tbuckley/cabot-search huggingface dataset:
THE PSYCHOSOMATIC SEMINAR AS A MEANS OF CONTINUED CONSULTATION TO PHYSICIANS
Authors: I N BERLIN
Journal: Annals of Internal Medicine (1955)

Article1 September 1955THE PSYCHOSOMATIC SEMINAR AS A MEANS OF CONTINUED CONSULTATION TO PHYSICIANSI. N. BERLIN, M.D.I. N. BERLIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-3-567 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiscussions with internist and general practitioner friends about the handling of difficult psychosomatic patients have led me to talk with them about how such problems are handled in seminars at a university hospital†with medical residents. Each physician with whom I have talked has indicated his feeling that such regular seminar discussions with a psychiatric consultant would greatly facilitate his work with patients. At this writing such a group has not been formed, but a local psychosomatic society is considering the possibility of such continued group discussions as a part of their program. The response of physicians to such an... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Received for publication February 15, 1955.From the University of California School of Medicine, Department of Psychiatry and The State of California, Department of Mental Hygiene, The Langley Porter Clinic, San Francisco, California.†Seminar for house staff of the University of California School of Medicine, Psychosomatic Clinic, Robert Credé, M.D., Assistant Professor of Medicine in charge of the Psychosomatic Clinic, Teaching and Seminars.‡Personal communication from Dr. Robert Credé. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAN EARLY RENAL LESION IN SYSTEMIC LUPUS ERYTHEMATOSUS. 1 September 1955Volume 43, Issue 3Page: 567-574KeywordsAsthmaEmotionsPeptic ulcersPsychiatry and mental health Issue Published: 1 September 1955 PDF downloadLoading ...
ABO Blood Group Mismatch Does Not Affect Survival Or Transfusion Requirements In Patients Undergoing Alemtuzumab-Based Reduced-Intensity Conditioned Hematopoietic Stem Cell Transplantation
Authors: Charlotte K Brierley, Timothy J Littlewood, Andrew Peniket, Richard Gregg, Janice Ward, Andrew Clark, Anne Parker, Ram Malladi, Patrick G Medd
Journal: Blood (2013)
Frequency of HLA-B27 and its alleles in patients with fiessinger-leroy-reiter syndrome: comparison with the frequency in other spondyloarthropathies and a healthy control population
Authors: P. D. Sampaio-Barros, R. A. Conde, E. A. Donadi, L. T. Costallat, M. B. Bertolo, A. M. Samara
Journal: Annals of the Rheumatic Diseases (2005)
Abstract 13296: Impact of Microvascular Dysfunction on the Incidence of Acute Kidney Injury and In-Hospital Suvival After Primary Coronary Intervention for Acute Myocardial Infarction
Authors: Koichi Tamita, Atsuhi Yamamuro, Shuichiro Kaji, Takeshi Kitai, Yutaka Furukawa, Takashi Akasaka
Journal: Circulation (2010)

Background: Recent studies have shown that severe microvascular dysfunction (MVD) is a strong predictor of future mortality in patients with acute myocardial infarction (AMI). Acute kidney injury (...
Regulation of Cholesterol Metabolism in the Dog
Authors: Demetrius Pertsemlidis, Ernest H. Kirchman, E. H. Ahrens
Journal: Journal of Clinical Investigation (1973)

In six adult pedigreed dogs the effects of high-cholesterol diets or bile diversion on the sizes of body cholesterol pools were studied at autopsy. Total body cholesterol was determined by measuring the cholesterol content of discrete organs and of the eviscerated carcass: neither cholesterol feeding nor bile diversion had altered total body cholesterol or the cholesterol content of individual organs and tissues. These results validated the conclusion based on sterol balance data obtained during life, that high-cholesterol feeding did not lead to substantial expansion of tissue cholesterol pools. THE TOTAL AMOUNT OF EXCHANGEABLE CHOLESTEROL IN THE ANIMALS WITH AN INTACT ENTEROHEPATIC CIRCULATION, WHEN ESTIMATED FROM ISOTOPIC DATA, WAS ESSENTIALLY THE SAME AS THAT MEASURED CHEMICALLY: this indicated that there was little or no nonexchangeable cholesterol in these dogs, except in skin and nervous tissue, regardless of the cholesterol content of the diet. This correspondence of estimates was not obtained in the bile-diverted dogs: we propose that the defect in the isotopic estimates was due to the accelerated rate of cholesterol synthesis in these animals. Gross and microscopic morphology of all organs and tissues was examined. Abnormal findings were limited to the biliary tract and the urinary collecting system of the two bile-diverted dogs: multiple bilirubinate gallstones were found, and mild pyelitis and ureteritis were present on the side of the bilio-renal shunt, but the urinary bladder was normal. Histologic evidence of moderate degree of cholangitis was found in one of the two bile-shunted dogs, but in neither dog was there evidence of impedance of bile flow.
Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity
Authors: Benjamin M Gaub, Michael H Berry, Amy E Holt, Ehud Y Isacoff, John G Flannery
Journal: Molecular Therapy (2015)

