tbuckley/cabot-search huggingface dataset:
Abstract 8594: Rapid ST-upslope on Exercise Electrocardiogram Predicts Reduced Long Term Mortality from Coronary Heart Disease.
Authors: Christian Hodnesdal, Erik Prestgaard, Gunnar Erikssen, Knut Gjesdal, Sverre Kjeldsen, Knut Liestol, Per Torger Skretteberg, Jan Erikssen, Johan Bodegard
Journal: Circulation (2011)

Aims The prognostic value of a rapid ST-upslope on exercise electrocardiogram (ECG) is unknown among healthy individuals, but it may be associated with a well-balanced control of the autonomic nervous system. We aim to test the hypothesis that rapid ST-upslope is associated with reduced risk of dying from coronary heart disease (CHD). Methods and results A group of healthy middle-aged men (n=2014) participated in a cardiovascular survey examination. They underwent an examination program including a symptom limited ECG bicycle exercise test. Exercise induced ST- segments were categorized in three groups: normal ST-segment (n=1383), rapid ST- upslope (n=401) and ST-depression (n=230). Survival analyses were adjusted for smoking status, total cholesterol, systolic blood pressure, maximal heart rate, and physical fitness. The rapid ST-upslope group was associated with a 30% decreased risk of CHD-death (Hazard Ratio (HR) = 0.70 [95%CI 0.51-0.95]) compared to the normal ST-segment group (see image below). The risk of CVD-death was numerically lower in the rapid ST-upslope group (0.82 [95%CI 0.65-1.04]) compared to the normal ST-segment group. The ST-depression group was associated with a 1.45-fold (HR = 1.45 [95%CI 1.09-1.90]) increased risk of CHD-death compared to the normal ST-segment group. Conclusions The rapid ST-upslope on exercise ECG was a common finding (20%) among healthy middle aged men and was associated with a 30% reduced risk of dying from CHD compared to individuals with normal ST-segment. We suggest that rapid ST-upslope on exercise ECG is the true healthy state.
Abstract 3008: Limitation of Perioperative Inflammation by the Leukocyte Inhibition Module in Patients Undergoing on-pump Cardiac Surgery: The LIMFRA Trial
Authors: Ulf Abdel-Rahman, Tayfun Aybek, Selami Dogan, Feyzan Oezaslan, Harald Keller, Theresa Jeri, Anton Moritz
Journal: Circulation (2009)
FAT1 Expression and Mutation Status In Adult Acute Lymphoblastic Leukemia
Authors: Martin Neumann, Marco Seehawer, Cornelia Schlee, Sebastian Vosberg, Sandra Heesch, Eva von der Heide, Alexander Graf, Stefan Krebs, Helmut Blum, Nicola Gökbuget, Stefan Schwartz, Dieter Hoelzer, Philipp A Greif, Claudia D. Baldus
Journal: Blood (2013)
Abstract 3725: Myocardial Microvascular Obstruction in Sudden Death from Acute Myocardial Infarction Occurs more often in Coronary Plaque Erosion than in Plaque Rupture
Authors: Robert S Schwartz, Allen Burke, Andrew Farb, David Kaye, John R Lesser, Renu Virmani
Journal: Circulation (2008)

