tbuckley/cabot-search huggingface dataset:
Real-Time Electronic Patient Portal Use Among Emergency Department Patients
Authors: Robert W. Turer, Samuel A. McDonald, Christoph U. Lehmann, Bhaskar Thakur, Sayon Dutta, Richard A. Taylor, Christian C. Rose, Adam Frisch, Kristian Feterik, Craig Norquist, Carrie K. Baker, Jeffrey A. Nielson, David Cha, Brian Kwan, Christian Dameff, James P. Killeen, Michael K. Hall, Robert C. Doerning, S. Trent Rosenbloom, Casey Distaso, Bryan D. Steitz
Journal: JAMA Network Open (2024)

Importance Patients with inequitable access to patient portals frequently present to emergency departments (EDs) for care. Little is known about portal use patterns among ED patients. Objectives To describe real-time patient portal usage trends among ED patients and compare demographic and clinical characteristics between portal users and nonusers. Design, Setting, and Participants In this cross-sectional study of 12 teaching and 24 academic-affiliated EDs from 8 health systems in California, Connecticut, Massachusetts, Ohio, Tennessee, Texas, and Washington, patient portal access and usage data were evaluated for all ED patients 18 years or older between April 5, 2021, and April 4, 2022. Exposure Use of the patient portal during ED visit. Main Outcomes and Measures The primary outcomes were the weekly proportions of ED patients who logged into the portal, viewed test results, and viewed clinical notes in real time. Pooled random-effects models were used to evaluate temporal trends and demographic and clinical characteristics associated with real-time portal use. Results The study included 1 280 924 unique patient encounters (53.5% female; 0.6% American Indian or Alaska Native, 3.7% Asian, 18.0% Black, 10.7% Hispanic, 0.4% Native Hawaiian or Pacific Islander, 66.5% White, 10.0% other race, and 4.0% with missing race or ethnicity; 91.2% English-speaking patients; mean [SD] age, 51.9 [19.2] years). During the study, 17.4% of patients logged into the portal while in the ED, whereas 14.1% viewed test results and 2.5% viewed clinical notes. The odds of accessing the portal (odds ratio [OR], 1.36; 95% CI, 1.19-1.56), viewing test results (OR, 1.63; 95% CI, 1.30-2.04), and viewing clinical notes (OR, 1.60; 95% CI, 1.19-2.15) were higher at the end of the study vs the beginning. Patients with active portal accounts at ED arrival had a higher odds of logging into the portal (OR, 17.73; 95% CI, 9.37-33.56), viewing test results (OR, 18.50; 95% CI, 9.62-35.57), and viewing clinical notes (OR, 18.40; 95% CI, 10.31-32.86). Patients who were male, Black, or without commercial insurance had lower odds of logging into the portal, viewing results, and viewing clinical notes. Conclusions and Relevance These findings suggest that real-time patient portal use during ED encounters has increased over time, but disparities exist in portal access that mirror trends in portal usage more generally. Given emergency medicine’s role in caring for medically underserved patients, there are opportunities for EDs to enroll and train patients in using patient portals to promote engagement during and after their visits.
Inflammatory tissue priming: novel insights and therapeutic opportunities for inflammatory rheumatic diseases
Authors: Markus H Hoffmann, Henriette Kirchner, Gerhard Krönke, Gabriela Riemekasten, Michael Bonelli
Journal: Annals of the Rheumatic Diseases (2024)

