tbuckley/cabot-search huggingface dataset:
Statewide Outbreak of <i>Neisseria meningitidis</i> Serogroup Y, Sequence Type 1466 — Virginia, 2022–2024
Authors: Meredith Robinson, Jenny Crain, Brittany Kendall, Victoria Alexander, Elena Diskin, Dawn Saady, Corryn Hicks, Angela Myrick-West, Paige Bordwine, Denise Sockwell, Emily Craig, Amy Rubis, Lucy McNamara, Shalabh Sharma, Rebecca Howie, Daya Marasini, Henju Marjuki, Ana Colón
Journal: MMWR Morbidity and Mortality Weekly Report (2024)

Invasive meningococcal disease (IMD) is a severe illness that can have devastating effects; outbreaks are uncommon in the United States. Vaccination is the preferred control measure for IMD outbreaks when a defined population at risk (e.g., college students or persons experiencing homelessness) can be identified. In August 2022, the Virginia Department of Health (VDH) began investigating an IMD outbreak in Virginia's Eastern Health Planning Region, prompted by the detection of four confirmed cases within 8 weeks. Clinical isolates available from three cases were characterized as Neisseria meningitidis serogroup Y, sequence type 1466. A subsequent statewide investigation identified 36 genetically related cases, including seven deaths (case fatality rate = 19.4%) as of March 1, 2024. A majority of patients (63.9%) were in an age group (30-60 years) not generally considered at increased risk for IMD; 78.0% were non-Hispanic Black or African American. No common exposures, affiliations, or risk factors were identified, and a defined population could not be identified for vaccination. VDH recommended quadrivalent (serogroups A, C, W, and Y) meningococcal conjugate vaccination of a subset of close contacts of patients based on IMD risk factors and age range similar to that of patients with identified cases. IMD outbreaks might affect populations without established IMD risk factors. Lack of a well-defined population at risk might prompt exploration of novel control strategies, such as selective vaccination of close contacts.
Tocolysis and Neurodevelopment of Children Born Very Preterm
Authors: Thibault Plouchart, Thibaut Sabatier, Jean-Baptiste Muller, Gaëlle Pinto Cardoso, Loïc Sentilhes, Jacques Bénichou, Stéphane Marret
Journal: JAMA Network Open (2024)

Neurodevelopmental outcomes of very preterm children exposed to tocolytics are not well described.
Expanding Clinical Trial Accessibility in the Digital Era With Telemedicine—Reply
Authors: Wade T. Swenson
Journal: JAMA Oncology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Strategies to Limit Benzodiazepine Use in Anesthesia for Older Adults
Authors: Mark D. Neuman, Rui Feng, Aesha S. Shukla, Xiaoyan Han, Annamarie D. Horan, Karah Whatley, Marilyn M. Schapira, Edward R. Marcantonio, Richard P. Dutton
Journal: JAMA Network Open (2024)

Despite guidelines recommending avoidance of benzodiazepine administration to older patients, many of them now receive benzodiazepines as a part of anesthesia care. The effectiveness of clinician- and patient-facing interventions to discourage such use remains insufficiently characterized.
The Way to a Patient’s Heart — Vascular Access in Cardiac Arrest
Authors: Niklas Nielsen
Journal: New England Journal of Medicine (2024)

Every year, thousands of lives are saved with cardiopulmonary resuscitation (CPR). Yet, overall survival among patients with out-of-hospital cardiac arrest is approximately 10%, even in well-performing emergency medical systems. The interventions that are undertaken at the scene of a cardiac arrest are the most likely interventions to improve outcomes: early alert, chest compressions, defibrillation, and ventilation after collapse.1 Vascular access to facilitate drug delivery has been an integral part of CPR for decades because the administration of epinephrine increases the chances of return of circulation, improves the likelihood of survival to the time of hospital admission, and is recommended in . . .
Caregiver Awareness and Knowledge of Acute Kidney Injury in Hospitalized Children
Authors: Michelle C. Starr, Julia Vanderkolk, Shrea Goswami, Cara L. Slagle, Danielle E. Soranno
Journal: JAMA Network Open (2024)

