tbuckley/cabot-search huggingface dataset:
Abstract P382: Differential Distributions of Carotid-Femoral and Brachial-Ankle Pulse Wave Velocity with Age and Race: The ARIC Study
Authors: Michelle L Meyer, Hirofumi Tanaka, Natalia Gouskova, David Aguilar, Sunil K Agarwal, Gerardo Heiss
Journal: Circulation (2013)

Background: Carotid-femoral PWV (cfPWV), a well-studied measure of central arterial stiffness is associated with cardiovascular disease and mortality. Brachial-ankle PWV (baPWV) is commonly used in Asian countries as a measure of peripheral arterial stiffness. Few studies have evaluated the population distributions of cfPWV and baPWV and the degree to which they may measure the same arterial characteristics. Objectives: Characterize cfPWV and baPWV in a population of older adults by age, gender and race. Methods: We analyzed 2,403 adults (1473 females; mean age 75 years) from the population-based Atherosclerosis Risk in Communities (ARIC) study who had data on cfPWV and baPWV, after excluding 763 individuals due to arrhythmias, 165 with BMI &gt;40 kg/m2, and 300 with missing covariates of interest. Technicians used Omron VP-1000 plus system (Colin Co., Komaki, Japan) and followed a standardized protocol, to measure cfPWV and baPWV twice, and the results were averaged. The cumulative distributions of cfPWV and the right baPWV by age dichotomized at median, sex and race (African American (AA) and non-AA) were evaluated with the Kolmogorov-Smirnov test and the relationship between cfPWV and baPWV assessed by the Pearson correlation coefficient. Results: The mean (SD) cfPWV and baPWV was 1159 (303) and 1736 (319) cm/sec. The empirical distribution function of both these measures was higher (p&lt;0.001) among those 75 years and older than those younger than 75 years i.e., mean (SD) of cfPWV was 1229 (321) vs.1099 (274) cm/sec, respectively, and mean (SD) of baPWV was 1814 (328) vs. 1670 (295) cm/sec, respectively. The distribution function of cfPWV was higher among AAs (p&lt;0.001) but the distribution of baPWV was not different by race (p=0.76). The mean (SD) in cm/sec for AA participants compared to non-AA participants for cfPWV was 1232 (335) vs. 1138 (290), and baPWV was 1725 (324) vs. 1740 (317). The distributions of cfPWV and baPWV did not differ by gender, p=0.21 and p=0.23, respectively. The mean (SD) cfPWV and baPWV among males was 1174 (305) and 1728 (318), and among to females was 1150 (302) and 1742 (320) cm/sec. Correlation analysis showed that cfPWV and baPWV were positively correlated, r=0.45, (p&lt;0.001). Conclusion: The distributions of cfPWV and baPWV were similar by gender but were different by age and by race. Despite having comparable measure of peripheral vascular stiffness, African Americans showed a higher degree of central vascular stiffness compared to non-African Americans. Our findings indicate that cfPWV and baPWV are correlated measures of arterial stiffness but likely reflect different aspects of segment-specific vascular impairment and cardiovascular risk.
The Science of Quality Improvement
Authors: Pierre Durieux
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17167: Effects of Arm-Ergometry Exercise Training on Vascular Function in Patients with Severe Peripheral Arterial Disease Unable to Perform Traditional Walking Exercise Training
Authors: Ulf G Bronas, Arthur S Leon, Diane Treat-Jacobson
Journal: Circulation (2010)

We previously reported that endothelial dysfunction as assessed by brachial artery flow mediated vasodilatation (FMD) is predictive of reduced transcutaneous oxygen tension (TcPO2) in the feet of p...
Prediction of Future Overt Pulmonary Hypertension by 6-Min Walk Stress Echocardiography in Patients With Connective Tissue Disease
Authors: Kenya Kusunose, Hirotsugu Yamada, Junko Hotchi, Mika Bando, Susumu Nishio, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Jun Kishi, Masataka Sata
Journal: Journal of the American College of Cardiology (2015)
Clinical study on harvesting lymph nodes with carbon nanoparticles for advanced gastric cancer: A prospective randomized trail.
Authors: Ziyu Li, Sheng Ao, Jiafu Ji
Journal: Journal of Clinical Oncology (2015)

