tbuckley/cabot-search huggingface dataset:
Abstract 1731: Social Support, Personal Control, and Psychological Functioning Among Individuals with Heart Failure
Authors: Melissa V Taylor, Patricia Bohachick, Susan M Sereika, Elizabeth A Schlenk, Charlotte Brown, Lora E Burke
Journal: Circulation (2007)

Heart failure places a large psychosocial burden on patients and their families. Although psychological functioning generally improves for most cardiac patients, impairment persists for a significant minority, posing a serious impediment to well-being. It has been proposed that personal resources, such as social support and coping style, facilitate adaptation to such threatening events as chronic illness, and thus impact psychological outcomes. Purpose: The primary aim of this study was to develop and test two mediating models, drawn on an integrative stress coping framework. The models considered the complex relationships between social support and personal control and two key psychological outcomes, depressive symptoms and anxiety, in individuals coping with heart failure. Social support was hypothesized to have a direct effect on depressive symptoms (Model 1) and anxiety (Model 2), and an indirect effect, mediated by personal control, on these psychological outcomes. Methods: We conducted a secondary analysis of data collected from a cross-sectional survey of patients (N = 242) between 21 and 82 years of age being treated primarily for idiopathic (55.8%) or ischemic (39.7%) cardiomyopathy. Structural equation modeling was used to test the hypotheses. Results: Both models demonstrated good data model fit, with 52% of the variance explained for Model 1 and 38% of the variance explained for Model 2. Statistically significant estimates indicated that social support plays a key role in reducing depressive symptoms and anxiety. Notably, for each model, the mechanism whereby social support reduces psychological distress is entirely through the indirect effect, i.e., through patients’ perceived control. Conclusions: The results provide support for existing theories that emphasize important roles of social support and personal control in improving psychological functioning among the chronically ill. This study raises the possibility that strategies designed to improve social support can be useful in reducing heart failure patients’ depressive symptomatology and anxiety. Such strategies would operate primarily through improving one’s sense of personal control. #
Abstract 2430: Should All Octogenarians Who Meet Criteria Receive an Implantable Cardioverter Defibrillator?
Authors: Kavita Phatak, Kevin Makati, Marian Holland, Sara Baig, Michael H Kim, Mark Link, Rod Passman
Journal: Circulation (2007)

Background: There are no upper age restrictions for ICD implantation, though guidelines state that placement should be reserved for those with expected survival of &gt; 1 year. In octogenarians, competing comorbidities may limit the mortality benefit of ICDs. Methods: A retrospective cohort study was used to identify octogenarians who received ICD implantation and follow-up at Northwestern Memorial Hospital or Tufts New England Medical Center between 1990 and 2006. The primary endpoint was death within 1 year of implant. Results: The study identified 241 octogenarians. Mean age 83.3 ± 3.1 years, 79% male, 87% coronary disease and 35% implanted for primary prophylaxis. Mean EF 31 ± 13%, creatinine 1.49 ± 0.71 mg/dl, and mean survival was 3.9 ± 0.3 years. Death within 1 year of implant occurred in 32 (13.2%) patients. Univariate predictors of 1-year mortality included EF ≤ 20% and creatinine ≥ 1.5 mg/dl (p &lt; 0.01 and 0.04, respectively). Cox proportional analysis demonstrated that EF ≤ 20% was the only independent predictor of death within 1 year of ICD implant [Hazard Ratio = 3.2 (95% CI 1.5– 6.5; p&lt;0.002)] and was associated with a 48% 1-year mortality. Of these patients, 6 (19%) received appropriate ICD therapy prior to death; the mean time from therapy to death was 3 months. Conclusion: Octogenarians with EF ≤ 20% have a very high 1-year mortality despite ICD implantation. A minority of these patients will receive appropriate ICD therapy during this time. These results would be expected to have significant impact on the cost-effectiveness of ICDs and should be considered when evaluating device implantation in this population.
Abstract 10077: Intra-Arterial Administration of Bone Marrow Mononuclear Cells in Patients with Critical Limb Ischemia -- a Randomized-Start, Placebo-Controlled Trial (PROVASA)
Authors: Dirk H Walter, Hans Krankenberg, Jorn Balzer, Christoph Kalka, Iris Baumgartner, Michael Schlueter, Torsten Tonn, Florian Seeger, Stefanie Dimmeler, Edelgard Lindhoff-Last, Andreas M Zeiher
Journal: Circulation (2010)

