tbuckley/cabot-search huggingface dataset:
CLINICAL EXPERIENCES WITH LONG-ACTING INSULIN IN AMBULATORY DIABETIC PATIENTS
Authors: H. Clare Shepardson, Richard Dufficy Friedlander
Journal: Annals of Internal Medicine (1938)

Article1 December 1938CLINICAL EXPERIENCES WITH LONG-ACTING INSULIN IN AMBULATORY DIABETIC PATIENTSH. CLARE SHEPARDSON, M.D., F.A.C.P., RICHARD DUFFICY FRIEDLANDER, M.D.H. CLARE SHEPARDSON, M.D., F.A.C.P.Search for more papers by this author, RICHARD DUFFICY FRIEDLANDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-6-830 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the publication of Hagedorn's article1 on protamine insulinate in January 1936, followed by the substitution of protamine zinc insulin for protamine insulinate as the result of the work of Scott and Fisher2 and the introduction of a new crystalline insulin by Sahyun of Detroit, medical periodicals have been flooded with reports concerning the treatment of diabetes mellitus with these new long-acting insulins.To review this literature would be superfluous indeed, since it has been adequately summarized in numerous previous articles. The reader interested in a comprehensive survey of the literature on this subject is referred to the papers of...Bibliography1. HAGEDORNJENSENKRARUPWODSTRUP HCBNNBI: Protamine insulinate, Jr. Am. Med. Assoc., 1936, cvi, 177-180. CrossrefGoogle Scholar2. SCOTTFISHER DAAM: Studies on insulin with protamine, Jr. Pharm. and Exper. Therap., 1936, lviii, 78-92. Google Scholar3. JOSLIN EP: Protamine insulin, Jr. Am. Med. Assoc., 1937, cix, 497-503. CrossrefGoogle Scholar4. WILDER RM: Clinical investigations of insulins with prolonged activity, ANN. INT. MED., 1937, xi, 13-38. Google Scholar5. RICKETTS HT: Problems connected with the use of protamine-zinc-insulin, ANN. INT. MED., 1937, xi, 777-790. Google Scholar6. ALTSHULER SS: The clinical use of crystalline insulin, ANN. INT. MED., 1937, xi, 901-906. Google Scholar7. ALTSHULERLEISER SSR: The effect of zinc content upon the action of insulin, Am. Jr. Med. Sci., 1938, cxcv, 234-239. CrossrefGoogle Scholar8. ALLEN FM: Protamine insulin and diabetes treatment, Medical Times, 1937, lxv, 608-610. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Delivered before the American College of Physicians, New York City, April 6, 1938.From the Division of Medicine, University of California Medical School, San Francisco, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1938Volume 12, Issue 6Page: 830-837KeywordsDiabetes mellitusInsulinProtaminesZinc ePublished: 1 December 2008 Issue Published: 1 December 1938 PDF downloadLoading ...
Mass Screening for Colorectal Cancer in Hungary
Authors: P Preisich, S Siba, E Szakátsy
Journal: Journal of the Royal Society of Medicine (1987)

Haemoccult screening for colorectal tumours was carried out in Hungary in small cities and villages around Budapest. Haemoccult slides were supplied to 17,662 individuals over 40 years of age, and 15,431 (87%) were returned. Of these, 346 (2.2%) were positive and 18 colorectal carcinomas were detected. Additionally, 24 patients with one or more polyps greater than 1 cm diameter were found. Of the screened cases of cancer 39% were in Dukes' stage A and B, a rate twice as good as when screening was not done. The cost per tumour detected amounted to about three times more than one monthly income, indicating that the costs of screening for colorectal cancer are relatively much higher in Hungary than in Western countries. All expenses were met from state funds.
Long-Term Survival Following Coronary Artery Bypass Grafting
Authors: Joon Bum Kim, Sung-Cheol Yun, Jae Wong Lim, Soo Kyung Hwang, Sung-Ho Jung, Hyun Song, Cheol Hyun Chung, Jae Won Lee, Suk Jung Choo
Journal: Journal of the American College of Cardiology (2014)
Abstract 10399: Impact of Ozone Air Pollution on Ischemic Cerebral and Cardiac Events in Dijon, France.
Authors: Yannick Bejot, Jean Bernard Henrotin, Guy Victor Osseby, Marianne Zeller, Yves Cottin, Maurice Giroud
Journal: Circulation (2010)

