tbuckley/cabot-search huggingface dataset:
Pharmacogenomics and Pharmacokinetics of Aspirin in Preeclampsia Prevention
Authors: Kenean Getaneh Tlaye, Gashaw Garedew Woldeamanuel, Kenneth Chi-Yin Wong, Lu Chen, Ruqun Zheng, Pui Kin So, Xueqin Wang, Long Nguyen-Hoang, Mei Zhong, Hon Cheong So, Bo Wah Leung, Yu Huang, Yao Wang, Liona C. Poon, Chi Chiu Wang
Journal: Circulation Research (2025)

BACKGROUND: It has become evident that some women develop preeclampsia despite aspirin. This study aimed to examine how such aspirin nonresponsiveness develops in high-risk preeclampsia pregnancies by exploring the role of genetic polymorphisms and aspirin metabolism. METHODS: The study involved pregnant women who developed preeclampsia despite low-dose aspirin and those who did not. First, we conducted a pharmacogenomic association study exploring the association of potential genetic variants with aspirin nonresponsiveness. Next, we analyzed the rate of enzymatic aspirin hydrolysis in maternal plasma. The extent of placental exposure to acetylsalicylic acid and its bioactive metabolites, that is, salicylic acid and gentisic acid, was determined by liquid chromatography-mass spectrometry. The expressions of AMEs (aspirin metabolizing enzymes), that is, GLYAT (glycine-N-acyltransferase), UGT1A6, CYP2E1, and NAT2 in the placenta, were analyzed by quantitative reverse transcription polymerase chain reaction, immunohistochemistry staining, and ELISA. Finally, the effects of AMEs were further examined on HTR-8/SVneo and human primary cytotrophoblast cells. RESULT: Our genetic study showed that single-nucleotide polymorphisms (SNPs) of genes involved in aspirin pharmacokinetics and pharmacodynamics were not associated with aspirin nonresponsiveness in preeclampsia. Rates of aspirin hydrolysis in maternal plasma and the concentrations of acetylsalicylic acid, salicylic acid, and gentisic acid in the placenta did not differ between aspirin-responsive and aspirin-nonresponsive women. Intriguingly, GLYAT was significantly upregulated in the aspirin-nonresponsive placenta and associated with aspirin nonresponsiveness. This overexpression of GLYAT was found to diminish the proangiogenic, anti-inflammatory, and antisenescence effects of salicylic acid in HTR-8/SVneo and human primary cytotrophoblast cells. CONCLUSIONS: Our study revealed that maternal genetic factors and plasma aspirin hydrolysis are not among the decisive factors in determining the effectiveness of low-dose aspirin in preventing preeclampsia among high-risk women. Instead, placental GLYAT appears to play a key role by limiting the effect of salicylic acid in the placenta.
FRI-373 Calciprotein crystallization assay as calcification biomarker in metabolic-dysfunction associated steatotic liver disease population
Authors: Joyce Xu, Stan Driessen, Koen van Son, Joost PH Drenth, Maarten Tushuizen, Robert de Jonge, Marc Vervloet, A.G. (Onno) Holleboom, Henrike Hamer
Journal: Journal of Hepatology (2025)
SAT-341 Propranolol for primary prophylaxis for variceal bleed in infants and children with biliary atresia – results of a single blind placebo controlled randomized controlled trial (BABB-Trial)
Authors: Anmol Anmol, Rajeev Khanna, Seema Alam, Vikrant Sood, Bikrant Bihari Lal
Journal: Journal of Hepatology (2025)
SAT-038 Atherosclerotic cardiovascular disease risk in chronic hepatitis C patients with metabolic dysfunction-associated steatotic liver disease after viral eradication: a multi-center cohort study
