tbuckley/cabot-search huggingface dataset:
Abstract 29: Does Neighborhood Really Matter? How Where One Lives Influences Their Outcome Following Out-of-Hospital Cardiac Arrest
Authors: Jason E Buick, Joel G Ray, Alex Kiss, Katherine S Allan, Laurie J Morrison
Journal: Circulation (2011)

Introduction: Traditional Utstein factors for an out of hospital cardiac arrest (OHCA) have been extensively investigated, with numerous studies evaluating economic status for association with survival. Few studies have evaluated neighbourhood factors collectively as determinants of cardiac arrest outcomes. This will be the first multifactorial Canadian to investigate neighbourhood factors as determinants of OHCA outcomes. Hypothesis: We hypothesized that within 140 neighbourhoods in Toronto, Canada, there are neighbourhood level factors associated with survival to hospital discharge after an OHCA. Methods: A retrospective, observational study of all OHCA treated by Toronto EMS between April 2006 and March 2010. Using Geographic Information System (GIS) analysis, OHCA patients were assigned to a neighbourhood based on their residential address. Neighbourhood survival rates were calculated. Results: A total of 4408 OHCA were eligible for enrollment and contained the necessary information for GIS mapping. The mean (SD) age was 69.7 (16.4) y; 64% were male. The response time was 6.3 (3.6) min, 41.9% received bystander CPR, 16.8% occurred in a public location, 20.7% presented in a shockable rhythm, 27.7% had a ROSC and 5.3% survived to hospital discharge. Survival rates varied across all neighbourhoods: 25% of neighbourhoods had a 0% survival rate, while some had rates as high as 25% (See Figure). Conclusions: In conclusion, differences in survival following OHCA vary by neighbourhood, suggesting that a patient's home neighbourhood plays a role in outcomes. Further analyses are underway to investigate which neighbourhood factors are associated with improved survival.
Abstract 10829: The Dark Side of the Heart Unveiled: An Analysis of 926 Tricuspid Valve Surgeries
Authors: Guillaume Marquis Gravel, Denis Bouchard, Louis P Perrault, Pierre Page, Hugues Jeanmart, Philippe Demers, Michel Carrier, Raymond Cartier, Nancy C Poirier, Yves Hebert, Michel Pellerin
Journal: Circulation (2010)

Objectives: The objectives were to describe echocardiographic and clinical outcomes following tricuspid valve (TV) surgery, and to compare repair versus replacement. Methods: Between 1977 and 2008,...
Abstract 3815: Pim-1 Gene Delivery to Cardiac Progenitor Cells Prevents Long Term Cardiac Failure
Authors: Kimberlee Fischer, Weitao Wu, Christopher Cottage, Natalie Gude, Mark Sussman
Journal: Circulation (2008)

Cardiac stem cell therapy administered at the time of infarction effectively blunts cardiomyopathic damage a few weeks after treatment but long term efficacy of adoptive stem cell transfer remains largely unknown. A comparative analysis shows that long term (25 week) protection is only provided by Pim-1 modified progenitor cells whereas unmodified progenitor cells fail to provide prolonged benefits after six weeks post intramyocardial injection. After infarction mice were intramyocardially injected with saline, unmodified cardiac progenitor cells (CPC’s), or Pim-1 modified CPC’s. At a 12 week time point mice injected with Pim-1 modified CPC’s have increased EF and FS as compared to mice injected with unmodified cells (n=15 for each group). Invasive hemodynamic measurements (n=5 for each group) confirm that mice injected with Pim-1 modified CPC’s had improved performance by assessment of multiple functional criteria compared to unmodified cells. Longitudinal monitoring by echocardiography reveals that mice injected with Pim-1 modified CPC’s sustain fractional shortening and ejection fraction for up to 24 weeks whereas animals that receive unmodified cells begin to fail within 6 weeks after delivery and were not statistically different than saline injected controls after 12 weeks. In addition Pim-1 CPC injected mice had infarct sizes 52% smaller than control groups (p&lt;.02). Both saline and unmodified CPC’s groups maintained similar infarct sizes (~60% of left ventricular free wall). Confocal microscopy reveals engraftment and persistence of injected Pim-1 CPC’s into the myocardium with differentiation into multiple cardiogenic lineages giving rise to myocytes, vasculature, and endothelium Successful long term functional improvement of the heart requires the engraftment of Pim-1 genetically modified cardiac progenitor cells. Unmodified cells offer an acute ameliorative response but ultimately fail in the ability to effectively repair and maintain the function of the heart. These results support use of genetic engineering to enhance stem cell-mediated myocardial regeneration.
Abstract 3383: Pulmonary Hypertension Predicts Adverse Cardiac Events After Restrictive Mitral Annuloplasty for Functional Mitral Regurgitation and Advanced Cardiomyopathy
Authors: Satoshi Kainuma, Koichi Toda, Toshihiro Funatsu, Haruhiko Kondoh, Ken Sakakibara, Kazuhiro Taniguchi
Journal: Circulation (2009)
Abstract 2341: Myocardial Ultrasound Tissue Characterisation in Children after Kawasaki disease
Authors: Benedetta Leonardi, Vincenzo Giglio, Vincenzo Pasceri, Andrea de Zorzi, Stephen P Sanders
Journal: Circulation (2007)

