tbuckley/cabot-search huggingface dataset:
Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initiated trial
Authors: Yandong He, Xuhong Huang, Xiaoxia Li, Hongwei Liu, Min Liu, Junjia Tao, Yuanzhou Shan, Hafiz Khuram Raza, Yanqiu Liu, Wenting Zhong, Xue-ping Cao, Yuan-yuan Yang, Ruimei Li, Xian-long Fang, Kang-jian Zhang, Rong Zhang, Feng Liu
Journal: Journal for ImmunoTherapy of Cancer (2024)

To evaluate the safety and preliminary efficacy of YSCH-01 (Recombinant L-IFN adenovirus) in subjects with advanced solid tumors.
Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Authors: Hao Lin, Chaxian Liu, Ankang Hu, Duanwu Zhang, Hui Yang, Ying Mao
Journal: Journal of Hematology & Oncology (2024)

Abstract Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a formidable challenge due to its immunosuppressive microenvironment, thereby confounding conventional therapeutic interventions. Despite the established treatment regimen comprising surgical intervention, radiotherapy, temozolomide administration, and the exploration of emerging modalities such as immunotherapy and integration of medicine and engineering technology therapy, the efficacy of these approaches remains constrained, resulting in suboptimal prognostic outcomes. In recent years, intensive scrutiny of the inhibitory and immunosuppressive milieu within GBM has underscored the significance of cellular constituents of the GBM microenvironment and their interactions with malignant cells and neurons. Novel immune and targeted therapy strategies have emerged, offering promising avenues for advancing GBM treatment. One pivotal mechanism orchestrating immunosuppression in GBM involves the aggregation of myeloid-derived suppressor cells (MDSCs), glioma-associated macrophage/microglia (GAM), and regulatory T cells (Tregs). Among these, MDSCs, though constituting a minority (4–8%) of CD45 + cells in GBM, play a central component in fostering immune evasion and propelling tumor progression, angiogenesis, invasion, and metastasis. MDSCs deploy intricate immunosuppressive mechanisms that adapt to the dynamic tumor microenvironment (TME). Understanding the interplay between GBM and MDSCs provides a compelling basis for therapeutic interventions. This review seeks to elucidate the immune regulatory mechanisms inherent in the GBM microenvironment, explore existing therapeutic targets, and consolidate recent insights into MDSC induction and their contribution to GBM immunosuppression. Additionally, the review comprehensively surveys ongoing clinical trials and potential treatment strategies, envisioning a future where targeting MDSCs could reshape the immune landscape of GBM. Through the synergistic integration of immunotherapy with other therapeutic modalities, this approach can establish a multidisciplinary, multi-target paradigm, ultimately improving the prognosis and quality of life in patients with GBM.
A commentary on “surgical modifications to the conventional kidney transplant technique - the miami transplant institute approach: a retrospective cohort study”
Authors: Zeng Wang, Junjian Wang, Hongyu Chen
Journal: International Journal of Surgery (2024)

aHangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China bDepartment of Nephrology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang,People's Republic of China Zeng Wang and Junjian Wang contributed equally to this work and share first authorship. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, 453 Stadium Road, West Lake District, Hangzhou, Zhejiang 310007, People's Republic of China. E-mail address: [email protected] (H. Chen). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
A commentary on “a new designed full process coverage robot-assisted total hip arthroplasty: a multicentre randomized clinical trial”
Authors: Shu Li, Yong-Gang Bao, Bin Wu
Journal: International Journal of Surgery (2024)

aDepartment of Clinical Medicine, Jining Medical University, No. 133, Hehua Road, Taibai Lake New District, Jining City, 272067, Shandong Province, China bDepartment of Orthopedics, Affiliated Hospital of Jining Medical University, Jining City, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Orthopedic, Affiliated Hospital of Jining Medical University, No. 89, Guhuai Road, Jining City 272029, Shandong Province, China. E-mail address: [email protected] (B. Wu). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Totally laparoscopic versus laparoscopy-assisted distal gastrectomy: the KLASS-07, a randomized controlled trial
Authors: Shin-Hoo Park, Chang-Min Lee, Hoon Hur, Jae-Seok Min, Seung Wan Ryu, Young-Gil Son, Hyun Dong Chae, Oh Jeong, Mi Ran Jung, Chang In Choi, Kyo Young Song, Han Hong Lee, Ho Goon Kim, Ye Seob Jee, Sun-Hwi Hwang, Moon-Soo Lee, Kwang Hee Kim, Sang Hyuk Seo, In Ho Jeong, Myoung Won Son, Chang Hyun Kim, Moon-Won Yoo, Sung Jin Oh, Jeong Goo Kim, Seong Ho Hwang, Sung IL Choi, Kyung Sook Yang, Hua Huang, Sungsoo Park
Journal: International Journal of Surgery (2024)

