tbuckley/cabot-search huggingface dataset:
Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance
Authors: Léa Montégut, Peng Liu, Liwei Zhao, María Pérez-Lanzón, Hui Chen, Misha Mao, Shuai Zhang, Lisa Derosa, Julie Le Naour, Flavia Lambertucci, Silvia Mingoia, Uxía Nogueira-Recalde, Rafael Mena-Osuna, Irene Herranz-Montoya, Nabil Djouder, Sylvain Baulande, Hui Pan, Adrien Joseph, Meriem Messaoudene, Bertrand Routy, Marine Fidelle, Tarek Ben Ahmed, Olivier Caron, Pierre Busson, David Boulate, Mélanie Deschasaux-Tanguy, Nathalie Arnault, Jonathan G Pol, Eliane Piaggio, Mathilde Touvier, Laurence Zitvogel, Suzette Delaloge, Isabelle Martins, Guido Kroemer
Journal: Molecular Cancer (2024)
Long-Term Safety and Efficacy Evaluation of Travoprost Intracameral Implant Based on Pooled Analyses from Two Phase III Trials
Authors: I Paul Singh, John P Berdahl, Steven R Sarkisian, Lilit A Voskanyan, Robert E Ang, Long V Doan, David Applegate, Yannan Shen, L Jay Katz, Angela C Kothe, Tomas Navratil
Journal: Drugs (2024)
YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment
Authors: Zhenyun Yang, Xin Wang, Yizhen Fu, Weijie Wu, Zili Hu, Qingyang Lin, Wei Peng, Yangxun Pan, Juncheng Wang, Jinbin Chen, Dandan Hu, Zhongguo Zhou, Li Xu, Yaojun Zhang, Jiajie Hou, Minshan Chen
Journal: Molecular Cancer (2024)

Peritumoral hepatocytes are critical components of the liver cancer microenvironment, However, the role of peritumoral hepatocytes in the local tumor immune interface and the underlying molecular mechanisms have not been elucidated. YTHDF2, an RNA N
Durability of response to immune checkpoint blockade following treatment discontinuation and efficacy of rechallenge in advanced Merkel cell carcinoma
Authors: Tanya Ramadoss, Matthew Nichols, Christian Palacios, Zeynep Eroglu, Joseph Markowitz, Lilit Karapetyan, Ahmad A Tarhini, Evan J Wuthrick, Vernon K Sondak, Nikhil I Khushalani, Kenneth Y Tsai, Andrew S Brohl
Journal: Journal for ImmunoTherapy of Cancer (2024)

Advanced Merkel cell carcinoma (MCC) has a high response rate to immune checkpoint blockade (ICB) therapy, but the durability of responses once treatment is discontinued remains unclear. We therefore reviewed the long-term outcomes of advanced patients with MCC who discontinued ICB treatment after achieving favorable initial response.
Immune isolation-enabled nanoencapsulation of donor T cells: a promising strategy for mitigating GVHD and treating AML in preclinical models
Authors: Dan Mei, Ziyang Xue, Tianjing Zhang, Yining Yang, Lin Jin, Qianqian Yu, Jian Hong, Xianzheng Zhang, Jinru Ge, Li Xu, Han Wang, Ziwei Zhang, Yuchen Zhao, Yuanfang Zhai, Qianshan Tao, Zhimin Zhai, Qingsheng Li, Hongxia Li, Lingling Zhang
Journal: Journal for ImmunoTherapy of Cancer (2024)

In allogeneic-hematopoietic stem cell transplantation for acute myeloid leukemia (AML), donor T cells combat leukemia through the graft-versus-leukemia (GVL) effect, while they also pose a risk of triggering life-threatening graft-versus-host disease (GVHD) by interacting with recipient cells. The onset of GVHD hinges on the interplay between donor T cells and recipient antigen-presenting cells (APCs), sparking T-cell activation. However, effective methods to balance GVHD and GVL are lacking.
The association between prescribed oral anti-diabetic medication for type 2 diabetes mellitus and skin cancer risk: a systematic review and meta-analysis
Authors: Corey Simpson, Sophie Leducq, Zoe Venables, Zenas Z N Yiu, Lesley E Rhodes, Iskandar Idris, Sonia Gran
Journal: British Journal of Dermatology (2024)