159 Background: There were no ideal materials nor quantizing regime for surgeons’ training on harvesting lymph nodes in advanced gastric cancer(AGC). A prospective randomized trial on Carbon Nanoparticles (CNP),a kind of lymphatic tracers, was designed to find a solution. Methods: Patients with previously untreated resectable AGC were eligible for inclusion in this study. All patients were randomly allocated to two subgroups. In experimental group, total of 1.0 mL CNP was injected into the subserosa of stomach around the tumor before gastrectomy with D2 dissection performed. On the contrary, the same procedure was performed directly without any coloring materials in control arm. Following surgery,the investigator harvested lymph nodes (LNs), counted colored LNs and measured the diameters with pathologist. Results: 30 patients were enrolled in the study. We observed no serious adverse effects related to CNP injection. The rate of stained LNs was 46.6%. The mean number of harvested LNs was larger in experimental than control group (38.33 vs. 28.27, p=0.041). Smaller diameter was recorded in experimental arm (3.32vs4.30mm,p=0.023), which might clarify the reason why the number of LNs was larger with CNP. In addition, we set up a model for predicting total number of LNs based on the data of CNP-staining LNs and metastatic LNs(MLNs), which might help the surgeons review their work of removing LNs so as to improve their surgical skills. Conclusions: CNP was a kind of safe materials and surgeons could harvest more LNs with it in AGC, which might benefit from the harvest of more smaller ones. Further study was needed to prove the model’s practicability. Clinical trial information: NCT02123407.
An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation
Authors: Tangui Le Guen, Fabien Touzot, Isabelle André-Schmutz, Chantal Lagresle-Peyrou, Benoit France, Laetitia Kermasson, Nathalie Lambert, Capucine Picard, Patrick Nitschke, Wassila Carpentier, Christine Bole-Feysot, Annick Lim, Marina Cavazzana, Isabelle Callebaut, Jean Soulier, Nada Jabado, Alain Fischer, Jean-Pierre de Villartay, Patrick Revy
Journal: Journal of Allergy and Clinical Immunology (2015)
Abstract 901: Impact of Microvascular Dysfunction on Long-Term Cardiovascular Events after Primary Coronary Intervention for Acute Myocardial Infarction in Patients Achieving TIMI Grade 3 Reperfusion
Authors: Koichi Tamita, Atsushi Yamamuro, Syuichiro Kaji, Minako Katayama, Tomoko Tani, Makoto Kinoshita, Natsuhiko Ehara, Takeshi Kitai, Takashi Yamane, Yutaka Furukawa, Takashi Akasaka
Journal: Circulation (2008)

It has been reported that even if TIMI 3 flow is achieved in epicardial coronary arteries after primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI), microvascular dysfunction results in insufficient reperfusion. Recent studies have shown that microvascular injury can be assessed from coronary flow velocity (CFV) pattern. The aim of this prospective study was to examine whether the CFV pattern predicts the long-term cardiovascular outcomes in AMI patients who achieved TIMI grade 3 reperfusion. The study population consisted of 161 consecutive patients with a first anterior AMI successfully treated with primary PCI (≤50% residual stenosis with TIMI grade 3). We examined the CFV pattern immediately after PCI using a Doppler guidewire. We defined microvascular dysfunction as a diastolic deceleration time ≤600 ms and the presence of systolic flow reversal. Patients were divided into two groups: those without microvascular dysfunction (n=126; group 1) and those with micriovascular dysfunction (n=35; group 2). We evaluated the association between the microvascular dysfunction and the long-term major adverse cardiovascular event (MACE) rates. The Kaplan-Meier survival curves showed that group 2 was poorer than group 1 in prognosis (p=0.0014). Risk-adjusted data by multivariate analysis showed that the microvascular dysfunction was the strongest predictor for long-term MACE (hazard ratio: 3.37; 95% CI, 1.59–7.15; p=0.0015). The CFV pattern immediately after PCI is an accurate predictor of the long-term cardiovascular outcomes in patients with AMI who achieved TIMI grade 3 reperfusion.
Abstract 1803: The Scimitar Syndrome: An European Multicentric Study
Authors: Vladimiro L Vida, Simone Speggiorin, Massimo A Padalino, Giovanna Boccuzzo, Giovanni Stellin
Journal: Circulation (2009)

