tbuckley/cabot-search huggingface dataset:
Prospective observational study of a novel self-assembling peptide hemostatic gel for initial hemostasis in endoscopic sphincterotomy-related hemorrhage
Authors: Y. Ishida, T. Koga, N. Tsuchiya, T. Kitaguchi, K. Matsumoto, M. Fukuyama, N. Kuno, S. Funakoshi, S. Ashizuka, F. Hirai
Journal: Endoscopy (2024)

Aims Bleeding is recognized as one of the most commonly encountered adverse events associated with endoscopic sphincterotomy (EST). Although various techniques for endoscopic hemostasis have been reported, the treatment choice is left to the endoscopist. A novel self-assembling and fully synthetic hydrogel peptide (hemostatic gel) is currently developed as a hemostatic agent. This study aimed to evaluate the feasibility and effectiveness of the application of hemostatic gel to EST-related hemorrhage.
Evaluation of the clip anchorage technique using mucosal elevation and incision in prevention of esophageal stent migration
Authors: A. Darnaude, C. Gomercic, J. Boulant, G. Vanbiervliet
Journal: Endoscopy (2024)

Aims Migration remains a frequent complication following esophageal stent placement, particularly for covered material. Fixation of the stent to the mucosa using hemostatic clips has been shown to reduce the migration rate. In the hypothesis of a more efficient anchorage, the placement of a clip in a sub-mucosal situation has been described. The primary objective of the study was to evaluate the efficiency of this technique for preventing esophageal stent migration. Secondary objectives were to determine safety, predictive factors of migration and time to migration after stent placement.
Validation of a Virtual Reality Endoscopy Platform in Providing a Training Solution for Barrett’s Esophagus
Authors: T. El Menabawey, A. Sinclair, A. Geffen, G. Webster, D. Graham
Journal: Endoscopy (2024)

Aims Virtual reality (VR) offers an unrivalled immersive education opportunity to provide guaranteed pathology exposure, reproducible instruction and robust pathology recognition key performance indicators. We developed a novel VR platform to address the heterogenous and subjective nature of endoscopy education, which may contribute to the 11.3% published missed cancer rate of upper gastrointestinal endoscopy (EGD). Data demonstrates variability in the quality of endoscopic surveillance of Barrett's esophagus (BE) but accurate assessment is vital to detect early neoplasia and alter the grave prognosis of esophageal adenocarcinoma. We conducted a pilot validation study for a novel prototype VR endoscopy training environment for Barrett's esophagus.
Italian survey on biliary drainage approach in patients with post-surgical anatomy
Authors: A. Mauro, C. Binda, A. Fugazza, G. Vanella, V. G. Mirante, S. Mazza, I. Tarantino, C. Fabbri, A. Anderloni, G. I-Eus
Journal: Endoscopy (2024)

Aims Biliary drainage (BD) in patients with altered anatomy could be obtained endoscopically with different techniques or with a percutaneous BD. Every endoscopic technique could be challenging and not clearly superior over another. Percutaneous BD is usually easily available but has several issues on long-term management. Aim of this survey is to explore which is the standard BD approach in different tertiary and non-tertiary endoscopic centers in Italy.
Predictive factors of spontaneous biliary clearance and unnecessary ERCP in patients with choledocholithiasis
Authors: F. Pereira Correia, H. Coelho, M. Francisco, G. Alexandrino, J. C. Branco, J. Canena, L. Carvalho Lourenço, D. Horta
Journal: Endoscopy (2024)

Aims ERCP is associated with a non-negligible rate of adverse events (up to 10%) and should be reserved for procedures with therapeutic intent. Choledocholithiasis is the most common indication, however, if there is spontaneous migration of stones, ERCP becomes unnecessary. The incidence of this occurrence and the predictive factors are subject to discussion. The aim of this study was to evaluate predictive factors for spontaneous migration of CBD stones, in patients diagnosed with CBD stones on imaging and native papilla, which correlate with unnecessary ERCP.
A Simple Endoscopy Training and Assessment Box – Development and Validation
Authors: E. Glassey, R. Walmsley, S. Smith
Journal: Endoscopy (2024)

