tbuckley/cabot-search huggingface dataset:
Ableist Language in NIH’s Mission Statement—Reply
Authors: Lisa I. Iezzoni, Bonnielin K. Swenor
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exploring the Link Between Thyrotoxicosis and Cognitive Decline in Older Adults
Authors: Tieh-Cheng Fu, Chun-Pai Yang, Ching-Mao Chang
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Can I share my political views online?
Authors: Abi Rimmer
Journal: BMJ (2024)

While social media may seem like a place for sharing personal feelings rather than professional opinions, doctors must remain aware of how they could be perceived, Abi Rimmer hears Abi Rimmer Your behaviour mattersEmma Davies, medicolegal consultant at the Medical Protection Society, says, "Given the conflicts around the world and the pressures on the NHS, it's expected that we'll have our own opinions on these emotive matters.Social media are ever changing and fast growing, and they've been the downfall of some high profile people.Doctors may not be 'high profile' but in my experience they too are exposed to personal and professional risk from expressing strongly held views on social media.
Thrombosis risk in single- and double-heterozygous carriers of factor V Leiden and prothrombin G20210A in FinnGen and the UK Biobank
Authors: Justine Ryu, Joel T. Rämö, Sean J. Jurgens, Teemu Niiranen, Simone Sanna-Cherchi, Kenneth A. Bauer, Amelia Haj, Seung Hoan Choi, Aarno Palotie, Mark Daly, Patrick T. Ellinor, Pavan K. Bendapudi
Journal: Blood (2024)
SGLT2 Inhibitor–Associated Ketoacidosis vs Type 1 Diabetes–Associated Ketoacidosis
Authors: Mahesh M. Umapathysivam, Bethany Morgan, Joshua M. Inglis, Emily Meyer, Danny Liew, Venkatesan Thiruvenkatarajan, David Jesudason
Journal: JAMA Network Open (2024)

This cohort study examines the natural history and response to treatment of sodium glucose cotransporter 2 (SGLT2) inhibitor–associated ketoacidosis compared with that of type 1 diabetes–associated ketoacidosis.
Differences in Care Team Response to Patient Portal Messages by Patient Race and Ethnicity
Authors: Mitchell Tang, Rebecca G. Mishuris, Lily Payvandi, Ariel D. Stern
Journal: JAMA Network Open (2024)

Importance The COVID-19 pandemic was associated with substantial growth in patient portal messaging. Higher message volumes have largely persisted, reflecting a new normal. Prior work has documented lower message use by patients who belong to minoritized racial and ethnic groups, but research has not examined differences in care team response to messages. Both have substantial ramifications on resource allocation and care access under a new care paradigm with portal messaging as a central channel for patient–care team communication. Objective To examine differences in how care teams respond to patient portal messages sent by patients from different racial and ethnic groups. Design, Setting, and Participants In a cross-sectional design in a large safety-net health system, response outcomes from medical advice message threads sent from January 1, 2021, through November 24, 2021, from Asian, Black, Hispanic, and White patients were compared, controlling for patient and message thread characteristics. Asian, Black, Hispanic, and White patients with 1 or more adult primary care visits at Boston Medical Center in calendar year 2020 were included. Data analysis was conducted from June 23, 2022, through December 21, 2023. Exposure Patient race and ethnicity. Main Outcomes and Measures Rates at which medical advice request messages were responded to by care teams and the types of health care professionals that responded. Results A total of 39 043 patients were included in the sample: 2006 were Asian, 21 600 were Black, 7185 were Hispanic, and 8252 were White. A total of 22 744 (58.3%) patients were women and mean (SD) age was 50.4 (16.7) years. In 2021, these patients initiated 57 704 medical advice request message threads. When patients who belong to minoritized racial and ethnic groups sent these messages, the likelihood of receiving any care team response was similar, but the types of health care professionals that responded differed. Black patients were 3.95 percentage points (pp) less likely (95% CI, −5.34 to −2.57 pp; P &amp;amp;lt; .001) to receive a response from an attending physician, and 3.01 pp more likely (95% CI, 1.76-4.27 pp; P &amp;amp;lt; .001) to receive a response from a registered nurse, corresponding to a 17.4% lower attending response rate. Similar, but smaller, differences were observed for Asian and Hispanic patients. Conclusions and Relevance The findings of this study suggest lower prioritization of patients who belong to minoritized racial and ethnic groups during triaging. Understanding and addressing these disparities will be important for improving care equity and informing health care delivery support algorithms.
Discussion on the Application of Rapid Immunoblot Assay for AQP4-IgG Detection—Reply
Authors: Yaping Yan, Wei Qiu
Journal: JAMA Neurology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Childhood Overweight and Obesity During and After the COVID-19 Pandemic
Authors: Anna Fäldt, Sahar Nejat, Natalie Durbeej, Anton Holmgren
Journal: JAMA Pediatrics (2024)

