tbuckley/cabot-search huggingface dataset:
68Ga-DOTATATE PET/CT Detected Bone Metastasis Earlier Than 68Ga-FAPI PET/CT and 99mTc-MDP Bone Scintigraphy in a Patient With Nasopharyngeal Carcinoma
Authors: Jieling Zheng, Hongxu Zhu, Zezhong Shao, Weibing Miao
Journal: Clinical Nuclear Medicine (2024)

Abstract A 53-year-old man with newly diagnosed nasopharyngeal carcinoma (NPC) underwent 99m Tc-MDP bone scintigraphy for the potential bone metastases, and paired 68 Ga-DOTATATE and 68 Ga-FAPI PET/CT for initial staging. 68 Ga-DOTATATE PET/CT identified 2 abnormal foci with increased tracer uptake in the cervical vertebra and the ilium, whereas 68 Ga-FAPI PET/CT and bone scan detected only the ilium lesion. A subsequent biopsy confirmed NPC metastasis in the ilium. Furthermore, baseline and follow-up bone scintigraphy revealed that the positive lesion in the cervical vertebra, as indicated in 68 Ga-DOTATATE PET/CT, was also a bone metastasis. This case highlighted the potential superiority of 68 Ga-DOTATATE in NPC.
Baseline and on Treatment Biodistribution Variability of 18F-FLT Uptake in Patients With Advanced Melanoma: Brief Communication
Authors: Bernies van der Hiel, Else A. Aalbersberg, Alfons J.M. van den Eertwegh, Jitha Fischer, Ronald Boellaard, Filip Y.F.L. de Vos, Marye J. Boers-Sonderen, Marcel P.M. Stokkel, Linda J. de Wit- van der Veen, John B.A.G. Haanen
Journal: Clinical Nuclear Medicine (2024)

Purpose This prospective study evaluates the biodistribution of 18 F-FLT PET in patients with advanced melanoma before and after treatment with BRAF/MEK inhibitors. Patients and Methods Eighteen BRAF-positive unresectable stage IIIc or IV melanoma patients referred for 18 F-FLT PET/CT before (BL) and during (D14) BRAF/MEK inhibition were included. 18 F-FLT accumulation in the liver, bone marrow, blood, and muscle was quantified. Results Baseline interpatient 18 F-FLT uptake had a coefficient-of-variation between 17.5% and 21.5%. During treatment, liver uptake increased (SUV meanBL = 4.86 ± 0.98, SUV meanD14 = 6.31 ± 1.36, P &lt; 0.001) and bone marrow uptake decreased (SUV meanBL = 7.67 ± 1.65, SUV meanD14 = 6.78 ± 1.19, P &lt; 0.025). Both changes were unrelated to baseline metabolic tumor volume or tumor response. Conclusions To assess 18 F-FLT PET, both liver and bone marrow uptake may be used as normal tissue references at baseline, but 18 F-FLT biodistribution significantly changes in longitudinal response studies when treated with BRAF/MEK inhibitors.
Multifunctional Biomimetic Liposomes with Improved Tumor‐Targeting for TNBC Treatment by Combination of Chemotherapy, Anti‐Angiogenesis and Immunotherapy
Authors: Jinshuai Lan, Lixia Chen, Zhe Li, Li Liu, Ruifeng Zeng, Yitian He, Yi Shen, Tong Zhang, Yue Ding
Journal: Advanced Healthcare Materials (2024)

Triple negative breast cancer (TNBC) featuring high relapses and metastasis shows limited clinical therapeutic efficiency with chemotherapy for the extremely complex tumor microenvironment, especially angiogenesis and immunosuppression. Combination of antiangiogenesis and immunotherapy holds promise for effective inhibition of tumor proliferation and invasion, while it remains challenging for specific targeting drug delivery to tumors and metastatic lesions. Here, a multifunctional biomimetic liposome loading Gambogic acid (G/R-MLP) is developed using Ginsenoside Rg3 (Rg3) to substitute cholesterol and cancer cell membrane coating, which is designed to increase long-circulating action by a low immunogenicity and specifically deliver gambogic acid (GA) to tumor site and metastatic lesions by homologous targeting and glucose transporter targeting. After G/R-MLP accumulates in the primary tumors and metastatic nodules, it synergistically enhances the antitumor efficacy of GA, effectively suppressing the tumor growth and lung metastasis by killing tumor cells, inhibiting tumor cell migration and invasion, achieving antiangiogenesis and improving the antitumor immunity. All in all, the strategy combining chemotherapy, antiangiogenesis, and immunotherapy improves therapeutic efficiency and prolonged survival, providing a new perspective for the clinical treatment of TNBC.
Oral Administration Properties Evaluation of Three Milk‐derived Extracellular Vesicles Based on Ultracentrifugation Extraction Methods
Authors: Bozhang Xia, Runjing Hu, Junge Chen, Shaobo Shan, Fengfei Xu, Gang Zhang, Ziran Zhou, Yubo Fan, Zhongbo Hu, Xing‐Jie Liang
Journal: Advanced Healthcare Materials (2024)

