tbuckley/cabot-search huggingface dataset:
Relapse after cognitive behavior therapy of depression: potential implications for longer courses of treatment
Authors: M E Thase, A D Simons, J McGeary, J F Cahalane, C Hughes, T Harden, E Friedman
Journal: American Journal of Psychiatry (1992)

The authors studied the risk of relapse among depressed patients after cognitive behavior therapy in order to document the need and potential indications for longer-term models of treatment.Forty-eight patients with major depression who responded during a 16-week course of cognitive behavior therapy entered a 1-year prospective follow-up study, as did two patients who received 20 weeks of therapy. Standardized, independent clinical assessments were completed 1, 3, 6, 9, and 12 months after treatment. Relapse was defined as, at minimum, a 2-week period in which the subject met the DSM-III-R criteria for major depression and had a Hamilton depression scale score of 15 or more.Sixteen patients (32%) relapsed during the 1-year follow-up. Correlates of relapse included a history of depressive episodes, higher levels of depressive symptoms and dysfunctional attitudes, slower response to therapy, and being unmarried. Patients who fully recovered during therapy (Hamilton depression score of 6 or less for 8 weeks or more) were at significantly lower risk for relapse than those who partially recovered (9% and 52%, respectively). Slower response to therapy, unmarried status, and high residual scores on the Dysfunctional Attitudes Scale were independently and additively related to increased risk of relapse.These findings provide further evidence of a relation between residual symptoms and relapse after cessation of active treatment. The authors strongly recommend that models of longer-term psychotherapy be developed for depressed patients who do not recover fully during time-limited cognitive behavior therapy.
Phrenic Nerve Injury After Atrial Fibrillation Catheter Ablation
Authors: Frédéric Sacher, Kristi H. Monahan, Stuart P. Thomas, Neil Davidson, Pedro Adragao, Prashanthan Sanders, Mélèze Hocini, Yoshihide Takahashi, Martin Rotter, Thomas Rostock, Li-Fern Hsu, Jacques Clémenty, Michel Haïssaguerre, David L. Ross, Douglas L. Packer, Pierre Jaïs
Journal: Journal of the American College of Cardiology (2006)
Risks of Smallpox Vaccination
Authors: Vincent A Fulginiti
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clonal Leukemic Evolution In Myelodysplastic Syndromes With ASXL1 and EZH2 mutations: A Comparative Analysis Of 58 Paired Samples
Authors: Hsuan-Jen Shih, Lee-Yung Shih, Hung Chang, Ming-Chung Kuo, Tung-Huei Lin, Chen-Yu Lai, Yu-Shu Shih, Yu-Hui Huang, Tung-Liang Lin, Po-Nan Wang, Jin-Hou Wu
Journal: Blood (2013)
Treatment of Severe Cyclical Mastalgia
Authors: A C V Montgomery, S Biswas, B V Palmer, J C M P Monteiro
Journal: Journal of the Royal Society of Medicine (1979)

In a sequential study to compare the efficacy of bromocryptine and danazol in the treatment of severe cyclical mastalgia, 70% of patients in both groups were relieved of their symptoms. Patients tended to prefer bromocryptine because of its limited side effects. There was a significant fall in prolactin levels with bromocryptine, but not with danazol.
Abstract 843: Restrictive Cardiomyopathy Linked cTnI Mutation (K178E) Causes Severe Heart Failure and Early Mortality
Authors: Pierre-Yves Jean-Charles, Jianfeng Du, Yuejin Li, Nariman Gobara, Xupei Huang
Journal: Circulation (2008)