This cohort study analyzes the prevalence of overweight and obesity among preschool children in Sweden before, during, and after the COVID-19 pandemic and longitudinal trends in body mass index.
Exploring the Link Between Thyrotoxicosis and Cognitive Decline in Older Adults—Reply
Authors: Roy Adams, Jennifer S. Mammen
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Improving Women’s Health Across the Life Span—<i>JAMA Internal Medicine</i> Call for Papers
Authors: Deborah Grady, Heather Gwynn Allore, Giselle Corbie, Kenneth E. Covinsky, Raegan W. Durant, Ishani Ganguli, Cary P. Gross, Mitchell H. Katz, Lona Mody, Tracy Wang, Yorghos Tripodis, Sharon K. Inouye
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1β–mediated AML progression
Authors: Hsin-Yun Lin, Mona Mohammadhosseini, John McClatchy, Marina Villamor-Payà, Sophia Jeng, Daniel Bottomly, Chia-Feng Tsai, Camilo Posso, Jeremy Jacobson, Andrew Adey, Sara Gosline, Tao Liu, Shannon McWeeney, Travis H. Stracker, Anupriya Agarwal
Journal: Blood (2024)
Transition to Weight-Based High-Flow Nasal Cannula Use Outside of the ICU for Bronchiolitis
Authors: Robert J. Willer, Patrick W. Brady, Amy N. Tyler, Jennifer D. Treasure, Eric R. Coon
Journal: JAMA Network Open (2024)

Importance Most children’s hospitals have adopted weight-based high-flow nasal cannula (HFNC) bronchiolitis protocols for use outside of the intensive care unit (ICU) setting. Whether these protocols are achieving their goal of reducing bronchiolitis-related ICU admissions remains unknown. Objective To measure the association between hospital transition to weight-based non-ICU HFNC use and subsequent ICU admission. Design, Setting, and Participants This multicenter retrospective cohort study was conducted with a controlled interrupted time series approach and involved 18 children’s hospitals that contribute data to the Pediatric Health Information Systems database. The cohort included patients aged 0 to 24 months who were hospitalized with a diagnosis of bronchiolitis between January 1, 2010, and December 31, 2021. Data were analyzed from July 2023 to January 2024. Exposure Hospital-level transition from ICU-only to weight-based non-ICU protocol for HFNC use. Data for the ICU-only group were obtained from a previously published survey. Main Outcomes and Measures Proportion of patients with bronchiolitis admitted to the ICU. Results A total of 86 046 patients with bronchiolitis received care from 10 hospitals in the ICU-only group (n = 47 336; 27 850 males [58.8%]; mean [SD] age, 7.6 [6.2] years) and 8 hospitals in the weight-based protocol group (n = 38 710; 22 845 males [59.0%]; mean [SD] age, 7.7 [6.3] years). Mean age and sex were similar for patients between the 2 groups. Hospitals in the ICU-only group vs the weight-based protocol group had higher proportions of Black (26.2% vs 19.8%) and non-Hispanic (81.6% vs 63.8%) patients and patients with governmental insurance (68.1% vs 65.9%). Hospital transition to a weight-based HFNC protocol was associated with a 6.1% (95% CI, 8.7%-3.4%) decrease per year in ICU admission and a 1.5% (95% CI, 2.8%-0.1%) reduction per year in noninvasive positive pressure ventilation use compared with the ICU-only group. No differences in mean length of stay or the proportion of patients who received invasive mechanical ventilation were found between groups. Conclusions and Relevance Results of this cohort study of hospitalized patients with bronchiolitis suggest that transition from ICU-only to weight-based non-ICU HFNC protocols is associated with reduced ICU admission rates.
Tantalum Particles Promote M2 Macrophage Polarization and Regulate Local Bone Metabolism via Macrophage‐Derived Exosomes Influencing the Fates of BMSCs
Authors: Junjun Yang, Xiaoyuan Gong, Tao Li, Zengzilu Xia, Rui He, Xiongbo Song, Xin Wang, Jiangyi Wu, Jiajia Chen, Fangzheng Wang, Ran Xiong, Yangjing Lin, Guangxing Chen, Liu Yang, Kaiyong Cai
Journal: Advanced Healthcare Materials (2024)