Retinal disease is one of the most active areas of gene therapy, with clinical trials ongoing in the United States for five diseases. There are currently no treatments for patients with late-stage disease in which photoreceptors have been lost. Optogenetic gene therapies are in development, but, to date, have suffered from the low light sensitivity of microbial opsins, such as channelrhodopsin and halorhodopsin, and azobenzene-based photoswitches. Several groups have shown that photoreceptive G-protein-coupled receptors (GPCRs) can be expressed heterologously, and photoactivate endogenous Gi/o signaling. We hypothesized such a GPCR could increase sensitivity due to endogenous signal amplification. We targeted vertebrate rhodopsin to retinal ON-bipolar cells of blind rd1 mice and observed restoration of: (i) light responses in retinal explants, (ii) visually-evoked potentials in visual cortex in vivo, and (iii) two forms of visually-guided behavior: innate light avoidance and discrimination of temporal light patterns in the context of fear conditioning. Importantly, both the light responses of the retinal explants and the visually-guided behavior occurred reliably at light levels that were two to three orders of magnitude dimmer than required for channelrhodopsin. Thus, gene therapy with native light-gated GPCRs presents a novel approach to impart light sensitivity for visual restoration in a useful range of illumination.
Abstract 17293: Dynamic Structure Changes of SERCA in Live Cells Revealed by Fluorescence Microscopy of 2-Color SERCA Constructs
Authors: Zhihong Hu, Zhan Jia Hou, Daniel Blackwell, Sandeep Pallikkuth, Seth Robia
Journal: Circulation (2010)

Background: Optimal calcium handling is important for normal cardiac function, and the sarcoendoplasmic calcium ATPase (SERCA) plays a critical role in calcium uptake during the diastole. X-ray cry...
Aminoaciduria Following Total-Body Irradiation in the Human&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Elaine J. Katz, Robert J. Hasterlik
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article Aminoaciduria Following Total-Body Irradiation in the Human Get access Elaine J. Katz, Elaine J. Katz Division of Biological and Medical Research, and Health Services Division, Argonne National Laboratory, Lemont, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert J. Hasterlik Robert J. Hasterlik Division of Biological and Medical Research, and Health Services Division, Argonne National Laboratory, Lemont, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 4, February 1955, Pages 1085–1107, https://doi.org/10.1093/jnci/15.4.1085 Published: 01 February 1955 Article history Received: 08 November 1954 Published: 01 February 1955
VIRUS DISEASES OF ANIMALS TRANSMISSIBLE TO MAN
Authors: K. F. Meyer
Journal: Annals of Internal Medicine (1934)

Article1 November 1934VIRUS DISEASES OF ANIMALS TRANSMISSIBLE TO MANK. F. MEYERK. F. MEYERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-5-552 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInfections or diseases of animals associated with or due to incitants generally designated as viruses, since 1892, have attracted more and more attention. In fact, these maladies, single or in epidemic distribution, have assumed an important position in the realm of the heterogeneous infection chains.The insect-borne diseases, yellow fever, dengue, pappataci fever, Rift Valley fever, etc., are caused by filterable incitants, which localize and multiply in the poikilothermic hosts and, consequently, are classed with the heterogeneous infections. Between the causative agent of the disease and the poikilothermic host, a specific mutual relationship exists and the insect (mosquito) is not... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Read at the Chicago meeting of the American College of Physicians, April 16, 1934.From the George Williams Hooper Foundation, University of California, San Francisco, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVertebrate Reservoirs of Arboviruses: Myth, Synonym of Amplifier, or Reality?Die Psittacosis (Papageienkrankheit) in den Jahren 1931–1935 1 November 1934Volume 8, Issue 5Page: 552-569KeywordsDengue feverFeversInfectious diseases ePublished: 1 December 2008 Issue Published: 1 November 1934 PDF downloadLoading ...
Abstract 2334: The Absence of Left Ventricular Hypertrophy in Patients with Severe Isolated Valvular Aortic Stenosis and Normal Left Ventricular Systolic Function; Echocardiographic, Clinical and Prognostic Characteristics
Authors: Eddy Barasch, Michael Passick, Florentina Petillo, Jing Han, Alan S. Katz, Nathaniel Reichek
Journal: Circulation (2006)
THE COLLEGE AND THE WAR
Authors: Edward L. Botz
Journal: Annals of Internal Medicine (1943)

