tbuckley/cabot-search huggingface dataset:
Abstract 3774: Cost Effectiveness Of Enoxaparin In Patients With ST-elevation Myocardial Infarction: Results From EXTRACT-TIMI 25
Authors: Zefeng Zhang, Paul Kolm, Wei Zhang, Edward Ewen, Claudine Jurkovitz, Dogan Fidan, William Weintraub
Journal: Circulation (2007)

Background: The efficacy of enoxaparin versus unfractionated heparin in the setting of ST-elevation myocardial infarction (STEMI) has been demonstrated in EXTRACT-TIMI 25, with 17% reductions in relative risk in the primary endpoint of death or nonfatal recurrent myocardial infarction (MI) (p&lt;0.0001). This study considers the cost effectiveness of enoxaparin versus unfractionated heparin with fibrinolysis based on EXTRACT-TIMI 25. Methods: The ITT population of 20,479 patients from 48 countries were monitored for clinical and adverse events during the index hospitalization and through 30 days. Trial-wide resource utilization from all participating countries was used in the analysis while all costs were based on 2004 US costs. Medicare Fee Schedule was used for outpatient procedures and DRGs were applied for index and subsequent hospitalizations costs. Lost life years associated with 30-day in-trial events (death, MI and stroke) were estimated from published data from Framingham. Results: Overall, costs of index hospitalizations and outpatient procedures were lower, while costs for the subsequent hospitalization were higher for the enoxaparin patients. Total 30 days’ costs remained lower for enoxaparin, although the difference did not reach significance. Life years lost were significantly less with enoxaparin. For lifetime, when costs beyond the trial period were considered, the costs of enoxaparin in patients with STEMI were $506 higher, and the incremental cost-effectiveness ratio of enoxaparin compared to UFH was $4,369 per life year gained, with 99.9% of estimates falling below the $50,000 per life year gained threshold. Conclusions: Enoxaparin is effective in reducing mortality or nonfatal MI, and is highly cost-effective strategy in the US settings for the treatment of STEMI patients.
Abstract 3448: Differences in the Associations between Various Ultrasound-Based Markers of Peripheral Atherosclerosis at Carotid and Femoral Levels and Risk factors in a general Middle-Aged Population
Authors: Patrick O Yerly, Nicolas Rodondi, Fred Paccaud, Pierre Vogt, Pascal Bovet
Journal: Circulation (2007)

Introduction: Ultrasound detection of sub-clinical atherosclerosis (ATS) is a useful mean to identify subjects at high risk of cardiovascular (CV) events. Most studies have evaluated intima-media thickness (IMT) at the carotid artery level, but plaque-based markers (plaque thickness, plaque area) as well as the femoral artery level have been proposed as valid alternatives. The superiority of one method upon the others has not been demonstrated. The aim of this study is to compare the relationships between five indicators of ATS (IMT, mean / maximal plaque thickness, mean / maximal plaque area) at both carotid and femoral levels and conventional cardiovascular risk factors (CVRF) in a population-based sample of middle-aged adults. Methods: High resolution B-mode ultrasound was performed in both right and left carotid and femoral arteries on 496 consecutive participants aged 45– 64 randomly selected from the general population. A plaque was defined as a focal IMT thickening ≥ 1.2 mm. CVRF included age, sex, current smoking, systolic blood pressure, LDL-cholesterol, HDL-cholesterol, and diabetes. Results : All CVRF were associated, independently of age, with each of the ATS markers at femoral level but only LDL-cholesterol and systolic blood pressure were consistently associated with ATS markers at carotid level. The table shows the adjusted R-squared values in a multivariate model with all CVRF. Variance (adjusted R 2 ) in predicting any of the ATS markers was larger at femoral than carotid levels. At both carotid and femoral levels, the CVRF accounted for more variance in predicting plaque-based markers than IMT. Conclusion: The stronger association of CVRF with ATS markers at the femoral than carotid levels and with plaque-based markers than with IMT suggest that markers assessed at femoral level and based on plaque morphology might be the most useful tools for assessing cardiovascular risk. These findings need to be confirmed in prospective studies with CV events.
Abstract 18: Difficulty of Cardiac Arrest Rhythm Identification does not Correlate with Length of Chest Compression Pauses before Defibrillation
Authors: Benjamin S Abella, Salem Kim, Dana P Edelson, Raina M Merchant, Helge Myklebust, Anne M Barry, Terry L Vanden Hoek, Lance B Becker
Journal: Circulation (2006)

