TREATMENT OF CHRONIC CONGESTIVE HEART FAILURE WITH NEOHYDRIN FOR FROM EIGHT TO 65 MONTHS
Authors: G C GRIFFITH, S P DIMITROFF, M C THORNER
Journal: Annals of Internal Medicine (1956)

Article1 July 1956TREATMENT OF CHRONIC CONGESTIVE HEART FAILURE WITH NEOHYDRIN FOR FROM EIGHT TO 65 MONTHSGEORGE C. GRIFFITH, M.D., F.A.C.P., SIM P. DIMITROFF, M.D., F.A.C.P., M. C. THORNER, M.D., F.A.C.P.GEORGE C. GRIFFITH, M.D., F.A.C.P., SIM P. DIMITROFF, M.D., F.A.C.P., M. C. THORNER, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-1-7 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe most widely studied, recently introduced oral mercurial diuretic has been chlormerodrin (3-chloromercuri-2-methoxypropylurea), registered under the name of Neohydrin.† The indications for and limitations of oral organomercurial diuretics in the treatment of chronic congestive heart failure have been reported.1Since Neohydrin is a relatively new medication, its effects after prolonged usage have received limited notice.2It is the purpose of this study to evaluate its degree of effectiveness during a period of time of from eight to 65 months. In addition, due to the widespread belief that the principal toxicity of organomercurial diuretics appears in the kidney, especial attention was...Bibliography1. DimitroffThornerGriffith SPMCGC: Mercurial diuretics: the replacement of parenteral administration by a new oral preparation in ambulatory patients with chronic congestive heart failure, Circulation 7: 381, 1953. CrossrefGoogle Scholar2. DohertyBeardSadik JEOWH: The management of congestive heart failure with an oral mercurial diuretic, Am. Pract. and Digest. Treat. 5: 749, 1954. MedlineGoogle Scholar3. Cornell Conference on Therapy: Choice of diuretic agent, New York State J. Med. 54: 2853, 1954. MedlineGoogle Scholar4. Vogl A: Diuretic therapy, 1953, Williams and Wilkins Co., Baltimore, p. 111. Google Scholar5. ScheifleyRaceSchumacherEdwards CHGAOPJE: The significance of albuminuria in congestive heart failure: a clinicopathologic study, Circulation 12: 769, 1955. Google Scholar6. KaplanZitmonSalarzMillerYehlmanKaplan BMIHMDGJSLA: Clinical experience with a new oral mercurial diuretic, 3-chloromercuri-2-methoxypropylurea (1347 Ex.), J. Lab. and Clin. Med. 42: 269, 1953. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE C. GRIFFITH, M.D., F.A.C.P.; SIM P. DIMITROFF, M.D., F.A.C.P.; M. C. THORNER, M.D., F.A.C.P.Affiliations: Los Angeles, California*Received for publication January 30, 1956.From the Department of Medicine (Cardiology), University of Southern California School of Medicine, and the Los Angeles County Hospital, Los Angeles, California.Requests for reprints should be addressed to George C. Griffith, M.D., P. O. Box 25, 1200 North State St., Los Angeles 33, California.†The Neohydrin was kindly supplied by the Lakeside Laboratories, Inc. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuecksilberhaltige DiureticaA Reversible Nephrotic Syndrome Associated with Congestive Heart Failure 1 July 1956Volume 45, Issue 1 Page: 7-13 Keywords Diuretics Edema Heart failure Hospital medicine Kidneys Longitudinal studies Toxicity ePublished: 1 December 2008 Issue Published: 1 July 1956 PDF downloadLoading ...