tbuckley/cabot-search huggingface dataset:
Abstract 5669: Brugada Syndrome: The Absence of Symptoms is a Poor Predictor of Identifying Individuals at Risk of Sudden Death
Authors: Michael Papadakis, Carey Edwards, John C Rawlins, Sanjay Sharma
Journal: Circulation (2008)

Risk stratification for sudden death in Brugada syndrome and hence indications for implantation of an internal cardioverter defibrillator are based on the presence of a spontaneous type 1 electrocardiogram (ECG) pattern, in association with unheralded syncope or documented polymorphic ventricular tachycardia. Increasingly, awareness of sudden death in the young and implementation of pre-participation screening programs in sport will identify young, asymptomatic patients with the Brugada phenotype. We evaluated the predictive accuracy of symptoms, particularly unheralded syncope in victims of sudden death from Brugada syndrome. Over the past 3 years we identified 22 victims of sudden cardiac death secondary to Brugada syndrome. The diagnosis was based on sudden death with normal findings at post mortem and the identification of the type 1 Brugada ECG pattern in first-degree relatives (spontaneous or following ajmaline provocation test). All relatives underwent 12-lead ECG, echocardiography, exercise testing, 24-hour Holter monitor and biochemical tests. Cardiac magnetic resonance imaging and coronary angiography were performed when appropriate. Of the victims dying from Brugada syndrome, 15 (68%) were male. The mean age of sudden death was 30 years (range 8 –56 years) and 95% died suddenly at rest or during sleep. We interviewed first-degree relatives and partners regarding prodromal symptoms or a history of epilepsy. Only 3 out of 22 victims (14%) had significant symptoms. Specifically, 2 individuals experienced unheralded syncope and 1 suffered nocturnal seizures. Only 14% had a family history of premature sudden cardiac death. Indeed we obtained 12-lead ECGs in 3 victims taken less than 6 months prior to sudden death, which failed to reveal the typical Brugada ECG phenotype. Our results indicate that the vast majority of individuals who die from Brugada syndrome in the UK are asymptomatic and raise concerns that the absence of symptoms does not necessarily mean low risk. Better understanding of the disorder and risk stratification protocols is necessary to permit genuine reassurance in asymptomatic individuals exhibiting the Brugada phenotype.
Abstract 423: Reduction of Wasted Left Ventricular Contractility During Right Ventricular Septal Pacing in Comparison With Apical Pacing
Authors: Katsuji Inoue, Hideki Okayama, Kazuhisa Nishimura, Takayuki Nagai, Jun Suzuki, Akiyoshi Ogimoto, Tomoaki Ohtsuka, Makoto Saito, Go Hiasa, Toyofumi Yoshii, Takumi Sumimoto, Junichi Funada, Jitsuo Higaki
Journal: Circulation (2009)
Abstract 1539: ERK Signalling is Necessary for BMP-4 Dependent Capillary Sprouting and is Controlled by a Negative Feedback Loop Involving Smad6
Authors: Qian Zhou, Alberto Vargas, Fabian Klumpp, Stephan Winnik, Tobias Krauss, Christoph Bode, Cam Patterson, Martin Moser
Journal: Circulation (2006)

Bone Morphogenetic Protein-4 (BMP-4) has a wide range of biological activities on vascular development and differentiation. Classically, BMPs mediate signals through the Smad pathway. During mouse ...
Abstract 18647: Gender Differences in the Relationship Between Depressive Symptoms and Coronary Events in Acute Coronary Syndrome Patients
Authors: Jennifer E Sanner, Alanna Morrison, Lorraine Frazier
Journal: Circulation (2013)

