tbuckley/cabot-search huggingface dataset:
Proctology: A Treatise on the Malformations, Injuries and Diseases of the Rectum, Anus and Pelvic Colon.
Authors: Frank Clark Yeomans
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annual Review of Pharmacology and Toxicology
Authors: Robert George, Ronald Okun, Arthur K. Cho, Terrence F. Blaschke, Paul A. Insel, Susan G. Amara
Journal: The Annual Review of Pharmacology and Toxicology (2017)

The coordinated movement of organic anions (e.g., drugs, metabolites, signaling molecules, nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends, in large part, on organic anion transporters (OATs) [solute carrier 22 (...Read More
Lightning Strike and Autonomic Failure —Coincidence or Causally Related?
Authors: T S Weeramanthri, IB Puddey, L J Beilin
Journal: Journal of the Royal Society of Medicine (1991)

israeilii is a normal mouth commensal the significance of a positive finding on sputum culture and cytology may be difficult to assess. Bronchoscopy may be unhelpful3. Also since pulmonary actinomycosis may not be suspected because of its rarity, the appropriate transport media and culture techniques may not be utilized4. The computed tomogram may prove to be useful in the diagnosis of this disease in its early stages. It showed the presence of a pulmonary infiltrate with air bronchograms and also showed that the disease did not cross the oblique fissure or involve the pleural space or chest wall. These features appear to correspond to the initial lesion of pulmonary actinomycosis as described by Bates and Cruikshank'. The operative specimen showed extensive involvement of the lower lobe and thus differed from the minor involvement seen on CT. This difference can be accounted for by the time interval ofone month between CT and operation during which time the disease progressed. There are few CT descriptions ofpulmonary actinomycosis in the literature. Webb and Sagel5 in two patients with actinomycosis involving the chest wall drew attention to the pulmonary consolidation with involvement of adjacent pleura and chest wall. They also observed the presence of a pulmonary infiltrate with air bronchograms. James et al.6 described alveolar consolidation; an air bronchogram could be seen on their accompanying CT. Stanley and Lusk7 described an irregular tissue density containing small air bubbles. We would like to suggest that a pulmonary infiltrate with an air bronchogram is a CT feature of the initial lesion of pulmonary actinomycosis and the diagnosis should be considered when this pattern is seen.
Tubercle Bacillus Infection and Tuberculosis in Man and Animals. Processes of Infection and Resistance. A Biological and Experimental Study.
Authors: A. Calmette
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effectiveness of hip protectors
Authors: D. Torgerson
Journal: BMJ (2003)

# Results may not be generalisable to the community {#article-title-2} EDITOR—The hip protector trial reported by Meyer et al is methodologically a notable improvement on previous hip protector trials.1 However, some methodological shortcomings affect the study, and issues arise about its generalisability to people at high risk who are not resident in nursing homes. An important problem, not noted by the authors, is that the study groups have differential loss to follow up. In the intervention group 64% of the participants completed the 18 month follow up compared with only 57% of the controls (P=0.04). This difference can introduce selection bias and could give a false estimate of effectiveness. In addition, there seems to be some evidence that the control group may have been frailer than the intervention group as the death rate was somewhat greater and this may have explained the higher incidence of falls in the control group. These differences could explain some of the apparent effectiveness of the hip protectors. Interestingly, the compliance rate for the hip protectors was very low, at only 35%, not 68% as implied in the abstract. This low compliance rate is similar to that in our ongoing community study in which we simply post hip protectors to participants at high risk. Finally, although these data may support the use of hip protectors among nursing home residents, evidence for their effectiveness among older people at high risk who are living in the community is still required. We are undertaking a large individually randomised trial among 4200 women at increased risk of hip fracture living in the community, the results of which will be reported this summer.
Feasibility of a self-administered geriatric assessment tool for older patients with cancer
Authors: A. Hurria, S. Lichtman, S. Priyadarshi, J. Gardes, E. Zuckerman, P. Hamlin, W. Tew, E. Kelly, G. K. Abou-Alfa, M. Lachs
Journal: Journal of Clinical Oncology (2006)

