tbuckley/cabot-search huggingface dataset:
<i>TOLLIP</i> Single Nucleotide Polymorphism and Antimicrobial Treatment Effect in Idiopathic Pulmonary Fibrosis
Authors: William Whalen, Kristin Berger, John S. Kim, Will Simmons, Shwu-Fan Ma, Robert J Kaner, Fernando J. Martinez, Kevin J. Anstrom, Helen Parfrey, Toby Maher, Matt Hammond, Allan B. Clark, David Thickett, R. Gisli Jenkins, Andrew M. Wilson, Imre Noth
Journal: American Journal of Respiratory and Critical Care Medicine (2024)
Implications of Race Adjustment in Lung-Function Equations
Authors: James A Diao, Yixuan He, Rohan Khazanchi, Max Jordan Nguemeni Tiako, Jonathan I Witonsky, Emma Pierson, Pranav Rajpurkar, Jennifer R Elhawary, Luke Melas-Kyriazi, Albert Yen, Alicia R Martin, Sean Levy, Chirag J Patel, Maha Farhat, Luisa N Borrell, Michael H Cho, Edwin K Silverman, Esteban G Burchard, Arjun K Manrai
Journal: New England Journal of Medicine (2024)

Adjustment for race is discouraged in lung-function testing, but the implications of adopting race-neutral equations have not been comprehensively quantified.
Beyond Diagnostics — Removing Race from Lung-Function Test Interpretation
Authors: Meredith McCormack, David A Kaminsky
Journal: New England Journal of Medicine (2024)

In 2020, the Journal published a Medicine and Society article, "Hidden in Plain Sight — Reconsidering the Use of Race Correction in Clinical Algorithms," which was inspired by the authors' observations during their time as medical students.1 They asserted that as our understanding of race has advanced, clinical tools should reflect new insights, remain scientifically rigorous, and make medicine a more antiracist field. In the field of pulmonary medicine, the American Thoracic Society (ATS) has made recommendations to move to a race-neutral approach to interpreting pulmonary-function test results.2 The size of healthy lungs depends on age, height, and sex, with . . .
Pamrevlumab for Idiopathic Pulmonary Fibrosis
Authors: Ganesh Raghu, Luca Richeldi, Evans R. Fernández Pérez, Maria Cristina De Salvo, Rafael S. Silva, Jin Woo Song, Takashi Ogura, Zuo Jun Xu, Elizabeth A. Belloli, Xueping Zhang, Lorilyn L. Seid, Lona Poole, Simon Bowler, Tamera Corte, Mark Holmes, Francis Thien, John Wheatley, Sun-Mi Choi, Man-Pyo Chung, Sunghwan Jeong, Yonghyun Kim, Eun-Joo Lee, Hyun-Kyung Lee, Choonsik Park, Jong Sun Park, Joo Hun Park, David Chi-Leung Lam, Ming-Cheng Chan, Kang-Yun Lee, Jie Cao, Juan Chen, Rongchang Chen, Huaping Dai, Xiuhua Fu, Zongan Liang, Qun Luo, Guochao Shi, Zhaohui Tong, Limin Wang, Shuanying Yang, Hongtao Yu, Huilan Zhang, Jianchu Zhang, Hui Zhao, Wei Wang, Ying Meng, Hong Peng, Murali Ramaswamy, Mark Hamblin, John Fitzgerald, Nishant Gupta, Jane Dematte, Srihari Veeraraghavan, Thomas O’Brien, Tracy Luckhardt, Lisa Lancaster, Marta Kokoszynska, Neil Ettinger, Thomas D. Kaelin, Ather Siddiqi, Bridget Collins, Mary Beth Scholand, Danielle Antin-Ozerkis, Kim Hyun, Christopher Harden, Frank Averill, Jorge Mallea, Rebecca Bascom, Vandana Seeram, Amy Hajari Case, Edward Britt, Barry Shea, Gerard Criner, Mark Gotfried, Yolanda Mageto, Sherif El Bayadi, Cristina Reichner, Joshua Mooney, David Hotchkin, Rodeo Abrencillo, Ryan Boente, Joyce Lee, Alan Betensley, Niranjan Jeganathan, Rajat Walia, Timothy Albertson, Ivan Rosas, Dileep Puppala, Ladly Abraham, Richard Enelow, Nitin Bhatt, Debabratra Bandyopadhyay, Pedro Carlos Elias, Miguel Bergna, Gabriel Ricardo Garcia, Gaston De Stefano, Luis Arturo Wehbe, Alejandro Chirino, Ramon Rojas, Maria Otaola, Georgina Miranda, Matias Florenzano, Rafael Silva Orellana, Valeska Glasinovich, Olga Shangina, Alexey Nikishenkov, Natalia Kuzubova
Journal: JAMA (2024)

