tbuckley/cabot-search huggingface dataset:
Cord Blood Allograft Rejection Mediated By Coordinated Donor-Specific Cellular and Humoral Immune Processes
Authors: Ryo Hanajiri, Makoto Murata, Kyoko Sugimoto, Miho Murase, Haruhiko Ohashi, Tatsunori Goto, Keisuke Watanabe, Nobuhiko Imahashi, Seitaro Terakura, Tetsuya Nishida, Tomoki Naoe
Journal: Blood (2013)
Abstract 8087: Association of Left Ventricular Mechanical Dyssynchrony with Outcomes in Ischemic Cardiomyopathy: A Follow-up Study of 587 Patients Undergoing Gated Positron Emission Tomography
Authors: Wael Aljaroudi, M Chadi Alraies, Wael A Jaber, Zoran Popovick, Richard Brunken, Manuel D Cerqueira, Thomas Marwick
Journal: Circulation (2011)

Background: We sought to assess the independent contribution of left ventricular (LV) dyssynchrony to prognosis in patients with ischemic cardiomyopathy (ICM). Methods and Results: Stress/rest Rb-82 gated PET imaging was performed in consecutive patients with ICM and LV ejection fraction (EF) ≤35% (age 66±11 years, 83% men) between 2006 and 2010. Excluding those with CRT, 587 patients were followed for cardiac and all-cause mortality for 1.9±1.4 years. The mean phase dyssynchrony index (standard deviation [SD] 50±21°) was higher than that of a normal group (13±4°, P&lt;0.0001). Of 95 cardiac deaths (16%), 70% were from pump failure, 18% from arrhythmias and 12% from coronary artery disease. Using a SD cut-off of 43° to define dyssynchrony, patients with SD≥43° (n=339) had poorer outcomes than those with SD&lt;43° (cardiac death 19% vs. 12%, p=0.02). However, Cox analysis showed survival to be independently associated with age (HR 1.05 [95%CI 1.03-1.07]), diabetes (1.7[1.14-2.57]), mitral regurgitation (1.39[1.11-1.75]), EF (0.95[0.92-0.98]), and fixed perfusion defect size (PDS) (1.15 [1.05-1.25] per 10% increase), but not SD. Similarly, only age, diabetes, heart failure class, EF and fixed PDS were independently associated with all-cause death. Using nested Cox models, LVEF and fixed PDS added significant information for the prediction of outcome while phase SD did not (Figure 1). Finally, patients with large scar burden (fixed PDS ≥40%) had worse outcome independent of SD (Figure 2). Conclusion: In patients with ICM, the association of LV dyssynchrony with cardiac death appears to derive from advanced age, diabetes, mitral regurgitation, scar burden and lower LVEF, but not SD.
Abstract 4099: Elevated Campesterol Serum Levels - a Significant Predictor of Incident Myocardial Infarction: Results of the Population-based MONICA/KORA Follow-up Study 1994 to 2005
Authors: Joachim Thiery, Uta Ceglarek, Georg Martin Fiedler, Alexander Leichtle, Sven Baumann, Daniel Teupser, Olga Lang, Jens Baumert, Christa Meisinger, Hannelore Loewel, Angela Doering
Journal: Circulation (2006)

The increasing use of “functional foods” supplemented with plant sterols to lower serum cholesterol levels and on the other hand the discovery of the rare ABCG5/G8 mutation resulting in high phytos...
RECURRENT PNEUMOCOCCIC MENINGITIS TREATED WITH SULFONAMIDES: CASE REPORT
Authors: Henry Hopkins, L. C. Hatch, H. P. Schenck, D. S. Pepper
Journal: Annals of Internal Medicine (1944)

