tbuckley/cabot-search huggingface dataset:
New Introductory Lectures on Psycho-Analysis
Authors: A. J. Lewis
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ticagrelor Versus Prasugrel in Acute Coronary Syndrome Patients With High On-Clopidogrel Platelet Reactivity Following Percutaneous Coronary Intervention
Authors: Dimitrios Alexopoulos, Anastasia Galati, Ioanna Xanthopoulou, Eleni Mavronasiou, George Kassimis, Konstantinos C. Theodoropoulos, George Makris, Anastasia Damelou, Grigorios Tsigkas, George Hahalis, Periklis Davlouros
Journal: Journal of the American College of Cardiology (2012)
Risk of cancer and exposure to power lines
Authors: A. Philips
Journal: BMJ (1994)

work on the evaluation of many traditional reme- dies.To proceed further, however, evidence is needed to confirm or refute what seems to be common sense, as well as to measure the size of any problem.In Walsall, we are conducting a descriptive study into the use of complementary and traditional therapies by ethnic groups and the reasons for their use.We will be looking particu- larly at the Asian community, but, given the diversity of available therapies used by this group, the task will not be straightforward.At least a study of this nature may help us to gauge its importance.Who knows, it may even be appro- priate for some health authorities to consider purchasing some types of alternative or comple- mentary medicine.
Hypoparathyroidism
Authors: Dolores Shoback
Journal: New England Journal of Medicine (2008)

A 58-year-old man is found on laboratory testing to have a serum calcium level of 6.0 mg per deciliter (normal range, 8.5 to 10.5), an albumin level of 3.9 g per deciliter, and a phosphorus level of 6.0 mg per deciliter (normal range, 2.5 to 4.5). His medical history is notable only for long-standing hearing difficulties. He reports no history of neck surgery and is asymptomatic. His ionized calcium level is 0.75 mmol per liter (normal range, 1.10 to 1.32). How should his case be further evaluated and treated?
Abstract 1994: Anemia and Chronic Kidney Disease (CKD) are powerful predictors for Presence and Severity of Coronary Artery Disease (CAD)
Authors: Jeffrey R Cook, Abdul Hakeem, Sabha Bhatti, Eric M Williams, Su Min Chang
Journal: Circulation (2006)

BACKGROUND: Patients (pts) with chronic kidney disease (CKD) carry a higher risk of cardiovascular disease. Whether anemia confers a higher risk is less studied.

OBJECTIVE: This study sought to ascertain whether CAD as determined by myocardial perfusion imaging is more common among pts with anemia (Hb: Hemoglobin   13 g/l) and CKD (GFR: glomerular filtration rate ≤ 60 ml/min/1.73 Kg/m2)

METHOD: A total of 1580 pts ( mean age 65 + −10 y/o, 43% diabetics) with suspected CAD underwent clinical, ECG, laboratory evaluation and gated myocardial perfusion SPECT. Patients were divided into 4 groups according to their Hb and GFR. (1: No Anemia/No CKD n = 800, 2: CKD/No anemia n = 332, 3: Anemia/No CKD n = 195, 4: Anemia and CKD n = 253).

RESULTS: Compared to group of pts with normal Hb and GFR, myocardial perfusion defect is more common in those with anemia and CKD. (Group 1: 48%, Group 2: 65%, Group 3: 59 %, Group 4: 72%, al P < 0.05) Patients with CKD and anemia also exhibited a more severe coronary heart disease (mean summed stress score: SSS 6.5 + − 4 vs. 4.5 + −7 P < 0.01) In addition, the prevalence of high-riskscan findings predictive of worse prognosis (SSS ≥ 8, transient ischemic dilation, or left ventricular ejection fraction ≤ 40%) was also higher in pts with anemia and CKD than those with normal Hb and GFR (Group 1: 28 %, Group 2: 38%, Group 3: 38%, Group 4: 48 %, al P < 0.05) After adjusting for clinical and ECG information, anemia and CKD are associated with a higher risk of perfusion defect and high-risk scan. The association was stronger among those with combined anemia and CKD. (See table[⇓][1])

CONCLUSION: Both anemia and CKD are independent predictor of coronary heart disease. Pts with both anemia and CKD were almost twice more likely to have high risk CAD than those with normal Hb and renal function.



