tbuckley/cabot-search huggingface dataset:
Live 3-Dimensional Transesophageal Echocardiography
Authors: Lissa Sugeng, Stanton K. Shernan, Ivan S. Salgo, Lynn Weinert, Doug Shook, Jai Raman, Valluvan Jeevanandam, Frank DuPont, Scott Settlemier, Bernard Savord, John Fox, Victor Mor-Avi, Roberto M. Lang
Journal: Journal of the American College of Cardiology (2008)
Improving Hospital Quality and Costs in Nonoperative Traumatic Brain Injury
Authors: Bellal Joseph, Viraj Pandit, Ansab A. Haider, Narong Kulvatunyou, Bardiya Zangbar, Andrew Tang, Hassan Aziz, Gary Vercruysse, Terence O’Keeffe, Randall S. Freise, Peter Rhee
Journal: JAMA Surgery (2015)

The role of acute care surgeons is evolving; however, no guidelines exist for the selective treatment of patients with traumatic brain injury (TBI) exclusively by acute care surgeons.We implemented the Brain Injury Guidelines (BIG) for managing TBI at our institution on March 1, 2012.OBJECTIVE To compare the outcomes in patients with TBI before and after implementation of the BIG protocol. DESIGN, SETTING, AND PARTICIPANTSWe conducted a 2-year analysis of our prospectively maintained database of all patients with TBI (findings of skull fracture and/or intracranial hemorrhage on an initial computed tomographic scan of the head) who presented to our level I trauma center.The pre-BIG group included patients with TBI from March 1, 2011, through February 29, 2012, and the post-BIG group included patients from July 1, 2012, through June 30, 2013. MAIN OUTCOMES AND MEASURESThe primary outcome measures were patients with repeated computed tomography of the head and neurosurgical consultations.Secondary outcome measures were findings of progression of intracranial hemorrhage on repeated computed tomographic scans, neurosurgical intervention, hospital admission, intensive care unit admission, hospital and intensive care unit length of stay, 30-day readmission rate, and hospital costs per patient.RESULTS A total of 796 patients (415 in the pre-BIG group and 381 in the post-BIG group) were included.There was a significant reduction (19.0%) in the rate of neurosurgical consultation (post-BIG group, 273 patients [71.7%]; pre-BIG group, 376 [90.6%];P < .001),repeated computed tomography of the head (post-BIG group, 255 patients [66.9%]; pre-BIG group, 381 patients [91.8%];P < .001),hospital (post-BIG group, 330 [86.6%]; pre-BIG group, 398 [95.9%];P < .001)and intensive care unit admission (post-BIG group, 202 [53.0%]; pre-BIG group, 257 [61.9%];P = .01),hospital length of stay (post-BIG group, 5.4 [4.5] days; pre-BIG group, 6.1 [4.8] days; P = .03),and hospital costs per patient ($4772 per patient; P = .03)with implementation of BIG.There was no difference in the in-hospital mortality rate (post-BIG group, 62 patients [16.3%]; pre-BIG group, 69 patients [16.6%];P = .89),progression of intracranial hemorrhage on repeated scans (post-BIG group, 41 patients [10.8%]; pre-BIG group, 59 patients [14.2%];P = .14),neurosurgical intervention (post-BIG group, 61 patients [16.0%]; pre-BIG group, 59 patients [14.2%];P = .48),and 30-day readmission rate (post-BIG group, 31 patients [8.1%]; pre-BIG group, 37 patients [8.9%]; P = .69)after implementation of BIG.CONCLUSIONS AND RELEVANCE Implementation of BIG is safe and cost-effective.BIG defines the management of TBI without the need for neurosurgical consultation and unnecessary imaging.Establishing a national, multi-institutional study implementing the BIG protocol is warranted.
Abstract 3915: PCI in Asymptomatic Outpatients Undergoing Cardiac Catheterization: Results from the American College of Cardiology - National Cardiovascular Data Registry (ACC-NCDR(R))
Authors: Jeptha Curtis, Yongfei Wang, Brahmajee Nallamothu, Saif S Rathore, Andrew Epstein, John Rumsfeld, Harlan M Krumholz, John Spertus
Journal: Circulation (2006)
MEDICAL PROBLEMS IN THE MIDDLE EAST
Authors: Crawford F. Sams
Journal: Annals of Internal Medicine (1944)