Background: Injection of autologous bone marrow-derived mononuclear cells (BM-MNC) is a promising therapeutic option in patients with critical limb ischemia, but double-blind, randomized trials are...
Doppler-derived mitral deceleration time as a strong prognostic marker of left ventricular remodeling and survival after acute myocardial infarction
Authors: Pier L Temporelli, Pantaleo Giannuzzi, Gian L Nicolosi, Roberto Latini, Maria G Franzosi, Francesco Gentile, Luigi Tavazzi, Aldo P Maggioni
Journal: Journal of the American College of Cardiology (2004)
Abstract 3707: Selenium Concentration and Cardiovascular Events in Patients with Coronary Artery Disease
Authors: Christoph R Sinning, Edith Lubos, Renate Schnabel, Jan-Malte Sinning, Philipp S Wild, Tanja Zeller, Christoph Bickel, Christine Espinola-Klein, Karl J Lackner, Laurence Tiret, Thomas F Muenzel, Stefan Blankenberg
Journal: Circulation (2007)

Introduction: Selenium is an essential trace element with important antioxidative properties. The aim of this study was to evaluate the relative risk of cardiovascular mortality according to increasing concentrations of selenium and a possible protective effect of high selenium concentrations against oxidative stress in patients with established coronary artery disease. Methods: In this substudy of the prospective Athero Gene survey, 1867 patients were included. These patients could be stratified according to the diagnosis into stable angina pectoris (SAP, n=852), acute coronary syndrome (ACS, n=879) and exclusion of relevant coronary artery disease (NoCAD, n=123). Results: Low selenium concentration is associated with an increased relative risk for cardiovascular mortality. When the collective with ACS is stratified into tertiles of rising selenium concentration, the survival curves according to the Kaplan-Meier-Method (Log-Rank Test: P=0.0001) reveal an adverse outcome. In contrast, in patients with SAP was no association between the selenium concentration and outcome (P=0.35) had been observed. In a fully adjusted Cox proportional hazards model encompassing classical risk factors, medication and laboratory markers, thirds of increasing selenium concentration were associated with a protective effect in patients with ACS (tertiles: HR: 0.362, 95% CI: 0.149–0.878, P=0.025). In a Cox backward-stepwise regression analysis encompassing sixteen variables of cardiovascular risk prediction, one increment increase in selenium concentration decreased the risk of cardiovascular mortality in patients with ACS (HR:0.746, 95%CI: 0.602–0.926; P-Value: 0.008). Conclusion : Increased selenium concentration is related to an improved outcome after the acute event. This data encourages the concept of selenium administration in patients with ACS.
ACCF 2012 Expert Consensus Document on Practical Clinical Considerations in the Interpretation of Troponin Elevations
Authors: L. Kristin Newby, Robert L. Jesse, Joseph D. Babb, Robert H. Christenson, Thomas M. De Fer, George A. Diamond, Francis M. Fesmire, Stephen A. Geraci, Bernard J. Gersh, Greg C. Larsen, Sanjay Kaul, Charles R. McKay, George J. Philippides, William S. Weintraub, Robert A. Harrington, Deepak L. Bhatt, Jeffrey L. Anderson, Eric R. Bates, Charles R. Bridges, Mark J. Eisenberg, Victor A. Ferrari, John D. Fisher, Mario J. Garcia, Timothy J. Gardner, Federico Gentile, Michael F. Gilson, Adrian F. Hernandez, Mark A. Hlatky, Alice K. Jacobs, Sanjay Kaul, Jane A. Linderbaum, David J. Moliterno, Debabrata Mukherjee, Robert S. Rosenson, James H. Stein, Howard H. Weitz, Deborah J. Wesley
Journal: Journal of the American College of Cardiology (2012)

This document has been developed as an Expert Consensus Document (ECD) by the American College of Cardiology Foundation (ACCF), American Association for Clinical Chemistry (AACC), American College of Chest Physicians (ACCP), American College of Emergency Physicians (ACEP), American College of
Association Between Angiographic Complications During Percutaneous Coronary Intervention and Clinical Outcomes Among Patients with Acute Coronary Syndrome: An EARLY ACS Angiographic Substudy
Authors: Kunadian, YB Pride, S Mohanavelu, RP Giugliano, LK Newby, C Zorkun, E Braunwald, RM Califf, RA Harrington, CM Gibson
Journal: Circulation (2011)
A new concept and finding in morbid jealousy
Authors: J P Docherty, J Ellis
Journal: American Journal of Psychiatry (1976)

