ACUTE HEMOLYTIC ANEMIA CAUSED BY SULFATHIAZOLE
Authors: Joseph J. Bunim, Murray Israel
Journal: Annals of Internal Medicine (1942)

Case Reports1 February 1942ACUTE HEMOLYTIC ANEMIA CAUSED BY SULFATHIAZOLEJOSEPH J. BUNIM, M.D., MURRAY ISRAEL, M.D.JOSEPH J. BUNIM, M.D.Search for more papers by this author, MURRAY ISRAEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-2-333 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe first case of hemolytic anemia resulting from sulfanilamide was reported by Harvey and Janeway1two and a half years after Domagk had introduced this drug into clinical medicine in 1935. Since then a number of similar reports have appeared, and W. B. Wood2found the incidence of this toxic reaction to be as high as 4.0 per cent in his series of 522 cases at the Johns Hopkins Hospital. Two fatal cases3, 4have already been described. The sulfapyridine derivative, introduced by Whitby in 1938 primarily as an effective chemotherapeutic agent against the pneumococcus, offered, in addition, the not...Bibliography1. HARVEYJANEWAY AMCA: Development of acute hemolytic anemia, Jr. Am. Med. Assoc., 1937, cix, 12. CrossrefGoogle Scholar2. WOOD WB: Anemia during sulfanilamide therapy, Jr. Am. Med. Assoc., 1938, cxi, 1916. CrossrefGoogle Scholar3. KOLETSKY S: Fatal hemolytic anemia following the administration of sulfanilamide, Jr. Am. Med. Assoc., 1939, cxiii, 291. CrossrefGoogle Scholar4. WOOD H: A fatality from acute hemolytic anemia which developed during the administration of sulfanilamide, South. Med. Jr., 1938, xxxi, 646. CrossrefGoogle Scholar5. RAVIDCHESNER JMH: Fatal case of hemolytic anemia and nephritic uremia following sulfapyridine administration, Am. Jr. Med. Sci., 1940, cxcix, 380. CrossrefGoogle Scholar6. FOSBINDERWALTER RJLA: Sulfanilamide derivatives of heterocyclic amines, Jr. Am. Chem. Soc., 1939, lxi, 2032. CrossrefGoogle Scholar7. LOTTBERGEIM WAFH: 2-(-aminobenzenesulfonamide)-thiazole: a new chemotherapeutic agent, Jr. Am. Chem. Soc., 1939, lxi, 3593. CrossrefGoogle Scholar8. LONG PH: Sulfathiazole and sulfamethylthiazole, Jr. Am. Med. Assoc., 1940, cxiv, 870. Google Scholar9. SPINKHANSEN WWAE: Sulfathiazole—clinical evaluation, Jr. Am. Med. Assoc., 1940, cxv, 840. CrossrefGoogle Scholar10. VAN DYKEGREEPRAKEMCKEE HBROGCM: Observations on the toxicology of sulfathiazole and sulfapyridine, Proc. Soc. Exper. Biol. and Med., 1939, xlii, 410. CrossrefGoogle Scholar11. LONGHAVILANDEDWARDS PHJWLB: Acute toxicity, absorption and excretion of sulfathiazole and certain of its derivatives, Proc. Soc. Exper. Biol. and Med., 1940, xliii, 328. CrossrefGoogle Scholar12. FLIPPINSCHWARTZROSE HFLSB: Comparative effectiveness and toxicity of sulfathiazole and sulfapyridine in pneumococcic pneumonia, ANN. INT. MED., 1940, xiii, 2038. Google Scholar13. OTTENBERGFOX RCL: Explanation for the cyanosis of sulfanilamide therapy, Proc. Soc. Exper. Biol. and Med., 1938, xxxviii, 479. CrossrefGoogle Scholar14. FOXHOGGOTTENBERG CLBR: The occurrence of methemoglobinemia during therapy with sulfapyridine, sulfathiazole and sulfamethylthiazole, Jr. Clin. Invest., 1940, xix, 792. Google Scholar15. DE GOWINWARNERRANDALL ELEDWL: Renal insufficiency from blood transfusion, Arch. Int. Med., 1938, lxi, 609. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Williston Park, L. I., N. Y.*Received for publication October 25, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFestigkeitsprüfung bei ruhender BeanspruchungFestigkeitsprüfung bei ruhender BeanspruchungThe influence of phenolphthalein ingestion on red blood cell resistance to hemolysisHÆMOLYTIC ANÆMIA DUE TO SULPHAPYRIDINE 1 February 1942Volume 16, Issue 2Page: 333-339KeywordsChemotherapeutic agentsDrugsHemolytic anemiaPneumococcus ePublished: 1 December 2008 Issue Published: 1 February 1942 PDF downloadLoading ...