tbuckley/cabot-search huggingface dataset:
Abstract 17084: Aspirin Influences Megakaryocytic Gene Expression Leading to Up-Regulation of Multidrug Resistance Protein 4 in Human Platelets
Authors: Fabio M Pulcinelli, Isabella Massimi, Elisabetta Trifirò, Lavinia Vittoria Lotti, Raffaella Guerriero
Journal: Circulation (2011)

Recently, we demonstrated that MRP4 over-expression, an organic anion cellular detoxifier, has a role for the reduced aspirin action in patients after by-pass surgery (JACC in press). In other cell lines Mrp4 induction is an adaptive response necessary to reduce intracellular organic anion toxicity or cholestasis. To understand if aspirin treatment induces MRP4 up-regulation in human platelets we studied its quantitative variations in human megakacaryoblastic cell line, Dami, in platelets from megakaryocytic culture and from two different populations, aspirin treated patients (Asp-patients) and healthy volunteers (HV), in-vitro and in-vivo treated with aspirin. MRP4 expression was evaluated by mRNA intracellular expression (Real-time, PCR analysis), protein expression (immunofluorescence-WesternBlot). Aspirin in-vitro treatment (50 microM for 48 h) enhances of about 70% and 93% induction in MRP4 mRNA expression in Dami cells (5.3±0.2 vs 3.1±0.5 ΔΔCt) and in platelets from megakaryocytic culture (0.081±0.028 vs 0.042 ±0.013 ΔΔCt) respectively. In human platelets we found an association between in-vivo Aspirin treatment and MRP4 mRNA expression; which was higher than HV if the patients were treated for more than 2 months (HV 0.049±0.005 n=50; &lt;1months 0.052±0.010 n=19; &gt;2months 0.070±0.007 n=50 ΔΔCt respectively). In addition, platelets from in-vivo aspirin treated HV (330 mg/die n.=5) present an enhancement of induction in MRP4 mRNA expression after 15 days while, after 7 days, it is similar to those obtained before the treatment (HV 0.042±0.013; 7 days 0.048±0.022; 15 days 0.085±0.029ΔΔCt). Immunofluorescence and immunoblot analysis confirm that aspirin enhances MRP4 expression after either in-vitro or in-vivo treatment. Thus, MRP4 over-expression was associated with aspirin treatment. This is the first evidence that aspirin treatment induces a protein up-regulation in human platelets.
The Pneumonokonioses (Silicosis): Bibliography and Laws
Authors: George Gilbert Davis, Ella Maude Salmonsen, Joseph Lewis Earlywine
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atlas of Mineralized Bone Histology.
Authors: H. H. Malluche, M.-C. Faugere
Journal: Annals of Internal Medicine (1987)

National Library of Medicine, Cataloging in Publication Drug Dosage Malluche, Hartmut H. The authors and the publisher have exerted every effort to ensure that Atlas of mineralized bone histology / Hartmut H. Malluche, drug selection and dosage set forth in this text are in accord with current Marie-Claude Faugere. Basel; New York: Karger, 1986. recommendations and practice at the time of publication. However, in Bibliography: p. view of ongoing research, changes in government regulations, and the conIncludes index. stant flow of information relating to drug therapy and drug reactions, the 1. Bone and Bones pathology atlases 2. Bone Diseases, Metabolic reader is urged to check the package insert for each drug for any change in pathology atlases 3. Minerals metabolism atlases I. Title indications and dosage and for added
Die Schädigungen der Haut durch Beruf und gewerbliche Arbeit.
Authors: Karl Ullmann, Moritz Oppenheim, J. H. Rille
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis and Treatment of Arthritis and Allied Disorders
Authors: Harry Maurice Margolis
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Osteomyelitis: Clinical Features, Therapeutic Considerations, and Unusual Aspects.
Authors: Francis A. Waldvogel, Gerald Medoff, Morton N. Swartz
Journal: Annals of Internal Medicine (1972)

are significant because essentially all of the effective and useful antistaphylococcal antibiotics (save for a few recently added analogues) were available during this period. It is also important to note that this four-year interval was well past the period of greatest prevalence and invasiveness of the staphylococci which was associated with the worldwide pandemic of infections with the virulent 80/81 and related phage types that had been dominant during much of the previous decade. Serious staphylococcal infections have decreased markedly in incidence during the period covered by this analysis. They have continued to decrease as less virulent staphylococci of new phage types and patterns with greater range of antibiotic susceptibility have superceded the multiresistant 80/81 types. Gram-negative bacilli have replaced staphylococci as the major
Surgical Diseases of Children. A Modern Treatise on Pediatric Surgery.
Authors: Samuel Walter Kelley
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 552: Mitochondrial KCa and Anion Channels Influence Mitochondrial Volume and Respiratory Rate: Relevance to Cardioprotection
Authors: Sonia Cortassa, Miguel A Aon, David A Brown, Agnieszka Sidor, Nicolas Sorarrain, Brian O’Rourke
Journal: Circulation (2007)

Ion channels in the mitochondrial inner membrane influence the response of the heart to ischemia and reperfusion - the opening of mitochondrial K + channels (mitoK Ca or mitoK ATP ) induce cardioprotection while the excessive activation of an inner membrane anion channel (IMAC) contributes to post-ischemic contractile and electrical dysfunction. Here we examined the effects of K Ca channel openers and inhibitors on mitochondrial volume and respiration in KCl-based medium in energized isolated guinea-pig heart mitochondria. Inhibition of IMAC with a mitochondrial benzodiazepine ligand was also assessed. Mitochondrial swelling and contraction were evoked by the sequential addition of 5mM glutamate (Glu) and 5mM malate (Mal), respectively. Both the swelling and contraction responses involved energy-dependent fluxes of K + and Cl − . The Glu-induced swelling response was suppressed by preincubation with either the K Ca channel toxin paxilline, or by the IMAC blocker 4′-chlorodiazepam (4-Cl-DZP). The K Ca opener NS1619, at concentrations &lt;10μM, initiated mitochondrial swelling responses either in the absence or presence of substrates. This effect was blocked by paxilline or charybdotoxin. Massive and irreversible swelling was induced by [NS1619] &gt;10μM. Under similar conditions, mitochondrial respiratory control (State3/State4 VO 2 ratio) was maintained at &gt;15 for [NS1619] &lt;10μM, but was strongly suppressed above 20μM due to an increase in state4- and a decrease in state3-respiration. 4-Cl-DZP did not affect respiration and only slightly increased the K 0.5 for ADP. The findings indicate that mitochondrial matrix volume is modulated by mitoK Ca channel activity under normal conditions and in the presence of K Ca channel openers, while IMAC channels underlie compensatory anion movements in response to K + flux. Physiological regulation of mitochondrial volume by ion transport is in turn linked to altered respiratory flux, with important implications for cardioprotection and recovery of mitochondrial function in the post-ischemic heart.
O020 : Magnetic resonance elastography is superior to clinical prediction models for determination of advanced fibrosis in patients with non-alcoholic fatty liver disease: A prospective study
Authors: J.Y. Cui, T. Wolfson, B. Ang, W. Haufe, C. Hernandez, E.C. Verna, C.B. Sirlin, R. Loomba
Journal: Journal of Hepatology (2015)
Diabetic Metabolism with High and Low Diets.
Authors: Elliott P. Joslin
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolic relationships among the plasma lipoproteins
Authors: Dana E. Wilson, Robert S. Lees
Journal: Journal of Clinical Investigation (1972)

