tbuckley/cabot-search huggingface dataset:
Sterility: The Diagnostic Survey of the Infertile Couple.
Authors: Walter W. Williams
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Essentials of Surgery. Together with a Full Description of the Handkerchief and Roller Bandage. Arranged in the Form of Questions and Answers Prepared Especially for Students of Medicine
Authors: Edward Martin
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment With Leukapheresis In Patients Diagnosed With Hyperleukocytic Acute Myeloid Leukemia
Authors: David Martínez-Cuadrón, Pau Montesinos, Federico Moscardo, Lineth Lopez, Guillermo Martin, Pilar Solves, Blanca Boluda, Mariluz Pérez-Sirvent, Belen Vera, Ines Navarro, Carmen M Alonso, Jesus Martinez, Francisca López-Chulia, Jaime Sanz, Nelly Carpio, Rebeca Rodríguez-Veiga, Gloria Iacoboni, Guillermo Sanz, Miguel Sanz
Journal: Blood (2013)
Les maladies de l'énergie: Les asthénies et la neurasthénie.
Authors: Albert Deschamps, Jean Vinchon
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Congress of Psychotherapy – Internationaler Kongress für Psychotherapie – Congrès International de Psychothérapie
Authors: Joseph L. Henderson, Franz Alexander, M. Boss, Walter Gut, Daniel Lagache, Joshua Bierer, John Nathaniel Rosen, Gerdhild Staabs, K. Goldstein, R. Sarro Burbano, K. Graf Dürckheim
Journal: Psychotherapy and Psychosomatics (1954)
Trends in emergency psychiatry in the last two decades
Authors: J H Bristol, E Giller, J P Docherty
Journal: American Journal of Psychiatry (1981)

Emergency psychiatric services provide essential care. Their utilization may also be assumed to reflect the health care needs of a population. The authors observed trends in an emergency psychiatric service over a 17-year period by comparing 400 randomly selected patient visits in 1977 with date from 1960 and 1970. They found a decrease in the number of patients seeking treatment, decreased patient age and socioeconomic status, increased use by men, increased night visits, little change in diagnostic categories, and a striking increase in hospitalization since 1970. These data support the importance of assessing trends in emergency psychiatric services over time to ensure that they meet the needs of the population being served.
Capitalism Carries On
Authors: Walter B. Pitkin
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of mTOR inhibitors on sorafenib-induced endoplasmic reticulum stress and apoptosis in melanoma cells.
Authors: F. E. Meier, D. Beck, H. Niessner, K. T. Flaherty, T. Sinnberg, D. Schadendorf, D. Kulms, C. Garbe
Journal: Journal of Clinical Oncology (2010)

e19027 Background: In melanoma, the RAF-MEK-ERK (MAPK) and the PI3K-AKT-mTOR (AKT) signaling pathways are constitutively activated and have key functions in tumor progression. In our previous studies, combination of the nonselective RAF inhibitor sorafenib with the mTOR inhibitor sirolimus significantly potentiated growth inhibition and led to an approximately 2-fold increase of apoptosis of melanoma cells in monolayer culture compared with sorafenib monotreatment (p<0.05). Moreover, sorafenib in combination with sirolimus completely suppressed invasive melanoma growth in organotypic culture. Methods: To investigate the molecular mechanisms involved in the antitumoral action of this drug combination we analyzed the gene expression profile of melanoma cells in response to sorafenib or/and sirolimus. Results: Data analysis showed a series of genes (p8, ATF4/3, CHOP, TRB3) that were upregulated after treatment with sorafenib and sirolimus and have been proposed to be responsible for the execution of endoplasmic reticulum (ER) stress-induced apoptosis. Using real-time quantitative PCR, we confirmed that sorafenib and sirolimus upregulate p8, ATF4/3, CHOP and TRB3 mRNA levels in melanoma cells. Likewise, western blot analysis showed that sorafenib and sirolimus increase p8 and CHOP protein levels. Furthermore, the farnesyl transferase inhibitor lonafarnib inhibiting mTOR signaling also augmented sorafenib-induced apoptosis and upregulation of the ER stress-related transcription factor p8. Of note, growth inhibitory effects and upregulation of ER stress-related genes by sorafenib and sirolimus or lonafarnib did not depend on BRAF or NRAS mutation status. By contrast, the BRAFV600E kinase inhibitor PLX4032 potently inhibited growth and upregulated the ER stress-related transcription factor p8 preferentially in BRAFV600E melanoma cells. Conclusions: These data suggest that mTOR inhibitors enhance sorafenib-induced endoplasmic reticulum stress and apoptosis in melanoma cells. No significant financial relationships to disclose.
The Combination Of JAK Inhibitor, Ruxolitinib, and PIM Inhibitor, LGH447, In Preclinical Models Of Myeloproliferative Neoplasia
Authors: Abdel Saci, Maria Pinzon-Ortiz, Dannie Wang, Xianhui Rong, Joseph Growney, Margaret Squier, Thomas Radimerski, K. Gary Vanasse, Giordano Caponigro, Pablo D Garcia, Z. Alexander Cao
Journal: Blood (2013)
Expanding consensus in portal hypertension
Authors: Roberto de Franchis
Journal: Journal of Hepatology (2015)

