tbuckley/cabot-search huggingface dataset:
Abstract 17979: A Genome-Wide Association Study of Risk of Coronary Artery Disease in European and South Asian Populations
Authors: Jemma C Hopewell, John Peden, Danish Saleheen, John Chambers, Robert Clarke, Rory Collins, John Danesh, Panos Deloukas, Paul Elliott, Martin Farrall, Jorg Hager, Anders Hamsten, Jaspal Kooner, Mark Lathrop, Sarah Parish, Hugh Watkins
Journal: Circulation (2010)

Background: Genome-wide association (GWAS) studies of coronary artery disease (CAD) have identified several common variants for CAD susceptibility, but these explain only a small fraction of the pr...
Defining Left Ventricular Apex-to-Base Twist Mechanics Computed From High-Resolution 3D Echocardiography
Authors: Muhammad Ashraf, Andriy Myronenko, Thuan Nguyen, Akio Inage, Wayne Smith, Robert I. Lowe, Karl Thiele, Carol A. Gibbons Kroeker, John V. Tyberg, Jeffrey F. Smallhorn, David J. Sahn, Xubo Song
Journal: JACC. Cardiovascular imaging (2010)
Abstract 14449: Worsening Sleep Disordered Breathing is Associated with Lower Peak Oxygen Consumption in Patients with Hypertrophic Cardiomyopathy
Authors: Tomas Konecny, Ondrej Ludka, Marek Orban, Muaz M Abudiab, Peter A Brady, Alexander L Placek, Abhijeet Doble, Paula Macedo, Vladimir Konecny, Tomas Kara, Jan Trna, Thomas G Allison, Jamil A Tajik, Steve R Ommen, Virend K Somers
Journal: Circulation (2010)

Background: Peak oxygen consumption per unit time (pkVO2) is the best and most reproducible measure of cardiopulmonary fitness. It predicts survival in patients with left ventricular systolic dysfu...
23-valent pneumococcal vaccination and HIV [2] (multiple letters)
Authors: Tandakha Dieye, Thierry Simonart, Papa Salif Sow, Claire Farber, Vana Spoulou, Maria Theodoridou, Vassiliki V.G. Papaevangelou, Glykeria G.I. Mostrou, John P A Ioannidis
Journal: The Lancet (2000)
The Influence of Heredity on the Occurrence of Cancer in Animals
Authors: H. Gideon Wells
Journal: Annals of Internal Medicine (1931)

Article1 January 1931The Influence of Heredity on the Occurrence of Cancer in AnimalsH. GIDEON WELLSH. GIDEON WELLSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-7-676 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn order to keep within the time limit I propose to present my material in the form of a brief synopsis to be followed by a series of lantern slides which will serve to illustrate some of the points I hope to make.The justification of speaking on the subject of cancer in animals before a group of men interested in human medicine lies in the fact that it would seem that our best prospect of obtaining reliable information concerning the influence that heredity may play in the occurrence of cancer will come through the study of cancer in animals.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Presented in the Symposium on Cancer before the American College of Physicians, Minneapolis, Feb. 13, 1930. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1931Volume 4, Issue 7Page: 676-680KeywordsHeredity ePublished: 1 December 2008 Issue Published: 1 January 1931 PDF downloadLoading ...
Abstract 8710: A Crucial Role of Nox2 In Middle-Age Obese-Related Hyperglycaemia and Endothelial Dysfunction in Mice
Authors: Junjie Du, Jian-mei Li
Journal: Circulation (2011)

