tbuckley/cabot-search huggingface dataset:
Design of randomized controlled trials to estimate cancer-mortality reductions from multicancer detection screening
Authors: Ping Hu, Philip C Prorok, Hormuzd A Katki
Journal: JNCI Journal of the National Cancer Institute (2024)

Determining whether screening with multicancer detection (MCD) tests saves lives requires randomized controlled trials (RCTs). To inform RCT design, we estimated cancer-mortality outcomes from hypothetical MCD RCTs.
Deciphering the Mechanistic Impact of Acupuncture on the Neurovascular Unit in Acute Ischemic Stroke: Insights From Basic Research in a Narrative Review
Authors: Hailun Jiang, Chao Zhang, Mengxuan Lin, Yu Yin, Shizhe Deng, Wei Liu, Bifang Zhuo, Guang Tian, Yuzheng Du, Zhihong Meng
Journal: Ageing Research Reviews (2024)
Prediction of hepatocellular carcinoma and liver-related events in anti-HDV positive individuals
Authors: Lesley A Patmore, Michelle Spaan, K Agarwal, Özgür M Koc, Hans Blokzijl, Samantha Brouwer, Hanneke van Soest, Astrid G W van Hulzen, Harry L A Janssen, A J Jolanda Lammers, Louis Jansen, Mark Claassen, Robert A de Man, R Bart Takkenberg, Remco van Dijk, Dirk Posthouwer, Jurriën G P Reijnders, Ivana Carey, Milan J Sonneveld
Journal: Clinical Gastroenterology and Hepatology (2024)

Chronic hepatitis D (CHD) is the most severe form of chronic viral hepatitis, with a high risk of developing hepatocellular carcinoma (HCC) and liver-related mortality. Risk stratification is needed to guide HCC surveillance strategies and to prioritize treatment with antiviral agents.
MX2 forms nucleoporin-comprising cytoplasmic biomolecular condensates that lure viral capsids
Authors: George D. Moschonas, Louis Delhaye, Robin Cooreman, Franziska Hüsers, Anayat Bhat, Zoe Stylianidou, Elien De Bousser, Laure De Pryck, Hanna Grzesik, Delphine De Sutter, Eef Parthoens, Anne-Sophie De Smet, Aleksandra Maciejczuk, Saskia Lippens, Nico Callewaert, Linos Vandekerckhove, Zeger Debyser, Beate Sodeik, Sven Eyckerman, Xavier Saelens
Journal: Cell Host & Microbe (2024)

Human myxovirus resistance 2 (MX2) can restrict HIV-1 and herpesviruses at a post-entry step through a process requiring an interaction between MX2 and the viral capsids. The involvement of other host cell factors, however, remains poorly understood. Here, we mapped the proximity interactome of MX2, revealing strong enrichment of phenylalanine-glycine (FG)-rich proteins related to the nuclear pore complex as well as proteins that are part of cytoplasmic ribonucleoprotein granules. MX2 interacted with these proteins to form multiprotein cytoplasmic biomolecular condensates that were essential for its anti-HIV-1 and anti-herpes simplex virus 1 (HSV-1) activity. MX2 condensate formation required the disordered N-terminal region and MX2 dimerization. Incoming HIV-1 and HSV-1 capsids associated with MX2 at these dynamic cytoplasmic biomolecular condensates, preventing nuclear entry of their viral genomes. Thus, MX2 forms cytoplasmic condensates that likely act as nuclear pore decoys, trapping capsids and inducing premature viral genome release to interfere with nuclear targeting of HIV-1 and HSV-1.
The Interplay of Persistent Organic Pollutants and Mediterranean Diet in Association With the Risk of Gestational Diabetes Mellitus
Authors: Guoqi Yu, Wei Wei Pang, Jiaxi Yang, Claire Guivarch, Jagteshwar Grewal, Zhen Chen, Cuilin Zhang
Journal: Diabetes Care (2024)

Certain foods characterizing the alternate Mediterranean diet (aMED) are high in persistent organic pollutants (POPs), which are related to greater gestational diabetes mellitus (GDM) risk. We examined the associations of combined aMED and POP exposure with GDM.
Systematic review and meta-analysis of standalone digital interventions for cognitive symptoms in people without dementia
Authors: Veronica Cabreira, Tim Wilkinson, Lisbeth Frostholm, Jon Stone, Alan Carson
Journal: npj Digital Medicine (2024)