Strong evidence is lacking as no confirmatory randomized controlled trials (RCTs) have compared the efficacy of totally laparoscopic distal gastrectomy (TLDG) with laparoscopy-assisted distal gastrectomy (LADG). The authors performed an RCT to confirm if TLDG is different from LADG.
Anesthesia risks should not be ignored beyond complications from pulmonary surgery: A commentary on ‘how long can pulmonary resection surgery be performed after SARS-CoV-2 infection? A multicenter retrospective study’
Authors: Kai Kang, Ailin Zhao, Yijun Wu
Journal: International Journal of Surgery (2024)

aDivision of Thoracic Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China bDepartment of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China cLaboratory of Clinical Cell Therapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China Kai Kang, Ailin Zhao These authors contributed equally to the work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding Author. Address: Division of Thoracic Tumor Multimodality Treatment and Laboratory of Clinical Cell Therapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. E-mail address: [email protected] (Y. Wu). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A commentary on “Metabolic tumor burden as a prognostic indicator after neoadjuvant chemotherapy in pancreatic cancer”
Authors: Changyuan Wang, Yi Li, Bole Tian
Journal: International Journal of Surgery (2024)

aDepartment of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, China, 610044 bDepartment of Hepatobiliary Surgery (II), Guizhou Provincial People's Hospital, Guiyang, China, 510002 cDepartment of Breast Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, 610072 Changyuan Wang and Yi Li equally contributed to the study. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: E-mail address: [email protected] (B. Tian). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Advances in AI-based prosthetics development-editorial
Authors: Shivani Chopra, Talha B. Emran
Journal: International Journal of Surgery (2024)

aDepartment of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai - 602105, Tamil Nadu, India bDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Faculty of Allied Health Sciences Daffodil International University Dhaka, Bangladesh. E-mail address: [email protected] (T. B. Emran). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Breast cancer in the era of generative artificial intelligence: Assistant tools for clinical doctors based on ChatGPT
Authors: Yue Zheng, Xu Sun, Kai Kang, Ailin Zhao, Yijun Wu
Journal: International Journal of Surgery (2024)

Zheng, Yue MD; Sun, Xu MD; Kang, Kai MD; Zhao, Ailin MD; Wu, Yijun MD Author Information
Distinct palmitoylation of Foxp3 regulates the function of regulatory T cells via palmitoyltransferases
Authors: Binhui Zhou, Mengjie Zhang, Haoyuan Ma, Ying Wang, Juanjuan Qiu, Yang Liu, Liaoxun Lu, Tianhan Li, Lichen Zhang, Rong Huang, Yanrong Gu, Eryan Kong, Yinming Liang
Journal: Cellular and Molecular Immunology (2024)
A commentary on ‘Could nerve transplantation be the future of this field: a bibliometric analysis about lumbosacral plexus injury’ (Int J Surg 2024 Mar)
Authors: Yiyan Han, Qu Zheng, Tao Zuo
Journal: International Journal of Surgery (2024)

aLiaoning University of Traditional Chinese Medicine bAcupuncture Biology Key Laboratory of the Education Department of Liaoning Province, Liaoning, People's Republic of China Yiyan Han and Qu Zheng contributed equally to this study. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Liaoning University of Traditional Chinese Medicine, Liaoning, People's Republic of China. Tel.: +130 667 567 82. E-mail: [email protected] (T. Zuo). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Endovascular treatment versus standard medical treatment in patients with established large infarct: a cohort study
Authors: Changwei Guo, Linyu Li, Jiandi Huang, Jie Yang, Jiaxing Song, Jiacheng Huang, Zhouzhou Peng, Nizhen Yu, Chang Liu, Weilin Kong, Jinrong Hu, Li Chen, Meng Guo, Chengsong Yue, Dahong Yang, Xiang Liu, Jian Miao, Mengmeng Wang, Xiangyun Luo, Zhaoyin Tang, Xiubing Bai, Duolao Wang, Fengli Li, Qingwu Yang, Wenjie Zi
Journal: International Journal of Surgery (2024)

