tbuckley/cabot-search huggingface dataset:
Abstract 3810: Antiviral RNA Interference Mediated by a Recombinant Cardiotropic AAV9 Vector Improves Cardiac Function in Coxsackievirus B3 Cardiomyopathy
Authors: Wolfgang Poller, Isaac Sipo, Dirk Westermann, Jens Kurreck, Roland Vetter, Xiaomin Wang, Lennart Suckau, Heinz Zeichhardt, Sandra Pinkert, Volker Erdmann, Carsten Tschope, Henry Fechner
Journal: Circulation (2008)

RNA interference (RNAi) has potential to be a novel therapeutic strategy in diverse areas of medicine. We report here on targeted RNAi for the treatment of a viral cardiomyopathy which is a major cause of sudden cardiac death or terminal heart failure in children and young adults. RNAi therapy employs small regulatory RNAs to achieve its effect but in vivo use of synthetic small interfering RNAs is limited by instability in plasma and low transfer into target cells. We instead evaluated an RNAi strategy using short hairpin RNA (shRdRp) directed at the RNA polymerase (RdRP) of Coxsackievirus B3 (CoxB3) in HeLa cells, primary rat cardiomyocytes (PNCMs), and CoxB3-infected mice in vivo. A conventional AAV2 vector expressing shRdRp protected HeLa against virus-induced death, but this vector type was unable to transduce PNCMs. In contrast, an analogous pseudotyped AAV2.6 vector was protective also in PNCMs and reduced virus replication by &gt;3 log10 steps. Finally, we evaluated intravenous treatment of mice with an AAV2.9-shRdRp vector since AAV9 carries the most cardiotropic AAV capsid currently known for in vivo use. Mice with CoxB3 cardiomyopathy had disturbed left ventricular (LV) function with impaired parameters of contractility (dP/dtmax 3006±287 vs. 7482±487 mmHg/s, p&lt;0.01) and diastolic relaxation (dP/dtmin -2224±195 vs. -6456±356 mmHg/s, p&lt;0.01 and Tau 16.2±1.1 vs. 10.7±0.6 ms, p&lt;0.01) as compared to control mice. AAV2.9-shRdRp treatment significantly attenuated the cardiac dysfunction compared to control vector-treated mice on day 10 after CoxB3 infection: dP/dtmax 3865±354 vs. 3006±287 mmHg/s (p&lt;0.05) and dP/dtmin -3245±231 vs. −2224±195, mmHg/s (p&lt;0.05), and Tau 11.9±0.5 vs. 16.2±1.1 ms (p&lt;0.01). The data show, for the first time, that intravenously injected AAV9 has the potential to target RNAi to the heart and suggest AAV9-shRNA vectors as a novel therapeutic approach for cardiac disorders.
Locoregional pain treatment. Troubles and prospectives: antalgic radiotherapy.
Authors: G Mantini, M Campitelli, M Balducci, S Manfrida, V Valentini, A Turriziani, A G Morganti, A Scopa, N Cellini
Journal: Journal of experimental & clinical cancer research (2003)