Abstract Cognitive symptoms are prevalent across neuropsychiatric disorders, increase distress and impair quality of life. Self-guided digital interventions offer accessibility, scalability, and may overcome the research-to-practice treatment gap. Seventy-six trials with 5214 participants were identified. A random-effects meta-analysis investigated the effects of all digital self-guided interventions, compared to controls, at post-treatment. We found a small-to-moderate positive pooled effect on cognition ( k = 71; g = −0.51, 95%CI −0.64 to −0.37; p &lt; 0.00001) and mental health ( k = 30; g = −0.41, 95%CI −0.60 to −0.22; p &lt; 0.0001). Positive treatment effects on fatigue ( k = 8; g = −0.27, 95%CI −0.53 to −0.02; p = 0.03) and quality of life ( k = 22; g = −0.17, 95%CI −0.34 to −0.00; p = 0.04) were only marginally significant. No significant benefit was found for performance on activities of daily living. Results were independent of control groups, treatment duration, risk of bias and delivery format. Self-guided digital transdiagnostic interventions may benefit at least a subset of patients in the short run, yet their impact on non-cognitive outcomes remains uncertain.
Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma
Authors: Varsha Thoppey Manoharan, Aly Abdelkareem, Gurveer Gill, Samuel Brown, Aaron Gillmor, Courtney Hall, Heewon Seo, Kiran Narta, Sean Grewal, Ngoc Ha Dang, Bo Young Ahn, Kata Osz, Xueqing Lun, Laura Mah, Franz Zemp, Douglas Mahoney, Donna L. Senger, Jennifer A. Chan, A. Sorana Morrissy
Journal: Genome biology (2024)

Diffuse invasion of glioblastoma cells through normal brain tissue is a key contributor to tumor aggressiveness, resistance to conventional therapies, and dismal prognosis in patients. A deeper understanding of how components of the tumor microenvironment (TME) contribute to overall tumor organization and to programs of invasion may reveal opportunities for improved therapeutic strategies.
Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation
Authors: Gerry A. Shipman, Reinnier Padilla, Cynthia Horth, Bo Hu, Eric Bareke, Francisca N. Vitorino, Joanna M. Gongora, Benjamin A. Garcia, Chao Lu, Jacek Majewski
Journal: Genome biology (2024)

Methylation of histone 3 lysine 36 (H3K36me) has emerged as an essential epigenetic component for the faithful regulation of gene expression. Despite its importance in development and disease, how the molecular agents collectively shape the H3K36me landscape is unclear. We use mouse mesenchymal stem cells to perturb the H3K36me methyltransferases (K36MTs) and infer the activities of the five most prominent enzymes: SETD2, NSD1, NSD2, NSD3, and ASH1L. We find that H3K36me2 is the most abundant of the three methylation states and is predominantly deposited at intergenic regions by NSD1, and partly by NSD2. In contrast, H3K36me1/3 are most abundant within exons and are positively correlated with gene expression. We demonstrate that while SETD2 deposits most H3K36me3, it may also deposit H3K36me2 within transcribed genes. Additionally, loss of SETD2 results in an increase of exonic H3K36me1, suggesting other (K36MTs) prime gene bodies with lower methylation states ahead of transcription. While NSD1/2 establish broad intergenic H3K36me2 domains, NSD3 deposits H3K36me2 peaks on active promoters and enhancers. Meanwhile, the activity of ASH1L is restricted to the regulatory elements of developmentally relevant genes, and our analyses implicate PBX2 as a potential recruitment factor. Within genes, SETD2 primarily deposits H3K36me3, while the other K36MTs deposit H3K36me1/2 independently of SETD2 activity. For the deposition of H3K36me1/2, we find a hierarchy of K36MT activities where NSD1 > NSD2 > NSD3 > ASH1L. While NSD1 and NSD2 are responsible for most genome-wide propagation of H3K36me2, the activities of NSD3 and ASH1L are confined to active regulatory elements.
Improved detection of methylation in ancient DNA
Authors: Susanna Sawyer, Pere Gelabert, Benjamin Yakir, Alejandro Llanos-Lizcano, Alessandra Sperduti, Luca Bondioli, Olivia Cheronet, Christine Neugebauer-Maresch, Maria Teschler-Nicola, Mario Novak, Ildikó Pap, Ildikó Szikossy, Tamás Hajdu, Vyacheslav Moiseyev, Andrey Gromov, Gunita Zariņa, Eran Meshorer, Liran Carmel, Ron Pinhasi
Journal: Genome biology (2024)

