tbuckley/cabot-search huggingface dataset:
Agreement of Different Drug-Drug Interaction Checkers for Proton Pump Inhibitors
Authors: Massimo Carollo, Salvatore Crisafulli, Margherita Selleri, Luca Piccoli, Luca L’Abbate, Gianluca Trifirò
Journal: JAMA Network Open (2024)

Importance Proton pump inhibitors (PPIs) are a widely prescribed class of drugs, potentially interacting with a large number of medicines, especially among older patients with multimorbidity and polypharmacy. Beyond summary of product characteristics (SPCs), interaction checkers (ICs) are routinely used tools to help clinicians in medication review interventions. Objective To assess the consistency of information on drugs potentially interacting with PPIs as reported in their SPCs and different ICs. Design, Setting, and Participants This cross-sectional study was conducted using data from SPCs for 5 PPIs (omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole) and 5 ICs (ie, INTERCheck WEB, Micromedex, Lexicomp, Epocrates, and drugs.com). Information from the SPCs and the ICs were extracted between July 15 and 30, 2023. Main Outcomes and Measures The main outcome was the level of agreement among SPCs and the 5 ICs in identifying drugs potentially interacting with PPIs and attributing drug-drug interaction (DDI) severity categories. The level of agreement was computed using Gwet AC1 statistic on the 5 ICs and by comparing 4-sets and 2-sets of ICs. As a sensitivity analysis, the level of agreement in listing PPI-related DDIs was evaluated using Cohen κ and Fleiss κ coefficients. Results Considering SPCs and the 5 ICs, a total of 518 potentially interacting drugs with omeprazole were reported, 455 for esomeprazole, 433 for lansoprazole, 421 for pantoprazole, and 405 for rabeprazole. As compared with the ICs, the SPCs reported a much smaller number of drugs potentially interacting with PPIs, with proportions ranging from 2.7% (11 potentially interacting drugs) for rabeprazole to 7.6% (33 potentially interacting drugs) for lansoprazole of the total identified drugs at risk of interaction with a PPI. The overall level of agreement among the 5 ICs for identifying potential interactions was poor (from 0.23 [95% CI, 0.21-0.25] for omeprazole to 0.27 [95% CI, 0.24-0.29] for pantoprazole and 0.27 [95% CI, 0.25-0.29] for rabeprazole). Similarly, the level of agreement was low in 4-set and 2-set analyses as well as when restricting the analysis to the potential DDIs identified as severe (range, 0.30-0.32). Conclusions and Relevance This cross-sectional study found significant disagreement among different ICs and SPCs, highlighting the need to focus on standardizing DDI databases. Therefore, to ensure evaluation and prevention of clinically relevant DDIs, it is recommended to revise multiple ICs and consult with specialists, such as clinical pharmacologists, particularly for patients with complex medical conditions.
Prenatal Exposure to Ambient Air Pollution and Cerebral Palsy
Authors: Yu Zhang, Yuhong Hu, Robert Talarico, Xinye Qiu, Joel Schwartz, Deshayne B. Fell, Maryam Oskoui, Eric Lavigne, Carmen Messerlian
Journal: JAMA Network Open (2024)

