tbuckley/cabot-search huggingface dataset:
Diet and Survival in Black Women With Epithelial Ovarian Cancer
Authors: Tsion A. Armidie, Elisa V. Bandera, Courtney E. Johnson, Lauren C. Peres, Kristin Haller, Paul Terry, Maxwell Akonde, Edward S. Peters, Michele L. Cote, Theresa A. Hastert, Lindsay J. Collin, Michael Epstein, Jeffrey Marks, Melissa Bondy, Andrew B. Lawson, Anthony J. Alberg, Joellen M. Schildkraut, Bo Qin
Journal: JAMA Network Open (2024)

Importance Ovarian cancer survival among Black women is the lowest across all racial and ethnic groups. Poor dietary quality also disproportionately affects Black populations, but its association with ovarian cancer survival in this population remains largely unknown. Objective To examine associations between dietary patterns and survival among Black women diagnosed with epithelial ovarian cancer (EOC). Design, Setting, and Participants This prospective cohort study was conducted among self-identified Black women aged 20 to 79 years newly diagnosed with histologically confirmed EOC in the African American Cancer Epidemiology Study (AACES) between December 2010 and December 2015, with follow-up until October 2022. AACES is a population-based study of ovarian cancer risk and survival among Black women in 11 US regions. Data were analyzed from March 2023 to June 2024. Exposures Dietary patterns were assessed by the Healthy Eating Index-2020 (HEI-2020) and Alternative Healthy Eating Index-2010 (AHEI-2010), with scores calculated based on dietary intake in the year prior to diagnosis and collected via the validated Block 2005 Food Frequency Questionnaire. Higher scores indicate better dietary quality. Main outcomes and measures Hazard ratios (HRs) and 95% CIs were estimated from multivariable Cox models for the association between adherence to dietary recommendations and overall mortality among all participants and those with high-grade serous ovarian cancer (HGSOC). Results Among 483 Black women with EOC (mean [SD] age, 58.1 [10.5] years), 310 deaths were recorded during a median (IQR) follow-up of 4.3 (2.0-8.2) years. No association of dietary patterns with mortality was found among women with EOC overall. However, among 325 women with HGSOC, better adherence to HEI-2020 was associated with decreased mortality in later quartiles compared with the first quartile (HR, 0.63; 95% CI, 0.44-0.92 for quartile 2; HR, 0.67; 95% CI, 0.46-0.97 for quartile 3; HR, 0.63; 95% CI, 0.44-0.91 for quartile 4 ). Similar results were observed with AHEI-2010 among women with HGSOC for the second (HR, 0.62; 95% CI, 0.43-0.89) and fourth (HR, 0.67; 95% CI, 0.45-0.98) quartiles compared with quartile 1. Conclusions and relevance In this study, women with moderate and high prediagnosis dietary quality had significantly lower mortality rates from HGSOC compared with women with the lowest prediagnosis dietary quality. These findings suggest that even moderate adherence to dietary guidelines prior to diagnosis may be associated with improved survival among Black women with HGSOC, the most lethal form of ovarian cancer.
24-Hour Perioperative Antibiotic Prophylaxis for Cystectomy and Urinary Diversions—Less Is More
Authors: Peyton A. Skupin, Vanessa N. Peña, Bruce L. Jacobs
Journal: JAMA Network Open (2024)

Maria C. Thurnheer, MD; Astrid Schürmann, MD; Markus Huber, PhD; Jonas Marschall, MD; Patrick Y. Wuethrich, MD; Fiona C. Burkhard, MD
Genomic biomarkers predict response to combined ATR inhibition and radiotherapy
Authors: Benjamin R. Schrank, Lauren E. Colbert
Journal: Clinical Cancer Research (2024)

For decades, chemoradiosensitization with checkpoint kinase inhibitors has been proposed but largely unexplored. A recent study reports the novel ATR kinase inhibitor, RP-3500, synergizes with radiation to control Atm-/- tumors in vivo. RP-3500 did not radiosensitize wild-type or Brca-1 deficient tumors, highlighting the need for a genotype-tailored approach.
Chemotherapy Sparks Tertiary Lymphoid Structures in Metastatic Ovarian Cancer
Authors: Jesús Bravo Melgar, Damya Laoui
Journal: Clinical Cancer Research (2024)

