tbuckley/cabot-search huggingface dataset:
Effects of a general practitioner-led brief narrative exposure intervention on symptoms of post-traumatic stress disorder after intensive care (PICTURE): multicentre, observer blind, randomised controlled trial
Authors: Jochen Gensichen, Konrad F R Schmidt, Linda Sanftenberg, Robert P Kosilek, Chris M Friemel, Antina Beutel, Johanna Dohmann, Christoph Heintze, Hallie C Prescott, Ulf-Dietrich Reips, Maggie Schauer, Daniela Lindemann, Christian Brettschneider, Tobias Dreischulte, Bernhard Zwißler, Thomas Elbert
Journal: BMJ (2025)

To determine the effect of a novel brief general practitioner (GP)-led narrative exposure intervention on post-traumatic stress disorder (PTSD) symptoms after intensive care. Multicentre, observer blind, randomised controlled trial (PICTURE). Primary care in 319 general practices across Germany. 319 adults (18-85 years) who have survived critical illness with symptoms of PTSD, discharged from intensive care and randomised to receive the intervention (n=160) or improved usual care (n=159) from a general practitioner. Intervention group participants had three narrative exposure consultations with a general practitioner and eight scheduled contacts with a nurse. Control group participants received improved treatment as usual based on the German PTSD guideline. The primary clinical outcome was self-reported PTSD symptoms using the Post-Traumatic Diagnostic Scale for DSM-5 (PDS-5, range 0-80, higher scores indicating more severe symptoms) at six months. The minimal clinically important difference was six points. Secondary outcomes included changes in depression, anxiety, patient activation, health related quality of life and disability at six and 12 months. Between 21 October 2018 and 18 January 2023, 1283 patients discharged from an intensive care unit were screened for PTSD symptoms. 319 study participants were randomly assigned either to the control group (n=159) or the intervention group (n=160). The mean patient age was 57.7 years (standard deviation (SD) 12.7), and 61% of participants were male. The mean baseline PDS-5 score was 30.6 (SD 13.3) in both groups. 271 (85%) study participants completed follow-up assessment after six months and 247 (77%) after 12 months. The intervention effect showed a mean between-group difference in the PDS-5 score of 4.7 points ((95% confidence interval 1.6 to 7.8); P=0.003, Cohen's d=0.37)) at six months and 5.4 points ((1.8 to 9.0); P=0.003, Cohen's d=0.41)) at 12 months. Among secondary outcomes, patients in the intervention group had greater improvements in depression, health related quality of life, and disability. In adults with symptoms of PTSD after critical illness, a brief narrative exposure intervention was feasible and showed a reduction of symptoms, which was less than the predefined minimal clinically important difference. The effect was found to be sustained at 12 months' follow-up. These findings support the further evaluation of this intervention in primary care. ClinicalTrials.gov, NCT03315390; DRKS-ID DRKS00012589.