Background:  There is strong evidence that short-term exposure to ozone (O 3 ) is associated with respiratory disease and death, but the effects of short-term exposure to ozone on ischemic heart and cerebrovascular disease have not been clearly established.   Methods:  Daily levels of urban O 3  pollution, the incidence of first-ever, recurrent, fatal and non-fatal ischemic cerebro-vascular events (ICVE) and myocardial infarction (MI) were compared using a bi-directional case-crossover design analysis. We analysed 1 574 ICVE and 913 MI that occurred in Dijon, France from 2001 to 2007. Sulphur dioxide (SO 2 ), nitrogen dioxide (NO 2 ), carbon monoxide (CO), particulate matter with an aerodiameter of ≤ 10μg/m3 (PM10) were used to create bi-pollutant models. Using the adjusted Odd Ratios (OR), the effects of O 3  exposure were calculated for every 10 μg/m3 increase in pollutants in multivariate logistic models adjusted for all possible confounders.   Results:  We found a statistically significant association between even low-levels of O 3  and recurrent ICVE with a 3-day lag (OR=1.115; 95%CI: 1.027–1.209). The association was marginally significant for recurrent MI with 1-day lag (OR=1.147; 95 % CI: 0.999–1.318). For incident events, we detected no significant association. In stratified analysis by vascular risk factors, we observed for ICVE an association with each vascular risk factor (OR=1.523; 95 % CI: 1.149–2.018) while for MI, an association with O 3  was found when hypercholesterolemia was present (OR=1.111; 95 %: 1.020–1.211). Moreover, we noted an increase in the strength of association with an increasing number of combined factors.   Conclusions:  From this population-based study, recurrent ICVE and MI could be triggered by short-term exposure to even low levels of O 3 , especially among subjects with severe vascular risk factors. As a result, preventive strategies could be designed for such subjects.
Abstract 8918: Diagnostic Criteria for Ultrasound Diagnosis of Internal Carotid Artery Stenosis Vary Widely Among Accredited Vascular Laboratories. A Survey from the Intersocietal Commission for the Accreditation of Vascular Laboratories (ICAVL)
Authors: Heather L Gornik, Marge Hutchisson, Mariam Khan, James F Benenati, Michael R Jaff, Sandra Katanick, Laurence Needleman
Journal: Circulation (2011)

Background: Carotid duplex ultrasound (DUS) is widely used for diagnosis of internal carotid artery (ICA) stenosis and therapeutic decisions are often on the basis of DUS findings. There are no universal standard DUS criteria to grade the severity of ICA stenosis. A 2003 publication from the Society for Radiologists in Ultrasound (SRU) provided consensus criteria for grading ICA stenosis, but their integration into clinical practice is unknown. Methods: Random sample of 10% of vascular laboratories accredited in extracranial carotid testing. Data were abstracted from the ICAVL database, including most recent accreditation application. A single reviewer (HLG) compared laboratory diagnostic criteria to published references. Results: 152 vascular laboratories were sampled, 57.2% of which were outpatient based. Mean annual carotid volume 1,330 + 124.1 studies (range 100-9,858). There were 17 diagnostic criteria in use among 117 labs with the remaining facilities utilizing locally developed (6 labs) or unreferenced or hybrid criteria (29 labs). Mean number of categories of ICA stenosis was 5.80 + .084 (range 3-12). Cut-points for the mildest disease stratum ranged from 0 to 0-60% with normal or 0% most commonly reported (67.1% of labs). The cut-point for most severe (non-occlusive) stenosis ranged from 70 to 91% with 80% most commonly reported (64.5% of labs). SRU consensus-based criteria were used in only 27.0% of laboratories, although there was a statistically significant increase in SRU utilization among labs accredited after versus before 2005 (50.0% vs. 18.8%, P &lt;0.001). Despite divergent diagnostic criteria and severity cut-points, self-reported accuracy of DUS for diagnosis of ICA stenosis from correlation studies was high (mean 85.8 + 0.65%). Conclusion: Diagnostic criteria and cut-points for grading severity of ICA stenosis using DUS vary widely in accredited vascular laboratories. Despite this, diagnostic accuracy is acceptable. Uptake of SRU consensus criteria has been limited, but is more common among recently accredited facilities. Health care providers must be aware of the lab-to-lab variation in reporting of ICA stenosis while further efforts to achieve consensus reporting are considered by professional societies.
Abstract 17133: Cardiac Steatosis Detected in Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy and Aortic Stenosis
Authors: Joseph J Suttie, Sairia Dass, Sacha Bull, Cameron Holloway, Rajarshi Banerjee, Pete Cox, Alex Pitcher, Belen Rial Franco, Jane Francis, Jurgen Schneider, Matthew Robson, Hugh Watkins, Saul Myerson, Stefan Neubauer
Journal: Circulation (2011)