Portal hypertension is the haemodynamic abnormality associated with the most severe complications of cirrhosis, including ascites, hepatic encephalopathy and bleeding from gastroesophageal varices. Variceal bleeding is a medical emergency associated with a mortality that, in spite of recent progress, is still in the order of 10–20% at 6weeks. The evaluation of diagnostic tools and the design and conduct of good clinical trials for the treatment of portal hypertension have always been difficult. Awareness of these difficulties has led to the organisation of a series of consensus meetings.
Abstract 15418: Impact of Chronic Statin-Pretreatment on Myocardial Damage as Assessed by Cardiac Magnetic Resonance Findings in Patients with Acute ST-Elevation Myocardial Infarction
Authors: Georg F Fuernau, Ingo Eitel, Steffen Desch, Suzanne de Waha, Gerhard Schuler, Holger Thiele
Journal: Circulation (2011)

Background Recent data have demonstrated a lower mortality in acute ST-elevation myocardial infarction (STEMI) patients with previous treatment with statins, especially in patients with high risk p...
Abstract 19116: Depletion of T Lymphocytes Exerts Cardioprotection and Antifibrotic Effect in Streptozotocin-Induced Type 1 Diabetic Mice
Authors: Chowdury S Abdullah, Zhao Li, Zhu-Qiu Jin
Journal: Circulation (2013)

Background and Aims: T lymphocytes infiltration into myocardium has been observed in both type 1 and type 2 diabetic patients. However, effects of T cells on cardiac function and survival as well as fibrosis in a diabetic model remain to be determined. Methods: In this study, depletion of T cells was achieved by using pharmacological approach (fingolimod, a sphingosine 1-phosphate receptor modulator) and genetic approach (Rag1 knockout mice without mature lymphocytes). Type 1 diabetes was induced by intraperitoneal injection of streptozotocin (STZ) for five consecutive days with small dose (50 mg/kg) in both C57BL/6J mice and Rag1 mutant mice. Treatment with Fingolimod (0.3 mg/kg/day, i.p.) was performed in STZ diabetic mice. Body weight of mice was monitored twice a week. Fasting blood glucose level was detected after 4 weeks and 11 weeks of STZ administration. At the end of 11 weeks, blood T cells (CD4+ and CD8+) counting was conducted with flow cytometry. Serum insulin content was measured with ELISA. Infiltration of T cells (CD3+ positive staining) into the myocardium of mice was observed with immunohistochemistry method in paraffin sections. The fibrosis of myocardium was quantified by using trichrome staining. Cardiac contractile force was recorded with Langendorff heart perfusion system. Apoptosis of hearts was detected with TUNEL staining. Results: Fingolimod had no effects on body weight and glucose level (478+/-20 mg/dl vs 426+/-34 mg/dl in vehicle group, p=n.s.). Fingolimod significantly reduced the blood T cells (CD4+ cells: 0.16+/-0.12% vs 7.07+/-0.68% in vehicle group, P&lt;0.01, n=4-5 per group) in C57BL/6J mice. Fingolimod also enhanced cardiac contractility and reduced fibrosis as well as apoptosis of the myocardium in C57BL/6J mice. Compared to wild-type (B6), Rag1 mutant mice remained the high blood glucose level in STZ model (447+/-36 mg/dl, n=11). However, cardiac fibrosis was reduced and cardiac contractile force was enhanced in Rag1 mutant mice. Conclusions: Depletion of T cells in the circulation with pharmacological agent-Fingolimod or Rag1 mutation without mature lymphocytes renders hearts more resistant to the cardiac injury caused by diabetes.
Tumors of the Cardiovascular System
Authors: Benjamin H. Landing, Sidney Farber
Journal: Annals of Internal Medicine (1958)

