tbuckley/cabot-search huggingface dataset:
Abstract 2894: Essential Role of ERK 1/2 in Sildenafil-Induced Early and Delayed Cardioprotection in Mice
Authors: Anindita das, Lei Xi, Fadi N Salloum, Yuan J Rao, Rakesh C Kukreja
Journal: Circulation (2008)

Background: Sildenafil (SIL), a potent inhibitor of phosphodiesterase-5 induces powerful protection against myocardial ischemia-reperfusion (I-R) injury through activation of protein kinase G (PKG). However, the downstream targets of PKG in SIL-induced cardioprotection remain unclear. We hypothesized that PKG-dependent activation of survival kinase, ERK may play a critical role in SIL-induced cardioprotection in mice. Methods &amp; Results: Ventricular myocytes were isolated from adult male ICR mice and exposed to 40 min of simulated ischemia (SI) with/without 1 hr pre-incubation of SIL (1 μM). Myocyte necrosis and apoptosis were determined after 1 hr or 18 hrs of reoxygenation (RO) using trypan blue or TUNEL assay, respectively. Pretreatment with SIL protected cardiomyocytes after SI-RO (necrosis 18.5±0.5% and apoptosis 6.6±0.7%; n=4, p&lt;0.001) as compared with controls (necrosis 42.1±1.8% and apoptosis 23.3±0.9%). Co-incubation of PD98059 (20 μM), a selective ERK1/2 inhibitor blocked both anti-necrotic and anti-apoptotic protection in cardiomyocytes. Furthermore, intra-coronary infusion of SIL (1 μM) in Langendorff isolated mouse hearts 10 min prior to zero-flow global I (20 min) and R (30 min) significantly reduced myocardial infarct size (from 29.4±2.4% to 16.0±3.0%; p&lt;0.05, n=6). Co-treatment of PD98059 abrogated SIL-induced protection (33.0±5.9; n=4). To evaluate the role of ERK1/2 in delayed cardioprotection, mice were treated with saline or SIL (0.7 mg/kg i.p.) 24 hours before global I-R in Langendorff mode. PD98059 (1 mg/kg) was administered (i.p.) 30 min before the treatment of SIL. Infarct size was reduced from 27.6±3.3% in saline-treated controls to 6.9±1.2% in SIL-treated mice (P&lt;0.05, n=6). The delayed protective effect of SIL was also abolished by PD98059 (22.5±2.3%). Western Blots revealed that SIL significantly increased phosphorylation of ERK1/2 which was blocked by PKG inhibitor, KT5823 in the heart and adult myocytes. Selective knockdown of PKG in cardiomyocytes with short hairpin RNA of PKG also blocked the phosphorylation of ERK1/2. Conclusion: SIL-induced cardioprotection involves the activation and phosphorylation of ERK which appear to be intimately linked with a PKG-dependent survival pathway. This research has received full or partial funding support from the American Heart Association, AHA Mid-Atlantic Affiliate (Maryland, North Carolina, South Carolina, Virginia &amp; Washington, DC).
Biochemistry and Pathology of Connective Tissue.
Authors: Yūichi Ōtaka
Journal: Annals of Internal Medicine (1975)

the importance of their associated rheumatic manifestations.The chapter about haemophilia demonstrates how much can be done for this daunting problem by an integrated team of haematologists and orthopaedic surgeons.These are but a few examples of the rich clinical seams which the contributors have mined.The series will continue with publication of three issues each year, the next three being devoted to current management of rheumatoid arthritis, systemic lupus erythematosus, and diagnosis and assessment.
A phase II study of single agent OSI-7904L in patients with metastatic or recurrent squamous cell carcinoma of the head and neck (SCCHN)
Authors: B. Hough, M. Posner, C. Chung, J. Hainsworth, J. Horan, J. Chick, M. K. Gibson
Journal: Journal of Clinical Oncology (2009)

