tbuckley/cabot-search huggingface dataset:
Extracellular Vesicle‐Based Antitumor Nanomedicines
Authors: Mingfeng Li, Yanfei Liu, Fei Liu, Qiwen Chen, Lishang Xu, Zhongyu Cheng, Yifu Tan, Zhenbao Liu
Journal: Advanced Healthcare Materials (2025)

Abstract Extracellular vesicles (EVs) have emerged as promising bioactive carriers for delivering therapeutic agents, including nucleic acids, proteins, and small‐molecule drugs, owing to their excellent physicochemical stability and biocompatibility. However, comprehensive reviews on the various types of EV‐based nanomedicines for cancer therapy remain scarce. This review explores the potential of EVs as antitumor nanomedicines. Methods for EV extraction, drug loading, and engineering modifications are systematically examined, and the strengths and limitations of these technical approaches are critically assessed. Additionally, key strategies for developing EV‐based antitumor therapies are highlighted. Finally, the opportunities and challenges associated with advancing EVs toward clinical translation are discussed. With the integration of multiple disciplines, robust EV‐based therapeutic platforms are expected to be manufactured to provide more personalized and effective solutions for oncology patients.
Comorbidity trajectories before and after the diagnosis of heart failure: A <scp>UK</scp> Biobank cohort study
Authors: Hugo MacGowan, Oliver I. Brown, Michael Drozd, Andrew M.N. Walker, Marilena Giannoudi, Sam Straw, Maria F. Paton, John Gierula, Melanie McGinlay, Kathryn J. Griffin, Klaus K. Witte, Mark T. Kearney, Richard M. Cubbon
Journal: European Journal of Heart Failure (2025)
Tissue‐Adhesive and Antibacterial Hydrogel Promotes MDR Bacteria‐Infected Diabetic Wound Healing via Disrupting Bacterial Biofilm, Scavenging ROS and Promoting Angiogenesis
Authors: Yang Gao, Xinxin Chen, Zheng Zou, Desheng Qi, Yujia Geng, Zhen Wang, Zhen Zhang, Chaoliang He, Jiaao Yu
Journal: Advanced Healthcare Materials (2025)

Effective treatment of diabetic wounds remains challenging because of multidrug-resistant (MDR) bacterial infections, excessive oxidative stress, and impaired angiogenesis. In this study, a tissue-adhesive and antibacterial hydrogel incorporating MXene and deferoxamine (DFO)-loaded microspheres is developed for the treatment of MDR bacteria-infected diabetic wounds. The hydrogel is built based on covalent crosslinking between ε-poly(L-lysine) and o-phthalaldehyde-terminated four-arm poly(ethylene glycol). The hydrogel exhibited excellent mechanical properties, tissue adhesion strength, biocompatibility, and biodegradability. Under near-infrared (NIR) irradiation, the MXene converted light into heat and elevated the local temperature rapidly, enabling the rapid disintegration of MDR bacterial biofilms. Simultaneously, the hydrogel exerted inherent antibacterial activity, persistently killing planktonic bacteria, and effectively controlling wound infections. The encapsulated DFO is then released from the hydrogel in a sustained and controlled manner, and promoted angiogenesis during diabetic wound healing. Additionally, MXenes can scavenge excessive reactive oxygen species and alleviate wound inflammation. In the methicillin-resistant Staphylococcus aureus-infected diabetic wound model in mice, the composite hydrogel along with NIR irradiation efficiently reduced the infectious bacteria, and accelerated the wound healing by promoting angiogenesis and alleviating inflammation. This composite hydrogel has great clinical potential for the treatment of diabetic wounds, particularly in challenging healing environments involving motion and infection.
Peptide‐Based Functional Amyloid Hydrogel Enhances Wound Healing in Normal and Diabetic Rat Models
Authors: Ranjit Shaw, Komal Patel, Niyamat M. A. Chimthanawala, Sadhana Sathaye, Samir K Maji
Journal: Advanced Healthcare Materials (2025)

