tbuckley/cabot-search huggingface dataset:
Processed microalgae: green gold for tissue regeneration and repair
Authors: Sen Liu, Ling Shi, Hailong Luo, Kaiyuan Chen, Meichen Song, Yingjun Wu, Fengzhi Liu, Meng Li, Jie Gao, Yan Wu
Journal: Theranostics (2024)

As novel biomedical materials, microalgae have garnered significant interest because of their ability to generate photosynthetic oxygen, their antioxidant activity, and their favorable biocompatibility. Many studies have concentrated on the hypoxia-alleviating effects of microalgae within tumor microenvironments. However, recent findings indicate that microalgae can significantly increase the regeneration of various tissues and organs. To augment microalgae's therapeutic efficacy and mitigate the limitations imposed by immune clearance, it is essential to process microalgae through various processing strategies. This review examines common microalgal species in biomedical applications, such as
EBV-associated epithelial cancers cells promote vasculogenic mimicry formation via a secretory cross-talk with the immune microenvironment
Authors: Tong Xiang, Fengze Sun, Tingting Liu, Jingjing Zhao, Jieying Yang, Dijun Ouyang, Hao Chen, Qian Zhu, Qijing Wang, Yongqiang Li, Jia He, Chaopin Yang, Xinyi Yang, Yuanyuan Chen, Yan Tang, Desheng Weng, Qiuzhong Pan, Qi Yang, Jianchuan Xia
Journal: Theranostics (2024)

Vasculogenic mimicry (VM) induced by Epstein-Barr virus (EBV) infection plays an important role in resistance to anti-vascular endothelial growth factor (VEGF) therapy in EBV-associated epithelial cancers; however, the interaction between VM and the immune microenvironment has not been systematically investigated.
Engaging natural regulatory myeloid cells to restrict T-cell hyperactivation-induced liver inflammation via extracellular vesicle-mediated purine metabolism regulation
Authors: Fan Yang, Ruoting Men, Linling Lv, Leyu Zhou, Qiaoyu Deng, Xianglin Wang, Jingping Liu, Li Yang
Journal: Theranostics (2024)

Dysregulated T-cell immune response-mediated inflammation plays critical roles in the pathology of diverse liver diseases, but the underlying mechanism of liver immune homeostasis control and the specific therapies for limiting T-cell overactivation remain unclear.
Microenvironment-responsive nanosystems for ischemic stroke therapy
Authors: Fang Wu, Zhijian Zhang, Shengnan Ma, Yanyan He, Yuxi He, Lixia Ma, Ningjing Lei, Wenjing Deng, Fazhan Wang
Journal: Theranostics (2024)

Ischemic stroke, a common neurological disorder caused by impaired blood supply to the brain, presents a therapeutic challenge. Conventional treatments like thrombolysis and neuroprotection drugs lack ideal drug delivery systems, limiting their effectiveness. Selectively delivering therapies to the ischemic cerebral tissue holds great potential for preventing and/or treating ischemia-related pathological symptoms. The unique pathological microenvironment of the brain after ischemic stroke, characterized by hypoxia, acidity, and inflammation, offers new possibilities for targeted drug delivery. Pathological microenvironment-responsive nanosystems, extensively investigated in tumors with hypoxia-responsive systems as an example, could also respond to the ischemic cerebral microenvironment and achieve brain-targeted drug delivery and release. These emerging nanosystems are gaining traction for ischemic stroke treatment. In this review, we expound on the cerebral pathological microenvironment and clinical treatment strategies of ischemic stroke, highlight various stimulus-responsive materials employed in constructing ischemic stroke microenvironment-responsive nano delivery systems, and discuss the application of these microenvironment-responsive nanosystems in microenvironment regulation for ischemic stroke treatment.
βAR-mTOR-lipin1 pathway mediates PKA-RIIβ deficiency-induced adipose browning
Authors: Bingwei Wang, Zhiping Hu, Long Cui, Miao Zhao, Zhijie Su, Yong Jiang, Jiarui Liu, Yun Zhao, Yujia Hou, Xiaoning Yang, Chenyu Zhang, Bingbing Guo, Daotong Li, Liang Zhao, Shengmin Zheng, Yiguo Zhao, Weipeng Yang, Dunfang Wang, Siwang Yu, Shigong Zhu, Yi Yan, Geheng Yuan, Kailong Li, Wenqiang Zhang, Lihua Qin, Weiguang Zhang, Feng Sun, Jianyuan Luo, Ruimao Zheng
Journal: Theranostics (2024)

