tbuckley/cabot-search huggingface dataset:
Atlas of Synovial Fluid Analysis and Crystal Identification
Authors: H. Ralph Schumacher, Antonio J. Reginato
Journal: Annals of Internal Medicine (1991)

Synovial fluid analysis gross appearance and viscosity leukocyte count and differential wet preparations stained preparations crystal identification monosodium urate crystals calcium pyrophosphate dihydrate crystals apatite crystals and other calcium phosphates calcium oxalate crystals crystalline and noncrystalline lipids synthetic depot corticosteroid crystals charcot-leyden crystals immunoglobin crystals hemoglobin and hematoidin crystals unusual crystals found in muscle and bone foreign bodies artifacts and unexplained birefringent particles on wet preparations appendix.
Abstract 1473: Identification Of A New NRSF-binding Partner, Zfp90, Which Negatively Regulates The Repression Activity Of NRSF, A Critical Transcriptional Regulator Of Cardiac Fetal Gene Program
Authors: Masao Murakami, Koichiro Kuwahara, Masaki Harada, Yasuaki Nakagawa, Satoru Usami, Hideyuki Kinoshita, Shinji Yasuno, Masataka Fujiwara, Kenji Ueshima, Kazuwa Nakao
Journal: Circulation (2008)

Neuron-restrictive silencer factor, NRSF is a Zn-finger transcription factor that specifically binds to DNA sequence called NRSE to repress the transcription. NRSF is involved in various biological processes, such as neuronal differentiation, carcinogenesis, and cardiac homeostasis. We previously reported that NRSF regulates the transcription of multiple fetal cardiac genes. Cardiac-specific overexpression of a dominant-negative form of NRSF in mice induced reactivation of fetal cardiac gene program, cardiac dysfunction, and sudden arrhythmic death, suggesting NRSF plays important roles in normal cardiac homeostasis. However, the molecular mechanisms or signaling pathways that regulate the activity of NRSF have not been well understood. In an attempt to clarify the regulators of NRSF, we performed yeast two-hybrid screening using NRSF as bait and identified Zfp90 as NRSF-binding protein. NRSF and Zfp90 co-localize in the nuclear, and Zn-finger domain of NRSF specifically interacted with KRAB domain of Zfp90. To monitor the activity of NRSF sensitively, we made NRSF-responsive reporters using NRSE sequence of BNP promoter and established assay system for estimating the NRSF activity. In this assay system, expression of NRSF repressed the reporter activity and co-expression of Zfp90 restored it. Furthermore the expression levels of Zfp90 were elevated in the hearts with cardiomyopathy. These results suggest that Zfp90 functions as a negative regulator of NRSF and contributes to the genetic remodeling during the development of cardiomyopathy..
Long-term follow-up of high-dose treatment (HDT) with autologous haematopoietic progenitor cell support in 702 patients (pts.) with follicular lymphoma (FL). An EBMT registry study
Authors: S. Montoto, A. Z. Rohatiner, C. Canals, C. Gisselbrecht, L. Fouillard, N. Milpied, C. Haioun, G. Taghipour, N. Schmitz, A. H. Goldstone
Journal: Journal of Clinical Oncology (2006)