Aims Tools for teaching and practice of endoscopic skills outside of the clinical procedure have previously been in complex and expensive computer-based simulators. Assessment of endoscopy skills and competency is currently by achievement of Key Performance Indicators (KPIs) such as number of procedures attempted and caecal intubation rate as well as subjective procedural skills assessments. [1]
Panenteric Investigation and Surveillance with Double-Balloon Enteroscopy in Patients with Short Bowel Syndrome Treated with Teduglutide
Authors: A. Sorge, L. Scaramella, V. Smania, A. Costantino, G. E. Tontini, M. Vecchi, L. Elli
Journal: Endoscopy (2024)

Aims Short bowel syndrome (SBS) is the primary cause of chronic benign intestinal failure. Teduglutide (TED), a glucagon-like peptide-2 analog, is the only approved pharmacological therapy for SBS to reduce the need for parenteral nutrition and intravenous fluid support. [1] [2] Administered as a bowel trophic hormone, there are concerns regarding colorectal and small bowel cancer in patients undergoing TED treatment. Therefore, baseline and follow-up colonoscopy for cancer screening and surveillance are indicated. However, there is a lack of data on small bowel oncologic surveillance. This study aimed to assess the feasibility and efficacy of double-balloon enteroscopy (DBE) surveillance of SBS patients undergoing TED treatment.
Endoscopic mucosal resection of large nonpedunculated colorectal polyps: Recurrence rates and predictors
Authors: S. Ramos Lopes, I. Costa Santos, M. Teixeira, C. Sequeira, C. Teixeira, J. Mangualde, E. Gamito, A. L. Alves
Journal: Endoscopy (2024)

Aims Recurrence rates following endoscopic mucosal resection (EMR) range from 12 to 24%, with larger lesions harboring a higher risk for recurrence. We aimed to assess the recurrence rate after EMR of large nonpedunculated colorectal polyps and identify potential predictors of recurrence.
Transjugular Intrahepatic Portosystemic Shunt improves rebleeding and survival in gastric variceal hemorrhage
Authors: F. Sanoubara, M. Kimmann, J. Gödiker, S. N. Reinartz Groba, F. Weppelmann, J. Chang, C. Jansen, C. Meyer, M. Köhler, W. Laleman, J. Trebicka, J. A. Meier, M. Praktiknjo
Journal: Endoscopy (2024)

Aims Variceal hemorrhage (VH) is a life-threatening complication of liver cirrhosis. Transjugular intrahepatic portosystemic shunt (TIPS) is so far the most efficient treatment for preventing rebleeding. TIPS also improves survival in selected patients populations with VH. However, the majority of studies conducted so far have focused on esophageal VH. The aim of this study is the assessment of the efficacy of TIPS in gastric VH
Evaluation Of P53 And Wnt Pathway In Colorectal Tissues Of Patients With Inflmammatory Bowel Disease And Adenomatous Polyps
Authors: A. Juniku Shkololli
Journal: Endoscopy (2024)

Aims The purpose of this study is to novel routine screening and diagnostic methods (Endoscopic biopsy and immunohistochemistry) and find reliable molecular markers for early diagnosis of colorectal cancer among high-risk patients – with inflammatory bowel disease or colorectal polyps. Mutations of the tumor suppressor gene P53 is an early event of ulcerative colitis-associated carcinogenesis, in which the mutation of the P53 gene is preceded by the loss of heterozygosity in the development of colon cancer. Inactivation of the APC tumour suppressor results in the constitutive activation of canonical WNT pathway transcriptional effector ß-catenin, along with induction of WNT feedback inhibitors. Hypothesis statement: beta catenin and p53 could be established as markers for dysplasia screeniing and early colorectal cancer detection.
Feasibility of the Mantis Clip for Mucosal Defect Closure after Colorectal Endoscopic Submucosal Dissection
Authors: M. Tanabe, D. Shiomi, K. Kunita, N. Kawamata, H. Nakamura, M. Kure, A. Toshimori, Y. Shimamura, N. Uragami, H. Inoue
Journal: Endoscopy (2024)

