tbuckley/cabot-search huggingface dataset:
Fish Allergenicity Ladder and Parvalbumin Epitopes for Predicting Clinical Cross‐Reactivity and Reintroduction in Chinese Population
Authors: Christine Y. Y. Wai, Nicki Y. H. Leung, Agnes S. Y. Leung, Man Fung Tang, Åsa Marknell DeWitt, Jaime S. Rosa Duque, Gilbert T. Chua, Yat Sun Yau, Wai Hung Chan, Po Ki Ho, Mike Y. W. Kwan, Qun Ui Lee, Joshua S. C. Wong, Ivan C. S. Lam, James W. C. H. Cheng, David C. K. Luk, Zhongyi Liu, Noelle Anne Ngai, Oi Man Chan, Patrick S. C. Leung, Gary W. K. Wong, Ting Fan Leung
Journal: Allergy (2025)

ABSTRACT Background IgE‐mediated fish allergy has long been considered an umbrella term due to the high cross‐reactivity of parvalbumin, the major fish allergen. Yet, clinical tolerance to certain fish highlights allergenicity differences. In this study, we sought to construct a fish allergenicity ladder and identify fish parvalbumin epitopes to improve the diagnosis of fish allergy. Methods Reported clinical history and the serum‐specific IgE (sIgE) responses of 200 Chinese subjects with suspected fish allergy were collected and analyzed, while the relative parvalbumin content in different fish was measured for the construction of a fish allergenicity ladder. Double‐blind placebo‐controlled food challenge (DBPCFC) and open challenge against salmon, grass carp, and grouper were performed in 58 selected patients for validation of the ladder. Epitope mapping was performed by peptide array against parvalbumins of salmon (both β‐1 and β‐2), cod, grouper, and grass carp with sera from fish allergic ( n = 11), partial fish tolerant ( n = 12), and complete fish tolerant ( n = 5) patients diagnosed based on oral food challenge outcome. Results The distribution pattern of reported history of fish allergy and tolerance, sIgE and molecular data, as well as their strong positive correlation led to the construction of a 3‐step fish allergenicity ladder comprising: step 1 of the least allergenic fishes (tuna, halibut, salmon and cod), steps 2 of moderately allergenic fishes (herring and grouper) to step 3 of highly allergenic fishes (catfish, grass carp and tilapia). Epitope mapping revealed one epitope from grouper parvalbumin (AA64‐78) for diagnosing general fish allergy and one epitopic region from salmon parvalbumin (AA19‐33) as a biomarker of specific fish tolerance. Only epitope‐specific IgE differentiated these patients but not sIgE to fish extract or parvalbumin. Conclusion The fish ladder and epitopes discovery can precisely differentiate fish‐allergic and tolerant subjects and guide fish reintroduction by stepping up the ladder, which innovates fish allergy care in the next millennium.
Bimekizumab durability of efficacy through 196 weeks and safety through 4 years in patients with moderate to severe plaque psoriasis: Results from the BE BRIGHT open-label extension trial
Authors: Andrew Blauvelt, Richard G Langley, Mark Lebwohl, Bruce Strober, Richard B Warren, Luis Puig, Akimichi Morita, Kenneth B Gordon, Pablo Fernandez-Peñas, Sarah Kavanagh, José M López Pinto, Jérémy Lambert, Bengt Hoepken, Delphine Deherder, Nancy Cross, Diamant Thaçi
Journal: Journal of the American Academy of Dermatology (2025)
Effectiveness and safety of ruxolitinib cream in Chinese patients with nonsegmental vitiligo
Authors: He Huang, Yujun Sheng, Min Li, Xianfa Tang, Yaohua Zhang, Dawei Duan, Hequn Huang, Jurui Zhang, Weiran Li, Tingting Zhu, Huayang Tang, Yuanyuan Yin, Leihong Xiang, Xuejun Zhang, Youwen Zhou, Yong Cui, Bo Zhang
Journal: Journal of the American Academy of Dermatology (2025)
Arginine Therapy for Pain in Sickle Cell Disease: A Phase‐2 Randomized, Placebo‐Controlled Trial
Authors: Claudia R. Morris, Dunia Hatabah, Rawan Korman, Scott Gillespie, Nitya Bakshi, Lou Ann Brown, Frank Harris, Deborah Leake, Chris A. Rees, Kirshma Khemani, Elliott P. Vichinsky, Alexus Locke, Bridget Wynn, Mark A. Griffiths, Hagar Wilkinson, Polly Kumari, Lisa Sudmeier, Sruti Shiva, Carlton D. Dampier
Journal: American Journal of Hematology (2025)

