tbuckley/cabot-search huggingface dataset:
US Liver Transplant Outcomes After Normothermic Regional Perfusion vs Standard Super Rapid Recovery
Authors: Aleah L. Brubaker, Marty T. Sellers, Peter L. Abt, Kristopher P. Croome, Shaheed Merani, Anji Wall, Phillipe Abreu, Musab Alebrahim, Roy Baskin, Humberto Bohorquez, Robert M. Cannon, Kelly Cederquist, John Edwards, Benjamin G. Huerter, Mark J. Hobeika, Lori Kautzman, Alan N. Langnas, David D. Lee, Joao Manzi, Ahmed Nassar, Nikole Neidlinger, Trevor L. Nydam, Gabriel T. Schnickel, Farjad Siddiqui, Ashley Suah, Raeda Taj, C. Burcin Taner, Giuliano Testa, Rodrigo Vianna, Frederick Vyas, Martin I. Montenovo
Journal: JAMA Surgery (2024)

Normothermic regional perfusion (NRP) is an emerging recovery modality for transplantable allografts from controlled donation after circulatory death (cDCD) donors. In the US, only 11.4% of liver recipients who are transplanted from a deceased donor receive a cDCD liver. NRP has the potential to safely expand the US donor pool with improved transplant outcomes as compared with standard super rapid recovery (SRR).
Astrocyte-secreted neurocan controls inhibitory synapse formation and function
Authors: Dolores Irala, Shiyi Wang, Kristina Sakers, Leykashree Nagendren, Francesco Paolo Ulloa Severino, Dhanesh Sivadasan Bindu, Justin T. Savage, Cagla Eroglu
Journal: Neuron (2024)

Astrocytes strongly promote the formation and maturation of synapses by secreted proteins. Several astrocyte-secreted synaptogenic proteins controlling excitatory synapse development were identified; however, those that induce inhibitory synaptogenesis remain elusive. Here, we identify neurocan as an astrocyte-secreted inhibitory synaptogenic protein. After secretion from astrocytes, neurocan is cleaved into N- and C-terminal fragments. We found that these fragments have distinct localizations in the extracellular matrix. The neurocan C-terminal fragment localizes to synapses and controls cortical inhibitory synapse formation and function. Neurocan knockout mice lacking the whole protein or only its C-terminal synaptogenic domain have reduced inhibitory synapse numbers and function. Through super-resolution microscopy, in vivo proximity labeling by secreted TurboID, and astrocyte-specific rescue approaches, we discovered that the synaptogenic domain of neurocan localizes to somatostatin-positive inhibitory synapses and strongly regulates their formation. Together, our results unveil a mechanism through which astrocytes control circuit-specific inhibitory synapse development in the mammalian brain.
A Gelatin/Alginate Double Network Hydrogel Nerve Guidance Conduit Fabricated by a Chemical‐Free Gamma Radiation for Peripheral Nerve Regeneration
Authors: Junghyun Kim, Junggeon Park, Goeun Choe, Sung‐In Jeong, Hyung‐Seok Kim, Jae Young Lee
Journal: Advanced Healthcare Materials (2024)

Abstract Nerve guidance conduits (NGCs) are widely developed using various materials for the functional repair of injured or diseased peripheral nerves. Especially, hydrogels are considered highly suitable for the fabrication of NGCs due to their beneficial tissue‐mimicking characteristics (e.g., high water content, softness, and porosity). However, the practical applications of hydrogel‐based NGCs are hindered due to their poor mechanical properties and complicated fabrication processes. To bridge this gap, a novel double‐network (DN) hydrogel using alginate and gelatin by a two‐step crosslinking process involving chemical‐free gamma irradiation and ionic crosslinking, is developed. DN hydrogels (1% alginate and 15% gelatin), crosslinked with 30 kGy gamma irradiation and barium ions, exhibit substantially improved mechanical properties, including tensile strength, elastic modulus, and fracture stain, compared to single network (SN) gelatin hydrogels. Additionally, the DN hydrogel NGC exhibits excellent kink resistance, mechanical stability to successive compression, suture retention, and enzymatic degradability. In vivo studies with a sciatic defect rat model indicate substantially improved nerve function recovery with the DN hydrogel NGC compared to SN gelatin and commercial silicone NGCs, as confirm footprint analysis, electromyography, and muscle weight measurement. Histological examination reveals that, in the DN NGC group, the expression of Schwann cell and neuronal markers, myelin sheath, and exon diameter are superior to the other controls. Furthermore, the DN NGC group demonstrates increased muscle fiber formation and reduced fibrotic scarring. These findings suggest that the mechanically robust, degradable, and biocompatible DN hydrogel NGC can serve as a novel platform for peripheral nerve regeneration and other biomedical applications, such as implantable tissue constructs.
Author Correction: A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas
Authors: Leandro. C Cerchietti, Eloisi. C Lopes, Shao. Ning Yang, Katerina Hatzi, Karen. L Bunting, Lucas. A Tsikitas, Alka Mallik, Ana. I Robles, Jennifer Walling, Lyuba Varticovski, Rita Shaknovich, Kapil. N Bhalla, Gabriela Chiosis, Ari Melnick
Journal: Nature Medicine (2024)
Strengthening Latin America’s presence in global health
Authors: Deisy Ventura, Miguel O’Ryan
Journal: BMJ (2024)