Epicardial coronary artery thrombosis is associated with myocardial microvascular obstruction (MVO) and microemboli. Clinical consequences include acute myocardial infarction and sudden cardiac death from myocardial MVO and myocyte necrosis. We thus characterized myocardial histopathology and morphometry and related these findings to epicardial coronary artery plaque in patients dying from coronary artery occlusion. Hearts from patients with proven sudden coronary death from acute coronary artery occlusion underwent histopathologic characterization for MVO, cardiac microemboli, and epicardial coronary artery plaque. Immunohistochemistry was performed on microvascular thrombus to evaluate for platelet and fibrin content. Forty four cases were studied (mean age at death 51 ± 15 yrs). All emboli and MVO thrombus stained for both fibrin and platelets, and occurred in 54% of all patients, mean 4.5 microemboli/heart. Of all occluded microvessels, 89% were less than 120 um diameter (39% were &lt; 30 um dia), and only 4% were greater than 200 um diameter. Microvascular obstruction and emboli occurred more often in epicardial plaque erosion (74% vs 40% of cases with MVO), and was most common in the LAD territory. Histopathologic epicardial coronary stenosis severity was (mean) 74% in those with emboli and 75% in those without (p=ns). Microemboli and microvascular obstruction are very common in patients dying of acute coronary artery thrombosis. Plaque erosion may be most likely to cause such emboli, with accumulation in sub-200 micron vessels. These emboli and microvessel obstruction have a prominent clinical role due to associated myonecrosis. Interventional strategies for eliminating MVO may be useful to limit myocardial damage and prevent long term sequelae.
Predictive response factors (PRF) in an open, nonrandomized, phase II study of a combination of bevacizumab (BZ) and sequential chemotherapy as preoperative treatment in patients with operable HER2-negative breast cancer (BC).
Authors: P. Sanchez Rovira, J. De la Haba, M. Fernández-Navarro, M. Seguí, A. Llombart-Cussac, A. Anton, E. Alba, E. Aranda
Journal: Journal of Clinical Oncology (2010)

556 Background: Association of BZ to chemotherapy in BC improves time to progression of advanced disease. However, limited studies are still available for primary treatment, and PRF are not still clearly determined, above all in HER2-negative patient subgroup receiving antiangiogenic therapy. Objectives: To determine percentage of pathologic complete responses (pCR) in patients diagnosed of locally advanced BC who receive neoadjuvant sequential therapy in association with BZ, as well as to determine the PRF and perform differential analysis of treatment resistant genes. Methods: 72 patients were included in ML20382 clinical trial. Treatment was 4 cycles of doxorubicin/cyclophosphamide 60/600 mg/m2 × 21 days, followed by 4 cycles of BZ 15 mg/kg + docetaxel 75 mg/m2 × 21 days. Median age was 46 years. Stage classification was 20.8% IIA, 43.1% IIB, 23.6% IIIA, 8.3% IIIB, 4.2% IIIC. Median tumour size was 4.75 cm. 68.1% showed axillary affectation and 80.6% were hormone-receptor positive. Clinical evaluation was done by mammography and mammary ultrasound and/or NMR. Tumour samples were collected before treatment and after surgery for analysis of VEGF, VEGFR, EGFR, pAKT, pMAPK, pTEN, HIF, IGF and differential analysis of gene expression. Results: 66 patients evaluated for histopathological response, resulting in 24, 2% of pCR (CI 95%, 14,5-36.4). Multivariate analysis shows a significant increase of responses in ER-negative patients. Treatment was well tolerated, with haematological toxicity G3-4 for 22% of patients (12.5% of neutropenic fever as most noteworthy toxicities). Most relevant non-haematologic toxicity was mucositis G3 for 19.4% and hypertension for 1.4 %. Preliminary analysis shows VEGFr and KISS1 amplification entail a tendency of a lower pCR rate (8.7% and 6.25% respectively). Conclusions: Addition of BZ in preoperative treatment (AC+D) permits a high pCR rate with an adequate safety profile in a subgroup with a median of T > 4 cm and predominantly ER+. VEGFR and KISS1 amplification analysis may identify treatment refractory patient subgroups. No significant financial relationships to disclose.
Abstract 3089: Nurses Ability to Identify Location of Acute ST Elevation Myocardial Infarction on the 12-Lead Electrocardiogram Can be Improved by Using a Simple and Easy to Learn Tool
Authors: Michele M Pelter, Kimberly E Stephens, Holly Anderson, Mary Bryant, Mary G Carey
Journal: Circulation (2006)