Background: Reports of late follow-up of patients with Kawasaki Disease (KD), even with no epicardial coronary artery disease, have demonstrated abnormal vascular reactivity and myocardial perfusion. Left ventricular (LV) function is usually normal in KD patients during long-term follow-up. However, data regarding the myocardial properties of these children are lacking. Ultrasound tissue characterization (UTC), under some circumstances, appears to be predictive of subsequent development of myocardial dysfunction. Methods and Results: We performed UTC analysis in 22 asymptomatic KD patients, mean age 6.6±3.4 years, 17 males, with a mean follow-up of 4.8±3.4 years after the illness. Coronary aneurysms were present in 8 patients (mean age 7.8±5.3 years). Cyclic variation of integrated backscatter (cvIBS) and calibrated integrated backscatter (cIBS) were assessed in 16 LV myocardial segments. Tissue Doppler imaging (TDI) at the mitral annulus was performed to assess LV diastolic function. All UTC and TDI data were compared to 22 age-matched controls, mean age 6.6±3.4 years. All patients had normal LV systolic function and wall motion score index (WMSI) compared to controls (EF 60.3±4.0% vs 60.8±4.4%, p=0.64, WMSI 1 vs 1, p=NS respectively). Myocardial velocities in systole and diastole by TDI did not differ significantly between patients and controls. CvIBS and cIBS mean values showed significant differences, for all segments sampled, between patients and controls (7.8±0.8 dB vs 8.9±0.6 dB, p&lt;0.001, and 28.6±3.2 dB vs 25.2±1.0 dB p&lt; 0.001 respectively). Neither cvIBS nor cIBS differed significantly between patients with and without aneurysms (7.9±0.8 dB vs 7.8±0.8 dB, p=0.84, and 30.3±4.3 dB vs 27.7±2.3 dB, p=0.20 respectively). Conclusions: We detected widespread differences in myocardial physical properties between KD patients and controls late after the acute disease, despite normal LV function and independent of demonstrable coronary abnormalities. These differences could be related to cellular damage induced by occult myocardial ischemia or could represent abnormalities of small myocardial vessels. Further studies are needed to confirm these findings in a larger group of patients and to determine the clinical significance.
Abstract 9845: Efficacy and Safety of Transcranial Ultrasound and Microbubbles in Treating Acute Ischemic Stroke Without Thrombolytic Agents
Authors: Jinjin Liu, Shunji Gao, Feng Xie, John Lof, William T Shi, Francois Vignon, Jeff E Powers, Thomas R Porter
Journal: Circulation (2011)

