tbuckley/cabot-search huggingface dataset:
Chinese guidelines for ultrasound-guided thermal ablation of thyroid nodules (2024 Edition)
Authors: Zhi-Yu Han, Jian-Ping Dou, Lin Zheng, Min Xu, Jie Ren, Hui Wang, BM Shu-Rong Wang, Wei-Wei Zhan, Jian-Qiao Zhou, Shu-Hang Xu, Wen Cheng, Man Lu, Dong Xu, Jie Yu, Fei Jing, Ming-an Yu, Song-Yuan Yu, Zhi-Gang Cheng, Cheng-Zhong Peng, Ying Che, Wei-de Dai, Zu-Bang Zhou, Hong Yang, Xiao-Ping Leng, Li-Ping Sun, Guang-Bin He, Guang-Zhi He, Zhi-Bin Cong, Qin-Ying Li, Qi-Yu Zhao, Bai Nan, Cun Liu, Jia Guo, Qian Li, Qiang Wei, Gang Wang, Ying Huang, De-Sheng Sun, Tian-an Jiang, Ping Liang
Journal: International Journal of Surgery (2024)

The Chinese Guidelines for Ultrasound-guided Thermal Ablation of Thyroid Nodules (2024 edition) were jointly initiated by the Ultrasound Committee of Chinese Medical Association, the Interventional Ultrasound Committee of Chinese Association of Ultrasound in Medicine and Engineering, the Ultrasonic Intervention Committee of Chinese Colleges of Interventionalists, the Oncological Intervention Committee of Chinese Research Hospital Association, 37 multidisciplinary experts in interventional ultrasound, ultrasound medicine, endocrinology and thyroid surgery participated in the compilation of this guide, which expanded the depth and breadth of the perspective and enhanced the authority of the guide. Based on the systematic review of literatures related to ultrasound-guided thermal ablation of thyroid nodules and the professional opinions of experts, the guidelines define the indications and contraindications of thermal ablation, including pre-ablation evaluation and preparation, thermal ablation techniques and operational procedures, post-ablation follow-up, therapeutic effect evaluation, complications prevention and treatment, and the writing of medical documents for ablation. According to the Grading of Recommendations Assessment, Development and Evaluation (GRADE), a total of 17 objective and comprehensive recommendations were given. The publication and promotion of this guideline will play a positive role in promoting the standardization of ultrasound-guided thermal ablation of thyroid nodules.
Robotic vs. laparoscopic gastrectomy for patients with locally advanced gastric cancer: a meta-analysis of randomized controlled trials and propensity-score-matched studies
Authors: Wang Huang, Gang Tang, Hao Sun
Journal: International Journal of Surgery (2024)

Background: The role of robotic surgery for the treatment of locally advanced gastric cancer remains controversial. This meta-analysis aimed to compare the short-term outcomes between robotic gastrectomy (RG) and laparoscopic gastrectomy (LG) for patients with locally advanced gastric cancer using data collected from randomized controlled trials (RCTs) and propensity score-matched (PSM) studies. Materials and methods: We searched PubMed, Cochrane Library, Embase, and Web of Science databases for RCTs and PSM studies comparing RG and LG. Risk ratios (RRs) and mean differences (MDs) with 95% confidence intervals (CIs) were calculated. Results: Fifteen studies encompassing one RCT and 14 PSM studies were included, with a total of 5,079 patients (RG group: 2,279 patients; LG group: 2,800 patients). Although RG was associated with a longer operative time (MD, 19.82 mins), patients may benefit from reduced blood loss (MD, − 28.91 mL), shorter length of stay (MD, − 0.69 days), lower morbidity (RR, 0.82), major complications (RR, 0.71), blood transfusion rate (RR, 0.60), conversion rate (RR, 0.38), and higher number of harvested lymph nodes (MD, 3.25). There were no significant differences observed in readmission (RR, 0.89), mortality (RR, 0.75), reoperation (RR, 0.71), and R0 resection (RR, 0.99) between the groups. In addition, RG shortened the time to to first flatus (MD, − 0.38 days), the time to first liquid intake (MD, − 0.31 days), and the time to first soft diet intake (MD, − 0.20 days). Conclusions: RG seem associated with improved short-term outcomes and enhanced postoperative recovery in locally advanced gastric cancer compared to LG. In the future, RG may become a safe and effective alternative to LG. Further research is needed to investigate long-term outcomes and confirm the promising advantages of RG in locally advanced gastric cancer.
Vacuum suction catheter semi-rigid ureteroscopic laser lithotripsy for impacted upper ureteral stones: randomised controlled trial
Authors: Xing-Huan Wang, Zhong-Hua Wu, Tong-Zu Liu, Bing Li, Sheng Li, Yong-Zhi Wang, Ping Chen
Journal: International Journal of Surgery (2024)

