tbuckley/cabot-search huggingface dataset:
Abstract 16725: Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis and Small Aortic Annulus: Propensity-Matched Comparison to Standard Aortic Valve Replacement
Authors: Eric Dumont, Daniel Doyle, Rodrigo Bagur, Robert DeLaRochelliere, Dimitri Kalavrouziotis, Philipppe Pibarot, Josep Rodes-Cabau
Journal: Circulation (2011)

Background: Few data exist on the results of transcatheter aortic valve implantation(TAVI) in patients with a small aortic annulus(AA) compared to standard aortic valve replacement(SAVR). We sought to examine valve hemodynamics and clinical outcomes of patients with a small AA who underwent TAVI versus SAVR. Methods: Between 2007 and 2011, 46 patients (mean age 79.1±9.4 years) with severe aortic stenosis and an AA diameter &lt;19.5 mm (mean 18.3±0.85 mm) underwent TAVI with a 23-mm Edwards SAPIEN bioprosthesis. These patients were compared to 217 propensity-matched patients who underwent SAVR with a 19-mm valve (78% bioprosthesis). Echocardiographic parameters and clinical outcomes were assessed prior to discharge and at follow-up. Results: There was a greater incidence of postoperative atrial fibrillation (34.6% vs 15.2%, p=0.02), acute kidney injury (12.4% vs 8.7%, p=0.05), and blood product transfusion (83% vs 46%, p&lt;0.001) in the SAVR group compared to the TAVI group. In-hospital mortality was 2.2% in the TAVI group and 6.5% in the SAVR group (p=0.06). One-year survival rate was similar between groups (TAVI 91.3% vs SAVR 87.1%, p=0.20). At hospital discharge, mean transaortic gradients were greater in the SAVR group (18.3 ± 7.2 vs 14.9 ± 9.3 mmHg, p=0.006). Mean indexed effective orifice area (IEOA) was lower in the SAVR group (0.66 ± 0.16 vs 0.84 ± 0.2 cm2/m2, p&lt;0.001), and severe prosthesis-patient mismatch (IEOA &lt; 0.65 cm2/m2) occurred more frequently in the SAVR group (53.3%) than in the TAVI group (9.3%) (p&lt;0.001). Aortic regurgitation(AR) occurred in 72% of the patients in the TAVI group (trivial or mild: 70%, moderate: 2%) compared to 28% of the patients in the SAVR group (trivial or mild in all cases), p&lt;0.001. Echocardiographic results remained unchanged at 1-year follow-up. Conclusion: In patients with severe AS and a small AA, TAVI is associated with lower postoperative morbidity and better valve hemodynamics but a higher incidence of trivial/mild residual AR as compared to SAVR. These results suggest that TAVI is a reasonable alternative to SAVR in elderly patients with small AA.
Changes in Myocardial Infarction Guideline Adherence as a Function of Patient Risk
Authors: Apurva A. Motivala, Christopher P. Cannon, Vankeepuram S. Srinivas, David Dai, Adrian F. Hernandez, Eric D. Peterson, Deepak L. Bhatt, Gregg C. Fonarow
Journal: Journal of the American College of Cardiology (2011)
TRADITION AND PROGRESS IN MEDICINE
Authors: W L PALMER
Journal: Annals of Internal Medicine (1957)

Article1 September 1957TRADITION AND PROGRESS IN MEDICINEWALTER L. PALMER, M.D., F.A.C.P.WALTER L. PALMER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-3-383 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is a very real privilege for the members of the American College of Physicians to hold their thirty-eighth annual session in Boston where the traditions of medicine are so strong and where the progress of medicine is evident on every hand. We all join in paying tribute to our distinguished Boston predecessors who so masterfully advanced our knowledge—George Minot, Francis Peabody, our beloved Reginald Fitz and his father before him, James Jackson, Benjamin Waterhouse, Zabdiel Boylston, the several generations of remarkable Warrens, and many others down to the present time. Slowly over three centuries these men of science built... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Presidential Address, The Thirty-Eighth Annual Convocation of the American College of Physicians, Boston, Massachusetts, April 10, 1957.Requests for reprints should be addressed to Walter L. Palmer, M.D., 950 E. 59th Street, Chicago 37, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1957Volume 47, Issue 3Page: 383-388 ePublished: 1 December 2008 Issue Published: 1 September 1957 Copyright & PermissionsCopyright, ©, 1957, by The American College of PhysiciansPDF downloadLoading ...
Myocardial Ischemia and Infarction
Authors: P Townsend, D Jeffic, J Abboud, Y Almanaseer, M Jabaren, J Gardin, R Fares, R Raddino, H Rosman, L Saravolatz, Z Allebban, R Angeles, J Martindale, C Chen-Scaralbelli, T Scaralbelli
Journal: Journal of the American College of Cardiology (2006)
Abstract P20: Chest Compressions Can Cause Atrial and Ventricular Capture, during Both Sinus Rhythm and after Ventricular Fibrillation
Authors: Jose Osorio, Greg P Walcott, Robert P Robichaux, Derek J Dosdall, Nick Garner, Shannon W Stephens, Todd B Brown, Jeffrey D Kerby, Raymond E Ideker
Journal: Circulation (2008)

