tbuckley/cabot-search huggingface dataset:
Abstract 2791: Silent Brain Infarction Predicts Cardiovascular Events And Mortality In Long-term Hemodialysis Patients
Authors: Toru Aoyama, Hideki Ishii, Hiroshi Takahashi, Takanobu Toriyama, Toru Aoyama, Kyosuke Takeshita, Tatsuaki Matsubara, Toyoaki Murohara
Journal: Circulation (2007)

Background: The cardiovascular (CV) events and mortality are significantly higher in hemodialysis (HD) patents compared to the general population. Although it is of clinical concern to predict the occurrence of CV events in long-term HD patients, more powerful predictor has under exploration. We investigated as to whether silent brain infarction (SBI) would be a predictable factor for future CV events and mortality in a large cohort of patients with long-term HD patients. Methods: After cranial magnetic resonance imaging to detect SBI, 202 long-term HD patients (7.1 ± 5.9 years) without symptomatic stroke were prospectively followed up until the incident of CV events (stroke, cardiac events, and death). We analyzed the prognostic role of SBI in CV events with the Kaplan-Meier method and Cox proportional hazards analysis. Results: The prevalence of SBI was quite higher compared to the previous reports (71.8% in all the patients). In overall patients, 60 patients suffered from CV disease (31 for coronary artery disease, 7 for congestive heart failure, 14 for symptomatic stroke) and 29 patients died (16 for CV death) during a follow up period (mean= 23 ± 13 months). In subgroup analysis regarding the presence of SBI, CV event-free survival rate for 4 years was significantly lower in the patients with SBI compared to those without SBI (54.6% vs. 86.7%, p=0.0003). CV and overall mortality were also significantly higher in SBI patients compared with No-SBI patients (CV mortality; 20.5 % vs. 4.3 %, overall mortality; 29.0% vs. 9.1% p&lt; 0.01, respectively). Cox proportional hazards models showed that the presence of SBI was a significant predictor of cerebrovascular and CV events and CV and overall mortality even after adjustment for other CV risk factors listed on the Table . Conclusion: SBI detected with MRI would be powerful predictor of CV events and mortality in long-term HD patients. Hazard ratio (HR) of SBI for future events and mortality
Thiopurine methyl transferase activity predicts both toxicity and clinical response to azathioprine in inflammatory bowel disease: The London IBD forum prospective study
Authors: A Ansari, M Arenas, J Lindsay, D Morris, S Greenfield, T Khanbai, F Fong, Z Aslam, L Fairbanks, A Marinaki, J Duley, J Sanderson
Journal: Gut (2004)
2-Year Outcomes in Patients Undergoing Surgical or Self-Expanding Transcatheter Aortic Valve Replacement
Authors: Michael J. Reardon, David H. Adams, Neal S. Kleiman, Steven J. Yakubov, Joseph S. Coselli, G. Michael Deeb, Thomas G. Gleason, Joon Sup Lee, James B. Hermiller, Stan Chetcuti, John Heiser, William Merhi, George L. Zorn, Peter Tadros, Newell Robinson, George Petrossian, G. Chad Hughes, J. Kevin Harrison, Brijeshwar Maini, Mubashir Mumtaz, John V. Conte, Jon R. Resar, Vicken Aharonian, Thomas Pfeffer, Jae K. Oh, Hongyan Qiao, Jeffrey J. Popma
Journal: Journal of the American College of Cardiology (2015)
Abstract 167: Possible New Application of HTK Solution to Protect Cardiac Arrest--Induced Brain Injury After Cardiopulmonary Resuscitation
Authors: Yih-Sharng Chen, Ming-Chieh Ma
Journal: Circulation (2014)