Abstract Reconstructing premortem DNA methylation levels in ancient DNA has led to breakthrough studies such as the prediction of anatomical features of the Denisovan. These studies rely on computationally inferring methylation levels from damage signals in naturally deaminated cytosines, which requires expensive high-coverage genomes. Here, we test two methods for direct methylation measurement developed for modern DNA based on either bisulfite or enzymatic methylation treatments. Bisulfite treatment shows the least reduction in DNA yields as well as the least biases during methylation conversion, demonstrating that this method can be successfully applied to ancient DNA.
A partial loss-of-function variant (Ile191Val) of the TAS1R2 glucose receptor is associated with enhanced responses to exercise training in older adults with obesity: A translational study
Authors: Joan Serrano, Saki Kondo, Grace M Link, Ian S Brown, Richard E Pratley, Kedryn K Baskin, Bret H Goodpaster, Paul M Coen, George A Kyriazis
Journal: Metabolism (2024)
Human DNA polymerase ε is a source of C&gt;T mutations at CpG dinucleotides
Authors: Marketa Tomkova, Michael John McClellan, Gilles Crevel, Akbar Muhammed Shahid, Nandini Mozumdar, Jakub Tomek, Emelie Shepherd, Sue Cotterill, Benjamin Schuster-Böckler, Skirmantas Kriaucionis
Journal: Nature Genetics (2024)

C-to-T transitions in CpG dinucleotides are the most prevalent mutations in human cancers and genetic diseases. These mutations have been attributed to deamination of 5-methylcytosine (5mC), an epigenetic modification found on CpGs. We recently linked CpG>TpG mutations to replication and hypothesized that errors introduced by polymerase ε (Pol ε) may represent an alternative source of mutations. Here we present a new method called polymerase error rate sequencing (PER-seq) to measure the error spectrum of DNA polymerases in isolation. We find that the most common human cancer-associated Pol ε mutant (P286R) produces an excess of CpG>TpG errors, phenocopying the mutation spectrum of tumors carrying this mutation and deficiencies in mismatch repair. Notably, we also discover that wild-type Pol ε has a sevenfold higher error rate when replicating 5mCpG compared to C in other contexts. Together, our results from PER-seq and human cancers demonstrate that replication errors are a major contributor to CpG>TpG mutagenesis in replicating cells, fundamentally changing our understanding of this important disease-causing mutational mechanism.
Multifunctional Sericin-Based Biomineralized Nanoplatforms with Immunomodulatory and Angio/Osteo-genic Activity for Accelerated Bone Regeneration in Periodontitis
Authors: Piaoye Ming, Bojiang Li, Qiumei Li, Lingling Yuan, Xueyu Jiang, Yunfei Liu, Rui Cai, Peirong Zhou, Xiaorong Lan, Gang Tao, Jingang Xiao
Journal: Biomaterials (2024)
Alleviation of colitis by honeysuckle MIR2911 via direct regulation of gut microbiota
Authors: Weili Li, Jiaqi Ding, Silin Chen, Jiangning Chen, Chen Wang, Jiaxin Li, Huanhuan Shi, Xiaojiao Yin, Jin Wang, Jiachen Liu, Huichen Song, Zhen Zhou, Xiaohong Jiang, Wantong Jiang, Yufei Jiang, Mingxi Cao, Botao Li, Jing Li, Liang Li, Yujing Zhang
Journal: Journal of Controlled Release (2024)
The brain–eye connection: More than just action potentials
Authors: James Walsh
Journal: The Journal of Experimental Medicine (2024)

In this issue of the Journal of Experimental Medicine, Cao et al. (https://doi.org/10.1084/jem.20240386) demonstrate that the connection between the eye and the brain goes beyond the impulses carried by the optic nerve and that in Alzheimer’s disease (AD), the influx of toxic Aβ from the brain to the retina underlies AD-induced retinal degeneration.
HoloPatch: Improving intracardiac patch fit through holographically modelled templates
Authors: Matthias Lippert, Gabriella d’ Albenzio, Kathrine Rydén Suther, Karl-Andreas Dumont, Rafael Palomar, Hans Henrik Odland, Ole Jakob Elle, Bjørn Bendz, Henrik Brun
Journal:  (2024)