Abstract The inability to heal on time is a key component of chronic wounds, which can result in economic, psychological, and physiological burdens. Hydrogels based on amyloid can imitate the extracellular matrix and function as scaffolds for healing wounds. In this direction, a wound dressing inspired by peptide‐based amyloid hydrogel is fabricated here. The results demonstrate that the amyloid hydrogel improves the three essential components of skin tissue regeneration: cell migration, proliferation, and collagen remodeling, both in vitro and in vivo. Furthermore, the amyloid hydrogel accelerates wound healing and promotes wound closure within 9 and 15 d in normal and diabetic rats, respectively. Microscopic evaluation of the wound region demonstrates the ultimate stages of regeneration and skin reformation toward normal skin compared to the untreated wound. Hematoxylin and eosin‐stained hydrogel‐treated wound sites reveal faster dermal bridging, angiogenesis, and epidermal repair in both acute and chronic conditions. The hydrogel creates an environment that encourages the growth of dermal fibroblasts and the release of cytokines, decreasing inflammation with concomitant enhancement of collagen production at the site of injury. Thus, these findings suggest that amyloid‐based hydrogel can be a promising candidate for application in acute and chronic wound healing.
Nitrogen‐Doped Ultrananocrystalline Diamond – Optoelectronic Biointerface for Wireless Neuronal Stimulation
Authors: Yue Yao, Arman Ahnood, Andre Chambers, Wei Tong, Steven Prawer
Journal: Advanced Healthcare Materials (2025)

Abstract This study presents a semiconducting optoelectronic system for light‐controlled non‐genetic neuronal stimulation using visible light. The system architecture is entirely wireless, comprising a thin film of nitrogen‐doped ultrananocrystalline diamond directly grown on a semiconducting silicon substrate. When immersed in a physiological medium and subjected to pulsed illumination in the visible (595 nm) or near‐infrared wavelength (808 nm) range, charge accumulation at the device‐medium interface induces a transient ionic displacement current capable of electrically stimulating neurons with high temporal resolution. With a measured photoresponsivity of 7.5 mA W −1 , the efficacy of this biointerface is demonstrated through optoelectronic stimulation of degenerate rat retinas using 595 nm irradiation, pulse durations of 50–500 ms, and irradiance levels of 1.1–4.3 mW mm −2 , all below the safe ocular threshold. This work presents the pioneering utilization of a diamond‐based optoelectronic platform, capable of generating sufficiently large photocurrents for neuronal stimulation in the retina.
Defect‐Rich BiO₂₋<sub>x</sub>‐BP Composite Nanoplatform: A Synergistic Approach for X‐Ray and Near‐Infrared‐Enhanced Cancer Radiodynamic Therapy
Authors: Hanping Fu, Li Feng, Qingshuang Liang, Xiufeng Xiao
Journal: Advanced Healthcare Materials (2025)

Abstract Cancer treatment faces significant challenges, including hypoxia within the tumor microenvironment, which limits the efficacy of conventional therapies. This study introduces a multifunctional nanoplatform comprising defect‐rich BiO₂₋ x and black phosphorus (BP) nanosheets to address this issue. BiO₂₋ x effectively catalyzes the decomposition of tumor‐overexpressed H₂O₂ into oxygen, mitigating hypoxia. Its high atomic number enhances X‐ray absorption, increasing local radiation doses. When combined with BP, BiO₂₋ x forms a heterojunction that produces secondary electrons, generating reactive oxygen species (ROS) like ·OH under X‐ray irradiation. Additionally, under 808 nm near‐infrared (NIR) light, the platform exhibits strong photothermal effects, further enhancing cancer cell apoptosis. In vitro and in vivo experiments demonstrate the nanoplatform's remarkable ability to synergize radiotherapy, photothermal therapy, and radiodynamic therapy, resulting in significant tumor suppression without adverse effects on major organs. This innovative approach highlights the potential of BiO₂₋ x ‐BP composites for addressing hypoxia and achieving multimodal cancer therapy.
Ferric Carboxymaltose (<scp>FCM</scp>)–Associated Hypophosphatemia (<scp>HPP</scp>): A Systematic Review
Authors: Joseph Magagnoli, Kevin Knopf, William J. Hrushesky, Kenneth R. Carson, Charles L. Bennett
Journal: American Journal of Hematology (2025)

