tbuckley/cabot-search huggingface dataset:
Efficacy and Safety of Rilzabrutinib in Patients With Chronic Spontaneous Urticaria: 12-Week Results From the RILECSU Phase 2 Dose-Ranging Study
Authors: Marcus Maurer, Ana Gimenez-Arnau, Silvia Ferrucci, Vincent Mikol, Iris Sun, Leda Mannent, Jessica Gereige
Journal: Journal of Allergy and Clinical Immunology (2024)
IgE Binding and Cross-reactivity to Linear and Conformational Epitopes of Peanut and Walnut Vicilin-buried Peptides
Authors: Lauren Swientoniewski, Ian Rambo, Jacqueline Nesbit, Hsiaopo Cheng, Stephen Gipson, Stacie Jones, Stephen Dreskin, Shahzad Mustafa, Scott Smith, Geoffrey Mueller, Soheila Maleki
Journal: Journal of Allergy and Clinical Immunology (2024)
Indoor Fungal Mixtures, Asthma and Seroatopy Among School-age Children Living in New York City
Authors: Adnan Divjan, Karen Dannemiller, Samuel Cochran, Luis Acosta, Lori Hoepner, Andrew Rundle, Julie Herbstman, Frederica Perera, Rachel Miller, Matthew Perzanowski, Tiffany Sanchez
Journal: Journal of Allergy and Clinical Immunology (2024)
Lipidomic Analysis of Epithelium Reveals Unique Sphingolipid Profile in Eosinophilic Esophagitis with Potential Implications for Esophageal Barrier Dysfunction
Authors: Melinda Braskett, Elena Goleva, Irina Bronova, Gautam Nagendra, Ramon Durazo-Arvizu, Nick Shillingford, Harry Cynamon, Mika Warren, Vrinda Bhardwaj, Peck Ong, Donald Leung, Evgeny Berdyshev, Katherine Lyubchenko
Journal: Journal of Allergy and Clinical Immunology (2024)
The Potential Role of Oro-Mucosal Fruit Challenges: A Less-invasive and Efficient Approach to Investigate IgE-mediated Banana Allergies
Authors: Irin Vichara-Anont, Torpong Thongngarm, Chamard Wongsa, Thanachit Krikeerati, Piyaporn Chokevittaya, Mongkhon Sompornrattanaphan
Journal: Journal of Allergy and Clinical Immunology (2024)
Effects of Proton Pump Inhibitors on Esophageal Remodeling and Fibrosis in Eosinophilic Esophagitis
Authors: Colby Sharlin, Yuki Maekawa, Hiroki Sato, Kazuhiro Matsuyama, Seung Kim, Kasumi Osonoi, Naoya Sakai, Garrett Osswald, Mark Rochman, Ting Wen, Evan Dellon, Marc Rothenberg, Tetsuo Shoda
Journal: Journal of Allergy and Clinical Immunology (2024)
Analytical Validation and Stability Studies for Basophil Activation Test to Meet IVDR Certification.
Authors: Collin Shaw, Dominik Vogt, Anna Melone, Martina Berchtold, Christina Bauer, Michele Romano, Michael Schneider, Christian-Benedikt Gerhold, Michael Gerspach, Thomas Schuster
Journal: Journal of Allergy and Clinical Immunology (2024)
Amelioration Of Mrgprb2-Mediated Anaphylactoid Drug Reactions With Briquilimab, An Anti-CD117 Antibody, Through Mast Cell Depletion In Mice Expressing Chimeric Human And Mouse CD117
Authors: Charles Chang, Ajay Sharma, Allison Ji, Revati Nerkar, Kai Martell, Karl Meneses, Hye-Sook Kwon, Wendy Pang
Journal: Journal of Allergy and Clinical Immunology (2024)
Epitope-specific IgE, IgG4, and IgG1 antibodies for clinical phenotyping of IgE-mediated wheat allergy
Authors: Mayte Suárez-Fariñas, Witchaya Srisuwatchari, Andrew Delgado, Galina Grishina, Pakit Vichyanond, Punchama Pacharn, Hugh Sampson
Journal: Journal of Allergy and Clinical Immunology (2024)
Direct Oral Challenge for Low-Risk Sulfonamide Allergy: Safety and Antimicrobial Stewardship Impacts in Hospitalised Patients
