tbuckley/cabot-search huggingface dataset:
Multi-modal analysis reveals tumor and immune features distinguishing EBV-positive and EBV-negative post-transplant lymphoproliferative disorders
Authors: Jiaying Toh, Andrea J Reitsma, Tetsuya Tajima, Sheren F Younes, Chimere Ezeiruaku, Kayla C Jenkins, Josselyn K Peña, Shuchun Zhao, Xi Wang, Esmond Y Z Lee, Marla C Glass, Laurynas Kalesinskas, Ananthakrishnan Ganesan, Irene Liang, Joy A Pai, James T Harden, Francesco Vallania, Edward A Vizcarra, Govind Bhagat, Fiona E Craig, Steven H Swerdlow, Julie Morscio, Daan Dierickx, Thomas Tousseyn, Ansuman T Satpathy, Sheri M Krams, Yasodha Natkunam, Purvesh Khatri, Olivia M Martinez
Journal: Cell Reports Medicine (2024)
A glucocorticoid spike derails muscle repair to heterotopic ossification after spinal cord injury
Authors: Kylie A Alexander, Hsu-Wen Tseng, Hong Wa Lao, Dorothée Girard, Valérie Barbier, Jacobus P J Ungerer, Brett C McWhinney, Selwin G Samuel, Whitney Fleming, Ingrid G Winkler, Marjorie Salga, François Genêt, Sébastien Banzet, Marc J Ruitenberg, Jean-Pierre Lévesque
Journal: Cell Reports Medicine (2024)
Miltefosine reinvigorates exhausted T cells by targeting their bioenergetic state
Authors: Xingying Zhang, Chenze Zhang, Shan Lu, Jingxi Dong, Na Tang, Yao Wang, Weidong Han, Xi Pan, Xiang Zhang, Duan Liu, Ng Shyh-Chang, Yu Wang, Guihai Feng, Haoyi Wang
Journal: Cell Reports Medicine (2024)
Development and validation of the utLIFE-PC algorithm for noninvasive detection of prostate cancer in urine: A prospective, observational study
Authors: Sujun Han, Mingshuai Wang, Yong Wang, Junlong Wu, Zhaoxia Guo, Huina Wang, Ranlu Liu, Xiaofu Qiu, Linjun Hu, Jianbin Bi, Weigang Yan, Hengqing An, Gejun Zhang, Yi Zhi, Zhiyuan Chen, Libin Chen, Lei Liu, Huanqing Cheng, Shuaipeng Zhu, Meng Wang, Yanrui Zhang, Xiao Liu, Feng Lou, Shanbo Cao, Dingwei Ye, Yuanjie Niu, Nianzeng Xing
Journal: Cell Reports Medicine (2024)
A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver
Authors: Andrew S Perry, Niran Hadad, Emeli Chatterjee, Maria Jimenez-Ramos, Eric Farber-Eger, Rashedeh Roshani, Lindsey K Stolze, Michael J Betti, Shilin Zhao, Shi Huang, Liesbet Martens, Timothy J Kendall, Tinne Thone, Kaushik Amancherla, Samuel Bailin, Curtis L Gabriel, John Koethe, J Jeffrey Carr, James Greg Terry, Nataraja Sarma Vaitinadin, Jane E Freedman, Kahraman Tanriverdi, Eric Alsop, Kendall Van Keuren-Jensen, John F K Sauld, Gautam Mahajan, Sadiya S Khan, Laura Colangelo, Matthew Nayor, Susan Fisher-Hoch, Joseph B McCormick, Kari E North, Jennifer E Below, Quinn S Wells, E Dale Abel, Ravi Kalhan, Charlotte Scott, Martin Guilliams, Eric R Gamazon, Jonathan A Fallowfield, Nicholas E Banovich, Saumya Das, Ravi Shah
Journal: Cell Reports Medicine (2024)
Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuit
Authors: Ilya S Senatorov, Joel Bowman, Keith H Jansson, Aian Neil Alilin, Brian J Capaldo, Ross Lake, Morgan Riba, Yasmine C Abbey, Crystal Mcknight, Xiaohu Zhang, Sonam Raj, Michael L Beshiri, Paul Shinn, Holly Nguyen, Craig J Thomas, Eva Corey, Kathleen Kelly
Journal: Cell Reports Medicine (2024)
16. Diabetes Care in the Hospital: Standards of Care in Diabetes—2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Kirthikaa Balapattabi, Elizabeth A. Beverly, Kathaleen Briggs Early, Dennis Bruemmer, Justin B. Echouffo-Tcheugui, Laya Ekhlaspour, Rodolfo J. Galindo, Rajesh Garg, Kamlesh Khunti, Rayhan Lal, Ildiko Lingvay, Glenn Matfin, Naushira Pandya, Elizabeth J. Pekas, Scott J. Pilla, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Robert C. Stanton, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes—2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Kirthikaa