Background: Recent data suggest that the success of defibrillation during cardiac arrest depends on CPR performance immediately before shock delivery. Specifically, long pauses in chest compression...
Abstract 678: Administration of Intravenous High Density Lipoprotein Leads to Acute Changes in Human Atherosclerotic Plaque In Vivo
Authors: James A Shaw, Peter Blombery, Stuart Lyon, Dimitri Sviridov, Alex Bobik, Peter Kanellakis, Anthony M Dart
Journal: Circulation (2007)

Introduction High density lipoprotein (HDL) is an inverse predictor of cardiovascular events. Recent studies have shown a reduction in plaque volume and change in plaque ultrasound characteristics after 4 infusions of reconstituted HDL (r HDL CSL-111) given weekly over 1 month. Whether rHDL infusion leads to acute changes in plaque composition in vivo is not known. Methods Patients with symptom limiting claudication planned for percutaneous superficial femoral artery (sfa) revascularisation were randomised in a double blind manner to either placebo or IV r HDL (80mg/Kg given over 4 hrs). Prior to the treatment bloods were taken for measurement of lipid levels and inflammatory markers. 5–7 days following the infusion patients returned, repeat bloods were taken for lipids and inflammatory markers and revascularisation was performed including atherectomy (Foxhollow CA) to excise plaque from the sfa. Results 10 patients (9 male) average age 65 ± 10 yrs (mean ± sd) were recruited. 7 had a history of documented coronary artery disease and all patients were on aspirin and 8 on statins. 6 of the patients received r HDL and 4 placebo. There was a significant increase in Ankle brachial index in both groups after atherectomy (0.57 ± 0.22 to 0.92 ± 0.12 (p &lt; 0.01) in HDL gp, 0.58 ± 0.1 to 0.93 ± 0.05 (p &lt; 0.01) in placebo gp.) There were no significant differences in LDL, HDL or CRP after the infusion in either group. In the SFA plaque there was significantly less Vascular Cell Adhesion Molecule 1(VCAM1) staining (23 ± 8.7% vs 41.8 ± 2.7% p &lt; 0.05) and evidence of oxygen free radicals (31.5 ± 12.0 vs 90.3 ± 24.3 p &lt; 0.05 (arbitrary units)) in the HDL treated subjects compared to placebo. The amount of lipid in the plaque tended to be lower in the HDL group. Conclusion Intravenous infusion of 1 dose of reconstituted HDL leads to acute changes in plaque with a reduction in measures of inflammation and oxidised free radicals in subjects with peripheral vascular disease. These changes may explain the presumed cardioprotective effects of HDL.
Abstract 147: {beta}-Blockade Causes a Reduction in the Frequency Spectrum of Ventricular Fibrillation but Improves Resuscitation Outcome: A Potential Limitation of Quantitative Waveform Measures
Authors: Lawrence Sherman, James Niemann, Scott T Youngquist, Atman P Shah, John P Rosborough
Journal: Circulation (2011)

