tbuckley/cabot-search huggingface dataset:
Lineage-dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and independent immunotherapeutic targets
Authors: Nathan M Kendsersky, Michal Odrobina, Nathaniel W Mabe, Alvin Farrel, Liron Grossmann, Matthew Tsang, David Groff, Adam J Wolpaw, Alaa Narch, Francesca Zammarchi, Patrick H van Berkel, Chi V Dang, Yaël P Mossé, Kimberly Stegmaier, John M Maris
Journal: Neuro-Oncology (2025)

Abstract Background Neuroblastoma is a heterogeneous disease with adrenergic (ADRN)- and therapy resistant mesenchymal (MES)-like cells driven by distinct transcription factor networks. Here, we investigate the expression of immunotherapeutic targets in each neuroblastoma subtype and propose pan-neuroblastoma and cell state specific targetable cell-surface proteins. Methods We characterized cell lines, patient-derived xenografts, and patient samples as ADRN-dominant or MES-dominant to define subtype-specific and pan-neuroblastoma gene sets. Targets were validated with ChIP-sequencing, immunoblotting, and flow cytometry in neuroblastoma cell lines and isogenic ADRN-to-MES transition cell line models. Finally, we evaluated the activity of MES-specific agents in vivo and in vitro. Results Most immunotherapeutic targets being developed for neuroblastoma showed significantly higher expression in the ADRN subtype with limited expression in MES-like tumor cells. In contrast, CD276 (B7-H3) and L1CAM maintained expression across both ADRN and MES states. We identified several receptor tyrosine kinases (RTKs) enriched in MES-dominant samples and showed that AXL targeting with ADCT-601 was potently cytotoxic in MES-dominant cell lines and showed specific anti-tumor activity in a MES cell line-derived xenograft. Conclusions Immunotherapeutic strategies for neuroblastoma must address the potential of epigenetic downregulation of antigen density as a mechanism for immune evasion. We identified several RTKs as candidate MES-specific immunotherapeutic target proteins for the elimination of therapy-resistant cells. We hypothesize that the phenomena of immune escape will be less likely when targeting pan-neuroblastoma cell surface proteins such as B7-H3 and L1CAM, and/or dual targeting strategies that consider both the ADRN- and MES-cell states.
A single-arm, phase II study of sotorasib plus carboplatin/pemetrexed in advanced non-squamous non-small cell lung cancer patients with KRAS G12C mutation (WJOG14821L, SCARLET)
Authors: Hiroaki Akamatsu, Shinya Sakata, Koichi Azuma, Hiroshige Yoshioka, Takehiro Uemura, Yuko Tsuchiya-Kawano, Seiya Esumi, Takashi Kurosaki, Yuki Sato, Tomohiro Sakamoto, Kiichiro Ninomiya, Ryo Toyozawa, Yasuto Yoneshima, Takehito Shukuya, Toshiyuki Kozuki, Kana Watanabe, Haruko Daga, Terufumi Kato, Toshiaki Takahashi, Mitsuo Osuga, Yasuhiro Koh, Satoshi Morita, Nobuyuki Yamamoto
Journal: Journal of Thoracic Oncology (2025)
Stress CMR VS Stress Echo: Real-world multimodal cardiovascular imaging for myocardial ischemia screening. Insights from the first phase of “Nancy Ischemia Registry”
Authors: Zukaï Chati
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

In a real world, the impact of different functional and anatomical imaging techniques is not really known. Objectives “Nancy Ischemia Registry” is a prospective registry, without inclusion or exclusion criteria, which analyzes the respective real impact and consequences of different functional and anatomical imaging techniques on major adverse cardiovascular events. In a “first phase”, we compared two functional imaging techniques used in our center: Stress CMR and Stress Echo. Materials &amp; Methods We consecutively included 169 patients in whom we performed Stress CMR and 687 patients in whom we performed Stress Echo. Results We detected myocardial ischemia in 59 patients by Stress CMR (35% of patients) and in 123 patients by Stress Echo (18% of patients). Coronary angiography confirmed at least one significant lesion in 54 patients in the Stress CMR group (PPV 91%) and in 90 patients in the Stress Echo group (PPV 73%). In patients with at least one significant coronary lesion, coronary angioplasty was performed in 38 patients (64% of true positives) in the Stress CMR group versus 64 patients in the Stress Echo group (71 % of true positives). Conclusion Stress CMR has a better specificity than Stress Echo for the detection of myocardial ischemia. However, detection of myocardial ischemia by Stress Echo more often leads to coronary revascularization than by Stress CMR. This difference in this register is probably explained by a higher sensitivity of the Stress CMR for the detection of myocardial ischemia linked to less severe lesions, whereas the Stress Echo mainly detects more severe lesions.
Once Again about the Main Cause of Atherosclerosis
Authors: Vladimir Ivanovich Ermoshkin
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