Authors: Wan-Long Chuang, Pei-Chien Tsai, Jee-Fu Huang, Ming-Lun Yeh, Chung-Feng Huang, Chiayen Dai, Ming-Lung Yu
Journal: Journal of Hepatology (2025)
WED-026 Development of a predictive model using artificial intelligence (AI) for the detection of hepatitis C based on real-world data from the population health database (BPS) of Andalusia, Spain
Authors: Carlos Loucera, Carmen Lara-Romero, Victor De La Oliva, Ana Lucena Valera, Raquel Millan, Alberto Esteban-Medina, Joaquín Dopazo, Manuel Romero-Gómez
Journal: Journal of Hepatology (2025)
THU-511 Evaluation of the utility of the Nora-hepatitis B mobile application: a comparative study between chronic infection and HBeAg-negative chronic hepatitis
Authors: Judit Romero-Vico, Anna Feliu, Elena Vargas-Accarino, Ester Sánchez-Gavilán, Marc Ribó, Adriana Palom, Juan Carlos Ruiz-Cobo, Núria Fabrellas, Mar Riveiro, Maria Buti
Journal: Journal of Hepatology (2025)
THU-510 Impact of hepatitis delta infection on quality of life: results from the Nora-hepatitis B study
Authors: Judit Romero-Vico, Anna Feliu, Elena Vargas-Accarino, Ester Sánchez-Gavilán, Marc Ribó, Adriana Palom, Juan Carlos Ruiz-Cobo, Núria Fabrellas, Mar Riveiro Barciela, Maria Buti
Journal: Journal of Hepatology (2025)
WED-039 A comparative study on liver disease severity and comorbidity profile in patients with chronic hepatitis B virus infection and hepatitis B virus/hepatitis D virus co-infection: a korean nationwide study
Authors: Heejoon Jang, Hoyoung Na, Hazel Shin, Julie Lee, Jinhye Cha, Bo Ok Kim, Helin Han, Yun Bin Lee
Journal: Journal of Hepatology (2025)
WED-007 Implementation of a multicenter reflex testing program for hepatitis D detection of and registration of positive cases in Catalonia
Authors: Adriana Palom, Ariadna Rando-Segura, Laura Calatayud-Samper, Gema Fernández-Rivas, Alicia Sellés-Sanchez, Saray Mormeneo-Bayo, Dúnia Pérez del Campo, Eva del Corral, Josefina Ayats, David Tabernero, José Castellote Alonso, Rosa M Morillas, Adrià Rodríguez-Castellano, Patricia Huelin, Carmen López Núñez, Darly Salazar, Joana Villaverde, Andrés Marco, Maria Buti
Journal: Journal of Hepatology (2025)
SAT-433-YI Multidisciplinary management combining hepatologist counseling, cognitive/behavioral therapy, and nutritional support (the “CoCoNut” protocol) significantly improves metabolic and clinical outcomes of MASLD patients
Authors: Mario Romeo, Marcello Dallio, Fiammetta Di Nardo, Annachiara Coppola, Paolo Vaia, Carmine Napolitano, Alessia Silvestrin, Marco Niosi, Alessandro Federico
Journal: Journal of Hepatology (2025)
SAT-417-YI Sex disparities in response to low-carb, high-fat diet in MASLD
Authors: Ellen Elise Petersen, Johanne Kragh Hansen, Nikolaj Torp, Katrine Lindvig, Peter Andersen, Stine Johansen, Ida Falk Villesen, Katrine Bech, Katrine Thorhauge, Helle Schnefeld, Sönke Detlefsen, Maja Thiele, Mads Israelsen, Camilla Dalby Hansen, Aleksander Krag
Journal: Journal of Hepatology (2025)
SAT-448 A 10-week, randomized, double blind, placebo-controlled exploratory proof of concept study of Utreglutide (GL0034) in individuals with overweight and obesity
Authors: Rajamannar Thennati, Vinod Burade, Muthukumaran Natarajan, Pradeep Shahi, Ravishankara Nagaraja, Paolo Battisti, Thierry Duvauchelle, Bernard Thorens, Richard E Pratley, Tina Vilsbøll, Rohit Loomba
Journal: Journal of Hepatology (2025)
