tbuckley/cabot-search huggingface dataset:
Death Following Fiberoptic Gastroscopy Caused by Pheochromocytoma
Authors: J Crowe, K Bottomley, C F McCarthy
Journal: Endoscopy (1977)

A 45-year-old woman was admitted to hospital for investigation of weight loss, sciatica and excess sweating. On examination, whe was found to have a tachycardia and the stigmata of von Recklinghausen's disease. Her investigations included a barium meal and gastroscopy. Following the gastroscopy, she developed ventricular tachycardia and died. An autopsy revealed a pheochromocytoma of the left adrenal gland.
MEDICAL CARE OF AVIATION PERSONNEL
Authors: David N. W. Grant
Journal: Annals of Internal Medicine (1943)

Article1 June 1943MEDICAL CARE OF AVIATION PERSONNELDAVID N. W. GRANTDAVID N. W. GRANTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-6-926 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe opportunity to speak before the regional meeting of the American College of Physicians, an organization so well known for its pioneer work in elevating and improving the standards of medical practice, is indeed a pleasure. Your college has offered recognition to physicians attaining a certain degree of proficiency, and at the same time, which is perhaps more important, has provided through its scientific sessions and its publications, invaluable postgraduate instruction.Due to the efforts of such organizations, American medicine has indeed made phenomenal advances. Since 1900, the total death rate per 100,000 has been reduced nearly 50 per cent... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Air Surgeon U. S. Army Air Forces Washington, D. C.*Delivered before a Regional Meeting of the American College of Physicians at Chicago, November 21, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1943Volume 18, Issue 6Page: 926-928KeywordsDeath rates ePublished: 1 December 2008 Issue Published: 1 June 1943 PDF downloadLoading ...
THE INTERNIST'S NUMBER ONE PROBLEM-CHRONIC DISEASE IN AN AGING POPULATION
Authors: H A RUSK
Journal: Annals of Internal Medicine (1950)

Article1 December 1950THE INTERNIST'S NUMBER ONE PROBLEM-CHRONIC DISEASE IN AN AGING POPULATIONHOWARD A. RUSK, M.D., F.A.C.P.HOWARD A. RUSK, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-6-1341 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the minds of most internists, physical medicine and rehabilitation is a medical specialty which is primarily applicable to the specialties of orthopedics, surgery and neurology, but which lacks a close relationship to internal medicine. Until the last few years this concept was somewhat justified, for physical medicine was largely concerned with the passive application of light, heat, water and massage, and, although widely used in the treatment of peripheral vascular diseases, arthritis and other disorders of particular interest to internists, the greater emphasis was placed upon orthopedic and neurologic conditions.During the past few years, however, there has developed... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Presented at the Thirty-first Annual Session of the American College of Physicians, Boston, Massachusetts, April 21, 1950.From the Department of Physical Medicine and Rehabilitation, New York University-Bellevue Medical Center. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySpatial Differences in China's Population Aging and Influencing Factors: The Perspectives of Spatial Dependence and Spatial HeterogeneityA REALISTIC APPROACH TO REHABILITATION IN GERIATRICS 1 December 1950Volume 33, Issue 6Page: 1341-1348KeywordsAgingArthritisNeurologyOrthopedic surgeryOrthopedicsPeripheral vascular diseaseRehabilitation medicineVascular medicine ePublished: 1 December 2008 Issue Published: 1 December 1950 Copyright & PermissionsCopyright, 1950, by The American College of PhysiciansPDF downloadLoading ...
General Considerations of the Rôle of Surgery in Pulmonary Tuberculosis
Authors: Gerald B. Webb
Journal: Annals of Internal Medicine (1930)

