tbuckley/cabot-search huggingface dataset:
Impact of Clinical Information on Melanocytic Skin Lesion Pathology Diagnosis
Authors: Belinda Lai, H. Peter Soyer, Lin Zhu, Peter M. Ferguson, Blake O’Brien, Tristan Dodds, Richard A. Scolyer, Gerardo Ferrara, Giuseppe Argenziano, Katy J. L. Bell
Journal: JAMA Dermatology (2024)

Importance There is poor accuracy and reproducibility for the histopathologic diagnosis of melanocytic skin lesions, and the provision of clinical information may improve this. Objective To examine the impact of clinical information on the histopathologic diagnosis of melanocytic skin lesions. Evidence Review PubMed, Embase, and Cochrane Library were searched for new records published from January 2018 to January 2024. References included in the 2018 Cancer Council Australia evidence review were also screened, and forward and backward citation searches were conducted. Findings From 2224 records screened, 162 full-text studies were assessed, and 7 studies were included. Studies included pathologists from Austria, Germany, the US, Italy, the UK, and Australia. Patient populations had a mean age of 43 to 55 years and a proportion of female participants of 23% to 63%. The risk of bias assessment demonstrated that all studies had domains at unclear or high risk of bias. Clinical images increased diagnostic certainty (3 studies) and agreement between pathologists (2 studies) led to diagnostic upgrades in 7.6% to 16.7% of interpretations. Clinical diagnosis on the pathology requisition form reduced the odds of missing a melanoma with progression (1 study), while more clinical elements on the form correlated with higher re-excision rates (1 study). Among patients with distant metastases on long-term follow-up, a prior consensus diagnosis of melanoma was established on histopathology alone. Conclusions and Relevance Providing clinical information to pathologists may improve diagnostic confidence and interobserver agreement and result in upgrading of the histopathologic diagnosis. While providing the clinical diagnosis may prevent missing a progressive melanoma, more research is needed to determine the appropriateness of histopathology upgrading when clinical images are provided and the impacts on patient outcomes.
Low-Dose Naltrexone Use in Biopsy-Proven Lichen Planus of the Nails
Authors: Eric R. Bray, Brian W. Morrison
Journal: JAMA Dermatology (2024)

Importance Nail lichen planus has the potential to cause permanent destruction of the nail unit and remains challenging to treat. Studies suggest that low-dose naltrexone is a safe and potentially effective treatment for other dermatologic conditions, including lichen planopilaris. Objective To assess the effectiveness of low-dose naltrexone in treating nail lichen planus. Design, Setting, and Participants This case series evaluates 7 adult patients with biopsy-proven nail lichen planus who were treated with low-dose naltrexone (3 mg per day) at the University of Miami dermatologic clinics from November 2022 to December 2023. The data were analyzed in March 2024. Patients were treated for at least 2 months and had in-person follow-up evaluation while receiving treatment. Main Outcomes and Measures The main outcome was posttreatment clinical nail lichen planus severity index, which was scored as clear, mild, moderate, or severe. Patients were evaluated for oral and cutaneous disease during the course of treatment. Tolerance and adverse events were noted. Results A total of 7 patients (mean [range] age, 60 [38-77] years; 3 female individuals) were included. All but 1 patient had been previously treated and did not respond to at least 1 prior treatment (median [range], 2.5 [0-4.0] treatments). Treatment duration ranged from 2 to 11 months. Clinical response was observed in 4 of 7 patients, with an overall 35% reduction in nail lichen planus severity index. Two patients with severe disease achieved a reduction to mild severity. None of the patients had to discontinue low-dose naltrexone due to adverse events, and no adverse events were reported. Conclusions and Relevance The results of this study suggest that low-dose naltrexone may be a therapeutic approach for treating nail lichen planus. Further controlled studies are warranted to better understand its clinical efficacy and safety profile in treating nail lichen planus.
Gastrointestinal Angiodysplasia Resolution After Transcatheter Aortic Valve Implantation
Authors: Lia C. M. J. Goltstein, Maxim J. P. Rooijakkers, Naomi D. E. Thierens, Selene C. M. Schoormans, Antonius E. van Herwaarden, Hanneke Beaumont, Charles Houdeville, Marlijn P. A. Hoeks, Erwin-Jan M. van Geenen, Sanna R. Rijpma, Xavier Dray, Niels van Royen, Joost P. H. Drenth
Journal: JAMA Network Open (2024)

