tbuckley/cabot-search huggingface dataset:
Abstract 5901: Cardiac Expression of CCN1, Capable of Promoting Adhesion of CD34+ Progenitor Cells, Is Strongly Induced in Parvovirus B19-Associated Cardiomyopathy
Authors: Frank Wittchen, Uwe Kuehl, Lennart Suckau, Xiaomin Wang, Heinz-Peter Schultheiss, Wolfgang Poller
Journal: Circulation (2008)

The clinical phenotype of human dilated cardiomyopathy (DCM) encompasses a broad spectrum of etiologically distinct disorders. We obtained the cardiac expression profile of a DCM subtype (DCMi-B19) characterized by cardiac inflammation and parvovirus B19 (B19) persistence, to identify possible new therapeutic targets in humans. By microarray analysis and TaqMan PCR endomyocardial biopsies from DCMi-P19 patients (n=8) were compared to controls w/o cardiac disease. In DCMi-B19 an expression profile with dysbalance between several gene regulatory networks was observed. Tab. 1/2 classify deregulated genes in a group closely correlated (p&lt;0.01) with left ventricular ejection fraction (EF) and another one w/o correlation to EF. CCN1 was the most strongly upregulated of the EF-independent genes which encompass further members of the CCN1 regulatory network including CCN2=CTGF. In contrast the genes in tab. 2 are closely EF-correlated. We have previously shown that CCN1 is induced in endothelial cells by pro-inflammatory cytokines in vitro, which may also be the mechanism of its induction in human DCMi-B19 hearts. Two recent studies described the potential of CCN1 to promote migration/adhesion of CD34+ stem cells, and of activated monocytes via alphaMbeta2 integrin. This suggests that the CCN1 induction in DCMi-B19 may influence the influx of CD34+ stem cells and activated monocytes to the inflamed heart, and obviously this may occur independent of hemodynamic impairment. B19 viruses infect cardiac microvascular endothelium, and endothelial CCN1 induction may therefore be involved in disease pathogenesis by altering circulating cell interactions with the inflamed heart. Table 1: EF-Independent Gene Deregulation Table 2: EF-Correlated Gene Deregulation
Abstract 19007: Defibrillator Therapy in Coronary Artery Disease and Idiopathic Dilated Cardiomyopathy. Is There Really a Difference? A Real Life Single Center Experience in 778 Patients.
Authors: Juergen Kuschyk, Florian Streitner, Antonina Schoene, Christian G Veltmann, Rainer Schimpf, Martin Borggrefe
Journal: Circulation (2010)

Methods: 778 consecutive patients with either IHD (n=555) or IDC (n=223) were implanted with an Implantable Cardioverter Defibrillator (ICD) and followed for a mean period of 34 months. Results: The proportion of males was significantly higher in both groups (IHD 85% vs. IDC 75%, p<0.05). Patients with coronary artery disease were significantly older (70 +/− 10 years vs. 66 +/− 12 years, p<0.05). The mean ejection fraction was 33 +/−11% in IHD and 28 +/− 10% in IDC patients (p<0.05). Indication for ICD implantation was primary prophylaxis in 445 (80%) patients with IHD and 201 (90%) patients with IDC. The mean time to the first spontaneous ventricular tachyarrhythmia (ventricular tachycardia or ventricular fibrillation, VT/VF) was 17 months in patients with IHD and 21 months in patients IDC (ns). Spontaneous VT/VF episodes occurred in 28% of patients with IHD and 30% of patients with IDC (p=ns), with a mean number of 21 vs. 22 episodes per patient, respectively. The episodes consisted in VT in 24% of IHD ...
Radionuclide imaging of the heart
Authors: N. Tamaki, A. J. Fischman, H. William Strauss
Journal: Clinical Nuclear Medicine (1991)