Background. Although transcranial ultrasound (TCUS) and microbubbles (MB) have been utilized in the emergent management of stroke, it remains unclear what TCUS parameters are required to be effective. Furthermore, it is unclear whether TCUS alone, without supplemental thrombolytic agents, could produce thrombolysis without intracranial hemmorhage (ICH). The purpose of this study was to determine whether TCUS pulse sequences which elicit predominately inertial cavitation (IC) versus stable cavitation (SC) of MB would be more effective in recanalizing the cerebral vessels in acute stroke. Methods. In 24 pigs, three hour old venous thrombi were embolized into the internal carotid and middle cerebral arteries. After angiographic documentation of persistent bilateral occlusion, pigs were randomized to a continuous infusion of MB using intravenous 3% Definity, during which either guided high mechanical index (MI) impulses (2.3 MI; 5 usec pulse duration) or guided intermediate MI impulses (1.7 MI, 20 usec pulse duration) were administered. The impulses were applied only when simultaneous low MI imaging detected MB within the cortex. A third control group received high MI impulses (2.3 MI) alone without MB. All pigs received aspirin. Radiofrequency (RF) data was collected from returning signals in all pigs to determine whether noise based IC or ultraharmonic based SC were created. Microscopic analysis (Hematoxylin/Eosin) was performed to analyze for ICH post-mortem. Results. Attenuation across the pig skull (measured ex vivo) using a calibrated hydrophone was &gt;52% in all pigs. Recanalization rates were highest for guided high MI impulses in the presence of MB (8/8 versus 3/8 for guided intermediate MI impulses/MB and 4/8 for high MI TCUS alone; p&lt;0.05). Although the intermediate MI impulses created both SC and IC, a more homogenous IC field was created with guided high MI impulses in the presence of MB. Microscopic analysis of ipsilateral and contralateral cortex indicated no ICH in any pig. Conclusions. TCUS and intravenous commercially available MB are capable of safely restoring cerebral blood flow without the need for thrombolytic agents. Achieving a dominant IC field appears critical to produce thrombolysis.
Abstract 9122: Heparin Mobilizes Multipotent Human Mesoangioblasts
Authors: Keisuke Fujitaka, Masayoshi Iwasaki, Daisuke Sato, Chiharu Enoki, Haengnam Park, Masamichi Koyanagi, Naoki Minato, Hajime Otani, Mitsushige Nishikawa, Yasushi Adachi, Susumu Ikehara, Andreas M Zeiher, Stefanie Dimmeler, Toshiji Iwasaka
Journal: Circulation (2011)

The identification of clinically applicable drugs which mobilize endogenous mesenchymal progenitor cells may offer novel therapeutic application in cardiovascular diseases. We recently showed that hepatocyte growth factor (HGF) induces the mobilization of multipotent circulating mesenchymal cells that co-express endothelial markers (so-called circulating mesoangioblasts, cMABs). Since HGF only has a short half life, we investigated whether heparin might be useful to endogenously increase HGF levels thereby inducing the mobilization of cMABs. Heparin was infused in patients with coronary artery disease at a concentration of 200 U/kg (n=11 patients) and 300 U/kg (n=11 patients) and serum HGF levels were determined by ELISA. Consistent with published studies, heparin dose-dependently increased HGF levels to 34.4+1.9 in patients receiving 200U/kg heparin and 42.8+0.9 ng/ml in the patients treated with 300 U/kg. Moreover, heparin dose-dependently increased the number of circulating mesenchymal cell colonies. Patients receiving 200U/kg showed 0.30+0.12 colonies / mononuclear cells (x10 6 ). Further increasing the heparin dosage to 300U/kg increased the number of colonies to 0.63+0.17 colonies / mononuclear cells (x10 6 ). In contrast, we were never able to obtain colonies in patients receiving heparin concentrations below 100 U/kg. The mesenchymal origin of the colonies was characterised by the lack of hematopoietic progenitor cell markers CD45 and CD34. Consistent with the original characterisation of the mesoangioblasts, the colonies expressed the mesenchymal marker CD73, the HGF-receptor c-Met as well as the endothelial marker KDR. In conclusion, we demonstrate that heparin can dose-dependently mobilize mesenchymal progenitor cells in humans. These findings might open up an avenue to non-invasively obtain multipotent mesenchymal cells for therapeutic application in patients with cardiovascular disease.
A major outbreak of gastroenteritis in Réunion Island in 2012: first identification of G12 rotavirus on the Island
Authors: N Caillère, P Vilain, E Brottet, J Kaplon, K Ambert-Balay, D Polycarpe, L Filleul
Journal: Eurosurveillance (2013)