7526 Background: HDT with stem cell rescue has been increasingly used in pts. with FL. The aim of this retrospective analysis was to evaluate the outcome of a large series of pts. who received HDT for FL. Patients: From 1979 to 1995, 702 pts. (median age: 45, range: 17–68 yrs.) underwent HDT with a TBI-containing regimen in 407 cases and chemotherapy-based regimens in 276 (BEAM, 164). The median time from diagnosis to HDT was 2.2 yrs. Disease status at the time of HDT was as follows: CR, 323 pts. (1st: 138; 2nd: 141; 3rd: 44); PR, 170 pts.; recurrence/progression, 187 pts. (“sensitive”, 152; resistant, 20; untested, 15); primary refractory, 22 pts. The source of progenitor cells was bone marrow (BM) in 384 pts. (55%), peripheral blood progenitor cells (PBPC) in 288 (41%) and BM + PBPC in 30 (4%). Results: 353/702 pts. (50%) developed recurrent lymphoma at a median of 1.7 yrs. (range: 0.2 to 13.3) after HDT. 5-year PFS after HDT was 43%. On multivariate analysis, age at HDT &lt;45 yrs. and HDT in CR1 correlated with longer PFS; refractory disease was the only variable predictive for risk of recurrence. 23 pts. developed secondary MDS/AML, in 18 cases after receiving TBI. With a median follow-up of 10.2 yrs., 338 patients have died, 96 without lymphoma progression. The 5-year non-relapse mortality (NRM) was 9%. On multivariate analysis, age &gt; 45 at HDT, refractory disease at HDT and TBI were associated with a higher NRM. 5-yr and 10-yr OS from HDT were 64% and 52%, respectively. For pts. treated with HDT in CR1, 10-yr OS and PFS from HDT were 71% and 46%, respectively. The variables that predicted for a longer OS in the multivariate analysis were younger age at HDT, CR1 at HDT and the use of a non TBI-containing regimen. The effect of TBI on NRM and OS was mostly as a consequence of late mortality. Conclusions: This analysis confirms that the best outcome was associated with younger age and treatment in CR1. In addition, in this study TBI was associated with a negative impact on survival. No significant financial relationships to disclose.
ALCOHOL AND FATAL ACCIDENTS: NATIONAL ESTIMATES - USA
Authors: D M Gragg
Journal: New England Journal of Medicine (1982)

Detailed statistics are presented on the presence and level of alcohol in drivers and pedestrians involved in fatal motor vehicle accidents. The results of this study highlight the number and percentage of drivers and pedestrians that fall into each of six established blood alcohol concentration (BAC) level categories. These categories cover the entire spectrum of BAC values, which range from 0 to greater than 0,20. Estimates are provided by sex and age groups of drivers and for each of the four distinct types of fatal accidents: (1) hit and run; (2) pedestrian; (3) single vehicle; and (4) multivehicle. Data are utilized from 29 selected states, and use is made of the police indication of alcohol presence in the driver. (Author/TRRL)
Deconstructing the process of change in cognitive behavioral therapy: An alternative approach focusing on the episodic retrieval mode
Authors: Angelica Staniloiu, Ari E. Zaretsky
Journal: Behavioral and Brain Sciences (2015)

Abstract Lane et al. view the process of memory reconsolidation as a main ingredient of psychotherapeutic change. They ascertain that in cognitive behavioral therapy (CBT) high priority is given to the “semantic structure.” We argue that memory-related mechanisms of change in CBT are more nuanced than the target article presents. Furthermore, we propose to partially shift the focus from the process of reconsolidation to the retrieval operations.
Clemens von Pirquet: His Life and Work
Authors: Richard Wagner
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vascular endothelial growth factor (VEGF) polymorphism is associated with prognosis of patients with gastric cancer
Authors: Y. Chae, J. Kim, J. Baek, E. Cho, S. Sohn, H. Chung, W. Yu, M. Lee, H. Bae
Journal: Journal of Clinical Oncology (2006)