Annotation. The article is devoted to the most important topic in medicine: the causes of atherosclerosis. It seems that over the past 200 years, thousands of prominent scientists have approached this problem from different angles, and by today all ideas for possible causes have already been exhausted. But no,
Interdisciplinary Perspectives on Dentistry and Chest Pain: Bridging the Gap Between Dental and Cardiovascular Health
Authors: Ashish Pandey
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

Chest pain is a common symptom that can be indicative of a range of conditions, from benign to life-threatening. While traditionally associated with cardiovascular issues, recent research suggests a complex interplay between dental health and chest pain. This article explores the interrelationship between dental conditions and cardiovascular symptoms, focusing on the latest findings in the field. It examines how periodontal disease, dental infections, and oral hygiene practices might influence cardiovascular health and contribute to chest pain. By integrating recent advancements in diagnostic techniques and treatment modalities, this review highlights the importance of a multidisciplinary approach in managing patients with chest pain and dental issues.
New objectives drawn up by the Cuban Journal of Angiology and Vascular Surgery
Authors: Jose Ignacio Fernandez Montequin
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

Reviewing a magnificent article by Cuban scientists, as well as a report from the Cuban Academy of Sciences from January 2018, (1,2) I found some data that I reflect in this document to serve as a basis for the message I want to convey to my colleagues, friends, professors, and angiologists and vascular surgeons in training.
A framework towards implementation of sequencing for antimicrobial-resistant and other health-care-associated pathogens
Authors: Alison Laufer Halpin, Amy J Mathers, Timothy R Walsh, Walter Zingg, Iruka N Okeke, L Clifford McDonald, Christopher A Elkins, Stephan Harbarth, Sharon J Peacock, Arjun Srinivasan, Michael Bell, Didier Pittet, Denise Cardo
Journal: The Lancet Infectious Diseases (2025)
Global linear accelerator requirements and personalised country recommendations: a cross-sectional, population-based study
Authors: Fabio Y Moraes, Andre G Gouveia, Vanessa Freitas Bratti, Edward C Dee, Juliana Fernandes Pavoni, Laura M Carson, Cecília Félix Penido Mendes de Sousa, Richard Sullivan, Gustavo Nader Marta, Wilma M Hopman, Christopher M Booth, Ajay Aggarwal, Ahmedin Jemal, Timothy P Hanna, Brooke E Wilson, Gustavo Arruda Viani
Journal: The Lancet Oncology (2025)
Impact of Patient Empowerment on the Progression of Acute Coronary Syndrome: Development of the Methodology for a Case-Control Study
Authors: Gómez Barriga Maria Dolores
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

