tbuckley/cabot-search huggingface dataset:
Supplemental Security Income and the sick role
Authors: H R Lamb, A S Rogawski
Journal: American Journal of Psychiatry (1978)

Supplemental Security Income (SSI) has given the psychiatrically disabled a dependable source of income and helped make it possible for them to live outside state hospitals. The change to SSI has had an important effect on delabeling and decreasing the stigma of receiving Aid to the Disabled. However, the secondary gain inherent in SSI may interfere with social and vocational rehabilitation efforts. The authors present recommendations aimed at making the SSI system more conducive to social integration and rehabilitation.
Abstract 15185: Effects of Age and Exercise Training on Ventilatory Efficiancy in Chronic Heart Failure
Authors: Marcus Sandri, Norman Mangner, Jonathan Myers, Stephan Gielen, Gerhard Schuler
Journal: Circulation (2014)

Introduction: Parameters of ventilatory efficiency like the VE/VCO2slope and the Oxygen Uptake Efficiancy Slope (OUES) have recently been shown to be of high prognostic value in patients with advanced chronic heart failure. However, there is a paucity of data, whether those parameters can be positively altered by established interventions in CHF like exercise training and if potential beneficial training effects are diminished in older patients. Methods: 60 CHF patients and 60 age-matched referent controls were randomized to 4 weeks of bicycle ergometer training at 70% of the heart rate reserve 4 x 20 min/day or to a control group (C). Before and after the intervention a cardiopulmonary exercise test was performed and parameters of ventilatory efficiency were calculated. Results: Training Effects: In younger CHF patients (n= 15, age 45±3 years, BMI 26.8±2.7, LV-EF 26.8±2.6%) training improved the VE/VCO2slope from 41.3±3.6 to 35.1±3.2 (p=0.004 vs. control) and the OUES from 1472±287 to 1783±196 (p = 0.003...
Evidence for enhanced inflammatory cell activity, ICAM-1 expression and eosinophil chemotactic activity in the sputum of asthmatics.
Authors: Renaud Louis, J. Shute, S. Biaggi, L. Stanciu, F. Marelli, H. Tenor, R. Hidi, R. Djukanovic
Journal: American Journal of Respiratory and Critical Care Medicine (1997)
Trastuzumab insensitivity despite HER-2 receptor down-regulation and internalization in a novel cell line established from a Herceptinresistant breast cancer patient.
Authors: A. I. Kapanen, M. Tanner, T. Junttila, P. Nagy, K. Elenius, R. Karhu, S. Grenman, J. Elo, J. Isola
Journal: Clinical Cancer Research (2003)
O-iodoxybenzoic Acid in the Treatment of Infectious Arthritis; Report of Eighty Additional Cases
Authors: John B. Youmans
Journal: Annals of Internal Medicine (1928)