Binary file ES_Abstracts_Final_ECDC.txt matches
Abstract 20287: Optimization of the Oxygen Affinity of Hemoglobin Based Oxygen Carrier (HBOC) Can Improve Myocardial Function Following Global Ischemia
Authors: Daniel Zelinski, Yipin Zhou, Andre Palmer, Mark Angelos
Journal: Circulation (2010)

Background: In approximately 70% of cardiac arrests return of spontaneous circulation is not achieved, in part due to the inadequate re-oxygenation of the ischemic myocardium during CPR. Hemoglobin...
Il28B Genetic Polymorphism Has Genome Wide Significant Associations with Serum Low Density Lipoprotein Levels and Hepatic Steatosis in Patients with Genotype 1 Chronic Hepatitis C (Chc)
Authors: Paul J. Clark, Alexander J. Thompson, Mingfu Zhu, Qianqian Zhu, Dongliang Ge, Mark S. Sulkowski, Hans L. Tillmann, Keyur Patel, Susanna Naggie, Andrew J. Muir, Nezam H. Afdhal, Ira M. Jacobson, Rafael Esteban, Eric Lawitz, Fred Poordad, Mitchell L. Shiffman, Greg Wayne Galler, Stephen Harrison, John W. King, Paul Y. Kwo, Lisa M. Nyberg, Jonathan McCone, William M. Lee, Robert Reindollar, Reem H. Ghalib, Bradley Freilich, Zachary Goodman, Navdeep Boparai, Kenneth J. Koury, Stephanie Noviello, Lisa Pedicone, Clifford A. Brass, Janice K. Albrecht, David B. Goldstein, John G. McHutchison
Journal: Hepatology (2010)
Abstract 1121: Depression is a Stronger Correlate of Coronary Artery Disease in Women Than Men Among Young and Middle-aged Patients
Authors: Elisa Zaragoza-Macias, Riyaz S Patel, Emir Veledar, Ian J Neeland, Dee Anderson, Susmita M Parashar, Arshed A Quyyumi, Viola Vaccarino
Journal: Circulation (2009)
Abstract 342: Upregulation Of Mir-21 During Cardiac Hypertrophy Induces Down-regulation Of An Inhibitor Of The Ras-MAPK Pathway, Sprouty 2
Authors: Danish Sayed, Minzhen He, Leng-Yi Chen, Jacqueline Lypowy, Maha Abdellatif
Journal: Circulation (2007)

MicroRNA (miRNA) are ~22 ribonucleotides-long, with a potential to recognize multiple mRNA targets guided by sequence complimentarity. This class of molecules is functionally versatile, with the capacity to specifically inhibit translation, as well as, induce mRNA degradation, through targeting the 3′ untranslated regions. The levels of individual miRNA vary under different developmental, biological, or pathological conditions, thus, implicating them in normal and pathological cellular attributes. We have previously reported a miRNA signature that distinguishes pressure-overload compensatory hypertrophy by recapitulating the neonatal pattern. In that model we found that miR-21 is one of the highest differentially expressed miRNA (~8x). Thus, we hypothesized that miR-21 may contribute to the development of hypertrophy by inducing down-regulation of antagonizing genes. To experimentally test the effect of miR-21 on cardiac myocytes, we generated adenoviruses harboring primary miR-21 or, uniquely, anti-miR-21 sequences. These viruses were used to infect cultured myocytes. Interestingly, overexpression of miR-21 resulted in extensive, dose-dependent, branching (sprouting) of the cells. Computational predictions by ’TargetScanS’ identified Sprouty 1 and 2 as potential targets. Subsequently, we confirmed down-regulation of sprouty by over-expression of miR-21. Conversely, knocking down miR-21, using anti-miR-21, resulted in enhanced expression of sprouty during growth-induced conditions. Immunocytochemical staining shows that it is localized to sarcomeric structures and the nucleus. Sprouty is a known inhibitor of the Ras-MAPK signaling pathway and is, concordantly, downregulated in many forms of cancer. Notably, sprouty also negatively regulates ureteric and tracheal branching during morphogenesis. In heart, sprouty has been suggested to control myocyte size and vascularization during mechanical stress-induced ventricular remodeling. Thus, we propose that upregulation of miR-21 during cardiac hypertrophy, induces down-regulation of sprouty, which results in activation of the Ras-MAPK pathway. Moreover, down-regulation of sprouty is necessary for the increased myocyte branching observed during hypertrophy.
Abstract P82: Implementation Of New Resuscitation Guidelines Takes One-and-a-half Year
Authors: Jocelyn Berdowski, Andra Schmohl, Rudolph W Koster
Journal: Circulation (2008)