This cross-sectional analyzes knowledge of acute kidney disease (AKI) diagnosis and associated risks among caregivers of hospitalized children.
Protecting Participants in Clinical Research—Reply
Authors: Jerry Menikoff
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TMED4 facilitates Treg suppressive function via ROS homeostasis in tumor and autoimmune mouse models
Authors: Zhenyan Jiang, Huizi Wang, Xiaoxia Wang, Hongrui Duo, Yuexiao Tao, Jia Li, Xin Li, Jiamin Liu, Jun Ni, Emily Jiatong Wu, Hongrui Xiang, Chenyang Guan, Xinyu Wang, Kun Zhang, Peng Zhang, Zhaoyuan Hou, Yong Liu, Zhengting Wang, Bing Su, Bo Li, Youjin Hao, Bin Li, Xuefeng Wu
Journal: Journal of Clinical Investigation (2024)

Endoplasmic reticulum stress (ERS) plays crucial roles in maintaining regulatory T cells (Treg) stability and function, yet the underlying mechanism remains largely unexplored. Here we demonstrate that ERS-related protein transmembrane p24 trafficking protein 4 (TMED4) Treg-specific knockout (Tmed4ΔTreg) mice contain more Treg cells with impaired Foxp3 stability, Treg signature and suppressive activity, which leads to T cell hyperactivation, exacerbated inflammatory phenotype and boosted anti-tumor immunity in mice. Mechanistically, loss of Tmed4 causes defects in ERS and nuclear factor erythroid 2–related factor 2 (NRF2)-related antioxidant response, which results in excessive reactive oxygen species (ROS) that reduces Foxp3 stability and suppressive function of Treg cells in an IRE1α-XBP1 axis-dependent manner. The abnormalities can be effectively rescued by ROS scavenger, NRF2 inducer or forcible expression of IRE1α. Moreover, TMED4 suppresses IRE1α proteosome degradation via the ER-associated degradation (ERAD) system including BIP. Our study reveals that TMED4 maintains Treg cell stability and suppressive function through IRE1α-dependent ROS and the NRF2-related antioxidant response.
A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest
Authors: Keith Couper, Chen Ji, Charles D. Deakin, Rachael T. Fothergill, Jerry P. Nolan, John B. Long, James M. Mason, Felix Michelet, Chloe Norman, Henry Nwankwo, Tom Quinn, Anne-Marie Slowther, Michael A. Smyth, Kath R. Starr, Alison Walker, Sara Wood, Steve Bell, Gemma Bradley, Martina Brown, Shona Brown, Emma Burrow, Karl Charlton, Andrew Claxton Dip, Victoria Dra’gon, Christine Evans, Jakob Falloon, Theresa Foster, Justin Kearney, Nigel Lang, Matthew Limmer, Adam Mellett-Smith, Joshua Miller, Carla Mills, Ria Osborne, Nigel Rees, Robert E.S. Spaight, Gemma L. Squires, Belinda Tibbetts, Michelle Waddington, Gregory A. Whitley, Jason V. Wiles, Julia Williams, Sarah Wiltshire, Adam Wright, Ranjit Lall, Gavin D. Perkins
Journal: New England Journal of Medicine (2024)

In patients with out-of-hospital cardiac arrest, the effectiveness of drugs such as epinephrine is highly time-dependent. An intraosseous route of drug administration may enable more rapid drug administration than an intravenous route; however, its effect on clinical outcomes is uncertain.
Efficacy of Adding Veliparib to Temozolomide for Patients With <i>MGMT</i>-Methylated Glioblastoma
Authors: Jann N. Sarkaria, Karla V. Ballman, Sani H. Kizilbash, Erik P. Sulman, Caterina Giannini, Bret B. Friday, Nicholas A. Butowski, Nimish A. Mohile, David E. Piccioni, James D. Battiste, Jan Drappatz, Jian L. Campian, Sandeep Mashru, Kurt A. Jaeckle, Barbara J. O’Brien, Jesse G. Dixon, Brian F. Kabat, Nadia L. Laack, Leland S. Hu, Timothy Kaufmann, Priya Kumthekar, Benjamin M. Ellingson, S. Keith Anderson, Evanthia Galanis
Journal: JAMA Oncology (2024)

