tbuckley/cabot-search huggingface dataset:
Abstract 2552: Hypertrophic Cardiomyopathy in Children: Do Adult Risk Factors for Cardiac Death Apply
Authors: Jamie A Decker, Joseph W Rossano, E. O’Brian Smith, Bryan C Cannon, Sarah K Clunie, John L Jefferies, Jeffrey K Kim, Jack F Price, William J Dreyer, Jeffrey A Towbin, Susan W Denfield
Journal: Circulation (2007)

Introduction : Annual mortality in children with hypertrophic cardiomyopathy (HCM) has been reported to be 1– 6%. Risk factors for death in adult HCM patients have been characterized; their application to pediatric HCM is unknown. The purpose of this study was to correlate adult risk factors with outcomes in our pediatric population using a standard management strategy. Methods : A retrospective cohort study of children with HCM was performed. Death and cardiac transplant were the primary outcomes. Diagnosis was based on asymmetric septal or concentric hypertrophy as determined by echocardiography. Exclusion criteria included: genetic syndrome, mitochondrial or metabolic disorder, infants of diabetic mothers, congenital heart disease, systemic hypertension, diagnosis &gt;18 years of age, or follow-up &lt;1 year. Results : From 1/1/85 to 10/1/06, 96 patients met inclusion criteria. Mean age at diagnosis was 10.6 ± 5.4 years. Mean follow-up was 6.5 ± 5.2 years. 11 patients had an adverse outcome (7 deaths, 4 transplants). Kaplan-Meier analysis predicts an 82% survival over 20 years. Evidence of left ventricular outflow tract obstruction (LVOTO) occurred in =6% of patients, syncope in 23% and a family history for malignant HCM in 17%. Aborted sudden death occurred in 6%. 10% had non-sustained ventricular tachycardia. 58% of patients underwent at least one exercise treadmill test. All patients were restricted from strenuous activity. 95% of patients were on a β-blocker or calcium channel blocker, with 10% on both. Additional intervention depended on symptoms, family history, and degree of LVOTO. 17% had an implantable defibrillator (ICD). 10% were given a pacemaker due to LVOTO, and 5% underwent left ventricular myectomy. Only extreme LVH (&gt;6 z-scores for BSA) and a blunted blood pressure response to exercise were statistically significant for worse outcomes (both p&lt;0.02). Conclusions : A low mortality/transplantation rate occurred in children with isolated HCM whose management consisted of exercise restriction and medication, with or without an ICD. Management that included myectomy was uncommon. Patients with extreme LVH and a blunted blood pressure response to exercise are high-risk individuals.
Abstract P139: A Paradoxical Increase in Brain Temperature Occurs Early During Cardiopulmonary Arrest.
Authors: Manuel C Boller, Joseph M Katz, Lance B Becker
Journal: Circulation (2008)

Introduction : In patients with cardiac arrest, brain cooling is a powerful intervention to improve neurological outcome. However, brain temperature variation during the initial phase of untreated cardiac arrest has not been well characterized. Objective : To describe passive changes in brain temperature in early untreated cardiac arrest. Methods : Eleven domestic swine (35 kg) were anesthetized and routine respiratory and cardiovascular parameters were monitored and recorded. Temperature was recorded from various sites including the forebrain. External heat support was adjusted to maintain rectal temperature at 37±0.5 °C at baseline, but was discontinued thereafter. Ventricular fibrillation was then induced and cardiac arrest remained untreated for 15 minutes. During this phase, forebrain temperature was recorded every 60 seconds. Results : The brain temperature increased in all animals after induction of cardiac arrest and remained above baseline for the duration of the study period. Peak mean (±SEM) increase above baseline was 0.26 (±0.03) °C and was reached after 9 minutes. Brain temperature slowly declined thereafter. The maximum and minimum temperature increase in individual animals was 0.42 °C and 0.13 °C, respectively. Conclusions : Brain temperature consistently and rapidly increases in the early phase of untreated cardiac arrest in anesthetized swine. This may parallel ongoing, yet diminishing, heat production from cerebral metabolic activity in the face of cessation of convective heat removal via cerebral blood flow.
Abstract 358: Beneficial Effects of Cardiac Progenitor Cells on LV Function 1 Year after Treatment in Rats with Myocardial Infarction
Authors: Xian-liang Tang, Gregg Rokosh, Santosh K Sanganalmath, Yong Peng, Fanping Yuan, Shujing Dai, Jingyao Mu, Qiuli Bi, Chengxin Li, Ning Chen, Hiroshi Sato, Buddhadeb Dawn, Piero Anversa, Roberto Bolli
Journal: Circulation (2008)