Middle-age obese is often associated with multiple organ oxidative stress and is a major risk factor for the development of cardiovascular diseases. In this study, we investigated the role of Nox2, a superoxide-generating enzyme, in a mouse model of high fat diet-induced middle-age metabolic disorders and vascular dysfunction. Littermates of C57BL/J6 wild-type and Nox2 knockout mice (7 m old, n=10) were fed with high fat diet (HFD, 45% kcal fat, 20% kcal protein and 35% kcal carbohydrate) or normal chow diet (NCD, 12% kcal fat, 28% kcal protein and 60% kcal carbohydrate) for 16 weeks, and were used at 11 m of age Compared to age-matched NCD-fed mice, wild-type mice fed with HFD showed significant increases in body weight (NCD 42±2.3 vs HFD 56±3.2g) and the levels of fasting glucose (NCD 7.4±3.3 vs HFD 8.8±2.2 mM). These metabolic changes were accompanied by significant increases (42±5%) in NADPH-dependent ROS production by aortas as measured by lucigenin-chemiluminescence, and a decrease in endothelium-dependent vessel relaxation to acetylcholine (Emax NCD 80.45±7.39% vs HFD 74.41±1.74%) as assessed by an organ bath. The systolic BP was also significantly elevated (NFD 127±8 vs HFD 142±12mmHg) (all P&lt;0.05). Compared to WT mice, Nox2 knockout mice fed with HFD had similar scale of increase in body weight (NCD 38±3.6 vs HFD 49±2.6g, P&lt;0.05). However, there was no significant increase in the levels of fasting glucose (NCD 7.5±0.8 vs HFD 6.7±1.5 mM). The aortic NADPH-dependent ROS production remained unchanged and the endothelium- dependent vessel relaxation to acetylcholine was well preserved (Emax NCD 80.53±11.3 vs HFD 78.18±5.6%). There was no significant increase in systolic BP (NCD 123±14 vs HFD130±9mmHg) in HFD-fed Nox2 knockout mice. In conclusion, Nox2 and Nox2-derived ROS play a key role in mediating dietary obesity-related hyperglycaemia and endothelial dysfunction after middle-age, and Nox2 may present a therapeutic target for the prevention and treatment of these diseases.
Cor Pulmonale Parvus in Chronic Obstructive Pulmonary Disease and Emphysema
Authors: Steven M. Kawut, Hooman D. Poor, Megha A. Parikh, Katja Hueper, Benjamin M. Smith, David A. Bluemke, João A.C. Lima, Martin R. Prince, Eric A. Hoffman, John H.M. Austin, Jens Vogel-Claussen, R. Graham Barr
Journal: Journal of the American College of Cardiology (2014)
Books: Biotechnology in Healthcare
Authors: R. Walker
Journal: BMJ (1999)

Ed Gavin Brooks 

Pharmaceutical Press, £19.95, pp 228

ISBN 085369 372 2

Rating: ![Graphic][1] ![Graphic][2] ![Graphic][3] 

“Wrong man, wrong book to review,” I thought on receiving Biotechnology in Healthcare , “What's the relevance of this to a clinician or a health authority bureaucrat like me?” But on the plus side, it was only 228 pages long and had a statement on the cover that it was written for the healthcare profession, so I accepted the invitation to review.

For those a little rusty on …

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Dutch euthanasia procedures relaxed
Authors: T. Sheldon
Journal: BMJ (1997)

The Dutch cabinet has announced plans to allow doctors who take part in euthanasia and assisted suicide to have their cases reviewed by regional committees of doctors, lawyers, and ethicists. They will judge if the strict guidelines for good medical practice have been followed and report to the public prosecution department.

In the rare cases when doctors have acted without a specific request, such as with severely handicapped newborn babies and patients who have been in …
The Elusive Right to Health Care under U.S. Law
Authors: Jennifer Prah Ruger, Theodore W. Ruger, George J. Annas
Journal: New England Journal of Medicine (2015)

There is no right to health care in the U.S. Constitution, but Congress has incrementally established health care rights through legislation, including laws creating Medicare and Medicaid, the Emergency Medical Treatment and Active Labor Act, and the Affordable Care Act.
Chronic Traumatic Encephalopathy: The Neuropathological Legacy of Traumatic Brain Injury
Authors: Jennifer Hay, Victoria E. Johnson, Douglas H. Smith, William Stewart
Journal: Annual Review of Pathology Mechanisms of Disease (2016)