Heyde syndrome is the cooccurrence of aortic stenosis and gastrointestinal bleeding secondary to vascular lesions, including angiodysplasias. Several studies have demonstrated cessation of gastrointestinal bleeding after transcatheter aortic valve implantation (TAVI), but the etiology and effects on vascular lesions are largely unknown.
New Statistical Editor—September 2024
Authors: Melina R. Kibbe
Journal: JAMA Surgery (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Autism Diagnosis Among US Children and Adults, 2011-2022
Authors: Luke P. Grosvenor, Lisa A. Croen, Frances L. Lynch, Ben J. Marafino, Melissa Maye, Robert B. Penfold, Gregory E. Simon, Jennifer L. Ames
Journal: JAMA Network Open (2024)

An improved understanding of autism spectrum disorder (ASD) prevalence over time and across the lifespan can inform health care service delivery for the growing population of autistic children and adults.
Cardiovascular Risks With SGLT2 Inhibitors in Clinical Practice Among Patients With Type 2 Diabetes
Authors: Hsuan-Yu Su, Chen-Yi Yang, Yu-Hsuan Lee, Pei-Fang Su, Yi-Chia Liu, Huang-Tz Ou
Journal: JAMA Network Open (2024)

Cardiovascular disease (CVD) can be recurrent during type 2 diabetes (T2D) progression in this aging population. The effectiveness of sodium-glucose cotransporter 2 inhibitor (SGLT2i) therapy on total (ie, first and subsequent) CVD among patients with T2D in clinical practice remains uncertain.
A Virtual Breakthrough Series Collaborative for Missed Test Results
Authors: Lisa Zubkoff, Andrew J. Zimolzak, Ashley N. D. Meyer, Jennifer Sloane, Umber Shahid, Traber Giardina, Sahar A. Memon, Taylor M. Scott, Daniel R. Murphy, Hardeep Singh
Journal: JAMA Network Open (2024)

Missed test results, defined as test results not followed up within an appropriate time frame, are common and lead to delays in diagnosis and treatment.
Successful Treatment of Recalcitrant Chloracne With Adalimumab in an Older Man
Authors: Poonam Saini, Nitish Kumar, Naveen Kumar Kansal, Ashok Singh, Elumalai Gnanamani, Naveen Kumar, Riti Bhatia
Journal: JAMA Dermatology (2024)

This case report describes a man in his 60s with recalcitrant chloracne caused by chlorantraniliprole, a chlorinated pesticide, exposure successfully treated with adalimumab.
Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment
Authors: Yuto Uchida, Kei Nishimaki, Anja Soldan, Abhay Moghekar, Marilyn Albert, Kenichi Oishi
Journal: JAMA Network Open (2024)

It remains unclear which risk factors accelerate brain atrophy along with a progression from normal cognition to mild cognitive impairment (MCI).
Validation of the Kansas City Cardiomyopathy Questionnaire in Patients With Tricuspid Regurgitation
Authors: Suzanne V. Arnold, John A. Spertus, Kensey Gosch, Shannon M. Dunlay, Danielle M. Olds, Philip G. Jones, Fraser D. Bocell, Changfu Wu, David J. Cohen
Journal: JAMA Cardiology (2024)

Improving patients' health status is a key goal of treating tricuspid regurgitation (TR). The Kansas City Cardiomyopathy Questionnaire (KCCQ) is a heart failure disease-specific health status measure used to capture the health status impact of TR and the benefit of transcatheter tricuspid valve intervention (TTVI), but its validity in this clinical setting is unknown.
Type I MET inhibitors cooperate with PD-1 blockade to promote rejection of hepatocellular carcinoma
Authors: Ricardo DeAzevedo, Madeline Steiner, Broderick X Turner, Arthur Liu, Sherwin Newton, Joanna Schmidt, Rachel Fleming, Angelica Tolentino, Ahmed O Kaseb, Michael A Curran
Journal: Journal for ImmunoTherapy of Cancer (2024)

Blockade of the immune checkpoints programmed death-1 (PD-1) and cytotoxic lymphocyte antigen 4 has improved outcomes for patients with hepatocellular carcinoma (HCC), yet most still fail to achieve objective clinical benefit. MET plays key roles in both HCC tumorigenesis and immunosuppressive conditioning; however, inhibition of MET causes upregulation of PD-ligand 1 (PD-L1) suggesting the use of these inhibitors in the context of PD-1 blockade. We sought to investigate across the Hepa1-6, HCA-1 and diethylnitrosamine (DEN) models of HCC whether the combination of more specific type I versus more pleiotropic type II MET inhibitors would confer superior outcomes in combination with PD-1 blockade. While MET inhibition demonstrated cooperativity with αPD-1 across all three models, the type I MET inhibitor capmatinib showed optimal activity in combination and statistically significantly outperformed the combination with the type II inhibitor cabozantinib in the αPD-1 refractory DEN model. In both HCA-1 and DEN HCC, the capmatinib and αPD-1 combination enhanced CD8 T cell frequency and activation state while limiting intratumoral myeloid immune suppression. In vitro studies of antigen-specific T cell activation reveal significantly less inhibition of effector cytokine production and proliferation by capmatinib versus by type II or type III MET inhibitors. These findings suggest significant potential for clinical HCC combination studies of type I MET inhibitors and PD-1 blockade where prior trials using type II inhibitors have yielded limited benefit.
Maternal-Newborn ABO Blood Groups and Risk of Bacterial Infection in Newborns
Authors: Emily Ana Butler, Joel G. Ray, Eyal Cohen
Journal: JAMA Network Open (2024)

