tbuckley/cabot-search huggingface dataset:
ST SEGEMENT ELEVATIONS ON EKG IN A PATIENT WITH MASSIVE INTRACARDIAC MASS WITH NO OBSTRUCTIVE CORONARY ARTERY DISEASE
Authors: Rakesh Parchuri, Mohammed Mahdi, Rafail Beshai, Vinay Kumar Gadamidi, Ramona Mittal, Akhila Kongara, Jasjit Multani
Journal: Journal of the American College of Cardiology (2024)
A MULTIDISCIPLINARY APPROACH TOWARDS RESECTING A MOBILE, CONTINUOUS LEIOMYOMA TO THE HEART
Authors: Fatima Qamar, Marcel Gugala, Muskan Khan, Areeba Ali, Akila Bersali, Sahar Samimi, Taha Hatab, Rody Bou Chaaya, Neal S. Kleiman, Sachin S. Goel, Syed Zaid, Ross M. Reul, MAHESH RAMCHANDANI, Michael J. Reardon, Marvin Atkins
Journal: Journal of the American College of Cardiology (2024)
Derivative survival analyses: Analysis methods to derive survival outcomes for the remainder patient cohort without individual patient data
Authors: Niraj K. Shenoy
Journal: Cell Reports Medicine (2024)

It is not uncommon for industry-sponsored randomized controlled trials to publish survival curves/data for the overall patient cohort("A+B") and for a favorable subgroup ("A") pre-specified or post hoc, but not the survival curves/data for the remainder cohort("B"). Consequently, following regulatory approval of the intervention treatment for the overall patient population if the primary endpoint is met, it is common for cancer patients representing the remainder cohort (B) to be treated as per the results of the overall cohort (A+B). To overcome this important issue in clinical decision-making, this study aimed to identify methods to accurately derive the survival curves and/or hazard ratio (95% confidence interval) for the remainder cohort (B), utilizing published curves and hazard ratios (95% confidence intervals) of the overall (A+B) and favorable subgroup (A) cohorts. The analysis methods (method I and method II) presented here, termed "derivative survival analyses," enable accurate assessment of survival outcomes in the remainder cohort without individual patient data.
PATENT FORAMEN OVALE-ASSOCIATED STROKE IN A PATIENT WITH FIVE HIGH-RISK FEATURES: THE PERFECT STORM
Authors: Muhammad Raheel Awan, Mobeen Z. Haider, Krishna Prasad Kurpad, Muhammad Hasib Khalil, Mahreen Siddique, Sanjay Mehta, Mohammad Khalid Mojadidi
Journal: Journal of the American College of Cardiology (2024)
UNEXPECTED OUTPOUCHING: ASYMPTOMATIC LEFT ANTERIOR DESCENDING CORONARY ARTERY ANEURYSM WITHOUT PERCUTANEOUS INTERVENTION
Authors: Allen Hu, Matthew Antonioli, Idine Mousavi, Michelle Lee, Azka Latif, Mohamed M. Gad, Ankit Upadhyay, Steven Assalita
Journal: Journal of the American College of Cardiology (2024)
LIFESTYLE BEHAVIORS ASSOCIATE WITH GREATER REDUCTION IN CARDIOVASCULAR DISEASE RISK AMONG PEOPLE WITH ANXIETY AND/OR DEPRESSION: MEDIATED BY A REDUCTION IN STRESS RELATED BRAIN ACTIVITY
Authors: Shady Abohashem, Giovanni Civieri, Taha Ahmad, Lainie Louis-Jame, Erin Hanlon, Wesam Aldosoky, Michael Thomas Osborne, Ahmed A. Tawakol
Journal: Journal of the American College of Cardiology (2024)
