tbuckley/cabot-search huggingface dataset:
Rendezvous-assisted endoscopic retrograde pancreatography in groove pancreatitis with a nondilated pancreatic duct
Authors: Yawen Liang, Huikai Li, Ke Meng, Baoguo Bu, Yaqi Zhai, Mingyang Li
Journal: Endoscopy (2024)

A 66-year-old man with a history of alcoholism was referred to our center due to recurrent pancreatitis. Previous surgical exploration with biopsies demonstrated the benign nature of a pancreatic head mass. Enhanced computed tomography (CT) and magnetic resonance cholangiopancreatography (MRCP) revealed a thickened descending duodenum, inflammation in the groove area, and cyst-solid lesion in the pancreatic head, suggesting groove pancreatitis ([Fig. 1]).
Large defect closure using a helix tacking system and endoclips after endoscopic submucosal dissection of two adjacent colonic lesions
Authors: Elena De Cristofaro, Pierre Lafeuille, Jérôme Rivory, Jeremie Jacques, Rosario D'Almeida, Alexandru Lupu, Mathieu Pioche
Journal: Endoscopy (2024)

Endoscopic resection of gastrointestinal neoplasia, especially endoscopic submucosal dissection (ESD), is increasingly common, but poses risks of complications including bleeding and perforation, which can be prevented by closing the defect. Conventional through-the-scope (TTS) clips are typically effective for successful closure of linear defects up to 2 cm in diameter [1]. For larger defects over-the scope (OTS) clips can be used, but incorrect placement complicates the use of other devices. The OverStitch OTS suturing system can achieve full-thickness closure [2]. Nevertheless, it can be used only with a gastroscope, which must be removed to assemble the device. The X-Tack Endoscopic HeliX Tacking System is a novel TTS device designed for endoscopic approximation of soft tissue through a standard gastroscope or colonoscope [3]. Several case reports have demonstrated its efficacy in closing large mucosal defects [4] [5]. Herein, we present the combined use of the X-Tack with TTS clips to close a large defect following ESD ([Video 1]).
An evaluation of psychosocial sleep interventions for children with chronic health conditions: A systematic review
Authors: Laurie McLay, Jolene Hunter, Kimberly Ballam, Lisa Marie Emerson, Andrew S. Day, Moya Vandeleur, Samuel Dalton, Zoe Radcliffe, Emma Woodford
Journal: Sleep Medicine Reviews (2024)

Chronic health conditions (CHC; e.g., cystic fibrosis, type 1 diabetes) in children are associated with disease-specific physical symptoms that contribute to a high prevalence of sleep problems. Sleep problems exacerbate other health-related sequelae and can impede therapeutic response to health treatments, increasing the overall complexity of symptom management. Psychosocial sleep interventions (PSI) improve sleep in children with typical development and neurodevelopmental conditions. Yet, the effectiveness of PSI for children with CHC has scarcely been investigated. This systematic review appraises the literature examining the effectiveness and acceptability of PSI for children with CHC. A search identified 20 studies that met inclusion criteria. Data related to participant characteristics, sleep targets, research design and methods, measures, sleep outcomes and collateral effects were extracted. Study rigor was then evaluated. Most studies evaluated youth-directed Cognitive Behavioral Therapy for Insomnia or parent-implemented behavioral sleep interventions. Twelve studies demonstrated positive sleep treatment effects and four demonstrated mixed effects. Collateral improvements were reported in child mental health and parental health and well-being, though physical health benefits for children were not consistently reported. One, five and 14 studies were rated as having strong, adequate, and weak methodological rigor respectively. Recommendations for clinical practice and future research are made.
Combination of a permanent slow flow managed by the nurse and a rapid flow for bleeding management controlled by the doctor in underwater endoscopic submucosal dissection
Authors: Auxane Chauveau, Soline Brun, Marina Cornelis, Muriel Deschamp, Laetitia Chevrot, Mikael Mochet, Mathieu Pioche
Journal: Endoscopy (2024)

Endoscopic submucosal dissection (ESD) is enjoying enormous growth, driven largely by all the technical innovations aimed at making it easier, safer, and faster [1]. Among the various means of facilitating submucosal exposure, floating the lesion to be resected in underwater dissection has become a precious technical aid in difficult cases, particularly when gravity is unfavorable for the situation [2] [3].
Endoscopic submucosal dissection using the tunneling method for early gastric cancer occupying the entire fornix
Authors: Yohei Yabuuchi, Soichiro Nagao, Shuko Morita, Tetsuro Inokuma
Journal: Endoscopy (2024)

