THE RELATION OF GASTRIC SECRETION TO HEMATOPOIESIS
Authors: Theodore G. Klumpp, Simon Koletsky
Journal: Annals of Internal Medicine (1935)

Article1 March 1935THE RELATION OF GASTRIC SECRETION TO HEMATOPOIESISTHEODORE G. KLUMPP, SIMON KOLETSKYTHEODORE G. KLUMPPSearch for more papers by this author, SIMON KOLETSKYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-9-991 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIn 1833 Beaumont1noted, "In febrile diathesis, or predisposition, from whatever cause—obstructed perspiration, undue excitement by stimulating liquors, overloading the stomach with food—fear, anger, or whatever depresses or disturbs the nervous system—the villous coat becomes sometimes red and dry, at other times pale and moist, and loses its smooth and healthy appearance; the secretions become vitiated, greatly diminished, or entirely suppressed; the mucous coat scarcely perceptible; the follicles flat and flaccid, with secretion insufficient to protect the vascular and nervous papillae from irritation. . . . When considerable, and particularly, when there are corresponding symptoms of disease, no gastric...References1. BEAUMONT W: Experiments and observations on the gastric juice and the physiology of digestion, 1833, F. P. Allen, Plattsburgh, New York. Google Scholar2. FABERLANGE KG: Die Pathogenese und Aetiologie der chronischen Achylia gastrica, Ztschr. f. klin. Med., 1908, lxvi, 53-89. Google Scholar3. RIEGEL F: Die Erkrankungen des Magens, 1908, vol. 2, Alfred Hölder, Vienna and Leipzig. Google Scholar4. EINHORN M: On achylia gastrica, New York Med. Rec., 1892, xli, 650-654. Google Scholar5. OPPLER B: Über die Abhängigkeit gewisser chronischer Diarrhöen von mangelnder Sekretion des Magensaftes, Deutsch. med. Wchnschr., 1896, xxii, 511-514. CrossrefGoogle Scholar6. TABORA D: Die Darmerscheinungen bei Achylia gastrica, München. med. Wchnschr., 1904, li, 865-868. Google Scholar7. WILKINSONOLIVER JFTH: Some clinical conditions associated with achlorhydria, Lancet, 1931, i, 66-71. CrossrefGoogle Scholar8. KEEFERBLOOMFIELD CSAL: The significance of gastric anacidity, Bull. Johns Hopkins Hosp., 1926, xxxix, 304-329. Google Scholar9. EGGLESTON EL: Pathological conditions secondary to achlorhydria, Jr. Am. Med. Assoc., 1931, xcvii, 1216-1221. CrossrefGoogle Scholar10. POLLANDBLOOMFIELD WSAL: Unexplained gastric anacidity, Arch. Int. Med., 1931, xlviii, 412-417. CrossrefGoogle Scholar11. BLOOMFIELDPOLLAND ALWS: Gastric anacidity, 1933, Macmillan Co., New York. Google Scholar12. HARTFALL SJ: Some observations on achlorhydria and anemia, Brit. Med. Jr., 1934, i, 136-141. CrossrefGoogle Scholar13. CASTLE WB: Observations on the etiological relationship of achylia gastrica to pernicious anemia. I. The effect of the administration to patients with pernicious anemia of the contents of the normal human stomach recovered after the ingestion of beef muscle, Am. Jr. Med. Sci., 1929, clxxviii, 748-764. CrossrefGoogle Scholar14. CASTLETOWNSEND WBWC: Observations on the etiological relationship of achylia gastrica to pernicious anemia. II. The effect of the administration to patients with pernicious anemia of beef muscle after incubation with normal gastric juice, Am. Jr. Med. Sci., 1929, clxxviii, 764-777. CrossrefGoogle Scholar15. CASTLETOWNSENDHEATH WBWCCW: Observations