Abstract Aims Structural heart defects, including congenital ventricular septal defect closure or intracardiac rerouting, frequently require surgical reconstruction using hand-cut patch materials. Digitally modelled patch templates may improve patch fit and reduce outflow tract obstruction, residual defect risk, and conduction system damage. In this study, we benchmarked mixed-reality and a desktop application against a digitalized model of a real implanted patch. Methods and results Ten patients scheduled for the repair of various defects consented to prospective inclusion in the study. After surgery, a digital model of the implanted patch was created from the residual material. Five clinical experts created 10 digital patches, 1 per patient, both in mixed-reality and desktop application, for comparison with the reference measurements, including the digitalized model of the real patch used during the surgery. Subjective residual shunt risk prediction was performed using both modalities. Digital patches created in mixed-reality closely matched the surgical material, whereas those created using desktop applications were significantly smaller. Different evaluators showed varying preferences for the application of the residual shunt risk and area. Conclusion Digitally created patches can assist surgeons in preoperatively sizing of patch implants, potentially reducing post-operative complications.
No Impact of Concomitant Medications on Efficacy and Safety of Biologics and Small Molecules for Ulcerative Colitis
Authors: Dhruv Ahuja, Guangyong Zou, Virginia Solitano, Gaurav Syal, Han Hee Lee, Christopher Ma, Vipul Jairath, Siddharth Singh
Journal: Clinical Gastroenterology and Hepatology (2024)
Harm-to-benefit ratio of fecal immunochemical test-based screening for colorectal cancer given prior fecal hemoglobin concentrations
Authors: Esther Toes-Zoutendijk, Hilliene J van de Schootbrugge-Vandermeer, Maria A Katsara, Lucie de Jonge, Manon C W Spaander, Anneke J van Vuuren, Folkert J van Kemenade, Evelien Dekker, Iris D Nagtegaal, Monique E van Leerdam, Iris Lansdorp-Vogelaar, Reinier G S Meester
Journal: Clinical Gastroenterology and Hepatology (2024)

This study aimed to provide evidence on the harm-to-benefit ratio of fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening by previous fecal hemoglobin (f-Hb) concentrations, as reflected in the number needed to screen (NNS) and number needed to scope (NNSc).
Chaperone-mediated autophagy modulates Snail protein stability: implications for breast cancer metastasis
Authors: Ki-Jun Ryu, Ki Won Lee, Seung-Ho Park, Taeyoung Kim, Keun-Seok Hong, Hyemin Kim, Minju Kim, Dong Woo Ok, Gu Neut Bom Kwon, Young-Jun Park, Hyuk-Kwon Kwon, Cheol Hwangbo, Kwang Dong Kim, J. Eugene Lee, Jiyun Yoo
Journal: Molecular Cancer (2024)

Breast cancer remains a significant health concern, with triple-negative breast cancer (TNBC) being an aggressive subtype with poor prognosis. Epithelial-mesenchymal transition (EMT) is important in early-stage tumor to invasive malignancy progression. Snail, a central EMT component, is tightly regulated and may be subjected to proteasomal degradation. We report a novel proteasomal independent pathway involving chaperone-mediated autophagy (CMA) in Snail degradation, mediated via its cytosolic interaction with HSC70 and lysosomal targeting, which prevented its accumulation in luminal-type breast cancer cells. Conversely, Snail predominantly localized to the nucleus, thus evading CMA-mediated degradation in TNBC cells. Starvation-induced CMA activation downregulated Snail in TNBC cells by promoting cytoplasmic translocation. Evasion of CMA-mediated Snail degradation induced EMT, and enhanced metastatic potential of luminal-type breast cancer cells. Our findings elucidate a previously unrecognized role of CMA in Snail regulation, highlight its significance in breast cancer, and provide a potential therapeutic target for clinical interventions.
Pandemic risk characterisation of zoonotic influenza A viruses using the Tool for Influenza Pandemic Risk Assessment (TIPRA)
Authors: Reina Yamaji, Wenqing Zhang, Akiko Kamata, Cornelia Adlhoch, David E Swayne, Dmitriy Pereyaslov, Dayan Wang, Gabriele Neumann, Gounalan Pavade, Ian G Barr, Malik Peiris, Richard J Webby, Ron A M Fouchier, Sophie Von Dobschütz, Thomas Fabrizio, Yuelong Shu, Magdi Samaan
Journal: The Lancet Microbe (2024)
Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome
Authors: Shaocong Hou, Hengcai Yu, Caihong Liu, Andrew M F Johnson, Xingfeng Liu, Qian Jiang, Qijin Zhao, Lijuan Kong, Yanjun Wan, Xiaowei Xing, Yibing Chen, Jingwen Chen, Qing Wu, Peng Zhang, Changtao Jiang, Bing Cui, Pingping Li
Journal: Acta Pharmaceutica Sinica B (2024)