Pain control in patients with cancer represents a significant aspect of radiation therapy practice. Radiation therapy is one of the most effective, and often the only, therapeutic option to relieve pain caused by nerve compression or infiltration by malignant tumor, pain from liver and bony metastases and it provides also successful palliation of dysphagia caused by oesophageal carcinoma and of pain due to pancreatic cancer. Various instruments are avaliable for pain evaluation but a valid methodology to assess the pain status in the patient with cronic cancer pain is still an important clinical problem. In this complex and wide scene this contribution wants to confirm the role of radiotherapy in cancer pain control, in paricular in bone metastases, and to involve the patient himself in the survey of radiation treatement response by a subjective evaluation of bone pain, elaborating a reliable and valid unidimensional method by which recording the self-rating of the patient's sensation. Materials and Methods For the subjective evaluation of pain caused by bone metastases we used an application form with which drawing information in the course of time in terms of: response to the treatment, duration of symptom relief and quality of life. Results Considering as cut-off a dose of 30 Gy, which is commonly considered the conventional treatment for bone metastases, the partial and complete response were, respectively, of 54% and 30% in the patients treated with dose higher than or equal to 30 Gy, and 60% and 20% in the ones treated with doses lower than 30 Gy. In the whole, in 84 patients, the global response was of 82%, in accordance with literature. Conclusion In this retrospective study, the analysis of patient's subjective experience confirmed the effectiveness of radiotherapy in reducing pain caused by bone metastases and in improving quality of life of the patient himself. Given the conflicting opinions on low-dose short-course radiotherapy versus prolonged or higher dose schedules on initial pain relief, we are going to define categories of homogenous patients on whom starting treatment schedules with the aim or of palliation of the symptom or of the functional restitutio, on the base of the expectation and the quality of life.
“European CDC” Moves Forward
Authors: Xavier Bosch
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2130: Long-term Outcomes of Adult Atrial Septal Defect With Severe Pulmonary Hypertension After Surgical Closure
Authors: Jeong-Hoon Kim, Duk-Hyun Kang, Jong-Young Lee, Jong-Min Song, Tae-Jin Yun, Kee-Joon Choi, Myeong-Ki Hong, Jae-Kwan Song, Seong-Wook Park, Seung-Jung Park
Journal: Circulation (2007)

The benefits of surgical closure has been unclear in adult atrial septal defect (ASD) with severe pulmonary hypertension (PHT), and we tried to evaluate improvement of PHT and long-term survival after surgical closure compared to medical follow-up. Methods: From 1996 to 2006, we included a total of 71 adult ASD patients (age; 43±15 years) with severe PHT documented by echocardiography. The inclusion criteria were defined as ASD diameter &gt; 15 mm, enlarged right ventricle, and the baseline peak velocity of tricuspid regurgitation (TR) ≥ 4.0 m/sec. We excluded 5 patients with Eisenmenger syndrome documented by cardiac catheterization. Surgical closure was performed on 55 patients (OP group) and the remaining 16 patients were followed up medically (MED group). The improvement of PHT was defined as TR velocity ≤ 3.5 m/sec on follow-up echo. Results: Baseline characteristics and clinical results were compared between the two groups in table . There were no significant differences in terms of gender, ASD diameter, cardiac rhythm, and TR velocity, but the MED group was significantly older. During follow-up of 46±33 months, there were 5 deaths in the MED group and no operative or late death in the OP group, and the 5-year actuarial survival rate of the OP group was significantly higher than the MED group (58±15%, p&lt;0.05). On subgroup analysis according to age, the OP group showed significantly better survival rates than the MED group (p&lt;0.05) in elderly patients (age &gt; 50). In the OP group, TR velocity was significantly decreased from 4.5±0.4 to 3.0±0.7 m/sec on follow-up echo, and improvement of PHT was observed in 47 (85%) patients. On multivariate analysis, female gender and lower baseline TR velocity were the significant independent predictors of improved PHT after surgery. Conclusions: In adult ASD with severe PHT, surgical closure can be safely performed and improve PHT effectively. Especially in elderly patients, ASD closure is significantly related with the better survival rates.
VAMP-7 Interacts With The Actin Cytoskeleton To Control Platelet Spreading and Mediate α-Granule Exocytosis During Thrombus Formation
Authors: Secil Koseoglu, Jennifer L Fitch-Tewfik, Christian G. Peters, Lydia Danglot, Thierry Galli, Robert C. Flaumenhaft
Journal: Blood (2013)
Abstract 13323: Transgenic Overexpression of Snf1-Related Kinase in the Heart Improves Cardiac Metabolic Efficiency and Resistance to Myocardial Ischemia
Authors: Amy Rines, Michael A Burke, Rongxue Wu, E. Dale Abel, Hossein Ardehali
Journal: Circulation (2012)

Introduction: Snf1-related Kinase (SNRK) is a serine/threonine kinase with sequence similarity to AMP-activated protein kinase, but its function is unknown. We found that SNRK is increased in heart...
Remuneration
Authors: M. Therese Southgate
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3785: Is Diastolic Dyssynchrony More Important Determinant Than Systolic Dyssynchrony for the Cardiac Resynchronization Therapy (CRT)? A Study Using Gated Myocardial Perfusion SPECT
Authors: Miyuki Ando, Takeshi Yamamoto, Yukio Saiki, Akihiro Hino, Masunori Matsuzaki
Journal: Circulation (2009)