BACKGROUND The failing heart is characterised by impaired myocardial energetics and a compensatory shift from fatty acid to glucose metabolism. Cardiac steatosis has been implicated in ventricular contractile dysfunction, hypertrophy, inflammation and arrhythmias.Therefore we assessed cardiac steatosis using 1H magnetic resonance spectroscopy in hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM, EF35 mmHg, LVEF&gt;45%). METHODS 75 prospectively enrolled subjects (15 DCM, LVEF34±15%; 17 HCM, LV mass 165±42g; 14 AS, gradient 44±2 mmHg and 29 normal volunteers) were scanned at 3T.1H magnetic resonance spectroscopy (MRS) was used to quantify myocardial lipid/water content(%) and 31P MRS to measure the phosphocreatine/adenosine triphosphate (PCr/ATP) ratio in the same region of the mid-ventricular septum. LVEF was assessed using cine imaging and tagging was used to assess global circumferential strain (% deformation normal -19±2; reduced contraction between -16 and 0%). RESULTS All subjects were well matched between cohorts for BMI, fasting glucose and total cholesterol (26±4 kg/m2, 5.0±0.6mmol/l, 5.1±1.2 mmol/l, p&lt;0.05). Cardiac lipid content was elevated in all patientcohorts compared with normal volunteers (HCM 0.7±0.4; DCM 0.7±0.3; AS 0.7±0.6 vs normals 0.33±0.2% lipid/water, p&lt;0.01 for all). PCr/ATP ratios were also impaired in all patientgroups (HCM 1.6±0.2; DCM 1.7±0.2; AS 1.7±0.2 vs normals 2.1±0.2, p&lt;0.01 for all).Peak systolic circumferential strain was impaired in HCM (-16±2%, p&lt;0.01) and DCM (-14±3%, p&lt;0.01) compared to normals (-19±2%) but unchanged in AS (-18±2%). CONCLUSION Cardiac steatosis occurs in HCM and DCM in the presence of impaired energetics and abnormal contractile function andin patients with AS in the presence of preserved global contractile function. This suggests a potential role for cardiac steatosis as a novel biomarker and mechanism inboth early and advanced non-ischemic cardiac disease.
Management of primary intraocular lymphoma (PIOL): Results from the prospective German PIOL registry (PIOL-R).
Authors: Kristoph Jahnke, Uwe Pleyer, Martina Herwig, Rainer Guthoff, Matthias Lueke, Tobias Meyer-ter-Vehn, Gregor Willerding, Antonia Joussen, Michael Boehm, Arnd Heiligenhaus, Christina Nolte, Karin Jordan, Friederike Mackensen, Eckhard Thiel, Agnieszka Korfel
Journal: Journal of Clinical Oncology (2014)

2056 Background: The optimal management of primary intraocular lymphoma (PIOL) is yet to be defined. We report on clinical characteristics, treatment and outcome of newly diagnosed, immunocompetent PIOL patients enrolled in the prospective German PIOL registry (PIOL-R). Methods: Patient data in this prospective, non-interventional multicenter study were compiled by standardized questionnaires sent to Ophthalmology and Hematology/Oncology centers in Germany. Results: Twenty-seven patients (17 female, median age 67 years, median Karnofsky performance status 90%) were included between August 2008 and December 2013. Median time from onset of symptoms to PIOL diagnosis was 5 (range, 1-36) months. Diffuse large B-cell histology was found in all patients. First-line treatment included high-dose methotrexate (MTX)- or ifosfamide-based systemic chemotherapy with or without rituximab in 21 (including high-dose chemotherapy [HDCT] with autologous stem cell transplantation [ASCT] in 4), intraocular (i.o.) chemotherapy with MTX (n=1) and/or rituximab (n=10) in 11, ocular radiation in 2, and vitrectomy only in one patient(s). Two patients received prophylactic intrathecal treatment with MTX but none had whole-brain radiotherapy (RT). The PIOL remission rate was 100% with complete remission in 19/23 evaluable patients and partial remission in 4 patients. Median progression-free survival of patients without prior brain involvement (n=23) was 21 (95% CI, 1.2-39.9) months. Overall survival has not yet been reached. Relapses were located in the brain (n=9), eye (n=3), eye/brain (n=3) and eye/meninges (n=1) and were treated with systemic chemotherapy in 12 (including HDCT with ASCT in 3), systemic and i.o. chemotherapy in one, whole brain/spine RT in 2 and best supportive care in one patient(s). Conclusions: Although the awareness of PIOL and diagnostic possibilities have improved, time from symptom presentation to diagnosis seems to remain at previously reported levels. There appears to be a shift from local ocular treatments and RT to systemic therapy as compared to anecdotal data with promising response and survival rates. However, relapse rates remain high with the brain frequently being involved.
CONSTITUTIONAL FACTORS IN ARTHRITIS WITH SPECIAL REFERENCE TO INCIDENCE AND RÔLE OF ALLERGIC DISEASES
Authors: Robert T. Pottenger
Journal: Annals of Internal Medicine (1938)

