tbuckley/cabot-search huggingface dataset:
Abstract 4138225: In-Hospital Outcomes of Percutaneous Coronary Intervention (PCI) in patients primarily admitted with ST-Elevation Myocardial Infarction (STEMI) at PCI centers versus patients transferred from non-PCI centers, a retrospective study involving the National Inpatient Sample (NIS 2016-2021) database.
Authors: Mark Anthony Ntow, Walter Agyeman, Binit Aryal, Neel Patel
Journal: Circulation (2024)

Background: Timely transfer for PCI is paramount in the management of STEMI. This has been shown to reduce myocardial damage, optimize reperfusion therapy and mitigate the post procedural complications associated with PCI. This study's aim was to describe the in-hospital outcomes associated with acute inter-hospital transfer of patients with STEMI for PCI in comparison with patients directly admitted to a primary PCI center. Methods: The National Inpatient Sample (NIS) was used to identify patients who underwent PCI for STEMI between the years 2016-2021. Based on several transfer indicators, primarily admitted patients and patients with acute inter-hospital transfer were identified. Logistic and linear regression models were used to analyze the primary outcome of in-hospital mortality and secondary outcomes of length of hospital stay, hospital charge, and occurrences of post-procedure complications. Results: Observations were weighted to obtain a national estimate of 748,430 patients with known transfer status who underwent PCI for STEMI. Of these, 625,520 patients were primarily admitted at PCI centers and 122, 910 patients were transferred from non-PCI centers. The mean age of patients with STEMI undergoing PCI was 62 years, and 72 % of the patients were male. There was no significant difference in mortality between patients transferred and patients primarily admitted for PCI due to STEMI. However, patients transferred had longer hospital stay and significantly higher healthcare cost, with a mean difference of 0.72 days (95% CI: 0.65 - 0.81 days, p-value &lt;0.000) and $3,354 (95% CI: $339 - $6371, p-value &lt;0.029), respectively. Patients transferred also had significantly higher odds of post procedure complications, including cardiogenic shock (Odds ratio: 1.49, 95% CI: 1.08 - 2.06, p-value &lt;0.014), cerebrovascular accident (Odds ratio: 3.64 , 95% CI: 1.15 - 11.45, p-value &lt;0.014) and kidney failure (Odds ratio: 2.10 , 95% CI: 1.09 - 4.02, p-value &lt;0.026). Conclusion: Patients with STEMI who were transferred for PCI experienced longer hospital stay and incurred higher healthcare costs. These patients had significantly higher odds of post procedure complications including cardiogenic shock, cerebrovascular accidents and kidney failure.
Abstract 4138220: Traditional and HIV-specific Risk Factors Are Associated with Incident Non-valvular Atrial Fibrillation and Atrial Flutter among Underrepresented Racial and Ethnic Minority Groups Living with HIV
Authors: Elizabeth Kobe, Robert Clare, Karen Chiswell, Chris Longenecker, Keith Marsolo, Eric Meissner, Nwora Okeke, April Pettit, Gretchen Sanders, Kevin Thomas, Gerald Bloomfield, Nishant Shah
Journal: Circulation (2024)