![Table][2]  [1]: #T1
 [2]: pending:yes
Abstract 16822: Magnetic Resonance Imaging Based Signal Intensity Mapping Predicts Appropriate Therapies After Prophylactic Ventricular Tachycardia Substrate Ablation in Patients With Previous Myocardial Infarction and Secondary Prevention Implantable Cardioverter-Defibrillator Implantation
Authors: Loreto Bravo, Angel Arenal, Esther Perez-David, Pablo Avila, Antonio Rojas, Felipe Atienza, Esteban Gonzalez-Torrecilla, Tomas Datino, Maria Ledesma-Carbayo, Gerard Loughlin, Bermejo Javier, Francisco Fernandez-Aviles
Journal: Circulation (2013)

Background: Prophylactic ventricular tachycardia substrate ablation (PVTSA) reduces the rate of appropriate therapies in secondary prevention ICD patients. Scar characteristics assessed by contrast...
Ectopic Goiter Masquerading as Submandibular Gland Swelling
Authors: RAKESH KUMAR, SANJAY SHARMA, ATUL MARWAH, DENISH MOORTHY, DINESH DHANWAL, ARUN MALHOTRA
Journal: Clinical Nuclear Medicine (2001)

Ectopic thyroid glands generally occur in the midline as a result of abnormal median migration, and their presence lateral to the midline is rare. A 12-year-old boy had a swelling in the left submandibular region that imaging techniques showed to be an ectopic thyroid gland, although no thyroid tissue was seen in the normal location. Only eight cases of lateral aberrant thyroid tissue have been reported. The importance of being aware of the possibility of ectopic thyroid tissue as a submandibular region swelling has an important bearing on disease management. A pertinent review of the literature and its management is included.
Abstract 1162: avb3-Integrin-targeted Paramagnetic Nanoparticles Deliver Rapamycin into the Vascular Wall and Inhibit Stenosis Following Balloon Injury
Authors: Tillmann Cyrus, Shelton D Caruthers, John S Allen, Todd A Williams, Ralph W Fuhrhop, Thomas D Harris, Samuel A Wickline, Gregory M Lanza
Journal: Circulation (2006)
Enzymatic and Metabolic Studies with Allopurinol
Authors: G. B. Elion
Journal: Annals of the Rheumatic Diseases (1966)

2 The Ki for allopurinol was erroneously reported earlier (Elion and others, 1964) to be 4-4 x 10-9M.6081 The value for Km reported by Watts, Watts, and Seegmiller (1965) for human intestinal xanthine oxidase, Km = 1-55 x 10-M, is in good agreement with those reported here, since their studies were carried out at pH 8 *3 (pyrophosphate buffer, 37' C.).Their value falls between those found at pH 8 *0 and pH 8 * 6 for the human liver enzyme (see Table ).
Abstract 2652: Primary Angioplasty And Thrombolysis For ST Elevation Myocardial Infarction Result In Similar Left Ventricular Function And Rates Of Inducible Ventricular Tachycardia.
Authors: James J Chong, Anand N Gannesan, Vickie Eipper, Pramesh Kovoor
Journal: Circulation (2007)

Introduction/Hypothesis. Electrophysiological studies (EPS) predict risk of sudden death after myocardial infarction. Primary angioplasty has become the preferred method of treatment for STEMI due to improved patency rates of the infarct related artery, along with decreased rates of reinfarction and death. Despite this, intravenous thrombolysis remains the first line treatment in 30 –70% of cases worldwide. We assessed the hypothesis that the left ventricular ejection fraction (LVEF) and rates of inducible VT would be more favorable in patients treated with primary angioplasty compared to thrombolysis. Methods/Results. Consecutive patients receiving primary angioplasty (n=225) or thrombolysis (n=195) for STEMI were included. Mean LVEF assessed predominantly by gated blood heart pool scan was 47.7 ±12.1% for the primary angioplasty group and 46.3 ±13.0% for the thrombolysis group (p=0.30). The proportion of patients with LVEF less than 40% was 29.7% in the primary angioplasty group and 29.6% in the thrombolysis group (p=0.98). Patients with LVEF less than 40% underwent EPS. VT was inducible in 10% of patients who had primary angioplasty versus 11% of patients who had thrombolysis (p=0.69). Mean cycle length (CL) of inducible VT in milliseconds (ms) was 246 ± 48 for the angioplasty group and 261 ± 62 for thrombolysis group (p=0.65). Implantable cardiac defibrillators were inserted in 30 patients of which 8 (27%) had appropriate device activations. The mean time from infarction to first spontaneous activation was 387 ± 458 days. Mean CL of spontaneous VT was 314 ± 62 ms. Conclusions. In conclusion patients treated with thrombolysis or primary angioplasty for STEMI are likely to have similar resultant left ventricular function and rates of inducible ventricular tachycardia. There was a surprisingly high rate of spontaneous defibrillator activations often occurring late after myocardial infarction. Table 1: Patient and treatment characteristics for each group.
Abstract 2008: The prospective, randomised IABP SHOCK Trial - Hemodynamic Effects of Intraaortic Balloon Counterpulsation in Patients With Acute Myocardial Infarction complicated by Cardiogenic Shock
Authors: Michael Buerke, Roland Prondzinsky, Henning Lemm, Michael Sweyter, Nicolas Wegener, Susanne Unverzagt, Justin Carter, Martin Russ, Karl Werdan
Journal: Circulation (2007)