Objective: Left ventricular dyssynchrony(LV-DS) is one of the most important abnormalities to be corrected by CRT in patients with severe heart failure. However, little is known about the clinical ...
Hantavirus pulmonary syndrome in five pediatric patients - four states, 2009.
Authors: C. Levy, K. Gains, V. Crocco, J. Brown, E. Lawaczeck, W. Ray, M. Miller, M. Klaber, A. Doussette, C. Ralston, N. Marsden-Haug, C. Fritz, C. Watson, A. MacNeil, J. Mills, P. E. Rollin, S. Nichol, B. Knust
Journal: MMWR Morbidity and Mortality Weekly Report (2009)
Abstract 15216: Modulation of CETP Activity by Dalcetrapib Increases Pre-{beta}-HDL and Associated Parameters of HDL Functionality: Preclinical and Clinical Evidence
Authors: Eric J Niesor, David Kallend
Journal: Circulation (2011)

Introduction: Dalcetrapib is a cholesteryl ester transfer protein modulator (CETPm) that increases HDL-C, preserves CETP-induced pre-β-HDL formation, and promotes ATP-binding cassette transporter A...
Trial of d-alpha-tocopherol in Huntington's disease
Authors: C E Peyser, M Folstein, G A Chase, S Starkstein, J Brandt, J R Cockrell, F Bylsma, J T Coyle, P R McHugh, S E Folstein
Journal: American Journal of Psychiatry (1995)

Evidence suggests that the neuropathology of Huntington's disease, a neuropsychiatric disorder due to a mutation on chromosome 4, results from excessive activation of glutamate-gated ion channels, which kills neurons by oxidative stress. Therefore, the authors hypothesized that alpha-tocopherol, which reduces oxyradical damage to cell membranes, might slow the course of Huntington's disease.A prospective, double-blind; placebo-controlled study of high-dose d-alpha-tocopherol treatment was carried out with a cohort of 73 patients with Huntington's disease who were randomly assigned to either d-alpha-tocopherol or placebo. Patients were monitored for changes in neurologic and neuropsychologic symptoms.Treatment with d-alpha-tocopherol had no effect on neurologic and neuropsychiatric symptoms in the treatment group overall. However, post hoc analysis revealed a significant selective therapeutic effect on neurologic symptoms for patients early in the course of the disorder.Antioxidant therapy may slow the rate of motor decline early in the course of Huntington's disease.
Abstract 3938: Gender Differences in the Relationship Between Family History of Myocardial Infarction and Cardiovascular Disease Risk Factors and Awareness in Young Subjects: the Dallas Heart Study
Authors: Mahesh J Patel, James A de Lemos, Binu Philips, Sabina A Murphy, Darren K McGuire, Amit Khera
Journal: Circulation (2006)

Background: Cardiovascular disease (CVD) awareness is poor in young women. While a family history of MI (FHMI) is a useful marker of CVD risk in young subjects, its relationship to CVD awareness an...
Abstract 12505: New-onset Atrial Fibrillation is an Independent Long-term Risk-factor for Hyperthyroidism
Authors: Christian Selmer, Morten L Hansen, Anne-Marie S Olsen, Jesper Lindhardsen, Jonas B Olsen, Peter R Hansen, Ulla Schmidt, Jens Faber, Ole D Pedersen, Christian Torp-Pedersen, Gunnar H Gislason
Journal: Circulation (2010)