Approximately 43 million Americans have one or more forms of acquired heart or blood vessel disease: high blood pressure occurs in 38 million adults; coronary artery disease occurs in 4.5 million adults; rheumatic heart disease occurs in 2 million; and stroke in 1.9 million. Myocardial infarction caused approximately 555000 deaths (25% of all mortality) in 1982. Some aspect of the pathophysiology of each of these diseases can be evaluated with radionuclide techniques.
Local research ethics committees
Authors: P V Scott, C A Pinnock, P. G Stone, C. E Blogg
Journal: BMJ (1997)

<h3>OBJECTIVE</h3> To evaluate the prevalence of diastolic dysfunction in patients with anticardiolipin antibodies (aCL) and to examine whether the antiphospholipid syndrome (APS) is associated with diastolic dysfunction independently of valvular abnormalities and systolic dysfunction. <h3>METHODS</h3> Pulsed, continuous, colour Doppler echocardiography was performed in 179 subjects, of whom 15 were excluded from the analysis because of systolic dysfunction or severe valvular disease. The remaining 164 subjects included 29 patients with primary APS, 26 patients with secondary APS (APS in the presence of systemic lupus erythematosus (SLE)), and 30 patients with SLE and aCL but without APS; 43 patients with SLE without aCL and 36 normal volunteers served as control groups. <h3>RESULTS</h3> The groups compared differed significantly in all measures of right ventricular function. There was a gradation of increasing diastolic function impairment as manifested by prolonged deceleration time (DT) and isovolumic relaxation time (IVRT) across the groups of patients with SLE without aCL, SLE with aCL, secondary APS, and primary APS. Differences in left ventricular diastolic function measures were less prominent. In regression analysis, DT increased by 19.6 ms (p=0.002) in the presence of primary APS and by 20.1 ms (p=0.038) in the presence of pulmonary hypertension. The titre of IgG aCL was the strongest predictor of a prolonged IVRT. <h3>CONCLUSION</h3> Diastolic dysfunction, in particular of the right ventricle—that is, independent of valvular disease and systolic dysfunction, is a prominent feature of APS and may be related to the pathogenesis of the syndrome.
Disturbances of thirst and water homeostasis in patients with affective illness
Authors: G S Zubenko, R I Altesman, J W Cassidy, P J Barreira
Journal: American Journal of Psychiatry (1984)

Three patients with recurrent affective disorders experienced polydipsia and the syndrome of inappropriate secretion of antidiuretic hormone in association with acute exacerbations of their affective disorders. These disturbances of water homeostasis responded to treatment of the affective disorders.
Abstract 15743: The Clinical Syntax Score Is A Predictor Of 5-year Clinical Outcomes After Sirolimus-eluting Stents Implantation Amongst All-comers Population
Authors: Hironori Hara, Jiro Aoki, Takuya Hashimoto, Kazuyuki Yahagi, Laurence C Lee, Makoto Nakashima, Yoshifumi Nakajima, Satoru Kishi, Masanori Taniwaki, Sen Yachi, Shuzou Tanimoto, Kengo Tanabe, Hiroyoshi Nakajima, Kazuhiro Hara
Journal: Circulation (2011)

Purpose: The SYNTAX score is able to stratify risk amongst a real world population treated with drug-eluting stents. However, the SYNTAX score is based on only lesion-based scoring system. The Clin...
Senior nurses are out of touch
Authors: E. Cummins, J. S Stern
Journal: BMJ (1995)

EDITOR,--Jane Salvage's attempts to examine what is happening to nursing is notable for its rejection of the past.1 The contributions of Jacqueline Short (a nurse who became a doctor) and Ann Bradshaw (a lecturer in nursing), both with a different view,2 are said to show shaky reasoning and nostalgia for a mythical golden age.1 M Barton3 rejects Hay's assertion4 that the nursing leadership is “frog-marching” nursing towards clinical autonomy (and research) against the wishes of the “rank and …
Abstract 5326: SIRT1-Dependent and -Independent Effects of Resveratrol on Cardiovascular Oxidative Stress
Authors: Ning Xia, Andreas Daiber, Alice Habermeier, Gerrit Spanier, Qing Lu, Matthias Oelze, Ellen I Closs, Thomas Munzel, Ulrich Forstermann, Huige Li
Journal: Circulation (2009)