Background/Aim: Cardiovascular diseases, especially Acute Coronary Syndrome (ACS), are a growing global concern. The management of ACS relies on both medical treatment and patient empowerment to reduce readmissions and emergency room visits. This study focuses on identifying factors that limit patient empowerment. The article develops the methodology to assess the impact of empowerment on ACS patients through comprehensive follow-up. Materials and Methods: The study employs a systematic design to evaluate the impact of patient empowerment on ACS management over a 12-month follow-up period. Educational tools are integrated during hospitalization and post-discharge, with an initial assessment of patient knowledge and self-care conducted through standardized questionnaires and interviews. The nursing team, with cardiology expertise, oversees personalized interventions and collaborates with cardiologists to manage complications. Results: Results are pending analysis. This article details the methodology for tracking patient empowerment. Future publications will present the analysis of initial evaluations and the effectiveness of educational tools. Data is expected to reveal how educational strategies during and after hospitalization impact patient empowerment and ACS clinical outcomes. Discussion y/o Conclusions: Discussion will occur after results are available. The analysis is expected to explore how patient empowerment relates to reduced readmissions and emergency visits, and how initial assessments and educational tools address patient knowledge and self-care. Conclusions will be drawn from the results and presented in future publications. The study aims to show that integrating educational tools and proactive nursing follow-up can significantly enhance patient empowerment in ACS. Continued collaboration with cardiologists and personalized interventions will be essential for success.
Enhancing lesion detection in automated breast ultrasound using unsupervised multi-view contrastive learning with 3D DETR
Authors: Xing Tao, Yan Cao, Yanhui Jiang, Xiaoxi Wu, Dan Yan, Wen Xue, Shulian Zhuang, Xin Yang, Ruobing Huang, Jianxing Zhang, Dong Ni
Journal: Medical Image Analysis (2025)
Post Covid-19 War Era, Patients Protection Strategies Revisited
Authors: Bahram Alamdary Badlou
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

In the 21st Century, manufacturing synthetic Antigens, Immunogens, and Allergens (SAIAs) and are becoming a kind of booming business with(out) the Artificial Inelegance (AI)-based-accelerated propaganda, disastrously. These kinds of Medical Engineering are tackling frequently Medicare and Medicaid of patients, chronically. Because of induced pandemic attacks, more than 30 million subjects died from manufactured SAIAs i.e. Cardiovascular and Cancer patients who were (not) infected with COVID-19 mutants, Influenza viruses in the last 5 years, and counting. More than 65 million patients are suffering from 200 symptoms of longcovids’ clinical / pathophysiological side effects/ collateral damages, separately.
Vulnerable Plaque: What the Future Holds?
Authors: Rohit Mody
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

Background: The concept of vulnerable plaque has gained prominence over the past four decades. Extensive research into the pathophysiology of these plaques has been quite beneficial in assessing an individual susceptibility to cardiovascular events. Understanding the occurrence of cardiovascular events is crucial. Main Body: Vulnerable Plaque rupture along with plaque erosion contribute to acute coronary syndrome in over half of patients. The primary objective of this discussion is to demonstrate recent research findings on various diagnostic methods for the early detection, prevention, and treatment of patients at high risk of developing vulnerable plaques. Current studies and research are focused on various future imaging techniques that can detect this specific plaque pathophysiology. Identifying patients prone to vulnerability and implementing more intensive treatments for coronary atherosclerosis are key areas of ongoing investigation. Short conclusion: Plaques which are more vulnerable to rupture causing MACE can be identified with the evolution of new non-imaging and imaging modalities to prevent risk of CAD.
Cell ring-like objects created in agar cultures of synthetic DNA (Streptomyces) crown cells with monolaurin
Authors: Shoshi Inooka
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

Synthesized DNA crown cells (artificial cells), which can proliferate within egg white in vivo, can be prepared in vitro using sphingosine (Sph)-DNA-adenosine-monolaurin compounds. Synthesized DNA crown cells form assemblies that proliferate in the presence of monolaurin and can be observed in agar cultures. In previous experiments on synthetic DNA (E. coli/Human placenta/Ascidian) crown cells, the proliferation of objects similar in appearance to thalli, double-cells, morning glory and daffodil inflorescences was observed on agar plates. In the present experiments using synthetic DNA (Streptomyces) crown cells and monolaurin, various objects and examples of cell proliferation were observed on the agar plates. Here, the microscopic appearance of cell ring-like objects is described.
<i>Limosilactobacillus reuteri</i> - a probiotic gut commensal with contextual impact on immunity
Authors: Amanda H. Lee, Daphne Michelle Rodriguez Jimenez, Marlies Meisel
Journal: Gut Microbes (2025)

The gut microbiome plays a key role in human health, influencing various biological processes and disease outcomes. The historical roots of probiotics are traced back to Nobel Laureate Élie Metchnikoff, who linked the longevity of Bulgarian villagers to their consumption of sour milk fermented by Lactobacilli. His pioneering work led to the global recognition of probiotics as beneficial supplements, now a multibillion-dollar industry. Modern probiotics have been extensively studied for their immunomodulatory effects. Limosilactobacillus reuteri (L. reuteri), a widely used probiotic, has garnered significant attention for its systemic immune-regulatory properties, particularly in relation to autoimmunity and cancer. This review delves into the role of L. reuteri in modulating immune responses, with a focus on its impact on systemic diseases.
Angina with Non-obstructed Coronary Arteries and Invasive Diagnostic Testing in the Cardiac Catheterization Laboratory
Authors: J. Dawn Abbott
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