Multiple mutations in cardiac troponin I (cTnI) have been linked to the development of restrictive cardiomyopathy (RCM) in human patients. Among them, K178E mutation has the worst clinical phenotype. K178E mutation may influence the inhibitory function through actin binding since previous studies have shown that amino acids number 173–181 bind to actin and increase the inhibitory effect of TnI. We modeled the mutation of lysine 178→glutamate (K178E) in human cTnI by cardiac specific expression of the mutated protein (cTnI 179Glu in mouse sequence) in transgenic mice. Multiple lines were generated with varying degrees of expression to establish a dose relationship. Increased resting tension in isolated cardiac myocytes and decreased myofibrillar compliance were the main manifestations in cellular function measurements. In vivo cardiac function measured by high-resolution ultrasonic imaging and Doppler echocardiography revealed a significant diastolic dysfunction characterized with decrease of left ventricular end diastolic dimension (LVEDD), decreased cardiac ejection fraction (EF) and left ventricular faction of shortening (FS) as well as a decreased cardiac output (CO). Doppler measurements showed a restrictive left ventricular filling pattern, i.e. reversed E/A ratio; decreased deceleration time (DT); decreased isovolumic relaxation time (IVRT). Enlarged left and right atria was a dramatic sign, which was observed in most of the transgenic mice, and was developed early and fast (at age of 2–3 weeks). Severely affected lines developed a pathology similar to that observed in human restrictive cardiomyopathy patients who carry the same mutation and with a high early mortality. Our data indicate the causality of this mutation for diastolic dysfunction and heart failure and provide a useful animal model for further understanding the thin filament structure-function relationships and the physiological function of triponin in cardiac contraction and relaxation. (Supported by NIH GM073621 and AHA0715116B) This research has received full or partial funding support from the American Heart Association, AHA Greater Southeast Affiliate (Alabama, Florida, Georgia, Louisiana, Mississippi, Puerto Rico &amp; Tennessee).
The Microanatomy of the Leukemic Stem Cell Niche in Murine Chronic Myelogenous Leukemia
Authors: Melanie Meister, Joel A Spencer, Juwell Wu, Cher Zhao, Lymperi Stefania, Francesca Ferraro, Cristina Lo Celso, David T. Scadden, Richard A. Van Etten, Charles Lin, Daniela S. Krause
Journal: Blood (2014)
Clinical characteristics of COPD with mild bronchiectasis
Authors: Misuzu Kurahara, Nariaki Kokuho, Hiroki Hayashi, Takeo Ishii, Takashi Motegi, Kumiko Hattori, Kouichi Yamada, Koichiro Kamio, Ahikiko Gemma, Kozui Kida
Journal: European Respiratory Journal (2011)

Aim: We tested the hypothesis that patients who have COPD and develop mild BE have a more deteriorated QOL, exercise capacity, and outcome after 1 year than do patients who have COPD without bronchiectasis (BE).

Methods and subjects: The study population consisted of 204 consecutive patients with COPD. All the patients underwent HRCT of the chest and the following studies: quantitative assessment of bronchiectasis by using the methods reported by Bhalla (1991) and Smith (2010), pulmonary function tests, 6-minute walking test, and assessment for QOL. The outcomes for acute exacerbations were evaluated for 1 year.

Results: The study included 204 patients (men, 189; women, 15) with a mean age of 71.2 years. The prevalence of BE in the patients was 27% (n = 55), and the frequency of exacerbations (FE) was 0.49 per year for 70 of the patients. On adjusting for FEV1%, age, and gender, it was found that the patients who had COPD and BE had significantly risk of FE than did those who had COPD without BE (p < 0.02). Visual analogue scale-QOL assessments indicated a trend towards deteriorated QOL for patients with BE with regard to social activity alone. The fat free mass index for patients with BE was significantly lower than that for patients without BE (p <0.02). These data were almost similar for the 2 different assessments performed using the methods reported by Bhalla and Smith.

Conclusions: The patients who had COPD with mild BE had greater likelihood of acute exacerbation than did the patients who had COPD without BE. This characterized phenotype of COPD that is attributed to BE should be evaluated for chronic management even in mild cases of BE.
Hepatocellular Carcinoma: KiSS-1 Overexpression as a Prognostic Factor
Authors: Katharina Schmid, Isabella Mosberger, Fritz Wrba
Journal: Liver Cancer (2009)

Knowing about reliable prognostic markers is of great clinical importance to predict relapse and dissemination of hepatocellular carcinoma (HCC), one of the most common malignant diseases worldwide. It is well known that surgery serves as the only curative therapy; by the end of the last century, orthotopic liver transplantation had become an optional treatment for a subgroup of patients with low tumor stage, resulting in better prognosis with regard to tumor recurrence (Island et al., 2005). Lee et al. (1996) reported for the first time that the KiSS-1 gene, mapped to chromosome 1q32–q41, functions as a metastasis suppressor gene. This working group found that KiSS-1 mRNA expression occurred only in nonmetastatic, but not in metastatic melanoma. Lee and Welch (1997) also observed that the expression of KiSS-1 reduced the metastatic potential of human breast carcinoma cells by 95%, while tumorigenicity was not affected.
Clinical course of idiopathic pulmonary fibrosis (IPF): Prediction and outcome
Authors: Corina Probst, Elena Bargagli, Paola Rottoli, Florian Kollert, Kerstin Höhne, Gernot Zissel, Joachim Müller-Quernheim, Antje Prasse
Journal: European Respiratory Journal (2011)

