THE PRESSOR RESPONSE OF NORMAL AND HYPERTENSIVE HUMAN SUBJECTS TO TYRAMINE INTRODUCED INTO THE ILEUM
Authors: Kendall A. Elsom, Paul M. Glenn
Journal: Annals of Internal Medicine (1938)

Article1 December 1938THE PRESSOR RESPONSE OF NORMAL AND HYPERTENSIVE HUMAN SUBJECTS TO TYRAMINE INTRODUCED INTO THE ILEUMKENDALL A. ELSOM, M.D., PAUL M. GLENN, M.D.KENDALL A. ELSOM, M.D.Search for more papers by this author, PAUL M. GLENN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-6-838 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe recent experiments of Goldblatt and his collaborators have shown that hypertension follows the production of renal ischemia in the dog. The facts that its development is entirely independent of the renal1or sympathetic nerves2and that its maintenance depends on the presence in the body of ischemic renal tissue3suggest that the hypertension so produced is due to a circulating pressor substance. This view is strengthened by the demonstration that kidneys of animals rendered hypertensive by experimental renal ischemia yield on extraction pressor substances in greater amount than do normal kidneys.4, 5These observations have stimulated the search both...Bibliography1. PAGE IH: The relationship of the extrinsic renal nerves to the origin of experimental hypertension, Am. Jr. Physiol., 1935, cxii, 166-171. CrossrefGoogle Scholar2. FREEMANPAGE NEIH: Hypertension produced by constriction of renal artery in sympathectomized dogs, Am. Heart Jr., 1937, xiv, 405-414. CrossrefGoogle Scholar3. GOLDBLATT H: Studies on experimental hypertension, ANN. INT. MED., 1937, xi, 69-103. LinkGoogle Scholar4. HARRISONBLALOCKMASONWILLIAMS TRAMFJR: Relation of kidneys to blood pressure, Arch. Int. Med., 1937, lx, 1058-1068. CrossrefGoogle Scholar5. PRINTZMETALFRIEDMAN MB: Pressor effects of kidney extracts from patients and dogs with hypertension, Proc. Soc. Exper. Biol. and Med., 1936, xxxv, 122-124. CrossrefGoogle Scholar6. MULLER P: Technique pour la détermination de la tyramine dans le liquide cephalorachidien et le serum sanguin, Compt. rend. Soc. de biol., 1936, cxxiii, 128-130. Google Scholar7. PAUNZ L: Die experimentelle Erzeugung der Nephrosclerose durch Tyramin, Ztschr. f. d. Gesam. exper. Med., 1935, xci, 424-431. Google Scholar8. HANKEKOESSLER MTKK: Studies on proteinogenous amines, Jr. Biol. Chem., 1924, lix, 835-853. CrossrefGoogle Scholar9. MILLERABBOTT TGWO: Intestinal intubation, a practical technique, Am. Jr. Med. Sci., 1934, clxxxvii, 595-599. CrossrefGoogle Scholar10. EWINSLAIDLAW AJPP: The fate of parahydroxyphenylethylamine in the organism, Jr. Physiol., 1910-1911, xli, 78-87. CrossrefGoogle Scholar11. HINESBROWN EAGE: A standard test for measuring the variability of blood pressure: its significance as an index of the prehypertensive state, ANN. INT. MED., 1933-1934, vii, 209-217. Google Scholar12. PAL J: Gefässkrisen, 1905, S. Hirzel, Leipsig. Google Scholar13. BARATH E: Arterial hypertension and physical work, Arch. Int. Med., 1928, xlii, 297-300. CrossrefGoogle Scholar14. O'HARE JP: Vascular reactions in vascular hypertension, Am. Jr. Med. Sci., 1920, clix, 369-380. CrossrefGoogle Scholar15. RAAB W: Die Beziehung zwischen CO2-Spannung und Blutdruck bei Normalen und Hypertonickern, Ztschr. f. d. Gesam. exper. Med., 1929, lxviii, 337-370. CrossrefGoogle Scholar16. FATHEREEBROWN TJGE: Digital arterioles of normal and hypertensive individuals; their response to intravenous administration of epinephrine as measured by cutaneous temperature, Am. Heart Jr., 1937, xiii, 1-6. Google Scholar17. LANDISMONTGOMERYSPARKMAN EMHD: The effects of pressor drugs and of saline kidney extracts on blood pressure and skin temperature, Jr. Clin. Invest., 1938, xvii, 189-205. CrossrefGoogle Scholar18. PICKERING GW: The peripheral resistance in persistent arterial hypertension, Clin. Sci., 1935-1936, ii, 209-235. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 14, 1938.From the Gastro-Intestinal Section (Kinsey-Thomas Foundation) of the Medical Clinic, Hospital of the University of Pennsylvania.†Justice M. Thompson Fellow in Gastro-Enterology. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1938Volume 12, Issue 6Page: 838-844KeywordsGastroenterology and hepatologyHospitalsHypertensionIleumKidneysRenal ischemia ePublished: 1 December 2008 Issue Published: 1 December 1938 PDF downloadLoading ...