Due to optimised treatment strategies and the availability of new therapies during the last decades, formerly devastating chronic inflammatory diseases such as rheumatoid arthritis or systemic sclerosis (SSc) have become less menacing. However, in many patients, even state-of-the-art treatment cannot induce remission. Moreover, the risk for flares strongly increases once anti-inflammatory therapy is tapered or withdrawn, suggesting that underlying pathological processes remain active even in the absence of overt inflammation. It has become evident that tissues have the ability to remember past encounters with pathogens, wounds and other irritants, and to react more strongly and/or persistently to the next occurrence. This priming of the tissue bears a paramount role in defence from microbes, but on the other hand drives inflammatory pathologies (the Dr Jekyll and Mr Hyde aspect of tissue adaptation). Emerging evidence suggests that long-lived tissue-resident cells, such as fibroblasts, macrophages, long-lived plasma cells and tissue-resident memory T cells, determine inflammatory tissue priming in an interplay with infiltrating immune cells of lymphoid and myeloid origin, and with systemically acting factors such as cytokines, extracellular vesicles and antibodies. Here, we review the current state of science on inflammatory tissue priming, focusing on tissue-resident and tissue-occupying cells in arthritis and SSc, and reflect on the most promising treatment options targeting the maladapted tissue response during these diseases.
Cumulative Systolic Blood Pressure and Incident Stroke Type Variation by Race and Ethnicity
Authors: Kimson E. Johnson, Hanyu Li, Min Zhang, Mellanie V. Springer, Andrzej T. Galecki, Rachael T. Whitney, Rebecca F. Gottesman, Rodney A. Hayward, Stephen Sidney, Mitchell S. V. Elkind, W. T. Longstreth, Susan R. Heckbert, Yariv Gerber, Kevin J. Sullivan, Deborah A. Levine
Journal: JAMA Network Open (2024)

Importance Stroke risk varies by systolic blood pressure (SBP), race, and ethnicity. The association between cumulative mean SBP and incident stroke type is unclear, and whether this association differs by race and ethnicity remains unknown. Objective To examine the association between cumulative mean SBP and first incident stroke among 3 major stroke types—ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH)—and explore how these associations vary by race and ethnicity. Design, Setting, and Participants Individual participant data from 6 US longitudinal cohorts (January 1, 1971, to December 31, 2019) were pooled. The analysis was performed from January 1, 2022, to January 2, 2024. The median follow-up was 21.6 (IQR, 13.6-31.8) years. Exposure Time-dependent cumulative mean SBP. Main Outcomes and Measures The primary outcome was time from baseline visit to first incident stroke. Secondary outcomes consisted of time to first incident IS, ICH, and SAH. Results Among 40 016 participants, 38 167 who were 18 years or older at baseline with no history of stroke and at least 1 SBP measurement before the first incident stroke were included in the analysis. Of these, 54.0% were women; 25.0% were Black, 8.9% were Hispanic of any race, and 66.2% were White. The mean (SD) age at baseline was 53.4 (17.0) years and the mean (SD) SBP at baseline was 136.9 (20.4) mm Hg. A 10–mm Hg higher cumulative mean SBP was associated with a higher risk of overall stroke (hazard ratio [HR], 1.20 [95% CI, 1.18-1.23]), IS (HR, 1.20 [95% CI, 1.17-1.22]), and ICH (HR, 1.31 [95% CI, 1.25-1.38]) but not SAH (HR, 1.13 [95% CI, 0.99-1.29]; P = .06). Compared with White participants, Black participants had a higher risk of IS (HR, 1.20 [95% CI, 1.09-1.33]) and ICH (HR, 1.67 [95% CI, 1.30-2.13]) and Hispanic participants of any race had a higher risk of SAH (HR, 3.81 [95% CI, 1.29-11.22]). There was no consistent evidence that race and ethnicity modified the association of cumulative mean SBP with first incident stroke and stroke type. Conclusions and Relevance The findings of this cohort study suggest that cumulative mean SBP was associated with incident stroke type, but the associations did not differ by race and ethnicity. Culturally informed stroke prevention programs should address modifiable risk factors such as SBP along with social determinants of health and structural inequities in society.
Systematic literature review to inform the EULAR recommendations for the use of imaging in crystal-induced arthropathies in clinical practice
Authors: Irina Gessl, Garifallia Sakellariou, Brigitte Wildner, Georgios Filippou, Peter Mandl, Maria Antonietta D’Agostino, Victoria Navarro-Compán
Journal: Annals of the Rheumatic Diseases (2024)

