tbuckley/cabot-search huggingface dataset:
Distinct Cognitive Trajectories According to Amyloid Positivity in Non-Alzheimer Disease Dementias
Authors: Hyemin Jang, Min Young Chun, Jihwan Yun, Jun Pyo Kim, Sung Hoon Kang, Hee Jin Kim, Duk L. Na, Eun Hye Lee, Daeun Shin, Hongki Ham, Yuna Gu, Chi-Hun Kim, Sook-Young Woo, Sang Won Seo
Journal: Clinical Nuclear Medicine (2024)

Background The clinical effects of β-amyloid positivity (Aβ+) on copathologies in various dementias remain relatively underexamined. Thus, the present study was conducted to investigate the prevalence and clinical effects of Aβ+ in subcortical vascular cognitive impairment (SVCI) and frontotemporal dementia (FTD). Patients and Methods We enrolled SVCI (n = 583), FTD (n = 152), and cognitively unimpaired (CU) participants (n = 1,249) who underwent Aβ PET scans. The odds of having Aβ+ were subsequently compared among the diagnostic groups (CU, SVCI, and FTD) according to age and apolipoprotein E genotype. Additionally, a linear mixed-effects model was used to investigate the effects of Aβ+ on cognitive trajectories in SVCI and FTD. Results Compared with CU, the SVCI group had a higher prevalence of Aβ+ in the 75 to 90 years age group (adjusted odds ratio, 1.97; 95% confidence interval, 1.36–2.85; P &lt; 0.001), as well as within the apolipoprotein E ε3/ε3 group (adjusted odds ratio, 1.78; 95% confidence interval, 1.20–2.63; P = 0.001), whereas the FTD group showed no difference in Aβ+ prevalence. Aβ+ was associated with a worse cognitive trajectory in SVCI (adjusted β-coefficient = −0.6424; P &lt; 0.001), but not in FTD. Conclusions These findings contribute to our understanding of Aβ biomarker traits in various dementias in Korea.
Perinephric Extramedullary Disease in Multiple Myeloma
Authors: Alex Koichi, Razvan Zemianschi, Fathima Fijula Palot Manzil, Joshua Eichhorn
Journal: Clinical Nuclear Medicine (2024)

Extramedullary disease represents an aggressive form of multiple myeloma occurring outside the skeleton and is a poor prognostic indicator. Extramedullary disease most commonly involves the skin, muscle, pleura, lymph nodes, liver, and central nervous system. Infrequently, extramedullary disease can involve the kidneys or perirenal space. We present 3 cases of perirenal involvement of extramedullary disease on 18 F-FDG PET/CT confirmed with tissue sampling as plasma cell infiltration. Within the limitation of physiologic activity in the kidneys due to 18 F-FDG excretion, close consideration is essential when evaluating multiple myeloma patients for genitourinary involvement as it can resemble other malignancies, hemorrhage, or renal injury.
Prominent Bone Marrow Infiltration in the Appendicular Skeleton in a B-cell Acute Lymphoblastic Leukemia Patient Demonstrated by FDG PET-MRI
Authors: Mengmeng Zheng, Frederick D Grant, Hongming Zhuang
Journal: Clinical Nuclear Medicine (2024)

Leukemia spread in the bone marrow typically is greater in the axial skeleton than in the appendicular skeleton. We report an unusual pattern of FDG-avid bone marrow infiltration that is more prominent in the appendicular skeleton than the axial skeleton in a pediatric patient with B-cell acute lymphoblastic leukemia.
Cell calcification reverses the chemoresistance of cancer cells via the conversion of glycolipid metabolism
Authors: Lihong Zhang, Yandi Sun, Yindan Lin, Hanhui Li, Yuqiao Huang, Ning Tang, Xueyun Zhang, Yin Lu, Vassili A Kovalev, Eduard V Snezhko, Yan Luo, Ben Wang
Journal: Biomaterials (2024)
Heterogeneous Uptake of Al18F-NOTA-FAPI and 18F-FDG in Apical Aneurysm in Apical Hypertrophic Cardiomyopathy
Authors: Yang Xu, Yue-Hong Guo, Min-Fu Yang
Journal: Clinical Nuclear Medicine (2024)

