tbuckley/cabot-search huggingface dataset:
Finding the minimum number of retrieved lymph nodes and negative lymph nodes in gastric cancer surgery: a real-world study
Authors: Yingxue Liu, Changming Zhou, Lu Gan, Qiyang Zhang, Jinjia Chang, Xin Wang, Xu Wang, Midie Xu, Jie Chen, Weiqi Sheng, Fenglin Liu
Journal: International Journal of Surgery (2024)

Background: Lymph node retrieval deficiency can lead to understagement and postoperative cancer recurrence, it is crucial to establish the standard number of retrieved lymph nodes (rLNs) and negative lymph nodes (nLNs) for patients undergoing gastrectomy. Methods: Patients who has gastric adenocarcinoma and underwent either radical subtotal gastrectomy (RSG) or radical total gastrectomy (RTG) between 2000 and 2022 were retrospectively included. The authors utilized restricted cubic spline (RCS) analysis to determine the ideal threshold for rLNs and nLNs. Survival analysis was conducted using Kaplan–Meier (KM) curves, log-rank tests and forest plots. Propensity score matching (PSM) was utilized to balance parameters between two groups. The median follow-up time for this study was 3095 days. Results: Our study found that there are significant tumor characteristic differences between RSG and RTG. For patients with N0–N3a stage undergoing RSG, retrieving greater than or equal to 24 lymph nodes intraoperatively were associated with better prognosis both before and after PSM [overall survival (OS): P &lt;0.001, P =0.019]; whereas for N3b stage, at least 32 rLNs were required (OS: P =0.006, P =0.023). Similarly, for patients with N0–N3a stage undergoing RTG, retrieving greater than or equal to 27 lymph nodes intraoperatively were associated with better prognosis both before and after PSM (OS: P &lt;0.001, P =0.047); whereas for N3b stage, at least 34 rLNs were required (OS: P &lt;0.001, P =0.003). Additionally, for patients undergoing RSG, having greater than or equal to 21 nLNs (OS: P &lt;0.001, P =0.013), and for those undergoing RTG, having greater than or equal to 22 nLNs (OS: P &lt;0.001, P &lt;0.001), were also associated with better prognosis both before and after PSM. Conclusions: For patients receiving RSG, rLNs should reach 24 when lymph nodes are limited, and 32 when lymph node metastasis is more extensive, with a minimum number of nLNs ideally reaching 21. Similarly, for patients receiving RTG, rLNs should reach 27 when lymph nodes are limited, 34 when lymph node metastasis is more extensive, and a minimum number of nLNs ideally reaching 22.
Integration of GPT-4 into multimodal bioinformatics for surgical specimens
Authors: Siqi Fan, Yue Zheng, Xu Sun, Ailin Zhao, Yijun Wu
Journal: International Journal of Surgery (2024)

Fan, Siqi MBBS; Zheng, Yue MD; Sun, Xu MD; Zhao, Ailin MD; Wu, Yijun MD Author Information
A commentary on “Management of Traumatic Brain Injury in Africa: challenges and opportunities” (Int J Surg. 2024 Apr 4; Online ahead of print.)
Authors: Qiushun Zhang, Yongyi Zhang, Junchen Zhang
Journal: International Journal of Surgery (2024)

aSchool of Clinical Medicine, Jining Medical Uinversity, Jining 272067, Shandong, China bSchool of Pharmacy, Shandong Second Medical University, Weifang 261053, Shandong, China cDepartment of Neurosurgery, Affiliated hospital of Jining medical University, Jining 272029, Shandong, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Neurosurgery, Affiliated hospital of Jining medical University, Jining, China. E-mail address: [email protected] (J. Zhang). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Letter to the editor “Early identification of delayed wound healing in complex diabetic foot ulcers treated with a dermal regeneration template: a novel clinical target and its risk factors”
Authors: Hewen Guan, Yuankuan Jiang, Jingrong Lin
Journal: International Journal of Surgery (2024)

Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: First Affiliated Hospital of Dalian Medical University Dalian, --- 选择一项 --- CHINA. E-mail address: [email protected] (J. Lin). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0/
Harnessing the potential of large language models in medicine: opportunities, challenges, and ethical considerations
Authors: Zhaohui Zhou, Wenyi Gan, Jiarui Xie, Zeji Guo, Zhiling Zhang
Journal: International Journal of Surgery (2024)

Zhou, Zhaohui MD; Gan, Wenyi MD; Xie, Jiarui MD; Guo, Zeji MD; Zhang, Zhiling MD Author Information
Commentary on：Predictive value of NT-proBNP and hs-TnT for outcomes after pediatric congenital cardiac surgery
Authors: Xinlei Fu, Shilong Meng, Xiating Huang, Siwen Chen
Journal: International Journal of Surgery (2024)

aThe First Clinical Medical College of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China bThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China cXiamen Hospital of Traditional Chinese Medicine Affiliated to Beijing University of Chinese Medicine, Xiamen, Fujian, China Xinlei Fu and Shilong Meng contributed equally to this work and are the co-first authors. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Xiamen Hospital of Traditional Chinese Medicine Affiliated to Beijing University of Chinese Medicine, 1739 Xianyue Road ,Xiamen, Fujian, China, 361000. E-mail address: [email protected] (S. Chen). This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0/
Letter to the editor for the article “Comparative dose-response study on the infusion of norepinephrine combined with intravenous ondansetron versus placebo for preventing hypotension during spinal anesthesia for cesarean section: a randomised controlled trial”
Authors: Jiaan Lu, Hao Chi, Guanhu Yang, Qibiao Wu
Journal: International Journal of Surgery (2024)

aClinical Medical College, Southwest Medical University, Luzhou 646000, China bDepartment of Specialty Medicine, Ohio University, Athens 45701, OH, United States cFaculty of Chinese Medicine, and State Key Laboratory of Quality Research in Chinese Medicine, and University Hospital, Macau University of Science and Technology, Macau, Macao SAR, China Assistance with the study: none. Financial support and sponsorship: This work was supported by the Science and Technology Development Fund, Macau SAR (No.: 0098/2021/A2 and 0048/2023/AFJ), the National Natural Science Foundation of China (No.: 82361168663), and Macau University of Science and Technology's Faculty Research Grant (No: FRG-23-003-FC). Data availability statement: No data. Jiaan Lu, Hao Chi, Guanhu Yang These authors have contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Correspondence Auther: Faculty of Chinese Medicine, and State Key Laboratory of Quality Research in Chinese Medicine, and University Hospital, Macau University of Science and Technology, Macau, Macao SAR, China. [email protected](Q. Wu). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Unveiling New Frontiers: an innovative strategy offers insightful direction and motivation for postoperative lung injury prevention
Authors: Yu Wang, Shanglong Yao
Journal: International Journal of Surgery (2024)

aDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China bInstitute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China cKey Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China Yu Wang and Shanglong Yao equally contributed to the article. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan 430022, China; Phone: 86.13886128437. E-mail address: [email protected] (S. Yao). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0/
Long-term comparison of Image-guided thermal ablation vs. lobectomy for solitary papillary thyroid microcarcinoma: a multicenter retrospective cohort study
Authors: Lin Yan, WenHui Li, YaLin Zhu, Xinyang Li, Yingying Li, Yiming Li, Qing Song, Ying Che, Hui Wang, Yukun Luo
Journal: International Journal of Surgery (2024)

Image-guided thermal ablation has been applied in patients with papillary thyroid microcarcinoma (PTMC) who refuse surgery or active surveillance. However, evidence to support ablation is limited by single-center designs and a lack of long-term data. The purpose of this study was to compare long-term outcomes between ablation and lobectomy for patients with solitary PTMC.
Recent advances in stem cell therapy: efficacy, ethics, safety concerns, and future directions focusing on neurodegenerative disorders – a review
Authors: Rekha Khandia, Pankaj Gurjar, None Priyanka, Victoria Romashchenko, Sami A. Al-HUSSAIN, Magdi E. A. Zaki
Journal: International Journal of Surgery (2024)