Background: Hyperthyroidism is a well-known risk factor for atrial fibrillation (AF), but it is unknown whether new-onset AF predicts later-occurring hyperthyroidism. Objectives: To examine the long-term risk of hyperthyroidism in patients admitted to hospital with new-onset AF. Methods: All patients admitted with first-time AF in Denmark from 1997 to 2006 and their present and subsequent use of antithyroid medication were identified by individual-level linkage of nationwide registries of hospitalization and drug dispensing from pharmacies. Patients with previous thyroid disease or any thyroid medication were excluded. Development of hyperthyroidism was assessed by treatment initiation of methimazole or propylthiouracil within a 10 year period. Every patient was matched with ten controls in the background population by sex and age and the risk of hyperthyroidism was analyzed by multivariate Cox proportional-hazard models. Results: A total of 139,521 patients with new-onset AF were included (mean age 73.5 ...
Abstract 14084: Echocardiogarphic Epicardial Fat Thickness on One-Year Clinical Outcomes in Patients with Coronary Stenting
Authors: Jin-Sun Park, Sun-Mi Kim, Dai-Yeol Joe, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Gyo-Seung Hwang, Seung-Jea Tahk, Joon-Han Shin
Journal: Circulation (2011)

Background Several studies identified independent clinical predictors of restenosis after coronary stenting including female gender, diabetes, hypertension, smoking, body mass index, multivessel di...
Update: Follow-up study showing post-pandemic decline in hand sanitiser use, New Zealand, December 2009
Authors: S Manning, T Barry, N Wilson, M G Baker
Journal: Eurosurveillance (2010)

This study aimed to measure rates of hand sanitiser use in a hospital entrance foyer four months after a baseline study during New Zealand s influenza pandemic. Of the 743 people observed over one (summer) day in December 2009, 8.2% used the hand sanitiser, which was significantly lower (p<0.0001) than the 18.0% reported in the August (winter) study. Health authorities may need to intensify promotion of hand hygiene to reduce the impact of future influenza pandemic waves.
Abstract 807: Incremental Value of Clinical Data Beyond Claims to Predict 30-Day Outcomes Following Heart Failure Admission: Results From the AHA's Get With the Guidelines-Heart Failure Registry
Authors: Bradley G Hammill, Lesley H Curtis, Gregg C Fonarow, Paul A Heidenreich, Clyde W Yancy, Eric D Peterson, Adrian F Hernandez
Journal: Circulation (2009)
Abstract 673: Adenosine Stress Dual-Energy CT of the Heart for Diagnosing Myocardial Ischemia and Viability Compared With Cardiac MRI and SPECT
Authors: David D Bonnema, B. Ruzsics, Michael Rosenblum, Elisabeth Arnoldi, Joseph Abro, Peter Zwerner, Sal Chiaramida, Uwe Schoepf
Journal: Circulation (2009)
Do dreams have meaning? An empirical inquiry
Authors: Milton Kramer, Robert Hlasny, Gerard Jacobs, Thomas Roth
Journal: American Journal of Psychiatry (1976)

Three judges attempted to sort randomly selected dreams of normal college students and schizophrenic patients according to dreamer, night of occurrence, and sequential order within a night. Sorting was successful at statistically significant levels (which differed for the two groups) for all but the third task. The authors conclude that dreams are, as depth psychologists have assumed, orderly nonrandom events and that they reflect day-to-day changes in the life of an individual. They note that further work is needed to determine whether there is order among dreams of a given night.
Much can still be done
Authors: A. R P Walker, L. T Bourne, B. J Klugman
Journal: BMJ (1996)

EDITOR,—Staffan Bergstrom and Pascoal Mocumbi provide a telling description of the health burdens now confronting developing populations.1 Jordan affords a glaring example of the “debt trap” depicted by the authors: “Pressured by the International Monetary Fund, the Jordanian government raised the price of bread from 12 [US] cents [7p] to 26 cents per kg, and of more than 20 other basic food items.”2 In Uganda the equivalent of $3 (£1.86) a head is being spent annually on total health services, compared with $17 …
Abstract 2363: Effect Of Aspirin And Clopidogrel Resistance On Myonecrosis Following Percutaneous Coronary Intervention
Authors: Jacqueline Saw, Percy Jokhi, Andrew Starovoytov, Rebecca Fox, Graham Wong, Krishnan Ramanathan, Anthony Fung
Journal: Circulation (2007)