Authors: Elise Mitri, Jamie Waldron, Fionnuala Cox, Kyra Chua, Rebecca Hall, Kerryn McInnes, Natasha Holmes, Jason Trubiano
Journal: Journal of Allergy and Clinical Immunology (2024)
Efficacy of Remibrutinib in Patients With Chronic Spontaneous Urticaria With or Without Prior Exposure to Biologics in the Phase 3 REMIX-1 and REMIX-2 Studies
Authors: Giselle Mosnaim, Ana Gimenez-Arnau, Michihiro Hide, Mark Lebwohl, Marcus Maurer, Martin Metz, Sarbjit Saini, Gordon Sussman, Sibylle Haemmerle, Karine Lheritier, El-Djouher Martzloff, Noriko Seko, Pengpeng Wang, Shalia Gogate
Journal: Journal of Allergy and Clinical Immunology (2024)
Sebetralstat for On-demand Treatment of Hereditary Angioedema Attacks: Results of the Double-blind, Placebo-controlled Phase 3 KONFIDENT Trial
Authors: Marc Riedl, Emel Aygören-Pürsün, William Lumry, Henriette Farkas, Andrea Zanichelli, James Hao, Matthew Iverson, Michael Smith, Christopher Yea, Paul Audhya, Jonathan Bernstein, Marcus Maurer, Danny Cohn
Journal: Journal of Allergy and Clinical Immunology (2024)
Is Asthma Clinical Remission Achievable by Inhaled Therapy? A Post-Hoc Analysis of Single Inhaler Triple Therapy with FF/UMEC/VI in the CAPTAIN Trial
Authors: Njira Lugogo, John Oppenheimer, Jodie Crawford, Tom Corbridge, Peter Howarth, Emmeline Igboekwe, Alison Moore, Stephen Noorduyn, David Slade, Stephen Weng, Ian Pavord
Journal: Journal of Allergy and Clinical Immunology (2024)
Ozone and PM2.5 exposure are associated with nasal key driver gene expression in asthma.
Authors: Yoojin Chun, Aritz Irizar, Lingdi Zhang, Zoe Arditi, Galina Grishina, Alexander Grishin, Alfin Vicencio, Supinda Bunyavanich
Journal: Journal of Allergy and Clinical Immunology (2024)
Demographics and Baseline Characteristics of Children With Atopic Dermatitis Enrolled in a Randomized Phase 3 Study (TRuE-AD3)
Authors: Dareen Siri, Lara Wine Lee, Linda Stein Gold, April Armstrong, Kanwaljit Brar, Kristen Holland, Julie Shepard, Alim Devani, Daniel Sturm, Brett Angel, Qian Li, Lawrence Eichenfield
Journal: Journal of Allergy and Clinical Immunology (2024)
ARS-2, Low-Dose Intranasal Epinephrine, Improves Urticaria Scores in Patients with Frequent Urticaria Flares: Phase 2 Study Results
Authors: David Bernstein, Neetu Talreja, Thomas Casale, H. Henry Li, Wayne Shreffler, Richard Lowenthal, Sarina Tanimoto
Journal: Journal of Allergy and Clinical Immunology (2024)
Risk-Stratification Identifies Low-Risk Fluoroquinolone Allergies Suitable for Direct Oral Challenge
Authors: Irene Yuan, Anna Brameli, Matthew Krantz, David House, Elizabeth Phillips, Cosby Stone
Journal: Journal of Allergy and Clinical Immunology (2024)

Fluoroquinolones are rarely associated with IgE-mediated reactions, and skin tests are difficult to interpret due to MRGPRX2 activation and dose-dependent non-IgE mediated mast cell degranulation. Previous studies for non-beta lactam antibiotics (e.g. sulfonamides) have used history-based risk stratification to assess for and successfully delabel low-risk patients by direct oral challenge, which forms the basis for revised practice parameter guidelines. We examined a risk-stratified approach for fluoroquinolone allergy delabeling.