In recent decades, Latin America has made important contributions to global health.Although substantial economic and social inequalities and political instability continue to adversely affect population health, the region is developing knowledge, health policies, and experience that deserve wider recognition.Contributions include Latin America's efforts in social medicine, especially in social security and nutrition 1 ; national public policies that have become a world reference, such as the compulsory licensing of an AIDS drug in Brazil in 2007 2 ; and the health cooperation agenda intended to create a platform for solidarity focusing on infrastructure, health, security, and natural resources within the framework of the now dissolved Union of South American Nations. 3ilding on these contributions, and to help boost the region's profile and leadership in global health, The BMJ has established its first regional advisory board for Latin America, as part of its wider regional advisory board programme. 4We began work in late 2023 with a focus on identifying common themes and issues in countries within the region to advance collective efforts for health.
GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14
Authors: Qianjin Liu, Lijin Jiao, Mao-Sen Ye, Zhiyu Ma, Jinsong Yu, Ling-Yan Su, Wei-Yin Zou, Lu-Xiu Yang, Chang Chen, Yong-Gang Yao
Journal: Cellular and Molecular Immunology (2024)
Sex dimorphisms in coagulation: Implications in trauma‐induced coagulopathy and trauma resuscitation
Authors: Julia R. Coleman, Richard Gumina, Thomas Hund, Mitchell Cohen, Matthew D. Neal, Kristy Townsend, Bryce A. Kerlin
Journal: American Journal of Hematology (2024)

Trauma-induced coagulopathy (TIC) is one of the leading causes of preventable death in injured patients. Consequently, it is imperative to understand the mechanisms underlying TIC and how to mitigate this mortality. An opportunity for advancement stems from the awareness that coagulation demonstrates a strong sex-dependent effect. Females exhibit a relative hypercoagulability compared to males, which persists after injury and confers improved outcomes. The mechanisms underlying sex dimorphisms in coagulation and its protective effect after injury have yet to be elucidated. This review explores sex dimorphisms in enzymatic hemostasis, fibrinogen, platelets, and fibrinolysis, with implications for resuscitation of patients with TIC.
Re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of 99mTc-Sestamibi Single-photon Emission Computed Tomography/Computed Tomography in the Diagnostic Pathway for Renal Masses: A Systematic Review and Meta-analysis. Eur Urol 2024;85:63–71
Authors: Angela Estevez, Phillip Kim, Peter Chang, Andrew A. Wagner
Journal: European Urology (2024)
Re: Marc-Oliver Grimm, Mototsuga Oya, Toni K. Choueiri, et al. Impact of Prior Cytoreductive Nephrectomy on Efficacy in Patients with Synchronous Metastatic Renal Cell Carcinoma Treated with Avelumab plus Axitinib or Sunitinib: Post Hoc Analysis from the JAVELIN Renal 101 Phase 3 Trial. Eur Urol 2024;85:8–12
Authors: Michael Froehner
Journal: European Urology (2024)
Reply to Angela Estevez, Phillip Kim, Peter Chang, and Andrew A. Wagner’s Letter to the Editor re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of 99mTc-Sestamibi Single-photon Emission Computed Tomography/Computed Tomography in the Diagnostic Pathway for Renal Masses: A Systematic Review and Meta-analysis. Eur Urol 2024;85:63–71
Authors: Giuseppe Basile, Alessandro Larcher, Arturo Chiti, Alberto Breda, Umberto Capitanio
Journal: European Urology (2024)
Intense 18F-FAPI Uptake in Small Recurrent Lesions of Combined Hepatocellular-Cholangiocarcinoma Negative on 18F-FDG PET/CT
Authors: Jiucen Liang, Jing Zhang, Jingjing Song, Rusen Zhang, Linqi Zhang
Journal: Clinical Nuclear Medicine (2024)