Editorial1 June 1943THE COLLEGE AND THE WAREDWARD L. BOTZEDWARD L. BOTZSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-6-1020 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe broad educational program of the American College of Physicians was becoming firmly established as the war clouds began to gather. Rooted in the rich soil of medical science with a national faculty unsurpassed for its quality of teaching and research, the annual sessions of the College, the post-graduate courses, the regional meetings and the research fellowships were rapidly extending the influence of the College. These activities were directed to a growing body of physicians diligently bent on improving their knowledge and experience by following close on the heels of a band of brilliant teachers.Wise leadership in the College,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC-V(S) USNR*The opinions and assertions contained herein are those of the author and are not to be construed as those of the Navy or of the naval service at large. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1943Volume 18, Issue 6Page: 1020-1022KeywordsFellowshipsResearch quality assessment Issue Published: 1 June 1943 PDF downloadLoading ...
Abstract 16801: Factors Associated With Mortality for Infants Requiring Postoperative Extracorporeal Membrane Oxygenation Following Stage 1 Palliation for Hypoplastic Left Heart Syndrome
Authors: Elizabeth Sherwin, Joshua Salvin, Kimberlee Gauvreau, Mark Scheurer, Peter Rycus, Peter Laussen, Ravi Thiagarajan
Journal: Circulation (2010)

Background: Patients with hypoplastic left heart syndrome (HLHS) undergoing stage 1 palliation (S1P) comprise a large percentage of patients supported with extracorporeal membrane oxygenation (ECMO) for postoperative cardiopulmonary failure. We report survival to hospital discharge in a large cohort of HLHS patients who required ECMO support following S1P, and analyze factors associated with mortality. Methods: All neonates who underwent S1P for HLHS, required postoperative ECMO support, and were reported to the Extracorporeal Life Support Organization (ELSO) Registry during 2000 - 2009 were included. Survival to hospital discharge was computed. Factors associated with hospital mortality were assessed using multivariable logistic regression analysis. Results: Among 738 neonates with HLHS who underwent postoperative ECMO support following S1P (762 runs; 25% of neonatal cardiac ECMO runs), overall survival was 31%. Median age at ECMO was 7 days (IQR 4, 11), weight 3 kg (IQR 2.7, 3.4), and time from surgery ...
Abstract P244: Measurement Properties of the Center of Epidemiologic Studies-Depression Scale (CESD-10): Findings from the SOL Sociocultural Ancillary Study
Authors: Patricia Gonzalez, Orit Birnbaum-Weitzman, Elena Navas-Nacher, Linda C Gallo, Alvaro Camacho, Christina Buelna, Sheila F Castaneda, Gregory T Talavera, Frank Penedo, Carmen Isasi, Sylvia Wassertheil-Smoller
Journal: Circulation (2013)
Impact of prior lamivudine use on the antiviral efficacy and development of resistance to entecavir in chronic hepatitis B patients
Authors: Joo An Hwang, Kee Bum Kim, Min Jae Yang, Sun Gyo Lim, Jae Chul Hwang, Jae Youn Cheong, Sung Won Cho, Soon Sun Kim
Journal: Clinical and Molecular Hepatology (2015)