ABSTRACT Background Since 2015, ferric carboxymaltose (FCM), an intravenous (IV) iron formulation used for treating iron deficiency anemia (IDA), has been associated with an increasing number of reported hypophosphatemia (HPP) cases. Information on HPP clinical manifestations and incidence has not been reviewed. Methods We reviewed HPP‐associated adverse events reported to the FDA, case reports, case series, observational databases, clinical trials, meta‐analyses, and FDA‐approved labels. Our analysis found that FCM‐associated HPP is a clinically important adverse drug reaction (ADR). The most common clinical manifestations are general weakness, fatigue, bone pain, muscle pain, osteomalacia, and fractures. Information on rates of FCM‐associated HPP was from a review of clinical trials, observational databases, systematic reviews, and meta‐analyses. Results Clinical trials comparing FCM with other IV iron preparations identified FCM‐associated HPP rates between 50% and 92% versus 2% and 8% with other IV iron formulations. Meta‐analyses and systematic reviews confirmed these numbers. FDA‐approved FCM labels do not include details of available ADR information in case reports, case series, observational databases, randomized trials, and meta‐analyses. Conclusion We conclude that although the FDA‐approved FCM Prescribing Label was updated in 2023, more robust recommendations on FCM‐associated HPP are needed to prevent negative outcomes including osteomalacia and fractures. For patient safety, FCM label should advise monitoring serum phosphate levels prior to initiating first doses and before subsequent doses for all patients. Given differences between the FDA‐approved FCM label and data reviewed herein, clinicians must be educated about FCM‐associated HPP, difficulties treating HPP cases, and should consider administering other IV iron formulations that have lower rates of HPP.
Polylactic acid electrospun membranes coated with chiral hierarchical-structured hydroxyapatite nanoplates promote tendon healing based on a macrophage-homeostatic modulation strategy
Authors: Gang Luo, Juehong Li, Shuai Chen, Zhengqiang Yuan, Ziyang Sun, Tengfei Lou, Zhenyu Chen, Hang Liu, Chao Zhou, Cunyi Fan, Hongjiang Ruan
Journal: Bioactive Materials (2025)
Minimal Residual Disease–Based End Point for Accelerated Assessment of Clinical Trials in Multiple Myeloma: A Pooled Analysis of Individual Patient Data From Multiple Randomized Trials
Authors: Qian Shi, Bruno Paiva, Levi D. Pederson, Natalie Dimier, Ela Talpes, Thomas J. Prior, Alberto Orfao, Philippe Moreau, Pieter Sonneveld, Shaji K. Kumar, Jesse G. Dixon, Reshma Patel, Blake J. Bartlett, Jordan Schecter, Phillip McCarthy, Dirk Hose, Anja Seckinger, D'Agostino Mattia, Hartmut Goldschmidt, Stefania Oliva, Roger G. Owen, Kenneth C. Anderson, Jesús San-Miguel, Brian G.M. Durie, Nikhil Munshi
Journal: Journal of Clinical Oncology (2025)