Abstract Apical aneurysm in apical hypertrophic cardiomyopathy (HCM) is a very rare condition in clinical practice. Some studies have reported abnormal uptake of 18 F-FDG and 18 F-FAPI in HCM, respectively. We presented a case of FAPI and FDG imaging in a patient with apical aneurysm in apical HCM, and further analyzed the discrepancy of spatial distribution pattern of these 2 radiotracers.
Outcomes from the International Society of Nephrology Haemolytic Uraemic Syndromes International Forum
Authors: David Kavanagh, Gianluigi Ardissino, Vicky Brocklebank, Romy N. Bouwmeester, Arvind Bagga, Rob ter Heine, Sally Johnson, Christoph Licht, Alison L.T. Ma, Marina Noris, Manuel Praga, Eric Rondeau, Aditi Sinha, Richard J.H. Smith, Neil S. Sheerin, H. Trimarchi, Jack F.M. Wetzels, Marina Vivarelli, Nicole C.A.J. Van de Kar, Larry A. Greenbaum, Adrian Catalin Lungu, Aleksandra Żurowska, Alexandra Gerogianni, Anne Durkan, Anne Schijvens, Anne-Laure Lapeyraque, Anuja Java, Atif Awan, Bianca Covella, Brad Dixon, Carine El Sissy, Caroline Duinevel, Christine Maville, Daniel Turudic, Diana Karpman, Dieter Haffner, Elżbieta Trembecka-Dubel, Fatih Ozaltin, Francesco Emma, Franz Schaefer, Hee Gyung Kang, Hernán Trimarchi, Hernando Trujillo, Ifeoma Ulasi, Alex Ekwueme, Jan Menne, Jeffrey Laurence, Joaquim Calado, Johannes Hofer, Julien Zuber, Jun Oh, Karmila Abu Bakar, Kate Smith Jackson, Daniel Turudic, Danko Milosevic, Diana Karpman, Elżbieta Trembecka-Dubel, Fatih Ozaltin, Francesco Emma, Franz Schaefer, Gema Ariceta, Hee Gyung Kang, Hernán Trimarchi, Hernando Trujillo, Ifeoma Ulasi, Alex Ekwueme, Jan Menne, Jeffrey Laurence, Joaquim Calado, Kathleen J. Claes, Kati Kaartinen, Khalid Alhasan, Kioa Wijnsma, L.P. van den Heuvel, Laura Alconcher, Maria Izabel de Holanda, Maria Szczepańska, Marie-Sophie Meuleman, Mathieu Lemaire, Meredith Harris, Michael G. Michalopulos, Michal Malina, Mihály Józsi, Nataša Stajić, Nicole Isbel, Patrick Walsh, Paula A. Coccia, Raja Ramachandran, Rezan Topaloglu, Sjoerd A.M.E.G. Timmermans, Sophie Chauvet, Tanja Kersnik Levart, Tomas Seeman, Velibor Tasic, Vladimír Tesař, Wen-Chao Song, Yuzhou Zhang, Zoltán Prohászka
Journal: Kidney International (2024)

<h2>Abstract</h2> The haemolytic uraemic syndromes (HUS) are a heterogeneous group of conditions only some of which are mediated by complement (CaHUS). We report the outcome of the 2023 International Society of Nephrology HUS International Forum where a global panel of experts considered the current state of the art, identified areas of uncertainty, and proposed optimal solutions. Areas of uncertainty and areas for future research included: the nomenclature of HUS; novel complement testing strategies; identification of biomarkers; genetic predisposition to aHUS; optimal dosing and withdrawal strategies for C5 inhibitors; treatment of kidney transplantation recipients; disparity of access to treatment; and the next generation of complement inhibitors in CaHUS. The current rationale for optimal patient management is described.
FDG PET/CT in a Case of Esophageal Schwannoma
Authors: Jun Zhang, Xia Ji, Aisheng Dong
Journal: Clinical Nuclear Medicine (2024)