on the etiological relationship of achylia gastrica to pernicious anemia. III. The nature of the reactions between normal human gastric juice and beef muscle leading to clinical improvement and increased blood formation similar to the effect of liver feeding, Am. Jr. Med. Sci., 1930, clxxx, 305-335. CrossrefGoogle Scholar16. CASTLEHEATHSTRAUSS WBCWMB: Observations on the etiological relationship of achylia gastrica to pernicious anemia. IV. A biological assay of the gastric secretion of patients with pernicious anemia, Am. Jr. Med. Sci., 1931, clxxxii, 741-764. CrossrefGoogle Scholar17. MORRISSCHIFF RSL: Reticulocyte response in pernicious anemia following intramuscular injection of gastric juice, Jr. Med., 1932, xiii, 27. Google Scholar18. MORRISSCHIFFBERGERSHERMAN RSLGJE: A specific hematopoietic hormone in normal gastric juice, Jr. Am. Med. Assoc., 1932, xcviii, 1080-1081. CrossrefGoogle Scholar19. MORRISSCHIFFBERGERSHERMAN RSLGJE: The hematopoietic response in pernicious anemia following the intramuscular injection of gastric juice, Am. Jr. Med. Sci., 1932, clxxxiv, 778-7S2. CrossrefGoogle Scholar20. FENWICK S: On atrophy of the stomach in relation to pernicious anemia, Lancet, 1877, ii, 1-4, 39-41, 77-78. CrossrefGoogle Scholar21. FENWICK S: On atrophy of the stomach, 1880, J. and A. Churchill, London. Google Scholar22. ADDISON T: A collection of the published writings of the late Thomas Addison, 1868, New Sydenham Society, London. Google Scholar23. QUINKE H: Weiteren Beobachtungen über perniciöse Anämie, Deutsch. Arch. f. klin. Med., 1877, xx, 1-31. Google Scholar24. KINNICUTT FP: Atrophy of the gastric tubules—its relation to pernicious anemia, Am. Jr. Med. Sci., 1887, xciv, 419-443. CrossrefGoogle Scholar25. HENRYOSLER FPW: Atrophy of the stomach with the clinical features of progressive pernicious anemia, Am. Jr. Med. Sci., 1886, xci, 498-511. CrossrefGoogle Scholar26. CAHNVON MEHRING AJ: Die Säuren des gesunden und kranken Magens, Deutsch. Arch. f. klin. Med., 1886, xxxix, 233-253. Google Scholar27. GRAWITZ E: Klinische Pathologie des Blutes, 1896, O. Enslin, Berlin. Google Scholar28. FABERBLOCH KCE: Über die pathologischen Veränderung im Digestiontractus bei der perniciösen Anämie, Ztschr. f. klin. Med., 1900, xl, 98-141. Google Scholar29. LEVINELADD SAWS: Pernicious anemia: a clinical study of 150 consecutive cases with special reference to gastric anacidity, Bull. Johns Hopkins Hosp., 1921, xxxii, 254-266. Google Scholar30. BARNETT CW: The significance of gastric secretions in pernicious anemia, Am. Jr. Med. Sci., 1931, clxxxii, 170-177. CrossrefGoogle Scholar31. HARVEYMURPHY EAWP: Pernicious anemia without achlorhydria, ANN. INT. MED., 1933, vi, 1393-1406. LinkGoogle Scholar32. SHAW ME: A case of apparent recovery from Addison's anemia and the associated achlorhydria, Guy's Hosp. Rep., 1926, lxxvi, 294-302. Google Scholar33. HURST AF: Restoration of gastric secretion in Addison's anemia by treatment of the gastritis, Guy's Hosp. Rep., 1930, lxxx, 407-410. Google Scholar34. MCPEAKNEIGHBORS EMD: Minot-Murphy diet in pernicious anemia: report of five cases, South. Med. Jr., 1927, xx, 926-931. CrossrefGoogle Scholar35. FABER K: Anämische Zustande bei der chronischen Achylia gastrica, Berlin. klin. Wchnschr., 1913, l, 958-962. Google Scholar36. FABERGRAN KHC: Relation between gastric achylia and simple and pernicious anemia, Arch. Int. Med., 1924, xxxiv, 658-668. CrossrefGoogle Scholar37. HURST AF: Achlorhydria: its relation to pernicious anemia and other diseases, Lancet, 1923, i, 111-115. Google Scholar38. MOYNIHAN BG: A case of complete gastrectomy, Lancet, 1911, ii, 430-431. CrossrefGoogle Scholar39. HARTMAN HR: Blood changes in a gastrectomized patient simulating those of pernicious anemia, Am. Jr. Med. Sci., 1921, clxii, 201-206. CrossrefGoogle Scholar40. UNGLEY CC: The stomach and pernicious anemia, Newcastle Med. Jr., 1929, x, 14-39. Google Scholar41. DENNIG H: Perniziöse Anämie nach Magenresektion, München. med. Wchnschr., 1929, lxxvi, 633. Google Scholar42. WALTERS W: Total gastrectomy for carcinoma; physiologic and chemical studies during period of two years following operation, Jr. Am. Med. Assoc., 1933, c, 804-806. CrossrefGoogle Scholar43. IVYMORGANFARRELL ACJEJI: The effects of total gastrectomy; experimental achylia gastrica in dogs with occurrence of spontaneous anemia, Surg., Gynec. and Obst., 1931, xliii, 611-620. Google Scholar44. NEUSSER H: Zur Klinik der perniciösen Anämie, Wien. klin. Wchnschr., 1899, xii, 388-395. Google Scholar45. STRAUSS H: Untersuchungen über die Resorption und den Stoffwechsel bei "Apepsia gastrica" mit besonderer Berücksichtigung der perniciösen Anämie, Ztschr. f. klin. Med., 1900, xli, 280-320. Google Scholar46. GRIFFITHS WJ: The action of gastric juice on beef muscle-globulin, with reference to anemia, Biochem. Jr., 1934, xxviii, 671-675. CrossrefGoogle Scholar47. MALTBY EJ: The digestion of beef proteins in the human stomach, Jr. Clin. Invest., 1934, xiii, 193-207. CrossrefGoogle Scholar48. HURST AF: Achlorhydria and achylia gastrica and their connection with Addison's anemia—subacute combined degeneration syndrome and simple (non-Addisonian) achlorhydric anemia, Quart. Jr. Med., 1932, i, 157-177. Google Scholar49. DAVIDSON S: The etiology of pernicious anemia. A review of the factors concerned in its production, Edinburgh Med. Jr., 1928, xxxv, 322-343. Google Scholar50. HURST AF: The unity of gastric disorders, Alvarez lecture, Trans. Am. Gastro-Entero. Assoc., 1933, 70-85. Google Scholar51. WATKINS CH: Classification of chronic idiopathic secondary anemia with special reference to morphology of blood, Jr. Am. Med. Assoc., 1929, xciii, 1365-1367. CrossrefGoogle Scholar52. WITTS LJ: Simple achlorhydric anemia, Guy's Hosp. Rep., 1930, lxxx, 253-296. Google Scholar53. WAUGH TR: Idiopathic hypochromemia, Am. Jr. Med. Sci., 1931, clxxxii, 554-565. Google Scholar54. DAMESHEK W: Primary hypochromic anemia (erythro-normoblastic anemia); new type of idiopathic anemia, Am. Jr. Med. Sci., 1931, clxxxii, 520-553. CrossrefGoogle Scholar55. VANDERHOOFDAVIS DD: Anemia of the microcytic type in middle-aged women, Am. Jr. Med. Sci., 1932, clxxxiv, 29-33. CrossrefGoogle Scholar56. WINTROBEBEEBE HMRT: Idiopathic hypochromic anemia, Medicine, 1933, xii, 187-243. CrossrefGoogle Scholar57. MEULENGRACHT E: Simple achylic anemia, Acta. med. Scandinav., 1932, lxxviii, 387-426. Google Scholar58. WITTSDAVIESMACKAY LJDTHM: Discussion on the therapeutic uses of iron, Proc. Roy. Soc. Med. (Sect. Therap. and Pharm.), 1931, xxiv, 7-24. Google Scholar59. BLOOMFIELD AL: The relations between primary hypochromic anemia