tbuckley/cabot-search huggingface dataset:
Abstract 17532: How to Assess the Best Left Atrial Function by Speckle Tracking: Recommendations for a Standard Method
Authors: Roxana Cristina Rimbas, Sorina Mihaila, Raluca Elena Dulgheru, Dragos Vinereanu
Journal: Circulation (2011)

2D speckle-tracking echocardiography (STE) is a novel, feasible technique for the assessment of longitudinal myocardial left atrial (LA) function. Normal ranges, and also cutoff values to diagnose LA dysfunction with different diseases have been reported. However, 2 different methods, based on P-wave and R-wave as the reference point for generation of strain curves, have been used. Therefore, we compared these 2 methods, in order to define which one provides the most correct assessment of all LA functions. Methods: 20 normal subjects (46±14 yrs, 11 men) with adequate 2D images in 4C view were evaluated for LA function by STE. We used 2 different methodologies, P-wave and R-wave as a reference point, for the evaluation of LA strain, strain rate, and derived times. Active LA function was assessed from negative global strain at atrial contraction (GSA-), time from P to peak negative strain (TGSA-), and late diastolic strain rate (GSRL); passive function from positive global strain at AVC (GSA1+) and at MVO (GSA2+), and time from R-wave to both peaks (TGSA1 and TGSA2), late positive global strain (GSAL), and also from early negative diastolic global strain rate (GSRE); reservoir function from the sum of GSA- and GSA1+ (SUMGSA), positive global strain rate at the beginning of LV systole (GSR+), and time from P to peak (TGSR+). Results: Active LA function (GSA-) was significantly lower, whereas passive and reservoir functions were significantly higher (GSA1+, GSA2+, GSAL, SUMGSA) with R-wave method (both p&lt;0.001; see table). There were no differences between methods regarding all derived times and strain rate indices. Conclusions: The 2 methods used to assess LA functions by STE do not provide similar results. The R-wave method essentially ignores active function, and overestimates late conduit function by comparison with the P-wave method, and therefore, we suggest that using P-wave as a reference point for generation of strain curves might estimate correctly all LA functions.
Abstract 3451: Prediction of Ischemic Mitral Regurgitation Recurrence after Ring Annuloplasty: A Transthoracic Echocardiography Approach
Authors: Jolanta K Biernat, Krzysztof S Golba, Marek A Deja, Kazimierz Widenka, Wojciech Domaradzki, Marek Jasinski, Anna-Maria Dalecka, Marcin Malinowski, Romuald Twardowski, Piotr Pysz, Stanislaw Wos
Journal: Circulation (2006)
Abstract 522: Specific Oxidized Phospholipids Modulate Platelet Reactivity In Vivo During Hyperlipidemia Via Cd36: A Mechanism Linking Hyperlipidemia, Oxidant Stress And A Pro-thrombotic Phenotype
Authors: Eugene A Podrez, Tatiana V Byzova, Maria Febbraio, Robert G Salomon, Yi Ma, Manojkumar Valiyaveettil, Eugenia Poliakov, Mingjiang Sun, Paula J Finton, Brian R Curtiss, Juhua Chen, Renliang Zhang, Roy L Silverstein, Stanley L Hazen
Journal: Circulation (2007)