18519 Background: As the population ages, there is an emerging need to develop a geriatric assessment (GA) tool for oncologists to characterize the ‘functional age‘ of older patients in order to tailor treatment, stratify outcomes by factors other than chronological age, and develop interventions to optimize cancer treatment. The GA tool must be easy to administer in order to minimize burden on clinic resources. The goal of this study was to determine the feasibility of administering a brief, comprehensive, self-administered GA tool to older patients before their meeting with the oncologist. Methods: The self-administered GA tool addresses the following domains: functional status, comorbidity, psychological state, nutritional status, and social support. The measures which comprise the tool are brief, reliable, validated, predictive of mortality and morbidity in older patients, and do not require a staff member to administer. Feasibility was assessed by the following parameters: 1) % able to complete the GA tool unassisted; 2) % requiring the assistance of staff members versus non-staff members; 3) overall patient satisfaction; 4) time to complete. Results: 168 (96%) of 175 patients completed the GA tool with a mean age of 76 (range 64–92) with AJCC stages [I (33%), II (17%), III (10%), IV (39%)] across a variety of tumor types. Of the study cohort, 67% were women, 57% were married, and 89% were retired. Median time to complete the GA tool was 13 minutes and mean time was 16 minutes (SD 11, range 3–60). Most completed the GA tool on their own (75%) or received assistance from a friend or family member (20%). Only 4% required assistance from a member of the healthcare team. Patient satisfaction with the GA tool was high: 88% satisfied with the length, 92% reported no difficult questions, and 97% reported no upsetting questions. Based on the assessment scores, the following interventions were offered: referral to a social worker (38%), nutritionist (43%), visiting nurse/home health aide (30%), internist (23%), rehabilitation (13%), ENT (13%), ophthalmology (7%), and psychiatry (5%). Conclusion: This brief, comprehensive, self-administered GA tool is feasible for use in the outpatient oncology setting. Prospective trials are needed to determine the effectiveness of the interventions offered. No significant financial relationships to disclose.
Kontrast und Schärfe im Röntgenbilde.
Authors: Willem Bronkhorst, Heinz Lossen
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changing Disciplines: Lectures on the History, Method and Motives of Social Pathology
Authors: John A. Ryle, Dorothy Porter
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumors of the Lower Respiratory Tract.
Authors: Averill A. Liebow
Journal: Annals of Internal Medicine (1954)

Carter & Eggleston have made an excellent job of rewriting Tumors of the Lower Respiratory Tract.This 17th fascicle of the 2nd series replaces Liebow's 1952 edition and is a worthy successor.The all-too-common bronchogenic carcino- mas are of course well covered but these fascicles are just as much consulted for information on the oddities and I could detect no omissions in this area.The rarer neoplasms are dealt with succinctly and sections on inflammatory pseudo- tumours and hamartomas ensure full coverage of primary and secondary tumours of the lower respiratory tract, including the pleura.The nomenclature used follows the WHO classification fairly closely and seems eminently sensible.
Long-Term Safety of Drug-Eluting and Bare-Metal Stents
Authors: Tullio Palmerini, Umberto Benedetto, Giuseppe Biondi-Zoccai, Diego Della Riva, Letizia Bacchi-Reggiani, Pieter C. Smits, Georgios J. Vlachojannis, Lisette Okkels Jensen, Evald H. Christiansen, Klára Berencsi, Marco Valgimigli, Carlotta Orlandi, Mario Petrou, Claudio Rapezzi, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2015)
Abstract 1157: Cardiac Consequences of Increased Amylin Secretion in Diabetics
Authors: Sanda Despa, Le Chen, Bethany Cummings, Peter J Havel, Kenneth B Margulies, Anne A Knowlton, Donald M Bers, Florin Despa
Journal: Circulation (2009)