4019 Background: Recent studies demonstrated that the expression of vascular endothelial growth factor (VEGF) family had a prognostic significance in patients with gastric cancer. The present study analyzed VEGF polymorphism and its impact on prognosis in patients with gastric cancer. Methods: Five hundred three consecutive patients with surgically resected gastric adenocarcinoma at a single institution between January 2000 and December 2001 were enrolled into the study. Genomic DNA was extracted from paraffin-embedded tumor tissue and four VEGF (-460T &gt; C, +405C &gt; G, 936C&gt; T, and -1154G &gt; A) genotypes were determined using a PCR-RFLP assay. Results: The median age of patients was 60.0 years (range, 25–83 years), and 337 (67.0%) patients were male. Pathologic stages after resection were as follows: stage 0 (n=6, 1.2%), stage I (n=277, 55.1%), stage II (n=105, 20.9%), stage III (n=74, 14.7%), and stage IV (n=41, 8.2%). The estimated 5-year disease-free survival (DFS) rates according to stage were significantly different (p &lt; 0.0001). Three VEGF polymorphisms (+405C &gt; G, 936C, and -1154G &gt; A &gt; T) were not associated with survival of patients, while -460T &gt; C polymorphism had a prognostic significance. In patients with early stage gastric cancer (stage 0 or 1, n=283), the estimated 5-year DFS and carcinoma-specific survival (CSS) for patients with homozygous genotype (CC or TT) of -460T &gt; C were superior to those for heterozygous genotype (CT) (98.1% versus 90.3%, p=0.0047; 98.1% versus 92.5%, p=0.0284). In Cox multivariate regression, stage and VEGF -460T &gt; C genotype were an independent prognostic factors for both DFS (p=0.007; p=0.010) and CSS (p=0.013; p=0.038). Conclusions: VEGF -460T &gt; C polymorphism was found to be an independent prognostic marker for patients with curatively resected early stage gastric adenocarcinoma. Accordingly, VEGF -460T &gt; C polymorphism can help to identify patients with unfavorable clinical outcome and thereby may be useful to refine therapeutic decisions in early stage gastric cancer. No significant financial relationships to disclose.
Dual esophageal and colon self-expanding metal stenting for colon cancer arising in esophageal interposition
Authors: Paul Kröner, Klaus Mönkemüller
Journal: Endoscopy (2015)

A 67-year-old man was referred for high-grade stenosis of the esophagus and metastatic adenocarcinoma. His relevant medical history included esophageal metastatic adenocarcinoma resected 10 years previously, for which he had undergone colonic interposition and chemotherapy. His risk factors included smoking one pack of cigarettes/day for over 20 years and consuming 2 ounces of alcohol/day for 30 years. He complained of progressive dysphagia to solids that had started 2 days before referral. An upper gastrointestinal series had been performed, which had been reported as a presumably malignant, high-grade stenosis of the distal esophagus adjacent to the esophagogastric junction, and he was therefore referred to our center.
Abstract 2236: Three Gram Sodium Intake is Associated with Better Event-Free Survival Only in Patients with Advanced Heart Failure
Authors: Terry A Lennie, Misook L Chung, Seongkum Heo, Rebecca L Dekker, Debra K Moser
Journal: Circulation (2007)

Background: There is no consensus among published guidelines regarding the recommended level of sodium intake for patients with heart failure (HF), primarily related to a lack of research demonstra...
Diabetes black spots and death by postcode
Authors: G. Williams
Journal: BMJ (2001)

Papers p 1389 

Like the villain in Treasure Island , diabetes is well known for handing the “black spot” of early demise to its victims. This reputation will be enhanced by a study in this week's BMJ from South Tees, one of the United Kingdom's black spots for both poverty and premature death, mainly from cardiovascular disease. Roper et al present a depressing snapshot of the prospects for diabetic people in the UK today, which shows diabetes to be particularly mean: sexist, ageist, and with a clear tendency to kick the underdog (p 1389).1

Of their 4800 diabetic subjects, a quarter died during the study's six year span—an overall mortality about 2.2 times the national average. Those who developed diabetes youngest had their lives shortened the most: life expectancy was reduced by nine years for those diagnosed by the age of 40 but by only one year for those diagnosed at 80. Women diagnosed between 55 and 65 years of age lost two more years of life than did men. Finally, mortality tracked closely with socioeconomic deprivation, rising steadily from 1.3 times the national average in …
In Memoriam: Jean Lindenmann (1924-2015)
Authors: Olaf Stüve
Journal: JAMA Neurology (2015)

ometimes, the intended consequences of scientific discovery are not the ones that ultimately have the greatest impact on humanity.This is certainly the case of the interferons, which were discovered jointly by Jean Lindenmann and Alick Isaacs in an attempt to elucidate the role of interferons in host innate immune responses against viral infections.Dr Lindenmann, a Swiss virologist who passed away on January 15, 2015, in Zürich, Switzerland, was an outstanding scientist whose contributions to the interferon field were groundbreaking.
Pain Syndromes in Neurology
Authors: Howard L. Fields
Journal: Annals of Internal Medicine (1991)