The location of the fornix is challenging for endoscopic submucosal dissection (ESD) because of its difficult access, tendency to face vertically, and submersion in the gastric fluid and blood. To overcome these issues, the use of a multi-bending scope, multiple clip-line tractions, and right lateral position have been reported [1] [2] [3]. However, even with these strategies, treating lesions occupying the entire fornix remains challenging because adverse events such as perforation have been reported [4]. We describe a successful ESD for early gastric cancer occupying the entire fornix using the tunneling method, allowing us to approach the most difficult-to-reach area from a tangential direction and achieve resection without adverse events.
Submucosal tunneling endoscopic resection technique with intermuscular dissection for a rectal gastrointestinal stromal tumor
Authors: Salvatore Russo, Silvia Cocca, Flavia Pigò, Giuseppe Grande, Stefania Caramaschi, Rita Conigliaro, Helga Bertani
Journal: Endoscopy (2024)

A 54-year-old woman was referred to our center for evaluation of a subepithelial tumor located in the posterior wall of the rectum, 1 cm proximal to the anal verge. Endoscopic ultrasonography showed a 15-mm hypoechoic homogeneous submucosal lesion. Submucosal tunneling endoscopic resection (STER) was performed ([Video 1]) under monitored anesthesia care, using CO2 insufflation, a standard gastroscope (GIF-H190) with a transparent cap (D-201-10704), DualKnife J 1.5 mm (Olympus, Tokyo, Japan), and a VIO 200D (Erbe, Tübingen, Germany). The submucosal lift was achieved with a mixture of saline solution and indigo carmine. A small horizontal incision was made at the distal margin and a submucosal pocket was created. After dissecting the subepithelial tumor from the submucosa ([Fig. 1]), an intermuscular dissection assisted by a water-jet injection into the intermuscular space was performed ([Fig. 2], [Fig. 3]). Finally, the larger vessels were coagulated with a bipolar forceps (HS-D2622; Pentax, Tokyo, Japan) and the mucosal defect was closed with four 11-mm through-the-scope clips (MED-204-CLP; Meditalia, Palermo, Italy). The technical duration of the procedure was 30 minutes. The patient was discharged 2 hours later with the indication to take prophylactic oral antibiotic therapy for 5 days. No complications were reported. Histology showed a 12-mm gastrointestinal stromal tumor (GIST) surrounded by thin smooth tissue, with free margins (R0) and mitotic index <5/mm2 ([Fig. 4]).
A swirl ERCP during combined endoscopic-radiological-surgical management of a late-onset post-traumatic obstructive jaundice
Authors: Giacomo Emanuele Maria Rizzo, Lucio Carrozza, Salvatore Gruttadauria, Alessandro Bertani, Roberto Miraglia, Ilaria Tarantino, Mario Traina
Journal: Endoscopy (2024)

A 47-year-old man suffered diaphragmatic laceration in a road trauma around the age of 30, with associated thoracic herniation of the right colon and part of the duodenum, atelectasis of the right lower lung lobe with median dislocation of the liver, atrophy of the right liver lobe, and compensatory hypertrophy of the left liver lobe. After 15 years, he developed an episode of cholestasis and jaundice, and was admitted to another center for initial evaluation, involving viral and serological screening for liver causes of jaundice, including the reported intake of ibuprofen. All evaluations were negative, so abdominal contrast-enhanced computed tomography (CT) scan was performed and showed dilation of the common bile duct (CBD) and intrahepatic biliary ducts (IBDs), without evidence of lithiasis and/or pathological interruptions. Liver biopsy was performed and histological evaluation was suspicious for "vanishing bile duct syndrome," so oral steroid therapy was started, but had no clinical benefit.
Innovative endoscopic combination surgery for endoscopic submucosal dissection using two thin therapeutic endoscopes
Authors: Takuma Okamura, Tomonari Ikeda, Kazuyoshi Nagata, Tatsuki Ichikawa, Kazuhiko Nakao
Journal: Endoscopy (2024)

