tbuckley/cabot-search huggingface dataset:
Impact of physical therapy techniques and common interventions on sleep quality in patients with chronic pain: A systematic review
Authors: Santiago Navarro-Ledesma, Dina Hamed-Hamed, Ana Gonzalez-Muñoz, Leo Pruimboom
Journal: Sleep Medicine Reviews (2024)

This systematic review aims to find effectful healthcare strategies, with special focus on drug-free interventions and physical therapy, as part of the treatment for sleep in patients with chronic musculoskeletal pain. Data search was conducted across seven scientific databases. This review is deposited in the Prospero International prospective register of systematic reviews (CRD42023452574). Seventeen RCTs from different healthcare fields complied with our inclusion criteria. Two RCTs investigated manual therapy, five RCTs therapeutic exercise, one RCT Fu's subcutaneous needling, two RCTs physical agents (one on balneotherapy and one on cryo-stimulation), two RCTs cognitive-behavioral therapy, and four RCTs pharmacological therapy and their effect on sleep quality and/or quantity in patients suffering from chronic pain. We included the four RCT's in this systematic review with the purpose to be able to compare natural interventions with allopathic ones. As allopathic interventions are more prone to have secondary negative effects than physical therapy, compare the two types of interventions could be in favor of choosing the most effective treatment with the least secondary negative effects. Additionally, two RCTs on neurofeedback and limbic neuromodulation were also included. The results of the included studies suggest that strategies such as manual therapy, therapeutic exercise, Fu's subcutaneous needling, balneotherapy, cryo-stimulation, neurofeedback, limbic neuromodulation, cognitive-behavioral therapy, and pharmacological therapies have positive effects on patients suffering from chronic pain and sleep disturbances, especially when they suffer musculoskeletal pain. Secondary negative effects were found for the possible overuse of certain medicines such as morphine, a huge problem in the United States. Sleep deficiency is an independent risk factor for many diseases, including chronic pain syndrome and therefore more studies are needed to find non-toxic interventions for people suffering sleep disorders associated with systemic diseases and pain.
Abstract 10947: Geometric Changes of Mitral Valve Before and After Successful Mitral Valve Repair Surgery: A Quantitative Analysis Using Real-Time Three-dimensional Transoesophageal Echocardiography
Authors: Sung-Ji Park, Su-Jin Kim, Ji-Hyn Kil, Kye Taek Ahn, Sung-A Chang, Jin-Oh Choi, Sang-Chol Lee, Seung Woo Park, Jae K. Oh
Journal: Circulation (2011)
Multiomics Analysis of PCB126’s Effect on a Mouse Chronic-Binge Alcohol Feeding Model
Authors: Tyler C. Gripshover, Banrida Wahlang, Kimberly Z. Head, Jianzhu Luo, Oluwanifemi E. Bolatimi, Melissa L. Smith, Eric C. Rouchka, Julia H. Chariker, Jason Xu, Lu Cai, Timothy D. Cummins, Michael L. Merchant, Hao Zheng, Maiying Kong, Matthew C. Cave
Journal: Environmental Health Perspectives (2024)

Environmental pollutants, including polychlorinated biphenyls (PCBs) have been implicated in the pathogenesis of liver disease. Our group recently demonstrated that PCB126 promoted steatosis, hepatomegaly, and modulated intermediary metabolism in a rodent model of alcohol-associated liver disease (ALD).
Tetracyclines enhance antitumor T-cell immunity via the Zap70 signaling pathway
Authors: Mari Tone, Kota Iwahori, Michinari Hirata, Azumi Ueyama, Akiyoshi Tani, Jun-Ichi Haruta, Yoshito Takeda, Yasushi Shintani, Atsushi Kumanogoh, Hisashi Wada
Journal: Journal for ImmunoTherapy of Cancer (2024)

Cancer immunotherapy including immune checkpoint inhibitors is only effective for a limited population of patients with cancer. Therefore, the development of novel cancer immunotherapy is anticipated. In preliminary studies, we demonstrated that tetracyclines enhanced T-cell responses. Therefore, we herein investigated the efficacy of tetracyclines on antitumor T-cell responses by human peripheral T cells, murine models, and the lung tumor tissues of patients with non-small cell lung cancer (NSCLC), with a focus on signaling pathways in T cells.
A bidirectional model of sleep and technology use: A theoretical review of How much, for whom, and which mechanisms
Authors: Serena Bauducco, Meg Pillion, Kate Bartel, Chelsea Reynolds, Michal Kahn, Michael Gradisar
Journal: Sleep Medicine Reviews (2024)