SAT-024 Semi-qualitative feedback from individuals living with HBV newly diagnosed in the emergency department ED opt-out testing program – high acceptability but better platforms of advocacy and support required
Authors: Mia Olsen, Kosh Agarwal, Kathryn Oakes, Esther Dennis-Nkeki, Rachel Hill-Tout, Geoffrey Dusheiko, Pamela Rice, Teresa Bowyer, Ivana Carey, Rachel Halford, Kate Childs, Supa Chantschool
Journal: Journal of Hepatology (2025)
FRI-406 A quantitative systems pharmacology model identifies mechanisms attenuated by knockdown of HSD17B13 expression and associated with a reduction in hepatocellular ballooning
Authors: Mario Giorgi, Brandon Swift, Scott Siler, Vinal Lakhani, Mark Harpel, Sumanta Mukherjee, Marc Goldfinger, Itziar Irurzun, Hardik Chandasan, Stephen Atkinson, Nikhil Vergis, Anna Sher
Journal: Journal of Hepatology (2025)
SAT-408 Effectiveness of bariatric surgery versus glucagon-like peptide-1 receptor agonists for prevention of adverse cardiovascular outcomes among patients with metabolic dysfunction-associated steatotic liver disease, diabetes, and obesity
Authors: Arunkumar Krishnan, Diptasree Mukherjee, Faisal Abaalkhail, Waleed K Al-Hamoudi, Saleh A Alqahtani
Journal: Journal of Hepatology (2025)
WED-511 FIB-4 for identifying chronic liver disease patients requiring HCC surveillance
Authors: Jan Embacher, Georg Semmler, Mathias Jachs, Lorenz Balcar, Paul Thöne, Christian Sebesta, Nina Dominik, Georg Kramer, Benedikt Hofer, Lukas Hartl, Benedikt Simbrunner, Bernhard Scheiner, Matthias Pinter, Michael Trauner, Thomas Reiberger, Mattias Mandorfer
Journal: Journal of Hepatology (2025)
SAT-423 Survodutide, a glucagon/GLP-1 receptor dual agonist, in people with MASH with moderate-to-advanced liver fibrosis (stage F2-F3): rationale and design of an event-driven, multinational, randomised, placebo-controlled, phase 3 trial (LIVERAGETM)
Authors: Jörn M. Schattenberg, Mazen Noureddin, Naim Alkhouri, Luiza Borowska, Daniel F. Mazo, Martina Brueckmann, Mandy Fraessdorf, Samina Ajaz Hussain, Ramy Younes, Arun J. Sanyal
Journal: Journal of Hepatology (2025)
WED-323 Fazirsiran for alpha-1 antitrypsin deficiency-associated liver disease: long-term efficacy and safety results from a phase 2 extension study
Authors: Pavel Strnad, Gourab Choudhury, William J.H. Griffiths, Mattias Mandorfer, Jeffrey H. Teckman, Christian Trautwein, Nirav K. Desai, Susana Gonzalez, James Hamilton, Seth Pixton, Thomas Schluep, Lisi Wang, Anne E. Wyman, Yanwei Zhang, Rohit Loomba
Journal: Journal of Hepatology (2025)
FRI-413 Hepatoprotective effects of fatty acid synthase inhibitor TVB-3664 in the GAN diet-induced obese and biopsy-confirmed mouse model of MASH
Authors: Michael Feigh, Kristoffer Voldum-Clausen, Malte H. Nielsen, Jacob Nøhr-Meldgaard, Susanne Pors, Henrik B. Hansen
Journal: Journal of Hepatology (2025)
WED-416 Establishing a training protocol for liver stiffness measurement by transient elastography in metabolic dysfunction-associated steatotic liver disease screening
Authors: Faisal Abaalkhail, Shadan AlMuhaidib, Faisal M Sanai, Duna Barakeh, Haifa F Alotaibi, Saleh Alessy, Ali Hazazi, Sahar Alnasrallah, Alaa AlGhamdi, Abdulmohsin Alshammari, Bandar Aljudaibi, Waleed S Alomaim, Waleed Al-Hazzani, Saleh A Alqahtani
Journal: Journal of Hepatology (2025)
WED-493 Evaluating noninvasive tests for significant fibrosis in a population-based MASLD cohort: insights from NHANES 2017– 2020