Enhanced platelet reactivity is critical to the pathophysiology of occlusive arterial thrombotic disease. Despite the strong clinical associations between hyperlipidemia, a major risk factor for atherosclerosis, and a pro-thrombotic phenotype, the mechanisms responsible for enhanced platelet reactivity during hyperlipidemia remain unknown. Pro-atherosclerotic lipid abnormalities such as hypercholesterolemia are associated with both enhanced oxidant stress and generation of biologically active oxidized lipids, including potential ligands for the scavenger receptor CD36, a major platelet surface glycoprotein. Using multiple murine in vivo thrombosis models we now demonstrate that hyperlipidemic atherosclerosis prone mice (apolipoprotein E-deficient or LDL receptor-deficient) form occlusive intravascular thrombi faster than wildtype mice, and that genetic deletion of CD36 protects mice from hyperlipidemia-associated enhanced platelet reactivity and accompanying pro-thrombotic phenotype. Structurally defined oxidized choline glycerophospholipid molecular species that serve as endogenous high affinity ligands for CD36 are shown to : be markedly increased in plasma of hyperlipidemic mice; be elevated in plasma of subjects with low HDL levels; and to promote platelet activation and alpha-granule release via CD36 at pathophysiological levels. These studies thus demonstrate that platelet CD36 interactions with specific endogenous oxidized lipids play a heretofore unrecognized role in the well-known clinical associations between hyperlipidemia, oxidant stress and a prothrombotic phenotype.
Abstract 6057: Elevated LDL-Cholesterol Causes a Higher Exercise Blood Pressure Response
Authors: Daniel A Duprez, Natalia Florea, Jia Xu, Gregory A Grandits, Lynn Hoke, Jay N Cohn
Journal: Circulation (2008)

Background: Increased blood pressure (BP) response during exercise has been associated with an increased cardiovascular risk. It is unknown how LDL-cholesterol (LDL-c) is related to the exercise-induced BP response as well as to the large (LAE) and small artery (SAE) elasticity in subjects free from overt cardiovascular disease (CVD). We examined the relationship between serum LDL-c and the BP response during a moderate exercise treadmill test in subjects with no overt CVD and also the relationship between LDL-c and LAE and SAE. Methods: 1229 Subjects (700 male, 529 female) free of overt CVD were recruited during a CVD prevention screening program. A fasting venous blood sample was taken for LDL-cholesterol determination. LAE and SAE were derived from radial pulse wave contour analysis. Resting BP was measured. Then they performed a treadmill exercise test for 3 minutes at a 5 METS (metabolic equivalents) workload. Systolic and diastolic BP were measured at the peak of the 3 min exercise test, The study population was divided in quartiles among distribution of LDL-cholesterol (LDL-c). Results: Table 1 summarizes the results. There was no significant difference in large artery elasticity. Conclusions: In asymptomatic subjects, LDL-c is not related with resting BP. Higher LDL-c is related with higher exercise systolic BP response. This higher BP response can be explained by a lower smaller artery elasticity which is a marker for endothelial dysfunction probably related to higher LDL-c. Further studies to examine the effect of lipid-lowering therapy on exercise BP response are warranted Table 1
Folk healing: a description and synthesis
Authors: Robert C. Ness, Ronald M. Wintrob
Journal: American Journal of Psychiatry (1981)

All societies have developed ways of dealing with physical and mental illness, defined as folk healing systems. The authors review the systems of folk healing that have evolved in different cultural groups in the United States. They describe the faith healing practices of fundamentalist Christian groups, the belief in rootwork among white and black people in the southeastern United States, curanderismo among Mexican-Americans, and espiritismo among Americans from Puerto Rico. Most believers in folk healing also go to physicians for medical care. The authors argue that physicians should familiarize themselves with patients' folk healing beliefs in order to serve them more effectively.
Frequency of transformation to diffuse large B-cell lymphoma in nodular lymphocyte predominant hodgkin lymphoma: The BCCA Experience
Authors: M. M. Almansour, J. M. Connors, R. D. Gascoyne, B. Skinnider, K. J. Savage
Journal: Journal of Clinical Oncology (2008)