Article1 January 1928O-iodoxybenzoic Acid in the Treatment of Infectious Arthritis; Report of Eighty Additional CasesJOHN B. YOUMANS, M.D.JOHN B. YOUMANS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-7-494 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous communication (1) A. G. Young and the author reported the results obtained in a series of forty-three patients with infectious arthritis treated with O-iodoxybenzoic acid. Since then Smith (2) has reported his results with the drug in a series of thirty-three patients. The present paper is a study of eighty additional cases treated at the University Hospital since the first report and includes all patients who have been under observation for a period sufficiently long to warrant an estimate of the amount of improvement gained. All of them have been under observation for a period of at...Bibliography(1) YOUNGYOUMANS AJJB: The Use of O-iodoxybenzoic Acid in the Treatment of Infectious Arthritis, J. A. M. A. 87:746. (Sept. 4) 1926. CrossrefGoogle Scholar(2) SMITH M: The Use and Action of O-iodoxybenzoic Acid in the Treatment of Arthritis, Bost. M. and S. Journal. 196:305 (Feb. 24) 1927. CrossrefGoogle Scholar(3) ID.:The Use and Action of O-iodoxybenzoic Acid, Boston M. and S. Journal 196-540 (Mar. 31) 1927. Google Scholar(4) HEKTOEN L: Proc. Chicago Path. Soc. 8:138, 1911. Google Scholar(5) ARKIN A: The Influence of Certain Oxidizing Agents (Sodium Iodosobenzoate and Sodium Iodoxybenzoate) on Phagocytosis, J. Infect. Disease 11: 427, 1912. ID: The Influence of an Oxidizing Substance (Sodium Iodoxybenzoate) on Immune Reactions, Infect. Disease. 16:349. 1926. CrossrefGoogle Scholar(6) PEMBERTON R: The Etiology and Pathology of Arthritis, J. A. M. A. 87:1253 (Oct. 16) 1926. CrossrefGoogle Scholar(7) TRAUBA NC: O-iodoxybenzoic Acid in Treatment of Chronic Arthritis. J. A. M. A. 89:1124 (Oct. 1) 1927. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nashville, Tennessee*From the Department of Internal Medicine, University of Michigan Medical School, Ann Arbor. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by2-Iodoxybenzoesäure - ein einfaches Oxidationsmittel mit einer Vielfalt an Anwendungsmöglichkeiten2-Iodoxybenzoic Acid-A Simple Oxidant with a Dazzling Array of Potential Applications 1 January 1928Volume 1, Issue 7Page: 494-505KeywordsArthritisDrugs ePublished: 1 December 2008 Issue Published: 1 January 1928 PDF downloadLoading ...
Abstract 3980: Nanoparticle Based Delivery of Hypoxia Regulated VEGF Transgene System Combined With SkMs Engraftment: A Safer Approach to Treat Ischemic Cardiomyopathy
Authors: Lei Ye, Wei Zhang, LiPing Su, Husnain K Haider, Kian K Poh, Mary J Galupo, Geronica Songco, Huay C Tan, Eugene K Sim
Journal: Circulation (2009)

Objective: Regulated promoter system consented to tightly controlled gene expression is desirable for safe and efficacious overexpression of therapeutic transgenes. Combined with skeletal myoblast ...
Role of Glucocorticoid Receptors in Intracranial Tumors
Authors: Giorgio Butti, Carlo Zibera, Massimo Scerrati, Gigliola Sica, Nadia Gibelli, Lorenzo Magrassi, Marilena Rolli, Gabriele Introzzi, Gianfranco Rossi, Gioacchino Robustelli della Cuna
Journal: Neuro-Oncology (1991)

Glucocorticoids, mainly dexamethasone (Dex) and methylprednisolone (Mp) are widely used as supportive therapy in the management of intracranial tumors. Their action on cells depends, in part, on the presence of a specific intracellular receptor (glucocorticoid receptor, GR) that binds the hormone leading to a sequence of biological events. In this study, we evaluated the presence of GR and its biological role in neuroepithelial tumors. Tumoral samples from 25 glioblastomas, 18 anaplastic astrocytomas and 14 astrocytomas were analyzed. Glucocorticoid specific binding proteins were detected in 38.6% of the cases using the dextran-coated charcoal method. A correlation was found between grade of anaplasia, sex, and GR positivity. The biological role of this receptor was investigated in 11 primary cell cultures derived from neuroepithelial tumors. For this purpose, different concentrations of Dex and Mp were added to the culture medium. When Dex doses ranging from 2 to 0.016 μg/ml were utilized, a significant stimulation of the cell growth was observed in receptor positive cultures. At the same doses, no modulation of the cell growth was observed in receptor negative cultures. Same responses were obtained when Mp was added to the culture medium.
Spontaneous remission of MAOI-induced anorgasmia
Authors: H G Nurnberg, P E Levine
Journal: American Journal of Psychiatry (1987)

The authors present three case reports illustrating that a conservative approach to anorgasmia induced by effective treatment with the monoamine oxidase inhibitor (MAOI) phenelzine can result in spontaneous remission. Precipitously stopping phenelzine or adding another medication to counteract the side effect can be avoided. The apparent synchrony between the development of the side effect of anorgasmia and positive treatment response may represent a valuable clinical marker.
TV: A prayer from the dying
Authors: J. Anderson
Journal: BMJ (1999)

June Burns, a 59 year old woman with terminal bladder cancer, wants to die before her pain becomes unbearable. In an attempt to persuade others of her right to die as she chooses, she has appeared on Australian television in an advertisement sponsored by the Voluntary Euthanasia Society of New South Wales.

