tbuckley/cabot-search huggingface dataset:
Initial intramuscular dissection as a rescue therapy during peroral endoscopic myotomy for achalasia patients with severe submucosal fibrosis
Authors: Ahmad Madkour, Amr Elfouly, Hamdy Sayed, Ahmed El-tawansy, Ahmed Tawheed, Hassan Atalla
Journal: Endoscopy (2024)

Peroral endoscopic myotomy (POEM) is a well-established endoscopic therapy for achalasia with high success rates. Severe submucosal fibrosis correlates with prolonged procedure duration, higher perioperative complications, and even failed POEM. Methods to overcome severe submucosal fibrosis include changing to an anterior approach, simultaneous submucosal tunnel dissection [1], open POEM [2], and initial submucosal tunneling followed by through-muscle dissection [3], with variable rates of success and complications. Here, we present a novel and successful method of initial intramuscular dissection (IIMD) in two patients with severe submucosal fibrosis where submucosal tunneling was not possible ([Video 1]).
Multifocal stenosis in purulent appendicitis with fecalith
Authors: Fan Wang, Yue Zhu, Qiu Zhao, Hongling Wang
Journal: Endoscopy (2024)

A 32-year-old woman was admitted for abdominal pain around the navel for over 1 year. At the local hospital, an abdominal CT scan showed appendicitis and an appendiceal fecalith. Subsequently, endoscopic retrograde appendicitis therapy was prepared but failed because the guidewire and catheter could not access the appendix lumen [1]. As a result, the patient was referred to our hospital for further treatment.
Oral decitabine plus cedazuridine and venetoclax in patients with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukaemia: a single-centre, phase 1/2 study
Authors: Alex Bataller, Guillermo Montalban-Bravo, Alexandre Bazinet, Yesid Alvarado, Kelly Chien, Sangeetha Venugopal, Jo Ishizawa, Danielle Hammond, Mahesh Swaminathan, Koji Sasaki, Ghayas C Issa, Nicholas J Short, Lucia Masarova, Naval G Daver, Tapan M Kadia, Simona Colla, Wei Qiao, Xuelin Huang, Rashmi Kanagal-Shamanna, Stephany Hendrickson, Farhad Ravandi, Elias Jabbour, Hagop Kantarjian, Guillermo Garcia-Manero
Journal: The Lancet Haematology (2024)
A novel hood with a small-caliber tip and two traction strings for endoscopic submucosal dissection
Authors: Kinya Fujita, Yutaka Saito
Journal: Endoscopy (2024)

Traction techniques have been reported to be useful for performing endoscopic submucosal dissection (ESD) safely [1] [2]. We previously reported on use of the Dual Traction (DT) hood with two traction strings installed for performing ESD ([Fig. 1]) [3] [4] [5]. Herein, we report an improved DT hood with an attached small-caliber tip that we created, the DT hood type-S ([Fig. 2]).
Non-tip and rotatable sphincterotome for biliary cannulation in patients with Roux-en-Y gastrectomy
Authors: Haruo Miwa, Kazuya Sugimori, Kazuki Endo, Ritsuko Oishi, Hiromi Tsuchiya, Takashi Kaneko, Shin Maeda
Journal: Endoscopy (2024)

Balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography (BE-ERCP) has become widely used for patients with Roux-en-Y gastrectomy; however, selective biliary cannulation is still challenging [1] [2]. A non-tip or rotatable sphincterotome has been reported to be beneficial in difficult cases [3] [4] [5]. A novel sphincterotome, Seeking Tome Zero (MTW Endoskopie Manufaktur, Wesel, Germany) ([Fig. 1], [Fig. 2]), combines these features. Herein, we describe two successful cases with Roux-en-Y gastrectomy ([Video 1]).
Usefulness of a combination of an adaptive traction device and an insulated-type knife for a neoplastic lesion in ulcerative colitis
Authors: Elena De Cristofaro, Jérôme Rivory, Louis-Jean Masgnaux, Jérémie Jacques, Timothée Wallenhorst, Pierre Lafeuille, Mathieu Pioche
Journal: Endoscopy (2024)

