tbuckley/cabot-search huggingface dataset:
Abstract P059: Analytic Variability of the Glucose Test: A Comparison among Different Specimens and Anticoagulants
Authors: Chiara Donfrancesco, Amalia De Curtis, Licia Iacoviello, Cinzia Lo Noce, Luigi Palmieri, Serena Vannucchi, Simona Giampaoli
Journal: Circulation (2013)

Background: There is a marked variability (both biologic and analytic) involved in glucose testing. Even though biological variability is substantially greater than the analytic, a variability in the measurement of glucose is introduced by the manner in which the blood sample is collected and handled before its arrival to the laboratory. While plasma is recommended as the preferred specimen, some clinicians might be using results obtained on serum specimens. This study aimed to assess systematic difference in the glucose test results using different specimens and anticoagulants. Methods: Blood samples from 84 men and 101 women 25-64 years old involved in the Italian Health Examination Survey/Osservatorio Epidemiologico Cardiovascolare (HES/OEC) were used. Fasting glucose test was assessed using serum and plasma by the addition of fluoride or EDTA to the blood collection tube. Biochemical tests were assayed in a unique laboratory. Comparison among mean values were assessed using t-test for paired sample. R...
Abstract 8727: Baseline Functional Status and the Benefit of Cardiac Resynchronization Therapy in Patients with Mildly Symptomatic Heart failure Enrolled in MADIT-CRT
Authors: Andrew Brenyo, Alon Barsheshet, Mohan Rao, Wojciech Zareba, Arthur Moss, Ilan Goldenberg
Journal: Circulation (2011)

Background: The MADIT-CRT trial showed that cardiac resynchronization therapy with a defibrillator (CRT-D) is associated with a significant reduction in the risk of heart failure (HF) or death in mildly symptomatic patients with left ventricular dysfunction. The aim of the present study was to relate the clinical benefit of CRT-D therapy to baseline functional status, as determined by the 6 minute walk test (6MWT), and to assess the effect of the device on functional status at 1-year in the MADIT-CRT population. Methods: Multivariate Cox proportional hazards regression modeling was used to assess the effect of CRT-D vs. defibrillator-only therapy on the risk of HF or death and the separate occurrence of all-cause mortality by baseline functional status (dichotomized at the median value of the baseline 6MWT [350 m]) among 1765 patients enrolled in MADIT-CRT. Results: A lower functional status (6MWT &lt;350m) was associated with a 73% (p &lt; 0.001) increase in the risk of HF or death and a 2.4-fold increase in all-cause mortality among patients treated with defibrillator-only therapy. After multivariate adjustment for relevant covariates CRT-D therapy was associated with a significant 48% (p=0.01) reduction in the risk of all-cause mortality among study patients with a lower functional status who had LBBB at enrollment (Fig.1A), whereas treatment with the device was not associated with a significant survival benefit among study patients with a higher function status (6MWT ≥350m) with LBBB (Fig. 1B). At 1-year of follow-up, improvement in 6MWT was observed in a similar proportion of CRT-D patients (50.2%) and defibrillator-only patients (50.7%) p = 0.84. Conclusions: A low baseline functional status is a powerful predictor of HF or death among mildly symptomatic HF patients and identifies patients in this population who derive a significant survival benefit from cardiac resynchronization therapy.
Abstract 344: Massive Transfusion Prediction Scores Can Also Predict Early Traumatic Coagulopathy
Authors: Takayuki Ogura, Minoru Nakano, Mitsunobu Nakamura, Kenji Fujizuka
Journal: Circulation (2014)

