tbuckley/cabot-search huggingface dataset:
Construction of S100 family members prognosis prediction model and analysis of immune microenvironment landscape at single-cell level in pancreatic adenocarcinoma: a tumor marker prognostic study
Authors: Zi-jin Xu, Jian-ang Li, Ze-yuan Cao, Hua-xiang Xu, Ying Ying, Zhi-hang Xu, Run-jie Liu, Yuquan Guo, Zi-xin Zhang, Wen-quan Wang, Liang Liu
Journal: International Journal of Surgery (2024)

Pancreatic adenocarcinoma characterized by a mere 10% five-year survival rate, poses a formidable challenge due to its specific anatomical location, making tumor tissue acquisition difficult. This limitation underscores the critical need for novel biomarkers to stratify this patient population. Accordingly, this study aimed to construct a prognosis prediction model centered on S100 family members. Leveraging six S100 genes and their corresponding coefficients, an S100 score was calculated to predict survival outcomes. The present study provided comprehensive internal and external validation along with power evaluation results, substantiating the efficacy of the proposed model. Additionally, the study explored the S100-driven potential mechanisms underlying malignant progression. By comparing immune cell infiltration proportions in distinct patient groups with varying prognoses, the research identified differences driven by S100 expression. Furthermore, the analysis explored significant ligand-receptor pairs between malignant cells and immune cells influenced by S100 genes, uncovering crucial insights. Notably, the study identified a novel biomarker capable of predicting the sensitivity of neoadjuvant chemotherapy, offering promising avenues for further research and clinical application.
Accurate location describe and management of lymph node recurrence after esophagectomy for thoracic esophageal squamous cell carcinoma: a retrospective cohort study
Authors: Qian Zhao, Jinglong Sun, Feng Zheng, MD Dan Han, Chengrui Fu, Hongfu Sun, Chengxin Liu, Zhongtang Wang, Wei Huang, Ruozheng Wang, Baosheng Li
Journal: International Journal of Surgery (2024)

Background: Describe the accurate locations of lymph node recurrence LNR of Chinese patients with postoperative thoracic esophageal squamous cell carcinoma (ESCC) is essential for determining the need for further surveillance protocols and treatments. We aimed to evaluate the patterns of postoperative ESCC and its current risk stratification with LNR. Methods: This population-based cohort study included a retrospective review of the medical records and image material of patients with ESCC who underwent LNR after radical surgery between January 2013 and September 2022, with a median follow-up time of 5.71 years. Clinical features were extracted from these records, and survival analysis was performed. The primary endpoint was the accurate location and range of LNR according to the nomenclature of the Japanese Society for Esophageal Diseases. The second endpoints was to explore the related factors of recurrence range (RR) and overall survival (OS) . Results: A total of 3268 lymph node regions were recurrence from 1129 patients, with a mean of 2.89 regions per patient. No.104, 106 and 107 was the most common recurrence of thoracic ESCC with an LNR rate higher than 15%. In upper thoracic ESCC, No.105 was a common recurrence site and abdominal lymph node recurrence was rare. In lower thoracic ESCC, retroperitoneal lymph node was a unique regions (15.4%). Anastomotic recurrence is an important recurrence pattern in patients with postoperative esophageal cancer, with an incidence of 24.5%. Rates of lymph node recurrence in range of lymph node dissection was low (13.9%). The median time of LRT was 20.0 (1.5-184.0) months. High range of recurrence was associated with significantly poorer OS in patients. Multiple linear regression analysis identified demonstrated N stage, tumor differentiation, adjuvant radiotherapy and total lymph nodes removed were association with recurrence range for patients. Conclusions: Supraclavicular and upper mediastinums lymph nodes were common recurrence site for ESCC patients , and careful initial staging and surveillance are needed. Thorough lymph node dissection may reduce the range of regional recurrence.
A commentary on ‘Identification and initial validation of maximal tumor area as a novel prognostic factor for overall and disease-free survival in patients with resectable colon cancer: a retrospective study’
Authors: Lili Deng, Wei Cheng, Wen Liu
Journal: International Journal of Surgery (2024)

Department of Radiology, Jinshan Hospital, Fudan University, Shanghai 201508, China Lili Deng and Wei Cheng contributed equally to this work. Fund: Shanghai Municipal Commission of Health (ZK2019B01). Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address. E-mail address: [email protected] (W. Liu) This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Efficacy of hypothermic oxygenated machine perfusion in liver transplantation: a trial sequential analysis
Authors: I-Wen Chen, Wei-Ting Wang, Shu-Wei Liao, Kuo-Chuan Hung
Journal: International Journal of Surgery (2024)