Introduction: With effective antiretroviral therapy (ART), HIV can now be managed as a chronic disease. Chronic disease and cardiovascular risk factor management is especially important for underrepresented racial and ethnic minority groups (UREG). Non-valvular atrial fibrillation and atrial flutter (NVAF) have not been adequately studied in UREG with HIV. Research Questions: Among UREG with HIV, what is the incidence of NVAF? What factors are associated with incident NVAF? Aims: To narrow an evidence gap among UREG with HIV by 1) describing the incidence of NVAF and 2) identifying factors associated with incident NVAF. Methods: This is an ancillary study of the Pathways to Cardiovascular Disease Prevention and Impact of Specialty Referral in Underrepresented Racial and Ethnic Minorities with HIV (PATHWAYS) study, a retrospective population-based study of HIV care patterns among UREG with HIV. Patients without a known history of NVAF entered our study cohort at the date of their first documented HIV diagnosis. We computed the cumulative incidence of NVAF over five years of follow-up (mean 3.4, SD 1.6), handling death as a competing risk. Cox regression analysis was used to examine the univariate associations between characteristics at HIV diagnosis and incident NVAF, adjusting for site and date of HIV diagnosis. Results: From 2015-2019, 10,945 UREG meeting entry criteria were identified. On average, patients were 67.1% male, 94.4% Black, and 8.5% Hispanic. Average CHA2DS2VASc score was 0.92 (SD 1.1) and 63.4% were on ART. Cumulative incidence of NVAF at one and five years after HIV diagnosis were 0.48% (95% CI 0.36-0.63) and 2.16% (95% CI 1.85-2.51), respectively. HIV-related factors associated with incident NVAF included baseline CD4 count &lt;200 (HR 1.84, 95% CI 1.20-2.80) and initial ART including protease inhibitors (HR 1.56, 95% CI 1.14-2.13) and/or integrase strand transfer inhibitors (HR 1.47, 95% CI 1.08-1.99). Additional associated factors included older age, Medicare, cardiology visit(s) in prior year, and co-morbid diseases including hypertension, hyperlipidemia, coronary and peripheral artery disease, prior stroke/transient ischemic attack, heart failure, and chronic kidney disease. Conclusions: In a large cohort of UREG living with HIV, both traditional and HIV-specific risk factors are associated with increased risk of incident NVAF. Interventions to mitigate NVAF risk in this population will require interdisciplinary, team-based approaches.
Abstract 4138221: Ezetimibe plus statin combination vs. double dose statin for patients with dyslipidemia and ASCVD risk: A Systematic Review and Meta-Analysis
Authors: Abdelrahman Mahmoud, Yazan Almohtasib, Ahmed Naeem, Ali Ashraf Salah Ahmed, Mohamed Ramadan, Ahmed A. Ibrahim, Ahmed Mazen Amin, Yasmine Adel Mohammed, Husam Abusuilik, Omar Abdelwahab, Hazem Salah Rezq, Majd M. AlBarakat, Hazem Mohamed Salamah, Salem Elshenawy, Basel Abdelazeem
Journal: Circulation (2024)

Background: Dyslipidemia is a major risk factor for Atherosclerotic Cardiovascular Disease (ASCVD). Statin is a crucial intervention to fix dyslipidemia and reduce the ASCVD risk. Still, there are several regimens to achieve blood lipid level targets, including increasing the statin dose or adding ezetimibe to the statin used. However, the best option between the two regimens is still a matter of debate. Research Question: We aim to evaluate the efficacy and safety of Ezetimibe plus any type of statin versus a double dose of the same statin in patients with ASCVD risk. Methods: A systematic review and meta-analysis based on randomized controlled trials (RCTs) obtained from PubMed, Embase Cochrane, Scopus, and WOS till December 2023. We used the random-effects model to report dichotomous outcomes using odds ratio (OR) and continuous outcomes using mean difference (MD), with a 95% confidence interval (CI). Results: Forty-seven studies with a total of 18592 patients were included. Ezetimibe plus statin was associated with a decrease in low-density lipoprotein (LDL) levels [MD: -13.69 with 95% CI (-15.64, -11.74), P &lt;0.01], and more patients achieving their targeted LDL levels [OR: 2.89 with 95% CI (2.40, 3.47), P &lt;0.01]. However, there was no significant difference between the two groups regarding any adverse events [OR: 0.98 with 95% CI (0.89, 1.08), P =0.62], and the composite endpoint of cardiovascular death, major coronary events, or nonfatal stroke [OR: 0.72 with 95% CI (0.39, 1.32), P = 0.29], although there was a trend towards better results for patients with the combination regimen. Conclusion: Ezetimibe plus statin combination led to more reduced LDL levels and more patients achieving their goal levels than double dose statin, without a significant difference in the rate of any adverse events occurrence. More RCTs are mandatory to assess the effect of both regimens on major clinical events such as stroke, coronary events, and death.
Abstract 4138217: A Machine Learning-Based Novel Risk Score Model for Spontaneous Coronary Artery Dissection
Authors: Ankit Agrawal, Aro Daniela Arockiam, umesh bhagat, Elio Haroun, Muhammad Majid, Tom Kai Ming Wang
Journal: Circulation (2024)