Endoscopic resection has been recommended by current guidelines for superficial colorectal neoplasia in patients with ulcerative colitis (UC), especially for clearly visible colitis-associated neoplasia [1]. Endoscopic submucosal dissection (ESD) is useful in such patients to ensure en bloc resection, minimizing the risk of recurrence and colectomy in the future; however, endoscopic removal is technically challenging in UC, mainly owing to underlying inflammation and fibrosis [2]. Several devices and techniques have been described to facilitate the procedure. The IT Knife nano (Olympus, Japan) is a knife with an insulated tip covering the needle and a metal disc at the back of the insulated tip. It is designed to be pulled for resection with a traction mechanism. Additionally, a traction strategy using adaptive traction (ATRACT) devices has already been described as being particularly useful in complex lesions [3] [4] [5].
Endoscopic submucosal dissection using a detachable snare for a large colorectal tumor with muscle retraction
Authors: Shunsuke Horitani, Takeshi Yamashina, Natsuko Saito, Hironao Matsumoto, Masahiro Orino, Masataka Kano, Masaaki Shimatani
Journal: Endoscopy (2024)

Large colorectal sessile tumors sometimes exhibit severe submucosal fibrosis with muscle retraction [1]. Endoscopic submucosal dissection (ESD) for tumors with muscle retraction tends to result in incomplete resection because submucosal dissection is difficult and carries a risk of perforation [1]. Conventional methods such as the double-tunnel and pocket-creation methods are useful for large sessile tumors with muscle retraction because good traction can be maintained and the dissection line is easier to recognize [2] [3]. We report successful resection of a large colorectal tumor with muscle retraction at the center of the lesion using a detachable snare (PolyLoop Ligating Device; Olympus, Tokyo, Japan), which differs from conventional methods.
Association between Age and Mortality in Pediatric and Adult Acute Respiratory Distress Syndrome
Authors: Bhavesh M. Patel, John P. Reilly, Anoopindar K. Bhalla, Lincoln S. Smith, Robinder G. Khemani, Tiffanie K. Jones, Nuala J. Meyer, Michael O. Harhay, Nadir Yehya
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

The epidemiology, management, and outcomes of acute respiratory distress syndrome (ARDS) differ between children and adults, with lower mortality rates in children despite comparable severity of hypoxemia. However, the relationship between age and mortality is unclear.
Pulmonary Artery Pseudoaneurysm Caused by Pulmonary Mucormycosis
Authors: Mingqiang Zhang, Qiongzhen Luo, Xuesong Li, Xiangdong Mu, Weiwei Wu
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Pulmonary Artery Pseudoaneurysm Caused by Pulmonary Mucormycosis." American Journal of Respiratory and Critical Care Medicine, 209(7), pp. 879–880
Levonorgestrel-releasing intrauterine device therapy vs oral progestin treatment for reproductive-aged patients with endometrial intraepithelial neoplasia: a systematic review and meta-analysis
Authors: Yukio Suzuki, Jennifer S Ferris, Ling Chen, Shayan Dioun, John Usseglio, Koji Matsuo, Xiao Xu, Dawn L Hershman, Jason D Wright
Journal: JNCI Journal of the National Cancer Institute (2024)