The link between technology and sleep is more complex than originally thought. In this updated theoretical review, we propose a new model informed by the growing body of evidence in the area over the past 10 years. The main theoretical change is the addition of bi-directional links between the use of technology and sleep problems. We begin by reviewing the evidence to date for the originally proposed mechanisms of bright light, arousal, nighttime sleep disruptions, and sleep displacement. Then, in support of the new direction of effect (sleep problems preceding technology use), we propose two new mechanisms: technology before sleep might be used as a time filler and/or as an emotional regulation strategy to facilitate the sleep-onset process. Finally, we present potential moderators of the association between technology and sleep, in recognition of protective and vulnerability factors that may mitigate or exacerbate the effects of technology on sleep and vice versa. The goal of this theoretical review is to update the field, guide future public health messages, and to prompt new research into how much technology and sleep affect each other, for whom it may be problematic, and which mechanisms may explain their association.
NIR-responsive copper nanoliposome composites for cascaded ferrotherapy via ferroptosis actived ICD and IFN-γ released
Authors: Junrui Wang, Wenli Zhang, Zhuoyan Xie, Xingyue Wang, Jiangshan Sun, Fei Ran, Weixi Jiang, Yun Liu, Zhigang Wang, Haitao Ran, Dajing Guo
Journal: Biomaterials (2024)
European Association of Urology/European Society for Paediatric Urology Guidelines on Paediatric Urology: Summary of the 2024 Updates
Authors: Michele Gnech, Allon van Uitert, Uchenna Kennedy, Martin Skott, Alexandra Zachou, Berk Burgu, Marco Castagnetti, Lisette't Hoen, Fardod O'Kelly, Josine Quaedackers, Yazan F. Rawashdeh, Mesrur Selcuk Silay, Guy Bogaert, Christian Radmayr
Journal: European Urology (2024)
Orthotopic Robot-assisted Kidney Transplantation: Surgical Technique and Preliminary Results
Authors: Francesc Vigués, Begoña Etcheverry, José I. Perez Reggeti, Josep Maria Gaya, Angelo Territo, Andrea Gallioli, Camille Berquin, Giuseppe Basile, José F. Suárez, Maria Fiol, Oscar Buisan, Lluís Riera, Thomas Prudhomme, Nicolas Doumerc, Alessio Pecoraro, Alberto Breda
Journal: European Urology (2024)
Gram-negative bacteria recognition and photodynamic elimination by Zn-DPA based sensitizers
Authors: Zuokai Wang, Shuang Zeng, Yifu Hao, Wenlin Cai, Wen Sun, Jianjun Du, Saran Long, Jiangli Fan, Jingyun Wang, Xiaoqiang Chen, Xiaojun Peng
Journal: Biomaterials (2024)
Environmentally sustainable opportunities for health systems: metered-dose inhaler prescribing, dispensing, usage, and waste at The Ottawa Hospital
Authors: Carolanne Caron, Shellyza Sajwani, Katherine Bateman, Owen Degenhardt, Mathilde Gaudreau-Simard, Smita Pakhale, Salmaan Kanji
Journal: The Lancet Planetary Health (2024)

