tbuckley/cabot-search huggingface dataset:
P0271 : Effects of FXR agonist PX20606 on tumour formation in animal models of non-alcoholic fatty liver disease
Authors: A. Whitehead, G.L. Patman, U. Deuschle, C.P. Day, C. Kremoser, D.G. Tiniakos, Q.M. Anstee, H.L. Reeves
Journal: Journal of Hepatology (2015)
SOME PROFESSIONAL AND SOCIAL TRENDS IN AMERICAN MEDICINE
Authors: Irvin Abell
Journal: Annals of Internal Medicine (1939)

Article1 September 1939SOME PROFESSIONAL AND SOCIAL TRENDS IN AMERICAN MEDICINEIRVIN ABELL, M.D.IRVIN ABELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-3-523 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is a matter of difficulty, if the task be not wholly impossible, for the individual worker in any field of medical practice correctly to evaluate the multitudinous changes which are constantly occurring in this field of human endeavor. It is but a comparatively short time since didactic instruction compassed the training for a career in medicine and the armamentarium of the doctor consisted of a thermometer, a stethoscope, an obstetrical bag and a few instruments. The increase in medical knowledge during the present century has been so vast and the changes in social, economic and scientific aspects of modern... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisville, Kentucky*Read at the New Orleans meeting of the American College of Physicians, March 27, 1939. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1939Volume 13, Issue 3Page: 523-529KeywordsThermometers ePublished: 1 December 2008 Issue Published: 1 September 1939 PDF downloadLoading ...
Abstract 12194: The Modulatory Effects of Glucagon-Like Peptide-1 (GLP-1) on Coronary Flow Reserve During Acute Hyperglycemia in Type 2 Diabetics: A Prospective Controlled Study Using Bedside Myocardial Contrast Echocardiography
Authors: Sahar S Abdelmoneim, Brenda Kirby, Edward Mendrick, Mary E Hagan, Barbara Norby, Ananda Basu, Sharon L Mulvagh
Journal: Circulation (2013)

Background: We evaluated the effect of Glucagon-like peptide-1 (GLP-1) on Coronary Flow Reserve (CFR) in type 2 diabetes (T2D). Methods: We enrolled 29 subjects with no CAD [8 T2D and 21 controls (...
Biochemical effects of Piceatannol in human HL-60 promyelocytic leukemia cells - synergism with Ara-C
Authors: Philipp Saiko, Monika Fritzer-Szekeres, Ivo Savinc, Zsuzsanna Horvath, Astrid Bernhaus, Maria Ozsvar-Kozma, Michael Grusch, Walter Jaeger, Thomas Szekeres
Journal: Cancer Research (2006)

4740   Piceatannol (3,3′,4,5′-tetrahydroxy- trans -stilbene; PT) is a naturally occurring metabolite of Resveratrol (RV). It possesses extensive cytostatic activity, triggers apoptosis, inhibits cellular pathways associated with cell proliferation, and causes cell cycle arrest in various tumor cell lines, such as human leukemia or melanoma cell lines. Due to the presence of multiple hydroxyl groups, these compounds are excellent antioxidants and effective free radical scavengers, a fact that is responsible for the anticancer effects of stilbene derivatives. PT was indeed demonstrated to be a potent inducer of apoptosis in various tumor cells, such as colon, melanoma, lymphoma or leukemia cell lines and to inhibit tyrosine kinase activity in malignant cells. In this study, we attempted to identify additional biochemical targets of PT in human HL-60 promyelocytic leukemia cells. One of these targets is ribonucleotide reductase (RR, EC 1.17.4.1), which is the rate limiting enzyme of de novo DNA synthesis with relatively low activity in resting normal cells and significantly elevated enzyme activity in malignant tumor cells. The enzyme is therefore considered to be another excellent target for cancer chemotherapy. After incubation of cells with increasing concentrations of PT for 72 hours, an IC 50  value (50% growth inhibition in comparison with untreated control cells) of 14 μM could be observed. Incubation with 40μM PT led to significant proportions of apoptotic cells (95%) and caused an arrest in the G2-M phase while depleting cells in the S phase of the cell cycle. PT was also shown to deplete intracellular dCTP and dGTP pools, and to effectively inhibit the incorporation of  14 C-labeled cytidine into DNA, thus inhibiting RR  in situ  activity. Moreover, treatment with 40μM or 80μM PT significantly depleted all NTP pools. Employing a sequential growth inhibition assay, treatment with PT and Ara-C yielded synergistic combination indices for 8 out of 12 concentrations applied (according to the equations of Chou and Talalay). We conclude that the use of PT might become an additional option for the combination treatment of leukemia and other human malignancies. Based on our data, further studies using this agent alone or in combination with Ara-C are warranted.
METASTATIC CARCINOMA SIMULATING HYPERPARATHYROIDISM
Authors: Elmer C. Bartels, Charles B. Kimmel
Journal: Annals of Internal Medicine (1940)

