Rare and Common Genetic Variation Underlying Atrial Fibrillation Risk
Authors: Oliver B. Vad, Laia M. Monfort, Christian Paludan-Müller, Konstantin Kahnert, Søren Z. Diederichsen, Laura Andreasen, Luca A. Lotta, Jonas B. Nielsen, Alicia Lundby, Jesper H. Svendsen, Morten S. Olesen, Aris Baras, Gonçalo Abecasis, Adolfo Ferrando, Michael Cantor, Giovanni Coppola, Andrew Deubler, Aris Economides, Luca A Lotta, John D Overton, Jeffrey G Reid, Alan Shuldiner, Katherine Siminovitch, Jason Portnoy, Marcus B Jones, Lyndon Mitnaul, Alison Fenney, Jonathan Marchini, Manuel AR Ferreira, Maya Ghoussaini, Mona Nafde, William Salerno, Christina Beechert, Erin D Brian, Laura M Cremona, Hang Du, Caitlin Forsythe, Zhenhua Gu, Kristy Guevara, Michael Lattari, Alexander Lopez, Kia Manoochehri, Prathyusha Challa, Manasi Pradhan, Raymond Reynoso, Ricardo Schiavo, Maria S Padilla, Chenggu Wang, Sarah E Wolf, Amelia Averitt, Nilanjana Banerjee, Dadong Li, Sameer Malhotra, Justin Mower, Mudasar Sarwar, Deepika Sharma, Jeffrey C Staples, Sean Yu, Aaron Zhang, Muhammad Aqeel, George Mitra, Sujit Gokhale, Andrew Bunyea, Krishna P Punuru, Sanjay Sreeram, Gisu Eom, Benjamin Sultan, Rouel Lanche, Vrushali Mahajan, Eliot Austin, Sean O'Keeffe, Razvan Panea, Tommy Polanco, Ayesha Rasool, Xiaodong Bai, Lance Zhang, Boris Boutkov, Evan Edelstein, Alexander Gorovits, Ju Guan, Lukas Habegger, Alicia Hawes, Olga Krasheninina, Samantha Zarate, Adam J Mansfield, Evan K Maxwell, Suganthi Balasubramanian, Suying Bao, Kathie Sun, Chuanyi Zhang, Vikhna Raj Kumar Karuppaiya, Joshua Backman, Kathy Burch, Adrian Campos, Lei Chen, Sam Choi, Amy Damask, Liron Ganel, Sheila Gaynor, Benjamin Geraghty, Arkopravo Ghosh, Salvador R Martinez, Christopher Gillies, Lauren Gurski, Joseph Herman, Eric Jorgenson, Tyler Joseph, Michael Kessler, Jack Kosmicki, Nan Lin, Adam Locke, Priyanka Nakka, Karl Landheer, Olivier Delaneau, Anthony Marcketta, Joelle Mbatchou, Arden Moscati, Aditeya Pandey, Anita Pandit, Charles Paulding, Jonathan Ross, Carlo Sidore, Eli Stahl, Maria Suciu, Timothy Thornton, Peter VandeHaar, Sailaja Vedantam, Scott Vrieze, Jingning Zhang, Rujin Wang, Kuan-Han Wu, Bin Ye, Blair Zhang, Andrey Ziyatdinov, Yuxin Zou, Kyoko Watanabe, Mira Tang, Frank Wendt, Brian Hobbs, Jon Silver, William Palmer, Rita Guerreiro, Amit Joshi, Antoine Baldassari, Cristen Willer, Sarah Graham, Ernst Mayerhofer, Mary Haas, Niek Verweij, George Hindy, Jonas Bovijn, Tanima De, Parsa Akbari, Luanluan Sun, Olukayode Sosina, Arthur Gilly, Peter Dornbos, Juan Rodriguez-Flores, Moeen Riaz, Manav Kapoor, Gannie Tzoneva, Momodou W Jallow, Anna Alkelai, Ariane Ayer, Veera Rajagopal, Sahar Gelfman, Vijay Kumar, Jacqueline Otto, Neelroop Parikshak, Aysegul Guvenek, Jose Bras, Silvia Alvarez, Jessie Brown, Jing He, Hossein Khiabanian, Joana Revez, Kimberly Skead, Valentina Zavala, Jae S Sul, Esteban Chen, Michelle G LeBlanc, Jason Mighty, Nirupama Nishtala, Nadia Rana, Jennifer Rico-Varela, Jaimee Hernandez, Randi Schwartz, Jody Hankins, Samuel Hart, Ann Perez-Beals, Gina Solari, Johannie Rivera-Picart, Michelle Pagan, Sunilbe Siceron, Adam Buchanan, David J. Carey, Christa L. Martin, Michelle Meyer, Kyle Retterer, David Rolston
Journal: JAMA Cardiology (2024)

Atrial fibrillation (AF) has a substantial genetic component. The importance of polygenic risk is well established, while the contribution of rare variants to disease risk warrants characterization in large cohorts.