Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis
Authors: Lorraine B. Ware, D. Clark Files, Alpha Fowler, Michael S. Aboodi, Neil R. Aggarwal, Roy G. Brower, Steven Y. Chang, Ivor S. Douglas, Scott Fields, Andrea S. Foulkes, Adit A. Ginde, Estelle S. Harris, Gregory W. Hendey, R. Duncan Hite, Weixing Huang, Poying Lai, Kathleen D. Liu, B. Taylor Thompson, Michael A. Matthay, Jay S. Steingrub, Howard Smithline, Mark Tidswell, Lori Kozikowski, Sherell Thorton-Thompson, Lesley DeSouza, Cynthia Kardos, Sarah Romain, Scott Oullette, Peter Hou, Rebecca M. Baron, Christopher Hansen, Victor Pinto Plata, Yuxiu Lei, Richard Riker, Christine Lord, Meghan Searight, Nathan I. Shapiro, Daniel Talmor, Valerie Goodspeed, Bryan Stenson, Joshua Ellis, Alon Dagan, Tatyana Shilvkina, Rupinder Sekhon, Carlo Ottanelli, Ana Grafals, Kim Redman, Madhavan Das, Nadim Kattouf, Alessio Barca, Alexander Weingart, Michael R. Filbin, Kathryn Hibbert, Blair Alden Parry, Justin Margolin, Alan E. Jones, James Galbraith, Utsav Nandi, Carolyn Hendrickson, Kirsten Kangelaris, Taarini Hariharan, Rachel Groper, Kimia Ashktorab, Anika Agrawal, Emma Schmiege, Hanjing Zhuo, Carolyn Leroux, Steven Y. Chang, Gregory W. Hendey, George Lim, Hena Sihota, Joseph E. Levitt, Jenny G. Wilson, Angela J. Rogers, Rosemary Vojnik, Shreya Battu, Cynthia Perez, Timothy E. Albertson, Brian Morrissey, Katherine Wick, Erin Hardy, Ruchira Puri, Tessa Hafenstein, Alyssa Hughes, Eyad Almasri, Shelly Hibbard, Bela Patel, Bindu Akkanti, Pratik Doshi, Gabriel Patarroyo Aponte, Ryan Huebinger, Elizabeth Vidales, Idorenyin Udoh-Bradford, Neil Aggarwal, Adit A. Ginde, Jeffrey McKeehan, Carrie Higgins, Ashley Licursi, Jennifer Fickes-Siler, Suzanne Slaughter, Emily Johnson, Ivor S. Douglas, Jason Haukoos, Stacy Trent, Terra Hiller, Carolynn Lyle, Ana Garcia, Stephnie Gravitz, Darwin Tran, Mia Lundin, Julie Dunn, Eric Stevens, Nikiah Nudell, Bridget Baxter, Scott Bins, Brittany Smoot, Nichol Huckins, Ivan N. Co, Pauline K. Park, Robert Hyzy, Kristine Nelson, J. Victor Jiminez, Normal Olbrich, Jakob I. McSparron, Elizabeth Munroe, Phillip Choi, Shijing Jia, Robert Sherwin, Thomas Mazzocco, Lauren Buck, Teja Pandrangi, Jennifer Swiderek, Emanuel P. Rivers, Jasreen Kaur Gill, Jacqueline Day, Anja Kathrina Jaehne, Michelle Ng Gong, Ari Moskowitz, Amira Mohamed, Martha Torres, Ofelia Garcia, Luke Andrea, Brenda Lopez, Sabah Boujid, Manuel Hache Marliere, Lynne D. Richardson, Samuel Acquah, Neha Goel, Patrick Maher, Cameron Hypes, Elizabeth Salvagio Campbell, Anitza Lopez, Mary Labus, Kristin M. Hudock, R. Duncan Hite, Hammad Tanzeem, Harshada More, Ashraf Khallaf, Benjamin Williams, Abhijit Duggal, Siddharth Dugar, Simon Mucha, Omar Mehkri, Kiran Ashok, Caleb Chang, Sonal Pannu, Matthew Exline, Henry Wang, Sarah Karow, Gabrielle Swoope, Maryiam Khan, David Smith, Madison So, Elli Schwartz, M. Kelly Johnson, D. Clark Files, Chawick Miller, Kevin W. Gibbs, Lori Flores, Lisa Parks, Leigha Landreth, Lauren Koehler, Alpha A. (Berry) Fowler, Marjolein de Wit, Jessica Mason, Aamer Syed, Xian Qiao, Kate Mitchell, Nicholas J. Johnson, Bryce R.H. Robinson, Stephanie Gundel, Megan Fuentes, Maranda Newton, Emily Peterson, Kathryn Thompson, Armando Rodriguez, Thomas Paulsen, Ashdeep Kaur, Catherine L. Hough, Molly Ward, Madeline McDougal, Efrain Chavez Martinez, Edlyn Wolwowicz, Otmar Borchard, Akram Khan, Peter Chen, Ethan Paschal, Po-En Chen, Yunkee Choi-Kuaea, Shane O'Mahony, Julie Wallick, Alexandria Duven, Dakota Fletcher, Alexandria Weissman, Donald Yealy, Denise Scholl, Bryan J. McVerry, David T. Huang, Michael A. Turturro, Derek C. Angus, Jordan Schooler, Lawrence E. Kass, Nina T. Gentile, Nathaniel Marchetti, Hannah Reimer, Andrew J. Goodwin, Abby Grady, Caitlan Lematty, Charles Terry, Melissa Blender, Jeffrey Sturek, Mark Sochor, Mary Marshall, Ashley Simpson, Nikhil Patel, Bryce Taylor, Daxita Patem, Jessica Kearney-Bryan, Daniel Knox, Lindsay M. Leither, Michael Lanspa, Samuel M. Brown, Ithan Peltan, Andrew Gray, Valerie Aston, Tyler Burke, Joshua Jeppsen, Hunter Marshall, Carolyn Klippel, Brent Armbruster, Darrin Applegate, Estelle Harris, Elizabeth A. Middleton, Sean J. Callahan, Lindsey J. Waddoups, Misty B. Yamane, Macy AG Barrios, Nancy Wickersham, Nathan Putz, Samantha Gonski, Jason Lin, Nury Lee, Todd Rice, Lorraine Ware, Wesley H. Self, Margaret Hays, Matthew W. Semler, Liza Frawley, David A. Schoenfeld, B. Taylor Thompson, Douglas L. Hayden, Nancy Ringwood, Cathryn Oldmixon, Richard Morse, Ariela Muzikansky, Laura Fitzgerald, Adrian Lagakos, Weixing Huang, Pouing Lai, Grace Carey, Roy G. Brower, Antonello Punturieri, Lora A. Reineck, Karen Beinstock, Ejigayehu Demissie, Michelle Freemer, James Kiley, Lauren Kunz, Mario Stylianou, Myron Maclawiw, Gail Weinmann, Laurie J. Morrison, Daniel Brodie, Charles B. Cairns, Mark N. Gillespie, Richard J. Kryscio, Daman Scales, Robert D. Truog, Polly Parsons, Jason D. Christie, Neal Dickert, Deborah Diercks, Jesse R. Hall, Nicholas J. Horton, Mitchell Levy, Mark Seigel, Ian Steill, Laurie S. Zoloth, David B. Page, Derek W. Russell, Donna S. Harris, Sheetal Gandotra
Journal: JAMA (2024)

Acetaminophen (paracetamol) has many pharmacological effects that might be beneficial in sepsis, including inhibition of cell-free hemoglobin-induced oxidation of lipids and other substrates.