BACK GROUND: The aggressive administration of plasma has been recommended for the improvement of traumatic coagulopathy. The survival benefit has been found in trauma resuscitation with rich plasma, and this benefit seems to be related to early use of this blood product. However, to our knowledge, no method for the recognition or prediction of traumatic cougulopathy at the point of a patient’s arrival has been established. The aim of this study was to test the predictive value of massive transfusion prediction scores for early traumatic coagulopathy. METHOD: We reviewed records of severe trauma patients admitted to our center from Jan. 2008 to Mar. 2014, whose Injury Severity Score was 16 or more. Traumatic Bleeding Severity Score (TBSS), Trauma Associated Severe Hemorrhage Score (TASH Score), and Assessment of Blood Consumption Score (ABC Score) were calculated. Early traumatic coagulopathy was defined as 150mg/dl or less of fibrinogen and 1.5 or more of PT-INR within 6 hours from injury, although transfusion and crystalloid infusion was provider dependent. Cardiopulmonary arrest patients on arrival and simple head or spine trauma patients were excluded. Each predictive value for early traumatic coagilopathy was tested by area under the receiver operating characteristic curve (AUC). Receiver operating characteristic curve comparison was performed to compare the accuracy between TBSS, TASH Score, and ABC Score. Each spearman’s rank correlation coefficient for the amount of fresh frozen plasma transfused within 24 hours form injury was checked. RESULT: 388 patients were enrolled in this study. The AUC of TBSS (0.927) was significantly higher than that of TASH Score (0.856) or ABC Score (0.726) (both Bonferoni adjusted p&lt;0.01). Each Spearman’s rank correlation coefficient for the amount of fresh frozen plasma was 0.732 (TBSS, p&lt;0.01), 0.658 (TASH Score, p&lt;0.01), and 0.471 (ABC Score, p&lt;0.01). Conclusion: Massive transfusion prediction scores can also predict the early traumatic coagulopathy. TBSS had the highest predictive value and strong correlation between the score and the needed plasma. The calculation of TBSS is simple. Therefore, TBSS will rapidly predict the need for rich plasma transfusion.
Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study
Authors: K S Kendler, M C Neale, D Walsh
Journal: American Journal of Psychiatry (1995)

The authors sought to evaluate whether the pattern of schizophrenia and related disorders in probands and their relatives can be explained by a single underlying continuum of liability to the "schizophrenia spectrum."In the epidemiologically based Roscommon Family Study, the authors separately examined--in siblings, parents, and relatives of index and comparison probands--the familial aggregation and coaggregation of five hierarchically defined disorders: schizophrenia, schizoaffective disorder, schizotypal/paranoid personality disorder, other nonaffective psychoses, and psychotic affective illness. A multiple threshold model was fitted to these contingency tables by maximum likelihood.The multiple threshold model that constrained resemblance to be the same in siblings and parents fit the data well and estimated the correlation in liability to schizophrenia spectrum disorders between probands and first-degree relatives at 0.36. Parents, however, required higher levels of liability to manifest schizophrenia spectrum disorders than siblings. While schizophrenia and psychotic affective illness could be clearly assigned to the two extremes of the schizophrenia spectrum, the proper ordering of schizoaffective disorder, schizotypal/paranoid personality disorder, and other nonaffective psychoses could not be unambiguously determined.These results are consistent with the existence of a schizophrenia spectrum in which these five disorders are manifestations, of varying severity, of the same underlying vulnerability. This vulnerability is strongly transmitted within families.
Effect of Eculizumab on Physician-Reported Symptoms in the Russian Cohort of the Paroxysmal Nocturnal Hemoglobinuria (PNH) International Registry
Authors: Igor Lisukov, Alexander Kulagin, Alexey Maschan, Elena Shilova, Kudrat Abdulkadyrov, Andrey Zaritskiy, Valentina Ivanova, Yulia Bogdanova, Svetlana Volkova, Andrey Gavrilenko, Tatyana Kaporskaya, Sergey Meresiy, Tatyana Schneider, Svetlana Yakupova, Ludmila Anchukova, Bulat Bakirov, Natalia Kosacheva, Tatiana Krinitsina, Viktoria Ustyantseva, Yuriy Shatokhin, Elena Vinogradova, Tatiana Kazankova, Alexander Rumyantsev, Boris Afanasyev
Journal: Blood (2014)
Lithium and tryptophan augmentation in clomipramine-resistant obsessive- compulsive disorder
Authors: S A Rasmussen
Journal: American Journal of Psychiatry (1984)

