tbuckley/cabot-search huggingface dataset:
Awareness of strengths and weaknesses of Cardiovascular Magnetic Resonance Imaging (CMR) – Results from a questionnaire survey
Authors: Victoria Zieschang, Rebecca Elisabeth Beyer, Maximilian Leo Müller, Frederike Trautmann, Titus Kühne, Eike Nagel, Andreas Rolf, Andreas Schuster, Grigorios Korosoglou, Henning Steen, Ali Yilmaz, Steffen E Petersen, Bjoern Andrew Remppis, Gisela Thiede, Anna Clara Nolden, Sebastian Kelle
Journal:  (2024)

Extensive research has established cardiovascular magnetic resonance (CMR) as a powerful tool for diagnosing and monitoring various cardiovascular diseases (CVDs). However, CMR has yet to reach its full potential in routine clinical care, which is mainly due to reimbursement issues. Among other factors, overcoming this gap requires adequate awareness among healthcare professionals and potential patients, the extent of which is currently unknown. Therefore, we conducted a survey to assess awareness and identify knowledge gaps regarding the clinical role and socio-economic factors associated with CMR.
Early Access to First-Seizure Clinics, Subsequent Outcomes, and Factors Associated With Attendance
Authors: Yingtong Li, Tianrui Ren, Michael Burgess, Zhibin Chen, Patrick W. Carney, Terence J. O’Brien, Patrick Kwan, Emma Foster
Journal: JAMA Neurology (2024)

First-seizure clinics (FSCs) aim to deliver prompt specialist care to patients with new-onset undifferentiated seizure events.
Agile scores in MASLD and ALD: External validation and their utility in clinical algorithms
Authors: Margarita Papatheodoridi, Victor De Ledinghen, Monica Lupsor-Platon, Fabrizio Bronte, Jerome Boursier, Omar Elshaarawy, Fabio Marra, Maja Thiele, Georgios Markakis, Audrey Payance, Edgar Brodkin, Laurent Castera, George Papatheodoridis, Aleksander Krag, Umberto Arena, Sebastian Mueller, Paul Cales, Vincenza Calvaruso, Adele Delamarre, Massimo Pinzani, Emmanuel A. Tsochatzis
Journal: Journal of Hepatology (2024)
The endocrine FGFs axis: A systemic anti-fibrotic response that could prevent pulmonary fibrogenesis?
Authors: Mada Ghanem, Gabrielle Archer, Bruno Crestani, Arnaud A. Mailleux
Journal: Pharmacology & Therapeutics (2024)