Objectives: Intraaortic balloon pump (IABP) counterpulsation is part of the treatment in patients with cardiogenic shock complicating myocardial infarction. It is used to improve cardiac function, reduce peripheral resistance, and augment coronary, cerebral and renal flow. However, there is only limited prospective randomized data for the efficacy of IABP treatment in these patients. Therefore we conducted the IABP Shock Trial as a prospective, randomized, monocentric clinical trial, to determine the hemodynamic effects of additional IABP treatment in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock.  Methods. Cardiac catheterization was performed in 40 patients with acute myocardial infarction complicated by cardiogenic shock, within 12 h of onset of hemodynamic instability. Serial hemodynamic parameters were determined over the next 4 days and compared to patients receiving only medical treatment and those treated with additional intraaortic counterpulsation.  Results. In the medically treated group (no IABP) serial cardiac output documented a -significant increase from day 0 to day 4 (from 4.9 ± 0.3 l/min to 6.7 ± 0.7 l/min). Similar was the rise of cardiac output in patients treated with IABP (from 4.7 ± 0.4 l/min to 6.3 ± 0.4 l/min). However, there was no significant difference between both groups. Pulmonary capillary wedge pressure showed no significant reduction over time and there was no significant difference between both groups. Systemic vascular resistance (SVR) decreased in both groups but did not significantly differ. Further, we were unable to demonstrate a significant differences in cardiac power (CP) for both treatments of the 96 hour period.  Conclusions. Additional IABP treatment did not result in a significant hemodynamic improvement compared to medical therapy alone. Interestingly, even the prognosis validated cardiac power did not show any significant difference. Nevertheless, IABP treatment did not show any harm. Our hemodynamic results have to be validated in a larger prospective randomized trial.
Abstract 1636: Adverse Effect of Estrogen on Bone Morphogenetic Protein Receptor Signal Pathway in Pulmonary Arterial Endothelial Cells
Authors: Hiroaki Ichimori, Shigetoyo Kogaki, Hidekazu Ishida, Jun Narita, Toshiki Uchikawa, Sayaka Nasuno, Yoko Okada, Keiichi Ozono
Journal: Circulation (2008)

Gender differences in the development of Pulmonary Artery Hypertension (PAH) have been documented in both human and animal studies. In human, idiopathic PAH is predominantly a disease of young women in their child-bearing years, which suggests a role of female sex hormones in the pathogenesis of PAH. However, the effect of sex hormones on pulmonary vasculatures and the development of PAH has not been fully understood. Recent researches have revealed genetic predisposition such as BMPR (Bone Morphogenetic Protein Receptor). The aim of the present study is to investigate the effect of β-estradiol (E2) and oxygen concentration upon BMPR signal pathway in pulmonary arterial endothelial cells (PAEC) in vitro. Human and rat PAEC were cultured and we examined the expression of BMPR2, BMP-regulated Smads, and Id1 under 21% or 1% O 2 with BMP2 stimulation. Then, we investigate changes in the expression of these molecules in the presence of E2 with or without estrogen receptor antagonist (ICI 182.780.). First, we confirmed that estrogen receptor α and β were expressed in both PAECs. Second, we demonstrated that the expression of mRNA transcripts for BMPR2 and Id1 in PAEC was reduced after exposure to 24 hours’ hypoxia. In addition, E2 decreased the expression of phosphorylated Smad (p-Smad)1/5/8 in a dose-dependent manner (10 −10 M-10 −7 M) and p-Smad1/5/8 expression were decreased about 80% by 10 −7 M of E2. These attenuation of p-Smad1/5/8 expression were rescued by ICI182.780. Third, under normoxic condition with cobalt chloride or deferoxamine to prevent the degradation of HIF (hypoxia-inducible factor)-1α, the presence of E2 decreased the expression of p-Smad1/5/8 like under hypoxia. Conversely, administration of HIF-1α inhibitor (YC-1) canceled the reduced expression of p-Smad1/5/8 like under normoxia. Under hypoxia, the presence of E2 attenuates the BMPR signal pathway in PAEC in vitro. Our data indicated that the advance effect of E2 on BMPR signal pathway was associated with HIF-1α and estrogen receptor. Our observations provide the first evidence that female sex hormone affects on BMPR signal pathway, which can offer new strategies for the treatment of PAH.
Abstract 3403: Mechanisms of Nkx2–5 Dependent Left-Right Asymmetry of the Cardiac Crescent
Authors: Cindy M Martin, Yi Ren, Arianna Caprioli, MIchael Kyba, Richard P Harvey, Daniel J Garry
Journal: Circulation (2008)

