tbuckley/cabot-search huggingface dataset:
A role of somatostatin and its receptor, SSTR4, in the migration of hepatic oval “stem” cells
Authors: Youngmi Jung, Seh-Hoon Oh, Bryon E. Petersen
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4362 

Somatostatin (SST) is a regulatory peptide that activates G protein-coupled receptors comprised of five members (SSTRs 1-5). Recently it has been demonstrated that SST can act as a chemoattractant for hematopoietic precursor cells. We hypothesized that SST could be a chemoattractant for hepatic oval cell (HOC)s by stimulating somatostatin receptor (SSTRs). Reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot assay showed an increased expression of SST in the 2-acetyl-aminofluorene (2AAF)/partial hepatectomy (PHx) HOC induction model. Immunohistochemical staining revealed the expression of SST in 2AAF/PHx-treated rat liver, as compared to normal liver. RT-PCR results showed that SSTR1, 2, 4, and 5 expression were up-regulated in HOCs, as compared to normal hepatocytes and liver. However, SSTR4 was the only subtype expressed exclusively by HOCs. Gene expression for SSTR4 determined by quantitative real-time PCR showed a significant increase during HOC activation, peaking approximately seven days post PHx. Western blot assay and immunohistochemical staining confirmed the expression of SSTR4 by HOCs. Proliferation and BrdU incorporation assays demonstrated that SST did not affect the proliferation of HOCs, while the migration assay established that SST could exert chemotactic effect for HOCs, and this function was abrogated by pretreatment with anti-SSTR4 antibody. SST stimulated the rearrangement of actin filaments in HOCs, whereas reorganization of actin filaments was not observed in non-treated or anti-SSTR4 antibody-treated HOCs. In addition, the increased phosphorylation of AKT and PAK1 was observed in SST-treated HOCs. However, this phosphorylation was decreased when HOCs were pretreated with anti-SSTR4 antibody. These data demonstrate that SST induces the migration of HOCs through SSTR4, and this effect appears to be mediated via the PI3 kinase/ AKT/PAK1 signaling pathway.
Fatal Car Trunk Entrapment Involving Children--United States, 1987-1998
Authors: A P Hart, R E Zumwalt, P J McFeeley, B Marchant, T C Grey, G Rohanna, E Darby, S Hill, M Day
Journal: JAMA (1999)

From July-August 1998, at least 11 U.S. children died in 3 instances of car trunk entrapment. This report provides a summary of these 3 incidents, describes characteristics of car trunk entrapment incidents involving children since 1987, and reviews measures to prevent children from becoming trapped in car trunks. Findings indicate that at least 9 incidents of fatal car trunk entrapment involving children occurred during 1987-98, that all incidents occurred in hot weather and involved children aged less than or equal to 6 years, and that these deaths were preventable.
First isolation and outbreak of OXA-48-producing Klebsiella pneumoniae in an Irish hospital, March to June 2011
Authors: D J O’Brien, C Wrenn, C Roche, L Rose, C Fenelon, A Flynn, V Murphy, S F FitzGerald, L E Fenelon, B Crowley, K Schaffer
Journal: Eurosurveillance (2011)

Five OXA-48-producing Klebsiella pneumoniae were detected in a tertiary referral hospital in Ireland between March and June 2011. They were found in the clinical isolates of five cases that were inpatients on general surgical wards. None of the cases had received healthcare at a facility outside of Ireland in the previous 12 months. This is the first report of OXA-48-producing K. pneumoniae in Ireland.
Traffic-Related Air Pollution and Parkinson’s Disease in Denmark: A Case–Control Study
Authors: Beate Ritz, Pei-Chen Lee, Johnni Hansen, Christina Funch Lassen, Matthias Ketzel, Mette Sørensen, Ole Raaschou-Nielsen
Journal: Environmental Health Perspectives (2015)