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease for which therapeutic options are limited, with an unmet need to identify new therapeutic targets. IPF is thought to be the consequence of repeated microlesions of the alveolar epithelium, leading to aberrant epithelial-mesenchymal communication and the accumulation of extracellular matrix proteins. The reactivation of developmental pathways, such as Fibroblast Growth Factors (FGFs), is a well-described mechanism during lung fibrogenesis. Secreted FGFs with local paracrine effects can either exert an anti-fibrotic or a pro-fibrotic action during this pathological process through their FGF receptors (FGFRs) and heparan sulfate residues as co-receptors. Among FGFs, endocrine FGFs (FGF29, FGF21, and FGF23) play a central role in the control of metabolism and tissue homeostasis. They are characterized by a low affinity for heparan sulfate, present in the cell vicinity, allowing them to have endocrine activity. Nevertheless, their interaction with FGFRs requires the presence of mandatory co-receptors, alpha and beta Klotho proteins (KLA and KLB). Endocrine FGFs are of growing interest for their anti-fibrotic action during liver, kidney, or myocardial fibrosis. Innovative therapies based on FGF19 or FGF21 analogs are currently being studied in humans during liver fibrosis. Recent data report a similar anti-fibrotic action of endocrine FGFs in the lung, suggesting a systemic regulation of the pulmonary fibrotic process. In this review, we summarize the current knowledge on the protective effect of endocrine FGFs during the fibrotic processes, with a focus on pulmonary fibrosis.
P Score: A Reference Image-Based Clinical Grading Scale for Vascular Change in Retinopathy of Prematurity
Authors: Gil Binenbaum, Andreas Stahl, Aaron S. Coyner, Jocelyn He, Gui-shuang Ying, Susan Ostmo, R. V. Paul Chan, Cynthia Toth, Anand Vinekar, J. Peter Campbell, Michael F. Chiang, Graham E. Quinn, Alistair R. Fielder, Susan R. Ostmo, R. V. Paul Chan, Audina Berrocal, Gil Binenbaum, Michael Blair, J. Peter Campbell, Antonio Capone, Yi Chen, Shuan Dai, Anna Ells, Brian W. Fleck, William V. Good, M. Elizabeth Hartnett, Gerd Holmstrom, Shunji Kusaka, Andrés Kychenthal, Domenico Lepore, Birgit Lorenz, Maria Ana Martinez-Castellanos, Şengu¨l O¨zdek, Dupe Ademola-Popoola, James D. Reynolds, Parag K. Shah, Michael Shapiro, Andreas Stahl, Cynthia Toth, Anand Vinekar, Linda Visser, David K. Wallace, Wei-Chi Wu, Peiquan Zhao, Andrea Zin, Francine Baran, Gerard Barry, Audina Berrocal, Amit Bhatt, Gil Binenbaum, Michael Blair, J. Peter Campbell, Shuan Dai, Bradley Davitt, Alejandra de Alba Campomanes, Amgad Eldib, Alistair R. Fielder, Brian W. Fleck, Brooke E. Geddie, Kathryn Haider, M. Elizabeth Hartnett, Gerd Holmstrom, Anne Jensen, Monica Khitri, Shunji Kusaka, Maria Ana Martinez-Castellanos, Susan R. Ostmo, Dupe Ademola-Popoola, Matthew Pihlblad, Graham E. Quinn, Michael Repka, Shira Robbins, Sarah Rodriguez, Parag K. Shah, Andreas Stahl
Journal: Ophthalmology (2024)
Annular Conductive Hydrogel‐Mediated Wireless Electrical Stimulation for Augmenting Neurogenesis
Authors: Jing Hong, Zhanchi Zhu, Zhaojun Wang, Jiawei Li, Zhongqing Liu, Rui Tan, Ying Hao, Guosheng Cheng
Journal: Advanced Healthcare Materials (2024)

Electrical stimulation (ES) has a remarkable capacity to regulate neuronal differentiation and neurogenesis in the treatment of various neurological diseases. However, wired devices connected to the stimulating electrode and the mechanical mismatch between conventional rigid electrodes and soft tissues restrict their motion and cause possible infections, thereby limiting their clinical utility. An approach integrating the advantages of wireless techniques and soft hydrogels provides new insights into ES-induced nerve regeneration. Herein, a flexible and implantable wireless ES-responsive electrode based on an annular gelatin methacrylate-polyaniline (Gel/Pani) hydrogel is fabricated and used as a secondary coil to achieve wireless ES via electromagnetic induction in the presence of a primary coil. The Gel/Pani hydrogels exhibit favorable biocompatibility, biodegradability, conductivity, and compression resistance. The annular electrode of the Gel/Pani conductive hydrogel (AECH) supports neural stem cell growth, while the applied wireless ES facilitates neuronal differentiation and the formation of functional neural networks in vitro. Furthermore, AECH is implanted in vivo in rats with ischemic stroke and the results reveal that AECH-mediated wireless ES significantly ameliorates brain impairment and neurological function by activating endogenous neurogenesis. This novel flexible hydrogel system addresses wireless stimulation and implantable technical challenges, holding great potential for the treatment of neurodegenerative diseases.
Identification of restrictive molecules involved in oncolytic virotherapy using genome-wide CRISPR screening
Authors: Yiye Zhong, Huangying Le, Xue Zhang, Yao Dai, Fang Guo, Xiaojuan Ran, Guohong Hu, Qi Xie, Dawei Wang, Yujia Cai
Journal: Journal of Hematology & Oncology (2024)