Chen, I-Wen MD; Wang, Wei-Ting BSc; Liao, Shu-Wei MD; Hung, Kuo-Chuan MD Author Information
Global trends in colorectal cancer and metabolic syndrome research: a bibliometric and visualization analysis
Authors: Peng-Ning Wu, Jia-Li Liu, Mei-Juan Fang, Xiao-Shuo Fu, Jia-Li Wei, Yue Wang, Hai-Hua Qian, Dan Zhang
Journal: International Journal of Surgery (2024)

Numerous studies have demonstrated a robust correlation between metabolic syndrome (MetS) and colorectal cancer (CRC). Nonetheless, no systematic analysis or visualization of relevant publications has been conducted via bibliometrics. This research, centred on 616 publications obtainable through the Web of Science Core Collection (WoSCC), employed CiteSpace software and VOSviewer software for correlation analyses of authors, journals, institutions, countries, keywords, and citations. The findings indicate that the Public Library of Science had the highest number of publications, while the United States, China and South Korea were the most contributory nations. Recent years have seen the mechanisms linking Metabolic Syndrome with Colorectal Cancer, including diet, obesity, insulin resistance and intestinal flora, remain a burgeoning research area. Furthermore, bariatric surgery appears to be a promising new area of study. This paper presents the initial bibliometric and visualization analysis of research literature concerning CRC and MetS which examines research trends and hotspots.
Association of follow-up neutrophil-to-lymphocyte ratio and systemic inflammation response index with stroke-associated pneumonia and functional outcomes in cerebral hemorrhage patients: a case-controlled study
Authors: Mengmeng Xu, Jingru Wang, Chenyi Zhan, Ying Zhou, Zhixian Luo, Yunjun Yang, Dongqin Zhu
Journal: International Journal of Surgery (2024)

Background: Neutrophil-to-lymphocyte ratio (NLR) and systemic inflammation response index (SIRI) at admission are independent diagnostic biomarkers in stroke-associated pneumonia (SAP). Our study aimed to investigate the association between NLR, SIRI, specifically follow-up NLR and SIRI, and SAP, as well as their relationship with functional outcomes. Materials and Methods: We retrospectively included 451 consecutive ICH patients from May 2017 to May 2019. We conducted univariate and multivariable analyses to identify the factors independently associated with SAP and poor functional outcomes. Results: Compared to 127 (28.16%) patients diagnosed with SAP, those without SAP had both lower baseline and follow-up NLR and SIRI values ( P &lt;0.001). After adjustments, we found that baseline NLR (OR, 1.039 [95% CI, 1.003-1.077]; P =0.036) and follow-up NLR (OR, 1.054 [95% CI, 1.011-1.098]; P =0.012) were independently associated with SAP. The follow-up NLR was also associated with a higher mRS (OR, 1.124 [95% CI, 1.025-1.233]; P =0.013) and lower ADL-MBI score (OR, 1.167 [95% CI, 1.057-1.289]; P =0.002) at discharge. Multivariable analysis indicated that advanced age and nasogastric tube feeding were independently associated with SAP ( P &lt;0.05). We constructed a dynamic nomogram to identify SAP risk. Further subgroup analysis revealed that baseline NLR (OR, 1.062 [95% CI, 1.007-1.120]; P =0.026) is independently associated with SAP in the nasogastric feeding group, while follow-up NLR (OR, 1.080 [95% CI, 1.024-1.139]; P =0.005) was associated with the occurrence of SAP in non-nasogastric feeding patients. Conclusions: We found elevated baseline and follow-up NLR values were associated with SAP occurrence, and increasing follow-up NLR indicated poor functional outcomes. Inflammatory markers at different stages may offer individualized guidance for patients receiving various treatments.
A commentary on the article entitled ‘Finding the minimum number of retrieved lymph nodes in node-negative colorectal cancer using Real-world Data and the SEER database’
Authors: Yueyang Zhang, Zheng Xu, Haitao Zhou
Journal: International Journal of Surgery (2024)

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China Haitao Zhou This is the author to whom requests for reprints should be sent. Yueyang Zhang, Zheng Xu These authors contributed equally to this manuscript. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100021, China, Tel. +8613381167333. E-mail address: [email protected] (H. Zhou). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
A commentary on ‘Development and validation of a preoperative nomogram for predicting the surgical difficulty of laparoscopic colectomy for right colon cancer: a retrospective analysis’
Authors: Wei Cheng, Lili Deng, Wen Liu
Journal: International Journal of Surgery (2024)