Ovarian cancer remains resistant to immunotherapy in most patients, highlighting the need to make these tumors more immunogenic. A recent study unveils how chemotherapy is able to induce cancer cell stress in metastatic ovarian carcinomas, inducing the formation of tertiary lymphoid structures that create a "hotter" tumor microenvironment. See related article by Lanickova et al., p. 164.
Maternal Prenatal Cannabis Use and Child Autism Spectrum Disorder
Authors: Lyndsay A. Avalos, Mahlet Shenkute, Stacey E. Alexeeff, Nina Oberman, Lisa A. Croen, Meghan Davignon, Sara R. Adams, Deborah Ansley, Carley Castellanos, Kelly C. Young-Wolff
Journal: JAMA Network Open (2024)

Despite an increase in maternal prenatal cannabis use and associations with adverse neonatal outcomes, research on child neurodevelopmental outcomes is limited.
Disparities in Outcomes of Liver-Related Waiting List for Transplant—Is There an End in Sight?
Authors: Ashley Spann, Christine Lopez, Manhal Izzy
Journal: JAMA Network Open (2024)

Nicolas S. Rinella, MS; William Charlton, BS; Gautham Reddy, MD; Paige McLean Diaz, MD; Michael R. Charlton, MD
Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer’s disease
Authors: Yiran Zhang, Xiusheng Chen, Laiqiang Chen, Mingting Shao, Wenzhen Zhu, Tingting Xing, Tingting Guo, Qingqing Jia, Huiming Yang, Peng Yin, Xiao-Xin Yan, Jiandong Yu, Shihua Li, Xiao-Jiang Li, Su Yang
Journal: Molecular Neurodegeneration (2024)

The activation of endoplasmic reticulum (ER) stress is an early pathological hallmark of Alzheimer's disease (AD) brain, but how ER stress contributes to the onset and development of AD remains poorly characterized. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a non-canonical neurotrophic factor and an ER stress inducible protein. Previous studies reported that MANF is increased in the brains of both pre-symptomatic and symptomatic AD patients, but the consequence of the early rise in MANF protein is unknown.
A behaviourally informed chatbot increases vaccination rates in Argentina more than a one-way reminder
Authors: Dan Brown, Adelaida Barrera, Lucas Ibañez, Iván Budassi, Bridie Murphy, Pujen Shrestha, Sebastian Salomon-Ballada, Jorge Kriscovich, Fernando Torrente
Journal: Nature Human Behaviour (2024)

Maintaining COVID-19 vaccine demand was key to ending the global health emergency. To help do this, many governments used chatbots that provided personalized information guiding people on where, when and how to get vaccinated. We designed and tested a WhatsApp chatbot to understand whether two-way interactive messaging incorporating behaviourally informed functionalities could perform better than one-way message reminders. We ran a large-scale preregistered randomized controlled trial with 249,705 participants in Argentina, measuring vaccinations using Ministry of Health records. The behaviourally informed chatbot more than tripled COVID-19 vaccine uptake compared with the control group (a 1.6 percentage point increase (95% confidence interval, (1.36 pp, 1.77 pp)) and nearly doubled uptake compared with the one-way message reminder (a 1 percentage point increase (95% confidence interval, (0.83 pp, 1.17 pp)). Communications tools designed with behaviourally informed functionalities that simplify the vaccine user journey can increase vaccination more than traditional message reminders and may have applications to other health behaviours.
Inference-Based Cognitive Behavioral Therapy versus Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: A Multisite Randomized Controlled Non-Inferiority Trial
Authors: Nadja Wolf, Patricia van Oppen, Adriaan W Hoogendoorn, Odile A van den Heuvel, Harold J G M van Megen, Aniek Broekhuizen, Mirjam Kampman, Daniëlle C Cath, Koen R J Schruers, Saskia M van Es, Tamara Opdam, Anton J L M van Balkom, Henny A D Visser
Journal: Psychotherapy and Psychosomatics (2024)

