tbuckley/cabot-search huggingface dataset:
Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua
Authors: Yael Alippe, Leran Wang, Reyan Coskun, Stéfanie P. Muraro, Fang R. Zhao, Michelle Elam-Noll, J. Michael White, Daiana M. Vota, Vanesa C. Hauk, Jeffrey I. Gordon, Scott A. Handley, Michael S. Diamond
Journal: The Journal of Experimental Medicine (2024)

The contribution of placental immune responses to congenital Zika virus (ZIKV) syndrome remains poorly understood. Here, we leveraged a mouse model of ZIKV infection to identify mechanisms of innate immune restriction exclusively in the fetal compartment of the placenta. ZIKV principally infected mononuclear trophoblasts in the junctional zone, which was limited by mitochondrial antiviral-signaling protein (MAVS) and type I interferon (IFN) signaling mechanisms. Single nuclear RNA sequencing revealed MAVS-dependent expression of IFN-stimulated genes (ISGs) in spongiotrophoblasts but not in other placental cells that use alternate pathways to induce ISGs. ZIKV infection of Ifnar1-/- or Mavs-/- placentas was associated with greater infection of the adjacent immunocompetent decidua, and heterozygous Mavs+/- or Ifnar1+/- dams carrying immunodeficient fetuses sustained greater maternal viremia and tissue infection than dams carrying wild-type fetuses. Thus, MAVS-IFN signaling in the fetus restricts ZIKV infection in junctional zone trophoblasts, which modulates dissemination and outcome for both the fetus and the pregnant mother.
Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis
Authors: Bethan L. Thomas, Trinidad Montero‐Melendez, Silvia Oggero, Magdalena K. Kaneva, David Chambers, Andreia L. Pinto, Alessandra Nerviani, Davide Lucchesi, Shani Austin‐Williams, Mohammed T. Hussain, Costantino Pitzalis, Benjamin Allen, Marzia Malcangio, Francesco Dell'Accio, Lucy V. Norling, Mauro Perretti
Journal: Arthritis & Rheumatology (2024)

Objective This study was undertaken to establish the potential therapeutic profile of neutrophil‐derived extracellular vesicles (EVs) in experimental inflammatory arthritis and associate pharmacological activity with specific EV components, focusing on microRNAs. Methods Neutrophil EVs were administered intra‐articularly through a prophylactic or therapeutic protocol to male C57BL/6 mice undergoing serum‐transfer–induced inflammatory arthritis. Transcriptomic analysis of knees was performed on joints following EV administration, naive and arthritic mice (untreated; n = 4/group) and EV‐treated diseased mice (intra‐articular administration) with contralateral (vehicle‐treated; n = 8/group). Comparison of healthy donor and patients with rheumatoid arthritis (RA) neutrophil EVs was performed. Results EVs afforded cartilage protection with an increase in collagen‐II and reduced collagen‐X expression within the joint. To gain mechanistic insights, RNA sequencing of the arthritic joints was conducted. A total of 5,231 genes were differentially expressed ( P &lt; 0.05), with 257 unique to EV treatment. EVs affected key regenerative pathways involved in joint development, including Wnt and Notch signaling. This wealth of genomic alteration prompted to identify microRNAs in EVs, 10 of which are associated with RA. As a proof of concept, we focused on miR‐455‐3p, which was detected in both healthy donor and RA EVs. EV addition to chondrocyte cultures elevated miR‐455‐3p and exerted anticatabolic effects upon interleukin‐1β stimulation; these effects were blocked by actinomycin or miR‐455‐3p antagomir. Conclusion Neutrophils from patients with RA yielded EVs with composition, efficacy, and miR‐455‐3p content similar to those of healthy volunteers, suggesting that neutrophil EVs could be developed as an autologous treatment to protect and repair joint tissue of patients affected by inflammatory arthritides. image
Effectiveness of nirsevimab against RSV-bronchiolitis in paediatric ambulatory care: a test-negative case–control study
Authors: Yannis Lassoued, Corinne Levy, Andreas Werner, Zein Assad, Stephane Bechet, Bruno Frandji, Christophe Batard, Aurélie Sellam, Fabienne Cahn-Sellem, Inès Fafi, Léa Lenglart, Camile Aupiais, Romain Basmaci, Robert Cohen, Naim Ouldali
Journal: The Lancet Regional Health - Europe (2024)