Background: Spontaneous coronary artery dissection (SCAD) remains a poorly understood differential diagnosis of acute coronary syndrome (ACS). We aimed to develop a machine learning-based risk score model to predict in-hospital mortality in patients with SCAD. Methods: The National Inpatient Sample (NIS) 2016-2020 database was used to identify all adult patients (≥18 years of age) with SCAD, identified using ICD-10 code I25.42. Relevant clinical characteristics and outcomes were extracted. The primary endpoint was in-hospital all-cause mortality. The dataset was randomly split into 3 subsets: training, validation, and testing, with a ratio of 0.7, 0.2, and 0.1, respectively. The risk score was generated using R software’s Autoscore package, which is a machine learning-based automatic clinical score generator, and performance was evaluated using the area under receiver-operative characteristics curve (AUC) with 95% confidence intervals (95%CI). Results: Among the 8,260 SCAD patients identified [age 60.9±14.4 years, female 4,708 (57%)], there were 480 (5.8%) primary outcome events. Out of the top 20 covariates seen in the Parsimony plot, we used six for our risk score (0–100): age, comorbidity burden, cardiogenic shock, balloon pump, extracorporeal membrane oxygenation, and race (Figure 1A). The AUC for the derivation and validation cohorts was 0.862 (0.817–0.907) and 0.833 (0.788–0.879), respectively (Figures 1B and 1C). Conclusion: We developed and internally validated a machine learning-based risk score model to predict outcomes in patients with SCAD with a high AUC of 0.833 (0.788–0.879). Risk score models guide decision-making, and future studies are needed for external validation of our findings.
Abstract 4119908: Outcomes for heart failure patients with reduced ejection fraction attending emergency department and discharged within 24 hours versus those admitted patients in heart failure unit.
Authors: Mohamed Alalawi, Taheba Begum, Aya Eltahir, Mark Peterzan, Kristopher Knott, Robin Ray, Nesan Shanmugam, Lisa Anderson, Heba Ghazal, Fadi Jouhra, Elizabeth Lilly Macken
Journal: Circulation (2024)

Introduction: Heart failure (HF) is a clinical syndrome with increasing prevalence. Currently, there are extensive evidence-based therapies targeted at managing patients with heart failure and reduced ejection fraction (HFrEF) to improve outcomes. The National Heart Failure Audit shows the quality of inpatient care (specialist review, discharge medication etc) is related to outcome. This study aimed to evaluate the current practice at a London tertiary centre hospital in managing patients with heart failure and compared outcomes in patients who had a short course of admission (less than 1 day) with those who had a more prolonged course of admission. Method: Retrospective data was collected from a London tertiary centre hospital database for consecutive patients from Sep/2022 till Sep/2023. Statistical analysis was performed using Chi-Square test. The eligibility criteria included a new or previous diagnosis of HF with left ventricular ejection fraction (LVEF) &lt; 40%. Patients were divided into two groups: Group A included 40 eligible patients who were admitted and discharged from the emergency department (ED) within 24 hours. Group B included 37 eligible patients who were admitted and discharged from the dedicated heart failure unit after 10-15 days of hospital admission. Results: In Group A, prescribing guideline-directed medical therapy (GDMT) was lower compared to Group B; Renin-Angiotensin-Aldosterone Inhibitors (47.50% vs. 94.59%), beta blockers (55% vs. 91.89%), mineralocorticoid receptor antagonists (12.50 %vs. 94.59%), and sodium-glucose co-transporter 2 inhibitors (15% vs. 89.19%). More patients in Group B received all four pillars of GDMT (86.49%) compared to Group A (5%). At 6-month follow-up,18.75% were on 4 GDMT in Group A versus 92% in group Group B. Re-admission within 6 months was higher in Group A (30%) compared to Group B (16.22%); however, the difference was not statistically significant (P value: 0.153). Higher mortality rates were observed in Group A (mortality rate: 20%) compared to Group B (mortality rate: 2.70%), with statistical significance (P value: 0.018). Conclusion: This study showed that HFrEF patients admitted to a specialist heart failure unit achieve higher rates of GDMT and have significantly improved outcomes compared to those who had a shorter inpatient stay and discharged from the emergency department. These findings underscore the high risks associated with rapid discharge from hospital on incomplete medical therapy.
Abstract Su908: Unfavorable prognostic features and temporal trends in Out-of-Hospital Cardiac Arrests (OHCA) presenting to an Academic Center at the Border in El Paso
Authors: Aravind Sekhar, Sahithi Sharma, Bobby Zakhireh, Mario Carrasco, Sunil Srinivas, Debabrata Mukherjee
Journal: Circulation (2024)

