tbuckley/cabot-search huggingface dataset:
Abstract P120: Effect of Age on Hemodynamics, Heart Rate Variability, and Outcome in a Murine Model of Sepsis
Authors: Steven Hollenberg, Sergio Zanotti, Jad Skaf, Hady Lichaa, Anupam Gupta, Josh Weinstock, Joseph E Parrillo
Journal: Circulation (2008)

Background: The incidence and mortality of sepsis increase with aging, but animal models often use young animals whose biological ages do not reflect patient populations. We compared old and young mice in a murine model of resuscitated sepsis. Methods: C57Bl/6 mice (Young 2–3 months, n=32; Old 15–20 months, n=24) were made septic by cecal ligation and puncture (CLP) and resuscitated with fluids and antibiotics q 6 hr; controls underwent sham ligation. Serial echocardiography using a 30MHz probe was performed under light isoflurane anesthesia for measurement of stroke volume (SV), fractional shortening (FS), and cardiac output (CO). Blood pressure was measured using implantable radiotelemeters. From the waveforms, heart rate volatility (% of 5 minute intervals with standard deviation &lt; the lowest 5% of baseline), an index of heart rate variability less susceptible to artifact than other measures, was derived for the entire experiment. Results: After CLP, heart rate and blood pressure did not differ significantly between old and young mice. SV decreased early in both groups (old 54.4 to 25.6 μL, young 57.2 to 24.0 p&lt;0.01 vs baseline), as did CO. With resuscitation, SV and CO improved in both groups (old 48.0 μL and 24.5 ml/min, young 44.0 μL and 20.7 ml/min). Old animals were larger than young animals, but normalized values (% change from baseline) for SV, CO, and LVEDV were similar after CLP. Old septic mice had more periods of low heart rate volatility than young septic mice or old controls (62% vs 37% vs 3% of the experimental period). Mortality tended to be higher in old than young mice (46% vs 22% at 72 hr, p=0.09, 54% vs 22% at 144 hr, p=0.06). Conclusion: In a clinically relevant model of murine sepsis, age did not have a significant impact on hemodynamics, but decreased heart rate variability was more prominent in aged mice, and age was associated with increased mortality. This suggests the potential for nonlinear hemodynamic parameters to provide insights into both the pathogenesis of disease and the effects of aging.
Intestinal Volvulus in Idiopathic Steatorrhea
Authors: H A WARNER, D G KINNEAR, D G CAMERON
Journal: JAMA (1963)

Volvulus of the intestine has recently been observed in three patients with idiopathic steatorrhea in relapse. Two patients gave a history of intermittent abdominal pain, distension and obstipation. Radiographic studies during these attacks revealed obstruction at the level of the sigmoid colon. Reduction under proctoscopic control was achieved in one instance, spontaneous resolution occurring in the other. The third patient presented as a surgical emergency and underwent operative reduction of a small intestinal volvulus. Persistence of diarrhea and weight loss postoperatively led to further investigation and a diagnosis of idiopathic steatorrhea. In all cases, treatment resulted in clinical remission with a coincident disappearance of obstructive intestinal symptoms. The pathogenesis of volvulus in sprue is poorly understood. Atonicity and dilatation of the bowel and stretching of the mesentery likely represent important factors. The symptoms of recurrent abdominal pain and distension in idiopathic steatorrhea necessitate an increased awareness of intestinal volvulus as a complication of this disease.
CONSTITUTIONAL HEPATIC DYSFUNCTION
Authors: J J CHOSEY, F M BEMAN
Journal: Annals of Internal Medicine (1958)

