tbuckley/cabot-search huggingface dataset:
Antifungal-resistant <i>Trichophyton indotineae</i> - transmission warrants priority attention and international collaboration
Authors: Wenting Xie, Xue Kong, Weida Liu, Guanzhao Liang, Xiaofang Li
Journal: British Journal of Dermatology (2024)

Journal Article Accepted manuscript Antifungal-resistant Trichophyton indotineae - transmission warrants priority attention and international collaboration Get access Wenting Xie, Wenting Xie Department of Medical Mycology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China Search for other works by this author on: Oxford Academic Google Scholar Xue Kong, Xue Kong Department of Medical Mycology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, ChinaJiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, ChinaCAMS Collection Center of Pathogen Microorganisms-D (CAMS-CCPM-D), Nanjing, China Search for other works by this author on: Oxford Academic Google Scholar Weida Liu, Weida Liu Department of Medical Mycology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, ChinaJiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, ChinaCAMS Collection Center of Pathogen Microorganisms-D (CAMS-CCPM-D), Nanjing, ChinaCenter for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China Search for other works by this author on: Oxford Academic Google Scholar Guanzhao Liang, Guanzhao Liang Department of Medical Mycology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, ChinaJiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, ChinaCAMS Collection Center of Pathogen Microorganisms-D (CAMS-CCPM-D), Nanjing, China Correspondence: Guanzhao Liang Email:guanzhaoguan@126.com https://orcid.org/0000-0002-5330-8864 Search for other works by this author on: Oxford Academic Google Scholar Xiaofang Li Xiaofang Li Department of Medical Mycology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, ChinaJiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, ChinaCAMS Collection Center of Pathogen Microorganisms-D (CAMS-CCPM-D), Nanjing, China Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, ljae162, https://doi.org/10.1093/bjd/ljae162 Published: 15 April 2024 Article history Received: 10 April 2024 Accepted: 11 April 2024 Published: 15 April 2024
Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease
Authors: AnnJosette Ramirez, Christina A. Vyzas, Huaning Zhao, Kevin Eng, Karl Degenhardt, Sophie Astrof
Journal: Circulation Research (2024)

BACKGROUND: The resiliency of embryonic development to genetic and environmental perturbations has been long appreciated; however, little is known about the mechanisms underlying the robustness of developmental processes. Aberrations resulting in neonatal lethality are exemplified by congenital heart disease arising from defective morphogenesis of pharyngeal arch arteries (PAAs) and their derivatives. METHODS: Mouse genetics, lineage tracing, confocal microscopy, and quantitative image analyses were used to investigate mechanisms of PAA formation and repair. RESULTS: The second heart field (SHF) gives rise to the PAA endothelium. Here, we show that the number of SHF-derived endothelial cells (ECs) is regulated by VEGFR2 (vascular endothelial growth factor receptor 2) and Tbx1 . Remarkably, when the SHF-derived EC number is decreased, PAA development can be rescued by the compensatory endothelium. Blocking such compensatory response leads to embryonic demise. To determine the source of compensating ECs and mechanisms regulating their recruitment, we investigated 3-dimensional EC connectivity, EC fate, and gene expression. Our studies demonstrate that the expression of VEGFR2 by the SHF is required for the differentiation of SHF-derived cells into PAA ECs. The deletion of 1 VEGFR2 allele ( VEGFR2 SHF-HET ) reduces SHF contribution to the PAA endothelium, while the deletion of both alleles ( VEGFR2 SHF-KO ) abolishes it. The decrease in SHF-derived ECs in VEGFR2 SHF-HET and VEGFR2 SHF-KO embryos is complemented by the recruitment of ECs from the nearby veins. Compensatory ECs contribute to PAA derivatives, giving rise to the endothelium of the aortic arch and the ductus in VEGFR2 SHF-KO mutants. Blocking the compensatory response in VEGFR2 SHF-KO mutants results in embryonic lethality shortly after mid-gestation. The compensatory ECs are absent in Tbx1 +/- embryos, a model for 22q11 deletion syndrome, leading to unpredictable arch artery morphogenesis and congenital heart disease. Tbx1 regulates the recruitment of the compensatory endothelium in an SHF-non-cell-autonomous manner. CONCLUSIONS: Our studies uncover a novel buffering mechanism underlying the resiliency of PAA development and remodeling.