A 70-year-old man presented with combined hepatocellular-cholangiocarcinoma underwent partial hepatectomy and chemoradiotherapy approximately 3 months ago. Follow-up abdominal ultrasound detected a new small lesion with decreased echogenicity in the hepatic segment I, potentially indicating recurrence. The patient was enrolled in a clinical trial of comparison of 18 F-FDG and 18 F-FAPI PET/CT in hepatic lesions. Compared with non- 18 F-FDG avidity, 18 F-FAPI PET/CT showed intense tracer uptake of the hepatic lesion. Resection of the lesion was subsequently performed, and pathologic analysis confirmed the diagnosis of recurrent combined hepatocellular-cholangiocarcinoma.
Viral shedding and viraemia of Andes virus during acute hantavirus infection: a prospective study
Authors: Marcela Ferrés, Constanza Martínez-Valdebenito, Carolina Henriquez, Claudia Marco, Jenniffer Angulo, Aldo Barrera, Carlos Palma, Gonzalo Barriga Pinto, Analia Cuiza, Leonila Ferreira, María Luisa Rioseco, Mario Calvo, Ricardo Fritz, Sebastián Bravo, Alejandro Bruhn, Jerónimo Graf, Alvaro Llancaqueo, Gonzalo Rivera, Carolina Cerda, Nicole Tischler, Francisca Valdivieso, Pablo Vial, Gregory Mertz, Cecilia Vial, Nicole Le Corre
Journal: The Lancet Infectious Diseases (2024)
Advancing disability-inclusive climate research and action, climate justice, and climate-resilient development
Authors: Penelope J S Stein, Michael Ashley Stein, Nora Groce, Maria Kett, Emmanuel K Akyeampong, Willliam P Alford, Jayajit Chakraborty, Sheelagh Daniels-Mayes, Siri H Eriksen, Anne Fracht, Luis Gallegos, Shaun Grech, Pratima Gurung, Asha Hans, Paul Harpur, Sébastien Jodoin, Janet E Lord, Setareki Seru Macanawai, Charlotte V McClain-Nhlapo, Benyam Dawit Mezmur, Rhonda J Moore, Yolanda Muñoz, Vikram Patel, Phuong N Pham, Gerard Quinn, Sarah A Sadlier, Carmel Shachar, Matthew S Smith, Lise Van Susteren
Journal: The Lancet Planetary Health (2024)

Globally, more than 1 billion people with disabilities are disproportionately and differentially at risk from the climate crisis. Yet there is a notable absence of climate policy, programming, and research at the intersection of disability and climate change. Advancing climate justice urgently requires accelerated disability-inclusive climate action. We present pivotal research recommendations and guidance to advance disability-inclusive climate research and responses identified by a global interdisciplinary group of experts in disability, climate change, sustainable development, public health, environmental justice, humanitarianism, gender, Indigeneity, mental health, law, and planetary health. Climate-resilient development is a framework for enabling universal sustainable development. Advancing inclusive climate-resilient development requires a disability human rights approach that deepens understanding of how societal choices and actions—characterised by meaningful participation, inclusion, knowledge diversity in decision making, and co-design by and with people with disabilities and their representative organisations—build collective climate resilience benefiting disability communities and society at large while advancing planetary health.
Intersectional climate justice, health equity, and HIV
Authors: Sarah M Wilson, Griffin Woolley, Chris Hawn, Kate Hoffman, Akhenaton-Andrew D Jones, Cliburn Chan, Sarah V Mudrak, M Umar Qureshi, Ashley Ward, Elizabeth T Knippler, N Lance Okeke, Amy Corneli, Georgia D Tomaras, R Keith Reeves
Journal: The Lancet HIV (2024)
A critical review of the effectiveness of electric fans as a personal cooling intervention in hot weather and heatwaves
Authors: Robert D Meade, Sean R Notley, Nathalie V Kirby, Glen P Kenny
Journal: The Lancet Planetary Health (2024)

Health agencies worldwide have historically cautioned that electric fans accelerate body-heat gain during hot weather and heatwaves (typically in air temperatures ≥35°C). However, guidance published since 2021 has suggested that fans can still cool the body in air temperatures up to 40°C by facilitating sweat evaporation, and therefore are an inexpensive yet sustainable alternative to air conditioning. In a critical analysis of the reports cited to support this claim, we found that although fan use improves sweat evaporation, these benefits are of insufficient magnitude to exert meaningful reductions in body core temperature in air temperatures exceeding 35°C. Health agencies should continue to advise against fan use in air temperatures higher than 35°C, especially for people with compromised sweating capacity (eg, adults aged 65 years or older). Improving access to ambient cooling strategies (eg, air conditioning or evaporative coolers) and minimising their economic and environmental costs through policy initiatives, efficient cooling technology, and combined use of low-cost personal interventions (eg, skin wetting or fan use) are crucial for climate adaptation.
Cities, planetary boundaries, and degrowth
Authors: Jakub Kronenberg, Erik Andersson, Thomas Elmqvist, Edyta Łaszkiewicz, Jin Xue, Yaryna Khmara
Journal: The Lancet Planetary Health (2024)