Objective- In November 2005, updated resuscitation guidelines were introduced world-wide, and will be revised again in 2010. This study aims to determine how long it takes to implement new guidelines. Methods- This was a prospective observational study. From July 2005 to January 2008, we included all patients with a non traumatic out-of-hospital cardiac arrest. Ambulance paramedics sent all continuous ECG registrations with impedance signal by modem. We excluded ECGs from patients with Return Of Spontaneous Circulation at arrival, incomplete ECG registrations, ECGs with technical deficits or with continuous chest compressions. The same guidelines needed to be used in over 75% of the registration time in order to be labeled. We classified ECGs as guidelines 2000 if the c:v ratio was 15:2, shock blocks were present and there was rhythm analysis after each shock; guidelines 2005 if the c:v ratio was 30:2, a single shock protocol was used and chest compressions was immediately resumed after shock or rhythm analysis in a no shock scenario. We accepted 10% deviations in the amount of compressions (13–17 for 2000 guidelines, 27–33 for 2005). Results- Of the 1703 analyzable ECGs, we classified 827 (48.6%) as guidelines 2000 and 624 (36.6%) as guidelines 2005. In the remaining 252 ECGs (14.8%) 31 used guidelines 1992, 137 applied guidelines 2000 with c:v ratio of 30:2 and 84 did not show distinguishable guideline usage. Since the introduction in November 2005, it took 17 months to apply new guidelines in over 80% of the cases (figure 1 ). Conclusion- Guideline changes are slowly implemented by professionals. This needs to be taken in consideration when new guideline revisions are considered.
Abstract 5905: 3', 4-Dihydroxyflavonol Reduces Infarct Size in a Porcine Acute Myocardial Infarction-Reperfusion Model
Authors: Teramoto Tomohiko, Fumiaki Ikeno, Jennifer K Lyons, Bevyn Jarrott, Owen L Woodman, Clive N May, Colleen J Thomas, Alan C Yeung, William Fearon
Journal: Circulation (2009)
Abstract P107: Restless Legs Syndrome and Self-reported Hypertension in a Large Cohort of Mexican Women
Authors: Andres Catzin-Kuhlmann, Tobias Kurth, Ruy Lopez-Ridaura, Isabelle Romieu, Martin Lajous
Journal: Circulation (2013)

Background: Restless legs syndrome (RLS) is a common movement disorder that affects quality of life and is often unrecognized. RLS has been proposed as marker for increased cardiovascular risk but ...
Randomized Comparison of Sirolimus and Paclitaxel Drug-Eluting Stents for Long Lesions in the Left Anterior Descending Artery
Authors: Anna Sonia Petronio, Marco De Carlo, Giulia Branchitta, Barbara Papini, Nicola Ciabatti, Roberto Gistri, Bernardo Cortese, Gherardo Gherarducci, Antonio Barsotti
Journal: Journal of the American College of Cardiology (2007)
Abstract 2295: A Novel Cardiac Glucose Transporter, SGLT1, Mediates Increased Glucose Uptake in PRKAG2 Cardiomyopathy
Authors: Sanjay K Banerjee, David Wang, Nuria M Pastor-Soler, Kenneth R McGaffin, Ferhaan Ahmad
Journal: Circulation (2009)