To summarise current data regarding the use of imaging in crystal-induced arthropathies (CiAs) informing a European Alliance of Associations for Rheumatology task force.
ABBV-319: A CD19-targeting glucocorticoid receptor modulator antibody-drug conjugate therapy for B-cell malignancies
Authors: Chewei Anderson Chang, Ethan Emberley, Aloma L. D'Souza, Weilong Zhao, Cormac Cosgrove, Karen Parrish, Diya Mitra, Elmer Payson, Anatol Oleksijew, Paul Ellis, Luis Rodriguez, Ryan Duggan, Cara Hrusch, Loren Lasko, Wissam Assaily, Pingping Zheng, Wei Liu, Axel Hernandez, Kimberley McCarthy, Zhaomei Zhang, Geunbae Rha, Zhensheng Cao, Yingchun Li, Olivia Perng, Jos Campbell, Gloria Zhang, Tyler Curran, Milan Bruncko, Christopher C. Marvin, Adrian Hobson, Michael McPherson, Tamar Uziel, Marybeth A. Pysz, Xi Zhao, Alex Bankovich, Joel Hayflick, Michael McDevitt, Kevin J. Freise, Susan Morgan-Lappe, James W. Purcell
Journal: Blood (2024)

Abstract Glucocorticoids are key components of the standard-of-care treatment regimens for B-cell malignancy. However, systemic glucocorticoid treatment is associated with several adverse events. ABBV-319 is a CD19-targeting antibody-drug conjugate engineered to reduce glucocorticoid-associated toxicities while possessing 3 distinct mechanisms of action (MOA) to increase therapeutic efficacy: (1) antibody-mediated delivery of a glucocorticoid receptor modulator (GRM) payload to activate apoptosis, (2) inhibition of CD19 signaling, and (3) enhanced fragment crystallizable (Fc)–mediated effector function via afucosylation of the antibody backbone. ABBV-319 elicited potent GRM-driven antitumor activity against multiple malignant B-cell lines in vitro, as well as in cell line-derived xenografts and patient-derived xenografts (PDXs) in vivo. Remarkably, a single dose of ABBV-319 induced sustained tumor regression and enhanced antitumor activity compared with repeated dosing of systemic prednisolone at the maximum tolerated dose in mice. The unconjugated CD19 monoclonal antibody (mAb) also displayed antiproliferative activity in a subset of B-cell lymphoma cell lines through the inhibition of phosphoinositide 3-kinase signaling. Moreover, afucosylation of CD19 mAb enhanced Fc-mediated antibody-dependent cellular cytotoxicity. Notably, ABBV-319 displayed superior efficacy compared with afucosylated CD19 mAb in human CD34+ peripheral blood mononuclear cell–engrafted NSG-Tg(Hu-IL15) transgenic mice, demonstrating enhanced antitumor activity when multiple MOAs are enabled. ABBV-319 also showed durable antitumor activity across multiple B-cell lymphoma PDX models, including nongerminal center B-cell diffuse large B-cell lymphoma and relapsed lymphoma after R-CHOP treatment. Collectively, these data support the ongoing evaluation of ABBV-319 in a phase 1 clinical trial.
Motive and Opportunity: MYC rearrangements in high-grade B-cell lymphoma with MYC and BCL2 rearrangements-an LLMPP study
Authors: Laura K Hilton, Brett J Collinge, Susana Ben-Neriah, Waleed Alduaij, Haya Shaalan, Andrew Weng, Manuela Cruz, Graham W. Slack, Pedro Farinha, Tomoko Miyata-Takata, Merrill Boyle, Barbara Meissner, James R. Cook, Sarah L. Ondrejka, German Ott, Andreas Rosenwald, Elías Campo, Catalina Amador, Timothy C Greiner, Philipp W Raess, Joo Y. Song, Giorgio GA Inghirami, Elaine S Jaffe, Dennis D Weisenburger, Wing C. Chan, Klaus Beiske, Kai Fu, Jan Delabie, Stafania Pittaluga, Javeed Iqbal, George Wright, Laurie H. Sehn, Kerry J. Savage, Andrew J Mungall, Andrew L Feldman, Louis M Staudt, Christian Steidl, Lisa M. Rimsza, Ryan D Morin, David W. Scott
Journal: Blood (2024)
Plasma Kidney Injury Molecule-1 for Preoperative Prediction of Renal Cell Carcinoma Versus Benign Renal Masses, and Association With Clinical Outcomes
Authors: Wenxin Xu, Valerie Gaborieau, Samuel M. Niman, Anush Mukeria, Xiaowen Liu, Krishna P. Maremanda, Ayumi Takakura, David Zaridze, Matthew L. Freedman, Wanling Xie, David F. McDermott, Toni K. Choueiri, Paul J. Catalano, Venkata Sabbisetti, Joseph V. Bonventre, Phillip M. Pierorazio, Nirmish Singla, Paul Brennan, Rupal S. Bhatt
Journal: Journal of Clinical Oncology (2024)