8566 Background: Nodular lymphocyte predominant Hodgkin Lymphoma (NLPHL) accounts for approximately 5% of all HL. Although the prognosis of patients of NPHL is typically excellent, previous observations have suggested that there is a higher risk of transformation to diffuse large B cell lymphoma (DLBCL) than in classical HL. However, in many studies, follow-up has been limited and this event can occur years later. We evaluated the frequency of transformation in all patients diagnosed with NLPHL at the British Columbia Cancer Agency (BCCA) over a 40 y period. Methods: The Lymphoid Cancer Database of the BCCA was searched to identify all patients with NLPHL between 1965 and 2006. 149 cases of NLPHL were identified; 4 were excluded due to composite pathology with DLBCL at diagnosis, leaving 145 cases for this analysis. Results: Cases of NLPHL had the following characteristics at diagnosis: median age 36 y; 72% male; 70% stage I /II; 10% B symptoms; 88% normal LDH; 92% PS of 0/1. Patients with limited stage disease received radiotherapy (RT) alone (56%) or chemotherapy ± RT (44%). Patients with advanced stage disease received MOPP-like or ABVD-like chemotherapy ± RT. With a median follow-up of 8.2 y (1.4 y- 38 y), 15 (10%) cases of transformation to DLBCL have occurred (12 DLBCL; 2 T-cell rich B-cell lymphoma; 1 unknown). The median age at transformation was 49 y (26 y-76 y), 13 (87%) were males, 14 (93%) had stage III/IV disease and 9 (60%) had an elevated LDH. Transformation was more likely in those with stage III/IV disease (p=.015), B symptoms (p=.007) or poor performance status (p=.025) at diagnosis. The median time to transformation to DLBCL was 9.9 years (.34y to 19.6 years). The risk of transformation to DLBCL at 10 y is 7% and the projected risk at 20 y is 22%. Conclusions: The risk of transformation in NLPHL to DLBCL is substantial and underappreciated. In this population-based study it was more often seen in patients with advanced stage, poor PS and B symptoms at diagnosis. Given that transformation can occur years after the primary diagnosis of LPHL, long-term follow-up of these individuals is necessary to accurately estimate the risk of development of secondary DLBCL. No significant financial relationships to disclose.
The application of mitotic activity and necrosis to lung adenocarcinoma and correlation with the Iaslc/ats/ers multidisciplinary classification of adenocarcinoma in stage 1 disease
Authors: E. E. Duhig, B. E. Clarke, D. Godbolt, A. Dettrick, J. Pauli, I. A. Yang, R. Bowman, K. M. Fong
Journal: Journal of Thoracic Oncology (2012)
Abstract 15457: Impact of the Novel Mobile Telemedicine System in Real-Time Transmission of Prehospital 12-Lead ECG for ST-Segment Elevation Acute Myocardial Infarction
Authors: Nobuhito Yagi, Takafumi Yamane, Taichi Adachi, Toshikazu Jinnai, Eiji Tada, Yoichiro Kasahara, Junichi Kotani, Hiroki Sakamoto, Hiroyuki Yokoyama, Hiroshi Nonogi
Journal: Circulation (2011)

Background: AHA/ACC guidelines recommend prehospital 12-lead ECG for patients with acute coronary syndromes (ACS). However, transmission of prehospital 12-lead ECG to emergency department (ED) is s...
Abstract MP024: Low Serum Vitamin D is Associated with Musculoskeletal Pain in Statin Users
Authors: Catherine Buettner, Travis Y Morioka
Journal: Circulation (2012)

