tbuckley/cabot-search huggingface dataset:
The rebound effect of diagnosis of csPCa, after Covid-19 pandemic
Authors: A. Fanelli, U.G. Falagario, F. Guzzi, A. Ninivaggi, L. Montrone, O. Selvaggio, P. Annese, G.M. Busetto, C. Bettocchi, F. Sanguedolce, L. Cormio, G. Carrieri
Journal: European Urology (2024)
Evaluation of the consequences of Direct Current Stimulation (DCS) treatment in patients undergoing robot-assisted radical prostatectomy with nerve-sparing technique
Authors: E. Scarciglia, A. Totaro, M. Campetella, M. Ragonese, D. Nigro, F.P. Bizzarri, F. Gavi, D. Fettucciari, V. Cavarra, A. Cretì, L. Cosenza, F. Bellavia, L. D’Amico, F. Fantasia, F. Marino, G.B. Filomena, S. Vocino, M. Foti, R. Ruocco, D. Sanesi, G. Gulino, E. Sacco, M. Racioppi
Journal: European Urology (2024)
Predictive factors in the success of surgical sperm retrieval techniques
Authors: H. Ayllón, P. Solano, E. Fernández-Pascual, M. Girón, R. Gómez, P. González-Peramato, M.B. Alonso-Bartolomé, A. Yebes, C. Toribio, S. Martínez-Pérez, L. Martínez-Pineiro
Journal: European Urology (2024)
Association of proton pump inhibitors cumulative use with prostate cancer risk and adverse outcomes: A population-based analysis
Authors: R.K. Sayyid, R. Tiwari, B. Zhang, A. Wilton, K. Lajkosz, J. Cockburn, R. Bernardino, M. Al-Rumayyan, Z. Al-Daqqaq, R. Seskin, N.E. Fleshner
Journal: European Urology (2024)
Validation of the PRIMARY system for 68Ga-PSMA-11 PET/CT interpretation for detection of intra-prostatic radiorecurrent prostate cancer
Authors: A. Light, S. Lazic, K. Houghton, M. Bayne, M.J. Connor, N. Mayor, H. Tam, H.U. Ahmed, T.T. Shah, T.D. Barwick
Journal: European Urology (2024)
Revisiting the vascular hitch procedure for crossing vessels in paediatric patients – a longitudinal institutional experience over 15 years
Authors: J. Richter, J. Dos Santos, C. Sánchez, C. Moreno Bernardino, R. Romao, D.T. Keefe, M.E. Chua, M. Rickard, A.J. Lorenzo
Journal: European Urology (2024)
Cancer-derived exosomal prothymosin-α triggers muscle wasting via regulating TLR4-NF-κB-E3 ubiquitin ligase signaling pathway
Authors: C-Y. Hu, C-L. Wu, A-L. Shiau, C-H. Ou, Y-S. Tsai, G-S. Shieh
Journal: European Urology (2024)
Effect of smoking on prostate cancer survivors’ long-term quality of life and function: A longitudinal analysis of the CEASAR (Comparative Effectiveness Analysis of Surgery and Radiation) study
Authors: D-D. Nguyen, D.A. Barocas, L-C. Huang, Z. Zhiguo, T. Koyama, D.F. Penson, M. Goodman, A.S. Hamilton, X-C. Wu, L.E. Paddock, A. Stroup, B.B. O’Neil, K.E. Hoffman, C.J.D. Wallis
Journal: European Urology (2024)
A zebrafish xenograft model for evaluating efficacy of cisplatin in muscle-invasive bladder cancer
Authors: Y. Sugino, S. Sekito, T. Kageyama, T. Sasaki, S. Masui, K. Nishikawa, T. Tanaka, Y. Shimada, L. Zang, T. Inoue
Journal: European Urology (2024)
Cardiac structure and function in men with erectile dysfunction
Authors: E. Durukan, C.F.S.D. Jensen, M. Dons, M. Sengeløv, N.E. Landler, K.G. Skaarup, P.B. Østergren, J. Sønksen, T. Biering-Sørensen, M. Fode
Journal: European Urology (2024)
Hormonal changes following microdissection testicular sperm extraction in men with non-obstructive azoospermia - findings from a real-life multi-centric study
Authors: E. Pozzi, F. Negri, L. Boeri, A. Bertini, F. Belladelli, C. Corsini, M. Raffo, L. Candela, G. Fallara, R. Matloob, A. Sacca’, P. Capogrosso, F. Deho’, A. D’Arma, R. Ramasamy, F. Montorsi, A. Salonia