Abstract Oncolytic viruses (OVs) offer a novel approach to treat solid tumors; however, their efficacy is frequently suboptimal due to various limiting factors. To address this challenge, we engineered an OV containing targets for neuron-specific microRNA-124 and Granulocyte-macrophage colony-stimulating factor ( GM-CSF ), significantly enhancing its neuronal safety while minimally compromising its replication capacity. Moreover, we identified PARP1 as an HSV-1 replication restriction factor using genome-wide CRISPR screening. In models of glioblastoma (GBM) and triple-negative breast cancer (TNBC), we showed that the combination of OV and a PARP inhibitor (PARPi) exhibited superior efficacy compared to either monotherapy. Additionally, single-cell RNA sequencing (scRNA-seq) revealed that this combination therapy sensitized TNBC to immune checkpoint blockade, and the incorporation of an immune checkpoint inhibitor (ICI) further increased the survival rate of tumor-bearing mice. The combination of PARPi and ICI synergistically enhanced the ability of OV to establish durable tumor-specific immune responses. Our study effectively overcomes the inherent limitations of OV therapy, providing valuable insights for the clinical treatment of TNBC, GBM, and other malignancies.
Biflanged metal stents versus plastic stents for endoscopic ultrasound-guided drainage of walled-off necrosis: a randomized controlled trial
Authors: Krithi Krishna Koduri, Nitin Jagtap, Sundeep Lakhtakia, Basha Jahangeer, Shujaath Asif, Rupjyoti Talukdar, Guru Trikudanathan, Manu Tandan, Rakesh Kalapala, Zaheer Nabi, Rajesh Gupta, Mohan Ramchandani, Jagadish Singh, Sana Fatima Memon, G. Venkat Rao, D. Nageshwar Reddy
Journal: Endoscopy (2024)

Abstract Background Endoscopic ultrasound (EUS)-guided drainage of walled-off necrosis (WON) using either plastic or metal stents is the mainstay of WON management. Our single-center randomized controlled trial aimed to evaluate the efficacy of biflanged metal stents (BFMSs) and plastic stents for WON drainage. Methods Patients with symptomatic WON amenable to EUS-guided drainage were randomized to receive either BFMSs or plastic stents. The primary outcome was reintervention-free clinical success at 4 weeks. Secondary outcomes were: overall clinical success (complete resolution of symptoms and significant reduction in size of WON [&lt;50% of original size and &lt;5 cm in largest diameter at 4-week follow-up]); number of reinterventions; adverse events (AEs); hospital stay for first admission; and medium-term outcomes at 6 months (recurrence, disconnected pancreatic duct, chronic pancreatitis, and new-onset diabetes mellitus). Results 92 patients were randomized: 46 in each arm. The reintervention-free clinical success rate was significantly higher in the BFMS group on intention-to-treat analysis (67.4% vs. 43.5%; P = 0.02). Overall clinical success at 1 month was similar in both groups. There were significantly fewer reinterventions (median 0 [IQR 0–1] vs. 1 [0–2]; P = 0.03) and shorter hospital stays in the BFMS group (7.0 [SD 3.4] vs. 9.1 [5.5] days; P = 0.04). There were no differences in procedure-related AEs, mortality, or medium-term outcomes. Conclusions BFMSs provide better reintervention-free clinical success at 4 weeks, with shorter hospital stay and without increased risks of AEs, compared with plastic stents for EUS-guided drainage of WON. Medium-term outcomes are however similar for both stent types.
Burden of bacterial antimicrobial resistance in low-income and middle-income countries avertible by existing interventions: an evidence review and modelling analysis
Authors: Joseph A Lewnard, Esmita Charani, Alec Gleason, Li Yang Hsu, Wasif Ali Khan, Abhilasha Karkey, Clare I R Chandler, Tapfumanei Mashe, Ejaz Ahmed Khan, Andre N H Bulabula, Pilar Donado-Godoy, Ramanan Laxminarayan
Journal: The Lancet (2024)
Ensuring progress on sustainable access to effective antibiotics at the 2024 UN General Assembly: a target-based approach
Authors: Marc Mendelson, Joseph A Lewnard, Mike Sharland, Aislinn Cook, Koen B Pouwels, Yewande Alimi, Mirfin Mpundu, Evelyn Wesangula, Jeffrey Scott Weese, John-Arne Røttingen, Ramanan Laxminarayan
Journal: The Lancet (2024)
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Authors: Md Nannur Rahman, Nilakshi Barua, Martha C.F. Tin, Priyanga Dharmaratne, Sunny H. Wong, Margaret Ip
Journal: Gut Microbes (2024)