A Streamlined Approach to Basophil Activation Testing for Longitudinal Characterization of Toddlers with Peanut Allergy During a Multi-Site Phase 3 Double-Blind Placebo-Controlled Trial of Epicutaneous Immunotherapy (EPIT)
Authors: Alexander Grishin, Rihane Arif-Lusson, Penelope Bourgoin, Katie Matthews, Dianne Campbell, Henry Bahnson, Jean-Marc Busnel, Hugh Sampson
Journal: Journal of Allergy and Clinical Immunology (2024)
Baseline Demographics And Disease Characteristics Of Pediatric Patients With Eosinophilic Esophagitis (EoE) From The Randomised, Placebo-Controlled, Phase 3 EoE KIDS Study
Authors: Mirna Chehade, Christopher Parrish, Jonathan Spergel, Ruiqi Liu, Eric Mortensen, Elizabeth Laws, Jennifer Maloney, Renata Martincova, Lila Glotfelty, Arsalan Shabbir
Journal: Journal of Allergy and Clinical Immunology (2024)
Trial Characteristics of Randomized Controlled Trials Evaluating Bronchial Thermoplasty in Moderate and Severe Asthma: An AAAAI/ACAAI JTFPP Systematic Review
Authors: Leonardo Ologundudu, Nazmul Islam, Daniel Rayner, Sharmilee Nyenhuis, Flavia Hoyte, Elliot Israel, John Oppenheimer, Bradley Chipps, Katherine Rivera-Spoljaric, Kaharu Sumino, Tamara Perry, Giselle Mosnaim, Leonard Bacharier, Matthew Rank, Derek Chu
Journal: Journal of Allergy and Clinical Immunology (2024)
Sex Differences On The Effect Of Sinus Surgery On The Development Of Asthma In Patients With Chronic Rhinosinusitis
Authors: Yasmeen Ali, Thanh-Huyen Vu, Whitney Stevens, Arnaud Wautlet, Ethan Chung, Nicole Altomare, David Conley, Leslie Grammer, Atsushi Kato, Robert Kern, Robert Schleimer, Brian Schwartz, Stephanie Smith, Bruce Tan, Kevin Welch, Alexander Nemeth
Journal: Journal of Allergy and Clinical Immunology (2024)
Early Life Wheezing and Childhood Cognition in the Environmental Influences on Child Health Outcomes (ECHO) Program
Authors: Sima Ramratnam, Eric Seaberg, Michael O'Shea, Flory Nkoy, Augusto Litonjua, Susan Korrick, Rachel Kelly, Robert Joeseph, Su Chu, Elizabeth Jensen, Diane Gold, Kecia Carroll, William Gower, Matthew Perzanowski, James Gern
Journal: Journal of Allergy and Clinical Immunology (2024)
Effect of biologic treatment in uncontrolled severe chronic rhinosinusitis with nasal polyps in Belgium: A Real-World Data study
Authors: An-sofie Viskens, Laura Bollen, Elien Borgers, Florence Rogister, Stijn Halewyck, Valerie Hox, Mark Jorissen, Winde Lemmens, Kato Speleman, Laura Van Gerven, Olivier Vanderveken, Benedicte Verhaeghe, Peter Hellings
Journal: Journal of Allergy and Clinical Immunology (2024)
Differences In Viral Respiratory Tract Infections Among Immunodeficiency Patients And The General Population After The COVID-19 Pandemic
Authors: Joseph Chiao, Alex Chi, Christen Pahk, Erin Chen, Grace Gao, Catherine Xiao, Nathan Wetherby, Amy Tran, Keith Wetherby, Shaobin Hou, Huamin Li
Journal: Journal of Allergy and Clinical Immunology (2024)
Relevance of Human IgE Monoclonal Antibodies within the IgE Repertoire to Dust Mite Allergen Der p 2
Authors: Alyssa Ball, Kriti Khatri, Jill Glesner, Lisa Vailes, Sabina Wünschmann, Scott Gabel, Geoffrey Mueller, Jian Zhang, Stokes Peebles, Martin Chapman, Scott Smith, Maksymilian Chruszcz, Anna Pomes