Nuclear receptor corepressor (NCoR1) interacts with various nuclear receptors and regulates the anabolism and catabolism of lipids. An imbalance in lipid/energy homeostasis is also an important factor in obesity and metabolic syndrome development. In this study, we found that the deletion of NCoR1 in intestinal epithelial cells (IECs) mainly activated the nuclear receptor PPARα and attenuated metabolic syndrome by stimulating thermogenesis. The increase in brown adipose tissue thermogenesis was mediated by gut-derived tricarboxylic acid cycle intermediate succinate, whose production was significantly enhanced by PPARα activation in the fed state. Additionally, NCoR1 deletion derepressed intestinal LXR, increased cholesterol excretion, and impaired duodenal lipid absorption by decreasing bile acid hydrophobicity, thereby reversing the possible negative effects of intestinal PPARα activation. Therefore, the simultaneous regulatory effect of intestinal NCoR1 on both lipid intake and energy expenditure strongly suggests that it is a promising target for developing metabolic syndrome treatment.
Transipedia.org: k-mer-based exploration of large RNA sequencing datasets and application to cancer data
Authors: Chloé Bessière, Haoliang Xue, Benoit Guibert, Anthony Boureux, Florence Rufflé, Julien Viot, Rayan Chikhi, Mikaël Salson, Camille Marchet, Thérèse Commes, Daniel Gautheret
Journal: Genome biology (2024)

Indexing techniques relying on k-mers have proven effective in searching for RNA sequences across thousands of RNA-seq libraries, but without enabling direct RNA quantification. We show here that arbitrary RNA sequences can be quantified in seconds through their decomposition into k-mers, with a precision akin to that of conventional RNA quantification methods. Using an index of the Cancer Cell Line Encyclopedia (CCLE) collection consisting of 1019 RNA-seq samples, we show that k-mer indexing offers a powerful means to reveal non-reference sequences, and variant RNAs induced by specific gene alterations, for instance in splicing factors.
An innovative strategy harnessing self-activating CAR-NK cells to mitigate TGF-β1-driven immune suppression
Authors: Seung Hun Shin, Young Eun Lee, Han-Na Yoon, Chae Min Yuk, Jun Yop An, Minkoo Seo, Sangwon Yoon, Min-Suk Oh, Sang Chul Shin, Ji Hyung Kim, Yong Jun Kim, Jin-Chul Kim, Song Cheol Kim, Mihue Jang
Journal: Biomaterials (2024)