Endoscopic procedures are complicated and difficult to perform because they are performed using a single endoscope. Although double-scope endoscopic submucosal dissection (ESD) with an ultrathin endoscope and a normal-diameter endoscope or two normal-diameter endoscopes has been used [1], problems arise, such as reduced operability due to interference between the scope and the limited instruments that can be used. Recently, a narrow endoscope (EG-840TP, FUJIFILM, Tokyo, Japan) was developed and reported to be useful for endoscopic resection [2] [3] with a relatively narrow 7.9-mm outer diameter and a large 3.2-mm accessory channel. We devised a thin endoscopic combination surgery that uses two thin therapeutic scopes to reduce the effects of mutual interference and allow free movement. This allows the two instruments to be moved independently and simultaneously, as in laparoscopic surgery, or observed and assisted by an assistive scope that does not perform the procedure, to ensure that the procedure is targeted to the appropriate location. Here, we performed endoscopic submucosal dissection of a large rectal tumor using thin endoscopic combination surgery ([Fig. 1], [Fig. 2]; [Video 1]). The operator performed the resection with a knife, while the assistant assisted with local injection, real-time traction to the required area using grasping forceps, and aspiration of accumulated water ([Fig. 3]). Because the field of view can be freely developed, we do not need to dive into the submucosa or attach the tip. We achieved en bloc resection within 159 min without any adverse events. After resection, most large tumors are difficult to retrieve; however, the tumor can be easily stored in an endoscopic retrieval bag (ENDO CARRY, Hakko, Tokyo, Japan) as a laparoscope using thin endoscopic combination surgery, and the resected specimen can be retrieved without damage ([Fig. 4]).
Endoscopic transpapillary gallbladder drainage using a novel drill dilator
Authors: Jun Noda, Yuichi Takano, Masataka Yamawaki, Tetsushi Azami, Fumitaka Niiya, Fumiya Nishimoto, Masatsugu Nagahama
Journal: Endoscopy (2024)

In endoscopic transpapillary gallbladder drainage (ETGBD), device insertion through the cystic duct to the gallbladder is challenging [1]. Even if a guidewire can be placed in the gallbladder, the device cannot be inserted due to stone or inflammation of the cystic duct in some cases [2] [3]. We experienced a case in which ETGBD was successfully performed using a novel drill-type dilator ([Fig. 1]).
The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1
Authors: Vasileios Oikonomou, Grace Smith, Gregory M Constantine, Monica M Schmitt, Elise M N Ferré, Julie C Alejo, Deanna Riley, Dhaneshwar Kumar, Lucas Dos Santos Dias, Joseph Pechacek, Yannis Hadjiyannis, Taura Webb, Bryce A Seifert, Rajarshi Ghosh, Magdalena Walkiewicz, Daniel Martin, Marine Besnard, Brendan D Snarr, Shiva Deljookorani, Chyi-Chia R Lee, Tom DiMaggio, Princess Barber, Lindsey B Rosen, Aristine Cheng, Andre Rastegar, Adriana A de Jesus, Jennifer Stoddard, Hye Sun Kuehn, Timothy J Break, Heidi H Kong, Leslie Castelo-Soccio, Ben Colton, Blake M Warner, David E Kleiner, Martha M Quezado, Jeremy L Davis, Kevin P Fennelly, Kenneth N Olivier, Sergio D Rosenzweig, Anthony F Suffredini, Mark S Anderson, Marc Swidergall, Carole Guillonneau, Luigi D Notarangelo, Raphaela Goldbach-Mansky, Olaf Neth, Maria Teresa Monserrat-Garcia, Justo Valverde-Fernandez, Jose Manuel Lucena, Ana Lucia Gomez-Gila, Angela Garcia Rojas, Mikko R J Seppänen, Jouko Lohi, Matti Hero, Saila Laakso, Paula Klemetti, Vanja Lundberg, Olov Ekwall, Peter Olbrich, Karen K Winer, Behdad Afzali, Niki M Moutsopoulos, Steven M Holland, Theo Heller, Stefania Pittaluga, Michail S Lionakis
Journal: New England Journal of Medicine (2024)

Autoimmune polyendocrine syndrome type 1 (APS-1) is a life-threatening, autosomal recessive syndrome caused by autoimmune regulator (AIRE) deficiency. In APS-1, self-reactive T cells escape thymic negative selection, infiltrate organs, and drive autoimmune injury. The effector mechanisms governing T-cell-mediated damage in APS-1 remain poorly understood.
Brain–body states embody complex temporal dynamics
Authors: Daniel S. Kluger, Micah G. Allen, Joachim Gross
Journal: Trends in Cognitive Sciences (2024)

We propose a computational framework for high-dimensional brain–body states as transient embodiments of nested internal and external dynamics governed by interoception. Unifying recent theoretical work, we suggest ways to reduce arbitrary state complexity to an observable number of features in order to accurately predict and intervene in pathological trajectories.
Endoscopic vacuum therapy for esophageal perforations: size and etiology of the defect need to be considered
Authors: Valerio Pontecorvi, Andrea Tringali, Ivo Boskoski, Cristiano Spada
Journal: Endoscopy (2024)