Enhancing white adipose tissue (WAT) browning combats obesity. The RIIβ subunit of cAMP-dependent protein kinase (PKA) is primarily expressed in the brain and adipose tissue. Deletion of the hypothalamic RIIβ gene centrally induces WAT browning, yet the peripheral mechanisms mediating this process remain unexplored.
Theranostics with somatostatin receptor antagonists in SCLC: Correlation of <sup>68</sup>Ga-SSO120 PET with immunohistochemistry and survival
Authors: Ilektra Antonia Mavroeidi, Anna Romanowicz, Tristan Haake, Johannes Wienker, Martin Metzenmacher, Kaid Darwiche, Filiz Oezkan, Servet Bölükbas, Martin Stuschke, Lale Umutlu, Marcel Opitz, Michael Nader, Rainer Hamacher, Jens Siveke, Jane Winantea, Wolfgang P Fendler, Marcel Wiesweg, Wilfried E E Eberhardt, Ken Herrmann, Dirk Theegarten, Martin Schuler, Hubertus Hautzel, David Kersting
Journal: Theranostics (2024)

Positron Emission Tomography (PET) using the somatostatin receptor 2 (SSTR2)-antagonist satoreotide trizoxetan (
Honokiol enhances the sensitivity of cetuximab in KRAS<sup>G13D</sup> mutant colorectal cancer through destroying SNX3-retromer complex
Authors: Qianru Zhu, Ruonan Zhang, Xiaoqing Gu, Ziming Zhao, Quan Gao, Min Chen, Qibiao Wu, Tian Xie, Xinbing Sui
Journal: Theranostics (2024)

: the proto-oncogene
The role of m6A-associated membraneless organelles in the RNA metabolism processes and human diseases
Authors: Fang-Tian Bu, Hai-Yan Wang, Chao Xu, Kang-Li Song, Zhen Dai, Lin-Ting Wang, Jie Ying, Jianxiang Chen
Journal: Theranostics (2024)

6-methyladenosine (m6A) is the most abundant post-transcriptional dynamic RNA modification process in eukaryotes, extensively implicated in cellular growth, embryonic development and immune homeostasis. One of the most profound biological functions of m6A is to regulate RNA metabolism, thereby determining the fate of RNA. Notably, the regulation of m6A-mediated organized RNA metabolism critically relies on the assembly of membraneless organelles (MLOs) in both the nucleus and cytoplasm, such as nuclear speckles, stress granules and processing bodies. In addition, m6A-associated MLOs exert a pivotal role in governing diverse RNA metabolic processes encompassing transcription, splicing, transport, decay and translation. However, emerging evidence suggests that dysregulated m6A levels contribute to the formation of pathological condensates in a range of human diseases, including tumorigenesis, reproductive diseases, neurological diseases and respiratory diseases. To date, the molecular mechanism by which m6A regulates the aggregation of biomolecular condensates associated with RNA metabolism is unclear. In this review, we comprehensively summarize the updated biochemical processes of m6A-associated MLOs, particularly focusing on their impact on RNA metabolism and their pivotal role in disease development and related biological mechanisms. Furthermore, we propose that m6A-associated MLOs could serve as predictive markers for disease progression and potential drug targets in the future.
Lutetium-177-PSMA therapy for recurrent/metastatic salivary gland cancer: a prospective pilot study
Authors: Niels J van Ruitenbeek, Maike J M Uijen, Chantal M L Driessen, Steffie M B Peters, Bastiaan M Privé, Adriana C H van Engen-van Grunsven, Mark W Konijnenberg, Martin Gotthardt, James Nagarajah, Carla M L van Herpen
Journal: Theranostics (2024)

There is an urgent need for novel systemic therapies for recurrent/systemic salivary gland cancer, as current treatment options are scarce. [
Transcriptome analysis reveals EBF1 ablation-induced injuries in cardiac system
Authors: Yueheng Wu, Shaoxian Chen, Guiping Huang, Lu Zhang, Liying Zhong, Yi Feng, Pengju Wen, Juli Liu
Journal: Theranostics (2024)

