THE ORAL USE OF COMBINED VITAMIN B_12 AND FOLIC ACID IN TROPICAL SPRUE
Authors: F DIEZ RIVAS, F HERNANDEZ MORALES, L M MEYER
Journal: Annals of Internal Medicine (1952)

Article1 April 1952THE ORAL USE OF COMBINED VITAMIN B12 AND FOLIC ACID IN TROPICAL SPRUERIVAS FEDERICO DIÉZ, M.D., MORALES FEDERICO HERNÁNDEZ, M.D., F.A.C.P., LEO M. MEYER, M.D.RIVAS FEDERICO DIÉZ, M.D.Search for more papers by this author, MORALES FEDERICO HERNÁNDEZ, M.D., F.A.C.P.Search for more papers by this author, LEO M. MEYER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-4-1076 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSoon after the announcement in July, 1945, of the synthesis of Lactobacillus casei factor by several investigators1 at the Lederle Laboratories and the Calco Division of the American Cyanamid Company, it was shown by Spies, Vilter and Koch2 that this substance possessed a definite hematopoietic effect in patients with macrocytic anemia when administered intravenously, intramuscularly or orally.In January, 1946, Spies, López, Menéndez, Minnich and Koch3reported that the macrocytic anemia of tropical sprue found in Cuba responded in a similar manner. Several other investigators4, 5, 6, 7, 8, 10also reported striking improvement of anemia when folic acid was...Bibliography1. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLipotropic activity of combinations of choline, vitamins B12 and B12b, folic acid, and citrovorum factorTropical Sprue and Vitamin B 12Folic acid and vitamin B12Some Nutritional Effects on the Metabolism of the Gastrointestinal MucosaVitamine und Vitaminkrankheiten 1 April 1952Volume 36, Issue 4Page: 1076-1085KeywordsAnemiaFolic acidHospital medicineLactobacillus ePublished: 1 December 2008 Issue Published: 1 April 1952 PDF downloadLoading ...