Repeated exposure to antibiotics and changes in the diet and environment shift the gut microbial diversity and composition, making the host susceptible to pathogenic infection. The emergence and ongoing spread of AMR pathogens is a challenging public health issue. Recent evidence showed that probiotics and prebiotics may play a role in decolonizing drug-resistant pathogens by enhancing the colonization resistance in the gut. This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut. We further studied the effects of prebiotics in human and animal studies. PubMed, Embase, Web of Science, Scopus, and CINAHL were used to collect articles. The random-effects model meta-analysis was used to pool the data. GRADE Pro and Cochrane collaboration tools were used to assess the bias and quality of evidence. Out of 1395 citations, 29 RCTs were eligible, involving 2871 subjects who underwent either probiotics or placebo treatment to decolonize AMR pathogens. The persistence of pathogenic bacteria after treatment was 22%(probiotics) and 30.8%(placebo). The pooled odds ratio was 0.59(95% CI:0.43-0.81), favoring probiotics with moderate certainty (
Essential principles for blood centrifugation
Authors: Marc Quirynen, Sayed Ahmad Manoetjer Siawasch, Jize Yu, Richard J. Miron
Journal: Periodontology 2000 (2024)

Abstract Currently, autologous platelet concentrates (APCs) are frequently used for soft‐ and hard‐tissue regeneration, not only within the oral cavity, but also extra‐orally including chronic wounds, burns, joints, dermatological conditions, among others. The benefits of APCs are largely influenced by the treatment strategy but also their preparation. This paper therefore discusses in detail: the physical properties of blood cells, the basic principles of blood centrifugation, the impact of the centrifugation protocol (rotations/revolutions per minute, g‐force, variation between centrifuges), the importance of timing during the preparation of APCs, the impact of the inner surface of the blood tubes, the use/nonuse of anticoagulants within APC tubes, the impact of the patient's hematocrit, age, and gender, as well as the important requirements for an optimal centrifugation protocol. All these variables indeed have a significant impact on the clinical outcome of APCs.
Donor lymphocyte infusion after allogeneic haematopoietic cell transplantation for haematological malignancies: basic considerations and best practice recommendations from the EBMT
Authors: Simona Pagliuca, Christoph Schmid, Nicole Santoro, Federico Simonetta, Giorgia Battipaglia, Thierry Guillaume, Raffaella Greco, Francesco Onida, Isabel Sánchez-Ortega, Ibrahim Yakoub-Agha, Jurgen Kuball, Mette D Hazenberg, Annalisa Ruggeri
Journal: The Lancet Haematology (2024)
Doxycycline prophylaxis and meningococcal group B vaccine to prevent bacterial sexually transmitted infections in France (ANRS 174 DOXYVAC): a multicentre, open-label, randomised trial with a 2 × 2 factorial design