We conducted a systematic review to determine if there is a significant association between prescribed oral anti-diabetic medication and the risk of developing skin cancer (basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC) and melanoma), in people with type 2 diabetes. Fourteen studies were included in total. The risk of bias ranged from low to moderate. Overall, no statistically significant association was identified between anti-diabetic medication use and skin cancer. There was a dose-response relationship with higher doses of metformin and rosiglitazone associated with a greater decrease in skin cancer risk than a low dose. The risk of BCC and cSCC reduced following metformin and rosiglitazone exposure compared to non-users.
Modulation of MMP9 and CXCR2/CXCL1/IL-8 axis in human abdominal aortic aneurysm tissues by ladarixin
Authors: Maria Lombardi, Lucia Spartano, Sabrina Nicolo, Vincenzo Ardita, Roberto Chiesa, Andrea Aramini, Marcello Allegretti, Domenico Baccellieri, Lidia De Filippis, Chiara Foglieni
Journal: Cardiovascular Research (2024)
Cardiovascular Disease After Hematopoietic Stem Cell Transplantation in Adults
Authors: David G Gent, Muhammad Saif, Rebecca Dobson, David J Wright
Journal: JACC CardioOncology (2024)

The use of hematopoietic cell transplantation (HCT) has expanded in the last 4 decades to include an older and more comorbid population. These patients face an increased risk of cardiovascular disease after HCT. The risk varies depending on several factors, including the type of transplant (autologous or allogeneic). Many therapies used in HCT have the potential to be cardiotoxic. Cardiovascular complications after HCT include atrial arrhythmias, heart failure, myocardial infarction, and pericardial effusions. Before HCT, patients should undergo a comprehensive cardiovascular assessment, with ongoing surveillance tailored to their individual level of cardiovascular risk. In this review, we provide an overview of cardiotoxicity after HCT and outline our approach to risk assessment and ongoing care.
Cardiac Substructure Radiation Dose and Associations With Tachyarrhythmia and Bradyarrhythmia After Lung Cancer Radiotherapy
Authors: Katelyn M Atkins, Samuel C Zhang, Christopher Kehayias, Christian Guthier, John He, Jordan O Gasho, Mina Bakhtiar, Katrina D Silos, David E Kozono, Paul C Zei, Anju Nohria, Andriana P Nikolova, Raymond H Mak
Journal: JACC CardioOncology (2024)

Arrhythmias are common following radiotherapy for non-small cell lung cancer.
Rapid loss of nutritional symbionts in an endemic Hawaiian herbivore radiation is associated with plant galling habit
Authors: Allison K Hansen, Jacob A Argondona, Sen Miao, Diana M Percy, Patrick H Degnan
Journal: Molecular Biology and Evolution (2024)

Abstract Insect herbivores frequently cospeciate with symbionts that enable them to survive on nutritionally unbalanced diets. While ancient symbiont gain and loss events have been pivotal for insect diversification and feeding niche specialization, evidence of recent events is scarce. We examine the recent loss of nutritional symbionts (in as little as 1 MY) in sap-feeding Pariaconus, an endemic Hawaiian insect genus that has undergone adaptive radiation, evolving various galling and free-living ecologies on a single host-plant species, Metrosideros polymorpha within the last ∼5 MY. Using 16S rRNA sequencing, we investigated the bacterial microbiomes of 19 Pariaconus species and identified distinct symbiont profiles associated with specific host-plant ecologies. Phylogenetic analyses and metagenomic reconstructions revealed significant differences in microbial diversity and functions among psyllids with different host-plant ecologies. Within a few millions of years, Pariaconus species convergently evolved the closed-gall habit twice. This shift to enclosed galls coincided with the loss of the Morganella-like symbiont that provides the essential amino acid arginine to free-living and open-gall sister species. After the Pariaconus lineage left Kauai and colonized younger islands, both open- and closed-gall species lost the Dickeya-like symbiont. This symbiont is crucial for synthesizing essential amino acids (phenylalanine, tyrosine, and lysine) as well as B vitamins in free-living species. The recurrent loss of these symbionts in galling species reinforces evidence that galls are nutrient sinks and, combined with the rapidity of the evolutionary timeline, highlights the dynamic role of insect–symbiont relationships during the diversification of feeding ecologies. We propose new Candidatus names for the novel Morganella-like and Dickeya-like symbionts.
Understanding risk factors for endometrial cancer in young women
Authors: Noah Charles Peeri, Kimberly A Bertrand, Renhua Na, Immaculata De Vivo, Veronica Wendy Setiawan, Venkatraman E Seshan, Laia Alemany, Yu Chen, Megan A Clarke, Tess Clendenen, Linda S Cook, Laura Costas, Luigino Dal Maso, Jo L Freudenheim, Christine M Friedenreich, Gretchen L Gierach, Marc T Goodman, Carlo La Vecchia, Fabio Levi, Marta Lopez-Querol, Lingeng Lu, Kirsten B Moysich, George Mutter, Jeffin Naduparambil, Eva Negri, Kelli O’Connell, Tracy O’Mara, Julie R Palmer, Fabio Parazzini, Kathryn Lee Penney, Stacey Petruzella, Peggy Reynolds, Fulvio Ricceri, Harvey Risch, Thomas E Rohan, Carlotta Sacerdote, Sven Sandin, Xiao-Ou Shu, Rachael Z Stolzenberg-Solomon, Penelope M Webb, Nicolas Wentzensen, Lynne R Wilkens, Wanghong Xu, Herbert Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Xingyi Guo, Loren Lipworth, Mengmeng Du
Journal: JNCI Journal of the National Cancer Institute (2024)