In this study, the regulatory role and mechanisms of tantalum (Ta) particles in the bone tissue microenvironment are explored. Ta particle deposition occurs in both clinical samples and animal tissues following porous Ta implantation. Unlike titanium (Ti) particles promoting M1 macrophage (Mϕ) polarization, Ta particles regulating calcium signaling pathways and promoting M2 Mϕ polarization. Ta-induced M2 Mϕ enhances bone marrow-derived mesenchymal stem cells (BMSCs) proliferation, migration, and osteogenic differentiation through exosomes (Exo) by upregulating miR-378a-3p/miR-221-5p and downregulating miR-155-5p/miR-212-5p. Ta particles suppress the pro-inflammatory and bone resorption effects of Ti particles in vivo and in vitro. In a rat femoral condyle bone defect model, artificial bone loaded with Ta particles promotes endogenous Mϕ polarization toward M2 differentiation at the defect site, accelerating bone repair. In conclusion, Ta particles modulate Mϕ polarization toward M2 and influence BMSCs osteogenic capacity through Exo secreted by M2 Mϕ, providing insights for potential bone repair applications.
Minimally invasive robot-assisted and laparoscopic distal pancreatectomy in a pan-European registry a retrospective cohort study
Authors: Eduard A. van Bodegraven, Tess M. E. van Ramshorst, Svein O. Bratlie, Arto Kokkola, Ernesto Sparrelid, Bergthor Björnsson, Dyre Kleive, Stefan K. Burgdorf, Safi Dokmak, Bas Groot Koerkamp, Santiago Sánchez Cabús, I Quintus Molenaar, Ugo Boggi, Olivier R. Busch, Miha Petrič, Geert Roeyen, Thilo Hackert, Daan J. Lips, Mathieu D’Hondt, Mariëlle M E Coolsen, Giovanni Ferrari, Bobby Tingstedt, Alejandro Serrablo, Sebastien Gaujoux, Marco Ramera, Igor Khatkov, Fabio Ausania, Regis Souche, Sebastiaan Festen, Frederik Berrevoet, Tobias Keck, Robert P. Sutcliffe, Elizabeth Pando, Roeland F. de Wilde, Beatrice Aussilhou, Paul S. Krohn, Bjørn Edwin, Per Sandström, Stefan Gilg, Hanna Seppänen, Caroline Vilhav, Mohammad Abu Hilal, Marc G. Besselink
Journal: International Journal of Surgery (2024)

International guidelines recommend monitoring the use and outcome of minimally invasive pancreatic surgery (MIPS). However, data from prospective international audits on minimally invasive distal pancreatectomy (MIDP) are lacking. This study examined the use and outcome of robot-assisted (RDP) and laparoscopic (LDP) distal pancreatectomy in the E-MIPS registry.
Effect of clinical decision support for severe hypercholesterolemia on low-density lipoprotein cholesterol levels
Authors: Hana Bangash, Seyedmohammad Saadatagah, Mohammadreza Naderian, Marwan E. Hamed, Lubna Alhalabi, Alborz Sherafati, Joseph Sutton, Omar Elsekaily, Ali Mir, Justin H. Gundelach, Daniel Gibbons, Paul Johnsen, Christina M. Wood-Wentz, Carin Y. Smith, Pedro J. Caraballo, Kent R. Bailey, Iftikhar J. Kullo
Journal: npj Digital Medicine (2024)