ABSTRACT We present a prospective randomized, placebo‐controlled trial of intravenous arginine in patients 3–21 years hospitalized with sickle cell disease vaso‐occlusive pain episodes (SCD‐VOE) at two tertiary‐care children's hospitals. Participants were randomized into 1 of 3 arms: Standard‐dose (SD; 100 mg/kg/dose) every 8 h, Loading‐dose (200 mg/kg followed by SD), or Placebo . The primary outcome was total parenteral opioid use (TPO). Secondary outcomes included time‐to‐crisis‐resolution, pain scores, patient‐reported outcomes (PROs), arginine bioavailability, and biomarkers of oxidative stress/mitochondrial function. Of 1548 patients screened, 108 were randomized (36 per study‐arm; mean 12.6 ± 3.8 years, 52% female, and 65% hemoglobin‐SS). This study did not meet its primary endpoint. TPO, time‐to‐crisis‐resolution, pain scores, and PROs at discharge were similar across arms. Post hoc sensitivity analyses of children 5–16 years old demonstrated nearly double TPO utilization in those receiving placebo versus arginine ( n = 87, p = 0.056), achieving significance in patients with plasma arginine &lt; 60 μM. Arginine was low at presentation in 79% of patients (mean 50 ± 28 μM), and increased with arginine therapy ( p &lt; 0.001). Arginine bioavailability at VOE presentation inversely correlated with time‐to‐crisis‐resolution ( r = −0.39, p = 0.01) after placebo, an association eliminated by arginine supplementation ( r = −0.04, p = 0.70). A dose‐dependent increase in platelet‐mitochondrial activity occurred after arginine versus no change after placebo ( p &lt; 0.001); plasma protein‐carbonyl levels, a measure of oxidative stress, decreased after arginine therapy ( p &lt; 0.001) but increased in the placebo group ( p = 0.02). SCD‐VOE is associated with an acquired arginine deficiency that correlates with worse clinical outcomes. Arginine improved mitochondrial function and decreased oxidative stress compared to placebo, with clinically relevant opioid‐sparing becoming significant in children with the lowest arginine concentration. Trial Registration Registered with ClinicalTrials.gov (NCT02536170) in August 2015
Method of Reducing Radiation Exposure to the Physician during X-ray Endovascular Embolization of Uterine Arteries
Authors: B. M. Sharafutdinov, S. A. Ryzhkin, A. A. Bagaviev, R. S. Mirvaliev
Journal: Radiology - Practice (2025)

Objective. Every day in order to reduce the risk of complications and for early activation of the patient, interest in minimally invasive surgery is growing. One of these areas is X-ray endovascular surgery. It’s quite universal and high-effective, safe and low-traumatic. However, daily work in X-ray conditions is associated with the risk of occupational pathology among medical workers. Accordingly, we proposed a method of special patient positioning to reduce the radiation dose to medical staff. The choice of access is important for transcatheter interventions, in particular uterine artery embolization (UAE). Currently, transradial access is considered preferable, characterized by a low risk of vascular complications compared to traditional transfemoral access and allowing to reduce procedure time and radiation exposure for healthcare workers and patients. Materials and methods. A prospective analysis of 20 patients was conducted at the Medical Unit of the Kazan Federal University. The patients were randomized into 2 groups: 10 patients underwent UAE via transradial access with standard positioning and 10 patients positioning the lower extremities to the C-arm of the angiographic complex. Indications for UAE were uterine fibroids with clinical manifestations. The patients underwent selective bilateral step-by-step catheterization and angiography of the uterine arteries in a direct projection without C-arm angulation in the DSA Body 4 CARE mode, followed by alternate embolization with 500–900 μm microspheres until stasis of the contrast agent was achieved in distal segments of uterine arteries. During radiation monitoring in the X-ray room procedure room, measurements were carried out using a highly sensitive compact X-ray and gamma radiation dosimeter DKS-AT 1123 at the surgeon’s workplace at 4 main points. Results. In standard laying the average equivalent dose rate (EDR) value in the operating room of the doctor-operator during radiography was: min EDR 1.881 μSv/h, max EDR — 3.998 μSv/h, during fluoroscopy: min EDR — 0.518 μSv/h, max EDR — 1.088 μSv/h. When laying with lower limbs to the C-arc, the average EDR value in the operating room of the operating physician during radiography was: min EDR — 0.293 μSv/h, max EDR — 0.745 μSv/h, during fluoroscopy: min EDR of the personnel — 0.143 μSv/h, max EDR of the personnel — 0.257 μSv/h. Conclusion. Using a fundamentally new installation method, it was possible to significantly reduce the radiation dose to the operator, thereby minimizing the risks of professional pathologies of interventional radiologists.
X-ray Diagnostics of Degenerative Spinal Canal Stenosis at the Cervical Level (Literature Review)
Authors: V. S. Petrova, P. V. Seliverstov, V. A. Sorokovikov, S. N. Larionov
Journal: Radiology - Practice (2025)

