tbuckley/cabot-search huggingface dataset:
Erratum: “Associations of Organophosphate Ester Flame Retardant Exposures during Pregnancy with Gestational Duration and Fetal Growth: The Environmental influences on Child Health Outcomes (ECHO) Program”
Authors: Jiwon Oh, Jessie P. Buckley, Xuan Li, Kennedy K. Gachigi, Kurunthachalam Kannan, Wenjie Lyu, Jennifer L. Ames, Emily S. Barrett, Theresa M. Bastain, Carrie V. Breton, Claudia Buss, Lisa A. Croen, Anne L. Dunlop, Assiamira Ferrara, Akhgar Ghassabian, Julie B. Herbstman, Ixel Hernandez-Castro, Irva Hertz-Picciotto, Linda G. Kahn, Margaret R. Karagas, Jordan R. Kuiper, Cindy T. McEvoy, John D. Meeker, Rachel Morello-Frosch, Amy M. Padula, Megan E. Romano, Sheela Sathyanarayana, Susan Schantz, Rebecca J. Schmidt, Hyagriv Simhan, Anne P. Starling, Frances A. Tylavsky, Heather E. Volk, Tracey J. Woodruff, Yeyi Zhu, Deborah H. Bennett
Journal: Environmental Health Perspectives (2024)
Plasmonic-Driven Regulation of Biomolecular Activity In Situ
Authors: Chen Xie, Tingting Zhang, Zhenpeng Qin
Journal: Annual Review of Biomedical Engineering (2024)

Selective and remote manipulation of activity for biomolecules, including protein, DNA, and lipids, is crucial to elucidate their molecular function and to develop biomedical applications. While advances in tool development, such as optogenetics, have significantly impacted these directions, the requirement for genetic modification significantly limits their therapeutic applications. Plasmonic nanoparticle heating has brought new opportunities to the field, as hot nanoparticles are unique point heat sources at the nanoscale. In this review, we summarize fundamental engineering problems such as plasmonic heating and the resulting biomolecular responses. We highlight the biological responses and applications of manipulating biomolecules and provide perspectives for future directions in the field.
Cardiorespiratory fitness is a strong and consistent predictor of morbidity and mortality among adults: an overview of meta-analyses representing over 20.9 million observations from 199 unique cohort studies
Authors: Justin J Lang, Stephanie A Prince, Katherine Merucci, Cristina Cadenas-Sanchez, Jean-Philippe Chaput, Brooklyn J Fraser, Taru Manyanga, Ryan McGrath, Francisco B Ortega, Ben Singh, Grant R Tomkinson
Journal: British Journal of Sports Medicine (2024)

Objective To examine and summarise evidence from meta-analyses of cohort studies that evaluated the predictive associations between baseline cardiorespiratory fitness (CRF) and health outcomes among adults. Design Overview of systematic reviews. Data source Five bibliographic databases were searched from January 2002 to March 2024. Results From the 9062 papers identified, we included 26 systematic reviews. We found eight meta-analyses that described five unique mortality outcomes among general populations. CRF had the largest risk reduction for all-cause mortality when comparing high versus low CRF (HR=0.47; 95% CI 0.39 to 0.56). A dose–response relationship for every 1-metabolic equivalent of task (MET) higher level of CRF was associated with a 11%–17% reduction in all-cause mortality (HR=0.89; 95% CI 0.86 to 0.92, and HR=0.83; 95% CI 0.78 to 0.88). For incident outcomes, nine meta-analyses described 12 unique outcomes. CRF was associated with the largest risk reduction in incident heart failure when comparing high versus low CRF (HR=0.31; 95% CI 0.19 to 0.49). A dose–response relationship for every 1-MET higher level of CRF was associated with a 18% reduction in heart failure (HR=0.82; 95% CI 0.79 to 0.84). Among those living with chronic conditions, nine meta-analyses described four unique outcomes in nine patient groups. CRF was associated with the largest risk reduction for cardiovascular mortality among those living with cardiovascular disease when comparing high versus low CRF (HR=0.27; 95% CI 0.16 to 0.48). The certainty of the evidence across all studies ranged from very low-to-moderate according to Grading of Recommendations, Assessment, Development and Evaluations. Conclusion We found consistent evidence that high CRF is strongly associated with lower risk for a variety of mortality and incident chronic conditions in general and clinical populations.
Genome-wide DNA methylation-analysis of blastic plasmacytoid dendritic cell neoplasm identifies distinct molecular features
Authors: Axel Künstner, Julian Schwarting, Hanno M. Witte, Pengwei Xing, Veronica Bernard, Stephanie Stölting, Philipp Lohneis, Florian Janke, Maede Salehi, Xingqi Chen, Kathrin Kusch, Holger Sültmann, Emil Chteinberg, Anja Fischer, Reiner Siebert, Nikolas von Bubnoff, Hartmut Merz, Hauke Busch, Alfred C. Feller, Niklas Gebauer
Journal: Leukemia (2024)

Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) constitutes a rare and aggressive malignancy originating from plasmacytoid dendritic cells (pDCs) with a primarily cutaneous tropism followed by dissemination to the bone marrow and other organs. We conducted a genome-wide analysis of the tumor methylome in an extended cohort of 45 BPDCN patients supplemented by WES and RNA-seq as well as ATAC-seq on selected cases. We determined the BPDCN DNA methylation profile and observed a dramatic loss of DNA methylation during malignant transformation from early and mature DCs towards BPDCN. DNA methylation profiles further differentiate between BPDCN, AML, CMML, and T-ALL exhibiting the most striking global demethylation, mitotic stress, and merely localized DNA hypermethylation in BPDCN resulting in pronounced inactivation of tumor suppressor genes by comparison. DNA methylation-based analysis of the tumor microenvironment by MethylCIBERSORT yielded two, prognostically relevant clusters (IC1 and IC2) with specific cellular composition and mutational spectra. Further, the transcriptional subgroups of BPDCN (C1 and C2) differ by DNA methylation signatures in interleukin/inflammatory signaling genes but also by higher transcription factor activity of JAK-STAT and NFkB signaling in C2 in contrast to an EZH2 dependence in C1-BPDCN. Our integrative characterization of BPDCN offers novel molecular insights and potential diagnostic applications.
B-cell characteristics define HCV reinfection outcome
Authors: Alexander P. Underwood, Money Gupta, Bing-Ru Wu, Auda A. Eltahla, Irene Boo, Jing Jing Wang, David Agapiou, Arunasingam Abayasingam, Arnold Reynaldi, Elizabeth Keoshkerian, Yanran Zhao, Nicholas Brasher, Melanie R. Walker, Jens Bukh, Lisa Maher, Tom Gordon, Miles P. Davenport, Fabio Luciani, Heidi E. Drummer, Andrew R. Lloyd, Rowena A. Bull
Journal: Journal of Hepatology (2024)

In individuals highly exposed to HCV, reinfection is common, suggesting that natural development of sterilising immunity is difficult. In those that are reinfected, some will develop a persistent infection, while a small proportion repeatedly clear the virus, suggesting natural protection is possible. The aim of this study was to characterise immune responses associated with rapid natural clearance of HCV reinfection.
Head-to-toe bedside ultrasound for adult patients on extracorporeal membrane oxygenation
Authors: Ghislaine Douflé, Laura Dragoi, Diana Morales Castro, Kei Sato, Dirk W. Donker, Nadia Aissaoui, Eddy Fan, Hannah Schaubroeck, Susanna Price, John F. Fraser, Alain Combes
Journal: Intensive Care Medicine (2024)
<i>Lactococcus lactis HkyuLL 10</i> suppresses colorectal tumourigenesis and restores gut microbiota through its generated alpha-mannosidase
Authors: Anthony Chin Yang Su, Xiao Ding, Harry Cheuk Hay Lau, Xing Kang, Qing Li, Xueliang Wang, Yali Liu, Lanping Jiang, Yinghong Lu, Weixin Liu, Yanqiang Ding, Alvin Ho-Kwan Cheung, Ka Fai To, Jun Yu
Journal: Gut (2024)