Cities are the main hubs of human activity and the engines of economic growth. In pursuit of such growth, cities are transgressing their local environmental boundaries. Ongoing urbanisation increasingly contributes to the human pressure on planetary boundaries and negatively affects planetary health. In a telecoupled world, cities externalise impacts by shifting production and many other functions away from their boundaries. At the same time, urban inhabitants and people who follow urban lifestyles but live outside cities are increasingly disconnected from nature. This Viewpoint highlights the role of degrowth in keeping an urban planet within planetary boundaries and suggests areas for further research and policy. Degrowth calls for meaningfully connecting planetary boundaries with cities and ensuring everyone receives a fair share of their ecological capacity. Degrowth calls for lower use of existing resources, highlights political power asymmetries, and moves beyond pricing interventions. Degrowth addresses three key aspects that connect cities and urban lifestyles to planetary boundaries: reducing production and consumption, connecting people and nature, and including nature (to a more substantial extent) in the design of cities and in what is used and consumed in cities. A radical degrowth transformation of cities is necessary to stay within a safe operating space for humanity.
3-year invasive disease-free survival with chemotherapy de-escalation using an 18F-FDG-PET-based, pathological complete response-adapted strategy in HER2-positive early breast cancer (PHERGain): a randomised, open-label, phase 2 trial
Authors: José Manuel Pérez-García, Javier Cortés, Manuel Ruiz-Borrego, Marco Colleoni, Agostina Stradella, Begoña Bermejo, Florence Dalenc, Santiago Escrivá-de-Romaní, Lourdes Calvo Martínez, Nuria Ribelles, Frederik Marmé, Alfonso Cortés, Cinta Albacar, Geraldine Gebhart, Aleix Prat, Khaldoun Kerrou, Peter Schmid, Sofia Braga, Serena Di Cosimo, Maria Gion, Gabriele Antonarelli, Crina Popa, Emilia Szostak, Daniel Alcalá-López, Petra Gener, Jose Rodríguez-Morató, Leonardo Mina, Miguel Sampayo-Cordero, Antonio Llombart-Cussac
Journal: The Lancet (2024)
Submucosal tunneling endoscopic resection in retroflexion for gastric gastrointestinal stromal tumor of the fundus
Authors: Georgios Mavrogenis, Marinos Chatzis, Anna Spanomanoli, Loukas Kaklamanis, Fateh Bazerbachi
Journal: Endoscopy (2024)

Endoscopic resection of gastrointestinal stromal tumors of the fundus is challenging due to the need for full-thickness resection and the difficulties of defect closure. Submucosal tunneling under direct view through the esophagus can be carried out for esophageal tumors and gastric tumors of the cardia near the gastroesophageal junction. However, for tumors located at the fundus this is not feasible. In this video ([Video 1]), we present the resection strategy for a gastric gastrointestinal stromal tumor (GIST) located at the fundus ([Fig. 1]), utilizing submucosal tunneling endoscopic resection (STER) in retroflexion combined with clip-and-band traction, together with clip-and-loop closure of the mucosal defect.
Striving for a climate-resilient future
Authors: Shilu Tong, Hilary Bambrick, Kristie L Ebi
Journal: The Lancet Planetary Health (2024)

A wide-reaching concern in planetary health is: can we strive for a climate resilient future? The 28th Conference of the Parties (COP28) of the UN Framework Convention on Climate Change took place in Dubai in the United Arab Emirates from Nov 30, to Dec 13, 2023.1 At a time when conflicts elsewhere in the world have dominated the news, we must not lose sight of the fact that the outcomes of the COP28 negotiations are crucial for building a climate resilient society and ensuring the achievement of the Paris climate goals, which include keeping increases in global mean surface temperatures well below 2°C in this century relative to pre-industrial levels and advancing timely, effective, and sustainable adaptation to climate impacts.
Ring-string traction for successful endoscopic clip closure to treat delayed perforation of the ulcer bed after colorectal endoscopic submucosal dissection
Authors: Rie Tsukida, Yoshihiro Kishida, Kenichiro Imai, Kazunori Takada, Sayo Ito, Kinichi Hotta, Hiroyuki Ono
Journal: Endoscopy (2024)