More than a third of patients who present to the cardiac catheterization laboratory for elective coronary angiography for a chronic coronary syndrome are found to have normal or nonobstructive coronary artery disease. Angina or ischemia with non-obstructive coronary arteries (ANOCA/ INOCA) is prognostically important and is associated with decreased quality of life and increasedcardiovascular morbidity. Chronic coronary syndromes are mediated by atherosclerosis, microvascular disease, and vasospastic disease at the epicardial and microvascular level. The severity of epicardial coronary disease is routinely evaluated with angiography and coronary physiology. A comprehensive invasive diagnostic assessment, however, is rarely pursued in patients determined to have non-obstructive coronary disease. In the modern cardiac catheterization laboratory, patients with ANOCA should be examined with flow assessment, intracoronary imaging, coronary flow reserve, microvascular resistance, and provocative testing to diagnose the mechanism of ischemia. Patients may have one or more endotypes including microvascular angina, microvascular spasm, or vasospastic angina with normal or non-obstructive coronary artery disease. This review provides an overview of the pathophysiology and catheterization lab invasive diagnostic testing that can guide the diagnosis and management of patients with ANOCA and discusses ongoing clinical trials.
The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery
Authors: Marcelo Flávio Gomes Jardim Filho
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

Cardiovascular and cancer pathologies represent significant causes of global morbidity and mortality. This systematic review investigates the safety and effectiveness of maintaining anticoagulant therapy in cardiac patients undergoing oncological surgery. Conducted between 2018 and 2023 following PRISMA guidelines, the review includes 10 prospective studies detailing the impact of anticoagulant use in the surgical context. Among the 2345 patients analyzed, the majority were men, primarily using low molecular weight heparin and warfarin. The results indicate that continuing anticoagulants does not significantly increase bleeding risks or postoperative complications, while interruption may elevate the risk of thromboembolic events. It is concluded that the decision to continue or interrupt anticoagulant treatment should be personalized based on a careful evaluation of individual risk.
Screening for Peripheral Artery Disease by Measuring the Ankle-Brachial Index in Patients Hospitalised in a Cardiology Department in Dakar, Senegal
Authors: Aliou Alassane Ngaide
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

University Cheikh Anta Diop of Dakar, Faculty of Medicine / Cardiology Department, Dalal Jamm Hospital, Guédiawaye, Senegal.
A Common 5bp (CTTCT) Deletion Polymorphism in TNNT2 is Significantly Associated with Hypertrophic Cardiomyopathy
Authors: Deepa Selvi Rani
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

Troponin T is a component of the Troponin complex, which plays a major role in the regulation of myocardial contraction in response to changes in the intracellular Ca2+ion concentration. Deletion of 5bp (CTTCT) in the polypyrimidine tract of intron 3 of the cardiac Troponin T gene (TNNT2) results in cTnT2 and cTnT4 isoforms by skipping of exon 4, which was reported to be associated with hypertrophic cardiomyopathy (HCM). In the present study, we screened a common 5bp deletion polymorphism in TNNT2 gene using direct sequencing in 178 cardiomyopathy patients with significant LV hypertrophy from North India against 197 ethnically matched and clinically well-characterized healthy controls. Our study revealed a high frequency of del/del genotype in patients with HCM vs controls (p=0.000007). The deletion and insertion allele frequencies in patients and controls were (75% &amp; 25%) and (56% &amp; 44%), respectively. Further, analysis of 2056 caste and tribe groups belonging to highly diverse endogamous people inhabited in different states of India have revealed higher deletion allele frequency in both South and North Indian states compare to control group whereas the North-eastern states showed a slightly higher frequency of insertion allele. In conclusion, the deletion allele frequency in the HCM patient group is found to be significantly higher than the control group (p=&lt;.0001). Therefore, the deletion allele frequency is not only associated with LV hypertrophy in Japanese, French, and South Indian HCM patients but also in North Indian HCM patients.
Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients
Authors: Gómez Barriga Maria Dolores
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