Current treatments for idiopathic pulmonary fibrosis slow the rate of lung function decline, but may be associated with adverse events that affect medication adherence. In phase 2 trials, pamrevlumab (a fully human monoclonal antibody that binds to and inhibits connective tissue growth factor activity) attenuated the progression of idiopathic pulmonary fibrosis without substantial adverse events.
β-Blockers in Chronic Obstructive Pulmonary Disease—Walking the Tightrope
Authors: MeiLan K. Han, Mark T. Dransfield
Journal: JAMA (2024)

Graham Devereux, MD; Seonaidh Cotton, PhD; Mintu Nath, PhD; Nicola McMeekin, PhD; Karen Campbell, MSc; Rekha Chaudhuri, MD; Gourab Choudhury, MD; Anthony De Soyza, PhD; Shona Fielding, PhD; Simon Gompertz, MD; John Haughney, MD; Amanda J. Lee, PhD; Graeme MacLennan, MSc; Alyn Morice, MD; John Norrie, MSc; David Price, MD; Philip Short, MD; Jorgen Vestbo, MD; Paul Walker, MD; Jadwiga Wedzicha, MD; Andrew Wilson, MD; Olivia Wu, PhD; Brian J. Lipworth, MD
Apixaban vs Aspirin According to CHA2DS2-VASc Score in Subclinical Atrial Fibrillation
Authors: Renato D Lopes, Christopher B Granger, Daniel M Wojdyla, William F McIntyre, Marco Alings, Thenmozhi Mani, Chinthanie Ramasundarahettige, Lena Rivard, Dan Atar, David H Birnie, Giuseppe Boriani, Guy Amit, Peter Leong-Sit, Claus Rinne, Gabor Z Duray, Michael R Gold, Stefan H Hohnloser, Valentina Kutyifa, Juan Benezet-Mazuecos, Jens Cosedis Nielsen, Christian Sticherling, Alexander P Benz, Cecilia Linde, Joseph Kautzner, Philippe Mabo, Georges H Mairesse, Stuart J Connolly, Jeff S Healey
Journal: Journal of the American College of Cardiology (2024)
Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation
Authors: Graham Devereux, Seonaidh Cotton, Mintu Nath, Nicola McMeekin, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Amanda J. Lee, Graeme MacLennan, Alyn Morice, John Norrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Olivia Wu, Brian J. Lipworth
Journal: JAMA (2024)

