tbuckley/cabot-search huggingface dataset:
Survivorship After Cardiogenic Shock
Authors: Eric J. Hall, Sachin Agarwal, C. Munro Cullum, Shashank S. Sinha, E. Wesley Ely, Maryjane A. Farr
Journal: Circulation (2025)

Advances in critical care therapies for patients with cardiogenic shock (CS), including temporary mechanical circulatory support and multidisciplinary shock teams, have led to improved survival to hospital discharge, ranging from 60% to 70%. After their index hospitalization, however, survivors of CS may continue to face cardiac as well as extracardiac sequelae of these therapies and complications for years to come. Most studies in CS have focused primarily on survival, with limited data on long-term recovery measures among survivors. In other forms of critical illness, research indicates that many intensive care unit survivors experience impairments in multiple domains, such as cognitive function, physical ability, and mental health. These impairments, collectively referred to as Post–Intensive Care Syndrome, in turn impact survivors’ quality of life and future prognosis. This review identifies unique aspects of CS–related survivorship, highlights lessons learned from other forms of critical illness, and outlines future research directions to determine specific strategies to enhance recovery and survivorship after CS.
Driving Restrictions and Incapacitation Vulnerability Evaluation After ST-Segment–Elevation Myocardial Infarction: DRIVE-STEMI Study
Authors: Zachary Singer, Harindra C. Wijeysundera, Feng Qiu, Jiming Fang, Ragavie Manoragavan, Christopher S. Simpson, Luiz F. Ybarra
Journal: Circulation (2025)
Letetresgene Autoleucel in Advanced/Metastatic Myxoid/Round Cell Liposarcoma
Authors: Sandra P. D'Angelo, Mihaela Druta, Brian A. Van Tine, David Liebner, Scott M. Schuetze, William D. Tap, Jessica Preston, Sophia Goodison, Jimson W. D'Souza, Gurpreet S. Kapoor, Sunil Suchindran, Stefan Zajic, Aishwarya Bhaskar, Heather Kaczynski, Jaegil Kim, Erika Klohe, Ellie Corigliano, Ioanna Eleftheriadou, Michael J. Nathenson, Neeta Somaiah
Journal: Journal of Clinical Oncology (2025)

PURPOSE The cancer/testis antigen New York esophageal squamous cell carcinoma 1 (NY-ESO-1) is a promising target in myxoid/round cell liposarcoma (MRCLS). METHODS In this pilot study, we assessed the adoptive T-cell therapy NY-ESO-1c 259 T letetresgene autoleucel (lete-cel) in patients with human leukocyte antigen (HLA)-A*02:01–, HLA-A*02:05–, and/or HLA-A*02:06–positive advanced/metastatic NY-ESO-1–expressing MRCLS. Patients underwent a reduced-dose (cohort 1) or standard-dose (cohort 2) lymphodepletion regimen (LDR). The primary end point was investigator-assessed overall response rate (ORR). Safety was assessed through adverse event (AE) reports. Correlative biomarker analyses were performed post hoc. The trial is registered at ClinicalTrials.gov (identifier: NCT02992743 ). RESULTS Of 23 enrolled patients, 10 in cohort 1 and 10 in cohort 2 received lete-cel. Investigator-assessed ORR was 20% (95% CI, 2.5 to 55.6) and 40% (95% CI, 12.2 to 73.8), median duration of response was 5.3 months (95% CI, 1.9 to 8.7) and 7.5 months (95% CI, 6.0 to not estimable [NE]), and median progression-free survival was 5.4 months (95% CI, 2.0 to 11.5) and 8.7 months (95% CI, 0.9 to NE) in cohorts 1 and 2, respectively. AEs included cytokine release syndrome and cytopenias, consistent with T-cell therapy/LDR. Post hoc correlative biomarkers showed T-cell expansion and persistence in both cohorts. CONCLUSION To our knowledge, this study is the first demonstrating the clinical promise of lete-cel in HLA-/NY-ESO-1-positive patients with advanced MRCLS.
De-Escalation Strategies With Immune Checkpoint Blockers in Non–Small Cell Lung Cancer: Do We Already Have Enough Evidence?
Authors: Jordi Remon, Martina Bortolot, Paolo Bironzo, Francesco Cortiula, Jessica Menis, Mariana Brandao, Jarushka Naidoo, Robin van Geel, Noemi Reguart, Oscar Arrieta, Giannis Mountzios, Lizza E.L. Hendriks, Benjamin Besse
Journal: Journal of Clinical Oncology (2025)

