tbuckley/cabot-search huggingface dataset:
Relative risks should not have been adjusted for body mass index
Authors: A. Astrup
Journal: BMJ (1996)

compared with targets in the Health of the Nation3 a smaller proportion of the fifth of the population in the study that had the highest saturated fat intake smoked cigarettes (14.4% v 20%, the British target for 2000) and this fifth of the population was the only one to derive more than 35% of total food energy from fat (the Brit- ish target for 2005).Mean alcohol consumption was low in all the groups, at below 14 units a week, whereas the Health of the Nation's target for 2005 is to reduce the proportion of adult men drinking 21 units a week to 18% (taking 1 unit as 8.5 g alcohol4).Furthermore, only one group failed to achieve the British target of eating five servings of vegetables and fruit a day.Regardless of the representativeness of the American health professionals, the reported mean serum cholesterol concentration of the groups was remarkably consistent at 5.2-5.3mmol/l.
Efficacy of Dual Inhibition of p38 Mitogen Activated Protein Kinase (MAPK) and Tie-2 Kinase in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)
Authors: Lohith Shakaladevanapura Bachegowda, Ioannis Mantzaris, Kerry A. Morrone, Nandini Keshkar, Weijuan Li, George Nwankwo, Samira Shahnaz, Tushar D. Bhagat, Orsolya Giricz, Sanchari Bhattacharrya, Yiting Yu, Carolina D. Schinke, Aby Pynadath, Andrea Pellagatti, Jacqueline Boultwood, Michael J Humphries, Shannon L Winski, Matthias Bartenstein, Chandan Guha, Leonidas Platanias, Ulrich Steidl, Amit Verma
Journal: Blood (2014)
Abstract 19230: Is Sodium Channel-Blocker Test Justified in All Subjects With a Non-Diagnostic Brugada-Like ECG?
Authors: Alessandro Zorzi, Federico Migliore, Alessio Marinelli, Elena Marras, Anna Baritussio, Loira Leoni, Gianfranco Buja, Sabino Iliceto, Pietro Delise, Domenico Corrado
Journal: Circulation (2010)

Background: Non diagnostic Brugada-like ECG abnormalities, which overlap with normal early repolarization, include J point elevation ≥2 mm with a saddle-back ST-segment elevation, either ≥1mm (type...
Abstract 2086: Community-Dwelling African-American Beliefs Associated with Adherence to Antihypertensive Medications: A Matter of Life and Death
Authors: Lisa M Lewis
Journal: Circulation (2008)

Medication adherence is low among hypertensive patients regardless of ethnic background. However, African-American prevalence is higher when compared to Caucasian-Americans. Recognizing African-American perspectives about their adherence to antihypertensive medications is necessary for the development of successful interventions aimed at improving adherence to prescribed regimens. Thus, the purpose of this qualitative study was to explore community-dwelling hypertensive African-American beliefs regarding adherence to antihypertensive medications. A community and academic partnership was formed to conduct three focus groups with 40 participants at two community centers in a Northeastern urban city. Each focus group was recorded and transcribed verbatim. We analyzed the focus group data using thematic analysis. Participants had a mean age of 57 years, were mostly female (n=27), high school graduates (n=14), unemployed (n=27), and earned an annual income of $20, 000 or less (n=18). In addition, they had a mean hypertension diagnosis of 8 years with most participants reporting adherence to their antihypertensive medication regimens (n=26). Study participants described salient beliefs regarding their adherence to antihypertensive medications. Data analysis revealed an overarching theme of “it’s a matter of life and death” in which study participants were able to articulate the health benefits associated with adhering to their medications but also described the difficulties associated with adherence in relation to their social contexts. Participants identified three major difficulties associated with the remaining adherent to their antihypertensive medications. The difficulties included: (a) negotiating their limited resources, (b) negotiating their neighborhood violence, and (c) negotiating their feelings of mistrust of doctors. Although these results cannot be generalized, they do provide significant insight into the contextual factors associated with the lives of some community-dwelling hypertensive African-Americans. These findings are important because they can be used to tailor interventions to increase medication adherence in hypertensive African-Americans.
Abstract 15515: Exosomes from Adult Human CD34+ Stem Cells Transfer Crucial Pro-Angiogenic MiRNA Inducing Functional Changes in Target Cells
Authors: Susmita Sahoo, Tina Thorne, Kathryn M Schultz, Meredith Millay, Ting Liu, Ekaterina Klyachko, Douglas W Losordo
Journal: Circulation (2011)