Background: Quantitative waveform measures (QWM), can predict defibrillation and restoration of spontaneous circulation (ROSC) in drug-naive animal models with normal coronary arteries. However, p...
Crizotinib Associated with Ground-Glass Opacity Predominant Pattern Interstitial Lung Disease: A Retrospective Observational Cohort Study with a Systematic Literature Review
Authors: Perrine Créquit, Marie Wislez, Jocelyne Fleury Feith, Nathalie Rozensztajn, Laurence Jabot, Sylvie Friard, Armelle Lavole, Valérie Gounant, Julie Fillon, Martine Antoine, Jacques Cadranel
Journal: Journal of Thoracic Oncology (2015)
Abstract 5375: Mutations of c-kit Receptor are Coupled with Impaired Growth and Enhanced Death of Cardiac Progenitor Cells
Authors: Adriana Bastos Carvalho, Cynthia Carrillo-Infante, Domenico D'Amario, M. Elena Padin-Iruegas, Caroline Ojaimi, Serena Vitale, Alessandro Gatti, Joao Ferreira-Martins, Hanqiao Zheng, Marcello Rota, Konrad Urbanek, Toru Hosoda, Annarosa Leri
Journal: Circulation (2008)
5-Year Clinical Outcomes After Sirolimus-Eluting Stent Implantation
Authors: Adriano Caixeta, Martin B. Leon, Alexandra J. Lansky, Eugenia Nikolsky, Jiro Aoki, Jeffrey W. Moses, Joachim Schofer, Marie-Claude Morice, Erick Schampaert, Ajay J. Kirtane, Jeffrey J. Popma, Helen Parise, Martin Fahy, Roxana Mehran
Journal: Journal of the American College of Cardiology (2009)
Abstract 14069: Feasibility of Assessment of Regional Function Using Wall Tension - Area Strain Loop Derived From Three-Dimensional Speckle Tracking Echocardiography
Authors: Ayana Hioki, Toshihiko Asanuma, Mariko Iwasaki, Kasumi Masuda, Satoshi Nakatani
Journal: Circulation (2010)

Background:  Recent advancement of three-dimensional (3D) speckle tracking echocardiography enables us to assess area strain as well as circumferential, radial and longitudinal strains. Area strain shows percent change of the pre-defined area on the endocardial layer during a cardiac cycle and is considered to be robust in assessing regional function. We investigated the feasibility of wall tension-area strain (T-AS) loops to assess regional function in the dog myocardial ischemia model.   Methods:  Three-dimensional full volume images were acquired using 3D echocardiography (Aplio Artida™, Toshiba) before and during brief occlusion of the left circumflex coronary artery in 8 dogs. Left ventricular (LV) pressure (P) was simultaneously recorded by a micromanometer-tipped catheter (Millar). LV short axis diameter (D) at the basal level and area strain were measured in the risk and normal areas. Wall tension (T) was calculated according to Laplace9s law for a spherical model as T = DP / 4. T-AS loop was constructed during one cardiac cycle. We calculated the ratio of wall tension to the area strain in end-systole as an index of regional function (slope of T-AS loop).   Results:  During coronary occlusion, the T-AS loop shifted rightward for the risk area while unchanged for the normal area. The slope of T-AS loop for the risk area was increased significantly and that for the normal area was not changed (before vs. during occlusion; −4.55 ± 2.20 vs. −54.4 ± 108 mmHg·cm·% −1 , p = 0.001 for the risk area, −2.78 ± 1.15 vs. −2.45 ± 1.08 mmHg·cm·% −1 , p=NS for the normal area, Figure).   Conclusions:  The wall tension — area strain loop well reflected regional dysfunction caused by myocardial ischemia. This analysis using 3D speckle tracking echocardiography may be useful to quantify regional function.
Abstract 1752: Impact of Early Mitral Regurgitation on Left Ventricular Remodeling and Heart Failure After Successful Angioplasty for Acute Myocardial Infarction
Authors: Nazario Carrabba, Guido Parodi, Merita Shehu, Renato Valenti, Gentian Memisha, Angela Migliorini, Giovanni M Santoro, David Antoniucci
Journal: Circulation (2006)
Abstract 15204: Modelling Pompe Glyocogen Storage Disease with Induced Pluripotent Stem Cells
Authors: Oren Feldman, Irit Huber, Aaron Winterstern, Amira Gepstein, Gil Arbel, Asaad Huri, Hana Mandel, Lior Gepstein
Journal: Circulation (2011)

Pompe disease (glyocogen storage disease type-II) is an inherited deficiency of acid α-glucosidase (GAA), a lysosomal enzyme required for glycogen breakdown. This results in accumulation of glycoge...
Abstract 4501: Decreasing In-hospital Mortality With Increasing Rate of Early PCI in Patients With ST Elevation Myocardial Infarction Complicated by Cardiogenic Shock: Results of the MITRA-Plus Registry
Authors: Uwe Zeymer, Ralf Zahn, Anselm Gitt, Koeth Oliver, Jochen Senges
Journal: Circulation (2009)