Objective . To highlight the history of development and the current state of radiation diagnostics for spinal canal stenosis at the cervical level based on the analysis of domestic and foreign publications published in open access databases. Materials and Methods . The search and selection of publications was carried out on the basis of the online resources eLibrary and PubMed in the period from 2019 to 2024. Results . The presented literature review analyzes publications with research data on the morphometric characteristics of spinal canal stenosis, the causes of stenosis, its complications and clinical manifestations, the biochemistry of the degeneration process, and etiopathogenetic characteristics depending on the innate features of the spinal canal. Conclusion . Despite a sufficient number of publications, there is no unified approach to the method of quantitative assessment of the degree of stenosis. Imaging diagnostic methods should be used in various combinations, complementing the information obtained to select the optimal treatment method
Stratification of the Oncological Risk of Thyroid Nodules: Historical Background and the Current State of the Issue
Authors: A. D. Zubov, O. V. Senchenko
Journal: Radiology - Practice (2025)

Objective. Evaluation of existing approaches to cancer risk stratification of thyroid nodules based on ultrasound data. Materials and Methods. The study of literature data in the historical aspect, modern scientific publications, specialized clinical protocols and consensuses. Results. Currently, there are many scales that are similar or close in name, but differ fundamentally in the methods of evaluation («ultrasound models», algorithms, number of cancer signs, scores, etc.), the number and value of categories and subcategories, and the recommendations made. The most famous among them are: TIRADS – E. Horvath et al. (Chile, 2009), which includes 6 categories, including 2 subcategories; THIRADS – A. D. Zubov et al. (currently in Russia, 2010): 5 categories, including 2 subcategories; TIRADS – Jin Kwak et al. (Republic of Korea, 2011): 5 categories, including 3 subcategories; TIRADS – G. Russ et al. (France, 2011): 7 categories, including 3 subcategories; ACR TI-RADS – (USA, 2017): 5 categories; EU-TIRADS (international group, 2017): 5 categories; TI-RADS (Russia, 2020): 6 categories. It has been established that at the present stage, clinicians (oncologists, endocrinologists) do not have sufficient information about the diversity of existing stratification scales. This has led to ambiguity of wording and incorrect references in current clinical recommendations and other regulatory documents defining the use of a particular stratification scale. Practitioners doctors of ultrasound diagnostics in the vast majority of cases do not indicate or incorrectly indicate the stratification scale used. Since the same figure in different scales may indicate clinically different situations, missing, incorrect or ambiguous indication may lead to errors in cancer risk assessment and patient management. Conclusion. Thus, unification and standardization of the used stratification scales is necessary to ensure mutual understanding of specialists and to exclude different interpretations of ultrasound conclusions. The obligation to use a single scale at all stages of the treatment and diagnostic process by all specialists in all regions, and the indication of which one, should be correctly and unambiguously defined in all relevant regulatory documents.
Ultrasound Support of Peritoneal Dialysis in Children
Authors: E. B. Olkhova, A. L. Muzurov, M. M. Fedoseeva, V. O. Soboleva
Journal: Radiology - Practice (2025)

