AB0159 CROSS-CULTURAL ADAPTATION AND VALIDATION OF THE NOCIPLASTIC-BASED FIBROMYALGIA FEATURES (Nff) DIAGNOSTIC TOOL IN MEXICAN FIBROMYALGIA PATIENTS
Authors: E. M. Saldaña-Campos, M. Novoa-Islas, B. Ceniceros-Ruiz, A. P. Santiago-Garcia, P. L. Ibarra-De La Torre, A. Landeros-Sáenz, G. Calderón-Delapeña, C. G. Avalos Fernánder, I. Viruete-Lerma, V. González-Díaz, G. Martínez-Bonilla, J. Uribe-Martínez, S. Cerpa-Cruz
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Fibromyalgia (FM) is a generalized painful chronic disorder in which "nociplastic pain" has been recognized as a pathogenic mechanism. The diagnostic tool "Nociplastic-based Fibromyalgia Features (NFF)" was validated in patients with FM, however, it hasn't been adapted transcultural or validated for it's application in Mexican patients. <h3>Objectives:</h3> This study aimed to perform transcultural adaptation and validate a preliminary diagnostic tool in Mexican FM patients. <h3>Methods:</h3> This cross-sectional study included female FM patients, 18-65 years, and as a control group: primary generalized osteoarthritis (OA) patients, recruited by random sampling, the enrollment took place in the Hospital Civil de Guadalajara "Fray Antonio Alcalde". A sample size of 42 patients (21 in each group) with a power of 80% was calculated; cross-cultural adaptation of NFF was performed with receiver operating characteristic curve analysis combined with likelihood ratios. A two-tailed alpha value &lt;0.05 was set as significant. <h3>Results:</h3> A total of 63 patients were recruited: 33 patients with fibromyalgia and 30 patients with primary generalized osteoarthritis. The demographic and clinical characteristics are shown in Table 1. We proved the prediction capacity according to the scores obtained using the ROC curve, AUC was 0.980, 95% IC 0.953 – 1.0; p &lt; 0.001 (Figure 1). The cut off value ≥ 4 points, with a sensitivity of 86.49% (95% IC 71.23- 95.46), and specificity of 96.15% (95% IC 80.36 – 99.90), positive predictive value 96.97% (95% IC 82.34 -99.55), negative predictive value 83.33% (95% IC 68.80-91.90). <h3>Conclusion:</h3> This cross-culturally adapted version of the Nociplastic-based Fibromyalgia Features tool has adequate validity and diagnostic performance with a good sensitivity and specificity of Nociplastic pain in patients with chronic pain, for discriminating fibromyalgia with a cut-off score like its original version (≥4 pts.), allowing the early diagnosis of fibromyalgia Mexican patients. <h3>REFERENCES:</h3> [1] Pérez-Neri I, Sandoval H, Estêvão MD, Vasanthan LT, Alarcon-Ruiz CA, Ruszkowski J, et al. Central and peripheral mechanisms of pain in fibromyalgia: scoping review protocol. Rheumatol Int [Internet]. 2023 Apr 1 [cited 2023 May 25];43(4):757–62. Available from: https://doi.org/10.1007/s00296-023-05275-9. [2] Ghavidel-Parsa B, Bidari A, Atrkarroushan Z, Khosousi MJ. Implication of the Nociplastic Features for Clinical Diagnosis of Fibromyalgia: Development of the Preliminary Nociplastic-Based Fibromyalgia Features (NFF) Tool. ACR Open Rheumatology [Internet]. 2022 [cited 2023 Jul 17];4(3):260–8. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/acr2.11390. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>