Newborn immunity largely relies on maternal-fetal transfer of antibodies in utero. Incongruency in ABO blood groups between a mother and newborn may be associated with protection against serious infections, but data specific to newborn bacterial infections are lacking.
Resting Heart Rate and Incident Atrial Fibrillation in Black Adults in the Jackson Heart Study
Authors: Vidhushei Yogeswaran, Kerri L. Wiggins, Colleen M. Sitlani, Leonard Ilkhanoff, Emelia J. Benjamin, Susan R. Heckbert, Wondwosen Kassahun-Yimer, James S. Floyd
Journal: JAMA Network Open (2024)

Importance Resting heart rate (RHR) is a widely available measure of cardiovascular fitness that has been associated with several cardiovascular outcomes. RHR has previously been associated with the risk of atrial fibrillation (AF) among individuals of European ancestry, but little is known about this association in Black adults. Objective To evaluate the association between RHR and incident AF in a large community-based sample of Black adults, independently of established risk factors. Design, Setting, and Participants This cohort study uses data from the Jackson Heart Study, a prospective community-based cohort in Jackson, Mississippi. Participants without prevalent AF were included and were monitored for new-onset AF during follow-up, from 2000 through 2016. Data analysis was performed from August 1 to December 11, 2023. Exposure RHR was assessed from resting 12-lead electrocardiograms performed at examination 1 (2000-2004) and examination 3 (2009-2013). Main Outcomes and Measures AF was identified from study electrocardiograms, hospitalization discharge diagnosis codes, and Medicare claims diagnosis codes. Cox regression was used to evaluate the association between baseline (examination 1) RHR and incident AF, adjusting for established AF risk factors. Results Among 4965 Black adults eligible for analysis, the mean (SD) age was 55 (13) years, 1830 (37%) were male, and the mean (SD) RHR at baseline was 65 (11) beats per minute (bpm). During a median (IQR) 14 (12-15) years of follow-up, there were 458 incident AF events, resulting in an incident rate of 7.5 per 1000 person-years (95% CI, 6.8-8.2 incidents per 1000 person-years). Each 10-bpm higher RHR was associated with a 9% higher risk of incident AF after adjustment for AF risk factors (hazard ratio, 1.09; 95% CI, 1.00-1.19). In a sensitivity analysis that excluded individuals with prior heart failure, prior myocardial infarction, and antiarrhythmic medication use at baseline, the hazard ratio was 1.14 (95% CI, 1.02-1.28). There was little evidence of effect modification of these associations by age, sex, body mass index, hypertension, or physical activity level. Conclusions and Relevance In this large prospective cohort study of Black adults, elevated baseline RHR was associated with increased risk of incident AF, consistent with findings from previous studies of European ancestry populations. Future research should focus on determining whether RHR can be used to screen patients at high risk of AF.
Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans
Authors: Ian C. Fischer, Peter J. Na, Sheila T. Nagamatsu, Dilip V. Jeste, Brenda Cabrera-Mendoza, Janitza L. Montalvo-Ortiz, John H. Krystal, Renato Polimanti, Joel Gelernter, Robert H. Pietrzak
Journal: JAMA Psychiatry (2024)

This cross-sectional study uses data from 1135 male, European-American US military veterans to assess whether risk and protective factors influenced associations between posttraumatic stress disorder and epigenetic age.
Optimizing Strategies to Prevent Cognitive Decline With 20-Year Brain Imaging
Authors: Shohei Fujita
Journal: JAMA Network Open (2024)

Yuto Uchida, MD, PhD; Kei Nishimaki; Anja Soldan, PhD; Abhay Moghekar, MBBS; Marilyn Albert, PhD; Kenichi Oishi, MD, PhD
Measuring Health Status in Patients With Tricuspid Regurgitation
Authors: Eldrin F. Lewis
Journal: JAMA Cardiology (2024)