Background . Treatment of patients with acute kidney injury and chronic kidney disease requires renal replacement therapy, peritoneal dialysis (PD) is one of the methods. Objective . Study of ultrasound capabilities in visualization of PD complications in children. Materials and Methods. Over the last 10 years in the Department of Gravitational Blood Surgery and Hemodialysis of St. Vladimir's Hospital in Moscow, about 605 patients with acute kidney injury and chronic kidney disease aged from 1 month to 17 years 11 months receiving PD treatment were observed, half of them had complaints associated with PD and requiring echographic differential diagnosis. Ultrasound was performed on Acuson/Sequoia 512, Voluson E-8, Voluson E-10, Acuson NX3. Results . The variants of peritoneal catheter (PC) visualization in normal and obstructed conditions were studied: omentum fragments, fat suspensions of the colon and uterine appendages fragments (fimbriae) were visualized as irregularly shaped echogenic inclusions inside the catheter. Dialysis peritonitis in the debut of the disease at ultrasound looked like a finely dispersed suspension in the dialysate, later there was organization of dialysate with the formation of a grid of organized fluid. The possibilities of echographic diagnosis of intestinal obstruction due to PD are analyzed, rare cases of visualization of encapsulating peritoneal fibrosis in children are presented. The possibilities of ultrasound in the assessment of scrotal complications of PD in infants, variants of visualization of ventral hernias are shown. Such rare complications of PD in children as tunnel and hemorrhagic complications are presented. Conclusion Abdominal ultrasound with targeted PC's imaging should be performed on a patient on PD immediately if any abdominal pathology is Changes in the consistency of dialysate on ultrasound in PD allow us to judge the dynamics of the disease and predict the prospects of resumption of PC disruption and dislocation in children can be accurately assessed echographically Intestinal obstruction in children on PD, may be due to PC position, but it is rarely possible to visualize this on In the vast majority of cases, nonspecific changes typical of low bowel obstruction are visualized. If children have hernias provoked by PD, ultrasound can reliably assess the size of the hernia’s sac or dialysate accumulation, visualize the size of the hernia gate and differentiate hernial
Features of Computed Tomography of the Head and Neck Area in Oncological Practice
Authors: V. A. Nechaev, A. V. Golovyakhina, Е. A. Kulikova, S. A. Kravtsov
Journal: Radiology - Practice (2025)

Objective. To demonstrate different approaches to head and neck computed tomography in cancer patients depending on the presumed or established diagnosis. Materials and Methods. A search was conducted for scientific publications and information- analytical systems PubMed, eLibrary, Google Scholar by key words: CT head and neck protocol, CT dynamic maneuver, CT head and neck protocol contrast administration, CT head and neck scanning protocol. Results. On the basis of the data of the scientific literature analysis and our own experience the peculiarities of contrast administration during CT of the head and neck region in oncologic practice with the use of monoand biphasic scanning protocols, as well as the patient's performance of additional commands during the study are presented. Conclusion. Despite the standardization of computed tomography, there are different approaches to the CT head and neck protocol in the form of monophasic and biphasic contrasting, as well as the use of various functional tests by the patient. To improve visualization and adequate assessment of the tumor process, it is advisable to apply in practice CT with additional functional tests during scanning depending on the presumed or established diagnosis.
DEAD‐Box Helicase 6 Blockade in Brain‐Derived Aβ Oligomers From Alzheimer's Disease Patients Attenuates Neurotoxicity
Authors: Xiaoxu Wang, Lu Dai, Na Wu, Donghui Wu, Xinyuan Wang, Xia Meng, Qilei Zhang, Jing Lu, Xiaoxin Yan, Jing Zhang, Baian Chen
Journal: MedComm (2025)

ABSTRACT There are no effective curative treatments for Alzheimer's disease (AD), the most prevalent form of dementia. Amyloid‐beta (Aβ) oligomers are considered key neurotoxic molecules that trigger AD. Recent studies have shown that direct antibody targeting of Aβ oligomers is beneficial for early AD patients; however, serious side effects (e.g., brain hemorrhage, edema, and shrinkage) persist. Considering that Aβ oligomers readily bind to other proteins, contributing to neurotoxicity and AD onset, those proteins could represent alternative therapeutic targets. However, proteins that bind to Aβ oligomers in the brains of AD patients have not yet been identified. In this study, we identified four proteins (DDX6, DSP, JUP, and HRNR) that bind to Aβ oligomers derived from the brains of AD patients. Intriguingly, among these four proteins, only the blockade of DEAD‐box helicase 6 (DDX6) in human‐derived Aβ oligomers attenuated their neurotoxicity both in vitro and in vivo. Mechanistic analysis revealed that DDX6 promotes the formation of Aβ oligomers, likely due to DDX6 bind to Aβ oligomers at four distinct sites. These findings suggest that DDX6 could serve as a potential therapeutic target to reduce the neurotoxicity of Aβ oligomers in the brain and prevent the progression of AD.
Self‐Healing Hydrogels: Mechanisms and Biomedical Applications
Authors: Lingling Xue, Ran An, Junqi Zhao, Mengdi Qiu, Zhongxia Wang, Haozhen Ren, Decai Yu, Xinhua Zhu
Journal: MedComm (2025)