SIRT1 is a NAD+-dependent class III histone deacetylase. Recent studies point to SIRT1 as a key regulator of angiogenesis, vascular tone and endothelial function. The aim of the present study was to investigate the role of SIRT1 in regulating oxidative stress in the cardiovascular system. Atherosclerotic apolipoprotein E knockout (ApoE-KO) mice were treated with a SIRT1 activator, resveratrol (30 or 100 mg/kg/day for 7 days via gavage). Resveratrol treatment significantly reduced the levels of 3-nitrotyrosine, malondialdehyde and superoxide in the heart, which was associated with an upregulation of superoxide dismutase isoforms (SOD1–3), glutathione peroxidase 1 (GPx1), and catalase. In parallel, mRNA expression of NADPH oxidase subunits NOX2 and NOX4 was reduced. Resveratrol also inhibited the translocation of p47phox and Rac1 and decreased the activity of NADPH oxidase complex in heart membrane fraction. The cofactor of endothelial nitric oxide synthase (eNOS), (6R)-5,6,7,8-tetrahydro-L-biopterin (BH4), is synthesized from GTP via a de novo pathway by the rate-limiting enzyme GTP cyclohydrolase I (GCH1), and essential for eNOS functionality. ApoE-KO mice showed increased oxidative stress and eNOS-mediated superoxide production (i.e. eNOS uncoupling). Treatment of ApoE-KO mice with resveratrol enhanced the expression of GCH1 and increased the cardiac levels of BH4. This was associated with reduced superoxide production from eNOS. To find out whether the observed effects of resveratrol were SIRT-dependent, human endothelial EA.hy 926 cells were treated with resveratrol. Also in these cells, resveratrol treatment led to an upregulation of SOD1–3, GPx1, catalase, GCH1, and a downregulation of NOX4. SIRT1 inhibition with sirtinol or SIRT1 knockdown by siRNA reduced the effects of resveratrol on SOD1, SOD2, GPx1, GCH1, but not those on SOD3, catalase, or NOX4. These data indicate that resveratrol reduces cardiovascular oxidative stress by decreasing superoxide production from NADPH oxidases and uncoupled eNOS, and by enhancing superoxide inactivation by SOD isoforms and catalase. Part of the resveratrol effects are SIRT1-dependent. Thus, SIRT1 is likely a novel target for treatment of cardiovascular disease.
Abstract 2409: Parvovirus B19 and Cardiomyopathy - The New Coxsackievirus
Authors: Garrick C Stewart, Myra A Lipes, Mary Susan Anello, Parakash P Pratibhu, Raju Gottumukkala, Gayle L Winters, Jeffrey A Towbin, Kenneth L Baughman
Journal: Circulation (2008)

Enteroviruses such as coxsackievirus have been long considered a common cause of viral myocarditis. More recently multiple cardiotropic viruses have been isolated from endomyocardial biopsies (EMBx) from patients with myocarditis and idiopathic ventricular dysfunction. To determine the prevalence of viral genomic material in EMBx from adult heart failure patients. EMBx were obtained from 100 consecutive patients (median ejection fraction 20%, range 15– 65%) presenting for cardiomyopathy evaluation (median duration of symptoms 6mos, range 2d-20yrs). Frozen EMBx were evaluated using PCR and RT-PCR for cardiotropic viruses using primers specific for adenovirus, cytomegalovirus, enteroviruses, Epstein-Barr virus, and parvovirus B19 (PVB19). Positive human DNA/RNA controls were performed. Formalin preserved EMBx were evaluated by light microscopy for the presence of myocarditis. PVB19 was the only cardiotropic virus isolated from EMBx tissue (n = 12). Viral sequencing revealed different strains of PVB19 in each subject. No PVB19 positive subject had anti-parvovirus IgM, but all had circulating IgG, suggesting chronic infection. No subject with a PVB19 positive EMBx had evidence of active or borderline myocarditis according to the Dallas criteria. There were no differences in the degree of myocyte hypertrophy or fibrosis in PVB19 positive versus negative EMBx. PVB19, a single-stranded DNA virus and common childhood infection, was the only virus isolated from EMBx samples in this series of adult heart failure patients from the United States. The relationship between between PVB19 viral persistence and the development of cardiomyopathy merits further study.
Abstract 17145: Ventricular-Specific Deletion of Liver Kinase B1 Fails to Produce Cardiomyopathy and Atrial Fibrillation Associated with Pan-Cardiac Deletion of Liver Kinase B1
Authors: Jenna L Ross, Monica Palmeri, Vlad G Zaha, Lawrence H Young
Journal: Circulation (2011)