PURPOSE Both clear cell and papillary renal cell carcinomas (RCCs) overexpress kidney injury molecule-1 (KIM-1). We investigated whether plasma KIM-1 (pKIM-1) may be a useful risk stratification tool among patients with suspicious renal masses. METHODS Prenephrectomy pKIM-1 was measured in two independent cohorts of patients with renal masses. Cohort 1, from the prospective K2 trial, included 162 patients found to have clear cell RCC (cases) and 162 patients with benign renal masses (controls). Cohort 2 included 247 patients with small (cT1a) renal masses from an academic biorepository, of whom 184 had RCC. We assessed the relationship between pKIM-1, surgical pathology, and clinical outcomes. RESULTS In Cohort 1, pKIM-1 distinguished RCC versus benign masses with area under the receiver operating curve (AUC-ROC, 0.81 [95% CI, 0.76 to 0.86]). In Cohort 2 (cT1a only), pKIM-1 distinguished RCC versus benign masses (AUC-ROC, 0.74 [95% CI, 0.67 to 0.80]) and the addition of pKIM-1 to an established nomogram for predicting malignancy improved the model AUC-ROC (0.65 [95% CI, 0.57 to 0.74] v 0.78 [95% CI, 0.72 to 0.85]). A pKIM-1 cutpoint identified using Cohort 2 demonstrated sensitivity of 92.5% and specificity of 60% for identifying RCC in Cohort 1. In long-term follow-up of RCC cases (Cohort 1), higher prenephrectomy pKIM-1 was associated with worse metastasis-free survival (multivariable MFS hazard ratio [HR] 1.29 per unit increase in log pKIM-1, 95% CI, 1.10 to 1.53) and overall survival (multivariable OS HR 1.31 per unit increase in log pKIM-1, 95% CI, 1.10 to 1.54). In long-term follow-up of Cohort 2, no metastatic events occurred, consistent with the favorable prognosis of resected cT1a RCC. CONCLUSION Among patients with renal masses, pKIM-1 is associated with malignant pathology, worse MFS, and risk of death. pKIM-1 may be useful for selecting patients with renal masses for intervention versus surveillance.
Continuous Glucose Monitoring Profiles in Pregnancies With and Without Gestational Diabetes Mellitus
Authors: Celeste Durnwald, Roy W. Beck, Zoey Li, Elizabeth Norton, Richard M. Bergenstal, Mary Johnson, Sean Dunnigan, Matthew Banfield, Katie Krumwiede, Judy Sibayan, Peter Calhoun, Anders L. Carlson
Journal: Diabetes Care (2024)

