tbuckley/cabot-search huggingface dataset:
Management of Posterior Cruciate Ligament Injuries
Authors: Shuguang Gao, Jiahao Meng, Chao Zeng, Joan C. Monllau, Robert F. LaPrade, Timothy N. Taft, Jeffrey H. Berg, Michael J. Medvecky, Kevin R Stone, Michael J. Scarcella, Frank A. Cordasco, Brian R. Wolf, Dustin L. Richter, Scott Rodeo, Timothy E. Hewett, Bruce A. Levy, James Lee Pace, Bobby Anand, Filippo Picinini, Riccardo D’Ambrosi, Luca Maria Sconfienza, Luca Farinelli, Bancha Chernchujit, Anders Stålman, Amit Gilad, Srinivas B S Kambhampati, Silvampatti Ramasamy Sundararajan, Abayo Remy Patrick, Juvenal Nshimirimana, Pisit Lertwanich, Michael Opoku, Thana Buranapuntaruk, Leonardo Addeo Ramos, Hui Hoi Po James, Terence D’Souza, Alberto Grassi, Mohammad Razi, Jaime Marino, Manuel Mqsquera, Johannes Barth, Dinshaw N. Pardiwala, Yusheng Li, Wenfeng Xiao, Yilin Xiong, Pan Liu, Liu Yang, Panghu Zhou, Yan Xu, Xizhuang Bai, Tengbo Yu, Chunbao Li, Licheng Wei, Liangjun Li, Juan Wang, Decheng Shao, Zhenpeng Guan, Xuesong Dai, Jingmin Huang, Jian Li, Weiping Li, Guangji Wang, Bing Yue, Zhizeng Gao, Lin Guo, Yinghui Hua, Meng Wu, Jing Wang, Xiaofei Zheng, Lunhao Bai, Jiwu Chen, Weihong Zhu, Qichun Zhao, Weiguo Zhang, Zhiwei Chen, Xiaochun Wei, Wei Lu, Ziquan Yang, Qingjun Wei, Liaobin Chen, Songcen Lv, Ning Liu, Yongsheng Xu, Yanlin Li, Xuesong Wang, Hui Zhang, Weidong Xu, Qing Jiang, Tianlong Huang, Jiakuo Yu, Jiang Zheng, Keyuan Zhang, Jianquan Wang, Guanghua Lei
Journal: International Journal of Surgery (2025)

Background: Posterior cruciate ligament (PCL) injury is a relatively common musculoskeletal condition. However, there is currently a lack of consensus on decision-making, treatment and postoperative management for such injuries. Objectives: To use the modified Delphi method to reach expert consensus on the management of PCL injury. Methods: A literature search of PubMed, Cochrane Library, Embase, and Web of Science for articles up to 17 October 2024, to support the development of recommendation statements. An Expert Panel of 90 experienced clinicians from orthopaedics and sports medicine participated in a two-round Delphi process. Each statement was evaluated in two parts: the first part assessed content appropriateness (score of 7-9 indicating appropriateness and 4-6 indicating possible appropriateness), while the second part assessed agreement (score of 5-9 indicating agreement). Results: The panel members developed 11 statements using the Delphi process, addressing the following topics: (1) clinical decision-making, (2) treatment, and (3) postoperative management about PCL injuries. The final consensus was reached on 11 statements and we eventually translated these statements into a corresponding table of expert recommendations. Conclusion: Consensus was reached on 11 statements regarding three aspects of PCL injury management. These findings provide a foundation for developing evidence-based guidelines that can enhance clinical decision-making, improve treatment strategies, and optimize postoperative care for patients with PCL injuries.