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Observational studies report that β-blocker use may be associated with reduced risk of COPD exacerbations. However, a recent trial reported that metoprolol did not reduce COPD exacerbations and increased COPD exacerbations requiring hospital admission.
Body Composition and Its Response to Intradialytic Exercise in Kidney Failure: A Combined Analysis of the PEDAL and CYCLE-HD Randomised Controlled Trials
Authors: Khai Ping Ng, Jamie H. Macdonald, Robin Young, Daniel S. March, Matthew Graham-Brown, Tom Mercer, Sharlene A. Greenwood, James Burton, Indranil Dasgupta
Journal: Journal of the American Society of Nephrology (2023)
Classification of Arteriovenous Access Aneurysm in Hemodialysis Patients Using Artificial Intelligence Application
Authors: Zijun Dong, Hanjie Zhang, Lin-Chun Wang, Sarah Ren, Lela Tisdale, Maggie Han, Shahzre Mohib, Laura M. Rosales, Sindhuri Prakash-Polet, Denzil Douglas, Piotr Starakiewicz, Dean C. Preddie, Stephan Thijssen, Peter Kotanko
Journal: Journal of the American Society of Nephrology (2023)
Development of Artificial Intelligence Model for the Prediction of AKI, Acute Kidney Disease, and CKD After General Anesthesia Surgery
Authors: Sang Hun Eum, Ji Won Min, Eun Sil Koh, Tae Hyun Ban, Suyeon Hong, Byung ha Chung, Yong Kyun Kim, Seok Joon Shin, Hye Eun Yoon
Journal: Journal of the American Society of Nephrology (2023)
Association Between Physical Activity and Renal Outcomes in Patients with CKD G3b-5: A Result from a Japanese Cohort Study, the REACH-J
Authors: Junichi Hoshino, Ryoya Tsunoda, Hirayasu Kai, Chie Saito, Hirokazu Okada, Ichiei Narita, Takashi Wada, Shoichi Maruyama, Kunihiro Yamagata
Journal: Journal of the American Society of Nephrology (2023)
Association Between Laxative Use and Serum Phosphate Levels in Patients with CKD: A Large Nationwide Observational Study of US Veterans
Authors: Keiichi Sumida, Yamini Mallisetty, Prabin Shrestha, Satya Surbhi, Fridtjof Thomas, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy
Journal: Journal of the American Society of Nephrology (2023)
Improving Compliance with CKD Screening and Monitoring in a Resident Continuity Clinic
Authors: McKenna Eisenbeisz, Adam Blaine, Kimiya Nourian, Alexander A. Garza, Colten C. Stewart, Erin L. Sternhagen, Lisa M. Antes, Diana I. Jalal, Melissa L. Swee
Journal: Journal of the American Society of Nephrology (2023)
IMPACT CKD: Projecting the Growing Environmental Burden of CKD in the United States
Authors: Stacey Priest, Hannah A. Guiang, Charlotte M. Johnston-Webber, Naveen Rao, Jieling Chen, Durgesh Bhandary, Rachele Berria, Stephen Brown, Daniel Grima, Neil Skolnik
Journal: Journal of the American Society of Nephrology (2023)
Empowering Dialysis Patients to Self-Manage Hyperphosphatemia with Mobile Health Technology: Insights from the FOSFO-OK Study
Authors: Miguel Hueso, Ronny I. Rodriguez Urquia, Rafael Alvarez Esteban, Maria Quero, Gustavo E. Villalobos, Claudia Galofre, Roser Peiró-Jordán, David M. Martínez, Alfredo Vellido
Journal: Journal of the American Society of Nephrology (2023)
Associations of Plasma Trimethylamine N-Oxide-Related Metabolites with the Development and Progression of Albuminuria
Authors: Meng Wang, W.H. Wilson Tang, Xinmin S. Li, Marcia C. De Oliveira Otto, Rozenn Lemaitre, Amanda M. Fretts, Ina Nemet, Nona Sotoodehnia, Matthew J. Budoff, Joseph A. Didonato, Zeneng Wang, Mark J. Sarnak, Dariush Mozaffarian, Stanley L. Hazen
Journal: Journal of the American Society of Nephrology (2023)
Performance of GFR Estimating Equations in Kidney Transplant Recipients of Various Races
Authors: Pooja Budhiraja, Richard J. Butterfield, Raymond L. Heilman, Musab S. Hommos, Hay Me Me, Wisit Cheungpasitporn, Salah B. Alajous, Tejas S. Khurana, Hasan Khamash
Journal: Journal of the American Society of Nephrology (2023)
Food Insecurity and High Blood Pressure Among Individuals with CKD in West Africa
Authors: Raghavee Neupane, Titilayo O. Ilori, Runqi Zhao, Sushrut S. Waikar, Edward P. Kwakyi, Jessica Chern, Ifeoma I. Ulasi, Adaobi Solarin, Dwomoa Adu, Manmak Mamven, Rasheed A. Gbadegesin
Journal: Journal of the American Society of Nephrology (2023)
Characteristics and Outcomes of a Lupus Nephritis Cohort From Latin America
Authors: María F. Zavala Miranda, Abril A. Pérez Arias, Sofia E. M. Macedo, Luis E. Morales-Buenrostro, Roque A. Comunidad Bonilla, Juan M. Mejia-Vilet
Journal: Journal of the American Society of Nephrology (2022)
Predictive Modeling of Graft Failure Risk in Deceased Donor Kidney Transplants: Leveraging Machine Learning for Improved Outcomes and Data-Driven Insights
Authors: Amankeldi Salybekov, Ainur Yerkos, Aidyn D. Kunikeyev, Zholdas Buribayev, Yasuhiro Mochida, Kunihiro Ishioka, Sumi Hidaka, Shuzo Kobayashi
Journal: Journal of the American Society of Nephrology (2023)
Lubiprostone Inhibits Progression of Renal Failure via Intestinal Microbiome
Authors: Shun Watanabe, Masaaki Nakayama, Takashi Yokoo, Satoru Sanada, Katsuhiko Asanuma, Yusuke Suzuki, Tsuneo Konta, Takaaki Abe
Journal: Journal of the American Society of Nephrology (2023)
Integrating Electronic Health Data Records to Develop and Validate a Predictive Model of Hospital-Acquired AKI in Non-Critically Ill Patients
Authors: Alfonso Segarra, Jacqueline Del Carpio Salas, Natalia Ramos, Jorge González, Jose Bruno Montoro Ronsano, Silvia Pico Fornies, Marina Canales Navarro, María P. Marco, Elias A. Jatem, Pamela J. Chang
Journal: Journal of the American Society of Nephrology (2023)
CKD Risk Factors by Cluster in Mild- and Moderate-Risk Individuals
Authors: Tadashi Toyama, Megumi Oshima, Shinji Kitajima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Yasunori Iwata, Takashi Wada
Journal: Journal of the American Society of Nephrology (2022)