Authors: Winston Dunn, Terry Cheuk-Fung Yip, Leon Adams, Nipun Verma, Vincent Wai-Sun Wong, Laurent Castera, Manal F. Abdelmalek, Ashwani K. Singal, Nicholas Dunn, Vincent Chen, Grace Lai-Hung Wong, Syed-Mohammed Jafri, Juan Pablo Arab, Julie Dubourg, Ajay Kumar Duseja, Wamda Ahmed, Luis Antonio Diaz, Bihui Zhong, Naim Alkhouri
Journal: Journal of Hepatology (2025)
WED-481 Advanced metabolic-dysfunction associatedsteatotic liverdisease fibrosis: low number-needed-to screen in multiple lines of care
Authors: Stan Driessen, Koen van Son, Gerlinde Haverkamp, Maaike J. Denters, Sara-Joan Pinto, Nordin Hanssen, Manuel Castro Cabezas, R. Bart Takkenberg, Henk Schers, Max Nieuwdorp, Joost PH Drenth, Maarten Tushuizen, A.G. (Onno) Holleboom
Journal: Journal of Hepatology (2025)
WED-479 Assessment of the metabolic dysfunction-associated steatohepatitis resolution index and component biomarkers in prediction of histology response to denifanstat in the FASCINATE2 trial
Authors: Rohit Loomba, Wen-Wei Tsai, Laura Hover, Shipra Gupta, Katharine Grimmer, Julie Dubourg, Eduardo Martins, George Kemble, Marie O’ Farrell
Journal: Journal of Hepatology (2025)
Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster
Authors: Maheva Andriatsilavo, Carolina Barata, Eric Reifenstein, Alexandre Dumoulin, Tian Tao Griffin, Suchetana Bias Dutta, Esther T Stoeckli, Max von Kleist, P Robin Hiesinger, Bassem A Hassan
Journal: Nature Neuroscience (2025)
A population-based analysis of the molecular landscape of glioma in adolescents and young adults reveals insights into gliomagenesis
Authors: Julie Bennett, Adrian B Levine, Liana Nobre, Logine Negm, Jiil Chung, Karen Fang, Monique Johnson, Martin Komosa, Stacey Krumholtz, Nuno Miguel Nunes, Mansuba Rana, Scott Ryall, Javal Sheth, Robert Siddaway, Tejus A Bale, Eric Bouffet, Michael D Cusimano, Sunit Das, Jay Detsky, Peter Dirks, Matthias A Karajannis, Paul Kongkham, Alexandra Giantini-Larsen, Bryan Kincheon Li, Mary Jane Lim-Fat, Andrew L Lin, Warren P Mason, Alexandra Miller, James R Perry, Arjun Sahgal, Sameer Farouk Sait, Derek S Tsang, Gelareh Zadeh, Normand Laperriere, Lananh Nguyen, Andrew Gao, Julia Keith, David G Munoz, Uri Tabori, Cynthia Hawkins
Journal: Nature Cancer (2025)
SAT-027 Therapy of HCV infections among patients of ukrainian origin during the influx of war refugees to Poland
Authors: Robert Flisiak, Dorota Zareèbska-Michaluk, Diana Martonik, Justyna Janocha-Litwin, Hanna Berak, Marek Sitko, Leila Reid, Ryan M. Buchanan. Włodzimierz Mazur, Ewa Janczewska, Beata Lorenc, Jakub Klapaczynski, Łukasz Laurans, Dorota Dybowska, Piekarska Anna, Magdalena Tudrujek-Zdunek, Krystyna Dobrowolska, Anna Parfieniuk-Kowerda
Journal: Journal of Hepatology (2025)
SAT-324 Understanding treatment efficacies of progressive familial intrahepatic cholestasis via a prospective world-wide registry, TreatFIC
Authors: Alida D.E. de Groot, Mark Nomden, Pedro Miranda Afonso, Emmanuel Gonzaleès, Verena Keitel-Anselmino, Ekkehard Sturm, Richard J. Thompson, Henrik Arnell, Björn Fischler, Mara Cananzi, Antal Dezsoèfi, Lorenzo D’Antiga, Angelo Di Giorgio, Tassos Grammatikopoulos, Giuseppe Indolfi, Irena Jankowska, Nathalie Rock, Eyal Shteyer, Georg-Friedrich Vogel, Jian-She Wang, Bettina E. Hansen, Paola Mian, Henkjan J. Verkade
Journal: Journal of Hepatology (2025)
WED-342 Artificial intelligence-driven qFibrosisin alpha-1-antitrypsin deficiency-associated liver disease: correlation with METAVIR stage and other disease specific features