Case Reports1 February 1944RECURRENT PNEUMOCOCCIC MENINGITIS TREATED WITH SULFONAMIDES: CASE REPORTHENRY HOPKINS, M.D., L. C. HATCH, M.D., H. P. SCHENCK, M.D., D. S. PEPPER, M.D., F.A.C.P.HENRY HOPKINS, M.D.Search for more papers by this author, L. C. HATCH, M.D.Search for more papers by this author, H. P. SCHENCK, M.D.Search for more papers by this author, D. S. PEPPER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-2-333 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrior to the introduction of the sulfonamide group of drugs, pneumococcic meningitis was almost invariably fatal. Prior to 1937 there were 185 reported cures. Since the introduction of these drugs, there have been more than that number of reported cures. We have recently used sulfapyridine and sulfathiazole in the treatment of a patient who had three attacks of pneumococcic meningitis following acute sinusitis. We have been unable to find any similar case reported. Elvidge and Roseman1used sulfapyridine successfully in treating a patient who had three attacks of meningitis following a skull fracture. Craddock and Bowers'2patient had four episodes...Bibliography1. ELVIDGEROSEMAN ARE: Recurrent pneumococcic meningitis complicating skull fracture, Canad. Med. Assoc. Jr., 1940, xlii, 460. Google Scholar2. CRADDOCKBOWERS GBRV: Recurrent pneumococcic meningitis treated with sulfapyridine, Jr. Am. Med. Assoc., 1941, cxvi, 296-298. CrossrefGoogle Scholar3. SPINKHANSEN WWAE: Sulfathiazole: clinical evaluation, Jr. Am. Med. Assoc., 1940, cxv, 840-847. CrossrefGoogle Scholar4. SADUSKBLAKESEYMOUR JFFGA: Observations on the absorption, excretion, diffusion, and acetylation of sulfathiazole in man, Yale Jr. Biol. and Med., 1940, xii, 681-696. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication August 27, 1941.From the Medical Division of the Hospital of the University of Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPNEUMOCOCCAL MENINGITIS — A KILLING DISEASEFour recurrent attacks of pneumococcus meningitiswith recoveryThe treatment of pneumococcal meningitis 1 February 1944Volume 20, Issue 2Page: 333-339KeywordsDrugsMeningitisPatientsSkullSulfonamide ePublished: 1 December 2008 Issue Published: 1 February 1944 PDF downloadLoading ...
INDUSTRIAL HYGIENE IN THE NATIONAL DEFENSE PROGRAM
Authors: J. J. Bloomfield
Journal: Annals of Internal Medicine (1941)

Excerpt Today it is acknowledged that military mobilization and expansion are impossible without industrial mobilization and expansion. We know that steps to perfect the Nation's industrial mobilization are being taken every day, and that any condition which tends to retard efficient production of defense materials is considered of major importance. We know that the industrial expansion now in progress brings in its wake numerous health problems affecting the working population. Do these health problems have any significant effect on the rate and quality of our industrial production? If so, what provisions are being made today to solve these problems? EFFECT OF
Abstract 6087: Fragmented QRS Complex on 12-lead ECG Developed During the First 48 Hours after Acute Myocardial Infarction Predicts Mortality
Authors: Mithilesh K Das, Mark A Michael, Hussam Suradi
Journal: Circulation (2008)

Fragmented QRS complex (fQRS) signifies myocardial infarction (MI) scar. Myocardial scar acts as a substrate for ventricular arrhythmias and a risk for death. We postulated that the development of new fQRS during the first 48 hours after an acute MI signifies mortality. Serial ECGs of 896 pts with acute coronary syndrome (ACS) and their mortality during follow-up were studied. MI was diagnosed by history, ECG and elevated cardiac enzymes. Serial ECGs were recorded at presentation, 8 hours, 16 hours and 24 – 48 hours. The fQRS on 12-lead ECG was defined by the presence of fragmented QRS, notched R or S wave, or RSR′ pattern without any bundle branch block, in at least 2 contiguous leads in one of the coronary artery territories (LAD: lead V1 to V6, LCx: lead I, aVL and V6, and RCA: lead II, III and aVF). The MI group (n =441, 98.4% males, age 63±11 yrs) and the control (unstable angina) group (n=455, 97.1% males, age 61±11 yrs, P=NS). 104 (24%) patients had STMI and 337 (76%) patients had NSTMI. fQRS developed in a significantly higher number of patients in the MI group as compared to the control group (224 [50.8%] vs. 17 [3.7%], p&lt;0.001), respectively. New Q-waves developed in 122 (27.7%) and 2 (0.4%) patients in MI group and control group, respectively. fQRS was a multivariate predictor of mortality in ACS group as well as in the MI group, whereas Q wave did not predict mortality during a 23+/−17 months of follow-up. Kaplan-Meier survival curve revealed a significantly higher mortality in fQRS vs. non-fQRS group (p=0.001),. The development of fQRS within the first 48 hours of ACS patients predicts mortality during follow-up in patients with MI.
Individualization in Clinical Medicine
Authors: Julius Bauer
Journal: Annals of Internal Medicine (1928)