Aims Mucosal defect closure after colorectal endoscopic submucosal dissection (ESD) may decrease the incidence of delayed adverse events (AEs) such as bleeding, perforation. This study aimed to assess the efficacy of the Mantis Clip (Boston Scientific) in mucosal defect closure after colorectal endoscopic submucosal dissection (ESD), potentially reducing delayed adverse events such as bleeding and perforation.
Pan-enteric mucosal inflammation in Crohn&amp;apos;s disease patients treated with vedolizumab assessed by capsule endoscopy– interim results of a prospective observational study
Authors: O. Ukashi, A. Lahat, B. Ungar, H. Levy, P. Eidler, S. Ben-Horin, R. Eliakim, U. Kopylov
Journal: Endoscopy (2024)

Aims Mucosal healing (MH) is a paramount treatment goal in Crohn's disease (CD). The vast majority of data pertains to MH in the colon and terminal ileum. Data regarding pan-enteric MH (P-MH) among patients with active CD who were treated with vedolizumab (VDZ) are lacking. We aimed to evaluate the efficacy of VDZ for achieving P-MH using pan-enteric capsule endoscopy (CE).
Impact of advanced energy platform on health economics: a pilot value-based procurement explorative analysis
Authors: S. Zeidan, A. Reynolds, M. Abbas, P. B. Adolfo, Z. Tsiamoulos
Journal: Endoscopy (2024)

Aims When indicated Speedboat -Endoscopic Submucosal Dissection/S-ESD is a novel alternative endoscopic procedure that uses innovative modalities to safely and effectively remove pre-cancerous and suspected cancerous complex lesions in the colon, in turn removing the need for surgical interventions and the associated complications, bed stays, resources and costs to the Trust/hospital
Outcomes Of Colorectal Endoscopic Submucosal Dissection According To The Size Of Colorectal Neoplasm: A HASID Multicenter Study
Authors: D. H. Kim, B. C. Jin, H. H. Oh, H. Y. Song, S. J. Kim, D. S. Myung, H. S. Kim, S. W. Kim, J. Lee, Y. E. Joo, G. S. Seo
Journal: Endoscopy (2024)

Aims Endoscopic submucosal dissection (ESD) is a valuable technique for treating early colorectal neoplasms. However, there is insufficient data available concerning the treatment outcomes in relation to the size of colorectal neoplasms.
Value of the green sign and chicken skin aspects to predict malignancy in colorectal neoplasia in a prospective characterization study
Authors: P. Lafeuille, J. Rivory, A. Lupu, R. Florian, J. Jacques, T. Wallenhorst, A. Bartoli, S. Torti, T. Fenouil, M. Frederic, F. Subtil, M. Pioche
Journal: Endoscopy (2024)

Aims Accurate endoscopic characterization of colorectal lesions is essential for predicting histopathological characterization but is difficult even for experts [1]. Simple criteria could help endoscopists detect and predict malignancy. This study aimed to assess the value of green sign [2] and chicken skin [3] aspects in predicting colorectal neoplasia malignancy.
Combined use of antegrade double-balloon enteroscopy and electrohydraulic lithotripsy for bezoar retrieval in a patient with Crohn’s Disease
Authors: L. Scaramella, F. Benedicenti, T. Pessarelli, G. E. Tontini, N. Nandi, M. Vecchi, L. Elli
Journal: Endoscopy (2024)