TCTAP C-071 Case Report: Sunlight After the Storm: Difficult Calcified Chronic Total Occlusion and Upfront Two Stent Strategy Bifurcation of LAD/D1 PCI
Authors: Richard Chay Shien Long, Jin Kiang Cheng, Jian Hao Sim, Hou Tee Lu, Azrina Abdul Kadir, Gurudevan Mahadevan, Wee Pang Ng, Wen Sheng Wong, Waye Young Lau
Journal: Journal of the American College of Cardiology (2024)
TCTAP C-171 What You See Is Not What You Imagine ; A Conundrum in Intervention
Authors: Vijayendran Rajalingam, Faizal Khan Bin Abdullah, Glendon Seng Lau, Thurston Erng, Asri Ranga, Kamaraj Selvaraj, Abd Kahar Abd Ghapar
Journal: Journal of the American College of Cardiology (2024)
TCTAP C-139 REGRET ME NOT: A Case of Stentablation Using Halfway Rotational Atherectomy of an Underexpanded and Undilatable Coronary Artery Stent in a Patient With a Recent ST-Elevation Myocardial Infarction
Authors: Allan Jake Cabanban Dela Cruz, Jhoanna Marcelo
Journal: Journal of the American College of Cardiology (2024)
TCTAP C-161 Negotiating the Tortuosities : PCI in a Female With Arteria Lusoria
Authors: Wickramasinghe Wasala Mudiyanselage Pasan Aminda B Abeysenevi, Mohamed Basheer Fasllur Rahuman, Nimali Fernando, Leonard Wanninayake, Chathurika Samarakoon Kempitiya B.C.T.A.N.W.M.R
Journal: Journal of the American College of Cardiology (2024)
TCTAP C-001 A Challenging Case Report: Non-ST Elevation Acute Coronary Syndrome With Critical Stenosis of Distal Left Main Bifurcation Caused by Eruptive Calcified Nodules
Authors: Piyoros Lertsanguansinchai, Anuruck Jeamanukoolkit, Piyanart Preeyanont, Tanyarat Aramsareewong, Worawut Tassanawiwat
Journal: Journal of the American College of Cardiology (2024)
TCTAP C-132 Longitudinal Stent Deformation During Radial Approach: Retrieval Through Radial Access Was Not an Option
Authors: Joel Herbet, Dafsah Arifa Juzar, Doni Firman, Amir Aziz Alkatiri, Arwin Saleh Mangkuanom, Nanda Iryuza
Journal: Journal of the American College of Cardiology (2024)
TCTAP A-043 Safety and Effectiveness of the 3-Dimensional Wiring Technique and Tip Detection Method With the IVUS for Femoropopliteal Complex Occlusive Disease
Authors: Akinori Sumiyoshi, Atsunori Okamura, Mutsumi Iwamoto, Satoshi Watanabe, Kota Tanaka, Tomohiro Yamasaki
Journal: Journal of the American College of Cardiology (2024)
TCTAP A-017 Ten-Year Clinical Outcomes According to Atherosclerotic Cardiovascular Disease Risk Score From AHA/ACC in Korean Patients With Significant Coronary Artery Spasm
Authors: Woo Jin Ahn, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Jinah Cha, Sujin Hyun, Jaeho Kang, Wonsang Chu, Soohyung Park, Cheol Ung Choi
Journal: Journal of the American College of Cardiology (2024)
TCTAP A-051 Feasibility and Accuracy of Three-Dimension Aortic Valve Annulus Planimetry on Cardiac CT Angiography: A New Full Automatic Deep Learning Method
Authors: Xinlei Wu, YiQiu Jiang, Ahmed Elkoumy, Xiaodong Wang, Osama Soliman, Xinmin Zhang, Daozhu Wu, Lianpin Wu
Journal: Journal of the American College of Cardiology (2024)
TCTAP C-198 Utilizing Self-Radiopaque Technique and Greater Aortic Curvature Guidance for On-Table Fenestration in Zone 0 Thoracic Endovascular Aortic Repair for Aortic Arch Aneurysm: A Case Report With Vietnam National Heart Institute Approach
Authors: Than Xuan Le, Tuan Minh Pham, Hung Manh Pham, Quang Ngoc Nguyen
Journal: Journal of the American College of Cardiology (2024)
TCTAP A-007 Diagnostic Accuracy of Platelet to Lymphocyte Ratio for Predicting No Slow Reflow After Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction: A Systematic Review and Meta-Analysis
Authors: Hendy Bhaskara Perdana Putra, Intan Dwistya Wiraguna, Noer Halimatus Syakdiyah, None Libriansyah, Richardus Rukma Juslim
Journal: Journal of the American College of Cardiology (2024)
TCTAP A-016 1 Year Clinical Outcomes of Patients Treated With DynamX Bioadaptor Drug Eluting Stent in Primary Percutaneous Coronary Intervention
