ADRENAL HORMONE THERAPY IN VIRAL HEPATITIS. III. THE EFFECT OF ACTH AND CORTISONE IN SEVERE AND FULMINANT CASES
Authors: Alfred S. Evans, Helmuth Sprinz, Robert S. Nelson
Journal: Annals of Internal Medicine (1953)

Article1 June 1953ADRENAL HORMONE THERAPY IN VIRAL HEPATITIS. III. THE EFFECT OF ACTH AND CORTISONE IN SEVERE AND FULMINANT CASESALFRED S. EVANS, HELMUTH SPRINZ, ROBERT S. NELSONALFRED S. EVANSSearch for more papers by this author, HELMUTH SPRINZSearch for more papers by this author, ROBERT S. NELSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-6-1148 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe present study is concerned with the results of ACTH and cortisone therapy in 11 severe cases of viral hepatitis that had not responded to conservative measures, six of whom ultimately died. The six fatal cases represent the mortality from some 1,500 cases of hepatitis admitted during the period of this investigation. Our decision to treat such patients with adrenal hormone therapy was influenced in part by our results in early acute viral hepatitis,1-4‡and in part by a discouraging previous experience with this type of case using only supportive measures.5Reports from other clinics of the beneficial, often dramatic...Bibliography1. ColbertHollandHeisslerKnowlton JWJAIM: The use of ACTH in acute viral hepatitis, New England J. Med. 245: 172-176 (Aug. ) 1951. CrossrefMedlineGoogle Scholar2. EvansSprinzNelson ASHRS: Adrenal hormone therapy in viral hepatitis. I. The effect of ACTH in the acute disease, Ann. Int. Med. 38: 1115-1133, 1953. LinkGoogle Scholar3. EvansSprinzNelson ASHRS: Adrenal hormone therapy in viral hepatitis. II. The effect of cortisone in the acute disease, Ann. Int. Med. 38: 1134-1147, 1953. LinkGoogle Scholar4. EichmanHavensMiller PLWPRW: The effect of ACTH and cortisone on the concentration of circulating antibody in patients with acute hepatitis, to be published. Google Scholar5. SwiftGardnerMooreStreitfieldHavens WEHTDJFHWP: Clinical course of viral hepatitis and the effect of exercise during convalescence, Am. J. Med. 8: 614-622, 1950. CrossrefMedlineGoogle Scholar6. RifkinMarksHammermanBlumenthalWeissWeingarten HLJDJMJAB: Use of corticotropin and cortisone in acute homologous serum hepatitis, Arch. Int. Med. 89: 32-40 (Jan.) 1952. CrossrefGoogle Scholar7. DucciKatz HR: Cortisone, ACTH and antibiotics in fulminant hepatitis, Gastroenterology 21: 357-374, 1952. CrossrefMedlineGoogle Scholar8. Wildhirt E: Zur Behandlung des schweren akuten Leberparenchymschadens, Med. Welt 20: 941-943, 1951. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 11, 1953.From the Hepatitis Center, 98th General Hospital, U. S. Army, Europe.†Present address: Department of Preventive Medicine and Student Health, University of Wisconsin, School of Medicine, Madison, Wisconsin.‡The experience of this center in this form of therapy includes five cases treated by Colbert et al.,1 four cases included in a report by Eichman et al.,4 30 acute cases treated in controlled studies by us,2, 3 two cases as yet unreported, and the 11 severe cases in the present paper, one of whom was treated in consultation at another Army hospital because he was too ill to be transferred here. 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LIPSCHUTZ, M.D., F.A.C.P., DAVID CAPSON, M.D.Adrenal hormone therapy in viral hepatitisTreatment of Acute Hepatitis With Cortisone and AntibioticsLebererkrankungen im KindesalterCholeretic Action of Cortisone 1 June 1953Volume 38, Issue 6Page: 1148-1159KeywordsAdrenocorticotropic hormoneClinical decision support systemsHepatitisHepatitis DHepatitis EHormonal therapyHormonesMortalityPreventive medicineSurgeons ePublished: 1 December 2008 Issue Published: 1 June 1953 PDF downloadLoading ...