tbuckley/cabot-search huggingface dataset:
Capacity for the management of kidney failure in the International Society of Nephrology Newly Independent States and Russia region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)
Authors: Larisa Prikhodina, Kirill Komissarov, Nikolay Bulanov, Silvia Arruebo, Aminu K. Bello, Fergus J. Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W. Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G. Okpechi, Marcello Tonelli, Feng Ye, Abduzhappar Gaipov, Atefeh Amouzegar, Aiperi Asanbek Kyzy, Yeoungjee Cho, M. Razeen Davids, Sara N. Davison, Hassane M. Diongole, Smita Divyaveer, Udeme E. Ekrikpo, Isabelle Ethier, Winston Wing-Shing Fung, Anukul Ghimire, Ghenette Houston, Htay Htay, Kwaifa Salihu Ibrahim, Georgina Irish, Dmytro Ivanov, Kailash Jindal, Dearbhla M. Kelly, Komiljon Khamzaev, Rowena Lalji, Aisha M. Nalado, Brendon L. Neuen, Timothy O. Olanrewaju, Mohamed A. Osman, Parnian Riaz, Syed Saad, Aminu Muhammad Sakajiki, Nora Sarishvili, Ashot Sarkissian, Emily See, Olimkhon N. Sharapov, Stephen M. Sozio, Irma Tchokhonelidze, Sophanny Tiv, Somkanya Tungsanga, Andrea Viecelli, Konstantin Vishnevskii, Olga A. Vorobyeva, Marina Wainstein, Emily K. Yeung, Deenaz Zaidi, Elena Zakharova
Journal: Kidney International Supplements (2024)
Capacity for the management of kidney failure in the International Society of Nephrology North America and the Caribbean region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)
Authors: Racquel Lowe-Jones, Isabelle Ethier, Lori-Ann Fisher, Michelle M.Y. Wong, Stephanie Thompson, Georges Nakhoul, Shaifali Sandal, Rahul Chanchlani, Sara N. Davison, Anukul Ghimire, Kailash Jindal, Mohamed A. Osman, Parnian Riaz, Syed Saad, Stephen M. Sozio, Somkanya Tungsanga, Alexandra Cambier, Silvia Arruebo, Aminu K. Bello, Fergus J. Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W. Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G. Okpechi, Marcello Tonelli, Feng Ye, Rulan S. Parekh, Shuchi Anand, Anil K. Agarwal, Atefeh Amouzegar, Carmen Avila-Casado, Everard N. Barton, Suman Behera, Melvin Bonilla Felix, Jorge Cerda, Yeoungjee Cho, Andrey V. Cybulsky, M. Razeen Davids, María Esther Diaz-González de Ferris, Hassane M. Diongole, Smita Divyaveer, Udeme E. Ekrikpo, Agnes B. Fogo, David Friedman, Winston Wing-Shing Fung, Susan L. Furth, John Gill, Ghenette Houston, Li-Li Hsiao, Chi-yuan Hsu, Htay Htay, Kwaifa Salihu Ibrahim, Georgina Irish, Sabine Karam, Dearbhla M. Kelly, Rowena Lalji, Edgar V. Lerma, Fabrice Mac-Way, Etienne Macedo, Hassina Mohammed, Devika Nair, Aisha M. Nalado, Brendon L. Neuen, Timothy O. Olanrewaju, Xavier Fernanco Vela Parada, Roberto Pecoits-Filho, Anna Petrova, Bhanu Prasad, Lisa Radix, Rupesh Raina, Avinash Rao Ullur, Mitchell H. Rosner, Aminu Muhammad Sakajiki, Emily See, Surya V. Seshan, Isaac Teitelbaum, Ian Thomas, Sophanny Tiv, Michele Trask, Tushar J. Vachharajani, Andrea Viecelli, Marina Wainstein, Michael Walsh, Christina Wyatt, Karen Yeates, Emily K. Yeung, Sandrica Young-Peart, Deenaz Zaidi
Journal: Kidney International Supplements (2024)
Distinct patterns of vital sign and inflammatory marker responses in adults with suspected bloodstream infection
Authors: Qingze Gu, Jia Wei, Chang Ho Yoon, Kevin Yuan, Nicola Jones, Andrew Brent, Martin Llewelyn, Tim E.A. Peto, Koen B. Pouwels, David W. Eyre, A.Sarah Walker
Journal: Journal of Infection (2024)

To identify patterns in inflammatory marker and vital sign responses in adult with suspected bloodstream infection (BSI) and define expected trends in normal recovery.