Immune checkpoint blockers (ICBs) have revolutionized the treatment of non–small cell lung cancer (NSCLC). Currently, one-dose-fits-all maximalist regimens have been considered the standard of care, with ICBs administered at flat doses regardless of patients’ weight. Treatment duration with ICBs is often arbitrary across stages, ranging from a fixed time point to until disease progression or unacceptable toxicity. However, the pharmacokinetic and pharmacodynamic properties of ICBs differ significantly from those of traditional cytotoxic drugs and the approved and selected doses on the basis of the maximum tolerated dose are often overestimated as there is limited evidence supporting a direct relationship between therapeutic intensity and outcomes. This can lead to overtreatment of patients, resulting in an increased risk of toxicity without enhanced efficacy. In addition, the use of these drugs is associated with significant costs that burden the global health care system and exacerbate disparities in access to care. De-escalating treatment by reducing the dose, duration, and frequency of administration of ICBs could optimize treatment efficacy, reduce toxicities, improve patients' quality of life, and even decrease costs. Ultimately, de-escalation strategies may help to reduce treatment inequalities and to improve drug access worldwide. The aim of this review is to summarize and discuss the main issues and challenges regarding the de-escalation of ICBs in patients with NSCLC, focusing on dose-intensity reduction and treatment duration selection. Moreover, we assess the economic impact of implementing de-escalation approaches.
Unveiling the immune landscape of IDH1-mutant cholangiocarcinoma: Pathways to new therapies
Authors: Binbin Li, Sumera I. Ilyas
Journal: Hepatology (2025)

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN Correspondence Sumera I. Ilyas, Assistant Professor of Immunology and Medicine, Mayo Clinic - Gastroenterology and Hepatology, 200 First Street SW , Rochester, Minnesota 55905. Email: [email protected]
Evaluating the global landscape of suicide helpline services: a global survey across 105 countries
Authors: Gladson Vaghela, Le Van Truong, Vu Thi Thu Trang, Abdelrahman M Makram, I-Chun Hung, Mai Ngoc Luu, Nguyen Hai Nam, Randa Elsheikh, My Duc Thao Trieu, Le Thi Bich Trang, Zeeshan Khan, Cyril Nnaemeka Ikeanyionwu, Engy M Makram, Nguyen Tran Minh Duc, Minh-Hang Nguyen, Tan Weiling Amanda, Zia Baig, Karim Chafee, Shaimaa Yousry Fadel, Thuan Khac Nguyen, Aashish Lamichhane, Nguyen Ngoc Hoang Linh, Mohamed H Khalil, Rahul Shidhaye, Muhammad Ali Hasnain, Lakshmi Vijayakumar, Jeffrey Mayne, Humaira Maheen, Sujita Kumar Kar, Sandersan Onie, Paul Siu Fai Yip, James White, Nguyen Tien Huy
Journal: The Lancet Psychiatry (2025)
Sand and dust storms: a growing global health threat calls for international health studies to support policy action
Authors: Tiantian Li, Aaron J Cohen, Michal Krzyzanowski, Can Zhang, Sophie Gumy, Pierpaolo Mudu, Pallavi Pant, Qian Liu, Haidong Kan, Shilu Tong, Siyu Chen, Utchang Kang, Sara Basart, N'Datchoh Evelyne Touré, Ali Al-Hemoud, Yinon Rudich, Aurelio Tobias, Xavier Querol, Kenza Khomsi, Fatin Samara, Masahiro Hashizume, Massimo Stafoggia, Mazen Malkawi, Shuxiao Wang, Maigeng Zhou, Xiaoming Shi, Guibin Jiang, Hongbing Shen
Journal: The Lancet Planetary Health (2025)

Sand and dust storms increasingly threaten global environmental and public health. To date, 150 countries are directly affected, with more than 100 classified as non-dust source regions. With climate change, these storms are expected to become more frequent and severe. Despite international awareness and initiatives, such as those led by the UN, crucial knowledge gaps continue to hinder effective, evidence-based public responses to sand and dust storms. In this Viewpoint, we review existing gaps in health research and highlight four key research priorities: the comprehensive health effects of sand and dust storms, including short-term and long-term exposures, diseases, regions, and health outcomes; the key particle sizes and toxic components of particles during sand and dust storms; the design of multicentre studies accounting for region-specific exposure patterns; and research on health outcomes attributable to particulate matter mixtures dominated by windblown dust versus other sources. We urgently call for international, collaborative, and multidisciplinary health studies considering sand and dust storm exposure characteristics and for the adoption of scientifically robust epidemiological methods in these studies.
Recommendations to address the shortfalls of the EAT–Lancet planetary health diet from a plant-forward perspective
Authors: Anna-Lena Klapp, Nanine Wyma, Roberta Alessandrini, Catherine Ndinda, Armando Perez-Cueto, Antje Risius
Journal: The Lancet Planetary Health (2025)