Article1 August 1928Individualization in Clinical MedicineJULIUS BAUER, M.D.JULIUS BAUER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-2-127 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMr. President, ladies and gentlemen: Before entering upon the subject of my convocation address I feel indebted to give you the assurance of my deep and respectful appreciation. It is a great honour not only to myself, but also to our old medical school of Vienna that one of its younger members was selected this year by the Board of Regents of the American College of Physicians to be its guest at the Annual Meeting and to deliver the Convocation Address. Concerning the subject of this address I thought it would meet with your approval not to talk about a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Vienna Austria*Convocation Address, New Orleans meeting, March 9, 1928. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1928Volume 2, Issue 2Page: 127-137 ePublished: 1 December 2008 Issue Published: 1 August 1928 PDF downloadLoading ...
Abstract 16120: PDZ Domain-Binding Motif of the Cardiac Sodium Channel Nav1.5 Regulates Functional Channel Expression at the Cell Membrane
Authors: Jakob Ogrodnik, Maxime Albesa, Carol Ann Remme, Diana Shy, Bruno Gavillet, Connie Bezzina, Hugues Abriel
Journal: Circulation (2011)

Background: Regulation of cardiac ion channels through their interaction with proteins is an essential aspect of cardiac ion channel function. Previous evidence has implicated PDZ domain-binding mo...
Localized Elevation of Shear Stress Is Related to Coronary Plaque Rupture
Authors: Yusaku Fukumoto, Takafumi Hiro, Takashi Fujii, Genta Hashimoto, Tatsuhiro Fujimura, Jutaro Yamada, Takayuki Okamura, Masunori Matsuzaki
Journal: Journal of the American College of Cardiology (2008)
Public perceptions in relation to intention to receive pandemic influenza vaccination in a random population sample: evidence from a cross-sectional telephone survey
Authors: V Sypsa, T Livanios, M Psichogiou, M Malliori, S Tsiodras, I Nikolakopoulos, A Hatzakis
Journal: Eurosurveillance (2009)

A cross-sectional telephone survey on a nationally representative sample of 1,000 Greek households was performed to assess the acceptability of the pandemic influenza A(H1N1)v vaccine, factors associated with intention to decline and stated reasons for declining vaccination. The survey was initiated the last week of August 2009 (week 35) and is still ongoing (analysis up to week 44). The percentage of participants answering they would probably not/definitely not accept the vaccine increased from 47.1% in week 35 to 63.1% in week 44 (test for trend: p<0.001). More than half of the people which chronic illnesses (53.3%) indicated probably not/definitely not. Factors associated with intention to decline vaccination were female sex, age between 30-64 years, perception of low likelihood of getting infected or of low risk associated with influenza, and absence of household members suffering from chronic illnesses. For the majority of the respondents (59.8%), the main reason for intending to decline vaccination was the belief that the vaccine might not be safe. Promotion of vaccination programmes should be designed taking into account the attitudinal barriers to the pandemic vaccine.
Erratum to “Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis”
Authors: R.J. Moore, D.M. Owens, G. Stamp, C. Arnott, F. Burke, N. East, H. Holdsworth, L. Turner, B. Rollins, M. Pasparakis, G. Kollias, F. Balkwill
Journal: Nature Medicine (1999)
HISTOLOGIC STRUCTURE OF CARCINOMAS OF THE STOMACH AND QUALITY OF GASTRIC SECRETIONS
Authors: Alexander Brunschwig, T. Howard Clarke
Journal: Annals of Internal Medicine (1939)