Obsessive-compulsive patients with symptoms resistant to clomipramine were treated by lithium or L-tryptophan augmentation. The improvement noted supports the hypothesis that increasing serotonergic neurotransmission ameliorates obsessive symptoms.
Novel Pathogenic Defects Of Dead/H-Box Helicases In Myeloid Neoplasms
Authors: Chantana Polprasert, Mikkael A. Sekeres, Hideki Makishima, Bartlomiej P Przychodzen, Naoko Hosono, Richard A Padgett, Jarnail Singh, Otrock Zaher, Sudipto Mukherjee, Manuel G. Afable, Holleh D Husseinzadeh, Sarah Mcmahon, Wenyi Shen, Dayong Huang, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Jaroslaw P. Maciejewski
Journal: Blood (2013)
Abstract 13718: Association Between Serum Fabp4 Levels, Pericardial Adipose Tissue Volume, and Plaque Characteristics in Patients With Type 2 Diabetes Mellitus
Authors: Takehiro Nakahara, Keiko Kawai-Kowase, Rieko Nakahara, Toshihiro Utsugi, Tatsuya Iso, Masashi Arai, Shoichi Tomono, Yoshito Tsushima, Masami Murakami, Masahiko Kurabayashi
Journal: Circulation (2013)

Introduction:  Fatty acid binding protein 4 (FABP4), a cytosolic FA chaperone abundantly expressed in adipocytes and macrophages, has been implicated in the development of atherosclerosis in metabolic disease. Pericardial adipose tissue (PAT) may play a role in coronary atherosclerosis. In this study, we examine the association between serum FABP4 levels, PAT, and several surrogate markers for plaque vulnerability (positive remodeling (PR), spotty calcification, and low attenuation) in patients with type 2 diabetes.   Material and methods:  We enrolled 60 consecutive patients with type 2 diabetes who underwent cardiac CT scanning for evaluation of coronary artery disease at Gunma University hospital. Coronary stenosis, PAT volumes (cm 3 ), and spotty calcification were examined on an offline workstation. Serum levels of FABP4, leptin, adiponectin, iInterleukin-6, TNF-alpha, advanced glycation endproducts (AGE) and receptor of AGE (RAGE) were measured by enzyme-linked immunosorbent assay (ELISA). HbA1c, glucose, HDL-cholesterol, LDL-cholesteriol, triglyceride, B-type natriuretic peptide were measured in the institutional laboratory.   Results:  Circulating FABP4 but not other biomarkers (leptin, adiponectin, iInterleukin-6, TNF-alpha, AGE and RAGE) were positively correlated with PAT volume (R=0.576, P   Conclusion:  Increased circulating FABP4 are positively associated with PAT volume and the presence of low attenuation plaques while they are inversely associated with PR in patients with type 2 diabetes. These findings suggest that therapeutic intervention aimed at lowering serum FABP4 levels may represent the potentially interesting approach to the stabilization of the plaques without causing negative remodeling in type 2 diabetic patients.
On the Pathogenesis of Syringomyelia: A Review
Authors: Bernard Williams
Journal: Journal of the Royal Society of Medicine (1980)

Discussion of the pathogenesis of syringomyelia involves considering the origin of the fluid and also the forces which cause that fluid to break down the structure of the cord. When cerebrospinal fluid (CSF) appears to be the destructive element, it commonly enters through a patent central canal running from the fourth ventricle to the inside of the syrinx. In both clinical and experimental situations pressure differences may be measured which suck on the hindbrain, particularly the cerebellar tonsils, producing deformities. These pressure differences may also suck fluid into the syrinx. In other cases, even when a communication does not appear to be patent, the hindbrain abnormalities are usually present and suck effect may usually be demonstrated and its correction be accompanied by clinical improvement. Other sources of fluid within a syrinx include liquefaction of haematomata after traumatic paraplegia and transudation of fluid from intrinsic spinal tumours. Once fluid is present within a cord cavity it may pulsate upwards and downwards in response to fluid movements in the subarachnoid space, the most energetic of which result from venous influences. Such movement, ‘slosh’, may cause the cavities to extend at either end giving rise to upward and downward extension from a post-traumatic cord cyst and sometimes to syringobulbia. Cord ischaemia, venous congestion and transport of fluid along perivascular spaces may all play a part in the maintainance of cord cavities or the progression of the clinical disabilities.
Correlating Bladder Cancer Risk Genes with Their Targeting MicroRNAs Using MMiRNA-Tar
Authors: Yang Liu, Steve Baker, Hui Jiang, Gary Stuart, Yongsheng Bai
Journal: Genomics Proteomics & Bioinformatics (2015)