The prognosis for patients with glioblastoma is poor following standard therapy with surgical resection, radiation, temozolomide, and tumor-treating fields.
Survival Outcomes of an Early Intervention Smoking Cessation Treatment After a Cancer Diagnosis
Authors: Paul M. Cinciripini, George Kypriotakis, Janice A. Blalock, Maher Karam-Hage, Diane M. Beneventi, Jason D. Robinson, Jennifer A. Minnix, Graham W. Warren
Journal: JAMA Oncology (2024)

Smoking after a cancer diagnosis increases mortality and risk for a second cancer.
Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels
Authors: Saptarshi Sinha, Brennan W. Callow, Alex P. Farfel, Suchismita Roy, Siyi Chen, Maria Masotti, Shrila Rajendran, Johanna M. Buschhaus, Celia R. Espinoza, Kathryn E. Luker, Pradipta Ghosh, Gary D. Luker
Journal: Journal of Clinical Investigation (2024)

Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease trajectory. We modeled these interactions with tumor-MSC co-cultures and used an integrated transcriptome-proteome-network-analyses workflow to identify a comprehensive catalog of contact-induced changes. Conditioned media from MSCs failed to recapitulate genes and proteins, some borrowed and others tumor-intrinsic, induced in cancer cells by direct contact. Protein-protein interaction networks revealed the rich connectome between 'borrowed' and 'intrinsic' components. Bioinformatics prioritized one of the 'borrowed' components, CCDC88A/GIV, a multi-modular metastasis-related protein that has recently been implicated in driving a hallmark of cancer, growth signaling autonomy. MSCs transferred GIV protein to ER+ breast cancer cells (that lack GIV) through tunnelling nanotubes via connexin (Cx)43-facilitated intercellular transport. Reinstating GIV alone in GIV-negative breast cancer cells reproduced approximately 20% of both the 'borrowed' and the 'intrinsic' gene induction patterns from contact co-cultures; conferred resistance to anti-estrogen drugs; and enhanced tumor dissemination. Findings provide a multiomic insight into MSC→tumor cell intercellular transport and validate how transport of one such candidate, GIV, from the haves (MSCs) to have-nots (ER+ breast cancer) orchestrates aggressive disease states.
Protecting Participants in Clinical Research
Authors: Mark A. Rothstein, Gil Siegal
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mortality in People With Psychosis and Criminal Sanctions—Is It Time for New Approaches?
Authors: Mary F. Brunette, Stephanie A. Rolin
Journal: JAMA Network Open (2024)

Erin Spike, MD; Preeyaporn Srasuebkul, PhD; Tony Butler, PhD; Julian Trollor, MD; Jocelyn Jones, PhD; Kyllie Cripps, PhD; Grant Sara, PhD; Luke Grant, MSc; Stephen Allnutt, MBChB; David Greenberg, MMed; Peter W. Schofield, MD; Armita Adily, PhD; Nabila Zohora Chowdhury, PhD; Azar Kariminia, PhD
Vasomotor Symptom Trajectories and Risk of Incident Diabetes
Authors: Monique M. Hedderson, Emily F. Liu, Catherine Lee, Samar R. El Khoudary, Ellen B. Gold, Carol A. Derby, Rebecca C. Thurston
Journal: JAMA Network Open (2024)

This cohort study evaluates the association between frequency and trajectories of vasomotor symptoms with incident type 2 diabetes among premenopausal or perimenopausal women in the US.
Influenza and COVID-19 Vaccination Coverage Among Health Care Personnel — National Healthcare Safety Network, United States, 2023–24 Respiratory Virus Season
Authors: Jeneita Bell, Lu Meng, Kira Barbre, Emily Wong, Brynn Lape-Newman, Wilson Koech, Minn M. Soe, Austin Woods, David T. Kuhar, Matthew J. Stuckey, Heather Dubendris, Theresa Rowe, Megan C. Lindley, Elizabeth J. Kalayil, Jonathan Edwards, Andrea Benin, Hannah E. Reses
Journal: MMWR Morbidity and Mortality Weekly Report (2024)