Journal: Journal of Allergy and Clinical Immunology (2024)
The association of cytokines in nasal epithelial lining fluid (nELF) with asthma outcomes differ between normal weight and overweight/obese children
Authors: Anna Qiu, Emily Brigham, John Woo, Nadia Hansel, Rachelle Koehl, Neil Alexis, Meghan Rebuli, Meredith McCormack
Journal: Journal of Allergy and Clinical Immunology (2024)
Eosinophilic Esophagitis (EoE): A Review of Diagnosis, Treatment, and Compliance at a Pediatric Tertiary Care Center
Authors: Serina Beydoun, Wimwipa Mongkonsritragoon, Ananya Varre, Logan Gary, Rahul Revan, Pavadee Poowuttikul, Divya Seth
Journal: Journal of Allergy and Clinical Immunology (2024)
Pediatric Asthma Post Hospitalization Phone Calls Increase Parental Self-Efficacy and Reduce 90 Day Emergency Department Visits
Authors: Abigail Kleinschmidt, Meghan Senior, Erin Arcipowski, Melissa Korenblat-Hanin, Cirese Webster, Patrick Ercole, Patricia Gyr, Kathryn Quirin, Alissa Haycraft, Courtney Moore, Jennifer Broeder, Lisa Steurer
Journal: Journal of Allergy and Clinical Immunology (2024)
A Galectin-9–Driven CD11c <sup>high</sup> Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia
Authors: Yanhong Li, Yifei Sang, Yunjian Chang, Chunfang Xu, Yikong Lin, Yao Zhang, Philip C.N. Chiu, William S.B. Yeung, Haisheng Zhou, Ningzheng Dong, Ling Xu, Jiajia Chen, Weijie Zhao, Lu Liu, Di Yu, Xingxing Zang, Jiangfeng Ye, Jinying Yang, Qingyu Wu, Dajin Li, Ligang Wu, Meirong Du
Journal: Circulation (2024)

Preeclampsia is a serious disease of pregnancy that lacks early diagnosis methods or effective treatment, except delivery. Dysregulated uterine immune cells and spiral arteries are implicated in preeclampsia, but the mechanistic link remains unclear.
Diagnostic accuracy of inflammatory markers in adults with suspected central nervous system infections
Authors: Sabine E. Olie, Steven L. Staal, Liora ter Horst, Ingeborg E. van Zeggeren, Wing K. Man, Michael W.T. Tanck, Diederik van de Beek, Matthijs C. Brouwer
Journal: Journal of Infection (2024)

We aimed to determine diagnostic accuracy of inflammatory markers in plasma and cerebrospinal fluid (CSF) for the diagnosis of central nervous system (CNS) infections and specifically bacterial meningitis.
Comparison of safety and efficacy for peanut and tree nut oral immunotherapy (OIT) by age: infant OIT (iOIT) less then 12 months versus toddler OIT (tOIT) 1-4 years of age
Authors: Ahila Subramanian, Rachel Whitsel, Kara McNamara, Jaclyn Bjelac, Sandra Hong
Journal: Journal of Allergy and Clinical Immunology (2024)
Healthcare resource utilization and costs in patients with eosinophilic granulomatosis with polyangiitis versus severe uncontrolled asthma: a retrospective analysis of US health insurance claims data
Authors: Paul Dolin, Danuta Kielar, Anat Shavit, Karina Keogh, Jennifer Rowell, Chris Edmonds, Juliana Meyers, Elizabeth Esterberg, Tram Nham, Stephanie Chen
Journal: Journal of Allergy and Clinical Immunology (2024)
Risk Factors And Challenge Outcomes In Trimethoprim-Sulfamethoxazole Allergy: A Multicenter Retrospective Report.