Background: Scimitar syndrome is a rare congenital heart disease. In order to evaluate the surgical results of managing this malformation, we have embarked on a multi-centric European study involving 19 different Centres and reporting the widest so far published series in the medical literature.

Methods: From January 1997 to December 2007, 68 patients with scimitar syndrome who underwent surgical correction, were included. Primary outcomes include hospital mortality and the efficacy of repair at the follow-up.

Results: Median age was 1.32 years (IQR 0.28 –7.87). Forty-two patients (62%) presented with symptoms including upper respiratory tract infections (n=25), cardiac failure (n=24), recurrent pneumonia (n=9), and cyanosis (n=4). Surgical repair included: intra-atrial baffle technique in 38 patients (56%)(group 1), re-implantation of the “scimitar vein” onto left atrium in 21 patients (31%)(group 2). Nine patients (13%) underwent a right pneumectomy together with atrial septal defect closure (group 3). Four patients died in hospital (5.9%)(1 in group 1, 2.6% and 3 in group 3, 33%)(p=0.008). Postoperative complications were more frequently reported in group 3 (7/9, 78%)(p=0.02, group 3 vs. all) if compared to group 2 (14/21, 67%) and group 1 (14/38, 37%)(p=0.02, group 2 vs. group



1.  and related to the presence of preoperative congestive heart failure (OR=13). Median follow-up time was 4.5 year (IQR 1.6 – 8.3). Nine of 58 patients who survived the corrective procedure (15.5%) showed a stenosis of the scimitar drainage (6/37 in group 1, 16% and 3/21, 14.3% in group

2.  Four patients (7%) required a reoperation, all in group 1; three patients (5.3%) required balloon dilation/stenting for scimitar vein stenosis (2 in group 1, 6% and 1 in group 2, 4.8%).



There were 2 late deaths (3.1%) due to severe pulmonary arterial hypertension (1 in group 1, 2.7% and 1 in group 2, 4.7%).

Conclusions: Surgical repair of scimitar syndrome is safe and effective, however, a relatively high incidence of stenosis of the scimitar venous drainage is present at follow-up. The intra-atrial baffle technique carries a lower incidence of postoperative complications, but it seems to relates to a higher incidence of reoperations for scimitar vein stenosis.
Colony stimulating factor use and outcomes for breast, lung, and colorectal cancer patients in Washington State
Authors: S. D. Ramsey, S. D. Sullivan, J. Malin, D. K. Blough, L. Clarke, J. S. McCune
Journal: Journal of Clinical Oncology (2007)