The authors describe an unexpected coincidental finding in three couples who sought therapy because the husband was pathologically jealous. In the course of treatment they found that during early adolescence each of these men had witnessed his mother engaged in extramarital sexual activity. The authors discuss the implications of this finding for further understanding of the etiology of the syndrome of pathological jealousy, its transactional dimensions, and possible psychotherapeutic approaches. They also present a typology of morbid jealousy that consists of excessive obsessional-delusional, and ego dysfunctional forms.
Abstract 15103: Total Adiponectin and Its High Molecular Weight Oligomer Are Associated with The Increase in HDL-Cholesterol Observed with Improved Lifestyle in Obese Diabetic Persons: Findings From the Look Ahead (Action for Health in Diabetes) Study
Authors: L Maria Belalcazar, Steven M Haffner, Wei Lang, Ron C Hoogeveen, Ashok Balasubramanyam, Dawn C Schwenke, F. Xavier Pi-Sunyer, Russell P Tracy, Christie M Ballantyne
Journal: Circulation (2011)

Background: A few intervention trials indicate that weight loss in non-diabetic subjects, achieved either through lifestyle behavior change or bariatric/gastric device intervention, results in an i...
Familial relatedness of schizophrenia and schizotypal states
Authors: Miron Baron, Rhoda Gruen, Lauren Asnis, John M. Kane
Journal: American Journal of Psychiatry (1983)

The types and expectancy of mental disorders in the siblings of 74 probands with chronic schizophrenia were examined. The siblings were classified according to whether 1) both parents had schizotypal personality disorder, 2) one parent had the disorder and one was normal, or 3) both parents were normal. Siblings whose parents both had the disorder were at significantly greater risk for schizophrenia and schizotypal personality disorder than siblings with at least one normal parent. Similarly, the expectancy of schizotypal personality disorder alone and combined with schizophrenia was higher among siblings with one parent with the disorder than in siblings with two normal parents. The data suggest that schizotypal traits may be genetically related to schizophrenia.
Abstract 1047: Anti-proteolytic Effects of Exercise Training in the Skeletal Muscle of Chronic Heart Failure Patients: Does Exercise Work Equally Well in All Age Groups?
Authors: Stephan Gielen, Marcus Sandri, Volker Adams, Norman Mangner, Irina Kozarez, Sandra Erbs, Axel H Linke, Rainer P Hambrecht, Gerhard C Schuler
Journal: Circulation (2009)
Persisting Incidence and Mortality of Sinogenic Cerebral Abscess: A Continuing Reflection of Late Clinical Diagnosis
Authors: S Chalstrey, A G Pfleiderer, D A Moffat
Journal: Journal of the Royal Society of Medicine (1991)

Seventy-four verified cases of cerebral abscess seen in the Regional Neurosurgical Centre at Addenbrookes Hospital, Cambridge between 1965 and 1987 were reviewed. During that time no decline in incidence or change in the associated mortality was found to occur. ENT disease, taken as a whole, represented the most common source (40%) while acute frontal sinusitis (23%) proved to be the most common single underlying cause. Cerebral abscesses of sinogenic origin in particular were diagnosed late, with a deteriorating conscious level being the precipitating event in 94% of cases. Over 80% of such patients had presented initially to a non-ENT department with acute frontal headache where neither the underlying frontal sinusitis nor the developing intracranial complication had been suspected. These findings might explain why the incidence and mortality associated with cerebral abscesses of sinogenic origin, have changed little in the last 25 years despite improvements in diagnostic imaging, surgical technique and antibiotic therapy. We recommend that the diagnosis of acute frontal sinusitis be considered in any patient who presents with acute frontal headache, particularly if symptoms are unilateral. Furthermore, we stress that early confirmation of intracerebral complications by computerized axial tomography (CT) scanning continues to depend entirely upon an early clinical diagnosis which should result from a high level of clinical suspicion in patients who develop intracranial symptoms in the presence of known acute frontal sinus infection.
Abstract 981: Hypoxia Results in Exacerbation of Pulmonary Arterial Hypertension (PAH) in Male Mice with Deletion of PPARγin Smooth Muscle Cells (SMC) but Females are Protected by Adiponectin Mediated Induction of PPARα
Authors: Laura H Rubinos, Georg Hansmann, Nesrine El-Bizri, Christophe Guignabert, Vinicio A De Jesus Perez, Marlene Rabinovitch
Journal: Circulation (2007)

