tbuckley/cabot-search huggingface dataset:
Abstract 5135: Carbon Monoxide Promotes Neovascularization After Myocardial Infarction by Modulating the Expression of Angiogenic Cytokines and Growth Factors
Authors: Paivi Lakkisto, Juha-Matti Siren, Katariina Immonen, Hanna Forsten, Ville Kytö, Heli Segersvärd, Liisa-Maria Voipio-Pulkki, Mika Laine, Kari Pulkki, Ilkka Tikkanen
Journal: Circulation (2009)

Carbon monoxide is a biologically active molecule produced endogenously by heme oxygenase-1 (HO-1). Many of the beneficial properties of HO-1 are mediated by CO, but the role of CO in cardiac regeneration has not been studied earlier. Male Wistar rats were given the direct CO-donor methylene chloride (MC, 500 mg/kg, po, −3h, n=60). Control animals received no pretreatment (n=60). Rats were subjected to LAD ligation or sham-operation and sacrificed at 1 day, 3 days, 1 week and 4 weeks after ligation. Cardiac regeneration was assessed by immunohistochemistry and confocal microscopy. Stem cell and angiogenesis related gene expression was studied using real-time RT-PCR arrays. Compared to control hearts, CO significantly increased the accumulation of c-kit+/sca-1−/CD34− cells into the infarct area at weeks 1 (0.47±0.1 vs. 0.18±0.06 c-kit+ cells/mm2, p&lt;0.05) and 4 (12.4±6.8 vs. 0.14±0.06 c-kit+ cells/mm2, p&lt;0.001) post-MI. A substantial part of these c-kit+ cells (41%) were positive for the smooth muscle transcription factor GATA6 whereas only few Ets-1+ endothelial lineage committed cells were found. CO also increased vascular density in the infarct area at week 4 (395±24 vs. 306±25 α -SMA+ vessels/mm2, p&lt;0.05). Interestingly, the number of large arteries was most significantly increased (7.1±0.6 vs. 4.8±0.4 α -SMA+ vessels/mm2, p&lt;0.01). However, CO had no effect on capillary density. In the PCR array analysis, significantly increased expression of angiogenic cytokines and growth factors, including SDF-1, Hif-1 α , HGF, IGF-1, IL6 and CXCL2, was found in the infarct areas of CO-donor pretreated hearts compared to control MI hearts (p&lt;0.05). In conclusion, CO upregulates the expression of angiogenic cytokines and growth factors, thereby activating c-kit+ stem cells and promoting neovascularization in the infarcted hearts.
Abstract 2754: Aortic Valve Area on 64-Slice Computed Tomography Strongly Correlates with Transesophageal Echocardiography in Aortic Stenosis
Authors: Troy LaBounty, Baskaran Sundaram, Prachi Agarwal, William Armstrong, Ella A Kazerooni, Elina Yamada
Journal: Circulation (2007)

Objective: The purpose of this study was to assess the ability of multidetector computed tomography (MDCT) to determine aortic valve area (AVA) in patients with aortic stenosis. Methods: Transesoph...
Abstract 4845: Hypertrophic Cardiomyopathy due to Sarcomere Gene Mutations is Associated with More Severe Derangement of Microvascular Function Compared to Myofilament Negative Disease
Authors: Iacopo Olivotto, Francesca Girolami, Michael J Ackerman, Roberto Sciagra, Stefano Nistri, J. M Bos, Barbara Sotgia, Francesca Torricelli, Paolo G Camici, Franco Cecchi
Journal: Circulation (2008)

