tbuckley/cabot-search huggingface dataset:
Septal Ablation to Treat Subaortic Dynamic Obstruction Following Transcatheter Aortic Valve Implantation
Authors: Lidia María Carrillo Mora, José Javier Tercero Fajardo, Diana Milena Cruz Sepúlveda, Juan Ramón Gimeno Blanes, Juan García De Lara
Journal: Journal of the American College of Cardiology (2024)

Dynamic obstruction of the left ventricle is an unusual complication that can occur after aortic valve replacement. It is important to be aware of this pathology as it requires different management than normal complications and can rapidly lead to death. We present a case of successful resolution following transcatheter aortic valve implantation.
Access to GLP-1 Weight Loss Drugs in the US, Canada, Switzerland, and Germany
Authors: Kerstin N. Vokinger, Emanuel Nussli, Stacie B. Dusetzina
Journal: JAMA Internal Medicine (2024)

This Viewpoint compares use and costs of glucagon-like peptide 1 (GLP-1) receptor agonists for weight loss between the US and 3 other peer countries.
Progression From Presymptomatic to Clinical Type 1 Diabetes After COVID-19 Infection
Authors: Nadine Friedl, Melanie Sporreiter, Christiane Winkler, Anja Heublein, Florian Haupt, Anette-Gabriele Ziegler, Ezio Bonifacio
Journal: JAMA (2024)

This study examines whether an association exists between COVID-19 infection and progression to clinical diabetes among youth with presymptomatic type 1 diabetes.
Efficacy of a Pain Self-Management Intervention Tailored to People With HIV
Authors: Katie Fitzgerald Jones, Dustin M. Long, Matthew J. Bair, Deana Agil, Lindsay Browne, Greer Burkholder, Olivio J. Clay, Kendall Conder, Amy L. Durr, Claire E. Farel, Kiko King, Bernadette Johnson, Jane M. Liebschutz, William Demonte, Mireille Leone, LaToya Mullen, Sarah Margaret Orris, Tammi Thomas, Mallory Johnson, Sonia Napravnik, Jessica S. Merlin
Journal: JAMA Internal Medicine (2024)

Chronic pain is a common condition for which efficacious interventions tailored to highly affected populations are urgently needed. People with HIV have a high prevalence of chronic pain and share phenotypic similarities with other highly affected populations.
Randomized Clinical Trials That Advance Health and Health Equity
Authors: Tracy Y. Wang, Giselle Corbie, Heather Gwynn Allore, Timothy S. Anderson, Raegan Durant, Ishani Ganguli, Deborah Grady, Cary P. Gross, Mitchell Katz, Lona Mody, Yorghos Tripodis, Sharon K. Inouye
Journal: JAMA Internal Medicine (2024)
Error in Figure
Journal: JAMA Network Open (2024)

Nicholas B. Griffith, MD; Timothy B. Baker, PhD; Brendan T. Heiden, MD, MPHS; Nina Smock, BA; Giang Pham, MPH; Jingling Chen, BS; Justin Yu, MD, MEng; James Reddy, BA; Albert M. Lai, PhD; Eric Hogue, MA; Laura J. Bierut, MD; Li-Shiun Chen, MD, MPH, ScD
Improving Equity in Shared Decision Making
Authors: Yaara Zisman-Ilani, Monica E. Peek
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Defining Levels of US Hospitals’ Pediatric Capabilities
Authors: Kenneth A. Michelson, Elizabeth R. Alpern, Katherine E. Remick, Rebecca E. Cash, Samaa Kemal, Courtney Benjamin Wolk, Carlos A. Camargo, Margaret E. Samuels-Kalow
Journal: JAMA Network Open (2024)

Classifying hospitals across a wide range of pediatric capabilities, including medical, surgical, and specialty services, would improve understanding of access and outcomes.
Enhancing the Methods of a Rapid Virus Testing Study
Authors: Victor Daniel Acuña-Rocha
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Pediatric Complex Chronic Condition System Version 3
Authors: James A. Feinstein, Matt Hall, Amber Davidson, Chris Feudtner
Journal: JAMA Network Open (2024)