Hiperalgesia and sensitization of primary afferent fibers, Srinivasa N.Raja, Richard A.Meyer and James N.Campbell pain and the pathophysiology of damaged nerve, Marshall Devor and Z.Harry Rappaport sympathetic nervous system influence on acute and chronic pain, William J.Roberts and Ronald C.Kramis reflex sympathetic dystrophy syndrome - diagnosis and treatment, Richard Payne pain in generalized neuropathies, Arthur K.Asbury management of nociceptive, deafferentation and central pain by surgical intervention, Ronald R. Tasker deafferentation on syndromes and dorsal root entry zone lesions, Burchiel postherpetic neurologica - clinical features and treatment, C.P.Watson diagnosis of cancer pain syndromes, Russel K.Portenoy pharmacologic management of chronic pain, Russel K. Portenoy.
Abstract 3761: A Monoclonal Antibody that Targets a Novel Site on the {beta}3 Subunit of the {alpha}V{beta}3 Integrin Blocks Lesion Development in a Porcine Model of Diabetes Accelerated Atherosclerosis
Authors: Laura A Maile, Walker H Busby, Timothy Nichols, Dwight Bellinger, Elizabeth P Merricks, Michael Rowlands, Umadevi Veluvolu, David R Clemmons
Journal: Circulation (2008)

Smooth muscle cells (SMC) grown in high glucose are more responsive to IGF-I than those grown in normal glucose, suggesting that enhancement of IGF-I actions may contribute to accelerated lesion de...
Hygiene of Communicable Diseases. A Handbook for Sanitarians, Medical Officers of the Army and Navy, and General Practitioners.
Authors: Francis Merton Munson
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12111: Adrenergic Receptor Genotype is Associated with Ventricular Dysfunction and {beta}-Blocker Response in Children with Dilated Cardiomyopathy
Authors: Alan Fung, Cedric Manlhiot, Seda Tierney, Sushma Reddy, Wendy Chung, Elizabeth Blume, Beth Kaufman, Elizabeth Goldmuntz, Steven Colan, Seema Mital
Journal: Circulation (2011)

Adrenergic receptor (ADR) genotype predicts response to β-blocker (BB) therapy in adult heart failure (HF). We investigated if ADR genotypes are associated with ventricular function and BB response...
The effect of mechanical heat recovery ventilation on the control of asthma: a randomised controlled trial
Authors: G.R. Wright, S.G. Howieson, C. McSharry, A.D. McMahon, R. Chaudhuri, J. Thompson, I. Fraser, L. Mcalpine
Journal: Thorax (2007)

Sensitivity to the house dust mite allergen Dermatophagoides pteronyssinus 1(Der p1) is commonly associated with asthma in the UK. The warm, humid environment of modern homes favours the house dust mite population. This study investigated the effect of improved domestic ventilation on the control of asthma.
Abstract 1867: Real-Time Three-Dimensional Echocardiographic Left Ventricular Mass to Volume Ratio Is Superior To Volumetric Indices For Arrhythmic Risk Prediction
Authors: Ebere O Chukwu, Rena S Toole, Jeanette Mclaughlin, Joseph H Levine, Steven Greenberg, David Hoch, Stuart O Schecter, Vinod Jayam, Nathaniel Reichek, Aasha Gopal
Journal: Circulation (2007)