The advertisement features Mrs Burns speaking from her hospital bed, appealing for legal sanction to kill herself. “If I was a dog, by now the RSPCA would be on to my husband for cruelty and would have me put down straight away,” she says. “I feel life is very precious and I've enjoyed every moment of it and I wish I could go on, but I can't and I'd like to die with dignity.”

The advertisement has had a major impact both on the public and on Mrs Burns. Carmel Marjenberg, coordinator of the …
PIM3-SCO2 Fusion Is a Novel Transcription-Induced Chimera That Is Highly Prevalent In Childhood AML
Authors: Julia Kuhn, Daoud Meerzaman, Rhonda E. Ries, Filippo Milano, Alan S. Gamis, Todd A. Alonzo, Jaime Guidry-Auvil, Tanja M. Davidsen, Malcolm A. Smith, Yan Chunhua, Chih Hao Hsu, Cu Nguyen, Daniela S. Gerhard, Daniel Wai, Robert J. Arceci, Soheil Meshinchi
Journal: Blood (2013)
Abstract 5598: Notch Signaling in Intrinsic Stem Cell is a Prerequisite for Therapeutic Angiogenesis
Authors: Kaoru Tateno, Tohru Minamino, Issei Komuro
Journal: Circulation (2009)

Cell transplantation became a prevalent method to induce therapeutic angiogenesis for patients with ischemic burden. However, its mechanism has been a matter of debate. We previously reported that therapeutic limb angiogenesis by peripheral blood mononuclear cells (PBMNC) transplantation was accomplished through enhancement of muscle regeneration process, which essentially coincides with massive production of angiogenic growth factors. Here, we show that Notch signaling in skeletal myoblasts is critical to initiate this therapeutic process. PBMNC instantly induced robust proliferation of interstitial cells in ischemic tissue. In sections, majority of these cells stained double-positive for myoblast markers and activated Notch-1 receptor. Production of cytokines and myogenic growth factors by host tissue, and subsequent recruitment of activated macrophages, were also observed as acute effects after PBMNC transplantation, and was shown to be crucial for adequate muscle regeneration and angiogenesis in the later phase. Such beneficial effects by PBMNC were abolished in myoblast null Pax7 knockout mice, indicating a critical role of intrinsic stem cells in therapeutic angiogenesis. Importantly, treatment of wild type ischemic host with a Notch inhibitor markedly reduced the ratio of myoblasts among the proliferating interstitial cells, resulting in severe impairment of both acute and late-phase effects by PBMNC transplantation. Notch-1 conditional knockout mice showed similar results after PBMNC transplantation, further confirming the importance of host Notch signaling. Interestingly, deletion of a Notch ligand Jagged-1 from the donor PBMNC resulted in marked attenuation of muscle regeneration and neovascularization. Conversely, over expression of Jagged-1 in the implanted cells significantly increased the efficacy of this treatment. Taken together, we conclude that activation of Notch signaling in myoblasts is crucial for tissue regeneration by cell therapy. Additionally, we provide a model showing that activation of intrinsic stem cells, through exogenous introduction of Notch ligands, could be a novel strategy to enhance tissue regeneration in a therapeutic context.
THE EFFECT ON THE PRECORDIAL ELECTROCARDIOGRAM OF INSULATING AREAS OF THE ANTERIOR CHEST WALL
Authors: A H DOUGLAS, J S KALTER
Journal: Annals of Internal Medicine (1949)