Background: STEMI complicated by cardiogenic shock is associated with a high in-hospital mortality. In the randomised SHOCK trial an early invasive strategy has improved the prognosis of these pati...
Abstract 3956: CD11b Positive Monocytes Are Required for Endothelial Regeneration
Authors: Nikos Werner, Bita Haghighat, Daniel Engel, Christian Kurts, Georg Nickenig, Sven Wassmann
Journal: Circulation (2008)

Bone marrow (BM)-derived circulating endothelial progenitor cells (EPC) contribute to endothelial cell (EC) regeneration. Systemic transfusion of EPC fosters the restoration of the endothelium after EC damage in mice. Transfusion of mononuclear cells (MNC) leads to an even more pronounced endothelial regeneration compared to EPCs. Here, we determine the role of monocytic cells and their interaction with circulating EPC on EC regeneration. To evaluate the effect of monocytes on re-endothelialization, neointima formation, and endothelial function, wild-type (WT) mice received repetitive intravenous injections of spleen-derived MNC, CD11b-depleted MNC, CD11b+ monocytes, or cell-free vehicle after EC denudation. Endothelial restoration was enhanced and neointima formation reduced after transfusion of MNC and CD11b+ cells. CD11b-depleted cells had no effect. Transfusion of CD11b+ cells in ApoE−/− mice improved endothelial-dependent vasorelaxation while CD11b-depleted cells had no effect. Next, WT mice were treated with clodronate liposomes (10μl/g bw) which induces the ablation of circulating monocytes. Re-endothelialization was diminished in clodronate- compared to vehicle-treated mice. Next, we selectively depleted CD11b+ monocytes using CD11b-DTR mice which express the human diphtheria toxin receptor (DTR) under the control of the CD11b promoter. Treatment with diphtheria toxin (DT) resulted in the complete ablation of circulating monocytes. Re-endothelialization was delayed in DT-treated compared to vehicle-treated mice. Systemic treatment of WT mice with Sca1+ EPC improves endothelial function. Repetitive transfusion of Sca1+ cells enhanced re-endothelialization in vehicle-treated CD11b-DTR mice compared to DT-treated mice. Rescue experiments showed that transfusion of CD11b+ cells in CD11b-DTR mice treated with either vehicle or DT resulted in a comparable enhancement of re-endothelialization. Our results indicate that circulating CD11b+ monocytes contribute to EC regeneration. Ablation of monocytes in vivo leads to a delay in re-endothelialization after focal EC damage which can not be rescued by transfusion of Sca1+ cells.
Abstract 16278: 10-Year Follow up Assessment of a Phase I Trial of Angiogenic Gene Therapy for the Treatment of Coronary Artery Disease Using Direct Intramyocardial Administration Vascular Endothelial Growth Factor 121
Authors: Muath M Bishawi, Michael S Halbreiner, Eileen Finnin, Annie L Shroyer, Ronald G Crystal, Todd K Rosengart
Journal: Circulation (2011)