Shifting to dietary patterns rich in plants and low in animal-source foods could substantially lower emissions from the food sector while reducing the global burden of non-communicable diseases. The EAT-Lancet Commission proposed the planetary health diet (PHD) to emphasise plant-forward diets and set global targets to guide an urgently needed food-system transformation. However, the PHD's meat-reduction approach has attracted criticism and prompted debate on the potential micronutrient shortfalls of the plant-forward dietary approach. Since the planet simply cannot sustain human diets defaulting towards animal-based solutions, the objective of this Viewpoint is to provide recommendations that address the shortfalls of the PHD, with an emphasis on plant-based sourcing of food. Using a socioecological approach, along with an Integrative Sustainability Framework to evaluate dietary guidelines, in this Viewpoint we recommend seven key thematic areas for further development of the PHD. These themes relate to the bioavailability of micronutrients from plant-based foods, the inclusion of indigenous foods and practices, fortification and supplementation, cultural inclusiveness, and gender-based differences, a broader perspective on processed foods, and strengthening the concept by integrating the One Health approach.
Communicating with policy makers about climate change, health, and their intersection: a scoping review
Authors: Joshua Ettinger, Julia Fine, Kathryn Thier, Nicholas Badullovich, John Kotcher, Edward Maibach
Journal: The Lancet Planetary Health (2025)

Ambitious policies are urgently needed to protect human health from the impacts of climate change. Civil society, including researchers and advocates, can help advance such policies by communicating with policy makers. In this scoping review, we examined what is known about effectively communicating with policy makers to encourage them to act on public health, climate change, or their nexus. We analysed 139 studies published in the literature on health, climate, and their intersection that focused on strategies for communicating with policy makers. Among many other recommendations, the most frequently recommended communication strategies were to tailor messaging to target audiences; share accessible, concise, and timely evidence; and build coalitions and trusted relationships. The studies were largely about health communication to policy makers, were predominantly based in high-income countries, and most frequently used case studies, interviews, and surveys as methods. Further experimental research is needed to test the findings generated by non-experimental methods. Additionally, future research should seek to generate and test communication strategies in more low-income and middle-income countries. Based on this literature, we have produced a list of strategic questions that communicators might wish to consider as they prepare to communicate with policy makers.
Post-growth: the science of wellbeing within planetary boundaries
Authors: Giorgos Kallis, Jason Hickel, Daniel W O'Neill, Tim Jackson, Peter A Victor, Kate Raworth, Juliet B Schor, Julia K Steinberger, Diana Ürge-Vorsatz
Journal: The Lancet Planetary Health (2025)

There are increasing concerns that continued economic growth in high-income countries might not be environmentally sustainable, socially beneficial, or economically achievable. In this Review, we explore the rapidly advancing field of post-growth research, which has evolved in response to these concerns. The central idea of post-growth is to replace the goal of increasing GDP with the goal of improving human wellbeing within planetary boundaries. Key advances discussed in this Review include: the development of ecological macroeconomic models that test policies for managing without growth; understanding and reducing the growth dependencies that tie social welfare to increasing GDP in the current economy; and characterising the policies and provisioning systems that would allow resource use to be reduced while improving human wellbeing. Despite recent advances in post-growth research, important questions remain, such as the politics of transition, and transformations in the relationship between the Global North and the Global South.
Mapping hotspots of zoonotic pathogen emergence: an integrated model-based and participatory-based approach
Authors: Julianne Meisner, Anna Baines, Isaac Ngere, Patricia J Garcia, Chatchawal Sa-Nguansilp, Nguyen Nguyen, Cheikh Niang, Kevin Bardosh, Thuy Nguyen, Hannah Fenelon, McKenzi Norris, Stephanie Mitchell, Cesar V Munayco, Noah Janzing, Rane Dragovich, Elizabeth Traylor, Tianai Li, Hanh Le, Alyssa Suarez, Yassar Sanad, Brandon T Leader, Judith N Wasserheit, Eric Lofgren, Erin Clancey, Noelle A Benzekri, Lindsey Shields, Chana Rabiner, Stephanie Seifert, Peter Rabinowitz, Felix Lankester
Journal: The Lancet Planetary Health (2025)