Article1 April 1949THE EFFECT ON THE PRECORDIAL ELECTROCARDIOGRAM OF INSULATING AREAS OF THE ANTERIOR CHEST WALLALBERT H. DOUGLAS, M.D., F.A.C.P., JERALD S. KALTER, M.D.ALBERT H. DOUGLAS, M.D., F.A.C.P.Search for more papers by this author, JERALD S. KALTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-4-799 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe precordial leads have justifiably gained increasing importance in the past decade and considerable knowledge has accumulated concerning the significance of the various deflections in the standard positions. These leads are now used routinely to supplement the information given by the limb leads and, more particularly, to aid in the localization of myocardial infarcts, bundle branch block, and pathologic processes involving primarily the right or the left side of the heart. The localizing value of precordial leads results from the well known fact1 that an exploring electrode on theanterior chest wall produces an electrocardiogram which resembles that of the...Bibliography1. WILSONJOHNSTONROSENBAUMHECHTCOTRINBARKERSCARSIDE OLIVEIRA FNFDHEHNPSRRM: The precordial electrocardiogram, Am. Heart Jr., 1944, xxvii, 27, 19. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication February 19, 1948.From the Heart Station at the U. S. Naval Hospital, St. Albans, N. Y.The opinions or assertions contained herein are the private ones of the writers and are not to be construed as official or reflecting the views of the Navy Department or the naval service at large. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1949Volume 30, Issue 4Page: 799-809KeywordsElectrocardiographyHeartMyocardial infarctionPharmacistsThorax ePublished: 1 December 2008 Issue Published: 1 April 1949 PDF downloadLoading ...
Triphasic waveforms are superior to biphasic waveforms for transthoracic defibrillation
Authors: Yi Zhang, R.S Ramabadran, Kimberly A Boddicker, Imran Bawaney, Loyd R Davies, M.Bridget Zimmerman, Scott Wuthrich, Janice L Jones, Richard E Kerber
Journal: Journal of the American College of Cardiology (2003)
Socioeconomic status, ethnicity, psychological distress, and readiness to utilize a mental health facility
Authors: D F Briones, P L Heller, H P Chalfant, A E Roberts, S F Aguirre-Hauchbaum, W F Farr
Journal: American Journal of Psychiatry (1990)

The effects of minority status versus ethnic culture on Mexican-Americans' underutilization of mental health services were reassessed through development and testing of an analytic path model that proposes a sequence of factors, including Mexican-American ethnicity, socioeconomic status, degree of social and institutional support, and depression, which culminate in a person's decision to utilize mental health facilities. The model also predicts that life stress will affect utilization through its influence on depression. Data from 783 subjects generally supported the model's predictions. A multifactorial approach to the causes of mental health problems and utilization behavior in the Mexican-American population is suggested.
Abstract 11202: Enoxaparin is More Efficient Than Unfractionated Heparin Considering the Safety and Cost-effectiveness for Bridgy Therapy in Patients With Mechanical Heart Valves During Invasive Dental Procedures
Authors: K-Bum Won, Seung-Hyun Lee, Hyuk-Jae Chang
Journal: Circulation (2013)

Introduction: Invasive dental procedures have the risk of excessive bleeding with regard to highly vascular supporting structures in patients with mechanical heart valves (MHV) receiving warfarin t...
Why intensivists continue disproportional patient care, results from the APPROPICUS study
Authors: R. Pier, Elie Azoulay, Bara Ricou, F. DeKeyser, Johan Decruyenaere, Adeline Max, Andrej Michalsen, Pieter Depuydt, Radoslaw Owczuk, P. Azavedo Maia, Francesca Rubulotta, Anna K Reyners, Anne-Pascale Meert, Andrew Aquilina, Dominique Benoit
Journal: Intensive Care Medicine (2011)
Effects of pantoperazole on pulmonary function tests of chronic obstructive pulmonary disease patients, with and without gastro esophageal reflux
Authors: Farhad Malek, Raheb Ghorbani, Fatemeh Yaghobi
Journal: European Respiratory Journal (2011)