PATENT FORAMEN OVALE WITH THROMBUS-IN-TRANSIT IDENTIFIED DURING EVALUATION OF AN INCIDENTAL RIGHT VENTRICULAR MASS IN A POLYTRAUMA PATIENT
Authors: Leonardo D. Villarroel, Arleen Ramirez Jimenez, Mohammed Elzeneini, Joshua Latner, Dhaval R. Naik, Thomas J. Lewandowski
Journal: Journal of the American College of Cardiology (2024)
CLINICAL AND ELECTROPHYSIOLOGICAL OUTCOMES OF LEFT BUNDLE BRANCH AREA PACING FOR CARDIAC RESYNCHRONIZATION THERAPY
Authors: Natalia Campo-Rivera, Alberto Negrete, ANDRES GOMEZ, Christian Camilo Pinilla Medina, Alvaro Herrera, Eduardo J. Echeverry, Daniela Gil Gonzalez, Carlos Sanchez, Efrain Gil
Journal: Journal of the American College of Cardiology (2024)
Circulating microbiome DNA as biomarkers for early diagnosis and recurrence of lung cancer
Authors: Haiming Chen, Yi Ma, Juqing Xu, Wenxiang Wang, Hao Lu, Cheng Quan, Fan Yang, Yiming Lu, Hao Wu, Mantang Qiu
Journal: Cell Reports Medicine (2024)

Lung cancer mortality is exacerbated by late-stage diagnosis. Emerging evidence indicates the potential clinical significance of distinct microbial signatures as diagnostic and prognostic biomarkers across various cancers. However, circulating microbiome DNA (cmDNA) profiles are underexplored in lung cancer (LC). Here, whole-genome sequencing is performed on plasma of LC patients and healthy controls (HCs). Differentially enriched microbial species are identified between LC and HC. A diagnostic model is developed, which has a high sensitivity of 87.7% and achieves an AUC of 93.2% in the independent validation dataset. Crucially, this model demonstrates the capability to detect early-stage LC, achieving a sensitivity of 86.5% for stage I and 87.1% for tumors <1 cm. In addition, we construct a cmDNA model for recurrence, which precisely predicts LC recurrence after surgery. Overall, this study highlights the significant alterations of cmDNA profiles in LC, indicating its potential as biomarkers for early diagnosis and recurrence.
THE CHRONICLES OF THE PARTIAL ANOMALOUS PULMONARY VENOUS RETURN: A SCIMITAR SYNDROME VARIANT IN A YOUNG HISPANIC MALE
Authors: Steven Alfonso Garcia Santiago, Amanda Doval, Enrique Leal, Hector L. Banchs-Vinas, Jose Maldonado, Edwin Rodriguez-Cruz, Pedro Enrique Vargas Otero
Journal: Journal of the American College of Cardiology (2024)
PRIMARY HIGH-RISK PCI IN A PATIENT WITH CONGENITALLY CORRECTED TRANSPOSITION OF GREAT ARTERIES AND DEXTROCARDIA AT 40 YEARS OF AGE
Authors: Faisal Masood, Rafath Ullah, Nathan Marzlin, Adrian M. Moran, A. Jamil Tajik, Suhail Allaqaband
Journal: Journal of the American College of Cardiology (2024)
GLOBAL BURDEN AND TRENDS OF ISCHEMIC HEART DISEASE AND ITS ATTRIBUTABLE RISK FACTORS IN 38 ORGANIZATION FOR ECONOMIC COOPERATION AND DEVELOPMENT COUNTRIES: A BENCHMARKING ANALYSIS FOR THE GLOBAL BURDEN OF DISEASE STUDY 2019
Authors: Hardik Dineshbhai Desai, JUHI PATEL, Mohit Lakkimsetti, Arushi Dhawan, KRUPA MADHU, Charmy Patel, Devang Undaviya, Danish Ahmed, Khushbu Patel, SUMIT KYADA, VISHRANT P. AMIN, Kamal Sharma, Mihir Vanodia
Journal: Journal of the American College of Cardiology (2024)