Previous trials confirmed the benefit of endovascular treatment (EVT) in acute large core stroke, but the effect of EVT on outcomes in these patients based on noncontrast computed tomography (NCCT) in real-world clinical practice was unclear. The aim of this study was to explore the effect of EVT versus standard medical treatment (SMT) in patients with large ischemic core stroke defined as Alberta Stroke Program Early CT Score (ASPECTS) ≤5 based on NCCT alone.
Letter to the editor “Inflammatory biomarkers and nanotechnology: new insights in pancreatic cancer early detection”
Authors: Qihang Yuan, Dong Shang
Journal: International Journal of Surgery (2024)

aPancreas & Biliary Center, Department of General Surgery, Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China bInstitute (College) of Integrative Medicine, Dalian Medical University, Dalian, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: (E-mail: [email protected]). (D. Shang). *Corresponding author. Address: (E-mail: [email protected]) (Q. Yuan). This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0/
Novel Functional Dressing Materials for Intraoral Wound Care
Authors: Yutang Ding, Zhou Zhu, Xin Zhang, Jian Wang
Journal: Advanced Healthcare Materials (2024)

Intraoral wounds represent a particularly challenging category of mucosal and hard tissue injuries, characterized by the unique structures, complex environment, and distinctive healing processes within the oral cavity. They have a common occurrence yet frequently inflict significant inconvenience and pain on patients, causing a serious decline in the quality of life. A variety of novel functional dressings specifically designed for the moist and dynamic oral environment have been developed and realized accelerated and improved wound healing. Thoroughly analyzing and summarizing these materials is of paramount importance in enhancing the understanding and proficiently managing intraoral wounds. In this review, the particular processes and unique characteristics of intraoral wound healing are firstly described. Up-to-date knowledge of various forms, properties, and applications of existing products are then intensively discussed, which are categorized into animal products, plant extracts, natural polymers, and synthetic products. To conclude, this review presents a comprehensive framework of currently available functional intraoral wound dressings, with an aim to provoke inspiration of future studies to design more convenient and versatile materials.
Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease
Authors: Shuling Wang, Yihang Song, Zhijie Wang, Xin Chang, Haicong Wu, Ziwei Yan, Jiayi Wu, Zixuan He, Le Kang, Wenjun Hu, Tian Xia, Zhaoshen Li, Xingxing Ren, Yu Bai
Journal: Cellular and Molecular Immunology (2024)
Generation of Comprehensive GPCR-Transducer-Deficient Cell Lines to Dissect the Complexity of GPCR Signaling
Authors: Ayaki Saito, Ryoji Kise, Asuka Inoue
Journal: Pharmacological Reviews (2024)

G-protein-coupled receptors (GPCRs) compose the largest family of transmembrane receptors and are targets of approximately one-third of FDA approved drugs owing to their involvement in almost all physiological processes. GPCR signaling occurs through the activation of heterotrimeric G-protein complexes and β-arrestins, both of which serve as transducers resulting in distinct cellular responses. Despite seeming simple at first glance, accumulating evidence indicates that activation of either transducer is not a straightforward process, as a stimulation of a single molecule has the potential to activate multiple signaling branches. The complexity of GPCR signaling arises from the aspects of G-protein-coupling selectivity, biased signaling, interpathway crosstalk, and variable molecular modifications generating these diverse signaling patterns. Numerous questions relative to these aspects of signaling remained unanswered until the recent development of CRISPR-Cas9 genome editing. Such genome editing technology presents opportunities to chronically eliminate the expression of G-protein subunits, β-arrestins, GRKs, and many other signaling nodes in the GPCR pathways at one9s convenience. Here, we review the practicality of using CRISPR-Cas9-derived knockout (KO) cells in the experimental contexts of unravelling the molecular details of GPCR signaling mechanisms. To mention a few, KO cells have revealed the contribution of β-arrestins in ERK activation, Gα protein selectivity, GRK-based regulation of GPCRs, and many more, hence validating its broad applicability in GPCR studies. <b>Significance Statement</b> This review emphasizes the practical application of GPCR-effector KO cells in dissecting the intricate regulatory mechanisms of the GPCR signaling network. Currently available cell lines, along with accumulating KO cell lines in diverse cell types, offer valuable resources for systematically elucidating GPCR signaling regulation. Given the association of GPCR signaling with numerous diseases, uncovering the system-based signaling map is crucial for advancing the development of novel drugs targeting specific diseases.
Advancements in precision nanomedicine design targeting the anoikis-platelet interface of circulating tumor cells
Authors: Manqing Tang, Zhijie Zhang, Ping Wang, Feng Zhao, Lin Miao, Yuming Wang, Yingpeng Li, Yunfei Li, Zhonggao Gao
Journal: Acta Pharmaceutica Sinica B (2024)

