tbuckley/cabot-search huggingface dataset:
Abstract 17432: Influence of Smoking on Arterial Stiffness - A Racial Comparison
Authors: Vivek Menon, Joseph Poole, Emir Veledar, Alanna Morris, Riyaz S Patel, Rebecca Din-Dzietham, Dorothy Coverson, Gary Gibbons, Viola Vaccarino, Arshed Quyyumi
Journal: Circulation (2011)

BACKGROUND: Although an association between smoking and arterial stiffness has been well established, whether this varies by ethnicity remains a subject of controversy. We hypothesized that the association between smoking and increased arterial stiffness is race-specific. METHODS: White (n=285, 36 smokers) and black (n=317, 91 smokers) participants (mean age 50±9, 57% female) from the Morehouse-Emory Partnership to Eliminate Cardiovascular Health Disparities (META-Health) study underwent measurement of central augmentation index (CAIx), a composite measure of arterial wave reflections and stiffness using applanation tonometry (SphygmoCor, AtCor). Mixed statistical models were used to determine whether race, age, gender, glucose, lipid parameters, systolic blood pressure (SBP), triglycerides and waist circumference (WC) were predictors of change in CAIx caused by smoking. RESULTS: Age, gender, race, SBP, WC and smoking were found to be independent predictors of CAIx (all P&lt;0.05). The two-way interaction (adjusted for all risk factors) between race and smoking on CAIx was statistically significant. Moreover, CAIx (corrected for heart rate at 75 beats per minute) were similar in white and black non-smokers (20.3 and 21.0, respectively), but significantly higher in black compared to white smokers (21.3 vs.26.4, p=0.027, respectively). CONCLUSIONS: Race is a strong predictor of the degree of change in arterial stiffness in conjunction with smoking, with black smokers having higher CAIx. There were no racial differences in non-smokers. The mechanisms by which smoking predisposes blacks to developing arterial stiffness need to be investigated.
Abstract 2135: Alteration Of Metalloproteinase Expression Profile In Proximal Pulmonary Arterial Wall From Patients With Fallot’S Tetralogy
Authors: Guanggen Cui, Joseph Perloff, Mark Plunkett, Hillel Laks, Luyi Sen
Journal: Circulation (2007)

Matrix metalloproteinases (MMPs) is a family of enzymes for extracellular matrix degradation that has been know to play an important role in the disease-related vascular remodeling, however, its pr...
Atrophia maculosa varioliformis cutis
Authors: Steven A. Kolenik, Maritza I. Perez, Diane M. Davidson, Greg S. Morganroth, Steven R. Kohn, Jean L. Bolognia
Journal: Journal of the American Academy of Dermatology (1994)

Atrophia maculosa varioliformis cutis was initially described in 1918 as an entity in which both linear and punctate scars appeared spontaneously on normal facial skin. To the best of our knowledge, only five additional cases have been described. We describe two patients, 14 and 20 years of age, whose histories and clinical lesions fit the description of atrophia maculosa varioliformis cutis. The histologic findings are also described, and the literature to date is reviewed.
Abstract 3406: Completely Autologous Valved-Conduit With the Sinus of Valsalva (BIOVALVEs) Constructed by in vivo-Tissue Engineering: Successful Pulmonary Valve Replacement in Beagle Model
Authors: Masashi Yamanami, Yuki Yahata, Megumi Fujiwara, Tsutomu Tajikawa, Taiji Watanabe, Keiichi Kanda, Hitoshi Yaku, Masami Uechi, Yasuhide Nakayama
Journal: Circulation (2009)
Abstract 2667: Aspiration Coronary Thrombectomy for Acute Myocardial Infarction Improves Myocardial Salvage Index. Single Center Randomized Study
Authors: Michal Ciszewski, Jerzy Pregowski, Anna Teresinska, Maciej Karcz, Witold Ruzyllo
Journal: Circulation (2008)