Authors: Hee Hwa Ho, Cliff Li, Randal Jun Bang Low, Thet Khaing, Bharat Khialani, Jinhyun Lee, Deanna Zin Lin Khoo, Jason Kwok Kong Loh, Fahim Jafary
Journal: Journal of the American College of Cardiology (2024)
TCTAP A-010 Three Months Follow-up Patients After Acute Coronary Syndrome
Authors: Loc Vu, Dung Ho, Chinh Duc Nguyen, Thuan Huynh, Le Anh Do, Hieu Bui, Khang Phuc Nguyen, Tuong Diep, Quang Minh Mai, Thach Nguyen
Journal: Journal of the American College of Cardiology (2024)
TCTAP A-046 A Retrospective, Double-Centre Study on the Use of TEVAR in the Treatment of Traumatic Blunt Thoracic Aortic Injuries
Authors: Tze Gek Ho, Marc Chang Hao Chen, Enming Yong, Tan Wei Leong Glenn, Rhaen Chan Chong, Qiantai Hong, Malcolm Mak, Shaun Chan, Chuo Ren Leong, Dexter Yak Seng Chan
Journal: Journal of the American College of Cardiology (2024)
TCTAP C-029 A Challenging Case of Szabo Technique for Ostial Lesion in a Left Main Trifurcation
Authors: Khoo Song Weng Ryan, Houng Bang Liew, Chong Wei Loong, Neerusha Kaisbain, Chew Fui Lo, Pangeran Akbar Syah
Journal: Journal of the American College of Cardiology (2024)
Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis
Authors: Amy K. Hauck, Rashid Mehmood, Bryce J. Carpenter, Maxwell T. Frankfurter, Michael C. Tackenberg, Shin-ichi Inoue, Maria K. Krieg, Fathima N. Cassim Bawa, Mohit K. Midha, Delaine M. Zundell, Kirill Batmanov, Mitchell A. Lazar
Journal: Nature Metabolism (2024)
Correction to: Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors
Authors: Jooeun Bae, Teru Hideshima, Yu-Tzu Tai, Yan Song, Paul Richardson, Noopur Raje, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Leukemia (2024)
Unlocking the Role of Age-Related Changes to Fibroblasts in Pancreatic Cancer
Authors: Achinoam Isaacson, Debra Barki, Ruth Scherz-Shouval
Journal: Cancer Research (2024)

Abstract Pancreatic cancer prevalence increases with age, and disease prognosis is poorer in older individuals. The increased prevalence is driven, undoubtedly, by the multistep accumulation of oncogenic mutations in cancer cells with age. However, fibroblasts are major constituents and key players in pancreatic cancer, and they too undergo age-related changes that may contribute to disease severity. In this issue of Cancer Research, Zabransky and colleagues set out to dissect the effect of age-related changes in pancreatic fibroblasts on pancreatic ductal adenocarcinoma growth and metastasis. They discovered that aged fibroblasts secrete GDF-15, which in turn activates AKT signaling and accelerates tumor progression. These findings provide a mechanistic role for aged fibroblasts in pancreatic cancer, underpinning the importance of normal physiologic processes in tumor progression. See related article by Zabransky et al., p. 1221
Pushing the Frontiers of Cancer Research: Highlights from the Frontiers in Cancer Science Conference 2023
Authors: Yi Fei Lee, Leilei Chen, Valerie Chew, Edward Kai-Hua Chow, Lih-Wen Deng, Walter Hunziker, Ann Siew Gek Lee, Geraldine Leong, Joanne Ngeow, Shazib Pervaiz, Kanaga Sabapathy, Anders J. Skanderup, Raghav Sundar, Yvonne Tay, David M. Virshup, Sunny H. Wong, Vinay Tergaonkar, Wai Leong Tam
Journal: Cancer Research (2024)

Abstract The 15th annual Frontiers in Cancer Science (FCS) conference gathered scientific experts who shared the latest research converging upon several themes of cancer biology. These themes included the dysregulation of metabolism, cell death, and other signaling processes in cancer cells; using patient “omics” datasets and single-cell and spatial approaches to investigate heterogeneity, understand therapy resistance, and identify targets; innovative strategies for inhibiting tumors, including rational drug combinations and improved drug delivery mechanisms; and advances in models that can facilitate screening for cancer vulnerabilities and drug testing. We hope the insights from this meeting will stimulate further progress in the field.