Abstract Text We present a case of a 54-years-old male with structuring ileo-colonic Crohn's disease. A magnetic resonance enterography showed a mid-ileal dilation with a 3x1.5cm bezoar; removal through antegrade double-balloon enteroscopy(DBE) was scheduled. It was reached at an estimated depth of 300cm, close to a partially ulcerated stricture. Electrohydraulic lithotripsy(EHL) was performed to reduce its size, shock waves were transmitted in 0.9%NaCl solution. After a quite rapid exhaustion of the EHL probe, due to kinking in DBE loops, the bezoar was only partially fractured. It was then retrieved using a retrieval net; pylorus and cardia passages were achieved with a single intravenous administration of glucagon (1 mg). No adverse events occurred, and the patient was discharged the day after. DBE is effective in several small bowel condition, resulting in a surgery-sparing technique.
EUS-guided biliary drainage via cholecystogastrostomy followed by a rendezvous procedure to stent a difficult malignant biliary stricture
Authors: M. Lajin, N. Khan
Journal: Endoscopy (2024)

Abstract Text A 62-year-old male presented with jaundice. Abdominal CT revealed a pancreatic mass resulting in biliary obstruction. EUS/FNB confirmed locally advanced pancreatic cancer. ERCP failed to cannulate the bile duct. EUS-guided cholecystogastrostomy was performed using a 1 cm LAMS. His LFTs normalized. Six weeks later, a pediatric endoscope was advanced inside the gallbladder. A wire was navigated through the cystic duct to the bile duct. An ERCP catheter was positioned above the stricture and helped the wire traverse the biliary stricture. The endoscope was removed keeping the wire in place. A duodenoscope was positioned facing the papilla en face. Cannulation on the side of the rendezvous wire was successful. The stricture was stented with a fully covered self-expendable metal stent.
Two-handed vs four-handed colonoscopy in terms of quality
Authors: F. J. Puchol Rodrigo, C. Mangas Sanjuán, F. Ruiz Gómez, J. Martinez Sempere, S. Baile-Maxía, P. López-Guillén, O. Belén Galipienso, N. Sala-Miquel, J. R. Aparicio, L. Compañy Catalá
Journal: Endoscopy (2024)

Aims We want to compare colonoscopy in our hospital with a four-handed technique (i.e., with nursing assistance) to a two-handed technique (i.e., with the colonoscope manipulated only by the endoscopist), regarding three quality criteria: cecal intubation rate (CIR), adenoma detection rate (ADR) and complication rate (CR).
Reliability Concerns: Can AI Interpret Nuanced Medical and Ethical Scenarios in the Field of Gastroenterology
Authors: R. M. Ram mohan, M. Joy, S. G. Magam, D. Natt, S. R. Magam, L. Pannikodu, J. Desai, P. Mustacchia
Journal: Endoscopy (2024)

Aims AI tools like ChatGPT and Google Bard are gaining traction in healthcare, notably gastroenterology, offering benefits such as vast data knowledge, swift responses, and easy access. However, their reliability in medical and ethical decision-making is uncertain. They provide information effectively but cannot fully emulate human medical professionals' nuanced understanding and empathy. Especially in ethical decisions, which demand comprehension of personal and contextual factors, these AI tools should serve as adjuncts, not replacements, to expert human judgment.
On the way to standardisation of EUS-guided hepaticogastrostomy
Authors: B. Martínez-Moreno, G. López-Roldán, L. Guilabert, J. Martinez Sempere, C. Mangas, L. Company, F. Ruiz, J. R. Aparicio
Journal: Endoscopy (2024)

Aims Fistula dilation is one of the key steps when performing EUS-guided hepaticogastrostomy (EUS-HG). Knowing whether there are differences between the existing tools used in EUS-HG dilation may reduce the complexity and adverse events (AEs) associated with this technique.
Comparison of disposable digital single-operator cholangioscopy versus direct peroral cholangioscopy for the management of intraductal superficial lesions of the bile duct
Authors: I. S. Shin, J. H. Moon, Y. N. Lee, J. H. Myeong, J. W. Park, J. W. Park, T. H. Lee, J. K. Yang, Y. D. Cho, S. H. Park
Journal: Endoscopy (2024)