Journal: European Urology (2024)
Endothelial glycocalyx injury is a risk factor for disseminated intravascular coagulation development in urological sepsis
Authors: N. Fujita, Y. Tobisawa, T. Yoneyama, M. Momota, O. Soma, D. Noro, T. Yoneyama, Y. Hashimoto, K. Yoshikawa, C. Ohyama, S. Hatakeyama
Journal: European Urology (2024)
Outcomes of Robot-Assisted Kidney Transplantation (RAKT) using right vs. left grafts from living donors: Update from the ERUS-RAKT working group
Authors: A. Pecoraro, A. Gallioli, A. Territo, G. Basile, C. Berquin, B. Etcheverry, M. Musuqera, B. Lopez De Mesa Rodriguez, G. Vignolini, T. Prudhomme, A. Volpe, R. Garcia-Baquero, B. Kocak, M. Idu, P. Fornara, M. Rohrsted, A. Alcaraz, N. Doumerc, F. Vigues, K. Decaestecker, S. Serni, A. Breda, R. Campi
Journal: European Urology (2024)
Revealing patterns in spontaneous hemorrhagic risks and growth of angiomyolipomas: Is strict follow-up warranted?
Authors: D. Lopez Curtis, A. Artiles Medina, J.D. Subiela Henríquez, A. Fernández-Mardomingo Díaz, F. González Tello, J. Brasero Burgos, A. Sánchez González, V. Gomez Dos Santos, M.A. Jimenez Cidre, F.J. Burgos Revilla
Journal: European Urology (2024)
Assessment of differences in the Microvessel Density (MVD) and growth factor levels between the inner and outer preputial skin in distal hypospadias
Authors: G. Prasad, A.K. Dhua, S. Kaushal, A. Prabakaran, H. Rathi, P. Goel, S. Agarwala, D.K. Yadav
Journal: European Urology (2024)
Urologists &amp; kidney transplantation: The residents’ perspective
Authors: A. Pecoraro, A. Territo, R. Boissier, V. Hevia, T. Prudhomme, A. Piana, B. Banuelos, L. Afferi, D. Carrion, U. Falagario, A. Goujon, F. Piramide, L. Enrique Ortega Polledo, A. Breda, S. Serni, E. Checcucci, R. Campi
Journal: European Urology (2024)
Analysis of Urinary Tract Infections (UTI) complications after radical cystectomy: Results from a single center study and improvement of ERAS protocol
Authors: V. Lorusso, A. Le Quellec, C. Rion, A. Pacchetti, L. Doisy, F. Lannes, D. Sypre, N. Branger, T. Maubon, S. Rybikowski, A.M. Granata, A. Gregori, G. Pignot, J. Walz
Journal: European Urology (2024)
The role of artificial intelligence for the detection of clinically significant prostate cancer at multiparametric magnetic resonance imaging
Authors: L. Quarta, S. Scuderi, G. Gandaglia, A. Stabile, C. Marzorati, T. Russo, G. Brembilla, E. Camisassa, R. Leni, V. Cucchiara, M. Bianchi, D. Cannoletta, P. Zaurito, F. Barletta, M. Cosenza, D. Robesti, E. Mazzone, F. De Cobelli, F. Montorsi, A. Briganti
Journal: European Urology (2024)
Generation of a new transgenic mouse model to explore the role of oncofetal CRIPTO in lethal prostate cancer
Authors: E. Rodrigues Sousa, S. De Brot, E. Zoni, M. Scarpa, F. La Manna, A. Brunello, A. Abey Alexander, I. Klima, D. Freeman, G. Thalmann, B. Spike, P. Chouvardas, M. Kruithof-De Julio
Journal: European Urology (2024)
Risk factors for kidney cancer and socio-occupational category: Significant impact of chlorinated solvents (ProCCR 111 study)
Authors: M. Ferragu, J.C. Bernhard, A. Fontenil, J. Guillotreau, N. Branger, O. Belas, J-J. Patard, F. Audenet, L. Surlemont, R. Malle, T. Waeckel, P. Bigot
Journal: European Urology (2024)
