tbuckley/cabot-search huggingface dataset:
Evaluating end of life care: The Quality Oncology Practice Initiative (QOPI) experience
Authors: M. N. Neuss, J. O. Jacobson, C. Earle, C. E. Desch, K. McNiff, L. Thacker, J. V. Simone
Journal: Journal of Clinical Oncology (2006)

8573 Background: Little is known about the quality of end-of-life (EOL) care provided to cancer patients, with data largely available only from administrative databases. QOPI is a practice-based system of quality self-assessment now available to any ASCO physician wishing to participate. QOPI methodology allows comparison of EOL care among practices and provides a basis for self-improvement. Methods: In Summer 2005, during the pilot phase of QOPI, several EOL questions were included in the survey instrument. Practices were requested to review the records of at least 15 patients who had died. Practice members performed standardized chart abstractions and data were entered directly on to a secure web-based application. A total of 455 charts were abstracted from 22 practices. Results: See table. Conclusion : QOPI provides an effective mechanism for collecting practice-specific EOL data. Aggregate data from the 22 QOPI pilot practices demonstrate a high level of performance compared with results reported from population-based studies. Significant variation among practices is present, representing an opportunity to improve the EOL care of cancer patients. [Table: see text] No significant financial relationships to disclose.
What a Young Husband Ought to Know.
Authors: Sylvanus Stall
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of serial serum IL-6 levels in women with newly diagnosed ovarian cancer on a prospective clinical trial
Authors: J. Mahoney, H. Lee, R. Foster, U. Matulonis, Z. Duan, M. V. Seiden
Journal: Journal of Clinical Oncology (2006)

5065 Background: Elevated levels of IL-6 in serum have been reported in patients (pts) with mullerian malignancies (MM) and have been associated with a poor prognosis. Little is know about the behavior of IL-6 during effective cytotoxic therapy and its correlation to various clinical parameters. Methods: Pts with surgically debulked FIGO Stage II, III, and IV MM were enrolled in the Modified Triple Doublets trial. 83 pts were assigned to a cohort in accordance with the extent of surgical debulking. Cohort I included women who had been optimally cytoreduced to &lt;1cm of residual tumor. Cohort II consisted of pts who had either post-debulking residual disease &gt;1cm or stage IV disease. Both cohorts were treated with 3 sequential chemotherapy doublets, gemcitabine/carboplatin, paclitaxel/carboplatin, and adriamycin/topotecan. Each doublet was delivered for 3 cycles. Serum was collected from pts prior to initiating each doublet at cycles 1, 4, 7 and at the end of study (post cycle 9). Serum IL-6 levels were measured in triplicate by sandwich ELISA. Results: Pts with MM had elevated levels of IL-6 following debulking surgery (mean = 12.7 pg/ml) as compared to normal controls (n = 11, mean IL-6 = 1.5 pg/ml, p =.01). While there was no significant correlation between IL-6 levels and stage of disease, the IL-6 serum concentrations did correlate with extent of surgical debulking (p = 0.0182). IL-6 concentrations dropped throughout all cycles of platinum based treatment with post platinum treatment mean concentration of 3.9pg/ml. IL-6 levels did not correlate with outcome of second look operation and there was no statistically significant correlation between IL-6 and CA-125 levels (p = 0.1612). Survival data is still immature with a median follow-up of 34 months, yet elevation of IL-6 levels following surgery demonstrates a trend towards inferior survival. Conclusions: IL-6 levels are elevated in ovarian cancer pts following surgical debulking and correlate with the volume of residual disease following surgical cytoreduction. Values decrease during cytoreductive platinum based chemotherapy although IL-6 was not as predictive of response as was CA-125. Data demonstrates a weak correlation betweenworse survival and elevated IL-6 levels. Supported by the Lana Vento Foundation. No significant financial relationships to disclose.
Sheffield NHS trust and council pay 27 000 in damages after failing to agree patient's care budget
Authors: C. Dyer
Journal: BMJ (2015)

A vulnerable woman who had both legs amputated and was left for more than 14 months without funds to pay for her care package because of a dispute between the NHS and social services is to receive £27 000 in compensation.1 2

The parliamentary and health service ombudsman and the local government ombudsman jointly recommended that Sheffield City Council and Sheffield Health and Social Care NHS Foundation Trust, a mental health trust, pay compensation to the unnamed woman, referred to as “Ms D.”

