tbuckley/cabot-search huggingface dataset:
Abstract 1320: A Novel Nanotechnology-Based Strategy for Therapeutic Neovascularization: Local Delivery of Statin with Biodegradable Polymeric Nanoparticle Improves Therapeutic Efficacy of Ischemic Neovascularization
Authors: Mitsuki Kubo, Kensuke Egashira, Takahiro Inoue, Yoshiaki Kawashima, Hiroyuki Tsujimoto, Kaori Hara, Kenji Sunagawa
Journal: Circulation (2006)
Assaults on psychiatrists by patients
Authors: Denis J. Madden, John R. Lion, Manoel W. Penna
Journal: American Journal of Psychiatry (1976)

The authors describe the results of a survey of 115 psychiatrists regarding assaults by patients. Forty-eight psychiatrists stated that they had been assaulted; a total of 68 assaults was reported. Psychiatrists were most often assaulted in the early stages of their career or while they were working in high-risk settings such as prisons or emergency rooms. Many reported retrospectively that they might have had a role in provoking the assault and that they could have anticipated it. The authors believe that psychiatrists avoid dealing with the issue of violence by patients for a variety of reasons, and they recommend that clinicians learn techniques for managing potentially assaultive patients.
WHO partogram helps
Authors: C. Lennox
Journal: BMJ (1994)

EDITOR, - James G Thornton and Richard J Lilford's review of active management of labour1 was accepted for publication too late for it to include the results of the multicentre trial of the World Health Organisation partogram.2 Although not a randomised controlled trial (it would be impossible to conduct such a trial free from bias), this trial of the impact of use of the partogram with an agreed protocol for managing labour on the outcome of labour is important because of its scientific rigour, the fact that it was a multicentre study, and, in particular, the large …
Deviation from intention to treat analysis in randomised trials and treatment effect estimates: meta-epidemiological study
Authors: I. Abraha, A. Cherubini, F. Cozzolino, R. De Florio, M. L. Luchetta, J. M. Rimland, I. Folletti, M. Marchesi, A. Germani, M. Orso, P. Eusebi, A. Montedori
Journal: BMJ (2015)

<b>Objective </b>To examine whether deviation from the standard intention to treat analysis has an influence on treatment effect estimates of randomised trials. <b>Design</b> Meta-epidemiological study. <b>Data sources</b> Medline, via PubMed, searched between 2006 and 2010; 43 systematic reviews of interventions and 310 randomised trials were included. <b>Eligibility criteria for selecting studies</b> From each year searched, random selection of 5% of intervention reviews with a meta-analysis that included at least one trial that deviated from the standard intention to treat approach. Basic characteristics of the systematic reviews and randomised trials were extracted. Information on the reporting of intention to treat analysis, outcome data, risk of bias items, post-randomisation exclusions, and funding were extracted from each trial. Trials were classified as: ITT (reporting the standard intention to treat approach), mITT (reporting a deviation from the standard approach), and no ITT (reporting no approach). Within each meta-analysis, treatment effects were compared between mITT and ITT trials, and between mITT and no ITT trials. The ratio of odds ratios was calculated (value &lt;1 indicated larger treatment effects in mITT trials than in other trial categories)<i>.</i> <b>Results</b> 50 meta-analyses and 322 comparisons of randomised trials (from 84 ITT trials, 118 mITT trials, and 108 no ITT trials; 12 trials contributed twice to the analysis) were examined. Compared with ITT trials, mITT trials showed a larger intervention effect (pooled ratio of odds ratios 0.83 (95% confidence interval 0.71 to 0.96), P=0.01; between meta-analyses variance τ<sup>2</sup>=0.13). Adjustments for sample size, type of centre, funding, items of risk of bias, post-randomisation exclusions, and variance of log odds ratio yielded consistent results (0.80 (0.69 to 0.94), P=0.005; τ<sup>2</sup>=0.08). After exclusion of five influential studies, results remained consistent (0.85 (0.75 to 0.98); τ<sup>2</sup>=0.08). The comparison between mITT trials and no ITT trials showed no statistical difference between the two groups (adjusted ratio of odds ratios 0.92 (0.70 to 1.23); τ<sup>2</sup>=0.57). <b>Conclusions</b> Trials that deviated from the intention to treat analysis showed larger intervention effects than trials that reported the standard approach. Where an intention to treat analysis is impossible to perform, authors should clearly report who is included in the analysis and attempt to perform multiple imputations.
Nursing Mental and Nervous Diseases from the View-Points of Biology, Psychology and Neurology. A Text-Book for Use in Schools for the Training of Nurses.
Authors: Albert Coulson Buckley
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Promotion in Urinary Bladder Carcinogenesis
Authors: Samuel M. Cohen
Journal: Environmental Health Perspectives (1983)