Prediction of urinary tract infection combining sysmex UF-5000I urine fluorescence flow cytometry with urinalysis – a single center study in Vietnam
Authors: V.A.V. Trang, T.T.T.T. Truyen, N.T.U. Tran, N.H.U. Tran, T.K.H. Dinh, T.T. Huynh, H.G. Le, V.T.V. Huynh, H.T.A. Nguyen, D.B.H. Ho, T.B.N. Le, M.N. Tu, T.K.N. Hong, T.T. Huynh, P.T. Lieu, N.L. Huynh, T.B.N. Dang, T.H.D. Nguyen, M.T. Nguyen, D.T. Doan, P.C.H. Nguyen, V.H. Tran
Journal: European Urology (2024)
Why underrepresentation costs lives: First results from a high-volume multi-institutional study in Germany about risk factors for mortality in Fournier gangrene
Authors: C. Rieger, M. Hübers, D. Pfister, S. Schleifer, J. Hirsch, J. Kranz, B. Gerdes, V. Pantea, A. Chachin, M. Träger, M. Glienke, P. Henniges, M.W. Vetterlein, J. Klemm, F. Roghmann, M. Dellino, U. Jany, M. Tylingr, K. Al Assali, P. Patroi, R. Mayr, S. Engelmann, L. Schneidewind, A. Heidenreich
Journal: European Urology (2024)
The effect of combination treatment with low-intensity shockwave therapy and daily low-dose tadalafil on severe erectile dysfunction: A double-blind, randomized, sham-controlled clinical trial
Authors: D. Kalyvianakis, I. Mykoniatis, N. Pyrgidis, P. Kapoteli, F. Zilotis, D. Hatzichristou
Journal: European Urology (2024)
Can we use immunohistochemistry as predicting factor of successful treatment with intensified neoadjuvant treatment in high-risk prostate cancer: A subanalysis of the ARNEO trial
Authors: A. Giesen, G. Devos, L. Tosco, L. Baekelandt, M. Baldewijns, T. Gevaert, K. Goffin, V. Petit, C. Mai, Y. Raskin, C. Van Haute, L. Goeman, G. De Meerleer, C. Berghen, W. Devlies, F. Claessens, H. Van Poppel, W. Everaerts, S. Joniau
Journal: European Urology (2024)
Mismatch between clinical and pathological T stage among patients with suspected renal cell carcinoma undergoing surgery: Potential implications for target volume delineation and Stereotactic Body Radiotherapy (SBRT) implementation for localized renal masses
Authors: G. Francolini, A. Breda, A. Gallioli, A. Territo, G. Simone, U. Anceschi, M. Marchioni, N. Pavan, S. Erdem, U. Capitanio, F. Montorsi, C. Palumbo, G. Sharma, S.D. Pandolfo, A. Minervini, H. Warren, Z. Wu, C. Ciccarese, E. Roussel, D. Amparore, A. Pecoraro, R. Bertolo, R. Campi
Journal: European Urology (2024)
Association between MRI-detected tumor ADC and risk of 5-year biochemical recurrence after radical prostatectomy
Authors: M.L. Piccinelli, F.A. Mistretta, S. Luzzago, S. Alessi, G. Marvaso, E. Lievore, C. Vaccaro, O. Guglielmo, G. Graps, M. Fontana, R. Bianchi, A. Brescia, D. Bottero, M. Ferro, B.A. Jereczek-Fossa, G. Petralia, G. Musi, O. De Cobelli
Journal: European Urology (2024)
AIRD1A knockouts in bladder cancer cell lines leads to MYC and E2F activation implicated in more aggressive tumor behavior
Authors: C.J. Magnani, V.D. DAndrea, K. Stawiski, I. Stelter, T. Hanlon, L. Jia, A.S. Kibel, M. Mossanen, M.A. Preston, T.N. Clinton, K.W. Mouw, F.L.F. Carvalho
Journal: European Urology (2024)
Ultrasound for the diagnosis of testicular torsion: a systematic review and meta-analysis of diagnostic accuracy
Authors: C.E. Alexander, A. Light, V. Chan, A. Asif, K. Clement, H. Warren, E. Zimmermann, S. Khadouri, P. Eyskens, Y. Takwoingi, P. Sidhu, T. Shah, V. Kasivisvanathan
Journal: European Urology (2024)
A multi-institutional prospective cohort study evaluating mental wellbeing in prostate cancer: The MIND-P Study
Authors: O. Brunckhorst, J. Liszka, C. James, J. Fanshawe, M. Hammadeh, R. Thomas, S. Khan, M. Sheriff, H. Ahmed, M. Van Hemelrijck, G. Muir, R. Stewart, P. Dasgupta, K. Ahmed
Journal: European Urology (2024)
What do patients with Peyronie’s disease expect from therapy? A prospective multi-center study
Authors: L. Schaefer, J. Cremers, B. Witschel, V. Schuettfort, T.O. Nieder, F. Koenig, M.W. Vetterlein, P. Gild, R. Dahlem, M. Fisch, S. Kliesch, A. Soave
Journal: European Urology (2024)
Postoperative recurrence factors in patients with pT3N0M0 clear cell renal cell carcinoma, called the M0 intermediate-high-risk group of the KEYNOTE 564 trial
Authors: H. Naito, O. Homare, I. Ryou, H. Tomoko, O. Yu, A. Yohei, T. Yoichiro, M. Yuki, K. Takuma, T. Rikiya, U. Nobufumi, H. Reiji, S. Mikio
Journal: European Urology (2024)
Quality of information and appropriateness of Open AI outputs for urinary tract infections
Authors: M. Romagnoli, S. Riolo, G. Santoro, R. Lombardo, G. Tema, A. Nacchia, G. Guarnotta, A. Cicione, A. Pastore, Y. Al Salhi, A. Carbone, G. Franco, A. Sciarra, A. Tubaro, C. De Nunzio
Journal: European Urology (2024)
Association between PSMA PET response and oncological outcome following neoadjuvant hormonal therapy in high-risk prostate cancer patients
Authors: G.T. Devos, L. Tosco, M. Baldewijns, A. Giesen, T. Gevaert, K. Goffin, V. Petit, C. Mai, Y. Raskin, C. Van Haute, G. De Meerleer, C. Berghen, W. Devlies, F. Claessens, H. Van Poppel, W. Everaerts, S. Joniau
Journal: European Urology (2024)
Renal allograft management with urolithiasis: A multicentric study. On behalf of the renal transplant group of the Spanish Urological Association
Authors: A. Sierra Del Rio, B. Etcheverry, M. Alvarez-Maestro, J.M. Lopez, M. Fiol, C. Torrecilla, F. Vigués, C. Martinez, E. Carbonell, S. Martinez-Perez, A. Alcaraz, M.P. Luque, M. Musquera
Journal: European Urology (2024)
Oncological impact of perioperative blood transfusion in bladder cancer patients undergoing radical cystectomy: Do we need to consider storage time of blood units, donor age or gender matching?
Authors: B. Ebner, F. Franka, Y. Volz, L. Eismann, J. Hermans, A. Buchner, B. Enzinger, P. Weinhold, C. Wichmann, C.G. Stief, A. Humpe, N. Pyrgidis, G.B. Schulz
Journal: European Urology (2024)
Temporal trends in urinary diversion among patients undergoing radical cystectomy from 1986 to 2022: Single-center evaluation of 2,224 cases
Authors: G. Duwe, C. Wiesmann, K.E. Banasiewicz, I. Wagner, N.D. Fischer, L.J. Frey, M. Haack, R. Mager, T. Höfner, P. Sparwasser, I. Tsaur, M.M. Kamal, C. Thomas, M.P. Brandt, A. Haferkamp
Journal: European Urology (2024)
Shifting the paradigm: Improving renal cell carcinoma staging within the AJCC system by adding C-reactive protein-analysis of the INMARC Registry
Authors: C. Saitta, J. Afari, B. Lane, H. Tanaka, D. Patil, K. Yuen, J. Cortes, M. Mahmood, J. Matian, M. Mansour, K. Hakimi, L. Wang, M. Meagher, M. Nguyen, D. Puri, E. Nicaise, I. Nahar, R. Greenwald, C. Cerrato, M. Kobayashi, S. Fukuda, Y. Fujii, V. Master, I. Derweesh
Journal: European Urology (2024)
Utility of intravenous indocyanine green to evaluate distal ureteral vascularity during robot-assisted radical cystectomy with intracorporeal urinary diversion
Authors: E. Carbonell, M. Muní, C. Martínez, H. Alfambra, R. Pagès, E. Villalba, M. Peradejordi, A. Tello, C. Mercader, A. Sierra, A. Vilaseca, M.J. Ribal, A. Alcaraz, M. Musquera, R. Martos