PURPOSE Newly approved drugs and combinations treating multiple myeloma (MM) have resulted in substantial improvements in patients' survival. To deliver rapid access to newer therapies, an earlier end point to expedite clinical trials is needed. Our objective was to evaluate the minimal residual disease–negative complete response (MRD-CR) as an intermediate end point for progression-free survival (PFS) and overall survival (OS) in newly diagnosed (ND) transplant-eligible (NDTE) patients, ND transplant-ineligible (NDTinE) patients, and patients with relapsed/refractory (RR) MM. PATIENTS AND METHODS Individual patient data from 20 randomized multicenter trials were collected. Eleven studies (4,773 patients) with sufficient data were analyzed to evaluate whether 9- or 12-month MRD-CR classified at a 10 –5 threshold could be reasonably likely to predict the clinical benefit of new agents regarding PFS and OS. Global odds ratio (OR) was estimated using the bivariate Plackett Copula model. Supportive evaluation included correlations of the treatment effects on MRD-CR end points and PFS/OS, evaluated by both linear regression ( R 2 weighted least squared ) and Copula ( R 2 Copula ) models. RESULTS The analysis demonstrated that both 9- and 12-month MRD-CR strongly correlated with PFS at patient level in NDTE patients, NDTinE patients, and patients with RRMM. Global ORs ranged from 3.06 to 16.24, all with 95% CIs excluding 1.0. Encouraging trial-level correlations ( R 2 , 0.61-0.70) were observed by pooling three populations and were stronger ( R 2 , 0.67-0.78) in the ND population. Similar results were observed for OS. CONCLUSION Our findings provided the support for use of MRD-CR classified at a 10 –5 threshold at either 9 or 12 months after starting of the treatment, as an intermediate end point to support accelerated approvals, in future trials in NDTE patients, NDTinE patients, and patients with RRMM.
Coactivation of innate immune suppressive cells induces acquired resistance against combined TLR agonism and PD-1 blockade
Authors: Hitomi Nishinakamura, Sayoko Shinya, Takuma Irie, Shugo Sakihama, Takeo Naito, Keisuke Watanabe, Daisuke Sugiyama, Motohiro Tamiya, Tatsuya Yoshida, Tetsunari Hase, Takao Yoshida, Kennosuke Karube, Shohei Koyama, Hiroyoshi Nishikawa
Journal: Science Translational Medicine (2025)

Immune checkpoint blockade therapy has been successfully applied in clinical settings as a standard therapy for many cancer types, but its clinical efficacy is restricted to patients with immunologically hot tumors. Various strategies to modify the tumor microenvironment (TME), such as Toll-like receptor (TLR) agonists that can stimulate innate immunity, have been explored but have not been successful. Here, we show a mechanism of acquired resistance to combination treatment consisting of an agonist for multiple TLRs, OK-432 (Picibanil), and programmed cell death protein 1 (PD-1) blockade. Adding the TLR agonist failed to convert the TME from immunogenically cold to hot and did not augment antitumor immunity, particularly CD8 + T cell responses, in multiple animal models. The failure was attributed to the coactivation of innate suppressive cells, such as polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) expressing CXCR2, through high CXCL1 production by macrophages in the TME upon OK-432 treatment. A triple combination treatment with OK-432, PD-1 blockade, and a CXCR2 neutralizing antibody overcame the resistance induced by PMN-MDSCs, resulting in a stronger antitumor effect than that of any dual combinations or single treatments. The accumulation of PMN-MDSCs was similarly observed in the pleural effusions of patients with lung cancer after OK-432 administration. We propose that successful combination cancer immunotherapy intended to stimulate innate antitumor immunity requires modulation of unwanted activation of innate immune suppressive cells, including PMN-MDSCs.
Addressing the Burden of Steatotic Liver Disease: The Role of Transient Elastography: Correspondence to editorial on “Vibration-controlled transient elastography in shaping the epidemiology and management of steatotic liver disease”
Authors: Donghee Kim, Pojsakorn Danpanichkul, Karn Wijarnpreecha, George Cholankeril, Rohit Loomba, Aijaz Ahmed
Journal: Clinical and Molecular Hepatology (2025)