The Advisory Committee on Immunization Practices (ACIP) recommends that health care personnel receive an annual influenza vaccine. In September 2023, ACIP recommended that everyone aged ≥6 months receive a 2023-2024 COVID-19 vaccine. Health care facilities, including acute care hospitals and nursing homes, report vaccination of health care personnel against influenza and COVID-19 to CDC's National Healthcare Safety Network (NHSN). During October 2023-March 2024, NHSN defined up-to-date COVID-19 vaccination as receipt of a 2023-2024 COVID-19 vaccine. This analysis describes influenza and 2023-2024 COVID-19 vaccination coverage among health care personnel working in acute care hospitals and nursing homes during the 2023-24 respiratory virus season (October 1, 2023-March 31, 2024). Influenza vaccination coverage was 80.7% among health care personnel at acute care hospitals and 45.4% among health care personnel at nursing homes. Coverage of 2023-2024 COVID-19 vaccination was 15.3% among health care personnel at acute care hospitals and 10.5% among health care personnel at nursing homes. Respiratory viral diseases including influenza and COVID-19 pose risks to health care personnel in U.S. health care settings, and vaccination of health care personnel is an effective strategy for maintaining a healthy workforce and improving health care system resiliency.
Mortality, Criminal Sanctions, and Court Diversion in People With Psychosis
Authors: Erin Spike, Preeyaporn Srasuebkul, Tony Butler, Julian Trollor, Jocelyn Jones, Kyllie Cripps, Grant Sara, Luke Grant, Stephen Allnutt, David Greenberg, Peter W. Schofield, Armita Adily, Nabila Zohora Chowdhury, Azar Kariminia
Journal: JAMA Network Open (2024)

Importance People living with psychosis experience excess premature mortality and are overrepresented in criminal legal systems, but little is known about mortality associated with criminal sanctions or diversion in this population. Objective To examine associations of different types of recent (past 2 years) criminal sanction, including court diversion, with mortality among people with psychosis. Design, Setting, and Participants This population-based, retrospective, data-linkage cohort study was conducted using 6 routinely collected administrative data collections from New South Wales, Australia, relating to health, court proceedings, imprisonment, and mortality. Participants (adults aged ≥18 years hospitalized for psychotic disorders) entered observation at the time of discharge from their first psychosis-related hospital admission (or their 18th birthday if aged &amp;amp;lt;18 years) between July 2001 and November 2017 and were followed-up until May 2019. Data were analyzed between February 2023 and April 2024. Exposures Recent (past 2 years) criminal sanction type, a time-varying variable with 5 categories: no recent criminal sanction, recent mental health court diversion, recent community sanction, current imprisonment, and recent prior imprisonment (ie, recent prison release). Main Outcomes and Measures Causes of death were described, and age- and sex-specific mortality rates by recent criminal sanction type were calculated. In those younger than 65 years, Cox regression was used to examine associations of all-cause and external-cause mortality with recent criminal sanction type, adjusting for sociodemographic, health-related, and offense-related confounders. Results The cohort included 83 071 persons (35 791 female [43.1%]; 21 208 aged 25-34 years [25.5%]; median [IQR] follow-up, 9.5 [4.8-14.2] years), of whom 25 824 (31.1%) received a criminal sanction. There were 11 355 deaths. In those aged younger than 65 years, recent mental health court diversion, community sanctions, and prior imprisonment were associated with increased hazards of all-cause and external-cause mortality compared with no recent sanction, with the largest adjusted hazard ratios (aHRs) observed for recent prior imprisonment (all-cause mortality: aHR, 1.69; 95% CI, 1.50-1.91; external-cause mortality: aHR, 2.64; 95% CI, 2.27-3.06). Conclusions and Relevance In this cohort study of people with psychosis, recent criminal sanctions were associated with increased mortality irrespective of sanction type. These findings suggest that future research should develop strategies to improve health and safety in people with psychosis who have criminal legal system contact.
Rare Gastric Metastasis of Lobular Type Breast Cancer Detected With 68Ga-FAPI-46 PET/CT
Authors: Elife Akgun, Omer Faruk Şahin, Mehmetcan Baloglu, Goksel Alcin, Enver Yarikkaya, Esra Arslan
Journal: Clinical Nuclear Medicine (2024)