Authors: Susan Kinate, Dayne Voelker, Christine Rukasin, Ebram Labib, Gonzalo Labarca, Matthew Rank, Miguel Park, Alexei Gonzalez-Estrada
Journal: Journal of Allergy and Clinical Immunology (2024)
A multidisciplinary approach to unraveling genetic forms of immune dysregulation in children with refractory multilineage cytopenia
Authors: Yael Gernez, Bindu Sathi, Juanita Valdes Camacho, Latha Rao, Berthil Glader, Deepika Singh, Elisabeth Hoyte, David Lewis, Maria Grazia Roncarolo, May Chien, Rosa Bacchetta, Katja Weinacht
Journal: Journal of Allergy and Clinical Immunology (2024)
Added diagnostic value of extended-day over single-day drug provocation test for confirming or delabeling beta-lactam hypersensitivity reaction: A systematic review and meta-analysis
Authors: Prapasri Kulalert, Phichayut Phinyo, Anca Mirela Chiriac, Pascal Demoly, Surasak Saokaew, Kantima Kanchanaphoomi, Witchaya Srisuwatchari
Journal: Journal of Allergy and Clinical Immunology (2024)
Association between Leukotriene A4 Hydrolase Genetic Variants and Urticaria/Angioedema to Nonsteroidal Anti-inflammatory Drugs
Authors: Raquel Jurado-Escobar, Inmaculada Dona Diaz, Isabel María Jiménez-Sánchez, María Salas-Cassinello, Inmaculada Mena, Joan Bartra, Jose Julio Laguna, Rocio Saenz de Santamaria-Garcia, Maria Jose Torres, Jose Antonio Cornejo-Garcia
Journal: Journal of Allergy and Clinical Immunology (2024)
Prevalence of NSAID-ERD Among Patients with Chronic Rhinosinusitis with Nasal Polyps in the Global AROMA registry
Authors: Martin Desrosiers, Tanya Laidlaw, Andrew White, Eugenio De Corso, Anju Peters, Scott Nash, Changming Xia, Micah Johnson, Lucia De Prado Gomez, Paul Rowe, Yamo Deniz, Juby Jacob-Nara, Harry Sacks
Journal: Journal of Allergy and Clinical Immunology (2024)
Establishment of an Innovative Preclinical Mouse Model for Advanced Systemic Mastocytosis
Authors: Martina Konantz, Alina Makeeva, Elena Ratti, Laetitia Clauss, Etnik Sheremeti, Ewelina Bartoszek, Simona Stivala, Karin Hartmann
Journal: Journal of Allergy and Clinical Immunology (2024)
Wildfire Smoke Exposure during SARS-CoV-2 Vaccination Impairs Immunity via Natural Killer Cell derived IL-13
Authors: Gursharan Kaur Sanghar, Melissa Teuber, Resmi Ravindran, Emma Keller, Pedro Hernandez, Sophie Krauss, Angela Linderholm, Gabrielle Echt, Kaelyn Tuermer-Lee, Maya Juarez, Timothy Albertson, Imran Khan, Angela Haczku
Journal: Journal of Allergy and Clinical Immunology (2024)
Low-Dose Oral Wheat Challenge Contributes to Early Tolerance Acquisition in Children with Wheat Allergy: A Propensity Score Matched Retrospective Cohort Study
Authors: Yuki Chiba, Takaaki Itonaga, Kyohei Takahashi, Yumi Koike, Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa
Journal: Journal of Allergy and Clinical Immunology (2024)
Pediatric ECG-Based Deep Learning to Predict Left Ventricular Dysfunction and Remodeling
Authors: Joshua Mayourian, William G. La Cava, Akhil Vaid, Girish N. Nadkarni, Sunil J. Ghelani, Rebekah Mannix, Tal Geva, Audrey Dionne, Mark E. Alexander, Son Q. Duong, John K. Triedman
Journal: Circulation (2024)

Artificial intelligence-enhanced ECG analysis shows promise to detect ventricular dysfunction and remodeling in adult populations. However, its application to pediatric populations remains underexplored.