Importance Air pollution is associated with structural brain changes, disruption of neurogenesis, and neurodevelopmental disorders. The association between prenatal exposure to ambient air pollution and risk of cerebral palsy (CP), which is the most common motor disability in childhood, has not been thoroughly investigated. Objective To evaluate the associations between prenatal residential exposure to ambient air pollution and risk of CP among children born at term gestation in a population cohort in Ontario, Canada. Design, Setting, and Participants Population-based cohort study in Ontario, Canada using linked, province-wide health administrative databases. Participants were singleton full term births (≥37 gestational weeks) born in Ontario hospitals between April 1, 2002, and March 31, 2017. Data were analyzed from January to December 2022. Exposures Weekly average concentrations of ambient fine particulate matter with a diameter 2.5 μm (PM 2.5 ) or smaller, nitrogen dioxide (NO 2 ), and ozone (O 3 ) during pregnancy assigned by maternal residence reported at delivery from satellite-based estimates and ground-level monitoring data. Main outcome and measures CP cases were ascertained by a single inpatient hospitalization diagnosis or at least 2 outpatient diagnoses for children from birth to age 18 years. Results The present study included 1 587 935 mother-child pairs who reached term gestation, among whom 3170 (0.2%) children were diagnosed with CP. The study population had a mean (SD) maternal age of 30.1 (5.6) years and 811 745 infants (51.1%) were male. A per IQR increase (2.7 μg/m 3 ) in prenatal ambient PM 2.5 concentration was associated with a cumulative hazard ratio (CHR) of 1.12 (95% CI, 1.03-1.21) for CP. The CHR in male infants (1.14; 95% CI, 1.02-1.26) was higher compared with the CHR in female infants (1.08; 95% CI, 0.96-1.22). No specific window of susceptibility was found for prenatal PM 2.5 exposure and CP in the study population. No associations or windows of susceptibility were found for prenatal NO 2 or O 3 exposure and CP risk. Conclusions and relevance In this large cohort study of singleton full term births in Canada, prenatal ambient PM 2.5 exposure was associated with an increased risk of CP in offspring. Further studies are needed to explore this association and its potential biological pathways, which could advance the identification of environmental risk factors of CP in early life.
Home and school pollutant exposure, respiratory outcomes, and influence of historical redlining
Authors: Kyung Hwa Jung, Kira L Argenio, Daniel J Jackson, Rachel L Miller, Matthew S Perzanowski, Andrew G Rundle, Leonard B Bacharier, William W Busse, Robyn T Cohen, Cynthia M Visness, Michelle A Gill, Rebecca S Gruchalla, Gurjit K Hershey, Rachel K Kado, Michael G Sherenian, Andrew H Liu, Melanie M Makhija, Dinesh K Pillai, Katherine Rivera-Spoljaric, Peter J Gergen, Matthew C Altman, Megan T Sandel, Christine A Sorkness, Meyer Kattan, Stephanie Lovinsky-Desir
Journal: Journal of Allergy and Clinical Immunology (2024)
Time from admission to randomization and the effect of empagliflozin in acute heart failure: A post‐hoc analysis from <scp>EMPULSE</scp>
Authors: João Pedro Ferreira, Jonathan P. Blatchford, John R Teerlink, Mikhail Kosiborod, Christiane E Angermann, Jan Biegus, Sean P Collins, Jasper Tromp, Michael E Nassif, Mitchell A Psotka, Josep Comin-Colet, Robert J. Mentz, Martina Brueckmann, Matias Nordaby, Piotr Ponikowski, Adriaan A. Voors
Journal: European Journal of Heart Failure (2024)
Author Correction: Self-administered mindfulness interventions reduce stress in a large, randomized controlled multi-site study
Authors: Alessandro Sparacio, Hans IJzerman, Ivan Ropovik, Filippo Giorgini, Christoph Spiessens, Bert N. Uchino, Joshua Landvatter, Tracey Tacana, Sandra J. Diller, Jaye L. Derrick, Joahana Segundo, Jace D. Pierce, Robert M. Ross, Zoë Francis, Amanda LaBoucane, Christine Ma-Kellams, Maire B. Ford, Kathleen Schmidt, Celia C. Wong, Wendy C. Higgins, Bryant M. Stone, Samantha K. Stanley, Gianni Ribeiro, Paul T. Fuglestad, Valerie Jaklin, Andrea Kübler, Philipp Ziebell, Crystal L. Jewell, Yulia Kovas, Mahnoosh Allahghadri, Charlotte Fransham, Michael F. Baranski, Hannah Burgess, Annika B. E. Benz, Maysa DeSousa, Catherine E. Nylin, Janae C. Brooks, Caitlyn M. Goldsmith, Jessica M. Benson, Siobhán M. Griffin, Stephen Dunne, William E. Davis, Tam J. Watermeyer, William B. Meese, Jennifer L. Howell, Laurel Standiford Reyes, Megan G. Strickland, Sally S. Dickerson, Samantha Pescatore, Shayna Skakoon-Sparling, Zachary I. Wunder, Martin V. Day, Shawna Brenton, Audrey H. Linden, Christopher E. Hawk, Léan V. O’Brien, Tenzin Urgyen, Jennifer S. McDonald, Kim Lien van der Schans, Heidi Blocker, Caroline Ng Tseung-Wong, Gabriela M. Jiga-Boy
Journal: Nature Human Behaviour (2024)
Predeductible Coverage and Receipt of Telemental Health Visits
Authors: Kacey Fang, Jaclyn Marshall, A. Mark Fendrick, Haiden A. Huskamp, Latoya Thomas, Ateev Mehrotra
Journal: JAMA Network Open (2024)