Esophageal schwannoma is very rare. We describe FDG PET/CT findings in a case of benign esophageal schwannoma. Endoscopic ultrasound showed the tumor was located in the muscular layer of the esophagus. FDG PET/CT showed intense FDG uptake with SUV max of 10 of the tumor mimicking malignancy. This case indicates that schwannoma should be included in the differential diagnosis of esophageal FDG-avid lesions.
Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner
Authors: Megan E. Bosch, Hemraj B. Dodiya, Julia Michalkiewicz, Choonghee Lee, Shabana M. Shaik, Ian Q. Weigle, Can Zhang, Jack Osborn, Aishwarya Nambiar, Priyam Patel, Samira Parhizkar, Xiaoqiong Zhang, Marie L. Laury, Prasenjit Mondal, Ashley Gomm, Matthew John Schipma, Dania Mallah, Oleg Butovsky, Eugene B. Chang, Rudolph E. Tanzi, Jack A. Gilbert, David M. Holtzman, Sangram S. Sisodia
Journal: Molecular Neurodegeneration (2024)
Diagnostic Accuracy of 18F-FES PET/CT for the Detection of Recurrent and Metastatic Breast Cancer
Authors: Eonwoo Shin, Sangwon Han, Jeongryul Ryu, Hye-Joung Eom, Woo Jung Choi, Jin-Hee Ahn, Byung Ho Son, Seung Do Ahn, Gyungyub Gong, Dae Hyuk Moon
Journal: Clinical Nuclear Medicine (2024)

To evaluate the diagnostic value of 16α- 18 F-fluoro-17β-fluoroestradiol ( 18 F-FES) PET/CT for distant metastasis or recurrence in patients with estrogen receptor (ER)-positive breast cancer.
To Perform, or Not to Perform Interim PET
Authors: Christoph Wetz, Tristan Ruhwedel, Julian M.M. Rogasch, Peter R. Steinhagen, Felix Bolduan, Holger Amthauer, Imke Schatka
Journal: Clinical Nuclear Medicine (2024)

This study aimed to analyze the impact of interim evaluation on the continuation of 177Lu-based peptide receptor radionuclide therapy (PRRT) in gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and to survey its usage across German university hospitals.
18F-FDG PET/CT in Pediatric INI1-Negative Soft Tissue Myoepithelial Carcinoma
Authors: Karan B. Singh, Monica A. Rossleigh, Eva A. Wegner
Journal: Clinical Nuclear Medicine (2024)

Abstract A 12-year-old girl with no previous comorbidities presented with a left gluteal swelling. 18 F-FDG PET/CT demonstrated heterogenous, moderate hypermetabolism localizing to a very large pelvic soft tissue mass with extension through the left greater sciatic notch into the left deep gluteal space. Core biopsy of the mass revealed INI1-negative myoepithelial carcinoma. Here we report the molecular imaging findings in an extremely rare pediatric case of INI1-negative, soft tissue myoepithelial carcinoma.
Primary Squamous Cell Carcinoma of the Breast With 18F-FDG PET/CT
Authors: Özge Erol Fenercioğlu, Cansu Benli Işık, Mehmet Can Baloğlu, Ediz Beyhan, Nurhan Ergül
Journal: Clinical Nuclear Medicine (2024)

A 67-year-old woman presented with a palpable breast mass. A biopsy was taken, and the diagnosis was squamous cell carcinoma. Primary squamous cell carcinoma of breast is an extremely rare subtype of invasive breast cancer. The diagnosis requires ruling out metastasis of other sites and that is not skin origin. The patient was referred to 18 F-FDG PET/CT for diagnosis and staging. In this report, we present PET/CT and postsurgical pathology findings.
Mildly Increased 68Ga-Pentixafor Uptake in Hepatic Hemangioma
Authors: Lixiang Yang, Mingxing Huang, Rong Tian, Qianrui Li
Journal: Clinical Nuclear Medicine (2024)

68 Ga-pentixafor uptake in hemangioma is rare. We report 68 Ga-pentixafor PET/MRI findings of a hepatic hemangioma in a 54-year-old woman. The images revealed a hyperintense lesion in the right posterior liver on T2-weighted images, with mild pentixafor uptake. The lesion was consistent with typical presentations of a hemangioma on MRI and contrast-enhanced CT.
Correction: Unassisted single-channel transcolonic endoscopic appendectomy for an appendiceal neuroma
Authors: Pei-Rong Xu, Zu-Qiang Liu, Minying Deng, Quan-Lin Li, Pinghong Zhou
Journal: Endoscopy (2024)