Background: Despite a decrease in acute mortality, a considerable number of patients who have acute coronary syndrome (ACS) go on to experience major adverse coronary events (MACE). The objectives of this prospective ACS study are to examine relationships between depressive symptoms and risk of subsequent MACE and most importantly, examine if gender differences exist. We hypothesized that the presence of depressive symptoms will be related to increased risk of MACE and gender differences will exist. METHODS: We analyzed 1194 patients enrolled during hospitalization for ACS. Patients were screened using the Beck Depression Inventory-II. Annual telephone interviews were conducted to obtain MACE data. MACE was defined and death, stroke, AMI, re-admission for ACS requiring vascularization. Basic descriptive statistics were determined and analysis of risk for MACE was conducted with logistic regression. Logistic regression models for occurrence of MACE included gender and depression as the independent variables. An interaction term for gender-by=depression was included in the model to test if the association of depression and MACE varies by gender. RESULTS: Of the 1104 with MACE data, 16% reported MACE. Of those, 33% were women and 67% were men. Women were older (64.19 ± 13) than men (61.06 ± 11.60) (p&lt;0.0001) and were more likely to report a diagnosis history of diabetes (p=0.009), hypertension (p&lt;0.0001), and stroke (p=0.005) than men. Men were more likely to report current smoking (p&lt;0.0001) and alcohol (p&lt;0.0001) statuses than women and were more likely to report a history of coronary angioplasty (p=0.001). Depressive symptoms were significantly related to MACE with a two-fold greater odds of subsequent MACE (OR 2.56, CI 1.80-3.63, p=&lt;0.0001). Both men (OR 2.82, CI 1.85-4.28, p&lt;0.0001) and women (OR 2.09, CI 1.12-3.91, p=0.020) experience greater odds of MACE when depressed. The association between depression and MACE did not vary significantly by gender (p=0.394). CONCLUSIONS: To conclude important gender differences were noted, but the association between depression and MACE did not vary significantly by gender. This study has the potential to add to the growing body of literature that suggests that gender-related differences exist with regard to ACS.
Abstract 187: Autophagy in the Myocardium of Mice Subjected to Ischemia Followed by Reperfusion
Authors: Christopher J French, Douglas J Taatjes, Burton E Sobel
Journal: Circulation (2010)

Introduction: Autophagy has been thought by many to be cardioprotective, but its extent early after myocardial ischemic insults remains unclear. We characterized the magnitude of early autophagy in...
Abstract 17761: Long-term microRNA-29b Suppression Prevents Aneurysm Development in Marfan Syndrome Model Mouse
Authors: Homare Okamura, Fabian Emrich, Alex Dalal, Andrew Connolly, Michael Fischbein
Journal: Circulation (2013)

Objective: Aortic aneurysm and subsequent rupture is the life threatening complication in Marfan syndrome, genetic systemic connective tissue disorder. miR-29b, one of microRNAs, has been reported ...
Abstract 165: Airway-Circulation-Leadership-Support (A-C-L-S) Team Training Model Improved Resuscitation Quality and Self-Perceived Team Efficacy Among Paramedics
Authors: Kuan-Chen Chin, Chih-Wei Yang, Kah-Meng Chong, Cheng-Yi Wu, Eric Hao-Chang Chou, Huang-Fu Yeh, Nai-Chuan Chen, Shih-Hung Liu, Wei-Ting Chen, Hui-Chih Wang, Wen-Chu Chiang, Patrick Chow-In Ko, Matthew Huei-Ming Ma
Journal: Circulation (2012)

INTRODUCTION The updated guidelines for advanced life support emphasize providers should coordinate and perform resuscitation in a team-based approach. A model called A-C-L-S was developed and our ...
Abstract 20205: Patients with Severe Chronic Kidney Disease have Survival Benefit from Initial Invasive Therapy and Early Revascularization after Acute Coronary Syndrome
Authors: Henry D Huang, Mahboob Alam, Anita Deswal, Salim S Virani, David Aguilar, Gabriel Habib, Biykem Bozkurt, Hani Jneid
Journal: Circulation (2010)

Background: Early invasive strategy and revascularization are associated with improved outcomes after acute coronary syndrome (ACS). It is unclear whether their benefits persist in ACS patients wit...
P0646 : Lower risk of hepatocellular carcinoma in chronic hepatitis B patients treated with entecavir: A reach-B analysis of the enumerate study
Authors: J. Ahn, M. Nguyen, H. Lee, J. Lim, C. Pan, H. Te, T. Tran, H.N. Trinh, D. Lau, D. Chu, A. Min, T.-S. Leduc, A. Pillai, H. Bae, S. Do, A. Mannalithara, A.S. Lok, W.R. Kim
Journal: Journal of Hepatology (2015)
No association between low cholesterol and violent death
Authors: T. Strandberg
Journal: BMJ (1995)

