tbuckley/cabot-search huggingface dataset:
Evaluating Supplemental Breast Cancer Screening With Simulation Modeling
Authors: Ilana B. Richman, Tracy A. Battaglia
Journal: JAMA Internal Medicine (2024)

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Methodological Considerations for Difference-in-Differences
Authors: Alyssa Bilinski, Ishani Ganguli
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Reevaluating Piperacillin-Tazobactam Mortality
Authors: Chia-Ter Chao
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Prioritizing Data Privacy and Security in Pediatric AI
Authors: Yanyi Wu, Chenghua Lin
Journal: JAMA Pediatrics (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Physician EHR Time and Visit Volume Following Adoption of Team-Based Documentation Support
Authors: Nate C. Apathy, A. Jay Holmgren, Dori A. Cross
Journal: JAMA Internal Medicine (2024)

Physicians spend the plurality of active electronic health record (EHR) time on documentation. Excessive documentation limits time spent with patients and is associated with burnout. Organizations need effective strategies to reduce physician documentation burden; however, evidence on team-based documentation (eg, medical scribes) has been limited to small, single-institution studies lacking rigorous estimates of how documentation support changes EHR time and visit volume.
Single-cell dissection of the human blood-brain barrier and glioma blood-tumor barrier
Authors: Yuan Xie, Fan Yang, Liqun He, Hua Huang, Min Chao, Haiyan Cao, Yaqin Hu, Zhicheng Fan, Yaohong Zhai, Wenjian Zhao, Xian Liu, Ruozhu Zhao, Bing Xiao, Xinxin Shi, Yuancheng Luo, Jinlong Yin, Dayun Feng, Jean-Philippe Hugnot, Lars Muhl, Anna Dimberg, Christer Betsholtz, Yanyu Zhang, Liang Wang, Lei Zhang
Journal: Neuron (2024)
Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes
Authors: Rohan Khera, Arya Aminorroaya, Lovedeep Singh Dhingra, Phyllis M Thangaraj, Aline Pedroso Camargos, Fan Bu, Xiyu Ding, Akihiko Nishimura, Tara V Anand, Faaizah Arshad, Clair Blacketer, Yi Chai, Shounak Chattopadhyay, Michael Cook, David A Dorr, Talita Duarte-Salles, Scott L DuVall, Thomas Falconer, Tina E French, Elizabeth E Hanchrow, Guneet Kaur, Wallis C Y Lau, Jing Li, Kelly Li, Yuntian Liu, Yuan Lu, Kenneth K C Man, Michael E Matheny, Nestoras Mathioudakis, Jody-Ann McLeggon, Michael F McLemore, Evan Minty, Daniel R Morales, Paul Nagy, Anna Ostropolets, Andrea Pistillo, Thanh-Phuc Phan, Nicole Pratt, Carlen Reyes, Lauren Richter, Joseph S Ross, Elise Ruan, Sarah L Seager, Katherine R Simon, Benjamin Viernes, Jianxiao Yang, Can Yin, Seng Chan You, Jin J Zhou, Patrick B Ryan, Martijn J Schuemie, Harlan M Krumholz, George Hripcsak, Marc A Suchard
Journal: Journal of the American College of Cardiology (2024)
Antithrombotic Strategies for Patients With Peripheral Artery Disease
Authors: Marc P Bonaca, Geoffrey D Barnes, Rupert Bauersachs, Youssef Bessada, Michael S Conte, Anahita Dua, Connie N Hess, Maya Serhal, Carlos Mena-Hurtado, Jeffrey I Weitz, Joshua A Beckman
Journal: Journal of the American College of Cardiology (2024)
Antithrombotic Strategies in Atrial Fibrillation After ACS and/or PCI
Authors: Otavio Berwanger, Daniel M Wojdyla, Alexander C Fanaroff, Andrzej Budaj, Christopher B Granger, Roxana Mehran, Ronald Aronson, Stephan Windecker, Shaun G Goodman, John H Alexander, Renato D Lopes
Journal: Journal of the American College of Cardiology (2024)
Epidemiologic Analysis of a Postelimination Measles Outbreak in Central Ohio, 2022-2023
Authors: Rosemary A. Martoma, Matthew Washam, Hinda Omar, Ava R. Martoma, Randal De Souza, Sagar Kumar, Robert D. Sege, Emily E. Ricotta, Maimuna S. Majumder
Journal: JAMA Network Open (2024)