Ms D, who has …
Monocytes, Monocytosis and Monocytic Leukemia.
Authors: Lawrence Kass, Bertram Schnitzer
Journal: Annals of Internal Medicine (1974)

Monocytes, monocytosis, and monocytic leukemia , Monocytes, monocytosis, and monocytic leukemia , کتابخانه مرکزی دانشگاه علوم پزشکی ایران
Abstract 11500: Increased Washout of 99mTc-Sestamibi Would Reflect Impaired Myocardial Contractile and Relaxation Reserve During Dobutamine Stress Due to Mitochondrial Dysfunction in Dilated Cardiomyopathy Patients
Authors: Daisuke Hayashi, Satoru Ohshima, Satoshi Isobe, Cheng Xianwu, Norihiro Shinoda, Takahiro Okumura, Akihiro Hirashiki, Kazumasa Unno, Toyoaki Murohara
Journal: Circulation (2011)

Introduction Myocardial mitochondrial damage reduces ATP production, and causes myocardial dysfunction. Increased 99mTc-sestamibi (Tc-99m-MIBI) myocardial washout is reportedly caused by mitochondrial dysfunction. We therefore investigated whether Tc-99m-MIBI washout rate (WR) would predict the mitochondrial damage and myocardial dysfunction in dilated cardiomyopathy (DCM) patients.

Methods Twenty-one DCM patients (NYHA I to III) underwent Tc-99m-MIBI myocardial scintigraphy and cardiac catheterization. Myocardial Tc-99m-MIBI uptake was quantified as early heart-mediadtinum ratio (H/M) and delayed H/M, and WR was calculated. Endomyocardial biopsy specimens were obtained for quantitative mRNA analysis and electron microscopy. LV dP/dtmax (index of myocardial contractility) and T1/2 (index of myocardial relaxation) were calculated by left ventricular pressure curve at baseline and during dobutamine infusion (15 μg/kg/min). The patients were divided into two groups as follows: group A of 10 patients showing WR ≥ 24.44%; group B of 11 patients showing WR ≥ 24.44%.

Results The abundance of mRNAs for mitochondrial electron transport-related enzymes (α-KGDH, NDUFV3, COX5B) were significantly higher in group A than in group B. Electron microscopy showed that a percentage of damaged mitochondria, glycogen droplet, and lipid droplets were much greater in group B than in group A. WR of Tc-99m-MIBI were significantly correlated with the percentage change in LV dP/dtmax(%LV dP/dtmax) (r=0.49, P=0.02) and T1/2(%T1/2) (r=0.34, P=0.04) from baseline to dobutamine stress. No significant correlation was seen between early or delayed H/M and %LV dP/dtmax or %T1/2. %LV dP/dtmax in group B was significant larger than that in group A.

Conclusions Increased washout rate of Tc-99m-MIBI could predict the mitochondrial dysfunction and the impairment of myocardial contractile and relaxation reserves during dobutamine stress test in DCM patients noninvasively.

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Management of Esophageal Disease.
Authors: David B. Skinner, R. H. R. Belsey
Journal: Annals of Internal Medicine (1972)

A comprehensive and cohesive text on the treatment of esophageal problems, including endoscopic management. It details all aspects, including normal anatomy and physiology, assessment of the disease, pathology, and principles of both medical and surgical treatment. All major problems are explored with in-depth management plans provided.
Early detection of breast cancer
Authors: A Mariscal Martínez
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In the Council on Scientific Affairs' report that appeared in the Dec 7 issue ofThe Journal,<sup>1</sup>the statement was made in reference to aspirated cyst fluid that "the fluid itself should be sent for cytopathologic examination to exclude an intracystic cancer." I think that many, if not the great majority of, surgeons and pathologists would disagree; in fact, Devitt and Barr<sup>2</sup>recently referred to the cytological examination of aspirated cyst fluid as fruitless. In their review of seven cases of cystic breast malignant disorders, they noted that the diagnosis could be made in every instance by clinical means, ie, the presence of a residual or recurrent mass after aspiration and the nature of the fluid (bloody or peculiar). Cytology was performed in five of the seven patients whose cystic lesion were aspirated, with negative results found in three, suspicious findings in one, and a
Butterworths Medico-Legal Encyclopaedia.
Authors: J. K. Mason, R. A. McCall Smith
Journal: Annals of Internal Medicine (1988)