Aetiological phenotypes of atrial and ventricular secondary tricuspid regurgitation and their prognostic implications: insights from the <scp>CARE</scp>‐<scp>TR</scp> registry
Authors: Laura Lupi, Elena Antonioli, Angelica Praderio, Alessandro Villaschi, Elisa Soranzo, Nicola Saccani, Kamil Stankowski, Daniele Cocianni, Beniamino Pagliaro, Valeria Magni, Marco Loffi, Daniela Tomasoni, Matteo Pagnesi, Antonio Mangieri, Davide Stolfo, Gianfranco Sinagra, Marianna Adamo, Marco Metra
Journal: European Journal of Heart Failure (2025)

Abstract Aims To report prevalence and clinical outcomes of different aetiological phenotypes of atrial and ventricular secondary tricuspid regurgitation (ASTR/VSTR). Methods and results The Consecutive pAtients with seveRE Tricuspid Regurgitation evaluated in Heart Failure (HF) and Valve Clinics (CARE‐TR) registry collected data from patients with at least severe tricuspid regurgitation (TR) enrolled at three Italian centres. The present analysis includes 648 patients with secondary TR, 22.1% with ASTR and 77.9% with VSTR. Patients with ASTR were further stratified in those with atrial fibrillation (AF, 25.2%), HF with preserved ejection fraction (HFpEF, 37.8%), and both (37.0%). Patients with VSTR were subdivided into those with severe left‐sided valvular heart disease (LS‐VHD, 28.5%), HF with reduced or mildly reduced ejection fraction (HFrEF/HFmrEF, 29.1%), HFpEF (35.5%), pre‐capillary pulmonary hypertension (PH, 4.0%) and isolated right ventricular dysfunction (RVD, 2.9%). After a median follow‐up of 498 days, 118 (18.2%) patients died and 153 (23.6%) were hospitalized for HF. Two‐year survival free from the composite outcome of death or HF hospitalization was higher in patients with ASTR compared with those with VSTR (73.5% vs. 54.4%; p &lt; 0.001). After adjustment for variables related with HF severity, VSTR remained independently associated with an increased risk of events (adjusted hazard ratio 2.00; 95% confidence interval 1.33–3.02; p = 0.001). Among ASTR patients, combined AF and HFpEF was associated with a poorer outcome compared with AF or HFpEF alone (60.2% vs. 80.5% vs. 83.6%; p = 0.022). Among patients with VSTR, overall survival free from the composite outcome was 85%, 65%, 54%, 39% and 38% for RVD, HFpEF, HFrEF/HFmrEF, severe LS‐VHD, and pre‐capillary PH, respectively ( p &lt; 0.001). Conclusions In a real‐world population with at least severe secondary TR, 22% had ASTR and showed better outcomes as compared to VSTR. Among patients with ASTR, combination of AF and HFpEF was common and associated with the worst prognosis. Among patients with VSTR, those with pre‐capillary PH had the poorest outcomes, followed by those with LS‐VHD.
Donor heart allocation systems in Europe. A scientific statement of the Heart Failure Association of the <scp>ESC</scp>
Authors: Hoong Sern Lim, Kevin Damman, Guillaume Baudry, Maja Cikes, Stamatis Adamopoulos, Tuvia Ben‐Gal, Nicolas Girerd, Andreas Zuckermann, Marco Masetti, Sanem Nalbantgil, Laurens Tops, Piotr Ponikowski, Maria Crespo‐Leiro, Frank Ruschitzka, Marco Metra, Finn Gustafsson
Journal: European Journal of Heart Failure (2025)
Harnessing nutrient scarcity for enhanced CAR-T-cell potency and safety in solid tumors
Authors: Enzo Manchon, Nell Hirt, Benjamin Versier, Aravindhan Soundiramourty, Ludmila Juricek, Celeste Lebbe, Maxime Battistella, Yves Christen, Jacques Mallet, Dominique Charron, Nabila Jabrane-Ferrat, Che Serguera, Reem Al-Daccak
Journal: Cellular and Molecular Immunology (2025)

Abstract Despite significant advancements, the effectiveness of chimeric antigen receptor (CAR)-T-cell-based therapies in solid tumors remains limited. Key challenges include on-target effects, off-tumor toxicity and reduced CAR-T-cell function within the tumor microenvironment, which is often characterized by metabolic stress triggered by factors such as amino acid scarcity. Activating transcription factor-4 (ATF4) and its upstream regulator GCN2 play crucial roles in the metabolic reprogramming and functionality of CD4 + and CD8 + T cells. ATF4 can be activated by various cellular stress signals, including amino acid deprivation. While ATF4 activation may be associated with T-cell dysfunction, its role in stress adaptation presents an opportunity for therapeutic intervention—particularly in the tumor microenvironment, where T-cell exhaustion is a major challenge. In this study, we developed a strategy to harness the GCN2‒ATF4 axis in CAR-T cells. We employed an amino acid-dependent inducible promoter, which triggers ATF4-dependent gene expression to regulate CAR expression in T cells under conditions of amino acid scarcity within the tumor microenvironment. In vitro and murine xenograft models demonstrate the potential of this system to effectively restrict CAR expression to the tumor site. This targeted strategy not only enhances safety by minimizing off-tumor activity but also CAR-T-cell fitness by reducing exhaustion. By validating this pathophysiologically regulatable CAR expression system for solid tumors, our findings address key limitations of current CAR-T-cell therapies and pave the way for innovative strategies targeting solid malignancies.