Background:  Based on studies in experimental animals demonstrating that AdVEGF121, an E1-E3- serotype 5 adenovirus coding for the 121 isoform of vascular endothelial growth factor, could mandate the generation of new blood vessels and reverse coronary ischemia, clinical studies of direct myocardial administration of AdVEGF121 were initiated in patients with late stage coronary artery disease. This study provides long-term follow-up on these patients having undergone adenoviral-based administration of angiogenic mediators to the myocardium.   Methods:  From 1997 to 1999, AdVEGF was administered by direct myocardial injection to an area of reversible ischemia in 31 patients with severe coronary disease, either as an adjunct to conventional coronary artery bypass grafting (Group A, n = 15) or as sole therapy using a mini-thoracotomy (Group B, n = 16). Ten year follow-up was obtained for these patients.   Results:  Follow-up was complete in 29 (94%) of patients. The five year survival in Group A was 10/15 (67%) and 11/16 (69%) in Group B. Ten year survival was 6/15 (40%) and 5/16 (31%) for these patients, respectively. Mortality was associated with greater age and a higher incidence of diabetes and hypertension at the time of initial surgery. During the time of follow-up (median 11.8 years), four patients developed potentially treatment-related complications, including one patient with retinopathy and three patients (10%) with malignancies (one each with prostate cancer, colon cancer, and lymphoma/squamous cell cancer of the head), consistent with an expected 14% incidence of malignancy predicted in this age population. Several patients also underwent subsequent cardiac-related procedures, including repeat vascularization (n=5), ICD placement (n=6), and one cardiac transplantation. At ten year follow- up, five of the six living Group A patients and three of the four living Group B patients (excluding the transplant) had a CCS Angina Class of 1 or 2.   Conclusion:  This small case series of high-risk patients that received myocardial administration of AdVEGF documents that AdVEGF may be safely administered with minimal long term related morbidity and mortality. Future larger trials appear warranted to confirm these preliminary findings.
Abstract 569: Selective Elimination of IKs and IKr in Transgenic Rabbit Models of LQT1 and LQT2
Authors: Gong Xin Liu, Naveed Rana, Mohammad Hajjiri, Michael Brunner, Eduardo Folco, Ekaterina Pringa, Jason Centracchio, Malcolm Kirk, Manfred Zehender, Xuwen Peng, Gideon Koren
Journal: Circulation (2006)

LQT1 and LQT2, the two most common inherited long QT syndromes are associated with sudden cardiac death due to due torsades the pointes (TdP). We have created two lines of transgenic rabbits overex...
Three-Year Follow-Up Data and Characterization Of Long-Term Remissions From An Ongoing Phase 2 Study Of Brentuximab Vedotin In Patients With Relapsed Or Refractory Hodgkin Lymphoma
Authors: Ajay K. Gopal, Robert Chen, Scott E. Smith, Stephen M Ansell, Joseph D Rosenblatt, Kerry J. Savage, Joseph M. Connors, Andreas Engert, Emily K. Larsen, Dirk Huebner, Eric L. Sievers, Anas Younes
Journal: Blood (2013)
Multiple Primary Maligant Neoplasia in three Members of a Family
Authors: G S Kenyon
Journal: Journal of the Royal Society of Medicine (1981)

Three members of a family have presented in adult life with a succession of invasive malignancies. No known premalignant condition has been apparent in this group, and a limited study of immune competence has failed to reveal any abnormality. In spite of this there is strong evidence to suggest a so far undetected immunogenetic abnormality as the basis of this phenomenon.
Abstract 12688: Extracellular Matrix Alterations after Sinus Rhythm Restoration in Patients with Persistent Atrial Fibrillation.
Authors: Eleftherios M Kallergis, Emmanuel M Kanoupakis, Hercules E Mavrakis, Christos A Goudis, Ilias G Saloustros, Emmanuel p Koutalas, Niki E Malliaraki, Maria E Milathianaki, Emmanuel G Manios, Panos E Vardas
Journal: Circulation (2010)

Collagen turnover and atrial fibrosis have been implicated in the generation and perpetuation of AF. To evaluate the importance of serum markers of collagen turnover in predicting the outcome of electrical cardioversion (CV) of persistent atrial fibrillation (AF) and to clarify the relationship between AF and fibrosis, serum C-terminal propeptide of collagen type I (CICP) and C-terminal telopeptide of collagen type I (CITP) were measured in 98 patients with AF before and two months after CV. All patients were successfully cardioverted to sinus rhythm (SR) although in 23 of them AF recurred. Baseline CICP levels were comparable in patients in sinus rhythm 60 days after CV and in those who experienced a relapse of AF (82.464±16.65 ng/ml vs. 86.45±10.95 ng/ml, respectively, p=0.18). Baseline CITP levels were significantly higher in patients with AF recurrence compared to those who remained in SR (0.47±0.15 ng/ml vs. 0.33±0.19 ng/ml,respectively, p=0.001). The restoration and maintenance of SR resulted in a decrease of CICP but not of CITP levels.In the 75 patients who maintained SR, CICP levels were significantly lower at the end of the study as compared to baseline, (61.89±14.18 ng/ml vs. 82.464±16.65 ng/ml p
Abstract 13559: Gender Does Not Impact Post-Discharge Outcomes in Patients Hospitalized for Worsening Heart Failure with Reduced Ejection Fraction in the EVEREST Trial
Authors: Ami Shah, John Blair, Mihai Gheorghiade, Andrew P Ambrosy, Robert J Mentz, Angela J Fought, Mary J Kwasny, Aldo P Maggioni, Karl Swedberg, Faiez Zannad, Marvin A Konstam
Journal: Circulation (2011)

