tbuckley/cabot-search huggingface dataset:
Etiology of Backache in Medical Practice
Authors: George L. Lambright
Journal: Annals of Internal Medicine (1929)

Article1 February 1929Etiology of Backache in Medical PracticeGEORGE L. LAMBRIGHT, M.D., F.A.C.P.GEORGE L. LAMBRIGHT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-8-807 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen I was asked to discuss backache from a medical standpoint it was understood that the discussion was to be limited to those aches which are experienced in the lumbar and sacral regions. My remarks will be confined to this locality.Backache, like headache, fever, and blood pressure is a symptom, and may require considerable investigation on the part of the physician before its cause is ascertained. All of us realize that there are a large number of causes. Fortunately other symptoms are commonly associated with backache which make it appear at once only incidental to the condition. We should... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Internist's discussion of backache in symposium before Cleveland Academy of Medicine, February 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1929Volume 2, Issue 8Page: 807-809KeywordsBlood pressureEtiologyFeversHeadachesLower back painPain ePublished: 1 December 2008 Issue Published: 1 February 1929 PDF downloadLoading ...
Feature Selection for the Prediction of Translation Initiation Sites
Authors: Guo-Liang Li, Tze-Yun Leong
Journal: Genomics Proteomics & Bioinformatics (2005)

Abstract Translation initiation sites (TISs) are important signals in cDNA sequences. In many previous attempts to predict TISs in cDNA sequences, three major factors affect the prediction performance: the nature of the cDNA sequence sets, the relevant features selected, and the classification methods used. In this paper, we examine different approaches to select and integrate relevant features for TIS prediction. The top selected significant features include the features from the position weight matrix and the propensity matrix, the number of nucleotide C in the sequence downstream ATG, the number of downstream stop codons, the number of upstream ATGs, and the number of some amino acids, such as amino acids A and D. With the numerical data generated from these features, different classification methods, including decision tree, naïve Bayes, and support vector machine, were applied to three independent sequence sets. The identified significant features were found to be biologically meaningful, while the experiments showed promising results.
Abstract 15636: Heme Oxygenase-1 is Necessary for Ischemia-Mediated Neovascularization
Authors: Kim H Chan, Jun Ni, Matthieu Guillou, Robyn Midwinter, Shisan Bao, Louise Dunn, Martin Ng, Roland Stocker
Journal: Circulation (2011)

Objectives: Heme oxygenase-1 (HO-1), an enzyme traditionally known for its role in heme catabolism, may play a vascular protective role. We hypothesized that HO-1 plays a role in ischemia-mediated ...
PROBLEMS OF PROOF IN CLAIMS FOR RECOVERY FOR DERMATITIS
Authors: Louis Schwartz
Journal: Annals of Internal Medicine (1943)