An increase in pandemics of zoonotic origin has led to a growing interest in using statistical prediction to identify hotspots of zoonotic emergence. However, the rare nature of pathogen emergence requires modellers to impose simplifying assumptions, which limit the model's validity. We present a novel approach to hotspot mapping that aims to improve validity by combining model-based insights with expert knowledge. We conducted a systematic literature review to identify predictors for zoonotic emergence events in three priority virus families (Filoviridae, Coronaviridae, and Paramyxoviridae). We searched PubMed, Web of Science, Agricola, medRxiv, bioRxiv, Embase, CAB Global Health, and Google Scholar on Oct 14-28, 2021, with no restrictions on language or the date of publication. Articles suggested by subject matter experts and those identified by a review of reference lists were also included. We used regularised regression to fit a model to the data extracted from the literature and produced maps of ranked risk. In a series of workshops in five countries (Kenya, Peru, Senegal, Thailand, and Viet Nam), experts in zoonotic diseases produced qualitative hotspot maps based on their expertise, which were compared with the model-derived maps. 425 articles were analysed, from which 19 predictors and 1068 outcome events were identified. The in-sample misclassification error was 0·365, and 89% of participant-selected zones were ranked as moderate or high risk by the model. Participant-selected zones were too large to be actionable without further refinement. Discordance was probably due to missing predictors for which no valid data exist, and homogeneity imposed by our global model. Concordance between the two sets of maps supports the validity of each. Because model-based and participatory strategies have non-overlapping limitations, the results can be harmonised to minimise bias, and model-based results could be used to refine participant-selected zones. This approach shows potential for refining deployment of countermeasures to prevent future pandemics. US Agency for International Development.
Associations between weather extremes and faecal contamination along pathogen transmission pathways in rural Bangladeshi households: a prospective observational study
Authors: Caitlin G Niven, Mahfuza Islam, Anna Nguyen, Jessica A Grembi, Andrew Mertens, Amy J Pickering, Laura H Kwong, Mahfuja Alam, Debashis Sen, Sharmin Islam, Mahbubur Rahman, Leanne Unicomb, Alan E Hubbard, Stephen P Luby, John M Colford, Benjamin F Arnold, Jade Benjamin-Chung, Ayse Ercumen
Journal: The Lancet Planetary Health (2025)

Weather extremes are predicted to influence pathogen exposure but their effects on specific faecal-oral transmission pathways are not well investigated. We evaluated associations between extreme rain and temperature during different antecedent periods (0-14 days) and Escherichia coli along eight faecal-oral pathways in rural Bangladeshi households. We used data from the WASH Benefits Bangladesh cluster-randomised controlled trial (NCT01590095). E coli was enumerated in hand rinses from children younger than 5 years and their mothers, food, stored drinking water, tubewells, captured flies, ponds, and courtyard soil using IDEXX Quanti-Tray/2000 in nine rounds over 3·5 years and spatiotemporally matched to daily weather data. We used generalised linear models with robust standard errors to estimate E coli count ratios (ECRs) associated with extreme rain and temperature, defined as greater than the 90th percentile of daily values during the study period. A total of 26 659 samples were collected during the study period. Controlling for temperature, extreme rain on the sampling day was associated with increased E coli in food (ECR=3·13 [95% CI 1·63-5·99], p=0·0010), stored drinking water (ECR=1·98 [1·36-2·88], p=0·0004), and ponds (ECR=3·46 [2·34-5·11], p<0·0001), and reduced E coli in soil (ECR=0·36 [0·24-0·53], p<0·0001). Extreme rain the day before sampling was associated with reduced E coli in tubewells (ECR=0·10 [0·02-0·62], p=0·014). Associations were similar for rainfall 1-7 days before sampling and slightly attenuated for rainfall 14 days before sampling. Controlling for rainfall, extreme temperature on the sampling day was associated with increased E coli in stored drinking water (ECR=1·49 [1·05-2·12], p=0·025) and food (ECR=3·01 [1·51-6·01], p=0·0020). Associations with temperature were similar for all antecedent periods and particularly pronounced for food. Neither rainfall nor temperature were consistently associated with E coli on hands and flies. In rural Bangladesh, measures to control enteric infections following weather extremes should focus on water treatment and safe storage to reduce contamination of drinking water and food stored at home and on reducing exposure to surface waters. Bill & Melinda Gates Foundation, National Institutes of Health, World Bank.
Engineered allogeneic stem cells orchestrate T lymphocyte driven immunotherapy in immunosuppressive leptomeningeal brain metastasis
Authors: Nobuhiko Kanaya, Waleed Seddiq, Kok-Siong Chen, Yoshinori Kajiwara, Lucia Moreno Lama, Paulo Borges, Shinji Kuroda, Hiroaki Wakimoto, Khalid Shah
Journal: JNCI Journal of the National Cancer Institute (2025)