Global variations and socioeconomic inequalities in lifetime risk of lip, oral cavity, and pharyngeal cancer: a population-based systematic analysis of GLOBOCAN 2022
Authors: Yuhao Li, Jiehua Tian, Yile You, Ru Chen, Rongshou Zheng, Shengfeng Wang, Freddie Bray
Journal: International Journal of Surgery (2025)

Background: In 2021, the World Health Organization (WHO) identified poor oral health as a major health expenditure burden. While lip, oral cavity, and pharyngeal cancers (LOCP) are an important group of diseases threatening oral health, there have been limited studies assessing global variations in lifetime risks (LR) according to socioeconomic inequalities. Materials and methods: We obtained national incidence and mortality estimates of LOCP in 185 countries from the GLOBOCAN database of the International Agency for Research on Cancer (IARC), corresponding all-cause mortality, population data, and the Human Development Index (HDI, with higher values indicating superior socioeconomic level) through the United Nations, alongside oral health-related data through WHO and INDEXBOX. LR were calculated using the adjusted multiple primary method. Results: In 2022, the global LR of developing and dying from LOCP were 0.92% (95% CI: 0.92%–0.92%) and 0.48% (95% CI: 0.48%–0.48%), respectively, with the highest burden associated with cancers of the lip and oral cavity. The LR of being diagnosed with LOCP or dying from the disease were 2.24 (95% CI: 2.22–2.25) and 2.30 (95% CI: 2.27–2.33) times higher among males relative to females. The highest LR for lip and oral cavity, salivary gland, oropharynx, and hypopharynx cancers were largely concentrated in Australia/New Zealand, Europe, and North America; whereas nasopharynx cancer was more frequent in parts of Asia and Africa. The LR of developing and dying from LOCP were positively associated with HDI, dental healthcare expenditure, areca nut consumption, the availability of refined sugar, and early screening for oral diseases, and negatively associated with the prevalence of severe periodontal disease. Although the LR of LOCP decreased with age, the rate of decline was relatively slow until the age of 50, and even at age 70, there remained non-negligible risks. Conclusion: Global variations in the LR of developing and dying from LOCP by subsite, sex and age reveal significant disparities by world region, socioeconomic levels and oral healthcare factors.
Machine learning-based forecasting of daily acute ischemic stroke admissions using weather data
Authors: Nandhini Santhanam, Hee E Kim, David Rügamer, Andreas Bender, Stefan Muthers, Chang Gyu Cho, Angelika Alonso, Kristina Szabo, Franz-Simon Centner, Holger Wenz, Thomas Ganslandt, Michael Platten, Christoph Groden, Michael Neumaier, Fabian Siegel, Máté E Maros
Journal: npj Digital Medicine (2025)

Abstract The climate crisis underscores the need for weather-based predictive analytics in healthcare, as weather factors contribute to ~11% of the global stroke burden. Therefore, we developed machine learning models using locoregional weather data to forecast daily acute ischemic stroke (AIS) admissions. An AIS cohort of 7914 patients admitted between 2015 and 2021 at the tertiary University Medical Center Mannheim, Germany, with a 600,000-population catchment area, was geospatially matched to German Weather Service data. Poisson regression, boosted generalized additive models, support vector machines, random forest, and extreme gradient boosting (XGB) were evaluated within a time-stratified nested cross-validation framework. XGB performed best (mean absolute error: 1.21 cases/day). Maximum air pressure was the top predictor, with temperature exhibiting a bimodal link. Cold and heat stressor days ( T min_lag3 &lt; −2 °C; T perceived &lt; −1.4 °C; T min_lag7 &gt; 15 °C) and stormy conditions (wind gusts &gt; 14 m/s) increased stroke admissions. This generalizable framework could aid real-time hospital planning, effective care and forecasting of various weather-related disease burdens.