Background: The presence of aspirin and clopidogrel resistance is increasingly recognized. We seek to evaluate if patients with aspirin and/or clopidogrel resistance are predisposed to myonecrosis following percutaneous coronary interventions (PCI). Methods: This study is performed as a substudy of the Brief-PCI, which randomized 620 patients to 18hr or 2hr infusion of eptifibatide following PCI. To be eligible for our substudy, patients have to be pretreated with aspirin (≥5 days) and clopidogrel (either 75mg/d ≥5 days, or 300mg loading ≥6 hr), and have not received a glycoprotein IIb/IIIa inhibitor within the past 48hrs. Bedside point-of-care platelet aggregometry using Accumetrics VerifyNow™ Aspirin and Clopidogrel assays were performed at baseline prior to PCI. Patients with aspirin reaction unit (ARU) ≥550 were labeled as “aspirin resistant”. Patients with percent inhibition ≤20% on the VerifyNow™ Clopidogrel assays were labeled as “clopidogrel resistant”. Our primary endpoint is the prevalence of myonecrosis within 24hrs post-PCI (defined as elevation of Troponin I &gt;1μg/L when baseline levels are negative, or peak CK-MB &gt;3 times upper limit of normal and &gt;50% higher than baseline value). Results: We enrolled 203 patients, of which 181 had aspirin resistance assessed, 188 had clopidogrel resistance assessed, and 169 had both assessed. There were 5% ± 1.6% who were aspirin resistant, 29% ± 3.3% who were clopidogrel resistant, and 1% ± 0.8% who were resistant to both. The overall prevalence of myonecrosis within 24hrs of PCI was 9% ± 2%. Patients who were resistant to both aspirin and clopidogrel had a higher prevalence of myonecrosis compared to those who had normal response (50% vs. 8%, p=0.031). There was no difference in myonecrosis prevalence among aspirin resistant patients compared to those with normal aspirin response (11% vs. 8%, p=0.754), or among clopidogrel resistant patients compared to those with normal clopidogrel response (11% vs. 7%, p=0.390). The mean ARU and percent inhibition was not different between those with or without myonecrosis. Conclusion: Our data suggests that only a small proportion of patients were resistant to both aspirin and clopidogrel, and these patients may have a higher prevalence of myonecrosis following PCI.
Molecular Characterization of the Synergistic Effect on TFPI Inhibition By Fusion of Two Inhibitory Peptides
Authors: Michael Dockal, Rudolf Hartmann, Thomas Polakowski, Christoph Redl, Erwin Panholzer, Willibald Kammlander, Frank Osterkamp, Ulrich Reineke, Hans Brandstetter, Friedrich Scheiflinger
Journal: Blood (2014)
Contact Transmission of Rous Sarcoma
Authors: B. R. Burmester, A. K. Fontes, W. G. Walter
Journal: JNCI Journal of the National Cancer Institute (1960)

In 2 experiments involving a total of 820 inbred White Leghorns, the transmission of Rous sarcoma virus under conditions of direct bird-to-bird contact, which resulted in Rous sarcomas of the subcutis, the skeletal muscle, and the viscera, has been observed for the first time. Diluted virus applied to open feather follicles caused tumors, suggesting a mode of transmission; however, this may not be the only one, since almost half of the contact-positive chickens had tumors in the viscera only.
Denies conscientious objection
Authors: Eugene G Breen
Journal: BMJ (2008)

Serum and urine proteins were measured daily in 17 subjects undertaking a typical high altitude Himalayan trek. Marked changes occurred in a variety of serum proteins as a result of plasma volume alterations and 9stress9. There was only a sporadic increase in proteinuria. None of the changes was related to the development of acute mountain sickness.
Abstract 4042: Diabetes Mellitus and Systolic Dysfunction in End-Stage Renal Disease
Authors: Stuart Smalheiser, Fadi Hage, Angelo M De Mattos, Gilbert Zoghbi, Gilbert Perry, Ami E Iskandrian, Raed A Aqel
Journal: Circulation (2006)

Background Diabetes (DM) is the most common cause of end-stage renal disease (ESRD) in this country. It is also one of the strongest cardiovascular risk factors in the general population. However, ...