Drawing on their extensive knowledge of this area, the authors have selected topics from across the field of legal medicine to compile a comprehensive encyclopedia of over 600 entries, each giving a clear, readable, but concise account of its topic. The explanations should be easily understood by practitioners of both disciplines and, as an aid to further study, extensive reference is made to additional reading material and to relevant legal cases. The legal emphasis is primarily on British law, but reference is made to Commonwealth, EEC and US legislation where this indicates a trend likely to be followed by the UK. Interest in many issues in the medico-legal field has grown rapidly in recent years and this book should prove an invaluable reference to all those practising in, or associated with, the legal and medical fields.
CLINICAL EVIDENCE OF SENSITIVITY TO GONADOTROPINS IN ALLERGIC WOMEN
Authors: E W PHILLIPS
Journal: Annals of Internal Medicine (1949)

Article1 February 1949CLINICAL EVIDENCE OF SENSITIVITY TO GONADOTROPINS IN ALLERGIC WOMENE. W. PHILLIPS, M.D., F.A.C.P.E. W. PHILLIPS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-2-364 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe concept that women may become sensitized to the hormones secreted by their own endocrine glands has occurred to a number of observers widely separated in time, place and viewpoint. For example, Finch1in 1938, and later (1940), published his finding that the nausea and vomiting of early pregnancy are allergic in origin and that they can be relieved by desensitization with a hormone derived from corpus luteum. My earlier reports on sensitivity to gonadotropins,2and on the technic of testing and the results of treatment with a preparation of gonadotropins,3appeared in 1942 and 1943. Zondek and Bromberg,4writing...Bibliography1. FINCH JW: Etiology of nausea and vomiting of pregnancy, Jr. Am. Med. Assoc., 1938, cxi, 1368-1370. Nausea and vomiting of pregnancy due to allergic reaction, Am. Jr. Obst., and Gynec., 1940, xl, 1029. CrossrefGoogle Scholar2. PHILLIPS EW: Allergic shock caused by Synapoidin, Am. Jr. Obst., and Gynec., 1942, xliv, 706-708. CrossrefGoogle Scholar3. PHILLIPS EW: Relief of allergic premenstrual headache, Southwest. Med., 1943, June, 144-147. Google Scholar4. ZONDEKBROMBERG BYM: Endocrine allergy, Jr. Allerg., 1945, xvi, 1-16. CrossrefGoogle Scholar5. FREED SC: Treatment of premenstrual distress, Jr. Am. Med. Assoc., 1945, cxxvii, 377-379. CrossrefGoogle Scholar6. WALDBOTT GL: Is there an intrinsic asthma? Ann. Int. Med., 1947, xxvi, 863-372. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 2, 1947. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAutoimmune Progesterone DermatitisAutoimmune progesterone dermatitis and its manifestation as anaphylaxis: a case report and literature reviewULCERATIVE STOMATITIS CAUSED BY ENDOGENOUS PROGESTERONE*HERBERT BERGER, M.D., F.A.C.P.Endocrine allergy and the therapeutic use of pregnandiol 1 February 1949Volume 30, Issue 2Page: 364-373KeywordsEndocrine physiologyGonadotropinsHormonesNauseaPregnancyVomiting ePublished: 1 December 2008 Issue Published: 1 February 1949 PDF downloadLoading ...
USP2a is an oncogenic isopeptidase and a potential target in prostate cancer
Authors: C. Priolo, D. Tang, M. Brahmandam, B. Benassi, E. Sicinska, S. Ogino, A. Farsetti, A. Porrello, P. G. Febbo, J. Zimmermann, M. F. Loda
Journal: Journal of Clinical Oncology (2006)