DIFFERENTIAL ASSOCIATION OF TRANSTHYRETIN KINETIC STABILITY WITH VARIANT AND WILDTYPE TRANSTHYRETIN CARDIAC AMYLOIDOSIS: THE SCAN-MP STUDY
Authors: Manuel Urina Jassir, Sergio Luis Teruya, Denise M. Fine, Natalia Sabogal, Stephen Helmke, Carlos Rodriguez, Felix Tsai, Tatiana Prokaeva, Rachel Foster, Brian Spencer, Jeff Kelly, Mathew S. Maurer, Frederick L. Ruberg
Journal: Journal of the American College of Cardiology (2024)
ARTIFICIAL INTELLIGENCE-ENABLED IDENTIFICATION OF PROXIMAL CORONARY ARTERY CALCIUM PREDICTS RISK IN ASYMPTOMATIC SUBJECTS WITH MILD CORONARY ATHEROSCLEROSIS
Authors: Jianhang Zhou, Aakash Dhananjay Shanbhag, Donghee Han, Bryan Bednarski, Damini Dey, Daniel S. Berman, Piotr Slomka
Journal: Journal of the American College of Cardiology (2024)
IMPLEMENTATION OF A HEART FAILURE AMBULATORY PROGRAM IN A DEVELOPING COUNTRY: SUMMARY OF THE FIRST 6 MONTHS METRICS
Authors: Mádelyn Raquel Valle Ramos, JOSE LUIS ALVARADO, Orlando José Durón Rivas, Melinton Miguel Lopez Ruano, Claudia Lorena Mazariegos López, Nuria Chavez
Journal: Journal of the American College of Cardiology (2024)
EFFICACY AND SAFETY OF CILOSTAZOL PLUS P2Y12 INHIBITOR COMPARED TO ASPIRIN PLUS P2Y12 INHIBITOR IN THE REDUCTION OF ADVERSE CARDIOVASCULAR EVENTS AND BLEEDING IN PATIENTS WHO HAVE UNDERGONE CORONARY ANGIOPLASTY WITH STENTING
Authors: Rossel Anjelo Ambal, Jaime Manalo Aherrera, Joyce Angeli Estrellado, Al Christopher O.S. Ramos
Journal: Journal of the American College of Cardiology (2024)
GENETIC CONTROL OF LYSOSOMAL DYSFUNCTION REPROGRAMS INFLAMMATORY STEROL METABOLISM IN PULMONARY ARTERIAL HYPERTENSION
Authors: Lloyd D. Harvey, Hee-Jung Kim, Wei Sun, Wadih El Khoury, Claudette St Croix, Ji Young Lee, Michael Pauciulo, Ankit Desai, Amy Webb, Raymond L. Benza, Stephen Chan
Journal: Journal of the American College of Cardiology (2024)
CONGENITAL LEFT VENTRICULAR ANEURYSM MIMICKING INFECTIOUS MYOCARDITIS: A DIFFICULT CLINICAL CASE SETTLED WITH CARDIAC MAGNETIC RESONANCE
Authors: Enrique C. Guerra, Jorge Alberto S. Silva Estrada, Santiago Luna-Alcala, Pavel Martinez-Dominguez, Nilda G. Espinola-Zavaleta, Itzel Estefani Rios Olivares
Journal: Journal of the American College of Cardiology (2024)
IMPORTANCE OF ONSITE URGENT CARDIAC SURGERY ACCESS IN TAVI PROCEDURES
Authors: Ioannis Kachrimanidis, Anastasios Apostolos, Andreas G. Synetos, Antonis Pitsis, Konstantinos Perreas, Panagiotis Dedeilias, Vasileios Kollias, Ioannis KANAKAKIS, Vassilis A. Voudris, Evangelos Pisimisis, Odysseas Katsaros, Nikolaos Ktenopoulos, Achilles Zacharoulis, Georgios Katsimagklis, Maria I. Drakopoulou, Georgios Karagiannakos, Christopher D. Olympios, Konstantinos P. Toutouzas
Journal: Journal of the American College of Cardiology (2024)
TAKOTSUBO SYNDROME BY A PLEASANT EMOTIONAL TRIGGER: AN UNEXPECTED BIRTHDAY PRESENT
Authors: Eder Jonathan Amaro Palomo, Braiana Ángeles Díaz Herrera, Jorge I. Garcia Espinosa, Oscar Rodrigo Aguilar Villegas, Eder Gonzalez-Macedo, Sarai Hernandez Pastrana, Nila Papaqui-Quitl, Rafael Sanez, Rodrigo Gopar-Nieto, Daniel Sierra, Diego Araiza Garaygordobil, Alexandra Arias-Mendoza