Coronary microvascular dysfunction (CMD) is an important primary feature of hypertrophic cardiomyopathy (HCM), contributing to myocardial ischemia and ventricular remodelling, and is predictive of adverse outcome. Whether there is any association between presence/severity of CMD and HCM’s pathogenic substrate remains to be determined. To address this issue, we used positron emission tomography (PET) to assess CMD in an HCM cohort that received comprehensive genetic testing for sarcomeric/myofilament-HCM. We measured maximum (intravenous dipyridamole, 0.56 mg/kg) myocardial blood flow (Dip-MBF), using 13 N-labeled ammonia and PET in 46 HCM patients (age 38±14 years, 32 male). Genetic testing was performed by denaturing high performance liquid chromatography and automatic DNA sequencing of nine myofilament-encoding genes including both thick filament proteins (myosin binding protein C, beta-myosin heavy chain, regulatory and essential light chains); and thin filament proteins (troponin-T, troponin-I, troponin-C, alpha-tropomyosin and alpha-actin). Results . Thirty-four mutations were identified in 30/46 patients (myofilament-HCM; 65%), including 29 with thick filament and 6 with thin filament mutations, as well as 4 with complex genotype. Despite similar age and clinical features, patients with myofilament-HCM showed lower Dip-MBF values than the patients with a negative genetic test (1.6±0.7 versus 2.2±0.9 ml/min/g, respectively; p=0.03). Specifically, 13/30 (43%) patients with myofilament-HCM had a Dip-MBF below the lower tertile for the study group (≤1.38 ml/min/g), compared to 2/16 (12%) patients with a negative genetic test (p=0.034). No difference in Dip-MBF was evident with respect to the particular sarcomeric gene involved (ANOVA p=0.63). HCM due to sarcomere gene mutations is characterized by more severe impairment in microvascular function compared to myofilament negative disease, irrespective of the involved contractile protein. These findings suggest that sarcomeric mutations might be implicated in adverse remodelling of the microcirculation in patients with HCM, and account for the greater prevalence of ventricular dysfunction and failure in this subset.
Lessons of the Gacaca
Authors: Jesse M. Raiten
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improved Detection of Cardiac Allograft Vasculopathy
Authors: Steven J. Kindel, Yuk M. Law, Clifford Chin, Michael Burch, James K. Kirklin, David C. Naftel, Elizabeth Pruitt, Michael P. Carboni, Anna Arens, Andrew M. Atz, William J. Dreyer, William T. Mahle, Elfriede Pahl
Journal: Journal of the American College of Cardiology (2015)
Linkage analysis for major histocompatibility complex-related genetic susceptibility in familial chronic lymphocytic leukemia.
Authors: Stephen Bevan, Daniel Catovsky, Estella Matutes, Petar Antunovic, Martin J. Auger, Isaac Ben-Bassat, Andrew Bell, Alain Berrebi, Elizabeth J. Gaminara, Maria E. Júnior, Francesca R. Mauro, Klas Quabeck, Saad M. B. Rassam, Cecil Reid, Isabel Ribeiro, Pinhas Stark, Jacques J. M. van Dongen, Jennifer Wimperis, Susan Wright, Andrea Marossy, Martin R. Yuille, Richard S. Houlston
Journal: Blood (2000)
Abstract 3477: Prognostic Value and Serial Changes of Plasma Adiponectin Concentration in Patients With Chronic Heart Failure. Data From the GISSI-HF Trial
Authors: Serge Masson, Torbjorn Omland, Roberto Latini, Allan Flyvbjerg, Valentina Milani, Jan Frystyk, Angiolina Pasini, Patrizio Sarto, Tarcisio Vago, Aldo P Maggioni, Gianni Tognoni, Luigi Tavazzi
Journal: Circulation (2009)
Cocaine abuse among schizophrenic patients
Authors: K Brady, R Anton, J C Ballenger, R B Lydiard, B Adinoff, J Selander
Journal: American Journal of Psychiatry (1990)

Initial studies have indicated that stimulant abuse is prevalent among schizophrenic persons. To assess the phenomenon of cocaine abuse by patients with schizophrenia, 17 male cocaine-abusing schizophrenic patients were compared with 22 male schizophrenic patients who did not use cocaine. The cocaine-abusing subjects had been hospitalized more frequently, were more likely to be of the paranoid subtype, and were more likely to be depressed at the time of interview. It appears that cocaine abuse may influence both the psychopathologic presentation of schizophrenic patients and the intensity of care that they require.
Abstract 4186: Magnetic Resonance Late Enhancement in Dilated Cardiomyopathy is Related with Complex Ventricular Arrhythmias
Authors: Ana G Almeida, João S Marques, Luis M Sargento, Cláudio David, Nuno C Dias, Mário G Lopes
Journal: Circulation (2008)