Background: Ventricular capture (VC) by external mechanical forces has been described with precordial thumps and commotio cordis. The force required to electrically stimulate the heart during chest...
RESPONSE TO SULFAPYRIDINE IN 241 CASES OF PNEUMONIA, WITH ESPECIAL REFERENCE TO LACK OF PROMPT RESPONSE IN SOME CASES
Authors: Sidney Scherlis
Journal: Annals of Internal Medicine (1942)

Article1 April 1942RESPONSE TO SULFAPYRIDINE IN 241 CASES OF PNEUMONIA, WITH ESPECIAL REFERENCE TO LACK OF PROMPT RESPONSE IN SOME CASESSIDNEY SCHERLIS, M.D.SIDNEY SCHERLIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-4-666 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis paper deals with a series of 241 unselected cases of pneumonia treated with sulfapyridine in 1938-1939 and 1939-1940. This group, although not numerically impressive, is reported because the patients were followed closely and studied carefully, and because an analysis of those cases in which sulfapyridine was not promptly effective yields hitherto unemphasized information of value.DISTRIBUTION OF CASESThe cases reviewed total 241, and are consecutive and unselected save for the omission of a few that were admitted moribund and died within less than 24 hours after admission. Of the series, 73 were seen in the winter of 1938-1939,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 8, 1940.From the Medical Service, Sinai Hospital, Baltimore. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1942Volume 16, Issue 4Page: 666-675KeywordsMedical servicesPneumonia ePublished: 1 December 2008 Issue Published: 1 April 1942 PDF downloadLoading ...
Abstract 12418: Over-Expression of Kir2.1 Channel in Embryonic Stem Cells Derived Cardiomyocytes Reduces Their Post-Transplantation Proarrhythmic Risk in Myocardial Infarction
Authors: Song Y Liao, Yuan Liu, Yue L Zhang, Wen S Yue, Mei C Yip, Yau C Chan, Ronald A Li, Hung F Tse
Journal: Circulation (2011)

Background: Cellular replacement strategies using embryonic stem cells derived cardiomycytes (ESC-CMs) have been shown to improve left ventricular (LV) ejection fraction (LVEF) and prevent LV remod...
miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL
Authors: Valeska Berg, Marion Rusch, Nachiket Vartak, Christian Jüngst, Astrid Schauss, Herbert Waldmann, Christian Hedberg, Christian P. Pallasch, Philippe I. H. Bastiaens, Michael Hallek, Clemens-Martin Wendtner, Lukas P. Frenzel
Journal: Blood (2015)
Science and Technology Committee's report on genetics
Authors: P. Harper
Journal: BMJ (1995)

Recommends an official regulatory body and serves notice on insurers For the first time the British parliament has examined the present state and future possibilities of human genetics and has begun to face up to some of the important implications of and difficult decisions arising from this specialty. Previously, it had left the task to charitable bodies such as the Nuffield Council on Bioethics, whose report in December 1993 identified many of the key issues.1 But the report's call for government action had until recently met with little response. Now the all party Science and Technology Committee of the House of Commons has taken up the challenge and has done so thoroughly and firmly.