Article1 September 1938CONSTITUTIONAL FACTORS IN ARTHRITIS WITH SPECIAL REFERENCE TO INCIDENCE AND RÔLE OF ALLERGIC DISEASESROBERT T. POTTENGER, M.D.ROBERT T. POTTENGER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-3-323 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChronic arthritis of the atrophic and hypertrophic types is the most common chronic illness and ranks first among the causes of disability. The high incidence of this disease is indicated by a survey in Massachusetts where 3.2 per cent of the total population and 30 per cent of the disabled were found to be suffering from rheumatoid disease.1 In spite of its prevalence the medical profession as a whole is discouraged or at least apathetic in its treatment.There is no agreement among students of chronic arthritis as to the basic factors or diathesis predisposing the patient to the disease...References1. BIGELOWLOMBARD GHHL: Cancer and other chronic diseases in Massachusetts, 1933, Houghton, Mifflin Co., Boston. Google Scholar2. PEMBERTON R: Arthritis and rheumatoid conditions, their nature and treatment, 1935, Lea and Febiger, Philadelphia, pg. 48-49. Google Scholar3. Ibid., pages 234, 235, 236. Google Scholar4. VAUGHANPIPES WTDM: Is there a correlation between food dislikes and food allergy? Jr. Allergy, 1937, viii, 257-260. CrossrefGoogle Scholar5. RATNER B: Does heredity play a rôle in the pathogenesis of allergy? Jr. Allergy, 1937, viii, 273. Google Scholar6. ROWE AH: Food allergy, 1931, Lea and Febiger, Philadelphia, pg. 19. Google Scholar7. Ibid., page 271. Google Scholar8. WOOTTON WT: The rô;le of allergy in arthritis, Jr. Arkansas Med. Soc., 1936, xxxii, 119-122. Google Scholar9. BROWN GT: Allergic phases of arthritis, Jr. Lab. and Clin. Med., 1934-35, xx, 247-249. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pasadena, California*Received for publication September 21, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRheumatoid arthritis, food, and allergyA Psychosomatic Approach to Rheumatoid Arthritis: A Clinical Study of 100 Female PatientsGenetic factors in diseases of connective tissueFamilial occurrence of the rheumatoid factorThe Occurrence of Rheumatoid Arthritis in TwinsDie GichtAetiology and pathogenesis of rheumatoid arthritisTHE INHERITANCE OF SPONDYLITIS RHIZOMELIQUE (ANKYLOSING SPONDYLITIS) IN THE K. FAMILY*HERMAN H. RIECKER, M.D., F.A.C.P., JAMES V. NEEL, Ph.D., M.D., AVERY TEST, Ph.D.Psychosomatic medicineDie GichtPalindromic rheumatism among allergic personsAllergy in the Domestic Animals 1 September 1938Volume 12, Issue 3Page: 323-333KeywordsAllergic diseasesArthritisDisabilities ePublished: 1 December 2008 Issue Published: 1 September 1938 PDF downloadLoading ...
Thrombosis and Drug-Eluting Stents
Authors: David R. Holmes, Dean J. Kereiakes, Warren K. Laskey, Antonio Colombo, Stephen G. Ellis, Timothy D. Henry, Jeffrey J. Popma, Patrick W.J.C. Serruys, Takeshi Kimura, David O. Williams, Stephan Windecker, Mitchell W. Krucoff
Journal: Journal of the American College of Cardiology (2007)
Per-rectal diclofenac decreases the risk of post-ERCP pancreatitis: What about intramuscular diclofenac?
Authors: Ulku Saritas, Yucel Ustundag
Journal: Endoscopy (2015)