Journal: Journal of the American College of Cardiology (2024)
USE OF CARDIAC MAGNETIC RESONANCE IMAGING FOR RIGHT VENTRICULAR QUANTIFICATION IN TETRALOGY OF FALLOT WITH POST-OPERATIVE ATRIOVENTRICULAR BLOCK AND INTRATHORACIC EPICARDIAL PACEMAKER
Authors: Shruti Revankar, Victor Gonzalez, Tobias R. Schlingmann, Wilson W. Lam
Journal: Journal of the American College of Cardiology (2024)
EFFECTS OF SACUBITRIL/VALSARTAN OR VALSARTAN IN DE NOVO VS. CHRONIC HFPEF AND HFMREF: THE PARAGLIDE-HF TRIAL
Authors: Evan Murray, Derek D. Cyr, David A. Morrow, Randall C. Starling, Shelley R. Zieroth, Adrian F. Hernandez, Kristin Williamson, Serge Lepage, Marat Fudim, Akshay S. Desai, Jonathan Ward, Scott D. Solomon, Robert John Mentz
Journal: Journal of the American College of Cardiology (2024)
SUBCLINICAL LEFT VENTRICULAR DYSFUNCTION ASSESSMENT IN PATIENTS WITH ISOLATED SEVERE RHEUMATIC MITRAL STENOSIS BEFORE AND AFTER UNDERGOING PERCUTANEOUS BALLOON MITRAL VALVOTOMY
Authors: RAJA SUHAIL IQBAL, Krishnadas Kotwade, Pravat Kumar Dash, V.Ramnath Iyer
Journal: Journal of the American College of Cardiology (2024)
Functional characterization, structural basis, and protein engineering of a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis
Authors: Zilong Wang, Xueqing Du, Guo Ye, Haotian Wang, Yizhan Liu, Chenrui Liu, Fudong Li, Hans Ågren, Yang Zhou, Junhao Li, Chao He, De-An Guo, Min Ye
Journal: Acta Pharmaceutica Sinica B (2024)

Glycosylation is an important post-modification reaction in plant secondary metabolism, and contributes to structural diversity of bioactive natural products. In plants, glycosylation is usually catalyzed by UDP-glycosyltransferases. Flavonoid 2'-O-glycosides are rare glycosides. However, no UGTs have been reported, thus far, to specifically catalyze 2'-O-glycosylation of flavonoids. In this work, UGT71AP2 was identified from the medicinal plant Scutellaria baicalensis as the first flavonoid 2'-O-glycosyltransferase. It could preferentially transfer a glycosyl moiety to 2'-hydroxy of at least nine flavonoids to yield six new compounds. Some of the 2'-O-glycosides showed noticeable inhibitory activities against cyclooxygenase 2. The crystal structure of UGT71AP2 (2.15 Å) was solved, and mechanisms of its regio-selectivity was interpreted by pK a calculations, molecular docking, MD simulation, MM/GBSA binding free energy, QM/MM, and hydrogen‒deuterium exchange mass spectrometry analysis. Through structure-guided rational design, we obtained the L138T/V179D/M180T mutant with remarkably enhanced regio-selectivity (the ratio of 7-O-glycosylation byproducts decreased from 48% to 4%) and catalytic efficiency of 2'-O-glycosylation (k cat/K m, 0.23 L/(s·μmol), 12-fold higher than the native). Moreover, UGT71AP2 also possesses moderate UDP-dependent de-glycosylation activity, and is a dual function glycosyltransferase. This work provides an efficient biocatalyst and sets a good example for protein engineering to optimize enzyme catalytic features through rational design.