Appendicitis Hospitalization Care Costs Among Patients With Delayed Diagnosis of Appendicitis
Authors: Dinushi A. Kulasekere, Regina Royan, Ying Shan, Ana M. Reyes, Arielle C. Thomas, Alexander L. Lundberg, Joe M. Feinglass, Anne M. Stey
Journal: JAMA Network Open (2024)

Importance Delayed appendicitis diagnosis is associated with worse outcomes. Appendicitis hospital care costs associated with delayed diagnosis are unknown. Objective To determine whether delayed appendicitis diagnosis was associated with increased appendicitis hospital care costs. Design, Setting, and Participants This cohort study used data from patients receiving an appendectomy aged 18 to 64 years in 5 states (Florida, Maryland, Massachusetts, New York, Wisconsin) that were captured in the Healthcare Cost and Utilization Project State Inpatient and Emergency Department databases for the years 2016 and 2017 with no additional follow-up. Data were analyzed January through April 2023. Exposures Delayed diagnosis was defined as a previous emergency department or inpatient hospital encounter with an abdominal diagnosis other than appendicitis, and no intervention 7 days prior to appendectomy encounter. Main Outcomes and Measures The main outcome was appendicitis hospital care costs. This was calculated from aggregated charges of encounters 7 days prior to appendectomy, the appendectomy encounter, and 30 days postoperatively. Cost-to-charge ratios were applied to charges to obtain costs, which were then adjusted for wage index, inflation to 2022 US dollar, and with extreme outliers winsorized. A multivariable Poisson regression estimated appendicitis hospital care costs associated with a delayed diagnosis while controlling for age, sex, race and ethnicity, insurance status, care discontinuity, income quartile, hospital size, teaching status, medical school affiliation, percentage of Black and Hispanic patient discharges, core-based statistical area, and state. Results There were 76 183 patients (38 939 female [51.1%]; 2192 Asian or Pacific Islander [2.9%], 14 132 Hispanic [18.5%], 8195 non-Hispanic Black [10.8%], 46 949 non-Hispanic White [61.6%]) underwent appendectomy, and 2045 (2.7%) had a delayed diagnosis. Delayed diagnosis patients had median (IQR) unadjusted cost of $11 099 ($6752-$17 740) compared with $9177 ($5575-$14 481) for nondelayed ( P &amp;amp;lt; .001). Patients with delayed diagnosis had 1.23 times (95% CI, 1.16-1.28 times) adjusted increased appendicitis hospital care costs. The mean marginal cost of delayed diagnosis was $2712 (95% CI, $2083-$3342). Even controlling for delayed diagnosis, non-Hispanic Black patients had 1.22 times (95% CI, 1.17-1.28 times) the adjusted increased appendicitis hospital care costs compared with non-Hispanic White patients. Conclusions and Relevance In this cohort study, delayed diagnosis of appendicitis was associated with increased hospital care costs.
