tbuckley/cabot-search huggingface dataset:
Changes Observed in the Heart Shadow in Toxic Goiter before and after Treatment
Authors: O. J. Menard, L. M. Hurxthal
Journal: Annals of Internal Medicine (1933)

Article1 June 1933Changes Observed in the Heart Shadow in Toxic Goiter before and after TreatmentO. J. MENARD, M.D., L. M. HURXTHAL, M.D., F.A.C.P.O. J. MENARD, M.D.Search for more papers by this author, L. M. HURXTHAL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-12-1634 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe object of this study was to determine what changes take place in the size and shape of the heart before and after subtotal thyroidectomy for hyperthyroidism. One hundred and fifteen cases were observed in which roentgenograms were taken before and at various phases during and after treatment.CLINICAL MATERIAL: ROENTGENOGRAPHIC METHODThe group of patients studied in this report do not represent a consecutive series. Forty-six cases were followed from a consecutive series of one hundred1; the remainder were isolated cases which we have collected during the past five years. Roentgenograms were taken when the patient was first seen...References1 HURXTHALMENARDBOGAN LMOJME: The size of the heart in goiter, Am. Jr. Med. Sci., 1932, clxxx, 772. Google Scholar2 PARKINSONCOOKSON JH: The size and shape of the heart in goiter, Quart. Jr. Med., 1931, xxiv, 499. CrossrefGoogle Scholar3 BAUERHELM JF: Über Roentgenbefunde bei Kropfherzen, Deutsch. Arch. f. klin. Med., 1913, cix, 73. Google Scholar4 KERRHENSEL WJGC: Observations on the cardiovascular system in thyroid disease, Arch. Int. Med., 1923, xxxi, 398. CrossrefGoogle Scholar5 RÖSLER H: Das Röntgenbild des Herzens beim Hyperthyreoidismus, Wien. Arch. f. im. Med., 1928, xv, 539-546. Google Scholar6 DALY IB: Reactions of the pulmonary and bronchial blood vessels, Physiol. Rev., 1933, xiii, 149. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read before the Symposium on Thyroid Heart Disease of the American Heart Association in New Orleans, May 1932.†From the Medical Department of the Lahey Clinic, Boston, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHerz und Kreislauf bei Störungen der SchilddrüsenfunktionKrankheiten der SchilddrüseDas Herz und der Kreislauf bei den Hyperthyreotikern 1 June 1933Volume 6, Issue 12Page: 1634-1643KeywordsCardiovascular therapyHeartHyperthyroidismLongitudinal studiesThyroidThyroidectomy Issue Published: 1 June 1933 PDF downloadLoading ...
Abstract 2086: Usefulness of Pneumatic Lower Extremity Compression During Dobutamine Stress Echocardiography
Authors: Hyung-Kwan Kim, Sung-A Chang, Jin-Shik Park, Yong-Jin Kim, Joo-Hee Zo, Hyung-Hee Oh, Young-Bae Park, Yun-Shik Choi, Dae-Won Sohn
Journal: Circulation (2007)

Background Afterload is expected to increase with pneumatic compression of the lower extremities. Therefore, left ventricular (LV) wall stress which is the most important factor determining myocardial oxygen demand will also increase, leading to an increase in sensitivity of dobutamine stress echocardiography (DSE) or shortened time to positive response.The purpose of this study was to evaluate the effect of pneumatic compression of lower extremities on the diagnostic accuracy of DSE. Methods In 40 patients who underwent DSE and were anticipating coronary angiography, DSE was repeated with the pneumatic compression (100mmHg) of lower extremities (DSEcomp) prior to coronary angiography. Sensitivity and specificity of DSE and DSEcomp were determined based on the coronary angiographic finding. Results All patients tolerated pneumatic compression of the lower extremities during the tests. LV end-systolic volume (p=0.042) and end-systolic wall stress (p=0.036) were significantly greater in the DSEcomp than DSE. In 3 patients with false negative results in DSE, DSEcomp showed positive responses, demonstrating a significant increase in sensitivity from 75% to 94% (p=0.045). Only 1 patient with true negative result in DSE was interpreted as showing positive response in DSEcomp, resulting in a decrease in specificity from 88% to 83% (p=NS). In 11 of 13 patients with true positive results both in DSE and DSEcomp, positive responses were seen at least 1 stage earlier in DSEcomp compared to DSE. Conclusions Pneumatic compression of lower extremities increases the sensitivity of DSE and shortens the time to positive response.
Not again!
Authors: D. M Berwick
Journal: BMJ (2001)

Again, a young patient with leukaemia is dying, not from his disease, but from an erroneous intrathecal injection of vincristine, intended for intravenous use.1 Again, the newspapers express outrage; they count up to 13 identical cases over the past 15 years. The hospital apologises, again, and two doctors are suspended, pending “investigation.” The NHS explains; steps will be taken, again.