Importance Postelimination outbreaks threaten nearly a quarter century of measles elimination in the US. Understanding these dynamics is essential for maintaining the nation’s measles elimination status. Objective To examine the demographic characteristics and transmission dynamics of the 2022 to 2023 central Ohio measles outbreak. Design, Setting, and Participants This cross-sectional study used electronic medical records and publicly available measles reports within an extensive central Ohio primary care network involving inpatient and outpatient settings. Participants included 90 children in Ohio with confirmed measles cases in 2022. Exposure The exposure of interest was confirmed measles cases in Ohio in 2022. This included 5 internationally imported cases and 85 locally acquired cases. Main Outcomes and Measures The primary outcome involved documenting and analyzing confirmed measles cases in Ohio in 2022, focusing on demographic characteristics, immunization status, and transmission links in outbreak-related cases. Results This study analyzed 90 measles cases (47 [52.2%] male participants) in Ohio during 2022. Most participants self-identified as African or American Black (72 [80.0%]), with additional race categories including Asian, Hispanic, multirace (6 [6.7%]), White, and unknown (6 [6.7%]). Most participants were of Somali descent (64 [71.1%]), with additional ethnicity categories including American (16 [17.8%]), Guatemalan, Nepali, and unknown (6 [6.7%]). Participants were predominantly younger than 6 years (86 [95.5%]), unimmunized (89 [98.9%]), and resided in Franklin County, Ohio (83 [92.2%]). Prior to November 20, 2022, all cases occurred among unimmunized children of Somali descent in the Columbus area. Nosocomial superspreading events expanded the outbreak beyond the initially affected community. Conclusions and Relevance This cross-sectional study of measles cases in Ohio during 2022 found that the outbreak primarily affected unimmunized children of Somali descent, highlighting the necessity for culturally tailored public health strategies to maintain measles elimination in the US. These findings underscore the importance of implementing targeted interventions and enhancing community engagement to increase vaccination rates.
Anticoagulation Alone vs Anticoagulation Plus Aspirin or DAPT Following Left Atrial Appendage Occlusion
Authors: Samuel W. Reinhardt, Douglas N. Gibson, Jonathan C. Hsu, Samir R. Kapadia, Robert W. Yeh, Matthew J. Price, Jonathan P. Piccini, Devi G. Nair, Thomas Christen, Dominic J. Allocco, James V. Freeman
Journal: Journal of the American College of Cardiology (2024)
Reevaluating Piperacillin-Tazobactam Mortality
Authors: Chi-Kuei Hsu, Chih-Cheng Lai
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
An interpretable multimodal model based on cytology ultrasound noninvasively predicts lymph node metastasis in cN0 papillary thyroid cancer:a retrospective, ulticentre study
Authors: Xiachuan Qin, Weihan Xiao, Wang Zhou, Junli Wang, Xianjun Ye, Tiantian Ren, Liang Zong, Xiaoling Xiu, Qiongxian Long, Hongmei Yuan, Junjie Zhao, Yanting Wen, Xiaoguang Guo, Fanding He, Chaoxue Zhang
Journal: International Journal of Surgery (2024)