Invasive lobular breast cancer (ILBC) is characterized with low tracer uptake on 18 F-FDG PET images. ILBC metastasis to gastrointestinal tract is a rare clinic scenario. We present a case of ILBC who presented with gastric metastasis and diagnosed with 68 Ga-FAPI-46 PET/CT and 18 F-FDG PET/CT images.
Extranodal Mantle Cell Lymphoma Presented as Bilateral Adrenal Masses on 18F-FDG PET/CT and 68Ga-DOTATATE PET/CT
Authors: Nuh Filizoglu, Salih Ozguven, Tunc Ones, Halil Turgut Turoglu, Tanju Yusuf Erdil
Journal: Clinical Nuclear Medicine (2024)

Mantle cell lymphoma (MCL) is a rare type of B-cell non-Hodgkin lymphoma that commonly presents with constitutional symptoms, lymphadenopathy, and laboratory abnormalities. Although less common, extranodal involvement of MCL may be seen at initial presentation and most commonly occurs in the spleen, liver, bone marrow, and gastrointestinal tract. Adrenal involvement in MCL is extremely rare, and only a few cases have been reported in the literature. Herein, we present 18F-FDG PET/CT and 68Ga-DOTATATE PET/CT findings of a unique case of primary extranodal MCL with gastric and adrenal involvement.
Routine Vaccination Coverage — Worldwide, 2023
Authors: Camille E. Jones, M. Carolina Danovaro-Holliday, George Mwinnyaa, Marta Gacic-Dobo, Lauren Francis, Jan Grevendonk, Yoann Nedelec, Aaron Wallace, Samir V. Sodha, Ciara Sugerman
Journal: MMWR Morbidity and Mortality Weekly Report (2024)

In 2020, the World Health Assembly endorsed the Immunization Agenda 2030 (IA2030), a 10-year strategy to reduce vaccine-preventable disease (VPD)-associated morbidity and mortality. IA2030 goals include improving equitable vaccination coverage, halving the number of unimmunized (zero-dose) children, and increasing the introduction of new and underutilized vaccines. The COVID-19 pandemic disrupted health systems worldwide, hindering years of childhood vaccination achievements and putting global public health goals at risk. This report presents trends in World Health Organization (WHO) and UNICEF routine vaccination coverage estimates through 2023 across the 194 WHO member countries. During 2022-2023, global coverage with the first and third doses of diphtheria-tetanus-pertussis-containing vaccine (DTPcv) (89% and 84%, respectively) and the first dose of measles-containing vaccine (83%) stagnated and remained lower than prepandemic levels. The 31 WHO member countries with fragile, conflict-affected, and vulnerable (FCV) settings include approximately one half of the world's 14.5 million children who did not receive the first DTPcv dose. The introduction of new and underutilized vaccines, such as a second MCV dose in the African Region, has improved countries' overall protection against VPDs. Accelerating country-specific routine immunization and catch-up vaccination programs to reach unvaccinated and incompletely vaccinated children, especially those living in FCV settings, is critical to reducing morbidity and mortality associated with VPDs.
Radiation Pneumonitis With 99mTc-MDP Uptake in a Patient With Breast Cancer
Authors: Mohammad Hadi Samadi, Susan Khezri, Faeze Rabani Banou, Mina Bai, Somaye Barashki
Journal: Clinical Nuclear Medicine (2024)

Abstract We present MDP bone scan findings of radiation pneumonitis in a 45-year-old woman with invasive ductal carcinoma of the right breast, classified as stage IIIa, T3N2M0. The patient underwent a modified radical mastectomy, neoadjuvant chemotherapy, and subsequent radiotherapy, receiving the last session 7 months before the bone scan. Whole-body images acquired 3 hours postinjection of 20 mCi (730 MBq) 99m Tc-MDP showed incidentally increased uptake in the right hemithorax, confined to the lung parenchyma of the right lung on SPECT/CT images.