FXR protects against neonatal sepsis by enhancing the immunosuppressive function of MDSCs
Authors: Juan He, Yuxin Zhang, Yuchao Jing, Rui Dong, Tongyang Li, Xiaoqing Zheng, Pan Zhou, Kun Shi, Wei Zhong, Qiang Liu, Jie Zhou
Journal: Cellular and Molecular Immunology (2025)
Living network meta-analysis to compare nemolizumab against other available targeted systemic treatments for atopic dermatitis
Authors: Aaron M Drucker, Chantel Walwyn, Cherry Chu, Zenas Z N Yiu, Bram Rochwerg, Sonya Di Giorgio, Bernd W M Arents, Tanya Mohan, Tim Burton, Phyllis I Spuls, Jochen Schmitt, David Prieto-Merino, Carsten Flohr
Journal: British Journal of Dermatology (2025)

Nemolizumab is a new biologic approved to treat atopic dermatitis. In this perspective piece, we use results from our living systematic review and network meta-analysis to provide perspective on the relative efficacy of nemolizumab compared to other approved targeted systemic treatments.
Association between perfluorooctanoic acid-related poor embryo quality and metabolite alterations in human follicular fluid during IVF：A Cohort Study
Authors: Junting Xu, Qiaoling Wang, Xianting Jiao, Pengcheng Kong, Siyu Chen, Wanli Yang, Wenqiang Liu, Kunming Li, Xiaoming Teng, Yi Guo
Journal: Environmental Health Perspectives (2025)

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been shown to disrupt normal follicular development and ovulation. However, it is unknown which specific PFAS in follicular fluid negatively impact oocyte development and embryo quality or whether any of the metabolites present in the follicular fluid contribute to these adverse effects. We conducted a cross-sectional and cohort study to identify specific PFAS with significant adverse effects on embryo quality and their associated modes of action. We enrolled 378 women undergoing assisted reproductive technology (ART) and collected follicular fluid samples during oocyte retrieval. We performed PFAS detection and untargeted metabolomics on the follicular fluid. The association of individual PFAS with high-quality embryo rates and clinical pregnancy outcomes were assessed using beta regression and logistic regression, respectively, and potential joint effect of mixtures of PFAS using Bayesian kernel machine regression (BKMR) and Quantile g-computation models. A causal mediation effect model was performed to estimate the average indirect impact of PFAS, mediated by high-quality embryo rates, on the clinical pregnancy outcomes, as well as its direct impact representing all other causal effects. Spearman's rank correlation coefficient was used to identify the associations between the differentially expressed metabolites and the high-quality embryo rates. The detection frequencies of 15 PFAS exceeded 85%, and perfluorooctanoic acid (PFOA) had the highest median concentration (6.54 ng/mL). The PFAS mixture was negatively associated with the high-quality embryo rate, and PFOA was the major contributor (conditional posterior inclusion probability = 0.97295). PFAS was also negatively associated with the clinical pregnancy outcome, and the causal mediation analysis revealed that the embryo quality potentially mediated the relationship between the clinical pregnancy outcome with PFOA (proportion mediated: 0.181, 95% CI: 0.024, 0.755), Perfluoro-n-nonanoic acid (PFNA, proportion mediated: 0.148, 95% CI: 0.022, 0.656), or Perfluoro-n-tridecanoic acid (PFTrDA, proportion mediated: 0.130, 95% CI: 0.005, 0.693). The decreased organonitrogens (Pro-Trp and lauryldimethylamine oxide) and sphingolipids metabolites (phytosphingosine, N-myristoylsphinganine and N-lauroyl-d-erythro-sphinganine) in the follicular fluid were associated with PFOA related-poor embryo quality. High exposure to follicular fluid PFAS was negatively correlated with embryo quality during ART, with PFOA likely to be the major contributor. PFOA-related poor embryo quality was associated with the reduction of organonitrogens and sphingolipids metabolites that are crucial for the maintenance of normal cell growth and metabolism. https://doi.org/10.1289/EHP15422.