Capacity for the management of kidney failure in the International Society of Nephrology South Asia region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)
Authors: Eranga Wijewickrama, Muhammad Rafiqul Alam, Divya Bajpai, Smita Divyaveer, Arpana Iyengar, Vivek Kumar, Ahad Qayyum, Shankar Prasad Yadav, Manjusha Yadla, Silvia Arruebo, Aminu K. Bello, Fergus J. Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W. Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G. Okpechi, Marcello Tonelli, Feng Ye, Dibya Singh Shah, Narayan Prasad, Anil K. Agarwal, Ejaz Ahmed, Suceena Alexander, Atefeh Amouzegar, Urmila Anandh, Shyam Bihari Bansal, Pramod Kumar Chhetri, Yeoungjee Cho, Ugyen Choden, Nizamuddin Chowdury, Arvind Conjeevaram, M. Razeen Davids, Sara N. Davison, Hassane M. Diongole, Udeme E. Ekrikpo, Isabelle Ethier, Edwin Fernando Mervin, Winston Wing-Shing Fung, Reena Rachel George, Anukul Ghimire, Basu Gopal, Swarnalatha Guditi, Chula Herath, Ghenette Houston, Htay Htay, Kwaifa Salihu Ibrahim, Georgina Irish, Kailash Jindal, Ahmad Baseer Kaihan, Shubharthi Kar, Tasnuva Kashem, Dearbhla M. Kelly, Asia Khanam, Vijay Kher, Rowena Lalji, Sandeep Mahajan, Aisha M. Nalado, Rubina Naqvi, K.S. Nayak, Brendon L. Neuen, Timothy O. Olanrewaju, Mohamed A. Osman, Sreejith Parameswaran, Klara Paudel, Anna Petrova, Harun Ur Rashid, Parnian Riaz, Syed Saad, Manisha Sahay, Aminu Muhammad Sakajiki, Emily See, Mythri Shankar, Ajay P. Sharma, Sourabh Sharma, Ibrahim Shiham, Geetika Singh, Stephen M. Sozio, Sophanny Tiv, Mayuri Trivedi, Somkanya Tungsanga, Andrea Viecelli, Marina Wainstein, Abdul Wazil, Dilushi Wijayaratne, Emily K. Yeung, Deenaz Zaidi
Journal: Kidney International Supplements (2024)
Capacity for the management of kidney failure in the International Society of Nephrology Western Europe region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)
Authors: Maria Pippias, Gaetano Alfano, Dearbhla M. Kelly, Maria Jose Soler, Letizia De Chiara, Timothy O. Olanrewaju, Silvia Arruebo, Aminu K. Bello, Fergus J. Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W. Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G. Okpechi, Marcello Tonelli, Feng Ye, Rosanna Coppo, Liz Lightstone, Atefeh Amouzegar, Hans-Joachim Anders, Jyoti Baharani, Debasish Banerjee, Boris Bikbov, Edwina A. Brown, Yeoungjee Cho, Kathleen Claes, Naomi Clyne, M. Razeen Davids, Sara N. Davison, Hassane M. Diongole, Smita Divyaveer, Gavin Dreyer, Jan Dudley, Udeme E. Ekrikpo, Isabelle Ethier, Rhys D.R. Evans, Stanley L.S. Fan, Winston Wing-Shing Fung, Maurizio Gallieni, Anukul Ghimire, Ghenette Houston, Htay Htay, Kwaifa Salihu Ibrahim, Georgina Irish, Kailash