14522 Background: De-ubiquitinating enzymes (isopeptidases) remove ubiquitin side chains prior to degradation by the proteosome thus stabilizing their protein targets. We have identified a novel androgen regulated isopeptidase, USP2a, and demonstrated that it binds and prolongs the half-life of fatty acid synthase (FAS), a key enzyme in lipid metabolism of tumor cells. Methods: We determined whether USP2a has oncogenic properties in vitro and in vivo. Wild-type and catalytically inactive USP2a were introduced in immortalized normal prostate epithelial cells (AR-iPrECs). Clonogenicity assays and apoptosis induction by chemotherapeutic agents were performed on these cells. Anti-USP2a siRNA were transfected in normal and transformed (LNCaP, DU145 and PC-3) prostate cell lines. Oncogenicity in vivo was shown by s.c. injection of NIH3T3-USP2a cells in nude mice. Furthermore, USP2a mRNA expression and gene microarrays were tested in 52 human prostate adenocarcinomas. Results: Wild-type USP2a overexpression in AR-iPrEC cells resulted in a significant increase in number and size of colonies compared to those obtained in parental cells. Growth in soft agar was significantly enhanced as well. Silencing of USP2a in LNCAP and DU145 cells resulted in a strong apoptotic effect, evaluated by FACS analysis and cleaved-PARP expression. The role of this isopeptidase in apoptosis regulation was confirmed on AR-iPrEC-USP2a cells, that showed resistance to apoptosis induced by cisplatin and taxol. Importantly, USP2a overexpression was able to transform NIH3T3 cells, generating greater than or equal to 0.5 cm subcutaneous tumors in 12/12 nude mice within 3 weeks, while none of the negative controls grew. USP2a mRNA was overexpressed in 39% of human prostate cancers, showing 1.6–104 (median 5.48) fold induction relative to normal tissues by qRT-PCR. Gene expression profiling of the same tumors revealed specific signatures in USP2a-overexpressing tumors. Conclusions: Our results demonstrate that USP2a behaves as an oncogene in vitro and in vivo and is overexpressed in organ-confined prostate cancer. These data strongly suggest that this isopeptidase is a potential drug target in prostate cancer. [Table: see text]
The Anatomical Primer. An Embryological Explanation of Human Gross Morphology.
Authors: David A. Langebartel
Journal: Annals of Internal Medicine (1977)

The anatomical primer : an embryological explanation of human gross morphology , The anatomical primer : an embryological explanation of human gross morphology , کتابخانه مرکزی دانشگاه علوم پزشکی ایران
Drug-Test Interactions Handbook
Authors: J. G. Salway
Journal: Annals of Internal Medicine (1991)

Part 1 Bone disease: calcium ionised calcium parathyroid hormone inorganic phosphate. Part 2 Cardiac disease: creating kinase lactate dehydrogenase hydroxbutyrate dehydrogenase cholesterol triglycerides HDL-cholesterol low density lipoproteins. Part 3 Glucose and diabetic tests: insulin glucose glucose tolerance test ketones. Part 4 Hormones: catecholamines adrenaline noradrenaline metadrenaline 5-hydroxyindale acetic acid HMMA cortisol prolactin FSH LH LHRH test testosterone free testosterone oestradiol oestriol progesterone oestrogens 17-ketogenic-steroids sex hormone binding globulin. Part 5 Liver function tests: albumin alanine aminotransferase aspartate aminotransferase alkaline phosphatase ammonia bilirubin bile acids bromosulphthalein retention time gamma glutamyltransferase protein prothrombin time 5-nucleotidase. Part 6 Renal function tests: creatinine creatinine clearance aldosterone osmolality sodium potassium urea. Part 7 Therapeutic drug monitoring: phenytoin paracetamol theoplythine digoxin phenobarbitone lithium primidone valproate carbamazepine. Part 8 Thyroid function tests: thyroxine (T4) free thyroxine triiodothyromine (T3) free T3 reverse T3 TRH test (thyrotrophin releasing hormone) TSH (thyroid stimulating hormone) free T4 index free T3 index thyroxine binding globulin thyroid hormone binding capacity thyroxine binding prealbumin. Part 9 Various other tests: uric acid uric acid clearance pregnancy tests iron colour - green, red, blue, yellow, brown.
Abstract 19185: An Employer-Initiated Challenge to Improve Cardiovascular Health in the Workplace
Authors: Christina M Shay, Diane Brown, Hazel Lonewolf, Debbie Hite, Robyn Sunday-Allen
Journal: Circulation (2012)