e17005 Background: Given the limited efficacy and relative toxicity of chemotherapy for metastatic or recurrent squamous cell carcinoma of the head and neck, further research is needed to both increase the efficacy and decrease the toxicity of treatment. OSI-7904L is a novel liposomal formulation of a non-competitive thymidylate synthase inhibitor. In a phase I study, 12 mg/m2 dosing given every 21 days was both feasible and well tolerated. Methods: This multi-center, two-stage, phase II trial was designed to assess the efficacy and toxicity of OSI-7904L in patients with advanced, refractory SCCHN. A total of 41 patients were to be enrolled by completion of stage II. Enrollment was limited to patients with histologically proven squamous histology, locally recurrent and/or metastatic disease, with no more than one prior chemotherapy regimen. Patients were required to have a performance status of ≤ 2, predicted life expectancy of at least three months and adequate hematopoietic, hepatic and renal function. Efficacy was assessed according to RECIST guidelines, and toxicity was evaluated per CTC AE 3.0. Results: Ten patients enrolled in stage 1. Median age was 60 (range 42–66). Nine were evaluable for response assessment with one withdrawn after one cycle due to a grade 4 papular rash. There were no objective responses while 4 of the 10 patients had stable disease during their first restaging. Median time to progression was 2.5 months for the 9 evaluable patients. Besides the one grade 4 dermatologic reaction, other toxicities were grade 3 fatigue and dehydration, and grade 2 anorexia. Assuming an expected 20% response rate required to initiate enrollment in stage II, the probability of the tenth patient being a responder was less than 3%, thus the study was closed due to lack of response in this population. Conclusions: OSI-7904L was well tolerated similar to the phase I data, but did not demonstrate efficacy in metastatic or recurrent HNSCC patients. Further study of this drug as a single-agent with the current dosing regimen is not recommended. [Table: see text]
Abstract 8899: Mechanism for Dobutamine-Induced Hyperdynamic Transmission to the Relief of Focal Cerebral Ischemia Affected by Vasospasm after Subarachnoid Hemorrhage
Authors: Tatsushi Mutoh, Tatsuya Ishikawa, Shotaro Yoshioka, Taizen Nakase, Akifumi Suzuki
Journal: Circulation (2010)
Abstract 1871: Nebivolol Decreases Human Ventricular Contractility by Activating Beta 3-Adrenoceptors
Authors: Bertrand Rozec, Morteza Erfanian, Karine Laurent, Jean-Noel Trochu, Chantal Gauthier
Journal: Circulation (2006)

Background. Nebivolol is a β-blocker of third generation used in the treatment of heart failure. It associates selective β1-adrenergic antagonist properties with vasodilating endothelial effects me...
Relapses of Diffuse Large B Cell Lymphoma in Rituximab Era Are Limited to the First Two Years after Frontline Therapy
Authors: Tatyana Feldman, Larysa Gromko, Ewelina A Protomastro, Lina Starovoitova, Anthony R. Mato, Chad Glisch, Mona Sadekh, Benjamin Schoener, Susan Stives, Marisa Valentinetti, Mary Timberg, Pritish K. Bhattacharyya, Kar Fai Chow, Xiao Yang, Alan P Skarbnik, Andre Goy
Journal: Blood (2014)
Die Deutsche Chirurgie im Weltkrieg 1914 bis 1918.
Authors: August Borchard, Victor Schmieden
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 130: Markers of Progenitor Cell Recruitment and Differentiation Rise Early During Ischemia and Continue During Resuscitation in a Porcine Model of Acute Ischemia
Authors: Atman P Shah, Scott T Youngquist, Christian D McClung, Ekaterina Tzvetkova, Mohammed A Hanif, John P Rosborough, James T Niemann
Journal: Circulation (2011)

Background: Clinical administration of bone marrow derived stem cells in the setting of acute myocardial infarction (AMI) improves left ventricular ejection fraction. Thymosin beta-4 (TB4) and vasc...
Abstract 16136: High-Fat Diet-Induced Obesity Induces Cardiac Hypertrophy and Augments Adaptive Cardiac ER Stress but does not Exacerbate Post-Infarction Remodeling in Mice
Authors: Guihua Zhou, Allison L Keskey, Mehak Goel, Tariq Hamid, Shang Z Guo, Kenneth R Brittian, Sumanth D Prabhu
Journal: Circulation (2010)

Although obesity increases the risk of developing heart failure (HF), obese subjects with HF have better clinical outcomes than lean subjects (the “obesity paradox”). The importance of metabolic ab...
Abstract 744: Arrhythmogenesis in Heart Failure: Role of Interstitial Fibrosis
Authors: Jorge E Massare, R. Haris Naseem, Jeff M Berry, Farhana Rob, Joseph A Hill
Journal: Circulation (2007)