Background: IPF is a progressive disease for which a median survival time of 2.8 years was reported. However the clinical course of IPF is variable. Acute exacerbation (AE) is a major cause of death in IPF, but only a minority of patients develop AE.

Objectives: The aim of this study was to examine different clinical courses of IPF and to evaluate associated risk factors and predictors.

Methods: We retrospectively studied 85 consecutive patients diagnosed with IPF based on the criteria of the ATS/ERS consensus statement. Clinical data and serial pulmonary function tests were obtained. In accordance to King et al. (King, TE et al. AJRCCM 2011; 183:431-40) patients were grouped to four clinical phenotypes: stable disease, slowly progressive, rapid progressive to death or mixed course. Furthermore, AEs as defined by the criteria of Collard et al. (Collard, HD et al. AJRCCM 2007; 176:636-643) were reported. Serial serum CCL18 concentrations were measured by ELISA.

Results: AE occurred in 34 (40%) patients, with multiple episodes in 6 (7%) patients. The 5-yr survival rate of IPF patients with and without AE was 15% and 41%. Baseline CCL18 serum concentrations differed significantly between the four clinical phenotypes (p<0.0001). IPF patients with a rapid progressive or mixed course showed higher CCL18 serum concentrations (p<0.0001), lower FVC predicted (FVC<60%; p=0.0156) and lower TLC predicted (p=0.002). Stepwise multivariate regression analysis of all patients revealed that CCL18 serum concentration (p=0.016) was independently associated with AE.

Conclusions: We demonstrate that baseline serum CCL18 levels are elevated in IPF patients prone to AE and predict a rapid progressive or mixed course of IPF.
Abstract 5695: Arrhythmogenic Cardiac Death in Implantable Cardioverter Defibrillator Recipients: A Long-term Study of 783 Consecutive Patients
Authors: Gabor Z Duray, Jörn Schmitt, Stefanie Goβ, Panja Berkhoff, Patrick Khattar, Sule Cicek-Hartvig, Carsten W Israel, Stefan H Hohnloser
Journal: Circulation (2008)

Introduction: Long-term mortality and cause of mortality of ICD recipients who are not enrolled in controlled clinical trials are not well known. This study seeked to determine cause-specific mortality in a large sample of unselected ICD recipients. Methods: Consecutive ICD recipients followed at a tertiary referral center at regular 3-month intervals were included. In cases of missed visits, pts, their relatives and their family physicians were contacted. Based on all available evidence, causes of death were classified as cardiac arrhythmic (C–A), cardiac non-arrhythmic (C-NA), non cardial (non-C) and unknown. Results: A total of 783 pts (primary prevention of sudden death in 252, secondary prevention in 531) were followed for 43 ± 30 months, during which time 193 pts died (24.7%, annual mortality 6.7%). Causes of death are shown in the figure . Cox regression analysis revealed that all-cause morality was significantly affected by age (odds ratio 1.03, 95% confidence interval 1.01–1.05), LVEF (0.98, 0.96 – 0.99), NYHA &gt; II (2.1, 1.35–3.26) at baseline, while ICD indication and development of electrical storm had no independent impact on all cause mortality. Predictors for arrhythmic mortality were LVEF (0.96, 0.91– 0.99), NYHA &gt; II (5.3, 1.4 –19.6) spontaneous VT (9.9, 2.1– 45.2) or inducible VT (9.5, 2.0 – 44.2) as indication for ICD therapy. Conclusion: In this unselected group of ICD recipients the mortality over 3.5 years was 25 %. Despite device therapy, at least 14% of patients died from presumably arrhythmic causes. Risk factors associated with arrhythmic mortality were a history of spontaneous or inducible monomorphic ventricular tachycardia, LVEF and higher NYHA class.
Medical Training in the U.S.S.R
Authors: H J LEHMANN
Journal: BMJ (1964)

