Insulin and Carbohydrate Tolerance
Authors: William M. Brace
Journal: Annals of Internal Medicine (1927)

Article1 October 1927Insulin and Carbohydrate ToleranceWILLIAM M. BRACE, A.B., M.D.WILLIAM M. BRACE, A.B., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-4-203 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONSince the discovery of insulin by Banting (1), there has been a great deal written concerning the cure of diabetes mellitus with this new therapeutic agent. MacCallum (2), Boyd and Robinson (3) have given us some meagre hope of a cure with microscopical evidence in favor of the regeneration of the islands of Langerhans; while Newburgh (4), Harrison (5), and others (6, 7) present clinical evidence of a negative nature concerning a cure. With this controversy still unsettled, five cases were carefully selected from our diabetic clinic with this question ever present. Is there any evidence of a cure...Bibliography(1) BANTING FG: Pancreatic extracts in diabetes. Canad. M. A. J., 12:141, Mar., 1922. Insulin in treatment of diabetes mellitus. J. Metabolic Research, 2:547, Nov., Dec., 1922. MedlineGoogle Scholar(2) MACCALLUM WG: Hypertrophy of Islands of Langerhans in diabetes mellitus. J. A. M. Sc., 133-432. Google Scholar(3) BOYDROBINSON GLWL: Evidence of regeneration of pancreas in an insulin treated case of diabetes. Am. J. Path., 1:135, March, 1925. MedlineGoogle Scholar(4) NEWBURGH LH: Does insulin increase tolerance? Boston Med. & Surg. J., 190-9-351, Feb. 28, 1924. CrossrefGoogle Scholar(5) HARRISON GA: Can insulin produce even a partial cure in human diabetes mellitus? Quart. J. of Med., 19:223, Jan., 1926. CrossrefGoogle Scholar(6) LEYTON O: To what extent does insulin possess a curative influence? Practitioner, 114:117, Feb., 1925. Google Scholar(7) GUDEMAN J: Wiener klinische wochenschuft, Vienna 37-721. Abst. J. A. M. A., 83:653. Google Scholar(8) NEWBURGHMARSH LHPL: Use of high fat diet in treatment of diabetes mellitus. Arch. Int. Med., 26:647, 1920. (b) Further observations on the use of a high fat diet in the treatment of diabetes mellitus. Arch. Int. Med., 31:455, April, 1923. (c) NEWBURGH, L. H.: High fat diet in treatment of diabetes mellitus. M. Clinics N. Am., 6:1119, March, 1923. CrossrefGoogle Scholar(9) WOODYATT RT: Objects and method of diet adjustment in diabetes. Arch. Int. Med., 28:125, 1921. CrossrefGoogle Scholar(10) SHAFFERHARTMAN PAAF: The iodometric determination of copper and its use in sugar analysis. II. Methods for determination of reducing sugars in blood, urine, milk and other solutions. J. B. C., 45:365, 1920-21. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Mich.*From the Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan; aided in part by the Frederick Stearns Fellowship, Detroit, Michigan. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInsulin and Carbohydrate Tolerance*ELLIOTT P. JOSLIN, M.D. 1 October 1927Volume 1, Issue 4Page: 203-211KeywordsCarbohydratesDiabetes mellitusFellowshipsInsulinRegenerative medicine ePublished: 1 December 2008 Issue Published: 1 October 1927 PDF downloadLoading ...