Article1 August 1944MEDICAL PROBLEMS IN THE MIDDLE EASTCRAWFORD F. SAMSCRAWFORD F. SAMSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-2-215 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe medical problems in the Middle East Theatre of Operations which I will mention and discuss have either been published or mentioned on the radio; otherwise I could not discuss them. For the same reason of security, as it is called in the military service, it will not be possible to give specific rates concerning the incidence of these diseases among our troops.I shall not include in this discussion anything about the fighting; or problems of evacuation of battle casualties, of which we had a considerable number in that theatre, as certain American units supported the Eighth Army in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented before the Sixth Annual Regional Meeting of the American College of Physicians in Philadelphia, November 19, 1943. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKrankheiten aus äußeren physikalischen Ursachen 1 August 1944Volume 21, Issue 2Page: 215-229KeywordsArmed forces ePublished: 1 December 2008 Issue Published: 1 August 1944 PDF downloadLoading ...
Systemic Treatment of Trichomonas Vaginalis Infestation in Women
Authors: E. Rees
Journal: BMJ (1960)

The combined oral and systemic treatment of Trichomonas vaginalis infestation in women by metronidazole l-,8-hydroxyethyl-2-methyl-5-nitroimidazole (RP 8823; "flagyl "), a derivative of nitroimidazole, has been reported by Durel et al. (1959) and Sylvestre et al. (1959).At Liverpool Royal Infirmary a clinical trial of this preparation administered systemi- cally without any concurrent local therapy was instigated in December, 1959.The preliminary results are reported.The patients taking part were women who attended the female venereal disease department either at the special clinic or at the " non-specific " clinic which is held in the gynaecological out-patient department.Patients are referred to the former by their general practitioners or other hospital departments, or attend as contacts of male cases of gonorrhoea or on their own accord.Patients are referred to the latter, as con- tacts, by male cases of non-specific urethritis who are attending male venereal disease clinics.In view of the variability in demonstrating tricho- monads on examination of wet preparations in the carrier type of case, treatment was limited initially to cases showing an acute infestation, in order that an immediate clinical assessment could be made.In the first four cases treated the clinical and symptomatic response was prompt.Thereafter, all those who presented and in whom trichomonads were demon- strated in wet preparations received metronidazole.Culture methods of diagnosis were not available in the clinic or the hospital laboratory, but permission was given by Professor T. N. A. Jeffcoate for cultures to be supplied and examined by his department.These were used in the follow-up of all cases treated with metron- idazole.The culture medium used was the Feinberg-Whittington liquid liver medium (Feinberg and Whittington, 1957).As the vaginal discharge became thick and often scanty after treatment, the specimen was collected on a swab stick, the end of which was broken off into the bottle containing the medium.This was incubated within five minutes of inoculation and examined after 24 hours.Negative cultures were re-examined after 72 hours.Centrifuging was not carried out.Trichomonads were reported present 1 +, 2 + +, or 3 + + +, according to the number present.Candida albicans was reported when found.Diagnosis was by microscopical examination of fresh preparations in normal saline in the clinic within fifteen minutes of taking.Clinically, cases were recorded as acute, subacute, or carrier according to the clinical signs present at the time of diagnosis.A full clinical examination was recorded at each attendance by the same clinician, except on a few occasions during absence on leave.In cases in which gonorrhoea was diagnosed, treatment for T. vaginalis infestation was withheld for one week after
Low dose aspirin for preventing and treating pre-eclampsia
Authors: J Emeagi, S Patni, H M Tikum, A M Mander, L. Duley, M. Sullivan, M. de Swiet, M. Elder
Journal: BMJ (1999)