Case Reports1 January 1958CONSTITUTIONAL HEPATIC DYSFUNCTIONJULIUS J. CHOSEY, M.D., FLOYD M. BEMAN, M.D.JULIUS J. CHOSEY, M.D.Search for more papers by this author, FLOYD M. BEMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-1-202 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONJaundice is ordinarily considered to be a sign of altered bilirubin metabolism. The significance of this symptom is evident when one considers the elaborate studies carried out in an attempt to clarify the mechanism in any given case. Occasionally the opportunity arises to study a patient with jaundice who apparently does not fit into any of the standard categories, and in whom the presence of an elevated bilirubin is compatible with good health.Constitutional hepatic dysfunction was probably first described by Gilbert and his associates in 1902. Since that time, several excellent reviews of this subject have been presented,...Bibliography1. Schiff L: Serum bilirubin in health and disease, Arch. Int. Med. 40: 800, 1927. CrossrefGoogle Scholar2. RozendaalComfortSnell HMMWAM: Slight and latent jaundice; the significance of elevated concentration of bilirubin giving an indirect van den Bergh reaction, J. A. M. A. 104: 374 (Feb. 2) 1935. CrossrefGoogle Scholar3. Comfort MW: Constitutional hepatic dysfunction, Proc. Staff Meet., Mayo Clin. 10: 57, 1935. Google Scholar4. MalloyLowenstein HTL: Hereditary jaundice in the rat, Canad. M. A. J. 42: 122-125 (Feb.) 1940. MedlineGoogle Scholar5. DameshekSinger WK: Familial non hemolytic jaundice; constitutional hepatic dysfunction with indirect van den Bergh reaction, Arch. Int. Med. 67: 259 (Feb.) 1941. CrossrefGoogle Scholar6. CurryGreenwaltTat JJTJRJ: Familial non hemolytic jaundice. Report of a case with liver biopsy, New England J. Med. 226: 909, 1942. CrossrefGoogle Scholar7. ComfortHoyne MWRM: Constitutional hepatic dysfunction: clinical study of thirty-five cases, Gastroenterology 3: 155-163 (Sept.) 1944. Google Scholar8. Comfort MW: Constitutional hepatic dysfunction, M. Clin. North America 29: 982 (July 29) 1945. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, Ohio*Received for publication August 10, 1956.From the Division of Gastroenterology, Department of Medicine, Ohio State University, Columbus, Ohio.†This study was supported in part by the Comley Fund for Medical Research.Requests for reprints should be addressed to Floyd M. Beman, M.D., Division of Gastroenterology, Department of Medicine, The Ohio State University, Columbus 10, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1958Volume 48, Issue 1Page: 202-205KeywordsBilirubinResearch funding ePublished: 1 December 2008 Issue Published: 1 January 1958 PDF downloadLoading ...
BST2 over-expression is associated with the formation of bone metastasis in breast cancer
Authors: Ziqiang Yuan, Anu Gaba, T. Sotsky Kent, A. Miller, Thomas Weber
Journal: Cancer Research (2005)

2920  Introduction: The molecular mechanism of metastatic bone disease in breast cancer remains unknown. Bone marrow stromal cell antigen 2 (BST2) was previously described in melanoma. We recently made the novel observation of BST2 protein expression in human breast cancer cell lines. The purpose of our present study was to investigate the expression of BST2 in primary breast cancer and its association with the development of metastatic breast cancer to bone. Materials and Methods:. cDNA microarray analysis was used to compare BST2 gene expression in a primary human breast cancer cell line (MDA-231) and a metastatic to bone (MTB) human breast cancer cell line (MDA-231 BO). BST2 expression in 8 MTB breast cancer cell lines and 4 primary breast cancer cell lines was also compared using real-time RT-PCR and Western blot assay. We employed tissue array to study BST2 expression in human breast cancer using array slides containing: 30 independent MTB primary breast cancers, 20 non-metastasis forming breast cancers and 4 normal breast tissues. The relationship between BST2 expression, cell growth and apoptosis was studied in a human breast recombinant model system using FACS analysis. Results: Microarray demonstrated over expression of the BST2 gene in the MTB breast cancer cell line MDA-231 BO compared to the primary human breast cancer cell line MDA-231. BST2 was expressed in 80% (7 of 8) of MTB breast cancer cell lines and 0% (0 of 4) non-metastatic breast cancer cell lines as measured by real-time RT-PCR and Western blot assay. Tissue array BST2 expression was observed in over 70% of the cells in each of the 30 MTB bone breast cancer primaries studied. In contrast BST2 expression was observed in 30 to 70% of cells in each of the 20 non-metastatic breast cancer primaries studied (P
Abstract 15880: Live Case Demonstration of Interventional Cardiology Procedures - Is it really safe?
Authors: Shiran Eliyahu, Ariel Roguin, Arthur Kerner, Monther Boulos, Avraham Lorber, Majdi Halabi, Mahmoud Suleiman, Eugenia Nikolsky, Shmuel Rispler, Rafael Beyar
Journal: Circulation (2011)

Background: Professional meetings use live case demonstrations to present cutting edge technology are considered to be a valuable educational resource. There is an ongoing discussion on whether pat...
Early estimates of seasonal influenza vaccine effectiveness in Europe among target groups for vaccination: results from the I-MOVE multicentre case–control study, 2011/12
Authors: E Kissling, M Valenciano, Collective I-MOVE case–control studies team
Journal: Eurosurveillance (2012)