Background: Treatment decisions for acute myocardial infarction (MI) rely on rapid and accurate interpretation of the 12-lead electrocardiogram (ECG). Nurses working in acute care settings play a crucial role in communicating ECG findings. Location of acute MI often influences treatment options and helps identify lead specific bedside ECG monitoring for coronary vessel patency and recurrent ischemia. Purpose: The purpose of this prospective study was to determine if a nurse’s ability to identify acute MI location improved by using an easy to learn tool (MI Rule ®) designed for rapid interpretation of 12-lead ECGs for ST elevation MI. Methods: A pre-test, post-test study design was used. Nurses working in the emergency department (ED), coronary care unit (CCU) or progressive care unit (PCU) were asked to evaluate six 12-lead ECGs for the presence and location of ST elevation. The nurses were then given five minutes of educational instruction about how to use the MI Rule ® tool and then asked to evaluate th...
Is the BMJ fit for purpose?
Authors: Oliver R Dearlove
Journal: BMJ (2007)

<h3>Objective:</h3> To develop consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results. <h3>Methods:</h3> A panel of experienced OCT researchers (including 11 neurologists, 2 ophthalmologists, and 2 neuroscientists) discussed requirements for performing and reporting quantitative analyses of retinal morphology and developed a list of initial recommendations based on experience and previous studies. The list of recommendations was subsequently revised during several meetings of the coordinating group. <h3>Results:</h3> We provide a 9-point checklist encompassing aspects deemed relevant when reporting quantitative OCT studies. The areas covered are study protocol, acquisition device, acquisition settings, scanning protocol, funduscopic imaging, postacquisition data selection, postacquisition data analysis, recommended nomenclature, and statistical analysis. <h3>Conclusions:</h3> The Advised Protocol for OCT Study Terminology and Elements recommendations include core items to standardize and improve quality of reporting in quantitative OCT studies. The recommendations will make reporting of quantitative OCT studies more consistent and in line with existing standards for reporting research in other biomedical areas. The recommendations originated from expert consensus and thus represent Class IV evidence. They will need to be regularly adjusted according to new insights and practices.
Abstract 2470: Augmented Tonic Activation Of Chemoreceptors May Contribute To Sympathetic Overactivity In Patients With Essential Hypertension
Authors: Maciej Sinski, Jacek Lewandowski, Joanna Bidiuk, Piotr Abramczyk, Anna Dobosiewicz, Zbigniew Gaciong
Journal: Circulation (2008)

Rationale : Peripheral chemoreflex contributes to regulation of arterial blood pressure and chemoreceptors respond not only to hypoxia but they are also continuously activated by normal ambient oxygen concentration. Stimulation of chemoreceptors activates sympathetic traffic and this response may be altered in subjects with essential hypertension.. Objective: The aim of our study was to investigate the effect of deactivation of carotid body chemoreceptors on sympathetic activity directly measured as MSNA (muscle sympathetic nerve activity) in young subjects with mild to moderate untreated hypertension. Methods: Twelve patients with essential hypertension (36±9 years, all men, BMI 29±4 kg/m 2 ,) and 8 controls (37±7, men BMI 27±5kg/m 2 ) participated in the study. None of the patients or controls received any medications. MSNA (burst/minute and mean burst amplitude - au), systolic blood pressure (SBP) and diastolic blood pressure (DBP), heart rate (HR), ECG, hemoglobin saturation with oxygen (Sat%), end tidal CO 2 and respiratory movements were monitored and measured after 10 minute of respiration by non-rebreathing mask with 100% 0 2 or 21% O 2 applied in blinded fashion. Results: Hypertensives had higher resting MSNA (38.6 ±8.6 burst/min vs. 30.3±.7 burst/min, p&lt;0.05), SBP (149.1± 9.9 vs. 124.1 ±11.6, p &lt; 0.05) and DBP (92.1 ±8.6 vs. 78.1 ± 8.9, p&lt; 0.05) than controls. Breathing with 100% oxygen caused significant decrease in MSNA in hypertensives (from 38.6 ± 8.6 burst/min to 26.3 burst/min ± 6.8 and from 100 ± 0 au to 86 ± 18 au, p&lt; 0.05) and no change in MSNA in controls (30.3 ± 5.7 burst/min initially and 27.3 burst/min ± 6.2 after 100% 0 2 , 100 ± 0 au vs. 98 ± 11 au). Blood pressure, end tidal CO 2 , respiration frequency did not change significantly after hyperoxia while HR decreased (from 69.6 ± 9 to 64.1 ± 7 in hypertensives p&lt;0.05 and from 67± 8 to 62.5 ± 7 in controls, p&lt; 0.05). Sat% increased significantly in both groups to 99%. Conclusions: Increased sympathetic activity in young, untreated hypertensives may be caused by the elevated tonic chemoreflex activation.
Abstract 18842: Left Ventricular Dysfunction Development After Bortezomib Treatment in Patients With Oncologic Diagnoses
Authors: Jorge Romero, Patricia Chavez, Asaf Rabinovitz, Joseph Shatzkes, Haven Caldwell, Carolina Valencia, Mario Garcia
Journal: Circulation (2013)