Very little is currently known about air pollutants' adverse effects on neurodegenerative diseases even though recent studies have linked particulate exposures to brain pathologies associated with Parkinson's and Alzheimer's disease.In the present study, we investigated long-term exposure to traffic-related air pollution and Parkinson's disease.In a case-control study of 1,696 Parkinson's disease (PD) patients identified from Danish hospital registries and diagnosed 1996-2009 and 1,800 population controls matched by sex and year of birth, we assessed long-term traffic-related air pollutant exposures (represented by nitrogen dioxide; NO2) from a dispersion model, using residential addresses from 1971 to the date of diagnosis or first cardinal symptom for cases and the corresponding index date for their matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated with logistic regression, adjusting for matching factors and potential confounders.We found ambient air pollution from traffic sources to be associated with risk of PD, with a 9% higher risk (95% CI: 3, 16.0%) per interquartile range increase (2.97 μg/m(3)) in modeled NO2. For participants living for ≥ 20 years in the capital city, ORs were larger (OR = 1.21; 95% CI: 1.11, 1.31) than in provincial towns (OR = 1.10; 95% CI: 0.97, 1.26), whereas there was no association among rural residents.Our findings raise concerns about potential effects of air pollution from traffic and other sources on the risk of PD, particularly in populations with high or increasing exposures.
MUCIN IN THE TREATMENT OF PEPTIC ULCER ASSOCIATED WITH RENAL AND HEPATIC DISEASE
Authors: Andrew B. Rivers, Frances R. Vanzant
Journal: Annals of Internal Medicine (1934)

Article1 March 1934MUCIN IN THE TREATMENT OF PEPTIC ULCER ASSOCIATED WITH RENAL AND HEPATIC DISEASEANDREW B. RIVERS, M.D., F.A.C.P., FRANCES R. VANZANT, M.D.ANDREW B. RIVERS, M.D., F.A.C.P.Search for more papers by this author, FRANCES R. VANZANT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-9-1122 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe usefulness of mucin in the treatment of peptic ulcer has been widely discussed for several years. The efficacy of this substance as a therapeutic agent is assumed to depend largely on its diluent and neutralizing effect on gastric acidity, and on its ability to protect gastrointestinal tissues locally against the proteolytic action of the acid gastric chyme. That it has some virtue in the treatment of peptic ulcer is strongly suggested by the brilliant results obtained by Fogelson,1Atkinson,2Brown3and other investigators. Our5experience with mucin has not been equally successful; nevertheless the striking results occasionally obtainable even...References1. FOGELSON SJ: Treatment of peptic ulcer with gastric mucin; preliminary report, Jr. Am. Med. Assoc., 1931, xcvi, 673-675. CrossrefGoogle Scholar2. ATKINSON AJ: Gastric mucin in the treatment of peptic ulcer, Jr. Am. Med. Assoc., 1932, xcviii, 1153-1156. CrossrefGoogle Scholar3. BROWNCROMERJENKINSONGILBERT CFSPELNC: Mucin therapy for peptic ulcer: preliminary report of objective results on patients with intractable ulcer, Jr. Am. Med. Assoc., 1932, xcix, 98-100. CrossrefGoogle Scholar4. FOGELSON SJ: Clinical experiences in the treatment of peptic ulcer with gastric mucin, Illinois Med. Jr., 1932, lxii, 516-520. Google Scholar5. RIVERSVANZANTESSEX ABFRHE: Dangers of using impure mucin in the treatment of peptic ulcer, Jr. Am. Med. Assoc., 1932, xcviii, 1156. CrossrefGoogle Scholar6. HARDTRIVERS LLAB: Toxic manifestations following alkaline treatment of peptic ulcer, Arch. Int. Med., 1923, xxxi, 171-180. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Submitted for publication May 22, 1933.From the Division of Medicine, The Mayo Clinic, Rochester, Minnesota, and the University Hospital, Minneapolis, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1934Volume 7, Issue 9Page: 1122-1125KeywordsHospital medicinePeptic ulcersRenal diseases ePublished: 1 December 2008 Issue Published: 1 March 1934 PDF downloadLoading ...
Abstract MP053: Coronary Calcium on Standard Chest CT and Cardiovascular Disease Death in Community-Living Individuals
Authors: Katherine J Blair, Matthew Allison, Cindy Morgan, Christina L Wassel, Dena E Rifkin, Michael H Criqui, Joachim H Ix
Journal: Circulation (2012)