Respiratory syncytial virus (RSV) is the leading cause of lower-respiratory-tract infection in children. Nirsevimab, a monoclonal antibody against RSV, was implemented in a few countries in September 2023. However, its post-license effectiveness in ambulatory care settings is unknown. We aimed to assess the effectiveness of nirsevimab against RSV-bronchiolitis in outpatients aged <12 months.
Correction: A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development
Authors: Shan Liu, Jie Zhou, Xiangling Ye, Danni Chen, Weimin Chen, Yaobin Lin, Zhizhong Chen, Biyun Chen, Jin Shang
Journal: Leukemia (2024)
An NAD+-dependent metabolic checkpoint regulates hematopoietic stem cell activation and aging
Authors: Zehan Song, Sang Hee Park, Wei-Chieh Mu, Yufan Feng, Chih-Ling Wang, Yifei Wang, Marine Barthez, Ayane Maruichi, Jiayue Guo, Fanghan Yang, Anita Wong Lin, Kartoosh Heydari, Claudia C S Chini, Eduardo N Chini, Cholsoon Jang, Danica Chen
Journal: Nature Aging (2024)
Hidden flaws behind expert-level accuracy of multimodal GPT-4 vision in medicine
Authors: Qiao Jin, Fangyuan Chen, Yiliang Zhou, Ziyang Xu, Justin M. Cheung, Robert Chen, Ronald M. Summers, Justin F. Rousseau, Peiyun Ni, Marc J. Landsman, Sally L. Baxter, Subhi J. Al’Aref, Yijia Li, Alexander Chen, Josef A. Brejt, Michael F. Chiang, Yifan Peng, Zhiyong Lu
Journal: npj Digital Medicine (2024)

Abstract Recent studies indicate that Generative Pre-trained Transformer 4 with Vision (GPT-4V) outperforms human physicians in medical challenge tasks. However, these evaluations primarily focused on the accuracy of multi-choice questions alone. Our study extends the current scope by conducting a comprehensive analysis of GPT-4V’s rationales of image comprehension, recall of medical knowledge, and step-by-step multimodal reasoning when solving New England Journal of Medicine (NEJM) Image Challenges—an imaging quiz designed to test the knowledge and diagnostic capabilities of medical professionals. Evaluation results confirmed that GPT-4V performs comparatively to human physicians regarding multi-choice accuracy (81.6% vs. 77.8%). GPT-4V also performs well in cases where physicians incorrectly answer, with over 78% accuracy. However, we discovered that GPT-4V frequently presents flawed rationales in cases where it makes the correct final choices (35.5%), most prominent in image comprehension (27.2%). Regardless of GPT-4V’s high accuracy in multi-choice questions, our findings emphasize the necessity for further in-depth evaluations of its rationales before integrating such multimodal AI models into clinical workflows.
Targeting the glucocorticoid receptor-CCR8 axis mediated bone marrow T cell sequestration enhances infiltration of anti-tumor T cells in intracranial cancers
Authors: Jia Zhang, Yuzhu Shi, Xiaotong Xue, Wenqing Bu, Yanan Li, Tingting Yang, Lijuan Cao, Jiankai Fang, Peishan Li, Yongjing Chen, Zhen Li, Changshun Shao, Yufang Shi
Journal: Cellular and Molecular Immunology (2024)
SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice
Authors: Justin H. Berger, Timothy R. Matsuura, Caitlyn E. Bowman, Renee Taing, Jiten Patel, Ling Lai, Teresa C. Leone, Jeffrey D. Reagan, Saptarsi M. Haldar, Zoltan Arany, Daniel P. Kelly
Journal: Circulation Research (2024)
Advances in sickle cell retinopathy screening techniques, tests, and practices: A systematic review
Authors: Olivia W. Cummings, Sara Rahman, Lauren Fletcher, Adrienne W. Scott
Journal: American Journal of Hematology (2024)