Abstract Severe hypercholesterolemia/possible familial hypercholesterolemia (FH) is relatively common but underdiagnosed and undertreated. We investigated whether implementing clinical decision support (CDS) was associated with lower low-density lipoprotein cholesterol (LDL-C) in patients with severe hypercholesterolemia/possible FH (LDL-C ≥ 190 mg/dL). As part of a pre-post implementation study, a CDS alert was deployed in the electronic health record (EHR) in a large health system comprising 3 main sites, 16 hospitals and 53 clinics. Data were collected for 3 months before (‘silent mode’) and after (‘active mode’) its implementation. Clinicians were only able to view the alert in the EHR during active mode. We matched individuals 1:1 in both modes, based on age, sex, and baseline lipid lowering therapy (LLT). The primary outcome was difference in LDL-C between the two groups and the secondary outcome was initiation/intensification of LLT after alert trigger. We identified 800 matched patients in each mode (mean ± SD age 56.1 ± 11.8 y vs. 55.9 ± 11.8 y; 36.0% male in both groups; mean ± SD initial LDL-C 211.3 ± 27.4 mg/dL vs. 209.8 ± 23.9 mg/dL; 11.2% on LLT at baseline in each group). LDL-C levels were 6.6 mg/dL lower (95% CI, −10.7 to −2.5; P = 0.002) in active vs. silent mode. The odds of high-intensity statin use (OR, 1.78; 95% CI, 1.41–2.23; P &lt; 0.001) and LLT initiation/intensification (OR, 1.30, 95% CI, 1.06–1.58, P = 0.01) were higher in active vs. silent mode. Implementation of a CDS was associated with lowering of LDL-C levels in patients with severe hypercholesterolemia/possible FH, likely due to higher rates of clinician led LLT initiation/intensification.
Neurological Illness and National Security
Authors: David A. Relman
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical, Biomarker, and Research Tests Among US Government Personnel and Their Family Members Involved in Anomalous Health Incidents
Authors: Leighton Chan, Mark Hallett, Chris K. Zalewski, Carmen C. Brewer, Cris Zampieri, Michael Hoa, Sara M. Lippa, Edmond Fitzgibbon, Louis M. French, Anita D. Moses, André J. van der Merwe, Carlo Pierpaoli, L. Christine Turtzo, Simge Yonter, Pashtun Shahim, Brian Moore, Lauren Stamps, Spencer Flynn, Julia Fontana, Swathi Tata, Jessica Lo, Mirella A. Fernandez, Annie-Lori Joseph, Jesse Matsubara, Julie Goldberg, Thuy-Tien D. Nguyen, Noa Sasson, Justine Lely, Bryan Smith, Kelly A. King, Jennifer Chisholm, Julie Christensen, M. Teresa Magone, Chantal Cousineau-Krieger, Rakibul Hafiz, Amritha Nayak, Okan Irfanoglu, Sanaz Attaripour, Chen Lai, Wendy B. Smith
Journal: JAMA (2024)

Since 2015, US government and related personnel have reported dizziness, pain, visual problems, and cognitive dysfunction after experiencing intrusive sounds and head pressure. The US government has labeled these anomalous health incidents (AHIs).
Neuroimaging Findings in US Government Personnel and Their Family Members Involved in Anomalous Health Incidents
Authors: Carlo Pierpaoli, Amritha Nayak, Rakibul Hafiz, M. Okan Irfanoglu, Gang Chen, Paul Taylor, Mark Hallett, Michael Hoa, Dzung Pham, Yi-Yu Chou, Anita D. Moses, André J. van der Merwe, Sara M. Lippa, Carmen C. Brewer, Chris K. Zalewski, Cris Zampieri, L. Christine Turtzo, Pashtun Shahim, Leighton Chan, Brian Moore, Lauren Stamps, Spencer Flynn, Julia Fontana, Swathi Tata, Jessica Lo, Mirella A. Fernandez, Annie Lori-Joseph, Jesse Matsubara, Julie Goldberg, Thuy-Tien D. Nguyen, Noa Sasson, Justine Lely, Bryan Smith, Kelly A. King, Jennifer Chisholm, Julie Christensen, M. Teresa Magone, Chantal Cousineau-Krieger, Louis M. French, Simge Yonter, Sanaz Attaripour, Chen Lai
Journal: JAMA (2024)

US government personnel stationed internationally have reported anomalous health incidents (AHIs), with some individuals experiencing persistent debilitating symptoms.
177Lu-DOTATATE Salvage Therapy in Rapidly Progressing Neuroendocrine Tumor With Poor Performance Status
Authors: Piyush Aggarwal, Ajay Kumar, Ashwani Sood, Rama Walia, Sanjay Kumar Bhadada, Bhagwant Rai Mittal
Journal: Clinical Nuclear Medicine (2024)

Abstract Peptide receptor radionuclide therapy (PRRT) has shown to be effective and safe in metastatic gastroenteropancreatic and nongastroenteropancreatic neuroendocrine tumors. However, the selection criteria for PRRT are restricted to patients with good performance status (Eastern Cooperative Oncology Group score ≤2 or Karnofsky performance score ≥60). This denies many patients with adequate somatostatin receptor expression and biochemical profiles from the beneficial effects of PRRT on the quality of life, daily function, and overall survival. The 2 cases highlight the favorable response of PRRT in patients with metastatic neuroendocrine tumor having a very poor performance status initially.