In early clinical trials, human CD34+ stem cells (CD34) have been shown to improve exercise tolerance in patients with myocardial ischemia and reduce amputation rates in limb ischemia. Pre-clinical...
Comparative analysis of performance of DAS 28 and new indexes SDAI and CDAI in early arthritis: Are they equally useful for assessment of disease activity and therapeutic decision making?
Authors: L. K. N. Guedes, S. Kowalski, A. C. Medeiros, C. Goncalves, F. S. F. Neves, J. C. B. Moraes, K. Ebina, P. Martin, J. A. L. Kochen, I. M. M. Laurindo
Journal: Annals of the Rheumatic Diseases (2006)
Abstract 11535: Elimination of Recurrent Atrial Fibrillation by Focal Impulse and Rotor Modulation (FIRM) Alone
Authors: Sanjiv M Narayan, Ruchir Sehra, Carey Briggs, David E Krummen
Journal: Circulation (2011)

Introduction: Atrial fibrillation (AF) may recur in a third or more of patients after pulmonary vein isolation (PVI). We hypothesized that electrical rotors or repetitive focal impulses, localized sources recently demonstrated in human AF, may be sites where targeted ablation (Focal Impulse and Rotor Modulation, FIRM) alone may eliminate recurrent AF. Methods: In 35 AF patients (63±9 years; LA size 48±7 mm; 24 persistent), we recorded AF at 128 electrodes using basket catheters in both atria. Applying a novel physiological mapping system to identify sources, we performed FIRM ablation directly at AF rotors/focal impulses (endpoint: AF termination or 10 minutes' ablation; repeated for ≤ 3 sources). In Group I, ablation stopped at this point (i.e. no PVI). In Group II, circumferential PVI (CPVI) was then performed after FIRM. Results: All patients exhibited AF sources, for an average of 2.2±0.9 rotors (n=49) and/or focal beats (n=23). FIRM terminated AF (n=21; within 6.6±5.4 minutes) or greatly slowed AF (n...
Abstract 13376: Lipid-Lowering Therapy Decreases Common Carotid Artery Intima-Media Thickness (IMT) Progression in Individuals Free of Prevalent Cardiovascular Disease: The Framingham Heart Study
Authors: Joseph F Polak, Allison Meisner, Michael J Pencina, Philip A Wolf, Ralph B D'Agostino
Journal: Circulation (2011)

Background: Common carotid artery (CCA) intima-media thickness (IMT) is a surrogate measure of atherosclerosis. Pharmacologic intervention decreases IMT progression in intervention trials but these...
Pegylated Arginine Deiminase (ADI-PEG20) in Relapsed/Refractory and/or Elder Acute Myeloid Leukemia: The Preliminary Result of Phase II Trial
Authors: Hui-Jen Tsai, Ming-Chung Wang, Sheng-Fung Lin, Ya-Ping Chen, Hui-Hwa Hsiao, Ching-Yuan Kuo, Li-Tzong Chen, Tsai-Yun Chen
Journal: Blood (2014)
Abstract 14591: Where to Position ECG Leads to Detect the Brugada Phenotype? Correlation of ECG and Cardiovascular Magnetic Resonance Imaging
Authors: Christian Veltmann, Torsten Konrad, Christiana Doesch, Juergen Kuschyk, Boris Rudic, Turgay Goeksu, Martin Borggrefe, Christian Wolpert, Rainer Schimpf, Theano Papavassiliu
Journal: Circulation (2011)