Abstract The Cancer Genome Atlas (TCGA) (http://cancergenome.nih.gov) is a valuable data resource focused on an increasing number of well-characterized cancer genomes. In part, TCGA provides detailed information about cancer-dependent gene expression changes, including changes in the expression of transcription-regulating microRNAs. We developed a web interface tool MMiRNA-Tar (http://bioinf1.indstate.edu/MMiRNA-Tar) that can calculate and plot the correlation of expression for mRNA−microRNA pairs across samples or over a time course for a list of pairs under different prediction confidence cutoff criteria. Prediction confidence was established by requiring that the proposed mRNA−microRNA pair appears in at least one of three target prediction databases: TargetProfiler, TargetScan, or miRanda. We have tested our MMiRNA-Tar tool through analyzing 53 tumor and 11 normal samples of bladder urothelial carcinoma (BLCA) datasets obtained from TCGA and identified 204 microRNAs. These microRNAs were correlated with the mRNAs of five previously-reported bladder cancer risk genes and these selected pairs exhibited correlations in opposite direction between the tumor and normal samples based on the customized cutoff criterion of prediction. Furthermore, we have identified additional 496 genes (830 pairs) potentially targeted by 79 significant microRNAs out of 204 using three cutoff criteria, i.e., false discovery rate (FDR) &amp;lt; 0.1, opposite correlation coefficient between the tumor and normal samples, and predicted by at least one of three target prediction databases. Therefore, MMiRNA-Tar provides researchers a convenient tool to visualize the co-relationship between microRNAs and mRNAs and to predict their targeting relationship. We believe that correlating expression profiles for microRNAs and mRNAs offers a complementary approach for elucidating their interactions.
Abstract 12392: Describing Burden of Atrial Fibrillation Using a Patient-Level National Survey
Authors: Winnie W Nelson, Sarah A White, Jan-Samuel Wagner, Marco da Costa DiBonaventura
Journal: Circulation (2010)

Objective and Methods:  The 2009 National Health and Wellness Survey is a patient-reported, internet-based questionnaire administered to a nationwide sample of adults (n=75,000) stratified by age, gender, and race. Primary objective: to assess the burden of illness associated with atrial fibrillation (AF) and certain AF medication combinations. Regression analyses compared patients diagnosed with AF (n=1279) with all patients not diagnosed with AF.   Results:  The data indicated that among the total US adult population surveyed, 2% reported experiencing AF, 70% of whom were on prescription therapy. Patients with AF were more often male, Caucasian, ≥65 years of age, on Medicare, and retired. In the previous 6 months, they were significantly more likely to have contacted a healthcare provider or to have visited an emergency room ( p  p    Conclusions:  AF continues to impose a significant burden for both patients and healthcare utilization. Improved adherence to guidelines could potentially reduce the burden of AF, which might also be expected to improve clinical outcomes.
Abstract 2426: The Impact of Depressive Symptoms on Survival in Patients with Heart Failure is Altered by Body Mass Index
Authors: Rebecca L Dekker, Debra K Moser, Misook L Chung, Seongkum Heo, Terry A Lennie
Journal: Circulation (2007)

Background: Depressive symptoms predict shorter event-free survival in patients with heart failure (HF). Increased body mass index (BMI) is associated with longer event-free survival in patients wi...
Abstract 2463: Hypercapnic Resuscitation Mitigates Post-resuscitation Left Ventricular Systolic and Diastolic Dysfunction by Ameliorating Myocardial Necrosis and Apoptosis
Authors: Wei-Tien Chang, Lay-San Gan, Chiang-Ting Chien, Chun-Pei Lee, Ming-Fang Wu, Chien-Hua Huang, Chiung-Yuan Hsu, Min-Shan Tsai, Hsiao-Ju Cheng, Shyr-Chyr Chen, Yuan-Teh Lee, Wen-Jone Chen
Journal: Circulation (2009)

Background: Myocardial dysfunction is usually encountered in the early post-resuscitation phase and can lead to circulatory failure and early mortality. Hypercapnic reperfusion has been shown to re...
The Deauville 5-Point Scale Improves the Prognostic Value of Interim FDG PET/CT in Extranodal Natural Killer/T-Cell Lymphoma
Authors: Chong Jiang, Minggang Su, Russell Oliver Kosik, Liqun Zou, Ming Jiang, Rong Tian
Journal: Clinical Nuclear Medicine (2015)