Primary percutaneus intervention (pPCI) is a recommended treatment strategy for acute myocardial infarction with ST segment elevation (STEMI). Adjunctive thrombectomy may add clinical benefits. The aim of our study was to compare the efficacy of aspiration thrombectomy versus standard pPCI for STEMI. The primary endpoint was salvage index assessed by sestamibi SPECT perfusion imaging. Single centre randomized study on aspiration thrombectomy in acute STEMI. 135 patients (88 males, mean age 64,3±12,4 yrs) with first acute STEMI were enrolled between Nov 2004 and Dec 2007. Inclusion criteria were: first anterior or inferior STEMI within 12 hours from pain onset with culprit lesion in left anterior descending (LAD) or right coronary artery (RCA) and TIMI flow ≤ 2. Patients were randomly assigned to thrombectomy with Rescue or Diver device followed by stent implantation (65) vs. standard pPCI with stenting (70 pts). 5 patients initially randomised to thrombectomy were finally treated with standard pPCI. Two SPECT examinations were performed: before and 5– 8 days after reperfusion therapy. Five patients died 3–7 days after the procedure, and in 3 pts second SPECT could not be performed because of patients’ severe condition. Thus two SPECT examinations were performed in 127 patients (63 treated with thrombectomy and 64 in control group). These 127 subject were the basis of the intention to treat analyses. There were 41 pts with anterior STEMI and 86 pts with inferior STEMI. Both treatment groups were similar regarding baseline demographic and clinical variables. Based on the SPECT perfusion imaging results, the final infarct size was assessed and myocardial salvage index (proportion of the myocardium at risk salvaged by reperfusion) was calculated. Baseline myocardium at risk area was 35,0%±2,8% in thrombectomy group vs 35,8%±10,9% in control patients. (p=NS). Myocardial salvage index was larger in patients treated with aspiration thrombectomy (0,33±0,27 vs. 0,20 ± 0,21 p = 0,004). Moreover, final infarct size was significantly smaller in patients treated with thrombectomy: 23,9% ± 13,1 % vs.28,3 % ±9,6% p = 0,005. Our results show that coronary thrombectomy is beneficial as an adjunctive therapy to pPCI in STEMI.
Abstract 16118: The Presence of the Mother DNA Identifies a Cardiac Stem Cell Class Which Promotes a Remarkable Recovery of the Infarcted Heart
Authors: Donato Cappetta, Yingnan Bai, Domenico D'Amario, Hanqiao Zheng, Claudia Fiorini, Alex Matsuda, Barbara Ogorek, James Kostyla, Virginia Caballero, Marcello Rota, Joao Ferreira-Martins, David A D'Alessandro, Robert E Michler, Annarosa Leri, Jan Kajstura, Roberto Bolli, Piero Anversa
Journal: Circulation (2011)

The immortal strand theory defines two categories of human cardiac stem cells (hCSCs), which self-renew by non-random and random segregation of chromatids, respectively. We have employed single cel...
Safety of Transvenous Cardiac Resynchronization System Implantation in Patients With Chronic Heart Failure
Authors: Angel R. León, William T. Abraham, Anne B. Curtis, James P. Daubert, Westby G. Fisher, John Gurley, David L. Hayes, Randy Lieberman, Susan Petersen-Stejskal, Kevin Wheelan
Journal: Journal of the American College of Cardiology (2005)
The role of public health officers in preparedness planning and management of health crises
Authors: R Strauss, R Muchl, M Kunze, H Hrabcik
Journal: Eurosurveillance (2008)

The contribution of public health officers is of crucial importance in both the preparedness planning process and the response to health threats since the implementation of public health measures lies within the competence of the public health system. Thus, public health officers on regional and district level have to be involved in every stage of the planning process for crisis management. Federal structures of health systems as equivalent to the political structure of a country pose specific challenges for both the planning process and the response itself. The most important instrument for the evaluation of crisis plans, including the assessment of the public health officers' preparedness, is the performance of exercises. The success of a simulation exercise depends mainly on careful planning process, clear evaluation criteria and a work plan, that allows for necessary improvements of crisis plans of all involved organisations. Simulation exercises are an integrated element of preparedness activities on all administrative levels of the public health system. Depending on the nature of the exercise public health officers on regional and district level are involved as planners or as players
Response of patients with treatment-refractory schizophrenia to clozapine within three serum level ranges
Authors: C VanderZwaag, M McGee, J P McEvoy, O Freudenreich, W H Wilson, T B Cooper
Journal: American Journal of Psychiatry (1996)