Department of Radiology, Jinshan Hospital, Fudan University, Shanghai 201508, China Wei Cheng, Lili Deng Wei Cheng and Lili Deng contributed equally to this work Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: Jinshan Hospital, Fudan University, CHINA. E-mail address: [email protected] (W. Liu). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Complex causal association between genetically predicted 731 immunocyte phenotype and osteonecrosis: a bidirectional two-sample Mendelian randomization analysis
Authors: Wei Li, Jing-Wen Xu, Jin-Lian Chai, Cong-Cong Guo, Guang-Zheng Li, Mei Gao, Xue-Zhen Liang
Journal: International Journal of Surgery (2024)

Purpose: Previous studies have explored the role of immune cells on osteonecrosis. This Mendelian randomization (MR) study further assessed 731 immunocyte phenotypes on osteonecrosis whether a causal relationship exists and provides some evidence of causality. Methods: The 731 immunocyte phenotypes and osteonecrosis data used in this study were obtained from their respective genome-wide association studies (GWAS). We used inverse variable weighting (IVW) as the primary analysis method. In addition, we simultaneously employed multiple analytical methods, including MR-Egger, weighted mode, simple mode, and weighted median, to strengthen the final results. Finally, sensitivity analyses were conducted to verify the stability and feasibility of the data. Results: The results of the IVW method of MR analysis showed that 8 immunocyte phenotypes were positively associated with osteonecrosis ( P &lt;0.05, OR &gt; 1); 18 immunocyte phenotypes were negatively associated with osteonecrosis ( P &lt;0.05, OR&lt;1), none of which were heterogeneous or horizontally pleiotropic ( P &gt; 0.05) or reverse causality. In addition to this, in reverse MR, osteonecrosis was positively associated with 10 additional immunocyte phenotypes ( P &lt;0.05, OR &gt; 1) and negatively associated with 14 immunocyte phenotypes ( P &lt;0.05, OR&lt;1). And none of them had heterogeneity and horizontal pleiotropy ( P &gt; 0.05) or reverse causality. Conclusions: We demonstrated a complex causal relationship between multiple immune phenotypes and osteonecrosis through a comprehensive two-way two-sample MR analysis, highlighting the complex pattern of interactions between the immune system and osteonecrosis.
The obesity challenge in joint replacement: a multifaceted analysis of self-reported health status and exercise capacity using NHANES data: a population-based study
Authors: Xianzuo Zhang, Shen Xianyue, Bai Jiaxiang, Zang Wanli, Chen Mo, Abasi Maimaitiabula, Zhu Chen
Journal: International Journal of Surgery (2024)

Background: Joint replacement is successful for end-stage osteopathy, with obesity linked to evaluated risk. But the impact of obesity on self-reported health and exercise capacity among joint replacement patients remains complex and requires investigation. Methods: This study utilizes data from the National Health and Nutrition Examination Survey (NHANES) to examine the relationship between obesity severity, demographic factors, medical comorbidities, and self-reported health status. The relationship between general health status and BMI was analyzed using multivariable regression, and further illustrated using a restricted cubic spline. Additionally, a bibliometric analysis and systemic review was done to frame the research within the broader context of existing knowledge and demographic specifics. Results: Analysis of NHANES data involving 327 joint replacement patients yielded intriguing insights. The difference in self-reported health between BMI groups did not achieve conventional statistical significance ( P =0.06), and multivariable analysis showed that even severely obese patients did not exhibit significantly elevated risk of poor/fair self-reported health compared to normal weight subjects. Among severely obese individuals (BMI&gt;40), 40.63% still rated their health positively. However, stratified analyses indicated that obesity correlated with negative health reports across gender, age, and education strata. Notably, physical functioning emerged as a robust predictor of self-reported health, with those reporting no walking difficulties having significantly lower odds of poor/fair health (Odds Ratio=0.37, P =0.01). Conclusion: The study highlights the need for healthcare providers to consider individual physical abilities and comorbidities alongside obesity severity when discussing treatment options with joint replacement patients. It supports tailored interventions and informed shared decision-making. Future research could explore effective weight management strategies for obese individuals undergoing joint replacement.
Navigating the complex interplay between autophagy and hepatocellular carcinoma: a correspondence
Authors: Yan-Dong Miao, Liang Hao, Si-Xiang Lin
Journal: International Journal of Surgery (2024)

Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, Yantai 264100, China Yan-Dong Miao, Liang Hao These authors contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. *Corresponding author. Address: Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, Yantai 264100, China. E-mail address: [email protected] (S. X. Lin). *Corresponding author. Address: Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, Yantai 264100, China. E-mail address: [email protected] (Y. D. Miao). Supplemental Digital Content is available for this article. Direct URL citations are provided in the HTML and PDF versions of this article on the journal's website, www.lww.com/international-journal-of-surgery. Published online ■ ■ This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Increasing perioperative age and comorbidity: a 16-year cohort study at two University hospital sites in Sweden
Authors: Ellen Leigard, Daniel Hertzberg, David Konrad, Max Bell
Journal: International Journal of Surgery (2024)

