tbuckley/cabot-search huggingface dataset:
Abstract 5510: Inflammation is Related to Coronary Flow Reserve Detected by Positron Emission Tomography in Healthy Twins
Authors: Viola Vaccarino, Durreshahwar Khan, John Votaw, Tracy Faber, Emir Veledar, Nancy V Murrah, Linda R Jones, Jack Goldberg, Paolo Raggi, Arshed A Quyyumi, J D Bremner
Journal: Circulation (2009)

Introduction. Coronary microvascular dysfunction is an early precursor of CAD and is thought to result from endothelial cell activation and inflammation. Coronary flow reserve (CFR) is an index of microvascular dysfunction, but limited and conflicting data exist on the relationship between CFR and inflammation. Methods. We examined 292 healthy male twins selected from the Vietnam Era Twin Registry. Plasma biomarkers of inflammation and endothelial cell activation were assessed and included C-reactive protein (CRP), interleukin-6 (IL-6), total white blood cell count (WBC), sVCAM-1 and sICAM-1. We performed myocardial perfusion imaging and blood flow quantitation with [13N] ammonia positron emission tomography at rest and after adenosine stress. CFR was measured as the ratio of maximum flow to baseline flow at rest averaged across 20 myocardial regions; abnormal CFR was defined as &lt;2.5. A summed stress score for visible perfusion defects was also calculated. Traditional CAD risk factors were also measured. Mixed-effect and GEE models were used to conduct matched-pair analyses. Results. The twins had a mean age of 54 and 57% were monozygotic. In the overall sample, all biomarkers except sVCAM-1 were significantly correlated with CFR. In contrast, only IL-6 was correlated with the summed stress score of visible defects. Of 146 twin pairs, 138 were discordant for CFR (using no cutpoint) and 56 pairs were discordant for CFR &lt;2.5. Values of all biomarkers were higher in twins with lower CFR than their brothers with higher CFR (Table ). The associations persisted after adjusting for summed stress score and CAD risk factors; after stratifying by zygosity results were similar. Conclusions. Systemic inflammation and endothelial cell activation are associated with coronary microvascular dysfunction, independent of CAD risk factors. Our results using a highly controlled twin design highlight the importance of inflammatory processes in the early phases of CAD. Percent Higher Biomarker Level in Twin with Lower CFR Compared to Brother with Higher CFR This research has received full or partial funding support from the American Heart Association, National Center.
Abstract 20702: Reoxygenation — Induced Activation of Golgi Resident eNOS Regulates Exocytosis in the Vascular Endothelium: The Role of Cytosolic Phosphatases
Authors: Saradhadevi Varadharaj, Lawrence J Druhan, Chun-An Chen, Tse-Yao Wang, Namakkal S Rajasekaran, Jay L Zweier
Journal: Circulation (2010)

Nitric Oxide (NO) elicits biological response by binding to heme moieties. The classic example is the activation of guanylate cyclase leading to smooth muscle relaxation. However, increasing data i...
Zn/Ag micro-galvanic couples formed on titanium and osseointegration effects in the presence of S. aureus
Authors: Guodong Jin, Hui Qin, Huiliang Cao, Yuqin Qiao, Yaochao Zhao, Xiaochun Peng, Xianlong Zhang, Xuanyong Liu, Paul K Chu
Journal: Biomaterials (2015)
Health of Children Attending Day Nurseries
Authors: M. E. McLaughlin
Journal: BMJ (1947)

wasteful.Moreover, if haematological and clinical improvement does not occur within two weeks it can be assumed that the disorder is not due to deficiency of folic acid and that continued administration of the vitamin is contraindicated.SummaryAn account is given of the results of treatment with folic acid of (a) 16 cases of pernicious anaemia, (b) 5 cases of refrac- tory megaloblastic anaemia, (c) 10 cases of the sprue syndrome, (d) 3 cases of subacute combined degeneration of the cord, (e) 5 cases of aplastic and hypoplastic anaemia, (f) 9 cases of leucopenia, (g) 9 cases of thrombocytopenia, and (/i) 5 cases of ulcerative colitis.A haemopoietic response was obtained only in the cases in which the bone marrow was megaloblastic-i.e., cases in groups a, b, and c.No therapeutic changes were obtained in cases of aplastic anaemia, leucopenia, or thrombocytopenia.In the sprue syndrome folic acid controlled the diarrhoea and produced general clinical improvement in adult patients suffering from tropical sprue and idiopathic steatorrhoea.Folic acid by itself seldom restored the blood level or blood picture to normal.In none of the cases of coeliac disease was any haematological or clinical improvement noted.The clinical and sigmoidoscopic appearances in 5 cases of idiopathic ulcerative colitis were unaffected by folic acid therapy.The rationale of the action of folic acid and the principles underlying its therapeutic administration are discussed.
Soundings: In which we served
Authors: Colin Douglas
Journal: BMJ (1999)