Book reviews 99 grafts.There is a section on experimental work on the treatment of aplastic anaemia by ALG and a section on clinical bone marrow transplantation.This covers histocompatibility testing and the H-Y immunity phenomenon.The clinical results of marrow grafting for aplasia, leukaemia, and immune deficiency are reported from Seattle, UCLA, and Paris, but they are already out of date.The final section of the book is a mixed bag called 'Advances in Experimental Haematology' covering a variety of topics including preservation of dog granulocytes and diffusion chamber cul- tures.All in all this is a specialised book providing suitable reading for the growing number of experimental haematologists concerned with investigating new approaches to understanding and treating leukaemia, aplastic anaemia, and immune deficiencies.It is a good memento of the conference but, like all proceedings, its useful life must be measured in months not years.It is not for the uninitiated who would do better to wait for a definitive review on the last decade of experimental haematological research.
Editorial
Authors: Ajit P Varki
Journal: Journal of Clinical Investigation (1996)

This spring will mark the inauguration of a new kind of biomedical research meeting entitled "Biomedicine '96: Medical Research from Bench to the Bedside" (see the advertisement in this issue).As announced recently (1), the traditional spring Clinical Research Meeting will be transformed by a newly established co-operation with the journal SCIENCE , thus broadening the scope and impact of the event.This association is
Not again!
Authors: P. J B. Smith
Journal: BMJ (2001)

Thalamic cells that relay vibrissa information to barrel cortex are clustered within whisker-related modules termed barreloids. Each barreloid receives input from one principal whisker and inhibitory inputs from reticular thalamic neurons with receptive fields that correspond to that same whisker. Although the proximal dendrites of relay cells are confined to their home barreloid, distal dendrites often extend into surrounding barreloids representing adjacent whiskers on the mystacial pad. It was proposed that this arrangement provides a substrate for a mechanism of lateral inhibition that operates remotely on extrabarreloid dendrites. In the present study, we identified adjacent whiskers that suppressed activity below background levels in barreloid cells, and we used a double-labeling protocol to relate the efficacy of inhibition to the dendroarchitecture of the cells. Significant suppression of background discharges was produced by 92% of adjacent whiskers within rows, by 48% of adjacent whiskers within arcs, but was never observed after deflection of nonadjacent whiskers. The magnitude of lateral inhibition increases linearly as the cumulated length of dendrites increases in the barreloid representing an adjacent whisker (<i>R</i><sup>2</sup> = 0.86; <i>p</i> &lt; 0.0001). As distance between cell bodies and the border of an adjacent barreloid increases, dendritic length in that adjacent barreloid diminishes and so does inhibition. Considering time differences between the arrival of principal and adjacent whisker inputs in barreloids, our data suggest that inhibition operating distally on dendrites acts as a spatial filter that primarily suppresses adjacent whisker inputs and so contributes to enhance edge detection.
Concurrent chemoradiotherapy for locally advanced cervical esophageal carcinoma: A phase II study of oral fluoropyrimidine agents (UFT, S-1) plus cisplatin with radiotherapy
Authors: H. Iwase, M. Shimada, T. Tsuzuki, N. Hirashima, H. Goto
Journal: Journal of Clinical Oncology (2009)