Almost a century ago, the first clinical account of the punch-drunk syndrome emerged, describing chronic neurological and neuropsychiatric sequelae occurring in former boxers. Thereafter, throughout the twentieth century, further reports added to our understanding of the neuropathological consequences of a career in boxing, leading to descriptions of a distinct neurodegenerative pathology, termed dementia pugilistica. During the past decade, growing recognition of this pathology in autopsy studies of nonboxers who were exposed to repetitive, mild traumatic brain injury, or to a single, moderate or severe traumatic brain injury, has led to an awareness that it is exposure to traumatic brain injury that carries with it a risk of this neurodegenerative disease, not the sport or the circumstance in which the injury is sustained. Furthermore, the neuropathology of the neurodegeneration that occurs after traumatic brain injury, now termed chronic traumatic encephalopathy, is acknowledged as being a complex, mixed, but distinctive pathology, the detail of which is reviewed in this article.
Abstract 16559: Right Ventricular Volume and Functional Change Following Surgical Pulmonary Valve Replacement in Adults With Congenital Heart Disease.
Authors: Heiko Schneider, Helen Dormand, Jaspal S Dua, Bernard Clarke, Ragheb Hasan, Andreas J Hoschtitsky, Vaikom S Mahadevan
Journal: Circulation (2011)

Purpose: To assess postoperative changes in right ventricular volumes and function in adults undergoing surgical pulmonary valve replacement (PVR) in the setting of previously treated congenital he...
COLLEGES OF PHYSICIANS
Authors: G F STRONG
Journal: Annals of Internal Medicine (1956)

Article1 July 1956COLLEGES OF PHYSICIANSG. F. STRONG, F.A.C.P., F.R.C.P.(London), F.R.C.P.(C), F.R.A.C.P.G. F. STRONG, F.A.C.P., F.R.C.P.(London), F.R.C.P.(C), F.R.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"Profound, sad and discrete, groundedly learned, and deeply studied in physic"1—in these words, in the year 1518, the College of Physicians of London set out its requirements for members. The College was conceived by Thomas Linacre, the distinguished Englishman, whose education combined the trainings of humanist and physician. He took the degree of Doctor of Medicine at Padua with such a brilliant record, that on his return to England, he was promptly given a Doctorate in Medicine by both Oxford and Cambridge. Linacre remained at Oxford for a time, establishing a notable reputation as a Greek scholar, and translating into...Bibliography1. Himsworth H: The integration of medicine, British M. J. 2: 217 (July 23) 1955. CrossrefMedlineGoogle Scholar2. Editorial: British M. J. 1: 607 (April 3) 1913. Google Scholar3. Barr DP: Hazards of modern diagnosis and therapy—the price we pay, J. A. M. A. 159: 1452 (Dec. 10) 1955. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Vancouver, B.C., Canada*Presidential Address, Thirty-Seventh Annual Session, Los Angeles, California, April 18, 1956.Requests for reprints should be addressed to G. F. Strong, M.D., 925 Georgia St., Vancouver, B.C., Canada. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInheritance of Rheumatoid ArthritisFamilial aggregation and rheumatoid diseaseThyroid Function and Clinical Coronary Heart DiseaseStruma und Pers�nlichkeitsreifung 1 July 1956Volume 45, Issue 1Page: 1-6 ePublished: 1 December 2008 Issue Published: 1 July 1956 Copyright & PermissionsCopyright ©, 1956, by The American College of PhysiciansPDF downloadLoading ...
Targeting of Aquaporin-1 to Apical and Basolateral Membranes Confers Transcellular Osmotic Water Permeability to Transfected Llc-Pk1 and Mdck Cells
Authors: P.M.T. Peen, S. Nielsen, R.J.M. Bindels, C.H. van Os
Journal: Journal of the American Society of Nephrology (1995)
Enforced Expression of GATA-2 Confers Quiescence on Human Hematopoietic Stem and Progenitor Cells In Vitro and In Vivo.
Authors: Alex J. Tipping, Cristina Pina, Anders Castor, Ann Atzberger, Dengli Hong, Lorenza Lazzari, Gillian May, Sten Eirik Jacobsen, Tariq Enver
Journal: Blood (2006)
Abstract 10648: Matrix Metalloproteinase-8 Promotes Vascular Smooth Muscle Cell Proliferation and Neointima Formation
Authors: Qingzhong Xiao, Feng Zhang, Gianluca Grassia, Yanhua Hu, Zhongyi Zhang, Qiuru Xing, Xiaoke Yin, Marcella Maddaluno, Binia Drung, Boris Schmidt, Pasquale Maffia, Armando Ialenti, Manuel Mayr, Qingbo Xu, Shu Ye
Journal: Circulation (2012)