This study sought to determine the relationships between serum clozapine levels and therapeutic response.Fifty-six inpatients who met the DSM-III-R criteria for chronic schizophrenia and who had not responded to extended treatment with classical antipsychotics were randomly assigned to 12 weeks of double-blind treatment with clozapine at one of three serum level ranges: low (50-150 ng/ml), medium (200-300 ng/ml), or high (350-450 ng/ml). Baseline clinical assessments were completed before the patients' regular antipsychotic and anticholinergic drugs were discontinued. During clozapine treatment, serum levels were ascertained weekly to allow adjustment of clozapine doses so as to maintain each patient near the midpoint of his or her assigned serum level range. Clinical assessments were completed after 6 and 12 weeks of treatment.The analyses of the results of treatment supported the superior efficacy of the 200-300 ng/ml and 350-450 ng/ml serum clozapine level ranges over the 50-150 ng/ml range, with no advantage for 350-450 ng/ml over 200-300 ng/ml. Sleepiness increased with increasing serum levels.Serum clozapine levels per unit of daily dose were at the lower end of the range noted in previous reports, possibly reflecting the current study's dosing schedules of twice or three times a day, the 11- to 13-hour postdose sampling time, and the moderate doses given. Serum clozapine levels, if interpreted in relation to daily clozapine dosing schedules, postdose sampling time, and total daily dose, may help to guide dosing to provide adequate opportunities for therapeutic response and to limit certain side effects of clozapine treatment.
Spot Diagnosis
Authors: Zornitza Stark, Lynda J. Campbell, Catherine Mitchell, Paul A. James, John A. Heath, Alex Boussioutas, Craig Lynch, Alison H. Trainer
Journal: New England Journal of Medicine (2014)

A clinical scenario is described in which skin findings were the clue to a familial cancer-predisposition disorder and led to the early diagnosis of a potentially fatal disease in a sibling of the index patient.
Abstract 11828: Culprit Only versus Complete Coronary Revascularization During Primary PCI
Authors: Daud Karawani, Hillel Steiner, Menachem Nahir, Aviva Peleg, Yonathan Hasin
Journal: Circulation (2011)

Background: Current guidelines for management of patients with ST elevation myocardial infarction (STEMI) recommend treating only the culprit vessel in multivessel disease and that other vessels be addressed at a later procedure. Acute multivessel PCI (MVPCI) is recommended during the index procedure only for patients with hemodynamic compromise. Objectives: The purpose of this study was to examine differences in in-hospital clinical outcomes as well as short term and 1 year mortality for STEMI patients with multivessel disease as a function of whether they underwent culprit vessel or MVPCI. Methods: STEMI patients with multivessel disease undergoing primary PCIs between January 2001, and September 2010, were divided into those who underwent culprit vessel PCI (CVPCI) alone and those who underwent MVPCI during the index procedure. In-hospital adverse outcomes and mortality rates were compared. Results: A total of 453 patients had multivessel disease. In 318 (70.2%) of them MVPCI was performed during the i...
Abstract 19093: Assessing the Predictive Value of Traditional Risk Factors for Coronary Artery Disease Severity and Plaque Morphology on Coronary Computed Tomography Angiography: Individual vs Population
Authors: Amir A Ahmadi, Mark Chandy, Saman Rezazadeh, Brett Heilbron, Jonathon Leipsic, Krishnan Ramanathan, Carolyn Taylor
Journal: Circulation (2010)

Objectives: To assess the predictive value of traditional cardiac risk factors (CRFs) for coronary artery disease (CAD) burden and plaque morphology (PM) as reported by Coronary CT Angiography (CCT...
Postictal and chronic psychoses in patients with temporal lobe epilepsy
Authors: D Umbricht, G Degreef, W B Barr, J A Lieberman, S Pollack, N Schaul
Journal: American Journal of Psychiatry (1995)

