THE EFFECTS OF INTRAVENOUSLY ADMINISTERED VERATRUM VIRIDE IN HYPERTENSIVE AND NORMOTENSIVE SUBJECTS
Authors: A P SHAPIRO, E B FERRIS
Journal: Annals of Internal Medicine (1952)

Article1 March 1952THE EFFECTS OF INTRAVENOUSLY ADMINISTERED VERATRUM VIRIDE IN HYPERTENSIVE AND NORMOTENSIVE SUBJECTSALVIN P. SHAPIRO, M.D., EUGENE B. FERRIS, M.D., F.A.C.P.ALVIN P. SHAPIRO, M.D.Search for more papers by this author, EUGENE B. FERRIS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-3-792 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONRecent studies by Freis and his co-workers have demonstrated that veratrum viride produces a fall in blood pressure not associated with a change in cardiac output or a significant diminution in blood flow to vital organs. The effects are generally vasodilator and may be mediated through the central nervous system.Freis2and Hite3have shown that the blood pressure can be significantly lowered in most hypertensive patients when veratrum viride is given orally in sufficient amount; however, effective dosage varies widely and must be determined by individual trial in each patient. Since the preparations employed were extracts of mixtures...Bibliography1. FreisStantonCulbertsonLitterHalperinBurnettWilkins EDJRJWJMHCHRW: The hemodynamic effects of hypotensive drugs in man. 1. Veratrum viride, J. Clin. Investigation 28: 353, 1949. CrossrefGoogle Scholar2. FreisStanton EDJR: A clinical evaluation of veratrum viride in the treatment of hypertension, Am. Heart J. 36: 723, 1948. CrossrefMedlineGoogle Scholar3. Hite WK: Hypertension and veratrum viride, Illinois M. J. 90: 336, 1946. MedlineGoogle Scholar4. WilkinsStantonFreis RWJRED: Essential hypertension; therapeutic trial of Veriloid, new extract of veratrum viride, Proc. Soc. Exper. Biol. and Med. 72: 302, 1949. CrossrefMedlineGoogle Scholar5. MeilmanKrayer EO: Clinical studies of veratrum alkaloids. 1. The action of protoveratrine and veratrine in hypertension, Circulation 1: 204, 1950. CrossrefMedlineGoogle Scholar6. BoothbySandford WA: Normal values of basal or standard metabolism, Am. J. Physiol. 90: 291, 1929. Google Scholar7. KeithWagenerBarker NMHPNW: Some different types of essential hypertension; their course and prognosis, Am. J. M. Sc. 197: 332, 1939. CrossrefGoogle Scholar8. KrayerAcheson OG: The pharmacology of the veratrum alkaloids, Physiol. Rev. 26: 383, 1946. CrossrefMedlineGoogle Scholar9. LyonsMoeNelighHooblerCampbellBerryRennick RHGKRBSWKNRIBR: The effects of blockade of the autonomic ganglia in man with tetraethylammonium chloride, Am. J. M. Sc. 213: 315, 1947. CrossrefMedlineGoogle Scholar10. ChambersBrustFerris WAAEB: Comparative studies of protoveratrine, Veratrone and Veriloid in patients with hypertension. In preparation. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALVIN P. SHAPIRO, M.D.; EUGENE B. FERRIS, M.D., F.A.C.P.Affiliations: Cincinnati, Ohio*Received for publication October 9, 1950.From the Hypertension Research Laboratory of the Department of Internal Medicine, University of Cincinnati, College of Medicine and the Cincinnati General Hospital. This study was supported in part by a grant from the American Foundation for High Blood Pressure and from the Life Insurance Medical Research Fund.†Veratrone was supplied by Parke, Davis & Company through the courtesy of Dr. E. C. Vonderheide. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVERATRUM ALKALOIDS AND OTHER DRUGS STIMULATING CHEMOREFLEXESBehandlung der benignen und malignen HypertonieHypertonieHypertonieThe Medical Management of Arterial HypertensionA COMPARATIVE STUDY OF THE EFFECTS OF VERATRUM VIRIDE AND TETRAETHYLAMMONIUM CHLORIDE IN HYPERTENSION*ALVIN P. SHAPIRO, M.D., ALBERT A. BRUST, M.D., EUGENE B. FERRIS, M.D., F.A.C.P. 1 March 1952Volume 36, Issue 3 Page: 792-806 Keywords Blood pressure Children Falls Hospital medicine Hypertension Primary hypertension Research funding Research laboratories Statistical data Vasodilators ePublished: 1 December 2008 Issue Published: 1 March 1952 PDF downloadLoading ...