Sickle cell retinopathy (SCR) is a progressive, sight-threatening ophthalmic complication of sickle cell disease (SCD). Current SCR screening focuses on the detection of pathologic sea fan neovascularization, the first sign of proliferative sickle cell retinopathy (PSR). If untreated, PSR can lead to severe visual impairment and blindness through progression to vitreous hemorrhage and/or retinal detachment. SCR screening with dilated fundus examination (DFE) is recommended every 1-2 years starting at age 10, but data underlying this recommendation are of poor quality and based upon expert consensus. We performed a systematic review to characterize imaging techniques, laboratory-based tests, and clinical practices for SCR screening. This PROSPERO-registered systematic review included relevant texts identified through predetermined searches in online databases. Collected test accuracy data facilitated the calculation of likelihood ratios. Forty-four studies evaluating 4928 patients were included. DFE demonstrated moderate test accuracy (LR+ of 8.0, LR- of 0.3). Ultra-widefield-fundus photography demonstrated superior accuracy (LR+ 32.5, LR- 0.03). Optical coherence tomography angiography applications were highly accurate for PSR identification (machine learning LR+ 32.5, LR- 0.03; human grader LR+ 2.8-213.1, LR- 0.1-0.2). Most techniques and tests were more accurate at detecting PSR than staging SCR or detecting lower-grade SCR. Our findings support the integration of advanced image-based approaches, such as computer-based image analysis and ultra-wide-field fundus imaging, for SCR screening in SCD patients given the superior accuracy in PSR detection compared with the current standard of care. Rigorous SCR screening implementation studies are needed to support evidence-based SCR screening recommendations.
Antibacterial Agents and Adjuvants against Pseudomonas Aeruginosa Infections
Authors: Yuwei Zheng, Jiaying Chi, Jiayu Ou, Ling Jiang, Liqing Wang, Rui Luo, Yilang Yan, Zejun Xu, Tingting Peng, Jianfeng Cai, Chuanbin Wu, Peng Teng, Guilan Quan, Chao Lu
Journal: Advanced Healthcare Materials (2024)

Abstract The development of narrow‐spectrum antimicrobial agents is paramount for swiftly eradicating pathogenic bacteria, mitigating the onset of drug resistance, and preserving the homeostasis of bacterial microbiota in tissues. Owing to the limited affinity between the hydrophobic lipid bilayer interior of bacterial cells and most hydrophilic, polar peptides, the construction of a distinctive class of four‐armed host‐defense peptides/peptidomimetics (HDPs) is proposed with enhanced specificity and membrane perturbation capability against Pseudomonas aeruginosa by incorporating imidazole groups. These groups demonstrate substantial affinity for unsaturated phospholipids, which are predominantly expressed in the cell membrane of P. aeruginosa , thereby enabling HDPs to exhibit narrow‐spectrum activity against this bacterium. Computational simulations and experimental investigations have corroborated that the imidazole‐rich, four‐armed peptidomimetics exhibit notable selectivity toward bacteria over mammalian cells. Among them, 4H10, characterized by its abundant and densely distributed imidazole groups, exhibits impressive activity against various clinically isolated P. aeruginosa strains. Moreover, 4H10 has demonstrated potential as an antibiotic adjuvant, enhancing doxycycline accumulation and exerting effects on intracellular targets by efficiently disrupting bacterial cell membranes. Consequently, the hydrogel composed of 4H10 and doxycycline emerged as a promising topical agent, significantly diminishing the skin P. aeruginosa burden by 97.1% within 2 days while inducing minimal local and systemic toxicity.
The contribution of intimate partner violence to vertical HIV transmission: a modelling analysis of 46 African countries
Authors: Salome Kuchukhidze, Magdalene K Walters, Dimitra Panagiotoglou, Marie-Claude Boily, Souleymane Diabaté, W Alton Russell, Heidi Stöckl, Lynnmarie Sardinha, Francisco Mbofana, Rhoda K Wanyenze, Jeffrey W Imai-Eaton, Mathieu Maheu-Giroux
Journal: The Lancet HIV (2024)
Redirecting Tumor Evolution with Nanocompiler Precision for Enhanced Therapeutic Outcomes
Authors: Wenshe Sun, Biao Cai, Zejun Zhao, Shilun Li, Yutian He, Shaowei Xie
Journal: Advanced Healthcare Materials (2024)

Abstract Precisely programming the highly plastic tumor expression profile to render it devoid of drug resistance and metastatic potential presents immense challenges. Here, a transformative nanocompiler designed to reprogram and stabilize the mutable state of tumor cells is introduced. This nanocompiler features a trio of components: 2‐deoxy‐ d ‐glucose‐modified lipid nanoparticles to inhibit glucose uptake, iron oxide nanoparticles to induce oxidative stress, and a deubiquitinase inhibitor to block adaptive protein profile changes in tumor cells. By specifically targeting the hypermetabolic nature of tumors, this approach disrupted their energy production, ultimately fostering a state of vulnerability and impeding their ability to adapt and resist. The results of this study indicate a substantial reduction in tumor growth and metastasis, thus demonstrating the potential of this strategy to manipulate tumor protein expression and fate. This proactive nanocompiler approach promises to steer cancer therapy toward more effective and lasting outcomes.
Smart Response Biomaterials for Pain Management
Authors: Xinyu Zhang, Mengtong Guan, Weiwei Yi, Xinhe Li, Xiaoqian Ding, Yi He, Wang Han, Zijie Wang, Qiuyu Tang, Bo Liao, Jieliang Shen, Xiaoyu Han, Dingqun Bai
Journal: Advanced Healthcare Materials (2024)