Abstract Background We conducted a systematic review and meta-analysis to examine outcomes of patients with endometrial intraepithelial neoplasia treated with oral progestins or a levonorgestrel-releasing intrauterine device (IUD). Methods We conducted a systematic review across 5 databases to examine outcomes of progestational treatment (oral progestins or levonorgestrel-releasing IUD) for patients with endometrial intraepithelial neoplasia. The primary outcome was the best complete response rate within 12 months of primary progestational treatment. Sensitivity analyses were performed by removing studies with extreme effect sizes. Secondary outcomes included the pooled pregnancy rate. Results We identified 21 eligible studies, including 824 premenopausal patients with endometrial intraepithelial neoplasia, for our meta-analysis. Among these, 459 patients received oral progestin, and 365 patients received levonorgestrel-releasing IUD as a primary progestational treatment. The pooled best complete response proportion within 12 months was 82% (95% confidence interval [CI] = 69% to 91%) following oral progestin treatment and 95% (95% CI = 81% to 99%) following levonorgestrel-releasing IUD treatment. After removing outlier studies, the pooled proportion was 86% (95% CI = 75% to 92%) for the oral progestin group and 96% (95% CI = 91% to 99%) for the levonorgestrel-releasing IUD group, with reduced heterogeneity. The pooled pregnancy rate was 50% (95% CI = 35% to 65%) after oral progestin and 35% (95% CI = 23% to 49%) after levonorgestrel-releasing IUD treatment. Conclusions This meta-analysis provides data on the effectiveness of oral progestins and levonorgestrel-releasing IUD treatment within 12 months of treatment among premenopausal patients with endometrial intraepithelial neoplasia. Although based on small numbers, the rate of pregnancy after treatment is modest. These data may be beneficial for selecting progestational therapies that allow fertility preservation for patients with endometrial intraepithelial neoplasia.
Venous and arterial thrombosis in patients with VEXAS syndrome
Authors: Yael Kusne, Atefeh Ghorbanzadeh, Alina Dulau-Florea, Ruba Shalhoub, Pedro E. Alcedo, Khanh Nghiem, Marcela A. Ferrada, Alexander Hines, Kaitlin A. Quinn, Sumith R. Panicker, Amanda K. Ombrello, Kaaren Reichard, Ivana Darden, Wendy Goodspeed, Jibran Durrani, Lorena Wilson, Horatiu Olteanu, Terra Lasho, Daniel L. Kastner, Kenneth J. Warrington, Abhishek Mangaonkar, Ronald S. Go, Raul C. Braylan, David B. Beck, Mrinal M. Patnaik, Neal S. Young, Katherine R. Calvo, Ana I. Casanegra, Peter C. Grayson, Matthew J. Koster, Colin O. Wu, Yogendra Kanthi, Bhavisha A. Patel, Damon E. Houghton, Emma M. Groarke
Journal: Blood (2024)
Do Ultrafine Particles Carry Any Weight When It Comes to Progression of Pulmonary Fibrosis?
Authors: Mark W. Frampton
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Do Ultrafine Particles Carry Any Weight when It Comes to Progression of Pulmonary Fibrosis?." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Reply to Wendel-Garcia <i>et al</i>.: Low-Dose Anticoagulation to Prevent Intracranial Hemorrhage in COVID-19 Patients under Extracorporeal Membrane Oxygenation Support
Authors: Marco Giani, Matthieu Schmidt, Daniel Brodie, Roberto Lorusso, Antonio Arcadipane, Gennaro Martucci
Journal: American Journal of Respiratory and Critical Care Medicine (2024)
Anti-GABAA receptor encephalitis 14 months after allogeneic haematopoietic stem-cell transplant for acute myeloid leukaemia
Authors: Thilo Rusche, Özgür Yaldizli, Riccardo Galbusera, Matthias Mutke, Jörg P Halter, Johanna Lieb, Francesca Matteazzi, Anne Stelmes, Jan Bittner, Pascale Grzonka, Nicole Frank, Dominik Cordier, Jürgen Hench, Stephan Frank, Hans H Hirsch, Urs Fischer, Jens Kuhle, Raoul Sutter, Stephan Rüegg, Urs Fisch
Journal: The Lancet (2024)
Low-Dose Anticoagulation to Prevent Intracranial Hemorrhage in COVID-19 Patients under Extracorporeal Membrane Oxygenation Support
Authors: Pedro David Wendel-Garcia, Benjamin Seeliger, Daniel Hofmaenner, Christian Bode, Klaus Stahl, Sascha David
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Low Dose Anticoagulation to Prevent Intra-Cranial Hemorrhage in Covid-19 Patients Under ECMO Support." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Efferocytosis‐Inspired Biomimetic Nanoplatform for Targeted Acute Lung Injury Therapy
Authors: Zhiwei Huang, Xinze Li, Dedong Yu, Hengcai Wang, Changju Chun, Yingzheng Zhao
Journal: Advanced Healthcare Materials (2024)

Acute lung injury (ALI) is a serious inflammatory disease that causes impairment of pulmonary function. Phenotypic modulation of macrophage in the lung using fibroblast growth factor 21 (FGF21) may be a potential strategy to alleviate lung inflammation. Consequently, achieving specific delivery of FGF21 to the inflamed lung and subsequent efficient FGF21 internalization by macrophages within the lung becomes critical for effective ALI treatment. Here, an apoptotic cell membrane-coated zirconium-based metal-organic framework UiO-66 is reported for precise pulmonary delivery of FGF21 (ACM@U-FGF21) whose design is inspired by the process of efferocytosis. ACM@U-FGF21 with apoptotic signals is recognized and internalized by phagocytes in the blood and macrophages in the lung, and then the intracellular ACM@U-FGF21 can inhibit the excessive secretion of pro-inflammatory cytokines by these cells to relieve the inflammation. Utilizing the homologous targeting properties inherited from the source cells and the spontaneous recruitment of immune cells to inflammatory sites, ACM@U-FGF21 can accumulate preferentially in the lung after injection. The results prove that ACM@U-FGF21 effectively reduces inflammatory damage to the lung by modulating lung macrophage polarization and suppressing the excessive secretion of pro-inflammatory cytokines by activated immune cells. This study demonstrates the usefulness of efferocytosis-inspired ACM@U-FGF21 in the treatment of ALI.
When I use a word . . . Medical hypercorrection
Authors: Jeffrey K Aronson
Journal: BMJ (2024)