6616 Background: Guidelines recommend colony stimulating factor (CSF) primary prophylaxis (PP) with chemotherapy if febrile neutropenia risk (FN) is =20%. Use of and outcomes for persons receiving CSF in clinical practice are relatively unknown. Methods: Using claims for Medicare and Medicaid enrollees linked to the Puget Sound SEER registry, breast (BCa), lung (LCa) and colorectal cancer (CRCa) patients diagnosed 2002–04 who received chemotherapy were categorized as: CSF at the start of chemotherapy (PP); other CSF; no CSF. Logistic regression was used to determine predictors of CSF PP and hospitalization for FN, controlling for cancer stage, age, sex, race, chemotherapy FN risk (from the National Comprehensive Cancer Network), radiation therapy, CSF use, health insurance, surgery =30 days of chemotherapy. Results: 364 BCa, 908 LCa, and 452 CRCa patients received chemotherapy. 43% of BCa, 30% of LCa, and 15% of CRCa patients received CSF. Only 9%, 6%, and 0.6% of patients initiated CSF as PP in the first cycle of chemotherapy. CSF use increased for all cancers, but most for BCa, (36% in 2002 to 70% in 2004); PP increased from 5% to 26%. Significant predictors (p&lt;0.05) of PP were: BCa–local vs distant stage (OR 0.2), regional vs distant (OR 0.6), chemotherapy FN risk high vs low (OR 6.7); LCa–chemotherapy FN risk high vs low (OR 8.9), intermediate vs low (OR 6.3). FN incidence was 11%, 18% and 32% for BCa, CRCa, LCa, respectively. Significant predictors of FN were: BCa–nonwhite race (OR 2.7); LCa–surgery within 30 days (OR 1.7); CRCa–regional vs. distant (OR 0.4) and chemotherapy FN risk intermediate vs. low (OR 4.2). Conclusions: CSF use has increased significantly, but often in settings where efficacy is uncertain. Cancer type, stage and chemotherapy risk of FN influenced use of primary prophylaxis. Non-chemotherapy factors also appear to influence risk for FN. No significant financial relationships to disclose.
Abstract 9908: Acute Hemodynamic Improvement During Dual Sites Pacing Study Does Not Predict the Late Hemodynamic and Functional Status by Cardiac Re-synchronization Therapy in Patients with a Right Ventricular Type Systemic Ventricle
Authors: Heima Sakaguchi, Aya Miyazaki, Tetsuya Yamamoto, Akiko Komori, Michio Matsuoka, Hideo Ohuchi
Journal: Circulation (2011)

Background: Cardiac resynchronization therapy (CRT) has shown a reduced mortality as well as functional improvements in patients with refractory heart failure. However, data on CRT in patients with congenital heart disease (CHD) are limited. Objectives: This study aims to clarify the efficacy of CRT in CHD patients with various hemodynamic settings, especially a morphology of the systemic ventricle (SV). Methods: The study population consisted of 17 CHD patients (mean 22 ± 12.7 years old) who had been treated with CRT since 2006. We divided the patients into 3 groups based on types of the hemodymamics and the type of SV, i.e., 7 patients with left ventricle SV (sLV), 6 with right ventricle SV (sRV) after a biventricular repair, and 4 with the unbalanced SV single ventricular physiology (sBV). We evaluated the acute effect of CRT on hemodynamics and SV function before the device implantation and also assessed chronic (≥ 6 months) impact of CRT on the late outcome, including plasma brain natriuretic peptide level (BNP: pg/ml) and New York Heart Association (NYHA) functional class. Results: In all patients, the SV volume (ml/m2) (139 ± 41 to 117 ± 36) and BNP (353 ± 396 to 112 ± 102) decreased (p &lt; 0.01 for both) with the improvement of NYHA functional class (2.1 ± 0.7 to 1.9 ± 0.8, p =0.04) 6 months after the CRT. Among the 3 groups, the sRV group did not show a late SV volume reduction despite the shortening of QRS width (198 ± 28 to 136 ± 19 ms, p =0.0005) and increase in SV peak dP/dt ( p =0.02) at the acute study, while the other 2 groups showed the acute and late hemodynamic improvement with the late SV volume reduction. Conclusions: The CRT improves late hemodynamic and functional status in sLV and sBV CHD patients with a dyssynchronized SV. However, an acute effect of CRT cannot guarantee the long-term benefit in sRV patients.
Abstract 12640: Prognostic Utility of Myocardial Fatty Acid Imaging in Risk Stratification for Sudden Cardiac Death in Patients with Ischemic Cardiomyopathy
Authors: Mitsumi Yamashita, Kanki Inoue, Nobuo Iguchi, Jun Umemura, Tetsuya Sumiyoshi, Hitonobu Tomoike
Journal: Circulation (2011)
Concern mounts over female genital mutilation
Authors: J Jones
Journal: BMJ (2000)