Although cognitive behavioral therapy (CBT) effectively treats obsessive-compulsive disorder (OCD), many patients refuse CBT or drop out prematurely, partly because of anxiety regarding exposure and response prevention (ERP) exercises. Inference-based cognitive behavioral therapy (I-CBT) focuses on correcting distorted inferential thinking patterns, enhancing reality-based reasoning, and addressing obsessional doubt by targeting underlying dysfunctional reasoning, without incorporating an ERP component. We hypothesized that I-CBT would be non-inferior to CBT. Additionally, we hypothesized that I-CBT would be more tolerable than CBT.
Borosilicate bioactive glass synergizing low-dose antibiotic loaded implants to combat bacteria through ATP disruption and oxidative stress to sequentially achieve osseointegration
Authors: Mengke Fan, Youliang Ren, Yanbin Zhu, Hao Zhang, Shuaijie Li, Chunyu Liu, Hongzhi Lv, Lei Chu, Zhiyong Hou, Yingze Zhang, Haobo Pan, Xu Cui, Wei Chen
Journal: Bioactive Materials (2024)
Disparities in screening and risk stratification for hispanic adults with metabolic dysfunction-associated steatotic liver disease
Authors: Monica A. Tincopa, Luis Antonio Díaz, Daniel Q. Huang, Juan Pablo Arab, Marco Arrese, Adrian Gadano, Claudia P. Oliveira, Richele Bettencourt, Egbert Madamba, Susy Kim, Harris Siddiqi, Fernando Javier Barreyro, Sebastián Marciano, Jorge Martínez Morales, Cristiane Villela-Nogueira, Nathalie Leite, Claudia Alves Couto, Rafael Theodoro, Mísia Joyner de Sousa Dias Monteiro, Mario G. Pessoa, Mario Reis Alvares-da-Silva, Fatima Higuera de la Tijera, Constanza D. Sabate, Manuel Mendizabal, Lisa Richards, Claude B. Sirlin, Rohit Loomba
Journal: Hepatology (2024)

Cut-points for non-invasive tests (NITs) for risk stratification in metabolic dysfunction-associated steatotic liver disease (MASLD) were derived from predominantly non-Hispanic populations. It is unknown if these cut-points perform adequately in Hispanic individuals. We assessed the performance characteristics of current NIT cut-points among Hispanic patients and determined whether they could be further optimized.
Atezolizumab Plus Chemotherapy With or Without Bevacizumab in Advanced Biliary Tract Cancer: Clinical and Biomarker Data From the Randomized Phase II IMbrave151 Trial
Authors: Teresa Macarulla, Zhenggang Ren, Hong Jae Chon, Joon Oh Park, Jin Won Kim, Tiziana Pressiani, Daneng Li, Lyudmila Zhukova, Andrew X. Zhu, Ming-Huang Chen, Stephen P. Hack, Stephanie Wu, Bo Liu, Xiangnan Guan, Shan Lu, Yulei Wang, Anthony B. El-Khoueiry
Journal: Journal of Clinical Oncology (2024)