Correction to: Unassisted single-channel transcolonic endoscopic appendectomy for an appendiceal neuromaEndoscopy 2024; 56(S 01): E843-E844DOI: 10.1055/a-2418-0958
A Rare Case of Osteoid Osteoma of the Medial Cuneiform Bone at Tibialis Anterior Insertion Confirmed by Bone Scan SPECT/CT
Authors: Pegah Sahafi, Ramin Sadeghi, Alireza Mousavian
Journal: Clinical Nuclear Medicine (2024)

Abstract A 34-year-old man presented with progressive foot pain that was initially on the medial soft tissue but eventually localized to the medial side of midfoot. Despite undergoing various imaging tests and conservative treatments over 2 years, the patient remained undiagnosed. After 6 months, soft tissue and bone involvement were observed on the medial cuneiform. A needle biopsy was inconclusive. Since bone tumor is rare in the medial cuneiform, the patient was referred to our department for 99m Tc-MDP bone scan. The imaging and clinical findings suggested osteoid osteoma as the likely diagnosis, which was confirmed as intraarticular nidus under tibialis anterior attachment, after surgical resection and pathological examination.
Biocompatibility of Water‐Dispersible Pristine Graphene and Graphene Oxide Using a Close‐to‐Human Animal Model: A Pilot Study on Swine
Authors: Paola Nicolussi, Giovannantonio Pilo, Maria Giovanna Cancedda, Guotao Peng, Ngoc Do Quyen Chau, Alejandro De la Cadena, Renzo Vanna, Yarjan Abdul Samad, Tanweer Ahmed, Jeremia Marcellino, Giuseppe Tedde, Linda Giro, Acelya Ylmazer, Federica Loi, Gavina Carta, Loredana Secchi, Silvia Dei Giudici, Simona Macciocu, Dario Polli, Yuta Nishina, Ciriaco Ligios, Giulio Cerullo, Andrea Ferrari, Alberto Bianco, Bengt Fadeel, Giulia Franzoni, Lucia Gemma Delogu
Journal: Advanced Healthcare Materials (2024)

Abstract Graphene‐based materials (GBMs) are of considerable interest for biomedical applications, and the pilot study on the toxicological and immunological impact of pristine graphene (GR) and graphene oxide (GO) using swine as a close‐to‐human provides valuable insights. First, ex vivo experiments are conducted on swine blood cells, then GBMs are injected intraperitoneally (i.p.) into swine. Hematological and biochemical analyses at various intervals indicate that neither GO nor GR cause systemic inflammation, pro‐coagulant responses, or renal or hepatic dysfunction. Importantly, no systemic toxicity is observed. Analysis of a panel of 84 immune‐related genes shows minimal impact of GO and GR. The animals are sacrificed 21 days post‐injection, and transient absorption imaging and Raman mapping show the presence of GO and GR in the mesentery only. Histological evaluation reveals no signs of alterations in other organs. Thus, clusters of both materials are detected in the mesentery, and GO aggregates are surrounded only by macrophages with the formation of granulomas. In contrast, modest local reactions are observed around the GR clusters. Overall, these results reveal that i.p. injection of GBMs resulted in a modest local tissue reaction without systemic toxicity. This study, performed in swine, provides essential guidance for future biomedical applications of graphene.
68Ga-DOTATATE Uptake in Pancreatic Ductal Adenocarcinoma
Authors: Xia Ji, Aisheng Dong, Yang Wang, Changjing Zuo
Journal: Clinical Nuclear Medicine (2024)

Abstract We present a case of pancreatic ductal adenocarcinoma showing increased 68 Ga-DOTATATE uptake mimicking neuroendocrine tumor on PET/CT. Immunohistochemical analyses of the resected tumor showed the tumor cells were negative for somatostatin receptor subtype 2. The nonneoplastic islets scattered throughout the tumor were positive for somatostatin receptor subtype 2, which may be responsible for the increased 68 Ga-DOTATATE uptake. This case indicates that pancreatic ductal adenocarcinoma should be included in the differential diagnosis of the pancreatic lesions showing increased 68 Ga-DOTATATE uptake.
Updated EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection – Update 1
Authors: Martin J van den Bent, Enrico Franceschi, Mehdi Touat, Pim J French, Ahmed Idbaih, Giuseppe Lombardi, Roberta Rudà, Leonille Schweizer, David Capper, Marc Sanson, Pieter Wesseling, Michael Weller, Marica Eoli, Elena Anghileri, Franck Bielle, Phillipp Euskirchen, Marjolein Geurts, Patrick Y Wen, Matthias Preusser
Journal: Neuro-Oncology (2024)