Background: Brugada syndrome is characterized by ST-segment abnormalities in V1-V3. ECG recording using leads V1 and V2 in the 3rd and 2nd intercostal space (ICS) increases the sensitivity for the ...
Abstract 1924: Carriers of Loss-of-Function Mutations in ABCA1 Display Pancreatic Beta Cell Dysfunction
Authors: Menno Vergeer, Liam R Brunham, Joris Koetsveld, Janine K Kruit, C B Verchere, John J Kastelein, Michael R Hayden, Erik S Stroes
Journal: Circulation (2008)

Background The ATP Binding Cassette transporter A1 (ABCA1) transports free cholesterol to nascent high-density lipoproteins (HDL) and maintains plasma HDL levels. In mice, ABCA1 is essential in regulating intracellular cholesterol homeostasis and insulin secretion in the β cell. The role of ABCA1 in human glucose metabolism is unclear. Objective and methods To assess the effects of ABCA1 dysfunction on glucose homeostasis in humans , we matched heterozygous carriers of disruptive mutations in ABCA1 and non-carriers for age, gender and BMI and performed oral glucose tolerance tests (OGTT; 9 vs. 8 respectively) and hyperglycemic clamping experiments (6 vs. 6). Results Carriers had lower HDL-C levels than non-carriers (0.58 ± 0.3 vs. 1.46 ± 0.4 mmol/L, p=0.001) but LDL-C did not differ (3.4 ± 1.0 vs. 2.8 ± 0.8 mmol/L, p=0.21). Fasting plasma glucose was not different (5.2 ± 1.5 vs. 5.0 ± 0.4 mmol/L). Glucose curves after OGTT were significantly higher in carriers than in non-carriers (genotype * time interaction, p=0.005; plasma glucose at t=60 min 9.0 ± 3.0 mmol/L vs. 6.0 ± 1.4 mmol/L respectively, p=0.02). During hyperglycemic clamps, carriers showed a lower first phase insulin and C-peptide response than non-carriers (genotype * time interaction, p&lt;0.05 and p&lt;0.01 respectively; insulin at t=5 min 164±118 vs. 352 ±141 pmol/L, p&lt;0.05; C-peptide at t=5 min 1033 ± 628 vs. 1942 ± 723 pmol/L, p&lt;0.05) but no difference in insulin sensitivity index (0.0216 ± 0.012 mg kg −1 . min −1 . pM −1 for carriers and 0.0197 ± 0.005 mg kg −1 . min −1 . pM −1 for non-carriers; p=0.73). Disposition index - a measure of β cell function, adjusted for insulin sensitivity - was lower in carriers than in non-carriers (1037 ± 610 vs. 2718 ± 1524; p&lt;0.05). Non-carriers responded to an arginine stimulus with an increase in C-peptide levels (from 3558 ± 1240 pM to 6817 ± 1665 pM; p&lt;0.005), whereas in carriers this increase did not reach statistical significance (from 3727 ± 1843 pM to 5480 ± 1757 pM; p=0.12). Conclusion Carriers of loss-of-function mutations in ABCA1 show impaired insulin secretion without insulin resistance, resulting in glucose intolerance. Our data confirm previous studies in mice and provide evidence for a role of ABCA1 in β cell dysfunction and the pathophysiology of diabetes mellitus in man.
Hemoglobin A_1c Reproducibility
Authors: GEORGE G. RHOADS
Journal: Annals of Internal Medicine (1980)