CAC on EBCT by the Agatston method predicts incident CVD events but is not covered by most insurances. Standard chest CT scans are done for many clinical indications. Shemesh et.al. recently proposed a simple CAC scoring system using standard chest CTs but correlations with Agatston CAC on EBCT and associations with CVD events in community-living populations is unknown. Methods: 4,544 consecutive out-patients presented for elective CT scanning including EBCT for CAC and a standard chest CT for lung disease in 2000-03. Participants were followed through 2009; death certificates classified cause of death. In this nested case-control study, we identified cases of CVD death (n=56) and age/sex matched each with 3 controls. EBCT CAC was scored by Agatston method. Using the standard chest CTs, the 3 major coronary arteries and left main were scored from 0-3 (0, no calcium; 1, &lt;1/3; 2, 1/3-2/3; or 3, &gt;2/3 calcified) and scores were summed (0-12; Shemesh score). Conditional logistic regression determined the odds of CVD death by each score separately. Results: Mean age was 72 yrs; 26% were women. The intra-reader and inter-reader kappa (any vs. 0) were 0.90 and 0.76 on 19 randomly selected scans. The median (IQR) Agatston CAC score were 315 (101, 1024) and 202 (5, 794) in cases and controls (P&lt;0.05), whereas the corresponding median (IQR) Shemesh score were 3 (2, 4) and 2 (1, 3) (P&lt; 0.05). The correlation of Agatston and Shemesh scores was 0.72 (p&lt; 0.001). When adjusted for traditional CVD risk factors, the OR (95%CI) for CVD death per 1 SD greater Ln(CAC+1) was 1.57 (1.00-2.46) by Agatston on EBCT, and 1.66 (1.03-2.68) by Shemesh on standard chest CT. The odds of CVD death associated with any CAC vs. none was 2.23 (0.67-7.40) by Agatston, and 2.38 (0.81-6.97) by Shemesh. Conclusions: A simple CAC scoring system using standard chest CT is strongly correlated with Agatston CAC on EBCT and provides similar prediction of CVD death in community-living individuals.
Krysolgan in the Treatment of Lupus Erythematosus: Report on Twenty-eight Cases
Authors: William H. Goeckerman
Journal: Annals of Internal Medicine (1928)

Article1 November 1928Krysolgan in the Treatment of Lupus Erythematosus: Report on Twenty-eight CasesWILLIAM H. GOECKERMAN, M.D.WILLIAM H. GOECKERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-5-428 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the treatment of lupus erythematosus it is probably too much to expect that any one method will act as a specific in all form of the disease, although it can be said without hesitation that since the disease is the result of an internal toxic process, its attack by the internal and systemic route is more logical than by any local application. Many drugs have been used in the former manner, but only a few, and these probably not very effective, have attained reasonable popularity. Since the gold preparations were first used about fifteen years ago, they have gained...1 SchambergWright JFCS: The use of gold and sodium thiosulphate in the treatment of lupus erythematosus. Arch. Dermat. and Syph., 1927, xv, 119-137. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Section on Dermatology and Syphilology The Mayo Clinic Rochester, Minnesota*Submitted for publication April 26, 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWilliam H. GoeckermanWilliam H. Goeckerman (1884–1954) 1 November 1928Volume 2, Issue 5Page: 428-434KeywordsDrugsLupus erythematosusSystemic lupus erythematosus ePublished: 1 December 2008 Issue Published: 1 November 1928 PDF downloadLoading ...
Weekend versus Weekday Urine Collections in Assessment of Stone-Formers
Authors: Richard W Norman
Journal: Journal of the Royal Society of Medicine (1996)

Twenty-four-hour urine collections are an important part of the metabolic evaluation of stone-formers, but are difficult for patients at work. At weekends the results might be different. Forty-five stone-formers who worked at day jobs from Monday to Friday collected urine for 24 h on a normal working day and also on a Saturday or Sunday and the differences were evaluated. Average 24 h urine volume was higher on weekdays than at weekends. Calcium, oxalate, and uric acid excretion did not differ. These results imply an increased risk of crystalluria at the weekend. Therefore weekend collections are most likely to show abnormalities and should be acceptable to clinicians.
Abstract 3495: Improvement in Stroke Work Index and Stroke Volume Index, the Most Powerful Serial Hemodynamic Variables in Cardiogenic Shock Complicating Acute Myocardial Infarction, Should not Delay Early Revascularization: A Report from the SHOCK Trial
Authors: Raban Jeger, April M Lowe, Judith S Hochman, Christopher E Buller, Vladimir Dzavik, John G Webb, Matthias E Pfisterer, Thierry H LeJemtel, Ulrich P Jorde
Journal: Circulation (2006)
Can or Will the Internist Practice Preventive Medicine?
Authors: George H. Bigelow
Journal: Annals of Internal Medicine (1929)