Background: The cardioplegic solution, histidine-ketoglutarate-tryptophan (HTK), is a preservative solution for organ transplantation. Here we tested whether HTK may protect neurons against poor oxygen-induced cell damage and thus alleviate ischemic injury in brain after CA. Methods: The CA-mediated brain damage was induced by stop of ventilation for 4 min 30 sec (4’30’’) or 6 min 30 sec (6’30’’), and followed by manual CPR and epinephrine. HTK (200 μl) was given into brain via left carotid arterial catheter after CA. The sterile saline was given as controls. Neurological deficit scoring for motor function and mortality were evaluated on day 0 to 3 during recovery. The neuronal-like NG108-15 cells were applied and exposed to 2% oxygen or H2O2 to induce severe hypoxic (SH) injury or cytotoxicity in the presence or absence of HTK. Cell viability was assayed by the release of lactate dehydrogenase (LDH). Changes in caspase-3 activity for cell death were evaluated. Results: Compared with the 6’30’’ CA groups, the 4’30’’ groups had higher survival rates despite either in saline- or HTK-treated rats after 3-day CA (5/8 of 4’30’’ vs. 4/15 for 6’30’’ in saline-treated groups; 6/8 of 4’30’’ vs. 4/9 for 6’30’’ in HTK-treated groups). Neurological scores were significantly improved by HTK on day 1 for the 4’30’’ groups and days 1-3 for the 6’30” group. Most of improvements in the HTK-treated rats were related to increases in level of conscious, corneal reflex, righting reflex, motor coordination, movement activity but not respiration. Compared to the untreated NG108-15 cells, replacement of culture medium with HTK attenuated SH- and H2O2- mediated cytotoxicity in a volume- and time-dependent manner. Interestingly, these effects were associated with reduction of caspase-3 activation. Conclusion: These results suggest HTK is also an effective neuroprotective solution to protect neuron against hypoxia and treat CA-induced brain dysfunction via the mechanism of caspase-3 inhibition.
Characterization of B cells infiltrating human breast cancer and their presence in peritumoral tertiary lymphoid structures
Authors: Soizic Garaud, Laurence Buisseret, Chunyan Gu-Trantien, Edoardo Migliori, Jean Nicolas Lodewyckx, Hugues Duvillier, Ligia Ioana Ruscas-Craciun, Denis Larsimont, Karen Willard-Gallo
Journal: Cancer Research (2014)
Abstract 13950: Angioedema as an Adverse Event of Renin-Angiotensin-System Inhibitors - A Meta-Analysis of Randomized Trials
Authors: Harikrishna Makani, Jorge Romero, Arpit Shah, Ingit Parmar, Hetal Makwana, Franz H Messerli
Journal: Circulation (2011)

Background: Angioedema is a rare, potentially life threatening adverse event of renin angiotensin system (RAS) inhibitors. The objective of the present study was to determine the risk of angioedema...
Time to Live: Adventures in the Use of Leisure.
Authors: Gove Hambidge
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4141: Prevalence and Components of the Metabolic Syndrome in Peruvian Andean Mestizos: The PREVENCION Study
Authors: Julio A Chirinos, Josefina E Medina Lezama, Humberto Zea Diaz, Oscar L Morey Vargas, Juan F Bolanos Salazar, Sheyla Paredes Diaz, Mauricio Postigo Mac Dowall, Edgar Munoz Atahualpa, Paola Villalobos Tapia, Fernando Corrales Medina, Zoila Valdivia Ascuna, Carolina Cuba, Julio Chirinos Pacheco
Journal: Circulation (2006)
Abstract 4181: The Age and Gender Related Patterns of Insulin Resistance in UK Indian Asians and Northern Europeans: the London Life Sciences Population (LOLIPOP) Study
Authors: John C Chambers, Eric Lim, Paul Elliott, James Scott, Jaspal S Kooner
Journal: Circulation (2006)

Background Insulin resistance is a risk factor for cardiovascular disease (CVD). Previous studies have demonstrated that insulin resistance is more common in Indian Asians (IA) compared to Northern Europeans (NE). We report the age and gender related prevalence of insulin resistance, and related metabolic disturbances among IA and NE in the London Life Sciences Population (LOLIPOP) Study. Methods The LOLIPOP study is a population based study of IA and NE men and women aged 35–75 years, identified from the lists of 58 primary care physicians in West London. To date 19,272 participants (IA: 8791 male, 4013 Female; NE: 4346 male, 2122 female) have been recruited, with a response rate of 61%. Clinical and anthropometric data and measurements of fasting insulin, glucose, triglycerides and HDL cholesterol were recorded for each subject. Metabolic Syndrome (MS) was defined using Adult Treatment Panel III criteria. Results Waist-hip ratio, fasting insulin, glucose and triglycerides were higher, and HDL cholesterol lower, amongst IA compared to NE (all P&lt;0.001). Blood pressure was similar in IA and NE. The prevalence of MS was higher in IA than NE at each age studied (Figure ). Compared to NE, the age-adjusted prevalence of metabolic syndrome was 41% greater in IA men and 140% greater in IA women. Conclusions Our results show striking differences in age and gender related disturbances of insulin action in IA compared with NE. MS appears to develop almost 10 years earlier amongst IA men, and 20 years earlier amongst IA women, compared to NE men and women respectively. Follow-up of this cohort will help to determine the extent to which these differences contribute to higher cardiovascular events in IA.
Abstract 1503: Knockdown of Mog1 Expression Reduces Sodium Currents by Reducing the Trafficking of Cardiac Sodium Channel Na <sub>V</sub> 1.5 to the Cell Membrane
Authors: Susmita Chakrabarti, Sandro Yong, Shin Yoo, Ling Wu, Qing Kenneth Wang
Journal: Circulation (2008)