Aromatic amines, including 2-naphthylamine, 4-aminobiphenyl and benzidine, are known urinary bladder carcinogens in man and other species, but in rodents, aromatic amines and amides have usually induced liver tumors, occasionally also with tumors of the bladder and other tissues. Variations in organ specificity are related to differences in metabolism; for the production of bladder tumors, the rates of acetylation and deacetylation appear to be critical. Bladder specific carcinogens in rodents and other species have subsequently been identified, including N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) administered in the drinking water, N-[(4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) in the diet and N-methyl-N-nitrosourea (MNU) instilled intravesically. When low doses of several bladder carcinogens (BBN, FANFT, 2-acetylaminofluorene, and 3,3'-dichlorobenzidine) are administered to rats, either simultaneously or sequentially, a synergistic effect is observed with respect to bladder carcinogenesis. In addition, a multistage carcinogenesis process has been demonstrated for the rat bladder using MNU or FANFT as initiators, and dietary sodium saccharin, sodium cyclamate, or tryptophan as promoters. Calculi (or pellets) appear to enhance the promotion process but are not necessary for it to occur. Recent studies also indicate that urine has a role in the promoting process. The urothelium normally has a very low mitotic rate. If mucosal proliferation is increased, such as during fetal development or during regeneration and repair of an ulcer, the bladder appears to be considerably more sensitive to the effects of promoting substances. For example, if sodium saccharin is administered to rats after ulceration of the bladder, even without prior administration of an initiator, bladder carcinoma develops. Under these conditions, the substance appears as a carcinogen. Human populations with increased bladder epithelial proliferation, such as fetus, infants, patients with bacterial cystitis or men with partially obstructive prostatism, may have increased susceptibility to the action of carcinogenic or promoting stimuli.
Abstract 417: Normalized Wall Index Predicts New Fibrous Cap Rupture and New Intraplaque Hemorrhage in the Carotid Atherosclerotic Lesion
Authors: Hunter R Underhill, Chun Yuan, Vasily L Yarnykh, Baocheng Chu, Minako Oikawa, Nayak L Polissar, Stephen M Schwartz, Gail P Jarvik, Thomas S Hatsukami
Journal: Circulation (2008)

Purpose: We sought to determine the prevalence, incidence and predictors of fibrous cap (FC) rupture and intraplaque hemorrhage (IPH) in the carotid artery. Methods: 108 asymptomatic individuals (m...
Dreads and Besetting Fears, Including States of Anxiety, Their Causes and Cure.
Authors: Tom A. Williams
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Children in Play Therapy: A Key to Understanding Normal and Disturbed Emotions
Authors: Clark E. Moustakas
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12170: Increasing HDL Functionality Improved the Survival Rate after Myocardial Infarction
Authors: Eiji Yahiro, Yoshinari Uehara, Shin-ichiro Miura, Keijiro Saku
Journal: Circulation (2012)