Background: Bortezomib (VELCADE ®) has been considered a milestone in the treatment of myeloma. Within three years of its approval by the Food and Drug Administration, the first case of severe reversible cardiac failure surfaced in 2006. Objective: Identify the incidence of left ventricular dysfunction in patients that received bortezomib. Methods: We identified 160 patients diagnosed with multiple myeloma, mantle cell lymphoma, plasmocytoma, lymphoma, Waldenstrom’s macroglobulinemia and leukemia, retrospectively. Patients were distributed according to treatment received, in 4 cohorts. Left ventricular dysfunction (LVD) was defined as LVEF&lt;55% by echocardiography. Descriptive analysis was used to identify the incidence of left ventricular dysfunction. CAD evaluation was done by either stress testing or coronary angiogram. Results: One hundred and sixty patients were identified and distributed in 4 cohorts, according to the treatment received: bortezomib (n=74); bortezomib and adriamycin (n=27); adriamycin (n=25) and melphalan (n=34). The mean age was 58 ±13 years and at least 54 % (n=87) were males. Patients were followed in a 21-day to 7-year time-frame period. LVD was present in 20% (15/74); 22% (6/27), 28% (7/25) and 18% (6/34) of patients that received bortezomib, bortezomib and adriamycin, adriamycin and melphalan, respectively. Adriamycin was give prior to bortezomib in combined treatment cohort and before melphalan in the last cohort. Of those who developed LVD at least we identified 5 patients who had CAD (2, 1,1 and 1 for each cohort, accordingly). Conclusion: Bortezomib may be associated with new onset left ventricular dysfunction when given as first line chemotherapy in the treatment of multiple myeloma, mantle cell lymphoma, plasmocytoma, lymphoma, Waldenstrom’s macroglobulinemia and leukemia. It may also potentiate the cardiotoxicity of Adriamycin when used subsequently. Figure. Incidence of left ventricular systolic dysfunction.
Abstract 16151: Exercise Training Decreases Arterial Stiffness and Improves Brain Perfusion in Sedentary Elderly Women
Authors: Yong-Sheng Zhu, Rosemary Parker, Benjamin Tseng, Arjen Van Erkelens, Garrett Coles, Estee Brunk, Kyle Armstrong, Karen Rodrigue, Kristen Kennedy, Denise Park, Rong Zhang
Journal: Circulation (2011)

Arterial aging may contribute to reduction in brain perfusion in older adults. We assessed the hypothesis that aerobic exercise training reduces arterial stiffness and improves brain perfusion in s...
Wandering
Authors: Samuel O. Thier
Journal: Journal of Clinical Investigation (2008)