Case Reports1 March 1940METASTATIC CARCINOMA SIMULATING HYPERPARATHYROIDISMELMER C. BARTELS, M.D., F.A.C.P., CHARLES B. KIMMEL, M.D.ELMER C. BARTELS, M.D., F.A.C.P.Search for more papers by this author, CHARLES B. KIMMEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-9-1747 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical syndrome of hyperparathyroidism has been established. The literature contains many articles by competent investigators giving the salient features of this disease with the requisites for diagnosis. Since surgical intervention, especially early in the disease, may result in cure it is important that physicians should bear this condition in mind, especially when bone pain or pathologic fracture, with roentgenologic findings of decalcification of the skeleton are present. An essential diagnostic feature of hyperparathyroidism is an elevation of blood calcium, usually to above 12 mg. per 100 c.c.The presence of hypercalcemia even to a marked degree does not invariably...Bibliography1. MASONWARREN RLS: Metastatic carcinoma simulating hyperparathyroidism, Am. Jr. Path., 1931, vii, 415-422. Google Scholar2. BOYD W: The pathology of internal diseases, 1935, Lea and Febiger, Philadelphia, p. 550. Google Scholar3. GUTMANTYSONGUTMAN : Quoted in: Nelson Medicine, 1932, Thomas Nelson and Company, New York, vol. iii, p. 312 T. Google Scholar4. DUCUING J: Les syndromes douloureux d'envahissement large du squelette chez les cancéreuses du sein, Presse méd., 1938, xliv, 1225-1227. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 1, 1938.From the Department of Internal Medicine, The Lahey Clinic.†Now residing in Marysville, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDifferential Diagnosis of Cystic Lesions of BoneRenal Calcification in Adults 1 March 1940Volume 13, Issue 9Page: 1747-1752KeywordsBloodBoneCalciumHypercalcemiaHyperparathyroidismSkeleton ePublished: 1 December 2008 Issue Published: 1 March 1940 PDF downloadLoading ...
Autologous Stem Cell Transplantation: Exogenous Granulocyte Colony-Stimulating Factor or Granulocyte-Macrophage Colony-Stimulating Factor Modulate the Endogenous Cytokine Levels
Authors: Ugo Testa, Robert Martucci, Giovanni Scambia, Pierluigi Benedetti Panici, Salvatore Mancuso, Antonio Camagna, G. Mastroberardino, Luca Pierelli, Giacomo Menichella, Cesare Peschle
Journal: Blood (1997)
Abstract 1724: Elevated Levels of the Atherosclerotic Lesion Metalloproteinase PAPPA Are an Independent Predictor of Cardiovascular Death or CHF in STEMI: Results from the CLARITY-TIMI 28 Biomarker Study
Authors: Marc S Sabatine, David A Morrow, Songtao Jiang, Nader Rifai, Christopher P Cannon, Robert E Gerszten
Journal: Circulation (2007)

Background : Pregnancy associated plasma proteinase A (PAPPA) is a metalloproteinase found in unstable atherosclerotic lesions. The prognostic value of PAPPA in ST-elevation myocardial infarction (STEMI) is unknown. Methods : We measured circulating PAPPA levels using an ELISA (Diagnostic Systems) in a case-cohort of 731 STEMI pts undergoing lysis in CLARITY-TIMI 28 and followed for 30 d. Multivariable Cox proportional hazards regression was used to adjust for demographics, comorbidities, infarct location, Killip class, and type of lytic. Results : The median level of PAPPA was 1.67 mIU/ml (IQR 0.18–9.89 mIU/ml). Patients with higher levels of PAPPA were more likely to be male, but tended to be less likely to have hypertension or diabetes, have an anterior MI, or present in Killip class II–IV. After multivariable adjustment, patients in the top 3 quartiles were at significantly higher risk for cardiovascular death or heart failure (Figure , left, P=0.03). PAPPA levels were not correlated with other biomarkers of death or CHF, including NT-proBNP and ST2 (r&lt;0.10 for both). In a multivariable model that adjusted for clinical covariates, all 3 biomarkers were independent predictors of CV death or CHF (Figure , right, P&lt;0.02 for each) and their addition to clinical risk factors significantly raised the c-statistic from 0.74 to 0.80 (P=0.003). Conclusion : Circulating levels of PAPPA at presentation are a significant predictor of a threefold increased risk of CV death or CHF in patients with STEMI. In a multimarker model, PAPPA, NT-proBNP, and ST2 were significant and complementary predictors of risk, and their addition to clinical risk factors significantly improved the c-statistic. Risk for CV Death or CHF
Abstract 10086: Membrane Type-1 Matrix Metalloproteinase Activity and Specific In Vivo Quantitation Using Specific Targeted Microbubble Imaging: Relation to Left Ventricular Remodeling Following Myocardial Infarction
Authors: Rupak Mukherjee, William T Rivers, Risha K Patel, Robert E Stroud, F.G. Spinale
Journal: Circulation (2010)
Goals and methods of audit should be reappraised
Authors: A. Miles, P. Bentley, A. Polychronis, N. Price, J. Grey
Journal: BMJ (1996)