We have previously shown that administration of cardiac progenitor cells (CPCs) to rats with either acute or chronic myocardial infarction (MI) results in functional and structural LV improvement a...
Effectiveness of restarting lithium treatment after its discontinuation in bipolar I and bipolar II disorders
Authors: L Tondo, R J Baldessarini, G Floris, N Rudas
Journal: American Journal of Psychiatry (1997)

Objective: This study tested the hypothesis that resumption of lithium treatment of bipolar disorders may be less effective after maintenance treatment has been discontinued.Method: Eighty-six patients with type I or II bipolar disorder, not selected according to response to treatment, were followed prospectively during two periods of lithium maintenance treatment averaging 4.6 and 4.4 years.Morbidity (illness episodes per year, hospitalizations per year, percentage of time ill) was assessed, and use of adjunctive medication was rated.Results: Morbidity was similar in the first and second treatment periods (mean number of episodes=0.83 and 0.94 per year, respectively; mean percentage of time ill=18.0%and 24.2%), with no differences in numbers of manic and depressive episodes or differences by gender, diagnostic type, length of first treatment, interval between treatments, or discontinuation rate.There was 12.8% more use of adjunctive medication in the second period.Conclusions: The efficacy of lithium did not differ significantly between the first and second treatment periods.
Dual PI3Kδ/γ Inhibition By RP6530 Induces Apoptosis and Cytotoxicity In B-Lymphoma Cells
Authors: Swaroop Vakkalanka, Srikant Viswanadha, Eugenio Gaudio, Emanuele Zucca, Francesco Bertoni, Elena Bernasconi, Davide Rossi, Anastasios Stathis
Journal: Blood (2013)
Abstract 5133: Lifetime Risk of Stroke in Atomic-bomb Survivors-Adult Health Study in Hiroshima and Nagasaki, Japan
Authors: Ikuno Takahashi, Susan M Geyer, Saeko Fujiwara, Nobuo Nishi, Tomohiko Ohshita, Tetsuya Takahashi, Masayasu Matsumoto
Journal: Circulation (2009)

Background : It is suggested that Atomic-bomb radiation may cause increase in stroke mortality. The objective of this study was to estimate the radiation effect on lifetime risk (LTR) of stroke among Atomic-bomb survivors. Our hypothesis is that even low-dose radiation may cause stroke incidence in different mechanism of high-dose irradiation. Methods : We evaluated radiation effect on stroke incidence by dose and age at time of bombing (ATB) groups: &lt; 0.005 Gy (n=2607), 0.005– 0.5 Gy (n=2051), 0.5–1.0 Gy (n=939), 1.0+Gy (n=824) and &lt; 10 y.o. (younger) vs. ≥ 10 y.o. (older) ATB. Adult Health Study (AHS) subjects were Atomic-bomb survivors and unexposed controls. Participants have been followed biennially by RERF since 1958. Eligible subjects were alive and stroke-free at baseline age (55–56 y.o.) and had corresponding blood pressure data available. Stroke events were all reviewed by WHO MONICA methods using health exam and death certificate information. Cumulative incidence and LTR analyses accounted for the competing risk of non-stroke death with consideration of blood pressure levels. Results : Median follow-up for the 7487 subjects was 16.1 years (range: 1 day to 44.3 years), where 3788 subjects had died, 868 had a documented first-ever stroke event (356 male, 512 female). These stroke events were classified as hemorrhagic (n=231), thromboembolic (n=542), and unspecified (n=95). A minority of subjects (11%) was &lt;10 y.o. ATB, and dose was unknown in 1066 subjects. There was no significant difference among 4 dose-groups in cumulative incidence rates of any stroke as well as hemorrhagic or thromboembolic stroke. However, there was a significant difference when we considered age ATB within dose groups (p=0.0003). Ten-years risk estimates for any stroke were 3.0% in 0 – 0.005 Gy, 2.0% in 0.005– 0.5 Gy, 5.0% in 0.5–1.0 Gy, 11.1% in 1.0+ Gy (p&lt;0.0001), even within subtypes (hemorrhagic stroke; p=0.053, thromboembolic stroke; p=0.0034). Conclusion : Our results suggest that Atomic-bomb radiation in young subjects increases risk of stroke. Continued observation is needed due to the limited follow-up time in AHS subjects &lt;10 y.o. ATB. This is the first report on the LTR of stroke incidence supporting the long-term radiation related increase in stroke mortality.
Induction chemotherapy using carboplatin (C), irinotecan (I), and paclitaxel (P) with pegfilgrastim support followed by concurrent thoracic conformal radiation therapy (TCRT) with weekly CP and daily gefitinib
Authors: D. E. Morris, J. S. Halle, T. Stinchcombe, J. G. Rosenman, A. Mears, M. Tynan, M. A. Socinski
Journal: Journal of Clinical Oncology (2005)