Leading Articles degree of enzyme defect might thus be magnified, and subsequently the degree of anoxia would be sufficient to stimulate over-production of the putative pressor substance.If this hypothesis were correct-and it is supported by the recent observation of increased 5-hydroxytryptamine in placentas from toxaemic patients3 -the administration of drugs that inhibit monoamine oxidase to pregnant subjects should give rise to toxaemia.This is not the case.31Perhaps these drugs do not cross the placental barrier, for J. M. Robson and J. B. Senior33 were unable to detect any increase in the concentration of 5-hydroxytryptamine in the placentas of animals treated with monoamine-oxidase inhibitors when compared with controls.An alternative explanation for Robson and Senior's findings might be a placental deficiency of L-aromatic amino-acid decarboxylase,"4 a widely distri- buted mammalian enzyme that is responsible for the synthesis of most of the important biologically active amines, including 5-hydroxytryptamine. E. W. Page35 thought that this enzyme did not occur in the human placenta, but as it has been found in the placentas of other mammals"6 this finding should be confirmed.If decarboxylase activity was found to be present an obvious therapeutic approach would be to administer enzyme-blocking drugs to patients with toxaemia to try to break Sandler's " vicious circle " and to reduce the synthesis of 5-hydroxytryptamine and other active amines by the placenta.Though there are not so many inhibitors of de- carboxylase37 as there are of monoamine oxidase, methyl- dopa," a hypotensive agent, inhibits decarboxylase and appears to have some beneficial effect in toxaemia.39Studies on amine transfer in man4 41 are in their early stages, but further investigations might lead to the eventual solution of the problem of toxaemia of pregnancy.
Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction
Authors: Yun Yang, Chunying Shi, Xianglin Hou, Yannan Zhao, Bing Chen, Bo Tan, Zongwu Deng, Qingguo Li, Jianzhou Liu, Zhifeng Xiao, Qi Miao, Jianwu Dai
Journal: Journal of Controlled Release (2015)
The Extra-Cerebral Causes of Epilepsy
Authors: T. H. Weisenburg
Journal: Annals of Internal Medicine (1928)

Article1 July 1928The Extra-Cerebral Causes of EpilepsyT. H. WEISENBURG, M.D.T. H. WEISENBURG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-1-104 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA neurologist is consulted perhaps more frequently in regard to epilepsy than any other disease. At least, that has been my experience. Therefore the subject of the extra-cerebral causes of epilepsy is not without interest. As a preparation for this paper one of my assistants looked up the subject in various text books and more recent papers, and the number and variety of causes is astonishing. From this list it would seem that any cause may produce fits, for every disease and every possibility has been mentioned in the literature.In view of this fact I thought it would be... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia*Read before the American College of Physicians, New Orleans, March 7, 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Epilepsie im KindesalterCholestatic vertigo 1 July 1928Volume 2, Issue 1Page: 104-107KeywordsEpilepsy ePublished: 1 December 2008 Issue Published: 1 July 1928 PDF downloadLoading ...
Physical rehabilitation in asthma management
Authors: Natalia Astafieva, Denis Kobzev, Inna Gamova, Irina Perfilova, Ekaterina Udovichenko
Journal: European Respiratory Journal (2011)

Background: 50% of asthma patients experiences limitations in physical activity and usual lifestyle. Gymnastics can provide significant health benefits and improve quality of life.

Objective: To investigate effects of gymnastics on asthma patients, specifically leading to ameliorated lung function.

Methods: A prospective, randomized, controlled trial was performed to evaluate the effect of respiratory gymnastics (RG). 85 patients with moderate/severe asthma were randomly assigned to control (CG - 16 persons, standard therapy) or RG (RGTG - 69 persons, standard therapy & RG) group; with no significant difference in demographics. Patients were instructed how to practice exercises and examined in 3-6-9-12 months for pulmonary function, cardiopulmonary exercise and control of asthma.