promote contraception through safer sex cam- paigns have undoubtedly been successful in increasing the proportion of teenagers who use condoms.Most people have assumed that increas- ing the use of contraception leads to a reduction in unplanned teenage pregnancies.4Yet my analysis shows that this has not happened.A plausible explanation is that the main factor in unplanned teenage conceptions is contraceptive failure, not the lack of contraceptive knowledge and availability.The findings of Pearson and colleagues support this view.A further question is whether increasing the availability of contraception leads to an increase in sexual activity.If this is the case-and the national survey of sexual behaviour reports a large increase over the past two decades in the proportion of teenagers who are sexually active-then it is not surprising that the rate of teenage conceptions continues to increase.The answer is not more contraception or emergency contraception but a change in attitude towards sexual behaviour.
Abstract 4449: Impact of High Loading and Maintenance Dose of Clopidogrel within the First 15 Days after Percutaneous Coronary Intervention on Early Patient Outcome
Authors: Gilles Lemesle, Cedric Delhaye, Arnaud Sudre, Guillaume Rosey, Damien Broucqsault, Christophe Bauters, Jean-Marc Lablanche
Journal: Circulation (2008)

An increase in clopidogrel dose results in an improved inhibition of platelet aggregation. However, whether an increase in clopidogrel dose may improve patient outcome is still debated. The aim of ...
Hyperthyroidism and propylthiouracil-induced agranulocytosis during chronic lithium carbonate therapy
Authors: L J Valenta, A N Elias, D J Weber
Journal: American Journal of Psychiatry (1981)

The authors describe the case of a 49-year-old woman who developed a goiter, mild symptoms of hyperthyroidism, and grossly elevated thyroid function tests after 2 years of treatment with lithium carbonate. Thyroid microsomal autoantibodies were also present. She was retreated with propylthiouracil and improved, but within 3 months she developed agranulocytosis. Propylthiouracil was discontinued, and the patient was treated with antibiotics and recovered. She was then given 131I to control her hyperthyroidism. The case is an example of the rare association of hyperthyroidism with lithium, which usually suppresses thyroid function, and demonstrates that lithium carbonate cannot prevent agranulocytosis caused by propylthiouracil.
Abstract 21546: Protein Phosphatase 1 Regulates Normal Automaticity of the Heart's Pacemaker Node Cells by Site-specific Modulation of Phospholamban Phosphorylation that Regulates Spontaneous Subsarcolemmal Local Ca2+ Releases
Authors: Ihor Zahanich, Yue Li, Alexey E Lyashkov, Yevgeniya O Lukyanenko, Tatiana M Vinogradova, Antoine Younes, Edward G Lakatta
Journal: Circulation (2010)

The heart's rhythm is driven by spontaneous action potential (AP) firing of sinoatrial node cells (SANC), in which cAMP-mediated, PKA-dependent local subsarcolemmal Ca2+ releases (LCRs) play a crucial role. SANC sarcomplasmic reticulum (SR) has been referred to as an intracellular ”Ca2+ clock” because it generates spontaneous periodic submembrane Ca2+ oscillations controlled by phosphorylation of phospholamban (PLB). Protein kinase A (PKA) and the Ca2+/calmodulin-dependent protein kinase II (CAMKII) regulate PLB by phosphorylation at Ser16 and Thr17 sites. We aimed to determine how protein phosphatase (PP) activity is involved in regulation of PLB phosphorylation, LCR generation and spontaneous rhythmic AP firing of SANC. In freshly isolated rabbit SANC, the PP1/2A inhibitor calyculin A (CyA), 100–500 nM, increased the spontaneous SANC beating rate, recorded using perforated patch, by 24–30%, from 179.4±13.1 to 230.6±7.45 beat/min (n=21). Confocal Ca2+ imaging of isolated SANC demonstrated that PP inhibit...
Operative Obstetrics, Including the Surgery of the New-Born.
Authors: L. I. Breitstein
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Complex partial and pseudoseizure disorders
Authors: R A Remick, J A Wada
Journal: American Journal of Psychiatry (1979)

The differentiation of ictal and nonictal seizure disorders is difficult, particularly in patients suffering from partial seizures with complex symptomatology. The authors state that observation of a patient's habitual seizure during EEG recording is the ideal diagnostic tool and describe their method of seizure activation with sphenoidal electrodes and simultaneous audiovisual monitoring. They emphasize the necessity for early, aggressive treatment of both ictal and nonictal seizure disorders, point out risks to the patient if the incorrect diagnosis is made, and urge further cooperation between psychiatrists and neurologists in this borderland area.
Patterns of Disease Recurrence after SABR for Early Stage Non–Small-Cell Lung Cancer: Optimizing Follow-Up Schedules for Salvage Therapy
Authors: Naomi E. Verstegen, Frank J. Lagerwaard, Sayed M.S. Hashemi, Max Dahele, Ben J. Slotman, Suresh Senan
Journal: Journal of Thoracic Oncology (2015)
Non-small cell lung cancer treatment by inhalation of Erbitux and gemcitabine in murine model
Authors: Yehuda Schwarz, Ofer Merimsky, Alex Starr
Journal: European Respiratory Journal (2011)