Article1 November 1929Can or Will the Internist Practice Preventive Medicine?GEORGE H. BIGELOWGEORGE H. BIGELOWSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-5-492 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the presence of the clinician the health officer is apt to feel a self-conscious gratitude; "gratitude" because of the satisfaction that comes from mingling with those in the more established and time honored branches of the profession; "self-conscious" because many of the profound social, economic and medical readjustments with which the doctor is faced are blamed on the health officer and his ilk. But it is important that such mingling should not only be allowed but encouraged, in order that each may understand the profound difference of their points of view. The doctor must use every resource to protect... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Mass.*Presented before the Boston meeting of the American College of Physicians, April 11, 1929. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1929Volume 3, Issue 5Page: 492-494KeywordsGratitudeHealth economicsPreventive medicine Issue Published: 1 November 1929 PDF downloadLoading ...
Abstract 9491: Prognostic Implications of Right Ventricular Longitudinal Peak Systolic Strain on Long-Term Outcome in Patients with Pulmonary Hypertension
Authors: Marlieke L Haeck, Roderick W Scherptong, Nina Ajmone Marsan, Eduard Holman, Hubert W Vliegen, Martin J Schalij, Jeroen J Bax, Victoria Delgado
Journal: Circulation (2011)

Purpose: The performance of the right ventricle (RV) is an important prognostic marker in patients with pulmonary hypertension (PH). Two-dimensional speckle tracking strain analysis allows angle independent evaluation of RV systolic function. The aim of this study was to assess the prognostic value of RV longitudinal peak systolic strain (LPSS) on the long-term survival in patients with pulmonary hypertension of all aetiologies. Methods: One-hundred fifty patients with PH of all aetiologies (age 59±15 yrs; NYHA 2.56±0.68; mean systolic artery pressure 62±20 mmHg) were analyzed. RV LPSS was assessed by 2-dimensional speckle tracking echocardiography at baseline. All cause mortality was noted during follow-up. Results: During a mean follow-up of 2.7±1.8 years, 37 (26%) patients had died. The study population was divided according to the value of -19% RV LPSS. Both groups of patients were comparable in terms of age, gender, LV ejection fraction, WHO PH group and systolic artery pressure. Patients with RV LPSS ≥ -19% had significant lower TAPSE (16±4 mm vs. 18±4 mm, p&lt;0.001), RV FAC (32±13% vs 37±9%, p=0.027), larger RV diastolic area (23±7 vs. 20±5, p=0.008) and worse NYHA functional class (2.7±0.6 vs. 2.3±0.8, p=0.003). Kaplan-Meier curve demonstrated a significant worse survival in patients with RV LPSS ≥ -19% (figure 1, log-rank p=0.002). After multivariate correction, RV LPSS ≥ -19% was significantly associated to all-cause mortality (HR 3.36, 95% CI 1.13-9.96, p=0.029). Conclusions: RV LPSS is associated with long-term survival of patients with pulmonary hypertension of all aetiologies. RV LPSS may be a valuable parameter to risk stratify these patients.
Abstract 67: Inhibition of Myocardial Apoptosis by Postconditioning Is Associated with Attenuation of Oxidative Stress-Mediated NF{kappa}B Translocation and Cytokine Release
Authors: Hajime Kin, Ning-Ping Wang, James Mykytenko, James Reeves, Jeremiah Deneve, Rong Jiang, Amanda J. Zatta, Robert A Guyton, Jakob Vinten-Johansen, Zhi-Qing Zhao
Journal: Circulation (2006)

Background: Oxidative stress stimulated-NFκB activation has been associated with rapid transcription of cytokines and induction of apoptosis. This study tested the hypothesis that postconditioning ...
Emergency Pericardiocentesis
Authors: Michael T. Fitch, Bret A. Nicks, Manoj Pariyadath, Henderson D. McGinnis, David E. Manthey
Journal: New England Journal of Medicine (2012)