This study sought to elucidate the relation of clinical, neuropsychological, and seizure variables to chronic and postictal psychoses in patients with temporal lobe epilepsy.Forty-four patients with treatment-refractory temporal lobe epilepsy were given formal psychiatric evaluations; 29 patients had no psychiatric disorder or a nonpsychotic disorder, eight patients had postictal psychoses, and seven patients had chronic psychoses. Comparisons of clinical, neuropsychological, magnetic resonance imaging, and seizure variables were made between the nonpsychotic and the psychotic patients and, secondarily, between the patients with transient postictal psychoses and those with chronic psychoses.Bitemporal seizure foci, clustering of seizures, and absence of febrile convulsions were associated with both postictal psychoses and chronic psychoses. Younger age at onset of epilepsy and lower verbal and full-scale IQs differentiated the patients with chronic psychoses from those with postictal psychoses.Patients with temporal lobe epilepsy with chronic and postictal psychoses show similar profiles of clinical and seizure variables, suggesting shared etiologic factors. These factors may increase the propensity to develop psychotic symptoms, while other factors, such as time of onset of epilepsy and underlying neuropathology, may determine whether transient or chronic psychotic symptoms develop. Even among patients with treatment-refractory temporal lobe epilepsy, a specific subgroup of patients, characterized by bitemporal seizure foci, an absence of febrile convulsions, and a history of clustering of seizures, appears to be particularly prone to develop psychotic disorders. A process similar to secondary epileptogenesis may be involved in the development of the psychoses.
Wong should join Junior Doctors' Committee
Authors: S J Krikler
Journal: BMJ (1995)

the reduction was to only 83 hours a week.Furthermore, although we included some of the more benign comments of the trainees in our article, many of them, though entertaining, were unprintable.We agree that the Junior Doctors Committee (which allegedly disbelieved our data) is out of touch with the wishes of many junior staff, particularly surgical trainees.Perish the thought that we should shorten our hours to the levels in Europe.For example, in Denmark (where they have a 37 hour week), on a urological unit a little bigger than ours there are eight senior registrars.The trainee who covers a weekend has to have the whole of the next week off.Surely even the Junior Doctors Committee cannot believe that this is compatible with an adequate training programme.One of the great advantages of consultant practice in Britain is personal autonomy (though this also is under threat).This requires a higher level of exposure and experience than is needed by our counterparts in Europe, who are more protected.
Website of the Week: SARS art
Authors: Trevor Jackson
Journal: BMJ (2003)

As we have pointed out in previous columns, severe acute respiratory syndrome (SARS) is very much an epidemic of the internet age (http://bmj.com/cgi/content/full/326/7395/937/a and http://bmj.com/cgi/content/full/326/7399/1152-a). But information and data about cases, symptoms, and treatment are not the only SARS related material online. The outbreak has also spawned much digital folk art.​art.




Figure 1




The SARS Art Project (www.sarsart.org/) is evidence of how much the epidemic has captured the popular imagination, particularly at the height of media attention over the disease. The site, which began as a series of posts on the weblog BoingBoing.net (“a collection of wonderful things”), features a range of “found” and original images, “online oddities that demonstrated the epidemic's social impact throughout the blogosphere.”

Judging from most of the contributions from BoingBoing readers and net artists, it is clear that the mask is to SARS what the condom is to AIDS. Many of the artworks feature masks, from couture creations from the Philippines (www.inq7.net/lif/2003/apr/06/lif_8-1.htm) to a parody ad for a Michael Jackson style SARS mask (www.xeni.net/images/boingboing/sars/misc/terre.jpg), and even a surgical mask design for the Star Wars character Darth Vader (www.tkblog.com/pics/linked/darthsarsmask.jpg). Among the more striking images are SARS! (pictured), by net artist Katie Bush, and one of gods posted on doors in ancient (and modern) China to ward off evil spirits and “kick demon ass” (www.sarsart.org/sars-ghi.php).

Xeni Jardin, who has created the SARS Art Project, says, “Online art and weblogs are cheap, instant, and capable of reaching millions worldwide.” She adds, “They make what's global, personal; what's personal, global.”
Ethical Issues in Sex Therapy and Research.
Authors: Beryl A. Chernick
Journal: Annals of Internal Medicine (1977)

thor, Meizack), neuroaugmentation, neuromodulation and brain stimulation effects on pain.The special roles of the anesthesiologist, nurse and neurosurgical physician's assistant in the treatment of intractable pain are presented in an informative and useful way.This monograph will be of value and of stimulating interest to basic and clinical scientists, physicians, dentists, nurses, sociologists, biomedical engineers and other health professionals who are interested in pain therapy.It provides a valuable re- view for residents in training wishing to gain insight into the current management of pain.
Abstract 9065: Dose-Dependent Rescue Effects by a Desensitizing TnI Molecule in a RCM Mouse Model
Authors: Pierre-Yves Jean-Charles, Yuejin Li, Changlong Nan, Guozhen Chen, Han-Zhong Feng, Jian-Ping Jin, Xupei Huang
Journal: Circulation (2011)