Background: Increasing life expectancy affects all aspects of healthcare. During surgery elderly patients are prone to complications and have higher risk of death. We aimed to investigate if adult patients undergoing surgery at a large Swedish university hospital were getting older and sicker over time, and if this potential shift in age and illness severity was associated with higher patient mortality rates. Materials and methods: This was a 16-year cohort study on all surgical procedures performed in adult patients 2006-2021 at two sites of X University Hospital. Study data was obtained from the surgical system, electronic medical records and cause-of-death register. Information on age, sex, ASA-classification, date-, type-, acuity- and duration of surgery was collected. ICD-codes were used to calculate Charlson comorbidity index (CCI). Short-, medium- and long-term mortality rates were assessed. Logistic regression models were used to evaluate changes over time. Results: There were 622,814 surgical procedures 2006-2021. Age, ASA-classification and CCI increased over time ( P &lt;0.0001). The proportions of age ≥60 years increased from 41.8 to 52.8% and of ASA-class ≥3 from 22.5 to 47.6%. Comparing 2018-2021 with 2006-2009, odds ratios (95% confidence intervals) of 30-, 90- and 365-day mortality, adjusted for age, sex, non-elective surgery and ASA-classification, decreased significantly to 0.75 (0.71-0.79), 0.72 (0.69-0.76), and 0.76 (0.74-0.79), respectively. Conclusion: Although the surgical population got older and sicker during the 16-year study period, short-, medium- and long-term mortality rates decreased significantly. These demographic shifts must be taken into account when planning for future healthcare needs to preserve patient safety.
Prognostic value of tumor deposits and positive lymph node ratio in stage III colorectal cancer: a retrospective cohort study
Authors: Lei Liu, Jie Ji, Xianxiu Ge, Zuhong Ji, Jiacong Li, Jie Wu, Juntao Zhu, Jianan Yao, Fangyu Zhu, Boneng Mao, Zhihong Cao, Jinyi Zhou, Lin Miao, Guozhong Ji, Dong Hang
Journal: International Journal of Surgery (2024)

Background: In colorectal cancer (CRC), tumor deposits (TD) have been used to guide the N staging only in node-negative patients. It remains unknown about the prognostic value of TD in combination with positive lymph node ratio (LNR) in stage III CRC. Patients and methods: We analyzed data from 31,139 eligible patients diagnosed with stage III CRC, including 30,230 from the Surveillance, Epidemiology, and End Results (SEER) database as a training set and 909 from two Chinese hospitals as a validation set. The associations of TD and LNR with cancer-specific survival (CSS) and overall survival (OS) were evaluated using the Kaplan-Meier method and Cox regression models. Results: Both TD-positive and high LNR (value≥0.4) were associated with worse CSS in the training (multivariable hazard ratio [HR], 1.50; 95% confidence interval [CI], 1.43-1.58 and HR, 1.74; 95% CI, 1.62-1.86, respectively) and validation sets (HR,1.90; 95%CI, 1.41-2.54 and HR,2.01; 95%CI, 1.29-3.15, respectively). Compared to patients with TD-negative and low LNR (value&lt;0.4), those with TD-positive and high LNR had a 4.09-fold risk of CRC-specific death in the training set (HR, 4.09; 95% CI, 3.54-4.72) and 4.60-fold risk in the validation set (HR, 4.60; 95% CI, 2.88-7.35). Patients with TD-positive/H-LNR CRC on the right side had the worst prognosis ( P &lt;0.001). The combined variable of TD and LNR contributed the most to CSS prediction in the training (24.26%) and validation (32.31%) sets. A nomogram including TD and LNR showed satisfactory discriminative ability, and calibration curves indicated favorable consistency in both the training and validation sets. Conclusions: TD and LNR represent independent prognostic predictors for stage III CRC. A combination of TD and LNR could be used to identify those at high risk of CRC deaths.
Step into the era of large multimodal models: a pilot study on ChatGPT-4V(ision)’s ability to interpret radiological images
Authors: Lingxuan Zhu, Weiming Mou, Yancheng Lai, Jinghong Chen, Shujia Lin, Liling Xu, Junda Lin, Zeji Guo, Tao Yang, Anqi Lin, Chang Qi, Ling Gan, Jian Zhang, Peng Luo
Journal: International Journal of Surgery (2024)

Zhu, Lingxuan MD; Mou, Weiming MD; Lai, Yancheng MD; Chen, Jinghong MD; Lin, Shujia MD; Xu, Liling MD; Lin, Junda MD; Guo, Zeji MD; Yang, Tao MD; Lin, Anqi MD; Qi, Chang MEng; Gan, Ling MD; Zhang, Jian MD; Luo, Peng MD Author Information