This cohort study examines the utilization changes associated with the reintroduction of cost sharing for patients receiving telemental health services.
Wheeze Among Children Born During COVID-19 Lockdown
Authors: Elisa Barbieri, Anna Cantarutti, Riccardo Boracchini, Luca Bonadies, Daniele Donà, Carlo Giaquinto, Eugenio Baraldi
Journal: JAMA Network Open (2024)

This cohort study evaluates the association between the 2020 COVID-19 lockdown and rates of wheezing and use of respiratory medications among children in Italy.
Navigating Drug Interactions with Proton Pump Inhibitors
Authors: Carolyn M. Tan, David N. Juurlink
Journal: JAMA Network Open (2024)

Massimo Carollo, MD; Salvatore Crisafulli, MSc; Margherita Selleri, MSc; Luca Piccoli, MSc; Luca L'Abbate, MSc; Gianluca Trifirò, PhD
Genomic profiling of a multi-lineage and multi-passage patient-derived xenograft biobank reflects heterogeneity of ovarian cancer
Authors: Tianyu Qin, Zhe Hu, Li Zhang, Funian Lu, Rourou Xiao, Yiting Liu, Junpeng Fan, Ensong Guo, Bin Yang, Yu Fu, Xucui Zhuang, Xiaoyan Kang, Zimeng Wu, Zixuan Fang, Yaoyuan Cui, Xingyuan Hu, Jingjing Yin, Miao Yan, Fuxia Li, Kun Song, Gang Chen, Chaoyang Sun
Journal: Cell Reports Medicine (2024)

Ovarian cancer (OC) manifests as a complex disease characterized by inter- and intra-patient heterogeneity. Despite enhanced biological and genetic insights, OC remains a recalcitrant malignancy with minimal survival improvement. Based on multi-site sampling and a multi-lineage patient-derived xenograft (PDX) establishment strategy, we present herein the establishment of a comprehensive PDX biobank from histologically and molecularly heterogeneous OC patients. Comprehensive profiling of matched PDX and patient samples demonstrates that PDXs closely recapitulate parental tumors. By leveraging multi-lineage models, we reveal that the previously reported genomic disparities of PDX could be mainly attributed to intra-patient spatial heterogeneity instead of substantial model-independent genomic evolution. Moreover, DNA damage response pathway inhibitor (DDRi) screening uncovers heterogeneous responses across models. Prolonged iterative drug exposure recapitulates acquired drug resistance in initially sensitive models. Meanwhile, interrogation of induced drug-resistant (IDR) models reveals that suppressed interferon (IFN) response and activated Wnt/β-catenin signaling contribute to acquired DDRi drug resistance.
Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers
Authors: Lihuan Shang, Xue Jiang, Xinbao Zhao, Xi Huang, Xiaojuan Wang, Xue Jiang, Xiangzhan Kong, Mingkang Yao, Shanping Jiang, Ping-Pui Wong
Journal: Cell Reports Medicine (2024)

Low migratory dendritic cell (DC) levels pose a challenge in cancer immune surveillance, yet their impact on tumor immune status and immunotherapy responses remains unclear. We present clinical evidence linking reduced migratory DC levels to immune-cold tumor status, resulting in poor patient outcomes. To address this, we develop an autologous DC-based nanovaccination strategy using patient-derived organoid or cancer cell lysate-pulsed cationic nanoparticles (cNPs) to load immunogenic DC-derived microvesicles (cNPcancer cell@MVDC). This approach transforms immune-cold tumors, increases migratory DCs, activates T cells and natural killer cells, reduces tumor growth, and enhances survival in orthotopic pancreatic and lung cancer models, surpassing conventional methods. In vivo imaging reveals superior cNPcancer cell@MVDC accumulation in tumors and lymph nodes, promoting immune cell infiltration. Mechanistically, cNPs enrich mitochondrial DNA, enhancing cGAS-STING-mediated DC activation and migration. Our strategy shifts cold tumors to a hot state, enhancing antitumor immunity for potential personalized cancer treatments.
Chimeric antigen receptor-induced antigen loss protects CD5.CART cells from fratricide without compromising on-target cytotoxicity
Authors: Royce Ma, Mae Woods, Phillip Burkhardt, Noah Crooks, Dayenne G. van Leeuwen, Daniil Shmidt, Jacob Couturier, Alexandre Chaumette, Divya Popat, LaQuisa C. Hill, Rayne H. Rouce, Sachin Thakkar, Aaron F. Orozco, Alexandre F. Carisey, Malcolm K. Brenner, Maksim Mamonkin
Journal: Cell Reports Medicine (2024)