We have previously demonstrated that the R193H mutation of cardiac troponin I (cTnI) caused restrictive cardiomyopathy (RCM) and early death in transgenic mice (Du et al., 2006). RCM mutants are also characterized by increased myofilament Ca 2+ sensitivity and impaired cardiac relaxation (Gomes et al., 2005; Du et al., 2008). Restrictive cleavage of the N-terminal extension of cTnI has been shown to desensitize myofilament to Ca 2+ and enhance diastolic function in transgenic mice (Yu et al., 2001; Feng et al., 2008; McConnell et al., 2009). N-terminal truncated cTnI (cTnI-ND) also had the ability to correct the diastolic dysfunction and increase the lifespan of RCM mice expressing the cTnI R193H mutant in a wild type cTnI null background (Li et al, 2010). In the present study, we produced double transgenic mice (Double-TG) expressing different levels of mutant cTnI R193H and cTnI-ND to investigate the dose-dependent rescue effect of cTnI-ND and determine the mechanisms behind its protective role in young and aged RCM mice. In 2-month-old Double-TG mice, the rescue of these animals is secondary to the desensitization of their myofilament to Ca 2+ and the fixing of their cardiac relaxation impairment by cTnI-ND. The correction of the diastolic dysfunction by cTnI-ND occurs in a dose-dependent manner as evidenced by cell-based assays, measuring cardiac cell contractility of the various Double-TG mouse lines, and by echocardiography. In addition, in 8-10-month-old Double-TG mice, the rescue of RCM mice by cTnI-ND is characterized by both the restoration of their diastolic function and the amelioration of their systolic function, since both diastolic and systolic functions deteriorate in aged RCM mice. Thus, this study allows determining the efficiency of cTnI-ND in the treatment of RCM and evaluating how the dosage of RCM mutant proteins may influence the cardiac function. Also, consistent with the beneficial effect of cTnI-ND on the function of non-myopathic aging hearts (Biesiadescki et al., 2010), these data demonstrate the ability of cTnI-ND to rescue the RCM phenotype not only by correcting diastolic dysfunction in young RCM mice, but also by improving systolic function in aged RCM mice.
Abstract 4173: Adenosine Stress Dual-Energy CT of the Heart for Diagnosing Myocardial Ischemia and Viability Compared with Cardiac MRI and SPECT: Initial Experience
Authors: Balazs Ruzsics, Peter L Zwerner, Salvatore Chiaramida, Joseph A Abro, Sebastian Vogt, Philip Costello, U. Joseph Schoepf
Journal: Circulation (2008)
Abstract 19345: Psoriasis Early Affects Coronary Flow Reserve: New Insights Into Coronary Microvascular Dysfunction and Inflammation.
Authors: Elena Osto, Stefano Piaserico, Anna Maddalozzo, Giulia Forchetti, Andrea Peserico, Sabino Iliceto, Francesco Tona
Journal: Circulation (2010)

Background:Psoriasis (Ps) is a recently recognized independent determinant for myocardial infarction (MI), associated with cardiovascular risk factors.We investigated whether coronary flow reserve (CFR), an index of coronary microvascular function, was impaired in young patients with Ps and the relationship between clinical markers of Ps activity and coronary blood flow abnormalities. Methods: 56 patients (pts) with Ps (42 M, aged 37±7 years) without clinical evidence of heart diseases, and 48 controls matched for age and sex were studied. Coronary flow velocity in the left anterior descending coronary artery was detected by transthoracic Doppler echocardiography at rest and during adenosine infusion. CFR was the ratio of hyperaemic diastolic flow velocity (DFV) to resting DFV. A CFR ≤2.5 was considered abnormal. Mean time from diagnosis of Ps was 17±7 years. Results: In pts with Ps, CFR was lower than in controls (3.2±0.9 vs 3.7±0.7, p=0.02). CFR was abnormal (≤2.5) in 12 pts with Ps (22% vs 0% controls,...
A Modified Dose Intensive R- CODOX-M/IVAC For HIV-Associated Burkitt and Atypical Burkitt Lymphoma(BL) Demonstrates High Cure Rates and Low Toxicity: Prospective Multicenter Phase II Trial Of The AIDS Malignancy Consortium (AMC 048)
Authors: Ariela Noy, Lawrence Kaplan, Jeannette Y Lee
Journal: Blood (2013)