tbuckley/cabot-search huggingface dataset:
Comparative Study of Non-Diabetic Hypertensives with Diabetic Hypertensives Patients Followed at Cardiology Clinic of National University Hospital of Fann
Authors: Momar Dioum
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

Introduction Hypertension and diabetes are two major cardiovascular risk factors. Their association is very common with the consequence of a potentiation of cardiovascular complications. The objective of this study was to compare the epidemiological, diagnostic and therapeutic aspects of non-diabetic hypertensive patients with diabetic hypertensive patients. Patients and methods We conducted a prospective, descriptive and analytical study on known non-diabetic hypertensive patients (NDHP) and diabetic hypertensive patients (DHP), who presented in consultation at the cardiology clinic of Fann hospital, during the period from April 29th to July 29th 2019. SPSS (Statistical Package for the Social Sciences) version 21 was used for data analysis. Results Our study included 50 patients in each group. We found a female predominance in both groups with a sex-ratio M/F of 0.61 in NDHP and 0.56 in NDHP. The average age of NDHP was 08 years higher (65.46 years versus 58.5 years) than that of DHP (P=0.0014). Overweight was more common in DHP 44% versus 24% (P=0.0019). History of coronary artery disease and stroke were more frequent in DHP than in NDHP with (20% versus 14%) (P=0.002) and (16% versus 10%) respectively (P=0.0069). The mean pulsed blood pressure was higher in DHP (64 versus 60 mmHg) (P=0.046). The mean total cholesterol in NDHP was higher than that of DHP (2.24±0.53 versus 2.04±0.74 g/l) (p=0.045). Repolarization disorders were more frequent in DHP (22% versus 16%) (P=0.005). Monotherapy was more used in NDHP (30% versus 14%) (P=0.002). Blood pressure balance was more frequently achieved in DHP (56% versus 34%) (P=0.04). Conclusion: Our study shows that diabetic hypertensives are a particularly at-risk population compared to non-diabetic hypertensives. Cardiovascular risk is higher and blood pressure control is lower in diabetic hypertensives compared to non-diabetic hypertensives patients.
Postcovid-19 War Era, (re-) Consideration of Enhanced Mortality and Morbidity Rate of Cardiovascular Affected Patients
Authors: Bahram Alamdary Badlou
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

Accelerated mortality phenomena (post-)covid-19 contamination is a process that could play a pivotal role in the next decades, as well [1,2]. According to a study, people who had COVID- 19 faced substantially increased risks for 20 different cardiovascular conditions, including potentially catastrophic problems such as heart attacks and strokes, in the year after infection with the COVID-19 variants.
A Case Report: Successful Cardiac Catheterization Management of Post-Glenn complete Thrombosis of the Left Pulmonary Artery and Severe SVC to RPA Anastomosis Stenosis in a 1- Year-Old Infant
Authors: M. Abdelbaki
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

The Glenn palliation is a vital step in the staged surgical management of patients with single ventricle physiology. While it offers hemodynamic improvement, certain post-operative complications can be life-threatening. Case Presentation: We report a case of a 1-year-old with single ventricle physiology, who underwent Glenn palliation and subsequently presented with severe complications, including complete thrombosis of the left pulmonary artery (LPA) and significant stenosis at the superior vena cava-right pulmonary artery (SVC-RPA) anastomotic site. The child presented clinically with profound cyanosis and features suggestive of superior vena cava syndrome. These complications were successfully managed via cardiac catheterization, with repermeabilization of the LPA and stenting of both the LPA and SVC-RPA junction.
Particularity of Coronary Artery Aneurysm Management
Authors: El Abasse Zeine
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