Letters1 April 1980Hemoglobin A1c ReproducibilityGEORGE G. RHOADS, MD., M.P.H.GEORGE G. RHOADS, MD., M.P.H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-4-574 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their article on reproducibility of hemoglobin A1cDunn and associates (1) provide much useful information about this promising laboratory procedure but none on its reproducibility. Because thelackof reproducibility of the standard estimates of glucose tolerance has been a major handicap to the interpretation of these tests, such data for the new procedure would be of considerable interest. Their repeat measurements in 121 persons (Group 3) should provide useful information on this point that could be simply expressed as the correlation coefficients between the first and second measurements of hemoglobin A1cand of fasting glucose....References1. DUNN P, COLE R, SOELDNER J, and GLEASON R. Reproducibility of hemoglobin A1c and sensitivity to various degrees of glucose intolerance. Ann Intern Med. 1979;91:390-6. LinkGoogle Scholar1. DUNN P, COLE R, SOELDNER J, and GLEASON R. Reproducibility of hemoglobin A1c and sensitivity to various degrees of glucose intolerance. Ann Intern Med. 1979;91:390-6. LinkGoogle Scholar2. GANDA O, DAY J, SOELDNER J, CONNON J, and GLEASON R. Reproducibility and comparative analysis of repeated intravenous and oral glucose tolerance tests. Diabetes. 1978;27:715-25. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE G. RHOADS, MD., M.P.H. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1980Volume 92, Issue 4Page: 574-574KeywordsGlucoseGlucose toleranceHemoglobinReproducibilityResearch laboratories ePublished: 1 December 2008 Issue Published: 1 April 1980 PDF downloadLoading ...
Abstract 13518: Increased Protein and Increased Ca2+ Sensitivity are Both Responsible for the Increased Apamin-Sensitive K+ Current In Failing Human Ventricles
Authors: Po-Cheng Chang, Zhenhui Chen, John C Lopshire, Isik Turker, Christopher L Corr, Susan P Straka, Jason B Garlie, Su-Kiat Chua, Mitsunori Maruyama, Thomas C Wozniak, John W Brown, Mark W Turrentine, Jacqueline A O'Donnel, Irmina Gradus-Pizlo, Adnan Malik, Shien-Fong Lin, Peng-Sheng Chen, Tomohiko Ai
Journal: Circulation (2011)

Introduction: Our recent studies showed that apamin-sensitive K+ current (IKAS), a major component of small conductance Ca2+-activated K+ (SK) current, is upregulated in human failing ventricles. T...
Abstract 17338: Effect of Symptom Awareness Training on Heart Failure Self-Care and Symptom Burden
Authors: Corrine Jurgens, Barbara Riegel
Journal: Circulation (2011)

Symptom severity is associated with timely care-seeking among heart failure (HF) patients. Delay in responding to symptoms frequently results in escalating symptom severity by the time patients seek care. The study purpose was to test the effect of an interactive symptom training protocol on self-care, symptom burden and health provider contact. Method: Using a randomized controlled trial design, 46 HF patients were randomized to a symptom training protocol or usual HF education. All received a weight scale and self-care booklet. Intervention patients received interactive training on symptom recognition and use of a daily symptom graph. HF self-care was measured using the Self-Care of HF Index (SCHFI) at baseline, 3 and 6 months, higher scores indicate better self-care. HF symptom severity was measured with the HF Somatic Perception Scale (HFSPS). Scores range 0-90 with higher scores indicating higher symptom burden. Emergent calls to providers were documented by telephone interview at 1, 3 and 6 months. Self-care and symptom severity were analyzed with repeated measures ANOVA. Results: The sample mean age was 71.4 years, SD 10.9, 39% female, 87% White and functionally compromised (78% NYHA III-IV). Both groups had clinically relevant improvement in SCHFI maintenance and management scores at 3 months and some further improvement in maintenance scores at 6 months, but no significant differences between groups. Despite similar SCHFI scores at 6 months, the mean HFSPS score was 50% lower in the intervention group (10.6 vs 20.4, p=.03). The intervention group initiated more contacts with health providers than the usual care group (10 vs 8). Implications: Patients receiving symptom training demonstrated improvement in symptom recognition ability although self-care scores were no different than those of the control group. Better symptom recognition may be responsible for increased contact with health providers by those in the intervention group.
Factors Affecting Clinical Outcomes after CLAG/CLAG-M Chemotherapy in Relapsed/Refractory Acute Myeloid Leukemia
Authors: Hyunkyung Park, Jeonghwan Youk, Youngil Koh, Inho Kim, Seonyang Park, Jeong-Ok Lee, Soo-Mee Bang, Hyo Jung Kim, Hwi-Joong Yoon, Junglim Lee, Sung-Soo Yoon
Journal: Blood (2014)
Effect of id1 and id2 proteins (inhibitors of dna binding) expression in human colorectal cell lines
Authors: B. Calvo, A. Muñoz, M. Jangi, U. Aresti, A. Garcia, A. Alonso, I. Marrodan, A. Moreno, G. Lopez-Vivanco, S. Carrera
Journal: Journal of Clinical Oncology (2009)