<h2>Abstract</h2><h3>Background</h3> The carbon footprint of Canada's health sector is among the worst in the world, responsible for 4·6% of Canada's total greenhouse gas emissions. A quarter of emissions from Canada's health sector are linked to pharmaceuticals, including metered dose inhalers (MDIs). MDIs use propellants, such as hydrofluorocarbons, which act as greenhouse gas emissions and contribute to the health-care sector's overall carbon footprint. The objective of this study was to describe MDI prescribing, dispensing, usage, and waste patterns at The Ottawa Hospital (Ottawa, ON, Canada). Secondary objectives included estimating the monetary and carbon cost of current practice and the potential benefits and costs of switching to the more environmentally friendly dry powder inhalers. <h3>Methods</h3> In this retrospective point-prevalence cohort study, we identified 100 consecutive patients from medical and surgical services at both campuses of The Ottawa Hospital from health records discharged from medical and surgical services and who were prescribed at least one MDI during their admission. Medical records were reviewed and data related to demographics, MDI prescribing, dispensing, usage, and wastage were collected using a pre-piloted electronic case report form. Financial cost was calculated using local costing estimates and carbon cost was calculated using published estimates. <h3>Findings</h3> Between Jan 1, 2023, and June 1, 2023, we collected data for 100 eligible patients, of whom 60 (60%) were female and 90 (90%) were admitted to hospital medicine wards (10% from surgical wards). The median length of stay was 7 (range 1–47) days. The most common inpatient diagnoses were respiratory tract infections in 43 (43%) of 100 patients and chronic obstructive pulmonary disease exacerbations in 28 (28%) of 100 patients. The median number of MDIs prescribed during a patients stay was two (range one to 15) and the median number dispensed was one (range one to seven). For formulary options of MDIs, of the 200 (range 30–1400) actuations dispensed per patient, 8% were used, representing 92% wastage. During the audit, 315 MDIs were dispensed in total, of which 97 were not used at all. <h3>Interpretation</h3> MDIs are significant contributors to the carbon footprint attributed to pharmaceutical use in hospitals. This study suggests that 90% of MDI doses are wasted, showing that there is substantial room for improvement. <h3>Funding</h3> None.
Association of early-life exposure to air and noise pollution with youth mental health: findings from the ALSPAC cohort
Authors: Joanne B Newbury, Jon Heron, James B Kirkbride, Andrew Boyd, Richard Thomas, Stanley Zammit, Helen L Fisher, Ioannis Bakolis
Journal: The Lancet Planetary Health (2024)

BackgroundIncreasing evidence suggests that air pollution exposure contributes to the development of mental health problems, including psychosis and depression. However, little is known about the importance of early-life exposure, nor the potential role of noise pollution, a correlate of air pollution. We examined the association of exposure to air and noise pollution from pregnancy to age 12 years with three mental health problems assessed at ages 12, 18, and 24 years.MethodsData were from the Avon Longitudinal Study of Parents and Children (ALSPAC), which tracks the development of about 14 000 babies who had expected delivery dates between April 1, 1991, and Dec 31, 1992, in Avon, UK. This was linked with novel data on nitrogen dioxide, PM2·5, and noise pollution in pregnancy, childhood (ages 1–9 years), and adolescence (ages 10–12 years). Psychotic experiences, depression, and anxiety were measured at ages 12, 18, and 24 years. Logistic regression models were controlled for individual-level, family-level, and area-level confounders, and e-values were calculated to estimate residual confounding.FindingsParticipants exposed to higher PM2.5, particularly during pregnancy, had greater odds for psychotic experiences (adjusted odds ratio 1·17 [95% CI 1·05–1·30]) and depression (1·11 [1·01–1·22]). There was little evidence associating nitrogen dioxide or noise pollution with psychotic experiences or depression. Conversely, higher nitrogen dioxide (but not PM2·5) exposure in pregnancy (1·16 [1·01–1·33]), and higher noise pollution in childhood (1·20 [1·06-1·37]) and adolescence (1·17 [1·02-1·35]), were associated with greater odds for anxiety.InterpretationOur study builds on evidence linking air pollution to psychosis and depression and provides rare longitudinal evidence linking noise pollution to anxiety. Our findings indicate that air pollution exposure earlier in development (eg, during pregnancy) might be particularly important, and suggest a degree of specificity in terms of pollutant-outcome associations. If causal, our findings suggest that interventions to reduce air pollution would improve global mental health.FundingWellcome Trust, UK Medical Research Council–Wellcome, and University of Bristol.
Coming together as a whole: lessons from connecting across sectors, cultures, and contexts to elevate efforts for planetary health
Authors: Margot Parkes, Angel Kennedy, Tannis Reynolds, Jonathan Doyon, Diana Kutzner
Journal: The Lancet Planetary Health (2024)