Jindal, Arif Khwaja, Rowena Lalji, Vassilios Liakopoulos, Valerie A. Luyckx, Manuel Macia, Hans Peter Marti, Piergiorgio Messa, Thomas F. Müller, Aisha M. Nalado, Brendon L. Neuen, Dorothea Nitsch, Fernando Nolasco, Rainer Oberbauer, Mohamed A. Osman, Aikaterini Papagianni, Anna Petrova, Giorgina Barbara Piccoli, Liam Plant, Giuseppe Remuzzi, Parnian Riaz, Joris J. Roelofs, Michael Rudnicki, Syed Saad, Aminu Muhammad Sakajiki, Johannes B. Scheppach, Emily See, Rukshana Shroff, Marit D. Solbu, Stephen M. Sozio, Giovanni FM. Strippoli, Maarten W. Taal, James Tataw Ashu, Sophanny Tiv, Somkanya Tungsanga, Jeroen B. van der Net, Raymond C. Vanholder, Andrea Viecelli, Katie Vinen, Bruno Vogt, Marina Wainstein, Talia Weinstein, David C. Wheeler, Emily K. Yeung, Deenaz Zaidi
Journal: Kidney International Supplements (2024)
Capacity for the management of kidney failure in the International Society of Nephrology Africa region: report from the 2023 ISN Global Kidney Atlas (ISN-GKHA)
Authors: Elliot Koranteng Tannor, Bianca Davidson, Yannick Nlandu, Peace Bagasha, Workagegnehu Hailu Bilchut, M. Razeen Davids, Hassane M. Diongole, Udeme E. Ekrikpo, Ehab O.A. Hafiz, Kwaifa Salihu Ibrahim, Robert Kalyesubula, Aisha M. Nalado, Timothy O. Olanrewaju, Ugochi Chika Onu, Nikhil Pereira-Kamath, Aminu Muhammad Sakajiki, Mohamed Salah, Lloyd Vincent, Silvia Arruebo, Aminu K. Bello, Fergus J. Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W. Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G. Okpechi, Marcello Tonelli, Feng Ye, Gloria Enow Ashuntantang, Fatiu Abiola Arogundade, Mohammed Abdel Gawad, Ezzedine Abderrahim, Ahmed Akl, Eyram Makafui Yoan Amekoudi, Atefeh Amouzegar, Jacob Olugbenga Awobusuyi, Omran Bakoush, Elsa R. Chissico, Yeoungjee Cho, Joshua Coker, Brett Cullis, Rumbidzai Dahwa, Rasha Ahmed Darwish, Sara N. Davison, Smita Divyaveer, Isabelle Ethier, Kevin Fagoonee, Aboubacar Sidiki Fofana, Robert Freercks, Winston Wing-Shing Fung, Pierre Eric Gandzali-Ngabe, Anukul Ghimire, Zaghloul Elsafy Gouda, Oswald Habyarimana, Htay Htay, Davy Ip Min Wan, Georgina Irish, Wesam Ismail, Abubacarr Jagne, Faiçal Jarraya, Kailash Jindal, Babikir G. Kabllo, Ahmed Y. Kalebi, François F. Kaze Folefack, Dearbhla M. Kelly, Rowena Lalji, Ben Lomatayo, Sidi Mohamed Mah, Guillaume Zalba Mahamat Abderraman, Mignon McCulloch, Yewondwossen Tadesse Mengistu, Mothusi Walter Moloi, Chisambo Mwaba, Brendon L. Neuen, John Ngigi, Abdou Niang, Joseph Nyandwi, Emad Odeh, Mohamed A. Osman, Cédric Patrick Le Grand Ouanekpone, Anna Petrova, Eliane M. Ranivoharisoa, Parnian Riaz, Syed Saad, Emily See, Ahmed Sokwala, Adaobi Uzoamaka Solarin, Stephen M. Sozio, Tarik Sqalli Houssani, Ernest Sumaili Kiswaya, Weu Melanie Tia, Sophanny Tiv, Thabang Ts'enoli, Somkanya Tungsanga, Ifeoma I. Ulasi, Ssentamu John Vanglist, Andrea Viecelli, Shoyab Wadee, Marina Wainstein, Nicola Wearne, Emily K. Yeung, Deenaz Zaidi