Results: 12 month physical rehabilitation (with pharmacotherapy) reduced: the frequency of complaints; clinical manifestations of asthma; symptoms: daytime (from 94.0% to 28.0%; p = 0.0001) and night (from 54,7% to 7,1%; p = 0,0001); the consumption of β2-agonists (from 3,2 to 2,1 puffs/week). RGTG group increased: FEV1 (from 1,3 to 1,7 L); PEF (from 338,6±19,5 to 403,5±15,8); exercise capacity (W/kg) from 0.85±0.1 to 1.4±0.1. The number of patients with limited physical activity decreased from 86.0±5.0 to 22.0±5.9%; p = 0,001. Heart rate and blood pressure recovery time after exercise decreased from 10,4±0,7 to 9,1±0,6 min (p <0,05). CG changes were much lower (difference between groups was significant, p < 0,001).

Conclusions: Individual programs of RG reduced asthma symptoms and the use of bronchodilator medication in patients with asthma, and can be effective as an adjuvant therapy and optimize asthma patients medical treatment.
Forty Years On
Authors: A. H. Morley
Journal: BMJ (1955)

I have not found that nicotine aggravates the symptoms of Parkinsonism.In Case 1 diethazine appeared to have no effect: in Cases 2 and 3 it aggravated the ataxia.Case 3 actually had to retire to bed for a few days with severe ataxia, and he considered that diethazine was more harmful than nicotine.Although nicotine has no known therapeutic value its usefulness as a pharmacological "tool" has long been appreciated.The observations here recorded suggest that the effects of the drug on the central nervous system in health and disease require further examination. SummaryAn account is given of four patients with spino- cerebellar ataxia who complained of the adverse effect of tobacco-smoking on their disability.The diagnosis in the first three patients is one of progressive spino- cerebellar degeneration; the fourth has disseminated sclerosis.The correctness of their observations was confirmed.Tobacco-smoking had a striking effect on the dysarthria and on the ataxia of the lower limbs in Cases 1 and 3.In Cases 2 and 4 speech was not affected, but ataxia was noticeably increased.These effects were also produced in each patient by the intravenous injection of nicotine acid tartrate.It is suggested that they are brought about by some action of nicotine on the central nervous system which may involve disturbance of synaptic transmission of nerve impulses.Tobacco-smoking and intravenous nicotine had no harmful effect in eight other patients with progressive spinocerebellar degeneration.They were also harmless in 20 patients suffering from various organic diseases of the brain and spinal cord.I wish to thank Dr. E. Payne for carrying out many of the control tests and Drs.G. Howells, A. L. Lewis, and C. Pallis for their assistance in recording the observations.
Relation of Syphilis and Yaws
Authors: C. S. Butler
Journal: Annals of Internal Medicine (1929)

Article1 August 1929Relation of Syphilis and YawsC. S. BUTLERC. S. BUTLERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-2-175 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is doubtful if any other disease has influenced more materially the destinies of the human race than has syphilis. No other human disease punishes ignorance so unerringly and unmercifully as does this one, for it is the only human disease which is commonly carried over from parent to child congenitally.It is certain that for thousands of years mankind has been aware of the fact that this disease was often transmitted by sexual intercourse and it was the stigma of shame, attached to this fact, which made him try to suppress all notice of the disease. For centuries since... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: U.S.N. U. S. Naval School Medical School Washington, D. C.*Lecture and lantern demonstration given to the class in tropical diseases at Georgetown University Medical School, May 3, 1929. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Verbreitung der Syphilis in den TropenSyphilis from the Epidemiologist's Point of View 1 August 1929Volume 3, Issue 2Page: 175-179KeywordsRacial and ethnic issuesSexually transmitted diseasesSyphilisTropical diseases ePublished: 1 December 2008 Issue Published: 1 August 1929 PDF downloadLoading ...
Scientists debate whether sperm counts are really falling
Authors: Janice Hopkins Tanne
Journal: BMJ (1998)

The possible worldwide decline in sperm counts sparked lively debate at a symposium last week entitled Hazardous substances and male reproductive health, which was sponsored by the New York Academy of Medicine and the Mount Sinai School of Medicine in New York.

A reported decline in sperm counts of around 1% a year between 1930 and 1990 attracted wide attention when it was reported by Dr Niels Skakkebaek, from the Rigshospitalet in Copenhagen ( BMJ 1992;305:609-13). However, a reanalysis of data in the paper showed there was no worldwide decline, said Dr Harry …