and chlorosis, Arch. Int. Med., 1932, l, 328-337. CrossrefGoogle Scholar60. SCHULTEN H: The treatment of hypochromic anemia with large doses of iron, München, med. Wchnschr., 1930, lxxvii, 355-356. Google Scholar61. METTIERMINOT SRGR: Effect of iron on blood formation as influenced by changing acidity of gastro-duodenal contents in certain cases of anemia, Am. Jr. Med. Sci., 1931, clxxxi, 25-36. CrossrefGoogle Scholar62. HEATH CW: The interrelation of pernicious anemia and idiopathic hypochromic anemia. Study of family in which both conditions occurred singly and combined, Am. Jr. Med. Sci., 1933, clxxxv, 365-381. CrossrefGoogle Scholar63. STRAUSSCASTLE MBWB: Studies of anemia in pregnancy; etiologic relationship of gastric secretory defects and dietary deficiency to hypochromic and macrocytic (pernicious) anemias of pregnancy and treatment of these conditions, Am. Jr. Med. Sci., 1933, clxxxv, 539-551. Google Scholar64. WHIPPLEROBSCHEIT-ROBBINS GHFS: Blood regeneration in severe anemia. I. Standard basal ration bread and experimental methods, Am. Jr. Physiol., 1925, lxxii, 395-407. CrossrefGoogle Scholar65. ROBSCHEIT-ROBBINSWHIPPLE FSGH: Blood regeneration in severe anemia. II. Favorable influence of liver, heart and skeletal muscle in diet, Am. Jr. Physiol., 1925, lxxii, 408-418. CrossrefGoogle Scholar66. MINOTMURPHY GRWP: Treatment of pernicious anemia by a special diet, Jr. Am. Med. Assoc., 1926, lxxxvii, 470-476. CrossrefGoogle Scholar67. MURPHYMINOT WPGR: A special diet for patients with pernicious anemia, Boston Med. and Surg. Jr., 1926, cxcv, 410-411. CrossrefGoogle Scholar68. COHNMINOTFULTONULRICHSSARGENTWEAREMURPHY EJGRJFHFFCJHWP: Nature of the material in liver effective in pernicious anemia, Proc. Am. Soc. Biol. Chem., Jr. Biol. Chem., 1927, lxxiv, p. lxix. Google Scholar69. MCCANN WS: Effect of kidney on blood regeneration in pernicious anemia, Proc. Soc. Exper. Biol. and Med. 1928, xxv, 255-258. CrossrefGoogle Scholar70. STURGISISAACS CCR: Desiccated stomach in the treatment of pernicious anemia, Jr. Am. Med. Assoc., 1929, xciii, 747-749. CrossrefGoogle Scholar71. MINOTMURPHYSTETSON GRWPRP: Response of reticulocytes to liver therapy; particularly in pernicious anemia, Am. Jr. Med. Sci., 1928, clxxv, 581-599. CrossrefGoogle Scholar72. COHNMINOTALLESSALTER EJGRGAWT: Nature of the material in liver effective in pernicious anemia, Jr. Biol. Chem., 1928, lxxvii, 325-358. CrossrefGoogle Scholar73. COHNMCMEEKINMINOT EJTLGR: The nature of the material effective in pernicious anemia, Proc. Am. Soc. Biol. Chem., Jr. Biol. Chem., 1930, lxxxvii, p. xlix-lii. Google Scholar74. ISAACSGOLDHAMER RSM: Rôle of decreased amount of gastric secretion in production of pernicious anemia, Proc. Soc. Exper. Biol. and Med., 1934, xxxi, 706-707. CrossrefGoogle Scholar75. BARNETT CW: The significance of the gastric secretion in pernicious anemia, Am. Jr. Med. Sci., 1932, clxxxiv, 24-28. CrossrefGoogle Scholar76. CASTLEHEATHSTRAUSSTOWNSEND WBCWMBWC: The relationship of disorders of the digestive tract to anemia, Jr. Am. Med. Assoc., 1931, xcvii, 904-907. CrossrefGoogle Scholar77. RICHTERIVYKIM OACMS: Action of human "pernicious anemia liver extract," Proc. Soc. Exper. Biol. and Med., 1932, xxix, 1093-1098. CrossrefGoogle Scholar78. WILKINSONKLEIN JFL: The hemopoietic activity of normal and