According to estimates by the WHO, up to 140 million girls and women have undergone female genital mutilation (FGM), and each year another 2 million are thought to be at risk of it. Most girls who undergo this ritual live in Africa and to a lesser extent in Asia and the Middle East. However, there has been an increasing occurrence of genital mutilations among migrants from these countries who have settled in the US, Europe, and Australia. Although some countries prohibit the practice, evidence suggests that these laws are defied. In the UK, Baroness Ruth Rendell, the prime mover behind a cross-party parliament inquiry into FGM is convinced that some health professionals are still carrying out the operation on request. To this effect, she is advocating some prosecutions under the 1985 act. Rendell is also pressing for resources to be put into education and awareness campaigns for girls and women to have an informed choice as to whether to submit to the procedure or not.
Mutations in <i>COQ2</i> in Familial and Sporadic Multiple-System Atrophy
Authors: Jun Mitsui, Takashi Matsukawa, Hiroyuki Ishiura, Yoko Fukuda, Yaeko Ichikawa, Hidetoshi Date, Budrul Ahsan, Yasuo Nakahara, Yoshio Momose, Yuji Takahashi, Atsushi Iwata, Jun Goto, Yorihiro Yamamoto, Makiko Komata, Katsuhiko Shirahige, Kenju Hara, Akiyoshi Kakita, Mitsunori Yamada, Hitoshi Takahashi, Osamu Onodera, Masatoyo Nishizawa, Hiroshi Takashima, Ryozo Kuwano, Hirohisa Watanabe, Mizuki Ito, Gen Sobue, Hiroyuki Soma, Ichiro Yabe, Hidenao Sasaki, Masashi Aoki, Kinya Ishikawa, Hidehiro Mizusawa, Kazuaki Kanai, Takamichi Hattori, Satoshi Kuwabara, Kimihito Arai, Shigeru Koyano, Yoshiyuki Kuroiwa, Kazuko Hasegawa, Tatsuhiko Yuasa, Kenichi Yasui, Kenji Nakashima, Hijiri Ito, Yuishin Izumi, Ryuji Kaji, Takeo Kato, Susumu Kusunoki, Yasushi Osaki, Masahiro Horiuchi, Tomoyoshi Kondo, Shigeo Murayama, Nobutaka Hattori, Mitsutoshi Yamamoto, Miho Murata, Wataru Satake, Tatsushi Toda, Alexandra Dürr, Alexis Brice, Alessandro Filla, Thomas Klockgether, Ullrich Wallner, Garth Nicholson, Sid Gilman, Clifford W. Shults, Caroline M. Tanner, Walter A. Kukull, Virginia M.Y. Lee, Eliezer Masliah, Phillip A. Low, Paola Sandroni, John Q. Trojanowski, Laurie Ozelius, Tatiana Foroud, Shoji Tsuji
Journal: New England Journal of Medicine (2013)

Multiple-system atrophy is an intractable neurodegenerative disease characterized by autonomic failure in addition to various combinations of parkinsonism, cerebellar ataxia, and pyramidal dysfunction. Although multiple-system atrophy is widely considered to be a nongenetic disorder, we previously identified multiplex families with this disease, which indicates the involvement of genetic components.
Abstract 275: Ammonia as a Biochemical Marker of Neurological Outcomes for Patients Treated With Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest. J-PULES-Hypo Registry
Authors: Asuka Kasai, Ken Nagao, Taketomo Soga, Masakazu Matsuzaki, Naohiro Yonemoto, Hiroyuki Yokoyama, Hiroshi Nonogi
Journal: Circulation (2010)