Reexamining COPD in Bronchiectasis: Elucidating Overdiagnosis and Outcomes from EMBARC's ROSE Criteria
Authors: Yen-Fu Chen, Jung-Yien Chien, Hao-Chien Wang, Chong-Jen Yu
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Reexamining COPD in Bronchiectasis: Elucidating Overdiagnosis and Outcomes from EMBARC's ROSE Criteria." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
When I use a word . . . The languages of medicines—chemical names
Authors: Jeffrey K Aronson
Journal: BMJ (2024)

The first efforts to introduce a systematic nomenclature for chemicals were initiated by four French chemists, proponents of the antiphlogistic theory, Guyton de Morveau, Antoine-Laurent Lavoisier, Claude Louis Berthollet, and Antoine François Fourcroy, who published a volume titled <i>Méthode de nomenclature chimique</i> in 1787, under the aegis of l'Académie des Sciences. Later efforts in the field by the Swedish chemist Baron Jöns Jacob Berzelius and the German chemists Justus von Liebig and Friedrich Wöhler were followed by the institution of international committees, begun in 1860 by the German organic chemist August Kekulé and culminating in the foundation, in 1919, of the International Union of Chemistry, which, in 1947, was renamed The International Union of Pure and Applied Chemistry (IUPAC). Today IUPAC combines the languages of chemical nomenclatures with computer language in the form of machine-readable chemical identifiers, setting international standards.
Targeting Breast Cancer Using 177Lu-Labeled Trastuzumab and Trastuzumab Fragment
Authors: Yogesh Rathore, Tamanna Lakhanpal, Sudipta Chakraborty, Rubel Chakravarty, B.R. Mittal, R.N. Santhosh Irrinki, Ishita Laroiya, Komalpreet Kaur, Jaya Shukla
Journal: Clinical Nuclear Medicine (2024)

Purpose A monoclonal antibody, trastuzumab, is used for immunotherapy for HER2-expressing breast cancers. Large-sized antibodies demonstrate hepatobiliary clearance and slower pharmacokinetics. A trastuzumab fragment (Fab; 45 kDa) has been generated for theranostic use. Patients and Methods Fab was generated by papain digestion. Trastuzumab and Fab have been radiolabelled with 177 Lu after being conjugated with a bifunctional chelating. The affinity and target specificity were studied in vitro. The first-in-human study was performed. Results The bifunctional chelating agent conjugation of 1–2 molecules with trastuzumab and Fab was detected at the molar ratio 1:10 in bicarbonate buffer (0.5 M, pH 8) at 37°–40°C. However, 2–3 molecules of bifunctional chelating agent were conjugated when DMSO in PBS (0.1 M, pH 7) was used as a conjugation buffer at a molar ratio of 1:10. The radiolabelling yield of DOTA-conjugated Fab and trastuzumab at pH 5, 45°C to 50°C, with incubation time 2.5–3 hours was 80% and 41.67%, respectively. However, with DOTAGA-conjugated trastuzumab and Fab, the maximum radiolabelling yield at pH 5.5, 37°C, and at 2.5–3 hours was 80.83% and 83%, respectively. The calculated K d of DOTAGA Fab and trastuzumab with HER2-positive SKBR3 cells was 6.85 ± 0.24 × 10 −8 M and 1.71 ± 0.10 × 10 −8 M, respectively. DOTAGA-Fab and trastuzumab showed better radiolabelling yield at mild reaction conditions. 177 Lu-DOTAGA-Fab demonstrated higher lesion uptake and lower liver retention as compared with 177 Lu-DOTAGA-trastuzumab. However, 177 Lu-DOTAGA-Fab as compared with 177 Lu-DOTAGA-trastuzumab showed a relatively early washout (5 days) from the lesion. Conclusions 177 Lu-DOTAGA-Fab and trastuzumab are suitable for targeting the HER2 receptors.