6043 Background: Carcinoma of the cervical esophagus is a highly virulent disease. Although surgery is the standard therapy, the results of surgery alone are poor. Oral fluoropyrimidines (UFT, S-1) are useful to treat head and neck cancer and enhance the effectiveness of radiotherapy. We evaluated concurrent chemoradiotherapy using an oral fluoropyrimidine (UFT, S-1) and cisplatin in patients with locally advanced cervical esophageal carcinoma. Methods: Chemoradiotherapy with UFT and cisplatin (R-U-P) consisted of 60Gy of radiotherapy during 6 weeks, with daily UFT (200 mg/m 2 /day) and a 24-h infusion of cisplatin (70 mg/m 2 ) on Days 8 and 36. Chemoradiotherapy with S-1 and cisplatin (R-S-P) consisted of two courses. One included 30 Gy of radiotherapy over 3 weeks, with daily S-1 (80 mg/m 2 /day) for 2 weeks and a 24-h infusion of cisplatin (70 mg/m 2 ) on Day 8. The other included chemoradiotherapy after 2 weeks. Responders received at least 2 four-week courses of the chemotherapy. Results: Twenty patients were enrolled: 8 were treated with R-U-P and 12 with R-S-P. Four patients had stage II tumors and 16 had stage III tumors. All patients completed the chemoradiotherapy. The most prominent toxicity was myelosuppression. Grades 3 and 4 leukocytopenia occurred in 5 (25%) and 2 (10%) patients, respectively. Nonhematologic toxicity was moderate: grade 2 nausea/vomiting, pain, oral mucositis, and renal dysfunction occurred in 25%, 25%, 20% and 10% of the patients, respectively. Complete response (CR) was attained in all 4 patients with stage II tumors. In stage III cases, CR, partial response (PR), and response rates were 81%, 13%, and 94%, respectively these reached 75%, 17%, and 92% in the R-U-P group, and 90%, 10%, and 100% in the R-S-P group, respectively. All stage II patients survived. In stage III cases, the one-year survival rate was 75% and the three-year survival rate was 50%. Conclusions: Chemoradiotherapy with an oral fluoropyrimidine (UFT, S-1) plus cisplatin is convenient, tolerable, and effective, and it is a promising nonsurgical management option for patients with locally advanced cervical esophageal carcinoma. No significant financial relationships to disclose.
Cell-Mediated Immune Response of Ragweed-Sensitive Patients to Ragweed Antigen E
Authors: Ross E. Rocklin, Hobert Pence, Hyman Kaplan, Richard Evans
Journal: Journal of Clinical Investigation (1974)

The in vivo and in vitro responses to ragweed antigen E were evaluated in 28 untreated atopic patients with ragweed hayfever. The methods employed included direct skin testing, measurement of total serum IgE, measurement of specific IgE anti-ragweed antibodies, leukocyte histamine release, lymphocyte transformation, and release of lymphocyte mediators (migration inhibitory factor and mitogenic factor). The patients could be divided into sensitive and insensitive groups on the basis of their in vitro reactivity to antigen E. 20 patients in the sensitive group had statistically higher levels of total serum IgE, higher levels of specific IgE anti-ragweed antibodies, and greater leukocyte sensitivity as measured by antigen-induced histamine release than did eight patients in the insensitive group. Lymphocytes from sensitive patients produced greater amounts of migration inhibitory factor and mitogenic factor when challenged by antigen E than did lymphocytes from insensitive patients. A possible role for the lymphocyte in this allergic disease is discussed. The results of this study indicate that the immune response to ragweed antigen is complex and involves components of both immediate and delayed hypersensitivity.
FAT METABOLISM IN DIABETES MELLITUS
Authors: William C. Stadie
Journal: Annals of Internal Medicine (1941)

Article1 November 1941FAT METABOLISM IN DIABETES MELLITUSWILLIAM C. STADIE, M.D.WILLIAM C. STADIE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-5-783 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe enormous amount of research on the abnormal metabolic processes of diabetes mellitus since the time of v. Mehring and Minkowski has failed to bring unity of conviction to students of the disease. We find today, as in earlier times, two opposing hypotheses still striving for supremacy. These two hypotheses may be briefly stated as follows:I. The under-utilization hypothesis states that the major defect in the intermediary metabolism of the diabetic is the inability of the tissues to oxidize sufficient carbohydrate for normal metabolic needs. In consequence, ingested carbohydrate and that derived from protein is excreted.II. The over-production... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Read at the Boston meeting of the American College of Physicians April 21, 1941.From the Department of Research Medicine, University of Pennsylvania. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Intermediary Stages in the Biological Oxidation of CarbohydrateDiscussionThe response of blood glucose, ketones, and plasma nonesterified fatty acids to fasting and epinephrine injection in infants and childrenIntroductionDiabetic ComaThe Treatment of Diabetic Acidosis and Diabetic ComaA plan of treatment for diabetic acidosis 1 November 1941Volume 15, Issue 5Page: 783-797KeywordsCarbohydrate metabolismCarbohydratesDiabetes mellitusFatsMetabolic processesProteins ePublished: 1 December 2008 Issue Published: 1 November 1941 Copyright & PermissionsCopyright, 1941, by The American College of PhysiciansPDF downloadLoading ...