Regulatory processes of transcription factors (TFs) shape heart development and influence the adult heart's response to stress, contributing to cardiac disorders. Despite their significance, the precise mechanisms underpinning TF-mediated regulation remain elusive. Here, we identify that EBF1, as a TF, is highly expressed in human heart tissues. EBF1 is reported to be associated with human cardiovascular disease, but its roles are unclear in heart. In this study, we investigated EBF1 function in cardiac system.
IL-33/ST2 induces macrophage-dependent ROS production and TRPA1 activation that mediate pain-like responses by skin incision in mice
Authors: Ruoyao Xu, Yushuang Pan, Kaige Zheng, Muyan Chen, Chengyu Yin, Qimiao Hu, Jie Wang, Qing Yu, Peiyi Li, Yan Tai, Junfan Fang, Boyu Liu, Jianqiao Fang, Guihua Tian, Boyi Liu
Journal: Theranostics (2024)

Insufficiently managed incisional (INC) pain severely affects patients' life quality and rehabilitation after a major operation. However, mechanisms underlying INC pain still remain poorly understood.
Bisecting GlcNAc modification reverses the chemoresistance via attenuating the function of P-gp
Authors: Zengqi Tan, Lulu Ning, Lin Cao, Yue Zhou, Jing Li, Yunyun Yang, Shuai Lin, Xueting Ren, Xiaobo Xue, Huafeng Kang, Xiang Li, Feng Guan
Journal: Theranostics (2024)

Chemoresistance is a key factor contributing to the failure of anti-breast cancer chemotherapy. Although abnormal glycosylation is closely correlated with breast cancer progression, the function of glycoconjugates in chemoresistance remains poorly understood.
The principles and promising future of sonogenetics for precision medicine
Authors: Pengying Wu, Zhaoyou Liu, Wenxin Tao, Yubo Lai, Guodong Yang, Lijun Yuan
Journal: Theranostics (2024)

Sonogenetics is an emerging medical technology that uses acoustic waves to control cells through sonosensitive mediators (SSMs) that are genetically encoded, thus remotely and non-invasively modulating specific molecular events and/or biomolecular functions. Sonogenetics has opened new opportunities for targeted spatiotemporal manipulation in the field of gene and cell-based therapies due to its inherent advantages, such as its noninvasive nature, high level of safety, and deep tissue penetration. Sonogenetics holds impressive potential in a wide range of applications, from tumor immunotherapy and mitigation of Parkinsonian symptoms to the modulation of neural reward pathway, and restoration of vision. This review provides a detailed overview of the mechanisms and classifications of established sonogenetics systems and summarizes their applications in disease treatment and management. The review concludes by highlighting the challenges that hinder the further progress of sonogenetics, paving the way for future advances.
Energy level as a theranostic factor for successful therapy of tissue injuries with polyphosphate: the triad metabolic energy - mechanical energy - heat
Authors: Werner E G Müller, Hadrian Schepler, Meik Neufurth, Rita Dobmeyer, Renato Batel, Heinz C Schröder, Xiaohong Wang
Journal: Theranostics (2024)

Tissue regeneration of skin and bone is an energy-intensive, ATP-consuming process that, if impaired, can lead to the development of chronic clinical pictures. ATP levels in the extracellular space including the exudate of wounds, especially chronic wounds, are low. This deficiency can be compensated by inorganic polyphosphate (polyP) supplied
Photoreceptor-targeted extracellular vesicles-mediated delivery of Cul7 siRNA for retinal degeneration therapy
Authors: Dong Guo, Yuntong Sun, Junqi Wu, Linchao Ding, Yiwen Jiang, Yadong Xue, Yongjun Ma, Fengtian Sun
Journal: Theranostics (2024)