We read with interest the article by Park et al. [1] about the effect of intramuscular diclofenac for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). In this prospective trial, the authors found that PEP developed in 11.8 % (20/170) of the placebo group and in 12.7 % (22/173) of the intramuscular diclofenac group. The difference was not significant, and the authors concluded that prophylactic intramuscular diclofenac does not have any beneficial preventive effect on PEP.
TULAREMIA; A PATHOLOGIC STUDY OF THE LESIONS IN A CASE TREATED WITH SPECIFIC ANTISERUM, THE PATIENT DYING SUDDENLY FROM INTERCURRENT CORONARY OCCLUSION
Authors: Karl V. Kitzmiller
Journal: Annals of Internal Medicine (1939)

Case Reports1 February 1939TULAREMIA; A PATHOLOGIC STUDY OF THE LESIONS IN A CASE TREATED WITH SPECIFIC ANTISERUM, THE PATIENT DYING SUDDENLY FROM INTERCURRENT CORONARY OCCLUSIONKARL V. KITZMILLER, M.D., F.A.C.P.KARL V. KITZMILLER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-8-1375 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe increasing prevalence in the use ofPasteurella tularensisantiserum, which recently has become commercially available, in the treatment of tularemia, makes the report of a fatal case in which the antiserum was used of special interest at this time. Particularly so, when the fatality is sudden and unexpected, following the antiserum treatment by only a few days. Foshay has stated that in his experience in the specific treatment of these cases he knows of none, with the exception of the advanced, overwhelming infections, in which some associated lesion usually involving the circulatory system has not been responsible for the...* FOSHAYMAYER : Viability of Bacterium tularense in human tissues, Jr. Am. Med. Assoc., 1936, cvi, 2141. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cincinnati, Ohio*Received for publication February 12, 1938.From the Pathologic Laboratory, Deaconess Hospital, Cincinnati, Ohio.†I am indebted to Dr. Harry Box for permission to record these findings. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA comparative study of the treatment of tularemia with immune serum, hyperimmune serum and streptomycin 1 February 1939Volume 12, Issue 8Page: 1375-1381KeywordsLesionsResearch laboratoriesTularemia ePublished: 1 December 2008 Issue Published: 1 February 1939 PDF downloadLoading ...
P0321 : Increased anti-tumor effect of vitamin D after CYP24A1 inhibition on HCC cell lines
Authors: H.N.A. Jozilan, P. Horvath, J.P. Kosa, P. Lakatos, D. Nemeth, J. Wölfling, D. Kovacs, B. Bodnar, P. Matyus, E. Horvath, I. Kovalszky, F. Szalay
Journal: Journal of Hepatology (2015)
Abstract #4439: Differential allelic expression of BRCA1 and BRCA2 as a breast cancer susceptibility factor
Authors: Freek Blanken, Paola van der Bent, Cees Cornelisse, Maaike Vreeswijk, Peter Devilee
Journal: Cancer Research (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

The genomes of almost all breast tumors are characterized by many chromosomal changes, including whole chromosome aneuploidy, complex rearrangements, loss of heterozygosity (LOH), and numerous segmental amplifications and deletions. Knudson\#8217;s two-hit model has been a dominant concept for explaining LOH or allelic imbalance, predicting the presence of a recessive mutation in a tumor suppressor gene (TSG). However, few TSGs have been identified by studying LOH in breast cancer. Our hypothesis is that constitutional differential allelic expression (DAE) of certain genes could be a major determinant in tumor development when a particular allelic imbalance pattern at the gene locus is established in the soma. If our hypothesis is correct, we expect to find genes for which, for example, the high-expressed allele is consistently lost in the tumor. In familial breast tumors associated with germline mutations in the BRCA1 or BRCA2 gene, the most common mechanism of inactivation in the tumor is complete loss of the wild-type allele. Although LOH of either of these loci occurs in about half of the sporadic breast cancer cases, somatically acquired mutations in these genes are uncommon. In these cases, allelic expression differences might contribute to tumorigenesis. We measured DAE of BRCA1 and BRCA2 using exonic SNPs in RNA isolated from primary fibroblast cultures of 80 breast cancer patients by pyrosequencing. DAE was observed in 8 out of 36 patients informative for BRCA1 and 5 out of 34 patients informative for BRCA2. So far, eight tumors have been analyzed for LOH using DNA from flow-sorted tumor cells. One patient showed DAE of BRCA1 with loss of the high expressed allele in the corresponding tumor. Analysis of BRCA2 showed DAE with loss of the low expressed allele in one patient. However, this set was too small to correlate somatic DAE with LOH.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 4439.
Redefining Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—Reply
Authors: Ellen Wright Clayton
Journal: JAMA (2015)

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