The Relation of Experimental Rheumatoid Inflammation to Allergy†
Authors: B. J. Clawson
Journal: Annals of Internal Medicine (1930)

Article1 November 1930The Relation of Experimental Rheumatoid Inflammation to Allergy†B. J. CLAWSON, M.D.B. J. CLAWSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-5-433 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe microscopic lesions found in acute rheumatic fever have quite generally come to be considered characteristic (not specific) anatomic features of the disease both by those who believe the streptococcus to be the exciting agent and by those who believe that the disease is produced by an unknown virus. The lesions show mononuclear and multinucleated cells with vesicular or hyperchromatic nuclei (the so-called Aschoff cells), lymphocytes, plasma cells, eosinophiles, and a varying number of polymorphonuclear leucocytes.Such inflammation, either in nodules or in irregular diffuse arrangement, has been described as occurring in the subcutaneous tissues, joints, tendons, galea aponeurotica, diaphragm...Bibliography1 ASCHOFF L: Zur Myocarditisfrage, Verhandl. d. deutsch. path. Gesellsch. 8:46, 1904. Google Scholar2 GEIPEL P: Untersuchungen über rheumatische Myokarditis, Deutsches Arch. f. klin. Med. 85:75, 1905-1906. Google Scholar3 HIRSCHSPRUNG : Jahrb. f. Kinderh., 1881; Cited by Frank, P.: Berl. klin. Wchnschr. 49:1358, 1912. Google Scholar4 BARLOWWARNER TF: On Subcutaneous Nodules, Tr. Seventh Internat. Med. Cong. London 4:116, 1881. Google Scholar5 FUTCHER TB: A Study of Subcutaneous Fibroid Nodules, Bull. Johns Hopkins Hosp. 6:133, 1895. Google Scholar6 FRANK P: Ueber den Rheumatismus nodosus mit besonderer Berüchsichtigung des pathlogischanatomischen Befundes, Berl. klin. Wchnschr. 49:1358, 1912. Google Scholar7 SWIFT HF: Pathogenesis of Rheumatism, J. Exper. Med. 39:497, 1924. CrossrefMedlineGoogle Scholar8 COOMBS C: Myocardial Lesions of the Rheumatic Infection, Brit. M. J. 2:1513, 1907. Google Scholar9 COOMBSMILLERKETTLE CREH: The Histology of Experimental Rheumatism, Lancet 2, 1209. 1912. CrossrefGoogle Scholar10 JACKSON L: Experimental "Rheumatic Myocarditis", J. Infect. Dis. 11:243, 1912. CrossrefGoogle Scholar11 SMALL JC: Rheumatic Fever, Am. J. M. Sc. 175:650, 1928. CrossrefGoogle Scholar12 CLAWSON BJ: Experimental Rheumatoid Myocarditis, Arch. Path. 2:799, 1926. Google Scholar13 CLAWSON BJ: Experimental Subcutaneous Rheumatic Nodules, Am. J. Path. 4:565, 1928. MedlineGoogle Scholar14 DERICKSWIFT CLHF: Reactions of Rabbits to Non-hemolytic Streptococci. J. Exper. Med. 49:615. 1929. CrossrefMedlineGoogle Scholar15 BIRKHAUG KE: Rheumatic Fever; Skin Hypersensitiveness of Patients with Rheumatic Fever and Chronic Arthritides to Filtrates, Autolysates, and Bacterial Suspensions of Streptococci, J. Infect. Dis. 44:363, 1929. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minn.From the Department of Pathology, University of Minnesota.*Read before the American College of Physicians, February 12, 1930. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySpezieller TeilAllergische KrankheitenAllergische KrankheitenDiscussion on the Skin Manifestations in RheumatismGelenkrheumatismus und AllergieAllergic diseasesQuantenmechanik der Ein- und Zwei-Elektronenprobleme 1 November 1930Volume 4, Issue 5Page: 433-439KeywordsAnatomical pathologyCellsInflammationLesionsLymphocytesPlasma cellsRheumatic feverStreptococcusTendons ePublished: 1 December 2008 Issue Published: 1 November 1930 PDF downloadLoading ...