Qin, Xiachuan; Xiao, Weihan; Zhou, Wang; Wang, Junli; Ye, Xianjun; Ren, Tiantian; Zong, Liang; Xiu, Xiaoling; Long, Qiongxian; Yuan, Hongmei; Zhao, Junjie; Wen, Yanting; Guo, Xiaoguang; He, Fanding; Zhang, Chaoxue Author Information
Chromothripsis-Mediated Small Cell Lung Carcinoma
Authors: Natasha Rekhtman, Sam E. Tischfield, Christopher A. Febres-Aldana, Jake June-Koo Lee, Jason C. Chang, Benjamin O. Herzberg, Pier Selenica, Hyung Jun Woo, Chad M. Vanderbilt, Soo-Ryum Yang, Fei Xu, Anita S. Bowman, Edaise M. da Silva, Anne Marie Noronha, Diana L. Mandelker, Miika Mehine, Semanti Mukherjee, Juan Blanco-Heredia, John J. Orgera, Gouri J. Nanjangud, Marina K. Baine, Rania G. Aly, Jennifer L. Sauter, William D. Travis, Omid Savari, Andre L. Moreira, Christina J. Falcon, Francis M. Bodd, Christina E. Wilson, Jacklynn V. Sienty, Parvathy Manoj, Harsha Sridhar, Lu Wang, Noura J. Choudhury, Michael Offin, Helena A. Yu, Alvaro Quintanal-Villalonga, Michael F. Berger, Marc Ladanyi, Mark T.A. Donoghue, Jorge S. Reis-Filho, Charles M. Rudin
Journal: Cancer Discovery (2024)

Abstract Small cell lung carcinoma (SCLC) is a highly aggressive malignancy that is typically associated with tobacco exposure and inactivation of RB1 and TP53 genes. Here, we performed detailed clinicopathologic, genomic, and transcriptomic profiling of an atypical subset of SCLC that lacked RB1 and TP53 co-inactivation and arose in never/light smokers. We found that most cases were associated with chromothripsis—massive, localized chromosome shattering—recurrently involving chromosome 11 or 12 and resulting in extrachromosomal amplification of CCND1 or co-amplification of CCND2/CDK4/MDM2, respectively. Uniquely, these clinically aggressive tumors exhibited genomic and pathologic links to pulmonary carcinoids, suggesting a previously uncharacterized mode of SCLC pathogenesis via transformation from lower-grade neuroendocrine tumors or their progenitors. Conversely, SCLC in never-smokers harboring inactivated RB1 and TP53 exhibited hallmarks of adenocarcinoma-to-SCLC derivation, supporting two distinct pathways of plasticity-mediated pathogenesis of SCLC in never-smokers. Significance: Here, we provide the first detailed description of a unique SCLC subset lacking RB1/TP53 alterations and identify extensive chromothripsis and pathogenetic links to pulmonary carcinoids as its hallmark features. This work defines atypical SCLC as a novel entity among lung cancers, highlighting its exceptional histogenesis, clinicopathologic characteristics, and therapeutic vulnerabilities. See related commentary by Nadeem and Drapkin, p. 8
Outcomes Following Surgical and Nonsurgical Treatment for Uncomplicated Appendicitis in Older Adults
Authors: Matthew Ashbrook, Maggie McGing, Vincent Cheng, Morgan Schellenberg, Matthew Martin, Kenji Inaba, Kazuhide Matsushima
Journal: JAMA Network Open (2024)

Importance The optimal treatment of acute uncomplicated appendicitis in older adults with frailty is not defined. Objective To examine outcomes associated with treatment strategies for acute uncomplicated appendicitis in older adults with or without frailty. Design, Setting, and Participants This retrospective cohort study used National Inpatient Sample data from adults 65 years or older with a diagnosis of uncomplicated appendicitis from January 1, 2016, to December 31, 2018. Data were analyzed from July to November 2023. The National Inpatient Sample database approximates a 20% stratified sample of all inpatient hospital discharges in the US. Exposures Study patients were categorized into 3 groups: nonoperative management, immediate operation, and delayed operation. Main Outcomes and Measures Clinical outcomes, including hospital complications and in-hospital mortality, were assessed among older adults with and without frailty, identified using an adapted claims-based frailty index. Results A total of 24 320 patients were identified (median [IQR] age, 72 [68-79] years; 50.9% female). Of those, 7290 (30.0%) were categorized as having frailty. Overall, in-hospital mortality was 1.4%, and the incidence of complications was 37.3%. In patients with frailty, multivariable analysis showed both nonoperative management (odds ratio [OR], 2.89; 95% CI, 1.40-5.98; P &amp;amp;lt; .001) and delayed appendectomy (OR, 3.80; 95% CI, 1.72-8.43; P &amp;amp;lt; .001) were associated with increased in-hospital mortality compared with immediate appendectomy. In patients without frailty, immediate appendectomy was associated with increased hospital complications compared with nonoperative management (OR, 0.77; 95% CI, 0.64-0.94; P = .009) and lower hospital complications compared with delayed appendectomy (OR, 2.05; 95% CI, 1.41-3.00; P &amp;amp;lt; .001). Conclusions and Relevance In this cohort study of older adults with uncomplicated appendicitis, outcomes differed among management strategies based on frailty status. Routine frailty assessments incorporated in the care of older adult patients may help guide discussions for shared decision-making.
Lay-Led Intervention for War and Refugee Trauma
Authors: Lori A. Zoellner, Jacob A. Bentley, Kawther Musa, Farhiya Mohamed, Luul B. Ahmed, Kevin M. King, Norah C. Feeny, Hana Ali, Yasmin Ibrahim, Abdi Ismail, Safiya Omar, Mohamed Roble, Warsame Roble, Nafiso Samatar, Mohammed Alsubaie, Michael Dolezal, Alexandra Klein, Emma PeConga, Peter Rosencrans, Rosemary Walker, Alexandra Bowling, Ashleigh Holloway, Ifrah Sheikh, Eesha Ali
Journal: JAMA Network Open (2024)

The global refugee crisis disproportionately affects the Muslim world. Forced displacement often results in trauma-related mental health issues. Effective psychotherapy exists, but there are barriers to uptake by refugee groups as well as a lack of culturally appropriate interventions.
Serine and glycine physiology reversibly modulate retinal and peripheral nerve function
Authors: Esther W Lim, Regis J Fallon, Caleb Bates, Yoichiro Ideguchi, Takayuki Nagasaki, Michal K Handzlik, Emeline Joulia, Roberto Bonelli, Courtney R Green, Brendan R E Ansell, Maki Kitano, Ilham Polis, Amanda J Roberts, Shigeki Furuya, Rando Allikmets, Martina Wallace, Martin Friedlander, Christian M Metallo, Marin L Gantner
Journal: Cell Metabolism (2024)

Metabolic homeostasis is maintained by redundant pathways to ensure adequate nutrient supply during fasting and other stresses. These pathways are regulated locally in tissues and systemically via the liver, kidney, and circulation. Here, we characterize how serine, glycine, and one-carbon (SGOC) metabolism fluxes across the eye, liver, and kidney sustain retinal amino acid levels and function. Individuals with macular telangiectasia (MacTel), an age-related retinal disease with reduced circulating serine and glycine, carrying deleterious alleles in SGOC metabolic enzymes exhibit an exaggerated reduction in circulating serine. A Phgdh
<i>APOL1</i> Variant and Kidney Disease
Authors: Constance B. Hilliard
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reevaluating Piperacillin-Tazobactam Mortality—Reply
Authors: Rishi Chanderraj, Robert P. Dickson, Michael W. Sjoding
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Symptoms of Depression, Eating Disorders, and Binge Eating in Adolescents With Obesity
Authors: Hiba Jebeile, Louise A. Baur, Cathy Kwok, Shirley Alexander, Justin Brown, Clare E. Collins, Christopher T. Cowell, Kaitlin Day, Sarah P. Garnett, Megan L. Gow, Alicia M. Grunseit, Maddison Henderson, Eve T. House, Mary-Kate Inkster, Sarah Lang, Susan J. Paxton, Helen Truby, Krista A. Varady, Natalie B. Lister
Journal: JAMA Pediatrics (2024)

Depression and eating disorders are heightened for adolescents with obesity. Clinical reviews alongside self-report questionnaires are important to ensure appropriate intervention.
Culturally Aware Vaccine Promotion to Prevent Outbreaks
Authors: Sarah Schaffer DeRoo, Rupali J. Limaye
Journal: JAMA Network Open (2024)

Rosemary A. Martoma, MD, MBChB; Matthew Washam, MD, MPH; Hinda Omar; Ava R. Martoma; Randal De Souza, MD; Sagar Kumar, BS; Robert D. Sege, MD, PhD; Emily E. Ricotta, PhD, MSc; Maimuna S. Majumder, PhD