Since implementation of the International Statistical Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) in the US, thousands of new or related codes have been added to represent clinical conditions. The widely used pediatric complex chronic condition (CCC) system required a major update from version 2 (V2) to version 3 (V3) to capture the range of clinical conditions represented in the ICD-10-CM.
Substantia Nigra Pathology, Contact Sports Play, and Parkinsonism in Chronic Traumatic Encephalopathy
Authors: Jason W. Adams, Daniel Kirsch, Samantha M. Calderazzo, Fatima Tuz-Zahra, Yorghos Tripodis, Jesse Mez, Michael L. Alosco, Victor E. Alvarez, Bertrand R. Huber, Caroline Kubilus, Kerry A. Cormier, Raymond Nicks, Madeline Uretsky, Evan Nair, Eva Kuzyk, Nurgul Aytan, Jonathan D. Cherry, John F. Crary, Daniel H. Daneshvar, Christopher J. Nowinski, Lee E. Goldstein, Brigid Dwyer, Douglas I. Katz, Robert C. Cantu, Robert A. Stern, Ann C. McKee, Thor D. Stein
Journal: JAMA Neurology (2024)

Parkinsonism is associated with traumatic brain injury and chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with repetitive head impact (RHI) exposure, but the neuropathologic substrates that underlie parkinsonism in individuals with CTE are yet to be defined.
Use of Massage Therapy for Pain, 2018-2023
Authors: Selene Mak, Jennifer Allen, Meron Begashaw, Isomi Miake-Lye, Jessica Beroes-Severin, Gerardo De Vries, Emily Lawson, Paul G. Shekelle
Journal: JAMA Network Open (2024)

Importance Massage therapy is a popular treatment that has been advocated for dozens of painful adult health conditions and has a large evidence base. Objective To map systematic reviews, conclusions, and certainty or quality of evidence for outcomes of massage therapy for painful adult health conditions. Evidence Review In this systematic review, a computerized search was conducted of PubMed, the Allied and Complementary Medicine Database, the Cumulated Index to Nursing and Allied Health Literature, the Cochrane Database of Systematic Reviews, and Web of Science from 2018 to 2023. Included studies were systematic reviews of massage therapy for pain in adult health conditions that formally rated the certainty, quality, or strength of evidence for conclusions. Studies of sports massage therapy, osteopathy, dry cupping or dry needling, and internal massage therapy (eg, for pelvic floor pain) were ineligible, as were self-administered massage therapy techniques, such as foam rolling. Reviews were categorized as those with at least 1 conclusion rated as high-certainty evidence, at least 1 conclusion rated as moderate-certainty evidence, and all conclusions rated as low- or very low–certainty evidence; a full list of conclusions and certainty of evidence was collected. Findings A total of 129 systematic reviews of massage therapy for painful adult health conditions were found; of these, 41 reviews used a formal method to rate certainty or quality of evidence of their conclusions and 17 reviews were mapped, covering 13 health conditions. Across these reviews, no conclusions were rated as high certainty of evidence. There were 7 conclusions that were rated as moderate-certainty evidence; all remaining conclusions were rated as low- or very low–certainty evidence. All conclusions rated as moderate certainty were that massage therapy had a beneficial associations with pain. Conclusions and Relevance This study found that despite a large number of randomized clinical trials, systematic reviews of massage therapy for painful adult health conditions rated a minority of conclusions as moderate-certainty evidence and that conclusions with moderate- or high-certainty evidence that massage therapy was superior to other active therapies were rare.
Surgeon Skill and Perioperative Outcomes in Robot-Assisted Partial Nephrectomy
Authors: Yuzhi Wang, Samantha Wilder, Mahmoud Hijazi, Marquisha D. Myles, Mahin Mirza, Monica Van Til, Thomas Maatman, Khurshid R. Ghani, Brian R. Lane, Craig G. Rogers
Journal: JAMA Network Open (2024)

Technical skill in complex surgical procedures may affect clinical outcomes, and there is growing interest in understanding the clinical implications of surgeon proficiency levels.
Clinician Perceptions of Family-Centered Care in Pediatric and Congenital Heart Settings
Authors: Farah Akram, Annabel E. Webb, Madeleine Pidcock, Michelle A. Farrar, Nadine A. Kasparian
Journal: JAMA Network Open (2024)

Family-centered care recognizes families as central to child health and well-being and prioritizes clinician collaboration with families to ensure optimal pediatric care and outcomes. Clinician interpersonal sensitivity and communication skills are key to this approach.
Securement to Prevent Noncuffed Central Venous Catheter Dislodgement in Pediatrics
Authors: Tricia M. Kleidon, Jessica Schults, Victoria Gibson, Derek J. Roebuck, Deborah Peirce, Ruth Royle, Robert S. Ware, Joshua Byrnes, Elizabeth Andresen, Paula Cattanach, Anna Dean, Colleen Pitt, Malanda Ramstedt, Craig A. McBride, Stephanie Hall, Claire M. Rickard, Amanda J. Ullman
Journal: JAMA Pediatrics (2024)

Catheter dislodgement is a common complication for children with tunneled or peripherally inserted noncuffed central venous catheters (CVCs). A subcutaneous anchor securement system (SASS) may reduce this risk compared with traditional adhesive securement.
Improving Equity in Shared Decision-Making—Reply
Authors: Deepshikha C. Ashana, Kimberly S. Johnson, Christopher E. Cox
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Newborn Screening and Birth Prevalence for Spinal Muscular Atrophy in the US
Authors: Lisa Belter, Jennifer L. Taylor, Erica Jorgensen, Jacqueline Glascock, Sarah M. Whitmire, Jessica J. Tingey, Mary Schroth
Journal: JAMA Pediatrics (2024)

This cross-sectional study describes the collection and use of state-provided data on newborn screening for spinal muscular atrophy.
Nasal epithelial gene expression identifies relevant asthma endotypes in the ATLANTIS study
Authors: Tatiana Karp, Alen Faiz, Jos van Nijnatten, Huib A M Kerstjens, Ilse Boudewijn, Monica Kraft, Judith M Vonk, Martijn C Nawijn, Irene H Heijink, Bianca Beghé, Klaus F Rabe, Alberto Papi, Chris Brightling, Dave Singh, Thys van der Molen, Salman Siddiqui, Stephanie Christenson, Victor Guryev, Maarten van den Berge
Journal: Thorax (2024)

Asthma is an inflammatory airways disease encompassing multiple phenotypes and endotypes. Several studies suggested gene expression in nasal epithelium to serve as a proxy for bronchial epithelium, being a non-invasive approach to investigate lung diseases. We hypothesised that molecular differences in upper airway epithelium reflect asthma-associated differences in the lower airways and are associated with clinical expression of asthma.
Comparison of gallbladder extraction via the subxiphoid port and the supraumbilical port during laparoscopic cholecystectomy: a prospective randomized clinical trial
Authors: Xiwen Ye, Xiaoya Niu, Dan Bai, Yu Cao, Yaling Mao, Huizhen Liu, Yuting Luo, None Fuyu-Li, Nansheng Cheng, Zhen You
Journal: International Journal of Surgery (2024)