abnormal human liver with especial reference to pernicious anemia, Quart. Jr. Med., 1934, iii, 341-359. Google Scholar79. GOLDHAMERISAACSSTURGIS SMRCC: The rôle of the liver in hematopoiesis, Am. Jr. Med. Sci., 1934, clxxxviii, 193-199. CrossrefGoogle Scholar80. GOLDHAMER SM: Liver extract therapy in cirrhosis of liver; relation of liver dysfunction to nonstorage of "anti-anemic" substance in producing blood picture resembling pernicious anemia in patient secreting free hydrochloric acid, Arch. Int. Med., 1934, liii, 54-57. CrossrefGoogle Scholar81. MINOTCOHNMURPHYLAWSON GREJWPHA: Treatment of pernicious anemia with liver extract. Effects upon the production of immature and mature red blood cells, Am. Jr. Med. Sci., 1928, clxxv, 599-622. CrossrefGoogle Scholar82. COHNMCKEEKINMINOT EJTLGR: Nature of the material effective in pernicious anemia, Am. Jr. Physiol., 1929, xc, 316-317. Google Scholar83. GÄUSSLEN M: Ein hockwirksamer, injizierbar Leberextract, Klin. Wchnschr., 1930, ix, 2099-2106. CrossrefGoogle Scholar84. SCHOTTMÜLLER H: Weitere Erfahrungen über die Lebertherapie bei Anaemia perniciosa, München. med. Wchnschr., 1931, lxxviii, 432. Google Scholar85. CASTLETAYLOR WBFH: Intravenous use of extract of liver. Maximal responses of reticulocytes from single injection derived from 100 grams of liver; preliminary communication, Jr. Am. Med. Assoc., 1931, xcvi, 1198-1201. CrossrefGoogle Scholar86. STRAUSSCASTLETAYLOR MBWBFH: Intramuscular use of liver extract; maximal responses of reticulocytes from daily intramuscular injection of extract derived from 10 grams of liver; preliminary communication, Jr. Am. Med. Assoc., 1931, xcvii, 313-314. CrossrefGoogle Scholar87. WILKINSON JF: Injections of highly purified liver preparations in pernicious anemia, Lancet, 1931, ii, 791-792. CrossrefGoogle Scholar88. ZERFAS LG: Liver extract for pernicious anemia; blood changes during first month; report of 101 cases, Int. Med., 1931, xlvii, 135-143. Google Scholar89. RIDDLESTURGIS MCCC: The effect of single massive doses of liver extract on patients with pernicious anemia, Am. Jr. Med. Sci., 1930, clxxx, 1-11. CrossrefGoogle Scholar90. MURPHY WP: Parenteral use of liver extract in pernicious anemia, Jr. Am. Med. Assoc., 1932, xcviii, 1051-1060. CrossrefGoogle Scholar91. CONNERYGOLDWATER JELJ: Parenteral use of liver extract in the treatment of pernicious anemia, Jr. Am. Med. Assoc., 1932, xcviii, 1060-1067. CrossrefGoogle Scholar92. ISAACSSTURGISGOLDHAMERBETHELL RCCSMFH: The use of liver extract intravenously in the treatment of pernicious anemia, Jr. Am. Med. Assoc., 1933, c, 629-633. CrossrefGoogle Scholar93. REIMANN F: Versuche zur Potenzierung der Wirkung oral verabreichter Leber. Kurze wissenschaftliche Mitteilung, Med. Klin., 1931, xxvii, 880-881. Google Scholar94. WALDENCLOWES GBGH: Pernicious anemia: method whereby therapeutic efficacy of liver and liver fractions may be substantially increased, Proc. Soc. Exper. Biol. and Med., 1932, xxix, 873-875. CrossrefGoogle Scholar95. FOUTSZERFAS PJLG: Liver-gastric tissue preparations in the treatment of pernicious anemia, Jr. Am. Med. Assoc., 1933, ci, 188-192. CrossrefGoogle Scholar96. HELMERFOUTSZERFAS OMPJLG: Increased potency of liver extract by incubation with human gastric juice, Proc. Soc. Exper. Biol. and Med., 1933, xxx, 