Low dose aspirin for preventing and treating pre-eclampsia Author of editorial did not criticise studies' methodologyEditor-In her editorial discussing the value or otherwise of aspirin for preventing and treating pre-eclampsia Duley wonders why the small trials have such different results from the large trials. 1 We suggest the following answer.Evidence based medicine means integrating individual skill with the best available evidence from systematic research.Duley's conclusions, based on several multicentre studies, seem to rely on the conclusions of these studies without her making criticisms of the methodology used.Firstly, the timing of the start of treatment with low dose aspirin is important.The studies consistently fail to show the percentage of women who were < 16 weeks pregnant, the crucial time when maximum trophoblastic invasion is taking place (table ).This issue was raised by de Swiet in Bower's news article 2 and by Beaufilis et al. 3 Secondly, the dose of aspirin used in the later large trials is low.A meta-analysis by Leitich et al (not quoted in the editorial) shows that aspirin was more effective at higher doses (100-150 mg/day) than at lower doses (50-80 mg/day). 4It seems that these large studies have looked at the wrong dose of aspirin used at the wrong time of pregnancy.The editorial's conclusions are based on trials with flawed methodology.The question of whether aspirin given in early pregnancy in an appropriate dose is effective in preventing pre-eclampsia remains unanswered.
Risk of Bleeding With Dabigatran in 2010-2011 Medicare Data
Authors: Inmaculada Hernandez, Yuting Zhang
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
P0166 : Anticoagulation does not increase portal hypertension related bleeding, but exposes patients with cirrhosis to a high risk of minor hemorrhages. Results from a comparative cohort study
Authors: V. La Mura, S. Braham, F. Branchi, M. Moia, A.L. Fracanzani, M. Colombo, A. Tripodi, M. Primignani
Journal: Journal of Hepatology (2015)
Abstract 16825: Minimizing the Risk for Pericardial Effusion/Tamponade During LA Appendage Closure Using a Next-Generation Watchman LAA Closure Device (Preliminary Results of the European EVOLVE Registry)
Authors: Vivek Y Reddy, Petr Neuzil, Peter Sick, Horst Sievert
Journal: Circulation (2011)

Introduction: The PROTECT AF randomized trial compared Warfarin with left atrial appendage (LAA) closure using a filter device (Watchman) in atrial fibrillation (AF) pts with CHADS 2 ≥ 1. While the primary endpoint of stroke/systemic embolism/cardiovascular death favored LAA closure (RR = 0.71, 95%CI 0.44 - 1.30), there was a significantly higher risk of safety complications of LAA closure compared to control- the most frequent being peri-procedure pericardial effusion and tamponade. Herein, we report the early experience with a next generation Watchman device designed for less traumatic LAA placement. Methods: As compared to the current Watchman device, the distal tines of the next generation Watchman device are designed to deploy in a less traumatic fashion. Implantation with this next generation device was offered to AF patients with a CHADS 2 score of ≥ 1. The device was implanted in standard fashion: IV heparinization, transseptal puncture, TEE guidance. Post-implantation, patients were discharged on 6 weeks of warfarin followed by 4.5 months clopidogrel and life-long aspirin therapy. Results: Patients (n=51) were enrolled at 3 centers in Europe: age 70.9 ± 7.4 (56-83), 33% female, CHF in 33%, HTN in 86%, DM in 39%, prior stroke/TIA in 33%, Age ≥ 75 in 45%, CHADS 2 score = 2.7 ± 1.2 (1 - 6). Implantation was successful in 49/51 patients (96%). Currently, mean follow-up is 3.8 months with 5 patients followed to one year. The atraumatic distal end of the device could be inadvertently or purposefully pushed against the LAA tissue without fear of trauma; indeed there were no instances of acute or delayed pericardial tamponade. Conclusions: This very early experience reveals that modifications to this next generation WATCHMAN device have rendered it possible to implant without fear of pericardial tamponade.
Revalidating retired doctors
Authors: P. K Leaver
Journal: BMJ (2002)

Editor—The concerns expressed by Vickers over the revalidation of retired doctors are worrying if they really represent those of “the most distinguished and longserving members of our honourable profession.”1 The purpose of revalidation is to provide a mechanism for self regulation to ensure that doctors are fully competent to practise in their specified field. Doctors who are retired rapidly get out of touch, and their skills therefore become rusty.
A trio of treasurers
Authors: R. Smith
Journal: BMJ (1996)

Jack Miller



These pictures of the last three treasurers of the BMA are taken by Nick Sinclair, one of Britain's leading photographic portraitists. The BMJ commissioned the photos to mark the enormous achievement of these treasurers.