The intricate nature of pain classification and mechanism constantly affects the recovery of diseases and the well-being of patients. Key medical challenges persist in devising effective pain management strategies. Therefore, a comprehensive review of relevant methods and research advancements in pain management is conducted. This overview covers the main categorization of pain and its developmental mechanism, followed by a review of pertinent research and techniques for managing pain. These techniques include commonly prescribed medications, invasive procedures, and noninvasive physical therapy methods used in rehabilitation medicine. Additionally, for the first time, a systematic summary of the utilization of responsive biomaterials in pain management is provided, encompassing their response to physical stimuli such as ultrasound, magnetic fields, electric fields, light, and temperature, as well as changes in the physiological environment like reactive oxygen species (ROS) and pH. Even though the application of responsive biomaterials in pain management remains limited and at a fundamental level, recent years have seen the examination and debate of relevant research findings. These profound discussions aim to provide trends and directions for future research in pain management.
Nanotechnology‐Mediated Immunomodulation Strategy for Inflammation Resolution
Authors: Ying Li, Wen Liu, Yuanchao Wang, Taotao Liu, Yakai Feng
Journal: Advanced Healthcare Materials (2024)

Abstract Inflammation serves as a common characteristic across a wide range of diseases and plays a vital role in maintaining homeostasis. Inflammation can lead to tissue damage and the onset of inflammatory diseases. Although significant progress is made in anti‐inflammation in recent years, the current clinical approaches mainly rely on the systemic administration of corticosteroids and antibiotics, which only provide short‐term relief. Recently, immunomodulatory approaches have emerged as promising strategies for facilitating the resolution of inflammation. Especially, the advanced nanosystems with unique biocompatibility and multifunctionality have provided an ideal platform for immunomodulation. In this review, the pathophysiology of inflammation and current therapeutic strategies are summarized. It is mainly focused on the nanomedicines that modulate the inflammatory signaling pathways, inflammatory cells, oxidative stress, and inflammation targeting. Finally, the challenges and opportunities of nanomaterials in addressing inflammation are also discussed. The nanotechnology‐mediated immunomodulation will open a new treatment strategy for inflammation therapy.
Regenerating Chemotherapeutics through Copper‐Based Nanomedicine: Disrupting Protein Homeostasis for Enhanced Tumor Therapy
Authors: Xubo Wu, Qinghe Wu, Mengfei Hou, Yifei Jiang, Meng Li, Guoping Jia, Huizhen Yang, Chunfu Zhang
Journal: Advanced Healthcare Materials (2024)

The bis-(diethyldithiocarbamate)-copper (CuET), the disulfiram (DSF)-Cu complex, has exhibited noteworthy anti-tumor property. However, its efficacy is compromised due to the inadequate oxidative conditions and the limitation of bioavailable copper. Because CuET can inactivate valosin-containing protein (VCP), a bioinformatic pan-cancer analysis of VCP is first conducted in this study to identify CuET as a promising anticancer drug for diverse cancer types. Then, based on the drug action mechanism, a nanocomposite of CuET and copper oxide (CuO) is designed and fabricated utilizing bovine serum albumin (BSA) as the template (denoted as CuET-CuO@BSA, CCB). CCB manifests peroxidase (POD)-mimicking activity to oxidize the tumor endogenous H
Effective response to upadacitinib in patients affected by prurigo nodularis and by atopic dermatitis with a predominant prurigo nodularis pattern: A multicenter case series study
Authors: Elena Pezzolo, Alessandra Narcisi, Luigi Gargiulo, Vito Di Lernia, Maddalena Napolitano, Cataldo Patruno, Simone Ribero, Michela Ortoncelli, Caterina Foti, Paolo Romita, Carlotta Gurioli, Donatella Schena, Silvia Mariel Ferrucci, Francesca Barei, Giuseppe Fabrizio Amoruso, Filomena Russo, Luigi Naldi
Journal: Journal of the American Academy of Dermatology (2024)
Decellularized Amnion Membrane Triggers Macrophage Polarization for Desired Host Immune Response
Authors: Tong Zhang, Mingfei Shao, Hanfeng Li, Xin Chen, Ruiying Zhang, Jingwen Wu, Jianing Wang, Yanchuan Guo
Journal: Advanced Healthcare Materials (2024)