Article1 October 1930General Considerations of the Rôle of Surgery in Pulmonary TuberculosisGERALD B. WEBBGERALD B. WEBBSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-4-372 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTuberculosis in any part of the body is generally considered to be a medical disease. Surgical intervention then is a confession of failure on the part of the physician. At present tuberculosis of a single kidney is the only condition that physicians instantly submit to operation. Chisholm's complete cauterization operation for rectal fistula is doubtless a surgical success. So-called surgical tuberculosis is, strictly speaking, not surgical. Tuberculous joints are treated by rest, by splinting and by sun therapy. For the most part tuberculous lymph nodes, tuberculous testicles, and tuberculous intestines, are not operated; a tuberculous larynx is treated by a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Colorado Springs, Colorado*Presented before the American College of Physicians February 14, 1930, Minneapolis, as Part of a Symposium on "The Surgery of Pulmonary Tuberculosis." PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1930Volume 4, Issue 4Page: 372-375KeywordsFistulasKidneysLarynxLymph nodesSurgery ePublished: 1 December 2008 Issue Published: 1 October 1930 PDF downloadLoading ...
Single Cell Mass Cytometry for Phenotypic Analysis of Diffuse Large B-Cell Lymphoma
Authors: Manabu Kusakabe, Guillermo Simkin, Justin Meskas, Chaoran Zhang, Daisuke Ennishi, Merrill Boyle, David W. Scott, Christian Steidl, Randy D. Gascoyne, Ryan R. Brinkman, Andrew P Weng
Journal: Blood (2014)
Abstract 10127: Persistent Insulin Resistance After Optimized Therapy for Atherosclerotic Risk Factors is a Predictor of an Adverse Outcome in Non-Diabetic Patients with Coronary Artery Disease
Authors: Yoshinobu Kitta, Takamitsu Nakamura, Wataru Sugamata, Manabu Uematsu, Juntaro Deyama, Keita Sano, Yukio Saito, Ken-ichi Kawabata, Jun-ei Obata, Kiyotaka Kugiyama
Journal: Circulation (2011)

Insulin resistance (IR) is a strong predictor of cardiovascular (CV) events even before the onset of diabetes. IR is reversible after a reduction in atherosclerotic risk factor burden by medication...
Correction: PO_2 on O_2 Therapy
Authors: MICHAEL LIPPMAN
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 July 1973Correction: PO2 on O2 TherapyMICHAEL LIPPMAN, M.D.MICHAEL LIPPMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-1-142_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: There appears to be an error of omission in the article by Levy and associates (78:213-219, 1973). The reader is led to believe that the oxygen fraction of inspired gas of the five patients with severe metabolic acidosis is that of room air, or 21% oxygen. Yet Patient J.F. had a PO2of 144 mm Hg on admission. This would be extremely unlikely without supplemental oxygen, as 150 mm Hg ([760-47] X 0.21) would be the maximal attainable PO2breathing room air. A healthy, young, normal individual would have great difficulty reaching this PO2, not to mention... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1973Volume 79, Issue 1Page: 142-142KeywordsAcidosisBreathingOxygenPartial pressure of oxygen Issue Published: 1 July 1973 PDF downloadLoading ...
Abstract 13291: Twenty-Two Year Trends in Incidence of Myocardial Infarction, CHD Mortality, and Case-Fatality in Four US Communities, 1987 to 2008
Authors: Wayne D Rosamond, Lloyd Chambless, Gerardo Heiss, Thomas Mosley, Josef Coresh, Eric Whitsel, Lynne Wagenknecht, Hanyu Ni, Aaron Folsom
Journal: Circulation (2011)

Knowledge of trends in the incidence of and survival after myocardial infarction (MI) in a community setting is important to understanding national trends in coronary heart disease (CHD) mortality ...
Abstract 11660: A Mixture of Fibronectin, Fibrinogen and Tropoelastin is Able to Inhibit Smooth Muscle Cell Migration and to Promote Reendothelialization in vitro
Authors: Claudia Tersteeg, Mark Roest, Elske M Mak-Nienhuis, Erik Ligtenberg, Imo Hoefer, Philip G de Groot, Gerard Pasterkamp
Journal: Circulation (2011)
P0318 : Ultra-deep sequencing of multiplex-PCR enriched hotspot and disease-related targets in hepatocellular carcinoma
Authors: W. Amer, U. Koitzsch, C. Vollbrecht, A. Quaas, R. Samara, A. Arens, R. Büttner, U. Drebber, J. Huang, M. Odenthal
Journal: Journal of Hepatology (2015)
Difficult access in the anaesthetic room leads to a difficult diagnosis:
Authors: Sarah Crabtree, Danielle Lowry, Alok Tiwari, Neil Gittoes
Journal: BMJ (2015)

A 50 year old man was admitted for laser ablation of the left long saphenous vein to treat his symptomatic varicose veins. In the anaesthetic room he was noted to have unusually tough skin and rather large hands during cannulation. This was confirmed when the operating surgeon attempted to cannulate the long saphenous vein to perform the endovenous laser ablation—the thickness of his skin made this difficult. He also had bigeminy on heart monitoring and a prominent jaw.

