RNA Interference With Zilebesiran for Mild to Moderate Hypertension
Authors: George L. Bakris, Manish Saxena, Anil Gupta, Fadi Chalhoub, Jongtae Lee, Daniel Stiglitz, Nune Makarova, Nitender Goyal, Weinong Guo, Dion Zappe, Akshay S. Desai, George Carr, Christopher Case, Lauren Jaeger, Lisa Bruns, Ginger Stratman, Christy Kidwell, Suzin Cunningham, Nicholas Piccone, Mordecai Klein, Maria Acuna, Srishti Arora, Amanda Clark, Ezekiel Fink, Cesia Garcia, Astrid George, Elizabeth Gray, Caroline Mahaffey, Maria McElheney, Elizabeth Ortiz, Sunny Saumya, Adele Wallace, Jenelle Watts, Daisy Zambrana, Douglas Denham, Erica Rivera, Ayoade Avworo, Parke Hedges, Corri Fancher, Rafik Abadier, Lisa Braud, Laura Cenatiempo, Amanda Elwood, Linda Gray, Peter Gray, Kimberly Griffin, Hasibul Khan, Nadeen Kongquee, Susan LaTorraca, Tiffany Liles, Jill Livingston, Marc Lozano, Amy Lupton, Tiffany Lyles, Deana Mardini, Susan Moss, Karen Packer, Aakash Patel, Tina Russ, Brianna Scinicariello, Shannon Trull, Blair Warren, Fadi Chalhoub, Susan Angel, Sujeeta Dhakhwa, Ivy Gabon, Leticia Goodwin, Nandita Joshi Jones, Mark Joyce, Niketa Kamble, Brooke McFall, Rose Githiiyu, Leticia Robinson, Lauren Tomlinson, Emir Hadziavdic, Stephany Vega, James Greenwald, Jessica Achan, Lucille Ruiz, Mehwish Buksh, Omkar Chauhan, Elisee Derisseau, Faith Ferguson, Monika Grabowski, Larisa Gumerova, Miriam Hernandez, Kenna Martin, Krina Patel, Dibnain Nanda, Jose Perez, Corey Ribeca, Elijah Rueda, Ana Sordi Guth, Nader Zaki, Ebony Green, Nina Mondoc, Robert Buynak, Stephanie Andree, Martha Brazinsky, Lisa Fuller, Nikki Green, Hannade Ibrahim, Marilyn Idowu, Miranda Lee, Erica Lewis, Goldie Luna, Rachel McNeal, Alicia Owens, Consuelita Perez, Taryn Petty, Megan Smith, Patricia Volom, Angela Webb, Destiny Williams, Mark Yarosz, Nashwa Gabra, Nabil Andrawis, Amy Aziz, Magda Hanna, Josefina Manalo, Victoria Helow, William Davila, Sydney Crisp, Yvonne Douglas, Jenna Everett, Sarah Graham, Ellen Heard, Michelle Mackie, Suman Mayer, Lisa Moore, Stephanie Resurreccion, Jennifer Sidey, Michael Stephens, Mary Strickland, Dawn Van Camp, Stephanie Wilder, Anne Witt, Jolenne Wolfer, Lucas Groben, Lindsey Aeschliman, Emily Audlehelm, Casey Fitz, Judi Greene, Emily Hippen, Michelle Johnson, Allan Latcham, Shekela Leggett, Keeta Link, James Lovell, Kourtney Marlow, Cynthia Marske, Kelsey Maxwell, Charlotte Newsom-Henderson, Darcie Oelberg, Kathleen Ollinger, Rebecca Risius, Kylea Ryther, Alyssa Waddell, Tyler Zellerman, Martin Albornoz Santofimio, Stephen Plantholt, Morgan Beatty, Heather Blubaugh, Tina Bootz, Jeffrey Cole, Jasmine Conners, Vicki Coombs, Chloe Goddard, Carlos Ince, Gail Kiddy, Barbara Klimuszka, Frederick Kuhn, David Lowry, Patricia Previll, Stephanie Rioux, Jasmine Scott, Britney Shepherd, Amy Urffer, Sarah Smiley, Gregg Lucksinger, Allison