Abstract Milk‐derived extracellular vesicles (M‐EVs) are low‐cost, can be prepared in large quantities, and can cross the gastrointestinal barrier for oral administration. However, the composition of milk is complex, and M‐EVs obtained by different extraction methods may affect their oral delivery. Based on this, a new method for extracting M‐EVs based on cryogenic freezing treatment (Cryo‐M‐EVs) is proposed and compared with the previously reported acetic acid treatment (Acid‐M‐EVs) method and the conventional ultracentrifugation method (Ulltr‐M‐EVs). The new method simplifies the pretreatment step and achieves 25‐fold and twofold higher yields than Acid‐M‐EVs and Ulltr‐M‐EVs. And it is interesting to note that Cryo‐M‐EVs and Acid‐M‐EVs have higher cellular uptake efficiency, and Cryo‐M‐EVs present the best transepithelial transport effect. After oral administration of the three M‐EVs extracted by three methods in mice, Cryo‐M‐EVs effectively successfully cross the gastrointestinal barrier and achieve hepatic accumulation, whereas Acid‐M‐EVs and Ultr‐M‐EVs mostly reside in the intestine. The M‐EVs obtained by the three extraction methods show a favorable safety profile at the cellular as well as animal level. Therefore, when M‐EVs obtained by different extraction methods are used for oral drug delivery, their accumulation properties at different sites can be utilized to better deal with different diseases.
SEA Anemone‐inspired Conducting Polymer Sensing Platform for Integrated Detection of Tumor Protein Marker and Circulating Tumor Cell
Authors: Jialuo Ai, Yixuan Huang, Zhaoyi Yin, Yingshan Deng, Ling Yan, Jingwen Liao, Guoyan Liang, Chong Chen, Yunbing Chang, Cairong Xiao, Jiale Zhou, Zurong Zhu, Chengli Liu, Zhuo Jiang, Chengyun Ning, Zhengao Wang
Journal: Advanced Healthcare Materials (2024)

Combining the detection of tumor protein markers with the capture of circulating tumor cells (CTCs) represents an ultra-promising approach for early tumor detection. However, current methodologies have not yet achieved the necessary low detection limits and efficient capture. Here, a novel polypyrrole nanotentacles sensing platform featuring anemone-like structures capable of simultaneously detecting protein biomarkers and capturing CTCs is introduced. The incorporation of nanotentacles significantly enhances the electrode surface area, providing abundant active sites for antibody binding. This enhancement allows detecting nucleus matrix protein22 and bladder tumor antigen with 2.39 and 3.12 pg mL
Dexmedetomidine use during orthotopic liver transplantation surgery on early allograft dysfunction: A randomized controlled trial
Authors: Liqun Yang, Ling Zhu, Bo Qi, Yin Zhang, Chenlu Ni, Yijue Zhang, Xiao Shi, Qiang Xia, Joe Masters, Daqing Ma, Weifeng Yu
Journal: International Journal of Surgery (2024)

