tbuckley/cabot-search huggingface dataset:
Hypertension Risk and Kidney Function Following Kidney Donation
Authors: Ping Zhong, Xin Liu, Limin Liao
Journal: JAMA (2024)

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Salt and Atopic Dermatitis
Authors: Yi-Cheng Lin, Chia-Hao Hsu
Journal: JAMA Dermatology (2024)

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Massage
Authors: Woods Nash
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Measurement Properties of the Patient Health Questionnaire–15 and Somatic Symptom Scale–8
Authors: Jonna Hybelius, Amanda Kosic, Sigrid Salomonsson, Caroline Wachtler, John Wallert, Steven Nordin, Erland Axelsson
Journal: JAMA Network Open (2024)

Importance The subjective experience of somatic symptoms is a key concern throughout the health care system. Valid and clinically useful instruments are needed. Objective To evaluate the measurement properties of 2 widespread patient-reported outcomes: the Patient Health Questionnaire–15 (PHQ-15) and Somatic Symptom Scale–8 (SSS-8). Data Sources Medline, PsycINFO, and Web of Science were last searched February 1, 2024. Study Selection English-language studies reporting estimates pertaining to factor analysis, taxometric analysis, internal consistency, construct validity, mean scores in relevant groups, cutoffs, areas under the receiver operating characteristic curves (AUROCs), minimal clinically important difference, test-retest reliability, or sensitivity to change. Data Extraction and Synthesis Search hits were reviewed by independent raters. Cronbach α, Pearson r , means, and between-group effect sizes indicative of sensitivity to change were pooled in random-effects meta-analysis. Study quality was assessed using 3 instruments. Reporting followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 reporting guideline. Main Outcomes and Measures Comprehensive overview of evidence pertaining to the measurement properties of the PHQ-15 and SSS-8. Results A total of 305 studies with 361 243 participants were included. Most concerned routine care (178 studies) and the general population (27 studies). In factor analyses, both scales reflected a combination of domain-specific factors (cardiopulmonary, fatigue, gastrointestinal, pain) and a general symptom burden factor. The pooled PHQ-15 α was 0.81 (95% CI, 0.80-0.82), but with low item-total correlations for items concerning menstrual problems, fainting spells, and sexual problems (item-total correlations &amp;amp;lt;0.40), and the SSS-8 α was 0.80 (0.77-0.83). Pooled correlations with other measures of somatic symptom burden were 0.71 (95% CI, 0.64-0.78) for the PHQ-15 and 0.82 (95% CI, 0.72-0.92) for the SSS-8. Reported AUROCs for identification of somatoform disorders ranged from 0.63 (95% CI, 0.50-0.76) to 0.79 (95% CI, 0.73-0.85) for the PHQ-15 and from 0.71 (95% CI, 0.66-0.77) to 0.73 (95% CI, 0.69-0.76) for the SSS-8. The minimal clinically important difference on both scales was 3 points. Test-retest reliability could not be pooled and was inconsistent for the PHQ-15 (PHQ-15: r = 0.65-0.93; ICC, 0.87; SSS-8: r = 0.996, ICC = 0.89). The PHQ-15 showed tentative sensitivity to change ( g = 0.32; 95% CI, 0.08-0.56), but data for the SSS-8 were lacking. Conclusions and Relevance In this systematic review and meta-analysis, findings supported use of the PHQ-15 and SSS-8 for the assessment of symptom burden, but users should be aware of the complex, multifactorial structures of these scales. More evidence is needed concerning longitudinal measurement properties.
Tailored Bioengineering and Nanomedicine Strategies for Sex-Specific Healing of Chronic Wounds
Authors: Negar Mahmoudi, Shahriar Sharifi, Dmitry Leshchiner, Sachi Horibata, Zijin Lin, Noor Ghazali, Mohammad-Ali Shahbazi, Ayushi Priyam, Richard J Williams, Irena Pastar, Lisa Gould, Simon Matoori, David Nisbet, Morteza Mahmoudi
Journal: British Journal of Dermatology (2024)

Abstract Chronic wounds, defined by their prolonged healing process, significantly impair patient quality of life and impose a hefty financial burden on healthcare systems worldwide. Sex/gender-specific mechanisms regulate inflammation and infection, angiogenesis, matrix synthesis, and cell recruitment contribute to cutaneous wound healing, but remain largely understudied. This review is aimed to spotlight the innovative realm of bioengineering and nanomedicine, which is at the helm of revolutionizing complex chronic wound care. It underscores the significance of integrating patient sex into the development and (pre)clinical testing of these avant-garde treatment modalities, in order to enhance healing prospects for both women and men. Moreover, we explore the representation of both sexes in clinical trials of bioengineered and nanomedicine products. Finally, we examine the primary reasons for the historical neglect in translating sex-specific wound healing research into clinical practice and propose strategic solutions. By tackling these issues, the article advocates for advanced treatment frameworks that could significantly improve healing outcomes for individuals of all sexes, thereby optimizing both efficacy and inclusivity in chronic wound management.
Outdoor Artificial Light at Night and Insomnia-Related Social Media Posts
Authors: Jiahao Duan, Qian Li, Zhouxin Yin, Shihan Zhen, Wenzhe Cao, Shiwei Yan, Yanhui Zhang, Qingyao Wu, Wei Zhang, Fengchao Liang
Journal: JAMA Network Open (2024)