Abstract The standard of care for adult patients with gliomas, glioneuronal, and neuronal tumors consists of combinations of surgery, radiotherapy, and chemotherapy. For many systemic cancers, targeted treatments are a major part of the standard treatment; however, the predictive significance of most of the targets for treatment in systemic cancer is less well-established in central nervous system tumors. In 2023 the European Association for NeuroOncology (EANO) Guideline Committee presented evidence-based recommendations for rational testing of molecular targets for targeted treatments. From all targets reviewed, only testing for BRAF V600E mutations was of proven clinical benefit; despite regulatory approvals for tumor agnostic treatment of NTRK gene fusions and high tumor mutational burden (TMB) for patients with adult brain tumors, the evidence of clinical benefit for adult patients was still limited. This guideline has a modular structure, allowing regular updating of individual sections and adding new ones. The present version (Update 1) presents a review of the rationale of testing for PTEN, H3F3A, MTAP, RET and IDH, and presents an update of the text on TMB high and mismatch repair deficiency. It also presents an overview of the therapeutic yield of routine next-generation sequencing for mutations and fusion detection. The Supplemental File II accompanying this version contains an in-depth review of all targets, whereas, in the main manuscript, the final recommendations of the revised and new targets are presented. Updates will be made on a regular basis.
Topical melatonin: wake up looking younger…?
Authors: Ralf Paus, Sofia M Perez
Journal: British Journal of Dermatology (2024)

Topical melatonin applied over many days and weeks, which might even reduce dermatitis, erythema and sunburn, could be a promising start in the lifelong battle to impede and, ideally, reverse intrinsic and extrinsic human skin ageing.
VSTM2A reverses immunosuppression in colorectal cancer by antagonizing the PD-L1/PD-1 interaction
Authors: Yujuan Dong, Jiaxun Jade Liu, Yunfei Zhou, Wei Kang, Shanglin Li, Alvin H.K. Cheung, Yi Hu, Rui Liao, Nathalie Wong, Chi Chun Wong, Simon S.M. Ng, Jun Yu
Journal: Molecular Therapy (2024)
Efficacy and safety of the anti-IL1RAP antibody nadunolimab (CAN04) in combination with gemcitabine and nab-paclitaxel in patients with advanced/metastatic pancreatic cancer
Authors: Eric Van Cutsem, Joelle Collignon, Rikke L. Eefsen, Sebastian Ochsenreither, Zanete Zvirbule, Audrius Ivanauskas, Dirk Arnold, Edita Baltruskeviciene, Per Pfeiffer, Jeffrey Yachnin, Susanne Magnusson, Camilla Rydberg Millrud, Annika Sanfridson, Nedjad Losic, Ignacio Garcia-Ribas, Dominique Tersago, Ahmad Awada
Journal: Clinical Cancer Research (2024)

Interleukin (IL)-1 pathway upregulation is implicated in pancreatic ductal adenocarcinoma (PDAC) progression, therapy resistance, and survival. Nadunolimab is an IL-1 receptor accessory protein (IL1RAP)-targeting antibody with enhanced antibody-dependent cellular cytotoxicity that blocks IL-1α/IL-1β signaling. We investigated efficacy and safety of nadunolimab in PDAC, in combination with gemcitabine/nab-paclitaxel (GN).
Corrigendum to “Detection and analysis of cerebral aneurysms based on X-ray rotational angiography - the CADA 2020 challenge” [Medical Image Analysis, April 2022, Volume 77, 102333]
Authors: Matthias Ivantsits, Leonid Goubergrits, Jan-Martin Kuhnigk, Markus Huellebrand, Jan Bruening, Tabea Kossen, Boris Pfahringer, Jens Schaller, Andreas Spuler, Titus Kuehne, Yizhuan Jia, Xuesong Li, Suprosanna Shit, Bjoern Menze, Ziyu Su, Jun Ma, Ziwei Nie, Kartik Jain, Yanfei Liu, Yi Lin, Anja Hennemuth
Journal: Medical Image Analysis (2024)
Mesenchymal stromal cells surface engineering for efficient hematopoietic reconstitution
Authors: Huiyang Li, Lifei Ma, Ni Zhu, Xiaoyu Liang, Xinxin Tian, Kaijing Liu, Xue Fu, Xiaoli Wang, Hailing Zhang, Houzao Chen, Qiang Liu, Jing Yang
Journal: Biomaterials (2024)
How many functioning ciliated airway epithelial cells are necessary for effective mucociliary clearance?
Authors: Ruth M. Urbantat, Marcus A. Mall
Journal: European Respiratory Journal (2024)