Neurodegeneration refers to the gradual loss of neurons and extensive changes in glial cells like tau inclusions in astrocytes and oligodendrocytes, α-synuclein inclusions in oligodendrocytes and SOD1 aggregates in astrocytes along with deterioration in the motor, cognition, learning, and behavior. Common neurodegenerative disorders are Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), spinocerebellar ataxia (SCA), and supranuclear palsy. There is a lack of effective treatment for neurodegenerative diseases, and scientists are putting their efforts into developing therapies against them. Stem cell therapy has emerged as a hope for neurodegenerative disorders since it is not only the damaged neurons that might be replaced, but other neuromodulators and neuroprotectors are secreted. Stem cell terminal differentiation before implantation ensures the implantation of correct cells and molecular markers like carbonic anhydrase II, CNPase (2′,3′-cyclic nucleotide 3′-phosphohydrolase), myelin basic protein (MBP), and myelin oligodendrocyte glycoprotein (MOG) elucidate the differentiation. Secretion of various growth factors like epidermal growth factor (EGF), keratinocyte growth factor (KGF), vascular endothelial growth factor-α (VEGF-α), transforming growth factor (TGF), and macrophage inflammatory protein (MIP) supports cell survival, cell proliferation, blood vessel formation, axon regeneration, and neuroglial functional connection formation at the site of degeneration. Adverse effects of stem cell therapy, like teratogenicity and differentiation in different cells other than the desired one under the influence of microenvironment, are a few key concerns. Post-transplantation improved synaptic plasticity, apoptosis inhibition, and reduction in tau-phosphorylation and amyloid beta (Aβ) production has been observed in Alzheimer’s patients. A large number of experimental, preclinical, and clinical studies have been conducted, and encouraging results have been obtained. The present review exhaustively discusses various kinds of stem cells, their usage in treating neurodegenerative disorders, limitations and challenges, and ethical issues related to stem cell therapy.
Social Control of Hypothalamus-Mediated Male Aggression
Authors: Taehong Yang, Cindy F. Yang, M. Delara Chizari, Niru Maheswaranathan, Kenneth J. Burke, Maxim Borius, Sayaka Inoue, Michael C. Chiang, Kevin J. Bender, Surya Ganguli, Nirao M. Shah
Journal: Neuron (2024)
Establishment and validation of an artificial intelligence web application for predicting postoperative in-hospital mortality in patients with hip fracture: a National cohort study of 52,707 cases
Authors: Mingxing Lei, Taojin Feng, Min Chen, Junmin Shen, Jiang Liu, Feifan Chang, Junyu Chen, Xinyu Sun, Zhi Mao, Yi Li, Pengbin Yin, Peifu Tang, Licheng Zhang
Journal: International Journal of Surgery (2024)

In-hospital mortality following hip fractures is a significant concern, and accurate prediction of this outcome is crucial for appropriate clinical management. Nonetheless, there is a lack of effective prediction tools in clinical practice. By utilizing artificial intelligence (AI) and machine learning techniques, this study aims to develop a predictive model that can assist clinicians in identifying geriatric hip fracture patients at a higher risk of in-hospital mortality.
Novel locally nebulized indocyanine green for simultaneous identification of tumor margin and intersegmental plane
Authors: Ok Hwa Jeon, Kyungsu Kim, Chang Geun Kim, Byeong Hyeon Choi, Jun Hee Lee, Beop-Min Kim, Hyun Koo Kim
Journal: International Journal of Surgery (2024)