7311 Background: Chemoradiation is a standard of care in stage IIIA/B NSCLC. Locoregional and distant control of micrometastatic disease remain suboptimal. Methods: We designed a trial with intensified induction therapy (consisting of C AUC 5, I 100mg/m2, and P 175mg/m2 on d1 and 22 with pegfilgrastim support) followed by TCRT to 74 Gy in 2 Gy fractions concurrent with weekly CP chemotherapy (AUC 2 and 45 mg/m2, respectively) and daily gefitinib (Iressa) (250 mg) followed by 2 years of daily gefitinib (250 mg). The primary objective is to assess toxicity of this combined modality regimen. Secondary objectives are to estimate efficacy, recurrence patterns, survival, and failure free survival of this treatment regimen. Results: Since March 2004, 11 patients have been enrolled (6M:5F, median age 59 (44–82), 9 IIIA: 2 IIIB, 27% > 5% wt. loss). One pt received one cycle of CIP and was deemed not evaluable due to prior therapy that interfered with delivery of protocol treatment. One gr 4 hematologic toxicity and no gr 3 non-hematologic toxicity was observed in the induction therapy. All pts have had (V20) (lung volume receiving > 20 Gy) of less than 35%. One pt failed to complete the course of induction and combined modality therapy discontinuing at 58 Gy due to pulmonary emboli and pericardial tamponade secondary to anti-coagulation with subsequent decline in performance status. One pt developed unexpected gr 2 esophageal stricture after 58 Gy. One pt developed gr 5 pulmonary toxicity less than 60 days from completion of concurrent therapy from presumed due to treatment. 4 pts have developed acneiform rashes. No pt has experienced ophthalmologic toxicity. Data is not yet sufficient to report the protocol’s secondary objectives, but no pt has progressed. Only 1 pt has died. Treatment and enrollment is continuing. Conclusions: -1- Induction CIP remains active and tolerable for NSCLC pts, -2- Combination therapy of radiation with weekly CP and daily gefitinib has been tolerable but close monitoring for pulmonary toxicity remains necessary, -3- Further follow-up for toxicity, recurrence patterns, and survival will be reported. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Amgen
Phase I/II Study of Combination of Sorafenib, Vorinostat, and Bortezomib in Acute Myeloid Leukemia with FLT3-ITD Mutation or Monosomy 5, 7, or Complex Cytogenetics
Authors: Mohammad Abu Zaid, H. Scott Boswell, Larry D. Cripe, Yan Liu, Jill Weisenbach, Hamid Sayar
Journal: Blood (2014)
Abstract 20574: Is Myocardial Perfusion Imaging Appropriate in All Patients with Excellent Functional Capacity?
Authors: Steven Carr, Prashan Thiagarajah, Diane Vido, Indu G Poornima
Journal: Circulation (2010)

Background:  Functional capacity (FC) determined by the exercise stress test (EST) is an important predictor of all-cause mortality. A recent study suggested a limited role for myocardial perfusion imaging (MPI) in patients with excellent FC. We attempted to confirm these Results by examining the relationship between FC and incidence of abnormal MPI in patients without a prior history of coronary artery disease (CAD) who were referred for EST with MPI.   Methods:  Retrospective analysis of 3,220 consecutive patients without prior CAD referred for EST with MPI from July 1, 2007 through March 31, 2009. Patients were divided into tertiles based on estimated metabolic equivalents (METs): tertile 1:  10 METs (n= 1,085). Abnormal MPI was defined as a summed stress score (SSS) >0 or left ventricular ejection fraction (LVEF)  any  abnormalities in this population without prior CAD.   Results:  Among 3220 study patients (52% males), there were 321 abnormal MPI (154: SSS>0, 209: EF 0 and LVEF 0 without ST depression on ECG. In this group, coronary angiography was normal in 5 patients, showed obstructive CAD in 2 patients and was not performed in the others. High-risk scan (SSS>12) was present in only one patient who had a history of peripheral vascular disease.   Conclusions:  The incidence of abnormal MPI is very low in patients exercising >10METS without ST depression or chest pain, confirming previously published results. These data suggest that EST without MPI is the most appropriate initial diagnostic test in patients without prior CAD who are likely to have an excellent FC.
Prevalence and outcome of symptomatic carotid lesions in young adults
Authors: A. Carolei, C. Marini, P. Nencini, C. Gandolfo, C. Motto, E. Zanette, M. Prencipe, C. Fieschi
Journal: BMJ (1995)