Letter to: Endoscopic vacuum therapy for esophageal perforation: a multicenter retrospective cohort studyEndoscopy 2023; 55(09): 859-864DOI: 10.1055/a-2042-6707
Fertility Preservation and Assisted Reproduction in Patients With Breast Cancer Interrupting Adjuvant Endocrine Therapy to Attempt Pregnancy
Authors: Hatem A. Azim, Samuel M. Niman, Ann H. Partridge, Isabelle Demeestere, Monica Ruggeri, Marco Colleoni, Cristina Saura, Chikako Shimizu, Anna B. Saetersdal, Judith R. Kroep, Audrey Mailliez, Ellen Warner, Virginia F. Borges, Frédéric Amant, Andrea Gombos, Akemi Kataoka, Christine Rousset-Jablonski, Simona Borstnar, Junko Takei, Jeong Eon Lee, Janice M. Walshe, Manuel Ruíz-Borrego, Halle C.F. Moore, Christobel Saunders, Vesna Bjelic-Radisic, Snezana Susnjar, Fatima Cardoso, Natalie J. Klar, Tanja Spanic, Kathryn Ruddy, Martine Piccart, Larissa A. Korde, Aron Goldhirsch, Richard D. Gelber, Olivia Pagani, Fedro A. Peccatori
Journal: Journal of Clinical Oncology (2024)

We investigated time to pregnancy, efficacy and safety of fertility preservation, and assisted reproductive technologies (ARTs) in women with early hormone receptor-positive breast cancer (BC) desiring future pregnancy.
LACC Trial: Final Analysis on Overall Survival Comparing Open Versus Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer
Authors: Pedro T. Ramirez, Kristy P. Robledo, Michael Frumovitz, Rene Pareja, Reitan Ribeiro, Aldo Lopez, Xiaojian Yan, David Isla, Renato Moretti, Marcus Q. Bernardini, Val Gebski, Rebecca Asher, Vanessa Behan, Robert L. Coleman, Andreas Obermair
Journal: Journal of Clinical Oncology (2024)

JCO
The oral organ: A new vision of the mouth as a whole for a gerophysiological approach to healthy aging
Authors: Chiara Cecchin-Albertoni, Olivier Deny, Valérie Planat-Bénard, Christophe Guissard, Jenny Paupert, Frédéric Vaysse, Mathieu Marty, Louis Casteilla, Paul Monsarrat, Philippe Kémoun
Journal: Ageing Research Reviews (2024)

This article brings a new perspective on oral physiology by presenting the oral organ as an integrated entity within the entire organism and its surrounding environment. Rather than considering the mouth solely as a collection of discrete functions, this novel approach emphasizes its role as a dynamic interphase, supporting interactions between the body and external factors. As a resilient ecosystem, the equilibrium of mouth ecological niches is the result of a large number of interconnected factors including the heterogeneity of different oral structures, diversity of resources, external and internal pressures and biological actors. The manuscript seeks to deepen the understanding of age-related changes within the oral cavity and throughout the organism, aligning with the evolving field of gerophysiology. The strategic position and fundamental function of the mouth make it an invaluable target for early prevention, diagnosis, treatment, and even reversal of aging effects throughout the entire organism. Recognizing the oral cavity capacity for sensory perception, element capture and information processing underscores its vital role in continuous health monitoring. Overall, this integrated understanding of the oral physiology aims at advancing comprehensive approaches to the oral healthcare and promoting broader awareness of its implications on the overall well-being.
Proteomics profiling of extracellular vesicle for identification of potential biomarkers in Alzheimer's disease: A comprehensive review
Authors: JinJin Pei, Chella Perumal Palanisamy, Selvaraj Jayaraman, Prabhu Manickam Natarajan, Vidhya Rekha Umapathy, Jeane Rebecca Roy, Dwarakesh Thalamati, Rathi Muthaiyan Ahalliya, Gopalakrishnan Velliyur Kanniappan, Monica Mironescu
Journal: Ageing Research Reviews (2024)
Deep learning to assess microsatellite instability directly from histopathological whole slide images in endometrial cancer
Authors: Ching-Wei Wang, Hikam Muzakky, Nabila Puspita Firdi, Tzu-Chien Liu, Po-Jen Lai, Yu-Chi Wang, Mu-Hsien Yu, Tai-Kuang Chao
Journal: npj Digital Medicine (2024)