The cardiac sodium channel (Na v 1.5) plays a significant role in cardiac physiology and leads to cardiac arrhythmias and sudden death when mutated. Modulation of Na v 1.5 activity can also arise from changes to accessory subunits or proteins. Our laboratory has recently reported that MOG1, a small protein that is highly conserved from yeast to humans, is a co-factor of Na v 1.5. Increased MOG1 expression has been shown to increase Na v 1.5 current density. In adult mouse ventricular myocytes, these two proteins were found to be co-localized at the intercalated discs. Here, we further characterize the regulatory role of MOG1 using the RNA interference technique. Sodium current was recorded in voltage-clamp mode from a holding potential of −100 mV and activated to −20 mV. In 3-day old mouse neonatal ventricular cells transfected with siRNA against mouse MOG1 decreased sodium current densities (pA/pF) compared to control or scramble siRNA treated cells (−10.2±3.3, n=11 vs. −165±16, n=20 or −117.9±11.7, n=11). A similar reduction in sodium current was observed in mammalian expression system consisting of HEK293 cells stably expressing human Na v 1.5, by transfecting siRNAs against either human or mouse MOG1 (−41.7±8.3, n=7 or, −82.6±9.6, n=7 vs. −130.6±11.5, n=7; −111.5±8.5, n=7, respectively). Immunocytochemistry revealed that the expression of MOG1 and Na v 1.5 were decreased in both HEK and neonatal cells when compared to scramble siRNAs or control groups. These results show that MOG1 is an essential co-factor for Na v 1.5 by way of a channel trafficking. Such interactions between MOG1 and Na v 1.5 suggest that early localization of MOG1 on the membrane of neonatal cardiomyocytes may be necessary for proper localization and the distribution of Na v 1.5 during cardiac development. This research has received full or partial funding support from the American Heart Association, AHA National Center.
Exclusive Interview With
Authors: László Mádi-Szabó
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Study's results do not apply to norgestimate
Authors: R J Donnelly
Journal: BMJ (1996)

EDITOR,—The issue of the BMJ published on 13 January contains two papers, an editorial, and two other items in which “third generation” oral contraceptives are discussed. At times third generation oral contraceptives are referred to as those containing gestodene, desogestrel, or norgestimate; at other times they are referred to as those …
Natural History of Rheumatic Fever and Rheumatic Heart Disease
Authors: A H MCCALLUM
Journal: BMJ (1965)

This is the 10-year report of the United Kingdom and the United States and Canadian co-operative clinical trial which was conducted in 1951-2 and designed to compare the relative merits of A.C.T.H., cortisone, and aspirin in the treatment of rheumatic fever and their effects upon the evolution of rheu- matic heart disease.Over a period of approximately a year and a half, and under closely defined diagnostic criteria, 497 children under the age of 16 were admitted to the trial in 12 centres in the United Kingdom, the United States, and Canada.They were allocated at random to one or another of the three agents under investigation, and treated according to a specified plan for six weeks.After a further three weeks of detailed observation they were followed up at defined intervals.Full details of the plan of study were given in an earlier publication.'Two reports, at one year' and at five years,2 have been published.The first report compared the three treatment groups in detail throughout the six weeks of treatment, three succeeding weeks of observation, and at the end of a further year of follow-up.It was concluded that there was no evidence that any of the three agents resulted in uniform termination of the disease, and that on each agent some patients developed fresh manifestations during treatment.Treatment with either of the hormones resulted in more prompt control of certain acute manifestations, but this more rapid disappearance was balanced by a greater tendency for the acute manifestations to reappear for a limited period upon cessation of treatment.Con-
Use of gemcitabine plus vinorelbine (GV) to treat advanced and metastatic non-small cell lung cancer (NSCLC) in second line after recurrent disease
Authors: M. B. Gamaz, K. Bouzid
Journal: Journal of Clinical Oncology (2009)