Introduction: Statin use is associated with higher prevalence of self-reported musculoskeletal pain in the general population. Non-blinded studies have shown improvement in myalgia symptoms and increased tolerance to statin use after treatment of vitamin D deficiency. In this study, we hypothesized that lower serum vitamin D concentration would be associated with a higher odds of self-reported musculoskeletal pain among statin users. Methods: Using the National Health and Nutrition Examination Survey (NHANES) 2001–2004, we performed logistic regression to examine the association between vitamin D concentration and self-reported musculoskeletal pain and to evaluate if statin use modified the association. We evaluated vitamin D deficiency using a serum vitamin D concentration considered in the deficient range in clinical practice and representing the lowest quintile of vitamin D concentrations in the population studied (less than15 ng/mL). We adjusted for the effects of age, sex, race, smoking, BMI, physical activity, health status, peripheral vascular disease, coronary heart disease, diabetes, osteoporosis, arthritis, statin use and use of pain medications in logistic regression models. We also explored concentration-related trends of the effect of vitamin D on musculoskeletal pain. Results: Among 6217 participants age 40 years and older, the mean vitamin D concentration was 23.5 ng/mL (95%CI 22.4 ng/mL, 24.2 ng/mL). Statin medications were used by 17% of the participants in the last 30 days. Statin users had higher odds (aOR 1.6, 95%CI 1.2, 2.1) of self-reported musculoskeletal pain in any area (specifically including the lower extremities, lower back, upper extremities, and upper back) compared with non-users. Vitamin D deficiency was not a predictor of musculoskeletal pain (aOR 1.0, 95%CI 0.8, 1.3) in the overall sample. Among 1145 statin users, we found statin use modifies the effect of vitamin D deficiency on musculoskeletal pain (p for interaction = 0.02). Compared to statin users with a vitamin D concentration 15 ng/mL or higher, those with vitamin D concentration less than 15 ng/mL had higher odds of musculoskeletal pain (aOR 1.8, 95% CI 1.1, 3.1). We did not observe a concentration-related trend between increasing vitamin D concentrations and musculoskeletal pain (p for trend=0.7). Conclusion: In conclusion, after controlling for multiple confounders, a vitamin D concentration less than 15 ng/mL was not found to be associated with musculoskeletal pain in the overall sample in this population-based study. However, statin use modifies the relationship between vitamin D deficiency and musculoskeletal pain, such that a vitamin D concentration less than 15 ng/mL is associated with higher odds of self-reported musculoskeletal pain among statin users.
Abstract 2303: Prospective Correlation of Echocardiography Findings with Hematologic and Pulmonary Function Parameters in Children with Sickle Cell Disease
Authors: Niti Dham, Craig Sable, Caterina P Minnitti, Andrew Campbell, Manuel Arteta, Glenna Winnie, Sohail Rana, Deepika Darbari, Onyinye Oneykwere, Gregory J Kato, Mark T Gladwin, Oswaldo L Castro, Victor R Gordeuk, Gregory Ensing
Journal: Circulation (2007)

Background Adults with sickle cell disease (SCD) have an increased prevalence of pulmonary hypertension (PAH), associated with significant morbidity and mortality. This finding has not been validated in children. We carried out a prospective comparison of echocardiography (echo) data between SCD and control patients and a correlation between echo findings and hematologic and pulmonary function testing (PFT) in SCD patients. Methods Children with SCD and age and gender matched controls were prospectively enrolled during well visits. Each subject underwent a history and examination, echo, hematologic testing, and PFT. Echo data was compared between SCD patients and controls, and regression analysis was performed to assess for correlation between echo parameters and anemia, markers of hemolysis, and PFT in SCD patients. Results Of the 194 SCD patients and 29 controls enrolled, 180 SCD patients and 26 controls had measurable tricuspid valve regurgitation (TR) to estimate systolic pulmonary pressure. TR, left ventricle (LV) size and LV mass were significantly higher in children with SCD (Table 1 ). Linear regression analysis in SCD patients showed that TR, LV size, LV mass, and diastolic function (E/E TDI ) correlated significantly with hemoglobin, markers of hemolysis, and obstructive pulmonary disease (Table 2 ). There was no correlation between echo parameters and age, blood pressure, or measures of restrictive lung disease Conclusion Children with SCD have higher estimated pulmonary pressure, LV size and mass and a trend toward worse diastolic function when compared to controls. TR and LV size and mass correlate with anemia, hemolysis, and obstructive patterns on PFT. Table 1 - Comparative Data Table 2 - Regression Analysis
Abstract 1752: Cross-transplantation Studies Demonstrate the Role of Renal Dopamine D5 Receptors in Hypertension
Authors: Laureano D Asico, Xiaojie Zhang, Jifu Jiang, David Cabrera, Crisanto S Escano, Ines Armando, Yingjin Luo, David Sibley, Roslyn Mannon, Pedro A Jose
Journal: Circulation (2008)
The impact of audit and feedback on nodal harvest in colorectal cancer (CRC).
Authors: G. A. Porter, R. Urquhart, J. Bu, P. Johnson, E. Grunfeld
Journal: Journal of Clinical Oncology (2010)

6017 Background: Adequate nodal harvest (≥ 12 lymph nodes) in CRC has been shown to optimize staging and proposed as a quality indicator of CRC care. An audit of a single health authority (HA) in Nova Scotia (NS), presented and published in 2002, revealed that adequate nodal harvest occurred in only 22% of patients. The goal of this current study was to identify factors associated with adequate nodal harvest in the entire province of NS, and specifically to examine the impact of the audit and feedback strategy on nodal harvest. Methods: This population-based study included all patients undergoing resection for CRC in NS, Canada, from 1/1/2001-31/12/2005. Linkage of the provincial cancer registry with other databases (hospital discharge, physician billing, and national census) provided clinicodemographic, diagnostic, and treatment data. Factors associated with adequate nodal harvest were examined using multivariate logistic regression. The specific interaction between year and HA was examined to identify any potential effect of dissemination of the previously performed audit. Results: Among the 2,322 patients, the median nodal harvest was 7; overall, 719 (31%) had an adequate nodal harvest. The rate of adequate nodal harvest by year at both the audited and non-audited HAs is shown in the Table. On multivariate analysis, audited HA (p<0.0001), year (p<0.0001), younger age (p<0.001), nonemergent surgery (p=0.001), more advanced stage (p=0.008), and previous cancer history (p=0.03) were associated with an increased likelihood of an adequate nodal harvest. Interaction between year and audited HA was identified (p=0.006) such that the increase in adequate nodal harvest over time was significantly greater in the audited HA. Conclusions: Improvements in CRC nodal harvest did occur over time. A published audit demonstrating suboptimal nodal harvest appeared to be an effective tool, though more so for the audited HA, suggesting a potentially beneficial effect of audit and feedback strategies. Year N ≥ 12 lymph nodes (%) 2001 Audited HA 187 29.4 Nonaudited HAs 295 15.3 2002 Audited HA 157 35.0 Nonaudited HAs 294 20.4 2003 Audited HA 179 47.5 Nonaudited HAs 277 19.5 2004 Audited HA 149 60.4 Nonaudited HAs 325 27.7 2005 Audited HA 146 62.3 Nonaudited HAs 313 30.0 No significant financial relationships to disclose.
Cocaine-induced paranoia and psychosis proneness
Authors: S L Satel, W S Edell
Journal: American Journal of Psychiatry (1991)

The aim of this study was to determine whether individuals who experience transient cocaine-induced paranoia are vulnerable to psychosis.The subjects were 20 cocaine-dependent men who had been using more than 5 g of cocaine per week and were undergoing substance abuse treatment; half reported binge-limited cocaine-induced paranoia. The men were assessed with the Perceptual Aberration Scale and the Magical Ideation Scale, self-report measures of symptoms thought to precede the development of functional psychosis.The combined scores on the Perceptual Aberration Scale and Magical Ideation Scale were strongly correlated with a history of cocaine-induced paranoia. The sensitivity, specificity, and positive and negative predictive power were 80.0%, 90.0%, 88.9%, and 81.8%, respectively.Heavy cocaine users who experience transient paranoia while intoxicated may be at higher risk for development of psychosis than cocaine users who do not experience paranoia.
Abstract 17455: Pharmacodynamic Response to Clopidogrel in Men versus Women: Insights from the PRINCIPLE-TIMI 44 Trial
Authors: Amy Sarma, Stephen D Wiviott, Elliott Antman, Jessica L Mega, Sabina A Murphy, Elaine Hoffman, Marc S Sabatine, Michelle L O'Donoghue
Journal: Circulation (2012)