Type-2 diabetes mellitus (T2DM) is linked to a cardiomyopathy, independent of coronary artery disease and hypertension. The molecular origins of this cardiomyopathy remain largely unknown. Our work...
Discovery of a tumor-specific biomarker for gastric cancer using proteomic analysis in tissue and serum
Authors: T. Mohri, Y. Mohri, D. G. Ward, W. Wei, Y. Qi, A. Martin, M. Kusunoki, P. J. Johnson
Journal: Journal of Clinical Oncology (2009)

e15582 Background: Gastric cancer is curable at an early stage. However, most cases are diagnosed at an advanced stage because of the lack of screening programs. Therefore, for early detection, there is a need for serum biomarkers to be identified. Methods: We explored surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to elucidate potential protein biomarkers of gastric cancer. Twenty-one resected gastric cancer samples were compared with matched adjacent normal mucosa samples. Serum from patients with gastric cancer (n=51) was compared with patients with benign gastric diseases (n=29). Samples were analyzed on Cu 2+ -loaded IMAC protein chips via surface-enhanced laser desorption /ionization time-of-flight mass spectrometry. Results: Comparisons of surface-enhanced laser desorption /ionization time-of-flight mass spectrometry spectra of 21 gastric cancer tissue extracts with paired adjacent normal mucosa showed a total of 56 differentially expressed protein peaks (p&lt;0.05; Wilcoxon test). Twenty-two were up-regulated in gastric cancer tissue, whereas 34 were down-regulated. The surface- enhanced laser desorption /ionization time-of-flight mass spectrometry spectra of serum contained 130 peaks, of which 67 were significantly associated with gastric cancer (p&lt;0.05; Wilcoxon test). We found five proteomic features (mass charge values of 2273, 3143, 3372, 3444, 3485) that were significantly up-regulated in both gastric cancer tissue and serum from gastric cancer patients. The peak intensities of tumor-specific proteomic features were used to develop a linear regression model for calculating a diagnostic index. The area under the receiver operating characteristic curve of the corresponding diagnostic index was 0.87. Conclusions: Serum biomarker panels associated with tumor tissue are capable of distinguishing gastric cancer patients from non-cancer ones. No significant financial relationships to disclose.
The Colloidal State in Its Medical and Physiological Aspects.
Authors: William M. Bayliss
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Operating theatre is better back up than venography
Authors: T. Davidson
Journal: BMJ (1995)

and a shortened lifespan of the catheter, but none was found.Recent studies have shown benefit from in- fusional chemotherapy,5 and its use is likely to increase.There could be a strong argument for rationalising use of the percutaneous technique of inserting central venous catheters: occasional operators are more likely to encounter difficuties, so specialist centres that insert over 200 a year are desirable and should incorporate a comprehensive education programme for both patients and staff.The background of the operator is not critical provided that he or she has been trained and is capable of treating complications, monitoring patients, and recovering them safely.The anaes- thetists at the Royal Marsden Hospitals provide this service and endeavour to refine the subtleties of the technique.
Generalized anxiety and generalized anxiety disorder: description and reconceptualization
Authors: David H Barlow, Edward B. Blanchard, James A. Vermilyea, Bonnie B. Vermilyea, Peter A. DiNardo
Journal: American Journal of Psychiatry (1986)

One hundred eight patients complaining of anxiety were diagnosed using the Anxiety Disorders Interview Schedule and classified into the various anxiety disorder categories as well as major depression. Although patients with a primary diagnosis of generalized anxiety disorder were more chronic than were panic disorder patients, most patients in each category met the DSM-III criteria for generalized anxiety disorder with the exception of simple phobic patients. On the basis of these data, it would seem that generalized anxiety disorder is a residual category within the anxiety disorders, since generalized anxiety disorder symptoms are almost always present. But if one distinguishes anticipatory anxiety, which is often part of panic or phobic disorders, from generalized anxiety, an independent anxiety disorder category emerges. This category is characterized by apprehensive expectation or chronic worry focused on multiple life situations.
Mentally ill people denied choice of drugs
Authors: J. O' Neale
Journal: BMJ (2000)

Sixty two per cent of people with mental health problems are denied a choice of drug treatment, said a new report published yesterday by the National Schizophrenia Fellowship. The report is based on a survey of 2600 people carried out by the Manic Depression Fellowship and Mind.