PURPOSE Biliary tract cancers (BTCs) harbor an immunosuppressed tumor microenvironment and respond poorly to PD-1/PD-L1 inhibitors. Bevacizumab (anti–vascular endothelial growth factor) plus chemotherapy can promote anticancer immunity, augmenting response to PD-L1 inhibition. PATIENTS AND METHODS This randomized, double-blind, proof-of-concept phase II study enrolled patients (n = 162) with previously untreated advanced BTC (IMbrave151; ClinicalTrials.gov identifier: NCT04677504 ). Patients were randomly assigned 1:1 to receive cycles of atezolizumab (1,200 mg) plus bevacizumab (15 mg/kg) or atezolizumab plus placebo once every 3 weeks until disease progression or unacceptable toxicity. All patients received cisplatin (25 mg/m 2 ) plus gemcitabine (1,000 mg/m 2 ; cisplatin plus gemcitabine [CisGem]) on days 1 and 8 once every 3 weeks for up to eight cycles. Stratification of patients was by disease status, geographic region, and primary tumor location. The primary end point was progression-free survival (PFS). No formal hypothesis testing was performed. Exploratory correlative biomarker analysis was undertaken using transcriptome analysis (n = 95) and mutation profiling (n = 102) on baseline tumor samples. RESULTS Between February and September 2021, 162 patients were enrolled. Median PFS was 8.3 months in the bevacizumab arm and 7.9 months in the placebo arm (stratified hazard ratio [HR], 0.67 [95% CI, 0.46 to 0.95]). Median overall survival (OS) was 14.9 and 14.6 months in the bevacizumab and placebo arms, respectively (stratified HR, 0.97 [95% CI, 0.64 to 1.47]). The incidence of grade 3 or 4 adverse events was 74% in both arms. High VEGFA gene expression was associated with improved PFS (HR, 0.44 [95% CI, 0.23 to 0.83]) in the bevacizumab arm versus placebo. CONCLUSION In unselected patients with advanced BTC, adding bevacizumab to atezolizumab plus CisGem modestly improves PFS but not OS. High VEGFA gene expression may represent a predictive biomarker of benefit from atezolizumab/bevacizumab, warranting further investigation.
R-loops’ m6A modification and its roles in cancers
Authors: Yue Qiu, Changfeng Man, Luyu Zhu, Shiqi Zhang, Xiaoyan Wang, Dandan Gong, Yu Fan
Journal: Molecular Cancer (2024)

R-loops are three-stranded nucleic acid structures composed of an RNA–DNA hybrid and a displaced DNA strand. They are widespread and play crucial roles in regulating gene expression, DNA replication, and DNA and histone modifications. However, their regulatory mechanisms remain unclear. As R-loop detection technology advances, changes in R-loop levels have been observed in cancer models, often associated with transcription-replication conflicts and genomic instability. N6-methyladenosine (m6A) is an RNA epigenetic modification that regulates gene expression by affecting RNA localization, splicing, translation, and degradation. Upon reviewing the literature, we found that R-loops with m6A modifications are implicated in tumor development and progression. This article summarizes the molecular mechanisms and detection methods of R-loops and m6A modifications in gene regulation, and reviews recent research on m6A-modified R-loops in oncology. Our goal is to provide new insights into the origins of genomic instability in cancer and potential strategies for targeted therapy.
A MnO2 nanosheets doping double crosslinked hydrogel for cartilage defect repair through alleviating inflammation and guiding chondrogenic differentiation
Authors: Feilong Zhao, Zhibo Jia, Liyang Zhang, Guodong Liu, Junfei Li, Jianming Zhao, Yajie Xie, Lu Chen, Hongyu Jiang, Wei He, Aiyuan Wang, Jiang Peng, Yudong Zheng
Journal: Biomaterials (2024)
Optimization of culture conditions to generate vascularized multi-lineage liver organoids with structural complexity and functionality
Authors: Kyun Yoo Chi, Gyeongmin Kim, Hyojin Kim, Hyemin Kim, Seongyea Jo, Jihun Lee, Youngseok Lee, Heeseok Yoon, Seunghyun Cho, Jeongjun Kim, Jin-Seok Lee, Gyu-Bum Yeon, Dae-Sung Kim, Han-Jin Park, Jong-Hoon Kim
Journal: Biomaterials (2024)
Prospective randomized trial comparing conventional and underwater endoscopic submucosal dissection for superficial colorectal neoplasms
Authors: Mitsuru Nagata, Masayuki Namiki, Tomoaki Fujikawa, Hiromi Munakata
Journal: Endoscopy (2024)