Chimeric antigen receptor T cells (CART) targeting lymphocyte antigens can induce T cell fratricide and require additional engineering to mitigate self-damage. We demonstrate that the expression of a chimeric antigen receptor (CAR) targeting CD5, a prominent pan-T cell antigen, induces rapid internalization and complete loss of the CD5 protein on T cells, protecting them from self-targeting. Notably, exposure of healthy and malignant T cells to CD5.CART cells induces similar internalization of CD5 on target cells, transiently shielding them from cytotoxicity. However, this protection is short-lived, as sustained activity of CD5.CART cells in patients with T cell malignancies results in full ablation of CD5+ T cells while sparing healthy T cells naturally lacking CD5. These results indicate that continuous downmodulation of the target antigen in CD5.CART cells produces effective fratricide resistance without undermining their on-target cytotoxicity.
Medicaid-Covered Peer Support Services Used by Enrollees With Opioid Use Disorder
Authors: Yuhua Bao, Hao Zhang, Kayla Hutchings, Rebecca Arden Harris, Tara Calderbank, Bruce R. Schackman
Journal: JAMA Network Open (2024)

This cross-sectional study provides a multistate description of utilization of Medicaid-covered peer support services in 2019 by enrollees with opioid use disorder (OUD).
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
Authors: Lynn Bonetti, Veronika Horkova, Melanie Grusdat, Joseph Longworth, Luana Guerra, Henry Kurniawan, Davide G. Franchina, Leticia Soriano-Baguet, Carole Binsfeld, Charlène Verschueren, Sabine Spath, Anouk Ewen, Eric Koncina, Jean-Jacques Gérardy, Takumi Kobayashi, Catherine Dostert, Sophie Farinelle, Janika Härm, Yu-Tong Fan, Ying Chen, Isaac S. Harris, Philipp A. Lang, Vasilis Vasiliou, Ari Waisman, Elisabeth Letellier, Burkhard Becher, Michel Mittelbronn, Dirk Brenner
Journal: Cell Metabolism (2024)