To estimate the prevalence and outcome of symptomatic internal carotid artery lesions in young adults.Multicentre hospital based observational study with five year follow up.Seven neurological departments in northern and central Italy.240 patients (115 men) aged 15-44 with a recent transient ischaemic attack or stroke in the carotid territory.(a) Prevalence of symptomatic internal carotid artery stenosis or occlusion detected by continuous wave Doppler ultrasonography at entry; (b) incidence rates of cerebral, cardiac, and non-vascular death; non-fatal stroke; and non-fatal myocardial infarction.Carotid stenoses of 50-99% and occlusions were found in 38 patients (15.8%). Both conditions were significantly more frequent in patients aged over 35 and in those with hypertension, diabetes mellitus, and stroke at entry. The standardised mortality ratio at five years was 10.5 (95% confidence interval 5.0 to 19.3). Survival of patients with stenoses of 0-49% and occlusions was significantly better than that of patients with stenoses of 50-99%. Carotid stenosis of 50-99% was an independent predictor of death (hazard ratio 7.9; 95% confidence interval 2.2 to 29) and non-fatal stroke (hazard ratio 7.4; 1.5 to 37.4).The prevalence of carotid stenosis or occlusion in young adults after a cerebrovascular event is low. Though patients with high grade symptomatic carotid stenosis are at risk of non-fetal and fetal events, patients with internal artery occlusion apparently have a benign prognosis.
Application of multiplexed RT-PCR to cancer diagnosis
Authors: G. Vansant, K. Oades, G. Fogel, J. Khan, J. Monforte
Journal: Journal of Clinical Oncology (2005)

8546 Background: Global gene expression profiling by DNA microarray is being used to identify specific differences between normal and disease tissues at various stages and with various outcomes. Application of supervised statistical techniques to these data has led to the identification of small gene sets, or signatures, that provide key information for cancer diagnosis and prognosis. We have developed a practical mechanism for translating these microarray discoveries into cost-effective, quantitative clinical assays using a highly multiplexed, quantitative RT-PCR method for gene expression analysis. Methods: Universal-primed, multiplexed RT-PCR was used to analyze 33 genes in a set of 100 small, round blue-cell tumors (SRBCTs) using 20 ng of total RNA. SRBCTs represent multiple classes of tumor type including neuroblastoma, rhabdomyosarcoma, lymphoma, and Ewing family tumors, that are important pediatric cancers. SRBCTs are difficult to differentiate in routine histology, but Khan et.al. (Nature Med.,7:673–679, 2001) found that significant differences can be seen in their gene expression patterns. cDNA microarray data for 88 samples including both tissues and cell lines was analyzed using evolutionary artificial neural network models to identify a minimal diagnostic 33 gene set. These genes were incorporated into a single RT-PCR multiplex. The multiplex design uses a universal primer strategy to maximize gene number while minimizing artifacts. Data was generated in triplicate for all tumor samples. The data generated for the samples was analyzed using both neural net-derived algorithms and clustering techniques. Results: The gene expression data successfully classified 100% of the SRBCT samples according to their known disease types. Conclusions: The study demonstrated the power of multiplexed RT-PCR as a low cost and accurate tool for analyzing tumor samples, and confirms that gene expression can outperform histological methods for cancer diagnosis. No significant financial relationships to disclose.
Abstract 10882: Acute Venous Congestion Induces Local Release of Proinflammatory Cytokines and Endothelial Activation in Humans
Authors: Paolo C Colombo, Duygu Onat, Ante Harxhi, Ryan T Demmer, Yacki Hayashi, Julia Iyasere, Nir Uriel, Ann Marie Schmidt, Hani N Sabbah, Ulrich P Jorde
Journal: Circulation (2011)
Abstract 3444: The Effect of Alpha Lipoic Acid on Porcine Coronary Stent Restenosis
Authors: Myung Ho Jeong, Eun Hui Bae, Sang Yup Lim, Jae Youn Moon, Ju Han Kim, Young Keun Ahn, Young Joon Hong, Jeong Gwan Cho, Jung Chaee Kang
Journal: Circulation (2007)

