tbuckley/cabot-search huggingface dataset:
Challenges and opportunities in training cancer researchers
Authors: Brian Keith, Danny R. Welch, Nishtha Agarwal, Caroline Blair, Ifeanyi Beverly Chukwudozie, Lalita A. Shevde, Lawrence H. Boise, Kerry L. Burnstein, Toni M. Antalis, Kathleen L. O’Connor, Sorab N. Dalal, Sheridan Ellis, Harikrishna Nakshatri
Journal: Nature Cancer (2025)
The impact of common and rare genetic variants on bradyarrhythmia development
Authors: Lu-Chen Weng, Joel T. Rämö, Sean J. Jurgens, Shaan Khurshid, Mark Chaffin, Amelia Weber Hall, Valerie N. Morrill, Xin Wang, Victor Nauffal, Yan V. Sun, Dominik Beer, Simon Lee, Girish N. Nadkarni, ThuyVy Duong, Biqi Wang, Tomasz Czuba, Thomas R. Austin, Zachary T. Yoneda, Daniel J. Friedman, Anne Clayton, Matthew C. Hyman, Renae L. Judy, Allan C. Skanes, Kate M. Orland, Timothy M. Treu, Matthew T. Oetjens, Alvaro Alonso, Elsayed Z. Soliman, Honghuang Lin, Kathryn L. Lunetta, Jesper van der Pals, Tariq Z. Issa, Navid A. Nafissi, Heidi T. May, Peter Leong-Sit, Carolina Roselli, Seung Hoan Choi, Goncalo Abecasis, Aris Baras, Michael Cantor, Giovanni Coppola, Aris Economides, Luca A. Lotta, John D. Overton, Jeffrey G. Reid, Alan Shuldiner, Christina Beechert, Caitlin Forsythe, Erin D. Fuller, Zhenhua Gu, Michael Lattari, Alexander Lopez, Thomas D. Schleicher, Maria Sotiropoulos Padilla, Louis Widom, Sarah E. Wolf, Manasi Pradhan, Kia Manoochehri, Ricardo H. Ulloa, Xiaodong Bai, Suganthi Balasubramanian, Andrew Blumenfeld, Boris Boutkov, Gisu Eom, Lukas Habegger, Alicia Hawes, Shareef Khalid, Olga Krasheninina, Rouel Lanche, Adam J. Mansfield, Evan K. Maxwell, Mrunali Nafde, Sean O’Keeffe, Max Orelus, Razvan Panea, Tommy Polanco, Ayesha Rasool, William Salerno, Jeffrey C. Staples, Marcus B. Jones, Lyndon J. Mitnaul, Habib R. Khan, Stacey Knight, Richard Karlsson Linnér, Connie R. Bezzina, Samuli Ripatti, Susan R. Heckbert, J. Michael Gaziano, Ruth J. F. Loos, Bruce M. Psaty, J. Gustav Smith, Emelia J. Benjamin, Dan E. Arking, Daniel J. Rader, Svati H. Shah, Dan M. Roden, Scott M. Damrauer, Lee L. Eckhardt, Jason D. Roberts, Michael J. Cutler, M. Benjamin Shoemaker, Christopher M. Haggerty, Kelly Cho, Aarno Palotie, Peter W. F. Wilson, Patrick T. Ellinor, Steven A. Lubitz
Journal: Nature Genetics (2025)
Prioritizing infant mental health: a research-driven pathway for action
Authors: Anusha Lachman, Berna Gerber, Marlette Burger, Fiona Ross, Juan Bornman, Tracey Smythe, Astrid Berg, Heather Brookes, Graeme Hoddinott, Helena Kruger, Ziyanda Majombozi, Michelle Pentecost, Frenette Southwood
Journal: Nature Medicine (2025)
An evaluation framework for clinical use of large language models in patient interaction tasks
Authors: Shreya Johri, Jaehwan Jeong, Benjamin A. Tran, Daniel I. Schlessinger, Shannon Wongvibulsin, Leandra A. Barnes, Hong-Yu Zhou, Zhuo Ran Cai, Eliezer M. Van Allen, David Kim, Roxana Daneshjou, Pranav Rajpurkar
Journal: Nature Medicine (2025)
Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits
Authors: Sarah M. Brotman, Julia S. El-Sayed Moustafa, Li Guan, K. Alaine Broadaway, Dongmeng Wang, Anne U. Jackson, Ryan Welch, Kevin W. Currin, Max Tomlinson, Swarooparani Vadlamudi, Heather M. Stringham, Amy L. Roberts, Timo A. Lakka, Anniina Oravilahti, Lilian Fernandes Silva, Narisu Narisu, Michael R. Erdos, Tingfen Yan, Lori L. Bonnycastle, Chelsea K. Raulerson, Yasrab Raza, Xinyu Yan, Stephen C. J. Parker, Johanna Kuusisto, Päivi Pajukanta, Jaakko Tuomilehto, Francis S. Collins, Michael Boehnke, Michael I. Love, Heikki A. Koistinen, Markku Laakso, Karen L. Mohlke, Kerrin S. Small, Laura J. Scott
Journal: Nature Genetics (2025)
Recent progress of soft and bioactive materials in flexible bioelectronics
Authors: Xiaojun Wu, Yuanming Ye, Mubai Sun, Yongfeng Mei, Bowen Ji, Ming Wang, Enming Song
Journal: Cyborg and Bionic Systems (2025)