ABSTRACT Hydrogels have emerged as dependable candidates for tissue repair because of their exceptional biocompatibility and tunable mechanical properties. However, conventional hydrogels are vulnerable to damage owing to mechanical stress and environmental factors that compromise their structural integrity and reduce their lifespan. In contrast, self‐healing hydrogels with their inherent ability to restore structure and function autonomously offer prolonged efficacy and enhanced appeal. These hydrogels can be engineered into innovative forms including stimulus‐responsive, self‐degradable, injectable, and drug‐loaded variants, thereby enhancing their applicability in wound healing, drug delivery, and tissue engineering. This review summarizes the categories and mechanisms of self‐healing hydrogels, along with their biomedical applications, including tissue repair, drug delivery, and biosensing. Tissue repair includes wound healing, bone‐related repair, nerve repair, and cardiac repair. Additionally, we explored the challenges that self‐healing hydrogels continue to face in tissue repair and presented a forward‐looking perspective on their development. Consequently, it is anticipated that self‐healing hydrogels will be progressively designed and developed for applications that extend beyond tissue repair to a broader range of biomedical applications.
Re: Vasu et al.: Risk of glaucoma in non-diabetic patients using a glucagon like peptide-1 receptor agonist (Ophthalmology. 2025 Feb 18:S0161-6420(25)00132-0)
Authors: Zuhair Zaidi, Ahmed Alshaikhsalama, Amer Alsoudi, Ehsan Rahimy
Journal: Ophthalmology (2025)
Abstract LB464: Identification of endothelial Ovol1 as a novel regulator of Slug-dependent angiogenic signaling in colorectal cancer
Authors: Kapil Thapa, Brandon Burow, Emma Bates, Jennifer Fang
Journal: Cancer Research (2025)

Abstract Cancer progression and metastasis depends upon tumor neovascularization to connect solid tumors to the systemic circulation. Endothelial cells that line the inner lumen of blood vessels critically support the pathological angiogenesis needed to form tumor blood vessels, and anti-angiogenics are frequently used as part of chemotherapy treatment for many cancer types. However, anti-angiogenics are often less effective than expected such as in colorectal cancer where the VEGF inhibitor bevacizumab improves outcomes in only a subset of patients. This suggests that new strategies targeting core angiogenic pathways may be more promising. We recently found that transcription factor Slug mediates a partial endothelial-to-mesenchymal transition (pEndoMT) in endothelial cells that is essential for sprouting angiogenesis and tumor neovascularization. However, an outstanding question remains: what regulates Slug during tumor angiogenesis? Sequence analysis of the Slug gene reveals two predicted DNA-binding sites for the transcription factor Ovol1. Here, we explore the hypothesis that Ovol1 regulates Slug to induce pEndoMT in angiogenesis. We show that Ovol1 is necessary and sufficient to drive angiogenesis in vitro in a Slug-dependent manner. Constitutive overexpression of Ovol1 increases Slug expression in cultured endothelial cells, and endothelial-specific Ovol1 knockout leads to suppression of colorectal cancer tumor xenograft growth in mice. In summary, we report that Ovol1 is a novel regulator of sprouting angiogenesis and tumor neovascularization via effects on Slug levels. This expanded understanding of Ovol-Slug regulation of the pEndoMT signaling axis in endothelial cells and in colorectal cancer is expected to help drive development of new and potentially more effective anti-angiogenic therapies that may one day help to better suppress tumor growth in cancer patients. (Funding: Louisiana Cancer Research Center New Investigator Award (CR1305A6), Louisiana Cancer Research Center Summer Undergraduate Cancer Research Experience Program, Tulane Carol Lavin Bernick Faculty Research Award, and Tulane Committee on Research Fellowship Award) Citation Format: Kapil Thapa, Brandon Burow, Emma Bates, Jennifer Fang. Identification of endothelial Ovol1 as a novel regulator of Slug-dependent angiogenic signaling in colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_2):Abstract nr LB464.