To determine whether continuous glucose monitoring (CGM)-derived glycemic patterns can characterize pregnancies with gestational diabetes mellitus (GDM) as diagnosed by standard oral glucose tolerance test at 24-28 weeks' gestation compared with those without GDM.
Immunogenicity, reactogenicity, and safety of two-dose adjuvanted herpes zoster subunit vaccine in patients with systemic lupus erythematosus in South Korea: a single-centre, randomised, double-blind, placebo-controlled trial
Authors: Jin Kyun Park, Miriam Kim, Ji In Jung, Ju Yeon Kim, Heejin Jeong, Jun Won Park, Kevin L Winthrop, Eun Bong Lee
Journal: The Lancet Rheumatology (2024)
A commentary on ‘Circulating 25-hydroxyvitamin D concentration can predict bowel resection risk among individuals with inflammatory bowel disease in a longitudinal cohort with 13 years of follow-up’
Authors: Haoyu An, Hao Chi, Jie Liu
Journal: International Journal of Surgery (2024)

aSchool of Medicine, The Chinese University of Hong Kong, Shatin, NT, 999077, Hong Kong bClinical Medical College, Southwest Medical University, Luzhou, 646000, China cDepartment of general surgery, Dazhou Central Hospital, Dazhou, 635000, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding Author: Dazhou Central Hospital, Dazhou, China, Email: [email protected] (J. Liu). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Insights into ChatGPT application in renal transplantation – correspondence
Authors: Zeyu Han, Xianyanling Yi, Jin Li, Yaxiong Tang, Dazhou Liao, Tianyi Zhang, Jianzhong Ai
Journal: International Journal of Surgery (2024)

Han, Zeyu; Yi, Xianyanling; Li, Jin; Tang, Yaxiong; Liao, Dazhou; Zhang, Tianyi; Ai, Jianzhong Author Information
Regulating tumor innervation by nanodrugs potentiates cancer immunochemotherapy and relieve chemotherapy-induced neuropathic pain
Authors: Shuting Zuo, Zhenyu Wang, Xiaoman Jiang, Yuewu Zhao, Panyue Wen, Jine Wang, Junjie Li, Masaru Tanaka, Shao Dan, Yan Zhang, Zheng Wang
Journal: Biomaterials (2024)
Small graft size and hepatocellular carcinoma outcomes in living donor liver transplantation: a retrospective multicentric cohort study
Authors: Deok-Gie Kim, Shin Hwang, Kwang-Woong Lee, Jong Man Kim, Young Kyoung You, Donglak Choi, Je Ho Ryu, Bong-Wan Kim, Dong-Sik Kim, Jai Young Cho, Yang Won Nah, Man ki Ju, Tae-Seok Kim, Jae Geun Lee, Myoung Soo Kim, Alessandro Parente, Ki-Hun Kim, Andrea Schlegel, Soo Jin Na Choi, Dong Jin Joo
Journal: International Journal of Surgery (2024)

This study examined associations between the graft-to-recipient weight ratio (GRWR) for adult-to-adult living donor liver transplantation (LDLT) and hepatocellular carcinoma (HCC) outcomes.
The impact of surgical timing on outcome in acute appendicitis in adults – a retrospective observational Population-Based cohort study
Authors: Konstantin Uttinger, Philip Baum, Johannes Diers, Daniel Seehofer, Christoph-Thomas Germer, Armin Wiegering
Journal: International Journal of Surgery (2024)

Acute appendicitis is a global disease with high incidence. The main objective was to assess the association between time from admission to surgery (TAS) and surgery during emergency hours with operative outcome in light of conflicting evidence.
Effect of pretransplant dialysis modalities on pancreas-kidney transplant outcomes: A systematic review and meta-analysis
Authors: Yue Li, Yangming Tang, Yu Fan, Tao Lin, Turun Song
Journal: International Journal of Surgery (2024)