Introduction: Early recognition of cardiac arrest with bystander cardiopulmonary resuscitation (CPR), and early defibrillation when appropriate, can improve outcomes after Out of Hospital Cardiac Arrest (OHCA). Data from the national registries indicate there are both regional as well racial and ethnic differences in rates of bystander CPR in witnessed OHCA cases with significantly lower rates of bystander CPR in non-white persons. However, Hispanic as well border populations are underrepresented in these studies. University Medical Center (UMC) El Paso, Texas is an academic medical center located 1 mile from the US- Mexico border which is also the only not for profit safety net hospital with a Level1 trauma center. Research Question: Outcomes after OHCA are strongly affected by peri-arrest circumstances including bystander CPR and certain features portend poor outcomes. We performed a descriptive observational study of OHCA cases presenting to UMC to analyze temporal trends in these factors in our community as local data from El Paso is currently not reported in any registries. Methods: We collaborated with the El Paso Fire Department (EPFD) to obtain resuscitation data on patients who suffered OHCA and were brought to the University Medical Center (UMC)Emergency Department (ED) and created a registry of patients who suffered OHCA in El Paso FROM 2017 to Nov 2021. Results: Initial analysis identified around 698 predominantly Hispanic patients who suffered OHCA. Of these 115 were due to non-cardiac causes such as trauma, and 583 were possible cardiac etiology. OHCA cases peaked in 2020 coinciding with COVID 19 surge. Less than one third (31.5%) had bystander CPR with only 11.9% having a shockable rhythm. 64% did not achieve Return of spontaneous circulation in the field. 39% expired in the ED or in the field. We also performed a temporal analysis of these features and bystander CPR rates peaked in 2019 (38.1%to 24.8% in 2021). Conclusion: In our Hispanic underserved population in El Paso, we identified poor outcomes after OHCA, with non-shockable rhythm being the most common adverse feature and decreased rates of bystander CPR (31.5%) with further decrease after 2019. Local community level data which is critical for appropriate local resource allocation to improve OHCA outcomes is missing from underserved populations and additional resources are required improve outcomes.
Abstract Su401: Confidence in performing CPR after training with traditional and female-breasted manikins
Authors: Shaveta Khosla, Ahana Gupta, Chinenye Ukpaby, Courtney Schwerin O'Reilly, Elizabeth Froelich, Comilla Sasson, Pavitra Kotini-Shah
Journal: Circulation (2024)

Introduction: Studies have documented that females experiencing an OHCA are significantly less likely to receive cardiopulmonary resuscitation (CPR) than males in public locations. Reasons for this disparity include bystanders fear of being perceived as sexualizing or assaulting females during CPR, concerns about physically injuring females, or low confidence in rendering CPR on females. This pilot study aimed to assess the confidence of CPR trainees who were trained on both traditional and female-breasted manikins. Methods: Participants were enrolled at a community bystander CPR training for teachers at an urban public school in 2024. Participants who consented to participate in the study were asked to complete surveys. All participants received a didactic on hands-only CPR, followed by two sets of hands-on practice, first with a traditional manikin, and then with a female-breasted manikin or vice versa. Results: Of the 112 participants enrolled in the study, 88.4% were women, and 14% were &gt;50 years of age. The sample was almost all White participants, with high education status (88.4% with a Master’s or college education). The majority (86.6%) had prior CPR training, but most of them reported receiving training more than a year ago. After the two sets of practice (one with traditional manikin, and one with female manikin), 84.7% felt confident to perform CPR on both males and females, while 9.9% felt more confident to perform CPR on female and 5.4% on male. Men and women (84.6% and 84.7%, respectively) felt equally confident in performing CPR on both males and females. Although 28.4% felt either ‘slightly uncomfortable’ or ‘very uncomfortable’ with use of the female manikin, after practicing on a female manikin, 81.6% felt more comfortable with doing CPR on women (11.1% still felt uncomfortable and 7.3% were neutral). When asked which manikin made them feel more confident in performing CPR, 70.9% reported both, while 7.2% said neither, 10% said female manikin and 11.8% selected traditional manikin. 70% of women and 75% of men selected both manikins. Conclusion: Training with both types of anatomically accurate manikins is important in improving confidence of community lay responders in performing CPR and reducing community level gender disparities. Future analysis will evaluate change in confidence with each manikin type and assess confidence and knowledge retention 6 months after the training.
Abstract Su505: Impact of a Targeted Automated External Defibrillator (AED) Program on Survival After Ventricular Fibrillation Cardiac Arrest in the Sao Paulo Metropolitan Subway System: A Landmark Initiative in Latin America
Authors: Sergio Timerman
Journal: Circulation (2024)