In clinic he said that he had always had large hands and put this down to being “muscly,” having worked in a garage all his life. He had surgery for carpal tunnel decompression in 2005, and he had longstanding muscle aches. His visual fields were normal, his shoe size was 9, and he snored excessively at night.



### 1. What is the likely diagnosis and what are the initial investigations needed to diagnose it?

#### Answer

The most likely diagnosis is acromegaly. Initial tests include measurement of insulin like growth factor 1 (IGF-1) and growth hormone, as well as growth hormone response to glucose tolerance test. If indicated, these should be followed by magnetic resonance imaging of the pituitary and visual field tests.

#### Discussion

Acromegaly can cause thickening of the skin, mainly secondary to dermal thickening.1 If acromegaly is suspected then both IGF-1 and growth hormone should be measured. IGF-1 is measured because its secretion is regulated by growth hormone. The results should be interpreted according to the normal ranges for the patients’ age and sex. Raised IGF-1 supports a diagnosis of acromegaly, although the result can be affected by poorly controlled diabetes and other systemic illnesses that lead to false negative results.2 Growth …
The relative impact of smoking and oral contraceptive use on women in the United States
Authors: G. M. Goldbaum
Journal: JAMA (1987)

Women who smoke and use oral contraceptives (OCs) are at increased risk for cardiovascular and cerebrovascular disease. To study the prevalence of smoking and OC use and of other behaviors affecting health, 28 states and the District of Columbia conducted telephone surveys during 1981 through 1983. More than 22 000 US adults were interviewed, of whom 5779 women aged 18 to 44 years were studied. Data were weighted to represent the US population. Overall, 7.4% of US women aged 18 to 44 years reported smoking and using OCs; 1.1% reported smoking 25 or more cigarettes per day while using OCs. Although women aged 18 to 24 years were most likely to smoke and use OCs, combined smoking and OC use contributed substantially to the number of excess cases of myocardial infarctions occurring among US women aged 35 to 44 years. However, regardless of OC use, smoking accounted for most of the excess cases. Therefore, health care providers need to intensify their efforts to reduce smoking among their patients. (<i>JAMA</i>1987;258:1339-1342)
Comparison of O-6-MethyIguanine DNA Methyltransferase (MGMT) mRNA Levels in Mer<sup>+</sup> and Mer<sup>−</sup> Human Tumor Cell Lines Containing the MGMT Gene by the Polymerase Chain Reaction Technique
Authors: Russell O. Pieper, Bernard W. Futscher, Qing Dong, Thomas M. Ellis, Leonard C. Erickson
Journal: Cancer Communications (1990)

O-6-Alkylguanine is a mutagenic and carcinogenic DNA lesion induced by a variety of alkylating agents, including the chloroethylnitrosoureas. The lesion is repaired by the alkyl-accepting suicide enzyme O-6-methylguanine DNA methyltransferase (MGMT). Approximately 25% of cell lines derived from human tumors are phenotypically deficient in this enzyme and are described as Mer-. Recent cloning of the human MGMT cDNA (Tano, K.; Shiota, S.; Collier, J.; Foote, R.S.; Mitra, S. Proc. Natl. Acad. Sci. USA 87:686-690; 1990) has allowed for a more detailed analysis of the basis of the Mer- phenotype in human Mer- tumor cell lines. Using the polymerase chain reaction (PCR) technique, an MGMT cDNA probe based on the published sequence was generated. The probe and the PCR technique were then used to analyze the presence and expression of the MGMT gene in two Mer+ and four Mer- lines, including one SV40-transformed Mer- line and three Mer- human tumor cell lines. The data demonstrate that while all six cell lines contained a relatively nonamplified, nonrearranged MGMT gene, Mer- lines contained levels of MGMT mRNA detectable only by PCR analysis. Of the three Mer- tumor cell lines examined, two (COLO 320 HSR, A1235) contained MGMT mRNA levels that were four to five orders of magnitude lower than that of the prototype Mer+ tumor line (HT-29), while one (BE) contained no consistently detectable MGMT mRNA. These results suggest that in the human Mer- tumor lines tested, the Mer- phenotype was mediated by a severe reduction in MGMT mRNA levels, despite the presence of the MGMT gene.
Abstract 16119: Novel Genotype Guided Personalized Warfarin Service Improves Outcomes in an Ethnically Diverse Population
Authors: Edith Nutescu, Julio Duarte, Wendy Cheng, Shishir Sarangpur, Deval Gor, Katarzyna Drozda, William Galanter, Thomas Stamos, David Peace, John Garofalo, Jerry Khrishnan, Larisa Cavallari
Journal: Circulation (2014)