Article1 December 1939HISTOLOGIC STRUCTURE OF CARCINOMAS OF THE STOMACH AND QUALITY OF GASTRIC SECRETIONSALEXANDER BRUNSCHWIG, M.D., T. HOWARD CLARKE, M.D.ALEXANDER BRUNSCHWIG, M.D.Search for more papers by this author, T. HOWARD CLARKE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-6-1001 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe high incidence of hyposecretion of the stomach, hypochlorhydria and achlorhydria accompanying gastric cancer has long been known. The exact incidence varies in different statistics, and will also vary of course with the age of any group of patients since the frequency of achlorhydria unaccompanied by other apparent abnormalities increases with age.In a group of 70 patients at the University of Chicago Clinics in whom carcinoma of the stomach was verified at operation or necropsy and who were for the most part in middle or advanced age, 38 (59 per cent) exhibited achlorhydria, 11 (16 per cent) exhibited hypochlorhydria...Bibliography1. POLLANDBLOOMFIELD WSAL: Gastric secretion in cancer of the stomach, Bull. Johns Hopkins Hosp., 1930, xlvi, 307. Google Scholar2. IVYGRAY ACJS: Enterogastrone, Cold Spring Harbor Symposia on Quantitative Biology, 1937, v, 405. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication December 10, 1938.From the Department of Surgery and the Division of Roentgenology of the Department of Medicine, University of Chicago.This work was conducted as part of a study on the Effects of Extracts from Human Cancerous Stomachs on the Secretions of Gastric Juice in Dogs, supported by a grant from the International Cancer Research Foundation, Philadelphia, Pennsylvania.†Research Assistant, International Cancer Research Foundation Fund. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1939Volume 13, Issue 6Page: 1001-1004KeywordsAchlorhydriaGastric cancerResearch fundingStomachSurgery ePublished: 1 December 2008 Issue Published: 1 December 1939 PDF downloadLoading ...
Abstract 5069: Atorvastatin/Fenofibrate 40/100 mg Fixed-Dose Combination Tablet (LCP-AtorFen 40/100 mg) Offers Improved Efficacy Over 40 mg Atorvastatin and Higher Dose 145 mg Fenofibrate in Patients with Dyslipidemia
Authors: Michael H Davidson, Michael Rooney, Joan Drucker, H E Griffin, Michael Beckert
Journal: Circulation (2008)

This was a multicenter, randomized, double-blind study comparing the efficacy and safety of a fixed-dose combination tablet of atorvastatin/fenofibrate 40/100 mg (LCP-AtorFen 40/100 mg), 40 mg ator...
PRIMARY CARCINOMA OF THE LIVER: REPORT OF 20 CASES, INCLUDING TWO TREATED WITH TRIETHYLENE MELAMINE
Authors: H M WILSON
Journal: Annals of Internal Medicine (1954)

Article1 July 1954PRIMARY CARCINOMA OF THE LIVER: REPORT OF 20 CASES, INCLUDING TWO TREATED WITH TRIETHYLENE MELAMINEHENRY M. WILSON, M.D.HENRY M. WILSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-1-118 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwenty cases of primary carcinoma of the liver have been found in 35,995 admissions to this hospital in the last 10 years. Twelve of these patients had hepatomas, or liver cell tumors, while six had cholangiomas, or bile duct cell tumors, and two had atypical or mixed types. The ratio of hepatomas to cholangiomas, therefore, was 2:1, which agrees with the ratio given by Bockus.1 Ten of these 20 patients (seven of the hepatoma group and three of the cholangioma group) also had cirrhosis. Seven were white males and 13 were Negro males.Since primary carcinomas of the liver grow...Bibliography1. Bockus HL: Gastro-enterology, Vol. 3, 1946, W. B. Saunders Co., Philadelphia, p. 357. Google Scholar2. LewisCrossley MRML: Retardation of tumor growth in mice by oral administration of ethylenimine derivatives, Arch. Biochem. 26: 319, 1950. MedlineGoogle Scholar3. KarnofskyBurchenalArmisteadSouthamBernsteinCraverRhoads DAJHGCCMJLLFCP: Triethylene melamine in the treatment of neoplastic disease; a compound with nitrogen mustard-like activity suitable for oral and intravenous use, Arch. Int. Med. 87: 477, 1951. CrossrefGoogle Scholar4. BurtnerJensenRumball OWLCJM: Triethylene melamine in the treatment of lymphomas and other neoplastic diseases, Ann. Int. Med. 38: 1222, 1953. LinkGoogle Scholar5. Ruegsegger JM: Personal communication. Google Scholar6. StrongPittsMcPhee GFHHJG: Primary carcinoma of the liver—25 year study, Ann. Int. Med. 30: 791, 1949. LinkGoogle Scholar7. Goldenberg IS: Carcinoma of the biliary tract, Am. J. Surg. 86: 292, 1953. CrossrefMedlineGoogle Scholar8. Lemmer KE: Primary carcinoma of the liver, Arch. Surg. 61: 599, 1950. CrossrefGoogle Scholar9. Gustafson EG: An analysis of 62 cases of primary carcinoma of the liver, Ann. Int. Med. 11: 889, 1937. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Peoria, Illinois*Received for publication December 28, 1953.The triethylene melamine was furnished by J. M. Ruegsegger, M.D., Lederle Laboratories, Pearl River, N. Y.From the Medical Service, Veterans Administration Hospital, Alexandria, Louisiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDNA Alkylating Agents 1 July 1954Volume 41, Issue 1Page: 118-123KeywordsBile ductsCirrhosisHepatocellular carcinomaLiverMedical servicesPathologistsRivers Issue Published: 1 July 1954 PDF downloadLoading ...
Drug treatment for benign prostatic hyperplasia
Authors: R. Mendelsohn, D. Thompson, G. N Collins, S Taneja
Journal: BMJ (1997)