And trust erodes, again, as a confused public, grieving with the patient and his family, wonder if they are safe. Spurred by the headlines, each asks, again, “Could I be next?” The answer, of course, is, “Yes.”

Less than a year ago the chief medical officer of England's NHS, in a landmark report on threats to patient safety in the NHS, courageously labelled the problem of medical errors as pervasive and consequential. He promised progress and even specified this very error—intrathecal injection of intravenous chemotherapeutic agents—as one targeted for “zero” occurrences: not just safer, but perfectly safe.2 So how could this happen—again?

The answer is surprisingly mundane. It is this: we are human, and …
The Disconnect Between the Guidelines, the Appropriate Use Criteria, and Reimbursement Coverage Decisions
Authors: Richard I. Fogel, Andrew E. Epstein, N.A. Mark Estes, Bruce D. Lindsay, John P. DiMarco, Mark S. Kremers, Suraj Kapa, Ralph G. Brindis, Andrea M. Russo
Journal: Journal of the American College of Cardiology (2013)
Psychiatric consultation in a Vietnamese refugee camp
Authors: R H Rahe, J G Looney, H W Ward, T M Tung, W T Liu
Journal: American Journal of Psychiatry (1978)

The authors provided psychiatric consultation to medical personnel in charge of a Vietnamese refugee camp in California. Although the emergency measures that supplied clothing, food, shelter, and medical care to nearly 60,000 refugees were immensely successful, consultation was requested to assist with selected mental health problems. The recommendations of the consulting team were related to the stage of camp development: early recommendations concerned easing adaptation to the camp setting; later efforts included creating a psychiatric crisis clinic and carrying out a mental health survey on a random sample of refugees. The results of this survey helped camp directors to understand how refugees responded to the camp experience.
EXPERIMENTAL HEART DISEASE
Authors: G. E. Hall
Journal: Annals of Internal Medicine (1939)

Article1 January 1939EXPERIMENTAL HEART DISEASEG. E. HALLG. E. HALLSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-7-907 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the great developments in clinical medicine of the past twenty years is the distinction between attacks of angina pectoris and attacks of coronary thrombosis. Even as late as 1923, Sir James Mackenzie did not make clinical diagnoses of coronary thrombosis.Dock in 1896 was perhaps the first to report an instance of coronary thrombosis diagnosed ante-mortem and proved at autopsy. Huchard in 1899, in a pathological study of 185 fatal cases of angina pectoris, paid close attention to the coronary artery and noted the frequency of coronary thrombosis. Krehl (1901) called attention to the possibility of recovery after... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Toronto, Ontario,*Read before the New York meeting of the American College of Physicians, April 5, 1938.From the Department of Medical Research, Banting Institute, University of Toronto. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und HerzinfarktNeurohormanal bedingte Herzkrankheiten (Pathogenese und Therapie)Cardiovascular Observations in Myasthenia gravis and Dystrophia myotonicaUntersuchungen über die Entstehung des MagengeschwürsObservations on the production of myocardial disease with acetylcholineHEART PAINNeurogenic heart lesions.1 1 January 1939Volume 12, Issue 7Page: 907-921KeywordsAnginaAutopsyCardiovascular therapyCoronary arteriesThrombosis ePublished: 1 December 2008 Issue Published: 1 January 1939 Copyright & PermissionsCopyright, 1939, by The American College of PhysiciansPDF downloadLoading ...
Abstract 3240: Geometric Differences of Mitral Apparatus Between Ischemic and Dilated Cardiomyopathy With Significant Mitral Regurgitation: Three-Dimensional Analysis With Multislice Computed Tomography
Authors: Kitae Kim, Shuichiro Kaji, Yoshimori An, Takeshi Kitai, Atsushi Kobori, Natsuhiko Ehara, Koichi Tamita, Makoto Kinoshita, Atsushi Yamamuro, Tomoko Tani, Yutaka Furukawa
Journal: Circulation (2009)