Previous studies have defined a role for Nodal, Cripto and Pitx2c in left-right (LR) asymmetry. The transcriptional patterning of the cardiac crescent has not been previously described. We have engineered and utilized a 6 kb Nkx2–5-EYFP transgenic mouse that directs reporter expression in cardiac progenitors and combinatorially mated them into the wildtype (WT) or Nkx2–5 mutant backgrounds. Staged embryos were bisected, cardiac progenitors were collected using FACS and the signature of gene expression of cardiac progenitors that populate the left vs. the right regions of the cardiac crescent were examined. We observed that the left side of the WT cardiac crescent had increased expression of Nodal, Cripto and Pitx2 transcripts that are known to have functions critical to future chamber myocardium as well as Nkx2–5. The right side of the crescent was not enriched for a specific gene program however enrichment was noted for Hoxa9 and Hoxa10. We analyzed the same LR transcriptional program in the Nkx2–5 mutan...
The course of geriatric depression with "reversible dementia": a controlled study
Authors: G S Alexopoulos, B S Meyers, R C Young, S Mattis, T Kakuma
Journal: American Journal of Psychiatry (1993)

The goals of this longitudinal investigation were 1) to study the rate of development of irreversible dementia in elderly depressed patients with a dementia syndrome that subsided after improvement of depression and 2) to compare it with that of depressed, never-demented patients.The subjects were 57 elderly patients consecutively hospitalized for major depression. At entry into the study, 23 subjects also met criteria for "reversible dementia," while 34 were without dementia. After a systematic clinical evaluation, the subjects were followed up at approximately yearly intervals for an average of 33.8 months.Irreversible dementia developed significantly more frequently in the depressed group with reversible dementia (43%) than in the group with depression alone (12%). Survival analysis showed that the group with reversible dementia had a 4.69-times higher chance of having developed dementia at follow-up than the patients with depression alone. No clinical characteristics at entry into the study were found to discriminate the subjects who developed irreversible dementia during the follow-up period from those who remained nondemented.These findings suggest that geriatric depression with reversible dementia is a clinical entity that includes a group of patients with early-stage dementing disorders. Therefore, identification of a reversible dementia syndrome is an indication for a thorough diagnostic workup and frequent follow-ups in order to identify treatable neurological disorders.
Serum Ferritin Level As a Prognostic Marker For Peripheral T-Cell Lymphoma.
Authors: Satoshi Koyama, Naoto Tomita, Reina Watanabe, Megumi Itabashi, Daisuke Ishibashi, Yoshimi Ishii, Yukako Hattori, Yuki Nakajima, Kenji Motohashi, Hirotaka Takasaki, Rika Kawasaki, Chizuko Hashimoto, Hideyuki Koharazawa, Sachiya Takemura, Rika Sakai, Shin Fujisawa, Shigeki Motomura, Yoshiaki Ishigatsubo
Journal: Blood (2013)
Polarity therapy and cancer-related fatigue
Authors: J. A. Roscoe, S. E. Matteson, G. R. Morrow, A. Shelke
Journal: Journal of Clinical Oncology (2004)