Background/Aim: Acute Coronary Syndrome (ACS) remains a significant cause of morbidity and mortality worldwide. Cardiovascular disease (CVD) prevention remains crucial despite advancements in clinical outcomes. Empowering patients with self-care skills is essential for managing ACS, and digital tools can enhance these practices. This study qualitatively evaluates patients' experiences with post-ACS digital tools to improve self-care. Material and methods: A qualitative phenomenological approach was employed, utilizing in-depth interviews with patients diagnosed with ACS enrolled in a telephonic follow-up program. Sampling continued until saturation was reached. Data collection included patients' perceptions of the accessibility and utility of digital tools in enhancing self-care knowledge. A descriptive analysis of age and gender was conducted to analyze potential demographic influences. Results: Ninety patients participated, with males predominating (70%) and a mean age of 69.2 years. Patients reported positive engagement with both educational videos and health blogs. Preferences varied, with 54% favoring videos and 36% preferring blogs. Difficulties in accessing digital tools were observed, especially among elderly patients. However, patients emphasized the instrumental role of these tools in complementing knowledge and facilitating self-care, while recognizing the irreplaceable value of direct interaction with healthcare professionals. Conclusions: Future interventions should focus on improving digital tools accessibility and effectively integrating them into patient care pathways to optimize self-care outcomes.
Substance Use is Associated with Increased Readmissions, But Not In-hospital Morbidity or “Long-term” survival After Left Ventricular Assist Device Implantation
Authors: Aurelie Merlo
Journal: Clinical Cardiology and Cardiovascular Interventions (2024)

Aim: Patients with active substance use are not eligible for heart transplantation and often undergo left ventricular assist device (LVAD) implantation. We define substance use as use of a substance that precludes transplant such as tobacco products, marijuana, illicit drug use, and excessive alcohol use. The purpose of this study is to describe and compare outcomes in patients with active or recent substance use undergoing LVAD implantation to those who do not use substances. Materials and Methods: We performed a single-center retrospective cohort study of all patients undergoing HeartMate3 implantation during the period from 2017 to 2023. The patients were divided into those who have a current or recent history of substance use (SUD) and those who do not. The primary outcome was survival. And the secondary outcome measures included in-hospital outcomes and readmission rate. The Kaplan Meier method was used to calculate overall survival. An unadjusted multivariate cox proportion hazards model was used to assess differences in survival. Adjusted Poisson regression models were used to determine differences in readmission rates. Results: 177 patients were included, with 55 (31%) of patients using substances at the time of implantation (mainly tobacco products and marijuana). Patients using substances were younger (p&lt;0.001) and had a higher body mass index (p=0.012). Survival (HR 1.51, CI (0.84-2.71)) and in-hospital outcomes were not significantly different between groups (stroke, bleeding, renal failure, days in intensive care, length of stay, mortality). When adjusting for age and INTERMACS score, patients with SUD had significantly higher rates of readmissions compared to those without SUD (IRR: 1.23, 95% CI:1.02-1.50, p=0.035). Conclusions: In conclusion, in a large single-center retrospective cohort study, patients who are using substances at the time of LVAD implantation have the same survival and in-hospital complication rates as patients who are not using substances. When adjusting for age and INTERMACS score, patients who use substances have a higher readmission rate than patients who are not using substances.
Computational frameworks transform antagonism to synergy in optimizing combination therapies
Authors: Jinghong Chen, Anqi Lin, Aimin Jiang, Chang Qi, Zaoqu Liu, Quan Cheng, Shuofeng Yuan, Peng Luo
Journal: npj Digital Medicine (2025)

While drug combinations are increasingly important in disease treatment, predicting their therapeutic interactions remains challenging. This review systematically analyzes computational methods for predicting drug combination effects through multi-omics data integration. We comprehensively assess key algorithms including DrugComboRanker and AuDNNsynergy, and evaluate integration approaches encompassing kernel regression and graph networks. The review elucidates artificial intelligence applications in predicting drug synergistic and antagonistic effects.