When Jack Miller, a general practitioner from Glasgow, became treasurer in 1972 the BMA was nothing like as strong financially as it is now. The association's reserves stood at £1m, and …
CONSERVATISM, THE KEYNOTE IN THE TREATMENT OF TUBERCULOSIS
Authors: C. H.  COCKE
Journal: Annals of Internal Medicine (1933)

Article1 December 1933CONSERVATISM, THE KEYNOTE IN THE TREATMENT OF TUBERCULOSISC. H. COCKE, M.D., F.A.C.P.C. H. COCKE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-6-746 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen a diagnosis of pulmonary tuberculosis has been made, the planning out of a mode of treatment entails considerably more than the immediate relief of the presenting symptoms. To attempt a finally definitive outline at once, and particularly to essay a prognosis until more is known of the case, is hazardous and will frequently bring disappointment. Hasty judgment in all medical matters is to be deplored; in tuberculosis it is to be condemned in no uncertain terms.To begin with, it must be insisted that the tuberculous patient presents a problem that is quite different from that found in most... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: C. H. COCKE, M.D., F.A.C.P.Affiliations: Asheville, North Carolina*Presented before the General Session of the American College of Physicians, 17th Annual Session, Montreal, Canada, February 8, 1933. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1933Volume 7, Issue 6 Page: 746-761 ePublished: 1 December 2008 Issue Published: 1 December 1933 PDF downloadLoading ...
Abstract 5055: The SANDS Trial: Does Aggressive Lowering of LDL-C and Non-HDL-C in Diabetes Decrease the Plasma ApoB and LDL-C Particle Number?
Authors: Barbara V Howard, Richard B Devereux, Jerome L Fleg, Wm. James Howard, Mihriye Mete, James D Otvos, Robert E Ratner, Mary J Roman, Marie Russell, Jason G Umans, Neil J Weissman
Journal: Circulation (2008)

Background: Concern has been raised that aggressive lowering of LDL-C may not be accompanied by reductions in particle number or apoB lipoprotein concentrations. The SANDS trial demonstrated that a group treated for 3 years to aggressive (AGG) targets of LDL-C ≤ 70 mg/dL and non-HDL-C ≤ 100 mg/dL had a decrease in atherosclerosis, as measured by regression of carotid intimal medial thickness (CIMT) and decreased mean arterial mass, compared with a standard group (STD) treated to LDL-C and non-HDL-C of 100 and 130 mg/dL, respectively. Methods: Participants were 499 type 2 diabetic men and women (average age 56 y) with no previous CVD events; 426 had all baseline and 36-mo lipoprotein variables. Mean baseline BMI (33kg/m 2 ), A1c (8.0%), and HDL-C (46mg/dl) did not change during the study. A standardized algorithm for lipid lowering was used in both groups; the number of hypolipidemic drugs (mean [SD]) was 1.5 [.75] and 1.2 [.73] in the AGG and STD groups, respectively. At baseline and 36 months, lipoprotein particle number (LDL-P and VLDL-P) was quantified by nuclear magnetic resonance, and plasma apoB by immunoassay. Results: There were significant decreases in apoB, LDL-P, VLDL-P, and VLDL size but not LDL size in the AGG vs STD groups. The decrease in LDL-P was reflected in all LDL fractions. In an ordered logit analyses, the probability of a decrease in CIMT was significantly related to decrease in LDL-C and separately to non-HDL-C (p &lt;.005), but not significantly related to the decrease in apoB (p =.19) and LDL-P (p =.055). Conclusion: Aggressively lowering LDL-C and non-HDL-C to targets of 70 and 100 mg/dL, respectively, was accompanied by a significant decrease in LDL-P and VLDL-P and a decline in total plasma apoB; changes in LDL-C and non-HDL-C were separately the best predictors of IMT decrease. The relationship of the associated decrease in carotid atherosclerosis to CVD events awaits longer term observation.
GASTRODUODENAL HEMORRHAGE: DIFFICULTIES IN RECOGNITION OF LESIONS AT OPERATION BY PALPATION AND INSPECTION
Authors: E M RAPPAPORT
Journal: Annals of Internal Medicine (1953)