Background: The three-dimensional (3D) geometry of the mitral apparatus accompanied by regional or global LV dilatation has not been well investigated. We assessed 3D geometric differences of the m...
Suspected transmission of tuberculosis in a maternity ward from a smear-positive nurse: preliminary results of clinical evaluations and testing of neonates potentially exposed, Rome, Italy, 1 January to 28 July 2011
Authors: P Borgia, A Cambieri, F Chini, L Coltella, G Delogu, E Di Rosa, G Fadda, P Giorgi Rossi, E Girardi, D Goletti, G Guasticchi, A Morrone, P Pezzotti, C Romagnoli, M T Sacerdote, C Russo, A Villani, L Zarelli
Journal: Eurosurveillance (2011)

We report preventive measures adopted after tuberculosis (TB) transmission from a nurse to a newborn assessed in late July 2011. All exposed neonates born between January and July 2011 were clinically evaluated and tested by QuantiFERON TB gold in-tube; newborns testing positive were referred for prophylaxis. Of 1,340 newborns, 118 (9%) tested positive and no other active cases of TB were found. Active surveillance for TB will be continued over the next three years for all those exposed.
Continent Ileocaecal Urinary Reservoir
Authors: M Handley Ashken
Journal: Journal of the Royal Society of Medicine (1978)

In 14 cases, a continent ureteroileocaecal urinary reservoir has been constructed. If a long-term ease of self catheterization can be maintained, some patients requiring an urinary diversion might prefer an appliance-free urinary reservoir to a freely draining conduit and urinary appliance. The indications and place for the continent urinary reservoir still need to be studied, modified and proven during the coming years.
Integrated care intervention prevents hospitalisations for exacerbations and reduces the disease costs in COPD patients
Authors: Sara Balestracci, Anna Porcu, Erika Fiumalbi, Mariella Polselli, Fimmg Progetto Mito, PierCarlo Rossi, Andrea Macuzzi, Maurizio Moretti
Journal: European Respiratory Journal (2011)

Introduction:  Efficacy of interventions aimed at preventing hospitalisations due to exacerbations in clinically stable COPD patients is controversial.   Objectives:  To evaluate usefulness of integrated care intervention (ICI) on hospital admission for exacerbations and disease costs in COPD patients.   Methods:  This prospective study was carried out in 208 COPD patients recruited by general practitioners between January 2009 and December 2009 in Massa-Carrara sanitary district.  The interventions included individually tailored care plan following GOLD guidelines shared among the chest physician, nurse team and general practitioner, educational program on self-management of the disease, treatment supervision during scheduled visits, home visits by specialised nurses.   Results:  105 patients completed 12 months of follow-up, stratified in stage 1 (n.11), stage 2 (n.47), stage 3 (n.34), stage 4 (n.13) using the GOLD classification.  Twelve months of ICI decreased the mean number of hospitalisations (0.54±1.1 versus 0.82±1.1 p   Conclusions:  The study demonstrates that a standardised ICI based on share-care intervention between primary care team and hospital team effectively prevents hospitalisations for exacerbations and decreases the total disease cost in COPD patients.
The Bacteriuria In Renal Transplantation (BIRT) study: A prospective, randomized, parallel-group, multicenter, open-label, superiority trial comparing antibiotics versus no treatment in the prevention of symptomatic urinary tract infection in kidney transplant recipients with asymptomatic bacteriuria (protocol).
Authors: Julien Coussement, Marc Hazzan, Laurent Weekers, Sandrine Roisin, Emine Nilufer Broeders, Jean-Louis Bosmans, Herman Goossens, Frédérique Jacobs, Mireille N Kianda, Philippe Madhoun, Patrick Peeters, Steven Van Laecke, Judith Racapé, Lidia Ghisdal, Magali Giral, Karl Martin Wissing, Daniel Abramowicz
Journal: The Lancet (2014)
Myogenic regulatory factors expression in skeletal muscle changes during ventricular dysfunction and heart failure
Authors: P. F. Martinez, Katashi Okoshi, Leonardo Antonio Mamede Zornoff, R. F. Carvalho, S. A. Oliveira, D. H. S. Campos, A. R. R. Lima, Célia Regina Nogueira, M. Dal Pai-Silva, Marina Politi Okoshi
Journal: Circulation (2008)
Vascular Responses to Long- and Short-Term Exposure to Fine Particulate Matter
Authors: Ranjini M. Krishnan, Sara D. Adar, Adam A. Szpiro, Neal W. Jorgensen, Victor C. Van Hee, R. Graham Barr, Marie S. O'Neill, David M. Herrington, Joseph F. Polak, Joel D. Kaufman
Journal: Journal of the American College of Cardiology (2012)
NITROGEN BALANCE STUDIES IN CHRONIC PEPTIC ULCER DISEASE
Authors: T S SAPPINGTON, H L BOCKUS
Journal: Annals of Internal Medicine (1949)