To provide an early estimate of 2011/12 influenza vaccine effectiveness (VE), we conducted a multicentre case-control study based on seven sentinel surveillance networks. We included influenza-like illness cases up to week 7/2012 from the vaccination target groups, swabbed less than eight days after symptom onset. Laboratory-confirmed influenza A(H3) cases were compared to negative controls. Adjusted VE was 43% (95% confidence interval: -0.4 to 67.7), suggesting low to moderate VE against influenza A(H3) in the early 2011/12 season.
Abstract 6223: The Appropriateness of PCI in a Regional Registry is High
Authors: David J Malenka, Elaine M Olmstead, Michael J Hearne, Mirle A Kellett, John F Robb, Peter N Ver Lee, Harold L Dauerman, William J Phillips, Thomas J Ryan, M. Theodore Silver, Winthrop D Piper, Gerald T O’Connor
Journal: Circulation (2008)

Background. Evidence based medicine mandates constant examination of the appropriateness of care. The ACC/AHA/SCAI have published, and updated, PCI guidelines. We assessed the concordance between these guidelines and actual clinical practice in our region. Methods. We evaluated 16,670 consecutive patients undergoing PCI in 2005–2006 at 10 hospitals contributing data to our regional PCI registry. As per the guidelines, we categorized patients into 5 groups (asymptomatic/CCS I-II angina, CCS III angina, UA/NSTEMI, STEMI, patients with prior CABG). Detailed clinical data, including number of diseased vessels and lesion location, myocardium at risk, the probability of angiographic success, and the probability of procedural risk, were then used to categorize procedures within subgroups as follows: Class I (useful and effective); Class IIa (evidence favors usefulness/efficacy); Class IIb (usefulness/efficacy less well established); Class III (not useful or effective). Results. We were able to assign 16,350 patients (98.1%) to a clinical subgroup and within subgroups, to classify 98.9% of procedures. Class I procedures totaled 38.1%; Class IIa 56.0%; Class IIb 0.7%; Class III 4.1%; unclassifiable 1.1%. The class distribution varied by clinical group (Figure ). Of the 664 Class III procedures, 64.6% were asymptomatic/CCS I-II angina, 32.5% UA/NSTEMI, and 2.9% CCS III angina. Conclusion. In this recent, regional experience we found that over 95% of PCI procedures were either Class I or Class II. In northern New England, actual clinical practice closely follows the ACC/AHA/SCAI recommendations for PCI appropriateness. ACC/AHA/SCAI 2005 Guidelines for PCI
Ventricular Ectopy as a Predictor of Heart Failure and Death
Authors: Jonathan W. Dukes, Thomas A. Dewland, Eric Vittinghoff, Mala C. Mandyam, Susan R. Heckbert, David S. Siscovick, Phyllis K. Stein, Bruce M. Psaty, Nona Sotoodehnia, John S. Gottdiener, Gregory M. Marcus
Journal: Journal of the American College of Cardiology (2015)
THE SURGICAL TREATMENT OF PEPTIC ULCER
Authors: Irvin Abell
Journal: Annals of Internal Medicine (1937)

Article1 November 1937THE SURGICAL TREATMENT OF PEPTIC ULCERIRVIN ABELLIRVIN ABELLSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-5-762 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Billroth, following his successful removal of a carcinoma by pylorectomy in 1881, directed his efforts to the cure of peptic ulcer by surgical measures, a voluminous literature, both medical and surgical, has been accumulated. It is now the consensus of opinion that the problem of the treatment of peptic ulcer is primarily a medical one, assuming surgical significance only with its complications, sequelae and intractable chronicity. The aim of treatment has been to secure a healing of the ulcer or its eradication with a correction of the pathological defects caused by it, together with the institution of such measures... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisville, Kentucky*Presented at the St. Louis meeting of the American College of Physicians, April 20, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1937Volume 11, Issue 5Page: 762-767KeywordsPeptic ulcersUlcers ePublished: 1 December 2008 Issue Published: 1 November 1937 PDF downloadLoading ...
Supreme Court rejects challenge to Affordable Care Act
Authors: M. McCarthy
Journal: BMJ (2015)

The US Supreme Court has rejected by six votes to three a challenge to the Affordable Care Act that, had it succeeded, threatened to upend the 2010 health legislation.1

In the challenge four plaintiffs had argued that the law did not authorize the US Internal Revenue Service to use tax credits to subsidize premiums for health insurance plans purchased through the health exchange run by the federal government, HealthCare.gov.