Abstract Background The American Cancer Society recommends physicians inform average-risk women about endometrial cancer risk on reaching menopause, but new diagnoses are rising fastest in women aged younger than 50 years. Educating these younger women about endometrial cancer risks requires knowledge of risk factors. However, endometrial cancer in young women is rare and challenging to study in single study populations. Methods We included 13 846 incident endometrial cancer patients (1639 aged younger than 50 years) and 30 569 matched control individuals from the Epidemiology of Endometrial Cancer Consortium. We used generalized linear models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for 6 risk factors and endometrial cancer risk. We created a risk score to evaluate the combined associations and population attributable fractions for these factors. Results In younger and older women, we observed positive associations with body mass index and diabetes and inverse associations with age at menarche, oral contraceptive use, and parity. Current smoking was associated with reduced risk only in women aged 50 years and older (Phet &amp;lt; .01). Body mass index was the strongest risk factor (OR≥35 vs&amp;lt;25 kg/m2 = 5.57, 95% CI = 4.33 to 7.16, for ages younger than 50 years; OR≥35 vs&amp;lt;25 kg/m2 = 4.68, 95% CI = 4.30 to 5.09, for ages 50 years and older; Phet = .14). Possessing at least 4 risk factors was associated with approximately ninefold increased risk in women aged younger than 50 years and approximately fourfold increased risk in women aged 50 years and older (Phet &amp;lt; .01). Together, 59.1% of endometrial cancer in women aged younger than 50 years and 55.6% in women aged 50 years and older were attributable to these factors. Conclusions Our data confirm younger and older women share common endometrial cancer risk factors. Early educational efforts centered on these factors may help mitigate the rising endometrial cancer burden in young women.
Failure in a population: Tauopathy disrupts homeostatic set-points in emergent dynamics despite stability in the constituent neurons
Authors: James N McGregor, Clayton A Farris, Sahara Ensley, Aidan Schneider, Leandro J Fosque, Chao Wang, Elizabeth I Tilden, Yuqi Liu, Jianhong Tu, Halla Elmore, Keenan D Ronayne, Ralf Wessel, Eva L Dyer, Kiran Bhaskaran-Nair, David M Holtzman, Keith B Hengen
Journal: Neuron (2024)
Decoupling the Association of Dupilumab with Cutaneous T-Cell Lymphoma Reply to “Dupilumab therapy for atopic dermatitis is associated with increased risk of cutaneous T cell lymphoma: A retrospective cohort study.”
Authors: Zachary J K Neubauer, Patrick M Brunner, Larisa J Geskin, Emma Guttman, Shari R Lipner
Journal: Journal of the American Academy of Dermatology (2024)
Harnessing Nature’s Ingenuity to Engineer Butterfly-Wing-Inspired Photoactive Nanofiber Patches for Advanced Postoperative Tumor Treatment
Authors: Hao Zheng, Kerong Chen, Yitong Dun, Yurui Xu, Anwei Zhou, Haixiong Ge, Youwen Yang, Xinghai Ning
Journal: Biomaterials (2024)
Assessment of liver graft quality during hypothermic oxygenated perfusion: the first international validation study