Liver kinase B1 (LKB1) is a serine/threonine kinase that is the major upstream kinase for AMP-activated protein kinase, but also appears to have additional actions regulating cardiac growth and development. In order to assess the functional consequences of LKB1 deletion on ventricular structure and function, we compared pan-cardiac LKB1 knockout (MHC Cre-LKB1flox/flox) with ventricular-specific LKB1 knockout (MLC2v Cre-LKB1flox/flox) and control mice (LKB1flox/flox). LKB1 mRNA was reduced by 91% in MHC Cre-LKB1flox/flox ventricles and 84% in MLC2v Cre-LKB1flox/flox ventricles; LKB1 protein was reduced by 95% in both RV and LV from MHC Cre-LKB1flox/flox mice and by 87% in MLC2v Cre-LKB1flox/flox mice. LKB1 expression in left atrial (LA) was normal in MLC2v Cre-LKB1flox/flox, but was reduced by 85% in MHC Cre-LKB1flox/flox. MHC Cre- LKB1flox/flox mice developed early onset atrial fibrillation (2 weeks) in contrast to MLC2v Cre-LKB1flox/flox and control hearts, which showed no arrhythmia. MHC Cre-LKB1flox/flox hearts had LA enlargement vs. MLC2v Cre-LKB1flox/flox vs. LKB1flox/flox (2.53±0.13 mm vs. 1.59±0.21 mm vs.1.61±0.12 mm, n=5-11, p&lt;0.05). In addition, left ventricular (LV) wall thickness was greater (p&lt;0.05) in MHC Cre-LKB1flox/flox (0.91±0.03 mm) vs. MLC2v Cre-LKB1flox/flox (0.71±0.02 mm) vs. LKB1flox/flox (0.69±0.02 mm, p&lt;0.05). MHC Cre-LKB1flox/flox also had decreased LV ejection fraction (LVEF) of 30.9±1.5% vs. MLC2v Cre-LKB1flox/flox (48.5±2.7%) vs. LKB1flox/flox (46.8±3.1%, p&lt;0.05). Electron micrographs of MHC Cre-LKB1flox/flox ventricles showed alterations in gap junction formation and a loss of mitochondrial integrity; however, both MHC Cre-LKB1flox/flox and MLC2v Cre-LKB1flox/flox hearts appeared normal. Thus, pan-cardiac deletion of LKB1 leads to atrial fibrillation, LV hypertrophy and LV dysfunction, which do not occur with ventricular specific LKB1 deletion.
Adolescent mental health and risky sexual behaviour
Authors: D. L Bennett
Journal: BMJ (2000)

