AB0983 PREVALENCE AND RELATIONSHIP OF PSEUDONORMAL DIASTOLIC FUNCTION WITH NOCTURNAL SLEEP IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: M. F. Elizondo-Benitez, A. L. Guajardo-Aldaco, J. R. Azpiri-Lopez, D. A. Galarza-Delgado, I. J. Colunga-Pedraza, J. A. Cardenas-de la Garza, R. I. Arvizu-Rivera, V. Gonzalez-Gonzalez
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Sleep disorders are common in patients with Systemic Lupus Erythematosus (SLE). Up to 80% of SLE patients have poor sleep quality, and the prevalence rate of sleep disorders is 55–81%. Patients with SLE have a higher risk of myocardial involvement, which can result in ventricular dysfunction. A shorter sleep duration has been identified as a risk factor for cardiovascular diseases and increased mortality. Pseudonormal diastolic function pattern is a compensatory state of progressive heart failure, often underdiagnosed and undervalued by clinicians. <h3>Objectives:</h3> To identify the prevalence of pseudonormal diastolic function and its association with hours of nocturnal sleep in patients with SLE. <h3>Methods:</h3> Cross-sectional, observational, and comparative study of women with SLE who met the 2019 ACR/EULAR classification criteria, over 18 years of age. Patients with a diagnosis of any overlapping syndrome, a history of major cardiovascular events (myocardial infarction, stroke, and heart failure), and pregnant individuals were excluded. The hours of sleep were defined through clinical history and were divided accordingly into two groups: less than 7 hours and more than 7 hours of nighttime sleep. A transthoracic echocardiogram was performed on all study patients by a board-certified cardiologist, blinded to clinical information. The pseudonormal diastolic function pattern was defined as mitral deceleration time &gt;120 ms, E/E &gt;6, and E: A between 0.8-2.1, according to the standards of the American Society of Echocardiography guidelines. The distribution between groups was evaluated with the Kolmogorov-Smirnov test. Comparisons were made with the Chi-square test or Fisher's exact test and Student's t-test or Mann-Whitney U test, as appropriate. A value of <i>p</i>&lt;0.05 was considered statistically significant. <h3>Results:</h3> Hundred and one women with SLE were included, the mean age was 35.7 ±12.5 years, and the median duration of the disease was 63.5 (20-120) months. The most prevalent cardiovascular risk factor was high blood pressure (38%). Patients with less than 7 hours of nighttime sleep had a higher prevalence of diastolic pseudonormal function compared to patients with more than 7 hours of nighttime sleep (77.7% vs 57.4%, <i>p= 0.02</i>) (Table 1). <h3>Conclusion:</h3> Patients with SLE and less than 7 hours of sleep have a higher prevalence of pseudonormal diastolic function, which is a diastolic pattern related to adverse cardiac outcomes (higher hospital admission rates like the diastolic restrictive pattern). Patients with SLE should be approached globally, emphasizing their sleep hygiene given the impact on patients' quality of life and cardiovascular health. <h3>REFERENCES:</h3> <b>NIL.</b> <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>