Addressing the Burden of Steatotic Liver Disease: The Role of Transient Elastography: Correspondence to editorial on "Vibration-controlled transient elastography in shaping the epidemiology and management of steatotic liver disease"
GOLM1 and Bile Acid Synthesis: Correspondence to the Editorial “Bridging the Gap: The GOLM1-OPN-ABCG5 Axis in MASH and Gallstone Disease”
Authors: Yi-Tong Li, Wei-Qing Shao, Zhen-Mei Chen, Jing Lin, Jin-Hong Chen
Journal: Clinical and Molecular Hepatology (2025)
Systematic literature review informing the EULAR points to consider for patient education in physical activity and self-management of pain during transitional care
Authors: Javier Courel-Ibáñez, Rafael Prieto-Moreno, Erica Briones-Vozmediano, Patrocinio Ariza-Vega, Saskya Angevare, Jordi Anton, Ilaria Bini, Daniel Clemente, Matilde Correia, Wendy Costello, Diederik De Cock, Andrea Domjan, Leticia Leon, Andrea Marques, Kirsten Minden, Ana Filipa Mourão, Aurelie Najm, Seza Özen, Georgina Pimentel, Zainab Saleem, Tomas Vetrovsky, Nico Wulffraat, Andrea Zacarias, Yeliz Prior, Loreto Carmona, Fernando Estévez-López
Journal: Annals of the Rheumatic Diseases (2025)

To synthesise existing evidence on transitional care programmes for young people with juvenile-onset rheumatic and musculoskeletal diseases (jRMDs), focusing on their structure and implementation, the qualitative experiences and perceptions of those involved, and the quantitative outcomes associated with these programmes. Together with additional information, these insights have informed the European Alliance of Associations for Rheumatology (EULAR) Points to Consider for patient education in physical activity and self-management of pain in jRMDs during transitional care. A systematic literature review was conducted with a broadened scope beyond patient education in physical activity and self-management of pain to provide a comprehensive overview of transitional care in rheumatology, aiming to optimise current strategies, support evidence-based approaches, and identify areas for clinical improvement. The search was conducted in PubMed and the Cochrane Library from inception until November 1, 2023. Descriptive, qualitative, and quantitative studies were included. Two researchers independently conducted the search, screening, data extraction, and quality assessment. From 31 studies, we identified 18 transitional care programmes with key approaches, including individualised and developmentally appropriate plans that often integrate educational strategies. These programmes, which generally aim to increase readiness to transfer, health-related quality of life, and continuity of care, frequently involved multidisciplinary teams and early intervention strategies. Young people with jRMDs and their families reported satisfaction with these transitional care experiences, particularly valuing early self-management support. While these programmes showed potential in promoting positive health outcomes and clinical practices, quantitative evidence supporting their effectiveness is limited, with few experimental studies confirming consistent benefits. This systematic review highlights the diverse yet fragmented approaches in transitional care for jRMDs, emphasising the need for stronger quantitative evidence. Thus, it is important to conduct further experimental research to optimise existing programmes or develop new ones, ultimately contributing to a smoother transition to adult care and improved long-term outcomes.
Correction: A simplified, two-factor clinical prognostic scoring system for patients with newly diagnosed Hodgkins Lymphoma
Authors: Charanpreet Singh, Lekshmon KS, Arihant Jain, Deepesh Lad, Alka Khadwal, Rajender Basher, Amanjit Bal, Radhika Srinivasan, Subhash Varma, Pankaj Malhotra, Gaurav Prakash
Journal: Blood Cancer Journal (2025)
Lineage-Specific Class-A GPCR Dynamics Reflect Diverse Chemosensory Adaptations in Lophotrochozoa
Authors: Rohan Nath, Biswajit Panda, Siuli Rakesh, Arunkumar Krishnan
Journal: Molecular Biology and Evolution (2025)