Materials that establish functional, stable interfaces to targeted tissues for long-term monitoring/stimulation equipped with diagnostic/therapeutic capabilities represent breakthroughs in biomedical research and clinical medicine. A fundamental challenge is the mechanical and chemical mismatch between tissues and implants that ultimately results in device failure for corrosion by biofluids and associated foreign body response. Of particular interest is in the development of bioactive materials at the level of chemistry and mechanics for high-performance, minimally invasive function, simultaneously with tissue-like compliance and in vivo biocompatibility. This review summarizes the most recent progress for these purposes, with an emphasis on material properties such as foreign body response, on integration schemes with biological tissues, and on their use as bioelectronic platforms. The article begins with an overview of emerging classes of material platforms for bio-integration with proven utility in live animal models, as high performance and stable interfaces with different form factors. Subsequent sections review various classes of flexible, soft tissue-like materials, ranging from self-healing hydrogel/elastomer to bio-adhesive composites and to bioactive materials. Additional discussions highlight examples of active bioelectronic systems that support electrophysiological mapping, stimulation, and drug delivery as treatments of related diseases, at spatiotemporal resolutions that span from the cellular level to organ-scale dimension. Envisioned applications involve advanced implants for brain, cardiac, and other organ systems, with capabilities of bioactive materials that offer stability for human subjects and live animal models. Results will inspire continuing advancements in functions and benign interfaces to biological systems, thus yielding therapy and diagnostics for human healthcare.
A Vascularized Multilayer Chip Reveals Shear Stress Induced Angiogenesis in Diverse Fluid Conditions
Authors: Tao Yue, Huiying Yang, Yue Wang, Ning Jiang, Hongze Yin, Xiaoqi Lu, Na Liu, Yichun Xu
Journal: Cyborg and Bionic Systems (2025)

Tissues larger than 400 μm in size lacking microvascular networks cannot survive for long periods of time in vitro. The development of microfluidic technology provides an efficient research tool for constructing microvascular models in vitro. However, traditional single-layer microfluidic chips faced the limitation of spatial layout and could not provide diverse fluidic environments within a single chip. In this paper, we present a novel microfluidic chip design with a 3-layer configuration that utilizes a polycarbonate (PC) porous membrane to separate the culture fluid channels from the tissue chambers, featuring flexibly designable multitissue chambers. PC porous membranes act as the capillary in the vertical direction, enabling precise hydrogel patterning and successfully constructing a microfluidic environment suitable for microvascular tissue growth. The chip demonstrates the ability to build microvascular networks of different shapes such as triangle, rectangle, and inverted triangle on a single chip for more than 10 days. The microvascular networks cultured for 12 days were successfully perfused with 70-kDa fluorescein isothiocyanate, which indicated that the generated networks had good barrier properties. A correlation between tissue chamber shape and shear stress was demonstrated using COMSOL, and a preliminary validation of the flow direction of interstitial flow and the important effect of shear stress on microvascular growth was demonstrated by vascularization experiments. This flexible and scalable design is ideal for culturing multiple vascularized organ tissues on a single microfluidic chip, as well as for studying the effects of different fluidic factors on microvascular growth.