Aneurysmal dilation of coronary arteries is observed in up to 5% of patients undergoing coronary angiography. Due to their poorly elucidated underlying mechanisms, their variable presentations, and the lack of largescale outcome data on their various treatment modalities, coronary artery aneurysms and coronary ectasia pose a challenge to the managing clinician. This paper aims to provide a succinct review of aneurysmal coronary disease, with a special emphasis on the challenges associated with its interventional treatment.[1] Coronary artery ectasia likely represents an exaggerated form of expansive vascular remodeling in response to atheroslerotic plaque growth with atherosclerosis being the most common cause. Although, it has been described more than five decades ago, its management is still debated. We diagnosed 13 patients admitted for acute coronary syndrome, in whom coronary angiography revealed thrombotic occlusion of aneurysmal arteries.[2] double platelet antiaggregation and anticogulation therapy were associated. we found that anticoagulation treatment combined with platelet anti-aggregation treatment accelerated the disappearance of the thrombus, enabling visualization of the artery so that a decision could be made whether or not to undergo angioplasty. the aim of this article is to investigate in literature how acute coronary syndrome can be managed in aneurysmal arteries.
Pulseless Electrical Activity from an Overly Distended Bladder
Authors: Aubin Sandio
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

Acute urinary retention is a common consequence of benign prostatic hyperplasia (BPH). Usually, the obstruction is addressed before any serious consequences occur; however, vagal stimulation is a reported consequence of bladder overdistention that can lead to the classic symptoms of vasovagal reactions, including hypotension, bradycardia, and, in some instances, EKG changes. We present the case of a 92-year-old male who presented to the emergency department with a new-onset complete atrioventricular (AV) block and developed pulseless electrical activity (PEA) as a complication of acute urinary retention after a failed trial of void. (TOV).
Acute Limb Ischemia Associated with COVID-19
Authors: M. Abdelbaki
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

Coronavirus disease-19 (COVID-19) caused by SARS-CoV-2 first appeared in December 2019 in China (1) and has remained a hot topic for the past 3 years. Currently, it is considered a multi-systemic disease associating a hypercoagulable state responsible for thrombotic complications in seriously affected patients. Acute COVID-19 infection causing micro thrombi called immune thrombi. Among the complications, acute limb ischemia is rarer than coronary heart disease, which explains the absence of clear and consensual guidelines allowing cardiologists to diagnose and treat acute limb ischemia in the context of the Covid 19 pandemic.
Hydatid Cyst of the Heart: About a Series
Authors: M. Abdelbaki
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

From January 1996 to December 2019, 16 patients were hospitalized in the cardiac surgery department and operated on for hydatid cyst of the heart. The majority were female. The average age was 29 years old. 25% of patients had an associated extracardiac location. All patients underwent open heart surgery. The purpose of this study is to report our experience, assess the results and compare them with data from the literature. Doppler echocardiography and MRI angiography allowed early and precise diagnosis. The prognosis is good except in the formsComplicated. Surgery remains the only therapeutic alternative. Anti-parasitic medical treatment is a complement to surgery advocated by certain teams.
Successful Retrieval of a Dislodged Ductal Stent in a Neonate with type I Pulmonary Atresia with intact Ventricular Septum
Authors: M. Abdelbaki
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

We report a unique case of a one-day-old neonate diagnosed with pulmonary atresia type I and a hypoplastic right ventricle accompanied by a coronary cameral fistula alimented by the right ventricle cavity. An attempt was made to stent the ductus arteriosus following intolerance to Prostine perfusion and paroxysmal desaturation events. The stent unfortunately embolized into the aorta but was successfully retrieved without incident, and a subsequent stenting attempt proved successful.
The Application of Interpersonal Communication Concepts in Pastoral Care Counseling
Authors: Jim Schnell
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

This report focuses on the application of interpersonal communication concepts in pastoral care counseling. Such conceptual applications will stress perception, listening, nonverbal communication, cross-cultural dynamics, power and conflict. These conceptual orientations are, in turn, applied to pastoral care counseling contexts. These applications result in enhanced understanding for how diversity and pluralism elements are inherent within these contexts and related circumstances. This report will focus on the application of interpersonal communication concepts in pastoral care counseling. Such conceptual applications will focus on perception, listening, nonverbal communication, cross-cultural dynamics, power and conflict. These conceptual orientations will be applied to pastoral care counseling contexts. The reader will observe how diversity and pluralism elements are inherent within these applications.
Echocardiographic Study of Global Longitudinal Strain in Patients with Bipolar Disorder and Schizophrenia
Authors: Muammer Karakayali
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