Purpose: To evaluate the effectiveness and safety of an upgraded integrated vacuum suction catheter in semi-rigid ureteroscopic laser lithotripsy (VC-URSL) compared to traditional methods for treating impacted upper ureteral stones. Patients and Methods: This prospective, randomized controlled trial was conducted from September 2022 to March 2024 at a single center, enrolling 95 patients aged 18 to 70 years with a single radiopaque impacted upper ureteral stone. Participants were randomized into two groups: the VC-URSL group used an integrated vacuum suction catheter featuring a stainless steel stabilizing tube and a narrowed distal end to prevent obstruction, while the T-URSL group underwent standard ureteroscopic lithotripsy without vacuum assistance. Both groups utilized a holmium-YAG laser under general anesthesia. Primary outcomes included operative time, stone-free rates on the first postoperative day and after one month, and complication rates, specifically fever and stone retropulsion. Results: The VC-URSL group achieved significantly shorter operative times (37.60 ± 3.87 mins vs. 46.21 ± 7.54 mins, p &lt; 0.001) and higher initial stone-free rates (91.7% vs. 74.5%, p = 0.025) compared to T-URSL. Additionally, the VC-URSL group had fewer complications, with lower rates of fever (2.1% vs. 17.0%, p = 0.015) and stone retropulsion (6.3% vs. 21.3%, p = 0.033). Conclusions: VC-URSL offers a more effective, safer, and efficient alternative to T-URSL, enhancing outcomes while reducing complications. Further multicenter trials with larger populations are recommended for broader validation.
Oral microbiota as a biomarker for predicting the risk of malignancy in indeterminate pulmonary nodules: a prospective multicenter study
Authors: Qiong Ma, Chun-Xia Huang, Jia-Wei He, Xiao Zeng, Yu-Li Qu, Hong-Xia Xiang, Yang Zhong, Mao Lei, Ru-Yi Zheng, Jun-Jie Xiao, Yu-Ling Jiang, Shi-Yan Tan, Ping Xiao, Xiang Zhuang, Li-Ting You, Xi Fu, Yi-Feng Ren, Chuan Zheng, Feng-Ming You
Journal: International Journal of Surgery (2024)

