tbuckley/cabot-search huggingface dataset:
Mimicomes: Mimicking Multienzyme System by Artificial Design
Authors: Haolin Cao, Jing Jiang, Lei Chen, Lizeng Gao
Journal: Advanced Healthcare Materials (2024)

Enzymes are widely distributed in organelles of cells, which are capable of carrying out specific catalytic reactions. In general, several enzymes collaborate to facilitate complex reactions and engage in vital biochemical processes within cells, which are also called cascade systems. The cascade systems are highly efficient, and their dysfunction is associated with a multitude of endogenous diseases. The advent of nanotechnology makes it possible to mimic these cascade systems in nature and realize partial functions of natural biological processes both in vitro and in vivo. To emphasize the significance of artificial cascade systems, mimicomes is first proposed, a new concept that refers to the artificial cascade catalytic systems. Typically, mimicomes are able to mimic specific natural biochemical catalytic processes or facilitate the overall catalytic efficiency of cascade systems. Subsequently, the evolution and development of different types of mimicomes in recent decades are elucidated exhaustedly, from the natural enzyme-based mimicomes (immobilized enzyme and vesicle mimicomes) to the nanozyme-based mimicomes and enzyme-nanozyme hybrid mimicomes. In conclusion, the remaining challenges in the design of multifunctional mimicomes and their potential applications are summarized, offering insights into their future prospects.
Motor‐Cargo Structured Nanotractors for Augmented NIR Phototherapy via Gas‐Boosted Tumor Penetration and Respiration‐Impaired Mitochondrial Dysfunction
Authors: Jing Wang, Yi Zhang, Huadong Chen, Yihan Wu, Jinliang Liu, Hailong Che, Yong Zhang, Xiaohui Zhu
Journal: Advanced Healthcare Materials (2024)

Tumor microenvironment, characterized by dense extracellular matrix and severe hypoxia, has caused pronounced resistance to photodynamic therapy (PDT). Herein, it has designed an artificial nitric oxide (NO) nanotractor with a unique "motor-cargo" structure, where a photoswitching upconversion nanoparticle (UCNP) core serves as the optical engine to harvest NIR light and asymmetrically coated mesoporous silica (SiO
Association of Cannabis Use Reduction With Improved Functional Outcomes: An Exploratory Aggregated Analysis From Seven Cannabis Use Disorder Treatment Trials to Extract Data-Driven Cannabis Reduction Metrics
Authors: Erin A. McClure, Brian Neelon, Rachel L. Tomko, Kevin M. Gray, Aimee L. McRae-Clark, Nathaniel L. Baker
Journal: American Journal of Psychiatry (2024)

This exploratory analysis sought to determine whether decreases in cannabis use are associated with improvements in cannabis-related problems and functional outcomes, and if so, what percentage decrease is associated with improvement.
DEK regulates B-cell proliferative capacity and is associated with aggressive disease in low-grade B-cell lymphomas
Authors: Melissa A. Hopper, Abigail R. Dropik, Janek S. Walker, Joseph P. Novak, Miranda S. Laverty, Michelle K. Manske, Xiaosheng Wu, Kerstin Wenzl, Jordan E. Krull, Vivekananda Sarangi, Matthew J. Maurer, Zhi-Zhang Yang, Miles D. Del Busso, Thomas M. Habermann, Brian K. Link, Lisa M. Rimsza, Thomas E. Witzig, Stephen M. Ansell, James R. Cerhan, Dragan Jevremovic, Anne J. Novak
Journal: Blood Cancer Journal (2024)