The prognostic value of FDG PET/CT in extranodal natural killer/T-cell lymphoma (ENKTL) is still controversial. Furthermore, the utility of the Deauville 5-point scale (DS) in ENKTL is uncertain. Therefore, we designed a prospective study to examine the prognostic value of 3 methods of PET/CT analysis (International Harmonization Project [IHP] criteria, DS, and SUV-based assessment).Sixty patients with newly diagnosed untreated ENKTL were enrolled. PET/CT evaluation was performed before initial treatment (pretreatment) and midtreatment (interim). Interim PET/CT response was determined based on IHP criteria, DS, and change in FDG uptake (ΔSUVmax). International Harmonization Project criteria, DS, and ΔSUVmax were then examined for the ability to predict progression-free survival (PFS) and overall survival (OS).Over a median follow-up of 23.5 months, interim PET/CT based on DS and ΔSUVmax were significant predictors of PFS and OS. After multivariate analysis, DS was an independent predictor of PFS (P < 0.001) and OS (P < 0.001). ΔSUVmax was an independent predictor of OS (P = 0.013) but not PFS (P = 0.054) and with a lower accuracy and positive predictive value than DS.Interim PET/CT analysis with DS predicts unfavorable treatment outcomes of ENKTL patients, whereas interim PET/CT analysis based on IHP criteria and SUV-based assessment have limited prognostic value.
Effects of helicopter service on survival after trauma
Authors: P. Greengross
Journal: BMJ (1995)

<h3>Abstract</h3> Defining the number, proportion, or lineage of distinct cell types in the developing human brain is an important goal of modern brain research. We defined single cell transcriptomic profiles for 40,000 cells at mid-gestation to identify cell types in the developing human neocortex. We define expression profiles corresponding to all known major cell types at this developmental period and identify multiple transcription factors and co-factors expressed in specific cell types, providing an unprecedented resource for understanding human neocortical development including the first single-cell characterization of human subplate neurons. We characterize major developmental trajectories during early neurogenesis, showing that cell type differentiation occurs on a continuum that involves transitions that tie cell cycle progression with early cell fate decisions. We use these data to deconvolute regulatory networks and map neuropsychiatric disease genes to specific cell types, implicating dysregulation of specific cell types, as the mechanistic underpinnings of several neurodevelopmental disorders. Together these results provide an extensive catalog of cell types in human neocortex and extend our understanding of early cortical development, human brain evolution and the cellular basis of neuropsychiatric disease. <h3>One Sentence Summary</h3> Comprehensive single cell transcriptomes in developing human cortex inform models of cell diversity, differentiation and disease risk.
Abstract 10194: Declining Age-Adjusted Prevalence, Incidence and Recurrence Rates Of Hospitalized Atherothrombotic Vascular Disease in the Australian Population
Authors: Tom Briffa, Lee Nedkoff, Matthew Knuiman, Paul E Norman, Joseph Hung, Graeme J Hankey, Peter L Thompson, Elizabeth Geelhoed, Siobhan Hickling, Frank Sanfilippo, Alexandra Bremner, Michael S Hobbs
Journal: Circulation (2011)

Background. Understanding the current epidemiology of hospitalized atherothrombotic disease affecting the coronary, cerebral, and peripheral arteries is vital for prevention and health service planning. Hospitalization for atherothrombotic disease is projected to rise due to better survival and population ageing. We determined sex and age-standardized trends in the prevalence, incidence and recurrence of atherothrombotic events requiring hospitalization in an Australian state from 2000 to 2007. Methods. Linked statewide records of hospitalizations for atherothrombotic disease were obtained from 1985 onwards. Sex and age-standardized (35-84 years) rates were derived using a 15-year lead-in to assess atherothrombotic disease. Results. In 2007, 45,916 (8.6%) men and 22,782 (4.3%) women had atherothrombotic disease requiring hospital treatment. From 2000 to 2007 there were 58,656 incident (63.4% men) and 48,920 recurrent cases (68.8% men), dominated by coronary artery disease causing 63.8% of the incident and...