Circulating interferon alpha protein measured with digital ELISA as a biomarker for modified Rodnan skin score progression in limited systemic sclerosis: comment on the article from Di Donato et al
Authors: Carine Schmidt, François Maillet, Vincent Bondet, Darragh Duffy, Luc Mouthon, Benjamin Chaigne, Mathieu P Rodero
Journal: Arthritis & Rheumatology (2025)

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Temporal changes in survival among adult patients with chronic myeloid leukemia in the period 1995–2022—a Danish nationwide population-based register study
Authors: Sofie Solhøj Jønsson, Sofie Amalie Sørensen, Jonas Faartoft Jensen, Eva Futtrup Maksten, Gitte Thomsen, Ditte Rechter Zenas, Maren Poulsgaard Jørgensen, Andreja Dimitrijevic, Marianne Tang Severinsen
Journal: Blood Cancer Journal (2025)
The ratio of brain to liver glucose activity and disease activity in multiple myeloma
Authors: Sarah Dingli, Paul Rothweiler, Moritz Binder, Joselle Cook, Morie A Gertz, Suzanne Hayman, Prashant Kapoor, Taxiarchis Kourelis, Shaji K Kumar, Mustaqeem Siddiqui, Rahma Warsame, Yi Lin, Arthur G Erdman, David Dingli
Journal: Blood Cancer Journal (2025)
Universal Hydrogel Carrier Enhances Bone Graft Success: Preclinical and Clinical Evaluation (Adv. Healthcare Mater. 12/2025)
Authors: Dax Calder, Farshad Oveissi, Simin Maleknia, Tom Huang, Bernard Koong, Terence Abrams, Andrew Oar, Wojciech Chrzanowski, Fariba Dehghani, Ali Fathi
Journal: Advanced Healthcare Materials (2025)
Advances in treatments for acute ischemic stroke
Authors: Richa Sharma, Kun Lee
Journal: BMJ (2025)

ABSTRACT Acute ischemic stroke is a leading global cause of death and disability. Intravenous thrombolysis was the first acute treatment developed for ischemic strokes. First with alteplase and now with tenecteplase, intravenous thrombolysis has remained a cornerstone of acute ischemic stroke management. In large vessel occlusions, endovascular thrombectomy has become the standard of care in acute stroke management for anterior and posterior circulation strokes. The boundaries for these treatments have expanded, which has improved outcomes in patients who were previously ineligible. This review summarizes the latest advances in interventions for acute ischemic stroke, extending beyond existing guidelines and review articles to explore emerging strategies and treatments currently under investigation.