Demographic Variation in Different Phenotypes of Severe Cutaneous Adverse Reactions: An Eight-Year Prospective Cohort Study
Authors: Jettanong Klaewsongkram, Pattarawat Thantiworasit, Supranee Buranapraditkun, Pungjai Mongkolpathumrat
Journal: Journal of Allergy and Clinical Immunology (2024)
Human Myeloid Dendritic Cells (mDCs) exposed to Interleukin-4 (IL-4) secrete CCL17 and recruit Memory T lymphocytes
Authors: John Altpeter, Carol Brenner-Webster, Rachel Idol, Kathrine O'Connor, Sourav Bhattacharya, Irene Yuan, Michelle Gill
Journal: Journal of Allergy and Clinical Immunology (2024)
Dupilumab Normalized The Expression Of Genes Dysregulated In Eosinophilic Esophagitis (EoE) In Esophageal Biopsies From A Clinical Trial Of Children Aged 1–11 Years
Authors: Marc Rothenberg, Wei Keat Lim, Matthew Wipperman, Mirna Chehade, Evan Dellon, Navneet Virk Hundal, Shauna Schroeder, Christopher Parrish, Ruiqi Liu, Elizabeth Laws, Eric Mortensen, Lila Glotfelty, Arsalan Shabbir, Alexandra Hicks, Jennifer Hamilton
Journal: Journal of Allergy and Clinical Immunology (2024)
Zip Codes with High Pediatric Asthma Hospital Encounters are Areas with Increased Social Needs – Lessons From Geo-Mapping Technology
Authors: Serina Beydoun, Wimwipa Mongkonsritragoon, Dana Al-Maajali, Emman Dabaja, Pavadee Poowuttikul, Jenny Huang
Journal: Journal of Allergy and Clinical Immunology (2024)
Hypoallergenic Safety Profile of a Novel Virus-like Particle Vaccine for the Treatment of Peanut Allergy supported by Skin Prick Testing
Authors: Pieter-Jan de Kam, Roxanne Oriel, Thomas Casale, Kemi Oluwayi, Silvia Meneghesso, David Wilkie, Sema Eser, Marietta Krebs, Lena Oppenlaender, Eamonn McArdle, Matthias Kramer, Simon Hewings, Murray Skinner
Journal: Journal of Allergy and Clinical Immunology (2024)
Maternal Transcriptomic Profiles and Phenotypes of Childhood Wheeze in the Breathe-Wellbeing, Environment, Lifestyle and Lung function (B-WELL-Mom) study
Authors: Madeline Schutt, Nathan Jackson, Danielle Stevens, Leonoardo Barrera, Emily Golbeck, Matthew Davis, Jennifer Weck, Akila Subramaniam, Joseph Biggio, William Grobman, Seth Sherman, Zhen Chen, Pauline Mendola, Max Seibold, Rajesh Kumar
Journal: Journal of Allergy and Clinical Immunology (2024)
Transitioning from Peanut Allergen Powder-dnfp to Peanuts
Authors: Saad Anjum, Christina Ciaccio
Journal: Journal of Allergy and Clinical Immunology (2024)

Peanut Allergen Powder-dnfp (PAP) is an oral desensitization product approved by the FDA for peanut allergy. After an initial dose escalation phase, continuous exposure to peanut protein maintains desensitization and continued immunomodulation. We hypothesize that transitioning to food products to maintain desensitization after dose escalation is a safe alternative to continuation of PAP. A retrospective chart review at a single urban academic center was conducted. Children ages 4-17 who have undergone oral immunotherapy to peanut using PAP were included. Twenty-eight patients were identified that met study criteria. In all cases, children/parent dyads were given the option of PAP 300mg or a peanut (or peanut M&M) in clinic after consuming at least 2 weeks of PAP 240mg. All dyads opted for a food product. No children showed symptoms of anaphylaxis or a systemic allergic reaction. Seven patients had mild symptoms of mouth discomfort, throat itching, or abdominal pain that self-resolved. One patient had abdominal pain that did not improve with cetirizine but resolved with famotidine. One patient had tongue and throat itching that resolved with cetirizine and food. All children were continued on their chosen food product for the continued immunomodulation phase. This study suggests that transitioning from PAP to food such as a peanut M&M is a safe and inexpensive way to maintain desensitization to peanuts. Further work is needed to understand if long term outcomes are similar, and if food products influence compliance with oral immunotherapy due to convenience, decreased costs, and taste.
Transcriptomic analysis of gastric tissue in pediatric eosinophilic gastritis.