Journal: European Urology (2024)
Role of serum immunoglobulin N-glycans in endothelial glycocalyx injury in urological sepsis
Authors: N. Fujita, T. Yoneyama, Y. Tobisawa, M. Momota, O. Soma, D. Noro, T. Yoneyama, Y. Hashimoto, C. Ohyama, S. Hatakeyama
Journal: European Urology (2024)
MRI-Targeted biopsy in biopsy-naïve patients and the risk of overtreatment: A grading issue
Authors: T. Jabbour, A. Peltier, L. Rocq, N. Sirtaine, Y. Lefebvre, H.A. Bourgeno, A. Baudewyns, T. Roumeguere, R. Diamand
Journal: European Urology (2024)
Prognostic significance of body mass index in patients with metastatic renal cell carcinoma treated with first-line therapies
Authors: K. Sato, K. Takemura, R. Oki, T. Urasaki, Y. Yoneoka, R. Fujiwara, Y. Yasuda, T. Oguchi, N. Numao, S. Yamamoto, J. Yonese, T. Yuasa
Journal: European Urology (2024)
Incidental prostate cancer in patients treated for benign prostatic hyperplasia: Analysis from a contemporary national dataset
Authors: E. Bologna, L.C. Licari, A. Franco, F. Ditonno, C. Manfredi, C. De Nunzio, A. Antonelli, M. De Sio, C. Leonardo, L. Cindolo, E.E. Cherullo, R. Autorino
Journal: European Urology (2024)
Development and validation of prognostic nomograms and integrated software incorporating preoperative CRP level for predicting survival outcomes in patients with nonmetastatic clear cell renal cell carcinoma: INMARC study
Authors: W. Chen, H. Tanaka, M. Kobayashi, S. Fukuda, A. Nakayama, M. Meagher, R. Greenwald, B. Schmeusser, Y. Waseda, S. Yoshida, I.H. Derweesh, V.A. Master, Y. Fujii, K. Saito
Journal: European Urology (2024)
An exploratory clinical trial of alginate gel combined with polyglycolic acid nerve sheets for restoring erectile function following cavernous nerve injury during radical prostatectomy
Authors: N. Narita, M. Kobayashi, S. Kashima, R. Yamamoto, N. Kazuyuki, Y. Sekine, H. Sato, M. Saito, Y. Suzuki, T. Habuchi
Journal: European Urology (2024)
Enzalutamide (enza) with or without leuprolide in patients (pts) with European Association of Urology (EAU)-guideline-defined high-risk BioChemically Recurrent prostate cancer (BCR) following Radical Prostatectomy (RP) or Radiation Therapy (RT): EMBARK post hoc analysis
Authors: U. De Giorgi, S.J. Freedland, A. Rannikko, M. Ramirez-Backhaus, A. Villers, M. Gleave, J. Tarazi, Y. Tang, G.P. Haas, M. Rosales, N.D. Shore
Journal: European Urology (2024)
Stage-specific survival among men with prostate cancer in the Nordic countries 2004-2016 - the NORDCAN survival studies
Authors: S.B. Larsen, F.E. Lundberg, S. Friis, H. Birgisson, T.M.L. Andersson, G. Engholm, P.C. Lambert, M. Lambe, D. Pettersson, E. Ólafsdóttir, T.B. Johannesen, S.M. Kønig, A.L.V. Johansson, L.S. Mørch
Journal: European Urology (2024)
Combined analysis of molecular patterns and clinical factors for the prediction of immune checkpoint inhibitor therapy in advanced urothelial carcinoma
Authors: T. Szarvas, M. Varadi, O. Horvath, E. Soos, T. Fazekas, A. Csizmarik, B. Nemeth, B. Gyorffy, I. Kenessey, H. Reis, F. Koll, C. Olah, B. Hadaschik, U. Krafft, F. Mairinger, M. Wessolly, M. Hoffmann, C. Grunewald, G. Niegisch, A. Maraz, L. Kuthi, A. Furka, P. Nyirady
Journal: European Urology (2024)
Asymptomatic bacteriuria prior to partial and radical nephrectomy: To screen or not to screen?