Alvord, Jordan Anderson, Courtney Block, Ashley Chan, John Delgado, Kambrea Frost, Levi Gadbois, Danuel Hamlin, Sarah Johnson, Vivianna Juncal, Kary Kelly, Emily Kelly, Lilly Kelly, Avery Kerwin, Audrey Kuehl, Jaleh Ostovar, Ryan Rackley, George Rocha, Lacee Sandberg, Sarah Sheghewi, Tiffany Smith, Ben Taucher, Cecilia Vasquez, Francisca Villa Rodriguez, Jay Weisbart, Veronica Wescom, Keenan Williams, Jeffrey Scott Overcash, Angela Anorve, Hunter Asmann, Gordon Bovee, Laura Castillo, Hanh Chu, Jordan Coslet, Allison Davis, Mary Dinan, Amanda Dubbula, Jacob Esparza, Ann Foster, Andrea Garcia, Jessica Gonzales, Lizette Gonzalez, Pat Kappen, Allison Kornblatt, Brandon Lauderdale, Kia Lee, Sylvia Lindholm, Ashliegh Lindsay, Luis Llanos Gomez, Adrienna Marquez, Catherine Meza, Shandel Odom, Makenna Orel, Shanna Paselio, Samuel Penziner, Helen Pu, Kimberly Quillin, Cesar Ramirez, Roxanna Ramirez, Monica Salgado, Marcy Shores, Raquel Taitingfong, Jennifer Tande, Van Tuiletufuga, Katrina Tyler, Linda Vega, Karla Zepeda, Corey Anderson, Nikki Carhill, Benjamin Clark, Lisa Dean, Naomi Devine, Sophia DiPeri, Gladys Espinal, Ronald Hawkins, Gabriela Irra, Angela Ledezma, Georgina Lopez-Wood, Micaela Luna, Wael Mansour, Tasha Marriott, Ashley Perez, James Ramsey, William Reedy, Hannah Spinks, Cecilia Tanori, David Tatelbaum, Rudy Vasquez, Kim Vasquez, Jori Vigil, Isabel Worthen, Devin Yu, Jessica Zuniga, Patrick Dennis, Lauren Alvarado, Armand Cox, Victoria Cullaro, John Dunbar, Katherine Giorlando, London Hannan, Tyler Hastings, Geoff Hoskins, Emily Krambeck, Juliana Laurent, Olga Michelle Martinez, Reggie Mister, Autumn Moss, Margaret Muli, Nicolette Quinn, Brittany Reed, Adam Robinson, Casey Saavedra, Caitlin Simon, Derek Smith, Dylan Touchet, Annie Wright, Miguel Trevino, Benjamin DeVries, Sara Allison-Hicks, Timothy Light, Wendy Rubach, Kimberly Mai, Tracey Osborn, Lori Sheets, Dusty Carver, Alan Reichman, Djamchid Lotfi, Nelson Berrios, Sangeetha Vulichi, Tulashi Naguleswaran, Yvonne Subhan, Monica Rios, Diana Baron, Abdul Khowaja, Siddharth Nair, Michael Vicente, Luvia Lizette Gonzalez Gomez, Uriel Salvador Acevedo Gomez, Janak Lamichhane, Efe Ekomoda, Akhila Nair, Shana Maldonado, Mobina Naqvi, Fahim Dayani, Sontoshi Patro, LubnaGazal Golandaz, Amin Jaka, Santiago Rios, Maushami Gurung, Pratik Gongloor, David Coreas, Tarik Demir, Zehra Celik, Lora McGill, Lisa Usdan, Valerie Arnold, Keerthi Heckle, Carolyn Scatamacchia, Codi Anthony, Carol Marsh, Jernell Fair, Anekeya Stewart, Rebecca Hamlet, Robyn Presley, Charles Granberry, Melissa Flowers, Cathy Houpt, Debra O'Brien, Kelsey Evans, Mary Williams, Julia Sinatra, Irene Powell, Tavia Flagg, LaKeshia Pipkin, Vanessa Wheeler, Erin Wells, Brandi Gruber, Amber Jones, Monica Toor, Kelly Iskiwitz, Mia Boyd, Sharneiseca Epps, Frank Cole, Charlotte