The targeted Automated External Defibrillator (AED) program in the Sao Paulo Metro has yielded promising results in improving survival rates for individuals experiencing out-of-hospital cardiac arrest (OHCA) due to ventricular arrhythmias. A longitudinal observational study conducted from September 2006 to November 2023 assessed the program's impact on survival outcomes. The implementation of the full program led to a significant improvement in survival to hospital discharge with minimal neurological impairment (0% vs. 43%, P=0.001). These findings underscore the importance of a targeted AED program in improving survival outcomes for OHCA, particularly in densely populated urban environments such as the Sao Paulo Metro. The short interval between arrest and defibrillation emerged as a critical factor in achieving favorable long-term, neurologically intact survival rates. The success of this program advocates for the strategic expansion of targeted AED initiatives in other large Latin American cities, emphasizing the potential to save lives and enhance public health outcomes through proactive emergency medical response measures.
Abstract Su606: PulsePoint Alert Location Features in a Mid-Sized Metropolitan Area
Authors: Leo Kates, Alexandria Chiaberta, Jorge Gumucio, Leonard Weiss, Ankur Doshi, David Salcido
Journal: Circulation (2024)

Introduction: PulsePoint is a smartphone-based system that alerts layperson responders to out-of-hospital cardiac arrest (OHCA) events in non-residential locations within the United States. These locations can be classified to inform public access defibrillator (PAD) placement and focus responder training and recruitment efforts in high-frequency areas. Our objective was to manually classify the locations of PulsePoint alerts to better understand how PulsePoint performs across a variety of location types. Methods: Records were obtained for each PulsePoint alert in Allegheny County, PA, USA (pop. 1.2M) from 06/24/2016 to 10/28/2020. PulsePoint generates an alert when a potential OHCA occurs in public and is within 400m of at least one responder. Alert data contains address and location name, and the number and locations of nearby responders and PADs. We placed each location into one of the following categories: “education”, “consumer goods/services”, “restaurants/bars”, “transit hubs”, “hotels”, “entertainment venues”, “recreational facilities”, “government/municipal”, “offices”, “industrial/manufacturing”, “religious institutions”, “parks/outdoor spaces”, “sidewalk/street”, and “shelters/supportive housing”. “Unspecified/unknown” was used for locations that could not be classified due to insufficient information. We excluded all outpatient health, assisted-living, daycare, and correctional facilities. For each location category, we calculated the event count and the median number of nearby responders and PADs. Results: There were 994 included events during the capture period. The most frequent location category was “sidewalk/street”, which represented 24 percent of all alerts; the least frequent was “transit hubs”, which represented 0.7 percent of all alerts. “Shelters/supportive housing” had the highest median number of responders (7, IQR 1-14), while “industrial/manufacturing” had the lowest (1, IQR 1-3.5). “Transit hubs” had the highest median number of PADs (31, IQR 31-41), while “parks/outdoor spaces” had the lowest (0.5, IQR 0-1). Conclusion: PulsePoint alert-generating events occur across a wide variety of location types. Further research is needed to understand the accuracy of the system’s location data versus EMS dispatch records. Nonetheless, the data may have implications for system improvement by highlighting which location types have low numbers of nearby responders and PADs and may benefit from strategic PAD placements and training efforts.