Comparing the role of relative and absolute humidity in heat-related mortality: A case time series study in South Korea
Authors: Jieun Min, Whanhee Lee, Jieun Oh, Cinoo Kang, Eunhee Ha
Journal: Environmental Health Perspectives (2025)

Despite strong physiological plausibility, epidemiology studies have reported inconsistent associations of humidity with heat-related health outcomes. In this regard, there has been a heated debate on which humidity metric to use in epidemiological research. This study aimed to compare the role of two common humidity metrics, relative and absolute humidity, in heat-related mortality in summer using a nationwide mortality dataset. We applied a case time-series design for summer (June to September) mortality across the entire 229 districts of South Korea from 2011 to 2019. The temperature was fitted using a distributed lag non-linear model (DLNM) with 10 lag days. A linear interaction between the cross-basis of temperature and humidity was included in each model to examine the different patterns of association between heat and mortality by humidity level (low and high humidity defined by 5th and 95th percentile of each humidity distribution). A total of 780,102 deaths were recorded in the summer from 2011 to 2019, in South Korea. The association between extreme heat (temperature approximately above the 99th percentile of the temperature distribution) and mortality was modified more by absolute humidity than by relative humidity, although the effect modification of both humidity indicators was not statistically significant. The relative risks (95% confidence interval) at the 99.9th percentile temperature compared to the minimum mortality temperature were 1.21 (1.11, 1.31) and 1.22 (1.03, 1.44) for low and high relative humidity, respectively, and 1.11 (0.89, 1.37) and 1.25 (1.15, 1.34) for low and high absolute humidity, respectively. Our findings provide epidemiological evidence on the role of relative and absolute humidity in heat-related mortality and suggest that absolute humidity may be more appropriate metric than relative humidity when assessing health impact.. https://doi.org/10.1289/EHP15827.
Localized Hydrogel Microspheres for Osteoarthritis Treatment: Recruitment and Differentiation of Stem Cells (Adv. Healthcare Mater. 12/2025)
Authors: Qiming Pang, Zhuolin Chen, Jingdi Zhan, Jiacheng Liu, Junyan Liu, Weikang Zhao, Wei Huang, Lili Dong
Journal: Advanced Healthcare Materials (2025)
Probiotic‐Based Mineralized Living Materials to Produce Antimicrobial Yogurts (Adv. Healthcare Mater. 12/2025)
Authors: Gloria B. Ramírez‐Rodríguez, Laura Sabio, Laura Cerezo‐Collado, Víctor Garcés, Jose M. Domínguez‐Vera, José M. Delgado‐López
Journal: Advanced Healthcare Materials (2025)
Galvanic Cell‐Stimulated Mesenchymal Stem Cell Mesh for Enhanced Pelvic Organ Prolapse Treatment (Adv. Healthcare Mater. 12/2025)
Authors: Ao Xiao, Jian Wang, Xi Chen, Han Wu, Xinran Jiang, Yaqin Zhao, Zhenzhen Wu, Chen Wang, Xingfu Wei, Yannan Sheng, Jiali Niu, Yongyan Hu, Haixiang Su, Qing Liu, Lingqian Chang
Journal: Advanced Healthcare Materials (2025)
Histologic Features Associated with Kidney Survival in Scleroderma Renal Crisis
Authors: Yannick Binois, David Buob, Marie-Sophie Meuleman, Idris Boudhabhay, Pierre Isnard, Marion Rabant, Viviane Gnemmi, Laurent Daniel, Isabelle Brocheriou, Clement Gosset, Marie Frimat, Thomas Quémeneur, Rafik Mesbah, Noemie Jourde-Chiche, Olivier Moranne, Pierre Housset, Emmanuel Esteve, Alexis Mathian, Sebastien Rivière, Aurélie Hummel, Luc Mouthon, Benjamin Chaigne, Anne Lyse Langlois, Eric Thervet, Olivier Aubert, Lubka Roumenina, Sophie Chauvet, Alexandre Karras, Jean-Paul Duong-Van-Huyen
Journal: Journal of the American Society of Nephrology (2025)

Background: Scleroderma renal crisis is a severe complication of systemic sclerosis that is associated with higher morbidity and mortality. However, limited data are currently available regarding the factors affecting renal outcome during scleroderma renal crisis. The objective of this study is to describe renal histopathology in scleroderma renal crisis and to evaluate its association with kidney failure. Methods: We performed a French multicenter retrospective study that included 65 patients who underwent a kidney biopsy in the context of scleroderma renal crisis, between 2006 and 2020. Non-supervised hierarchical cluster analysis was used to identify histologic