Authors: Vandana Gupta, Feng Hong, Talakad G. Lohith, Jen-Chieh Chuang, Jie Cheng, Ran Ye, Natasha Darras, Alexander J. Prokopienko, Susana Gonzalez, Paresh Thakker, Nirav K. Desai, Thomas Schluep, James Hamilton, Kutbuddin Akbary, Dean Tai, Pavel Strnad, Virginia C. Clark, Romil Saxena, Cynthia Behling, Kay Washington
Journal: Journal of Hepatology (2025)
WED-029 Patient-reported outcomes measuring an individual’s overall self- rated health after long-term treatment with bulevirtide 2 mg for chronic hepatitis delta in the phase 3 MYR301 trial
Authors: Maria Buti, Heiner Wedemeyer, Soo Aleman, Vladimir Chulanov, Viacheslav Morozov, Olga Sagalova, Tatiana Stepanova, Robert G. Gish, Andrew Lloyd, Dmitry Manuilov, Audrey Lau, Anu Osinusi, Marvin Rock, Chong Kim, Shubhram Pandey, Barinder Singh, Pietro Lampertico
Journal: Journal of Hepatology (2025)
SAT-384 Antinuclear antibodies target unknown autoantigens in porto- sinusoidal vascular disorder without portal hypertension
Authors: Nicola Pugliese, Antonio Tonutti, Natasa Isailovic, Davide Polverini, Angela Ceribelli, Stella de Nicola, Maria de Santis, Carlo Selmi, Alessio Aghemo
Journal: Journal of Hepatology (2025)
SAT-397-YI Long-term clinical outcomes, efficacy, and safety of transjugular intrahepatic portosystemic shunt in Budd Chiari syndrome
Authors: Shekhar Swaroop, Sagnik Biswas, Shubham Mehta, Arnav Aggarwal, Samagra Agarwal, Baibaswata Nayak, Shivanand Gamangatti, Shalimar Shalimar
Journal: Journal of Hepatology (2025)
SAT-400 Estimating the diagnosis rate of alpha-1 antitrypsin deficiency: insights from population-based cohorts in the USA
Authors: Grahame Evans, Xinruo Zhang, Jennifer Below, Kari E. North, May Hagiwara, Chitra Karki, Tami Nussbaum, Suna Park, Kaili Ren, Virginia C. Clark
Journal: Journal of Hepatology (2025)
SAT-462 First-in-human single and multiple ascending dose study of AZD2389, a potent inhibitor of fibroblast activation protein, in healthy participants to evaluate safety, tolerability, pharmacokinetics and target engagement
Authors: Vian Azzu, Samuel Daniels, Mathias Liljeblad, Tiffany Schärer, Mohammad Niazi, Amparo Casanova, David Janzén, Deepa Arya, Victoria Parker, Karin Björhall, Anna Bogstedt, Tasso Miliotis, Pavlo Garkaviy, Jelena Saillard, Mahssa Karimi, Armando Flor
Journal: Journal of Hepatology (2025)
SAT-328 Comparison of disease presentation features, morbidity and mortality rates of screening or index cases in patients with Wilson’s disease
Authors: Kadir Demir, Aslı Çifcibaşı Örmeci, Bilger Çavus, Sezen Genç Uluçeçen, Zülal İstemihan, Kanan Nuriyev, Aynure Rustamzade, Filiz Akyuz, Fatih Beşışık, Sabahattin Kaymakogèlu
Journal: Journal of Hepatology (2025)
TOP-330 Prevalence and prognostic impact of sarcopenia in porto- sinusoidal vascular disorder
Authors: José Ferrusquía-Acosta, Katharina Lampichler, Maxime Ronot, Anna Darnell, Damián Gil-Bello, Diego San Martin, Mireia Gamundi, Lambert Kernanet, Chengjian Wu, Luo Xuefeng, Fátima Torres Gómez, Pablo Roman-García, Andreea Fodor, Bogdan Procopet, Stefania Gioia, Silvia Nardelli, Federico Ravaioli, Elton Dajti, Cyprien Gayat, Laure Elkrief, Mathilde Wagner, Héloise Giudicelli, Arathi Venu, Arun Valsan, Esther Benitez-García, Carlos González-Alayón, Ainhoa Sánchez-Lorenzo, Daniel Selva-Talón, Dario Saltini, Filippo Schepis, Giovanni Vitale, Laura Turco, Ozgur Koc, Marta García-Calonge, Elba Llop Herrera, Nicola Pugliese, Thomas Reiberger, Virginia Hernández-Gea, Juan Carlos García-Pagán, Bernhard Scheiner, Pierre-Emmanuel Rautou, Lorenz Balcar, Anna Baiges