Soluble CD46 improves detection of hepatic steatosis by contrast-enhanced computed tomography before liver surgery
Authors: Paul Kupke, Laura S. Kupke, Gunther Glehr, Katja Evert, Ingo Einspieler, Matthias Hornung, Christian Stroszczynski, Edward K. Geissler, Hans J. Schlitt, James A. Hutchinson, Jens M. Werner
Journal: International Journal of Surgery (2025)
Efficacy and safety of intra-arterial thrombolysis after endovascular reperfusion for acute ischemic stroke: a systematic review and meta-analysis of randomized trials
Authors: Yu Guo, Guang Yang, Yuwei Ding, Chao Liu, Zhiyuan Shen, Hengzhu Zhang, Qiangji Bao, Wenmiao Luo
Journal: International Journal of Surgery (2025)

Objective: This pooled analysis aims to evaluate the efficacy and safety of intra-arterial thrombolysis (IAT) following near-complete to complete reperfusion by endovascular thrombectomy (EVT) in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). Methods: We conducted a search of PubMed, Embase, and Cochrane databases to identify randomized controlled trials (RCTs) investigating the adjunct benefit of IAT in patients with AIS-LVO who had achieved a score on the Thrombolysis In Cerebral Infarction (TICI) scale of 2b-3 after EVT. Efficacy outcomes encompassed excellent functional outcome, defined as a modified Rankin Scale (mRS) score of 0-1 at 90 days, and functional independence (mRS 0-2). Safety outcomes included symptomatic intracranial hemorrhage (sICH) and mortality at 90 days. A network meta-analysis (NMA) was performed to evaluate the effects of different types of intra-arterial thrombolytic agents on mRS 0-1. Results: A total of 7 RCTs were included in the analysis, involving 2,128 patients. Relative risks (RR) and 95% confidence intervals (CI) were pooled using a random-effects model. The pooled results indicated that adjunctive IAT did not significantly improve the rate of functional independence (RR 1.04, 95% CI 0.96-1.13, P = 0.29). However, there was a significant increase in excellent functional outcome with adjunctive IAT (RR 1.23, 95% CI 1.11-1.36, P &lt; 0.001). The pooled analysis did not demonstrate any differences between EVT + IAT and EVT only in rates of sICH (RR 1.23, 95% CI 0.81-1.85, P = 0.33) or 90-day mortality (RR: 0.98, 95% CI: 0.82-1.18; P = 0.86). The NMA found no significant difference in achieving mRS 0-1 among arterial adjunctive alteplase, tenecteplase, and urokinase following successful reperfusion. Conclusions: IAT as an adjunct to successful EVT appears to enhance excellent functional outcome in patients with AIS-LVO without a significant increase in sICH and mortality.
Same-day discharge vs. inpatient stay in laparoscopic sleeve gastrectomy: a systematic review and meta-analysis
Authors: Zina Mobarak, Shahd Mobarak, Salma Mahmoud, Hussameldin M Nour, Ashok Menon
Journal: International Journal of Surgery (2025)

Background: Laparoscopic sleeve gastrectomy (LSG) is the most commonly performed bariatric operation globally. Same-day discharge (SDD) LSG is now becoming increasingly common, with many studies reporting this to be safe when compared to a postoperative inpatient (IP) stay. This systematic review and meta-analysis aims to compare outcomes between patients undergoing LSG as SDD and IP. Materials and methods: A systematic review and meta-analysis was conducted according to the PRISMA guidelines. A search strategy was developed and used to search the MEDLINE/Pubmed, Cochrane library, EMBASE, and Scopus databases. The primary outcome measures were mortality, emergency room (ER) visits, readmission, and reoperation. Secondary outcomes were morbidity, postoperative leak, length of stay of rehospitalization, cancellation of planned day-case, reasons for cancellations, postoperative pulmonary embolism (PE), and postoperative deep vein thrombosis (DVT). Pooled odds ratios with 95% confidence intervals were calculated for outcomes using fixed- or random-effects models. Results: 11 studies were identified and included in the qualitative analysis, with a total of 138 001 patients in the SDD (25 069) or IP (112 932) groups. Seven studies with a total of 3737 patients were included in the meta-analysis. The number of ER visits was significantly higher in the IP group compared to the SDD group (OR = 1.52, 95% CI: 1.09–2.13, P = 0.01). There was no significant difference in the readmission rate (OR = 1.48, 95% CI: 0.80–2.76, P = 0.21) or the reoperation rate (OR = 0.62, 95% CI: 0.12–3.25, P = 0.58). Mortality and morbidity were low in all studies where they were reported and were largely similar across the groups. Conclusion: Overall, SDD LSG when compared to IP LSG is safe and not associated with higher mortality, morbidity, readmission, reoperation rates, or ER visits.