saves mutant mice from infection-induced lethality
Author Correction: Comparing experience- and description-based economic preferences across 11 countries
Authors: Hernán Anlló, Sophie Bavard, FatimaEzzahra Benmarrakchi, Darla Bonagura, Fabien Cerrotti, Mirona Cicue, Maelle Gueguen, Eugenio José Guzmán, Dzerassa Kadieva, Maiko Kobayashi, Gafari Lukumon, Marco Sartorio, Jiong Yang, Oksana Zinchenko, Bahador Bahrami, Jaime Silva Concha, Uri Hertz, Anna B. Konova, Jian Li, Cathal O’Madagain, Joaquin Navajas, Gabriel Reyes, Atiye Sarabi-Jamab, Anna Shestakova, Bhasi Sukumaran, Katsumi Watanabe, Stefano Palminteri
Journal: Nature Human Behaviour (2024)
Reporting of surrogate endpoints in randomised controlled trial protocols (SPIRIT-Surrogate): extension checklist with explanation and elaboration
Authors: Anthony Muchai Manyara, Philippa Davies, Derek Stewart, Christopher J Weir, Amber E Young, Jane Blazeby, Nancy J Butcher, Sylwia Bujkiewicz, An-Wen Chan, Dalia Dawoud, Martin Offringa, Mario Ouwens, Asbjørn Hróbjartsson, Alain Amstutz, Luca Bertolaccini, Vito Domenico Bruno, Declan Devane, Christina D C M Faria, Peter B Gilbert, Ray Harris, Marissa Lassere, Lucio Marinelli, Sarah Markham, John H Powers, Yousef Rezaei, Laura Richert, Falk Schwendicke, Larisa G Tereshchenko, Achilles Thoma, Alparslan Turan, Andrew Worrall, Robin Christensen, Gary S Collins, Joseph S Ross, Rod S Taylor, Oriana Ciani
Journal: BMJ (2024)
Author Correction: Enhanced cholera surveillance to improve vaccination campaign efficiency
Authors: Hanmeng Xu, Kaiyue Zou, Juan Dent, Kirsten E. Wiens, Espoir Bwenge Malembaka, Godfrey Bwire, Placide Welo Okitayemba, Lee M. Hampton, Andrew S. Azman, Elizabeth C. Lee
Journal: Nature Medicine (2024)
Author Correction: Clinical surveillance systems obscure the true cholera infection burden in an endemic region
Authors: Sonia T. Hegde, Ashraful Islam Khan, Javier Perez-Saez, Ishtiakul Islam Khan, Juan Dent Hulse, Md Taufiqul Islam, Zahid Hasan Khan, Shakeel Ahmed, Taner Bertuna, Mamunur Rashid, Rumana Rashid, Md Zakir Hossain, Tahmina Shirin, Kirsten E. Wiens, Emily S. Gurley, Taufiqur Rahman Bhuiyan, Firdausi Qadri, Andrew S. Azman
Journal: Nature Medicine (2024)
Timing of Coronary Angiography for Patients Without St-Segment Elevation After Cardiac Arrest: A Systematic Review and Meta-Analysis
Authors: Mohammed Al-Sadawi
Journal: Clinical Cardiology and Cardiovascular Interventions (2023)

Background/Aim: Although early coronary angiography (CAG) is currently recommended in patients with out of hospital cardiac arrest (OHCA) with ST segment elevation on electrocardiogram (EKG), the benefits in OHCA patients without ST segment elevation is unclear. The purpose of this meta-analysis is to evaluate the association between timing of CAG and clinical outcomes in patients with OHCA without ST segment elevation on EKG. Methods: We performed a literature search for studies reporting an association between timing of CAG and study endpoints. The primary endpoint was all-cause mortality. The secondary endpoints neurological outcome and need for dialysis. The search included the following databases: Ovid MEDLINE, EMBASE, Web of Science, and Google Scholar. The search was not restricted to time or publication status. Results: A total of 17 studies with 8118 participants (3447 with early CAG vs 4671 with late/no CAG) were included. The mean duration of follow-up was 138 days. Early CAG showed a trend toward reduction in all-cause mortality but this was not statistically significant (OR 0.83, 95% CI 0.60-1.14; p=0.25). Early CAG showed a trend toward favorable neurological outcome but this was not statistically significant (OR 0.75, 95% CI 0.48-1.18; p=0.21. Early CAG was not associated with increased risk for acute renal failure requiring hemodialysis (HD) (OR 1.0, 95% CI 0.73-1.38; p=0.99). Subgroup analysis by time to CAG demonstrated that early CAG was associated with increased all-cause mortality if performed immediately (OR 1.3, 95% CI 1.02-1.66; p=0.03), but decreased all-cause mortality if performed within 6 hours or within 24 hours (OR 0.73, 95% CI 0.58-0.90; p&lt;0.01; OR 0.34, 95% CI 0.14-0.79; p=0.01). Conclusions: Early CAG in patients presenting after OHCA without ST segment elevation may be beneficial compared to late/no CAG if performed after initial patient stabilization.
Clinical Response to PAH Treatment Does Not Depend on Pulmonary Artery Wedge Pressure – A Meta-Analysis Using Individual Participant Data from Randomized Clinical Trials
Authors: Gabor Kovacs, Jude Moutchia, Katarina Zeder, Bradley A. Maron, Nadine Al-Naamani, Corey Ventetuolo, Horst Olschewski, Steven M. Kawut
Journal: American Journal of Respiratory and Critical Care Medicine (2024)
Generation and repair of thymic epithelial cells
Authors: Graham Anderson, Emilie J. Cosway, Kieran D. James, Izumi Ohigashi, Yousuke Takahama
Journal: The Journal of Experimental Medicine (2024)

