United States involves preventing contaminated produce from reaching local retailers and consumers.
NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis
Authors: Rui Zhan, Xia Meng, Dongping Tian, Jie Xu, Hongtu Cui, Jialei Yang, Yangkai Xu, Mingming Shi, Jing Xue, Weiwei Yu, Gaofei Hu, Ke Li, Xiaoxiao Ge, Qi Zhang, Mingming Zhao, Jianyong Du, Xin Guo, Wenli Xu, Yang Gao, Changyu Yao, Fan Chen, Yue Chen, Wenxin Shan, Yujie Zhu, Liang Ji, Bing Pan, Yan Yu, Wenguang Li, Xuyang Zhao, Qihua He, Xiaohui Liu, Yue Huang, Shengyou Liao, Bin Zhou, Dehua Chui, Y. Eugene Chen, Zheng Sun, Erdan Dong, Yongjun Wang, Lemin Zheng
Journal: Neuron (2025)
Hydrophobic ion pairing enables co-loading of water-soluble drugs in polymeric micelles
Authors: Armin Azadkhah Shalmani, Rasika Daware, Asmaa Said Elshafei, Federica De Lorenzi, Diana Moeckel, Eva M Buhl, Barbara Mara Klinkhammer, Peter Boor, Srinivas Banala, Alina Adams, Fabian Kiessling, Gert Storm, Josbert M Metselaar, Alexandros Marios Sofias, Yang Shi, Twan Lammers, Quim Peña, Tarun Ojha
Journal: Journal of Controlled Release (2025)

Polymeric micelles are widely used for the delivery of hydrophobic drugs. However, several highly potent and ubiquitously used anticancer drugs are water-soluble, complicating their (co-) formulation in polymeric micelles without having to chemically modify them. We here explore hydrophobic ion pairing to enable the co-delivery of the water-soluble anthracycline chemotherapy drug doxorubicin and the angiotensin II receptor antagonist telmisartan (a clinically used antihypertensive drug that has shown promising (pre-) clinical outcomes in combination with anthracyclines). We show that hydrophobic ion pairing of doxorubicin and telmisartan promotes the co-encapsulation of both drugs in π electron-stabilized [PEG-b-p(HPMAm-Bz)]-based polymeric micelles. The cytotoxic activity of doxorubicin is retained, and the dual drug-loaded micelles display enhanced antitumor activity in vivo as compared to the combination of the free drugs, while also exhibiting good tolerability. Taken together, this work provides proof-of-concept for hydrophobic ion pairing as a promising formulation strategy to promote multidrug nanomedicine and drug combination therapy.
Characteristics and pharmacological responsiveness in hiPSC models of inherited cardiomyopathy
Authors: Merel Gerritse, Willem B van Ham, Chris Denning, Toon A B van Veen, Renee G C Maas
Journal: Pharmacology & Therapeutics (2025)