Abstract Background and study aims This study compared procedure-related outcomes of conventional and underwater endoscopic submucosal dissection (ESD) for superficial colorectal neoplasms (SCNs). Patients and methods In this single-center, randomized controlled trial, patients with SCNs meeting the indications of the Japanese guidelines for ESD were randomly assigned to undergo conventional ESD (CESD) or underwater ESD (UESD) performed by an expert. The primary endpoint was dissection speed, defined as the specimen area per ESD time. Results We analyzed the data of 69 and 70 CESD and UESD cases, respectively; however, no significant differences were found in median dissection speed (17.4 and 19.9 mm2/min, respectively; P=0.19). Multiple regression analysis revealed that the suitable positional relationship between the lesion and the direction of gravity (nongravity side for CESD and gravity side for UESD) was independently and positively associated with dissection speed (P&lt;0.001). En bloc resection was achieved without perforation in all cases. The incidence of post-ESD coagulation syndrome was not significantly different between the two groups (4.3% vs. 2.9%, respectively; P=0.68). Conclusions UESD did not expedite dissection speed in the overall patient population. CESD and UESD may be complementary in the colorectum depending on the positional relationship between the lesion and the direction of gravity.
High hospitalization rates and risk factors among frail patients with cirrhosis: A 10-year population-based cohort study
Authors: Bima J Hasjim, Mohsen Mohammadi, Salva N Balbale, Mitchell Paukner, Therese Banea, Haoyan Shi, Al'ona Furmanchuk, Lisa B VanWagner, Lihui Zhao, Andres Duarte-Rojo, Julianna Doll, Sanjay Mehrotra, Daniela P Ladner
Journal: Clinical Gastroenterology and Hepatology (2024)
Scaffolds functionalized with matrix metalloproteinase-responsive release of miRNA for synergistic magnetic hyperthermia and sensitizing chemotherapy of drug-tolerant breast cancer
Authors: Rui Sun, Man Wang, Tianjiao Zeng, Huajian Chen, Toru Yoshitomi, Masaki Takeguchi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Journal: Bioactive Materials (2024)
Continuous low-pressure saline perfusion for gastric endoscopic submucosal dissection
Authors: Yuji Ino, Hisashi Fukuda, Takashi Ueno, Hiroki Hayashi, Yoshie Nomoto, Haruo Takahashi, Hironori Yamamoto
Journal: Endoscopy (2024)

A method for conducting endoscopic submucosal dissection (ESD) by employing saline infusions in place of carbon dioxide has been reported [1]. This method effectively enhances the endoscopic visual field and maintains optimal intragastric pressure [2] [3]. Nevertheless, several limitations are noteworthy. First, blood admixture from bleeding events can significantly compromise visibility. Addressing this issue necessitates removing the incision device to suction the contaminated physiological saline solution. Second, potential bubble formation may obstruct the visual field by getting into the tip attachment. Consequently, operators are required to intermittently activate the foot pump of the water jet to disperse these bubbles.
When I use a word . . . Academic integrity—a brief history, a proposed definition, guidelines, and violations
Authors: Jeffrey K Aronson
Journal: BMJ (2024)

Although the concept of academic integrity has been long with us, and violations of it not uncommon, formal research into the topic began only in the 1990s, particularly by a pioneer in the field Donald McCabe of Rutgers University, whose main interest lay in the US collegiate system. In recent years concern about academic integrity, or rather the lack of it, has increased markedly, particularly in the area of research integrity. Having failed to find a satisfactory definition of academic integrity, I propose the following: uncorrupted moral virtue in relation to truth, uprightness, honesty, and sincerity in the pursuit of research, education, and scholarship. Several codes of conduct outline what is expected of academic researchers, of which the European Charter for Researchers is an example. A companion publication, the European Code of Conduct for Research Integrity, which deals in greater detail with the principles outlined in the European Charter for Researchers, and which itself refers to many other codes of practice, also outlines a range of possible violations of academic integrity, i.e. matters of academic dishonesty or misdemeanours. These include fabrication, falsification, and plagiarism, misuse of statistics, concealing the use of AI, withholding information, and selective or inaccurate citation. Other matters of concern include predatory journals, paper mills, and the large increase in the numbers of papers being retracted after publication.
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: role in aging and age-related diseases
Authors: Elena Ruggieri, Erika Di Domenico, Andrea Giacomo Locatelli, Flavio Isopo, Sarah Damanti, Rebecca De Lorenzo, Enrico Milan, Giovanna Musco, Patrizia Rovere-Querini, Simone Cenci, Emilie Vénéreau
Journal: Ageing Research Reviews (2024)
Circadian Clocks, Daily Stress, and Neurodegenerative Disease
Authors: Eugene Nyamugenda, Clark Rosensweig, Ravi Allada
Journal: Annual Review of Pathology Mechanisms of Disease (2024)