I define "hypercorrection as "incorrectly correcting what's already correct, wrongly thinking it to be wrong." The example that is usually quoted when defining the word is "between you and I," which should be "between you and me." Apologists for this misuse give several reasons: they say that "you and I" is a compound pronoun in the objective (accusative) case; they say that great writers have often used the form in this way; they say that many people do it now, so it must be OK. All very sophistical. Another example, a medical hypercorrection, is when an <i>e</i> is turned into an <i>ae</i> or an <i>oe</i>, in the belief that the <i>e</i> is an Americanism, just as "anemia" and "estrogen" are American forms of "anaemia" and "oestrogen." This happens when people write, for example, "pancytopaenia" or "pancytopoenia" instead of the correct form, "pancytopenia." What they don't know is that the suffix –penia comes from a Greek word, πενία, meaning poverty. To add in an <i>a</i> or an <i>o</i> before the <i>e</i>, assuming that you are ridding the world of a supposedly vile Americanism, is an aegroegious error.
Antegrade stenting using a new covered multi-hole metal stent for malignant biliary obstruction in surgically altered anatomy
Authors: Kojiro Tanoue, Hirotsugu Maruyama, Yoshinori Shimamoto, Tatsuya Kurokawa, Yuki Ishikawa-Kakiya, Akira Higashimori, Yasuhiro Fujiwara
Journal: Endoscopy (2024)

Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) with antegrade stenting has recently been applied to malignant biliary obstruction including in surgically altered anatomy [1] [2]. This method has reduced the rate of bile leakage, which is expected to prevent stent migration [3], and prolong time to stent dysfunction [4]. In surgically altered anatomy, there is a concern that a covered self-expandable metal stent (SEMS) can cause the other hepatic ducts to occlude as the distance between the anastomosis and bifurcation is small. The commonly used uncovered SEMS may result in tumor ingrowth. We report successful EUS-HGS with antegrade stenting using a new fully covered multi-hole SEMS (HANARO Biliary Multi-Hole NEO; M.I.Tech Co Ltd., Pyeongtaek, South Korea) ([Fig. 1]) for malignant biliary obstruction in surgically altered anatomy.
Injectable and Thermosensitive Hydrogel with Platelet‐Rich Plasma for Enhanced Biotherapy of Skin Wound Healing
Authors: Gengjun Liu, Yuanming Yang, Yan Liu, Ying Li, Mingyuan Jiang, Yaxin Li, Zifan Meng, Zhen Zhao, Zheng Liu, Jiao Liu, Dongmei Ge, Haiyan Wang
Journal: Advanced Healthcare Materials (2024)

Abstract The rapid and effective healing of skin wounds resulted from severe injuries and full‐layer skin defects remains a pressing clinical challenge in contemporary medical practice. The reduction of wound infection and rapid healing is helpful to rebuild and repair skin tissue. Here, a thermosensitive chitosan‐based wound dressing hydrogel incorporating β‐glycerophosphate (GP), hydroxy propyl cellulose (HPC), graphene oxide (GO), and platelet‐rich plasma (PRP) is developed, which exhibits the dual functions of antibacterial properties and repair promotion. GP and HPC enhance the mechanical properties through forming hydrogen bonding connection, while GO produces local heat under near‐infrared light, leading to improved blood circulation and skin recovery. Notably, antibacterial properties against Pseudomonas aeruginosa , and control–release of growth factors from PRP are also achieved based on the system. In vitro experiments reveal its biocompatibility, and ability to promote cell proliferation and migration. Animal experiments demonstrate that the epithelial repair and collagen deposition can be promoted during skin wound healing in Sprague Dawley rats. Moreover, a reduction in wound inflammation levels and the improvement of wound microenvironment are observed, collectively fostering effective wound healing. Therefore, the composite hydrogel system incorporated with GO and PRP can be a promising dressing for the treatment of skin wounds.
Management of ALL in adults: 2024 ELN recommendations from a European expert panel
Authors: Nicola Gökbuget, Nicolas Boissel, Sabina Chiaretti, Hervé Dombret, Michael Doubek, Adele Fielding, Robin Foà, Sebastian Giebel, Dieter Hoelzer, Mathilde Hunault, David I. Marks, Giovanni Martinelli, Oliver Ottmann, Anita Rijneveld, Philippe Rousselot, Josep Ribera, Renato Bassan
Journal: Blood (2024)