An Injectable Multifunctional Nanosweeper Eliminates Cardiac Mitochondrial DNA to Reduce Inflammation (Adv. Healthcare Mater. 11/2025)
Authors: Yi‐Jing Li, Xiumeng Hua, Yi‐Qi Zhao, Han Mo, Shun Liu, Xiao Chen, Zhe Sun, Weiteng Wang, Qian Zhao, Zeyu Cui, Tao An, Jiangping Song
Journal: Advanced Healthcare Materials (2025)
Dual‐Enhanced Nanohybrids for Synergistic Photothermal and Photodynamic Therapy in Cancer Treatment with Immune Checkpoint Inhibitors (Adv. Healthcare Mater. 11/2025)
Authors: Dabin Lee, Hyungjin Sun, Jieun Bang, Tae‐Young Heo, Duong Thi‐Thuy Pham, Jong Dae Jang, Young Soo Han, Tae Joo Shin, Soo‐Hyung Choi, JaeHong Park, Junsang Doh, Juhyun Park
Journal: Advanced Healthcare Materials (2025)
Patient-reported outcomes by individuals with differentiated thyroid cancer who underwent minimal-access versus conventional open thyroidectomy: a real-world propensity score-matching study
Authors: Yuqin Zhou, Hao Tian, Guozhi Zhang, Baoquan Hu, Yingjiao Wang, Wenting Yan, Xiujuan Wu, Kongyong Zhang, Jun Deng, Yan Liang, Xiaowei Qi, Lin Ren, Yi Zhang
Journal: International Journal of Surgery (2025)

Background: Minimal-access surgery has been widely used in differentiated thyroid cancer (DTC) management and its therapeutic effectiveness is well-proven. However, little is known about how minimal-access thyroidectomy affects patient-reported outcomes (PRO). Materials and methods: In this real-world cross-sectional study, 6221 patients with DTC who underwent minimal-access or conventional open thyroidectomy were included and required to fill out PRO questionnaires, including the Thyroid Cancer-Specific Quality of Life, the European Organisation for Research and Treatment of Cancer’s Core Quality of Life Questionnaire, and Fear of Progression Questionnaire-Short Form. Of the 3586 patients who completed the questionnaires entirely, 915 and 2671 belonged to the minimal-access and open groups, respectively. To reduce bias and balance confounding factors, propensity score matching was performed, after which 1818 patients were equally divided between the two groups. Results: Compared with the open group, the minimal-access group reported better PRO in terms of the THYCA-QOL summary score ( P &lt; 0.001), neuromuscular ( P = 0.038), voice ( P &lt; 0.001), concentration ( P = 0.044), sympathetic ( P = 0.002), throat/mouth ( P &lt; 0.001), and scar ( P &lt; 0.001), feeling chilly ( P &lt; 0.001), and tingling hands/feet ( P = 0.002). Subgroup analysis demonstrated that minimal-access thyroidectomy can be optimal for most patients from the PRO perspective. Moreover, longitudinal PRO comparisons indicated that at ≤6 months postoperatively, the open group experienced more problems in neuromuscular, voice, sympathetic, throat/mouth, scar, feeling chilly, tingling hands/feet, headache, and lower global health status scores (all P &lt; 0.05). However, except for voice, scar and tingling hands/feet, nearly all the differences disappeared after 7 months postoperatively. Intergroup comparisons suggested that the minimal-access group required less time to recover to a stable state. Conclusions: The minimal-access group exhibited significantly superior postoperative PRO compared to the open group. Furthermore, the PRO trajectories of the two groups differed, with the minimal-access group demonstrating a considerably shorter recovery time. If better PRO is desired, minimal-access thyroidectomy may be preferred.