BACKGROUND: The pathogenesis of atherosclerosis and post-angioplasty restenosis involves migration and proliferation of vascular smooth muscle cells (VSMCs) which constitute a major component of at...
Guest Editor’s Forward
Authors: Louxin Zhang
Journal: Genomics Proteomics & Bioinformatics (2005)

This is the special issue devoted to bioinformatics research in Singapore. Bioinformatics research in Singapore started largely in 1996 when the Bioinformatics Center, National University of Singapore, was formed. With the government’s efforts to turn Singapore into a powerhouse of biomedical research, the Genome Institute of Singapore and the Bioinformatics Institute of Singapore have been established since 2000. Recently, a bioinformatics research center was also formed in the Nanyang Technological University. Currently, there are a large number of bioinformatics research teams in each of these institutions. The biological focuses of the selected papers in this special issue span a very wide range of computational biology and represent several research projects that are undergoing in Singapore: 1. Kong and Han’s invited review paper covers the biological and computational perspectives of microRNA, a hot subject in molecular biology and genomics. 2. Li and Leong’s paper is about the feature selection for the prediction of translation initiation sites. 3. Wu, Liu, Xu, Peng, and Setiono’s paper analyzes the genome-wide gene expression in the Zebrafish genome. 4. Sun, Zhou, and Lin’s paper studies the evolution of the RhoGEF-containing protein domains. Kui Lin had worked in the Bioinformatics Center, National University of Singapore, and then in the Genome Institute of Singapore for several years before moving back to Beijing recently. 5. Yao, Xiao, Tung, and Sung’s paper investigates the problem of identifying common substructures of proteins. 6. Nguyen, Ngo, and Nguyen’s paper studies the genome rearrangement with weighted, lengthrestricted reversals. These papers have been subjected to the normal refereeing process and have undergone revision. I am grateful to the authors and especially the referees for making this special issue possible.
Advanced Pulmonary Tuberculosis
Authors: Lewis J. Moorman
Journal: Annals of Internal Medicine (1932)

Article1 February 1932Advanced Pulmonary TuberculosisLEWIS J. MOORMAN, M.D., F.A.C.P.LEWIS J. MOORMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-8-1022 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor many decades the dominant theme of practically all discussions dealing with clinical tuberculosis has been early diagnosis and early treatment. While the significance of this theme is perfectly obvious and the difficulty of early diagnosis universally admitted, there still seems to be a general lack of interest in tuberculosis. This may be accounted for in part by the fact that, until recently, we have been unable to offer any constructive variation in a program which often proved inadequate. It is not surprising that many members of the profession not particularly intrigued by the interesting game of physical diagnosis, and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oklahoma City, Oklahoma*Clinic presented at the University of Maryland, School of Medicine, University Hospital, in the Fifteenth Annual Clinical Session of The American College of Physicians.†Professor of Clinical Medicine, University of Oklahoma. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1932Volume 5, Issue 8Page: 1022-1027KeywordsGamesHospital medicine ePublished: 1 December 2008 Issue Published: 1 February 1932 PDF downloadLoading ...
Romidepsin Is Effective and Well-Tolerated In Patients ≥ 60 Years Old With Relapsed Or Refractory Peripheral T-Cell Lymphoma (PTCL): Analysis From Phase 2 Trials
Authors: Andrei R. Shustov, Bertrand Coiffier, Steven M. Horwitz, Lubomir Sokol, Barbara Pro, Tina Nielsen, Julie Wolfson, Barbara E Balser, Robin Eisch, Leslie Popplewell, Miles Prince, Steven L. Allen, Richard Piekarz, Susan E. Bates
Journal: Blood (2013)
P0034 : Good outcome of patients transplanted with meld score greater than 30: Paul-brousse hospital experience
Authors: F. Artru, A. Louvet, P. Ichaï, J. Berthaux, A. Coilly, M. Boudon, T. Antonini, E. De Martin, E. Vibert, D. Samuel, F. Saliba
Journal: Journal of Hepatology (2015)
Abstract 9717: The New ISHLT Cardiac Allograft Vasculopathy Coronary Angiogram Grading Scale: Does it Have Prognostic Relevance?
Authors: Jignesh Patel, Michelle Kittleson, Pranav Kansara, Matthew Rafiei, Lily Stern, David Chang, Babak Azarbal, Lawrence Czer, Fardad Esmailian, Jon Kobashigawa
Journal: Circulation (2012)