Article1 October 1953GASTRODUODENAL HEMORRHAGE: DIFFICULTIES IN RECOGNITION OF LESIONS AT OPERATION BY PALPATION AND INSPECTIONEMANUEL M. RAPPAPORT, M.D., F.A.C.P.EMANUEL M. RAPPAPORT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-4-747 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere are few problems confronting the internist more vexing yet intriguing than that of recurrent bleeding from the upper gastrointestinal tract where repeated diagnostic studies fail to disclose the source of hemorrhage. In some cases a definitive lesion is not found despite repeated exploratory operations, and occasionally the mystery remains unsolved even at post mortem.Most frustrating and bewildering to the clinician, however, are the cases in which lesions presumed to be the cause of hemorrhage are detected by roentgenogram or gastroscopy, yet at operation the surgeon reports that "after palpation and a detailed inspection of the stomach and small...Bibliography1. FindleyKirsnerPalmer JWJBWL: Gastric cancer: difficulties in recognition at laparotomy, Gastroenterology 14: 502-508 (April) 1950. CrossrefMedlineGoogle Scholar2. JankelsonMilner IRLR: Massive upper digestive tract hemorrhage of undetermined origin, J. A. M. A. 145: 17-21 (Jan. 6) 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Jamaica, N. Y.*Received for publication March 3, 1953. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCOMMENTSThe Fluorescein String Test An Analysis of Its Use and Relationship to Barium Studies of the Upper Gastrointestinal Tract in 122 Cases of Gastrointestinal Tract HemorrhageFRED E. PITTMAN, M.D.Diagnostic Aids in Localizing the Site of Upper Gastrointestinal HemorrhageModified String Test for Determination of the Site of Upper Gastrointestinal Bleeding 1 October 1953Volume 39, Issue 4Page: 747-756KeywordsGastroenterology and hepatologyGastrointestinal tractHemorrhageLesionsStomachSurgeons ePublished: 1 December 2008 Issue Published: 1 October 1953 PDF downloadLoading ...
A BROADER VIEW OF POSTMORTEM EXAMINATIONS
Authors: Alan Gregg
Journal: Annals of Internal Medicine (1938)

Article1 August 1938A BROADER VIEW OF POSTMORTEM EXAMINATIONSALAN GREGGALAN GREGGSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-2-249 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMr. President and Gentlemen:I shall not explore the limits of your patience or abuse the courtesy of your attention by proffering in twenty minutes' time the brief of a long debate or the essence of a book. Let me rather submit to you only three scattered experiences of the past few years and conclude with a question which you are better qualified to answer than any other persons I know. The experiences may seem unrelated at first but I trust a certain coherence will be evident in due course, and I hope eagerly for as many answers later from... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Read before the American College of Physicians, New York, N. Y., April 4, 1938. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedicine as a Social Instrument: JournalismThe Case Records of the Massachusetts General Hospital 1 August 1938Volume 12, Issue 2Page: 249-252KeywordsAutopsy ePublished: 1 December 2008 Issue Published: 1 August 1938 PDF downloadLoading ...
Abstract 11546: Clinical Benefit of EDTA Chelation Therapy in Patients With Diabetes in the Trial to Assess Chelation Therapy (TACT)
Authors: Esteban Escolar, Gervasio A Lamas, Daniel B Mark, Pamela Ouyang, Allan Magaziner, Robin Boineau, Ralph Miranda, Christine Goertz, Yves Rosenberg, Richard L Nahin, Richard Nahas, Eldrin F Lewis, Lauren Lindblad, Kerry L Lee
Journal: Circulation (2013)

Chelation therapy has been used to treat atherosclerotic disease. We reported the results of an NIH-funded trial demonstrating a significant reduction of a combined cardiovascular endpoint in post-...
National research is needed
Authors: G. Teasdale, J. Bartlett, J. Pickard, A D. Mendelow
Journal: BMJ (1996)

EDITOR,—D R Jeevaratnam and D K Menon report variations in attitudes towards the care of head injured patients but seem unaware of previous and current efforts to produce the national guidelines that they call for.1 Guidelines for the initial assessment of patients and for referral to specialist units were reported a decade ago …