Photoreceptor loss is a primary pathological feature of retinal degeneration (RD) with limited treatment strategies. RNA interference (RNAi) has emerged as a promising method of gene therapy in regenerative medicine. However, the transfer of RNAi therapeutics to photoreceptors and the deficiency of effective therapeutic targets are still major challenges in the treatment of RD.
SEMA6B induces macrophage-mediated inflammation and hepatocyte apoptosis in hepatitis B virus-related acute-on-chronic liver failure
Authors: Hui Yang, Qun Cai, Jiaojiao Xin, Xi Liang, Hozeifa Mohamed Hassan, Jiaxian Chen, Lulu He, Suwan Sun, Beibei Guo, Shiwen Ma, Bingqi Li, Xiaofei Zeng, Meiqian Hu, Peng Li, Jinjin Luo, Wen Hu, Heng Yao, Xingping Zhou, Yuheng Kong, Qiuzhi Wang, Xin Chen, Jing Jiang, Dongyan Shi, Jun Li
Journal: Theranostics (2024)

Patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) have a high short-term mortality rate. Semaphorin-6B (SEMA6B) plays a crucial role in the pathogenesis of HBV-ACLF, but its molecular basis remains unclear. This study aimed to elucidate the mechanisms of SEMA6B in HBV-ACLF progression.
MCT1-mediated endothelial cell lactate shuttle as a target for promoting axon regeneration after spinal cord injury
Authors: Chaoran Shi, Jiaqi Xu, Yinghe Ding, Xingyi Chen, Feifei Yuan, Fengzhang Zhu, Chunyue Duan, Jianzhong Hu, Hongbin Lu, Tianding Wu, Liyuan Jiang
Journal: Theranostics (2024)

Spinal cord injury (SCI)-induced vascular damage causes ischemia and hypoxia at the injury site, which, in turn, leads to profound metabolic disruptions. The effects of these metabolic alterations on neural tissue remodeling and functional recovery have yet to be elucidated. The current study aimed to investigate the consequences of the SCI-induced hypoxic environment at the epicenter of the injury.
Apoptotic vesicle-mediated senolytics requires mechanical loading
Authors: Zhulin Xue, Yexiang Jiang, Bowen Meng, Lu Lu, Meng Hao, Yi Zhang, Songtao Shi, Zili Li, Xueli Mao
Journal: Theranostics (2024)

Mechanical force plays crucial roles in extracellular vesicle biogenesis, release, composition and activity. However, it is unknown whether mechanical force regulates apoptotic vesicle (apoV) production.
Parkin plays a crucial role in acute viral myocarditis by regulating mitophagy activity
Authors: Yixuan Qiu, Jing Xu, Yilian Chen, Yihao Wu, Yuan-Nan Lin, Weike Liu, Zhening Wang, Yuqing Wu, Xinge Qian, Yue-Chun Li
Journal: Theranostics (2024)

Parkin (an E3 ubiquitin protein ligase) is an important regulator of mitophagy. However, the role of Parkin in viral myocarditis (VMC) remains unclear.
Metal-organic cage as a theranostic nanoplatform for magnetic resonance imaging guided chemodynamic therapy
Authors: Peilin Yin, Demei Sun, Yucen Deng, Xinyuan Zhu, Youfu Wang, Jinghui Yang, Xuesong Feng
Journal: Theranostics (2024)

Theranostic nanoplatforms exert a vital role in facilitating concurrent real-time diagnosis and on-demand treatment of diseases, thereby making contributions to the improvement of therapeutic efficacy. Nevertheless, the structural intricacy and the absence of well-defined integration of dual functionality persist as challenges in the development of theranostic nanoplatforms.
The m6A reader YTHDC2 promotes the pathophysiology of temporal lobe epilepsy by modulating SLC7A11-dependent glutamate dysregulation in astrocytes
Authors: Kai Zhang, Zhiquan Yang, Zhuanyi Yang, Liangchao Du, Yu Zhou, Shiyu Fu, Xiaoyue Wang, Xing Li, Dingyang Liu, Xinghui He
Journal: Theranostics (2024)

Epilepsy affects over 70 million people globally, with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) often progressing to a drug-resistant state. Recent research has highlighted the role of reactive astrocytes and glutamate dysregulation in epilepsy pathophysiology. This study aims to investigate the involvement of astrocytic xCT, a glutamate-cystine antiporter, and its regulation by the m6A reader protein YTHDC2 in TLE-HS.
<i>DAB2</i><sup>+</sup> macrophages support <i>FAP</i><sup>+</sup> fibroblasts in shaping tumor barrier and inducing poor clinical outcomes in liver cancer
Authors: Fei Long, Wei Zhong, Faming Zhao, Yaqi Xu, Xin Hu, Gaihua Jia, Lanxiang Huang, Kezhen Yi, Na Wang, Huaqi Si, Jun Wang, Bicheng Wang, Yuan Rong, Yufeng Yuan, Chunhui Yuan, Fubing Wang
Journal: Theranostics (2024)