Background: Determining the benign or malignant status of indeterminate pulmonary nodules (IPN) with intermediate malignancy risk is a significant clinical challenge. Oral microbiota-lung cancer interactions have qualified oral microbiota as a promising non-invasive predictive biomarker in IPN. Materials and Methods: Prospectively collected saliva, throat swabs, and tongue coating samples from 1040 IPN patients and 70 healthy controls across three hospitals. Following up, the IPNs were diagnosed as benign (BPN) or malignant pulmonary nodules (MPN). Through 16S rRNA sequencing, bioinformatics analysis, fluorescence in situ hybridization (FISH), and seven machine learning algorithms (support vector machine, logistic regression, naïve bayes, multi-layer perceptron, random forest, gradient-boosting decision tree, and LightGBM), we revealed the oral microbiota characteristics at different stages of HC-BPN-MPN, identified the sample types with the highest predictive potential, constructed and evaluated the optimal MPN prediction model for predictive efficacy, and determined microbial biomarkers. Additionally, based on the SHAP algorithm interpretation of the ML model’s output, we have developed a visualized IPN risk prediction system on the web. Results: Saliva, tongue coating, and throat swab microbiotas exhibit site-specific characteristics, with saliva microbiota being the optimal sample type for disease prediction. The saliva-LightGBM model demonstrated the best predictive performance (AUC = 0.887, 95%CI: 0.865-0.918), and identified Actinomyces, Rothia, Streptococcus, Prevotella, Porphyromonas , and Veillonella as biomarkers for predicting MPN. FISH was used to confirm the presence of a microbiota within tumors, and external data from a lung cancer cohort, along with three non-IPN disease cohorts, were employed to validate the specificity of the microbial biomarkers. Notably, coabundance analysis of the ecological network revealed that microbial biomarkers exhibit richer interspecies connections within the MPN, which may contribute to the pathogenesis of MPN. Conclusion: This study presents a new predictive strategy for the clinic to determine MPNs from BPNs, which aids in the surgical decision-making for IPN.
Patient-reported outcome based symptom management is a better option for early postoperative recovery after breast cancer surgery: a parallel controlled randomized clinical trial
Authors: Weiwei Wang, Xingcong Ma, Changyou Shan, Chong Du, Zhangjian Zhou, Yan Wanjun, Zhao Fang, Baobao Liang, Rui He, Yichao Chai, Guochao Mao, Yonglin Zhao, Congying Yang, Ying Yang, Tianxiao Zhang, Shuqun Zhang
Journal: International Journal of Surgery (2024)

Background: We aimed to assess the efficacy and feasibility of applying patient-reported outcome (PRO) based symptom management in the early postoperative period after breast cancer surgery. Materials and Method: Before surgery, patients diagnosed with breast cancer who met the inclusion criteria were randomly assigned in a 1:1 ratio to receive either postoperative PRO-based symptom management or usual care. All patients completed the MD Anderson Symptom Inventory-Chinese version (MDASI-C) via the electronic PRO system preoperatively, on a daily basis postoperatively, and twice weekly after discharge, for a duration up to 2 weeks. In the PRO-based care group, in addition to receiving usual care, patients whose symptoms reported by completing MDASI-C with a score of ≥ 4 will be managed symptomatically by the attending surgeon. Patients in the usual care group received routine care and their MDASI-C scores were unknown to their attending surgeon. The primary outcome was the MDASI-C score of patients at the time of discharge. Analyses were conducted in accordance with the established protocol. Results: Of the 134 participants, 67 were randomly assigned to each group. At discharge, the total score of MDASI-C scale was significantly higher in the usual care group comapred to the PRO-based care group (median [interquartile range], 22 [19] vs. 35 [36]; P = .002). The score of FACT-B scale (adjusted mean difference, 0.39; 95% confidence interval, 0.11 to 1.06; P = .009) was significantly lower in the usual care group than in the PRO-based care group during the 14 days after surgery. In the PRO-based care group, 87.2% of patients found the PRO-based symptom management approach helpful in their early postoperative recovery. Conclusion: The implementation of a PRO-based symptom management system within 2 weeks after breast cancer surgery effectively alleviates symptom burden and improves quality of life compared to usual care.
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization
Authors: Skye R S Fishbein, Anna L DeVeaux, Sakshi Khanna, Aura L Ferreiro, James Liao, Wesley Agee, Jie Ning, Bejan Mahmud, Miranda J Wallace, Tiffany Hink, Kimberly A Reske, Candice Cass, Janaki Guruge, Sidh Leekha, Sunaina Rengarajan, Erik R Dubberke, Gautam Dantas
Journal: Cell Host & Microbe (2024)