I first set foot in one almost 30 years ago. The Royal Naval Hospital (RNH) Gibraltar, a colonial delight perched high on the rock, seemed a perfect place to work: old fashioned, easy going, and distinctly underutilised. I was just visiting, paying my respects as a lowly seaborne reservist to a surgeon captain who welcomed me kindly.

Later I served there as a locum physician. The other three doctors were an anaesthetist, a surgeon, and an obstetrics and gynaecology man, so my remit ran from neonatology through general medicine to things like psychiatry and dermatology. A little worrying, but fortunately very little happened.

RNH Malta was more serious, a vast colonnaded block high on the quiet side of the island. In summer in the mid-1970s naval hospital medicine at Mtarfa still ran at an agreeable colonial pace. Doctors drifted around in the mornings in white shirts and shorts, like ethereal boy scouts, and were little to be seen in the afternoons. I learnt quite a lot. It closed long ago.

There was even a naval hospital in Mauritius. I tried quite hard to check it out, suggesting to the appointer, as only a reservist could, that a couple of months there might help me make up my mind about signing on as a regular. He was fairly desperate—even his Irishmen were leaving—but we compromised instead on the Malta posting. But I still wonder sometimes what RNH Mauritius—also of course now closed—was really like.

In May 1982 RNH Devonport was eerily empty, cleared for the hundreds of Falklands casualties that never came. Each night we watched the war on the six o’clock news. On Sundays the hospital chapel was full and the naval hymn, “O hear us when we cry to thee for those in peril on the sea,” was sung with real feeling. The hospital has since closed.

Now the Royal Hospital Haslar, once the biggest and best, is to go too. In a few years the long RNH tradition of service and eccentricity will finally vanish and thousands of doctors who were part of it, even briefly and sometimes unwillingly, will sense the loss. The charm of the naval hospitals lay in their being just a little behind the times, generally never too busy, and always part of a greater service whose traditions they shared. Clubby, orderly, quaint, and decently resourced, they were everything that the current frontline NHS is not—clearly the reason they had to go, but a reason also to mourn their passing.
Abstract 13642: Hospitalist Care and Associated Outcomes for Patients Hospitalized with Heart Failure: Insights from Get With The Guidelines-Heart Failure
Authors: Robb D Kociol, Bradley G Hammill, Gregg C Fonarow, Paul A Heidenreich, Eric D Peterson, Lesley H Curtis, Adrian F Hernandez
Journal: Circulation (2011)

Background: The use of hospitalists to care for general medical admissions has increased nationally, but the role of hospitalists and associated patient outcomes among heart failure (HF) admissions are poorly described. Methods: We analyzed data from hospitals participating in the GWTG-HF registry from 2005-2008 linked to Medicare claims. The exposure of interest was the hospital's rate of use of hospitalists as attendings for HF stays, determined annually using Medicare claims data. We examined outcomes for patients stratified by hospital type - academic teaching hospitals, non-academic tertiary hospitals (non-teaching with cardiology services), and small community hospitals (non-teaching without cardiology services). Using multivariable models, we estimated the relationship between hospital-level use of hospitalists and patient-level risk-adjusted outcomes - 30-day readmission, 30-day mortality, and length of stay (LOS). Results: Our analysis included 31,504 Medicare beneficiaries in 166 hospitals. Medi...
Meeting health needs of asylum seekers
Authors: H. Hogan, P. Matthews
Journal: BMJ (1999)

Carriage of meningococci in contacts of patients with meningococcal disease"Kissing contacts" need to be defined Editor-In their study Kristiansen et al show high carriage rates of pathogenic strains of Neisseria menigitidis in household and kissing contacts of patients with invasive meningococcal disease. 1 While it is easy to define a household contact it may be more difficult to define a kissing contact.There are many types of kiss, ranging from a "peck on the cheek" to much more!In some cultures kissing is as common as shaking hands.In such situations widespread chemoprophylaxis to "kissing contacts" may not be appropriate.It would be valuable to know whether Kristiansen et al placed any restrictions on who was defined as a kissing contact.
More geriatricians are needed
Authors: D. Black
Journal: BMJ (1994)