Background: Left ventricular (LV) mass is an important prognostic factor for predicting cardiac morbidity and mortality. LV mass to volume ratio (M/V) by CMR has been shown to relate to adverse outcomes in several settings. However, the relevance of this M/V has not been established for post-MI arrhythmias. We evaluated the use of 3D echo (3D) LV M/V in predicting event free survival in post-MI patients meeting the MADIT II criteria, and compared it to EDV and ESV indexed to the body surface area (EDVi, ESVi). Methods: Forty patients (35 males, mean age 69.6y) meeting the MADIT II criteria for implantable defibrillator (ICD) placement with an EF of ≤30% were imaged and followed up for a mean of 472 days for adverse events (ventricular fibrillation or sustained ventricular tachycardia, and appropriate ICD discharges). Patients had 3D within 24 hours of ICD implantation. EDVi, ESVi and LV mass were determined and M/V calculated. Receiver operator curves (ROC) were used to determine the associations between M/V, EDVi, ESVi and adverse events. Results : Mean indexed LV mass was 109.7 g. Mean EDVi, ESVi were 123.3 ml/m 2 and 93.4ml/m 2 . The adverse event rate was 25% (10/40 patients). ROC curve analysis showed that M/V was significantly associated with adverse events(p = 0.002) while EDVi (p=0.12) and ESVi (p=0.08) were not. Patients with higher M/V were more likely to have events than those with smaller M/V (area under the curve = 0.74, sensitivity 80%, specificity 67%). Conclusion: 3D derived LV M/V is useful for determining risk of adverse events in high-risk post-MI patients who meet the MADIT II criteria. M/V is superior to 3D EDV, ESV for prediction of arrhythmic events this high risk population.
Male breast cancer: An analysis of clinical features, disease outcome and treatment efficacy
Authors: A. Deptala, I. Cedrych, A. Polakiewicz-Gilowska, E. Nowara, I. Domin
Journal: Journal of Clinical Oncology (2008)

11539 Background: Male breast cancer (MBC) accounts for about 1% of all cases of breast cancer. This scarcity explains the difficulty in assessing clinical features and evolution of management over time. Methods: A retrospective chart analysis of MBC, diagnosed and treated between 1976 and 2006 in two cancer departments in Poland, has been performed. This evaluation included 25 MBC patients (pts) with a median age at diagnosis of 60 (range 42–74). Median delay to diagnosis was 19 months (range 3–84). All the patients had pathology-confirmed invasive ductal adenocarcinoma of the breast. The most frequent G-score (according to Bloom-Richardson Grading System) was G2 and was detected in 12/25 pts (48%). The ER and/or PR positive status was confirmed in half of the patients (13/25) (52%). HER2 status was assessed only in 5 cases with HER2-overexpression in 2 of them. Results: Stage IV was diagnosed in 2 pts, stage III in 16 pts, stage IIB in 6 and stage I in 1. More then half of stage III pts had T4 tumor feature at presentation. Radical mastectomy undergone 19 pts (76%), and in 4 cases lumpectomy was performed. Chemotherapy received 16/25 pts (64%): 10 pts (40%) as induction/neoadjuvant, adjuvant 4 pts (16%), and palliative 2 (8%). CMF regimen was used in 12/16 pts (75%) and anthracycline-based chemotherapy received 4/16 pts (25%). Hormone therapy was applied to 13/25 pts (52%), usually tamoxifen; only 1 patient received anastrozole. Two pts with metastatic disease were treated with trastuzumab-based therapy. Radical breast irradiation (50 Gy) was performed in 16/25 cases (64%), 2 patients received palliative breast radiotherapy. Clinical overall response rate reached 86%. Survival analysis was performed using Kaplan-Meier survival curves. Overall 5-year and estimated 10-year survival were 66% and 35%, respectively. After the median follow-up of 51 months (range 12–162) 13 patients died, most of them due to MBC progression. Conclusions: MBC is a very rare disease comparing to female breast cancer, and therefore its rarity can be the major reason for a diagnostics and treatment delay. Despite growing awareness of this disease over time, MBC is still detected in more advanced stages than in women, which results poor clinical outcome. The optimal management of this entity needs to be defined. No significant financial relationships to disclose.
Enhancing Stem Cell Therapy Through Genetic Modification**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Victor J. Dzau, Massimiliano Gnecchi, Alok S. Pachori
Journal: Journal of the American College of Cardiology (2005)
Abstract 9342: Risk Stratification in a Diabetic Population With Metabolic Syndrome Using Coronary Calcium Scores: Diabetes Heart Study
Authors: Subhashish Agarwal, Timothy Morgan, David Herrington, Jianzhao Xu, Barry I Freedman, John J Carr, Donald W Bowden
Journal: Circulation (2010)

Introduction: Patients with diabetes and metabolic syndrome (MetS) have increased all cause mortality, in part due to increased cardiovascular disease. In this high risk group it remains unclear wh...