Introduction:  Association between gastro esophageal reflux (GERD) and spirometric finding in chronic obstructive pulmonary disease (COPD) is subject of controversy. The aim of this investigation is to determine the effect of proton pump inhibitor (pantoprazole) on spirometric finding of COPD patient.   Material & method:  In this clinical trial, 60 COPD patients were selected and according to questionnaire divide in two groups: with and without GERD (36 and 24 patient respectively). All patient treated with oral pantoprazole 40 mg daily for eight weeks. Spirometry before and after treatment was done. FEV1/FVC, FEV1, FVC, PEF were measured in two groups.   Result:  Mean PEF in COPD patients with GERD before (55.4) and after pantoprazol had significant difference (55.4, 61.5 respectively) (p = 0.009) but mean FEV1/FVC, FEV1, FVC in both groups and PEF in patients without GERD had no significant difference.   Conclusion:  This study showed in COPD patient with GERD, treatment with 40mg pantoprazole daily improve PEF but has no effect on other spirometric parameters.
Stem cell based therapies for age-related macular degeneration: The promises and the challenges
Authors: Hossein Nazari, Li Zhang, Danhong Zhu, Gerald J. Chader, Paulo Falabella, Francisco Stefanini, Teisha Rowland, Dennis O. Clegg, Amir H. Kashani, David R. Hinton, Mark S. Humayun
Journal: Progress in Retinal and Eye Research (2015)
Abstract 16876: Changes in Population Attributable Fraction of Acute Coronary Syndrome Due to Diabetes in Finland During 1992 - 2002
Authors: Klas Winell, Arto Pietila, Veikko Salomaa
Journal: Circulation (2010)

Introduction: Acute coronary syndrome (ACS) event rates are decreasing in many countries, mainly due to better control of risk factors. At the same time, the prevalence of diabetes is increasing. D...
"Subconsultant" posts are increasing dramatically
Authors: P E Robin
Journal: BMJ (1995)

EDITOR,—The declared intent of both the government and the medical profession is the expansion of the consultant grade1 2 3; Plan for Action proposed the mechanisms for this.2 The staff grade was a response to the need for a non-consultant or subconsultant career grade. Concern that this grade might develop was evident in the joint agreement that the number in the staff grade should not exceed 10% of the number of consultants. The table shows that the annual increase in consultant posts was …
Abstract 973: A Novel Anti-Inflammatory Therapeutic Approach for Pulmonary Arterial Hypertension: Blockade of NF-kB by Nano-DDS of NF-kB decoy to the lung ameliorates monocrotaline-induced PAH
Authors: Satoshi Kimura, Kensuke Egashira, Chen Ling, Hiroyuki Tsujimoto, Kaori Hara, Yoshiaki Kawashima, Ryuji Tominaga, Kenji Sunagawa
Journal: Circulation (2007)

Background: Inflammatory mechanisms are implicated in the pathogenesis of pulmonary arterial hypertension (PAH), and thus can be a promising therapeutic target of the devastating disease. Nuclear factor-κB (NF-κB) is a redox-sensitive transcription factor that controls expression of important inflammatory cytokines. However, no prior study addressed the role of NF-κB in PAH. We have developed nanotechnology-based drug delivery system (Nano-DDS) to the lung using intratracheal injection of bioabsorbable polymeric PLGA nanoparticle (NP, a mean diameter of 50 nm) for clinical application. Hypothesis: Blockade of NF-κB by Nano-DDS of NF-κB decoy to the lung ameliorates monocrotaline (MCT)-induced PAH. Methods and Results: [Immunohistochemical studies in human samples from autopsy] Immunohistochemical study using an antibody against activated form (α-p65) showed that activation of NF-κB was noted in the alveolar macrophage and pulmonary vasculature with medial hypertrophy from lung cross-sections from patients with severe PAH. These pathologic changes were associated with increased staining of IL-6 and MCP-1. [Experimental animal studies] Single intratracheal injection of NP incorporated with fluorescence labeled NF-κB decoy in rats resulted in sustained intracellular delivery into macrophages and pulmonary vasculature until 7 days. After MCT injection, rats were divided into no treatment (No Tx) group, and those received single intratracheal decoy alone (50 μg), blank NPs alone, or decoy NP (n=6 – 8, each). No Tx group developed significant PAH, pulmonary arterial remodeling, and increased infiltration of macrophages 3 weeks after MCT injection. These pathologic changes were ameliorated by treatment with decoy NP, but not with decoy only or blank NP only. Increased activity of NF-κB in alveolar macrophages in No Tx group was attenuated by intratracheal decoy NP, but not by decoy only or blank NP only. Conclusions: We have developed a novel Nano-DDS of NF-κB decoy into the lung using bioabsorbable NP, and demonstrated its therapeutic benefit associated with anti-inflammatory effects in MCT-induced PAH. This study provides an innovative future direction of less invasive and dependable Nano-DDS for patients with severe PAH.
Abstract 5264: Recombinant Human Angiotensin Converting Enzyme 2 Normalizes Blood Pressure and Reduces the Progression of Diabetic Nephropathy
Authors: Gavin Y Oudit, George C Liu, Jiu-Chang Zhong, Manfred Schuster, Josef M Penninger, Andrew M Herzenberg, Zamaneh Kassiri, James W Scholey
Journal: Circulation (2009)