patterns. Cox model was performed to estimate the hazard ratios associated with histologic parameters for kidney failure, defined as the need for long-term dialysis therapy of or eGFR &lt;15 ml/min/1.73m2 at last follow-up. Multiplexed sequential Immunofluorescence and proximity ligation assay was used in kidney biopsies to analyze complement system activation. Results: Renal pathology in scleroderma renal crisis was more heterogeneous than expected, with 3 histological patterns of kidney injury identified by cluster analysis. Multivariable analysis showed that together with creatinine at presentation, acute arteriolar thrombotic microangiopathy and onion skinning in small arteries were independently associated with the risk of kidney failure. Multiplex immunofluorescence identified fractions from the complement classical pathway in arterioles and arteries in scleroderma renal crisis, while proximity ligation experiments confirmed the in situ activation of classical pathway C3 convertase. Complement terminal pathway fraction C5b-9 was localized in injured arteries. Conclusions: This study shows that the clinical definition of scleroderma renal crisis encompasses heterogeneity in the patterns of kidney injury. Acute arteriolar thrombotic microangiopathy and onion skinning were associated with kidney failure. Complement system was activated in these injured vessels
Delphi Panel for the Development of Diagnostic Criteria for Metastatic Cutaneous Crohn Disease
Authors: Joseph Ebriani, Karla Santiago-Soltero, Ellen E. Anshelevich, Rahul S. Dalal, Bridget Shields, Alexandra Charrow, Manasi Agrawal, Afsaneh Alavi, Susan Burgin, Ahuva Cices, Alexandra J. Coromilas, Edward W. Cowen, Noah Goldfarb, Jennifer L. Hsiao, Jean S. McGee, Alex G. Ortega-Loayza, Martina Porter, Misha Rosenbach, Katharina S. Shaw, Karolyn A. Wanat, Alice J. Watson, Serre-Yu Wong
Journal: JAMA Dermatology (2025)

Importance Metastatic cutaneous Crohn disease (MCD) is a rare condition for which there are currently no published diagnostic criteria. Formal MCD diagnostic criteria will expand clinical care and research by enabling future diagnostic code validation, crystallizing a more uniform disease entity for the purposes of translational research, and allowing the development of more formalized outcome measures aimed at treatment response. Objective To define a set of criteria for the diagnosis of MCD. Evidence Review In this consensus statement, a panel of experts on MCD and related conditions was assembled. Their opinions were gathered regarding the clinical and histologic findings that are sufficient, necessary, and highly suggestive of MCD through serial survey. Subsequent surveys were continued until consensus was achieved. Sufficient was defined as a feature that, if noted, would enable diagnosis of MCD without any other signs, symptoms, or testing. Necessary was defined as a feature that must be present to establish a diagnosis of MCD. Highly suggestive referred to any other features that were indicative of MCD but did not qualify as sufficient or necessary to diagnose MCD. Findings Of 24 experts invited, 19 agreed to participate, with a 79% to 100% response rate across 5 rounds conducted. Five patients were also invited to participate, but none opted to participate, citing lack of clinical expertise and time concerns. The experts were all from the US; 5 (26%) have practiced medicine for 0 to 5 years, 5 (26%) practiced for 6 to 10 years, 6 (32%) practiced for 11 to 15 years, and 3 (16%) practiced for more than 20 years. A total of 18 experts (95%) worked in an academic practice setting. There was consensus agreement that MCD could present as oral disease, genital disease, or, rarely, in another location. Consensus was achieved on 2 major and 5 minor criteria for genital/other subtypes of MCD and 5 minor criteria for oral MCD. There was consensus that, while there are some pathological findings that are highly suggestive of MCD, histologic criteria are not necessary for diagnosis. Conclusions and Relevance A panel of experts reached consensus on the diagnostic criteria for MCD described in this study. These criteria include major and minor clinical criteria, along with histopathological criteria for the diagnosis of genital and oral MCD. This consensus is a crucial step in the diagnosis of and future treatment development for MCD, a rare and clinically understudied condition.