Lung tissues of patients with PAH have reduced levels of the peroxisome proliferator activated receptor gamma (PPARγ) and we previously reported that transgenic male mice with deletion of PPARγ in arterial smooth muscle (SM22CrePPARγ flox/flox ) develop spontaneous PAH. Moreover, PPARγ is necessary in mediating bone morphogenetic protein (BMP-2) inhibition of PDGF-BB induced SMC proliferation. We therefore hypothesized that PAH would be exacerbated in SM22CrePPARγ flox/flox mice under conditions like chronic hypoxia (3 weeks, FiO 2 =0.10) that induce PDGF-BB mediated SMC proliferation. Results: Consistent with this hypothesis, we report a more severe PAH phenotype only in the male SM22CrePPARγ flox/flox mice, as measured by greater right ventricular systolic pressure (RVSP: 38.6 vs. 30.9 mmHg), right ventricular hypertrophy (RVH=right ventricle/left ventricle+septum: 0.58 vs 0.35), and arterial muscularization (90.6 vs 60.3 %), when compared to littermate controls (p&lt;0.05, n=6 – 8 per group, for all comparisons). Interestingly, female SM22CrePPARγ flox/flox mice were resistant to spontaneous or chronic hypoxia-induced PAH (RVSP: 18.5mmHg). We investigated the acute hypoxic vasoconstrictive response and found it exaggerated in the male but suppressed in the female (RVSP: 43.12 vs 20.42mmHg) SM22CrePPARγ flox/flox mice. We found no reduction in endothelin-1 (P&lt;0.05) in the female vs. male SM22CrePPARγ flox/flox mice but serum levels of adiponectin were twofold higher (14.5 vs 6.9 μg/ml; p&lt;0. 001) in females under normoxia and hypoxia. We further show through cell counts, that in pulmonary artery (PA) SMC from male SM22CrePPARγ flox/flox mice, BMP2 fails to suppress PA SMC proliferation in response to PDGF-BB (p&lt;0.01; n=3) but exogenous adiponectin can ‘rescue’ this phenotype (p&lt;0.01, n=3). The mechanism appears to be related to adiponectin mediated induction of PPAR alpha (PPARγ mRNA relative level: 0.37 vs 0.42 after adiponectin pretreatment, p&lt;0.01), which we report for the first time in PA SMC. Conclusion : These findings strengthen the potential efficacy of PPAR-α/ γ agonists in the treatment of PAH patients with low endogenous levels of PPAR-γ and/or adiponectin, such as those with BMP-RII dysfunction or insulin resistance.
Abstract 13947: Targeting DNA Repair to Prevent Athracycline-induced Cardiac Failure
Authors: Praphulla C Shukla, Krishna K Singh, Adrian Quan, Yi Pan, Mohammed Al-Omran, Fina Lovren, Howard Leong-Poi, Hwee Teoh, Subodh Verma
Journal: Circulation (2010)

Anthracycline-based treatment approaches are associated with cardiac dysfunction and remain a significant unmet clinical problem. We hypothesized that strategies aimed at improving DNA repair will ...
Abstract 1529: Predictive Values of a New Risk Score (C-AMI) in ST-Segment Elevation Myocardial Infarction.
Authors: Thao Huynh, Andrew Yan, Simon Kouz, Stephane Rinfret, Erick Schampaert, Mark J Eisenberg, Claude Lauzon, Marc Afilalo, Shaun Goodman
Journal: Circulation (2007)
Abstract 3775: Average Blood Glucose and Mortality in Patients Hospitalized with Acute Myocardial Infarction
Authors: Mikhail Kosiborod, Silvio Inzucchi, Harlan M Krumholz, Lan Xiao, Phillip G Jones, Suzanne Fiske, Frederick A Masoudi, Steven P Marso, John A Spertus
Journal: Circulation (2007)

Background: Elevated blood glucose (BG) on admission is associated with higher mortality risk in patients (pts) hospitalized with AMI. However, the prognostic value of average BG, which reflects overall glycemic exposure much better than admission BG, is unknown. Furthermore, the nature of the relationship between average BG and mortality has not been determined. Methods: We evaluated a cohort of 16,871 AMI pts hospitalized from January 2000-December 2005, using Cerner Corporation’s Health Facts® database from 40 hospitals, which contains demographics, clinical and comprehensive laboratory data. Logistic regression models evaluated the nature of the relationship between mean BG during the entire AMI hospitalization and in-hospital mortality, after adjusting for multiple patient factors and confounders. Similar analyses were performed in subgroups of pts with and without diabetes (DM). Results: A J-shaped relationship was observed between mean BG and in-hospital mortality, which persisted after multivariable adjustment (Figure ). Mortality increased with each 10 mg/dL incremental rise in mean BG over &gt;120 mg/dL, and with incremental decline in mean BG &lt;80 mg/dL. The slope of these relationships was much steeper in pts without DM. Conclusions: Average BG during the entire AMI hospitalization is a powerful independent predictor of in-hospital mortality. Both persistent hyper- and hypoglycemia are associated with adverse prognosis. Whether strategies directed at optimizing BG control will improve survival remains to be established. Association Between Mean BG and In-Hospital Mortality After Multivariable Adjustment (Reference: Mean BG 100 to &lt;110)
Painful diabetic neuropathy
Authors: 聡 桑原, 周一 石井, 博 鴨下, 虎雄 竹谷
Journal: BMJ (2014)