Aims Disposable digital single-operator cholangioscopy (D-SOC) and direct peroral cholangioscopy using an ultra-slim endoscope (D-POC) are both established modalities for the diagnosis and treatment of biliary diseases. We aimed to evaluate and compare the usefulness of the D-SOC and D-POC for the management of intraductal superficial lesions of the bile duct (ISL-Bs).
Virtual reality as an alternative to anaesthesia during colonoscopy: a prospective equivalent study in Nancy
Authors: M. Schaefer, E. neuville, C. Baumann, A. Luc, M. Francois, S. Daude, B. Caron, M. Vinson, M. Simonnot, M. Bensenane, J. B. Chevaux
Journal: Endoscopy (2024)

Aims Colonoscopy is an invasive procedure that may cause patients pain and discomfort. Moderate to deep sedation is mostly used to ensure quality of the procedure and patients comfort. However, sedation is associated with some risks and side effects. Virtual reality (VR) offers immersive and three-dimensional experiences that distract patients' attention. This prospective comparative open-label study aims to determine if colonoscopies with complete sedation or with VR are equivalent.
Outcomes of different treatment approaches after R0 endoscopic resection of high-risk T1 esophageal adenocarcinoma: An international multicentre retrospective cohort study
Authors: M. W. Chan, R. Haidry, N. Benjamin, M. Di Pietro, A. V. Hadjinicolaou, M. Barret, P. Doumbe-Mandengue, S. Seewald, R. Bisschops, P. Nafteux, M. J. Bourke, S. Gupta, P. Mundre, A. Lemmers, C. Vuckovic, O. Pech, P. Leclercq, E. Coron, S. Meijer, J. Bergman, R. Pouw
Journal: Endoscopy (2024)

Aims Optimal management after R0 endoscopic resection (ER) of T1 esophageal adenocarcinoma (EAC) with≥1 high-risk histological feature (i.e. submucosal invasion, a/o poor differentiation, a/o lympho-vascular invasion) is subject to debate, given conflicting reports on risk of lymph node metastases (N+). This cohort study (NCT04818476) aimed to assess outcomes following R0 ER for high-risk T1 EAC.
Doppler probe and unroofing in the management of gastrointestinal subepithelial lesions
Authors: M. Omae, W. Naining, H. Maltzman, F. Baldaque-Silva
Journal: Endoscopy (2024)

Aims Subepithelial lesions (SELs) are common and their diagnosis is usually not possible through regular endoscopy and biopsies. As deep biopsies may be associated with severe bleeding, patients are usually referred for endoscopic ultrasound (EUS). EUS is performed to characterize the lesion, its size, structure, location in the wall and vascularity. EUS-fine needle aspiration or biopsy (FNA/FNB) may enable sampling and diagnosis. However, EUS is highly operator dependent, expensive and is only performed in specialized centers. EUS investigations of SEL represent a significant burden for EUS operations. This causes long waiting lists for EUS and increases patient's anxiety. Additionally, diagnostic accuracy of EUS is usually dependent on tissue sampling, being poor in small or polypoid lesions. There is the need for another approach for the assessment of SELs. The ideal solution should be safe, easy to perform, cheaper, non-highly operator dependent and available at first endoscopy (at any center). The doppler endoscopic prove (DEP) can be inserted through a conventional endoscope and enables assessment of vascularity beneath the mucosa in 3 different depth cathegories (superficial/middle/deep). Some studies had proven its efficacy in the management of peptic ulcer.
Application of a new Endoscopic Suturing Device for removal of gastric SELS
Authors: P. Deprez, M. Do Vale
Journal: Endoscopy (2024)

Abstract Text Achieving surgical-type sutures during invasive endoscopic procedures (dissection, full-thickness, NOTES) has always been a goal, even a dream, of interventional endoscopists. In this video, we describe a new endoscopic suturing device that can be used to close parietal defects (mucosal and muscular) in different gastric positions. It consists of a disposable Needle Holder and auto-locking surgical thread. The 3 cases correspond to full-thickness resections of SELs or GISTs at gastric antral, corporeal, and cardial sites. After resection using hybrid techniques (excavation, dissection), the parietal defect was closed with the help of SutuArt (Olympus). The new hand suture system appears to be effective in closure of gastric mucosal and muscular defects, and could find other endoscopic digestive applications.
Efficacy and safety of the cryoballoon 180 ablation system for the treatment of dysplastic Barrett’s esophagus: preliminary results from a prospective Dutch multicenter study
Authors: K. Munters, C. N. Frederiks, A. Overwater, S. N. Van Munster, R. Pouw, J. Bergman, B. L. Weusten
Journal: Endoscopy (2024)