EDITOR,—Jackie Morris reminds us of the challenge to primary care of both the increasing numbers of frail elderly people in the community and the complexity of the problems they present.1 The issue of community geriatricians is, unfortunately, also complex. One of the main driving forces behind the interest in community geriatricians has been purchasers frightened by the apparently irresistible rise in emergency admissions to hospital—about 10% last year. They have raised the question whether the appointment of community geriatricians …
Abstract P153: Racial Disparities in Diabetic Complications in a Middle and Low Income Population of Louisiana
Authors: Yujie Wang, Wei Li, Liwei Chen, Ronald Horswell, Wenting Xie, Ke Xiao, Jay Besse, Jolene Johnson, Peter Katzmarzyk, Donna Ryan, Gang Hu
Journal: Circulation (2012)

Background: Although coronary heart disease (CHD), heart failure (HF), stroke, and end-stage renal disease (ESRD) are major microvascular and macrovascular complications of diabetes, they are less clear for diabetic subgroups especially on those with middle and low income. Aim: To investigate racial disparities in the incidence of diabetic complications in middle and low income adults. Methods: We performed a prospective cohort study (1985-2010) on diabetic patients enrolled in the LSU Hospital-Based Longitudinal Study. Study cohorts included 89,353 diabetic patients (16,326 White men, 21,496 White women, 19,422 African American men and 32,109 African American women) who were 30 to 96 years of age. We calculated the gender specific age-standardized incident rates using the direct method to the year 2010 Census population. Cox proportional hazard models were used to compare racial or gender specific hazard ratios for CHD, HF, stroke and ESRD after adjustment for age, race, type of health insurance, family income, body mass index, smoking, systolic blood pressure, LDL cholesterol, HDL cholesterol, HbA 1c , estimated GFR, albuminuria, and drug treatments for diabetes, hypertension and hyperlipidemia. Results: During an average 4.0 years of follow-up, 16,935 CHD, 13,421 HF, 6,804 stroke, and 13,281 ESRD incident cases were ascertained. The age-standardized incident rates of the four diabetic complications are presented in table 1 . Compared with White diabetic patients, African Americans experienced higher rates of ESRD and lower rates of CHD, HF, and stroke. Female diabetic patients had lower rates of the four complications than males. Results of the Cox proportional hazard models confirmed the racial disparity and gender difference we found in the age-standardized incident rates. Conclusions: The results support the existence of racial differences in the incidence of diabetic complications in this population. Table 1 Age-adjusted incident rates of type 2 diabetes complications in the LSUHLS study Age-standardized incident rates White African American Male Female Male Female Coronary Heart Disease 101.6 (98.8-104.5) 62.0 (60.4-63.7) 50.7 (49.2-52.2) 44.4 (43.4-45.5) Heart Failure 54.9 (52.9-56.8) 41.9 (40.6-43.1) 43.4 (42.0-44.8) 38.4 (37.4-39.3) Stroke 22.1 (20.9-23.3) 20.7 (19.8-21.6) 19.9 (19.0-20.8) 18.5 (17.8-19.1) End-stage Renal Disease 43.3 (41.6-45.0) 33.4 (32.2-34.5) 51.4 (50.0-52.9) 35.2 (34.3-36.1)
The in-vitro effects of medroxyprogesterone acetate on acidic pH induced apoptosis of periferal blood mononuclear cells.
Authors: F Ozdemir, E Ovali, F Aydin, H Kavgaci, A Büyükcelik, F Ucar, M Sönmez
Journal: Journal of experimental & clinical cancer research (2004)