Background: Sudden cardiac death due to ventricular tachyarrhythmia (VT) accounts for a large number of deaths in patients with heart failure. Several cellular events which occur during pathological remodeling of the failing ventricle are implicated in the genesis of VT, including action potential prolongation, dysregulation of intercellular coupling, and fibrosis. Interestingly, transgenic mice over-expressing constitutively active PKD (caPKD) develop severe heart failure without interstitial fibrosis, an otherwise prominent feature of the disease. The goal here was to define the role of interstitial fibrosis in the proarrhythmic phenotype of failing myocardium. Methods and Results: We performed echocardiographic, electrocardiographic, and in vivo electrophysiologic studies in 8 –10 week old caPKD mice (n=12). Similar studies were performed in mice with load-induced heart failure induced by surgical pressure overload (sTAB, n=10), a model of heart failure with prominent interstitial fibrosis. caPKD and sTAB mice showed similar degrees of ventricular dilation (LV systolic dimension caPKD 2.4±0.8 mm vs 3.0±0.9 sTAB, p=0.18) and severe systolic dysfunction (% fractional shortening caPKD 25±11 vs 28±11 sTAB, p=0.62). Yet, caPKD mice showed minimal interstitial fibrosis, comparable to unoperated controls. With the exception of ventricular refractory period, which was higher in caPKD (48±11 msec vs 36±7 TAB and 40±8 WT, p&lt;0.05), other electrocardiographic and electrophysiologic variables were similar among the 3 groups (p=NS), including heart rate, QT duration, and mean VT threshold. As expected, VT (≥3beats) was readily inducible by programmed stimulation in sTAB mice (7/10). By contrast, VT was less inducible in caPKD mice (4/12; p=0.1 vs TAB and &lt;0.05 vs WT), and uninducible in unoperated controls (0/12). VT was polymorphic in both models, but episodes of VT were both slower (VT cycle length caPKD 58±4.0 msec vs 48±1 sTAB, p=0.016) and longer in caPKD mice (caPKD 1.8±0.7 sec vs 0.47±0.3 sTAB, p=0.038). Conclusion: Interstitial fibrosis contributes to the inducibility, maintenance, and rate of VT in heart failure. These findings highlight the importance of anti-remodeling therapies known to target fibrosis in heart disease.
SAARC: regional cooperation for sustainable health [letter]
Authors: Nishtar S
Journal: BMJ (2004)

The grouping of seven South Asian countries in the framework of the South Asian Association for Regional Cooperation (SAARC www.saarc-sec.org) (figure) presents a sizeable opportunity for regional collaboration. The SAARC region has one of the poorest health indicators in the world—it houses the largest number of people with micronutrient deficiencies and diabetes; carries 40% of the world’s tuberculosis burden and has a high burden of cardiovascular diseases and one of the worst indicators for reproductive health in the world. In addition issues of rural health risks posed by close contact with animal population and high prevalence of zoonotic diseases highlight issues of a regional nature that could be amenable to locally tailored public health strategies. Efforts are under way to forge partnerships in the health sector domain. However the potential within collective regional efforts for sustainable health outcomes remains largely unexplored.  (excerpt)
Principal factor analysis of predictive markers of response and resistance to primary chemo-endocrine treatment in elderly breast cancer (BC) patients
Authors: D. G. Generali, S. Fox, F. M. Buffa, A. Berruti, M. Brizzi, G. Allevi, S. Bonardi, L. Dogliotti, A. Bottini, A. Harris
Journal: Journal of Clinical Oncology (2006)

618 Background: This study was undertaken to identify protein expression patterns able to predict response and resistance to chemo-endocrine therapy in elderly BC patients enrolled in a randomised phase II study. Methods: 114 women with T2–4 N0–1, estrogen receptor positive BC were randomly assigned to 6 months of primary Letrozole (L) (2,5 mg/daily) or L plus oral “metronomic” cyclophosphamide (50 mg/daily) (LC). Expression of 24 markers was assessed before treatment on TMAs. Markers were involved in signalling and angiogenic/hypoxia pathways as follow; erbB2, T regulatory cells, caspase3, BNIP3, phosphorylated ERaplha, CCDN1, mTor, Hif-1α, phd1, phd2, phd3, CA9, COX2, p38, p44, EGFr, PI3k, pAkt, CD31, VEGF, Ki67, p53, bcl2, herb2. Principal factor (PF) analysis attempts to identify underlying factors that explain the correlation patterns within a set of observed variables; here, PF analysis was used to reduce the marker expression data by identifying a small number of PFs that explained most of the variance observed. These PFs were introduced in a multivariate logistic regression (MLR) to study basal protein expression profiles with response to chemo-endocrine treatment. Clinical variables such as treatment, age, tumor size, nodal status, grading and histotype were also included in MLR. Results: 91 out of 113 evaluable patients (80.5%) attained a disease response, 48 patients a complete response (CR) (42.5%) whereas 22 did not respond (19.5%). The first 12 extracted PFs from PF analysis explained 80% of the expression data variance; these were considered in a MLR together with clinical variables. The 4 th PF, mainly representing Hif-1α and p44 expression, and at lower degree EGFr expression, was the only independent predictor of disease response (OD=0.22, p=0.003). The 6 th PF, mainly representing phosphorylated ERalpha expression, was the only independent factor associated with CR (OD=2.036, p=0.023). There was no interaction between these PFs and treatment randomisation. Conclusion: The activated form of ERalpha is with complete response, whereas Hif-1α and p44 were able to discriminate patients resistant to chemo-endocrine treatment. In this latter cohort, specific target therapies can be recommended. No significant financial relationships to disclose.
Coronary Care Medicine: A Practical Approach.
Authors: Elliott M. Antman, John D. Rutherford
Journal: Annals of Internal Medicine (1987)