This study sheds light on the pivotal role of the oncoprotein DEK in B-cell lymphoma. We reveal DEK expression correlates with increased tumor proliferation and inferior overall survival in cases diagnosed with low-grade B-cell lymphoma (LGBCL). We also found significant correlation between DEK expression and copy number alterations in LGBCL tumors, highlighting a novel mechanism of LGBCL pathogenesis that warrants additional exploration. To interrogate the mechanistic role of DEK in B-cell lymphoma, we generated a DEK knockout cell line model, which demonstrated DEK depletion caused reduced proliferation and altered expression of key cell cycle and apoptosis-related proteins, including Bcl-2, Bcl-xL, and p53. Notably, DEK depleted cells showed increased sensitivity to apoptosis-inducing agents, including venetoclax and staurosporine, which underscores the therapeutic potential of targeting DEK in B-cell lymphomas. Overall, our study contributes to a better understanding of DEK's role as an oncoprotein in B-cell lymphomas, highlighting its potential as both a promising therapeutic target and a novel biomarker for aggressive LGBCL. Further research elucidating the molecular mechanisms underlying DEK-mediated tumorigenesis could pave the way for improved treatment strategies and better clinical outcomes for patients with B-cell lymphoma.
Phase II study of novel CXCR2 agonist and Plerixafor for rapid stem cell mobilization in patients with multiple myeloma
Authors: Surbhi Sidana, Andriyana K. Bankova, Hitomi Hosoya, Shaji K. Kumar, Tyson H. Holmes, John Tamaresis, Anne Le, Lori S. Muffly, Sofia Maysel-Auslender, Laura Johnston, Sally Arai, Robert Lowsky, Everett Meyer, Andrew Rezvani, Wen-Kai Weng, Matthew J. Frank, Parveen Shiraz, Holden T. Maecker, Ying Lu, David B. Miklos, Judith A. Shizuru
Journal: Blood Cancer Journal (2024)

MGTA-145 or GROβT, a CXCR2 agonist, has shown promising activity for hematopoietic stem cell (HSC) mobilization with plerixafor in pre-clinical studies and healthy volunteers. Twenty-five patients with multiple myeloma enrolled in a phase 2 trial evaluating MGTA-145 and plerixafor for HSC mobilization (NCT04552743). Plerixafor was given subcutaneously followed 2 h later by MGTA-145 (0.03 mg/kg) intravenously with same day apheresis. Mobilization/apheresis could be repeated for a second day in patients who collected <6 ×10
Differential Tfh cell phenotypes distinguish IgE-mediated milk allergy from eosinophilic esophagitis in children
Authors: Daniel Lozano-Ojalvo, Xin Chen, Wajiha Kazmi, David Menchén-Martínez, Leticia Pérez-Rodríguez, Weslley Fernandes-Braga, Scott Tyler, Keith Benkov, Nanci Pittman, Joanne Lai, Hugh A. Sampson, Maria Curotto de Lafaille, David Dunkin, M. Cecilia Berin
Journal: Journal of Allergy and Clinical Immunology (2024)
Real-world treatment outcomes of systemic treatments for moderate-to-severe atopic dermatitis in children aged less than 12 years: 2-year results from PEDISTAD
Authors: Amy S Paller, Marjolein de Bruin-Weller, Danielle Marcoux, Eulalia Baselga, Vania Oliveira de Carvalho, Ledit R F Ardusso, Suzanne G M A Pasmans, Mirna Toledo-Bahena, Cory Rubin, Joel C Joyce, Lara Wine Lee, Bryan Adams, Rajan Gupta, Marius Ardeleanu, Annie Zhang
Journal: Journal of the American Academy of Dermatology (2024)

The arrival of biologics and small-molecule therapies (eg Janus kinase inhibitors) changed atopic dermatitis treatment, but older systemic treatments continue to be prescribed.
Remote cutaneous confocal microscopy: A multicentric prospective study evaluating diagnostic accuracy for melanoma and keratinocyte carcinoma in tertiary settings
Authors: Genevieve Ho, Helena Collgros, Christoph Sinz, Bruna Melhoranse-Gouveia, Bruna Gallo, Christopher Y Chew, Ken Ip, James Koutsis, Serigne N Lo, Rodrigo Schwartz-Aldea, Hsien Herbert Chan, Peter Ferguson, Hannah Gribbin, Victoria Mar, Hans Peter Soyer, Linda K Martin, Andrea L Smith, Anne E Cust, Pascale Guitera
Journal: Journal of the American Academy of Dermatology (2024)
Thin and in situ melanomas of unfavorable prognosis: a retrospective observational analysis of local recurrence, metastasis, and death in early-stage disease
Authors: Joao Renato V. Gontijo, Jacob H. Nelson, Kyra Diehl, Veselina B. Korcheva, Flavia Vasques Bittencourt, Sancy A. Leachman
Journal: Journal of the American Academy of Dermatology (2024)
Mitochondrial-uncoupling nanomedicine for self-heating and immunometabolism regulation in cancer cells
Authors: Zhe Yang, Ying Zhou, Xiaozhen Liu, Liujiao Ren, Xinyang Liu, Rong Yun, Liangliang Jia, Xuechun Ren, Ying Wang, Yan Sun, Jia Li, Di Gao, Zhongmin Tian
Journal: Biomaterials (2024)
Pathologic Response of Phase III Study: Perioperative Camrelizumab Plus Rivoceranib and Chemotherapy Versus Chemotherapy for Locally Advanced Gastric Cancer (DRAGON IV/CAP 05)
Authors: Chen Li, Yantao Tian, Yanan Zheng, Fei Yuan, Zheng Shi, Lin Yang, Hao Chen, Lixin Jiang, Xixun Wang, Ping Zhao, Benyan Zhang, Zhenqiang Wang, Qun Zhao, Jianhong Dong, Changhong Lian, Sanrong Xu, Aimin Zhang, Zhichao Zheng, Kang Wang, Chengxue Dang, Dan Wu, Jian Chen, Yingwei Xue, Bo Liang, Xiangdong Cheng, Qian Wang, Luchuan Chen, Tao Xia, Heli Liu, Dazhi Xu, Jing Zhuang, Tao Wu, Xi Zhao, Wei Wu, Hongzhi Wang, Junsheng Peng, Zhiguo Hou, Rongrong Zheng, Yuting Chen, Kai Yin, Zhenggang Zhu
Journal: Journal of Clinical Oncology (2024)