Goals and methods of audit should be reappraised Pragmatic methods need to be developed EDrrOR,-We agree with R A Fulton that audit in the NHS should be urgently reappraised.'The government white paper's definition of audit has been regurgitated ad nauseam as if repetition of the words "systematic" and "critical" can imprint those characteristics on an ill conceived, badly directed audit programme that has produced little of benefit to patients and doctors.Audit was initially held to be of value in assessing medical practice against local stand-
Risk Factors for Pancreatitis Following Endoscopic Retrograde Cholangiopancreatography: A Meta-Analysis
Authors: E Masci, A Mariani, S Curioni, P A Testoni
Journal: Endoscopy (2003)

Background and Study Aim: The identification of factors which increase the risk of acute pancreatitis, the most common and most severe complication of endoscopic retrograde cholangiopancreatography (ERCP), is of considerable importance. However, in four large prospective studies, the reported incidence of identified risk factors for post-ERCP pancreatitis was found to be variable. The aim of this study was to identify the most important risk factors for post-ERCP pancreatitis. Material and Methods: We performed a meta-analysis of 15 prospective clinical studies, selected out of 52 reviewed articles, in which risk factors for pancreatitis were identified. Of the 14 risk factors identified, five were patient characteristics and nine were related to the endoscopic technique. Results: When patient-related risk factors were analysed, the relative risk for suspected sphincter of Oddi dysfunction was 4.09 (95 % CI 3.37 to 4.96; P < 0.001); for female gender, 2.23 (95 % CI 1.75 to 2.84, P < 0.001); and for previous pancreatitis, 2.46 (95 % CI 1.93 to 3.12, P < 0.001). Two endoscopy-related factors were confirmed: for precut sphincterotomy the relative risk was 2.71 (95 % CI 2.02 to 3.63, P < 0.001); for pancreatic injection the relative risk was 2.2 (95 % CI 1.6 to 3.01, P < 0.001). Conclusions: This meta-analysis provides a clear basis for planning pharmacological studies or studies of new endoscopic techniques in patients at high risk of developing post-ERCP pancreatitis. Knowing which patients are most at risk may also make it easier to decide who should be considered unsuitable for same-day discharge.
A Phase 2 Trial of Guselkumab versus Adalimumab for Plaque Psoriasis
Authors: Kenneth B. Gordon, Kristina Callis Duffin, Robert Bissonnette, Jörg C. Prinz, Yasmine Wasfi, Shu Li, Yaung-Kaung Shen, Philippe Szapary, Bruce Randazzo, Kristian Reich
Journal: New England Journal of Medicine (2015)