Associations of the glycaemic index and the glycaemic load with risk of type 2 diabetes in 127 594 people from 20 countries (PURE): a prospective cohort study
Authors: Victoria Miller, David A Jenkins, Mahshid Dehghan, Kristie Srichaikul, Sumathy Rangarajan, Andrew Mente, Viswanathan Mohan, Sumathi Swaminathan, Rosnah Ismail, Maria Luz Diaz, Rekha M Ravindran, Katarzyna Zatonska, Ahmad Bahonar, Yuksel Altuntas, Rasha Khatib, Patricio Lopez-Jaramillo, Afzalhussein Yusufali, Karen Yeates, Jephat Chifamba, Romaina Iqbal, Rita Yusuf, Elizabeth Catherina Swart, Hu Bo, Guoliang Han, Xiaocong Li, Khalid F Alhabib, Annika Rosengren, Alvaro Avezum, Fernando Lanas, Salim Yusuf
Journal: The Lancet Diabetes & Endocrinology (2024)
Prevalence of adolescent mental disorders in Kenya, Indonesia, and Viet Nam measured by the National Adolescent Mental Health Surveys (NAMHS): a multi-national cross-sectional study
Authors: Holly E Erskine, Joemer C Maravilla, Yohannes Dibaba Wado, Amirah Ellyza Wahdi, Vu Manh Loi, Shoshanna L Fine, Mengmeng Li, Astha Ramaiya, Frederick Murunga Wekesah, Sally Atieno Odunga, Anne Njeri, Althaf Setyawan, Yufan Putri Astrini, Rizka Rachmawati, Dao Thi Khanh Hoa, Krystina Wallis, Cartiah McGrath, Jamileh Shadid, Meaghan E Enright, Sarah J Blondell, David Lawrence, Prudence W Fisher, Harvey A Whiteford, Nguyen Duc Vinh, Siswanto Agus Wilopo, Caroline W Kabiru, Robert Wm Blum, James G Scott
Journal: The Lancet (2024)
Effects of 3 months of 10-h per-day time-restricted eating and 3 months of follow-up on bodyweight and cardiometabolic health in Danish individuals at high risk of type 2 diabetes: the RESET single-centre, parallel, superiority, open-label, randomised controlled trial
Authors: Jonas Salling Quist, Hanne Enghoff Pedersen, Marie Møller Jensen, Kim Katrine Bjerring Clemmensen, Natasja Bjerre, Trine Spragge Ekblond, Sarah Uldal, Joachim Størling, Nicolai J Wewer Albrechtsen, Jens Juul Holst, Signe Sørensen Torekov, Martin Erik Nyeland, Dorte Vistisen, Marit Eika Jørgensen, Satchidananda Panda, Christina Brock, Graham Finlayson, Martin Bæk Blond, Kristine Færch
Journal: The Lancet Healthy Longevity (2024)

Time-restricted eating (TRE) has been suggested to be a simple, feasible, and effective dietary strategy for individuals with overweight or obesity. We aimed to investigate the effects of 3 months of 10-h per-day TRE and 3 months of follow-up on bodyweight and cardiometabolic risk factors in individuals at high risk of type 2 diabetes.
MRI-guided optimisation of neoadjuvant chemotherapy duration in stage II–III HER2-positive breast cancer (TRAIN-3): a multicentre, single-arm, phase 2 study
Authors: Anna van der Voort, Fleur M Louis, Mette S van Ramshorst, Rob Kessels, Ingrid A Mandjes, Inge Kemper, Mariette J Agterof, Wim A van der Steeg, Joan B Heijns, Marlies L van Bekkum, Ester J Siemerink, Philomeen M Kuijer, Astrid Scholten, Jelle Wesseling, Marie-Jeanne T F D Vrancken Peeters, Ritse M Mann, Gabe S Sonke, E. van Leeuwen-Stok, L. van Leeuwen, H. de Graaf, J.M.G.H. van Riel, D. Houtsma, S. Vrijaldenhoven, A.W.G. van der Velden, A.L. Peerdeman, R.J. van den Brink - Schimmel, J.C. Drooger, A.L.Th. Imholz, M.W. Dercksen, J. Oulad Hadj, S.D. Bakker, A.J. van der Wouw, E.D. Kerver, G. Bouma, C. van Schaik, M. de Boer, C.M.P.W. Mandigers, R.H.T. Koornstra, A. Smals, R.C. Rietbroek, A. van der Padt - Pruijsten, M.O. den Boer, H. Bos, P.P.J.B.M. Schiphorst, B.E.P.J. Vriens, Q.C. van Rossum, J. Tol, D. Hoogwerf - Kluft, C.M.F. Kruijtzer - Schimmel, H.M. Oosterkamp, I.O. Baas, A.H.P. Dietvorst, M. Davidis - van Schoonhoven, M.A. van Dijk