This multicenter, randomized phase III trial evaluated the efficacy and safety of perioperative camrelizumab (an anti-PD-1 antibody) plus low-dose rivoceranib (a VEGFR-2 inhibitor) and S-1 and oxaliplatin (SOX) (SOXRC), high-dose rivoceranib plus SOX (SOXR), and SOX alone (SOX) for locally advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma.
Reply to P. de Boissieu et al
Authors: David R. Spigel, Afshin Dowlati, Yuanbin Chen, Alejandro Navarro, James Chih-Hsin Yang, Goran Stojanovic, Maria Jove, Patricia Rich, Zoran G. Andric, Yi-Long Wu, Charles M. Rudin, Huanyu Chen, Li Zhang, Stanley Yeung, Fawzi Benzaghou, Luis Paz-Ares, Paul A. Bunn
Journal: Journal of Clinical Oncology (2024)
Electrically-stimulated cellular and tissue events are coordinated through ion channel-mediated calcium influx and chromatin modifications across the cytosol-nucleus space
Authors: Shanika Karunasagara, Buuvee Bayarkhangai, Hye-Won Shim, Han-Jin Bae, Hwalim Lee, Ali Taghizadeh, Yunseong Ji, Nandin Mandakhbayar, Hye Sung Kim, Jeongeun Hyun, Tae-Jin Kim, Jung-Hwan Lee, Hae-Won Kim
Journal: Biomaterials (2024)
Further Optimizing Care of Patients With Operable Hormone Receptor–Sensitive Breast Cancer
Authors: Alexandra Thomas, Erica L. Mayer, Angela DeMichele, Nadia Harbeck, Giuseppe Curigliano, Michail Ignatiadis, Virginie Adam, Yang Zhou, Thelma P. Brown, Leslie Gilham, Boon H. Chua, Kevin Kalinsky, Antonio C. Wolff, Seamus O'Reilly
Journal: Journal of Clinical Oncology (2024)

Harmonized global collaborations are crucial to improving outcomes in hormone sensitive operable breast cancer.
Novel mobile colistin resistance gene mcr-4.9 in Vibrio cholerae from migratory birds
Authors: Weishuai Zhai, Hanzhang Cai, Dongyan Shao, Xiaojie Yu, Xiong Zhu, Dejun Liu, Zhangqi Shen, Shaolin Wang, Jijun Kang, Congming Wu, Jianzhong Shen, Yang Wang, Lu Liu
Journal: Drug Resistance Updates (2024)
Epidemiological comparison of emergency department presentations with seasonal influenza or COVID-19 and an outcome of intensive care admission or death: a population-based records linkage study in New South Wales, Australia
Authors: David J. Muscatello, Nectarios Rose, Kishor Kumar Paul, Sandra Ware, Michael M. Dinh, Mohammed Mohsin, Adam T. Craig, Amalie Dyda, Roberto Forero
Journal: Journal of Infection (2024)

COVID-19 and seasonal influenza are endemic causes of morbidity and mortality. This study aimed to compare the epidemiology of severe illness and risk of death among patients following emergency department (ED) presentation with either infection.
Central NUCB2/nesfatin-1 signaling ameliorates liver steatosis through suppression of endoplasmic reticulum stress in the hypothalamus
Authors: Yirui He, Cheng Zhang, Shaobo Wu, Ke Li, Siliang Zhang, Mingyuan Tian, Chen Chen, Dongfang Liu, Gangyi Yang, Ling Li, Mengliu Yang
Journal: Metabolism (2024)
Wastewater monitoring of human and avian influenza A viruses in Northern Ireland: a genomic surveillance study
Authors: Andrew J Lee, Stephen Carson, Marina I Reyne, Andrew Marshall, Daniel Moody, Danielle M Allen, Pearce Allingham, Ashley Levickas, Arthur Fitzgerald, Stephen H Bell, Jonathan Lock, Jonathon D Coey, Cormac McSparron, Behnam F Nejad, Evan P Troendle, David A Simpson, David G Courtney, Gisli G Einarsson, James P McKenna, Derek J Fairley, Tanya Curran, Jennifer M McKinley, Deirdre F Gilpin, Ken Lemon, John W McGrath, Connor G G Bamford
Journal: The Lancet Microbe (2024)

Influenza A viruses (IAVs) are significant pathogens of humans and other animals. Although endemic in humans and birds, novel IAV strains can emerge, jump species, and cause epidemics, like the latest variant of H5N1. Wastewater-based epidemiology (WBE) has been shown capable of detecting human IAVs. We aimed to assess whether whole-genome sequencing (WGS) of IAVs from wastewater is possible and can be used to discriminate between circulating strains of human and any non-human IAVs, such as those of avian origin.
Immunomodulatory Hydrogel for Electrostatically Capturing Pro‐inflammatory Factors and Chemically Scavenging Reactive Oxygen Species in Chronic Diabetic Wound Remodeling
Authors: Zihao Wang, Mengyu Li, Jia Chen, Shengmin Zhang, Bin Wang, Jianglin Wang
Journal: Advanced Healthcare Materials (2024)

Diabetic wound exhibits the complex characteristics involving continuous oxidative stress and excessive expression of pro-inflammatory cytokines to cause a long-term inflammatory microenvironment. The repair healing of chronic diabetic wounding is tremendously hindered due to persistent inflammatory reaction. To address the aforementioned issues, here, a dual-functional hydrogel is designed, consisting of N1-(4-boronobenzyl)-N3-(4-boronophenyl)-N1, N1, N3, N3-tetramethylpropane-1, 3-diaminium (TSPBA) modified polyvinyl alcohol (PVA) and methacrylamide carboxymethyl chitosan (CMCSMA) can not only electrostatically adsorb proinflammatory cytokines of IL1-β and TNF-α, but can also chemically scavenge the excessive reactive oxygen species (ROS) in situ. Both in vitro and in vivo evaluations verify that the negatively charged and ROS-responsive hydrogel (NCRH) can effectively modulate the chronic inflammatory microenvironment of diabetic wounds and significantly enhance wound remodeling. More importantly, the well-designed NCRH shows a superior skin recovery in comparison with the commercial competitor product of wound dressing. Consequently, the current work highlights the need for new strategies to expedite the healing process of diabetic wounds and offers a wound dressing material with immunomodulation.
Biotics as novel therapeutics in targeting signs of skin ageing via the gut-skin axis
Authors: Jasmine F Millman, Alina Kondrashina, Clodagh Walsh, Kizkitza Busca, Aneesha Karawugodage, Julia Park, Sameera Sirisena, Francois-Pierre Martin, Valeria D Felice, Jonathan A Lane
Journal: Ageing Research Reviews (2024)
Prognostic Impact of Non-predominant Lepidic Components in Pathologic Stage I Invasive Non-Mucinous Adenocarcinoma
Authors: Joonseok Lee, Jae Hyun Jeon, Jin-Haeng Chung, Jung Woo Son, Beatrice Chia-Hui Shih, Woohyun Jung, Sukki Cho, Kwhanmien Kim, Sanghoon Jheon
Journal: Journal of Thoracic Oncology (2024)
Dual CRALBP isoforms unveiled: iPSC-derived retinal modelling and AAV2/5-RLBP1 gene transfer raise considerations for effective therapy
Authors: Krishna Damodar, Gregor Dubois, Laurent Guillou, Daria Mamaeva, Marie Pequignot, Nejla Erkilic, Carla Sanjurjo-Soriano, Hassan Boukhaddaoui, Florence Bernex, Béatrice Bocquet, Jérôme Vialaret, Yvan Arsenijevic, T Michael Redmond, Christopher Hirtz, Isabelle Meunier, Philippe Brabet, Vasiliki Kalatzis
Journal: Molecular Therapy (2024)
Improved event-free survival after complete or major pathologic response in patients with resectable NSCLC treated with neoadjuvant chemoimmunotherapy regardless of adjuvant treatment: a systematic review and individual patient data meta-analysis
Authors: Daniele Marinelli, Antonio Nuccio, Alessandro Di Federico, Francesca Ambrosi, Pietro Bertoglio, Eleonora Faccioli, Roberto Ferrara, Alessandra Ferro, Raffaele Giusti, Francesco Guerrera, Marco Mammana, Alessandra Pittaro, Matteo Sepulcri, Giuseppe Viscardi, Filippo Tommaso Gallina
Journal: Journal of Thoracic Oncology (2024)
Efficient and Safe In Vivo Treatment of Primary Hyperoxaluria Type 1 via LNP-CRISPR/Cas9-mediated glycolate oxidase disruption
Authors: Yanhong Jiang, Shuanghong Chen, Shenlin Hsiao, Haokun Zhang, Da Xie, Zi Jun Wang, Wendan Ren, Mingyao Liu, Jiaoyang Liao, Yuxuan Wu
Journal: Molecular Therapy (2024)
‘Nirmatrelvir/ritonavir treatment and risk for post-acute sequelae of COVID-19 in older Singaporeans’ – Author’s reply
Authors: Liang En Wee, Jue Tao Lim, An Ting Tay, Calvin J. Chiew, Barnaby Edward Young, Betty Wong, Ruth Lim, Ching Li Lee, Joyce Tan, Shawn Vasoo, David Chien Lye, Kelvin Bryan Tan
Journal: Clinical Microbiology and Infection (2024)
Infant-derived human nasal organoids exhibit relatively increased susceptibility, epithelial responses, and cytotoxicity during RSV infection
Authors: Gina M. Aloisio, Divya Nagaraj, Ashley M. Murray, Emily M. Schultz, Trevor McBride, Letisha Aideyan, Erin G. Nicholson, David Henke, Laura Ferlic-Stark, Anubama Rajan, Amal Kambal, Hannah L. Johnson, Elina Mosa, Fabio Stossi, Sarah E. Blutt, Pedro A. Piedra, Vasanthi Avadhanula
Journal: Journal of Infection (2024)

Highlights•Infant-derived compared to adult-derived HNOs have more mucus production at baseline.•During RSV infection, infants produce higher amounts of infectious virus over adults.•Infant HNOs have a more robust cytokine response.•RSV infection causes increased cellular damage in infants compared to adult HNOs.AbstractBackgroundRespiratory syncytial virus (RSV) causes significant morbidity and mortality, especially in young children. Why RSV infection in children is more severe compared to healthy adults is not fully understood.MethodsWe used ex-vivo human nasal organoid platforms from infants and adults to investigate the underlying mechanism of this disease disparity at the initial site of RSV replication, the nasal epithelium.ResultsInfant-derived human nasal organoid-air liquid interface (HNO-ALIs) lines were more susceptible to early RSV replication. Moreover, infant-derived HNO-ALIs elicited a statistically significant greater overall cytokine response, enhanced mucous production, and greater cellular damage compared to their adult counterparts. Furthermore, the adult cytokine response was associated with a superior regulatory cytokine response, which could explain less cellular damage than in infant lines.ConclusionsOur data highlights substantial differences in how infant and adult upper respiratory tract epithelium responds to RSV infection at the cellular level. These differences in epithelial cellular response can lead to impaired mucociliary clearance, a more dysregulated innate immune response predisposing infants to more severe RSV infection compared to adults.
The rs6967330 minor allele in CDHR3 is a significant risk factor for severe acute exacerbations in CRS.
Authors: Sunny Palumbo, Joseph Irish, Nirushan Narendran, Debra A. Stern, Sophia Volpe, Christopher H. Le, Rebekah Starks, Anthony Bosco, Fernando D. Martinez, Eugene H. Chang
Journal: Journal of Allergy and Clinical Immunology (2024)
A comprehensive review on pharmacokinetic mechanism of herb-herb/drug interactions in Chinese herbal formula
Authors: Mengting Li, Yanli Wang, Yi Chen, Lijinchuan Dong, Jieyuan Liu, Yu Dong, Qing Yang, Weiyan Cai, Qi Li, Bo Peng, Yujie Li, Xiaogang Weng, Yajie Wang, Xiaoxin Zhu, Zipeng Gong, Ying Chen
Journal: Pharmacology & Therapeutics (2024)
Efficacy, Safety and Mechanistic Impact of a Heart Failure Guideline-Directed Medical Therapy Clinic
Authors: Aferdita Spahillari, Laura P Cohen, Claire Lin, Yuxi Liu, Ashley Tringale, Kathryn E Sheppard, Christine Ko, Rahul Khairnar, Kristin M Williamson, Jason H Wasfy, Nandita S Scott, Charlotte Paquette, Stephen J Greene, Gregg C Fonarow, James L Januzzi
Journal: JACC Heart Failure (2024)
Impact of a Novel Wearable Sensor on Heart Failure Rehospitalization
Authors: John P Boehmer, Sebastian Cremer, Wael S Abo-Auda, Donny R Stokes, Azam Hadi, Patrick J McCann, Ashley E Burch, Diana Bonderman
Journal: JACC Heart Failure (2024)

There is an unmet need for early detection of heart failure decompensation, allowing patients to be managed remotely and avoid hospitalization.
Rapid Evolution of Metastases in Patients with Treated G3 Neuroendocrine Tumors Associated with NEC-Like Transformation and TP53 Mutation
Authors: Atsuko Kasajima, Nicole Pfarr, Eva-Maria Mayr, Ayako Ura, Elisa Moser, Alexander von Werder, Abbas Agaimy, Marianne Pavel, Günter Klöppel
Journal: Endocrine Pathology (2024)

Abstract Little is known about the morphomolecular features of G3 neuroendocrine tumors (G3NETs) under prolonged systemic treatments, although rapid progression is increasingly observed. This longitudinal study aims to elucidate the course and morphomolecular features of metastasized G3NETs with high-grade transformation. Clinical and histological findings in 40 patients with metastasized and treated G3NETs, which were histologically examined at least twice with an interval time of more than 6 months (median 27), were reviewed and the morphomolecular changes recorded and assigned to treatment. Neuroendocrine carcinoma (NEC)-like histology defined by high-grade atypia, diffuse growth pattern, and/or necrosis was identified in nine (22%) G3NETs (seven pancreatic, two rectal) patients. All NEC-like tumors showed a significantly higher Ki67 increase and longer interval time between first and last examination than non-NEC-like G3NETs (53 vs. 19% and 60 vs. 24 months, respectively). Moreover, all NEC-like G3NETs had TP53 (100%), but rarely RB1 (12%) mutations, and retained NET-typical mutations such as MEN1 or DAXX (five of the pancreatic NETs). The last treatments received prior to the NEC-like transformation included PRRT ( n = 3), somatostatin analog, everolimus, sunitinib ( n = 1 each), and alkylating agents ( n = 2). Abrupt clinical progression in patients with metastasized G3NETs is associated with a significant increase in Ki67, accelerated growth, and NEC-like histology. These findings are most likely attributable to the novel TP53 mutation, which was detected in all nine cases at the last evaluation. However, none of the cases exhibited a complete transformation to a typical NEC, as the tumors retained partial histological and genetic features of NETs.
Development of a prognostic model to predict 90-day mortality in hospitalised cancer patients (PROMISE tool): a prospective observational study
Authors: Oriol Mirallas, Berta Martin-Cullell, Víctor Navarro, Kreina Sharela Vega, Jordi Recuero-Borau, Diego Gómez-Puerto, Daniel López-Valbuena, Clara Salva de Torres, Laura Andurell, Anna Pedrola, Roger Berché, Fiorella Palmas, José María Ucha, Guillermo Villacampa, Alejandra Rezqallah, Judit Sanz-Beltran, Rafael Bach, Sergio Bueno, Cristina Viaplana, Gaspar Molina, Alberto Hernando-Calvo, Juan Aguilar-Company, María Roca, Eva Muñoz-Couselo, Alex Martínez-Martí, Ada Alonso, Simeon Eremiev, Teresa Macarulla, Ana Oaknin, Cristina Saura, Elena Élez, Enriqueta Felip, Ángeles Peñuelas, Rosa Burgos, Patricia Gómez Pardo, Elena Garralda, Josep Tabernero, Sònia Serradell, Sònia Servitja, David Paez, Rodrigo Dienstmann, Joan Carles
Journal: The Lancet Regional Health - Europe (2024)

Prognostic factors for ambulatory oncology patients have been described, including Eastern Cooperative Oncology Group (ECOG), tumor stage and malnutrition. However, there is no firm evidence on which variables best predict mortality in hospitalized patients receiving active systemic treatment. Our main goal was to develop a predictive model for 90-day mortality upon admission.