THE HYPERTENSINASE CONTENT OF PLASMA OF NORMAL, HYPERTENSIVE AND NEPHRECTOMIZED DOGS
Authors: Lewis Dexter
Journal: Annals of Internal Medicine (1942)

Article1 September 1942THE HYPERTENSINASE CONTENT OF PLASMA OF NORMAL, HYPERTENSIVE AND NEPHRECTOMIZED DOGSLEWIS DEXTER, M.D.LEWIS DEXTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-3-447 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe pressor substance, hypertensin, was demonstrated by Braun-Menendez, Fasciolo, Leloir, and Muñoz1, 2, 3, 4of this Institute in the renal venous blood of ischemic kidneys and was shown to be identical with the pressor substance produced by the in vitro incubation of renin with blood globulins (hypertensin precursor) and unlike other known pressor substances. They concluded, therefore, that hypertensin is the pressor substance responsible for hypertension due to renal ischemia. Braun-Menendez and his collaborators2, 3, 4, 5likewise described a substance, hypertensinase, which destroys or inactivates hypertensin. Its distribution in the body, a method of its extraction from tissues,...Bibliography1. BRAUN-MENENDEZFASCIOLOLELOIRMUÑOZ EJCLFJM: La substancia hipertensora de la sangre del riñon isquemiado, Rev. Soc. argent. de biol., 1939, xv, 420. Google Scholar2. MUÑOZBRAUN-MENENDEZFASCIOLOLELOIR JMEJCLF: Hypertensin: the substance causing renal hypertension, Nature, 1939, cxliv, 980. CrossrefGoogle Scholar3. BRAUN-MENENDEZFASCIOLOLELOIRMUÑOZ EJCLFJM: The substance causing renal hypertension, Jr. Physiol., 1940, xcviii, 283. CrossrefGoogle Scholar4. MUÑOZBRAUN-MENENDEZFASCIOLOLELOIR JMEJCLF: Mechanism of renal hypertension, Am. Jr. Med. Sci., 1940, cc, 608. CrossrefGoogle Scholar5. FASCIOLOLELOIRMUÑOZBRAUN-MENENDEZ JCLFJME: La hipertensinasa: su dosaje y distribución, Rev. Soc. argent. de biol., 1940, xvi, 643. Google Scholar6. BRAUN-MENENDEZFASCIOLOLELOIRMUÑOZ EJCLFJM: Farmacologia de la hipertensina, Rev. Soc. argent. de biol., 1940, xvi, 398. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication December 13, 1941.From the Department of Physiology, Faculty of Medical Sciences, Buenos Aires, Argentina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKidney Enzymes and Essential HypertensionProcessing of Angiotensin and Other Peptides by the LungsThe Fate of Angiotensin IICatabolism of Angiotensin IIEnzymes that Inactivate Vasoactive PeptidesInactivation of Angiotensin II Analogues by Isolated Perfused Rat Liver and KidneyZum Angiotensin-Abbau bei experimenteller HypertonieUntersuchungen �ber die Serum-AngiotensinaseUntersuchungen �ber die Angiotensinase im Serum Gesunder und KrankerHypertonieHypertonieDie Klinik und Chemie der Proteinasen des menschlichen und tierischen Organismus, ihre besondere Bedeutung in seinen Abwehrleistungen und in der klinischen DiagnostikMechanisms of human hypertensionThe Renal Pressor System and Experimental and Clinical Hypertension 1 September 1942Volume 17, Issue 3Page: 447-450KeywordsBloodBlood plasmaGlobulinsHypertensionKidneysRenal ischemia ePublished: 1 December 2008 Issue Published: 1 September 1942 PDF downloadLoading ...