Journal: Kidney International Supplements (2024)
A systematic review and multivariate meta-analysis of the physical and mental health benefits of touch interventions
Authors: Julian Packheiser, Helena Hartmann, Kelly Fredriksen, Valeria Gazzola, Christian Keysers, Frédéric Michon
Journal: Nature Human Behaviour (2024)

Receiving touch is of critical importance, as many studies have shown that touch promotes mental and physical well-being. We conducted a pre-registered (PROSPERO: CRD42022304281) systematic review and multilevel meta-analysis encompassing 137 studies in the meta-analysis and 75 additional studies in the systematic review (n = 12,966 individuals, search via Google Scholar, PubMed and Web of Science until 1 October 2022) to identify critical factors moderating touch intervention efficacy. Included studies always featured a touch versus no touch control intervention with diverse health outcomes as dependent variables. Risk of bias was assessed via small study, randomization, sequencing, performance and attrition bias. Touch interventions were especially effective in regulating cortisol levels (Hedges' g = 0.78, 95% confidence interval (CI) 0.24 to 1.31) and increasing weight (0.65, 95% CI 0.37 to 0.94) in newborns as well as in reducing pain (0.69, 95% CI 0.48 to 0.89), feelings of depression (0.59, 95% CI 0.40 to 0.78) and state (0.64, 95% CI 0.44 to 0.84) or trait anxiety (0.59, 95% CI 0.40 to 0.77) for adults. Comparing touch interventions involving objects or robots resulted in similar physical (0.56, 95% CI 0.24 to 0.88 versus 0.51, 95% CI 0.38 to 0.64) but lower mental health benefits (0.34, 95% CI 0.19 to 0.49 versus 0.58, 95% CI 0.43 to 0.73). Adult clinical cohorts profited more strongly in mental health domains compared with healthy individuals (0.63, 95% CI 0.46 to 0.80 versus 0.37, 95% CI 0.20 to 0.55). We found no difference in health benefits in adults when comparing touch applied by a familiar person or a health care professional (0.51, 95% CI 0.29 to 0.73 versus 0.50, 95% CI 0.38 to 0.61), but parental touch was more beneficial in newborns (0.69, 95% CI 0.50 to 0.88 versus 0.39, 95% CI 0.18 to 0.61). Small but significant small study bias and the impossibility to blind experimental conditions need to be considered. Leveraging factors that influence touch intervention efficacy will help maximize the benefits of future interventions and focus research in this field.