<h2>Abstract</h2><h3>Background</h3> Addressing complex and interconnected ecological, social, and health issues necessitates upstream, solutions-oriented, and whole-systems thinking. Specifically, exploring what it means to live in reciprocity with the planet and all living systems, now and for generations to come, can have a crucial role in advancing planetary health. <h3>Methods</h3> In this presentation, we show findings from four gatherings that we co-designed and co-hosted to connect communities, lands, waters, climate, and health. We draw lessons from two events in the Cowichan watershed (co-hosted by Cowichan Tribes) and the Stellako and Nechako watersheds (co-hosted by Stellat'en First Nation) that were co-designed with the ECHO Network. These gatherings brought together youth, Indigenous leaders, researchers, and health, community, and environmental decision-makers across British Columbia to learn how to address connected health, environmental, and community concerns. We supplement these findings with insights from two co-hosted conversations, that connected five continents and more than 40 countries, each enabling 24 h of continuous dialogue on the theme of working together for a healthy, just, and sustainable planet. <h3>Findings</h3> Gatherings took place between Oct 12, 2022, and Dec 1, 2023. These gatherings each provided lessons about how Indigenous-led, integrative approaches that connect the health of people to lands, waters, and ecosystems can elevate and enhance our work and scholarship to address ecological, social, and health issues. Specifically, initiatives co-designed in this way help overcome challenges that arise when addressing boundary-crossing, intersectional and intersectoral issues at the nexus of climate, public health, and planetary health. Our findings include insights into strengthening research and public health capacity for integrative approaches to complex issues that are relevant to place-based contexts and have implications and applications for planetary health. <h3>Interpretation</h3> Our presentation summarises how these gatherings—each of which were fuelled by a sense of love for the planet, each other, and future generations—have progressed intersectoral, intergenerational, boundary-crossing, and transformative approaches to planetary health. These insights help guide future directions for planetary health research, practice, and policy. <h3>Funding</h3> The Canadian Institute of Health Research Environment (IP4150712), Michael Smith Health Research BC (RA-2022-2872), and Vancouver Foundation (FOI19-1781).
Fostering planetary health in polluted environments: lessons from the Xonacatlán Indigenous Council in Mexico
Authors: Carlos E Sanchez-Pimienta
Journal: The Lancet Planetary Health (2024)

<h2>Abstract</h2><h3>Background</h3> The communities of El Salto and Juanacatlán face negative impacts on human and ecosystem health due to their proximity to the second-largest industrial area in Mexico. Despite living in a region negatively impacted by high levels of pollution, these communities have organised to foster planetary health by reforesting with native plants, campaigning to stop further industrial development, and founding the Xonacatlán Indigenous Council (XIC) to reclaim traditional ways of living. This research project seeks to advance insights on the implications of fostering planetary health from the perspective of communities facing adverse socioeconomic and environmental conditions. <h3>Methods</h3> This qualitative study draws from participatory action research, Indigenous storywork, and ethnography. The XIC acted as the community advisory board of this research project and two XIC members are part of the research team. We investigate whether the stories and practices of community members associated with XIC contribute to fostering planetary health. Research activities will include 40–60 participants in storytelling interviews, story-making workshops, and participant observation in XIC activities. Data collection started on Nov 20, 2023, and will be finalised in August, 2024. <h3>Findings</h3> Our ethnographic analysis investigates local understandings of the relationships between human and ecosystem health. Anticipated findings include stories about the rejection of narratives of industrial progress due to environmental damage, the reconnection with Coca identities and traditional ways of relating to the land, and the use of direct action to counteract the negligence of the state-sponsored public health system and assert local planetary health needs. <h3>Interpretation</h3> By assessing grassroots Coca Indigenous action as a site of collective expertise on planetary health, we expect that this research project will bring attention to how people living in polluted environments can inform the conceptual development of planetary health and expand the range of practical initiatives that are considered fundamental to sustaining human and ecosystem life. <h3>Funding</h3> None.
Heat literacy and adaptation among semi-rural community in Malaysia
Authors: Syahrul Nellis, Min Thu, Mohd Roshidi Ismail, Sandra Barteit, Darwin Gouwanda, Till Bärnighausen, Tin Tin Su
Journal: The Lancet Planetary Health (2024)