Little is known about the effect of specific anti-interleukin-23 therapy, as compared with established anti-tumor necrosis factor therapies, for the treatment of moderate-to-severe plaque psoriasis.In a 52-week, phase 2, dose-ranging, randomized, double-blind, placebo-controlled, active-comparator trial, we compared guselkumab (CNTO 1959), an anti-interleukin-23 monoclonal antibody, with adalimumab in patients with moderate-to-severe plaque psoriasis. A total of 293 patients were randomly assigned to receive guselkumab (5 mg at weeks 0 and 4 and every 12 weeks thereafter, 15 mg every 8 weeks, 50 mg at weeks 0 and 4 and every 12 weeks thereafter, 100 mg every 8 weeks, or 200 mg at weeks 0 and 4 and every 12 weeks thereafter) through week 40, placebo, or adalimumab (standard dosage for psoriasis). At week 16, patients in the placebo group crossed over to receive guselkumab at a dose of 100 mg every 8 weeks. The primary end point was the proportion of patients with a Physician's Global Assessment (PGA) score of 0 (indicating cleared psoriasis) or 1 (indicating minimal psoriasis) at week 16.At week 16, the proportion of patients with a PGA score of 0 or 1 was significantly higher in each guselkumab group than in the placebo group: 34% in the 5-mg group, 61% in the 15-mg group, 79% in the 50-mg group, 86% in the 100-mg group, and 83% in the 200-mg group, as compared with 7% in the placebo group (P≤0.002 for all comparisons). Moreover, the proportion was significantly higher in the 50-mg, 100-mg, and 200-mg guselkumab groups than in the adalimumab group (58%) (P<0.05 for all comparisons). At week 16, the proportion of patients with at least a 75% improvement in Psoriasis Area and Severity Index scores was significantly higher in each guselkumab group than in the placebo group (P<0.001 for all comparisons). At week 40, the proportion of patients with a PGA score of 0 or 1 remained significantly higher in the 50-mg, 100-mg, and 200-mg guselkumab groups than in the adalimumab group (71%, 77%, and 81%, respectively, vs. 49%) (P<0.05 for all comparisons). Between week 0 and week 16, infections were observed in 20% of the patients in the guselkumab groups, 12% in the adalimumab group, and 14% in the placebo group.The results of this phase 2 trial suggest that guselkumab may be an effective therapy for plaque psoriasis and that control of psoriasis can be achieved with specific anti-interleukin-23 therapy. (Funded by Janssen Research and Development; X-PLORE ClinicalTrials.gov number, NCT01483599.).
The efficacy and safety of enoxaparin once-daily given partly at home, compared with unfractionated heparin given in the hospital in the treatment of proximal deep-vein thrombosis, a Brazilian multicenter study.
Authors: E. Ramacciotti, G. R. Araujo, S. Lastoria, F. Dietrich, Francisco Humberto de Abreu Maffei, N. S. Mussi
Journal: Blood (2001)
Abstract 5525: Leptin Receptor Signaling Pathways are protective Against Atherosclerosis in a Mouse Model of Obesity and Hyperlipidemia
Authors: Wei Luo, Yuechun Shen, Kevin Wickenheiser, Miina Öhman, Martin Myers, Daniel Eitzman
Journal: Circulation (2008)

Leptin is an adipocyte-derived hormone that has been shown to exert both beneficial metabolic effects and potentially adverse vascular effects in preclinical studies. To determine the effects of leptin receptor signaling pathways on atherosclerosis in the setting of obesity and hyperlipidemia, mice were generated with deficiency of apolipoprotein E ( ApoE −/− ) and either wild-type leptin receptor expression ( Lepr +/+ ,ApoE −/− ), mutant leptin receptor expression defective in all leptin receptor signaling pathways ( Lepr db/db ,ApoE −/− ), or mutant leptin receptor with selective deficiency of leptin receptor-STAT3 signaling ( Lepr s/s ,ApoE −/− ). At 27 weeks of age, which included 7 weeks on western chow, Lepr db/db ,ApoE −/− developed increased weight (61.9 ±3.5 vs 28±2.5, p&lt;0.001), increased leptin (127.8±34 vs 24±12.5, p&lt;0.003), increased NEFAC (2.4±0.75 vs 0.65±0.11, p&lt;0.05) and more atherosclerosis (13.9±1.7 vs 4.3±0.9, p=0.001) than Lepr +/+ ,ApoE −/− mice. In contrast, despite similar obesity and hyperlipidemia to Lepr db/db ,ApoE −/− mice, the atherosclerosis in Lepr s/s ,ApoE −/− was less than Lepr db/db ,ApoE −/− mice (7.3±1 vs 13.9±1.7, p=0.003) and not significantly greater than Lepr +/+ ,ApoE −/− mice (7.3±1 vs 4.3±0.9, p=0.06 ). Hepatic steatosis and adipose inflammation were also reduced in Lepr s/s ,ApoE −/− mice compared to Lepr db/db ,ApoE −/− mice. In a mouse model of obesity and hyperlipidemia, leptin receptor signaling confers protection against hepatic steatosis, fat inflammation, and atherosclerosis. These effects are independent of leptin effects on energy balance. This research has received full or partial funding support from the American Heart Association, AHA Midwest Affiliate (Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, South Dakota &amp; Wisconsin).
Abstract P092: Sexual Self-Perception and Adjustment of Cardiac Patients: A Psychometric Analysis
Authors: Elaine E Steinke, Victoria Mosack, Twyla J Hill
Journal: Circulation (2012)