Background: Cardiovascular diseases are the leading cause of death in patients with bipolar disorder (BD) and schizophrenia. Studies examining cardiac structure and function in patients with BD and schizophrenia using echocardiography and cardiac strain imaging are insufficient. Moreover, despite the proven increased burden of cardiovascular disease in psychiatric diseases such as BD and schizophrenia, there is unfortunately a gap in early preventive treatment. In this study, we aimed to use echocardiographic global longitudinal strain (GLS) to compare cardiac structure and function between patients with BD, schizophrenia, and mentally healthy adults. Methods: This study recruited 92 patients diagnosed with BD (n:47) and schizophrenia (n:45). As the control group, 53 healthy volunteers without a history of psychiatric illness were included. Transthoracic echocardiography was performed for all patients. Results: There was no difference in GLS values between patients with schizophrenia and bipolar disorder (p: 0.862). GLS values of both groups were found to be statistically significantly lower than the healthy control group (-21.7 ±1.6 vs. -15.9 ±1.5 vs. -16.1 ±1.6, p&lt;0.001). Conclusion: As a result, decreased GLS values were found in patients with psychiatric disorders compared to the healthy group in our study. Interestingly, different GLS values were also found among patients with psychiatric disorders, with statistical significance.
Survival of an Electrical Storm Secondary to Dofetilide Therapy - A Case Report
Authors: Aubin Sandio
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

The case of a 74-year-old patient who experienced an electrical storm while being admitted to the intensive unit for acute hypercapnic respiratory failure. The patient had a history of atrial fibrillation and is on dofetilide. The electrical storm was characterized by multiple runs of polymorphic ventricular tachycardia, which was believed to be secondary to the use of dofetilide and later the usage of amiodarone. The patient was treated with lidocaine infusion, ICD reprogramming, and intravenous magnesium sulfate, which resulted in the successful termination of the tachycardia. This case highlights the necessary steps in the management of an electrical storm, the possible pro-arrhythmogenic effects of anti-arrhythmia medications, and the relative frequency of electrical storms in ICD recipients.
Clinical Outcomes of Direct or Direct like Stenting in Patients Undergoing Primary Pci for Stemi
Authors: Rohit Mody
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

Background Significant Improvement in reperfusion markers is observed by direct stenting (DS) in patients with ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention. However, clinical outcomes are variable, and information on the number of patients with STEMI who can be treated with DS or direct-like stenting is lacking. Aim To determine the feasibility and clinical outcomes of DS or direct-like stenting in patients with acute STEMI Methods This single-center and retrospective clinical study analyzed data from 514 patients admitted to the hospital with STEMI from October 2016 to March 2021. Most of these patients were treated with DS or direct-like stenting, and the operator was as direct as possible in performing the procedure. The outcomes were noted at the 2-year follow-up, and the incidence of on-table complications was analyzed. Results The total motality was 11.2% and the major adverse cardiac events (MACE) were seen in 13.62% at the 2-year follow-up. The post-procedural thrombolysis in myocardial infarction grade 3 flow was achieved in &gt;86% of patients. A lower risk of edge dissection was observed. Our study revealed that DS reduced radiation exposure time, procedure time, and contrast volume used. Patients with cardiogenic shock have worst outcomes than patients with normal hemodynamics. It is a well-known fact that the cardiogenic shock patients have worst outcomes than normal hemodynamic patients. We analyzed this group of patients separately, so as to see the still better outcomes with DS in this high-risk sub-set of patients. Conclusions Study results demonstrated that DS or direct-like stenting is a quite promising method in most patients with STEMI and causes fewer on-table complications. Additionally, it supports the hypothesis that DS may result in better 2-year follow-up results.
Left Post-Traumatic Diaphragmatic Rupture with Intra-Thoracic Abdominal Organs Dislocation: A Case Report
Authors: Aubin Sandio
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