1. Pathogenesis and Pathology of Ischemic Heart Disease Syndromes.- 2. Clinical Presentation of Ischemic Heart Disease.- 3. Routine Management of Myocardial Infarction.- 4. Cardiac Arrhythmias During Acute Myocardial Infarction.- 5. Management of Cardiac Arrhythmias not Associated with Acute Myocardial Infarction.- 6. Pharmacological Therapy of Cardiac Arrhythmias.- 7. Cardioversion and Defibrillation.- 8. Atrioventricular and Intraventricular Conduction Defects.- 9. Temporary and Permanent Pacemaker Therapy.- 10. Cardiac Arrest and Resuscitation.- 11. Hemodynamic Monitoring.- 12. Complications of Acute Myocardial Infarction.- 13. Myocardial Infarct Size Reduction.- 14. Coronary Artery Spasm.- 15. Post-Hospital Management of Myocardial Infarction.- 16. Prognosis After Hospitalization with Chest Pain or Myocardial Infarction.
Die photographischen Grundlagen des Röntgenbildes.
Authors: Richard Herz
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Receptors and Human Disease.
Authors: Melvin Blecher, Robert S. Bar
Journal: Annals of Internal Medicine (1982)

Bertrand defines the field of paediatric endocrinology. The book incorporates the biology of growth and development with clinical application. Emphasizing molecular biology, it focuses on foetal development, physiology of growth, puberty and immunology. Bertrand presents material of clinical relevance so that generalists in paediatrics and family practice can access information.
PROLAPSE OF THE FEMALE URETHRA
Authors: A R Simpson
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15483: Prevalence and Determinants of Electrocardiographic Abnormalities in Children Undergoing Pre-Participation Screening
Authors: Federico Migliore, Alessandro Zorzi, Mariachiara Siciliano, Pierantonio Michieli, Martina Perazzolo Marra, Barbara Bauce, Ilaria Rigato, Maurizio Schiavon, Sabino Iliceto, Domenico Corrado
Journal: Circulation (2011)

PURPOSE: The study addressed the prevalence, clinical significance and determinants of 12-lead electrocardiographic (ECG) abnormalities in a large and consecutive series of children undergoing pre-...
Influence of Intestinal Bacterial Decontamination Using Metronidazole and Ciprofloxacin or Ciprofloxacin Alone on the Development of Acute Graft-Versus-Host Disease After Marrow Transplantation in Patients With Hematologic Malignancies: Final Results and Long-Term Follow-Up of an Open-Label Prospective Randomized Trial
Authors: Dietrich W. Beelen, Ahmet Elmaagacli, Karl-Dieter Müller, Herbert Hirche, Ulrich W. Schaefer
Journal: Blood (1999)
The Psychical Correlation of Religious Emotion and Sexual Desire.
Authors: James Weir
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A
Authors: Yanmei Li, Yonghong Shi, Lindsay McCaw, You-Jun Li, Fang Zhu, Reg Gorczynski, Gordon S. Duncan, Burton Yang, Yaacov Ben-David, David E. Spaner
Journal: Blood (2015)
Abstract 21285: Copeptin and Nt-proBNP as Precitors of Post-operative Outcome in Patients with Major Vascular Surgery
Authors: Rudolf Jarai, Elisabeth Mahla, Thomas Perkmann, Sylvia Archan, Kurt Huber, Helfried Metzler
Journal: Circulation (2010)

Background and Aim: Nt-proBNP is a well described predictor of postoperative outcome after elective surgery. Copeptin, the C-terminal part of the pro-vasopressin peptide, has been shown to predict ...
Atlas der Histotopographie gesunder und erkrankter Organe.
Authors: Erwin Christeller
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal