tbuckley/cabot-search huggingface dataset:
Yeast-driven and Bioimpedance-sensitive Biohybrid Soft Robots
Authors: MennaAllah Soliman, Frederick Forbes, Dana D. Damian
Journal: Cyborg and Bionic Systems (2025)

Biohybrid robots integrate biological components with synthetic materials to harness the unique capabilities of living systems for robotic functions. This study focuses on leveraging yeast fermentation dynamics to enable actuation and sensing in soft robotic systems. By leveraging yeast’s natural ability to produce carbon dioxide and generate pressure during fermentation, we demonstrate the feasibility of creating biohybrid robots with lifelike behavior and adaptability. Our research integrates bioimpedance sensing into track yeast behavior and metabolic dynamics in real time. We developed an adjustable single-resistor oscillator circuit by using a digital potentiometer to measure impedance frequency and model the yeast growth rate. Experimental results reveal the sensitivity of the single-resistor oscillator circuit to variations in yeast concentration and demonstrate the correlation between yeast behavior and actuation power. Furthermore, we highlight the potential of yeast-driven robots for various applications by demonstrating a yeast-driven soft limb capable of rotating 140° tested at different temperatures, an inflatable membrane actuator functioning as a tactile sensor detecting forces up to 4.5 N, a palpation probe for differentiating tissue stiffness, and a gripper capable of manipulating objects. This work lays the foundation for advancing biohybrid robotics by integrating yeast fermentation dynamics with bioimpedance sensing, enhancing the functionality of robotic systems.
New potency labelling of topical corticosteroids in the UK
Authors: Celia Moss, Michael Ardern-Jones
Journal: British Journal of Dermatology (2025)

From June 2025 all topical steroids licensed in the UK will be labelled on the container and packaging as mild steroid, moderate steroid, strong steroid or very strong steroid. The designation will match the legal pharmaceutical category. British National Formulary has previously classified a few products differently and has now altered those designations to match the new labels.
Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss
Authors: Eliana O. Fischer, Anna Tsukerman, Majd Machour, Margarita Shuhmaher, Asaf Silverstein, Maya Yaakov, Orit Bar‐Am, Lior Debbi, Shulamit Levenberg
Journal: Advanced Healthcare Materials (2025)

Volumetric muscle loss (VML) refers to muscle tissue loss exceeding 20% within a functional area due to trauma or surgery, often leading to physical disabilities. VML treatment relies on the transplantation of autologous flaps harvested from a healthy-donor site while minimizing the probability of immune rejection. However, this approach often leads to donor-site morbidity and relies on a restricted supply of muscle tissue. Current solutions in tissue engineering focus on engineered grafts lacking hierarchical vasculature with a feeding vessel, thus limited by diffusion. This study expanded upon a new approach of multimodal bioprinting which enabled the fabrication of thick hierarchical vascular muscle flaps composed of bioprinted and vascularized skeletal muscle tissue, and a 3D-printed engineered macrovessel, which successfully repaired VML injury in-vivo. The flaps are implanted by anastomosing the macrovessel via microsurgery to the femoral artery in proximity to an induced VML injury in Sprague-Dawley rat hindlimbs. Immediate perfusion of the flaps is demonstrated, as is flap endurance to physiological blood pressure, flow, and shear stress. Flap implantation enhanced myocyte differentiation, and vascular ingrowth and facilitated tissue viability and integration. These results obtained by utilizing human-origin cells provide a foundation for fabricating patient-specific flaps for the treatment of extensive soft tissue defects.
Impact of Maternal BPA Exposure during Pregnancy on Obesity in Male Offspring: A Mechanistic Mouse Study of Adipose-Derived Exosomal miRNA
Authors: Zhenyao Huang, Rui Niu, Qiaoqiao Xu, Rui Zhang, Weiyue Hu, Yufeng Qin, Xinru Wang, Qiujin Xu, Yankai Xia, Yun Fan, Chuncheng Lu
Journal: Environmental Health Perspectives (2025)

The widespread use of bisphenol A (BPA) has led to universal exposure among the population, raising concerns about its health effects. Epidemiological studies have linked environmentally relevant levels of BPA exposure to obesity. We aimed to uncover the complex mechanisms by which oral exposure during pregnancy with BPA affects the offspring. We conducted a two-stage mouse study. In stage 1, we gavaged dams with BPA at 0.05, 0.5, and 5mg/kg per day during pregnancy, and we tracked the offspring's weight and diet to 12 wk of age. In stage 2, exosomes from BPA-exposed dams and offspring were injected into pregnant mice and 3-wk-old males, respectively, and the mice were observed up to 12 wk. We then sequenced exosomal microRNAs (miRNAs) in male offspring whose dams had been exposed to BPA during pregnancy and checked their expression in adipose, liver, and serum samples at weeks 3, 6, 9, and 12. Finally, we explored the functions of exosomes and exosomal miRNAs secreted by adipose-derived mesenchymal stem cells, and we investigated whether the exosomes and miRNAs they secreted could affect glucose uptake, triglyceride synthesis, and the expression of genes related to glucose and lipid metabolism in alpha mouse liver 12 cells. Gavage of 0.05mg/kg per day of BPA during pregnancy in dams led to obesity in male offspring mice, and injection of exosomes from male offspring with BPA exposure during pregnancy also induced similar outcomes in the next generation of male pups. Exosomal miRNA sequencing identified differentially expressed miRNAs associated with BPA-induced obesity in male offspring, revealing sustained high expression of miRNAs in adipose tissue and a gradual increase in the liver and serum over time. Further mechanistic studies showed that exosomes derived from BPA-treated adipose-derived stem cells reduced the expression of peroxisome proliferator-activated receptor-gamma and fibroblast growth factor 21, leading to impaired insulin signaling and lipid metabolism in hepatocytes. Overexpression of miR-124-3p in hepatocytes mimicked these effects; in contrast, knockdown of miR-124-3p or inhibition of exosome secretion reversed them. The present study corroborates the regulatory function of adipose-derived exosomal miRNAs in obesity in male offspring mice resulting from BPA exposure during pregnancy. Exosomal miRNA may be a key and novel molecular biomarker in the adverse effects of chemical exposure during pregnancy. https://doi.org/10.1289/EHP14888.
A Dual‐Pipeline Lactate Removal Strategy to Reverse Vascular Hyperpermeability for the Management of Lipopolysaccharide‐Induced Sepsis
Authors: Shuangfeng Ge, Xing‐Huo Wang, Juntao Fan, Haofei Liu, Youtao Xin, Xiaohui Li, Yunjian Yu, Ying‐Wei Yang, Hui Gao
Journal: Advanced Healthcare Materials (2025)

Sepsis is an underappreciated yet severe threat to human life, marked by organ dysfunction and high mortality resulting from disordered inflammatory responses to blood infection. Unfortunately, no specific drugs are available for effective sepsis treatment. As a pivotal biomarker for sepsis, lactate levels are closely related to vascular permeability and sepsis-associated mortality. Herein, a dual-pipeline lactate removal strategy is reported from circulating blood to ameliorate vascular permeability and lipopolysaccharide (LPS)-induced sepsis. This is achieved by formulating lactate oxidase (LOX)-encapsulated hollow manganese dioxide (HMnO2) nanohybrids (LOX@HMnO2-P[5]A) bearing pillar[5]arene (P[5]A) macrocycle with excellent host-guest properties. The highly biocompatible nanohybrids enable direct lactate consumption through LOX catalytic degradation and block lactate production by P[5]A-mediated LPS trapping, allowing for dual-pipeline lactate removal to maximize the reversal of lactate-mediated vascular hyperpermeability. Besides, HMnO2 cores decompose hydrogen peroxide produced from lactate oxidation into oxygen, further contributing to lactate consumption and mitigating the hypoxic inflammatory environment. In vivo investigations demonstrate that intravenous administration of LOX@HMnO2-P[5]A nanohybrids with extended blood circulation can effectively ameliorate endothelial barrier dysfunction, inflammatory responses, and multiple organ injury, ultimately improving survival outcomes in LPS-induced sepsis. Taken together, this dual-pipeline lactate removal strategy offers a promising approach for efficient sepsis treatment.
Facile Fabrication of Injectable Multifunctional Hydrogels Based on Gallium‐Polyphenol Networks with Superior Antibacterial Activity for Promoting Infected Wound Healing
Authors: Minglang Zou, Cuiping Chen, Mingda Wang, Chen Lei, Yongming Wang, Fang Luo, Da Huang, Meishui Wang, Houbing Zheng, Biao Wang, Zhenyu Lin, Zuquan Weng
Journal: Advanced Healthcare Materials (2025)

Multifunctional hydrogels hold significant promise for promoting the healing of infected wounds but often fall short in inhibiting antibiotic-resistant pathogens, and their clinical translation is limited by complex preparation processes and high costs. In this study, a multifunctional hydrogel is developed by combining metal-phenolic networks (MPNs) formed by tannic acid (TA) and gallium ions (Ga3⁺) with chitosan (CS) through a simple one-step method. The resulting CS-TA-Ga3⁺ (CTG) hydrogel is cost-effective and exhibits desirable properties, including injectability, self-healing, pH responsiveness, hemostasis, antioxidant, anti-inflammatory, and antibacterial activities. Importantly, the CTG hydrogels are effective against antibiotic-resistant pathogens due to the unique antibacterial mechanism of Ga3⁺. In vivo studies demonstrate that the CTG hydrogel promotes follicle formation and collagen deposition, accelerating the healing of infected wounds by inhibiting blood loss, suppressing bacterial growth, and modulating the inflammatory microenvironment. These findings highlight the CTG hydrogel's potential as an advanced and translational dressing for enhancing the healing of infected wounds.
Diagnosis and treatment of AML in the context of WHO and ICC 2022 classifications: Divergent nomenclature converges on common therapies
Authors: Uwe Platzbecker, Richard A. Larson, Sandeep Gurbuxani
Journal: HemaSphere (2025)

As a consequence of rapidly developing genetic technologies and advances in the understanding of the pathogenesis of acute myeloid leukemia (AML), the classification of AML has moved gradually from a morphologic and cytochemical-based system to one that is genetically defined. Recent molecular and genetic developments have been integrated into the diagnostic criteria for AML in the fifth edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours and the 2022 International Consensus Classification (ICC) of Myeloid Neoplasms and Acute Leukemias, expanding the list of genetically defined entities. In this review article, we use a case-based format describing the diagnostic workup, risk stratification, and possible treatment options to highlight the impact of the 2022 WHO and ICC classifications on clinical practice. We show that despite much commentary and anguish, there is a significant overlap between the two classifications. We further highlight the fact that even for entities with divergent nomenclature, such as TP53-mutated AML, the actual genetic lesion leads to convergent therapy.
Bioprinted Micro‐Clots for Kinetic Analysis of Endothelial Cell‐Mediated Fibrinolysis
Authors: Jonathan J. Chang, Kelsey Brew, Jamie A.G. Hamilton, Varun Kumar, José A. Diaz, Shuichi Takayama
Journal: Advanced Healthcare Materials (2025)

Vascular hypo-fibrinolysis is a historically underappreciated and understudied aspect of venous thromboembolism (VTE). This paper describes the development of a micro-clot dissolution assay for quantifying the fibrinolytic capacity of endothelial cells - a key driver of VTE development. This assay is enabled using aqueous two-phase systems (ATPS) to bioprint microscale fibrin clots over human umbilical vein endothelial cells (HUVECs). Importantly, these micro-clots are orders of magnitude smaller than conventional fibrin constructs and allow HUVEC-produced plasminogen activators to mediate visually quantifiable fibrinolysis. Using live-cell time-lapse imaging, micro-clot dissolution by HUVECs is tracked, and fibrinolysis kinetics are quantified. The sensitivity of cell-driven fibrinolysis to various stimuli is rapidly tested. The physiological relevance of this convenient high-throughput assay is illustrated through treatments with lipopolysaccharide (LPS) and rosuvastatin that elicit anti- and pro-fibrinolytic responses, respectively. Furthermore, treatment with baricitinib, an anti-inflammatory therapeutic found to increase cardiovascular risks after market approval, provokes an anti-fibrinolytic response - which highlights the potential role of endothelial cells in increasing VTE risk for patients receiving this drug. This endothelial cell fibrinolysis assay provides a high-throughput and versatile drug testing platform - potentially allowing for early preclinical identification of therapeutics that may beneficially enhance or adversely impair endothelial fibrinolysis.
Bioengineering Strategies for Treating Neointimal Hyperplasia in Peripheral Vasculature: Innovations and Challenges
Authors: Nikita Wilson John, Caitlyn Dang, Nidhi Reddy, Calvin Chao, Karen J. Ho, Bin Jiang
Journal: Advanced Healthcare Materials (2025)

Neointimal hyperplasia, a pathological response to arterial interventions or injury, often leads to restenosis and recurrent narrowing or occlusion, particularly in the peripheral vasculature. Its prevalence and negative impact on the long-term success of vascular interventions have driven extensive research aimed at better understanding the condition and developing effective therapies. This review provides a comprehensive overview of emerging bioengineering strategies for treating neointimal hyperplasia in peripheral vessels. These approaches include novel therapeutics and cell-based technologies designed to promote re-endothelialization, modulate vascular smooth muscle cell (VSMC) phenotype, reduce inflammation, scavenge reactive oxygen species (ROS), and enhance biomechanical compatibility between grafts and native vessels. Furthermore, advanced therapeutic delivery modalities are highlighted for their potential to achieve targeted, localized treatment at injury sites. This review also explores underrepresented therapeutic targets beyond traditional approaches, offering new opportunities for intervention. The multifaceted examination underscores the challenge of neointimal hyperplasia and presents a promising roadmap toward more effective treatments, ultimately aiming to improve patient outcomes after vascular interventions.
Correction: YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment
Authors: Zhenyun Yang, Xin Wang, Yizhen Fu, Weijie Wu, Zili Hu, Qingyang Lin, Wei Peng, Yangxun Pan, Juncheng Wang, Jinbin Chen, Dandan Hu, Zhongguo Zhou, Li Xu, Yaojun Zhang, Jiajie Hou, Minshan Chen
Journal: Molecular Cancer (2025)
Oral and Gut Microbial Hubs Associated With Reaction Threshold Interact With Circulating Immune Factors in Peanut Allergy
Authors: Lingdi Zhang, Yoojin Chun, Galina Grishina, Tracy Lo, Kyle Reed, Julie Wang, Scott Sicherer, M. Cecilia Berin, Supinda Bunyavanich
Journal: Allergy (2025)

Among peanut-allergic individuals, there is high variability in the amount of peanut that triggers reactions (i.e., reaction threshold) that is not predictable or well-understood. We conducted this study to characterize relationships between the oral and gut microbiomes and systemic processes associated with reaction threshold in peanut allergy (PA). In a cohort of 120 children with suspected PA who underwent double-blind, placebo-controlled food challenges, we generated and analyzed parallel profiles of the oral microbiome, gut microbiome, peripheral blood transcriptome, peripheral blood cytometry, and serum antibody levels to identify threshold-associated markers and their inter-relationships. The 120 participants included 23 children with no PA, 74 with high-threshold PA (reacting to ≥ 443 mg cumulative peanut protein), and 23 with low-threshold PA (reacting to < 443 mg cumulative peanut protein). Ten hub microbes were each identified in saliva and stool microbiome networks that were constructed, including the hub microbes Rothia aeria in saliva and Bacteroides sp. in stool that were associated with reaction threshold. These hub microbes were also associated with peripheral blood transcript levels for threshold-associated key drivers of FcγR-mediated phagocytosis and TLR signaling. Correlation network construction with additional data on threshold-associated peripheral blood neutrophil abundance and peanut-specific serum IgE and Ara h 2 antibody levels revealed central roles for saliva Rothia aeria and stool Bacteroides sp. in local-systemic networks for IgE- and IgG-mediated peanut allergy. This integrated study of oral and stool microbiomes, blood transcriptome, cellular profiles, and peanut-specific serum antibodies revealed new relationships between local microbiota and systemic measures associated with reaction threshold in peanut allergy.
Almost, but not quite there: Research into the emergence of higher-order motivated behavior should fully embrace the dynamic systems approach
Authors: Christophe Gernigon, Rémi Altamore, Robin R Vallacher, Paul L C van Geert, Ruud J R Den Hartigh
Journal: Behavioral and Brain Sciences (2025)

Abstract Murayama and Jach rightfully aim to conceptualize motivation as an emergent property of a dynamic system of interacting elements. However, they do not embrace the ontological and paradigmatic constraints of the dynamic systems approach. They therefore miss the very process of emergence and how it can be formally modeled and tested by specific types of computer simulation.
The unboxing has already begun: One motivation construct at a time
Authors: Ruud Custers, Baruch Eitam, E Tory Higgins
Journal: Behavioral and Brain Sciences (2025)

Abstract Murayama and Jach argue that it is not clearly specified how motivation constructs produce behavior and that this black box should be unpacked. We argue that the authors overlook important classic theory and highlight recent research programs that already started unboxing. We feel that without relying on the mechanisms that such programs uncover, the proposed computational approach will be fruitless.
Human motivation is organized hierarchically, from proximal (means) to ultimate (ends)
Authors: Edgar Dubourg, Valérian Chambon, Nicolas Baumard
Journal: Behavioral and Brain Sciences (2025)

Abstract Murayama and Jach raise a key problem in behavioral sciences, to which we suggest evolutionary science can provide a solution. We emphasize the role of adaptive mechanisms in shaping behavior and argue for the integration of hierarchical theories of goal-directed cognition and behavioral flexibility, in order to unravel the motivations behind actions that, in themselves, seem disconnected from adaptive goals.
Needed: Clear definition and hierarchical integration of motivation constructs
Authors: Andrew J Elliot, Nicolas Sommet
Journal: Behavioral and Brain Sciences (2025)

Abstract Murayama and Jach offer a thoughtful and timely critique of motivation constructs. We largely concur with their basic premises, but offer additional input and clarification regarding the importance of carefully considering the energization and direction components of motivation, and fully attending to the hierarchical aspect of motivation rather than prioritizing particular levels of analysis.
Exploring novelty to unpack the black-box of motivation
Authors: Nico Bunzeck, Sebastian Haesler
Journal: Behavioral and Brain Sciences (2025)

Abstract Murayama and Jach point out that we do not sufficiently understand the constructs and mental computations underlying higher-order motivated behaviors. Although this may be generally true, we would like to add and contribute to the discussion by outlining how interdisciplinary research on novelty-evoked exploration has advanced the study of learning and curiosity.
Motivation needs cognition but is not just about cognition
Authors: Nathalie André, Roy F Baumeister
Journal: Behavioral and Brain Sciences (2025)

Abstract Murayama and Jach offer valuable suggestions for how to integrate computational processes into motivation theory, but these processes cannot do away with motivation altogether. Rewards are only rewarding because people want and like them – that is, because of motivation. Sexual desire is not primarily a quest for rewarding information. Elucidating the interface between motivation and cognition seems a promising way forward.
Poliovirus detections in Europe – urgent action needed to keep Europe polio-free
Authors: Pamela Rendi-Wagner, Hans Kluge
Journal: Eurosurveillance (2025)

Preview this article: Poliovirus detections in Europe – urgent action needed to keep Europe polio-free, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/30/4/eurosurv-30-4-1-1.gif
Multiple variants of tick-borne encephalitis virus in voles, mice and ticks, the Netherlands, 2021 to 2023
Authors: Emily L Pascoe, Julian W Bakker, Sara R Wijburg, Ankje de Vries, Hein Sprong, Matteo Marcantonio, Daniel Lang, Gerhard Dobler, Clara F Köhler, Helen J Esser, Constantianus JM Koenraadt
Journal: Eurosurveillance (2025)

Background Tick-borne encephalitis (TBE) can be a severe neurological disease. Identifying ecological factors that may facilitate tick-borne encephalitis virus (TBEV) circulation in the Netherlands could improve awareness and detection. Aim We aimed to identify ecological factors affecting TBEV circulation in the Netherlands and to determine if there is sustained circulation and spread of the virus. Methods Between June and September 2021, rodents and ticks from three previously TBEV-positive locations were tested for TBEV by PCR. We sequenced TBEV and compared the sequences with previous and subsequent sequences from the Netherlands and other countries to investigate the spread of TBEV-variants. Results We captured 383 rodents, 928 feeding ticks and 1,571 questing Ixodes ticks and detected TBEV from six (three Apodemus sylvaticus and three Clethrionomys glareolus ) (2.9%) of 206 tested rodents and two (0.9%) of 215 questing tick pools. Detection of TBEV was associated with questing tick density (Mann–Whitney U test = 81.5; 95% confidence interval (CI): − 3.7–6.3 × 10 −5 ; p = 0.05). Tick larvae (odds ratio (OR) = 9.0; 95% CI: 2.8–38.2; p &lt; 0.01) and nymphs (OR = 3.8; 95% CI: 1.3–13.6; p &lt; 0.01) were more frequent on A. sylvaticus than on C. glareolus. Sequence comparisons suggest multiple introductions and local circulation of TBEV but no spread among locations. Conclusion Tick-borne encephalitis virus occurs in diverse woodlands in the Netherlands, posing a risk to those frequenting these areas. Surveillance for the early detection and monitoring of TBEV spread, along with public awareness campaigns on preventive measures, should continue. Recognition of TBE symptoms and supportive diagnostics should be made available nationwide.
Motivational whack-a-mole: Foundational boxes cannot be unpacked
Authors: Ezgi Ozgan, Jedediah W P Allen
Journal: Behavioral and Brain Sciences (2025)

Abstract The proposed “black-box” problem and its solution are drawn from the same substance-oriented framework. This framework's assumptions have consequences that re-create the black-box problem at a foundational level. Specifically, Murayama and Jach's solution fails to explain novel behavior that emerges through an organism's development. A process-oriented theoretical shift provides an ontological explanation for emergent behavior and eliminates the black-box problem altogether.