Background/Aims To determine the efficacies of entecavir (ETV) in nucleos(t)ide analogue (NA)-naÃ¯ve chronic hepatitis B (CHB) patients and in those with prior lamivudine (LAM) use who did not develop resistance. Methods We retrospectively enrolled 337 patients with CHB who were treated with ETV (0.5 mg daily) for at least 30 months. The study included 270 (80.1%) NA-naÃ¯ve patients and 67 (19.9%) LAM-use patients. Ten of the LAM-use patients were refractory to LAM therapy without developing resistance. Results Genotypic resistance to ETV developed more frequently in the LAM-use group (13.1%) than in the NA-naÃ¯ve group (2.6%) at 60 months (P=0.009). In subgroup analysis, after excluding the 10 patients who were refractory to LAM therapy, the cumulative probability of ETV resistance did not differ significantly between the two groups (P=0.149). Prior LAM refractoriness and a higher hepatitis B virus DNA level at month 12 were independent predictive factors for the development of ETV resistance. Conclusions ETV resistance developed more frequently in LAM-use patients with CHB. However, prior LAM use without refractoriness did not affect the development of ETV resistance. The serum hepatitis B virus DNA level at month 12 was a major predictor for the development of ETV resistance. Keywords: Chronic hepatitis B; Entecavir; Lamivudine; Resistance
Tamoxifen After Adjuvant Chemotherapy for Premenopausal Women With Lymph Node-Positive Breast Cancer: International Breast Cancer Study Group Trial 13-93
Authors: Marco Colleoni, Shari Gelber, Aron Goldhirsch, Stefan Aebi, Monica Castiglione-Gertsch, Karen N Price, Alan S Coates, Richard D Gelber
Journal: Journal of Clinical Oncology (2006)

Purpose The value of adjuvant tamoxifen after chemotherapy for premenopausal women with breast cancer has not been adequately assessed. Patients and Methods Between 1993 and 1999, International Breast Cancer Study Group Trial 13-93 enrolled 1,246 assessable premenopausal women with axillary node-positive, operable breast cancer. All patients received chemotherapy (cyclophosphamide plus either doxorubicin or epirubicin for four courses followed by immediate or delayed classical cyclophosphamide, methotrexate, and fluorouracil for three courses), which was followed by either tamoxifen (20 mg daily) for 5 years or no further treatment. The primary end point was disease-free survival (DFS). Tumors were classified as estrogen receptor (ER) -positive (n = 735, 59%) if immunohistochemical (IHC) or ligand-binding assays (LBA) were clearly positive. The ER-negative group included all other tumors (n = 511, 41%). A subset of the ER-negative group was defined as ER absent (n = 108, 9%) if IHC staining was none or if the LBA result was 0 fmol/mg cytosol protein. The median follow-up time was 7 years. Results Tamoxifen improved DFS in the ER-positive cohort (hazard ratio [HR] for tamoxifen v no tamoxifen = 0.59; 95% CI, 0.46 to 0.75; P &lt; .0001) but not in the ER-negative cohort (HR = 1.02; 95% CI, 0.77 to 1.35; P = .89). Tamoxifen had a detrimental effect on patients with ER-absent tumors compared with no tamoxifen in an unplanned exploratory analysis (HR = 2.10; 95% CI, 1.03 to 4.29; P = .04). Patients with ER-positive tumors who achieved chemotherapy-induced amenorrhea had a significantly improved outcome (HR for amenorrhea v no amenorrhea = 0.61; 95% CI, 0.44 to 0.86; P = .004), whether or not they received tamoxifen. Conclusion Tamoxifen after adjuvant chemotherapy significantly improved treatment outcome in premenopausal patients with endocrine-responsive disease, but its use as adjuvant therapy for patients with ER-negative tumors is not recommended.
Cluster analysis revealed differences on quality of life and susceptibility to exacerbation between subpopulations of smokers including COPD
Authors: Hiroki Hayashi, Takeo Ishii, Nariaki Kokuho, Misuzu Kurahara, Takashi Motegi, Kumiko Hattori, Kouichi Yamada, Koichiro Kamio, Akihiko Gemma, Kozui Kida
Journal: European Respiratory Journal (2011)

Background: It is necessary to categorize subpopulations of COPD or smokers by non-outcome phenotypes, such as emphysema without airflow obstruction.

Methods: 730 current- or ex-smokers including 382 COPD subjects were studied (66.7±11.0 yrs, 602male/128 females). We collected the data for all the subjects on pulmonary function test, 6 minute walking test (6MWT), body mass index (BMI), dysnpea (modified Medical Research Council (MMRC) Dyspnea Scale, Oxygen Cost Diagram (OCD)), and the extent of emphysema and airway disease assessed by chest computed tomography (CT) (low attenuation area (LAA)% and wall area (WA)%), and we also studied the data on the score of St. George's Respiratory Questionnaire (SGRQ) for QOL [n = 361], and exacerbations [n = 178]. We performed a principal component analysis (PCA) and cluster analysis by k-means method.

Results: PCA showed the major factors as follows: vital capacity (VC), LAA%, WA%, reversibility, PaO2, PaCO2, leg fatigue on 6MWT.