Cancer-associated fibroblasts (CAFs) are the key components of the immune barrier in liver cancer. Therefore, gaining a deeper understanding of the heterogeneity and intercellular communication of CAFs holds utmost importance in boosting immunotherapy effectiveness and improving clinical outcomes.
The heterobivalent (SSTR2/albumin) radioligand [<sup>67</sup>Cu]Cu-NODAGA-cLAB4-TATE enables efficient somatostatin receptor radionuclide theranostics
Authors: Martin Ullrich, Robert Wodtke, Florian Brandt, Robert Freudenberg, Jörg Kotzerke, Susan Richter, Klaus Kopka, Jens Pietzsch
Journal: Theranostics (2024)

Somatostatin type 2 receptor (SSTR2) radionuclide therapy using β
A relay-type innate immunity activation strategy involving water-soluble NIR-II AIEgen for boosted tumor photo-immunotherapy
Authors: Shanshan Liu, Yan Sun, Dingyuan Yan, Wen Song, Jiajia Fu, Shanyong Wang, Tianhao Yang, Jun Zhu, Dongxia Zhu, Dong Wang, Feifan Zhou, Ben Zhong Tang
Journal: Theranostics (2024)

Effective innate immunity activation could dramatically improve the anti-tumor efficacy and increase the beneficiary population of immunotherapy. However, the anti-tumor effect of unimodal immunotherapy is still not satisfactory.
Single-cell RNA sequencing highlights the immunosuppression of IDO1<sup>+</sup> macrophages in the malignant transformation of oral leukoplakia
Authors: Yu Zhang, Jie Zhang, Simin Zhao, Yan Xu, Yingying Huang, Shaopeng Liu, Peng Su, Caijiao Wang, Yahui Li, Hao Li, Pishan Yang, Chengzhe Yang
Journal: Theranostics (2024)

: Immunosuppressive tumor microenvironment (iTME) plays an important role in carcinogenesis, and some macrophage subsets are associated with iTME generation. However, the sub-population characterization of macrophages in oral carcinogenesis remains largely unclear. Here, we investigated the immunosuppressive status with focus on function of a macrophage subset that expressed indoleamine 2,3 dioxygenase 1 (Macro-IDO1) in oral carcinogenesis.
Oncofetal TRIM71 drives liver cancer carcinogenesis through remodeling CEBPA-mediated serine/glycine metabolism
Authors: Ying Su, Ziteng Li, Qin Li, Xinyi Guo, Hena Zhang, Yan Li, Zhiqiang Meng, Shenglin Huang, Zhixiang Hu
Journal: Theranostics (2024)

Tumor cells remodel transcriptome to construct an ecosystem with stemness features, which maintains tumor growth and highly malignant characteristics. However, the core regulatory factors involved in this process still need to be further discovered.
Targeted degradation of VEGF with bispecific aptamer-based LYTACs ameliorates pathological retinal angiogenesis
Authors: Ping Zhou, Sai Zhang, Lin Li, Renshuai Zhang, Guizhi Guo, Yufei Zhang, Runa Wang, Miaoyuan Liu, Zhiyi Wang, Huijie Zhao, Guiwen Yang, Songbo Xie, Jie Ran
Journal: Theranostics (2024)

Neovascular ocular diseases (NODs) represent the leading cause of visual impairment globally. Despite significant advances in anti-angiogenic therapies targeting vascular endothelial growth factor (VEGF), persistent challenges remain prevalent. As a proof-of-concept study, we herein demonstrate the effectiveness of targeted degradation of VEGF with bispecific aptamer-based lysosome-targeting chimeras (referred to as VED-LYTACs).
Milk-derived extracellular vesicles enable gut-to-tumor oral delivery of tumor-activated doxorubicin prodrugs
Authors: Hochung Jang, Jiwoong Choi, Daeho Park, Geonhee Han, Eun Hye Kim, Kwangmeyung Kim, Sun Hwa Kim, Man Kyu Shim, Yoosoo Yang
Journal: Theranostics (2024)