Background: Previous studies have shown a protective effect of dexmedetomidine use in kidney transplantation. In contrast, it is not known whether intraoperative administration of dexmedetomidine can reduce early allograft dysfunction (EAD) incidence following liver transplantation. Objective: To investigate the effect of dexmedetomidine use during surgery on EAD following orthotopic liver transplantation (OLT). Study Design: This is a single-center, double-blinded, placebo-controlled randomized clinical trial. Three hundred thirty adult patients undergoing OLT were enrolled from 14th January 2019 to 22nd May 2022. Patients received dexmedetomidine or normal saline during surgery. One year follow-ups were recorded. Methods: Patients were randomized to two groups receiving either dexmedetomidine or normal saline intraoperatively. For patients in the dexmedetomidine group, a loading dose (1 μg/kg over 10 min) of dexmedetomidine was given after induction of anesthesia followed by a continuous infusion (0.5 μg/kg /h) until the end of surgery. For patients in the normal saline group, an equal volume loading dose of 0.9% saline was given after the induction of anesthesia followed by an equal volume continuous infusion until the end of surgery. The primary outcome was EAD. Secondary outcomes included primary graft nonfunction, acute kidney injury, and acute lung injury/acute respiratory distress syndrome. Results: Of 330 patients included in the intention-to-treat analysis, 165 were in the dexmedetomidine group [mean (SD) age, 49 (10) years; 117 (70.9%) men], and 165 were in the normal saline group [mean SD age, 49 (9) years; 118 (74%) men]. 39 (24.4%) patients in the dexmedetomidine group and 31 (19.4%) in normal saline group developed EAD and the difference was statistically insignificant ( P =0.28). Secondary outcomes including primary graft nonfunction and acute kidney injury was similar between the two groups. Conclusion: Intraoperative administration of dexmedetomidine did not reduce EAD rate after OLT.
Letter to editor:Identification and validation of the surface proteins FIBG, PDGF-β, and TGF-β on serum extracellular vesicles for non-invasive detection of colorectal cancer: experimental study (Int J Surg. 2024 Mar 3.)
Authors: Yongquan Gao, Yuhang Liu, Guoshuai Liu, Yanfei Yang
Journal: International Journal of Surgery (2024)

Gao, Yongquan MD; Liu, Yuhang MD; Liu, Guoshuail MD; Yang, Yanfei PhD Author Information
A commentary on “Local resection for solid pseudopapillary neoplasms of the pancreas shows improved postoperative gastrointestinal function and reduced mental stress: a multiquestionnaire survey from a large cohort”
Authors: Tingtong Lin, Xiaoqi Zhang, Jiehao Xiao, Dandan Li
Journal: International Journal of Surgery (2024)

aThe Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, 730000, People's Republic of China bThe Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, 730000, People's Republic of China cThe Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu Province, 730000, People's Republic of China Tingtong Lin and Xiaoqi Zhang: These authors contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: The Second Department of General Surgery, The First Hospital of Lanzhou University, No.1 Road, Chengguan District, Lanzhou City, Gansu Province, People's Republic of China, 730000. E-mail address: [email protected] (D. Li). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Prognostic stratification of patients with pT4bN0M0 colorectal cancer following multivisceral resection: a multi-institutional case series analysis
Authors: Jichuan Quan, Kai Zuo, Guoli Li, Junguang Liu, Shiwen Mei, Gang Hu, Wenlong Qiu, Meng Zhuang, Ling Meng, Xishan Wang, Hu Chang, Jianqiang Tang
Journal: International Journal of Surgery (2024)

Background: Colorectal cancer (CRC) patients with stage pT4b are a complex group as they show differences in tumor-infiltrated organs. Patients with the same stage often exhibit differences in prognosis after multivisceral resection (MVR). Thus far, some important prognostic factors have not been thoroughly investigated. Here, we identified the prognostic factors influencing CRC patients at the pT4bN0M0 stage to stratify the prognostic differences among patients. Materials and methods: A retrospective analysis was conducted on patients diagnosed with locally advanced CRC and who underwent MVR at three medical institutions from January 2010 to December 2021. The prognostic factors affecting the survival of CRC patients at pT4bN0M0 stage were identified by multivariate Cox proportional hazard models. We then classified the prognosis into different grades on the basis of these independent prognostic factors. Results: We enrolled 690 patients with locally advanced CRC who underwent MVR; of these, 172 patients with pT4bN0M0 were finally included. Patients with digestive system [overall survival (OS): hazard ratio (HR)=0.441; 95% confidence interval (CI)=0.217–0.900; P =0.024; disease-free survival (DFS): HR=0.416; 95% CI=0.218–0.796; P =0.008) or genitourinary system invasion (OS: HR=0.405; 95% CI=0.193–0.851; P =0.017; DFS: HR=0.505; 95% CI=0.267–0.954; P =0.035) exhibited significantly better OS and DFS as compared to those with gynecological system invasion, while the OS and DFS were similar between the digestive system and genitourinary system invasion groups (OS: HR=0.941; 95% CI=0.434–2.042; P =0.878; DFS: HR=1.211; 95% CI=0.611–2.403; P =0.583). Multivariate analysis showed that age (OS: HR=2.121; 95% CI=1.157–3.886; P =0.015; DFS: HR=1.869; 95% CI=1.116–3.131; P =0.017) and type of organs invaded by CRC (OS: HR=3.107; 95% CI=1.121–8.609; P =0.029; DFS: HR=2.827; 95% CI=1.142–6.997; P =0.025) were the independent prognostic factors that influenced the OS and DFS of CRC patients with pT4bN0M0 disease. The OS and DFS of patients showing invasion of the gynecological system group were significantly worse ( P =0.004 and P =0.003, respectively) than those of patients with invasion of the nongynecological system group. On the basis of the above-mentioned two independent prognostic factors, patients were assigned to high-risk, medium-risk, and low-risk groups. Subgroup analysis showed that the OS and DFS of the medium-risk and high-risk groups were significantly worse ( P =0.001 and P =0.001, respectively) than those of the low-risk group. Conclusion: Patients with pT4bN0M0 CRC show significant differences in their prognosis. The type of organs invaded by CRC is a valuable indicator for prognostic stratification of CRC patients with pT4bN0M0.
Clinical status and future prospects of neoadjuvant immunotherapy for localized mismatch repair-deficient cancers: a review
Authors: Jian Li
Journal: International Journal of Surgery (2024)