Gastrointestinal colonization by Clostridioides difficile is common in healthcare settings and ranges in presentation from asymptomatic carriage to lethal C. difficile infection (CDI). We used a systems biology approach to investigate why patients colonized with C. difficile have a range of clinical outcomes. Microbiota humanization of germ-free mice with fecal samples from toxigenic C. difficile carriers revealed a spectrum of virulence among clinically prevalent clade 1 lineages and identified candidate taxa, including Blautia, as markers of stable colonization. Using gnotobiotic mice engrafted with defined human microbiota, we validated strain-specific CDI severity across clade 1 strains isolated from patients. Mice engrafted with a community broadly representative of colonized patients were protected from severe disease across all strains without suppression of C. difficile colonization. These results underline the capacity of gut community structure to attenuate a diversity of pathogenic strains without inhibiting colonization, providing insight into determinants of stable C. difficile carriage.
Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy
Authors: Wee Loong Chin, Alistair M Cook, Jonathan Chee, Nicola Principe, Tracy S Hoang, Joel Kidman, Khaing P W Hmon, Yen Yeow, Matthew E Jones, Rui Hou, Elena Denisenko, Alison M McDonnell, Chung-Chau Hon, Jonathan Moody, Denise Anderson, Sonia Yip, Michelle M Cummins, Martin R Stockler, Peey-Sei Kok, Chris Brown, Thomas John, Steven C-H Kao, Deme J Karikios, Kenneth J O'Byrne, Brett G M Hughes, Richard A Lake, Alistair R R Forrest, Anna K Nowak, Timo Lassmann, W Joost Lesterhuis
Journal: Cell Reports Medicine (2024)

Platinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers to guide treatment decisions. Here, we combine time course RNA sequencing (RNA-seq) of peripheral blood mononuclear cells with pre-treatment tumor transcriptome data from the single-arm, phase 2 DREAM trial (N = 54). Single-cell RNA-seq and T cell receptor sequencing (TCR-seq) reveal that CD8
Cross-species analyses of thymic mimetic cells reveal evolutionarily ancient origins and both conserved and species-specific elements
Authors: Brooke D Huisman, Daniel A Michelson, Sara A Rubin, Katherine Kohlsaat, Wilson Gomarga, Yuan Fang, Ji Myung Lee, Pedro Del Nido, Meena Nathan, Christophe Benoist, Leonard Zon, Diane Mathis
Journal: Immunity (2024)
Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs
Authors: Anneka Allman, Brian T Gaudette, Samantha Kelly, Nagham Alouche, Léolène J Carrington, Eric Perkey, Joshua D Brandstadter, Riley Outen, Ashley Vanderbeck, Katlyn Lederer, Yeqiao Zhou, Robert B Faryabi, Tanner F Robertson, Janis K Burkhardt, Anastasia Tikhonova, Iannis Aifantis, Leonardo Scarpellino, Ute Koch, Freddy Radtke, Mechthild Lütge, Angelina De Martin, Burkhard Ludewig, Lena Tveriakhina, Achim Gossler, Lluc Mosteiro, Christian W Siebel, Daniela Gómez Atria, Sanjiv A Luther, David Allman, Ivan Maillard
Journal: Immunity (2024)
The blue-light receptor CRY1 serves as a switch to balance photosynthesis and plant defense
Authors: Yuhan Hao, Zexian Zeng, Minhang Yuan, Hui Li, Shisong Guo, Yu Yang, Shushu Jiang, Eva Hawara, Jianxu Li, Peng Zhang, Jiawei Wang, Xiufang Xin, Wenbo Ma, Hongtao Liu
Journal: Cell Host & Microbe (2024)
Urinary Circular RNA Panels to Detect HBV-Related Hepatocellular Carcinoma: A Multicenter, Large-Scale, Case-Control Study
Authors: Zijun Xie, Guangping Gan, Guanlin Zhou, Jiabao Zhang, Jiamin Ling, Jianhong Zhang, Yijun Zeng
Journal: Journal of the National Comprehensive Cancer Network (2024)