Abstract Molecular classification, particularly microsatellite instability-high (MSI-H), has gained attention for immunotherapy in endometrial cancer (EC). MSI-H is associated with DNA mismatch repair defects and is a crucial treatment predictor. The NCCN guidelines recommend pembrolizumab and nivolumab for advanced or recurrent MSI-H/mismatch repair deficient (dMMR) EC. However, evaluating MSI in all cases is impractical due to time and cost constraints. To overcome this challenge, we present an effective and efficient deep learning-based model designed to accurately and rapidly assess MSI status of EC using H&amp;E-stained whole slide images. Our framework was evaluated on a comprehensive dataset of gigapixel histopathology images of 529 patients from the Cancer Genome Atlas (TCGA). The experimental results have shown that the proposed method achieved excellent performances in assessing MSI status, obtaining remarkably high results with 96%, 94%, 93% and 100% for endometrioid carcinoma G1G2, respectively, and 87%, 84%, 81% and 94% for endometrioid carcinoma G3, in terms of F-measure, accuracy, precision and sensitivity, respectively. Furthermore, the proposed deep learning framework outperforms four state-of-the-art benchmarked methods by a significant margin ( p &lt; 0.001) in terms of accuracy, precision, sensitivity and F-measure, respectively. Additionally, a run time analysis demonstrates that the proposed method achieves excellent quantitative results with high efficiency in AI inference time (1.03 seconds per slide), making the proposed framework viable for practical clinical usage. These results highlight the efficacy and efficiency of the proposed model to assess MSI status of EC directly from histopathological slides.
Plasma immune signatures can predict rejection-free survival in the first year after pediatric liver transplantation
Authors: Evgeny Chichelnitskiy, Imeke Goldschmidt, Louisa Ruhl, Nicole Rübsamen, Veronika K. Jaeger, Andre Karch, Kerstin Beushausen, Jana Keil, Juliane K. Götz, Lorenzo D’Antiga, Dominique Debray, Loreto Hierro, Deirdre Kelly, Valerie McLin, Joanna Pawlowska, Rafael T. Mikolajczyk, Michela Bravi, Maja Klaudel-Dreszler, Zeynep Demir, Carla Lloyd, Simona Korff, Ulrich Baumann, Christine S. Falk
Journal: Journal of Hepatology (2024)

After pediatric liver transplantation (pLT), children undergo life-long immunosuppression since reliable biomarkers for the assessment of rejection probability are scarce. In the multicenter (n = 7) prospective clinical cohort "ChilSFree" study, we aimed to characterize longitudinal dynamics of soluble and cellular immune mediators during the first year after pLT and identify early biomarkers associated with outcome.
Clinical Implications and Molecular Features of Extracellular Matrix Networks in Soft Tissue Sarcomas
Authors: Valeriya Pankova, Lukas Krasny, William Kerrison, Yuen B. Tam, Madhumeeta Chadha, Jessica Burns, Christopher P. Wilding, Liang Chen, Avirup Chowdhury, Emma Perkins, Alexander T.J. Lee, Louise Howell, Nafia Guljar, Karen Sisley, Cyril Fisher, Priya Chudasama, Khin Thway, Robin L. Jones, Paul H. Huang
Journal: Clinical Cancer Research (2024)

The landscape of extracellular matrix (ECM) alterations in soft tissue sarcomas (STS) remains poorly characterized. We aimed to investigate the tumor ECM and adhesion signaling networks present in STS and their clinical implications. Proteomic and clinical data from 321 patients across 11 histological subtypes were analyzed to define ECM and integrin adhesion networks. Subgroup analysis was performed in leiomyosarcomas (LMS), dedifferentiated liposarcomas (DDLPS), and undifferentiated pleomorphic sarcomas (UPS). This analysis defined subtype-specific ECM profiles including enrichment of basement membrane proteins in LMS and ECM proteases in UPS. Across the cohort, we identified three distinct coregulated ECM networks which are associated with tumor malignancy grade and histological subtype. Comparative analysis of LMS cell line and patient proteomic data identified the lymphocyte cytosolic protein 1 cytoskeletal protein as a prognostic factor in LMS. Characterization of ECM network events in DDLPS revealed three subtypes with distinct oncogenic signaling pathways and survival outcomes. Evaluation of the DDLPS subtype with the poorest prognosis nominates ECM remodeling proteins as candidate antistromal therapeutic targets. Finally, we define a proteoglycan signature that is an independent prognostic factor for overall survival in DDLPS and UPS. STS comprise heterogeneous ECM signaling networks and matrix-specific features that have utility for risk stratification and therapy selection, which could in future guide precision medicine in these rare cancers.
Uncovering Subclinical Atherosclerosis: Assessment of Low-Attenuation Plaques in Low Risk Group
Authors: Muhammed I. Erbay, Shriraj Susarla, Duo Lee, Leili Pourafkari, April Kinninger, Marziyeh Bagheri, Hossein Hamidi, Muneeb A. Khan, Rachelle N. Bishay, Matthew J. Budoff
Journal: JACC. Cardiovascular imaging (2024)