Postoperative pain after laparoscopic cholecystectomy (LC) is the most frequent postoperative complaint. To date, gallbladder extraction via the subxiphoid port (SXP) versus the supraumbilical port (SUP) is still controversial. Thus, the authors performed this randomized controlled trial to compare postoperative pain between the SXP and SUP for LC. From June 2021 to June 2023, patients who met the inclusion criteria were randomly assigned to two groups. The perioperative data of both groups were recorded and compared. A total of 253 patients were enrolled in the analysis. There were 126 in the SXP group and 127 in the SUP group. There was no significant difference between the two groups in terms of the duration of gallbladder extraction, whether the incision was extended, the least rate of pain, the average rate of pain, the right-now rate of pain, postoperative pain on the 5th, 7th, and 14th days, postoperative complications and Vancouver Scar scale. However, the SUP group had a lower the worst rate of pain (4.24±2.45 vs. 4.91±2.45, P=0.031) and 3 days of pain (3.35±1.57 vs. 3.75±1.52, P=0.045) than did the SXP group. The influence of pain on general activity (4.51±2.90 vs. 3.76±2.92, P=0.041), mood (3.62±2.66 vs. 2.92±2.36, P=0.028), walking ability (4.40±3.01 vs. 3.66±2.76, P=0.044), and enjoyment of life (3.19±2.68 vs. 2.32±2.34, P=0.007) in the SXP was more severe than that in the SUP. The extraction of the gallbladder via the SUP is superior to that via the SXP because the early postoperative 24 h pain and pain on the third day are mild and do not increase the duration of gallbladder extraction or the risk of infection or hernia.
Data science in pharmaceutical R&amp;D: the DISRUPT-DS industry roundtable
Authors: Najat S. Khan, Thomas Senderovitz, James Weatherall, Janice Branson, Benedikt Egersdoerfer, Eric Genevois-Marlin, Sai Jasti, Mustaqhusain Kazi, Ranjit Kumble, Patrick Loerch, Justine Rochon, Venkat Sethuraman, Matt Studney, Xiaoying Wu, Ryan Copping, Priya Chandran, Madura Jayatunga, Dhruv Jayanth, Christoph Meier
Journal: Nature Reviews Drug Discovery (2024)
Evaluating the effectiveness of cytoreductive surgery in oligometastatic prostate cancer: insights from quantitative analysis and retrospective cohort studies
Authors: Bisheng Cheng, Bingheng Li, Jianhan Fu, Qiong Wang, Tianlong Luo, Zean Li, Shirong Peng, Jilin Wu, Qianghua Zhou, Peng Wu, Hai Huang
Journal: International Journal of Surgery (2024)
The Social Value Misconception in Clinical Research
Authors: Jake Earl, Liza Dawson, Annette Rid
Journal: The American Journal of Bioethics (2024)

Clinical researchers should help respect the autonomy and promote the well-being of prospective study participants by helping them make voluntary, informed decisions about enrollment. However, participants often exhibit poor understanding of important information about clinical research. Bioethicists have given special attention to "misconceptions" about clinical research that can compromise participants' decision-making, most notably the "therapeutic misconception." These misconceptions typically involve false beliefs about a study's purpose, or risks or potential benefits for participants. In this article, we describe a misconception involving false beliefs about a study's potential benefits for non-participants, or its expected social value. This social value misconception can compromise altruistically motivated participants' decision-making, potentially threatening their autonomy and well-being. We show how the social value misconception raises ethical concerns for inherently low-value research, hyped research, and even ordinary research, and advocate for empirical and normative work to help understand and counteract this misconception's potential negative impacts on participants.
Associations of immune checkpoint predictive biomarkers MHC-I and MHC-II with clinical and molecular features in a diverse breast cancer cohort
Authors: Xiaopeng Sun, Laura C. Kennedy, Paula I. Gonzalez-Ericsson, Violeta Sanchez, Melinda Sanders, Charles M. Perou, Melissa A. Troester, Justin M. Balko, Sonya A. Reid
Journal: Clinical Cancer Research (2024)

Immunotherapy (IO) in triple-negative breast cancer (TNBC) has improved survival outcomes, with promising improvements in pCR rates among early high-risk hormone receptor (HR)+/HER2- breast cancers. However, biomarkers are needed to select patients likely to benefit from IO. MHC-I and tumor-specific MHC-II (tsMHC-II) expression are candidate biomarkers for PD-(L)1 checkpoint inhibition but existing data from clinical trials included limited racial/ethnic diversity.
Deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex
Authors: Caleb R. Carr, Katharine H.D. Crawford, Michael Murphy, Jared G. Galloway, Hugh K. Haddox, Frederick A. Matsen, Kristian G. Andersen, Neil P. King, Jesse D. Bloom
Journal: Immunity (2024)