Human Genetics: the Science and its Consequences has taken a broad remit, covering such topics as basic genome research, its industrial and economic consequences, patenting, and the role of …
Abstract 5478: P2Y <sub>13</sub> ADP-Receptor Regulates Plasma HDL Clearance, Biliary Cholesterol and Bile Acids Secretions In Vivo
Authors: Laurent O Martinez, Aurélie Fabre, Camille Malaval, Xavier Collet, François Tercé, Bertrand Perret, Jean-Marie Boeynaems, Abduelhakem Ben Addi, Bernard Robaye
Journal: Circulation (2008)

Plasma high density lipoprotein (HDL) protects against atherosclerosis, in part through the removal of cholesterol from peripheral tissues and its delivery to the liver for metabolism and bile excretion. Thus understanding of the molecular event implicated in HDL-cholesterol uptake by the liver is critical to the development of therapeutic strategies to enhance HDL catabolism. The scavenger receptor (SR)-BI modulates plasma HDL level and contributes to cholesteryl ester uptake from HDL in mice but a distinct pathway for holo-HDL particle uptake (protein + lipid) has been recently identified in human hepatocytes. This pathway which strictly depends on extracellular ADP level involves different cell surface partners: ADP generated from the activation by apo AI (the main HDL apolipoprotein) of a cell surface F 1 -ATPase, activates the P2Y 13 ADP-receptor and subsequent HDL endocytosis through an unknown low-affinity HDL receptor. To evaluate the physiological relevance of this P2Y 13 -mediated HDL endocytosis pathway in vivo in mice, P2Y 13 receptor was activated by treating C57BL/6 and liver specific SR-BI-KO mice (SR-BI-KO liver ) with the specific agonist (AR-C69931MX, 8nmol/kg, intra-orbital injection). Expression of P2Y 13 protein in liver was also disrupted by siRNA adenovirus (10 9 vp/mice, intra-orbital injection) and in P2Y 13 KO mice. Plasma clearance of 125 I-labeled HDL was rapidly enhanced under AR-C69931MX treatment in SR-BI-KO liver mouse. Conversely, HDL clearance was decreased in P2Y 13 KO mice but no modification was observed in plasma lipids profile versus control mice, suggesting a mechanism of modulation of plasma HDL turnover rather than a simply disruption of HDL uptake. Furthermore, biliary lipids content was decreased under P2Y 13 extinction in mice (bile acids: −60%, cholesterol: −30%), whereas it was dramatically increased under stimulation of P2Y 13 by AR-C69931MX treatment in C57BL/6 mice (bile acids: +85%, cholesterol: +50%,). These results indicate that P2Y 13 has an important role in hepatic HDL metabolism in controlling circulating HDL turnover and biliary lipids elimination, and thus may have an impact on the development of atherosclerosis.
Abstract 15893: The MiR-30 Family is Regulated by Shear Stress and Affects the Expression of Inflammatory Cell-Cell Adhesion Molecules
Authors: Carmen Doebele, Eduard Hergenreider, Reinier Boon, Natalja Reinfeld, Andreas M Zeiher, Stefanie Dimmeler
Journal: Circulation (2011)

Laminar blood flow exerting high shear stress on the endothelium is known to prevent local atherosclerosis formation and reduces apoptosis and inflammatory pathways in endothelial cells (ECs). Micr...
Abstract 4835: Angiotensin-Converting-Enzyme 2 (rhACE2) Potently Attenuates the Negative Hemodynamic Effects of Angiotensin II (ATII) and Improves Post-Myocardial Infarction (MI) Remodeling
Authors: Bernhard Unsoeld, Manfred Schuster, Hans Loibner, Alexander Becker, Tim Seidler, Claudius Jacobshagen, Keiji Kuba, Yumiko Imai, Josef Penninger, Gerd Hasenfuss
Journal: Circulation (2008)