Late enhancement (LE) by cardiovascular magnetic resonance (CMR) has been found in about two-thirds of patients with dilated cardiomyopathy (DCM). However, the functional significance of this finding is not well established. The aim of this study was to assess, in patients (pts) with DCM, the relationship of LE with complex ventricular arrhythmias. Methods: 38 consecutive pts (44±8 years-old, 26 men) with DCM were included, after exclusion of ischemic heart disease by coronary angiography and secondary cardiomyopathies by clinical and laboratory investigation. Functional class and plasmatic NT-pro-BNP were assessed. All underwent CMR: short-axis SSFP encompassing all LV; LV volumes and ejection fraction (EF) were obtained; LE (segmented inversion-recovery fast gradient-echo sequence), 10 –15 mn after 0.2mmol/kg of Gd-DTPA acquired in 2, 3, 4-chambers and short-axis views; LE was classified in subendocardial or midwall and quantified using plannimetry of LE contours, 6SD from remote myocardium; a fibrosis index was obtained from LE mass/myocardial mass. All underwent 24 H Holter monitoring, less than one month from CMR, and the number of ventricular arrhythmias (pairs, triplets or ventricular tachycardia) assessed. Results: 22 pts were in NYHA class II and 17 in class III. Mean NT-pro-BNP was 512 ± 134 pg/ml, LV end-diastolic volume was 161±35mL/m2, mean EF was 31 ± 8%. LE was found in 26 patients (68%) and was always present in the midwall, involving a mean of 8 segments per patient (range 3–13); septal and anterior walls were the most frequently involved. There were repetitive ventricular arrhythmias in 29 pts. In comparison with pts without LE, pts with LE had higher NT-pro-BNP (917 vs 431 pg/ml, p=0.001), larger LV end-diastolic volumes (173 vs 143ml/m2, p=0.001) and lower EF (26% vs35%, p=0.001) and higher number of complex ventricular arrhythmias (p=0,0004). No relationship was found between the fibrosis index and the number of arrhythmias. Using multivariate analysis, the presence of LE was an independent predictor of ventricular arrhythmias (/p=0.002). Conclusion: In patients with DCM, LE is significantly associated and an independent predictor of complex ventricular arrhythmias among LV volumes, ejection fraction and NT-pro-BNP,
Abstract 2764: The Advantages of using Multi-slice Spiral Computed Tomography to Evaluate Serious Coronary Complications in Adolescents after Kawasaki Disease
Authors: Hiroshi Kanamaru, Kensuke Karasawa, Rie Ichikawa, Osamu Abe, Michio Miyashita, Kazuo Taniguchi, Mamoru Ayusawa, Naokata Sumitomo, Tomoo Okada, Yuichi Sato, Kensuke Harada, Hideo Mugishima
Journal: Circulation (2007)

Objectives We identified novel multi-slice spiral computed tomography (MSCT) findings in adolescents after Kawasaki disease that could not be detected by coronary angiography (CAG). Methods We studied 18 patients who had suffered from serious coronary arterial lesions after Kawasaki disease (mean age: 21.7 years; range: 13 to 34 years). Seventeen patients had stenotic lesions, and all had coronary aneurysms. MSCT was performed using a Siemens SOMATOM Volume Zoom (4-detector row) or a Toshiba Aquillion 16 (16-detector row). The detection of coronary calcification, stenotic lesion, and intimal hypertrophy was applied to all coronary arteries in MSCT and compared to CAG. Results Of the 18 patients, there were 11 (61%) in whom novel findings were detected by MSCT. Coronary calcifications were found in 11 of the 18 patients (61%) by MSCT. Five patients had concentric calcified aneurysms, 4 had eccentric calcified aneurysms, and the other 2 had mixed calcified aneurysms. Coronary stenotic lesions were present in 6 of the 18 patients (33%) with calcified aneurysms. There were 2 patients who had intimal hypertrophy (11%). One patient had intimal hypertrophy along the left main trunk with a giant calcified aneurysm along the left anterior descending artery. Two patients had severe stenoses just distal to giant calcified aneurysms that were regarded as false positive findings, which were identified as mild stenoses by CAG. Conclusions MSCT offers advantages over CAG in the evaluation of calcified aneurysms and intimal hypertrophy, and has the potential to become a diagnostic modality for coronary intervention in adolescents after Kawasaki disease.
Abstract 16235: Impact of Long-term Adherence to {beta}-blocker Therapy on Survival in Statin-treated Patients after AMI: Should Current Practice Guidelines be Revisited?
Authors: Nicolas Danchin, Anke Neumann, Philippe Tuppin, Alain Weill, Christine De Peretti, Philippe Ricordeau, Hubert Allemand
Journal: Circulation (2010)

Background and aim: Trials of beta-blockers in post-AMI patients have been performed at a time when reperfusion therapy or statin treatment were not used. The aim of this study was to assess the pr...
Abstract 10141: Plasma Trans-Fatty Acids Are Higher in African American than Non Hispanic White Persons with Type 2 Diabetes Independent of Dietary Sources of Trans-Fatty Acids
Authors: Dawn C Schwenke, John P Foreyt, Edgar R Miller, Rebecca Reeves, Mara Vitolins
Journal: Circulation (2011)

Explanations for race/ethnic disparities in cardiovascular diseases risk in persons with type 2 diabetes are not yet understood. Trans-fatty acids (TFA) increase cardiovascular disease risk but dat...
P0786 : 100% SVR12 with ledipasvir/sofosbuvir±ribavirin for 12 weeks in Japanese patients with chronic genotype 1 hepatitis C virus who previously failed therapy with protease inhibitor + pegylated interferonα + ribavirin
Authors: M. Omata, T. Takehara, O. Yokosuka, N. Sakamoto, M. Korenagai, H. Mochizuki, K. Nakane, H. Enomoto, M. Yanase, H. Toyoda, F. Ikeda, T. Genda, T. Umemura, H. Yatsuhashi, T. Ide, N. Toda, K. Nirei, Y. Ueno, Y. Nishigaki, S. De-Oertel, B. Gao, H. Dvory-Sobol, A. Ishizaki, M. Omote, P.S. Pang, S.J. Knox, W.T. Symonds, J.G. McHutchison, N. Izumi, M. Mizokami
Journal: Journal of Hepatology (2015)
First clinical results of licofelone (ml3000), an inhibitor of COX-1, COX-2 and 5-LOX, for the treatment of osteoarthritis
Authors: Jean-Yves Reginster, P. Bias, A. Buchner
Journal: Annals of the Rheumatic Diseases (2002)

full series of preclinical studies. The GI, renal, hepatic and general tolerability was excellent. In clinical phase II and phase III studies in patients with osteoarthritis the efficacy/tolerability profile was studied in comparison with placebo and active treatment. Methods: In an endoscopic study, 121 subjects with normal gastric and duodenal mucosa were treated for 4 weeks with licofelone 200 mg bid or 400 mg bid, placebo or naproxen 500 mg bid. The mucosa was evaluated with modified Lanza scores. Ulcers (3 mm or more in diameter) were assessed. In another study, 148 patients with OA were treated for 12 weeks with licofelone 200 mg bid or naproxen 500 mg bid. Efficacy was evaluated using the WOMAC index. Responders were defined to show a 30% improvement versus baseline. Results: In the endoscopic study, the gastric mucosa was completely normal after 4 weeks in 93% (200 mg bid), 89% (400 mg bid), 90% (placebo) and 37% (naproxen) of subjects. No ulcers were present in either licofelone group or the placebo group. In the naproxen group 6 ulcers (20%) were observed (5 GU, 1 DU). In the 12-week study the efficacy of licofelone 200 mg bid was comparable or slightly better than in the naproxen group. With licofelone, the mean WOMAC index was improved by 23.3 mm (VAS) and with naproxen there was an improvement by 21.5 mm. For the WOMAC index, 69.4% of licofelone-treated patients were reponders (68.4% with naproxen). GI adverse events were reported by 13.9% (licofelone) and by 26.3% (naproxen) of patients. Conclusion: Treatment of OA patients with Licofelone was shown to have a comparable efficacy as conventional NSAIDs but to have an excellent GI and general tolerability. The combined inhibition of both COX-isoenzymes and of 5-LOX avoids the obvious disadvantages of selective COX-2 inhibitiors (e.g. thromboembolic risk) but spares also the GI mucosa. Phase III clinical studies are already completed. The innovative mechanism of action may offer a new alternative for the treatment of OA with an optimal benefit/ risk ratio. Osteoarthritis Clinical aspects and treatment 2
Abstract 11633: Association of Cardiac Valve Calcification and C-Reactive Protein with Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients - 10-Year Follow-Up Study from Induction of Hemodialysis Therapy
Authors: Furuhashi Kyuichi, Ishii Hideki, Takahashi Hiroshi, Aoyama Toru, Kamoi Daisuke, Kawamura Yoshihiro, Murohara Toyoaki
Journal: Circulation (2011)