Disrupted circadian or 24-h rhythms are among the most common early findings in a wide range of neurodegenerative disorders. Once thought to be a mere consequence of the disease process, increasing evidence points toward a causal or contributory role of the circadian clock in neurodegenerative disease. Circadian clocks control many aspects of cellular biochemistry, including stress pathways implicated in neuronal survival and death. Given the dearth of disease-modifying therapies for these increasingly prevalent disorders, this understanding may lead to breakthroughs in the development of new treatments. In this review, we provide a background on circadian clocks and focus on some potential mechanisms that may be pivotal in neurodegeneration.
We need to rethink outcomes in Parkinson’s disease research
Authors: Johanne Juul Petersen, Sophie Juul, Caroline Barkholt Kamp, Annemette Løkkegaard, Janus Christian Jakobsen
Journal: BMJ (2024)

Over-reliance on symptom scales complicates the interpretation of research results for patients and clinicians. For future trials, it is crucial to prioritise primary outcomes that are relevant and understandable for patients
Harnessing 12-lead ECG and MRI data to personalise repolarisation profiles in cardiac digital twin models for enhanced virtual drug testing
Authors: Julia Camps, Zhinuo Jenny Wang, Ruben Doste, Lucas Arantes Berg, Maxx Holmes, Brodie Lawson, Jakub Tomek, Kevin Burrage, Alfonso Bueno-Orovio, Blanca Rodriguez
Journal: Medical Image Analysis (2024)
Prediction of helminthiases in travellers and migrants with eosinophilia: a cohort study.
Authors: Maëli van Waasdijk, Suzanne D van der Werff, Daniel Sjöholm, Katja Wyss, Hilmir Asgeirsson, Pontus Naucler, Anna Färnert, Ana Requena-Méndez
Journal: Clinical Microbiology and Infection (2024)
Corrigendum to “Cabozantinib Plus Nivolumab in Patients with Non–Clear Cell Renal Cell Carcinoma: Updated Results from a Phase II Trial” [Eur. Urol. 86(2) (2024) 90–94]
Authors: Kelly N Fitzgerald, Chung-Han Lee, Martin H Voss, Maria I Carlo, Andrea Knezevic, Laura Peralta, Yingbei Chen, Robert A Lefkowitz, Neil J Shah, Colette N Owens, Deaglan J McHugh, David H Aggen, Andrew L Laccetti, Ritesh R Kotecha, Darren R Feldman, Robert J Motzer
Journal: European Urology (2024)
The acid-sensing receptor GPR65 on tumor macrophages drives tumor growth in obesity
Authors: Sreya Bagchi, Robert Yuan, Han-Li Huang, Weiruo Zhang, David Kung-Chun Chiu, Hyungjoo Kim, Sophia L. Cha, Lorna Tolentino, Joshua Lowitz, Yilin Liu, Anna Moshnikova, Oleg Andreev, Sylvia Plevritis, Edgar G. Engleman
Journal: Science Immunology (2024)

Multiple cancers, including colorectal cancer (CRC), are more frequent and often more aggressive in individuals with obesity. Here, we showed that macrophages accumulated within tumors of patients with obesity and CRC and in obese CRC mice and that they promoted accelerated tumor growth. These changes were initiated by oleic acid accumulation and subsequent tumor cell–derived acid production and were driven by macrophage signaling through the acid-sensing receptor GPR65. We found a similar role for GPR65 in hepatocellular carcinoma (HCC) in obese mice. Tumors in patients with obesity and CRC or HCC also exhibited increased GPR65 expression, suggesting that the mechanism revealed here may contribute to tumor growth in a range of obesity-associated cancers and represent a potential therapeutic target.