e19104 Background: Docetaxel is approved as second-line monotherapy in advanced NSCLC. In this study, we evaluate the efficacy, safety and survival of gemcitabine + vinorelbine in patients with advanced NSCLC previously treated with platine salts + taxane. Methods: From January 2007 to October 2008, twenty three patients with NSCLC stage IIIB or IV who received platine salts + taxane in first line were treated in second line with (GV) gemcitabine (G) 1,250 mg/m 2 D1 and D8 + vinorelbine (V) 25 mg/m 2 D1 and D8 every three weeks. Twenty one male and 2 female, median age was 59.3 (range 40 -71) years. Twelve (12) patients had IIIB stage and 11 patients had IV stage disease. Squamous cell cancer was found in 12 patients, adenocarcinoma in 11 patients. Results: No objective response were observed, stable disease was achieved in 7 (30.4 %) patients, and disease progression was observed in 16 (69.5 %) patients. Toxicities grade ¾ was 15 %, mainly hematological (leucopenia and anemia). Median follow up was 14 months, median TTP was 6 months and median survival was 7.1 months. Conclusions: Gemcitabine + Vinorelbine could be another alternative for treatment of NSCLC in second line after recurrent disease when first line chemotherapy is platine + docetaxel. No significant financial relationships to disclose.
Biased Exposure–Health Effect Estimates from Selection in Cohort Studies: Are Environmental Studies at Particular Risk?
Authors: Marc G. Weisskopf, David Sparrow, Howard Hu, Melinda C. Power
Journal: Environmental Health Perspectives (2015)

The process of creating a cohort or cohort substudy may induce misleading exposure-health effect associations through collider stratification bias (i.e., selection bias) or bias due to conditioning on an intermediate. Studies of environmental risk factors may be at particular risk.We aimed to demonstrate how such biases of the exposure-health effect association arise and how one may mitigate them.We used directed acyclic graphs and the example of bone lead and mortality (all-cause, cardiovascular, and ischemic heart disease) among 835 white men in the Normative Aging Study (NAS) to illustrate potential bias related to recruitment into the NAS and the bone lead substudy. We then applied methods (adjustment, restriction, and inverse probability of attrition weighting) to mitigate these biases in analyses using Cox proportional hazards models to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).Analyses adjusted for age at bone lead measurement, smoking, and education among all men found HRs (95% CI) for the highest versus lowest tertile of patella lead of 1.34 (0.90, 2.00), 1.46 (0.86, 2.48), and 2.01 (0.86, 4.68) for all-cause, cardiovascular, and ischemic heart disease mortality, respectively. After applying methods to mitigate the biases, the HR (95% CI) among the 637 men analyzed were 1.86 (1.12, 3.09), 2.47 (1.23, 4.96), and 5.20 (1.61, 16.8), respectively.Careful attention to the underlying structure of the observed data is critical to identifying potential biases and methods to mitigate them. Understanding factors that influence initial study participation and study loss to follow-up is critical. Recruitment of population-based samples and enrolling participants at a younger age, before the potential onset of exposure-related health effects, can help reduce these potential pitfalls.Weisskopf MG, Sparrow D, Hu H, Power MC. 2015. Biased exposure-health effect estimates from selection in cohort studies: are environmental studies at particular risk? Environ Health Perspect 123:1113-1122; http://dx.doi.org/10.1289/ehp.1408888.
The Blood Picture and Its Clinical Significance (Including Tropical Diseases): A Guidebook on the Microscopy of Blood.
Authors: Victor Schilling
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug points: High fever induced by sulphasalazine
Authors: S D Hearing, S Playfor, S J Bentley
Journal: BMJ (1995)

Drs S D HEARING, S PLAYFOR, and S J BENTLEY (Warrington Hospital, Warrington WA5 1QG) write: We report a case of high fever induced by sulphasalazine.

A 42 year old white woman with a two year history of rheumatoid arthritis presented with a high fever and constitutional illness. Ten days before admission she …
Identifying An Optimally Effective But Tolerable Dose Of Bendamustine In Combination With Thalidomide and Dexamethasone In Patients With Relapsed Or Refractory Multiple Myeloma
Authors: Stephen A Schey, Kwee L Yong, Cathy D. Williams, Faith E Davies, Gareth J Morgan, James D. Cavenagh, Gordon Cook, Mark Cook, Avie-Lee Coney, Sarah Brown, Louise M Flanagan, Walter Gregory, Jim Cavet
Journal: Blood (2013)
Medical Diagnosis for the Student and Practitioner.
Authors: Charles Lyman Greene
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fortschritte der Naturwissenschaftlichen Forschung.
Authors: Emil Abderhalden
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal