tbuckley/cabot-search huggingface dataset:
More on Antihypertensive Medications and Cognitive Function in Nursing Home Residents
Authors: Wang Mei, Li Yue, Wang Jiachun
Journal: JAMA Internal Medicine (2025)

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Heterogeneity of Primary Outcomes in Large Atherosclerotic Cardiovascular Disease Trials Published in Prominent Medical Journals
Authors: Daniel Shepshelovich, Dafna Yahav, Danielle R. Rome, Hadar Goldvaser, Ilan Richter, Emilia A. Hermann, R. Graham Barr
Journal: JAMA Internal Medicine (2025)

This cohort study examines heterogeneity in primary end points reported by randomized clinical trials of atherosclerotic cardiovascular disease published in prominent medical journals.
Platform Trials in ALS
Authors: John Turnbull
Journal: JAMA (2025)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2025 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Maternal Downward Neighborhood Income Mobility and Ensuing Severe Neonatal Morbidity
Authors: Jennifer A. Jairam, Eyal Cohen, Christina Diong, Howard Berger, Hilary K. Brown, Jun Guan, Joel G. Ray
Journal: JAMA Pediatrics (2025)

This population-based cohort study examines changes in mothers’ neighborhood income between 2 consecutive births and associated morbidity/mortality outcomes in their newborns.
Knowledge Translation Interventions to Address Gaps in Rectal Cancer Care
Authors: Erin D. Kennedy, Amandeep Pooni, Selina Schmocker, Carl Brown, Anthony MacLean, Nancy N. Baxter, Lara Williams, Marko Simunovic, Sender Liberman, Sébastien Drolet, Katerina Neumann, Kartik Jhaveri, Richard Kirsch
Journal: JAMA Network Open (2025)

Importance Over the last 2 decades, increasing use of multimodal strategies has led to significant improvements in oncologic outcomes for patients with rectal cancer. However, uptake of these strategies varies among centers, suggesting that best evidence is not always implemented into practice. Objectives To identify gaps in care and initiate knowledge translation interventions to close existing gaps. Design, Setting, and Participants This 3-year multifaceted, prospective quality improvement study was conducted at 8 high-volume rectal cancer centers across Canada. From April 2016 to December 2018, patients with stage I to III rectal cancer undergoing total mesorectal excision were enrolled. Data were analyzed from January 2022 through December 2023. Interventions Process measures for multimodal strategies to optimize rectal cancer care were selected and prospectively collected for patients with stage I to III rectal cancer undergoing total mesorectal excision. Knowledge translation interventions were implemented to increase uptake of these strategies. Main Outcome and Measure Change in uptake of process measures over the study period, with measures taken every 3 months, from time 1 (baseline) to time 7 (18 months). Results Among 645 patients with stage I to III rectal cancer (389 male [60.3%]; mean [SD] age, 68.1 [8.2] years), iterative results showed that uptake of 6 of 12 process measures (eg, presentation at multidisciplinary cancer conference: 22 of 77 patients [28.6%] at time 1 to 64 of 91 patients [70.3%] at time 7; P &amp;amp;lt; .001) and 1 pathology measure (inadequate lymph node retrieval: 15 of 77 patients at time 1 [19.5%] to 6 of 91 patients at time 7 [6.6%]; P = .002) improved over time. Positive circumferential resection margin, positive distal margin, and inadequate lymph node retrieval rates at 2 years were 44 patients (6.8%), 10 patients (1.6%), and 79 patients (12.2%), respectively. Conclusions and Relevance In this study, there was an improvement in 6 process measures and 1 pathology measure for patients with stage I to III rectal cancer. Furthermore, this study led to standardized processes of care for rectal cancer that may facilitate continuous quality improvement and multicenter trials across Canada.
More on Antihypertensive Medications and Cognitive Function in Nursing Home Residents—Reply
Authors: Bocheng Jing, W. James Deardorff, Michelle C. Odden
Journal: JAMA Internal Medicine (2025)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2025 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Citation Context Analysis of Autism Mortality and Suicide Findings From Hirvikoski’s Landmark Study
Authors: Brittany N. Hand, Melica Nikahd, Bethany J. Wolf, J. Madison Hyer, Anne Longo, Daniel Gilmore, Lauren Bishop
Journal: JAMA Network Open (2025)

This systematic review evaluates the accuracy of citations to a landmark study on premature mortality among autistic people.
The Value of EHR-Generated Recommendations for Treating Acute Kidney Injury
Authors: Desmond Y. H. Yap, Kwok Ying Chan
Journal: JAMA (2025)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2025 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
More on Antihypertensive Medications and Cognitive Function in Nursing Home Residents
Authors: Ping-Hao Chiang, Chieh-Hsuan Tsai
Journal: JAMA Internal Medicine (2025)

To the Editor Jing et al1 found that deprescribing antihypertensive medication was associated with lower cognitive function impairment in nursing home residents. This important issue in long-term care outside of hospitals warrants further exploration.
Supplemental Security Income for Low-Birth-Weight Infants—Addressing Gaps in Coverage
Authors: Erika Gabriela Cordova-Ramos, Emily Miller, Susanne Klawetter
Journal: JAMA Pediatrics (2025)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2025 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Calcium Intake and Risk of Colorectal Cancer in the NIH-AARP Diet and Health Study
Authors: Semi Zouiouich, David Wahl, Linda M. Liao, Hyokyoung G. Hong, Rashmi Sinha, Erikka Loftfield
Journal: JAMA Network Open (2025)

Importance Calcium intake is associated with a reduced risk of colorectal cancer (CRC), although it remains unclear whether this association varies by calcium source or tumor site. Moreover, there are disparities in calcium intake by race and ethnicity, but the impact of low calcium consumption on CRC risk in specific racial and ethnic populations is unclear. Objective To investigate the association between calcium intake and CRC risk, considering the source of calcium and tumor site and across racial and ethnic groups. Design, Setting, and Participants This cohort study analyzed data from the National Institutes of Health–AARP Diet and Health Study. Participants were aged 50 to 71 years at baseline (October 1995 to May 1996), had self-reported good health and neither extremely high nor low caloric or calcium intake, and were followed up until the date of their first primary cancer diagnosis, death, loss to follow-up, or end of follow-up (December 31, 2018). Data were analyzed from April 2022 to April 2024. Exposure Calcium intake was estimated from dietary sources (dairy and nondairy), supplements, and total intake. Main Outcomes and Measures The primary outcome was CRC incidence. Multivariable-adjusted Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% CIs using the lowest sex-specific quintile of calcium intake as the reference. Results Among 471 396 participants who were cancer-free at baseline, mean (SD) baseline age was 62.0 (5.4) years and 59.5% were male. During 7 339 055 person-years of follow-up (median, 18.4 years [IQR, 9.2-22.5 years]), 10 618 first primary CRC cases were identified. Mean (SD) total calcium intake for the lowest quintile (Q1) was 401 mg/d (104 mg/d) for females and 407 mg/d (95 mg/d) for males and for the highest quintile (Q5) was 2056 mg/d (412 mg/d) for females and 1773 mg/d (444 mg/d) for males. Dairy, nondairy, and supplemental sources contributed a mean (SD) of 42.1% (43.5%), 34.2% (24.5%), and 23.7% (38.3%) of total calcium intake, respectively. Higher total calcium intake (Q5 vs Q1) was associated with a lower risk of CRC (hazard ratio [HR], 0.71; 95% CI, 0.65-0.78; P &amp;amp;lt; .001 for trend), with consistent results across calcium sources and tumor sites. Among non-Hispanic Black participants, the mean (SD) calcium intake was 382 mg/d (108 mg/d) for Q1 and 1916 mg/d (466 mg/d) for Q5, with no association of total calcium intake with CRC risk (Q5 vs Q1: HR, 0.60; 95% CI, 0.32-1.13; P = .12 for trend); there was no evidence of effect measure differences by race and ethnicity. Conclusions and Relevance In this cohort study, higher calcium intake was consistently associated with reduced CRC risk across tumor sites and sources of calcium. Increasing calcium intake, especially among groups with lower consumption, may be associated with reductions in avoidable differences in CRC risk.
Thoracoabdominal Normothermic Regional Perfusion—It Is Not All About the Heart
Authors: Gabriel C. Oniscu
Journal: JAMA Network Open (2025)

Isaac S. Alderete, MHS; Arya Pontula, BSPH; Samantha E. Halpern, MD, MHS; Kunal J. Patel, MD, PhD; Jacob A. Klapper, MD, MHS; Matthew G. Hartwig, MD, MHS
Computer Vision in Clinical Neurology
Authors: Maximilian U. Friedrich, Samuel Relton, David Wong, Jane Alty
Journal: JAMA Neurology (2025)

Importance Neurological examinations traditionally rely on visual analysis of physical clinical signs, such as tremor, ataxia, or nystagmus. Contemporary score-based assessments aim to standardize and quantify these observations, but these tools suffer from clinimetric limitations and often fail to capture subtle yet important aspects of human movement. This poses a significant roadblock to more precise and personalized neurological care, which increasingly focuses on early stages of disease. Computer vision, a branch of artificial intelligence, has the potential to address these challenges by providing objective measures of neurological signs based solely on video footage. Observations Recent studies highlight the potential of computer vision to measure disease severity, discover novel biomarkers, and characterize therapeutic outcomes in neurology with high accuracy and granularity. Computer vision may enable sensitive detection of subtle movement patterns that escape the human eye, aligning with an emerging research focus on early disease stages. However, challenges in accessibility, ethics, and validation need to be addressed for widespread adoption. In particular, improvements in clinical usability and algorithmic robustness are key priorities for future developments. Conclusions and Relevance Computer vision technologies have the potential to revolutionize neurological practice by providing objective, quantitative measures of neurological signs. These tools could enhance diagnostic accuracy, improve treatment monitoring, and democratize specialized neurological care. Clinicians should be aware of these emerging technologies and their potential to complement traditional assessment methods. However, further research focusing on clinical validation, ethical considerations, and practical implementation is necessary to fully realize the potential of computer vision in clinical neurology.
The Value of HER-Generated Recommendations for Treating Acute Kidney Injury—Reply
Authors: Abinet M. Aklilu, Steven Menez, F. Perry Wilson
Journal: JAMA (2025)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2025 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trends and Disparities in the Use of Immunotherapy for Triple-Negative Breast Cancer in the US
Authors: Jincong Q. Freeman, Dezheng Huo, Sarah P. Shubeck, Nan Chen, Sudha R. Yarlagadda, Rita Nanda, Frederick M. Howard
Journal: JAMA Network Open (2025)

Importance Triple-negative breast cancer (TNBC) disproportionately affects Black women. Immunotherapy improves outcomes in early-stage TNBC (esTNBC) and metastatic TNBC (mTNBC). However, racial and ethnic disparities in immunotherapy receipt and its potential association with oncologic outcomes are unknown. Objective To examine trends and racial and ethnic disparities in immunotherapy receipt and differences in pathologic complete response (pCR) and overall survival (OS) in TNBC. Design, Setting, and Participants This retrospective cohort study analyzed the 2019-2021 National Cancer Database. Data were analyzed from April 1 to August 31, 2024. The esTNBC cohort included patients with stage II to III TNBC treated with neoadjuvant therapy in 2021. The mTNBC cohort included patients with stage IV TNBC treated from 2019 to 2021, with all patients having received chemotherapy with or without immunotherapy. Main Outcomes and Measures Immunotherapy use, pCR, and OS with respect to race and ethnicity. Results A total of 10 724 patients with TNBC were included (mean [SD] age, 56.1 [13.7] years; 473 [4.4%] Asian or Pacific Islander, 2569 [24.0%] Black, 981 [9.1%] Hispanic, 6465 [60.3%] White, and 236 [2.2%] other). Immunotherapy use increased from 5.5% in 2017 to 38.8% in 2021 for mTNBC and from 4.2% in 2017 to 48.0% in 2021 for esTNBC. Of 7655 cases of esTNBC diagnosed in 2021, immunotherapy use was lower in Black patients (788 of 1715 [45.9%]), but this difference was not significant after adjusting for insurance status, treatment facility type, and other key variables. Among patients with esTNBC receiving immunotherapy, pCR was similar by race and ethnicity. Of 3069 cases of mTNBC diagnosed from 2019 to 2021, immunotherapy use was higher in Asian or Pacific Islander patients (36 of 97 [37.1%]) and lower in Black patients (238 of 848 [28.1%]). Black patients had lower odds of immunotherapy receipt than White patients (adjusted odds ratio, 0.63; 95% CI, 0.49-0.80) even after controlling for confounders. Among patients receiving immunotherapy, OS was similar between Black and White patients (adjusted hazard ratio, 0.92; 95% CI, 0.64-1.32). Conclusions and Relevance In this cohort study of TNBC, Black patients with mTNBC were less likely to have received immunotherapy, even after controlling for socioeconomic factors. In both esTNBC and mTNBC cohorts, patients who received immunotherapy attained similar outcomes across racial and ethnic groups; thus, efforts should be made to ensure equal access to immunotherapy.
Integrating Buprenorphine Into Chronic Pain Treatment—Putting the Choice in VOICE
Authors: Michael A. Incze, Timothy S. Anderson
Journal: JAMA Internal Medicine (2025)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2025 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Spaceflight Associated Neuro-ocular Syndrome (SANS) and Its Countermeasures
Authors: Tuan Nguyen, Joshua Ong, Tyson Brunstetter, C Robert Gibson, Brandon R Macias, Steven Laurie, Thomas Mader, Alan Hargens, Jay C Buckey, Mimi Lan, Peter Wostyn, Cihan Kadipasaoglu, Scott M Smith, Sara R Zwart, Benjamin J Frankfort, Sarah Aman, Jessica M Scott, Ethan Waisberg, Mouayad Malsalkhi, Andrew G Lee
Journal: Progress in Retinal and Eye Research (2025)