The changes in other plasma lipoproteins which accompany alterations in very low density lipoproteins (VLDL) were studied in 31 normal and hyperlipidemic men and women who underwent weight reduction, carbohydrate induction, or clofibrate treatment. Plasma lipids and individual lipoprotein cholesterol concentrations were measured serially during control and treatment periods. Low density lipoprotein (LDL) protein was determined by radial immunodiffusion. Oppositely directed changes in VLDL and LDL were found with each of the three metabolic perturbations. Changes in high density lipoprotein (HDL) cholesterol generally paralleled those in LDL but were less consistent. Two patients with type III hyperlipoproteinemia failed to demonstrate reciprocal increases in LDL despite more than 40% reduction in plasma glycerides or VLDL with weight reduction or clofibrate therapy. After clofibrate therapy, LDL increased in proportion to the absolute decrease in VLDL cholesterol during treatment. LDL protein changed relatively less than did LDL cholesterol. The mechanism for the interdependency of plasma VLDL and LDL concentrations over the long term is not known and may be the result of altered rates of interconversion of these lipoproteins, or to feedback inhibition by VLDL of LDL production and release.
Outcry From the Inferno: Atomic Bomb Tanka Anthology
Authors: Jiro Nakano
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemopoietic Stem Cells In Polycythemia Vera and Essential Thrombocythemia Have Increased TNF-Alpha That Decreases After Pegylated Interferon-a Therapy, But Not Hydroxyurea, and Correlates With Suppression Of PV and ET Clones
Authors: Sabina Swierczek, Mohamed E Salama, Katherine King, Andrew Wilson, Sheryl Tripp, Sherrie L. Perkins, Margaret A. Goodell, Josef T. Prchal
Journal: Blood (2013)
Influence of age and health status on oncologists’ and geratricians’ adjuvant treatment recommendations for older adults with breast cancer
Authors: A. Hurria, F. L. Wong, D. Villaluna, S. Bhatia, C. T. Chung, J. Mortimer, A. Naeim
Journal: Journal of Clinical Oncology (2008)

9643 Background: To understand the impact of age and health status on adjuvant treatment (tx) recommendations for older patients (pts) with breast cancer (BC) from the perspective of medical oncologists (oncologists) and primary care doctors with geriatric expertise (geriatricians). Methods: 150 oncologists and 155 geriatricians participated in an online survey consisting of case scenarios of pts of varying ages (70, 75, 80, 85) and health status (good, average, poor) with a T2(4 cm) N2(4+ LN) ER(+), Her2neu (−) BC. The effect of pt age and health status on whether or not to treat pts were examined between oncologist and geriatrician, and their effects on type of tx recommendations among oncologists were examined. Results: Oncologists and geriatricians were less likely to recommend adjuvant tx as the pt’s age increased or health status declined (p < 0.0001). Among oncologists, the majority recommended anthracycline chemo/endocrine tx for a 70 or 75 yo pt in good health and endocrine tx alone for an 80 or 85 yo pt in poor health. The consensus among oncologists decreased for an 80yo in good health (39% recommend endocrine tx alone, 32% non-anthracycline chemo/endocrine tx, and 28% anthracycline chemo/endocrine tx) and 70yo in poor health (36% recommend endocrine tx alone, 29% non-anthracycline chemo/endocrine tx, and 34% anthracycline chemo/endocrine tx). Geriatricians were more likely than oncologists to recommend no adjuvant tx for pts age 80 and 85 (P<0.01) or those with average or poor health (P<0.01). Conclusions: Age and health status influence oncologists’ and geriatricians’ adjuvant tx recommendations. Evidence based guidelines for BC tx in older adults taking into account age and health status are needed. Geriatricians and Oncologists Tx Recommendations Health Age Geriatricians: No Treatment (%) Oncologists: No Treatment (%) Oncologists: Endocrine Tx Alone (%) Oncologists: NonAnthracyline + Endocrine Tx (%) Oncologists: Anthracycline + Endocrine Tx (%) Good 70 0 0 3 12 85 75 1 0 12 19 69 80 3 1 39 32 28 85 13 3 69 18 10 Average 70 1 0 9 21 70 75 1 0 23 32 46 80 8 0 58 27 15 85 19 5 78 12 5 Poor 70 0 1 36 29 34 75 3 2 45 34 19 80 10 4 75 16 5 85 23 9 80 9 2 Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Genentech, Pfizer Genentech, Pfizer
Abstract 5146: Pre-diabetes is Associated With Masked Hypertension
Authors: Joji Ishikawa, Joseph E Schwartz, Thomas G Pickering
Journal: Circulation (2009)