In the vertebrate immune system, thymus stromal microenvironments support the generation of αβT cells from immature thymocytes. Thymic epithelial cells are of particular importance, and the generation of cortical and medullary epithelial lineages from progenitor stages controls the initiation and maintenance of thymus function. Here, we discuss the developmental pathways that regulate thymic epithelial cell diversity during both the embryonic and postnatal periods. We also examine how thymus microenvironments respond to injury, with particular focus on mechanisms that ensure regeneration of thymic epithelial cells for the restoration of thymus function.
Polymorphism-Aware Models in RevBayes: Species Trees, Disentangling Balancing Selection, and GC-Biased Gene Conversion
Authors: Svitlana Braichenko, Rui Borges, Carolin Kosiol
Journal: Molecular Biology and Evolution (2024)

Abstract The role of balancing selection is a long-standing evolutionary puzzle. Balancing selection is a crucial evolutionary process that maintains genetic variation (polymorphism) over extended periods of time; however, detecting it poses a significant challenge. Building upon the Polymorphism-aware phylogenetic Models (PoMos) framework rooted in the Moran model, we introduce a PoMoBalance model. This novel approach is designed to disentangle the interplay of mutation, genetic drift, and directional selection (GC-biased gene conversion), along with the previously unexplored balancing selection pressures on ultra-long timescales comparable with species divergence times by analyzing multi-individual genomic and phylogenetic divergence data. Implemented in the open-source RevBayes Bayesian framework, PoMoBalance offers a versatile tool for inferring phylogenetic trees as well as quantifying various selective pressures. The novel aspect of our approach in studying balancing selection lies in polymorphism-aware phylogenetic models’ ability to account for ancestral polymorphisms and incorporate parameters that measure frequency-dependent selection, allowing us to determine the strength of the effect and exact frequencies under selection. We implemented validation tests and assessed the model on the data simulated with SLiM and a custom Moran model simulator. Real sequence analysis of Drosophila populations reveals insights into the evolutionary dynamics of regions subject to frequency-dependent balancing selection, particularly in the context of sex-limited color dimorphism in Drosophila erecta.
Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development
Authors: Isabel Baldwin, Ellen A. Robey
Journal: The Journal of Experimental Medicine (2024)

During thymic development, thymocytes adjust their TCR response based on the strength of their reactivity to self-peptide MHC complexes. This tuning process allows thymocytes with a range of self-reactivities to survive positive selection and contribute to a diverse T cell pool. In this review, we will discuss recent advances in our understanding of how thymocytes tune their responsiveness during positive selection, and we present a “sequential selection” model to explain how MHC specificity influences lineage choice. We also discuss recent evidence for cell type diversity in the medulla and discuss how this heterogeneity may contribute to medullary niches for negative selection and regulatory T cell development.
Author Correction: LINE-1 transcription activates long-range gene expression
Authors: Xiufeng Li, Luyao Bie, Yang Wang, Yaqiang Hong, Ziqiang Zhou, Yiming Fan, Xiaohan Yan, Yibing Tao, Chunyi Huang, Yongyan Zhang, Xueyan Sun, John Xiao He Li, Jing Zhang, Zai Chang, Qiaoran Xi, Anming Meng, Xiaohua Shen, Wei Xie, Nian Liu
Journal: Nature Genetics (2024)
Author Correction: Lisocabtagene maraleucel in follicular lymphoma: the phase 2 TRANSCEND FL study
Authors: Franck Morschhauser, Saurabh Dahiya, M. Lia Palomba, Alejandro Martin Garcia-Sancho, Juan Luis Reguera Ortega, John Kuruvilla, Ulrich Jäger, Guillaume Cartron, Koji Izutsu, Martin Dreyling, Brad Kahl, Hervé Ghesquieres, Kirit Ardeshna, Hideki Goto, Anna Maria Barbui, Jeremy S. Abramson, Peter Borchmann, Isabelle Fleury, Stephan Mielke, Alan Skarbnik, Sven de Vos, Manali Kamdar, Reem Karmali, Andreas Viardot, Thalia Farazi, Omotayo Fasan, James Lymp, Min Vedal, Rina Nishii, Ariel Avilion, Jessica Papuga, Jinender Kumar, Loretta J. Nastoupil
Journal: Nature Medicine (2024)