<h3>Shareable abstract</h3> <b>In the current issue of the <i>European Respiratory Journal</i>, Loges and co-workers use an elegant approach to demonstrate that 30% of normally functioning ciliated epithelial cells may be sufficient to maintain mucociliary clearance <i>in vitro</i> and <i>in vivo</i></b>https://bit.ly/3YHJtpv
Synergistic evolution: the dynamic adaptation of SARS-CoV-2 and human protective immunity in the real world
Authors: Yunhui Li, Xiaohan Zhang, Jingkun Yi, Yuan Chen, Jing Liang, Li Wang, Jiayue Ma, Renlong Zhu, Xiaomei Zhang, Di Hu, Yan Jia, Xiaobo Yu, Yajie Wang
Journal: Journal of Infection (2024)
Reversible carfilzomib-induced pulmonary arterial hypertension: don't take your eyes off the ball!
Authors: Laura C. Price, Alex Lyon, Kevin Boyd
Journal: European Respiratory Journal (2024)

<h3>Shareable abstract</h3> <b>The proteasome inhibitor myeloma therapy, carfilzomib, is an increasingly reported cause of drug-induced PAH, which can be reversible. This case highlights the complexity of close monitoring for further pulmonary vascular complications during follow-up.</b> https://bit.ly/3yvHxpk
Microneedle Transdermal Delivery of Compound Betamethasone in Alopecia Areata - A Randomized Controlled Trial
Authors: Rui Qiao, Jiaping Zhu, Jing Fang, Hualing Shi, Ziye Zhang, Jin Nie, Yiping Ge, Tong Lin, Yiqun Jiang
Journal: Journal of the American Academy of Dermatology (2024)
Comprehensive metabolomic analysis identifies key biomarkers and modulators of immunotherapy response in NSCLC patients
Authors: Se-Hoon Lee, Sujeong Kim, Jueun Lee, Yunjae Kim, Yanghyun Joo, Jun-Yeong Heo, Heeyeon Lee, Charles Lee, Geum-Sook Hwang, Hansoo Park
Journal: Drug Resistance Updates (2024)
Pembrolizumab Plus Chemotherapy for Advanced and Recurrent Cervical Cancer: Final Analysis According to Bevacizumab Use in the Randomized KEYNOTE-826 Study
Authors: D. Lorusso, N. Colombo, C. Dubot, M.V. Cáceres, K. Hasegawa, R. Shapira-Frommer, P. Salman, E. Yañez, M. Gümüş, M. Olivera, V. Samouëlian, V. Castonguay, A. Arkhipov, K. Li, S. Toker, C. Tekin, K.S. Tewari, B.J. Monk
Journal: Annals of Oncology (2024)
Suppression of aldehyde dehydrogenase 2 in kidney proximal tubules contributes to kidney fibrosis through Transforming Growth Factor-β signaling.
Authors: I-Jen Chiu, Amrendra K Ajay, Che-Hong Chen, Shreyas Jadhav, Li Zhao, Minghua Cao, Yan Ding, Kavya M Shah, Sujal I Shah, Li-Li Hsiao
Journal: Kidney International (2024)
Biomimetic Polymeric Nanoreactors with Photooxidation-Initiated Therapies and Reinvigoration of Antigen-Dependent and Antigen-Free Immunity
Authors: Pu Qiu, Mei Wen, Zixuan Zhuang, Shining Niu, Cheng Tao, Nuo Yu, Zhigang Chen
Journal: Biomaterials (2024)