Aims Cryoballoon ablation is a relatively new method which can be used for the eradication of dysplastic Barrett's esophagus (BE). While the focal cryoballoon ablation system has shown promising results for limited BE, the cryoballoon180 ablation (CBAS180) system is developed to ablate the esophagus semi-circumferential over 3cm length which enables treatment of larger BE segments. Although a prior first-in-human study demonstrated that CBAS180 treatment was feasible and effective, there was also room to optimize the safety profile by reducing the dose. Therefore, in the current study, we investigated a lower dose of the CBAS180 system in patients with dysplastic BE.
Novel Approach for weight reduction in post Roux -en-Y Gastric Bypass (RYGB) with weight regain- A combination of Bariatric Anastomotic Reduction System(BARS) with Endoscopic sleeve gastroplasty (ESG) of residual gastric pouch
Authors: P. Inavolu, R. Kalapala, N. Jagtap, S. K. Ch, S. Darisetty, N. R. Duvvur
Journal: Endoscopy (2024)

Abstract Text Significant weight regain (WR) with relapse of obesity-related complications has become relevant issue in one-third of the patients after RYGB.The underlying causes for WR are the anatomic factors, dilation of the GJ (>20 m) and pouch dilation have been shown to be a major factors (1). Endoscopic reduction of the anastomotic site size between the gastric reservoir and the jejunum is a possible option to slow down bypass of food and endoscopic resizing of the residual gastric pouch would be an option to regain the restrictive effect of gastric bypass [1] [2] [3].
Endoscopic Mucosal Resection versus Endoscopic Submucosal Dissection for Barrett&amp;apos;s Neoplasia: Clinical Outcomes at a Canadian Tertiary Referral Center
Authors: K. Khalaf, Y. Fujiyoshi, D. Tham, M.R. A. Fujiyoshi, N. Calo, J. Mosko, G. May, C. Teshima
Journal: Endoscopy (2024)

Aims Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are established techniques for endoscopic resection of Barrett's neoplasia, but consensus is lacking for which offers superior outcomes. This study compares the outcomes of EMR and ESD at a Canadian tertiary Barrett's referral center.
Clinical usefulness of AI-assisted small bowel localization and lesion detection in capsule endoscopy
Authors: Y. J. Yang, B. J. Cho, H. J. Jang
Journal: Endoscopy (2024)

Aims Although various AI models have been developed to detect small bowel (SB) abnormalities in capsule endoscopy (CE), AI models that simultaneously enable the localization of SB and detection of SB abnormalities were rarely developed. This study aimed to develop an AI model that automatically discriminated SB from stomach and colon, diagnosed multiple abnormalities in CE, and compared its performance to that of experienced endoscopists.
Ablate, stent and repeat: Feasibility, clinical success and safety profile of intraductal radiofrequency ablation in the management of inoperable perihilar cholangiocarcinoma patients – interim analysis of the COMBO-RFA randomized clinical trial
Authors: M. Birligea, C. Diaconu, A. Voiosu, A. Bengus, E. Dumea, C. Popp, B. Galateanu, A. Hudita, I. Pantelimon, T. Draghici, F. Rouhani, O. Ginghina, R. B. Mateescu, T. Voiosu
Journal: Endoscopy (2024)

Aims Intraductal radiofrequency ablation (RFA) has been proposed as a useful adjunctive therapeutic method for patients with inoperable perihilar cholangiocarcinoma (pCCA). There is limited data regarding the benefits of RFA and there is currently no standard protocol for RFA-based endoscopic treatment, including timing, number of applications and type of stenting required in this setting. We aimed to evaluate the feasibility, efficacy and safety of a novel RFA-based endoscopic palliation protocol.