Article1 August 1949NITROGEN BALANCE STUDIES IN CHRONIC PEPTIC ULCER DISEASETHOMAS S. SAPPINGTON, M.D., HENRY L. BOCKUS, M.D., F.A.C.P.THOMAS S. SAPPINGTON, M.D.Search for more papers by this author, HENRY L. BOCKUS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-2-271 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years considerable interest has been shown in the nutritional aspects of peptic ulcer therapy. Some authors have not only reminded their readers that the ulcer patient has the same diverse food requirements as other persons, but have claimed special therapeutic value for "hyperalimentation" programs in the treatment of patients with uncomplicated peptic ulcer. Co Tui has emphasized the beneficial effect of a diet containing very large amounts of partially hydrolyzed protein.1There are ample data to demonstrate the importance of a high protein intake in the treatment of a host of chronic illnesses and, in the convalescent period,...Bibliography1. TUIWRIGHTMULHOLLANDGALVINBARCHAMGERST CAMJHTIGR: The hyperalimentation treatment of peptic ulcer with amino acids (protein hydrolysate) and dextri-maltose, Gastroenterology, 1945, v, 5. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication March 25, 1948.From the Gastrointestinal Service of the Graduate Hospital of the University of Pennsylvania.Aided by a grant from the Julia Keim Memorial Fund.†American College of Physicians Research Fellow in Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRecent Advances in the Medical Treatment of Peptic UlcerHyperalimentation in the Management of Pyloric Obstruction with Comments on Certain Theoretical Relationships between Protein Deficiency and Peptic UlcerDie Krankheiten des MagensThe Relation of Protein Metabolism to Disease 1 August 1949Volume 31, Issue 2Page: 271-281KeywordsDiagnostic radiologyDietEatingFoodGraduate medical educationNutritionPatientsPeptic ulcersProteins ePublished: 1 December 2008 Issue Published: 1 August 1949 PDF downloadLoading ...
Abstract 319: Small Molecule Gβγ Inhibition Attenuates Cardiac Fibroblast Inflammatory and Pro-Fibrotic Signaling
Authors: Joshua G Travers, Fadia A Kamal, Michael S Burhans, Burns C Blaxall
Journal: Circulation Research (2014)

Heart failure (HF) is a devastating disease characterized by chamber remodeling, interstitial fibrosis and reduced ventricular compliance. Prolonged sympathetic overstimulation promotes excess signaling through G-protein Gβγ subunits and ultimately results in pathologic GRK2-mediated β-adrenergic receptor (β-AR) downregulation. We have recently demonstrated the therapeutic potential of the small molecule Gβγ-GRK2 inhibitor Gallein in limiting HF progression. Pathologic activation of the cardiac fibroblast (CF) induces the transition to a myofibroblast phenotype, which plays a fundamental role in myocardial fibrosis and remodeling. We hypothesized that Gβγ-GRK2 inhibition plays an important functional role in the CF to attenuate pathologic CF activation, inflammation and interstitial fibrosis. To explore the effect of Gβγ-GRK2 inhibition on inflammation and pro-fibrotic signaling, mice were subjected to 7 days of transverse aortic constriction, a pressure-overload model of HF. In addition to the attenuation in overall cardiac hypertrophy, animals treated with Gallein displayed reduced expression of pro-inflammatory cytokines, including macrophage inflammatory protein 1 alpha (MIP-1α) and MIP-1β, along with Interleukin-6, as assessed by qPCR. Gallein-treated animals also exhibited diminished pro-fibrotic signaling, as evidenced by a reduction in the expression of TGFβ, a major driver of myocardial fibrosis, and decreased expression of collagen. To recapitulate these findings in vitro, primary adult mouse ventricular fibroblasts were pathologically stimulated using Isoproterenol (ISO, β-AR agonist) or Angiotensin II and treated +/- Gallein for 24 hours. CFs treated with Gallein displayed an analogous reduction in the expression of these pro-inflammatory cytokines and collagen. In summary, these data suggest a potential therapeutic role for small molecule Gβγ-GRK2 inhibition in limiting pathologic myofibroblast activation, inflammation and interstitial fibrosis. We believe this fibroblast-targeted approach will lead to the refinement of existing targets and compounds, and possibly the generation of novel therapeutics for the treatment of HF.
The normalcy of self-proclaimed "normal volunteers"
Authors: U Halbreich, Y Bakhai, K B Bacon, S Goldstein, G M Asnis, J Endicott, J Lesser
Journal: American Journal of Psychiatry (1989)