Most importantly, in the abstract section, type 1 diabetes and type 2 were switched in the text of the seventh sentence so that it now correctly reads: "Enhanced glucose control is much more effective at preventing neuropathy in patients with type 1 diabetes than in those with type 2 disease."In addition, in the text and figure 2 we clarified "calcium channel blockers" as "antiepileptic drugs that block calcium channels.
Practical Bacteriology, Blood Work and Animal Parasitology, Including Bacteriological Keys, Zoological Tables and Explanatory Clinical Notes. A Compendium for Internists.
Authors: E. R. Stitt
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 593: Hypoxia is Present in the Macrophage-rich Center of Human Carotid Atherosclerotic Plaques
Authors: Judith C Sluimer, Job L van Wanroij, Matthijs Groeneweg, Bradly G Wouters, Mat J Daemen, Ann-Pascale J Bijnens
Journal: Circulation (2007)

Intraplaque neovascularization is linked to plaque instability and thought to be stimulated by hypoxia. However, hypoxia has not been demonstrated yet in human atherosclerosis. The hypoxia marker pimonidazole was administrated intravenously 2 hours prior to carotid endarterectomy in 6 symptomatic patients to evaluate the presence of hypoxia. Subsequent immunohistochemistry of the operatively removed atherosclerotic plaques demonstrated the presence of hypoxia, especially in the macrophage-rich center of the lesions. Notably, two hypoxic gradients were observed: hypoxia was very strong in the center of the plaque, but almost absent close to the main artery lumen and in the media. hypoxia was most intense in segments with advanced atheroma and almost absent in segments containing only diffuse intimal thickening. Hypoxia strongly correlated with CD68 immunoreactivity (ρ= 0.7, p=0.000), neovascularization (ρ= 0.6, p=0.000) and the presence of a thrombus (ρ= 0.4, p=0.009). In addition, hypoxia co-localized with expression of HIF1α and VEGF . To exclude that pimonidazole immunoreactivity in the atherosclerotic plaque was the result of surgery-induced ischemia, arterial wall segments were collected at two time-points: directly after incision of the carotid artery and directly following excision of the plaque. Pimonidazole immunoreactivity in these two pieces was not different, suggesting that hypoxia and pimonidazole adducts were already present in the plaques before surgery . To show that pimonidazole reactivity was hypoxia-specific and independent of reactive oxygen species, human THP-1 macrophages were exposed to normoxia (20% O 2 ), hypoxia (0.2% O 2 ) and/or H 2 O 2 (100 μM) in the presence of pimonidazole. Indeed, flow cytometry only showed pimonidazole-positive cells after hypoxic exposure. This is the first study proving direct evidence of the existence of hypoxia in advanced human atherosclerotic lesions, most prominently in the macrophage-rich center. Also, hypoxia was associated with the expression of HIF1α, VEGF and intraplaque microvessels, suggesting its involvement in the regulation of human intraplaque neovascularization.
Abstract 17555: The Diagnostic and Prognostic Value of Myocardial Fibrosis in Nonischemic Dilated Cardiomyopathy: A Study by Endomyocardial Biopsy and Cardiac Magnetic Resonance
Authors: Martina Perazzolo Marra, Manuel De Lazzari, Stefania Rizzo, Filippo Zilio, Giulia Vettor, Chiara Calore, Benedetta Giorgi, Francesco Tona, Luisa Cacciavillani, Giuseppe Tarantini, Diego Miotto, Gaetano Thiene, Domenico Corrado, Sabino Iliceto, Cristina Basso
Journal: Circulation (2013)

Purpose: Non-ischemic dilated cardiomyopathy (DCM) is characterized by fibrotic changes beyond myocite vacualization and nuclear abnormalities. While the diagnostic value of endomyocardial fibrosis...