Objective Probiotic Lactococcus lactis is known to confer health benefits to humans. Here, we aimed to investigate the role of L. lactis in colorectal cancer (CRC). Design L. lactis abundance was evaluated in patients with CRC (n=489) and healthy individuals (n=536). L. lactis was isolated from healthy human stools with verification by whole genome sequencing. The effect of L. lactis on CRC tumourigenesis was assessed in transgenic Apc Min/+ mice and carcinogen-induced CRC mice. Faecal microbiota was profiled by metagenomic sequencing. Candidate proteins were characterised by nano liquid chromatography-mass spectrometry. Biological function of L. lactis conditioned medium ( HkyuLL 10 -CM) and functional protein was studied in human CRC cells, patient-derived organoids and xenograft mice. Results Faecal L. lactis was depleted in patients with CRC. A new L. lactis strain was isolated from human stools and nomenclated as HkyuLL 10. HkyuLL 10 supplementation suppressed CRC tumourigenesis in Apc Min/+ mice, and this tumour-suppressing effect was confirmed in mice with carcinogen-induced CRC. Microbiota profiling revealed probiotic enrichment including Lactobacillus johnsonii in HkyuLL 10 -treated mice. HkyuLL 10 -CM significantly abrogated the growth of human CRC cells and patient-derived organoids. Such protective effect was attributed to HkyuLL 10 -secreted proteins, and we identified that α-mannosidase was the functional protein. The antitumourigenic effect of α-mannosidase was demonstrated in human CRC cells and organoids, and its supplementation significantly reduced tumour growth in xenograft mice. Conclusion HkyuLL 10 suppresses CRC tumourigenesis in mice through restoring gut microbiota and secreting functional protein α-mannosidase. HkyuLL 10 administration may serve as a prophylactic measure against CRC.
Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction
Authors: Tianpeng Wang, Jingchen Shao, Shamit Kumar, Mohammad Wessam Alnouri, Jorge Carvalho, Stefan Günther, Cornelius Krasel, Kate T. Murphy, Moritz Bünemann, Stefan Offermanns, Nina Wettschureck
Journal: Circulation Research (2024)

GPCRs (G-protein-coupled receptors) play a central role in the regulation of smooth muscle cell (SMC) contractility, but the function of SMC-expressed orphan GPCR class C group 5 member C (GPRC5C) is unclear. The aim of this project is to define the role of GPRC5C in SMC in vitro and in vivo.
A commentary on “assessment of treatment outcomes: cytoreductive surgery compared to radiotherapy in oligometastatic prostate cancer - an in-depth quantitative evaluation and retrospective cohort analysis”
Authors: Jiacheng Chen, Jincai Wu, Haijing Yu
Journal: International Journal of Surgery (2024)

aDepartment of Hepatobiliary & Pancreatic Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan Province, 570311, China bDepartment of International Nursing School, Hainan Medical University, Haikou, Hainan Province, 570102, China Co-first authorship: Jiacheng Chen and Jincai Wu Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of International Nursing School, Hainan Medical University, Haikou, Hainan Province, 570102, China. Email: [email protected] (H. Yu). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
An Electron Donor–Acceptor Structured Rhenium(I) Complex Photo‐Sensitizer Evokes Mutually Reinforcing "Closed‐Loop" Ferroptosis and Immunotherapy
Authors: Qingyan Ren, Haobing Wang, Dan Li, Anyi Dao, Jiajun Luo, Deliang Wang, Pingyu Zhang, Huaiyi Huang
Journal: Advanced Healthcare Materials (2024)

The hypoxic microenvironment of solid tumors severely lowers the efficacy of oxygen-dependent photodynamic therapy (PDT). The development of hypoxia-tolerant photosensitizers for PDT is an urgent requirement. In this study, a novel rhenium complex (Re-TTPY) to develop a "closed-loop" therapy based on PDT-induced ferroptosis and immune therapy is reported. Due to its electron donor-acceptor (D-A) structure, Re-TTPY undergoes energy transfer and electron transfer processes under 550 nm light irradiation and displays hypoxia-tolerant type I/II combined PDT capability, which can generate
One-year results of the flowdynamics dense mesh stent for residual dissection after proximal repair of stanford type a or type b aortic dissection: a multicenter, prospective and randomized study
Authors: Chen Lu, Weixun Duan, Zhen Li, Chenhao Wang, Peng Yang, Yu Liu, Jian Zuo, Jia Hu
Journal: International Journal of Surgery (2024)