Inherited cardiomyopathies are a major cause of heart failure in all age groups, often with an onset in adolescence or early adult life. More than a thousand variants in approximately one hundred genes are associated with cardiomyopathies. Interestingly, many genetic cardiomyopathies display overlapping phenotypical defects in patients, despite the diversity of the initial pathogenic variants. Understanding how the underlying pathophysiology of genetic cardiomyopathies leads to these phenotypes, will improve insights into a patient's disease course and creates the opportunity for conceiving treatment strategies. Moreover, therapeutic strategies can be used to treat multiple cardiomyopathies based on shared phenotypes. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer reliable, high-throughput models for studying molecular and cellular characteristics of hereditary cardiomyopathies. hiPSC-CMs are produced relatively easily, either by directly originating them from patients, or by introducing patient-specific genetic variants in healthy lines. This review evaluates 90 studies on 24 cardiomyopathy-associated genes and systematically summarises the morphological and functional phenotypes observed in hiPSC-CMs. Additionally, treatment strategies applied in cardiomyopathic hiPSC-CMs are compiled and scored for effectiveness. Multiple overlapping phenotypic defects were identified in cardiomyocytes with different variants, whereas certain characteristics were only associated with specific genetic variants. Based on these findings, common mechanisms, therapeutic prospects, and considerations for future research are discussed with the aim to improve clinical translation from hiPSC-CMs to patients.
Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease (Adv. Healthcare Mater. 10/2025)
Authors: Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig
Journal: Advanced Healthcare Materials (2025)
3D‐Bioprinting for Precision Microtissue Engineering: Advances, Applications, and Prospects (Adv. Healthcare Mater. 10/2025)
Authors: Jinrun Liu, Qi Wang, Yinpeng Le, Min Hu, Chen Li, Ni An, Qingru Song, Wenzhen Yin, Wenrui Ma, Mingyue Pan, Yutian Feng, Yunfang Wang, Lu Han, Juan Liu
Journal: Advanced Healthcare Materials (2025)
Natural Extracellular Matrix Scaffold‐Based Hydrogel Corneal Patch with Temperature and Light‐Responsiveness for Penetrating Keratoplasty and Sutureless Stromal Defect Repair (Adv. Healthcare Mater. 10/2025)
Authors: Long Zhao, Zhen Shi, Jingting Wang, Shengqian Dou, Xiuli Sun, Shang Yang, Hongwei Wang, Qingjun Zhou, Ting Wang, Weiyun Shi
Journal: Advanced Healthcare Materials (2025)
Biocompatibility of Water‐Dispersible Pristine Graphene and Graphene Oxide Using a Close‐to‐Human Animal Model: A Pilot Study on Swine (Adv. Healthcare Mater. 10/2025)
Authors: Paola Nicolussi, Giovannantonio Pilo, Maria Giovanna Cancedda, Guotao Peng, Ngoc Do Quyen Chau, Alejandro De la Cadena, Renzo Vanna, Yarjan Abdul Samad, Tanweer Ahmed, Jeremia Marcellino, Giuseppe Tedde, Linda Giro, Acelya Ylmazer, Federica Loi, Gavina Carta, Loredana Secchi, Silvia Dei Giudici, Simona Macciocu, Dario Polli, Yuta Nishina, Ciriaco Ligios, Giulio Cerullo, Andrea Ferrari, Alberto Bianco, Bengt Fadeel, Giulia Franzoni, Lucia Gemma Delogu
Journal: Advanced Healthcare Materials (2025)
The Utility of Collagen VII Topical Gene Therapy in Treatment of Surgical Defect after Excision of Recessive Dystrophic Epidermolysis Bullosa associated Squamous Cell Carcinoma
Authors: Molly Wallace, Rishob Dasgupta, Karen Cravero, Henry Yang, Andrew P South, Neda Nikbakht
Journal: British Journal of Dermatology (2025)

This case report describes the use of beremagene geperpavec (B-VEC), the first FDA-approved topical gene therapy for recessive dystrophic epidermolysis bullosa (RDEB), in the treatment of a large surgical defect following excision of squamous cell carcinoma (SCC) in a 55-year-old RDEB patient. After a wide local excision, the wound was treated with B-VEC, resulting in complete healing within 7 weeks, with no complications or recurrence at 10-month follow-up. This novel approach highlights the potential of B-VEC to improve surgical outcomes and wound healing in RDEB patients.
Current Trends and Challenges in the Clinical Use of Cardiovascular Magnetic Resonance. A Survey from the Italian Society of Cardiology
Authors: Lorenzo Monti, Fabrizio Ricci, Andrea Baggiano, Andrea Barison, Nazario Carrabba, Stefano Figliozzi, Patrizia Pedrotti, Camilla Torlasco, Erika Tempo, Alessandro Giaj Levra, Stefania Paolillo, Gianfranco Sinagra, Pasquale Perrone Filardi, Ciro Indolfi, Santo Dellegrottaglie
Journal:  (2025)

Abstract Aims Challenges related to the use of cardiovascular magnetic resonance (CMR) remain a key issue to secure its full clinical impact. This survey aimed to assess the awareness of CMR clinical utility and to collect data on its local usage levels, operational barriers, and report efficacy, with the goal of identifying key obstacles to its effective implementation across Italy. Methods and results The CMR Working Group of the Italian Society of Cardiology promoted an online survey targeting Italian physicians involved in direct care of patients with cardiovascular disease. The questionnaire was completed by 709 physicians, mostly working in public or university hospitals (75%); 27% were medical residents. Cardiomyopathies and myocarditis were identified as the most established clinical indications for CMR. 79% of respondents perceived underutilisation of CMR in their local settings, with waiting times exceeding 3 months in 42% of cases. Public hospitals were reported as the primary providers of CMR services (41%), with the majority of CMR reports signed exclusively by radiologists. Obstacles in obtaining clinically useful and effective CMR exams were frequent, with 69% of respondents often encountering issues. Need for an expert second opinion was reported by 27% of participants either often or always. Stress CMR was reported of limited access or unavailable by 79% of respondents. Conclusion CMR is highly regarded for its clinical utility but underutilized due to operational barriers, mainly long waiting times and lack of specific competence. Perceived inadequacy in report quality is common and contributes to a consistent rate of second-opinion requests.