Background:  Recently, a high dose of reconstituted (rHDL), apolipoprotein (Apo) A-I Milano, has been shown to significantly reduce the volume of atherosclerotic plaque. Since rHDL is not yet available for clinical use, we newly developed Fukuoka ApoA-I mimetic peptide (FAMP) with 24 amino acids without a phospholipid, which binds to ABCA1 transporter. We examined whether the direct injection of FAMP affected the condition of acute myocardial infarction (MI) in mice.   Method and Results:  Eight- to 10-week-old C57Bl/6J male mice were subjected to left anterior coronary artery ligation for 1 week as a model of MI. Control mice were injected intraperitoneally (i.p.) with PBS. FAMP was injected i.p. at 10mg/kg (FAMP-L) or 50mg/kg (FAMP-H). All 3 groups showed a similar degree of LV infarct size. However, the survival rate during the acute phase after MI improved particularly well in the FAMP-H group (8/9, 89%), compared to the FAMP-L (8/11, 73%) and control (7/13, 54%) groups. We then evaluated mRNA expression (eNOS, MCP-1, Gata 4 and p53, etc.) in the heart. The FAMP-L and FAMP-H groups showed significant reductions in MCP-1 mRNA levels. In addition, mRNA levels of some angiogenic compounds (eNOS, Gata 4) were significantly up-regulated by FAMP-L, and a trend was seen in the FAMP-H group. Furthermore, we explored mRNA levels in the heart in the very acute phase of MI. Similarly, the expression levels of anti-inflammatory were suppressed and angiogenic compounds were up-regulated in this acute phase. These results suggested that FAMP might improve the survival rate in the acute phase after MI through HDL-functionality, such as anti-inflammatory and vasculoangiogenic effects in the heart. In addition, capillary isotachoelectrophoresis showed that FAMP attacked circulating HDL, modified the configuration of HDL, and made massive pre-beta HDL, thus improving HDL functionality.   Conclusion:  Our newly developed Apo A-I mimetic peptide, FAMP, had beneficial effects in a mouse model of MI. FAMP increased the mRNA levels of some angiogenic compounds and also suppressed the mRNA of inflammatory cytokines, probably through the production of pre-beta HDL. Thus, FAMP may be useful in a new strategy for the prevention of sudden cardiac death after MI.
Abstract 109: Lower Ventilation Rates Improve Brain Tissue Oxygenation and Perfusion During Hemorrhagic Shock
Authors: Ahamed H Idris, Samuel Luber, Joseph P Minei, Christopher Madden, Ronnie J Brown, Paul P Pepe
Journal: Circulation (2006)

Background: Recent studies showed that arterial blood pressure during hemorrhagic shock is made worse with hyperventilation and improved with a ventilation rate of 6 breaths/min. Objective: To comp...
Number needed to treat
Authors: D. North
Journal: BMJ (1995)

by 25% to 33% overall.Of more importance is that the proportion of children with extended illness- that is, those who do not experience signs of improvement until after the fourth day of illness- was reduced from 20% to 3% in placebo controlled clinical trials.`"In other words, those who need it most benefit most.What price tag can we attach to that?D J Paynton's family probably did not experience the usual situation of secondary cases in the family being more severe than the index case.My family was less fortunate.One winter before oral acyclovir was available my three children had chickenpox one after the other in painfully slow succession.My son, the tertiary case, was nearly admitted to hospital because of central nervous system complications that were, in retrospect, due to a concomitant infection with influenza A virus.The service implication of an additional treat- ment option is a valid concern.My suggestion would be to set up a triage system so that only questionable cases need be seen by a practitioner.In my experience, the parents or guardians are reliable at recognising chickenpox, epecially after they have suffered through the index case.
Mitral Valve Area During Exercise After Restrictive Mitral Valve Annuloplasty
Authors: Philippe B. Bertrand, Frederik H. Verbrugge, David Verhaert, Christophe J.P. Smeets, Lars Grieten, Wilfried Mullens, Herbert Gutermann, Robert A. Dion, Robert A. Levine, Pieter M. Vandervoort
Journal: Journal of the American College of Cardiology (2015)
Efficacy and feasibility of intensive induction therapy in very elderly patients with acute myeloid leukaemia
Authors: G. Biaggi, A. Santagostino, D. Manachino, T. Posca, G. Forti, S. Salva, E. De Marino
Journal: Journal of Clinical Oncology (2006)

16528 Background: Intensive Induction Treatment (IIT) increases chances of longer survival in acute myeloid leukaemia (AML). Our aim was to improve outcome and to evaluate safety and tolerability of IIT in very elderly patients (pts). Otherwise they have a median surviving time of 11 weeks without treatment. Methods: From October 2003 to November 2005 we treated 23 pts, 16 Males (M) and 7 Female (F); median age 75.5 years (range 68–95). According FAB classification they were 1 M0, 10 M1, 5 M2, 6 M4, 1 M5. ECOG performance status (PS) was 0 in 6 pts, 1 in 5 pts, 2 in 7 pts and 3 in 5 pts. All pts underwent IIT with different schedules: only a female 95 years old had less intensive treatment. Immune-chemotherapy was also admitted. Schedules were: 3+7 IDA+ARA-C in 8 pts; MY-FLAI in 7 pts; VP+ARA-C 1 = ≥ 5 in 2 pts; IDA+ARA-C 1 = ≥ 2 in 4 pts; ARA-C + 6TG in 1 pt. Eleven pts underwent second line treatment. Results: Five pts are alive and 18 dead. We obtained 7 complete responses (CR) (32%) and 1 partial response (PR) (RR 36%);. The median CR duration was 7.5 months (range 1–12).Throughout IIT we observed 5 toxic deaths (23%) because of infections and 2 deaths not leukaemia therapy related (heart failure). The median Overall Survival (OS) was 9 months. Conclusions: Despite the toxic deaths due to the treatment, we obtained in 32% of the pts CR longer compared to palliative or best supportive care; also the median OS was longer than we can expected without chemotherapy. Our data support in our opinion the feasibility and the utility of an IIT in very elderly patients with good PS. No significant financial relationships to disclose.
Response of borderline and schizotypal patients to small doses of thiothixene and haloperidol
Authors: G Serban, S Siegel
Journal: American Journal of Psychiatry (1984)