Journal: The Lancet Oncology (2024)
LACK OF HEMODYNAMIC RESPONSE TO VASODILATOR STRESS IS ASSOCIATED WITH CARDIOVASCULAR EVENTS
Authors: Joanna Liang, Robert JH Miller, Bryan Bednarski, Mark Lemley, Aakash Dhananjay Shanbhag, Tali Sharir, Michael T. Hauser, Terrence D. Ruddy, Matthews B. Fish, Timothy M. Bateman, Wanda Acampa, Andrew J. Einstein, Sharmila Dorbala, Marcelo F. Di Carli, Edward James Miller, Albert J. Sinusas, Julian P. Halcox, Monica Martins, Philipp A. Kaufmann, Damini Dey, Daniel S. Berman, Piotr Slomka
Journal: Journal of the American College of Cardiology (2024)
Impact of hospitalized vaso-occlusive crises in the previous calendar year on mortality and complications in adults with sickle cell disease: a French population-based study
Authors: Jean-Benoît Arlet, Eléonore Herquelot, Ludovic Lamarsalle, Fanny Raguideau, Pablo Bartolucci
Journal: The Lancet Regional Health - Europe (2024)

BackgroundHistorically, sickle cell disease (SCD) patients experiencing frequent hospitalized vaso-occlusive crises (HVOC) have been associated with increased mortality, yet recent data reflecting the widespread use of hydroxyurea and advancements in disease management remain limited. Our study aims to assess the association between HVOC and mortality or severe complications in patients with SCD in this new treatment landscape.MethodsThis was a retrospective observational cohort study using the French national health data system. Between 01-01-2012 and 12-31-2018, all SCD patients ≥16 years old (ICD-10 codes D57.0–2) were included and followed until 12-31-2018. HVOC was defined as a hospitalization of ≥1 night with primary diagnosis of SCD with crisis, following an emergency room visit. The association between HVOC and severe complications was assessed with a Cox proportional hazards model.FindingsIn total, 8018 patients (56.6% females; 4538/8018) were included. The 2018 SCD standardized one-year period prevalence was 17.9 cases/100,000 person-years [17.4; 18.3]. The mean rate was 0.84 (1.88) HVOC/person-year. In 2018, 70% (5323/7605), 22% (1671/7605), and 8% (611/7605) of patients experienced 0, 1–2, or 3+ HVOCs, respectively. The median survival time between HVOCs was 415 days [386; 439]. Overall, 312 patients died (3.9%) with a mean age of 49.8 (19.4). Compared to patients without HVOC, the hazard ratios of death in patients with 1–2 or 3+ HVOCs the year prior to death were 1.67 [1.21; 2.30] and 3.70 [2.30; 5.93], respectively. Incidence of acute chest syndrome, pulmonary embolism, osteonecrosis, and sepsis increased with the HVOCs category, but not stroke. In 2018, 29.5% (180/611) of patients with 3+ HVOCs did not take hydroxyurea.InterpretationPatients must be closely monitored during their hospitalizations to intensify treatment and check treatment compliance. Innovative therapies are also required.FundingThe study was funded by Novartis.
Surface functionalization of exosomes for chondrocyte-targeted siRNA delivery and cartilage regeneration
Authors: Hao Zhang, Wenjing Yan, Jinhui Wang, Shuqian Xie, W. Andy Tao, Chien-Wei Lee, Xing Zhang, Guiyuan Zhang, Yufeng Liu, Dong Wei, Jing Hu, Haohan Liu, Fengying Liu, Yamei Nie, Xue Chen, Hongtao Xu, Jiang Xia, Shizhi Wang
Journal: Journal of Controlled Release (2024)