e22179 Background: Id1 and Id2 proteins are negative regulators of basic helix-loop-helix transcription factors, a family of components in the transcriptional network regulating cell growth and differentiation. Id1 and Id2 are overexpressed in human colorectal carcinoma and might play a critical role in the malignant cell phenotype. Methods: Two cell-lines were use for the analysis. NCM460: immortal non-tumoral cells from colon mucosa, and Caco-2: epithelial cells from colorectal carcinoma. Cell-lines were transfected with different constructs based on pLXSN vector (Clontech) to overexpress or inhibit the expression of the Id1 and Id2 genes, and then cultured for the analysis. Quantification of Id1 and Id2 expression were assessed by RT-PCR and Western-blot, respectively. A gene expression profile using oligonucleotide microarrays (Agilent Technologies) was performed in each cell line. Results: NCM460 cells and Caco-2 cells overexpressing Id1 (NCM460-Id1 and Caco-2-Id1) showed a statistically significant higher proliferation, invasion and migration, compared with both normal and Id1 inhibited cells. Id2 overexpression was related with a higher invasion capability only in NCM460 cells, without significant effect on proliferation and migration. NCM460-Id1 cells showed overexpression of PTMA, TYMS and LMNB1 genes, whereas HOXB8, LRP1, MMP17, NDRG1, MAP3K10, SCGb3A1 and BBC3 were upregulated. PTP4A1 and DKK1 were overexpressed in Caco-2-Id1 cells, and NDRG1, LRP1, FMOD and ENO1 were repressed. Conclusions: Id-1 expression is associated with proliferation, migration and invasion in both normal and tumoral colonic cell lines, and it is related with regulation of several genes implicated in colorectal cancer phenotype. Id proteins might be a potential target for the development of new antineoplastic agents. No significant financial relationships to disclose.
P0456 : Re-evaluation of HBV clinical phases by system biology identifies unappreciated roles for the innate immune response and B cells
Authors: T. Vanwolleghem, J. Hou, G.W. van Oord, A.C. Andeweg, A.D. Osterhaus, S.D. Diepstraten-Pas, H.L. Janssen, A. Boonstra
Journal: Journal of Hepatology (2015)
Assessing methodological quality of published papers
Authors: M. Gossop, J. Marsden, P. Daish
Journal: BMJ (1998)

patient.Surely this is an argument not for compliance but for concordance.Thirdly, they remind us that threats to the public health (posed, in their example, by non-compliant patients with open pulmonary tuberculosis) demand nothing less than strict compliance with drug treatment, in the public interest.There are similar examples from forensic mental health.Nothing in the concept of concordance asserts the necessary primacy of individual autonomy over the needs of society.In setting out our agenda of research, training, and public awareness, our working party was only too aware that we were not providing definitive answers to the problems caused by non-compliance in medicine taking.Rather, we wished to suggest a more productive way of asking the questions
Abstract 15557: Altered Cardiovascular Phenotype in Young Adults Born Premature: A 25-Year Prospective Follow-Up Study
Authors: Adam J Lewandowski, Merzaka Lazdam, Esther F Davis, Rajarshi Banerjee, Jonathan Diesch, Jane Francis, Stefan Neubauer, Atul Singhal, Alan Lucas, Paul Leeson
Journal: Circulation (2011)