8147 Background: Cancer and its treatment produces fatigue in a majority of patients. Despite the very high prevalence of this problem, no effective treatments are available. Increasing numbers of cancer patients are turning to complementary and alternative medicine practices to find relief. We examined the efficacy of Polarity Therapy (PT), a massage-like intervention classified by NCCAM as an “energy therapy,” in relieving fatigue in female breast cancer patients receiving radiation therapy. Methods: 15 Patients (mean age = 52.5) were randomly assigned to one of three trial groups. Arm 1 patients did not receive any (PT). Patients assigned to Arm 2 received a PT tx on a Tuesday during their 4th week of radiation treatment. Patients assigned to Arm 3 received PT on Tuesdays during \(\underline{\mathrm{both}}\) their 4th and 5th weeks of radiation treatment. Patients completed the Brief Fatigue Inventory (BFI) during the 3rd through 5th weeks of radiation treatment. Each PT session lasted 60–75 minutes with the patient lying fully clothed on a massage table while the same experienced, licensed Polarity Therapist administered all PT treatments. Results: Change scores on the BFI from baseline showed a statistically significant improvement in fatigue in the 10 patients who had PT compared to the 5 patients who did not after the first week (mean change score: one PT tx = 1.0, SD = 1.46; no PT = −0.6, SD = .93; p = .05). Eight of the ten patients showed an improvement in fatigue following their first PT treatment, while only one of five patients in the control group had an improvement in fatigue during the same time frame. A one-way analysis of variance (ANOVA) examining group differences the following week closely approached conventional levels of statistical significance (mean change score: two PT tx = 2.2, SD = 1.03; one PT tx = 1.6, SD = 1.10; no PT = 0.6, SD = .87; p = .08. A significant (p = .03) linear contrast suggested a possible dose effect. Conclusions: This pilot supports a confirmatory trial of Polarity Therapy for cancer- related fatigue. No significant financial relationships to disclose.
Abstract 3714: Heme Oxygenase 1 Determines the Outcome of Vulnerable Plaque
Authors: Annemarie M Noordeloos, Caroline Cheng, M L Simoons, G Pasterkamp, H J Duckers
Journal: Circulation (2008)

Plaque vulnerability is an important determinant in the prognosis of CAD. However the mechanism of transition from stable to vulnerable plaque (VP) remains unclear. Heme oxygenase 1 (HO-1) and its metabolites of heme degradation have been implicated in the cytoprotective defense response against oxidative injury. Here, we sought to assess the role of HO-1 in the development of VP in carotid artery disease in human and in a mouse model of VP. Atherectomy biopsies of 109 patients with clinical significant CAD were collected and stratified according to plaque morphology. HO-1 protein expression was determined by ELISA and was correlated with plaque parameters and pro-inflammatory biomarkers.To evaluate the function of HO-1 in VP, HO-1 was induced by CoPPIX injections in a murine model for VP in APOE −/− mice. HO-1 expression correlated closely to characteristics of atheromatous plaque vulnerability (p&lt; 0.005) as indicated by intimal macrophage and lipid accumulation, and inverse correlations coincided with VSMCs and collagen. HO-1 expression levels correlated with proinflammatory biomarker titers including intraplaque MMP9 and IL-8 and IL6. HO-1 was mainly expressed in atheromatous infiltrating macrophages. In line with these observations, HO-1 expression was significantly increased in the VP vs. the stable lesions in our murine VP model. Systemic CoPPIX injections in the murine model resulted in an effective five-fold increase at HO-1 protein level. HO-1 induction did not affect the intima/media ratio, nor the percentage of intimal collagen or macrophages in the intima. However, systemic HO-1 induction significantly increased the percentage of intraplaque VSMCs by two-fold, while decreasing the percentage of lipids by two-fold. HO-1 protein expression closely correlated with histomorphological atherosclerotic plaque vulnerability and with expression levels of MMPs and pro-inflammatory cytokines in CAD patients. HO-1 induction in the murine VP model stabilized plaque morphology by reducing lipid accumulation and increasing VSMCs contect in these lesions. These data indicate that HO-1 expression in VP vs. stable plaques is enhanced as a compensatory atheroprotective response.
AIDS in the Nervous System
Authors: Richard Lechtenberg, Joanna Hollenberg Sher
Journal: Annals of Internal Medicine (1988)

Part 1 The character of AIDS: immunodeficiency and the nervous system signs and symptoms of nervous system disease the basis for the Acquired Immune Deficiency Syndrome diagnosing AIDS evolving definitions of AIDS. Part 2 Epidemiology: high risk groups mechanisms for transmission geographic distribution. Part 3 Neurologic involvement: early signs of AIDS neurologic signs of HIV infection muscle disease cerebrovascular complications. Part 4 Opportunistic infections: taxoplasmosis cytomegalovirus herpes simplex fungi progressive multifocal leukoencephalopathy nocardia other infections concurrent infections. Part 5 Tumors: primary lymphomas metastatic lymphomas Kaposi's sarcoma other tumours. Part 6 Neurologic disease in infants and children: acqusition of AIDS sources of diagnostic confusion signs and symptoms of AIDS prognosis neuropathologic features sociologic aspects. Part 7 Treatment and prevention: investigation of AIDS patients management of systemic disease treatment of neurologic complications antiviral agents counselling prevention vaccination prognosis.