775-778. CrossrefGoogle Scholar97. HERRONMCELLROY WFWS: The use of autolyzed liver in the treatment of pernicious anemia; preliminary clinical report, Jr. Am. Med. Assoc., 1933, c, 1084-1086. CrossrefGoogle Scholar98. HERRONMCELLROY WFWS: Use of autolyzed liver in anemia and other conditions, Penn. Med. Jr., 1934, xxxvii, 406-408. Google Scholar99. MORRISSCHIFFFOULGERRICHSHERMAN RSLJHMLJE: Observations on hematopoietic hormone (addisin) in pernicious anemia, Brit. Med. Jr., 1932, ii, 1050-1051. CrossrefGoogle Scholar100. MORRISSCHIFFFOULGERRICHSHERMAN RSLJHMLJE: The treatment of pernicious anemia; effect of single injection of concentrated gastric juice (addisin), Jr. Am. Med. Assoc., 1933, c, 171-173. CrossrefGoogle Scholar101. CONNER HM: Increase of reticulated erythrocytes in pernicious anemia following intramuscular injection of gastric juice, Proc. Staff Meet., Mayo Clinic, 1932, vii, 213-216. Google Scholar102. WILKINSON JF: Hematopoietic hormone in pernicious anemia, Brit. Med. Jr., 1932, ii, 1163. CrossrefGoogle Scholar103. FOUTSHELMERZERFAS PJOMLG: Formation of a hematopoietic substance in concentrated gastric juice, Am. Jr. Med. Sci., 1934, clxxxvii, 36-49. CrossrefGoogle Scholar104. MINOT GR: The interpretation of reticulocyte responses in pernicious anemia, Trans. Assoc. Am. Physicians, 1934. (In print.) Google Scholar105. HELMERFOUTSZERFAS OMPJLG: The relationship of the intrinsic factor to a hematopoietic material in concentrated human gastric juice, Am. Jr. Med. Sci., 1934, clxxxviii, 184-193. CrossrefGoogle Scholar106. MORRISSCHIFFFOULGERRICH RSLJHML: Further studies on addisin in diseases of the blood, Trans. Assoc. Am. Physicians, 1933, xlviii, 298-304. Google Scholar107. KRUSEMCCOLLUM HDEV: Review of recent studies on the antineuritic vitamin; its chemical and physiologic properties, and the effects of its deprivation on the animal body, Jr. Am. Med. Assoc., 1932, xcviii, 2201-2208. CrossrefGoogle Scholar108. DANYSZKOSKOWSKI MW: Étude de quelques fonctions digestives chez les pigeons normaux nourris au riz poli et en inanition, Compt. rend. Acad. d. sc., 1922, clxxv, 54-56. Google Scholar109. FARNUM MB: Gastric secretion in experimental beri-beri in dog, Arch. Int. Med., 1926, xxxvii, 212-216. CrossrefGoogle Scholar110. COWGILLGILMAN GRA: Physiology of vitamins. The effect of lack of the vitamin B complex on the secretion of gastric juice in dogs with gastric pouches, Arch. Int. Med., 1934, liii, 58-70. CrossrefGoogle Scholar111. WEBSTERARMOUR DRJC: Effect of vitamin B deficiency on gastric secretion, Proc. Soc. Exper. Biol. and Med., 1933, xxx, 1297-1300. CrossrefGoogle Scholar112. WEBSTERARMOUR DRJC: Vitamin B complex and gastric secretion, Proc. Soc. Exper. Biol. and Med., 1934, xxxi, 463-464. CrossrefGoogle Scholar113. MILLERRHOADES DKCP: Production in dogs of a syndrome similar to sprue by diets deficient in vitamin B2 , Proc. Soc. Exper. Biol. and Med., 1933, xxx, 540-541. CrossrefGoogle Scholar114. MUSSER JH: Internal medicine, 1932, Lea and Febiger, Philadelphia. Google Scholar115. LEWIS GE: The smooth tongue—a study in deficiency disease, Practitioner, 1930, cxxv, 749-755. Google Scholar116. HUTTERMIDDLETON AMWS: Vitamin B deficiency and the atrophic tongue, Jr. Am. Med. Assoc., 1933, ci, 1305-1308. CrossrefGoogle Scholar117. GUHA BC: The vitamin B2 potency