Appropriate regulation of immunomodulatory responses, particularly acute inflammation involving macrophages, is crucial for the desired functionality of implants. Decellularized amnion membrane (DAM) is produced by removing cellular components and antigenicity, expected to reduce immunogenicity and the risk of inflammation. Despite the potential of DAM as biomaterial implants, few studies have investigated its specific effects on immunomodulation. Here, it is demonstrated that DAM can regulate macrophage-driven inflammatory response and potential mechanisms are investigated. In vitro results show that DAM significantly inhibits M1 polarization in LPS-induced macrophages by inhibiting Toll-like receptors (TLR) signaling pathway and TNF signaling pathway and promotes macrophage M2 polarization. Physical signals from the 3D micro-structure and the active protein, DCN, binding to key targets may play roles in the process. In the subcutaneous implant model in rats, DAM inhibits the persistence of inflammation and fibrous capsule formation, while promoting M2 macrophage polarization, thereby facilitating tissue regeneration. This study provides insights into DAM's effect and potential mechanisms on the balance of M1/M2 macrophage polarization in vitro and vivo, emphasizing the immunomodulation of ECM-based materials as promising implants.
Efficacy of TIL Therapy in Advanced Cutaneous Melanoma in the Current Immuno-oncology Era: Updated Systematic Review and Meta-analysis
Authors: S Martín-Lluesma, I M Svane, U Dafni, K Vervita, D Karlis, G Dimopoulou, Z Tsourti, M W Rohaan, J B A G Haanen, G Coukos
Journal: Annals of Oncology (2024)
Classification Criteria for Axial Disease in Youth With Juvenile Spondyloarthritis
Authors: Pamela F. Weiss, Timothy G. Brandon, Amita Aggarwal, Ruben Burgos‐Vargas, Robert A. Colbert, Gerd Horneff, Ronald M. Laxer, Kirsten Minden, Angelo Ravelli, Nicolino Ruperto, Judith A. Smith, Matthew L. Stoll, Shirley M. Tse, Filip Van den Bosch, Walter P. Maksymowych, Robert G. Lambert, David M. Biko, Nancy A. Chauvin, Michael L. Francavilla, Jacob L. Jaremko, Nele Herregods, Ozgur Kasapcopur, Mehmet Yildiz, Hemalatha Srinivasalu, Daniel J. Lovell, Peter A. Nigrovic, Ivan Foeldvari, Marisa S. Klein‐Gitelman, Seza Ozen, Ray Naden, Alison M. Hendry, Rik Joos
Journal: Arthritis & Rheumatology (2024)

The goal was to develop and validate classification criteria for axial juvenile spondyloarthritis (SpA; AxJSpA).
Impact of a school-based food assistance program on household food insecurity in Greece, 2012–2019: a multi-year evaluation of the DIATROFI program
Authors: Dimitrios V Diamantis, Athena Linos, Frank B Hu, Afroditi Veloudaki, Athanassios Petralias, Cindy W Leung
Journal: The Lancet Regional Health - Europe (2024)

Childhood food insecurity can persist among low socioeconomic areas in high-income countries. Universal Free School Meal (UFSM) programs are designed to respond to this pressing issue. This study aimed to conduct a multi-year evaluation of the DIATROFI Program's impact on household food insecurity in Greece.
Supplemental vitamin D on trial: no evidence of benefit as an adjuvant treatment for melanoma
Authors: Remco van Doorn
Journal: British Journal of Dermatology (2024)

Journal Article Corrected proof Supplemental vitamin D on trial: no evidence of benefit as an adjuvant treatment for melanoma Get access Remco van Doorn Remco van Doorn Writing - original draft Department of Dermatology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Dermatology, Netherlands Cancer Institute, Amsterdam, the Netherlands Email: rvandoorn@lumc.nl https://orcid.org/0000-0002-7019-6673 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, ljae302, https://doi.org/10.1093/bjd/ljae302 Published: 23 July 2024 Article history Received: 11 July 2024 Accepted: 12 July 2024 Published: 23 July 2024 Corrected and typeset: 27 August 2024
A polymeric nanoplatform enhances the cGAS-STING pathway in macrophages to potentiate phagocytosis for cancer immunotherapy
Authors: Yongjuan Li, Jinmeng Yi, Rong Ma, Yayun Wang, Xiaohan Lou, Ya Dong, Yongjian Cao, Xinyan Li, Ming Wang, Xiaowei Dang, Rui Li, Ningjing Lei, Haiwei Song, Zhihai Qin, Weijing Yang
Journal: Journal of Controlled Release (2024)