Background: Masked hypertension, a condition where awake ambulatory blood pressure (BP) is elevated (≥135/85 mmHg) while office BP is within the normal range (&lt;140/90 mmHg), is associated with an increased risk of cardiovascular events; however, mechanisms causing masked hypertension remain unclear. We evaluated whether increased glucose within the non-diabetic range (fasting glucose &lt;126 mg/dl) and/or presence of pre-diabetes (fasting glucose 100 –125 mg/dl) is associated with masked hypertension. Methods: We performed office BP measurements (3 readings/visit, at 3 visits), a single 24-hr ambulatory BP (ABP) monitoring and a fasting blood glucose test in 475 healthy, employed volunteers who did not have either office hypertension or diabetes. Results: The average age was 44.7±11.1 years (male; 37.5%). The subjects with masked hypertension (N=76) were older (47.5±8.9 vs. 44.2±10.2 years, P=0.009), more likely to be male (53.9 vs. 34.3%, P=0.001) and pre-diabetic (32.9 vs. 11.8 %, P&lt;0.001); they had higher fasting glucose (94±12 vs. 88±11 mg/dl, P&lt;0.001), body mass index (29.0±5.7 vs. 27.1±5.2 kg/m 2 , P=0.004), serum creatinine (0.87±0.15 vs. 0.82±0.15 mg/dl, P=0.009), office SBP (123±8 vs. 112±9 mmHg, P&lt;0.001) and office DBP (81±5 vs. 73±7 mmHg, P&lt;0.001) than those with normal ABP (&lt;135/85 mmHg). In a logistic regression analysis, fasting glucose level was significantly associated with masked hypertension [odds ratio (OR) per 10 mg/dl, 1.35, 95% confidence interval (CI) 1.01–1.80, P=0.044], controlling for the confounding factors. In a parallel analysis, presence of pre-diabetes was also associated with masked hypertension (OR=2.68, 95%CI 1.42–5.09, P=0.002). Prevalence of masked hypertension was 51.2% among those with both pre-hypertension and pre-diabetes, 34.5% among those with pre-hypertension alone, 10.3% among those with pre-diabetes alone, and 3.8% among those without either of them. Conclusion : Both pre-diabetes status and fasting glucose (measured on a continuum) in non-diabetic individuals are associated with presence of masked hypertension, suggesting that ambulatory BP monitoring can improve CV risk stratification (over and above office BP) in persons with pre-diabetes in addition to pre-hypertension.
In Reply:
Authors: S.P. Stenning, W.G. Jones, S.D. Fossa
Journal: Journal of Clinical Oncology (2005)

February 20 issue of the Journal of Clinical Oncology, in which they defined the appropriate radiation dose in the adjuvant treatment of stage I seminoma.It was a well done randomized trial, which tried to answer several important questions in the treatment of seminoma.Nearly 90% of the patients in the study received para-aortic strip only irradiation (PAS), without treatment to the pelvis.With reference to Table 3 of their article, I have several questions and comments.The recurrence pattern is very interesting to look at, even though it is for a small number, which has its limitations.Six (60%) of the 10 recurrences in the 30-Gy group were in the pelvic nodes, whereas three (27%) of 11 in the 20-Gy group were in the pelvic nodes.The locations of the pelvic nodes recurrences were not mentioned, so we could not see whether these recurrences could potentially have been prevented by the use of the dogleg (DL) field.If we accept the conclusions of the study, ie, 20 Gy is as effective as 30 Gy, and then we retrospectively look from the treatmentfield perspective, only 1/5 of the recurrences in the DLtreated patients was in the pelvic nodes, whereas for eight of 16 patients in the PAS-treated group the recurrences were in the pelvis.The difference in the abdominal recurrences in both groups is not as dramatic (DL, one of five; PAS, three of 16).That is as far as what can be dissected out from these data on such a small number of events.However, the data suggest (1) 20 Gy versus 30 Gy is about the same in preventing para-aortic recurrences; (2) the addition of pelvic radiation may reduce pelvic node recurrences (if these recurrences were in the potential DL fields).If that is the case, the patients in the 30-Gy group may actually have a lower overall recurrence rate (four nonpelvic-node recurrences) compared with the 20-Gy group (eight nonpelvic node recurrences), which in turn may change the overall results in the trial.This certainly opens up another can of worms in term of considering the need of using the DL field again for the treatment of stage I seminoma for doses like 20 Gy.I hope the authors can address my concerns.