Tumor metastasis, the apex of cancer progression, poses a formidable challenge in therapeutic endeavors. Circulating tumor cells (CTCs), resilient entities originating from primary tumors or their metastases, significantly contribute to this process by demonstrating remarkable adaptability. They survive shear stress, resist anoikis, evade immune surveillance, and thwart chemotherapy. This comprehensive review aims to elucidate the intricate landscape of CTC formation, metastatic mechanisms, and the myriad factors influencing their behavior. Integral signaling pathways, such as integrin-related signaling, cellular autophagy, epithelial-mesenchymal transition, and interactions with platelets, are examined in detail. Furthermore, we explore the realm of precision nanomedicine design, with a specific emphasis on the anoikis‒platelet interface. This innovative approach strategically targets CTC survival mechanisms, offering promising avenues for combatting metastatic cancer with unprecedented precision and efficacy. The review underscores the indispensable role of the rational design of platelet-based nanomedicine in the pursuit of restraining CTC-driven metastasis.
Publisher Correction: Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency
Authors: Cihan Atila, Julie Refardt, Mirjam Christ-Crain
Journal: Nature Reviews Endocrinology (2024)

In the version of the article initially published, the Fig. 3b n numbers and percentages were duplicates of those in Fig. 3a.This has been corrected, and the Fig. 3b
Distinct eLPB<sup>ChAT</sup> projections for methamphetamine withdrawal anxiety and primed reinstatement of conditioned place preference
Authors: Wenwen Chen, Hao Guo, Ning Zhou, Yuning Mai, Tao Hu, Xing Xu, Teng He, Jun Wen, Shan Qin, Chengyong Liu, Wenzhong Wu, Hee Young Kim, Yu Fan, Feifei Ge, Xiaowei Guan
Journal: Theranostics (2024)

Methamphetamine (METH) withdrawal anxiety symptom and relapse have been significant challenges for clinical practice, however, the underlying neuronal basis remains unclear.Our recent research has identified a specific subpopulation of choline acetyltransferase (ChAT + ) neurons localized in the external lateral portion of parabrachial nucleus (eLPB ChAT ), which modulates METH primed-reinstatement of conditioned place preference (CPP).Here, the anatomical structures and functional roles of eLPB ChAT projections in METH withdrawal anxiety and primed reinstatement were further explored.Methods: In the present study, a multifaceted approach was employed to dissect the LPB ChAT+ projections in male mice, including anterograde and retrograde tracing, acetylcholine (Ach) indicator combined with fiber photometry recording, photogenetic and chemogenetic regulation, as well as electrophysiological recording.METH withdrawal anxiety-like behaviors and METH-primed reinstatement of conditioned place preference (CPP) were assessed in male mice. Results:We identified that eLPB ChAT send projections to PKCδ-positive (PKCδ + ) neurons in lateral portion of central nucleus of amygdala (lCeA PKC δ ) and oval portion of bed nucleus of the stria terminalis (ovBNST PKC δ ), forming eLPB ChAT -lCeA PKC δ and eLPB ChAT -ovBNST PKC δ pathways.At least in part, the eLPB ChAT neurons positively innervate lCeA PKC δ neurons and ovBNST PKC δ neurons through regulating synaptic elements of presynaptic Ach release and postsynaptic nicotinic acetylcholine receptors (nAChRs).METH withdrawal anxiety and METH-primed reinstatement of CPP respectively recruit eLPB ChAT -lCeA PKC δ pathway and eLPB ChAT -ovBNST PKC δ pathway in male mice. Conclusion:Our findings put new insights into the complex neural networks, especially focusing on the eLPB ChAT projections.The eLPB ChAT is a critical node in the neural networks governing METH withdrawal anxiety and primed-reinstatement of CPP through its projections to the lCeA PKC δ and ovBNST PKC δ , respectively.