Objective: We evaluated the ability of alpha lipoic acid (ALA) to affect on coronary instent restenosis (ISR) in a porcine model. Methods: In vitro experiment: We stimulated porcine VSMC using G-CSF in the presence or absence of ALA. Activation of Akt, vascular endothelial growth factor (VEGF), extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription (STAT)-3 were determined using western blot. And also, cell proliferation and migration assay were determined. In vivo experiment:Balloon overdilation injuries were performed in 2 coronary arteries in 12 pigs. Four weeks after the balloon overdilation injury, 24 bare metal stents were placed for 24 injured coronary arteries. We randomized into two groups (12 stents per group; control group: aspirin and clopidogrel only, ALA group: aspirin and clopidogrel plus 100 mg/kg ALA during 4 weeks). 16 bare metal stents were implanted randomized two coronary arteries in 8 pigs. Group I was control stent group (n=8), Group II was ALA coated stent group (n=8). Follow-up coronary angiogram (CAG) and histopathologic assessment were performed at 4 weeks after stenting. Results: G-CSF increased the phosphorylation of ERK and STAT-3, but after pretreatment of ALA, the phosphorylation of ERK and STAT-3 were significantly reduced. On histopathologic analysis, injury score, internal elastic lamina(IEL) area did not differ significantly between the two groups. The neointimal area was 7.3±0.9 mm2 in control group and 2.2±1.1 mm2 in ALA group (p&lt;0.001), and the histopathologic area of stenosis(AS) was 75.9±8.5 % in control group, 23.5±10.5 % in ALA group (p&lt;0.001). The injury score and IEL area were not significantly different between the two groups. The neointimal area was 7.4±1.1 mm2 in control group and 1.4±0.8 mm2 in ALA group (p&lt;0.001), and the AS was 77.6±10.9 % in control group, 15.6±7.6 % in ALA group (p&lt;0.001). The number of inflammatory cells within neointima was lower in ALA group (63.2±23.7 % vs. 17.6±11.6 %, p&lt;0.001). Conclusion: ALA inhibits the activation of ERK, STAT-3 and proliferation of VSMC. Both high dose of oral ALA and ALA coated stents inhibit neointimal hyperplasia in a porcine ISR model
Abstract 10093: BMI at Adolescence as an Independent Risk Factor for CHD at Adulthood - A Follow-up Study of 37,674 Teenagers
Authors: Amir Tirosh, Iris Shai, Arnon Afek, Gal Dubnov, Nir Ayalon, Barak Gordon, Estela Derazne, Dorit Tzur, Ari Shamis, Assaf Rudich
Journal: Circulation (2010)

Background: Revealing how increasing weight at adolescence versus adulthood contributes to risk of coronary heart (CHD) disease can elucidate its short-term and cumulative effects on the natural hi...
Chemotherapy does not improve quality of life in cancer patients at end of life, US study finds
Authors: Michael McCarthy
Journal: BMJ (2015)

Chemotherapy for patients with end stage cancer did not improve quality of life in those with poor or moderate performance status and worsened it in those with good performance status, US researchers have found.1

The lead author of the study, published in JAMA Oncology , was Holly G Prigerson, of the Center for Research on End of Life Care at Weill Cornell Medical College in New York City.

Participants included patients with end stage cancer and their caregivers. Patients qualified as “end stage” if they had distant metastases, disease that was refractory to one or more lines of chemotherapy, and life expectancy of six months or less. The patients had a variety of cancers including those of the lung, colon, pancreas, and breast. The 312 patients were followed prospectively until death. At enrollment 158 (50.6%) of the participants were receiving chemotherapy, and 154 (49.4%) were not. …
Anthony James Moon
Authors: Janet Squire
Journal: BMJ (2015)

Anthony James Moon (“Tony”) was educated at St Paul’s School, London. He always wanted to be a doctor, but at the time of qualifying he self diagnosed pulmonary tuberculosis, a factor that was to shape his whole professional life. Treatment then consisted of rest, and it was a full year later that he began work at the Wellhouse Hospital, London, and later the Brompton Hospital. At the Wellhouse he met his wife, Jean, a fellow doctor, and they married in 1947, the year that Tony obtained membership of the Royal College of Physicians.

Unfortunately the TB persisted, and in 1949 Tony …
Abstract 2452: A New VF Detection Method During Cardio Pulmonary Resuscitation That Minimizes Hands-off Time
Authors: Vessela Krasteva, Irena Jekova, Sarah Menetre, Todor Stoyanov, Ivan Dotsinsky, Jean-Philippe Didon
Journal: Circulation (2009)

Background: Chest compressions (CC) and Defibrillation with Automated External Defibrillator (AED) is the optimum treatment for ventricular fibrillation (VF) patients. Minimum ‘hands-off’ intervals...