Abstract Detecting external chemosensory cues via Class-A G protein-coupled receptors (GPCRs) is crucial for a multitude of behavioral and biological functions, influencing animal evolution and ecological adaptations. While extensively studied in vertebrates and echinoderms, the role of GPCR-mediated chemoreception in major protostome clades like Lophotrochozoa remains obscure despite their remarkable ecological adaptations across diverse aquatic and terrestrial environments. Utilizing 238 lophotrochozoan genomes across eight phyla, we conducted a large-scale comparative genomics analysis to identify lineage-specific expansions (LSEs) of Class-A GPCR subsets that are likely adapted for chemoreception. Using phylogeny and orthology-inference-based clustering, we distinguished these expansions from conserved orthogroups of prospective endogenous ligand-binding Class-A GPCR subsets. Across phyla, LSEs correlated with adaptations to various habitats, ecological niches, and lifestyles, while the influence of whole-genome duplications in driving these LSEs appeared to be less significant. Species adapted to various coastal, freshwater, and terrestrial habitats across several classes of Mollusca, Annelida, and other analyzed phyla exhibit large and diverse LSEs, while adaptations to extreme deep-sea environments, parasitic lifestyles, sessile behaviors, or alternative chemosensory mechanisms consistently exhibit reductions. Sequence heterogeneity, signatures of positive selection, and conformational flexibility in ligand-binding pockets further highlighted adaptations to environmental signals. In summary, the evolutionary dynamics of Class-A GPCRs in lophotrochozoans reveal a widespread pattern of LSEs driven by adaptations for chemoreception across diverse environmental niches, mirroring the trends and prominent roles seen in deuterostome lineages. The comprehensive datasets spanning numerous genomes offer a valuable foundation for advancing GPCR-mediated chemoreception studies in Lophotrochozoa.
Engineered In Vitro Multi‐Cell Type Ventricle Model Generates Long‐Term Pulsatile Flow and Modulates Cardiac Output in Response to Cardioactive Drugs
Authors: Christoph Kuckelkorn, Ebru Aksoy, Natalija Stojanovic, Laila Oulahyane, Mira Ritter, Kurt Pfannkuche, Horst Fischer
Journal: Advanced Healthcare Materials (2025)

Abstract Cardiac in vitro models serve as promising platforms for physiological and pathological studies, drug testing, and regenerative medicine. This study hypothesizes that immobilizing cardiomyocytes derived from human induced pluripotent stem cells (iPSC‐CMs) on a biofunctionalized, hemispherical membrane can generate pulsatile flow through synchronized contractions, thus offering as an in vitro left ventricle model. To test this, a ventricle using a polydimethylsiloxane (PDMS) membrane coated with polydopamine and laminin 511 E8 fragments is engineered. Human iPSC‐CMs are cultured on these membranes, alone or in co‐culture with cardiac fibroblasts or endothelial cells, for 28 and 14 days, respectively, in a newly developed bioreactor. Flow measurements track beating and flow generation, while drug response, cardiac gene expression, and cell morphology are analyzed. The engineered ventricles maintain continuous beating and flow, achieving a theoretical cardiac output of up to 4 µL min −1 over 28 days, indicating stable cell adhesion and synchronized contraction. Cardiomyocytes respond to cardioactive drugs (carbachol, isoproterenol) and show expected changes in heart rate and cardiac output. In conclusion, the results demonstrate that the proposed engineered ventricle can serve as an in vitro left ventricle model by supporting cardiomyocyte culture and differentiation, generating long‐term stable flow, and responding physiologically to cardioactive drugs.
A natural biological adhesive from slug mucus for wound repair
Authors: Zhengchao Yuan, Siyuan Wu, Liwen Fu, Xinyi Wang, Zewen Wang, Muhammad Shafiq, Hao Feng, Lu Han, Jiahui Song, Mohamed El-Newehy, Meera Moydeen Abdulhameed, Yuan Xu, Xiumei Mo, Shichao Jiang
Journal: Bioactive Materials (2025)