Introduction: The psychological impact of a cardiac event includes feelings of sexual inadequacy, poor sexual quality, and less sexual satisfaction. Few studies have examined sexual self-perception of cardiac patients. Aim: Validate the Sexual Self-Perceptions and Adjustment Questionnaire (SSPAQ) in cardiac patients. Methods: Mailed questionnaires sent to those previously hospitalized during a 1-year period with specific cardiac diagnoses (336 respondents). The SSPAQ was developed and significantly revised from another instrument, adding 5 items (total 30 items), rewording double barreled/redundant items, and making response sets more understandable. Subscales included sexual anxiety, depression, self-efficacy, and satisfaction. The scale-level content validity index was 0.97. Statistical analyses: correlation matrices for item representativeness of underlying factors, and construct validity with confirmatory factor analysis and with known groups, comparing sexually active to not active using t-tests. Results: After item analysis, 28 items were retained, 7 per subscale; Chronbach's alpha were &gt;0.90, indicating item appropriateness for the combined scale (0.97). Using confirmatory factor analysis, factor loadings showed items were related to the 4 latent factors. For sexual anxiety, depression, and self-efficacy, loadings were above 0.60, and sexual satisfaction had 1 loading of 0.54, but all other loadings were above 0.70, suggesting subscales were reliable and valid. Construct validity comparing sexually active to inactive showed those not active had significantly lower sexual self-perception ( Table ). Conclusions: The SSPAQ is reliable and valid for measuring sexual anxiety, sexual depression, sexual self-efficacy, and sexual satisfaction, and overall sexual perception and adjustment. The instrument may be useful in both research and clinical settings to further assess cardiac patient adaptation, allowing better assessment of this aspect of sexual quality of life. Sexual Self-Perception &amp; Adjustment Factors and Sexual Activity Factor Not Sexually Active Sexually Active T-test Mean SD Mean SD Sexual Anxiety (R=7-35) 17.71 7.52 13.81 6.04 3.45 ** Sexual Depression (R=7-35) 21.36 6.08 14.65 6.33 6.20 *** Sexual Self-Efficacy (R=7-35) 19.88 7.16 26.38 5.77 −5.42 *** Sexual Satisfaction (R=7-35) 18.37 6.18 25.84 5.87 −6.19 *** Total Sexual Self-Perception(R=28-140) 85.00 22.10 108.85 20.52 −5.12 *** ** p&lt;.01 *** p&lt;.001 Higher scores= more of subscale attribute; total=greater self-perception
The Principles of Radiation Treatment
Authors: Francis Carter Wood
Journal: Annals of Internal Medicine (1931)

Article1 January 1931The Principles of Radiation TreatmentFRANCIS CARTER WOOD, M.D.FRANCIS CARTER WOOD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-7-697 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe relation of bacteria to disease was a mystery until Pasteur and Koch developed culture media which permitted the isolation of the pathogenic from the host of contaminating organisms present in the body and allowed the study of its characteristics in pure culture and facilitated the demonstration on animals of its special qualities. So all broad advances in the understanding of the principles underlying the action of radiation will only be gained by using the same method, that of experiment. Experiment consists only in simplifying conditions of observation so that confusing elements are as far as possible eliminated. The term... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York*Presented in the Symposium on Cancer before the American College of Physicians, Feb. 13, 1930. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1931Volume 4, Issue 7Page: 697-704KeywordsBacteriaBacterial pathogensCancer treatmentTuberculosis ePublished: 1 December 2008 Issue Published: 1 January 1931 PDF downloadLoading ...
Abstract 12593: Prognostic Value of Coronary Magnetic Resonance Angiography Compared to Left Ventricular Ejection Fraction and Late Gadolinium Enhancement
Authors: Yeonyee E Yoon, Kakuya Kitagawa, Shingo Kato, Masaki Ishida, Shiro Nakamori, Hiroshi Nakajima, Masaaki Ito, Hajime Sakuma
Journal: Circulation (2012)

Background The combination of coronary MR angiography (CMRA) with cine- and late gadolinium-enhanced (LGE)-MRI provides a comprehensive assessment of coronary artery disease (CAD). However, prognos...
P0310 : FAK/EZH2 functional interaction is crucial for HCC development and progression both in vivo and in vitro
Authors: D. Gnani, S. Ceccarelli, S. Artuso, C. De Stefanis, N. Panera, A. Crudele, V. Nobili, C. Leonetti, A. Alisi
Journal: Journal of Hepatology (2015)