Background: Cardiac valve calcification is frequently seen in patients with end-stage renal disease (ESRD), and may potentially reflect systemic atherosclerosis. Serum C-reactive protein (CRP) is a...
The Progress of Preventive Medicine
Authors: E L Blackmun
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Posttraumatic stress disorder in survivors of the Brooklyn Bridge shooting
Authors: B Trappler, S Friedman
Journal: American Journal of Psychiatry (1996)

The authors documented the frequency of posttraumatic stress disorder (PTSD) in civilian victims of urban terrorism.A recent shooting attack on a van of Hasidic students provided a unique opportunity to document responses of survivors in this targeted group. Eleven of 14 survivors were compared with age-matched subjects on a variety of questionnaires and clinical evaluations.Of the 11 survivors, four were diagnosed with PTSD (all of whom also had concurrent major depressive disorder), one with major depressive disorder, and two with adjustment disorder.Findings are interpreted in the context of unique factors contributing to the heightened vulnerability of this group.
Abstract 2445: Dynamic Change and Pivotal Role of Myeloid-Related Protein (MRP) 8 and MRP14 in Acute Kawasaki Disease
Authors: Keiichi Hirono, Dirk Foell, Yanling Xing, Sachiko Miyagawa-Tomita, Fei Ye, Kazuhiro Watanabe, Sayaka Watanabe, Keiichirou Uese, Makoto Nakazawa, Fukiko Ichida, Johannes Roth, Toshio Miyawaki
Journal: Circulation (2006)

Background: Myeloid-related protein (MRP) 8 and MRP14, which are S100-proteins secreted by activated neutrophils and monocytes, bind specifically to endothelial cells, and induce thrombogenic and i...
Genetic and epigenetic regulation of two imprinted tumor suppressor genes - ARHI and PEG3 - in ovarian cancer
Authors: Weiwei Feng, Rebecca T. Marquez, Zhen Lu, Jinsong Liu, Karen H. Lu, Yinhua Yu, Robert C. Bast
Journal: Cancer Research (2006)

1573   Genomic imprinting plays an important role in mammalian development, growth, cell differentiation and carcinogenesis. Imprinted tumor suppressor genes may be particularly important in the pathogenesis of ovarian cancer where strong chemical or viral carcinogens have not been implicated. In this study, we have documented decreased expression, CpG island hypermethylation and LOH for two imprinted tumor suppressor genes, ARHI and PEG3, in human ovarian cancers. Expression was measured by real time RT-PCR, methylation was quantitated by pyrosequencing and LOH was detected by electrophoresis and allele scoring with intragenic TA repeats and other polymorphic markers in 10 ovarian cancer cells lines, 42 pairs of normal and ovarian cancer tissues from the same patients, 3 normal ovarian epithelial cell cultures and epithelial scrapings from 5 normal ovaries. ARHI was downregulated in 8 of 10 ovarian cancer cell lines and 72.5% of 40 evaluable cases. As an imprinted gene, both CpG islands of the ARHI promoter were partially methylated in all normal ovarian epithelial cells and normal tissues. ARHI CpG island I and II were hypermethylated in 28.6% and 10% cases of ovarian cancers respectively. ARHI expression was reduced in 11 of 12 cases (91.7%) of ovarian cancer with CpG island I hypermethylation, and all 4 cases with CpG island II hypermethylation. LOH was found in 8 of 35 (23%) informative cases. The 4 cases with CpG island II hypermethylation had LOH, suggesting that hypermethylation and silencing could result from loss of the functional paternal allele. PEG3 expression was downregulated in 6 of 10 ovarian cancer cell lines and in 77.5% of 40 evaluable ovarian cancer cases. As a maternally imprinted gene, PEG3 was partially methylated in all normal ovarian epithelial cells. PEG3 was hypermethylated in 8 of 10 ovarian cancer cell lines and 31% of 42 ovarian cancers; 2 ovarian cancer cases (4.76%) were hypomethylated. PEG3 expression was downregulated in 12 of 13 hypermethylated cases (92.31%). In 25 informative cases, we found LOH in 5 cases (20%). PEG3 expression was downregulated in 4 of these 5 cases. Thus, a majority of ovarian cancers had downregulation of two imprinted tumor suppressor genes. Aberrant methylation and loss of heterozygosity were associated with decreased expression of these genes.