Grayson-Mathis, Maci Web, Catrina Turner, Krystal Reese, Dana Robinson, Atira Goodwin, Kyle Parker, Chantelle Ward, Amber Solomon, Taylor Lawson, Marquita Pledger, Amanda Lane Peterson, Monique Carignan, David Oguoma-Richards, Stacy Jones, Kiara McFarland-Head, Brittany Bundeff, Stephanie Wojtowicz, Cynthia Holland, Taylor Sanders, Lee Simon, Caitlin Lawrence, Brittany Bolton, Kandice Lemoine, Kasey Harris, Hilary Kingsley, Danielle Bryant, Korie Clawson, Colleen Murphy, Dale Crawford Allison, Gregory Newman, Dedra Preece, Pamela Zook, Taylor Roznos, Sharla Russell, Richard Rodriguez, Angela Roy, Stacey Layle, Purvi Mehra, Samantha Bowen, Daniel Johnson, Natalie Guillen, Sofia Leone, Guinevere McCormick, Laurel Hermann, Lerner Sarno, Taher Abellatif, Monica Cleghorn, Aya Elansary, Athalyah Israel, Michelle Leeward, Claudia Parra, Sydney Harris, Prianka Patel, Megan Cawley, Myrna Castro, Tatyana Miroshnikova, Michael Dever, Jorge Venereo, Henry Paez, Andres Isla, Yailin Martin, Ana Fernandez, Isabel Hernandez, Andrew Isla Lavoy, Nancy Rios, Armando Hernandez, Michael Denenberg, Treacy McTier, Caroline Reynolds, Lacie Thomas, Connie Eubanks, Tori Oliver, Michael Jacobs, Vincent Mirkil, Kathleen Menasche, Michael Yee, Bonny Alvarado Vasquez, Candice Garcia, Laura Elio, Allan Arenas, Clarissa Buena, Cristina Garcia, Michael Cannon, Erin Novotny, Michelle Oliver, Amanda Cannon, Mark Gatdula, Cyn Gillenwater, Adam Rafi, Wissam Derian, Miranda Ramsey, Evan Culbreth, Catherine Fessler, Kelly Sorrill, Monica Mauri, Jeffrey 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Martin, Maria Acevedo, Amy Anderson, Talha Baig, Rana Baker, Reemsha Basrai, Nora Cabrera, Cassidy Caroll, Shanika Chatmon, Sukhvinder Cheema, Anum Chowdhry, Nicole Cordero, Carolina Deandres, Mounika Deshpande, Ambily Dileep, Kimberly Dolfi, Lara Eng, Niccirria Fountain, Ramani Gali, Adrienne Hernandez, Arsani Iskandar, Riaz Khan, Adrianna Knight, Soni Kundapati, Irma Lobo, Zahra Lokhandwala, Zara Lokhandwala, Faryal Mahmood, Rifa Marediya, Earl F Martin, Mirella Melendez, Asfand Moosa, Alefiyah Motiwala, Shamnun Muhebb, Monica Murray, Muneeb Rehman, Ariel Rivera, Ashay Shah, Sara Solorzano, Laila Somani, Loreta Soneira, Amy Starr, Danielle Thompson, Andrea Torres, Elizabeth Tran, Mohammad Ali Ullah, Allie Valentine, Laura Vaquerano, Amanda Yake, Yousra Yousif, Ashley Zaldivar, William Byars, Hillary Brown, Anne Claire Gaskin, Caitlynn Clayton, Christopher Davis, Sydney Dillon, Belinda Driggers, Anfernee Ferrell, Danielle Elizabeth Green, Lisa Hunt, Cathleen Jeffers, Cindy Kirkland, 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Audet-Verreault, Lyne Côté, Melissa Gagnon, Véronique Côté, Denise Morin, Jessica Fortin-Mimeault, Marc-Olivier Brassard, Helene Gagne, Sophie Rousseau, Ying Tung Sia, Ezequiel Guzzetti, Ramon