The challenge focused on a six word phrase in the 900 page law that authorized tax credits for premiums purchased through “an Exchange established by the State.”2 A plain reading of those words, the plaintiffs contended, authorizes tax credits for state run exchanges only, not for the exchange established by the federal government.

Thirty six states decided not to set …
Computer-based interview for screening blood donors for risk of HIV transmission
Authors: S. E. Locke
Journal: JAMA (1992)

<h3>Objective.</h3> —To test the ability of a computer-based interview to detect factors related to the risk of the human immunodeficiency virus (HIV) among potential blood donors and to determine donor reactions to the use of the interview. <h3>Design.</h3> —A comparison of the rate of detection of HIV-related factors elicited by a computer interview with that obtained by standard American Red Cross procedures for assessment of donor suitability, including a randomized crossover trial in which the order of the two methods was reversed. Information obtained by the computer was not available to influence the use of blood components for transfusion. <h3>Setting.</h3> —The computer interview was administered to donors at an American Red Cross blood donor center and at a mobile blood drive at a hospital. <h3>Subjects.</h3> —Consecutive sample of 294 male and female blood donors 18 to 75 years of age. <h3>Main Outcome Measures.</h3> —Subjects' responses to the computer-based interview as well as responses to the standard Red Cross written questionnaires and face-to-face interviews were used for donor assessment. <h3>Results.</h3> —The interview took an average of 8 minutes to complete. From among 272 donors who provided complete data, the computer identified 12 donors who reported either behaviors associated with a risk of HIV acquisition or symptoms compatible with the acquired immunodeficiency syndrome; none of these donors had been so identified either by routine written questionnaires or by face-to-face interviews used to screen potential blood donors. Only one of the 12 identified donors used the confidential unit exclusion procedure to prevent use of his donated unit. The rate of elicitation of HIV-related factors by the computer interview was 12 (4.4%) of 272 (95% confidence interval [Cl], 2.3% to 7.6%), compared with two (0.13%) of 1536 (95% confidence upper bound, 0.28%) using the standard Red Cross procedure (<i>P</i>&lt;.0001). Tests for antibodies to HIV were negative in blood samples from all of the 272 subjects studied. The subjects enjoyed the computer interview and judged it to be more private than the standard donor assessment method. They also predicted that donors would be more honest with the computer interview than with a human interviewer. <h3>Conclusions.</h3> —Computer-based screening elicits more HIV-related factors in the health histories of blood donors than do the standard questionnaire and interviewing methods currently in use. Computer-based screening is also acceptable to blood donors. (<i>JAMA</i>. 1992;268:1301-1305)
Impact of life events on subjects with panic disorder and on comparison subjects
Authors: Ronald M. Rapee, Eric M. Litwin, David H. Barlow
Journal: American Journal of Psychiatry (1990)

A questionnaire measure of major life events was given to 64 subjects with diagnoses of panic disorder with agoraphobia, 33 subjects with other anxiety disorders, and 34 nonanxious subjects. Anxious subjects indicated the life events that had occurred in the 6-month period immediately before their current disorder began and rated the impact of each event on a 7-point scale. Nonanxious subjects made the same ratings for a 6-month period 1 1/2-2 years before the study. There was no significant difference between groups in the number of life events reported. However, anxious subjects rated these events as having a significantly greater negative impact than did nonanxious subjects.
Evolution of the American College of Cardiology/American Heart Association Clinical Guidelines
Authors: Henry Han, Howard Chao, Andres Guerra, Alan Sosa, Georgios Christopoulos, Georgios E. Christakopoulos, Bavana V. Rangan, Spyros Maragkoudakis, Hani Jneid, Subhash Banerjee, Emmanouil S. Brilakis
Journal: Journal of the American College of Cardiology (2015)
Abstract 1536: Sex Specific Effects of Habitual Aerobic Exercise on Brachial Artery Flow-Mediated Dilation in Middle-Aged and Older Adults
Authors: Gary L Pierce, Iratxe Eskurza, Ashley E Walker, Tara N Fay, Douglas R Seals
Journal: Circulation (2009)

