POS0933 THE FREQUENCY OF AORTIC AND MITRAL VALVE INVOLVEMENT IN PATIENTS WITH TAKAYASU ARTERITIS
Authors: M. E. Kutu, F. Tastekin, D. Kerim, T. Ocak, S. San, F. Yildirim, H. Kocaayan, S. Isik, G. Kenar, A. Avcu, B. C. Uludogan, S. Celik, K. Aksu, G. Keser, Y. Pehlivan, A. Cefle, A. Yazici, C. Bes, S. Akar, A. Omma, F. Onen, H. Direskeneli, F. Alibaz- Oner, N. S. Yasar Bilge, N. A. Kanitez
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> A significant portion of Takayasu arteritis (TA) patients have cardiac valvular involvement, and it is reported that the affected valve is usually the aortic [1, 2]. Cardiac valve involvement often leads to insufficiency and progressive deterioration in valve functions negatively affects disease outcomes. Involvement of the ascending aorta is known as a risk factor for aortic valve (AV) insufficiency. However, more data on risk factors and prognosis are needed. <h3>Objectives:</h3> The aim of this study is to determine the frequency and risk factors of AV and mitral valve (MV) involvement in a large cohort of TA patients. <h3>Methods:</h3> Subjects who were diagnosed with TA according to ACR criteria and had echocardiography performed at baseline, from 11 rheumatology centers in Türkiye were included in this study. Patients with acute rheumatic fever and congenital cardiac valvular disease were excluded. Clinical, laboratory and echocardiography data were obtained from outpatient polyclinic files. <h3>Results:</h3> A total of 199 patients, 177 (89%) of whom were female and the mean age was 32.9±12.5 years, were analyzed. According to the "Numano classification", Type 5 (37%) and Type 1 (24%) were the first two radiological types in terms of frequency. Insufficiency was the most common valve involvement pattern. Of the patients who underwent echocardiography, 85 (43%) had MV and 68 (34%) had AV insufficiency. The MV and AV insufficiency was moderate-severe in 4 (5%) and 10 (28%) patients, respectively. Congestive heart failure was found to be statistically significantly higher in the group with AV insufficiency (p=0.03) (Table 1). <h3>Conclusion:</h3> According to the results of our study, the most common cardiac valve pathology is MV insufficiency in TA patients. However, since mild MV insufficiency can also be seen in the normal population in women of childbearing age, AV insufficiency may be clinically more important. Moreover, the rate of heart failure is higher in the group with AV insufficiency. The fact that the frequency of AV insufficiency was not statistically significant in radiological Type 2 and Type 5 suggested that the pathogenesis could not be explained only by involvement of the ascending aorta. ata recording is ongoing and the prognosis of AV and MV involvement will also be evaluated. In our study, data collection and analysis are still ongoing. <h3>REFERENCES:</h3> [1] Ren Y, Du J, Guo X, Liu O, Liu W, Qi G, Pan L. Cardiac valvular involvement of Takayasu arteritis. Clin Rheumatol. 2021 Feb;40(2):653-660. [2] Li J, Li H, Sun F, Chen Z, Yang Y, Zhao J, Li M, Tian X, Zeng X. Clinical Characteristics of Heart Involvement in Chinese Patients with Takayasu Arteritis. J Rheumatol. 2017 Dec;44(12):1867-1874. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>