Objective: Negative remodeling of the distal aorta following proximal repair for acute aortic dissection has garnered growing attention. This clinical scenario has spurred the development of techniques and devices. A multicenter, prospective, and randomized controlled study was conducted with the aim of confirming the safety and effectiveness of a newly-designed flowdynamics dense mesh stent for the treatment of residual dissection after proximal repair. Methods: Patients with nonchronic residual dissection affecting visceral branches were prospectively enrolled at three centers and randomly allocated to either the FDMS group or the control group. Primary endpoints encompassed all-cause and aortic-related mortality, while the patency of branch arteries is indeed a key focal metric. Morphological changes (diameter, area, and volume) were analyzed to demonstrate the therapeutic effect. Results: 112 patients were recruited in the clinical trial, and 103 patients completed the 12-month follow-up. The rate of freedom from all-cause and aortic-related death in the FDMS group was 94.64% and 100%, respectively. All visceral branches remained patent. The FDMS group exhibited a substantial expansion in TL and a notable shrinkage in FL at the planes below renal arteries (ΔArea TL : FDMS vs. Control, 0.74±0.46 vs. 0.34±0.66 cm 2 , P &lt;0.001; ΔArea FL : FDMS vs. Control, -0.72±1.26 vs. -0.12±0.86 cm, P = 0.01) and 5 cm below renal arteries (ΔArea TL : FDMS vs. Control, 1.06±0.75 vs. 0.16±0.63 cm 2 , P &lt;0.001; ΔArea FL : FDMS vs. Control, -0.53±1.43 vs. -0.25±1.00 cm, P = 0.27). Meanwhile, the FDMS group demonstrated an increase of 22.55±11.14 cm 3 in TL ( P &lt;0.001) and a corresponding reduction of 21.94±11.77 cm 3 in FL ( P =0.08). Conclusions: This newly-designed FDMS for endovascular repair of residual dissection following the proximal repair is demonstrated to be safe and effective at 12 months.
A commentary on “ Impact of virtual reality education on disease-specific knowledge and anxiety for hepatocellular carcinoma patient scheduled for liver resection: a randomized controlled study”
Authors: Guangwei Qing, Guang Yang
Journal: International Journal of Surgery (2024)

aJiangxi Mental Hospital & Affiliated Mental Hospital of Nanchang University, Third Clinical Medical College of Nanchang University, Nanchang, Jiangxi 330029, China bDepartment of Neurology, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu 215399, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Neurology, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu 215399, China. E-mail address: [email protected] (G. Yang). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
A commentary on “Current perspectives and trend of Computer-Aided drug design: a review and bibliometric analysis”
Authors: Jing Jiang, Yun Ye, Fangxian Li, Hedan Luo, Wenbo Wang
Journal: International Journal of Surgery (2024)

Jiang, Jing MB; Ye, Yun MM; Li, Fangxian; Luo, Hedan MB; Wang, Wenbo MB Author Information
Thermal ablation with and without adjuvant systemic therapy: a nationwide multicenter observational cohort study of solitary colorectal liver metastases
Authors: Jianming Li, Chuan Pang, Guangjian Liu, Xiaoyan Xie, De-zhi Zhang, Kai Li, Zhishuai Li, Guangbin He, Erjiao Xu, Huage Zhong, Hong Yang, Man Lu, Kexin Lou, Xiang Xie, Sirong Lan, Qian Li, Guanghai Dai, Jie Yu, Ping Liang
Journal: International Journal of Surgery (2024)

Background: Thermal ablation is routinely used for solitary colorectal liver metastases (SCLM), but the added value of adjuvant systemic therapy in SCLM remains unclear. This study aimed to compare the long-term outcomes for SCLM treated by ablation alone (AB) versus ablation plus systemic therapy (AS). Methods: This multicenter retrospective study using nationwide data from fourteen institutions between October 2010 and May 2023, 369 patients with initial SCLM smaller than 5 cm, no extrahepatic metastases, and colorectal cancer R0 resection treated by thermal ablation were included. The crude analysis was used to analyze eligible cases between the two groups. The propensity score matching (PSM) to control for potential confounders in each matched group. Subgroup analyses were performed to identify specific survival benefits. Results: 61.2% (226/369) of eligible patients were treated with AS and 38.8% (143/369) with AB. During the median follow-up period of 8.8 years, 1-/3-/5-year DFS/OS rates did not differ between the two groups, when analyzed via PSM ( P =0.52/0.08). Subgroup analysis revealed that AS was significantly associated with better OS than AB in patients with plasma CEA &gt;5 ug/L ( P =0.036), T (III-IV) category of primary cancer ( P =0.034), or clinical risk score (1-2) ( P =0.041). In each matched group, we did find a significant difference in drug-related adverse events ( P &lt;0.001) between AS group (24.1%, 28/116) and AB group (0.0%, 0/116). Conclusions: For patients with plasma CEA &gt;5 ug/L, T (III-IV) category of primary cancer, or clinical risk score (1-2), thermal ablation plus systemic therapy appeared to be associated with improved overall survival. Thermal ablation was equally effective in disease-free survival for treating solitary colorectal liver metastasis, whether with or without adjuvant systemic therapy.
Reply to “ comment on ‘efficacy of electroacupuncture in improving postoperative ileus in patients receiving colorectal surgery: A systematic review and meta-analysis’“
Authors: Kuo-Chuan Hung, Chia-Li Kao, Hsiao-Tien Chen, I-Wen Chen
Journal: International Journal of Surgery (2024)