Correction: MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma <i>In Situ</i>
Authors: Qianyu Guo, Vivian Z. Li, Jessica N. Nichol, Fan Huang, William Yang, Samuel E.J. Preston, Zahra Talat, Hanne Lefrère, Henry Yu, Guihua Zhang, Mark Basik, Christophe Gonçalves, Yao Zhan, Dany Plourde, Jie Su, Jose Torres, Maud Marques, Sara Al Habyan, Krikor Bijian, Frédéric Amant, Michael Wichter, Fariba Behbod, Luke McCaffrey, Moulay Alaoui-Jamali, Nadia V. Giannakopoulos, Muriel Brackstone, Lynne-Marie Postovit, Sonia V. del Rincón, William H. Miller
Journal: Cancer Research (2024)
Integrating Specialist and Primary Care in Chronic Disease Management
Authors: Yasaman Yazdani, Amit X. Garg, Merrick Zwarenstein
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia
Authors: Guangrong Qin, Jin Dai, Sylvia Chien, Timothy J. Martins, Brenda Loera, Quy H. Nguyen, Melanie L. Oakes, Bahar Tercan, Boris Aguilar, Lauren Hagen, Jeannine McCune, Richard Gelinas, Raymond J. Monnat, Ilya Shmulevich, Pamela S. Becker
Journal: Clinical Cancer Research (2024)

Abstract Purpose: The inherent genetic heterogeneity of acute myeloid leukemia (AML) has challenged the development of precise and effective therapies. The objective of this study was to elucidate the genomic basis of drug resistance or sensitivity, identify signatures for drug response prediction, and provide resources to the research community. Experimental Design: We performed targeted sequencing, high-throughput drug screening, and single-cell genomic profiling on leukemia cell samples derived from patients with AML. Statistical approaches and machine learning models were applied to identify signatures for drug response prediction. We also integrated large public datasets to understand the co-occurring mutation patterns and further investigated the mutation profiles in the single cells. The features revealed in the co-occurring or mutual exclusivity pattern were further subjected to machine learning models. Results: We detected genetic signatures associated with sensitivity or resistance to specific agents, and identified five co-occurring mutation groups. The application of single-cell genomic sequencing unveiled the co-occurrence of variants at the individual cell level, highlighting the presence of distinct subclones within patients with AML. Using the mutation pattern for drug response prediction demonstrates high accuracy in predicting sensitivity to some drug classes, such as MEK inhibitors for RAS-mutated leukemia. Conclusions: Our study highlights the importance of considering the gene mutation patterns for the prediction of drug response in AML. It provides a framework for categorizing patients with AML by mutations that enable drug sensitivity prediction.
Barcode lipids for absolute quantitation of liposomes in ocular tissues
Authors: Arto Merivaara, Jooseppi Puranen, Amir Sadeghi, Natalia Zashikhina, Lea Pirskanen, Tatu Lajunen, Tetsuya Terasaki, Seppo Auriola, Kati-Sisko Vellonen, Arto Urtti
Journal: Journal of Controlled Release (2024)

Lipid-based drug formulations are promising systems for improving delivery of drugs to ocular tissues, such as retina. To develop lipid-based systems further, an improved understanding of their pharmacokinetics is required, but high-quality in vivo experiments require a large number of animals, raising ethical and economic questions. In order to expedite in vivo kinetic testing of lipid-based systems, we propose a barcode approach that is based on barcoding liposomes with non-endogenous lipids. We developed and evaluated a liquid-chromatography-mass spectrometry method to quantify many liposomes simultaneously in aqueous humor, vitreous, and neural retina at higher than ±20% precision and accuracy. Furthermore, we showed in vivo suitability of the method in pharmacokinetic evaluation of six different liposomes after their simultaneous injection into the rat vitreal cavity. We calculated pharmacokinetic parameters in vitreous and aqueous humor, quantified liposome concentrations in the retina, and quantitated retinal distribution of the liposomes in the rats. Compared to individual injections of the liposome formulations, the barcode-based study design enabled reduction of animal numbers from 72 to 12. We believe that the proposed approach is reliable and will reduce and refine ocular pharmacokinetic experiments with liposomes and other lipid-based systems.
Correction: Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
Authors: Sang Jun Yoon, Joseph A. Combs, Aimee Falzone, Nicolas Prieto-Farigua, Samantha Caldwell, Hayley D. Ackerman, Elsa R. Flores, Gina M. DeNicola
Journal: Cancer Research (2024)
Incidental Finding of Spindle Cell Sarcoma on 68Ga-PSMA-11 PET/CT
Authors: Elena M. Anigati, Nghi C. Nguyen
Journal: Clinical Nuclear Medicine (2024)

Abstract A 78-year-old man underwent 68 Ga–prostate-specific membrane antigen-11 (PSMA-11) PET/CT for biochemical recurrence of prostate adenocarcinoma following a simple prostatectomy. The scan showed PSMA-avid local recurrence within the prostatectomy bed and a suspicious right internal iliac nodal metastasis. In addition, there was a mildly avid subcutaneous lesion in the right flank, which revealed high-grade spindle cell sarcoma at histopathology. This case represents a potential pitfall for PSMA-11 PET imaging. The presentation of mildly avid, atypical soft tissue lesions should warrant a biopsy to allow for proper diagnosis and treatment management.