Abstract Background Immune-checkpoint inhibitors have shown clinical benefit in non-small cell lung cancer (NSCLC) derived brain metastasis (BM), however, their efficacy in lung to leptomeningeal brain metastasis (LLBM) remains poor. Methods A paired matched RNA expression dataset of patients with NSCLCs and BMs was analyzed to idenfiy BM specific suppressive tumor microenvironment (TME) features. Next, we created immune-competent LLBM mouse models that mimic clinical LLBM. We evaluated the efficacy of intrathecal (IT) delivery of allogeneic stem cells (SCs) engineered to release single-chain variable fragment anti-PD-1 (scFvPD-1). To enhance tumor cell killing and subsequent modulation of the immune TME, we explored the therapeutic activity of dual SCs releasing oncolytic herpes simplex virus (oHSV) and scFvPD-1 and profiled immune and metabolic consequences. Results RNA sequencing analysis of primary NSCLCs and BMs revealed an immune-suppressive TME with reduced immune cells and increased PD-1+ T cells in BMs. We showed significantly decreased immune cells and increased PD-1+ T cells in the TME of LLBM compared to primary NSCLC tumors in LLBM mouse tumor models. Next, we showed that locoregional IT treatment with SC releasing scFvPD-1, but not conventional systemic injection of anti-PD-1 antibody, suppressed tumor growth and improved survival in our immune-competent LLBM models. Furthermore, dual SCs releasing oHSV and scFvPD-1 (SC-oHSV/scFvPD-1) enhanced therapeutic outcomes by inducing oHSV-mediated immunogenic cell death, activating anti-tumor T cell signaling, and disrupting oxidative phosphorylation, which sensitized tumors to cisplatin. Conclusion Locoregional delivery of SC-oHSV/scFvPD-1 effectively targets the immune-suppressive TME in LLBM, providing a promising strategy for treating LLBM.
Successful resection of a large adenoma of the descending duodenum by endoscopic submucosal dissection
Authors: Xiaolin Chen, Hongna Lu, Qide Zhang, Liangshun Zhang, Ting Weng, Minying Zhu, Feng Xu
Journal: Endoscopy (2025)

A 59-year-old man was admitted to our hospital with a diagnosis of hypopharyngeal carcinoma. During gastroscopy, a mass was identified in the descending part of the duodenum, and biopsy results indicated the presence of low grade intraepithelial neoplasia. An enhanced computed tomography of the upper abdomen demonstrated that the wall of the descending part of the duodenum was markedly thickened, exhibiting a local mass-like convexity into the lumen, which was markedly and homogeneously enhanced ([Fig. 1]), with mesenteric arterial blood supply. Additionally, the local lumen of the duodenum was narrowed, and the surrounding fat space was clear. Following the exclusion of contraindications, a decision was taken to proceed with endoscopic submucosal dissection (ESD).
Three-point traction functions like full-face traction: facilitating rapid excision of a laterally spreading tumor
Authors: Hui Liu, Zhi Guo Wang
Journal: Endoscopy (2025)

With the progression of technology, endoscopic submucosal dissection (ESD) has been increasingly applied in clinical practice. However, ESD still faces technical challenges in certain cases. To reduce the difficulty of the procedure, shorten the operation time, and decrease the incidence of complications, various traction devices have been invented and employed clinically [1] [2] [3]. Additionally, owing to limitations of single-point traction, multipoint traction techniques have been developed to achieve more efficient dissection. These multipoint traction techniques represent technological improvements and innovations based on traction devices [4] [5]. Herein, we introduce a novel multipoint traction method that enhances traction force, enabling rapid dissection of the lesion.
Successful hemostasis of colonic diverticular bleeding using single-balloon-assisted endoscopy and endoscopic band ligation in a patient with difficult total colonoscopy
Authors: Takaaki Kishino, Takayuki Sawa, Toshihito Tsuchihashi
Journal: Endoscopy (2025)

Recently, cases of colonic diverticular bleeding (CDB) in elderly individuals have significantly increased [1]. Effective management of CDB is crucial, as severe cases may require transarterial embolization (TAE) or surgery, which can be life-threatening for elderly patients with multiple comorbidities [2]. Given the invasiveness of surgery and TAE, minimally invasive treatments, such as endoscopic hemostasis, are preferable, especially for elderly patients. However, traditional endoscopic methods may sometimes fail to reach the bleeding site, necessitating alternative approaches. Here, we report a case of recurrent CDB in a 91-year-old woman who was treated successfully by a novel approach using a single-balloon-assisted endoscopy and endoscopic band ligation.