Balapattabi, Elizabeth A. Beverly, Kathaleen Briggs Early, Dennis Bruemmer, Brian C. Callaghan, Justin B. Echouffo-Tcheugui, Laya Ekhlaspour, Robert G. Frykberg, Rajesh Garg, Sunir J. Garg, John M. Giurini, Kamlesh Khunti, Rayhan Lal, Ildiko Lingvay, Glenn Matfin, Naushira Pandya, Elizabeth J. Pekas, Scott J. Pilla, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Robert C. Stanton, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes—2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Kirthikaa Balapattabi, Elizabeth A. Beverly, Briggs Early, Dennis Bruemmer, Justin B. Echouffo-Tcheugui, Laya Ekhlaspour, Rajesh Garg, Kamlesh Khunti, Rayhan Lal, Ildiko Lingvay, Glenn Matfin, Naushira Pandya, Elizabeth J. Pekas, Scott J. Pilla, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Elizabeth Selvin, Robert C. Stanton, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)

The American Diabetes Association (ADA) “Standards of Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes: Standards of Care in Diabetes—2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Kirthikaa Balapattabi, Elizabeth A. Beverly, Kathaleen Briggs Early, Dennis Bruemmer, Justin B. Echouffo-Tcheugui, Barbara Eichorst, Laya Ekhlaspour, Rajesh Garg, Mohamed Hassanein, Kamlesh Khunti, Rayhan Lal, Ildiko Lingvay, Glenn Matfin, Roeland J.W. Middelbeek, Naushira Pandya, Elizabeth J. Pekas, Scott J. Pilla, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Robert C. Stanton, Molly L. Tanenbaum, Patti Urbanski, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes—2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Kirthikaa Balapattabi, Elizabeth A. Beverly, Kathaleen Briggs Early, Dennis Bruemmer, Justin B. Echouffo-Tcheugui, Laya Ekhlaspour, Rajesh Garg, Kamlesh Khunti, Rayhan Lal, Ildiko Lingvay, Glenn Matfin, Naushira Pandya, Elizabeth J. Pekas, Scott J. Pilla, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Robert C. Stanton, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
13. Older Adults: Standards of Care in Diabetes—2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Kirthikaa Balapattabi, Elizabeth A. Beverly, Kathaleen Briggs Early, Dennis Bruemmer, Justin B. Echouffo-Tcheugui, Laya Ekhlaspour, Rajesh Garg, Kamlesh Khunti, Rayhan Lal, Ildiko Lingvay, Glenn Matfin, Nicola Napoli, Naushira Pandya, Elizabeth J. Pekas, Scott J. Pilla, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Robert C. Stanton, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
14. Children and Adolescents: Standards of Care in Diabetes—2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Kirthikaa Balapattabi, Elizabeth A. Beverly, Kathaleen Briggs Early, Dennis Bruemmer, Justin B. Echouffo-Tcheugui, Laya Ekhlaspour, Rajesh Garg, Kamlesh Khunti, Rayhan Lal, Ildiko Lingvay, Glenn Matfin, Naushira Pandya, Elizabeth J. Pekas, Scott J. Pilla, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Shylaja Srinivasan, Robert C. Stanton, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)

The American Diabetes Association (ADA) “Standards of Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Summary of Revisions: Standards of Care in Diabetes—2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Mandeep Bajaj, Kirthikaa Balapattabi, Elizabeth A. Beverly, Kathaleen Briggs Early, Dennis Bruemmer, Brian C. Callaghan, Kenneth Cusi, Sandeep R. Das, Osagie Ebekozien, Justin B. Echouffo-Tcheugui, Barbara Eichorst, Laya Ekhlaspour, Talya K. Fleming, Robert G. Frykberg, Jason L. Gaglia, Rodolfo J. Galindo, Rajesh Garg, Sunir J. Garg, Monica Girotra, John M. Giurini, Mohamed Hassanein, Kamlesh Khunti, Mikhail N. Kosiborod, Robert F. Kushner, Rayhan Lal, Seymour R. Levin, Ildiko Lingvay, Glenn Matfin, Roeland J.W. Middelbeek, Lisa Murdock, Nicola Napoli, Joshua J. Neumiller, Naushira Pandya, Sharon J. Parish, Elizabeth J. Pekas, Scott J. Pilla, Flavia Q. Pirih, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Elizabeth Selvin, Shylaja Srinivasan, Robert C. Stanton, Molly L. Tanenbaum, Patti Urbanski, Monica Verduzco-Gutierrez, Crystal C. Woodward, Zobair M. Younossi, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)