Segmentectomy, recommended for early-stage lung cancer or compromised lung function, demands precise tumor detection and intersegmental plane identification. While indocyanine green (ICG) commonly aids in these aspects using near-infrared imaging, its separate administrations through different routes and times can lead to complications and patient anxiety. This study aims to develop a lung-specific delivery method by nebulizing low-dose ICG to targeted lung segments, allowing simultaneous detection of lung tumors and intersegmental planes across diverse animal models.
Correspondence of “evaluation of large language models in breast cancer clinical scenarios: a comparative analysis based on ChatGPT-3.5, ChatGPT-4.0, and Claude2”
Authors: Fangchu Lo, Kahei Au, Wah Yang
Journal: International Journal of Surgery (2024)

aSchool of Medicine, Jinan University, Guangzhou, Guangdong Province, China bDepartment of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding AuthorAddress: Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, No. 613, Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong Province, China. Tel: +8615920373823. E-mail address: [email protected]; [email protected] (W. Yang). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Letter to the editor “Metabolic syndrome and surgical complications: a systematic review and meta-analysis of 13 million individuals”
Authors: Biao Zhang, Qihang Yuan, Dong Shang
Journal: International Journal of Surgery (2024)

aPancreas & Biliary Center, Department of General Surgery, Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China bInstitute (College) of Integrative Medicine, Dalian Medical University, Dalian 116011, Liaoning, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Pancreas & Biliary Center, Department of General Surgery, Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China. E-mail address: [email protected] (D. Shang). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A commentary on“Comparative long-term outcomes of natural orifice specimen extraction surgery and conventional laparoscopic colectomy for left-sided colorectal cancer: a propensity score-matched analysis”
Authors: Zechuan Wang, Qiang Hu, Fengru Zhou
Journal: International Journal of Surgery (2024)

aDepartment of Traditional Chinese Medicine,Community Health Service Center of Guali Town of Xiaoshan 180 Guayu RD,Hangzhou,311241,China bDepartment of general surgery,Tongde Hospital of Zhejiang Province 234 Gucui RD,Hangzhou,310012,China Zechuan Wang MD and Qiang Hu MD have equal contributions to the article. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of general surgery,Tongde Hospital of Zhejiang Province 234 Gucui RD,Hangzhou,310012,China. E-mail address: [email protected] (F. Zhou). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Hue selectivity from recurrent circuitry in Drosophila
Authors: Matthias P Christenson, Alvaro Sanz Diez, Sarah L Heath, Maia Saavedra-Weisenhaus, Atsuko Adachi, Aljoscha Nern, L F Abbott, Rudy Behnia
Journal: Nature Neuroscience (2024)

In the perception of color, wavelengths of light reflected off objects are transformed into the derived quantities of brightness, saturation and hue. Neurons responding selectively to hue have been reported in primate cortex, but it is unknown how their narrow tuning in color space is produced by upstream circuit mechanisms. We report the discovery of neurons in the Drosophila optic lobe with hue-selective properties, which enables circuit-level analysis of color processing. From our analysis of an electron microscopy volume of a whole Drosophila brain, we construct a connectomics-constrained circuit model that accounts for this hue selectivity. Our model predicts that recurrent connections in the circuit are critical for generating hue selectivity. Experiments using genetic manipulations to perturb recurrence in adult flies confirm this prediction. Our findings reveal a circuit basis for hue selectivity in color vision.
Two extracellular α-arabinofuranosidases are required for cereal-derived arabinoxylan metabolism by <i>Bifidobacterium longum</i> subsp. <i>longum</i>
Authors: Lisa Friess, Francesca Bottacini, Fionnuala M. McAuliffe, Ian J. O’Neill, Paul D. Cotter, Ciaran Lee, Jose Munoz-Munoz, Douwe van Sinderen
Journal: Gut Microbes (2024)