Hung, Kuo-Chuan MD; Kao, Chia-Li BSc; Chen, Hsiao-Tien MD; Chen, I-Wen MD Author Information
A commentary on “complex causal association between genetically predicted 731 immunocyte phenotype and osteonecrosis: a bidirectional two-sample mendelian randomization analysis”
Authors: Yilong Lin, Ruidan Zhao, Qingmo Yang
Journal: International Journal of Surgery (2024)

Department of Breast Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361003, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Breast Surgery, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Siming District, Xiamen, Fujian 361003, China. E-mail address: [email protected] (Q. Yang,). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
A commentary on ‘Pulmonary vagus nerve transection for chronic cough after video-assisted lobectomy: A randomized controlled trial’
Authors: Ze-Gang Ruan, Chen-Yang Xu, Lan-Fang Hua
Journal: International Journal of Surgery (2024)

Department of Thoracic Surgery, Ganzhou People's Hospital, Jiangxi Medical College, Nanchang University, Ganzhou, Jiangxi, People's Republic of China. Ze-Gang Ruan and Chen-Yang Xu share co-first authorship. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Thoracic Surgery, Ganzhou People's Hospital, Jiangxi Medical College, Nanchang University, Ganzhou 341000, Jiangxi, People's Republic of China. Tel.:+86 13767752686. E-mail address: [email protected] (L.-F. Hua). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
The Utility of Prostate-Specific Membrane Antigen-11 PET in Detection and Management of Central Nervous System Neoplasms
Authors: Mina Dawod, Evan Rush, Paul B. Nagib, Jessica Aduwo, Pranav Bodempudi, Emmanuel Appiah-Kubi
Journal: Clinical Nuclear Medicine (2024)

Abstract We present a case series of 5 patients diagnosed with schwannoma and 1 patient diagnosed with astrocytoma who underwent PSMA PET imaging for tumor detection. We retrospectively analyzed the records of 4 male and 2 female patients (mean age, 53.2 ± 13.2) who underwent PSMA PET imaging between March and September 2023. PET interpretation showed increased Ga-PSMA-11 accumulation in all patients with a mean SUV max of 3.11 ± 1.8. This series underscores PSMA PET’s potential for CNS neoplasm detection.
Radioiodine Uptake at Suture Site Granuloma Mimicking Neck Node Metastasis on 131I Whole-Body Iodine Scintigraphy
Authors: Parneet Singh, Kanhaiyalal Agrawal, Ranjan Kumar Patel, P. Sai Sradha Patro, Girish Kumar Parida
Journal: Clinical Nuclear Medicine (2024)

Abstract Differentiated thyroid carcinoma constitutes over 90% of all thyroid cancers. The standard treatment approach involves total or near-total thyroidectomy with or without neck dissection followed by 131 I whole-body scintigraphy (WBS) to detect local or distant metastases. Radioiodine offers high sensitivity and specificity for detection of metastatic disease in well differentiated thyroid carcinoma. However, despite its high accuracy, 131 I WBS demonstrates false-positive results, mostly at inflammatory or infective site. These false-positive radioiodine accumulation can lead to misdiagnosis and unwarranted radioiodine treatment. This case presents localization of 131 I to the suture site granuloma leading to false-positive results on 131 I WBS.
Intense FDG Uptake in Well-Differentiated Inflammatory Liposarcoma of the Retroperitoneum
Authors: Qian Zhao, Aisheng Dong, Changjing Zuo, Yu Fang
Journal: Clinical Nuclear Medicine (2024)

Inflammatory variant of well-differentiated liposarcoma is a rare subtype of liposarcoma, and its imaging features have been rarely reported. We describe FDG PET/CT findings in a case of well-differentiated inflammatory liposarcoma. The tumor showed no detectable fat and intense FDG uptake and caused diffuse FDG uptake of the bone marrow due to paraneoplastic leukemoid reaction. Microscopically, there were extensive inflammatory infiltrates in the tumor, which may contribute to the intense FDG uptake. This case indicates that although well-differentiated liposarcoma usually shows low-grade FDG uptake, inflammatory variant of well-differentiated liposarcoma can show intense FDG uptake mimicking high-grade liposarcoma.