Impact of high-performance human papillomavirus testing to improve cervical cancer screening in China: a prospective population-based multicentre cohort study
Authors: Jian Yin, Shaokai Zhang, Zhifang Li, Yufei Li, Hong Wang, Xun Zhang, Qinjing Pan, Wen Chen, Xiping Luo, Xibin Sun, Fanghui Zhao, Youlin Qiao
Journal: Clinical Microbiology and Infection (2024)
Capacity for the management of kidney failure in the International Society of Nephrology Middle East region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)
Authors: Sabine Karam, Atefeh Amouzegar, Iman Rashed Alshamsi, Saeed M.G. Al Ghamdi, Siddiq Anwar, Mohammad Ghnaimat, Bassam Saeed, Silvia Arruebo, Aminu K. Bello, Fergus J. Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W. Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G. Okpechi, Marcello Tonelli, Feng Ye, Ali K. Abu-Alfa, Shokoufeh Savaj, Pauline Abou-Jaoudeh, Turki Al Hussain, Issa Salim Amur Al Salmi, Mona Alrukhaimi, Anas Alyousef, Sola Aoun Bahous, Guangyan Cai, Hicham I. Cheikh Hassan, Yeoungjee Cho, M. Razeen Davids, Sara N. Davison, Hassane M. Diongole, Smita Divyaveer, Udeme E. Ekrikpo, Isabelle Ethier, Winston Wing-Shing Fung, Anukul Ghimire, Nakysa Hooman, Ghenette Houston, Htay Htay, Kwaifa Salihu Ibrahim, Georgina Irish, Kailash Jindal, Dearbhla M. Kelly, Rowena Lalji, Ahmed Mitwali, Mojgan Mortazavi, Aisha M. Nalado, Brendon L. Neuen, Timothy O. Olanrewaju, Mohamed A. Osman, Shahrzad Ossareh, Anna Petrova, Parnian Riaz, Syed Saad, Aminu Muhammad Sakajiki, Emily See, Stephen M. Sozio, Sophanny Tiv, Somkanya Tungsanga, Andrea Viecelli, Marina Wainstein, Hala Wannous, Emily K. Yeung, Deenaz Zaidi
Journal: Kidney International Supplements (2024)
Capacity for the management of kidney failure in the International Society of Nephrology Latin America region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)
Authors: Viviane Calice-Silva, Javier A. Neyra, Alejandro Ferreiro Fuentes, Krissia Kamile Singer Wallbach Massai, Silvia Arruebo, Aminu K. Bello, Fergus J. Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W. Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G. Okpechi, Marcello Tonelli, Feng Ye, Magdalena Madero, Carmen Tzanno Martins, Guillermo Alvarez, Atefeh Amouzegar, Denisse Arellano-Mendez, Gustavo Aroca Martinez, Roger Ayala Ferrari, Carlos Bonano, Edwin Castillo Velarde, Jonathan Samuel Chavez Iñiguez, Yeoungjee Cho, Rolando Claure-Del Granado, Ricardo Correa-Rotter, Alfonso M. Cueto Manzano, Ana Maria Cusumano, M. Razeen Davids, Sara N. Davison, Hassane M. Diongole, Smita Divyaveer, Udeme E. Ekrikpo, Isabelle Ethier, Ana Elizabeth Figueiredo, Winston Wing-Shing Fung, Guillermo Garcia Garcia, Anukul Ghimire, Martin Gomez, Maria Carlota Gonzalez Bedat, Ghenette Houston, Htay Htay, Kwaifa Salihu Ibrahim, Georgina Irish, Kailash Jindal, Dearbhla M. Kelly, Rowena Lalji, José A. Moura-Neto, Aisha M. Nalado, Brendon L. Neuen, Oscar Noboa, Irene L. Noronha, Timothy O. Olanrewaju, Mohamed A. Osman, Ana Cecilia Pastor Ludena, Anna Petrova, Andrea Pio-Abreu, Parnian Riaz, Jorge Rico-Fontalvo, Guillermo Rosa-Diez, Syed Saad, Aminu Muhammad Sakajiki, Angel Cristóbal Santacruz, Juan Santacruz, Emily See, Augusto Cesar Soares dos Santos Junior, Laura Sola, Stephen M. Sozio, Sophanny Tiv, Hernan Trimarchi, Somkanya Tungsanga, Andrea Viecelli, Marina Wainstein, Emily K. Yeung, Deenaz Zaidi
Journal: Kidney International Supplements (2024)
The PAP-RES algorithm: Defining who, why and how to use positive airway pressure therapy for OSA
Authors: Frédéric Gagnadoux, Emilie Bequignon, Arnaud Prigent, Jean-Arthur Micoulaud-Franchi, Juliette Chambe, Joëlle Texereau, Sarah Alami, Frédéric Roche
Journal: Sleep Medicine Reviews (2024)

Obstructive sleep apnea (OSA) is a common condition that is increasing in prevalence worldwide. Untreated OSA has a negative impact on health-related quality of life and is an independent risk factor for cardiovascular diseases. Despite available data suggesting that cardiovascular risk might differ according to clinical phenotypes and comorbidities, current approaches to OSA treatment usually take a "one size fits all" approach. Identification of cardiovascular vulnerability biomarkers and clinical phenotypes associated with response to positive airway pressure (PAP) therapy could help to redefine the standard treatment paradigm. The new PAP-RES (PAP-RESponsive) algorithm is based on the identification of OSA phenotypes that are likely to impact therapeutic goals and modalities. The paradigm shift is to propose a simplified approach that defines therapeutic goals based on OSA phenotype: from a predominantly "symptomatic phenotype" (individuals with high symptom burden that negatively impacts on daily life and/or accident risk or clinically significant insomnia) to a "vulnerable cardiovascular phenotype" (individuals with comorbidities [serious cardiovascular or respiratory disease or obesity] that have a negative impact on cardiovascular prognosis or a biomarker of hypoxic burden and/or autonomic nervous system dysfunction). Each phenotype requires a different PAP therapy care pathway based on differing health issues and treatment objectives.