Toyama, Tadashi; Oshima, Megumi; Kitajima, Shinji; Hara, Akinori; Sakai, Norihiko; Shimizu, Miho; Iwata, Yasunori; Wada, Takashi Author Information
Effects of Sacubitril/Valsartan on Hypertension in Patients With CKD Stage 5D
Authors: Nan Chen, Xiao Li, Li Lin
Journal: Journal of the American Society of Nephrology (2022)

Journal of the American Society of Nephrology 33(11S):p 986, November 2022. | DOI: 10.1681/ASN.20223311S1986c
Early Diagnosis and Treatment of COPD and Asthma — A Randomized, Controlled Trial
Authors: Shawn D Aaron, Katherine L Vandemheen, G Alex Whitmore, Celine Bergeron, Louis-Philippe Boulet, Andréanne Côté, R Andrew McIvor, Erika Penz, Stephen K Field, Catherine Lemière, Irvin Mayers, Mohit Bhutani, Tanweer Azher, M Diane Lougheed, Samir Gupta, Nicole Ezer, Christopher J Licskai, Paul Hernandez, Martha Ainslie, Gonzalo G Alvarez, Sunita Mulpuru
Journal: New England Journal of Medicine (2024)

Many persons with chronic obstructive pulmonary disease (COPD) or asthma have not received a diagnosis, so their respiratory symptoms remain largely untreated.
Pleasurable and problematic receptive anal intercourse and diseases of the colon, rectum and anus
Authors: Daniel R Dickstein, Collin R Edwards, Catherine R Rowan, Bella Avanessian, Barbara M Chubak, Christopher W Wheldon, Priya K Simoes, Michael H Buckstein, Laurie A Keefer, Joshua D Safer, Keith Sigel, Karyn A Goodman, B R Simon Rosser, Stephen E Goldstone, Serre-Yu Wong, Deborah C Marshall
Journal: Nature Reviews Gastroenterology & Hepatology (2024)

The ability to experience pleasurable sexual activity is important for human health. Receptive anal intercourse (RAI) is a common, though frequently stigmatized, pleasurable sexual activity. Little is known about how diseases of the colon, rectum, and anus and their treatments affect RAI. Engaging in RAI with gastrointestinal disease can be difficult due to the unpredictability of symptoms and treatment-related toxic effects. Patients might experience sphincter hypertonicity, gastrointestinal symptom-specific anxiety, altered pelvic blood flow from structural disorders, decreased sensation from cancer-directed therapies or body image issues from stoma creation. These can result in problematic RAI — encompassing anodyspareunia (painful RAI), arousal dysfunction, orgasm dysfunction and decreased sexual desire. Therapeutic strategies for problematic RAI in patients living with gastrointestinal diseases and/or treatment-related dysfunction include pelvic floor muscle strengthening and stretching, psychological interventions, and restorative devices. Providing health-care professionals with a framework to discuss pleasurable RAI and diagnose problematic RAI can help improve patient outcomes. Normalizing RAI, affirming pleasure from RAI and acknowledging that the gastrointestinal system is involved in sexual pleasure, sexual function and sexual health will help transform the scientific paradigm of sexual health to one that is more just and equitable. Receptive anal intercourse (RAI) is an important consideration in gastrointestinal disorders and cancers. This Review discusses the anorectum as a sexual organ, providing an overview of pleasurable and problematic RAI and how gastrointestinal disease itself and associated treatments (such as surgery) can affect RAI. Strategies to manage problematic RAI to improve sexual health are also described.
Low-Friction Soft Robots for Targeted Bacterial Infection Treatment in Gastrointestinal Tract
Authors: Ben Wang, Yunrui Chen, Zhicheng Ye, Haidong Yu, Kai Fung Chan, Tiantian Xu, Zhiguang Guo, Weimin Liu, Li Zhang
Journal: Cyborg and Bionic Systems (2024)