Background: Concerns have been raised regarding the relative efficacy and safety of antiplatelet drugs in women. It remains unknown whether women achieve similar levels of platelet inhibition with ...
Abstract 2777: Optimal Expansion of the Stent is a Major Contributor to the Neointimal Coverage Following Sirolimus-eluting Stent Implantation: A Combined Study of Angioscopy and Intravascular Ultrasound
Authors: Fusako Sera, Jun-ichi Kotani, Masaki Awata, Shinsuke Nanto, Masaaki Uematsu, Takakazu Morozumi, Tetsuya Watanabe, Toshinari Onishi, Osamu Iida, Hitoshi Minamiguchi, Hirokuni Akahori, Masamichi Yano, Kuniyasu Ikeoka, Shin Okamoto, Nobuaki Tanaka, Haruyo Yasui, Seiki Nagata
Journal: Circulation (2007)

Background: Although sirolimus-eluting stent (SES) has significantly reduced in-stent restenosis by inhibiting neointimal hyperplasia, insufficient neointimal coverage after stenting may result in adverse outcomes. Determinants of neointimal coverage following SES, however, are poorly understood. Methods: We evaluated 28 SES lesions using both angioscopy and intravascular ultrasound (IVUS). Degree of neointimal coverage was judged by angioscopy at follow-up (11 ± 6 months): complete/incomplete coverage, based on whether the stent struts were embedded by the neointima. Minimal stent area (MSA), external elastic membrane (EEM), lumen cross-sectional area (CSA) and plaque burden (EEM minus lumen/EEM CSA) were measured by IVUS at stent implantation. Both proximal and distal references were used. Stent expansion was assessed by stent expansion index (SEI) as MSA/reference EEM CSA. Under-expansion was defined as SEI &lt; 0.4. Incomplete apposition was defined as the lack of contact between any strut and the underlying vessel wall. Results: Complete coverage was identified in 10 (36%), and incomplete coverage in 18 (64%). Time from the stenting to angioscopy (10 ± 5 versus 11 ± 7 months, p=0.8) as well as the lesion and procedural characteristics was similar between the complete/incomplete coverage groups. IVUS parameters were also similar, except for the final MSA (7.0±1.8mm 2 in complete versus 5.3±1.9mm 2 in incomplete , p=0.02) and lumen CSA at the distal reference site (6.1±1.4mm 2 in complete versus 4.9 ±1.2mm 2 in incomplete , p= 0.02). The frequency of incomplete apposition was similar between the groups (20% in complete versus 39% in incomplete , P= 0.4); however, SEI was significantly larger in the complete coverage than in the incomplete coverage group (0.52 ± 0.11 versus 0.39 ± 0.09, p=0.002). Stent under-expansion was identified only in 2 (20%) of the complete coverage, as compared to 67% of the incomplete coverage group (P=0.046). By multivariate logistic regression analysis, large SEI was strongly associated with complete neointimal coverage (P=0.04). Conclusion: Optimal expansion of the stent is a major contributor to the complete neointimal coverage following sirolimus-eluting stent implantation.
Two-year follow-up of exposure and imipramine treatment of agoraphobia
Authors: Matig Mavissakalian, Larry Michelson
Journal: American Journal of Psychiatry (1986)

Sixty-two agoraphobic patient who had completed a controlled study of therapist-assisted in vivo exposure (flooding) and imipramine were assessed 1 month, 6 months, 1 year, and 2 years later. Overall, improvement during treatment was maintained throughout follow-up. At 1 month but not subsequently, imipramine and flooding had significant effects on central measures of agoraphobia. Patients who were marked treatment responders had a favorable clinical course and did not experience secondary depression, unlike patients who had not responded markedly to treatment. These findings suggest that treatments which evoke maximum therapeutic benefit initially are likely to foster long-term maintenance and reduce subsequent depressive sequelae.