Oral chemotherapy has been emerging as a hopeful therapeutic regimen for the treatment of various cancers because of its high safety and convenience, lower costs, and high patient compliance. Despite the current advancements in nanoparticle-mediated drug delivery, numerous anticancer drugs susceptible to the hostile gastrointestinal (GI) environment exhibit poor permeability across the intestinal epithelium, rendering them ineffective in providing therapeutic benefits. In this paper, we focus on harnessing milk-derived extracellular vesicles (mEVs) for gut-to-tumor oral drug delivery by leveraging their high bioavailability.
Impact of Skin Care Products on Phthalates and Phthalate Replacements in Children: the ECHO-FGS
Authors: Michael S. Bloom, Juliana M. Clark, John L. Pearce, Pamela L. Ferguson, Roger B. Newman, James R. Roberts, William A. Grobman, Anthony C. Sciscione, Daniel W. Skupski, Kelly Garcia, John E. Vena, Kelly J. Hunt
Journal: Environmental Health Perspectives (2024)

Phthalates and their replacements have been implicated as developmental toxicants. Young children may be exposed to phthalates/replacements when using skin care products (SCPs).
Activation of Toll-like receptor 2 promotes mesenchymal stem/stromal cell-mediated immunoregulation and angiostasis through AKR1C1
Authors: Jung Hwa Ko, Hyun Ju Lee, Chang Ho Yoon, Yoo Rim Choi, Jin Suk Ryu, Joo Youn Oh
Journal: Theranostics (2024)

Mesenchymal stem/stromal cells (MSCs) maintain tissue homeostasis in response to microenvironmental perturbations. Toll-like receptors (TLRs) are key sensors for exogenous and endogenous signals produced during injury. In this study, we aimed to investigate whether TLRs affect the homeostatic functions of MSCs after injury.
Nanomedicines as Guardians of the Heart: Unleashing the Power of Antioxidants to Alleviate Myocardial Ischemic Injury
Authors: Dongjian Han, Fuhang Wang, Deliang Shen
Journal: Theranostics (2024)

Ischemic heart disease (IHD) is increasingly recognized as a significant cardiovascular disease with a growing global incidence. Interventions targeting the oxidative microenvironment have long been pivotal in therapeutic strategies. However, many antioxidant drugs face limitations due to pharmacokinetic and delivery challenges, such as short half-life, poor stability, low bioavailability, and significant side effects. Fortunately, nanotherapies exhibit considerable potential in addressing IHD. Nanomedicines offer advantages such as passive/active targeting, prolonged circulation time, enhanced bioavailability, and diverse carrier options. This comprehensive review explores the advancements in nanomedicines for mitigating IHD through oxidative stress regulation, providing an extensive overview for researchers in the field of antioxidant nanomedicines. By inspiring further research, this study aims to accelerate the development of novel therapies for myocardial injury.
Mitochondria-encoded peptide MOTS-c participates in plasma membrane repair by facilitating the translocation of TRIM72 to membrane
Authors: Hong Jia, Lyu-Chen Zhou, Yong-Feng Chen, Wei Zhang, Wei Qi, Peng Wang, Xiao Huang, Jian-Wei Guo, Wai-Fang Hou, Ran-Ran Zhang, Jing-Jun Zhou, Da-Wei Zhang
Journal: Theranostics (2024)

An impairment of plasma membrane repair has been implicated in various diseases such as muscular dystrophy and ischemia/reperfusion injury. MOTS-c, a short peptide encoded by mitochondria, has been shown to pass through the plasma membrane into the bloodstream. This study determined whether this biological behavior was involved in membrane repair and its underlying mechanism.
Brain-targeted intranasal delivery of protein-based gene therapy for treatment of ischemic stroke
Authors: Jee-Yeon Ryu, Christian Cerecedo-Lopez, Hongkuan Yang, Ilhwan Ryu, Rose Du
Journal: Theranostics (2024)

Gene therapy using a protein-based CRISPR system in the brain has practical limitations due to current delivery systems, especially in the presence of arterial occlusion. To overcome these obstacles and improve stability, we designed a system for intranasal administration of gene therapy for the treatment of ischemic stroke.