Authors: Jahnina Eden, Adam M Thorne, Silke B Bodewes, Damiano Patrono, Dorotea Roggio, Eva Breuer, Caterina Lonati, Daniele Dondossola, Guergana Panayotova, Amanda P C S Boteon, Daniel Walsh, Mauricio Flores Carvalho, Ivo J Schurink, Fariha Ansari, Dagmar Kollmann, Giuliana Germinario, Elisabeth Alexis Rivas Garrido, Julio Benitez, Rolando Rebolledo, Matteo Cescon, Matteo Ravaioli, Gabriela A Berlakovich, Jeroen De Jonge, Deniz Uluk, Isabella Lurje, Georg Lurje, Yuri L Boteon, James V Guarrera, Renato Romagnoli, Alexander Galkin, David Meierhofer, Robert J Porte, Pierre Alain Clavien, Andrea Schlegel, Vincent E de Meijer, Philipp Dutkowski
Journal: Journal of Hepatology (2024)
Impact of time period and birth cohort on the trend of advanced neoplasm prevalence in the 40–49 average-risk screening population
Authors: Hsu-Hua Tseng, Chiu-Wen Su, Wen-Chen Chang, Wei-Yuan Chang, Wen-Feng Hsu, Li-Chun Chang, Ming-Shiang Wu, Han-Mo Chiu
Journal: Clinical Gastroenterology and Hepatology (2024)
A CD25×TIGIT bispecific antibody induces anti-tumor activity through selective intratumoral Treg cell depletion
Authors: Xin Wei, Linlin Zhao, Fang Yang, Yajing Yang, Huixiang Zhang, Kaixin Du, Xinxin Tian, Ruihua Fan, Guangxu Si, Kailun Wang, Yulu Li, Zhizhong Wei, Miaomiao He, Jianhua Sui
Journal: Molecular Therapy (2024)
Collagen hydrogel-driven pyroptosis suppression and combined microfracture technique delay osteoarthritis progression
Authors: Jinzhi Meng, Jinfeng Lu, Cancai Jiang, Lingchuan Deng, Meimei Xiao, Junfei Feng, Tianyu Ren, Qingfa Qin, Shengcong Guo, Hongtao Wang, Jun Yao, Jia Li
Journal: Biomaterials (2024)
Focal Point Technology: Controlling Treatment Depth and Pattern of Skin Injury by a Novel Highly Focused Laser
Authors: Dieter Manstein, Henry H Chan, Jayant Bhawalkar, Irina Erenburg, Hyemin Pomerantz, Jhony Escobar, Zeina Tannous, Jane Yoo, Thanh-Nga Tran, Raj Katkam, R Rox Anderson
Journal: Journal of the American Academy of Dermatology (2024)
Case study of CD19-directed chimeric antigen receptor T-cell therapy in a subject with immune-mediate necrotizing myopathy treated in the RESET-Myositis™ phase I/II trial
Authors: Jenell Volkov, Daniel Nunez, Tahseen Mozaffar, Jason Stadanlick, Mallorie Werner, Zachary Vorndran, Alexandra Ellis, Jazmean Williams, Justin Cicarelli, Quynh Lam, Thomas Furmanak, Chris Schmitt, Fatemeh Hadi-Nezhad, Daniel Thompson, Claire Miller, Courtney Little, David Chang, Samik Basu
Journal: Molecular Therapy (2024)
All that is red is not cellulitis: Retrospective application of the ALT-70 scoring system in patients diagnosed with cellulitis in the emergency department by non-dermatologists
Authors: Sweta Subhadarshani, Anastasia Tambovtseva, Taylor Griffith, Layal Antoury, Cristobal Cintron, Jeffery Durbin, Alan Hamza
Journal: Journal of the American Academy of Dermatology (2024)
Plasma cell disorders supress mucosal anti-bacterial immunity: another dimension of immunoparesis in plasma cell neoplasms
Authors: Sian Faustini, Y L Tracey Chan, Lilli Evans, Emily Collman, Alec Rapson, Claire Backhouse, Annabelle Emery, John P Campbell, Sally Moore, Alex Richter, Guy Pratt, Mark T Drayson, Jennifer L J Heaney
Journal: Leukemia (2024)
Sphincterotomy for biliary sphincter of Oddi disorder and idiopathic acute recurrent pancreatitis: the RESPOnD longitudinal cohort
Authors: Gregory A Coté, Badih Joseph Elmunzer, Haley Nitchie, Richard S Kwon, Field Willingham, Sachin Wani, Vladimir Kushnir, Amitabh Chak, Vikesh Singh, Georgios I Papachristou, Adam Slivka, Martin Freeman, Srinivas Gaddam, Priya Jamidar, Paul Tarnasky, Shyam Varadarajulu, Lydia D Foster, Peter Cotton
Journal: Gut (2024)