Background: Diabetes nephropathy is one of the most common causes of end-stage renal failure. Inhibition of ACE2 function exacerbates diabetic kidney injury while renal ACE2 is downregulated in diabetic nephropathy. We hypothesize that recombinant human ACE2 (rhACE2) will slow the progression of diabetic kidney injury. Methods and Results: Male 12-week old diabetic Akita mice ( Ins2 WT/C96Y ) and controls ( Ins2 WT/WT ) were injected daily with rhACE2 (2 mg/kg, i.p.) or placebo for four consecutive weeks. In Akita Ins2 WT/C96Y mice injected with hrACE2, plasma ACE2 activity showed a marked increase resulting in significant reduction in urinary albumin excretion (118±21 vs 224±16 μ g/24 hrs; n=6~8; p&lt;0.05). Treatment with rhACE2 decreased renal cortical angiotensin (Ang) II (12.1±1.9 vs 22.4±3.2 pg/mg; p&lt;0.05) and increased Ang (1–7) (14.2±2.1 vs 8.8±1.9 pg/mg; p&lt;0.05) levels, respectively, independent of changes in the expression of Ace and Ace2 while NADPH oxidase activity in renal cortical tissue from Akita mice was reduced by treatment with rhACE2 (364±45 vs 1720±277 RLU/sec/mg protein; n=6, p&lt;0.05). These effects resulted in normalization of the increased extracellular matrix gene expression ( α -smooth muscle actin, collagen III and fibronectin), reduction in glomerular volume and basement membrane thickness in the diabetic Akita mice. Activation of protein kinase C (PKC)á and PKCâ was reduced by 60 –70% in Akita diabetic mice treated with rhACE2. Ang II and high glucose-induced reactive oxygen species generation was evaluated using lucigenin-based NADPH oxidase activity and DHE fluorescence in cultured rat mesangial cells was suppressed by 25 and 250 ng/ml of rhACE2 in a dose-dependent manner. The mild hypertension in Akita Ins2 WT/C96Y mice was normalized by treatment with rhACE2 (122.3±2.1 vs 108.4±1.9 mmHg; n=6, p&lt;0.05) while the beneficial effects seen with rhACE2 occurred in the absence of hyperkalemia or acute renal failure and without a differential impact on hyperglycemia in the Akita diabetic model. Conclusions: We conclude that biologic antagonism of the RAS using rhACE2 can slow the progression of diabetic kidney injury and ACE2 may prove to be a useful adjunctive therapy for diabetic kidney disease.
ATM Mutant Chronic Lymphocytic Leukaemia Cells are Chemosensitized by Inhibition of DNA-Dependent Protein Kinase
Authors: Elaine Willmore, Ana Skowronska, Evan A Mulligan, G. Ahmed, Sarah Elliott, Geoffrey P Summerfield, Karen Hamlen, Chris Lowe, Barbara W Durkacz, Tanja Stankovic
Journal: Blood (2010)