Background:  Excessive accumulation of ammonia induces neuronal metabolic derangements, promotes astrocyte swelling, and perturbs cerebral nitric oxide metabolism. Although studies have shown there is a correlation between increase in blood ammonia level and hepatic encephalopathy, few data are available for patients treated with therapeutic hypothermia after out-of-hospital cardiac arrest.   Methods:  We did a multicenter observational study of therapeutic hypothermia for unconscious adult patients with return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest. The J-PULSE Hypothermia committee entrusted each hospital with the timing of cooling, cooling methods, target temperature, duration, rewarming rate and measurement of blood ammonia. The primary endpoint was a favorable neurological outcome at hospital discharge.   Results:  Of the 432 unconscious adult patients who were treated with therapeutic hypothermia (32 °C to 34 °C) after ROSC, 143 whose blood ammonia level was measured on arrival at the emergency room were included. The quartiles of ammonia levels were a median of 79.5μg/dl, and 25th and 75th percentile values of 47.5μg/dl and 136.5μg/dl, respectively. A total of 82 (57.3%) of the 143 patients had favorable neurological outcomes. The ammonia level was lower among such patients than among those who had unfavorable neurological outcomes (a median, 72 μg/dl vs.110μg/dl; p=0.0002). Significant differences were seen in frequency of favorable neurological outcome among patients with the quartiles of ammonia levels (71% in the Q-1, 67% in the Q-2, 67% in the Q-3, 25% in the Q-4; p   Conclusion:  High level of ammonia on ER arrival was associated with poor neurological outcome for patients treated with therapeutic hypothermia. Ammonia provides useful predictive neurological information before or immediately after induction of hypothermia.
Abstract 14354: Cardiorenal Actions of the Designer Natriuretic Peptide, Cenderitide, in a Severe Heart Failure Model Treated With Furosemide Bolus
Authors: Elizabeth C Costello, Guido Boerrigter, Sarah Mangiafico, Alessandro Cataliotti, John C Burnett
Journal: Circulation (2011)

BACKGROUND: Diuretic therapy can provide symptomatic improvement in congestive heart failure (HF) although diuretic resistance and renal dysfunction can occur. Cenderitide (or CD-NP, “CD”), now in ...
Lineage-Specific Distribution of CALR EXON 9, JAK2V617F, MPLW515L/K, NPM1 and FLT3 Mutations in Myeloid Disorders
Authors: Bettina Burnworth, Richard Bennington, Wayne Fritschle, Phung Nguyen, Stephanie Verkamp, Bennington Angela, Collette Wentzel, Lisa Broderson, Michael R. Loken, Denise A. Wells, Barbara Katharina Zehentner
Journal: Blood (2014)
Gastric lavage poses risks to patient
Authors: J. B Robins
Journal: BMJ (1995)

Niuhuang Wan was found to contain 47 mg mercury and Zhusha Aushen 659 mg mercury (in the form of cinnabar).Arsenic and lead were also detected.When taken together as prescribed this would have resulted in a daily intake of 706 mg of cinnabar.We are concerned that the use of this amount of mercuric sulphide in long term treatment is potentially hazardous and could lead to mercury intoxication.Kew et al reported symptoms of mercury poisoning in a patient after daily exposure to 180-252 mg cinnabar for four weeks.2Cinnabar has been used for a long time in traditional medicines.The toxic effects of inorganic mercury are well recognised, but because of its insolubility it has been assumed that this compound would not be significantly absorbed from the gastrointestinal tract.However, a study by Yeon et al of the oral absorption of cinnabar in mice found a significant increase in mercury concentrations in the liver and kidney.Con- comitant use of cinnabar and drugs containing bromides, sulphates, sulphides, nitrates, and iodine may enhance its toxicity by increasing the gastrointestinal absorption.'We wish to bring the availability and use of these preparations to the attention of medical professionals and to emphasise the importance of obtaining full information on all the medications used by their patients.We are carrying out a traditional remedies surveillance project and would be interested in receiving reports of adverse reactions to herbal remedies and food supplements.