The diaphragm is a dome-shaped respiratory muscle located at the base of the chest. It originates fron the greek word “diaphragma” meaning partition. The diaphragm separates the abdominal cavity from the thoracic cavity in humans and it is also the chief muscle of respiration. Diaphragmatic rupture is a medical condition caused by blunt or penetrating trauma, which often leads to herniation of abdominal viscera into the thoracic cavity. We present the case of a 39-year-old man who came complaining of left chest pain and abdominal pain radiating to his back, after getting involved in a motor vehicle accident. On physical examination, his left thoracic rib cage was not rising with each breath, while the right thoracic ribcage did expand with each breath. There was dullness on percussion of the left lung field, and he had diffuse abdominal tenderness on palpation [1]. A chest X-Ray was performed, and it revealed that there was displacement of abdominal visceral organs into the thoracic cavity, accompanied by a collapse of the left lung most likely secondary to blunt trauma. The patient underwent exploratory laparotomy with the aim of confirming the presumptive diagnosis and repairing his diaphragmatic rupture. Diaphragmatic ruptures can only be repaired via a surgical approach. The surgical approach could be via either a laparotomy or a thoracotomy. The decision toutilize either approaches leans/ is dependent on a composite of factors which include; are there any other intra-abdominal organ abnormalities, is this an acute diaphragmatic rupture or a latent diaphragmatic rupture, is the patient hemodynamically stable or unstable, and the experience of the surgeon.
A Novel Ryanodine Receptor 2-Mutation associated with Catecholaminergic Polymorphic Ventricular Tachycardia
Authors: Malin Zaddach
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

Catecholaminergic polymorphicic ventricular tachycardia (CPVT) is a genetically determined arrhythmic disorder characterized by bidirectional and polymorphic dysrhythmias. Physical and/or emotional stress may trigger tachycardia, which can lead to sudden cardiac death. If not treated, CPVT has a high mortality rate of up to 31% by the age of 30 years. The prevalence of CPVT is estimated to be 1:10.000. Mutations of the ryanodine receptor 2, calsequestrin 2 and, less frequently, triadin and calmodulin are found in CPVT patients. We report the case of a four-year old boy with an unreported de novo mutation in the ryanodine receptor 2 (RYR2) confirmed by genetic sequencing. Interestingly, the first cardiac event of our patient was potentially be favoured by inhalative treatment with a short-acting beta-2 agonist.
Maternal Exercise Type and Fetal Echocardiographic Measures
Authors: Linda E. May
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

Background/Aims: While aerobic exercise during pregnancy has been specifically shown to benefit fetal heart dimensions and outflow, the exercise type-specific effects of resistance and combination (resistance and aerobic) exercise have not been explored. The study was performed to independently assess the effects of resistance, aerobic and combination exercise on fetal heart measures in late pregnancy. Materials and Methods: This study utilized 3 exercise intervention groups (aerobic AE n=61, combination AERE n=40, or resistance RE n=33) in comparison to a non-exercise control group (n = 50). At 35-36 weeks of gestation, fetal echocardiographs were obtained via ultrasonography and analyzed for heart rate, cardiac chamber size, and cardiac outflow diameters. Between-group mean differences in fetal measures were assessed by one-way ANOVA for continuous (fetal heart rate, ventricle diameter, stroke volume, cardiac output, vascular diameter) variables. Results: Prenatal exercise altered left ventricular stroke volume and aortic diameter in AE and RE groups, respectively. Maternal exercise dose was significantly (p &lt; .05) and negatively correlated with most measures, including fetal heart rate. Further, fetal heart rate was predicted by maternal fitness level, while fetal right and left ventricular measures were dependent on maternal exercise attendance. Conclusion: These data suggest that different prenatal exercise types are safe for fetal heart development, and that compliance with the recommended prenatal exercise dose contributes to beneficial outcomes.
Ticagrelor Plus Aspirin Therapy in Patients with Stable Coronary Artery Disease, Diabetes, and History of PCI
Authors: Khalid Javed
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

This research study focused specifically on patients with stable coronary artery disease, diabetes, and a history of percutaneous coronary intervention (PCI). The study evaluated the use of Ticagrelor plus aspirin compared to aspirin alone in this population. The combination therapy reduced the risk of MACE compared to aspirin alone but was associated with a higher risk of bleeding. The study showed that Ticagrelor monotherapy, without aspirin, resulted in a lower risk of bleeding events without increasing the risk of MACE compared to dual antiplatelet therapy with Ticagrelor and aspirin.
A Rational Approach to the Diagnosis of Narrow Complex Tachycardia
Authors: Pavel Antiperovitch
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