Background - Premature birth is a risk factor for increased blood pressure (BP) in young adulthood, though the underlying mechanisms are incompletely understood. We thus studied in detail the impac...
Abstract 672: Association of High-Density Lipoprotein Subclass and Atherosclerotic Remodeling as Measured by Magnetic Resonance Imaging of Internal Carotid Arteries in an Elderly Population with Known Atherosclerosis
Authors: Sachin Agarwal, Amy E Spooner, Margene A Kennedy, David A Bluemke, Ilan Gottlieb, Joao A Lima
Journal: Circulation (2006)

Background: Large, buoyant high density lipoprotein, also known as HDL subclass 2 (HDL2),and small, dense HDL, also known as HDL subclass 3 (HDL3) are thought to exert variable protective effects a...
Silence of advanced nations on the refugee crisis is shameful
Authors: J. Ting
Journal: BMJ (2015)

Indonesia and Malaysia have just announced the provision of assistance to 7000 desperately stranded migrants. The offer to provide temporary shelter before resettlement and repatriation needs to include resettlement to advanced economies, such as Australia, the US, and the UK. The silence of these nations, which have yet to offer substantial assistance, is shameful and should be …
T Large Granular Lymphocytes Leukemia (T-LGLL) and Natural Killer Chronic Lymphoproliferative Disorder (NK-CLPD): Two Diseases With a Common Etiopathogenetic Mechanism?
Authors: Cristina Gattazzo, Antonella Teramo, Chiara Nardin, Francesca Passeri, Gregorio Barilà, Valentina Trimarco, Alberto Pavan, Samuela Carraro, Elena De March, Monica Facco, Livio Trentin, Gianpietro Semenzato, Renato Zambello
Journal: Blood (2013)
The effect of depression on survival in patients with newly diagnosed advanced non-small cell lung cancer (NSCLC)
Authors: J. S. Temel, V. A. Jackson, A. Billings, H. G. Prigerson, P. Fidias, T. J. Lynch, W. Pirl
Journal: Journal of Clinical Oncology (2006)

8511 Background: The impact of emotional distress on cancer-related mortality is unclear. Divergent results in studies are due, in part, from heterogeneous populations in terms of type of cancer, stage of disease, and time of emotional assessment. This study examined the effect of depression and anxiety on a well-defined cohort of patients with newly diagnosed advanced NSCLC. Methods: 46 patients with advanced NSCLC were recruited within eight weeks of diagnosis to participate in a feasibility study of early palliative care. Participants completed the Hospital Anxiety and Depression Scale (HADS) at baseline and were followed for six months. The primary study endpoint was survival at six months. The effects of depression and anxiety were evaluated first by Kaplan-Meier survival analysis and then by Cox regression to control for other variables. Results: Three patients (6%) had stage IIIB with effusions and the remaining 43 (93%) had stage IV disease. The median age of patients was 65.5 years and 28 of the 46 (61%) were women. 34 patients had a PS 1 (74%), 11 (24%) had PS 0 and one (2%) had PS 2. 96% of the patients completed the baseline HADS. 23% met HADS criteria for probable cases of depression (8 or greater) at baseline and 34% met HADS criteria for probable cases of anxiety (8 or greater). Using Kaplan-Meier survival analysis, patients with depression were less likely to have survived at 6 months than non-depressed patients (50% versus 80%, log rank p=0.01). Baseline anxiety did not appear to impact survival. Using Cox proportional hazard regression analyses to control for stage, ECOG performance status, age, and gender, the effect of depression remained significant at p=0.03. Conclusion: Depression in newly diagnosed advanced NSCLC patients was associated with inferior survival in this well-defined patient population. Conversely, anxiety did not appear to be associated with mortality. These findings strengthen the argument that emotional distress influences survival. Larger prospective studies are needed to confirm this conclusion, explore possible mediators, and investigate the effects of treatment for depression. No significant financial relationships to disclose.