Suzanne V. Arnold, MD, MHA; John A. Spertus, MD, MPH; Kensey Gosch, MS; Shannon M. Dunlay, MD, MS; Danielle M. Olds, RN, PhD; Philip G. Jones, MS; Fraser D. Bocell, PhD; Changfu Wu, PhD; David J. Cohen, MD, MSc
Penile Persistent Yellow Plaques With Recurrent Ulcerations
Authors: Laura Parra-Navarro, Ramon M. Pujol, Gemma Martín-Ezquerra
Journal: JAMA Dermatology (2024)

A man in his 30s presented with a painful ulcer on the ventral aspect of the penile shaft that had appeared 3 months before. Physical examination disclosed discrete penile swelling with an indurated yellowish plaque diffusely involving the ventral surface. What is your diagnosis?
Community and Patient Features and Health Care Point of Entry for Pediatric Concussion
Authors: Daniel J. Corwin, Daniele Fedonni, Catherine C. McDonald, Alexis Peterson, Juliet Haarbauer-Krupa, Melissa Godfrey, Peter Camacho, Tyra Bryant-Stephens, Christina L. Master, Kristy B. Arbogast
Journal: JAMA Network Open (2024)

Many recent advances in pediatric concussion care are implemented by specialists; however, children with concussion receive care across varied locations. Thus, it is critical to identify which children have access to the most up-to-date treatment strategies.
Electroencephalography-Guided Anesthesia and Delirium in Older Adults—Reply
Authors: Alain Deschamps, Michael Avidan, Arbi Ben Abdallah
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Old Doc
Authors: Abigail Zuger
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electroencephalography-Guided Anesthesia and Delirium in Older Adults
Authors: Shuyang Xiang, Wangning ShangGuan, Xiaocou Wang
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
State Policies Regulating Law Enforcement Access to Prescription Drug Monitoring Program Testosterone Prescription Data
Authors: Katie McCreedy, Jule von der Heydt, Aanchalika Chauhan, Rajvi Shah, Sunyou Kang, Elizabeth Platt, Leo Beletsky
Journal: JAMA (2024)

This study identifies state policies authorizing law enforcement access to prescription drug monitoring program data and discusses the characteristics of those policies, particularly in states with laws banning gender-affirming care.
FDA Approval Summary: Olutasidenib for Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia with an Isocitrate Dehydrogenase-1 Mutation
Authors: Ashley C. Woods, Kelly J. Norsworthy, Moran Choe, Brenda J. Gehrke, Haiyan Chen, Jonathon Vallejo, Lili Pan, Xiling Jiang, Hongshan Li, Jeffrey Kraft, Jiang Liu, Rosane Charlab, Olanrewaju O. Okusanya, Brian Booth, Richard Pazdur, Marc R. Theoret, R. Angelo de Claro
Journal: Clinical Cancer Research (2024)

On December 1, 2022, the FDA approved the new molecular entity olutasidenib (Rezlidhia, Rigel Pharmaceuticals), a small-molecule inhibitor of isocitrate dehydrogenase 1, for the treatment of adult patients with relapsed or refractory acute myeloid leukemia with a susceptible isocitrate dehydrogenase 1 mutation as detected by an FDA-approved test. The efficacy of olutasidenib was established based on complete remission (CR) + CR with partial hematologic recovery (CRh) rate, duration of CR + CRh, and conversion of transfusion dependence to transfusion independence in Study 2102-HEM-101. In the pivotal trial, 147 adult patients treated with 150 mg twice daily of olutasidenib were evaluable for efficacy. With a median follow-up of 10.2 months, the CR/CRh rate was 35% (95% confidence interval, 27%-43%), with a median duration of response of 25.9 months [95% confidence interval, 13.5-not reached]. Of the 86 patients who were transfusion dependent at baseline, 29 became transfusion independent (34%). The most common (≥20%) adverse reactions were nausea, fatigue, arthralgia, leukocytosis, dyspnea, pyrexia, rash, mucositis, diarrhea, and transaminitis. An assessment of long-term safety of olutasidenib is a condition of this approval.
Spatially resolved subcellular protein–protein interactomics in drug-perturbed lung-cancer cultures and tissues
Authors: Shuangyi Cai, Thomas Hu, Abhijeet Venkataraman, Felix G Rivera Moctezuma, Efe Ozturk, Nicholas Zhang, Mingshuang Wang, Tatenda Zvidzai, Sandip Das, Adithya Pillai, Frank Schneider, Suresh S Ramalingam, You-Take Oh, Shi-Yong Sun, Ahmet F Coskun
Journal: Nature Biomedical Engineering (2024)