Article1 April 1943PROBLEMS OF PROOF IN CLAIMS FOR RECOVERY FOR DERMATITISLOUIS SCHWARTZLOUIS SCHWARTZSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-4-500 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWorkmen's compensation laws are designed for the purpose of reimbursing the worker for loss of earnings and cost of medical care resulting from occupational injuries or occupational diseases. This immediately brings up the question of a definition of an occupational disease.Many definitions have been given and, as is the case with most definitions, objections can be made to all of them. Among those suggested are the following:1. An occupational disease is one which occurs as a result of exposure to a recognized specific occupational hazard. It must have the accepted physical signs and symptoms of the specific disease...Bibliography1. SAPPINGTON CO: Medicolegal phases of occupational diseases, 1939, Industrial Health Book Company, Chicago. Google Scholar2. HUSSEY R: Workmen's compensation and medicine, Med. Clin. N. A., 1942, W. B. Saunders Co., Philadelphia, pp. 1035-1051. CrossrefGoogle Scholar3. TULIPAN L: Toilet-seat dermatitis, Indust. Med., 1940, ix, 303. Google Scholar4. Proceedings of the First Meeting of the Consulting Staff of the Dermatoses Investigations Section: April 20-21, 1942 (unpublished) Google Scholar5. SCHWARTZ L: Sensitivity to external irritants in industry, New York State Jr. Med., 1936, xxxvi, 1969-1976. Google Scholar6. DORLAND WA: The American illustrated medical dictionary, Eighteenth Edition, 1940, W. B. Saunders Co., Philadelphia. CrossrefGoogle Scholar7. SCHWARTZ L: Allergic occupational dermatitis, Jr. Allergy, 1940, xi, 318. Google Scholar8. SCHWARTZTULIPAN LL: A text book of occupational diseases of the skin, 1939, Lea and Febiger, Philadelphia. Google Scholar9. Personal communication from National Retail Drygoods Association. Google Scholar10. SCHWARTZ L: An outbreak of dermatitis from resin fabric finishes, Jr. Am. Med. Assoc., 1940, cxv, 906-994. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland*Received for publication February 2, 1943.From the Division of Industrial Hygiene, Dermatoses Investigations Section, National Institute of Health.†Medical Director, U. S. Public Health Service. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1943Volume 18, Issue 4Page: 500-517KeywordsMedical servicesPrevention, policy, and public healthSigns and symptomsSkin diseases ePublished: 1 December 2008 Issue Published: 1 April 1943 PDF downloadLoading ...
Prognostic Significance and Phenotypic Manifestations of MYC/BCL2 Protein Expression in Diffuse Large B-Cell Lymphoma (DLBCL) with Extranodal Organ Involvement: A Report of the International DLBCL Rituximab-CHOP Consortium Program Study
Authors: Anusha Madadi, Meghana Raghavendra, Shimin Hu, Zijun Y. Xu-Monette, Carlo Visco, Alexander Tzankov, Santiago Montes-Moreno, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Cherie H. Dunphy, Eric D. Hsi, Frank X. Zhao, William W. L. Choi, Xiaoying Zhao, Joannes H.J.M. Van Krieken, Jooryung Huh, Qin Huang, Wei Ai, Maurilio Ponzoni, Andrés J.M. Ferreri, Fan Zhou, Jane N. Winter, Miguel Piris, Michael B. Møller, L. Jeffrey Medeiros, Ronald S. Go, Ken H. Young
Journal: Blood (2012)
Abstract 5314: A Critical Role for TGF-{beta} Activity in the Protection Against Aortic Aneurysm Formation and Complications in Adult Mice
Authors: Yu Wang, Hafid Ait-Oufella, Olivier Herbin, Philippe Bonnin, Bhama Ramkhelawon, Soraya Taleb, Jin Huang, Georges Offenstadt, Christophe Combadiere, Laurent Renia, Jason L Johnson, Pierre-Louis Tharaux, Alain Tedgui, Ziad Mallat
Journal: Circulation (2009)

Complicated abdominal aortic aneurysm is a major cause of mortality in elderly men. Recent studies unexpectedly showed that increased angiotensin II (AII)-dependent transforming growth factor (TGF)...
A multi-institutional prospective observational study of stereotactic radiosurgery (SRS) for patients with multiple brain metastases (BMs): Updated results of the JLGK0901 Study—Long-term results of irradiation-related complications and neurocognitive function (NCF).
Authors: Masaaki Yamamoto, Toru Serizawa, Yoshinori Higuchi, Yasunori Sato, Jun Kawagishi, Kazuhiro Yamanaka, Takashi Shuto, Atsuya Akabane, Hidefumi Jokura, Shoji Yomo, Osamu Nagano, Hidefumi Aoyama
Journal: Journal of Clinical Oncology (2015)

2020 Background: The JLGK0901 study (UMIN ID; 000001812) showed the non-inferiority of SRS alone as initial treatment for patients with 5-10 BMs as compared to those with 2-4 in terms of overall survival as well as most secondary endpoints (Lancet Oncol 2014;15:387-95). However, a study weakness was that observation periods were not long enough to allow confirmation of the long-term safety of SRS alone in patients with 5-10 BMs. Methods: This was a prospective observational study of SRS-treated patients with 1-10 newly-diagnosed BMs enrolled at 23 facilities between 3-1-2009, and 2-15-2012. Results: The 1194 eligible patients (471 females, 723 males, mean age; 66 [range; 30-91] years), enrolled from March 2009 to February 2012, were categorized into three tumor number groups, i.e., A; 1 (455), B; 2-4 (531) and C; 5-10 (208). During observation periods ranging from 0.3 to 67.5 (median; 12.0, IQR; 5.8-26.5) months as of the end of 2014, SRS-induced complications occurred in 145 patients (12.1%) with the median post-SRS period being 9.3 (IQR; 4.1-17.4) months; 46, 54, 29, 11, and 5 for CTCAE grades 1, 2, 3, 4, and 5, respectively. Cumulative incidences of complications determined with a competing risk analysis (group B vs C) were 8.3% vs 5.8%, 10.9% vs 10.6%, 11.3% vs 12.1% and 12.2% vs 12.9% at the 12th, 24th, 36th and 48th post-SRS months, respectively (HR; 1.052, 95% CI; 0.666-1.662, p = 0.829). NCF maintenance (MMSE decrease < 3 from baseline) rates of groups A/B/C were 92%/91%/89% (p = 0.69), 90%/96%/88% (p = 0.25), 94%/92%/100% (p = 0.75) and 94%/92%/100% (p = 0.51) at the 12th, 24th, 36th and 48th post-SRS months, respectively. These statistical results were confirmed to be similar even with missing data analyses. Conclusions: There were no significant differences in the incidences of post-SRS complications and NCF maintenance between groups B and C. We conclude that the already-reported non-inferiority hypothesis of SRS alone for patients with 5-10 versus 2-4 BMs gains further support, in terms of treatment safety, from this longer-term follow-up study. Clinical trial information: 000001812.
Abstract 20476: Cardiac Myosin Heavy Chain Isoforms Are Acetylated at Lysine Residues, Resulting in Enhanced Enzymatic and Contractile Activities of the Myosin Motor.
Authors: Sadhana Samant, David S Courson, Nagalingam Sundaresan, Vinodkumar Pillai, Ronald S Rock, Sanjeev G Shroff, Mahesh P Gupta
Journal: Circulation (2010)

Background: Reversible lysine-acetylation of proteins is regulated by histone acetyl transferases and deacetylases (HDACs). Previous studies from this laboratory have shown that a class-II HDAC, HD...
RECENT ADVANCES IN U. S. PUBLIC HEALTH SERVICE METHODS
Authors: Frank V. Meriwether
Journal: Annals of Internal Medicine (1944)

Article1 May 1944RECENT ADVANCES IN U. S. PUBLIC HEALTH SERVICE METHODSFRANK V. MERIWETHER, M.D.FRANK V. MERIWETHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-5-768 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA study of the history of past wars reveals the fact that diseases do very markedly influence the course of wars. Until modern times, casualties from disease among the fighting forces far exceeded that sustained from wounds on the battlefield. The effect of disease was not limited to the fighting forces of the war zone, but affected the civilian population and the general economic condition of the countries involved. As startling as it may seem, casualties from typhoid fever in the Spanish American War far exceeded the battle casualties, and the rate of venereal diseases reached 187 per thousand men.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Read before a Regional Meeting of The American College of Physicians, Chicago, Illinois, on October 16, 1943. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1944Volume 20, Issue 5Page: 768-772KeywordsHispanic peopleMedical servicesSexually transmitted diseasesTyphoid ePublished: 1 December 2008 Issue Published: 1 May 1944 PDF downloadLoading ...
Cardiovascular Magnetic Resonance in Clinically Suspected Cardiac Amyloidosis
Authors: Holger Vogelsberg, Heiko Mahrholdt, Claudia C. Deluigi, Ali Yilmaz, Eva M. Kispert, Simon Greulich, Karin Klingel, Reinhard Kandolf, Udo Sechtem
Journal: Journal of the American College of Cardiology (2008)
Abstract 16951: Incidence, Predictors and Outcomes of Acute Myocardial Infarction in Patients With Sickle Cell Disease: A United States Population-Based Study
Authors: Rahul Pawar, Dhaval Kolte, Sahil Khera, Varun Mittal, Chandrasekar Palaniswamy, Marjan Mujib, Wilbert S Aronow, Sachin Sule, William H Frishman
Journal: Circulation (2013)

Background: Acute myocardial infarction (AMI) in patients with sickle cell disease (SCD) has been described in case reports and case series. However, the exact magnitude of this problem, its risk f...
SOME PROBATIVE ASPECTS OF THE EARLY GERMANIC CODES, CAROLINA AND BAMBERGENSIS
Authors: Samuel Polsky, Spencer Beresford
Journal: Annals of Internal Medicine (1943)

Article1 May 1943SOME PROBATIVE ASPECTS OF THE EARLY GERMANIC CODES, CAROLINA AND BAMBERGENSISSAMUEL POLSKY, SPENCER BERESFORDSAMUEL POLSKYSearch for more papers by this author, SPENCER BERESFORDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-5-841 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn february 1533, a document of unique historical importance was struck on the press of Ivo Schöffer, a printer of Mainz. As though foreshadowing its ultimate obscurity in English speaking countries, this prototype of scientific-legal proof was indifferently received and inattentively handled from its inception.1 Enacted as a statute a year earlier by the Reichstag at Regensburg under the imposing title, "Kaiser Karls des funfften und des heyligen römischen Reiches peinlich Gerichtsordnung," it is perhaps better known as the Carolina Code, or the Penal Laws of Chas. V.2Earlier in the 1500's had appeared another code, the Bambergensis. This work,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cambridge, Massachusetts*Received for publication March 9, 1943.†Research Students, Harvard Law School, Cambridge, Mass. Mr. Beresford is now an Ensign in the Naval Forces of the United States.1Von Bar, History of Continental Criminal Law (1916), p. 44, points out that not a single copy of the original was retained by the imperial officials and that there are enough errors in the writing and editorial work of the original draft as well as in the typography of the principal edition of February 1533, so that frequently it is difficult to ascertain the meaning. There is also, according to that authority, some dispute as to the existence of earlier editions.2Constit. Crim. Car V. ed. J. F. Ludovic, Halle 1716. Further references to this code are by way of our own translation from the original German.3Article CXLVII of the Penal Laws (Carolina Code) and Article CLXXIII of the Bamberger Code are identical except for (1) punctuation and spelling, the Bamberger Code being written apparently in older German, (2) the addition in the Penal Laws of the words "and the fracas" ("und Rumor") after the word "blow" and before the words "and how long he lived after he was 'struck,'" and (3) the more formal ending of the Article of the Penal Laws which concludes, "and the judge shall, in accordance with his understanding of the law, and the authorities and purpose of the law, and the purpose of this enactment, give due consideration to such testimony." PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExpert scientific evidence under the adversarial system. A travesty of justice? 1 May 1943Volume 18, Issue 5Page: 841-845 Issue Published: 1 May 1943 PDF downloadLoading ...
Renal Improvement in Myeloma with Plasma Exchange
Authors: Colin Hutchison, Franck Bridoux, Jean-Paul Fermand
Journal: New England Journal of Medicine (2011)