Supraventricular tachycardias (SVTs) are common arrhythmias in clinical practice – they produce symptoms and lead to frequent emergency department visits1,2. The term “SVT” refers to tachyarrhythmias with a ventricular rate &gt; 100bpm, where the mechanism for the arrythmia involves cardiac tissues above the bundle of His. The majority of SVTs conduct to the ventricles using the His-Purkinje system thereby producing a narrow QRS (&lt; 120bpm). Presence of bundle branch blocks or other methods of aberrancy can result in SVT that presents as a wide QRS tachycardia.
ST-Segment Elevation in a Young Woman with a Brain Bleed
Authors: Belal Sultanzai
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

A 23 yo woman with a history of traumatic brain injury was re-admitted to the hospital two months after initial hospitalization for a traumatic head injury. Readmission was prompted by follow-up computed tomography head scan that revealed hydrocephalus and a shrunken brain for which she underwent cranioplasty and a ventriculoperitoneal shunt. On post-operative day one, she developed “tombstone” ST-segment elevations (STE) which cleared spontaneously without therapeutic intervention. Echocardiography was normal and troponin was minimally elevated. Head CT revealed an epidural hematoma with midline shift, to which the striking ECG changes were attributed. The hematoma was evacuated and the patient was discharged to her care facility. She was readmitted several times during the ensuing eight-months for recurrent hydrocephalus with external ventricular drain placement. During these episodes, there was no evidence of recurrent STE. Although multiple ECG alterations have been described in association with cerebral injury, tombstone STE is rare in this setting.
Pharmacotherapy as an Augmentation to Bariatric Surgery for Obesity
Authors: Luděk Horváth, Miloš Mráz, Edward B. Jude, Martin Haluzík
Journal: Drugs (2024)

Abstract A global obesity pandemic is one of the most significant health threats worldwide owing to its close association with numerous comorbidities such as type 2 diabetes mellitus, arterial hypertension, dyslipidemia, heart failure, cancer and many others. Obesity and its comorbidities lead to a higher rate of cardiovascular complications, heart failure and increased cardiovascular and overall mortality. Bariatric surgery is at present the most potent therapy for obesity, inducing a significant weight loss in the majority of patients. In the long-term, a substantial proportion of patients after bariatric surgery experience a gradual weight regain that may, in some, reach up to a presurgical body weight. As a result, anti-obesity pharmacotherapy may be needed in some patients after bariatric surgery to prevent the weight regain or to further potentiate weight loss. This article provides an overview of the use of anti-obesity medications as an augmentation to bariatric surgery for obesity. Despite relatively limited published data, it can be concluded that anti-obesity medication can serve as an effective adjunct therapy to bariatric surgery to help boost post-bariatric weight loss or prevent weight regain.
Microneedle Patches‐Integrated Transdermal Bioelectronics for Minimally Invasive Disease Theranostics (Adv. Healthcare Mater. 17/2024)
Authors: Zifeng Wang, Min Xiao, Zhanhong Li, Xinghao Wang, Fangjie Li, Huayuan Yang, Yu Chen, Zhigang Zhu
Journal: Advanced Healthcare Materials (2024)
Recent Advances in Nanomedicine for Ocular Fundus Neovascularization Disease Management (Adv. Healthcare Mater. 17/2024)
Authors: Yifan Zhou, Mingyu Xu, Wenyue Shen, Yufeng Xu, An Shao, Peifang Xu, Ke Yao, Haijie Han, Juan Ye
Journal: Advanced Healthcare Materials (2024)
Histatin 5‐Inspired Short‐Chain Peptides Selectively Combating Pathogenic Fungi with Multifaceted Mechanisms (Adv. Healthcare Mater. 17/2024)
Authors: Guojun Lu, Xiaoyan Ju, Meng Zhu, Jinzhao Ou, Dandan Xu, Kejia Li, Wei Jiang, Chenxiao Wan, Ye Tian, Zhongwei Niu
Journal: Advanced Healthcare Materials (2024)
Design of a Novel Delivery Efficiency Feedback System for Biphasic Dissolving Microarray Patches Based on Poly(Lactic Acid) and Moisture‐Indicating Silica (Adv. Healthcare Mater. 17/2024)
Authors: Huanhuan Li, Qonita Kurnia Anjani, Aaron R. J. Hutton, Juan Luis Paris, Natalia Moreno‐Castellanos, Achmad Himawan, Eneko Larrañeta, Ryan F. Donnelly
Journal: Advanced Healthcare Materials (2024)