Importance Understanding the outcomes of artificial light at night (ALAN) on insomnia is crucial for public health, particularly in rapidly urbanizing regions. However, evidence of the association between ALAN exposure and insomnia is limited, despite the large number of people exposed to ALAN. Objective To explore the association between outdoor ALAN exposure and insomnia among the Chinese population. Design, Setting, and Participants This cross-sectional study used social media data from Weibo (Sina), a social media platform, and satellite-derived nighttime light images. The study period spans from May 2022 to April 2023. The study encompasses 336 cities across China’s mainland, providing a comprehensive national perspective. Data include insomnia-related posts from the platform users, representing a large and diverse population sample exposed to varying levels of ALAN. Exposure Outdoor ALAN exposure (in nanowatts per centimeters squared per steradian [nW/cm 2 /sr]) was measured using satellite-derived nighttime light images at a spatial resolution of 500 m. Main Outcomes and Measures The incidence of insomnia among residents at the city level was measured by the number of insomnia-related posts on social media. Multiple linear regression models were used to estimate the association between ALAN exposure and population insomnia, adjusting for population characteristics and meteorological factors at the city level. Results The study included data from 1 147 583 insomnia-related posts. Daily mean ALAN exposure across the 336 cities ranged from 3.1 to 221.0 nW/cm 2 /sr. For each 5 nW/cm 2 /sr increase in ALAN exposure, the incidence of insomnia increased by 0.377% (95% CI, 0.372%-0.382%). The association was greater in less populated cities and under extreme temperature and poor air quality conditions. The observed exposure-response functions between ALAN exposure and insomnia demonstrated an upward trend, with steeper slopes observed at low exposures and leveling off at higher exposures. Conclusions and Relevance This study provides evidence of the association between increased ALAN exposure and higher incidence of insomnia. These findings expand the current knowledge on adverse health outcomes of ALAN exposure and emphasize the potential health benefits of well-planned artificial nighttime lighting in China and other developing countries in the early stages of city planning.
Surgery-First for Painful Chronic Pancreatitis
Authors: Ville Sallinen, Arto Kokkola, Pauli Puolakkainen
Journal: JAMA Surgery (2024)

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Salt and Atopic Dermatitis—Reply
Authors: Brenda M. Chiang, Morgan Ye, Katrina Abuabara
Journal: JAMA Dermatology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Salt and Atopic Dermatitis
Authors: Ian A. Myles, Jeffrey B. Kopp
Journal: JAMA Dermatology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Hypertension Risk and Kidney Function Following Kidney Donation—Reply
Authors: Amit X. Garg, Meaghan S. Cuerden, Jessica M. Sontrop
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trends in Postpartum Depression by Race, Ethnicity, and Prepregnancy Body Mass Index
Authors: Nehaa Khadka, Michael J. Fassett, Yinka Oyelese, Nana A. Mensah, Vicki Y. Chiu, Meiyu Yeh, Morgan R. Peltier, Darios Getahun
Journal: JAMA Network Open (2024)