Introduction: Concerted attention is focused on achievement of the AHA’s 2020 Strategic Impact Goal which is aimed at a 20% reduction in deaths due to heart disease and stroke. Innovative strategies for promoting awareness of cardiovascular (CV) risk and maintaining and improving CV health are needed for a variety of community-based settings. Objective: To describe an ongoing employer-initiated program aimed at evaluating the effectiveness and efficacy of a CV health intervention focused on maintaining and improving cardiovascular health in an occupational setting. Methods: Administrators from the Oklahoma City Indian Clinic (OKCIC) implemented a voluntary 9-month “Cardiovascular Health Challenge” based on Life’s Simple 7. The OKCIC is an urban healthcare facility for members enrolled in federally-recognized American Indian tribes. Participants were asked to complete My Life Check assessments of Life’s Simple 7 at the beginning, midpoint, and end of the challenge period and to donate a small financial contribution that will be pooled and awarded to the employee with the greatest changes in CV health at the completion of the program. Several program-based workplace resources have been provided to promote healthy behavior change, including an AHA-sponsored walking path at the clinic facility, encouraged daily walking breaks, Life’s Simple 7 materials posted throughout the workplace, pedometers, cooking classes and smoking cessation workshops. Participant feedback regarding program experiences will be solicited and adherence, efficacy and effectiveness will be evaluated. Results: Approximately one-third (n=44) of OKCIC clinic employees are currently enrolled in the CV health challenge. Initial assessments indicate that baseline My Life Check assessments prompted screening of CV health components for a large proportion of participants who were previously unaware of their CVD risk. Conclusions: Incentive-based workplace programs focused on improving CV health represent a unique opportunity to achieve progress towards achievement of the 2020 goals. Maximization of employer encouragement and co-worker camaraderie may be key factors for improved awareness of CVD risk and promotion of healthy behavior change in the workplace.
Hepatitis C virus infection among pregnant women in Slovenia: study on 31,849 samples obtained in four screening rounds during 1999, 2003, 2009 and 2013
Authors: B Kopilović, M Poljak, K Seme, I Klavs
Journal: Eurosurveillance (2015)

The majority of people infected with hepatitis C virus (HCV) are unaware of their infection. Assessment of the prevalence of HCV infection in the general population and in key populations at increased risk is needed for evidence-based testing policies. Our objectives were to estimate the prevalence of antibodies to HCV (anti-HCV), the prevalence of HCV viraemia (HCV RNA), and to describe HCV genotype distribution among pregnant women in Slovenia. Unlinked anonymous testing was performed on residual sera obtained from 31,849 pregnant women for routine syphilis screening during 1999, 2003, 2009, and 2013. Anti-HCV reactive specimens were tested for HCV RNA and HCV genotypes were determined. Annual prevalence of anti-HCV ranged between 0.09% (95% confidence interval (CI): 0.03–0.18) in 2009 and 0.21% (95% CI: 0.12–0.34) in 2003 and HCV RNA positivity between 0.06% (95% CI: 0.02–0.14) in 2009 and 0.14% (95% CI: 0.07–0.25) in 2003. We observed no statistically significant differences in anti-HCV or HCV RNA prevalence between age groups (<20, 20–29 and ≥30 years) in any year and no trend in time. Of 29 HCV active infections, 19 were with genotype 1 and 10 with genotype 3. HCV infection among pregnant women was rare suggesting a low burden in the Slovenian general population. Antenatal screening for HCV in Slovenia could not be recommended.
Single budgets for health and social care are vital for integration, says think tank
Authors: G. Iacobucci
Journal: BMJ (2015)

Health and social care services across England should be commissioned locally from single organisations holding single budgets by 2020, the King’s Fund has urged.

In a new report, Options for Integrated Commissioning: Beyond Barker ,1 the healthcare think tank said that single, ringfenced budgets were an essential step towards ending the historical divide between health and social care, which was a key recommendation of the independent Commission on the Future of Health and Social Care in England (the “Barker Commission”), chaired by the economist Kate Barker.2

The new report argued that …
Abstract 15652: Insulin-Like Growth Factor-1 Induces Vascular Smooth Muscle Cell Contractile Phenotype via a PI3K-Mediated Post-Transcriptional Mechanism Dependent on the α5β1 Integrin
Authors: Chris Blackstock, Yusuke Higashi, Sergiy Sukhanov, Shaw-Yung Shai, Patrice Delafontaine
Journal: Circulation (2014)

In the progression of atherosclerosis, remodeling of the vessel wall occurs in which the extracellular matrix environment is altered and smooth muscle cells (SMCs) undergo a loss of contractile phenotype leading to increased plaque vulnerability and propensity for aneurysm formation. Our earlier studies have shown that insulin-like growth factor-1 (IGF-1)-infusion or SMC-specific IGF-1 overexpression increases contractile SMCs in atherosclerotic plaques of ApoE-/- mice. To investigate signal transduction mechanisms whereby IGF-1 induces contractile protein expression, human aortic SMCs were cultured and treated with 0-100 ng/mL IGF-1 for 0-24 hours in the presence of various inhibitors. IGF-1 induced a dose-dependent increase in expression of SMC contractile proteins, alpha-actin (αSMA) and smooth muscle 22-alpha (SM22α) (~2-fold-increase each with 100 ng/mL, p<0.01, n=10), without affecting mRNA levels. Additionally, IGF-1-upregulation of αSMA and SM22α protein expression was not blocked by actinomycin D...