Authors: Jean-Michel Molina, Beatrice Bercot, Lambert Assoumou, Emma Rubenstein, Michele Algarte-Genin, Gilles Pialoux, Christine Katlama, Laure Surgers, Cécile Bébéar, Nicolas Dupin, Moussa Ouattara, Laurence Slama, Juliette Pavie, Claudine Duvivier, Benedicte Loze, Lauriane Goldwirt, Severine Gibowski, Manon Ollivier, Jade Ghosn, Dominique Costagliola
Journal: The Lancet Infectious Diseases (2024)
Oral azacitidine compared with standard therapy in patients with relapsed or refractory follicular helper T-cell lymphoma (ORACLE): an open-label randomised, phase 3 study
Authors: Jehan Dupuis, Emmanuel Bachy, Franck Morschhauser, Guillaume Cartron, Noriko Fukuhara, Nicolas Daguindau, René-Olivier Casasnovas, Sylvia Snauwaert, Remy Gressin, Christopher P Fox, Francesco Annibale d’Amore, Philipp B Staber, Olivier Tournilhac, Krimo Bouabdallah, Catherine Thieblemont, Marc André, Shinya Rai, Daisuke Ennishi, Argyrios Gkasiamis, Mitsufumi Nishio, Luc-Matthieu Fornecker, Marie-Helene Delfau-Larue, Nouhoum Sako, Sebastien Mule, Laurence de Leval, Philippe Gaulard, Kunihiro Tsukasaki, François Lemonnier
Journal: The Lancet Haematology (2024)
Expanding antibiotic, vaccine, and diagnostics development and access to tackle antimicrobial resistance
Authors: Ramanan Laxminarayan, Isabella Impalli, Radha Rangarajan, Jennifer Cohn, Kavi Ramjeet, Betsy Wonderly Trainor, Steffanie Strathdee, Nithima Sumpradit, Daniel Berman, Heiman Wertheim, Kevin Outterson, Padmini Srikantiah, Ursula Theuretzbacher
Journal: The Lancet (2024)
Pembrolizumab and low-dose, single-fraction radiotherapy for patients with relapsed or refractory multiple myeloma: a prospective, single-centre, single-group, open-label, phase 2 pilot trial in the USA
Authors: Mohammad K Khan, Tahseen H Nasti, Joshua Y Qian, Troy J Kleber, Jeffrey M Switchenko, Jonathan L Kaufman, Ajay J Nooka, Madhav V Dhodapkar, Zachary S Buchwald, Daby Obiekwe, Sagar Lonial, Rafi Ahmed
Journal: The Lancet Haematology (2024)
Papillary Thyroid Cancer, Small Cell Lung Cancer, and Parathyroid Adenoma Synchronously Visualized on 99mTc-MIBI SPECT/CT in a Patient With Hyperparathyroidism
Authors: In Kook Chun, Seungkoo Lee
Journal: Clinical Nuclear Medicine (2024)

99m Tc-MIBI scintigraphy is a nuclear medicine imaging modality commonly used for the preoperative localization of parathyroid adenomas in patients with hyperparathyroidism. In addition, 99m Tc-MIBI can also be used for imaging various tumors due to its unique mechanism of intracellular accumulation. Here, we introduced a case of a single 99m Tc-MIBI SPECT/CT simultaneously visualized two different malignant tumors, such as papillary thyroid cancer and small cell lung cancer, along with a parathyroid adenoma in a patient with hyperparathyroidism. The clinical usefulness of 99m Tc-MIBI SPECT/CT was also explored by comparing it with 18 F-FDG PET/CT among the three tumors.
Triple Tumors (Neuroendocrine Tumor, Schwannoma, and Papillary Thyroid Carcinoma) With Brain Lesions in a Single Patient Demonstrating Avidity on 68Ga-DOTATATE PET/CT and Their Characterization With FDG-PET/CT and Brain MRI
Authors: Rahul V. Parghane, Sandip Basu
Journal: Clinical Nuclear Medicine (2024)