Capacity for the management of kidney failure in the International Society of Nephrology Oceania and South East Asia (OSEA) region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)
Authors: Anna Francis, Marina Wainstein, Georgina Irish, Muhammad Iqbal Abdul Hafidz, Titi Chen, Yeoungjee Cho, Htay Htay, Talerngsak Kanjanabuch, Rowena Lalji, Brendon L. Neuen, Emily See, Anim Shah, Brendan Smyth, Somkanya Tungsanga, Andrea Viecelli, Emily K. Yeung, Silvia Arruebo, Aminu K. Bello, Fergus J. Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W. Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G. Okpechi, Marcello Tonelli, Feng Ye, Muh Geot Wong, Sunita Bavanandan, Abdul Halim Abdul Gafor, Atefeh Amouzegar, Paul Bennett, Sonia L. Chicano, M. Razeen Davids, Sara N. Davison, Hassane M. Diongole, Smita Divyaveer, Udeme E. Ekrikpo, Isabelle Ethier, Voon Ken Fong, Winston Wing-Shing Fung, Anukul Ghimire, Basu Gopal, Hai An Ha Phan, David C.H. Harris, Ghenette Houston, Kwaifa Salihu Ibrahim, Meg J. Jardine, Kailash Jindal, Surasak Kantachuvesiri, Dearbhla M. Kelly, Peter Kerr, Siah Kim, Rathika Krishnasamy, Jia Liang Kwek, Vincent Lee, Adrian Liew, Chiao Yuen Lim, Aida Lydia, Aisha M. Nalado, Timothy O. Olanrewaju, Mohamed A. Osman, Anna Petrova, Khin Phyu Pyar, Parnian Riaz, Syed Saad, Aminu Muhammad Sakajiki, Noot Sengthavisouk, Stephen M. Sozio, Nattachai Srisawat, Eddie Tan, Sophanny Tiv, Isabelle Dominique Tomacruz Amante, Anthony Russell Villanueva, Rachael Walker, Robert Walker, Deenaz Zaidi
Journal: Kidney International Supplements (2024)
Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB
Authors: Kegang Linghu, Wenqing Cui, Taiqin Li, Yueting Tuo, Dasong Wang, Huiqi Pan, Tian Zhang, Ligen Lin, Hua Yu, Xiaoxia Hu, Haiyang Li, Xiangchun Shen
Journal: Acta Pharmaceutica Sinica B (2024)

Rheumatoid arthritis (RA) is an inflammatory disease accompanied by abnormal synovial microenvironment (SM). Sesquiterpene lactones (SLs) are the main anti-inflammatory ingredients of many traditional herbs utilized in RA treatment.
Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndromes (IVUS-ACS): a two-stage, multicentre, randomised trial
Authors: Xiaobo Li, Zhen Ge, Jing Kan, Muhammed Anjum, Ping Xie, Xiang Chen, Hamid Sharif Khan, Xiaomei Guo, Tahir Saghir, Jing Chen, Badar Ul Ahad Gill, Ning Guo, Imad Sheiban, Afsar Raza, Yongyue Wei, Feng Chen, Gary S Mintz, Jun-Jie Zhang, Gregg W Stone, Shao-Liang Chen, Xiaobo Li, Zhen Ge, Jing Kan, Muhammed Anjum, Fei Ye, Xiaofei Gao, Anjum Jalal, Ping Xie, Ling Tao, Xiang Chen, Hamid S Khan, Asim Javed, Yibin Shao, Xiaomei Guo, Feng Li, Tahir Saghir, Naeem Mengal, Shaoping Nie, Hong Qu, Xuesong Qian, Song Yang, Jing Chen, Dasheng Gao, Lijun Liu, Mingliang Wang, Lianglong Chen, Fan Liu, Tan Xu, Yinwu Liu, Badar Ul Ahad Gill, Qing Yang, Nin Guo, Shangyu Wen, Hongliang Cong, Lang Hong, Imad Sheiban, Afsar Raza, Yongyue Wei, Feng Chen, Gary S Mintz, Jun-Jie Zhang, Gregg W Stone, Shao-Liang Chen
Journal: The Lancet (2024)
Type III interferon inhibits bladder cancer progression by reprogramming macrophage-mediated phagocytosis and orchestrating effective immune responses
Authors: Bo Wang, Bingkun Zhou, Junyu Chen, Xi Sun, Wenjuan Yang, Tenghao Yang, Hao Yu, Peng Chen, Ke Chen, Xiaodong Huang, Xinxiang Fan, Wang He, Jian Huang, Tianxin Lin
Journal: Journal for ImmunoTherapy of Cancer (2024)

Background Interferons (IFNs) are essential for activating an effective immune response and play a central role in immunotherapy-mediated immune cell reactivation for tumor regression. Type III IFN (λ), related to type I IFN (α), plays a crucial role in infections, autoimmunity, and cancer. However, the direct effects of IFN-λ on the tumor immune microenvironment have not been thoroughly investigated. Methods We used mouse MB49 bladder tumor models, constructed a retroviral vector expressing mouse IFN-λ3, and transduced tumor cells to evaluate the antitumor action of IFN-λ3 in immune-proficient tumors and T cell-deficient tumors. Furthermore, human bladder cancer samples (cohort 1, n=15) were used for immunohistochemistry and multiplex immunoflurescence analysis to assess the expression pattern of IFN-λ3 in human bladder cancer and correlate it with immune cells’ infiltration. Immunohistochemistry analysis was performed in neoadjuvant immunotherapy cohort (cohort 2, n=20) to assess the correlation between IFN-λ3 expression and the pathological complete response rate. Results In immune-proficient tumors, ectopic Ifnl3 expression in tumor cells significantly increased the infiltration of cytotoxic CD8 + T cells, Th1 cells, natural killer cells, proinflammatory macrophages, and dendritic cells, but reduced neutrophil infiltration. Transcriptomic analyses revealed significant upregulation of many genes associated with effective immune response, including lymphocyte recruitment, activation, and phagocytosis, consistent with increased antitumor immune infiltrates and tumor inhibition. Furthermore, IFN-λ3 activity sensitized immune-proficient tumors to anti-PD-1/PD-L1 blockade. In T cell-deficient tumors, increased Ly6G – Ly6C + I-A/I-E + macrophages still enhanced tumor cell phagocytosis in Ifnl3 overexpressing tumors. IFN-λ3 is expressed by tumor and stromal cells in human bladder cancer, and high IFN-λ3 expression was positively associated with effector immune infiltrates and the efficacy of immune checkpoint blockade therapy. Conclusions Our study indicated that IFN-λ3 enables macrophage-mediated phagocytosis and antitumor immune responses and suggests a rationale for using Type III IFN as a predictive biomarker and potential immunotherapeutic candidate for bladder cancer.