Volunteers who claimed they were "healthy and normal" and did not reveal any physical or mental abnormality or medication use during brief structured interviews underwent detailed structured interviews with the Schedule for Affective Disorders and Schizophrenia. Diagnoses were based on the Research Diagnostic Criteria (RDC), and family history was determined with the Family History RDC. Of the 121 volunteers, 16.5% met criteria for diagnoses of current mental disorders. Of the 104 without current DSM-III axis I diagnoses, 35.6% had past histories and 39.4% had family histories of mental illness. These results emphasize the need for thorough assessment of "normal volunteers."
Danger of Warming Transfusion Fluids
Authors: J. Wallace
Journal: BMJ (1948)

SIR,-I was interested in Dr. K. M. Tomlinson's letter (Feb.7, p. 276) concerning " benadryl" and hay fever.Last August I, too, treated my hay fever with benadryl and had complete relief from the symptoms; in September I developed a form of eczema of the beard area which persisted for some weeks and was eventually proved to be due to sensitivity to a brushless shaving cream which I had been using for about twelve months.Having never had any skin condition like this before, I assume that benadryl may have been in some way responsible.Is it possible that the absence of histamine action in a tissue renders it more liable to become sensitized by a foreign protein ?It would be interesting to hear of any cases of asthma developing after the use of benadryl.-Iam, etc., Bristol.A. R. WEAR.Iridocycfitis Treated with Benadryl SIR,-I was interested to see Dr. Barbara Shaw's letter (Feb.7, p. 277) under the above heading.I have been subject to attacks of iridocyclitis since 1944.My last attack started on Dec. I1, 1947, and lasted approximately seven weeks. 1 performed all the usual investigations, but was unable to find any cause.I was, I found, also liable to sensitivity reactions from various drops which I instilled-namely, hyoscine, hyoscyamine, and atropine-and on this account I used homatropine for a short time.This, however, was not strong enough and I developed approximately 12 posterior synechiae.I was then obliged to revert to atropine and at the same time I began to take " bena- dryl" 50 mg.t.d.s.This entirely alleviated the sensitivity re- action and I continued to take it for three weeks.It was then discontinued and atropine was exhibited for a further fortnight.In this case, therefore, I -do not think that benadryl had the slightest effect on the course of the iridocyclitis.-Iam, etc.,
Abstract 2823: Right Ventricular Septal Versus Apical Pacing: Long Term Impact On Left Ventricular Synchrony And Function
Authors: Arnold Ng, Christine Allman, Jane Vidaic, Hui Tei, Andrew P Hopkins, Dominic Y Leung
Journal: Circulation (2008)

Background: Right ventricular (RV) septal pacing has been advocated as an alternative to RV apical pacing to avoid long term detrimental effects. There is conflicting evidence on the benefits of RV septal pacing. No studies have previously compared left ventricular (LV) strain and dyssynchrony between different pacing sites and utilized echocardiography to determine pacing sites. Methods: 55 patients (22 normal controls, 17 RV septal and 17 RV apical pacing) were recruited. LV circumferential and radial strain were determined in the midventricular short axis views. Circumferential and radial strain synchrony, and longitudinal systolic (SDTs) and diastolic (SDTe) dyssynchrony indices were determined. Echocardiographic determination of pacing sites were compared with ECG and chest x-ray (CXR). Results: The median pacing durations were 436 days for RV septal and 2398 days for RV apical pacing. Mean QRS duration were significantly shorter for septal than apical pacing and normal controls (139.8 ± 22.6 vs. 162.4 ± 22.9 vs. 85.9 ± 15.2 msec respectively, p &lt; 0.001). LV mass index, end-systolic volume index and ejection fraction were more impaired in RV septal than apical pacing (108.2 ± 27.2 vs. 91.5 ± 15.4 g/m 2 , 21.3 ± 3.7 vs. 19.4 ± 9.3mL/m 2 , 47.6 ± 8.5 vs. 54.2 ± 7.8% respectively, all p &lt; 0.05). RV septal pacing was associated with more impaired circumferential strain (p &lt; 0.001) and worse circumferential strain dyssynchrony (p = 0.02) than apical pacing and normal controls. There were no significant differences in radial strain, radial strain dyssynchrony or SDTs. RV septal pacing consisted of a heterogeneous group of different pacing sites on echocardiography, and there was only modest agreement between echocardiographic, ECG and CXR determinations of pacing sites. Conclusions: RV septal pacing was associated with poorer long term LV function and greater dyssynchrony than RV apical pacing and normal controls.