Untethered and self-transformable miniature robots are capable of performing reconfigurable deformation and on-demand locomotion, which aid the traversal toward various lumens, and bring revolutionary changes for targeted delivery in gastrointestinal (GI) tract. However, the viscous non-Newtonian liquid environment and plicae gastricae obstacles severely hamper high-precision actuation and payload delivery. Here, we developed a low-friction soft robot by assembly of densely arranged cone structures and grafting of hydrophobic monolayers. The magnetic orientation encoded robot can move in multiple modes, with a substantially reduced drag, terrain adaptability, and improved motion velocity across the non-Newtonian liquids. Notably, the robot stiffness can be reversibly controlled with magnetically induced hardening, enabling on-site scratching and destruction of antibiotic-ineradicable polymeric matrix in biofilms with a low-frequency magnetic field. Furthermore, the magnetocaloric effect can be utilized to eradicate the bacteria by magnetocaloric effect under high-frequency alternating field. To verify the potential applications inside the body, the clinical imaging-guided actuation platforms were developed for vision-based control and delivery of the robots. The developed low-friction robots and clinical imaging-guided actuation platforms show their high potential to perform bacterial infection therapy in various lumens inside the body.
Integrated Design and Fabrication of Pneumatic Soft Robot Actuators in a Single Casting Step
Authors: Afonso Silva, Diogo Fonseca, Diogo M. Neto, Mihail Babcinschi, Pedro Neto
Journal: Cyborg and Bionic Systems (2024)

Bio-inspired soft robots have already shown the ability to handle uncertainty and adapt to unstructured environments. However, their availability is partially restricted by time-consuming, costly and highly supervised design-fabrication processes, often based on resource intensive iterative workflows. Here, we propose an integrated approach targeting the design and fabrication of pneumatic soft actuators in a single casting step. Molds and sacrificial water-soluble hollow cores are printed using fused filament fabrication (FFF). A heated water circuit accelerates the dissolution of the core's material and guarantees its complete removal from the actuator walls, while the actuator's mechanical operability is defined through finite element analysis (FEA). This enables the fabrication of actuators with non-uniform cross sections under minimal supervision, thereby reducing the number of iterations necessary during the design and fabrication processes. Three actuators capable of bending and linear motion were designed, fabricated, integrated and demonstrated as three different bio-inspired soft robots, an earthworm-inspired robot, a four-legged robot, and a robotic gripper. We demonstrate the availability, versatility and effectiveness of the proposed methods, contributing to accelerating the design and fabrication of soft robots. This study represents a step toward increasing the accessibility of soft robots to people at a lower cost.
Impact of High Dose Early Mobilization on Outcomes for Patients with Diabetes: A Secondary Analysis of the TEAM Trial
Authors: Ary Serpa Neto, Michael Bailey, Daniel Seller, Alicia Agli, Rinaldo Bellomo, Kathy Brickell, Tessa Broadley, Heidi Buhr, Belinda J. Gabbe, Doug W. Gould, Meg Harrold, Alisa M. Higgins, Sally Hurford, Theodore J. Iwashyna, Alistair D. Nichol, Jeffrey J. Presneill, Stefan J. Schaller, Janani Sivasuthan, Claire J. Tipping, Alex Poole, Rachael Parke, Scott Bradley, Steven Webb, Sophia Zoungas, Paul J. Young, Carol L. Hodgson
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

Patients with diabetes represent almost 20% of all ICU admissions and might respond differently to high-dose early active mobilization.
Potential Diaphragm Muscle Weakness-related Dyspnea Persists Two Years after COVID-19 and Could Be Improved by Inspiratory Muscle Training: Results of an Observational and an Interventional Trial
Authors: Jens Spiesshoefer, Binaya Regmi, Mehdi Senol, Benedikt Jörn, Oscar Gorol, Mustafa Elfeturi, Stephan Walterspacher, Alberto Giannoni, Florian Kahles, Rainer Gloeckl, Michael Dreher
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