Authors: E. Ayoub, S. Kutchukian, A. DINH, P. Bigot, H. Robin, S. Bernardeau, H. Ducousso, B. Gondran-Tellier, M. Françot, S. DE VERGIE, M. Chapuis, L. Brureau, E. Lechevallier, B. Poussot, S. Borojeni, F. Kosseifi, M. Gaullier, T. Thibault, M. Baboudjian, J. Rigaud, O. Karray, A. DESCAZEAUD, F. Bruyère, M. Vallée
Journal: European Urology (2024)
Midlife baseline PSA as a predictor of lethal prostate cancer: Racial differences between black and white men
Authors: G. Chiarelli, M. Davis, A. Stephens, M. Finati, G. Cirulli, C. Morrison, A. Sood, G. Carrieri, A. Briganti, F. Montorsi, G. Lughezzani, N. Buffi, C. Rogers, F. Abdollah
Journal: European Urology (2024)
Commonality and variation in mental representations of music revealed by a cross-cultural comparison of rhythm priors in 15 countries
Authors: Nori Jacoby, Rainer Polak, Jessica A. Grahn, Daniel J. Cameron, Kyung Myun Lee, Ricardo Godoy, Eduardo A. Undurraga, Tomás Huanca, Timon Thalwitzer, Noumouké Doumbia, Daniel Goldberg, Elizabeth H. Margulis, Patrick C. M. Wong, Luis Jure, Martín Rocamora, Shinya Fujii, Patrick E. Savage, Jun Ajimi, Rei Konno, Sho Oishi, Kelly Jakubowski, Andre Holzapfel, Esra Mungan, Ece Kaya, Preeti Rao, Mattur A. Rohit, Suvarna Alladi, Bronwyn Tarr, Manuel Anglada-Tort, Peter M. C. Harrison, Malinda J. McPherson, Sophie Dolan, Alex Durango, Josh H. McDermott
Journal: Nature Human Behaviour (2024)

Abstract Music is present in every known society but varies from place to place. What, if anything, is universal to music cognition? We measured a signature of mental representations of rhythm in 39 participant groups in 15 countries, spanning urban societies and Indigenous populations. Listeners reproduced random ‘seed’ rhythms; their reproductions were fed back as the stimulus (as in the game of ‘telephone’), such that their biases (the prior) could be estimated from the distribution of reproductions. Every tested group showed a sparse prior with peaks at integer-ratio rhythms. However, the importance of different integer ratios varied across groups, often reflecting local musical practices. Our results suggest a common feature of music cognition: discrete rhythm ‘categories’ at small-integer ratios. These discrete representations plausibly stabilize musical systems in the face of cultural transmission but interact with culture-specific traditions to yield the diversity that is evident when mental representations are probed across many cultures.
Abstract A030: Regulation of SIRT3 overexpression in anchorage independent ovarian cancer
Authors: Sneha Srinivasan, Priscilla Tang, Karthikeyan Mythreye, Nadine Hempel
Journal: Cancer Research (2024)

Abstract Ovarian cancer remains the most lethal gynecological malignancy, and late-stage diagnosis and significant metastatic spread are prominent contributors to its lethality. To achieve optimal metastasis, ovarian tumor cells must modify their response to heightened oxidative stress to ensure their survival. One crucial mechanism of this modification involves the scavenging of mitochondrial superoxide anions by superoxide dismutase (SOD2). Mitochondrial Sirtuin Deacetylase 3 (SIRT3) deacetylates SOD2 to enhance its antioxidant capacity, facilitating the conversion of superoxide (O2−) to H2O2. We have shown that this antioxidant mechanism helps to preserve mitochondrial function of high grade serous ovarian cancer cell lines, enhances cellular survival in anchorage-independence, and is necessary for in vivo metastatic spread to the omentum. Expression of both SOD2 and SIRT3 increase in ovarian cancer cells following matrix detachment, and we found that SOD2 is regulated by both transcription and translation, resulting in rapid and sustained increases in this mitochondrial antioxidant in response to matrix detachment. Presently, we are exploring the mechanisms of SIRT3 regulation, as this deacetylase is necessary for the maintenance of SOD2 activity in anchorage independent conditions. We find that active transcription is required for the increased SIRT3 expression observed in anchorage independence and are currently investigating the role NF-kB plays as a critical transcription factor of SIRT3 in this context. Understanding the regulation of SIRT3 will shed light on ovarian cancer cell survival adaptations during metastasis and provide potential insights into new targets for therapeutic interventions. Citation Format: Sneha Srinivasan, Priscilla Tang, Karthikeyan Mythreye, Nadine Hempel. Regulation of SIRT3 overexpression in anchorage independent ovarian cancer [abstract]. In: Proceedings of the AACR Special Conference on Ovarian Cancer; 2023 Oct 5-7; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(5 Suppl_2):Abstract nr A030.