Lassa virus is estimated to cause thousands of human deaths per year, primarily due to spillovers from its natural host, Mastomys rodents. Efforts to create vaccines and antibody therapeutics must account for the evolutionary variability of the Lassa virus's glycoprotein complex (GPC), which mediates viral entry into cells and is the target of neutralizing antibodies. To map the evolutionary space accessible to GPC, we used pseudovirus deep mutational scanning to measure how nearly all GPC amino-acid mutations affected cell entry and antibody neutralization. Our experiments defined functional constraints throughout GPC. We quantified how GPC mutations affected neutralization with a panel of monoclonal antibodies. All antibodies tested were escaped by mutations that existed among natural Lassa virus lineages. Overall, our work describes a biosafety-level-2 method to elucidate the mutational space accessible to GPC and shows how prospective characterization of antigenic variation could aid the design of therapeutics and vaccines.
Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease
Authors: Elisabeth Urbauer, Doriane Aguanno, Nora Mindermann, Hélène Omer, Amira Metwaly, Tina Krammel, Tim Faro, Marianne Remke, Sandra Reitmeier, Stefanie Bärthel, Johannes Kersting, Zihua Huang, Feng Xian, Manuela Schmidt, Dieter Saur, Samuel Huber, Bärbel Stecher, Markus List, David Gómez-Varela, Katja Steiger, Matthieu Allez, Eva Rath, Dirk Haller
Journal: Cell Host & Microbe (2024)

Mitochondrial dysfunction is associated with inflammatory bowel diseases (IBDs). To understand how microbial-metabolic circuits contribute to intestinal injury, we disrupt mitochondrial function in the epithelium by deleting the mitochondrial chaperone, heat shock protein 60 (Hsp60
Sensory choices as logistic classification
Authors: Matteo Carandini
Journal: Neuron (2024)

Logistic classification is a simple way to make choices based on a set of factors: give each factor a weight, sum the results, and use the sum to set the log odds of a random draw. This operation is known to describe human and animal choices based on value (economic decisions). There is increasing evidence that it also describes choices based on sensory inputs (perceptual decisions), presented across sensory modalities (multisensory integration) and combined with non-sensory factors such as prior probability, expected value, overall motivation, and recent actions. Logistic classification can also capture the effects of brain manipulations such as local inactivations. The brain may implement it by thresholding stochastic inputs (as in signal detection theory) acquired over time (as in the drift diffusion model). It is the optimal strategy under certain conditions, and the brain appears to use it as a heuristic in a wider set of conditions.
Propofol anesthesia destabilizes neural dynamics across cortex
Authors: Adam J. Eisen, Leo Kozachkov, André M. Bastos, Jacob A. Donoghue, Meredith K. Mahnke, Scott L. Brincat, Sarthak Chandra, John Tauber, Emery N. Brown, Ila R. Fiete, Earl K. Miller
Journal: Neuron (2024)

Every day, hundreds of thousands of people undergo general anesthesia. One hypothesis is that anesthesia disrupts dynamic stability-the ability of the brain to balance excitability with the need to be stable and controllable. To test this hypothesis, we developed a method for quantifying changes in population-level dynamic stability in complex systems: delayed linear analysis for stability estimation (DeLASE). Propofol was used to transition animals between the awake state and anesthetized unconsciousness. DeLASE was applied to macaque cortex local field potentials (LFPs). We found that neural dynamics were more unstable in unconsciousness compared with the awake state. Cortical trajectories mirrored predictions from destabilized linear systems. We mimicked the effect of propofol in simulated neural networks by increasing inhibitory tone. This in turn destabilized the networks, as observed in the neural data. Our results suggest that anesthesia disrupts dynamical stability that is required for consciousness.
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood
Authors: Olaf Perdijk, Alana Butler, Matthew Macowan, Roxanne Chatzis, Edyta Bulanda, Rhiannon D Grant, Nicola L Harris, Tomasz P Wypych, Benjamin J Marsland
Journal: Immunity (2024)