Sphincter of Oddi disorders (SOD) are contentious conditions in patients whose abdominal pain, idiopathic acute pancreatitis (iAP) might arise from pressurisation at the sphincter of Oddi. The present study aimed to measure the benefit of sphincterotomy for suspected SOD.
Circulating dimethylguanidino valeric acid, dietary factors, and risk of coronary heart disease
Authors: Yoriko Heianza, Xuan Wang, Minghao Kou, Saumya Tiwari, Jeramie D Watrous, Kathryn M Rexrode, Mona Alotaibi, Mohit Jain, Qi Sun, JoAnn E Manson, Lu Qi
Journal: Cardiovascular Research (2024)

Circulating dimethylguanidino valeric acid (DMGV) was identified as a novel metabolite related to cardiorespiratory fitness and cardiometabolic abnormalities. Circulating DMGV levels are subjective to dietary modulation; however, studies on its associations with intakes of coronary heart disease (CHD)-related foods/nutrients are limited. We investigated whether plasma DMGV was related to risk of incident CHD. We tested associations of DMGV with CHD-related dietary intakes measured by 7-day dietary records and estimated corresponding disease risk.
Recent advances in copper homeostasis-involved tumor theranostics
Authors: Xinghua Ren, Xinyi Luo, Fuchang Wang, Long Wan, Xiaofan Wang, Jinya Xiong, Mengwei Ye, Shiqiao Rui, Zhu Liu, Siling Wang, Qinfu Zhao
Journal: Asian Journal of Pharmaceutical Sciences (2024)

As the third essential trace element in the human body, copper plays a crucial role in various physiological processes, which lays the foundation for its broad applications in cancer treatments. The overview of copper, including pharmacokinetics, signaling pathways, and homeostasis dysregulation, is hereby discussed. Additionally, cuproptosis, as a newly proposed cell death mechanism associated with copper accumulation, is analyzed and further developed for efficient cancer treatment. Different forms of Cu-based nanoparticles and their advantages, as well as limiting factors, are introduced. Moreover, the unique characteristics of Cu-based nanoparticles give rise to their applications in various imaging modalities. In addition, Cu-based nanomaterials are featured by their excellent photothermal property and ROS-associated tumor-killing potential, which are widely explored in diverse cancer therapies and combined therapies. Reducing the concentration of Cu
DiPTAC: A degradation platform via directly targeting proteasome
Authors: Yutong Tu, Qian Yu, Mengna Li, Lixin Gao, Jialuo Mao, Jingkun Ma, Xiaowu Dong, Jinxin Che, Chong Zhang, Linghui Zeng, Huajian Zhu, Jiaan Shao, Jingli Hou, Liming Hu, Bingbing Wan, Jia Li, Yubo Zhou, Jiankang Zhang
Journal: Acta Pharmaceutica Sinica B (2024)
Cancer therapy resistance mediated by cancer-associated fibroblast-derived extracellular vesicles: biological mechanisms to clinical significance and implications
Authors: Zhengjun Lin, Guoqing Li, Ke Jiang, Zhihong Li, Tang Liu
Journal: Molecular Cancer (2024)