Members of the genus Bifidobacterium are commonly found in the human gut and are known to utilize complex carbohydrates that are indigestible by the human host. Members of the Bifidobacterium longum subsp. longum taxon can metabolize various plant-derived carbohydrates common to the human diet. To metabolize such polysaccharides, which include arabinoxylan, bifidobacteria need to encode appropriate carbohydrate-active enzymes in their genome. In the current study, we describe two GH43 family enzymes, denoted here as AxuA and AxuB, which are encoded by B. longum subsp. longum NCIMB 8809 and are shown to be required for cereal-derived arabinoxylan metabolism by this strain. Based on the observed hydrolytic activity of AxuA and AxuB, assessed by employing various synthetic and natural substrates, and based on in silico analyses, it is proposed that both AxuA and AxuB represent extracellular α-L-arabinofuranosidases with distinct substrate preferences. The variable presence of the axuA and axuB genes and other genes previously described to be involved in the metabolism of arabinose-containing glycans can in the majority cases explain the (in)ability of individual B. longum subsp. longum strains to grow on cereal-derived arabinoxylans and arabinan.
Lowering Blood Pressure in Stroke Patients in the Ambulance — A Bridge Too Close?
Authors: Jonathan A Edlow
Journal: New England Journal of Medicine (2024)

In The Prince, Niccolò Machiavelli wrote, "[W]ith those hectic fevers, as the doctors say, … at their beginning [they] are easy to cure but difficult to recognize, but in the course of time… [they] become easy to recognize but difficult to cure."1 As with Renaissance politics, so with stroke; time plays a critical role in diagnosis and treatment. Since 2008, the investigators in the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT) have been incrementally replacing opinion with evidence regarding the treatment of hypertension in patients with spontaneous intracerebral hemorrhage diagnosed by brain computed tomography (CT).2 Their current . . .
Safety and efficacy of active blood-pressure reduction to the recommended thresholds for intravenous thrombolysis in patients with acute ischaemic stroke in the Netherlands (TRUTH): a prospective, observational, cluster-based, parallel-group study
Authors: Thomas P Zonneveld, Sarah E Vermeer, Erik W van Zwet, Adrien E D Groot, Ale Algra, Leo A M Aerden, Kees C L Alblas, Frank de Beer, Paul J A M Brouwers, Koen de Gans, H Maarten A van Gemert, Bart C A M van Ginneken, Gerke S Grooters, Patricia H A Halkes, Tonny A M H G van der Heijden-Montfroy, Korné Jellema, Sonja W de Jong, Harry Lövenich-Ciccarello, Willem D M van der Meulen, Edwin W Peters, Taco C van der Ree, Michel J M Remmers, Edo Richard, Jörgen M P Rovers, Ritu Saxena, Sander M van Schaik, Wouter J Schonewille, Tobien A H C M L Schreuder, Els L L M de Schryver, Wouter J Schuiling, Fianne H Spaander, Julia H van Tuijl, Marieke C Visser, Sanne M Zinkstok, Elles Zock, Diederik W J Dippel, L Jaap Kappelle, Robert J van Oostenbrugge, Yvo B W E M Roos, Frederique H Vermeij, Marieke J H Wermer, H Bart van der Worp, Paul J Nederkoorn, Nyika D Kruyt
Journal: The Lancet Neurology (2024)
Randomized, Multicenter Study to Assess the Effects of Different Doses of Sildenafil on Mortality in Adults With Pulmonary Arterial Hypertension
Authors: Marius M. Hoeper, Ralf Ewert, Pavel Jansa, Yuriy Sirenko, Andris Skride, Cecile Balagtas, Sarah Hackley, Susanne Vogt, Paula Abreu, Scott Haughie, Tarek Hassan, Ronald J. Oudiz
Journal: Circulation (2024)

Sildenafil, approved for pulmonary arterial hypertension (PAH), has a recommended adult dose of 20 mg TID, with a previously approved 5-mg TID dose by the US Food and Drug Administration. Safety concerns arose because of common off-label use of higher doses, particularly after pediatric data linked higher doses to increased mortality. To assess this, the Food and Drug Administration mandated a study evaluating the effects of various sildenafil doses on mortality in adults with PAH.