<h2>Abstract</h2><h3>Background</h3> Heatwaves present health risks globally but there is limited evidence on how temperature perceptions affect activities. This study aimed to examine community perceptions of heat as a potential health hazard and ascertain the current heat protection measures of the residents of the South East Asia Community Observatory (SEACO) in Malaysia. <h3>Methods</h3> In this longitudinal study, we randomly selected community members aged between 18 and 70 years who resided in Segamat district of Johor state, Malaysia. Over 21 days, we conducted three home visits to each participant. During each visit, participants completed a questionnaire consisting of Likert scale, multiple choice, and free text questions and we collected quantitative and qualitative data. These inquiries assessed the participants' perception of heat as health threat, whether or not they took heat preventive measures, and the specific protective measures they routinely employed. Descriptive data analyses were conducted and patterns of protective measures were investigated. <h3>Findings</h3> Between March 29 and July 31, 2023, 120 participants (72 women and 48 men) completed 360 questionnaires over three home visits. Initially, 58% participants recognised heat hazards to daily activities, decreasing to 42% and 35% by visits 2 and 3. Participants took preventive measures throughout the day, which was consistently high between 1200 h and 1400 h, with 77% of participants taking preventive measures on visit 1, 82% on visit 2, and 82% on visit 3. Use of preventive measures was also high between 1400 h and 1730 h, with 77% using preventive measure on visit 1, 81% on visit 2, and 79% on visit 3. The most common protective measures were fans (used by 68–88% of participants), drinking more water (70–78% of participants), and resting (44–72% of participants). The least common were relocating to cooler places, removing clothes, and using wet towels (0–2·5%). Despite high temperatures, perceptions of heat risks decreased over time. Participants took basic protections, especially at midday, but improved literacy and affordable cooling options are needed to protect vulnerable rural populations. <h3>Interpretation</h3> Our findings underline the need to improve heat literacy and adaptation as only half of the population assessed perceived heat as a potential health hazard and practised limited heat protective measures. Addressing climate change and health necessitates fundamental behavioural changes on the part of individuals and communities, to protect them against the adverse effects of heat. <h3>Funding</h3> Monash University Malaysia and Heidelberg Institute of Global Health, Heidelberg University.
Integrating health, nutrition, and environmental impacts of foods: a life cycle impact assessment and modelling analysis of foods in Canada
Authors: Sarah Jarvis, Michalis Hadjikakou, Jason Wu, Michael Classens, Laura Chiavaroli, John Sievenpiper, Mary L'Abbe, David Jenkins, Vasanti Malik
Journal: The Lancet Planetary Health (2024)

<h2>Abstract</h2><h3>Background</h3> Given the urgency of transitioning towards sustainable nutrition, dietary shifts that provide co-benefits to human health and the environment are imperative. There is currently no database of the environmental impacts of foods that reflects Canada's unique geographical and agri-climatic context and regional inputs and emissions. To determine sustainable diets, harmonising nutritional considerations with environmental impacts is also essential for an equitable comparison of foods. We aimed to develop a Canadian Food Life Cycle Inventory database and a multidimensional index to enable a joint assessment of the health and environmental impacts of foods in Canada. <h3>Methods</h3> The Canadian Food Life Cycle Inventory database uses life cycle assessment methodology to evaluate environmental impacts. The datasets mirror Canada's food consumption patterns, averaging the spectrum of agricultural practices weighted by domestic production and import shares. The database is structured according to the nomenclature and categorisation of the Canadian Nutrient File. Environmental sustainability is assessed using a cradle-to-grave approach, including indicators such as greenhouse gas emissions, eutrophication, particulate matter, freshwater usage, land use, non-renewable energy consumption, and food loss and waste. Environmental impacts are quantified through an environmental impact score (EIS) assigned to each impact category for a given food. The EIS-nutrition (EIS-N) integrates the evaluation of nutritional quality with environmental impacts using Nutri-Score, a validated food nutrient-profiling tool. The EIS-N is modelled as a ratio of the EIS to the Nutri-Score values. <h3>Findings</h3> Preliminary results show the greatest environmental impacts for animal-based foods, particularly beef, in agreement with current literature. Foods with greater nutritional quality also generally show greater environmental sustainability, with some exceptions for particular impact categories. <h3>Interpretation</h3> The database and index have potential to serve as powerful tools to support researchers, policy makers, and consumers, harnessing big data to drive efficient food and climate solutions for systems transformation. <h3>Funding</h3> Province of Ontario and University of Toronto, CIHR SMART Healthy Cities Training Platform, and University of Toronto's Temerty Faculty of Medicine.