We evaluate the efficacy of chemotherapy delivered by inhalation in murine model of lung cancer.   Methods:  Mouse models of human (H226) and murine (3LL) non-small cell lung cancer (NSCLC) were use. Cultivated human NSCLC cells were inoculated orthotopically into the lung (H226) or intravenously (3LL) producing advanced disseminated lung cancer. Aerosols were delivered daily from day 5 to day 30 (after tumor cell inoculation) using an ultrasonic nebulizer in a cage specially constructed to in total dosage 30mg/kg (Erbitux) and 0.5mg/kg (Gem). The effect of nebulization on Erbitux was assessed in terms of its affinity for membrane EGFR (using ELISA), inhibition of cell growth (XTT assay) and inhibition of EGFR phosphorylation (by immunoprecipitation).   Results:  Significant inhibition of tumor growth by Erbitux alone or in combination with Gem was observed. Inhalation of Erbitux in 3LL resulted in 50% reduction of lung weights and number of tumor nodules. Nebulized Gem demonstrated 80% decrease in the lung weights and tumor foci whereas combination therapy resulted in complete disappearance of tumor masses. Inhalation in H226 with Erbitux demonstrated 10% reduction of lung weight, 40% reduction with Gem and 50% with combination therapy. Inhalations were well tolerated without toxicity to lungs, kidney, colon, skin, liver or spleen.   Conclusions:  We demonstrated an efficacy of the aerosol treatment by Erbitux and Gem in animal model of NSCLC without any pulmonary toxicity. The study demonstrated therapeutic perspective of aerosol delivery of Erbitux/Gem in the treatment of patients with advanced disseminated lung cancer.
Comparison of the use of cefepime (cefp) monotherapy vs. piperacillin/tazobactam (pip/tazo) plus a fluroquinolone or aminoglycoside for the empiric treatment of febrile neutropenia (FN)
Authors: S. Gordon, E. Stuntebeck, C. Collins, D. Streetman, A. Ward, H. Erba
Journal: Journal of Clinical Oncology (2006)

18581 Background: Practice guidelines for empiric therapy of FN were created and implemented at our institution in January 2003, prior to which empiric therapy often included the use of cefp. These guidelines recommend the combination of pip/tazo with gentamicin or levofloxacin for most patients. This retrospective chart review compared the efficacy of pip/tazo combination therapy versus historical controls treated with cefp. Methods: 183 patients met eligibility criteria. 87 patients were treated with pip/tazo, with 92% receiving levofloxacin as the second agent. 75 patients received cefp, 16 of which initially also received either a fluoroquinolone or an aminoglycoside. Endpoints included a difference in the addition of vancomycin and antifungals, incidence of breakthrough infections, trends in antibiotic resistance, and survival until discharge. Groups were compared using chi-square or Student’s t-test as appropriate. Results: The two groups were not significantly different in any measured demographic or clinical characteristic. No statistical difference was found between groups for the addition of vancomycin (cefp 43%, pip/tazo 41%; p = 0.9898) or antifungals (cefp 45%, pip/tazo 51%; p = 0.1346). The incidence of breakthrough infections was comparable (cefp 25%, pip/tazo 26%; p = 0.7461), and microorganism eradication rates were not different between groups (cefp 48%, pip/tazo 54%; p = 0.41). However, of those who developed a breakthrough infection, survival was lower in the cefp group (37% vs. 63%; p = 0.0389). Additionally, the rate of overall survival to discharge was significantly lower in patients initially treated with cefp (83% vs. 94%; p = 0.0193). The antibiograms of the hematology floors were compared for the 2 years prior to and after implementation of our FN guidelines; no change in susceptibilities was observed. Conclusions: From these results, we conclude that pip/tazo combination therapy is a reasonable alternative to cefp for empiric treatment of FN. [Table: see text]
A phase II, single-arm clinical trial involving an alternative cancer treatment psorinum therapy in patients with advanced non-small cell lung cancer (NSCLC).
Authors: A. Chatterjee, J. Biswas, A. K. Chatterjee, S. Bhattacharya, B. P. Mukhopadhyay, A. Chakraborty, S. Das, R. S. Bhakta
Journal: Journal of Clinical Oncology (2010)