Abstract Experts from the European Leukemia Net (ELN) working group for adult acute lymphoblastic leukemia have identified an unmet need for guidance regarding management of adult acute lymphoblastic leukemia (ALL) from diagnosis to aftercare. The group has previously summarized their recommendations regarding diagnostic approaches, prognostic factors, and assessment of ALL. The current recommendation summarizes clinical management. It covers treatment approaches, including the use of new immunotherapies, application of minimal residual disease for treatment decisions, management of specific subgroups, and challenging treatment situations as well as late effects and supportive care. The recommendation provides guidance for physicians caring for adult patients with ALL which has to be complemented by regional expertise preferably provided by national academic study groups.
Linking biodiversity, ecosystem function, and Nature’s contributions to people: a macroecological energy flux perspective
Authors: Ana Carolina Antunes, Emilio Berti, Ulrich Brose, Myriam R. Hirt, Dirk N. Karger, Louise M.J. O’Connor, Laura J. Pollock, Wilfried Thuiller, Benoit Gauzens
Journal: Trends in Ecology & Evolution (2024)

At macroecological scales, the provision of Nature's contributions to people (NCP) is mostly estimated with biophysical information, ignoring the ecological processes underlying them. This hinders our ability to properly quantify the impact of declining biodiversity and the provision of NCP. Here, we propose a framework that combines local-scale food web energy flux approaches and large-scale biodiversity models to evaluate ecosystem functions and flux-related NCP at extensive spatiotemporal scales. Importantly, this approach has the potential to upscale ecosystem functions, assess the vulnerability of flux-related NCP to the climate crisis, and support the development of multiscale mitigation policies.
Alzheimer's disease current therapies, novel drug delivery systems and future directions for better disease management
Authors: Baljinder Singh, Candace M. Day, Sadikalmahdi Abdella, Sanjay Garg
Journal: Journal of Controlled Release (2024)

Alzheimer's disease (AD), is a neurodegenerative disorder that escalates with time, exerting a significant impact on physical and mental health and leading to death. The prevalence of AD is progressively rising along with its associated economic burden and necessitates effective therapeutic approaches in the near future. This review paper aims to offer an insightful overview of disease pathogenesis, current FDA-approved drugs, and drugs in different clinical phases. It also explores innovative formulations and drug delivery strategies, focusing on nanocarriers and long-acting medications (LAMs) to enhance treatment efficacy and patient adherence. The review also emphasizes preclinical evidence related to nanocarriers and their potential to improve drug bioavailability, pharmacokinetics, and pharmacodynamics parameters, while also highlighting their ability to minimize systemic side effects. By providing a comprehensive analysis, this review furnishes valuable insights into different pathophysiological mechanisms for future drug development. It aims to inform the development of treatment strategies and innovative formulation approaches for delivering existing molecules in Alzheimer's disease, ultimately striving to improve patient compliance.
Continuous PEGasparaginase Dosing Reduces Hypersensitivity Reactions in Pediatric ALL: A Dutch Childhood Oncology Group ALL11 Randomized Trial
Authors: Inge M. van der Sluis, Leiah J. Brigitha, Marta Fiocco, Hester A. de Groot-Kruseman, Marc Bierings, Cor van den Bos, Valerie de Haas, Peter M. Hoogerbrugge, Wim J.E. Tissing, Margreet A. Veening, Rob Pieters
Journal: Journal of Clinical Oncology (2024)

The primary objective of this randomized study was to determine whether a continuous dosing schedule (without the asparaginase-free interval) would result in less hypersensitivity reactions to PEGasparaginase (PEGasp) compared with the standard noncontinuous dosing schedule.
Polymorphisms and haplotypes of TOLLIP and MUC5B are associated with susceptibility and survival in patients with fibrotic hypersensitivity pneumonitis
Authors: P.C. Mota, M.L. Soares, A.C. Ferreira, R.F. Santos, J.C. Rufo, D. Vasconcelos, A. Carvalho, S. Guimarães, F. Vasques-Nóvoa, C. Cardoso, N. Melo, A.T. Alexandre, D. Coelho, H. Novais-Bastos, A. Morais
Journal: Pulmonology (2024)

Hypersensitivity pneumonitis (HP) is an interstitial lung disease with diverse clinical features that can present a fibrotic phenotype similar to idiopathic pulmonary fibrosis (IPF) in genetically predisposed individuals. While several single nucleotide polymorphisms (SNPs) have been associated with IPF, the genetic factors contributing to fibrotic HP (fHP) remain poorly understood. This study investigated the association of