Background: The impact of different pre-transplant dialysis modalities on post-transplant outcomes for pancreas-kidney transplantation is currently unclear. This study aims to assess the association between pretransplant dialysis modalities (hemodialysis and peritoneal dialysis) and outcomes following pancreas-kidney transplantation. Methods: We searched PubMed, EMBASE, and the Cochrane Library for relevant studies published from inception until December 1, 2023. We included studies that examined the relationship between pre-transplant dialysis modalities and clinical outcomes for pancreas-kidney transplantation. The primary outcomes considered were patient, pancreas and kidney graft survival, and intra-abdominal infection. Results: A total of 13 studies involving 1503 pancreas-kidney transplant recipients were included. Pretransplant hemodialysis was associated with improved pancreas graft survival (hazard ratio = 0.71, 95% confidence interval [CI]: 0.51 - 0.99, I² = 12%) and a decreased risk of intra-abdominal infection (odds ratio [OR] = 0.69, 95% CI: 0.51 – 0.93, I² = 5%). However, no significant association was found between the dialysis modalities and patient or kidney graft survival. Furthermore, pre-transplant hemodialysis was linked to a reduced risk of anastomotic leak (OR = 0.32, 95% CI: 0.161 – 0.68, I² = 0%) and graft thrombosis (OR = 0.56, 95% CI: 0.33 – 0.96, I² = 20%). Conclusion: Pre-transplant hemodialysis is the preferred dialysis modality while awaiting pancreas-kidney transplantation, although well-designed prospective studies are needed to confirm these findings.
Optimizing post-transplantation outcomes: the role of multi-omics, artificial intelligence, and animal models in addressing immunosuppression-associated hepatotoxicity
Authors: Yongguang Liu, Runtao Feng, Jianrong Chen, Hongyan Yan, Xiaoyou Liu
Journal: International Journal of Surgery (2024)

Liu, Yongguang; Feng, Runtao; Chen, Jianrong; Yan, Hongyan; Liu, Xiaoyou Author Information
Comment on ‘HER2 overexpression predicts pathological T2 stage and improved survival in de novo muscle-invasive bladder cancer after immediate radical cystectomy: a retrospective cohort study’
Authors: Yingping Liu, Xingxing Zhang, Panfeng Shang
Journal: International Journal of Surgery (2024)

aThe Second Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou, 730000, China bDepartment of Urology, Institute of Urology, Key Laboratory of Urological Diseases in Gansu Province, Gansu Nephro-Urological Clinical Center, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, China Yingping Liu, Xingxing Zhang These authors contribute to this work equally. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Urology, Institute of Urology, Key Laboratory of Urological Diseases in Gansu Province, Gansu Nephro-Urological Clinical Center, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, People's Republic of China. Tel.: +86 13919785295. E-mail address: [email protected] (P. Shang). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Letter to the Editor “A decision tree model to help treatment decision-making for severe spontaneous intracerebral hemorrhage”
Authors: Hang-Tsung Liu, Ching-Hua Hsieh
Journal: International Journal of Surgery (2024)

Department of Trauma Surgery, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University, College of Medicine, Kaohsiung, Taiwan, 83301. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: E-mail address: [email protected] (C.-H.H.) This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
A commentary on “A CT-based deep learning model predicts overall survival in patients with muscle invasive bladder cancer after radical cystectomy: a multicenter retrospective cohort study”
Authors: Yanghuang Zheng, Hongjin Shi, Bing Hai, Jinsong Zhang
Journal: International Journal of Surgery (2024)

aDepartment of Urology, The Second Affiliated Hospital of Kunming Medical University, Yunnan, 650106, China bDepartment of Respiratory Medicine, The Second Affiliated Hospital of Kunming Medical University, Yunnan, 650106, China Co-authors: Yanghuang Zheng and Hongjin Shi equally contributed to the article. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: E-mail address: [email protected] (J-S.Z.). *Corresponding author. Address: E-mail address: [email protected] (B.H). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/