Background: Brachial artery endothelium-dependent dilation (flow-mediated dilation, FMD) is impaired with aging and is associated with increased risk for cardiovascular disease (CVD). Interventions that improve brachial artery FMD may help prevent age-related CVD. The purpose of this study was to determine if regular aerobic exercise increases brachial artery FMD in healthy middle-aged/older (ma/o) men and postmenopausal women. Methods: In a randomized controlled prospective study, non-obese (body mass index <30 kg/m2) ma/o previously sedentary adults (n=36, age 55–79 years) without CVD were studied before and after 8-weeks of vigorous daily walking (n=26, age 63±1 yrs) or non-exercise control (n=10, age 60±1 yrs). In a cross-sectional analysis, healthy ma/o sedentary (n=102, age 62±1 yrs) and endurance exercise-trained (n=65, age 62±1 yrs) men and postmenopausal women were studied. Results: Daily vigorous walking (~6 days/week, ~50 min/day, ~70% maximal heart rate) increased treadmill exercise time by ~2...
Abstract P058: Elevated Systolic Blood Pressure is Associated with Mortality in Faster, but Not Slower Walking Elderly Adults
Authors: Michelle C Odden, Carmen A Peralta, Mary N Haan, Kenneth E Covinsky
Journal: Circulation (2012)

Introduction: The association between high blood pressure (BP) and risk of death varies by age and appears to be attenuated in some elderly adults. Walking speed is an excellent measure of functional status and may identify which elders may be most at risk for the adverse consequences of hypertension. Hypothesis: We hypothesized that elevated BP would be associated with greater risk of mortality in faster walkers, but not in slower walkers. Methods: The study population included 2,340 persons ≥ 65 years, with measured BP, in the National Health and Nutrition Examination Survey (NHANES) waves 1999-2000 and 2001-2002. Mortality data was linked to death certificate data in the National Death Index. Walking speed was measured over a 20-foot walk; 243 (8%) did not complete the walk for various safety and logistical reasons. Participants with walking speed above the mean (2.7 ft/sec) were classified as faster walkers. Potential confouders included age, sex, race, survey year, lifestyle and physiologic factors, chronic health conditions, and antihypertensive use. Results: There were 589 deaths recorded through December 31 st , 2006. Among faster walkers, those with elevated systolic BP (≥140 mmHg) had a higher mortality rate compared to those with systolic BP &lt;140 mmHg (236 vs. 161 per 100,000 person-years). Among slower walkers, mortality rates did not appear to differ by the presence of elevated systolic BP (586 vs. 563 per 100,000 person-years). This pattern remained after multivariable adjustment; there was an association between elevated systolic BP and mortality in faster, but not slower walkers (Table). Elevated diastolic BP was not independently associated with an increased risk of mortality. Conclusions: If confirmed in other studies, walking speed could be a simple measure to identify elderly adults who are most at risk for poor outcomes related to high blood pressure. Table Association of elevated blood pressure and mortality, stratified by walking speed Hazard Ratio (HR) of Death Faster Walking Speed &gt;2.7 ft/sec (n = 1,279) Slower Walking Speed ≤ 2.7 ft/sec (n = 818) p-value for interaction HR (95% CI) p-value HR (95% CI) p-value Elevated Systolic BP (≥140 mmHg) 1.44 (1.04, 1.99) 0.03 1.08 (0.82, 1.42) 0.56 0.11 Elevated Diastolic BP (≥90 mmHg) 1.09 (0.52, 2.27) 0.82 0.65 (0.30, 1.45) 0.28 0.28 Funding (This research has received full or partial funding support from the American Heart Association, Western States Affiliate (California, Nevada&amp;Utah))
Abstract 17289: Hypoxia-Inducible Factor Gene Polymorphisms and Right Ventricular Adaptation in Children After Tetralogy of Fallot Repair
Authors: Aamir Jeewa, Luc Mertens, Cedric Manlhiot, Brian W McCrindle, Andrew Redington, Glen Van Arsdell, Seema Mital
Journal: Circulation (2010)

Chronic pulmonary insufficiency (PI) after tetralogy of Fallot (TOF) repair results in right ventricular (RV) dilation, RV dysfunction and arrhythmias. Hypoxia and mechanical stress increase hypoxi...
A Two-Year Follow-Up Of a Prospective Study Of Intensified Conditioning Regimen With High-Dose-Etoposide Allogeneic Hematopoietic Stem Cell Transplantation For Adult Acute Lymphoblastic Leukemia In China
Authors: Hongsheng Zhou, Zhiping Fan, Fen Huang, Yu Zhang, Min Dai, Na Xu, Guopan Yu, Dan Xu, Qianli Jiang, Jing Sun, Qifa Liu
Journal: Blood (2013)