Neuroendocrine tumor (NET) typically spreads to the liver, lymph nodes, lungs, and skeleton. Brain metastasis in NET is uncommon. Therefore, each case of detected brain metastases in NET is crucial for the development of treatment guidelines for these types of tumors. We present a unique case of triple tumors (NET, papillary thyroid carcinoma, and schwannoma) in a single patient who presented with neurological symptoms and somatostatin receptor-avid T2 hyperintense multiple metastatic brain lesions from NET on 68 Ga-DOTATATE-PET/CT scan and brain MRI. Despite the rarity of brain metastases in NET, we conclude that the presence of neurological sign or symptoms and/or the detection of somatostatin receptor-avid brain lesions in patients with NET should raise suspicion of brain metastases.
Pleural Spindle Cell Sarcoma on 68Ga-DOTA-FAPI-04 PET/CT and 18F-FDG PET/CT
Authors: Yan Cui, Xin Zhou, Nan Li
Journal: Clinical Nuclear Medicine (2024)

Abstract A 67-year-old woman with pleural mass underwent 18 F-FDG PET/CT, suspected of malignant pleural tumor with intense 18 F-FDG uptake. Then she underwent 68 Ga-DOTA-FAPI-04 PET/CT for staging, which showed similar uptake in pleural lesions and opposite uptake pattern in mediastinal and hilar lymph nodes. Finally, she was diagnosed with spindle cell sarcoma (G2) by histopathology. After 1 cycle chemotherapy, the pleural lesions progressed, while mediastinal lymph nodes shrunk. Half a month later, the patient died due to rapid disease progression. This case indicates that 68 Ga-FAPI PET/CT might be a promising new tool in diagnosis and staging of pleural spindle cell sarcoma.
Adult Neuroblastoma of the Neck Is Better Imaged With 18F-FDG PET/CT Than With 18F-DOPA PET/CT
Authors: Yazan Z. Alabed
Journal: Clinical Nuclear Medicine (2024)

Abstract A 41-year-old woman presented with 2 months history of right submandibular swelling. Biopsy revealed neuroblastoma (NB). Patient was referred for staging PET/CT scan. We compared the findings of 18 F-DOPA PET/CT and 18 F-FDG PET/CT scans. Both imaging modalities were positive in the patient; however, tumor delineation was superior with 18 F-FDG PET/CT. Tumor uptake of FDG was significantly higher than tumor uptake of DOPA. Follow-up FDG PET/CT scan postsurgery showed local recurrent NB and their metastases avidly concentrate FDG. We present a very rare case of adult NB of the neck better imaged with FDG instead of DOPA PET/CT.
Estimated Fetal Radiation Dose From 18F-FDG PET/CT During the Second and Third Trimesters of Pregnancy
Authors: Laure Al Mansour, Perrine Tylski, Gautier Chene, Franck Plaisant, Marc Janier, Pierre Adrien Bolze, Benoit You, Didier Defez, Jérémie Tordo, Anthime Flaus
Journal: Clinical Nuclear Medicine (2024)

Data published in the literature concerning the doses received by fetuses exposed to a 18 F-FDG PET are reassuring but were obtained from small and heterogeneous cohorts, and very few data are available concerning the fetal dose received after exposure to both PET and CT. The present study aimed to estimate the fetal dose received following a PET/CT exposure using methods that include anthropomorphic phantoms of pregnant women applied on a large cohort.
Epidural analgesia during labour and severe maternal morbidity: population based study
Authors: Rachel J Kearns, Aizhan Kyzayeva, Lucy O E Halliday, Deborah A Lawlor, Martin Shaw, Scott M Nelson
Journal: BMJ (2024)

To determine the effect of labour epidural on severe maternal morbidity (SMM) and to explore whether this effect might be greater in women with a medical indication for epidural analgesia during labour, or with preterm labour.