To the Editor: Burnette et al. (June 16 issue)1 evaluated bortezomib-based chemotherapy and plasma exchange for the management of myeloma kidney. The reported renal recovery rate of 86% will probably lead to improved patient survival. However, interpretation of these results should be approached with caution. The authors’ principal finding confirmed that of a previous study showing that an early reduction in concentrations of serum free light chains is associated with renal recovery.2 The authors did not show the relative contribution of plasma exchange to the achievement of this reduction. Previous studies have shown the inability of plasma exchange to provide a meaningful magnitude of free light-chain removal, as compared with extended high-cutoff hemodialysis.3 In addition, the only large controlled trial of plasma exchange involving these patients did not show a clinical benefit.4 Therefore, the early reduction of levels of free light chains probably represents the efficacy of the chemotherapy rather than the plasma exchange. Controlled studies assessing the additional benefit of plasma exchange beyond effective chemotherapy, similar to the ongoing trials EULITE (European Trial of Free Light Chain Removal by Extended Haemodialysis in Cast Nephropathy; Current Controlled Trials number, ISRCTN45967602) and MYRE (Studies in Patients with Multiple Myeloma and Renal Failure Due to Myeloma Cast Nephropathy; ClinicalTrials.gov number, NCT01208818) assessing extended hemodialysis, are warranted before any clinical recommendations can be made.
The monocytic component of acute myelomonocytic and monocytic/monoblastic leukemias is detectable by a chemiluminescent assay
Authors: Luiz Marcos da Fonseca, Iguatemy Lourenço Brunetti, A. Campa, L. H. Catalani, R. T. Calado, R. P. Falcao
Journal: Blood (2002)
All you need is cognitive behaviour therapy?
Authors: T. Sensky
Journal: BMJ (2002)

All you need is cognitive behaviour therapy? Critical appraisal of evidence base must be understood and respectedEditor-The article by Holmes and the accompanying commentaries essentially aim to explore the evidence for the efficacy and effectiveness of the psychotherapies and how this should be applied in everyday clinical practice. 1It is ironic that the arguments against cognitive therapy include numerous instances of idiosyncratic use of research evidence.Firstly, for example, in his commentary Bolsover selects three studies to support his view that the evidence base for cognitive therapy is weak.We would challenge him to apply his arguments to the seven systematic reviews of cognitive therapy in the Cochrane Database and the Database of Abstracts of Reviews of Effectiveness. 2 Holmes and also Bolsover cite a single paper to suggest that cognitive therapy is less effective in the real world of clinical practice than in university based clinical trials.This caricature may have applied to some trials conducted 30 years ago but is irrelevant now.To give just two examples, recent trials of cognitive therapy for chronic depression specifically recruited individuals who were depressed despite adequate trials of pharmacotherapy and psychotherapy. 3Also, the Cochrane review of cognitive therapy for schizophrenia includes examples of "real world" interventions. 4 Holmes argues that leading cognitive therapists are starting to question aspects of their discipline.However, these critiques are quoted out of context; the criticisms actually refer to the need to adapt the basic cognitive model to enhance its effectiveness for other disorders.Far from being a weakness, the critical appraisal of cognitive therapy by its practitioners is an important reason why it has been systematically evaluated in such a wide range of conditions.We agree with Holmes that it is unhelpful to evaluate psychotherapies by using only the research methods applied to drug trials.If clinicians and researchers aspire to an evidence based health service, however, they must accept two challenges.First is the challenge of evaluating what they think they do.We look forward to the evidence base of the psychodynamic psychotherapies developing, to allow more valid comparisons between the different approaches.Until then there is no escaping the robust evidence that exists for the use of cognitive therapy across clinical conditions and settings and the fact that much of this research is clearly applicable to the NHS.The second challenge is for clinicians and commentators to understand and respect the critical appraisal of the evidence base.Regrettably, some of the contributors to this series of articles have failed in this.
Public Reporting of Patient Satisfaction vs Objective Quality Measures
Authors: Elliott R. Haut
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
O058 : Increased cancer rates in patients with chronic hepatitis C: An analysis of the cancer registry in a large U.S. health maintenance organization
Authors: A.H. Nyberg, J.W. Chung, J.M. Shi, T.C. Cheetham, K.M. Chiang, R. Haque, Z.M. Younossi, L.M. Nyberg
Journal: Journal of Hepatology (2015)