Dr. Swain, Council members, and members of the AAP, thank you for this singular honor. It is a particular pleasure to have the Medal presented by Denny Ausiello. Denny, who was once my student, is now my chief, which is about as appropriate a sequence as I can imagine. I have titled my response “Wandering.” Wandering aptly describes my career, as Denny so well documented. I have been privileged to have moved easily across geography and professional responsibilities. Wandering is also the title of a small book by one of my favorite authors, Hermann Hesse. In this book, he describes pleasures, insights, and excitement that can come when one crosses boundaries. Those boundaries, as in my case, can be real or metaphorical. Hesse also wrote my favorite book, The Glass Bead Game (Magister Ludi). My father gave me the book when I finished my residency, and after reading about 50 pages of it, I told him it was boring and I didn’t know why he thought I would enjoy it. He told me that I probably was not grown up enough, nor did I have enough responsibilities to appreciate the book, but that perhaps some time in the future I would. As was so often the case, my father was right. When I reread the book a few years later, I understood that it was about Hesse’s concern that the utopian, intellectual, insulated academic community that he had long sought could not survive if that community was too isolated from social responsibility. By the time he published the book in 1943, he had seen the rise of Hitler and what he perceived to be the impotence of the detached intellectual community in combating that rise.
Abstract 4332: Stable Precursor Fragments of Vasoactive Peptides Predict Outcome in Patients with Chronic Heart Failure. Data from the GISSI-Heart Failure Trial
Authors: Serge Masson, Oreste Febo, Ercole Tagliamonte, Marina Floresta, Ospedale V. Cervello, Valentina Milani, Joachim Struck, Andreas Bergmann, Aldo P Maggioni, Gianni Tognoni, Consorzio Mario Negri Sud, Roberto Latini
Journal: Circulation (2008)

The clinical evaluation of several hormones directly involved in the pathophysiology of HF may be hindered by their instability, in particular when dealing with real-life multicenter studies. We assessed the prognostic performance of their stable precursor fragments in patients with chronic HF. Stable fragments of the precursors of atrial natriuretic peptide (mid-regional MR-proANP), endothelin-1 (C-terminal CT-proET-1), adrenomedullin (MR-proADM) and vasopressin (CT-proAVP) were measured at baseline (immunoassays BRAHMS) in 1237 patients with chronic HF enrolled in the multicenter GISSI-HF trial (80.4% males, age 66±11 y, NYHA III-IV 26%, 88% with LVEF&lt;0.40). Association between markers and all-cause mortality (follow-up 3.9 yrs) was tested with multivariable analyses, prognostic discrimination with ROC curves. Plasma levels of MR-proANP (206 [127–322] pM), CT-proET-1 (81 [64 –105] pM), MR-proADM (0.74 [0.58 – 0.97] nM) and CT-proAVP (13.8 [7.56 –24.2] pM) were elevated and correlated with traditional risk factors (age, NYHA class, ischemic etiology, diabetes, atrial fibrillation or COPD). All four biomarkers showed independent association with mortality (HR [95%CI] by medians): MR-proANP 2.52 [1.93–3.30], MR-proADM 1.81 [1.36 –2.40], CT-proET-1 1.79 [1.35–2.36], CT-proAVP 1.54 [1.21–1.98], all p&lt;0.0001) and a prognostic discrimination (AUC range 0.70 – 0.74) similar to BNP (0.72), except for CT-proAVP (0.66). Novel and stable precursor fragments of vasoactive peptides are associated to known clinical risk factors and independently predict outcome in a large representative population of patients with chronic HF.
Abstract 655: Clinical Characteristics of Patients Experiencing Inappropriate Shocks from Primary Prevention ICDs: Findings from the PROSE-ICD Registry
Authors: Alan Cheng, Amanda L Smith, Darshan Dalal, Barbara Butcher, Manish Shah, Eric Bukata, David D Spragg, Charles T Leng, Sunil S Sinha, Henry R Halperin, Saman Nazarian, Hugh Calkins, Ronald D Berger, Gordon F Tomaselli, Joseph E Marine
Journal: Circulation (2008)

Introduction Despite the efficacy of implantable cardioverter defibrillators (ICD) for the prevention of sudden death in patients with dilated cardiomyopathy, inappropriate shocks are not uncommon ...
Filling-in: One or many?
Authors: Luiz Pessoa, Evan Thompson, Alva Noë
Journal: Behavioral and Brain Sciences (2001)