Superficial analysis ignores evidence on efficacy of treatmentEditor-The conclusions of John Wright and colleagues have the potential to jeopardise public health as well as patients' care; their systematic review lacks the necessary depth and understanding of the issues. 1he authors note that sleep apnoea is currently viewed as a public health concern because it is prevalent and thought to be associated with morbidity and mortality.The collective evidence from the studies included in the review supports this view; the authors' conclusions that evidence for the health effects of sleep apnoea is "weak or contradictory" and that "the relevance of sleep apnoea to public health has been exaggerated" are disturbing.The authors seem to have misinterpreted the findings of some studies.In their assessment of nine studies of hypertension judged to be methodologically adequate, the authors dismiss seven studies that show an independent association between sleep apnoea and hypertension.
Abstract 8562: Lower Survival after Drug-eluting Stents than Coronary Artery Bypass Grafting for Unprotected Left Main and/or Multivessel Disease: A Meta-analysis of Randomized Trials and Risk-adjusted Observational Comparative Studies
Authors: Shin-nosuke Goto, Hisato Takagi
Journal: Circulation (2011)

Backgrounds: Previous meta-analyses of raw data from randomized trials and observational comparative studies have demonstrated no significant difference in survival between drug-eluting stents (DES) and coronary artery bypass grafting (CABG) for patients with unprotected left main (ULMD) and/or multivesssel disease (MVD) (double-vessel [2VD] and triple-vessel disease [3VD]). Raw data from observational studies, however, are unadjusted and susceptible to confounding. Methods: To attempt to control for confounding in observational studies, we performed a meta-analysis of randomized trials and risk-adjusted observational comparative studies (providing adjusted hazard ratios [HRs] using propensity score and/or multivariate Cox proportional hazards regression analyses) of DES versus CABG for survival in patients with ULMD and/or MVD. Study-specific estimates were combined in a random-effects model. Results: Our comprehensive search identified 3 randomized trials and 21 risk-adjusted observational comparative studies. Pooled analysis of 32 HRs for all-cause death from all studies (36,574 patients) demonstrated a significantly higher mortality with DES than CABG (HR, 1.22; 95% confidence interval [CI], 1.04-1.42; P=0.01). Exclusion of any single HR from the analysis did not substantively alter the overall results of our analysis. When data were pooled separately in MVD (both 2VD and 3VD)-studies (31,325 patients) and ULMD-studies (4,214 patients), DES were associated with a significantly higher mortality than CABG for MVD (HR, 1.34; 95% CI, 1.11-1.61; P=0.002), not for ULMD (HR, 0.93; 95% CI, 0.69-1.25; P=0.74). Separately pooled analysis of 3VD-studies (14,196 patients) and 2VD-studies (15,137 patients) demonstrated a significantly higher mortality with DES than CABG for 3VD (HR, 1.49; 95% CI, 1.17-1.89; P=0.001), not for 2VD (HR, 1.25; 95% CI, 0.82-1.89; P=0.29). Conclusions: The present meta-analysis of randomized trials and risk-adjusted observational comparative studies suggests that DES are associated with lower survival than CABG for high-risk (ULMD and/or MVD) patients, mainly due to lower survival for patients with 3VD.
Abstract 15441: Effect of Corticosteroid Therapy on Ventricular Arrhythmias in Patients with Cardiac Sarcoidosis
Authors: Kenji Yodogawa, Yoshihiko Seino, Toshihiko Ohara, Hideo Takayama, Takao Katoh, Kyoichi Mizuno
Journal: Circulation (2010)

Background: Ventricular arrhythmias are one of the main causes of sudden death in cardiac sarcoidosis (CS). Little is known about the efficacy of corticosteroid therapy for ventricular arrhythmias ...