The dysfunction of natural killer (NK) cells, mediated by transforming growth factor β1 (TGFβ1) within the tumor microenvironment, impedes antitumor therapy and contributes to poor clinical outcomes. Our study introduces self-activating chimeric antigen receptor (CAR)-NK cells that block TGFβ1 signaling by releasing a specifically designed peptide, P6, which targets mesothelin in pancreatic tumors. P6 originates from the interaction sites between TGFβ1 and TGFβ receptor 1 and effectively disrupts TGFβ1's inhibitory signaling in NK cells. Our analysis demonstrates that P6 treatment interrupts the SMAD2/3 pathway in NK cells, mitigating TGFβ1-mediated suppression of NK cell activity, thereby enhancing their metabolic function and cytotoxic response against pancreatic tumors. These CAR-NK cells exhibit potent antitumor capabilities, as evidenced in spheroid cultures with cancer-associated fibroblasts and in vivo mouse models. Our approach marks a substantial advancement in overcoming TGFβ1-mediated immune evasion, offering a promising avenue for revolutionizing cancer immunotherapy.
Platelet transfusion in neonatal intensive care units of 22 European countries: a prospective observational study
Authors: Nina A M Houben, Enrico Lopriore, Karin Fijnvandraat, Camila Caram-Deelder, Marta Aguar Carrascosa, Alain Beuchée, Kristin Brække, Francesco Cardona, Anne Debeer, Sara Domingues, Stefano Ghirardello, Ruza Grizelj, Emina Hadžimuratović, Christian Heiring, Jana Lozar Krivec, Jan Malý, Katarina Matasova, Carmel Maria Moore, Tobias Muehlbacher, Miklos Szabó, Tomasz Szczapa, Gabriela Zaharie, Justine de Jager, Nora Johanna Reibel-Georgi, Helen V New, Simon J Stanworth, Emöke Deschmann, Charles C Roehr, Christof Dame, Saskia le Cessie, Johanna van der Bom, Suzanne Fustolo-Gunnink
Journal: The Lancet Regional Health - Europe (2024)
Glucagon-like peptide-1 receptor agonists significantly affect the quality of bowel preparation for colonoscopy
Authors: Naim Abu-Freha, Avraham Yitzhak, Haim Shirin, Anat Nevo-Shor, Jafar Abu-Jaffar, Samer Abu-Rafe, Yaser Afianish, Daniel L. Cohen, Anton Bermont
Journal: Endoscopy (2024)

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) affect gastrointestinal motility, slowing gastric emptying and colonic transit. GLP-1RAs have an impact on gastric residue before endoscopy, but only limited data are available regarding its effect on the adequacy of colonic preparation. We investigated the association between GLP-1RA use and inadequate bowel preparation (IBP) for colonoscopy.
5-year vaccine protection following a single dose of Vi-tetanus toxoid conjugate vaccine in Bangladeshi children (TyVOID): a cluster randomised trial
Authors: Firdausi Qadri, Farhana Khanam, Yiyuan Zhang, Prasanta Kumar Biswas, Merryn Voysey, Yama F Mujadidi, Sarah Kelly, Amirul Islam Bhuiyan, Nazmul Hasan Rajib, Ismail Hossen, Nazia Rahman, Sadia Islam, Virginia E Pitzer, Young Chan Kim, John D Clemens, Andrew J Pollard, Xinxue Liu
Journal: The Lancet (2024)
Efficacy of a culturally adapted, cognitive behavioural therapy-based intervention for postnatal depression in British south Asian women (ROSHNI-2): a multicentre, randomised controlled trial
Authors: Nusrat Husain, Farah Lunat, Karina Lovell, Jahanara Miah, Carolyn A. Chew-Graham, Penny Bee, Ahmed Waqas, Matthias Pierce, Deepali Sharma, Najia Atif, Saadia Aseem, Kamaldeep Bhui, Peter Bower, Traolach Brugha, Nasim Chaudhry, Akbar Ullah, Linda Davies, Nadeem Gire, Joe Kai, Jillian Morrison, Naeem Mohmed, Shanaya Rathod, Najma Siddiqi, Siham Sikander, Waquas Waheed, Ilyas Mirza, Christopher Williams, Nosheen Zaidi, Richard Emsley, Atif Rahman, Richard Morriss
Journal: The Lancet (2024)

Postnatal depression necessitates timely and effective interventions to mitigate adverse maternal and child outcomes in the short term and over the life course. British south Asian women with depression are often underserved and undertreated due to stigma, language barriers, and cultural barriers. This trial aimed to test the clinical efficacy of a culturally adapted, group cognitive behavioural therapy (CBT)-based intervention, the Positive Health Programme (PHP), delivered by non-specialist health workers for postnatal depression in British south Asian women.
Adjunctive linezolid versus clindamycin for toxin inhibition in β-lactam-treated patients with invasive group A streptococcal infections in 195 US hospitals from 2016 to 2021: a retrospective cohort study with target trial emulation
Authors: Ahmed Babiker, Sarah Warner, Xiaobai Li, Emad A Chishti, Eltaib Saad, Bruce J Swihart, John P Dekker, Morgan Walker, Alexander Lawandi, Sameer S Kadri
Journal: The Lancet Infectious Diseases (2024)