Purpose: The International Society for Heart and Lung Transplantation (ISHLT) has recently established a cardiac allograft vasculopathy (CAV) nomenclature scale to standardize coronary angiography reporting. In general, the new grading scheme is represented by CAV 0 , no disease; CAV 1 , mild disease; CAV 2 , moderate disease; CAV 3 , severe disease. Restrictive cardiac physiology associated with CAV 1 or CAV 2 will automatically place them into CAV 3 . It has not been established whether increasing CAV grade truly correlates to worse outcome after heart transplantation. In addition, the impact of restrictive cardiac physiology (in this grading scheme) on outcome has not been well established. Methods: Between 1994 and 2010, we reviewed 1,341 heart transplant patients (pts) and divided them according to first diagnosis of an abnormal specific CAV grade. All pts were then subsequently followed for 5 year actuarial survival after first diagnosis of that specific CAV grade. We also assessed the impact of restrictive physiology on subsequent actuarial 5-year survival in the CAV 3 group. Results: 5-year subsequent actuarial survival following first time diagnosis of CAV category showed worsening survival from CAV 1 (n=219), CAV 2 (n=96), CAV 3 (n=50) pts (80%, 63%, 52% respectively, p&lt;0.001)(figure). In the CAV 3 group, pts with restrictive cardiac physiology had worse 5-year subsequent actuarial survival compared to those without (41% vs. 58%, p=0.07). Conclusion: The new ISHLT CAV nomenclature grading scale appears to predict outcome after heart transplant. Addition of restrictive cardiac physiology as inclusion criteria for CAV 3 grade appears justified as it infers worse prognosis.
Abstract 9815: Cardioprotective Effect Of Neuregulin-1 In Myocardial Ischemia-Reperfusion Injury Relies On eNos.
Authors: Katrien Lemmens, Anne-Sophie Hervent, Marc Demolder, Gilles De Keulenaer
Journal: Circulation (2011)