Endoscopic closure of delayed perforations after colorectal endoscopic submucosal dissection (ESD) is challenging due to the fragility of the ulcer bed and the stiffness of the surrounding tissue [1] [2] [3] [4]. The case presented here illustrates closure of an ulcer bed with delayed perforation after ESD by endoscopic mucosa-to-mucosa closure using a ring-string traction ([Fig. 1]; [Video 1]).
Implementation Science to Achieve Equity in Heart Failure Care: A Scientific Statement From the American Heart Association
Authors: Khadijah Breathett, Sabra Lewsey, Nicholas K. Brownell, Kendra Enright, Lorraine S. Evangelista, Nasrien E. Ibrahim, Jose Iturrizaga, Daniel D. Matlock, Modele O. Ogunniyi, Madeline R. Sterling, Harriette G.C. Van Spall
Journal: Circulation (2024)

Guideline-directed medical therapies and guideline-directed nonpharmacological therapies improve quality of life and survival in patients with heart failure (HF), but eligible patients, particularly women and individuals from underrepresented racial and ethnic groups, are often not treated with these therapies. Implementation science uses evidence-based theories and frameworks to identify strategies that facilitate uptake of evidence to improve health. In this scientific statement, we provide an overview of implementation trials in HF, assess their use of conceptual frameworks and health equity principles, and provide pragmatic guidance for equity in HF. Overall, behavioral nudges, multidisciplinary care, and digital health strategies increased uptake of therapies in HF effectively but did not include equity goals. Few HF studies focused on achieving equity in HF by engaging stakeholders, quantifying barriers and facilitators to HF therapies, developing strategies for equity informed by theory or frameworks, evaluating implementation measures for equity, and titrating strategies for equity. Among these HF equity studies, feasibility was established in using various educational strategies to promote organizational change and equitable care. A couple include ongoing randomized controlled pragmatic trials for HF equity. There is great need for additional HF implementation trials designed to promote delivery of equitable guideline-directed therapy.
The role of quality of life data as an endpoint for collecting real-world evidence within geroscience clinical trials
Authors: Girish Harinath, Sajad Zalzala, Andy Nyquist, Maartje Wouters, Anar Isman, Mauricio Moel, Eric Verdin, Matt Kaeberlein, Brian Kennedy, Evelyne Bischof
Journal: Ageing Research Reviews (2024)

With geroscience research evolving at a fast pace, the need arises for human randomized controlled trials to assess the efficacy of geroprotective interventions to prevent age-related adverse outcomes, disease, and mortality in normative aging cohorts. However, to confirm efficacy requires a long-term and costly approach as time to the event of morbidity and mortality can be decades. While this could be circumvented using sensitive biomarkers of aging, current molecular, physiological, and digital endpoints require further validation. In this review, we discuss how collecting real-world evidence (RWE) by obtaining health data that is amenable for collection from large heterogeneous populations in a real-world setting can help speed up validation of geroprotective interventions. Further, we propose inclusion of quality of life (QoL) data as a biomarker of aging and candidate endpoint for geroscience clinical trials to aid in distinguishing healthy from unhealthy aging. We highlight how QoL assays can aid in accelerating data collection in studies gathering RWE on the geroprotective effects of repurposed drugs to support utilization within healthy longevity medicine. Finally, we summarize key metrics to consider when implementing QoL assays in studies, and present the short-form 36 (SF-36) as the most well-suited candidate endpoint.
Clinical Outcomes and Safety of Upper Endoscopy While on Glucagon-Like Peptide-1 Receptor Agonists
Authors: Stephen A Firkins, Joy Yates, Neehal Shukla, Rajat Garg, John J Vargo, Anthony Lembo
Journal: Clinical Gastroenterology and Hepatology (2024)

Glucose-like peptide-1-receptor agonists (GLP-1RAs) have become integral to the management of type 2 diabetes and obesity. GLP-1RAs work in part through delaying gastric emptying, raising concerns about retained gastric contents (RGC) during esophagogastroduodenoscopy (EGD).
Comparative long-term efficacy of phenol-croton oil chemical peels for persistent melasma at varied Croton tiglium oil concentrations
Authors: Mayra B.C. Maymone, Fatima N. Mirza, Denise Steiner, Felipe Ribeiro, Marina Landau, Carolina Marçon, Tereza C. Celidonio, Seaver L. Soon, Carlos G. Wambier
Journal: Journal of the American Academy of Dermatology (2024)