Effective Hydrogel Vascular Patch Dual‐Loaded with Cycloastragenol Nanostructured Lipid Carriers and Doxycycline for Repairing Extravascular Injury in Abdominal Aortic Aneurysm (Adv. Healthcare Mater. 11/2025)
Authors: Du Chen, Tiantian Song, Yi Liu, Ying Wang, Boyang Qin, Qingyi Zhang, Weipeng Hu, Xiqiao Zhou, Rong Qi
Journal: Advanced Healthcare Materials (2025)
Multiscale Thermal Analysis of Gold Nanostars in 3D Tumor Spheroids: Integrating Cellular‐Level Photothermal Effects and Nanothermometry via X‐Ray Spectroscopy (Adv. Healthcare Mater. 11/2025)
Authors: Rosalía López‐Méndez, Anastasiia Dubrova, Javier Reguera, Rául Magro, Fátima Esteban‐Betegón, Ana Parente, Miguel Ángel García, Julio Camarero, Emiliano Fonda, Claire Wilhelm, Álvaro Muñoz‐Noval, Ana Espinosa
Journal: Advanced Healthcare Materials (2025)
Thioether‐Functionalized Cellulose for the Fabrication of Oxidation‐Responsive Biomaterial Coatings and Films (Adv. Healthcare Mater. 11/2025)
Authors: Eric M. DuBois, Kate E. Herrema, Matthew G. Simkulet, Laboni F. Hassan, Payton R. O'Connor, Riya Sen, Timothy M. O'Shea
Journal: Advanced Healthcare Materials (2025)
Abstract 1260: Acute Metformin Therapy Confers Cardioprotection Via an AMPK-eNOS-Dependent Pathway
Authors: John W Calvert, Susheel Gundewar, David J Lefer
Journal: Circulation (2007)

Background: Clinical reports indicate that the widely used anti-hyperglycemic drug, metformin, reduces cardiovascular end points of type 2 diabetics by actions that cannot be solely attributed to i...
Prediction of resistance to hydroxyurea therapy in patients with polycythemia vera: a machine learning study (PV-AIM) validated in a prospective interventional phase IV trial (HU-F-AIM)
Authors: Florian H Heidel, Valerio De Stefano, Matthias Zaiss, Jens Kisro, Eva Gückel, Susanne Großer, Mike W Zuurman, Kirsi Manz, Kenneth Bryan, Armita Afsharinejad, Martin Griesshammer, Jean-Jacques Kiladjian
Journal: Leukemia (2025)

Abstract Polycythemia vera (PV) is a myeloproliferative neoplasm associated with increased thromboembolic (TE) risk and hematologic complications. Hydroxyurea (HU) serves as the most frequently used first-line cytoreductive therapy worldwide; however, resistance to HU (HU-RES) develops in a significant subset of patients, leading to increased morbidity and necessitating alternative treatments. This study, part of the PV-AIM project, employed machine learning techniques on real-world evidence (RWE) from the Optum® EHR database containing 82.960 PV patients to identify baseline predictors of HU-RES within the first 6–9 months of therapy. Using a Random Forest model, the study analyzed data from 1850 patients, focusing on laboratory parameters and clinical characteristics. Key predictive markers included red cell distribution width (RDW) and hemoglobin (HGB), showing the strongest association with HU-RES. A synergistic interaction between RDW and HGB was identified, enabling TE risk stratification. This study provides a robust framework for early detection of HU-RES using readily available clinical data, facilitating timely intervention. These findings underscore the importance of personalized treatment approaches in managing PV and highlight the utility of machine learning in enhancing predictive accuracy and clinical outcomes. Based on the results of PV-AIM we initiated an open-label, prospective, single-arm, interventional, phase IV study (HU-F-AIM) evaluating HU-resistance/intolerance. Validation of predictive biomarkers may facilitate identification of patients at risk of HU resistance who may benefit from alternative treatment options, possibly preventing ongoing phlebotomy during HU treatment, a frequent therapeutic choice in high-risk PV associated with early disease progression and increased thromboembolic complications. We propose an updated terminology that differentiates between true molecular resistance and clinical resistance, that may indicate the requirement for alternative therapeutic strategies.