of commercial liver extract, Lancet, 1931, i, 864-865. CrossrefGoogle Scholar118. GILROY E: Vitamin B content of commercial liver extracts and stomach preparations, Lancet, 1931, ii, 1093-1098. CrossrefGoogle Scholar119. WEST R STRAUSSCASTLE MBWB; Communication to : Nature of extrinsic factor of deficiency state in pernicious anemia and in related macrocytic anemias; activation of yeast derivatives with normal gastric juice, N. Eng. Jr. Med., 1932, ccvii, 55-59. Google Scholar120. COWGILL GR: Liver Extract 343 N. N. R. is rich in vitamin B2. (Personal communication.) Google Scholar121. WILLS L: Treatment of "pernicious anemia of pregnancy" and "tropical anemia," with special reference to yeast extract as curative agent, Brit. Med. Jr., 1931, i, 1059-1064. CrossrefGoogle Scholar122. VAUGHANHUNTER JMD: The treatment by marmite of megalocytic hyperchromic anemia occurring in idiopathic steatorrhea (celiac disease), Lancet, 1932, i, 829-834. CrossrefGoogle Scholar123. CASTLERHOADES WBCP: Etiology and treatment of sprue in Porto Rico, Lancet, 1932, i, 1198-1199. CrossrefGoogle Scholar124. GOODAL A: The treatment of pernicious anemia by marmite, Lancet, 1932, ii, 781-782. CrossrefGoogle Scholar125. UNGLEY CC: Marmite in pernicious anemia, Lancet, 1932, ii, 867. Google Scholar126. DAVIDSON S: Marmite in pernicious anemia, Lancet, 1932, ii, 919-920. CrossrefGoogle Scholar127. CONNERYGOLDWATER JELJ: Pernicious anemia, a conditioned deficiency; observations on effect of administration of substance rich in vitamin B complex, N. England Jr. Med., 1933, ccix, 446-450. CrossrefGoogle Scholar128. RUSSELL HK: Hematological response of Addisonian pernicious anemia to brewer's yeast, ANN. INT. MED., 1934, vii, 1398-1402. Google Scholar129. LASSENLASSEN HCHK: Yeast or vitamin B2 as "extrinsic factor" in treatment of pernicious anemia, Am. Jr. Med. Sci., 1934, clxxxviii, 461-472. CrossrefGoogle Scholar130. DAVIDSON S: Vitamin B in anemia, Lancet, 1931, ii, 1395-1398. CrossrefGoogle Scholar131. BLOCKCOWGILLKLOTZ RJGRBH: The antineuritic vitamin; method of assay, concentration of vitamin with silver under various conditions, and its solubility in certain organic solvents, Jr. Biol. Chem., 1932, xciv, 765-782. CrossrefGoogle Scholar132. WILLS L: The nature of the hematopoietic factor in marmite, Lancet, 1932, i, 1283-1286. Google Scholar133. CHICKCOPPING HAM: Heat stability of (anti-dermatitis, "anti-pellagra") water soluble vitamin B2 , Biochem. Jr., 1930, xxiv, 932-938. CrossrefGoogle Scholar134. WILLSNAISH LA: A case of pernicious anemia treated with vitamin B2 from egg-white, Lancet, 1933, i, 1286. CrossrefGoogle Scholar135. LASSENLASSEN HCHKEditor's footnote to article by : Yeast or vitamin B2 as "extrinsic factor" in treatment of pernicious anemia, Am. Jr. Med. Sci., 1934, clxxxviii, 461-472. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 16, 1934.From the Department of Internal Medicine, Yale University, School of Medicine, New Haven. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE LIPID AND MINERAL DISTRIBUTION OF THE SERUM AND ERYTHROCYTES IN PERNICIOUS ANEMIAThe chemical nature of the anti-anemic principle 1 March 1935Volume 8, Issue 9Page: 991-1007KeywordsHematopoiesisNervous systemStomachSweat ePublished: 1 December 2008 Issue Published: 1 March 1935 PDF downloadLoading ...