Neuroinflammation in Alzheimer disease
Authors: Michael T. Heneka, Wiesje M. van der Flier, Frank Jessen, Jeroen Hoozemanns, Dietmar Rudolf Thal, Delphine Boche, Frederic Brosseron, Charlotte Teunissen, Henrik Zetterberg, Andreas H. Jacobs, Paul Edison, Alfredo Ramirez, Carlos Cruchaga, Jean-Charles Lambert, Agustin Ruiz Laza, Jose Vicente Sanchez-Mut, Andre Fischer, Sergio Castro-Gomez, Thor D. Stein, Luca Kleineidam, Michael Wagner, Jonas J. Neher, Colm Cunningham, Sim K. Singhrao, Marco Prinz, Christopher K. Glass, Johannes C. M. Schlachetzki, Oleg Butovsky, Kilian Kleemann, Philip L. De Jaeger, Hannah Scheiblich, Guy C. Brown, Gary Landreth, Miguel Moutinho, Jaime Grutzendler, Diego Gomez-Nicola, Róisín M. McManus, Katrin Andreasson, Christina Ising, Deniz Karabag, Darren J. Baker, Shane A. Liddelow, Alexei Verkhratsky, Malu Tansey, Alon Monsonego, Ludwig Aigner, Guillaume Dorothée, Klaus-Armin Nave, Mikael Simons, Gabriela Constantin, Neta Rosenzweig, Alberto Pascual, Gabor C. Petzold, Jonathan Kipnis, Carmen Venegas, Marco Colonna, Jochen Walter, Andrea J. Tenner, M. Kerry O’Banion, Joern R. Steinert, Douglas L. Feinstein, Magdalena Sastre, Kiran Bhaskar, Soyon Hong, Dorothy P. Schafer, Todd Golde, Richard M. Ransohoff, David Morgan, John Breitner, Renzo Mancuso, Sean-Patrick Riechers
Journal: Nature reviews. Immunology (2024)
7. Diabetes Technology: Standards of Care in Diabetes—2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Kirthikaa Balapattabi, Elizabeth A. Beverly, Kathaleen Briggs Early, Dennis Bruemmer, Justin B. Echouffo-Tcheugui, Laya Ekhlaspour, Rajesh Garg, Kamlesh Khunti, Rayhan Lal, Ildiko Lingvay, Glenn Matfin, Naushira Pandya, Elizabeth J. Pekas, Scott J. Pilla, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Robert C. Stanton, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)

The American Diabetes Association (ADA) “Standards of Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
17. Diabetes Advocacy: Standards of Care in Diabetes—2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Kirthikaa Balapattabi, Elizabeth A. Beverly, Kathaleen Briggs Early, Dennis Bruemmer, Justin B. Echouffo-Tcheugui, Laya Ekhlaspour, Rajesh Garg, Kamlesh Khunti, Rayhan Lal, Ildiko Lingvay, Glenn Matfin, Lisa Murdock, Naushira Pandya, Elizabeth J. Pekas, Scott J. Pilla, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Robert C. Stanton, Crystal C. Woodward, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)

The American Diabetes Association (ADA) “Standards of Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Care in Diabetes—2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Mandeep Bajaj, Kirthikaa Balapattabi, Elizabeth A. Beverly, Kathaleen Briggs Early, Dennis Bruemmer, Kenneth Cusi, Justin B. Echouffo-Tcheugui, Laya Ekhlaspour, Talya K. Fleming, Rajesh Garg, Kamlesh Khunti, Rayhan Lal, Seymour R. Levin, Ildiko Lingvay, Glenn Matfin, Nicola Napoli, Naushira Pandya, Sharon J. Parish, Elizabeth J. Pekas, Scott J. Pilla, Flavia Q. Pirih, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Robert C. Stanton, Monica Verduzco-Gutierrez, Zobair M. Younossi, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)