Cancer-associated fibroblasts (CAFs) are a diverse stromal cell population within the tumour microenvironment, where they play fundamental roles in cancer progression and patient prognosis. Multiple lines of evidence have identified that CAFs are critically involved in shaping the structure and function of the tumour microenvironment with numerous functions in regulating tumour behaviours, such as metastasis, invasion, and epithelial-mesenchymal transition (EMT). CAFs can interact extensively with cancer cells by producing extracellular vesicles (EVs), multiple secreted factors, and metabolites. Notably, CAF-derived EVs have been identified as critical mediators of cancer therapy resistance, and constitute novel therapy targets and biomarkers in cancer management. This review aimed to summarize the biological roles and detailed molecular mechanisms of CAF-derived EVs in mediating cancer resistance to chemotherapy, targeted therapy agents, radiotherapy, and immunotherapy. We also discussed the therapeutic potential of CAF-derived EVs as novel targets and clinical biomarkers in cancer clinical management, thereby providing a novel therapeutic strategy for enhancing cancer therapy efficacy and improving patient prognosis.
JAK2V617F impairs lymphoid differentiation in myeloproliferative neoplasms
Authors: Daniel C Choi, Nassima Messali, Narasimha Rao Uda, Ghaith Abu-Zeinah, Pouneh Kermani, Maria Mia Yabut, Heidi E L Lischer, Franco Castillo Tokumori, Katie Erdos, Thomas Lehmann, Marta Sobas, Tata Nageswara Rao, Joseph M Scandura
Journal: Leukemia (2024)
Response to “Clinico-mycological and therapeutic updates on cutaneous dermatophytic infections in the era of Trichophyton indotineae”; Focus on Griseofulvin
Authors: Avrom S Caplan, Sudha Chaturvedi, Gabrielle Todd, Michelle Sikora, Pearl O Ugwu-Dike, Vartan Pahalyants, Dolly Taiwo, Jeremy A W Gold
Journal: Journal of the American Academy of Dermatology (2024)
A phase 2 open-label study of cemiplimab in patients with advanced cutaneous squamous cell carcinoma (EMPOWER-CSCC-1): Final long-term analysis of Groups 1, 2, and 3, and primary analysis of fixed-dose treatment Group 6
Authors: Brett G M Hughes, Alexander Guminski, Samantha Bowyer, Michael R Migden, Chrysalyne D Schmults, Nikhil I Khushalani, Anne Lynn S Chang, Jean-Jacques Grob, Karl D Lewis, George Ansstas, Fiona Day, Rahul Ladwa, Brian N Stein, Eva Muñoz Couselo, Friedegund Meier, Axel Hauschild, Dirk Schadendorf, Nicole Basset-Seguin, Badri Modi, Sophie Dalac-Rat, Lara A Dunn, Lukas Flatz, Laurent Mortier, Sarah Guégan, Lucie M Heinzerling, Janice M Mehnert, Sabiha Trabelsi, Ainara Soria-Rivas, Alexander J Stratigos, Claas Ulrich, Deborah J Wong, Marie Beylot-Barry, Paolo Bossi, Cristina Bugés Sánchez, Sunandana Chandra, Caroline Robert, Jeffery S Russell, Ann W Silk, Jocelyn Booth, Suk-Young Yoo, Frank Seebach, Israel Lowy, Matthew G Fury, Danny Rischin
Journal: Journal of the American Academy of Dermatology (2024)
Survival in uveal melanoma patients is linked to genetic variation at HERC2 SNP rs12913832
Authors: Maria Chiara Gelmi, Laurien E Houtzagers, Annemijn P A Wierenga, Mieke Versluis, Bastiaan T Heijmans, Gregorius P M Luyten, Peter de Knijff, Marije Te Raa, Rick H de Leeuw, Martine J Jager
Journal: Ophthalmology (2024)
Machine learning to attribute the source of Campylobacter infections in the United States: a retrospective analysis of national surveillance data
Authors: Ben Pascoe, Georgina Futcher, Johan Pensar, Sion C Bayliss, Evangelos Mourkas, Jessica K Calland, Matthew D Hitchings, Lavin A Joseph, Charlotte G Lane, Tiffany Greenlee, Nicolas Arning, Daniel J Wilson, Keith A Jolley, Jukka Corander, Martin C J Maiden, Craig T Parker, Kerry K Cooper, Erica B Rose, Kelli Hiett, Beau B Bruce, Samuel K Sheppard
Journal: Journal of Infection (2024)
Aortic aneurysm: pathophysiology and therapeutic options
Authors: Guang Yang, Abbas Khan, Wei Liang, Zibo Xiong, Johannes Stegbauer
Journal: MedComm (2024)

Aortic aneurysm (AA) is an aortic disease with a high mortality rate, and other than surgery no effective preventive or therapeutic treatment have been developed. The renin-angiotensin system (RAS) is an important endocrine system that regulates vascular health. The ACE2/Ang-(1-7)/MasR axis can antagonize the adverse effects of the activation of the ACE/Ang II/AT1R axis on vascular dysfunction, atherosclerosis, and the development of aneurysms, thus providing an important therapeutic target for the prevention and treatment of AA. However, products targeting the Ang-(1-7)/MasR pathway still lack clinical validation. This review will outline the epidemiology of AA, including thoracic, abdominal, and thoracoabdominal AA, as well as current diagnostic and treatment strategies. Due to the highest incidence and most extensive research on abdominal AA (AAA), we will focus on AAA to explain the role of the RAS in its development, the protective function of Ang-(1-7)/MasR, and the mechanisms involved. We will also describe the roles of agonists and antagonists, suggest improvements in engineering and drug delivery, and provide evidence for Ang-(1-7)/MasR's clinical potential, discussing risks and solutions for clinical use. This study will enhance our understanding of AA and offer new possibilities and promising targets for therapeutic intervention.