A CONSIDERATION OF THE FACTOR OF CHANGE IN THE ANIMAL ORGANISM
Authors: Wm. Deb. Macnider
Journal: Annals of Internal Medicine (1942)

Article1 December 1942A CONSIDERATION OF THE FACTOR OF CHANGE IN THE ANIMAL ORGANISMWM. DEB. MACNIDER, F.A.C.P.WM. DEB. MACNIDER, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-6-989 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFixity of any order, even fixity of purpose, tends to bind and render inelastic the structure or the individual in which such a property develops. It is a quality which is inimicable to adaptation, and tissues or organisms without this quality of elasticity, of variability, have difficulty in meeting the exigencies of life which is made up of periods of adequate adaptation, never perfect, and periods of inadequate adaptation which may be of such a specialized nature as to produce the symptoms and later show the signs of disease.Since 1907 the investigations in this laboratory have not been so...Bibliography1. MELTZER SJ: The factors of safety in animal structure and animal economy, The Harvey Lectures, 1906-1907, 139; 1908, J. B. Lippincott Company, Philadelphia. Google Scholar2. CANNON WB: The wisdom of the body, 1932, W. W. Norton & Company, Inc., New York. CrossrefGoogle Scholar3. MACNIDER WD: The acute degenerative changes and the changes of recuperation occurring in the liver from the use of ethyl alcohol. A functional and pathological study, Jr. Pharmacol. and Exper. Therap., 1934, xlix, 100. Google Scholar4. MACNIDER WD: The influence of liver degeneration and recuperation on the acid-base equilibrium of the blood, Jr. Pharmacol. and Exper. Therap., 1934, l, 108. Google Scholar5. MACNIDER WD: A study of the acquired resistance of fixed tissue cells morphologically altered through processes of repair. I. The liver injury induced by uranium nitrate. A consideration of the type of epithelial repair which imparts to the liver resistance against subsequent uranium intoxications, Jr. Pharmacol. and Exper. Therap., 1936, lvi, 359. Google Scholar6. MACNIDER WD: II. The resistance of liver epithelium altered morphologically as the result of an injury from uranium, followed by repair, to the hepatoxic action of chloroform, Jr. Pharmacol. and Exper. Therap., 1936, lvi, 373. Google Scholar7. MACNIDER WD: III. The resistance to chloroform of a naturally acquired atypical type of liver epithelium occurring in senile animals, Jr. Pharmacol. and Exper. Therap., 1936, lvi, 383. Google Scholar8. WHIPPLESPERRY GHJA: Chloroform poisoning. Liver necrosis and repair, Bull. Johns Hopkins Hosp., 1909, xx, 278. Google Scholar9. MACNIDER WD: On the difference in the response of animals of different ages to a constant quantity of uranium nitrate, Proc. Soc. Exper. Biol. and Med., 1914, xi, 159. CrossrefGoogle Scholar10. MACNIDER WD: A consideration of the relative toxicity of uranium nitrate for animals of different ages, Jr. Exper. Med., 1917, xxvi, 1. CrossrefGoogle Scholar11. MACNIDER WD: IV. Concerning the persistence of an acquired type of atypical liver cell with observations on the resistance of such cells to the toxic action of chloroform, Jr. Pharmacol. and Exper. Therap., 1937, lix, 393. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chapel Hill, North Carolina*Convocation Address, The American College of Physicians, St. Paul, Minnesota, April 22, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAge, Change and the Adapted Life 1 December 1942Volume 17, Issue 6Page: 989-994KeywordsResearch laboratories Issue Published: 1 December 1942 PDF downloadLoading ...