Journal: Journal of Hepatology (2025)
FRI-419-YI Therapeutic potential of targeting processing-bodies in metabolic dysfunction-associated steatohepatitis and hepatocellular carcinoma
Authors: Noémie Gellée, Noémie Legrand, Mickaël Jouve, Fabrice Bray, Pierre-Jean Devaux, Viviane Gnemmi, Laurent Dubuquoy, Cyril Sobolewski
Journal: Journal of Hepatology (2025)
WED-418-YI One-year changes in ALT and LSM, not in CAP, predict long-term liver outcomes in patients with metabolic dysfunction-associated steatotic liver disease
Authors: Grazia Pennisi, Giuseppe Infantino, Gabriele Di Maria, Emmanuel Tsochatzis, Elisabetta Bugianesi, Masato Yoneda, Ming-Hua Zheng, Hannes Hagström, Jerome Boursier, José Luis Calleja Panero, George Boon Bee Goh, Chan Wah Kheong, Rocio Gallego-Durán, Arun J Sanyal, Victor de Lédinghen, Philip Newsome, Jiangao Fan, Laurent Castera, Michelle Lai, Céline Fournier-Poizat, Grace Lai-Hung Wong, Angelo Armandi, Atsushi Nakajima, Wen-Yue Liu, Ying Shang, Marc de Saint-Loup, Elba Llop Herrera, Kevin Kim Jun Teh, Carmen Lara-Romero, Amon Asgharpour, Sara Mahgoub, Sau-Wai Mandy Chan, Clémence M Canivet, Manuel Romero-Gómez, Huapeng Lin, Seung Up Kim, Terry Cheuk-Fung Yip, Adele Tulone, Jimmy Lai, Boyu Yang, Abraham Aregay Desta, Giacinta Ciancimino, Marco Enea, Calogero Camma, Vincent Wai-Sun Wong, Salvatore Petta
Journal: Journal of Hepatology (2025)
WED-454-YI Decoding fibrosis: transcriptomic and clinical insights via AIderived collagen clusters in MASLD
Authors: Marta Wojciechowska, Mira Thing, Yang Hu, Gianluca Mazzoni, Lea Mørch Harder, Mikkel Werge, Vivek Das, Mogens Vyberg, Robert D. Goldin, Reza Serizawa, Elisabeth Galsgaard, Dan Woodcock, Henning Hvid, Dominik Pfister, Vanessa Jurtz, Lise Lotte Gluud, Jens Rittscher
Journal: Journal of Hepatology (2025)
TOP-015 Emergency department opt out testing for HBV and HCV in London with integrated linkage to care: an effective initiative to diagnose hepatitis or work in progress?
Authors: Rachel Hill-Tout, Graham R Foster, Ashley Brown, Douglas Macdonald, Dan Forton, Patrick Kennedy, Matthew Foxton, Paul Trembling, Upkar Gill, Meera Kirby, Thendral Mangala, Gabriel Willis, Laura Blackmore, Julian Surey, Stuart Smith, Pamela Healy, Supa Chantschool, Joy Ko, Emma Susannah Young, Oliver Mizzi, Laura Hunter, Kevin Fenton, Mark Gillyon-Powell, Ian Jackson, Stephen Hindle, Georgia Threadgold, Beatrice Emmanouil, Peter Sandwith, Kosh Agarwal
Journal: Journal of Hepatology (2025)
WED-438 Systematic review of care pathways for metabolic dysfunctionassociated steatotic liver disease (MASLD)
Authors: Kirsi van Eekhout, Niels Broekman, Vivian de Jong, Maurice Michel, Diederick Grobbee, Douglas Maya-Miles, Manuel Romero-Gómez, Jean Muris, Juan Mendive, Oscar Franco, Jörn M. Schattenberg, Céline Fournier-Poizat, Manuel Castro Cabezas, Maarten Tushuizen, A.G. (Onno) Holleboom
Journal: Journal of Hepatology (2025)
SAT-383-YI Non-invasive stratification of portal hypertension in patients with BCR::ABL1-negative myeloproliferative neoplasms
Authors: Can Hopp, Lina Degenfeld-Schonburg, Lorenz Balcar, Georg Kramer, Irene Graf, Lucie Simonis, Christian Sillaber, Heinz Gisslinger, Tobias Meischl, Albert Friedrich Stättermayer, Mattias Mandorfer, Thomas Reiberger, Michael Trauner, Bernhard Scheiner, Maria-Theresa Krauth, Georg Semmler
Journal: Journal of Hepatology (2025)
THU-023 Health behaviors significantly modify the sex-specific alcohol-attributable liver-related mortality in the United States. A population-based study