Background: The neuregulin-1 (NRG1)/erbB system is an endothelium-controlled paracrine system, which protects the heart during myocardial stress. Subcellular mechanisms of this protection have not been identified. We previously observed that NRG1 activates cardiomyocyte endothelial nitric oxide synthase (eNOS), leading to desensitization of the myocardium for beta-1-adrenergic inotropic effects. In this study, we tested whether eNOS also participates during NRG1-mediated protection against myocardial ischemia-reperfusion (I/R) injury. Methods: C57BL/6 (wild type, WT) and eNOS knockout (KO) mice were pre-treated with rNRG1 (20μ g/kg/d, ip) or vehicle for 3 days. Next, they were subjected to 30 min of ischemia by coronary artery ligation, followed by 4h reperfusion. Sham operated littermates served as control. Investigators were blinded for pre-treatment of mice. Results: Left ventricular (LV) NRG1 expression, erbB2 and erbB4 receptor activity remained unaffected by I/R injury (30min/4h) or by genetic background. rNRG1 significantly increased LV erbB2 and erbB4 phosphorylation in WT and KO mice. I/R injury blunted eNOS phosphorylation in WT mice (-57±15%, p&lt;0,05), which was completely prevented by rNRG1. In WT mice, rNRG1 reduced infarct area by 9±2% as compared to vehicle. In contrast, rNRG1 had no effect on infarct area in eNOS KO mice (= 7/group, p =0.001 for NRG1 treatment, p=0.02 for interaction). Also, in WT but not in eNOS KO mice, rNRG1 increased fractional shortening by 11±4% (p&lt;0.05). Interestingly, rNRG1 reduced polymorphonuclear cell influx into infarct and border zones in WT (157±17 cells/mm 2 in vehicle versus 78±18 cells/mm 2 in NRG1 treated WT mice) but had no effect on polymorphonuclear influx in eNOS KO (144±15 cells/mm 2 in vehicle versus 126±10 cells/mm 2 in NRG1 treated KO mice, p=0.008 for NRG1 treatment, p=0.07 for interaction). Conclusions: An activated NRG1/erbB system prevents blunting of myocardial eNOS phosphorylation during I/R, and attenuates myocardial I/R injury. These events are causally related as indicated by the loss of rNRG1-induced protection in eNOS KO mice.
Expression profile of hepatic drug transporters in patients with hepatocellular carcinoma
Authors: K. Higuchi, T. Terada, K. Ogasawara, M. Aoki, M. Fukudo, T. Katsura, E. Hatano, I. Ikai, K. Inui
Journal: Journal of Clinical Oncology (2009)

e22026 Background: Hepatocellular carcinoma (HCC) does not respond sufficiently to chemotherapy. It has been demonstrated that several transporters can cause drug resistance in tumor cells. In human liver, various drug transporters are expressed and play pivotal roles in hepatic uptake and excretion of drugs. In HCC, the expression profile of hepatic drug transporters may be altered due to pathophysiological changes. However, limited data are available on their expression and regulation in HCC tissues. The aims of this study were to determine the expression levels of hepatic drug transporters in HCC patients and to identify transporter specifically regulated in HCC tissues. Methods: The mRNA expression levels of 17 drug transporters, including 9 solute carrier (SLC) transporters (OAT2, OAT7, OATP1B1, OATP1B3, OATP2B1, OCT1, OCTN2, MATE1 and PEPT1) and 8 ATP-binding cassette (ABC) transporters (R1, MRP1–6 and BCRP), were determined by real-time RT-PCR in cancerous and non-cancerous liver tissues from 57 patients with HCC. Protein expression level was evaluated by Western blot analysis. In addition, DNA methylation status in promoter region of transporter gene was analyzed using bisulfite sequencing. Results: The mRNA expression levels of 11 transporters (OAT7, OCTN2, MATE1, PEPT1, R1, MRP1–6) were significantly increased (1.45 to 4.74-fold, p&lt;0.05) in HCC tissues compared with non-cancerous liver tissues, whereas only OCT1 mRNA was significantly decreased (0.61-fold, p=0.0004). Notably, MRP4 mRNA showed the highest increase, which was consistent with the marked augmentation in the protein level. The frequency of methylation in MRP4 promoter region was comparable between HCC and non-cancerous liver tissues, suggesting other mechanisms than DNA methylation for MRP4 up-regulation. Interestingly, the mRNA expression levels of MRP4 did not change with the differentiation of HCC. Conclusions: It was revealed that most of the hepatic drug transporters were elevated in HCC tissues. Furthermore, we first identified that MRP4 showed remarkable increase in protein as well as mRNA expression levels. These findings suggest that MRP4 is a novel candidate for diagnostic marker and a target molecule to reverse multidrug resistance in chemotherapy for HCC. No significant financial relationships to disclose.