INTRODUCTION: Mutations in PRKAG2, the gene encoding the γ2 subunit of AMP activated protein kinase (AMPK), lead to a cardiomyopathy characterized by cardiac hypertrophy, increased cardiac glucose ...
Abstract 14845: Ultra-Low-Dose Contrast Computed Tomographic Angiography Protocol for Octogenarians Being Evaluated for Transcatheter Aortic Valve Replacement: Effect on Image Quality and Outcomes
Authors: Micheas Zemedkun, Troy M LaBounty, Geoffrey Bergman, S. Chiu Wong, Dolores Reynolds, Fay Y Lin, Jonathon Leipsic, Ricardo C Cury, Millie Gomez, Allison M Dunning, James K Min
Journal: Circulation (2011)

Introduction: Transcatheter aortic valve replacement (TAVR) necessitates aortoiliofemoral assessment by contrast-enhanced computed tomographic (CT) angiography to determine eligibility of a transfe...
Neurosurgical Management of Spinal Metastases Causing Cord and Cauda Equina Compression
Authors: E. Meyer
Journal: Neuro-Oncology (1980)

In the treatment of certain tumor types, neurosurgical management (laminectomy) is bound to fail. In the handling of other tumor types, expectations should focus on hormonal, radiological and cytostatic treatment; in these cases laminectomy might be of supportive value. It is of importance to bear in mind that, in the presence of severe kyphosis, laminectomy has little or no effect because the cord is taut over the gibbus and therefore cannot be decompressed by laminectomy. Another fact to be borne in mind is that laminectomy can unfavourably influence the stability of the vertebral column. The results obtained in a study from a hundred patients are very disappointing at least as far as the restoration of neurological dysfunctions is concerned. Early diagnosis is the key factor in improving results in neoplastic epidural spinal cord compression.
Early and Late Results of the Modified Fontan Operation for Heterotaxy Syndrome
Authors: Peter J. Bartz, David J. Driscoll, Joseph A. Dearani, Francisco J. Puga, Gordon K. Danielson, Patrick W. O’Leary, Michael G. Earing, Carole A. Warnes, David O. Hodge, Frank Cetta
Journal: Journal of the American College of Cardiology (2006)
Hirsutism
Authors: Robert L. Rosenfield
Journal: New England Journal of Medicine (2005)

A 19-year-old woman seeks care for slowly progressive hair growth. Since high school, she has shaved her upper lip weekly and waxed her abdomen and thighs monthly. Her menstrual periods are regular. Physical examination is unremarkable except for a body-mass index of 31 and trace hair over the abdomen and thighs, with a moderate amount over her back. There is no clitorimegaly. How should this patient be evaluated and treated?
Abstract 13647: Impact and Relation of Microvascular Obstruction and Infarct Size as Predictors for Long-Term Outcome after ST-Elevation Myocardial Infarction
Authors: Suzanne de Waha, Ingo Eitel, Steffen Desch, Georg Fuernau, Matthias Grothoff, Matthias Gutberlet, Gerhard Schuler, Holger Thiele
Journal: Circulation (2010)

Background: Data on the relation of infarct size (IS) and microvascular obstruction (MO) assessed with magnetic resonance imaging (MRI) as predictors for adverse clinical outcome after ST-elevation...
Gene Therapy for Hepatocellular Carcinoma
Authors: Dennie V. Jones
Journal: Liver Cancer (1998)

Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world, with approximately one million new cases recorded annually.1 At present, only complete surgical resection has the potential for producing a cure, and then only in a small subset of patients. Other modalities, such as radiotherapy, chemotherapy, or bioimmunotherapy, have produced response in a few patients, but it is clear that most patients derive little or no benefit from the application of such treatments. Virtually all antineoplastic therapies are associated with substantial toxicities due to the often unacceptable adverse effects on normal tissues. As a result, most patients either receive ineffective therapy, or are unable to tolerate therapy that could potentially eradicate their neoplasm. This situation justifies the evaluation of novel modalities.KeywordsGene TherapyThymidine KinaseThymidine Kinase GeneHerpes Simplex VirusGenetic TherapyThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.