Authors: Eduardo Vilar Gomez, Lauren Nephew, Samer Gawrieh, Raj Vuppalanchi, Francis Pike, Carla Kettler, Tu Wanzhu, Niharika Samala, Suthat Liangpunsakul, Naga Chalasani
Journal: Journal of Hepatology (2025)
THU-031 MASLD impacts quality of life and work productivity
Authors: Leen Heyens, Christophe van Steenkiste, Yves Kockaerts, Ine Lowyck, Kirsten Stinkens, Heddy van Leeuwen-Wintjens, Liesbet Vernijns, Jacques Germeaux, Toon Meyers, Jan Gyselaers, Sjors Pietermans, Ruth Bollen, Anneleen Robaeys, Roy Remmen, Jean Muris, Marjolijn Uitterhoeve-Prins, Michelle Bremers, Loes van Bokhoven, Struyve Mathieu, Sven Francque, Ger Koek, Geert Robaeys
Journal: Journal of Hepatology (2025)
FRI-005 Metabolic dysfunction-associated steatotic liver disease as the leading cause of hepatocellular carcinoma in mexican cirrhotic patients: a perspective consistent with trends observed in europe
Authors: Nahum Méndez-Sánchez, Mariana Ramírez-Mejía, Carlos Cortez-Hernández, Elianee Tovar-Bojorquez, Raul Contreras, Juan Monsiváis Morales, Jacqueline Cordova-Gallardo, Mauricio Castillo, Nubia Guzmán-Rodriguez, Maria Sarai González-Huezo, Adrián Sández Araiza, Eira Cerda Reyes, Beatriz Barranco-Fragoso, Ana Cano-Contreras, José Remes-Troche, Fatima Higuera-de-la-Tijera, José Luis Pérez-Hernández, Norberto Chávez-Tapia, Francisco Valentin-Cortez, Iaarah Montalvo, Ruben R Lozano-Salazar, Montserrat Sabanes, Itziar Borbolla-Schega, Heriberto Rodriguez-Hernández
Journal: Journal of Hepatology (2025)
FRI-022 Ultra-processed foods significantly increase liver and metabolic injury among younger adults, lessons from the liver screening program SIRIUS
Authors: Tomas Koller, Daniel Jan Havaj, Svetlana Adamcova Selcanova, Daniela Žilincèanová, Natalia Kubanek, Karolina Sulejova, Martin Janicèko, Sylvia Dražilová, Maria Szantova, Marek Rac, Lubomir Skladany
Journal: Journal of Hepatology (2025)
FRI-425 Thrombospondin-2 reflects improved metabolism and attenuated liver fibrogenesis in severely obese patients undergoing an intensive weight-loss therapy
Authors: Rambabu Surabattula, Nathalie Rohmann, Julia Koppenhagen, Alexia Beckmann, Perdita Wietzke-Braun, Tim Hollstein, Sudha Rani Myneni, Katharina Hartmann, Lucy Kruse, Kristina Schlicht, Corinna Geisler, Kathrin Türk, Dominik Schulte, Matthias Laudes, Detlef Schuppan
Journal: Journal of Hepatology (2025)
WED-464-YI Gaps in screening and management of metabolic dysfunctionassociated steatotic liver disease: a retrospective audit of patients at cardiometabolic risk in a secondary care setting
Authors: Monica Cucco, Renata de Maria, Chiara Pavanello, Lucia Cesarini, Giuliana Mombelli, Antonia Alberti, Federico Bertuzzi, Luca Saverio Belli, Laura Calabresi
Journal: Journal of Hepatology (2025)
THU-011 Incidence-based mortality trends of primary liver cancer (hepatocellular carcinoma and intrahepatic cholangiocarcinoma) in Scotland between 2000 and 2021
Authors: Berkay Yanik, Karin Oien, Greig Stanners, Callum Rintoul, Anya Adair, Euan Dickson, David Morrison
Journal: Journal of Hepatology (2025)
SAT-446 Survodutide activates cAMP signaling and reduces steatosis and fibrosis through its glucagon component in human liver spheroids
Authors: Philip Vonschallen, Lisa Hoelting, Angelina Breen, Mafalda Pereira, Radina Kostadinova, Joel Zvick, Jesus Glaus, Robert Augustin, Heike Neubauer, Francisco Verdeguer, Thomas Klein
Journal: Journal of Hepatology (2025)