Authors: Ichiro Nomura, Rina Kusuda, Sho Watanabe, Saori Nagashima, Hideaki Morita, Katsuhiro Arai, Yukihiro Ohya, Kenji Matsumoto
Journal: Journal of Allergy and Clinical Immunology (2024)
Predicting Penicillin Allergy from Patient-Reported Data: A Multi-Site Prospective Study from The United States Drug Allergy Registry
Authors: Kimberly Blumenthal, Allison Ramsey, Elizabeth Phillips, Alexei Gonzalez-Estrada, John Accarino, Aleena Banerji, Cosby Stone, Iris Otani, David Khan, Timothy Chow, Anne Liu, Anna Arroyo, Andrew King, Yuqing Zhang
Journal: Journal of Allergy and Clinical Immunology (2024)
Assessment of Safety of Autologous Regulatory T-cells in the Treatment of Systemic Sclerosis
Authors: Anna Malasheuskaya, Andrei Hancharou, Natalia Antonevich, Konstantin Chyzh, Valery Apanasovich, Tatiana Reabzeva, Iryna Butoryna, Lawrence Dubuske
Journal: Journal of Allergy and Clinical Immunology (2024)
The cut-off level of specific IgE against Dermatophagoides farinae in a 3-year-old child with rhinitis symptoms : COCOA study
Authors: Kun Baek Song, Eom Ji Choi, Soo-Jong Hong, So-Yeon Lee, Youn Ho Shin, Dong Suh, Kyung Won Kim, Kangmo Ahn, Eun Young Paek
Journal: Journal of Allergy and Clinical Immunology (2024)
IGNX001 Abrogates Peanut-mediated Mast Cell Degranulation and Murine Anaphylaxis
Authors: Derek Croote, Joyce Wong, Paige Creeks, Venu Aruva, Jessica Grossman, Roger Ferrini, Henry Lowman, Jeffrey Landers, Jessica O'Konek, Roger Thomas
Journal: Journal of Allergy and Clinical Immunology (2024)
Differences Between Children and Adult Patients with Extremely High IgE Levels: One Center Experience
Authors: Rebecca Grohman, Denisa Ferastraoaru, Joshua Hanau, Adam Haines
Journal: Journal of Allergy and Clinical Immunology (2024)

We sought to evaluate if there are any differences in associated conditions and the work-up performed in adults and children with extremely elevated IgE levels (IgE≥10,000 kU/L, eeIgE). Chart review on all patients with eeIgE seen between 1/2015-7/2023 at Montefiore Medical Center, Bronx, NY was performed. Overall, 48 adults (mean age 46.5 years (±21.1), 56.3% male) and 32 children (mean age 8.6 years (±5.4), 62.5% male) were included. Significantly higher rates of atopic dermatitis (AD) were found in children (96.9%) compared with adults (58.3%, p<0.001). Asthma had similar frequency in adults (58.3%) and children (48.4%, p=0.386). Among the 28 adults with asthma, 19 (67%) were evaluated for allergic bronchopulmonary aspergillosis (ABPA) and 3/19 (15.8%) had ABPA. Adults were more frequently tested for S. stercoralis (68.8% vs 18.8%, p<.001) and T. canis (31.3% vs 12.5%, p=0.054) than children, and six adults (18%) had a positive test; all children tested were negative for parasitosis. More adults were evaluated for immunodeficiency (62.5% vs 34.4%, p=0.014). However, genetic testing was performed more frequently in children (18% vs 4.2%, p=0.033). One child and one adult had a diagnosis of autosomal dominant Hyper-IgE Syndrome (AD-HIES). Four patients had chronic rhinosinusitis (CRS), 1 had IgG4 related disease (IgG4-RD) and none had aspirin exacerbated respiratory disease (AERD). Asthma and AD were the most frequent conditions associated with eeIgE, whereas rates of CRS, HIES, IgG4-RD and AERD were low. More consistent workup is needed for patients with eeIgE, especially when evaluating for parasitosis, immunodeficiency and ABPA.
Exploring the Spectrum of Indolent Systemic Mastocytosis: Analysis of High-Risk Disease Features in the PIONEER Study
Authors: Marcus Maurer, Cem Akin, Sigurd Broesby-Olsen, Hanneke Oude Elberink, Tracy George, Frank Siebenhaar, Jason Gotlib, Deepti Radia, Andreas Reiter, Javier Muñoz-González, Kate Newberry, Hui-Min Lin, Ilda Bidollari, Benjamin Lampson, Karin Hartmann
Journal: Journal of Allergy and Clinical Immunology (2024)
Gestational Exposure To Benzene Is Associated With Childhood Asthma Through IL-4 and Oxidative stress : ECHO-COCOA study
Authors: Song-I Yang, Hosub Im, Yong Joo Park, Hoon Je Seong, Hyun Ju Yoo, Jeonghun Yeom, Mi-Jin Kang, So-Yeon Lee, Kangmo Ahn, Kyung Won Kim, Youn Ho Shin, Dong In Suh, Soo-Jong Hong
Journal: Journal of Allergy and Clinical Immunology (2024)