The use of emergency pericardiocentesis to aspirate fluid in patients with cardiac tamponade can be a lifesaving procedure that restores normal cardiac function and peripheral perfusion. This video demonstrates the procedure.
Abstract 14770: Latent Right Ventricular Myocardial Dysfunction in Patient With Heart Failure With Preserved Ejection Fraction and Preclinical Diastolic Dysfunction
Authors: Hiroki Oe, Satoko Ugawa, Norihisa Toh, Yuko Oono, Nobuhiro Nishii, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Morita, Hiroshi Ito
Journal: Circulation (2013)
Resectability after two different chemotherapy regimens: results of the first step of a phase II randomised trial in initially resectable stage I-IIIa non-small cell lung cancer conducted by the European Lung Cancer Working Party
Authors: Philippe Lothaire, Thierry Berghmans, Jean-Jacques Lafitte, Vicente Giner, M.C. Berchier, Anne-Pascale Meert, Marianne Paesmans, Paul Mommen, Vincent Ninane, Jean-Paul Sculier
Journal: European Respiratory Journal (2003)
Two hours iv infusion of 2-chlorodeoxyadenosine (2-CDA) in hairy cell leukemia (HCL) is effective and may produce less CD34/CD8 ratio impairment. Results from the HOVON-23 study
Authors: J.M.M. Raemaekers, M.B. van 't Veer, G.E.G. Verhoef, P.C. Huijgens, B. de Bock, R.H.J. van Oers, R. Marwijk-Kooy, J. Bogman
Journal: Blood (1995)
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia
Authors: Tetsuichi Yoshizato, Bogdan Dumitriu, Kohei Hosokawa, Hideki Makishima, Kenichi Yoshida, Danielle Townsley, Aiko Sato-Otsubo, Yusuke Sato, Delong Liu, Hiromichi Suzuki, Colin O. Wu, Yuichi Shiraishi, Michael J. Clemente, Keisuke Kataoka, Yusuke Shiozawa, Yusuke Okuno, Kenichi Chiba, Hiroko Tanaka, Yasunobu Nagata, Takamasa Katagiri, Ayana Kon, Masashi Sanada, Phillip Scheinberg, Satoru Miyano, Jaroslaw P. Maciejewski, Shinji Nakao, Neal S. Young, Seishi Ogawa
Journal: New England Journal of Medicine (2015)

In patients with acquired aplastic anemia, destruction of hematopoietic cells by the immune system leads to pancytopenia. Patients have a response to immunosuppressive therapy, but myelodysplastic syndromes and acute myeloid leukemia develop in about 15% of the patients, usually many months to years after the diagnosis of aplastic anemia.
Revised Declaration of Helsinki
Authors: A. A Hyder, D. Human, F. Crawley, C. IJsselmuiden, P. A Singer, S. R Benatar
Journal: BMJ (2001)

Editor—Singer and Benatar's editorial on revisions of the Declaration of Helsinki proposes “capacity development,” defined as an increased number of professionals trained in ethics.1 Although this is indeed a step that needs to be taken, I cannot agree that it alone will advance the cause of ethical research, especially with the plans that the authors propose.

The assumption that having more trained people will change the system satisfies a necessary but not sufficient criterion. The fact that there are more doctors in the developing world today than there were 20 years ago does not mean either that the practice of medicine is better or that health needs are addressed. It depends on what these people trained in ethics do, where they do it, how they sustain their efforts, and how they integrate their contributions within the overall health development of nations.

The numbers and budgets presented in the proposal are simply arbitrary—they are not defended and so are difficult to evaluate. If $100m is available, what are the alternative pathways for investment for the developing world? If one considers all the health and staffing needs then the need for ethics training may not be the most important: community health workers, trained birth attendants, and others may be higher on the list. Another major issue is where the money goes. Implicit in the editorial is that the money will have to go to training centres in the West. This means that 90% of the money is not going to the developing world—a feature of “aid” well known to those in the South.

The editorial severely underplays the role of other stakeholders. The importance of roles for professionals from a wide variety of disciplines, of decision makers, of community leaders, and of business leaders in shaping the practice of ethics in the South needs to be recognised. A “global alliance for health ethics” and the proposed influence on the World Bank and World Trade Organisation are only distant visions. Is this the most effective or most efficient way to achieve that vision? Activists, lobbyists, and social scientists will beg to differ.

As long as ethics is viewed as something that is only for ethicists, or for those who have only been trained, it will never have the profound influence we all hope that it will have in both the developing and developed world.