THE BLOOD PRESSURE REDUCING PROPERTY OF EXTRACTS OF KIDNEYS IN HYPERTENSIVE PATIENTS AND ANIMALS
Authors: Irvine H. Page, O. M. Helmer, K. G. Kohlstaedt, G. F. Kempf, W. D. Gambill, R. D. Taylor
Journal: Annals of Internal Medicine (1941)

Article1 September 1941THE BLOOD PRESSURE REDUCING PROPERTY OF EXTRACTS OF KIDNEYS IN HYPERTENSIVE PATIENTS AND ANIMALSIRVINE H. PAGE, M.D., O. M. HELMER, Ph.D., K. G. KOHLSTAEDT, M.D., G. F. KEMPF, M.D., W. D. GAMBILL, M.D., R. D. TAYLOR, M.D.IRVINE H. PAGE, M.D., O. M. HELMER, Ph.D., K. G. KOHLSTAEDT, M.D., G. F. KEMPF, M.D., W. D. GAMBILL, M.D., R. D. TAYLOR, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-3-347 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt1. Tigerstedt and Bergmann1 demonstrated that bilateral nephrectomy increases the rise in arterial pressure occurring in anesthetized animals when extracts of kidney containing renin are injected into them. This observation was confirmed by Merrill, Williams and Harrison,2 and by Fasciolo, Houssay and Taquini3 who suggested that the increased sensitivity might be due to loss of an anti-pressor substance. Similar increase in sensitivity was observed by Page and Helmer4 when angiotonin was administered instead of renin. Angiotonin is the pressor substance resulting from interaction of renin and renin-activator.5Nephrectomy therefore appears to remove the source of some substance which opposes the...Bibliography1. TIGERSTEDTBERGMANN RPG: Niere und Kreislauf, Skand. Arch. f. Physiol., 1898, viii, 223. CrossrefGoogle Scholar2. MERRILLWILLIAMSHARRISON ARHTR: The effects of a pressor substance obtained from the kidneys on the renal circulation of rats and dogs, Am. Jr. Med. Sci., 1938, cxcvi, 240. CrossrefGoogle Scholar3. FASCIOLOHOUSSAYTAQUINI JCBAAC: The blood pressure raising secretion of the ischemic kidney, Jr. Physiol., 1938, xciv, 281. CrossrefGoogle Scholar4. PAGEHELMER IHOM: Angiotonin-activator, renin and angiotonin inhibitor and the mechanism of angiotonin tachyphylaxis in normal, hypertensive and nephrectomized animals, Jr. Exper. Med., 1940, lxxi, 495. CrossrefGoogle Scholar5. 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POUTASSE, M.D.Herz und KreislaufDie Klinik und Chemie der Proteinasen des menschlichen und tierischen Organismus, ihre besondere Bedeutung in seinen Abwehrleistungen und in der klinischen DiagnostikVASOCONSTRICTORS IN THE COMMON COLDPENICILLIN IN RHEUMATIC FEVERRENAL EXTRACTS IN HYPERTENSIONThe Treatment of HypertensionArterial Hypertension 1 September 1941Volume 15, Issue 3Page: 347-389KeywordsBlood pressureClinical laboratoriesKidneysNephrectomyResearch laboratories ePublished: 1 December 2008 Issue Published: 1 September 1941 Copyright & PermissionsCopyright, 1941, by The American College of PhysiciansPDF downloadLoading ...