Alejandro Gisbert, Mariana Dias, Mariana de Oliveira, Claudia Cote, Izabel Rodrigues, Johanne Blanchard, Laurence Labbe, Sabrina Dumoulin Lemay, Kathleen Beauchemin, Roxanne Turcotte, Annabelle Beaudoin, Chansamone Saliphod, Chantal Lamontagne, Josiane Trudel, Carolyne Beaudoin, Josée Blanchard, Annie Larouche, Cecile Robinaud, Valérie Paré, Alexandre Bergeron, Maude Bilodeau, Ethel Bellavance, Eve Betit, Karine Fortier, Josee Racine, Dinah Perras, Elyse Boulanger, Christelle Beauchesne, Sarah Lehoux, Vickie Turgeon, Rachele Cote, Marie-Eve Tardif, Naresh Aggarwal, Puja Aggarwal, Bharti Patel, Gurdeep Dhaliwal, Preeti Aggarwal, Guy Tellier, Gilbert Gagne, Luc Laperriere, Jennifer Shalala, Janelle Danchuk, Catherine Barrette, Lydia Lauzon, Natalie Langille, Sarah Gagné, Joanie Lupien, Raphael Brochu, Sophie Coallier, Catherine Vaillancourt, Pierre Lachance, Diane Carbonneau, Helene Thibault, Luc Bouchard, Andreanne St-Cyr, Johanne Rioux, Laureanne Quenneville, Constance Gagnon, Theana Nony, Pascale Laberge, Annabelle Corbin, Isabelle Patry, Sophie Savage, Melanie MacNeil, Andrea Murdock, Jill Inglis, Katelyn Libbus, Kathryn Smith, Deseray Johnson, Linda Walters-Findlay, Laura Harris, Taylor Hutchison, Autumn Rafuse, Julie Thorsen, Greg MacDonald, Ronald Akhras, Richard Assef, Elise Irani, Rania Khayat, Scott Guidolin, Anil Gupta, David Price, Amisha Gandhi, Ajay Chhabra, Bhavya Gandhi, Shrey Acharya, Maheshwari Panchal, Bindu Kansal, Gordon Bailey, Paula Harvalik, Kerri Demchuk, Manish Saxena, David Collier, Colvell David, Benildo Jr Quiros, Mital Patel, Armida Balawon, Francis Galera, Ania Michalska, Brian Piniera, Rahat Uddin, Joanna Abbott, Karen Faulkner, Tamer Yousef, Kyle Love, Ariella Zagdanski, Susan Slaney, Michelle Anderson, Aimee Leath, Cheryl Dunlop, Elizabeth Hardy, Shannon Wall, Osman El-Koubani, Tracy Kelt, Billy-Jean Connolly, Cheryl Marmion, Maheswari Alapati, Louise Simmons, Caroline Colquhoun, Darren Clyde, Adrian Mooty, Nicole Mullen, Marianne Viljoen, Lucy Trevor, Carol Pretswell, Catherine Austin, Chigomezgo Munthali, Imrozia Munsoor, Madhu Venkate Gowda, Pembe Ozunlu, Peter Keighley, Alison Jones, Annette James, Joanne Pollitt, Wendy Littlewood, Lena Al-Sheikhly, David Lee, Denise Nistor, Elaine Roberts, Gayle Mawdsley, Kamila Sobolewska, Katrina Hannis, Klaudia Wojtkiewicz, Lauren Stopford, Lindsay Halliwell, Veronica Mort, Victoria McGrath, Harry Osborne, Alison Merrick, Cathrine Basikolo, Inge Ghysels, Laura Fenlon, Lucy Beech, Olga Lusquinos Munoz, Sarah Bilton, Lyne Goddard, Tracey Gillon, Stacy Taylor, Brianne Tyson, Victoria Connor, Hannah Felber, Angela Fallows, Jacqueline Clowes, Shirley Cheung
Journal: JAMA (2024)

Angiotensinogen is the most upstream precursor of the renin-angiotensin-aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotensinogen synthesis.