Medroxyprogesterone acetate (MPA) which has a steroid structure, is widely used in oncology practice in the treatment of the cachexia of cancer and to reduce hematologic toxicity in patients receiving chemotherapy. However, the mechanisms of MPA on these effects are unclear. In this study, we investigated the effects of two different doses of MPA (10(-5) and 10(-6) M/L) on acidic pH induced apoptosis of periferal blood mononuclear cells (PBMC) derived from 10 healthy volunteers. Compared with the control group, we found that MPA at the dose of 10(-5) M/L had a negative effect on apoptosis (32.88 +/- 4.61 and 20.7 +/- 1.53% respectively, p < 0.05), a positive effect on cell count of PBMC (1395 +/- 151 x 10(3) and 1100 +/- 139 x 10(3) respectively, p < 0.05) and no effects on cell viability and its proliferation. More comprehensive trials are needed to clarify this effect of MPA.
Opiate detoxification under anaesthesia
Authors: J. Strang, J. Bearn, M. Gossop, C. Brewer
Journal: BMJ (1999)

Editor—Our letter1 was a response to Brewer’s own letter2 and reported reasons why we had decided not to collaborate with him on the study of opiate detoxification under anaesthesia. Brewer has expressed concern to us that our expression of “dislike of Brewer’s proposal that NHS funds should be diverted from the NHS into his private treatment business” raised an inference of professional impropriety on his part and implied that his motives for wanting to collaborate were at least in part to enrich himself with NHS funds, and that our earlier mention of the need for “objectivity and equipoise” in medical researchers could be considered to be an implication that he might in some way behave dishonestly if a trial were to be conducted. We accept that Brewer’s offers of collaboration were made on an ordinary friendly academic basis. We regret that we misunderstood this, and we apologise if our letter seemed to cast doubt on his probity and objectivity. It was certainly not our intention to do so, and we regret any distress that our letter may have caused.

Our letter also reported our concerns about the potential hazards of the procedure. The final sentence of our letter had been altered by the BMJ without consultation with ourselves. The original letter had referred to “several deaths, whether directly or indirectly related, including one in not dissimilar circumstances under Brewer’s own care ... .” The omission of the qualifying phrase “in not dissimilar circumstances” left open the implication that the death had occurred during detoxification under anaesthesia, which is not correct. The death has already been described by Brewer3 as was referenced in our letter1: the detoxification, had also involved sudden antagonist challenge, although it had been undertaken under heavy sedation, not anaesthesia, and in a psychiatric rather than an intensive care treatment setting. We regret any confusion caused to readers and distress experienced by Brewer.
Characterization of Residential Pesticide Use and Chemical Formulations through Self-Report and Household Inventory: The Northern California Childhood Leukemia Study
Authors: Neela Guha, Mary H. Ward, Robert Gunier, Joanne S. Colt, C. Suzanne Lea, Patricia A. Buffler, Catherine Metayer
Journal: Environmental Health Perspectives (2012)

Home and garden pesticide use has been linked to cancer and other health outcomes in numerous epidemiological studies. Exposure has generally been self-reported, so the assessment is potentially limited by recall bias and lack of information on specific chemicals.As part of an integrated assessment of residential pesticide exposure, we identified active ingredients and described patterns of storage and use.During a home interview of 500 residentially stable households enrolled in the Northern California Childhood Leukemia Study during 2001-2006, trained interviewers inventoried residential pesticide products and queried participants about their storage and use. U.S. Environmental Protection Agency registration numbers, recorded from pesticide product labels, and pesticide chemical codes were matched to public databases to obtain information on active ingredients and chemical class. Poisson regression was used to identify independent predictors of pesticide storage. Analyses were restricted to 259 participating control households.Ninety-five percent (246 of 259) of the control households stored at least one pesticide product (median, 4). Indicators of higher sociodemographic status predicted more products in storage. We identified the most common characteristics: storage areas (garage, 40%; kitchen, 20%), pests treated (ants, 33%; weeds, 20%), pesticide types (insecticides, 46%; herbicides, 24%), chemical classes (pyrethroids, 77%; botanicals, 50%), active ingredients (pyrethrins, 43%) and synergists (piperonyl butoxide, 42%). Products could contain multiple active ingredients.Our data on specific active ingredients and patterns of storage and use will inform future etiologic analyses of residential pesticide exposures from self-reported data, particularly among households with young children.
The OsSPL16-GW7 regulatory module determines grain shape and simultaneously improves rice yield and grain quality
Authors: Shaokui Wang, Shan Li, Qian Liu, Kun Wu, Jianqing Zhang, Shuansuo Wang, Yi Wang, Xiangbin Chen, Yi Zhang, Caixia Gao, Feng Wang, Haixiang Huang, Xiangdong Fu
Journal: Nature Genetics (2015)
Abstract 1322: Exercise Stimulates Angiogenesis and Improves {beta}-Adrenergic Receptor Signaling in the Failing Heart
Authors: Luca Golino, Dario Leosco, Guido Iaccarino, Giuseppe Rengo, Fondazione S. Maugeri, Vincenzo Cimini, Giovanna G Altobelli, Emma Sanzari, Gianfranco Matrone, Francesca Fortunato, Carmela Zincarelli, Daniela Sorriento, Walter J Koch, Franco Rengo
Journal: Circulation (2006)