3. Prevention or Delay of Diabetes and Associated Comorbidities: Standards of Care in Diabetes—2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Kirthikaa Balapattabi, Elizabeth A. Beverly, Kathaleen Briggs Early, Dennis Bruemmer, Osagie Ebekozien, Justin B. Echouffo-Tcheugui, Laya Ekhlaspour, Jason L. Gaglia, Rajesh Garg, Kamlesh Khunti, Rayhan Lal, Ildiko Lingvay, Glenn Matfin, Naushira Pandya, Elizabeth J. Pekas, Scott J. Pilla, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Robert C. Stanton, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
8. Obesity and Weight Management for the Prevention and Treatment of Type 2 Diabetes: Standards of Care in Diabetes–2025
Authors: Nuha A. ElSayed, Rozalina G. McCoy, Grazia Aleppo, Kirthikaa Balapattabi, Elizabeth A. Beverly, Kathaleen Briggs Early, Dennis Bruemmer, Justin B. Echouffo-Tcheugui, Laya Ekhlaspour, Rajesh Garg, Kamlesh Khunti, Robert F. Kushner, Rayhan Lal, Ildiko Lingvay, Glenn Matfin, Naushira Pandya, Elizabeth J. Pekas, Scott J. Pilla, Sarit Polsky, Alissa R. Segal, Jane Jeffrie Seley, Robert C. Stanton, Raveendhara R. Bannuru
Journal: Diabetes Care (2024)

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations and a full list of Professional Practice Committee members, please refer to Introduction and Methodology. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Multi-omics reveals the immunological features and the immune checkpoint blockade potential of colorectal medullary carcinoma
Authors: Chao Liu, Haoyi Zou, Yuli Ruan, Lin Fang, Bojun Wang, Luying Cui, Tong Wu, Zhuo Chen, Tianjiao Dang, Ya Lan, Wenyuan Zhao, Chunhui Zhang, Hongxue Meng, Yanqiao Zhang
Journal: Clinical Cancer Research (2024)

Abstract Purpose: Colorectal medullary carcinoma (MeC) is extensive lymphocyte infiltration and is associated with an active immune response. However, studies to comprehensively explore the immune landscape and efficacy of immune checkpoint blockade (ICB) therapy in MeC are limited. Experimental Design: We screened 47 cases of MeC from the Harbin Medical University Cancer Hospital cohort. The immunologic characteristics of MeC were analyzed by targeted exon sequencing, NanoString nCounter gene expression sequencing, IHC, multiplexed immunofluorescence, and T-cell antigen receptor sequencing. An additional 47 patients with MeC who received ICB therapy were included in the retrospective analysis to verify the efficacy of immunotherapy. Results: Genomically, MeC tends to have a higher proportion of mismatch repair protein deficiency/microsatellite instability (MSI), ARID1A mutation, and ASCL2 amplification. Gene expression shows enriched immune response–related pathways while downregulating oncogenic pathways, such as glycolysis, epithelial–mesenchymal transition, and Wnt/β-catenin signaling. Further immune characterization showed that MeC showed advantages in antigen presentation, co-stimulatory molecules, effector molecules, immune checkpoints, and immune cell abundance. More importantly, both MSI and microsatellite-stable type MeC showed a similar state of high infiltration of immune cells, even better than MSI non-MeC. MeC infiltrated massive highly clonal immune cells, especially intraepithelial CD8+ T cells. In the retrospective cohort, there were 30 patients with MeC who received ICB therapy and achieved complete or partial response with an objective response rate of 63.8%, especially including 16 patients with microsatellite-stable colorectal cancer. Conclusions: MeC is a pathologic subtype with an active immune response and is a promising group for ICB therapy. This heightened immune response was not limited to the patients' microsatellite status.