Author Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
Authors: Conan G Kinsey, Soledad A Camolotto, Amelie M Boespflug, Katrin P Guillen, Mona Foth, Amanda Truong, Sophia S Schuman, Jill E Shea, Michael T Seipp, Jeffrey T Yap, Lance D Burrell, David H Lum, Jonathan R Whisenant, G Weldon Gilcrease, Courtney C Cavalieri, Kaitrin M Rehbein, Stephanie L Cutler, Kajsa E Affolter, Alana L Welm, Bryan E Welm, Courtney L Scaife, Eric L Snyder, Martin McMahon
Journal: Nature Medicine (2025)
Effectiveness of influenza vaccination in preventing severe COPD exacerbations and pneumonia before, during, and after the COVID-19 pandemic: a retrospective cohort study
Authors: Sophia Eilat Tsanani, Shani Yorav, Shlomit Yaron, Talish Razi, Matan Yechezkel, Ronen Arbel, Dan Yamin
Journal: The Lancet Regional Health - Europe (2025)
Integrating Optical Genome Mapping With <scp><i>TP53</i> FISH</scp>: A Synergistic Approach for Cytogenomic Analysis in Chronic Lymphocytic Leukemia
Authors: Joanna Kamaso, Rocío García‐Serra, Marina Munné, María Rodríguez‐Rivera, Carme Melero, Sílvia Ramos‐Campoy, Marta Salido, Marta Lorenzo, Eva Gimeno, Joan Gibert, Peter Vandenberghe, Katrina Rack, Anna Puiggros, Barbara Dewaele, Blanca Espinet
Journal: American Journal of Hematology (2025)
Identification of disease genes by expression profiling
Authors: R. Bals, B. Jany
Journal: European Respiratory Journal (2001)

The human genome has been completely sequenced. The development of innovative methodologies and tools to understand the functions of human genes in health and disease will allow the data of the human genome project to be utilized. This paper reviews methods that can be used to detect and isolate genes that are specifically expressed in certain diseases or that are specific to cell types. First, classical methods, such as differential screening of complementary deoxyribonucleic acid libraries and subtractive techniques, are described. Methods based on polymerase chain reaction (PCR), such as differential display PCR or serial analysis of gene expression, will then be discussed. Finally, recent developments in gene chip technology and basic principles of functional genomics will be illustrated. Future developments will link the results of genomic approaches to data obtained by other systematic methods, such as proteomics ( i.e. the systematic, large scale analysis of proteins), and will allow the production of a detailed molecular characterization of diseases, disease stages, tissues, or cell types. Methods to detect disease or cell type-specific gene expression patterns will play an important role in the future of basic research, as well as the development of novel diagnostic procedures and identification of therapeutic targets.
GENebu Project: home nebulizer use and maintenance in Italy
Authors: A.S. Melani, P. Sestini, S. Aiolfi, N. Barbato, P. Canessa, G. De Angelis, D. Zanchetta, R. De Tullio, C. Cinti, M. Neri
Journal: European Respiratory Journal (2001)

Due to the lack of information on this topic, the Educational Group of the Italian Association of Hospital Pneumologists performed an open, multicentre, observational survey to evaluate home nebulizer practices in Italy. From May–December 1999, all patients attending one of the 27 participating chest clinics throughout Italy and who were or had been using a home nebulizer in the previous 6 months were consecutively enrolled. All patients completed a self-administered questionnaire on their current practices of home nebulization. Of the 1,721 questionnaires delivered, 1,257 were returned with an overall response rate of 73%. Most patients (82.8%) reported using their nebulizer for bronchopulmonary symptoms and the remaining patients only used theirs for upper respiratory tract diseases. Subjects using their nebulizer for lower respiratory symptoms were older (p&lt;0.001), predominantly female (p&lt;0.001) and used their nebulizer more frequently (p&lt;0.001). Forty per cent of patients &gt;60 yrs old used their nebulizer regularly, at least once a day. More than 60% of respondents never received any information from healthcare workers on the correct usage of their nebulizer, and &gt;75% received no information on nebulizer hygiene and care. Patients who received information on the use and maintenance of their nebulizer from caregivers more commonly attended to these practices (p&lt;0.01). The present survey suggests that home nebulizer use and maintenance in Italy are heterogeneous, and there is the need to implement better nebulizer practice.