Is adjuvant immunotherapy following cystectomy a bandage for inadequate surgery?
Authors: E. Kjøbli, Ø. Salvesen, B. Gharib-Alhaug, G. Gudbrandsdottir, A-K. Karlsvik, G. Lilleaasen, M. Larsen, M. Roaldsen, S. Mueller, E.S. Haug, C. Beisland
Journal: European Urology (2024)
The impact of exposure to ileal feces during intracorporeal urinary diversion: Cultivable microbiota of the distal ileum
Authors: K. Zennami, T. Nukaya, K. Ishikawa, M. Takenaka, M. Ichino, K. Takahara, H. Sasaki, M. Kusaka, M. Sumitomo, R. Shiroki
Journal: European Urology (2024)
Abstract A036: Nanoparticle targeting in platinum-resistant ovarian cancer reveals dual axis of therapeutic vulnerability involving cholesterol uptake and cell redox balance
Authors: Yinu Wang, Andrea Calvert, Cardenas Horacio, Fukai Chen, Russell Keathley, Ji-Xin Chen, Shad Thaxton, Daniela Matei
Journal: Cancer Research (2024)

Abstract Platinum (Pt) is the main therapy for ovarian cancer (OC); however, most patients develop Pt resistance (Pt-R). We show that Pt-R OC cells increase intracellular cholesterol through uptake via the HDL receptor, scavenger receptor type B-1 (SR-B1). SR-B1 blockade using synthetic cholesterol-poor HDL-like nanoparticles (HDL NPs) diminished cholesterol uptake leading to cell death and suppressed tumor growth. Reduced cholesterol accumulation induced lipid oxidative stress through reduction of glutathione peroxidase 4 (GPx4) leading to ferroptosis. In turn, GPx4 depletion is associated with reduced cholesterol uptake and re-sensitized OC cells to Pt. Mechanistically, GPx4 knockdown induced decreased expression of EP300, leading to reduced H3K27Ac on the SREBP2 promoter. Suppressed SREBP2 caused the downregulation of SR-B1. Thus, chemoresistance and cancer cell survival under a high ROS burden obligate high GPx4 and SR-B1 expression through SREBP2. Targeting SR-B1 to modulate cholesterol uptake inhibits this axis and causes ferroptosis in vitro and in vivo in Pt-R OC. Citation Format: Yinu Wang, Andrea Calvert, Cardenas Horacio, Fukai Chen, Russell Keathley, Ji-Xin Chen, Shad Thaxton, Daniela Matei. Nanoparticle targeting in platinum-resistant ovarian cancer reveals dual axis of therapeutic vulnerability involving cholesterol uptake and cell redox balance [abstract]. In: Proceedings of the AACR Special Conference on Ovarian Cancer; 2023 Oct 5-7; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(5 Suppl_2):Abstract nr A036.
The Portuguese Navy Radiation-induced Cystitis (PNRC) scale: Validation of a novel clinical radiation-induced cystitis classification
Authors: T.M. Ribeiro De Oliveira, S. Henriques Pereira, C. D Espiney Amaro, A. Sousa Castro, P. Gomes Monteiro, J. Cardoso Felicio, C.S. Biyani
Journal: European Urology (2024)