ATII is a potent vasoconstrictor involved in the pathophysiology of several diseases. Antagonizing the Renin-Angiotensin-Aldosterone-System (RAAS) is one of the key principles in the treatment of heart failure. ACE2, a recently discovered homologue of the Angiotensin-Converting-Enzyme (ACE), catalyzes the cleavage of ATII to Angiotensin (1–7) as well as other reactions. rhACE2 has proven to be therapeutic in a model of the Adult Respiratory Distress Syndrome (ARDS). This study has been planned to study the in-vivo hemodynamic effects of rhACE2 as well as its effects on post-MI remodeling. rhACE2 was produced in a mammalian expression system. Pressure-volume catheter measurements were carried out in male C57/Bl6N mice. Post-MI remodeling was studied by echocardiography in female C57/Bl6N mice after LAD-ligation. Bolus infusion of 2mg/kg rhACE2 (n=7) lead to a significant reduction of arterial elastance by 13.2±1.1% (p&lt;0.01) paralleled by a modest drop in maximal systolic blood pressure from 93.4±4.2mmHg to 86.3±5.1mmHg (p&lt;0.01). Stroke volume and cardiac output showed a strong trend (p=0.06 and 0.08 respectively) to increase after rhACE2-treatment. Following ACE2 (n=5) or vehicle infusion (n=8) ATII was infused at constant infusion rates from 0.2μg/kg/min to 40μg/kg/min. ACE2 pretreatment shifted the EC50 for the ATII induced increase in systolic blood pressure by almost one order of magnitude from 1.11μg/kg/min (CI 0.42 to 2.9) to 10.9μg/kg/min (CI 7.2 to 16.7) (p=0.014). Similarly the EC50 values for the ATII mediated decrease in ejection fraction and preload adjusted maximal power as well as the increase of end systolic volume were significantly shifted to higher ATII doses. To study post-MI remodeling mice were treated twice daily with intraperitoneal injections of 1mg/kg rhACE2. Echocardiography was performed 2 weeks following LAD. Mice treated with rhACE2 (n=15) showed a significantly improved fractional shortening (14.3±1.6%) compared to vehicle treated mice (10.3±1.1%, n=12, p=0.049). These data show that rhACE2 is highly potent in reducing the negative effects of ATII in vivo which might translate in improved post-MI remodeling. rhACE2 could become an alternative treatment option for several diseases related to an activated RAAS.
Abstract 13956: Physical Exercise Prior to Femoral Artery Ligation Stimulates Collateral Artery Growth in a Nitric Oxide-Dependent Manner
Authors: Stephan H Schirmer, Lisa Schuh, Michael Bohm, Ulrich Laufs
Journal: Circulation (2011)

Background: Physical exercise is important in cardiovascular prevention and therapy. In arterial stenosis, exercise increases collateral flow by enhancing fluid shear stress. The effects of physica...
Induction of Apoptosis by Pyrrolobenzothiadiazepines (PBTDs) in Cell Lines and in 12 Chronic Myeloid Leukemia Patients at Onset and Imatinib-Resistant.
Authors: Carla Di Stefano, Elisabetta Abruzzese, Gabriella Marfe, Romano Silvestri, Gianfranco Catalano, Malgorzata M. Trawinska, Paola Sinibaldi-Salimei, Sergio Amadori
Journal: Blood (2004)
NEUROSES IN THE COMBAT ZONE
Authors: William J. Bleckwenn
Journal: Annals of Internal Medicine (1945)

Article1 August 1945NEUROSES IN THE COMBAT ZONEWILLIAM J. BLECKWENNWILLIAM J. BLECKWENNSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-2-177 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLittle did any of us believe, four years ago, that our nation, morally decent and peaceloving, could be developed into the greatest military power in the history of mankind! Little did we realize that we could mobilize our manpower and production to provide the necessary material to prosecute this global war. We not only succeeded in preventing enemy invasion of our own shores but helped turn the tide for our beleaguered allies who were facing impending disaster. A few years ago we were a smugly complacent pacifistic democracy, comfortably entrenched in a false feeling of security due to what we... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Regional Meeting of the American College of Physicians, November 4, 1944. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1945Volume 23, Issue 2Page: 177-183KeywordsArmed forcesEmotions ePublished: 1 December 2008 Issue Published: 1 August 1945 PDF downloadLoading ...
A Clinical Study of a Graphic Method of Recording Blood Pressure
Authors: Louis Faugeres Bishop
Journal: Annals of Internal Medicine (1930)