Although 73% of doctors discussed treatment, only 38% offered a choice, and only 54% …
Targeted Therapy for CNS Tumours with Monoclonal Antibodies (MAbs)
Authors: V. Papanastassiou, B. L. Pizer, R. Moseley, J. T. Kemshead, H. B. Coakham
Journal: Neuro-Oncology (1991)

The role of targeted radiation therapy in the treatment of CNS tumours is being investigated by our group in a number of studies. These involve leptomeningeal spread of medulloblastoma, CNS leukaemia, carcinomatous meningitis and malignant gliomas. MAbs specific to the various tumours have been radiolabelled with 131I and administered into the CSF compartment either via a lumbar puncture or intraventricularly via an Ommaya reservoir. Ommaya reservoirs have also been used for intratumoral administration of the radiolabel in cystic or partially resected malignant gliomas. Results from treating 14 cases of medulloblastoma, six of CNS leukaemia and 18 other types of neoplastic meningitis are reported below. Response rates of 42%, 83% and 33% respectively have been observed, with acceptable acute toxicity (70%) and reversible bone marrow toxicity (30%). New studies using this form of therapy in malignant gliomas are briefly discussed, in addition to new directions along which intrathecal therapy is being developed.
Practical points
Authors: David N Greig,
Journal: BMJ (2008)

I write with reference to Tonks’s article.1 On three occasions I have been asked to attend another passenger or a crew member on a longhaul flight.

An elderly man collapsed. He spoke no English. I did not realise how anaemic he was until we came in to land; curtains were drawn and it was dark outside. Once he was in daylight the diagnosis was obvious. The cabin staff had been reluctant to draw the curtains as it was still early morning. I suggest that where possible the curtains are drawn when you are making an assessment. The cabin staff wanted this passenger strapped upright in his seat for landing but I managed to persuade them to lie him on floor against a bulkhead. Even sitting him upright in his seat had caused him to faint. 

On two of the occasions when I saw a passenger, the captain of the aircraft discussed the option of diverting the flight, but I did not think it would help. I have always found the cabin staff well trained and helpful. One purser told me that on average, staff dealt with at least one medical problem in every 10 flights. 

By the way, the stethoscope in the kit is useless because the background noise from the aircraft’s engines drowns out any other sound.
Abstract 2904: Interleukin-18, the Metabolic Syndrome, and Subclinical Atherosclerosis: Results from the Dallas Heart Study
Authors: Andreas Zirlik, Shuaib M Abdullah, Norbert Gerdes, Lindsey MacFarlane, Uwe Schonbeck, Darren MacGuire, Amit Khera, Gloria L Vega, Scott Grundy, Peter Libby, James A de Lemos
Journal: Circulation (2006)

Background: Pro-inflammatory interleukin (IL)-18 promotes atherogenesis in animals and predicts cardiovascular risk in humans. We investigated whether IL-18 plasma levels associate with the metabol...
Abstract 15668: All-Cause and Cardiovascular Mortality in Women Undergoing Coronary Angiography: New Data with Extended Follow-up of the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE)
Authors: Sheryl F Kelsey, B Delia Johnson, Carl J Pepine, Vera Bittner, Diane Vido, Steven E Reis, Barry L Sharaf, C Noel Bairey Merz
Journal: Circulation (2011)

Background: The WISE was an observational study of 936 women undergoing coronary angiography for suspected ischemia. Long-term mortality for such women is not well documented. Methods: We conducted...