Diaphragm muscle weakness might underlie persistent exertional dyspnea, despite normal lung and cardiac function in individuals who were previously hospitalized for acute coronavirus disease (COVID-19) illness.
Biofabrication of Tissue‐Engineered Cartilage Constructs through Faraday Wave Bioassembly of Cell‐laden Gelatin Microcarriers
Authors: Jing Zhu, Qiuchen Luo, Guang Yang, Lin Xiao
Journal: Advanced Healthcare Materials (2024)

Acoustic biofabrication is an emerging strategy in tissue engineering due to its mild and fast manufacturing process. Herein, tissue-engineered cartilage constructs with high cell viability are fabricated from cell-laden gelatin microcarriers (GMs) through Faraday wave bioassembly, a typical acoustic "bottom-up" manufacturing process. Assembly modules are first prepared by incorporating cartilage precursor cells, the chondrogenic cell line ATDC5, or bone marrow-derived mesenchymal stem cells (BMSCs), into GMs. Patterned structures are formed by Faraday wave bioassembly of the cell-laden GMs. Due to the gentle and efficient assembly process and the protective effects of microcarriers, cells in the patterned structures maintain high activity. Subsequently, tissue-engineered cartilage constructs are obtained by inducing cell differentiation of the patterned structures. Comprehensive evaluations are conducted to verify chondrocyte differentiation and the formation of cartilage tissue constructs in terms of cell viability, morphological analysis, gene expression, and matrix production. Finally, implantation studies with a rat cartilage defect model demonstrate that these tissue-engineered cartilage constructs are beneficial for the repair of articular cartilage damage in vivo. This study provides the first biofabrication of cartilage tissue constructs using Faraday wave bioassembly, extending its application to engineering tissues with a low cell density.
P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
Authors: Shuang-Ying Wang, Yi Cai, Xiao Hu, Fei Li, Xin-Hang Qian, Ling-Yun Xia, Bo Gao, Lan Wu, Wen-Zhong Xie, Jia-Min Gu, Tong Deng, Cong Zhu, Hai-Chang Jia, Wan-Qi Peng, Jiao Huang, Cheng Fang, Xian-Tao Zeng
Journal: Military Medical Research (2024)

Abstract Background Benign prostatic hyperplasia (BPH) is the most common disease in elderly men. There is increasing evidence that periodontitis increases the risk of BPH, but the specific mechanism remains unclear. This study aimed to explore the role and mechanism of the key periodontal pathogen Porphyromonas gingivalis ( P. gingivalis ) in the development of BPH. Methods The subgingival plaque (Sp) and prostatic fluid (Pf) of patients with BPH concurrent periodontitis were extracted and cultured for 16S rDNA sequencing. Ligature-induced periodontitis, testosterone-induced BPH and the composite models in rats were established. The P. gingivalis and its toxic factor P. gingivalis lipopolysaccharide ( P.g -LPS) were injected into the ventral lobe of prostate in rats to simulate its colonization of prostate. P.g -LPS was used to construct the prostate cell infection model for mechanism exploration. Results P. gingivalis , Streptococcus oralis , Capnocytophaga ochracea and other oral pathogens were simultaneously detected in the Pf and Sp of patients with BPH concurrent periodontitis, and the average relative abundance of P. gingivalis was found to be the highest. P. gingivalis was detected in both Pf and Sp in 62.5% of patients. Simultaneous periodontitis and BPH synergistically aggravated prostate histological changes. P. gingivalis and P.g -LPS infection could induce obvious hyperplasia of the prostate epithelium and stroma (epithelial thickness was 2.97- and 3.08-fold that of control group, respectively), and increase of collagen fibrosis (3.81- and 5.02-fold that of control group, respectively). P. gingivalis infection promoted prostate cell proliferation, inhibited apoptosis, and upregulated the expression of inflammatory cytokines interleukin-6 (IL-6; 4.47-fold), interleukin-6 receptor-α (IL-6Rα; 5.74-fold) and glycoprotein 130 (gp130; 4.47-fold) in prostatic tissue. P.g -LPS could significantly inhibit cell apoptosis, promote mitosis and proliferation of cells. P.g -LPS activates the Akt pathway through IL-6/IL-6Rα/gp130 complex, which destroys the imbalance between proliferation and apoptosis of prostate cells, induces BPH. Conclusion P. gingivalis was abundant in the Pf of patients with BPH concurrent periodontitis. P. gingivalis infection can promote BPH, which may affect the progression of BPH via inflammation and the Akt signaling pathway.