Cardiac angiogenesis is impaired in the failing heart. Exercise is shown to stimulate cardiac angiogenesis in physiologic conditions and in infarcted hearts. The aim of this study was to evaluate w...
Abstract 3208: Identification of Novel Genes Involved in Mouse Myocardial Rhomboid Protease Signaling
Authors: Lin Yu, Teresa Lee, Matthew Wolf
Journal: Circulation (2009)

Recently we identified that the inhibition of Rhomboid-3 causes a dilated cardiomyopathy in adult Drosophila. Rhomboids are seven transmembrane spanning intra-membrane serine proteases that are hig...
Abstract 13568: Lack of Association between Increasing Levels of Hemoglobin A1c and Coronary Atherosclerosis in Non-Diabetic Acute Myocardial Infarction Patients
Authors: Wassef Karrowni, John A Spertus, Yan Li, Darren K McGuire, Thomas M Maddox, Sharon Cresci, Mouin Abdallah, David E Lanfear, Phillip A Horwitz
Journal: Circulation (2012)
Abstract P059: Reproducibility of Blood Pressure Response to Cold Pressor Test: the GenSalt Study
Authors: Dongfeng Gu, Lydia A Bazzano, Jie Cao, Jianxin Li, Jichun Chen, Jianfeng Huang, Jing Chen, Tanika Kelly, Qi Zhao, Chung-Shiuan Chen, Dongsheng Hu, Jixiang Ma, Treva Rice, Jiang He
Journal: Circulation (2012)

Higher blood pressure (BP) response to cold pressor test (CPT) is associated with increased risk of hypertension and cardiovascular diseases. However, it is unknown whether BP response to CPT is a stable and reproducible trait. We repeated the CPT among 568 Han Chinese who participated in the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) four years after the original study. The same CPT protocol was applied in the original and repeated studies. BP was measured prior to and at 0, 1, 2, and 4 minutes after the participants immersed their hand in ice water (3 o C to 5 o C) for 1 minute using a standard mercury sphygmomanometer. On average, study participants were 39.0 years old and 54.0% of them were male. The mean body mass index was 23.6 kg/m 2 , systolic BP was 117.8 mmHg, and diastolic BP was 74.5 mmHg at baseline among study participants. The mean (standard deviation) of systolic BP responses at time 0 and 1 minutes, maximum responses, and area-under-the-curve during CPT were 13.3 (10.1), 4.2 (6.0), 13.6 (9.8) and 10.8 (17.6) mmHg in the original study and 11.1 (9.5), 4.1 (6.0), 11.7 (8.9), and 10.1 (17.1) mmHg in the repeated study. BP responses in the original and repeated studies were highly correlated. For example, the correlation coefficients for systolic BP responses to CPT were 0.4137 at time 0 minute, 0.3711 at time 1 minute, 0.4221 for the maximum responses, and 0.3641 for area-under-the-curve during CPT (all p&lt;0.0001). These data indicate that BP response to CPT is a stable and reproducible trait. Furthermore, BP responses to CPT may be useful for identifying individuals at high risk for hypertension.
Anoxic Asphyxia – a Cause of Industrial Fatalities: A Review
Authors: P B James, I M Calder
Journal: Journal of the Royal Society of Medicine (1991)

The investigation of commercial diving accidents has indicated that the danger of anoxia, from the inhalation of gases not containing oxygen, is not fully recognized. The problem is more common in a variety of general industrial situations and is an occasional cause of death in anaesthesia. It is a particular hazard with inert gases, which, because they are recognized to be non-toxic, give a false sense of security. The pathological findings consist of pulmonary oedema and petechial haemorrhages, mainly in the brain, lungs and myocardium. Whenever possible, a minimum oxygen content should be included in all gases liable to be respired, but where this is not possible, oxygen analysers and alarms should be provided. Where a general hazard exists, personnel must be warned of the danger.