Frameshift mutations accumulate in cancers related to mismatch repair deficiency (dMMR), which has the potential to produce various neoantigens, representing a distinct subset of cancers that respond considerably to immunotherapy. In recent years, robust evidence has supported the first-line application of immunotherapy for patients with metastatic dMMR cancers, which provoked extensive investigations of the feasibility and efficacy of immunotherapy in up-front settings, including neoadjuvant therapy. Several completed trials with small sample sizes suggested that neoadjuvant immunotherapy can achieve an impressively high complete response rate, for the first time offering the potential of systemic therapy to cure cancer without the need for surgical resection. However, a difficult dilemma emerges: clinicians are now facing a selection between the standard of care with good evidence for proficient MMR but suboptimal for dMMR cancers and the emerging immunotherapy with promising results but only based on a limited number of patients with shorter duration of follow-up. This review aims to provide a comprehensive summary of the biological rationale and clinical status of neoadjuvant immunotherapy in patients with dMMR cancers. Furthermore, I elaborate on particular issues that must be taken into consideration for further advancement in the field.
Pilot robotic mastectomy in Singapore (PRoMiSing I) study: first safety and feasibility prospective cohort trial in South East Asia
Authors: Chi W. Mok, Yert L. Melissa Seet, Zar C. Lin, Jun X. Jeffrey Hing, Chin M. Jaime Seah, Su-Ming Tan
Journal: International Journal of Surgery (2024)

Robotic mastectomy has been performed worldwide since 2015. The advantages of the robotic approach in nipple-sparing mastectomy have been proven with better visualization and preservation of blood supply to the nipple-areolar complex, with a lower incidence of necrosis. It also allows smaller incisions for both mastectomy and immediate breast reconstruction. To date, no centers in Singapore and Southeast Asia offer robotic mastectomy. We believe that robotic mastectomy is a feasible and safe technique that our population can utilize.
Usefulness of Fluorescence imaging with indocyanine green for evaluation of bowel perfusion in the urgency setting: a systematic review and meta-analysis
Authors: Roberta Rizzo, Carlo Vallicelli, Luca Ansaloni, Federico Coccolini, Paola Fugazzola, Massimo Sartelli, Vanni Agnoletti, Gian Luca Baiocchi, Fausto Catena
Journal: International Journal of Surgery (2024)

Fluorescence imaging with indocyanine green (ICG) has been extensively utilized to assess bowel perfusion in oncologic surgery. In the emergency setting, there are many situations in which bowel perfusion assessment is required. Large prospective studies or RCTs evaluating feasibility, safety and utility of ICG in the emergency setting are lacking. The primary aim is to assess the usefulness of ICG for evaluation of bowel perfusion in the emergency setting.
A commentary on “global, regional, and national burdens of early onset pancreatic cancer in adolescents and adults aged 15–49 years from 1990 to 2019 based on the Global Burden of Disease Study 2019: a crosssectional study”
Authors: Jie Zhu, Zhaokai Jin, Chuchu Chen
Journal: International Journal of Surgery (2024)

aZhenhai Hospital of Traditional Chinese Medicine, Ningbo, Zhejiang, China bThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Zhenhai Hospital of Traditional Chinese Medicine, No. 55 Renmin Road, Zhenhai District, Ningbo, Zhejiang, 315200, China. E-mail address: [email protected] (C. Chen). This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0/
Maturation of Human iPSC‐derived Cardiac Microfiber with Electrical Stimulation Device
Authors: Akari Masuda, Yuta Kurashina, Hidenori Tani, Yusuke Soma, Jumpei Muramatsu, Shun Itai, Shugo Tohyama, Hiroaki Onoe
Journal: Advanced Healthcare Materials (2024)