Background: Women represent about half of patients hospitalized for acute heart failure (HF). However, they have traditionally been underrepresented in HF trials. Hypothesis: Women have a better po...
Targetable genetic features of primary testicular and primary central nervous system lymphomas
Authors: Bjoern Chapuy, Margaretha G. M. Roemer, Chip Stewart, Yuxiang Tan, Ryan P. Abo, Liye Zhang, Andrew J. Dunford, David M. Meredith, Aaron R. Thorner, Ekaterina S. Jordanova, Gang Liu, Friedrich Feuerhake, Matthew D. Ducar, Gerald Illerhaus, Daniel Gusenleitner, Erica A. Linden, Heather H. Sun, Heather Homer, Miyuki Aono, Geraldine S. Pinkus, Azra H. Ligon, Keith L. Ligon, Judith A. Ferry, Gordon J. Freeman, Paul van Hummelen, Todd R. Golub, Gad Getz, Scott J. Rodig, Daphne de Jong, Stefano Monti, Margaret A. Shipp
Journal: Blood (2015)
Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer
Authors: Oriol Arqués, Irene Chicote, Isabel Puig, Stephan P. Tenbaum, Guillem Argilés, Rodrigo Dienstmann, Natalia Fernández, Ginevra Caratù, Judit Matito, Daniel Silberschmidt, Jordi Rodon, Stefania Landolfi, Aleix Prat, Eloy Espín, Ramón Charco, Paolo Nuciforo, Ana Vivancos, Wenlin Shao, Josep Tabernero, Héctor G. Palmer
Journal: Clinical Cancer Research (2015)

Oncogenic mutations in the KRAS/PI3K/AKT pathway are one of the most frequent alterations in cancer. Although PI3K or AKT inhibitors show promising results in clinical trials, drug resistance frequently emerges. We previously revealed Wnt/β-catenin signaling hyperactivation as responsible for such resistance in colorectal cancer. Here we investigate Wnt-mediated resistance in patients treated with PI3K or AKT inhibitors in clinical trials and evaluate the efficacy of a new Wnt/tankyrase inhibitor, NVP-TNKS656, to overcome such resistance.Colorectal cancer patient-derived sphere cultures and mouse tumor xenografts were treated with NVP-TNKS656, in combination with PI3K or AKT inhibitors.We analyzed progression-free survival of patients treated with different PI3K/AKT/mTOR inhibitors in correlation with Wnt/β-catenin pathway activation, oncogenic mutations, clinicopathological traits, and gene expression patterns in 40 colorectal cancer baseline tumors.Combination with NVP-TNKS656 promoted apoptosis in PI3K or AKT inhibitor-resistant cells with high nuclear β-catenin content. High FOXO3A activity conferred sensitivity to NVP-TNKS656 treatment. Thirteen of 40 patients presented high nuclear β-catenin content and progressed earlier upon PI3K/AKT/mTOR inhibition. Nuclear β-catenin levels predicted drug response, whereas clinicopathologic traits, gene expression profiles, or frequent mutations (KRAS, TP53, or PIK3CA) did not.High nuclear β-catenin content independently predicts resistance to PI3K and AKT inhibitors. Combined treatment with a Wnt/tankyrase inhibitor reduces nuclear β-catenin, reverts such resistance, and represses tumor growth. FOXO3A content and activity predicts response to Wnt/β-catenin inhibition and together with β-catenin may be predictive biomarkers of drug response providing a rationale to stratify colorectal cancer patients to be treated with PI3K/AKT/mTOR and Wnt/β-catenin inhibitors.