Objective:  Personalized warfarin dosing was implemented at UI-Health, with dosing recommendations provided by a pharmacogenetics (PGx) consult service. Our aim was to compare anticoagulation-related outcomes between patients followed by the PGx service and historical controls.   Methods:  Multivariate linear, logistic, and Cox regression models were used to examine the association between exposure to the PGx service and outcomes.   Results:  A total of 389 patients on the PGx service (mean age 56±16 years; 53% African American; 56% female) and 308 controls (mean age 53±16 years; 71% African American, 64% female) were included. The median (IQR) time to therapeutic INR was 4 (2-6) days in the PGx group and 11 (7-15) days in controls (p   Conclusion:  Clinical implementation of personalized warfarin dosing improved time to therapeutic INR and stable dose, increased the likelihood of having a therapeutic INR on discharge, reduced the likelihood of INRs at extremes and led to shorter use of LMWH versus historical controls.
Abstract 14691: Inhibition of Activin A is the Novel Therapeutic Target for Heart Failure
Authors: Noritoshi Fukushima, Katsuhisa Matsuura, Hiroshi Akazawa, Atsushi Honda, Toshio Nagai, Toshinao Takahashi, Akiko Seki, Kagari Murasaki, Tatsuya Shimizu, Teruo Okano, Issei Komuro, Nobuhisa Hagiwara
Journal: Circulation (2011)

Paracrine effects are thought to be the major mechanisms of cardiac cell therapy. We previously reported that bone marrow mononuclear cells (BMMNC) infusion improved cardiac function of non-ischemi...
Abstract 13586: Analysis of a Different Device-Based Intrathoracic Impedance Vector for Detection of Heart Failure Events: Results of the DEFEAT-PE Study
Authors: E. Kevin Heist, John M Herre, Philip F Binkley, Adrian B Van Bakel, James G Porterfield, Linda M Porterfield, Behzad B Pavri
Journal: Circulation (2011)

Background: Detection of changes in intrathoracic impedance measured between the right ventricular (RV) coil and the device can (RVcoil→Can) of implantable cardioverter defibrillators (ICDs) is approved for clinical use in detection of pulmonary congestion (PC) events. However, an RVring→Can vector has not been evaluated for this purpose. Objective: The DEFEAT-PE study is a prospective study that evaluated the performance of an RVring→Can vector to detect changes in intrathoracic impedance vectors associated with CHF events. Methods: An initial derivation set of 75 patients was used to analyze optimal impedance vectors for detection of PC events, and a vector of RVring-Can was selected for prospective analysis. 162 patients were then enrolled in DEFEAT-PE (81 with ICDs and 81 with cardiac resynchronization therapy ICDs, 64+13 yrs, 72% male, EF 25+10%, 54% ischemic, all with at least 1 prior PC event). PC events during the study were adjudicated by a blinded clinical events committee. Device-detected imped...
An acidic polysaccharide Ginsan inhibits spontaneously occurring apoptosis of human granulocytes
Authors: Makoto Akashi, Keiko Watanabe, Sang-Hee Park
Journal: Cancer Research (2004)