The improvement in the clinical methods of identifying borderline subjects makes it necessary to reevaluate the efficacy of the treatment offered them. A random sample of 52 borderline and schizotypal patients was treated with two major neuroleptics, thiothixene and haloperidol, in a double-blind study. Eighty-four percent were markedly to moderately improved at 3-month follow-up; the patients responded better to thiothixene than to haloperidol. The main areas of positive response were those of cognitive disturbance, derealization, ideas of reference, anxiety, and depression. The patients also showed improvement in self-image and social functioning. There was no significant relationship between diagnosis and outcome of treatment.
Obstetrics in General Practice
Authors: D.B. Brown
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of 2006 ASCO Annual Meeting data release of Cancer and Leukemia Group B (CALGB) protocol 9633 on practice patterns in the United States
Authors: J. L. Close, L. Daniels, C. J. Allegra, J. Willey, L. Iovino, M. R. Green
Journal: Journal of Clinical Oncology (2008)

7547 Background: Since 2003 there has been level I evidence that adjuvant (adj) cisplatin-based (cis) chemotherapy (CT) significantly improves overall survival (OS) compared to observation (Obs) in patients with completely resected stages II - IIIA non-small cell lung cancer (NSCLC). There has been no similar evidence for completely resected stage IB disease. At ASCO 2004, preliminary data from CALGB 9633, a randomized phase III comparison of adj paclitaxel-carboplatin (PC) or Obs after complete resection in patients with stage IB disease, showed a significant OS advantage for adj PC. More mature data from CALGB 9633 presented at ASCO 2006 no longer demonstrated a significant OS benefit. We studied the impact of the CALGB data on the use of adj CT regimens by American medical oncologists for patients with completely resected stage II NSCLC. Methods: 1,155 medical oncologists participated in 14 live, case-based, research events held between March 2005 and October 2007. We assessed adj therapy plans selected by the participants from options ranging from Obs to 4 cycles of adj CT followed by radiation or prolonged oral receptor tyrosine kinase inhibitor administration. Results: Between March 2005 and June 2006, 76% (293/385) of respondents selected adj therapy with a carboplatin-based (carbo) doublet, including 58% (223/385) selecting PC compared to 21% (81/385) selecting a cis regimen. 3% did not select a systemic therapy. Following ASCO 2006, 51% (393/770) chose a carbo doublet, including 33% (254/770) PC, while 43% (331/770) selected a cis regimen. During the same two intervals, vinorelbine-platinum adj therapy selection rose from 6% to 21%. Conclusions: A significant change in plans for adj regimen for stage IIB NSCLC occurred after ASCO 2006. To our knowledge, apart from the CALGB 9633 update, no other large trial was presented or published during that interval. The presentation of the maturing results of CALGB 9633 at the 2006 ASCO Annual Meeting had a rapid and durable effect on adj chemotherapy selection among US oncologists treating patients with completely resected stage II NSCLC. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration NMCR Analytics
Topics in Paediatric Gastroenterology
Authors: John A. Dodge
Journal: Gut (1977)

This book reports on the papers and discussion at a symposium of which the date and site are unfortunately not men- tioned in the book. (On inquiry, the pub- lishers tell us that it was held at the Welsh National School of Medicine on 7, 8, and 9 July 1975 and that it was a Postgraduate Course in paediatric gastro- enterology organised by J. A. Dodge).It covers development of the gut in the fetus and young children; infancy and its problems; diarrhoea; abdominal pain, and constipation.It conveniently brings together much valuable scattered infor- mation, but the price seems high for a paperback.