<h3>Objective:</h3> To describe the neurologic and neuroradiologic complications of Shiga toxin producing Escherichia coli infection (STEC)–associated hemolytic-uremic syndrome (HUS) in adults. <h3>Methods:</h3> All 52 adult patients with STEC O104:H4 infection cared for at Hannover Medical School during the outbreak in Germany through May–July 2011 are considered in this observational study. Forty-three of the 52 patients underwent a standard neurologic diagnostic procedure including clinical examination, Mini-Mental State Examination, and Glasgow Coma Scale Score. Thirty-six patients underwent EEG, and 26 had cerebral MRI, 9 of them repeatedly. Case records of 9 patients who had not been seen by a neurologist were analyzed retrospectively. <h3>Results:</h3> Forty-eight of the 52 patients had HUS. All but 1 of these showed neurologic symptoms. Focal neurologic signs like double vision, difficulties in finding words, or hyperreflexia were present in 23, additional deficits in orientation, attention, memory, or constructive abilities in 9, and marked impairment of consciousness in 15. MRI showed brainstem, midbrain, thalamus, corpus callosum, and white matter lesions in half of the patients, predominantly in diffusion-weighted images. The extent of MRI lesions did not correlate with clinical symptoms. General slowing but no focal alteration was found in half of the patients examined by EEG. <h3>Conclusion:</h3> Our findings suggest a toxic-metabolic pathology behind the neurologic impairment instead of multiple infarction due to microthrombosis. Future studies should aim to clarify if early antibiotic therapy or bowel cleansing might help to decrease the rate of neurologic complications in STEC-HUS.
A test of the transmethylation hypothesis in acute schizophrenic patients
Authors: W T Carpenter, E B Fink, N Narasimhachari, H E Himwich
Journal: American Journal of Psychiatry (1975)

Keeping biochemical determinations and clinical judgements independent, the authors investigated three aspects of the transmethylation hypothesis. They found that 26 acutely schizophrenic patients were no more likely to have bufotenine or N,N-dimethyltryptamine present in urine or elevated serum indolethylamine N-methyltransferase activity than 10 normal control subjects. The authors conclude that these are naturally occurring substances which are equally likely to be present in normal and schizophrenic subjects.
A review of 32 cases of tardive dystonia
Authors: J D Wojcik, W E Falk, J S Fink, J O Cole, A J Gelenberg
Journal: American Journal of Psychiatry (1991)

Tardive dystonia, historically combined with tardive dyskinesia, is now viewed as probably having a different pathophysiology, course, outcome, and treatment response than tardive dyskinesia. In addition, patients with tardive dystonia are reported to be younger, and most are men. This study evaluates characteristics of 32 patients with tardive dystonia and compares results to other reports.Twenty-four patients had been referred for research purposes and were videotaped, while eight had been followed clinically. Two of the authors reviewed all available videotapes and clinical reports to assess the course of symptoms over time. For global ratings and ratings of affected body parts, two scales were used: the Abnormal Involuntary Movement Scale (AIMS) for tardive dyskinesia and a similar scale for tardive dystonia. The method of case finding does not provide incidence or prevalence data for tardive dystonia.Fifty-nine percent of the patients experienced onset of tardive dystonia symptoms within 6 years of antipsychotic drug exposure; women had a shorter exposure time. No patient had complete remission of tardive dystonia symptoms, and 22 were moderately or severely impaired when their movements were most prominent.While epidemiological studies of tardive dystonia have yet to be performed, these results support the observations of others that most patients with tardive dystonia are men, have a short history of exposure to antipsychotic drugs, and may initially present with blepharospasm. Tardive dystonia rarely remits completely, can cause notable disability, and may partially respond to anticholinergic agents.
Abstract 153: Co-commitment and Interplay between Akt and AMPK in the Regulation of Endothelial NO Synthase Phosphorylation by Reactive Oxygen Species
Authors: Zhuangli Hu, Yong Xia
Journal: Circulation (2006)

Reactive oxygen species critically modulates eNOS function via affecting eNOS phosphoryla-tion. With serum-starved cells, hydrogen peroxide (H2O2) was reported to induce eNOS Ser 1179/1177 (bovine/...
Abstract 12062: Incidence of Silent Cerebral Lesions After Pulmonary Vein Isolation Using a Remote Robotic Navigation Sytem as Compared to Manual Ablation
Authors: Andreas Rillig, Udo Meyerfeldt, Roland Tilz, Jochen Talazko, Vlada Zvereva, Ralf Birkemeyer, Tomislav Miljak, Peter Wohlmuth, Ulrich Fink, Werner Jung
Journal: Circulation (2011)