Article1 February 1930A Clinical Study of a Graphic Method of Recording Blood PressureLOUIS FAUGERES BISHOP, M.D., LOUIS FAUGERES BISHOP JR., M.D.LOUIS FAUGERES BISHOP, M.D., LOUIS FAUGERES BISHOP JR., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-8-808 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHales' demonstration in 1733 proved that the movement of the blood carried with it a necessary consequence, that of pressure. This was made known one hundred years after the discovery of the circulation of the blood by Harvey, but another hundred years elapsed before this fact was given serious consideration. In 1828 Poiseuille introduced the mercury manometer of U form by which he was able to study blood pressure within a circumscribed space. Coagulation was retarded by sodium bicarbonate, a method in use today. All this work paved the way to newer discoveries and in 1847 Ludwig made use of...Bibliography1 JANEWAY TC, M.D.: The Clinical Study of Blood Pressure, D. Appleton & Co., 1904. Google Scholar2 BARR DR, M.D., Rochester, N. Y.: Preliminary Note on New Method of Recording Blood Pressure with Presentation of a Model, Anesth. & Analg., Dec., 1927. CrossrefGoogle Scholar3 MORRIS GW, A.B., M.D.: Blood Pressure, Lea & Febiger, 1917. Google Scholar4 AMBLARD LA, M.D.: Determination of Blood Pressure by Graphic Method: The Sphygmometrograph, J. de méd. de Paris, 26, 495, 1927. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York*Presented before the Boston meeting of the American College of Physicians, April 9, 1929. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCardiovascular and respiratory effects from celiac ganglia stimulation in man 1 February 1930Volume 3, Issue 8Page: 808-814KeywordsBicarbonatesBloodBlood pressureSodium Issue Published: 1 February 1930 PDF downloadLoading ...
Abstract 15102: Are T wave Inversions in the Anterior Precordial Leads Benign in African- Americans?
Authors: Clarence M Findley, Ricardo Stein, Marco Perez, Euan Ashley, Victor Froelicher
Journal: Circulation (2012)

Introduction: While it has been proposed that T wave inversions (TWI) in the anterior precordial leads can be a normal finding in the ECGs of Afro-Caribbean athletes, it is uncertain whether this h...
COX-2 as prognostic factor in lung cancer: systematic review of the literature with meta-analysis.
Authors: Céline Mascaux, Benoît Martin, Marianne Paesmans, Thierry Berghmans, Annick Haller, Anne-Pascale Meert, Michelle Dusart, Philippe Lothaire, Jean-Jacques Lafitte, Jean-Paul Sculier
Journal: European Respiratory Journal (2005)
COLD ALLERGY: REPORT OF AN UNUSUAL CASE
Authors: Wallace M. Yater, Edward W. Nicklas
Journal: Annals of Internal Medicine (1941)

Case Reports1 October 1941COLD ALLERGY: REPORT OF AN UNUSUAL CASEWALLACE M. YATER, M.D., F.A.C.P., EDWARD W. NICKLAS, M.D.WALLACE M. YATER, M.D., F.A.C.P.Search for more papers by this author, EDWARD W. NICKLAS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-4-743 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCold allergy has been known since 1866, when Bourden1described urticaria and syncope due apparently to cold. However, in 1872 Blachez2gave the first classical description of urticaria from cold. Since then several other writers have reported cases of this form of allergy. Since 1924 Duke3has written voluminously on this subject, describing various forms of physical allergy, which he found to be not uncommon. He suggested the possibility that a histamine-like substance might be liberated locally and be responsible in some instances. Lewis4later showed the probable existence of such a substance. In 1929 Horton and Brown5reported a...Bibliography1. BOURDEN : Quoted by Horton, Brown and Roth.6 Google Scholar2. BLACHEZ : Quoted by Horton, Brown and Roth.6 Google Scholar3. DUKE WW: Urticaria caused specifically by the action of physical agents, Jr. Am. Med. Assoc., 1924, lxxxiii, 3. CrossrefGoogle Scholar4. LEWIS T: The blood vessels of the human skin, etc., 1927, Shaw and Sons, Ltd., London. Google Scholar5. HORTONBROWN BTGE: Systemic histamin-like reactions in allergy due to cold; report of six cases, Am. Jr. Med. Sci., 1929, clxxii, 191. CrossrefGoogle Scholar6. HORTONBROWNROTH BTGEGM: Hypersensitiveness to cold, Jr. Am. Med. Assoc., 1936, cvii, 1263. CrossrefGoogle Scholar7. VAUGHAN WT: Practice of allergy, 1939, C. V. Mosby Co., St. Louis. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 7, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPURPURA AS A MANIFESTATION OF PENICILLIN SENSITIVITY*LEO H. CRIEP, M.D., SHELDON G. COHEN, M.D. 1 October 1941Volume 15, Issue 4Page: 743-748KeywordsAllergy and immunologySyncopeUrticaria ePublished: 1 December 2008 Issue Published: 1 October 1941 PDF downloadLoading ...