Proc Amer Assoc Cancer Res, Volume 45, 2004

2957 

The acute inflammatory response is accompanied by an increased number of granulocytes. However, granulocytes are short-lived cells in the circulation; they spontaneously undergo apoptosis. The number of these cells is regulated by the balance of their production and elimination through apoptosis. Since extremely rapid changes in the number of granulocyes have to be made in response to insults, other mechanisms than an enhanced production and maturation of these cells in the bone marrow are required. The root of Panax ginseng C. A. Meyer is one of the most popular medicinal plants in oriental countries. Ginsan is a purified acidic polysaccharide isolated from the roots, with molecular weight of 150,000. We studied the effect of Ginsan on the spontaneous apoptosis of human granulocytes in vitro by morphological analysis of cell nuclei, gel electrophoresis of DNA fragments, and Annexin V staining. Almost 60% of granulocytes underwent spontaneous apoptosis by 20 h. Ginsan inhibited the spontaneous apoptosis of granulocyes in a dose-dependent manner. At a concentration of 50 μg/ml, Ginsan reduced the rate of apoptotic cells to as low as 10%. Previous studies have shown that mitogen activated protein kinases (MAPKs) are involved in the spontaneous apoptosis of granulocytes. To determine whether the p38 MAPKor the extracellular signal-related protein kinase (ERK) pathway is involved in the spontaneous apoptosis of these cells, we used a specific inhibitor of p38MAPK, SB203580 or MAPK kinase (MEK) inhibitor, PD98059. Treatment of granulocytes with either of these inhibitors significantly inhibited the spontaneous apoptosis. On the other hand, Ginsan activated ERK and inhibition of the ERK pathway by PD98059 blocked the anti-apoptotic effect of Ginsan, whereas inhibition of p38MAPK did not affect. Our findings suggest that both p38MAPK and ERK pathways are involved in the spontaneous apoptosis in granulocyes and that Ginsan inhibits their spontaneous apoptosis through a pathway requiring activation of ERK. Recent studies have shown that Ginsan is an immuno-modulator and also a radio-protector. Regulation of granulocyte survival may be one of the important mechanisms responsible for activities of Ginsan.
Downregulation of aurora-A overrides estrogen -mediated growth and chemoresistance in breast cancer cells
Authors: Hong Lee Heng, Yansong Zhu, Gopalan Ganesan
Journal: Clinical Cancer Research (2007)

AACR Centennial Conference: Translational Cancer Medicine-- Nov 4-8, 2007; Singapore

B10 

Estrogen is known to play a causative role in the development of sporadic breast cancers and chemoresistance. However, studies on the mechanism and proteins involved in mediating the oncogenic effects of estrogen are very limited. Recently, Aurora-A, a centrosomal protein kinase, which induces centrosome amplification and genomic instability, was shown to be upregulated during long-term treatment of rats with estrogen and was implicated in estrogen-induced oncogenesis. Herein, we present results of the studies carried out in short term in vitro cultures to understand the regulation of Aurora-A by estrogen and the effect of downregulation of Aurora-A on estrogen-induced breast tumorigenesis and chemoresistance. Treatment of breast cancer cells with 10 nM 17-β estradiol (E2) resulted in the upregulation of Aurora-A levels in an ER-dependent manner. However, the upregulation by E2 was not restricted to Aurora-A alone. Following release from the tamoxifen-induced arrest, the appearance of Aurora-A in the presence of estradiol in MCF7 cells coincided with the appearance of other mitotic markers suggesting that the spike in Aurora-A levels is an indirect consequence of estrogen-mediated cell proliferation. Thus, at least in short term in vitro studies, Aurora-A is not a specific, direct target of estrogen. However, downregulation of Aurora-A by short RNA interference, led to a significant decrease in estrogen-induced, anchorage-dependent and independent growth of MCF7 cells. Moreover, knockdown of Aurora-A could overcome estrogen-induced decrease in docetaxel (Doc) sensitivity of MCF7 cells. Cumulatively, we propose that the up-regulation of Aurora-A by estrogen in short-term in vitro cultures is an indirect consequence of estrogen-induced cell proliferation. Nevertheless, Aurora-A inhibitors could be exploited to override the effects of estrogen on breast tumorigenesis and chemoresistance.
Positron Emission Tomography (PET) Applied to Stereotactic Interstitial Brain Brachytherapy for Malignant Glioma Patients
Authors: H. W. Chin, JM. Bertoni, A. H. Fruin
Journal: Neuro-Oncology (1991)

Until now, CT and MRI scans have been the diagnostic studies of choice for the localization of tumors in the central nervous system. However, these radiological modalities have limited value for the accurate assessment of active tumor lesions, since they provide anatomical information only and are not able to identify active tumors. Recently, the new biological imaging modality of Positron Emission Tomography (PET) became available. The functional nature of PET allows diagnosis of tumor activity, which can not be demonstrated by anatomic imaging studies. We have treated six patients with high-grade malignant glioma using stereotactic interstitial brain brachytherapy since PET imaging studies became available in this facility. Our results indicate that PET is useful for follow up of brain tumor after brain brachytherapy.