2592 Background: We prospectively studied the clinical efficacy of an alternative cancer treatment "psorinum therapy" in patients with advanced non-small cell lung carcinoma (NSCLC). Methods: Our study was phase II, open- level, single arm, and single stage. Participants' eligibility criteria included (1) histopathological or cytopathological confirmation of NSCLC; (2) inoperable; (3) no prior chemotherapy or radiation therapy; (4) Karnofsky performance status between 40 and 60. The primary outcome measures of the study were (1) to assess the radiological tumor response rates (using CT scan procedure and following the RECIST criteria); (2) to assess how many participants survived at least 1 yr, 2 yrs, 3 yrs, 4 yrs, and finally, after 5 yrs ofthe study. The secondary outcome measure was to assess the side effects of the investigational anticancer drug (psorinum) if any. The drug psorinum (an alcoholic extract of scabies, scrub, slough, and pus cells) was administered orally at 0.02ml/Kg body weight/day as a single dose in empty stomach and ongoing for complete course duration of 2 years to all the participants along with allopathic and homeopathic supportive cares. Results: 95 participants included in the final analysis at the end of the study. According to the AJCC TNM staging system, 58 (61.05%) of them diagnosed at stage IV. According to the RECIST criteria, complete tumor response occurred in 19 (20%) cases and partial tumor response occurred in 28 (29.47%) cases. 82 (86.32%) of them survived at least 1 yr, 70 (73.68%) survived at least 2 yrs, 58 (61.05%) survived at least 3 yrs, 49 (51.58%) survived at least 4 yrs, and 42 (44.21%) of them survived at least 5 yrs. These participants did not receive chemotherapy, radiation therapy, or any other investigational cancer treatments. Participants reported no side effects from the drug psorinum. Conclusions: The results of this study show clinical efficacy of psorinum therapy in treating patients with advanced NSCLC. The investigational drug psorinum is non-toxic. Randomized double-blinded clinical trial should be conducted for further investigation of this alternative cancer therapy in treating NSCLC. No significant financial relationships to disclose.
Bone Marrow and Thymus Expression of Interferon-γ Results in Severe B-Cell Lineage Reduction, T-Cell Lineage Alterations, and Hematopoietic Progenitor Deficiencies
Authors: Howard A. Young, Dennis M. Klinman, Della A. Reynolds, Krzysztof J. Grzegorzewski, Aisuke Nii, Jerrold M. Ward, Robin T. Winkler-Pickett, John R. Ortaldo, James J. Kenny, Kristin L. Komschlies
Journal: Blood (1997)
Abstract 19391: Activation of AMP-activated Protein Kinase Displays a Novel Strategy Against Reperfusion-Induced Barrier Failure in Endothelial Cells
Authors: Frauke V Härtel, Assad M Riaz, Muhammad Aslam, Dursun Gündüz, Thomas Noll
Journal: Circulation (2010)

Background:  Capillary leakage and edema formation is a complication of ischemia compromising the outcome of reperfusion and the recovery of heart function. Recently it became apparent that the AMP-activated protein kinase (AMPK) not only plays a crucial role as a fuel sensor during hypoxia but also is involved in stabilizing endothelial barrier function. Here we tested the hypothesis that the imminent barrier failure induced by ischemia/reperfusion can be prevented by pharmacological activation of AMPK at the onset of reperfusion.   Methods and Results:  Cultured human umbilical vein endothelial cells (HUVEC) were exposed to ischemia (40 min, Po2   Conclusions:  AMPK is involved in the maintenance of endothelial barrier. Targeted activation of AMPK at the onset of reperfusion abolishes reperfusion-induced hyperpermeability. Therefore, activation of AMPK may be a promising new therapeutic option to prevent reperfusion-induced endothelial barrier failure.
The Novel Immunoproteasome Inhibitor PR-924: Anti-Leukemic Activity and Mechanisms Of Resistance
Authors: Denise Niewerth, Johan van Meerloo, Yehuda Assaraf, Gerrit Jansen, Tessa C Hendrickx, Christopher J. Kirk, Janet Anderl, Sonja Zweegman, Jacqueline Cloos, Gertjan Kaspers
Journal: Blood (2013)