Cluster analysis with these factors classified the subjects into four clusters as follows: Cluster 1; 254 cases with mild emphysema (LAA% 22.1±10.8, WA% 45.0±14.1), Cluster 2; 156 cases with airway disease (LAA% 15.7±11.3, WA% 58.3±12.8), Cluster 3; 152 cases with emphysema and airway disease (LAA% 20.1±13.2, WA% 61.5±11.5), Cluster 4; 168 cases with severe emphysema (LAA% 41.0±11.8, WA% 57.0±11.3).

Cluster 4 has the highest SGRQ score (p < 0.0001). Cluster 2 and 4 were more prone to exacerbations (p < 0.01).

Conclusions: PCA and cluster analysis revealed that chest CT contributes to the classification to subpopulations in smoker with or without COPD.
Abstract MP41: Comparisons of Built Environment Characteristics Inside and Outside of Spatial Clusters of Physical Activity and Obesity in Older U.S. Women
Authors: Kosuke Tamura, Robin C Puett, Jaime E Hart, Heather A Starnes, Francine Laden, Philip J Troped
Journal: Circulation (2013)

Introduction: Spatial clustering methods have been applied to cancer for over a decade. These methods have been used in studies on physical activity (PA) and obesity. One recent study examined differences in built environment attributes inside and outside PA clusters. We tested two hypotheses: 1) PA and obesity would spatially cluster in older women; and 2) built environment attributes typically related to higher walkability would be found in high PA clusters, while attributes related to lower walkability would appear in high obesity clusters. Methods: We used data from 22,589 Nurses’ Health Study participants (mean age = 69.9 ± 6.8y) in California, Massachusetts, and Pennsylvania. Two outcomes were examined: meeting PA guidelines via self-reported walking (≥ 500 MET-min/week) and obesity (BMI ≥ 30.0). Objective built environment variables were created: population and intersection density, diversity of facilities, and facility density. We used a spatial scan statistic to detect clusters (i.e., areas with high or low rates) of the two outcomes. Built environment attributes were compared inside and outside clusters. Results: Six spatial clusters of PA were found in California and Massachusetts. Two obesity clusters were found in Pennsylvania. Overall there were significant differences (p&lt;0.05) in population and intersection density, and diversity and density of facilities inside and outside clusters. In some cases, built environment attributes related to higher walkability appeared in high PA clusters, while in other PA clusters we did not find this pattern. Differences in built environment attributes inside and outside obesity clusters showed inconsistent patterns. Conclusion: Although PA and obesity clusters emerged, the comparison of built environment attributes inside and outside clusters revealed a complex picture not fully consistent with existing literature. Further examination of PA and obesity clusters in older adults should include other built environment factors that may be related to these outcomes.
THE MEDICAL AND ECONOMIC ADVANTAGES OF ROENTGENOGRAPHIC CHEST SURVEY OF ALL HOSPITAL ADMISSIONS
Authors: Fred Jenner Hodges
Journal: Annals of Internal Medicine (1936)

Article1 June 1936THE MEDICAL AND ECONOMIC ADVANTAGES OF ROENTGENOGRAPHIC CHEST SURVEY OF ALL HOSPITAL ADMISSIONSFRED JENNER HODGES, M.D.FRED JENNER HODGES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-12-1639 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFew radiographic procedures lend themselves more readily to routine mass application than simple postero-anterior filming of the chest. Other than removal of clothing above the waist-line no advance preparation of the patient is necessary. Great speed without sacrifice of quality can be attained in handling patients because positioning is simple and exposure time is measured in split seconds. Photographic processing in volume offers no serious problem.Roentgenographic examination of the chest provides a wealth of detailed information concerning the thorax and its contents unrivaled by any other method of approach. The finished film serves furthermore as a valuable objective record... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Read before the Fifth General Session of the American College of Physicians, Detroit, March 4, 1936.From the Department of Roentgenology, University of Michigan, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Harvard Public-Health Chest ClinicUNITED STATES OF AMERICA 1 June 1936Volume 9, Issue 12Page: 1639-1657KeywordsThorax ePublished: 1 December 2008 Issue Published: 1 June 1936 PDF downloadLoading ...
Electrogram Characteristics in Postinfarction Ventricular Tachycardia
Authors: Frank Bogun, Subramaniam Krishnan, Mukarram Siddiqui, Eric Good, Joseph E. Marine, Claudio Schuger, Hakan Oral, Aman Chugh, Frank Pelosi, Fred Morady
Journal: Journal of the American College of Cardiology (2005)