Purpose: More than 60% of patients with hepatocellular carcinoma (HCC) do not receive curative therapeutics due to late clinical manifestations and diagnosis. The 5-year survival rate for advanced HCC is approximately 2%. However, curative therapies for HCC detected early can improve the 5-year survival rate to &gt;70%. We aimed to identify sensitive and noninvasive biomarkers in urine for detecting HCC. Patients and Methods: For this study, 4 groups of individuals (healthy controls, patients with chronic hepatitis B [CHB], patients with hepatitis B virus [HBV]–induced liver cirrhosis, and patients with HBV-related HCC) were recruited, and each group was allocated to discovery, training, and validation phases. A total of 14 circular RNAs (circRNAs) were chosen as putative biomarkers in urine due to their differential expressions in HCC tissue and blood reported in related literature. Their expression levels in urine were measured by quantitative PCR (qPCR). Logistic regression models were created using a training cohort (n=312) and then validated using an independent cohort (n=741). Area under the receiver operating characteristic curve (AUC) was used to assess the diagnostic performances. Results: Three circRNA panels (circ_0075792, circ_0005397, and circ_0000976) were obtained with high diagnostic performances for differentiating HCC from the 3 control groups, with sensitivity &gt;80%, specificity &gt;90%, and AUC &gt;0.9. Conclusions: Urinary circRNA panels identified and validated based on these results show desirable diagnostic performances for detecting HCC, especially early HCC. Accordingly, using these biomarkers to detect early HCC will enable patients who would have otherwise missed the curative therapeutic window to benefit from optimal treatments.
The Carbon Footprint of Hospital Services and Care Pathways: A State-of-the-Science Review
Authors: Lisanne H.J.A. Kouwenberg, Eva S. Cohen, Wouter J.K. Hehenkamp, Lynn E. Snijder, Jasper M. Kampman, Burcu Küçükkeles, Arno Kourula, Marijn H.C. Meijers, Eline S. Smit, Nicolaas H. Sperna Weiland, Dionne S. Kringos
Journal: Environmental Health Perspectives (2024)

Climate change is the 21st century's biggest global health threat, endangering health care systems worldwide. Health care systems, and hospital care in particular, are also major contributors to greenhouse gas emissions.
Black Phosphorus Nanosheets Activate Tumor Immunity of Glioblastoma by Modulating the Expression of the Immunosuppressive Molecule PD-L1
Authors: Yue Xiong, Chao He, Junyang Qi, Meimei Xiong, Shuna Liu, Jingxin Zhao, Yuzhen Li, Gan Liu, Wenbin Deng
Journal: Biomaterials (2024)
The efficacy of longer-term lebrikizumab treatment in patients with moderate-to-severe atopic dermatitis who did not meet protocol-defined response criteria at week 16 in two randomized controlled clinical trials
Authors: Emma Guttman-Yassky, David Rosmarin, Marjolein de Bruin-Weller, Stephan Weidinger, Thomas Bieber, H Chih-Ho Hong, Hany Elmaraghy, Amber Reck Atwater, Evangeline Pierce, Chenjia Xu, Helena Agell, Esther Garcia Gil, Eric Simpson
Journal: Journal of the American Academy of Dermatology (2024)
Clinical features and outcome of brain abscess after introduction of CT and MRI: A meta-analysis
Authors: Jacob Bodilsen, Emilie Marie Eriksen, Mikkel Dreyer Nielsen, Lærke Storgaard Duerlund, Theis Mariager, Henrik Nielsen, Matthijs C Brouwer
Journal: Journal of Infection (2024)