(1) The main issue with regard to modal and amodal completion is not which phenomena are cognitive, and which perceptual. At the level of the animal, both are visuo-cognitive. At the level of visual processing, however, we need to dissect the different functional effects of these kinds of completion. (2) Resonant binding between distributed cortical areas may play a role in perceptual completion, but evidence is needed.
Fallout from the Shipman case
Authors: J M N Hilton
Journal: BMJ (2000)

Fallout from the Shipman case Deaths should be investigated more plainly and effectivelyEditor-O'Neill's editorial and the news article by Dyer, which both arose from the Shipman case, raise several points that merit further consideration. 1 2 The fact that a central registry of doctors' prescribing habits is geared to financial rather than good practice principles perhaps reflects the current fiscal climate.Concern about death certification and coroners dates back to the Brodrick committee. 3 I wonder what was entered on the death certificates of Shipman's patients, how carefully the certificates were scrutinised by the registrar of births, deaths, and marriages, and what was the degree of training and expertise of those scrutinising them.Australian experience mirrors that of the United Kingdom, with inaccuracies in death certificates.Surely, however, characterising the immediate cause of death of valued citizens, irrespective of their age or sex, can never be meddlesome.Inaccuracy in documenting any aspect of medical practice should not be readily accepted.
Abstract 16895: Micrornas Control Endothelial Progenitor Senescence via Regulating Plk2 Expression
Authors: Shoukang Zhu, Shanming Deng, Qi Ma, Taifang Zhang, Degen Zhuo, Liyong Wang, Pascal J Goldschmidt, Chunming Dong
Journal: Circulation (2011)

Background: With advancing age the regenerative properties of somatic stem cells deteriorate in part due to cellular senescence, eventually leading to the diminished repair capability. Endothelial progenitor cells (EPCs) play an important role in angiogenesis. Several miRNAs have been reported to be critical modulators for EPC plasticity. The aim of this study was to determine whether miRNAs regulated age-related senescence in lineage negative bone marrow cells (lin - BMCs) enriched for EPCs. Methods: Lin - BMCs were isolated from young (3-week-old) wild type (WT) and apoE -/- C57BL/6 mice and aged WT (29-month-old) and apoE -/- (12 month-old) mice. Global miRNA and gene expression profiling were analyzed. Results: Using genome-wide miRNA analysis, we found that miR-146a was increased 6.3-fold and 3.4-fold in aged WT and apoE -/- lin - BM cells, respectively, relative to their young counterparts. Microarray analysis showed that the Polo-like kinase 2 (Plk2), a member of the ‘polo’ family of serine/threonine protein kinases that are critical regulators of cell cycle progression or apoptosis, was decreased 18-fold in aged lin - BMC as compared to young cells. Luciferase assay showed miR-146a substantially inhibited WT Plk2-3’-UTR-luciferase activity in 293T cells, but not mutant Plk2-3’-UTR-luciferase reporter. Overexpression of lentiviral-derived miR-146a resulted in reduction of Plk2 expression, increased senescence-associated (SA) β-gal expression and decreased vascular tube formation in young EPCs, whereas miR-146a antagomir rejuvenated aged EPCs, causing increased Plk2 expression, decreased SA β-gal expression and enhanced vascular tube formation. Furthermore, knockdown of Plk2 by its siRNA resulted in increased senescence and diminished vascular tube formation. Conclusions: Using genomic and functional studies, we have discovered miR-146a controls age-associated EPC senescence via regulating Plk2 expression, thus negatively affecting their vascular repair capacity, which may impact atherogenesis. These findings advance our understanding of EPC aging and provide molecular targets for genetic modification to increase the therapeutic efficacy of EPCs in preventing and repairing vascular damage in atherosclerosis.
Pre-Frailty and Risk of Cardiovascular Disease in Elderly Men and Women
Authors: Giuseppe Sergi, Nicola Veronese, Luigi Fontana, Marina De Rui, Francesco Bolzetta, Sabina Zambon, Maria-Chiara Corti, Giovannella Baggio, Elena Debora Toffanello, Gaetano Crepaldi, Egle Perissinotto, Enzo Manzato
Journal: Journal of the American College of Cardiology (2015)