Abstract Here an electrical stimulation system is described for maturing microfiber‐shaped cardiac tissue (cardiac microfibers, CMFs). The system enables stable culturing of CMFs with electrical stimulation by placing the tissue between electrodes. The electrical stimulation device provides an electric field covering whole CMFs within the stimulation area and can control the beating of the cardiac microfibers. In addition, CMFs under electrical stimulation with different frequencies are examined to evaluate the maturation levels by their sarcomere lengths, electrophysiological characteristics, and gene expression. Sarcomere elongation (14% increase compared to control) is observed at day 10, and a significant upregulation of electrodynamic properties such as gap junction protein alpha 1 ( GJA1 ) and potassium inwardly rectifying channel subfamily J member 2 ( KCNJ2 ) (maximum fourfold increase compared to control) is observed at day 30. These results suggest that electrically stimulated cultures can accelerate the maturation of microfiber‐shaped cardiac tissues compared to those without electrical stimulation. This model will contribute to the pathological research of unexplained cardiac diseases and pharmacologic testing by stably constructing matured CMFs.
A commentary on ‘a bibliometric analysis of gastric cancer liver metastases: advances in mechanisms of occurrence and treatment options’
Authors: Yanlong Shi, Yizhu Wang, Kaiyi Niu, Yewei Zhang
Journal: International Journal of Surgery (2024)

Hepatopancreatobiliary Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210003, China Yanlong Shi, Yizhu Wang and Kaiyi Niu contributed equally to this work and shared the first authorship. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: NO.121, Jiangjiayuan, Nanjing, Jiangsu Province, 210003, China. Phone number: +8615555190939. E-mail address: [email protected] (Y. Zhang). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Benefit of neoadjuvant immunotherapy plus chemotherapy in locally advanced esophageal squamous cell carcinoma: Trial sequential analysis
Authors: I-Wen Chen, Ting-Sian Yu, Kuo-Chuan Hung
Journal: International Journal of Surgery (2024)

aDepartment of Anesthesiology, Chi Mei Medical Center, Liouying, Tainan city, Taiwan bDepartment of Anesthesiology, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan cDepartment of Anesthesiology, Chi Mei Medical Center, Tainan city, Taiwan Short title: NICT for esophageal squamous cell carcinoma. Note: The affiliations for I-Wen Chen (affiliation 1) and Kuo-Chuan Hung (affiliation 3) represent different hospitals, despite both being under the Chi Mei Medical Center. These affiliations should not be combined or confused as they are distinct entities within different locations. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author: Department of Anesthesiology, Chi Mei Medical Center, Tainan city, Taiwan Chi Mei Medical Center, No.901, ChungHwa Road, YungKung Dist, Tainan 71004, Taiwan TEL: +886-6-281-2811 FAX: +886-6-283-3806 Email: [email protected] (K. -C. Hung). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Artificial Intelligence for Real-Time Prediction of the Histology of Colorectal Polyps by General Endoscopists
Authors: Douglas K. Rex, Indira Bhavsar-Burke, Daniel Buckles, James Burton, Amanda Cartee, Kevin Comar, Adam Edwards, Blair Fennimore, Monika Fischer, Mark Gerich, Ashley Gilmore, Shadi Hamdeh, Jeffrey Hoffman, Michael Ibach, Mollie Jackson, Toyia James-Stevenson, Tonya Kaltenbach, Jeffrey Kaplan, Saurabh Kapur, Daniel Kohm, Michael Kriss, Shanker Kundumadam, Kondal R. Kyanam Kabir Baig, Paul Menard-Katcher, Cary Kraft, James Langworthy, Bharat Misra, Eric Molloy, Juan Carlos Munoz, John Norvell, Thomas Nowak, Itegbemie Obaitan, Swati Patel, Mitesh Patel, Shajan Peter, B. Marie Reid, Nicholas Rogers, Jason Ross, James Ryan, Sashidhar Sagi, Akira Saito, Salih Samo, Fayez Sarkis, Frank I. Scott, Robert Siwiec, Shelby Sullivan, Amanda Wieland, Jianying Zhang, Alessandro Repici, Cesare Hassan, Michael F. Byrne, Amit Rastogi
Journal: Annals of Internal Medicine (2024)

Real-time prediction of histologic features of small colorectal polyps may prevent resection and/or pathologic evaluation and therefore decrease colonoscopy costs. Previous studies showed that computer-aided diagnosis (CADx) was highly accurate, though it did not outperform expert endoscopists.