To describe the clinical features and outcome of brain abscess since introduction of computerized tomography and magnetic resonance imaging.
Magnesium peroxide-based biomimetic nanoigniter degrades extracellular matrix to awake T cell-mediated cancer immunotherapy
Authors: Huisong Hao, Shengjie Sun, Yanan Fu, Simin Wen, Yingfei Wen, Yunfei Yi, Zhangwen Peng, Yixuan Fang, Jia Tang, Tianqi Wang, Meiying Wu
Journal: Biomaterials (2024)
New Studies of Juvenile Idiopathic Arthritis—Complex Genetics of Complex Diseases
Authors: Robert D. Blank
Journal: JAMA Network Open (2024)

Jingxian Fan, MS; Jian Hao, MD, PhD; Yuqiao Fu, MS; Xiaoyang Liu, MS; Hui-Qi Qu, MD, PhD; Joseph T. Glessner, PhD; Dandan Ji, MS; Wei Liu, MD; Gang Zheng, PhD; Zhiyong Ding, PhD; Shuzhong Cui, MD, PhD; Qianghua Xia, PhD; Hakon Hakonarson, MD, PhD; Wei Wei, MD; Jin Li, PhD
Radiologist Involvement in Radiation Oncology Peer Review
Authors: Ryan T. Hughes, Niema B. Razavian, Sydney Smith, Ralph B. D’Agostino, Paul M. Bunch, Janardhana Ponnatapura, Trevor J. Royce, James D. Ververs, Chandylen L. Nightingale, Kathryn E. Weaver, Michael K. Farris
Journal: JAMA Network Open (2024)

Importance Radiotherapy (RT) plan quality is an established predictive factor associated with cancer recurrence and survival outcomes. The addition of radiologists to the peer review (PR) process may increase RT plan quality. Objective To determine the rate of changes to the RT plan with and without radiology involvement in PR of radiation targets. Data Sources PubMed, Scopus, and Web of Science were queried for peer-reviewed articles published from inception up to March 6, 2024. Search terms included key words associated with PR of contoured targets for the purposes of RT planning with or without radiology involvement. Study Selection Studies reporting PR of contoured radiation targets with or without radiology involvement. Studies were excluded if they lacked full text, reported clinical trial–specific quality assurance, or reported PR without dedicated review of RT targets. Data Extraction and Synthesis Data were extracted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Titles and abstracts were screened by 2 reviewers. In the case of discordance, discussion was used to reach consensus regarding inclusion for full-text review. RT plan changes were characterized as major when the change was expected to have a substantial clinical impact, as defined by the original study. Pooled outcomes were estimated using random-effects models. Main Outcomes and Measures Primary outcome was pooled rate of RT plan changes. Secondary outcomes included pooled rates of major and minor changes to RT targets or organs at risk. Results Of 4185 screened studies, 31 reporting 39 509 RT plans were included (390 with radiology and 39 119 without). The pooled rate of plan changes was 29.0% (95% CI, 20.7%-37.2%). Radiologist participation in PR was associated with significant increases in plan change rates (49.4% [95% CI, 28.6%-70.1%] vs 25.0% [95% CI, 17.0%-33.1%]; P = .02) and in clinically relevant major changes (47.0% [95% CI, 34.1%-59.8%] vs 10.2% [95% CI, 4.6%-15.8%]; P &amp;amp;lt; .001). There was no difference in minor changes (15.2% [95% CI, 9.7%-20.6%] vs 13.8% [95% CI, 9.3%-18.3%]; P = .74). Subgroup analyses identified increases in the rates of changes to the gross tumor and planning target volumes with radiology-based PR. The highest rates of plan changes were observed in head and neck or lung cancer studies, studies performing PR prior to RT planning, and prospective studies. Conclusions and Relevance In this systematic review and meta-analysis of radiation oncology PR of contoured targets, radiologist involvement in peer review was associated with a significant increase in the rate of total and clinically meaningful changes to the RT targets with no change in minor change rates. These results support the value of interdisciplinary collaboration with radiology during RT planning.