Importance Postpartum depression (PPD) poses significant risks to maternal and child health. Understanding temporal trends is crucial for evaluating prevalence and identifying populations at risk. Objective To evaluate recent trends in PPD and assess how these trends are associated with race, ethnicity, and prepregnancy body mass index (BMI). Design, Setting, and Participants A serial, cross-sectional analysis using data from the Kaiser Permanente Southern California (KPSC) electronic health records (EHRs), with live and stillbirths at 20 or more weeks of gestation who were KPSC members at the time of delivery between 2010 and 2021. Data were analyzed from July 2022 to August 2023. Exposures Self-reported race, ethnicity, and recorded prepregnancy BMI. Main outcome measures PPD cases were identified using validated diagnostic codes and prescription records within 12 months postpartum in the KPSC EHRs. Patients with an Edinburgh Postnatal Depression Scale score of 10 or more within 6 months postpartum were further evaluated by a mental health specialist for formal PPD diagnosis. Results In this study of 442 308 pregnancies, the median (IQR) maternal age at delivery was 31 (27-34) years. The cohort was racially and ethnically diverse, with 62 860 individuals (14.2%) identifying as Asian/Pacific Islander, 231 837 (52.4%) as Hispanic, 33 207 (7.5%) as non-Hispanic Black, 108 201 (24.5%) as non-Hispanic White, 5903 (1.3%) as multiple or other, and 300 (0.1%) unknown. PPD prevalence doubled over the study period, increasing from 9.4% in 2010 to 19.0% in 2021. The largest increases were observed among Asian and Pacific Islander participants (280% increase) and non-Hispanic Black participants (140% increase). PPD rates increased across all BMI categories, particularly among individuals with obesity (class I) and morbid obesity (class II/III). Conclusions and Relevance In this cross-sectional study, PPD diagnosis increased significantly across all racial and ethnic groups and BMI categories over the past decade. While rising PPD may reflect improved screening and diagnosis practices, the persistently high rates highlight the need to develop and implement interventions to prevent the condition while expanding efforts to mitigate the impact of PPD on maternal and child health.
Bioengineering on the Front Lines
Authors: Britt H. Tonnessen, Alan Dardik
Journal: JAMA Surgery (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Cancer Mortality in Louisiana’s Correctional System, 2015-2021
Authors: Totadri Dhimal, Paula Cupertino, Zijing Cheng, Erika E. Ramsdale, Bailey K. Hilty Chu, Brian J. Kaplan, Andrea Armstrong, Xueya Cai, Yue Li, Fergal J. Fleming, Anthony Loria
Journal: JAMA Network Open (2024)

This cohort study evaluates cancer-specific mortality data about incarcerated individuals in Louisiana to examine why gaps in cause-specific data exist for this group.
Ensuring Virtual Vigilance in Decentralized Clinical Trials
Authors: Adrian F. Hernandez, Christopher J. Lindsell
Journal: JAMA (2024)

This Viewpoint discusses the increased use of decentralized clinical trials (DCTs) to improve efficiency in health research, highlights a number of risks to research rigor inherent in DCTs, and suggests ways in which DCT designers can better frame trial monitoring and oversight to ensure data integrity and avoid health inequities.
American College of Surgeons Operative Standards and Breast Cancer Outcomes
Authors: Crystal D. Taylor, Ton Wang, Alison S. Baskin, Brandy Sinco, Tasha M. Hughes, Daniel J. Boffa, Judy C. Boughey, Lesly A. Dossett
Journal: JAMA Network Open (2024)

Importance The American College of Surgeons (ACS) operative standards were established to detail critical elements of cancer surgery, reduce technical variation, and improve outcomes. Two of the 6 operative standards target adequate axillary surgery for breast cancer. The potential association of the operative standards with short-term oncologic outcomes, such as nodal yield and nodal positivity rates, is currently unknown. Objective To evaluate the potential association of the ACS operative standards with short-term oncologic outcomes in breast cancer. Design, Setting, and Participants A cohort study was performed using data on 1 201 317 women 18 years or older who underwent sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND) for invasive breast cancer from January 1, 2012, to December 31, 2020. Patients were identified using the National Cancer Database (NCDB), a clinical oncology database encompassing approximately 70% of new cancer diagnoses, sourced from hospital registry data from 1317 facilities. Statistical analysis was performed from October 2023 to June 2024. Exposure Sentinel lymph node biopsy or ALND. Main Outcomes and Measures Reliability-adjusted facility-level lymph node yield and nodal positivity rate for each procedure were calculated using generalized linear mixed models, Poisson regression, and logistic regression with facility-level random intercepts. Results The cohort included 1 201 317 women with a median age of 62 years (IQR, 53-70 years). Facility-level nodal yield ranged from 1 to 6 for SLNB and from 6 to 22 for ALND. Median facility-level nodal yield for SLNB was 2.6 (IQR, 2.3-3.0) and the nodal positivity rate for SLNB was 12.2% (IQR, 11.0%-13.7%), with rates ranging from 6% to 21%. A weak correlation between facility-level lymph node yield and nodal positivity was observed (Spearman correlation coefficient, 0.17). Median nodal upstaging rate (≥4 positive nodes) for ALND was 30.5% (IQR, 26.5%-35.0%), with rates ranging from 11% to 54%; median nodal yield was 12.2 (IQR, 10.9-13.6). A strong correlation between nodal yield and nodal upstaging rates was observed (Spearman correlation coefficient, 0.53). Conclusions and Relevance In this cohort study of women undergoing axillary surgery for invasive breast cancer, facility-level variation in lymph node yield was present for both SLNB and ALND, which could potentially be improved through the ACS operative standards. However, this variation had mixed associations with nodal positivity and upstaging rates, suggesting the association of the ACS operative standards with oncologic outcomes may be mixed.