Background The incidence of silent cerebral lesions (SCL) after atrial fibrillation ablation is highly variable depending on technologies used. The incidence of periprocedural SCL following robotic...
External cephalic version at term should be considered
Authors: P S Bhal, K Asaad, A Sharma, R W Shaw
Journal: BMJ (1996)

EDITOR,—P J Danielian and colleagues report a 20% rate of long term disability among fetuses delivered by the breech, irrespective of mode of delivery.1 This raises the key issue of whether there is an inherent abnormality associated with such fetuses. Braun et al initially suggested that fetuses with a wide range of morphological and functional damage more commonly present by the …
Abstract 19608: Public Report Cards Associated With Decreased Heart Failure Readmissions in the Effect Study
Authors: Jack V Tu, Nicole K Boom, Dennis T Ko, Linda Donovan, Peter C Austin, David Alter, Douglas S Lee
Journal: Circulation (2010)

Background: Public reporting of hospital performance on in-hospital heart failure (HF) quality indicators is increasingly common although its effectiveness in reducing HF readmissions is uncertain. We conducted an analysis of data from the Enhanced Feedback for Effective Cardiac Treatment (EFFECT) (clinicaltrials.gov NCT00187460) cluster randomized trial of cardiac report cards to evaluate the hypothesis that public reporting of hospital performance might be associated with reduced HF readmission rates. Methods: Patients included in this post-hoc analysis (n=7,399) were those hospitalized for an index episode of HF identified as part of the follow-up cohort in the EFFECT study, conducted in Ontario, Canada. Participating Ontario hospital corporations (n=86) were randomized to early (January 2004) or delayed feedback (September 2005) of a report card on their baseline performance (1999 to 2001) on a set of 6 process-of-care indicators for HF. Follow-up data were collected between April 2004 and March 2005....
Epiglottitis and Laryngotracheobronchitis
Authors: W D Clark, B J Bailey, T J Clegg
Journal: BMJ (1953)

Epiglottis and laryngotracheobronchitis are potentially life-threatening infections in the pediatric population. Unlike epiglottitis, laryngotracheobronchitis is very common. While both diseases may present with stridor and signs of respiratory obstruction, it is important to distinguish between them because the management strategies differ. Laryngotracheobronchitis usually responds to humidification. Epiglottitis requires an artificial airway and intensive antibiotics. The use of steroids remains controversial.
Abstract 15300: Cardiac I-123 Metaiodobenzylguanidine Imaging Improves the Prognostic Power of 6-Minute Walk Test in Patients With Chronic Heart Failure: a Long-Term Follow-Up Study
Authors: Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Koji Tanaka, Yusuke Iwasaki, Masato Kawasaki, Yuki Kuramoto, Takashi Naito, Tadao Fujimoto, Kentaro Ozu, Takumi Kondou, Kaoruko Sengoku, Hironori Yamamoto, Masatake Fukunami
Journal: Circulation (2011)

Background: The 6-minute walk test (6MWT) is an established prognostic tool in patients with chronic heart failure (CHF). In addition, cardiac I-123 metaiodobenzylguanidine (MIBG) imaging also prov...
Abstract 20870: Insulin Induces the Release of Endothelial Barrier Stabilizing Factor From Platelets by a Nitric Oxide-G Kinase-Dependent Pathway
Authors: Muhammad Aslam, Johannes Thom, Imran Hussain, Daniel Sedding, Muhammad Arshad, Frauke V Härtel, Thomas Noll, Hans Michael Piper, Dursun Gündüz
Journal: Circulation (2010)

Introduction: Recent findings suggest that besides its metabolic effects, insulin also modulates the cardiovascular functions. Recently, it has been shown by us and others that insulin also acts as...