Earthworm-inspired multimodal pneumatic continuous soft robot enhanced by winding transmission
Authors: Jianbin Liu, Pengcheng Li, Zhihan Huang, Haitao Liu, Tian Huang
Journal: Cyborg and Bionic Systems (2025)

This paper presents an earthworm-inspired multimodal pneumatic continuous soft robot enhanced by wire-winding transmission. First, a derived overlapped continuous control law based on multiple peristaltic waves is introduced to effectively improve the motion performance of the robot. Second, by applying the wire-winding transmission method, the extension of one segment is simultaneously transformed into the contraction of other segments, achieving coordinated deformation and making it more similar to real earthworms. In addition, an autonomous obstacle-avoidance control strategy based on contact force sensing is developed to enhance the environmental adaptability of the robot. Based on these methods, an earthworm-inspired soft robot that can perform multimodal movements with autonomous obstacle-avoidance ability and enhanced motion efficiency is developed. A series of experiments including in- and cross-plane crawling, obstacle avoidance steering, and pipeline crawling are conducted to validate the robot's multimodal motion capabilities. The robot can achieve a speed of 6.65 mm/s (36.0 × 10-3 bl/s) during in-plane crawling movement and 1.66 mm/s (8.97 × 10-3 bl/s) during pipeline crawling movement. In terms of the in-plane crawling speed, the robot surpasses other robots of the same type. In conclusion, the robot's multimodal capabilities and enhanced motion efficiency demonstrate superior overall performance, and the robot has good potential for medical and industrial applications.
SegRap2023: A benchmark of organs-at-risk and gross tumor volume Segmentation for Radiotherapy Planning of Nasopharyngeal Carcinoma
Authors: Xiangde Luo, Jia Fu, Yunxin Zhong, Shuolin Liu, Bing Han, Mehdi Astaraki, Simone Bendazzoli, Iuliana Toma-Dasu, Yiwen Ye, Ziyang Chen, Yong Xia, Yanzhou Su, Jin Ye, Junjun He, Zhaohu Xing, Hongqiu Wang, Lei Zhu, Kaixiang Yang, Xin Fang, Zhiwei Wang, Chan Woong Lee, Sang Joon Park, Jaehee Chun, Constantin Ulrich, Klaus H Maier-Hein, Nchongmaje Ndipenoch, Alina Miron, Yongmin Li, Yimeng Zhang, Yu Chen, Lu Bai, Jinlong Huang, Chengyang An, Lisheng Wang, Kaiwen Huang, Yunqi Gu, Tao Zhou, Mu Zhou, Shichuan Zhang, Wenjun Liao, Guotai Wang, Shaoting Zhang
Journal: Medical Image Analysis (2025)
Male preference for TERT alterations and HBV integration in young-age HBV-related HCC: implications for sex disparity
Authors: Jin Seoub Kim, Hye Seon Kim, Kwon Yong Tak, Ji Won Han, Heechul Nam, Pil Soo Sung, Sung Won Lee, Jung Hyun Kwon, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Jeong Won Jang
Journal: Clinical and Molecular Hepatology (2025)

Hepatocellular carcinoma (HCC) exhibits significant sex disparities in incidence, yet its molecular mechanisms remain unclear. We explored the role of telomerase reverse transcriptase (TERT) genetic alterations and hepatitis B virus (HBV) integration, both known major contributors to HCC, in sex-specific risk for HBV-related HCC.
Glucose‐Responsive Zn(II)‐Porphyrin COF Adhesive Hydrogels With Dual‐Active Sites and GOX‐Like Activity for Accelerated Wound Healing
Authors: Jin Wu, Tao Meng, Xiaoqian Zhang, Songtao Tang, Lei Liu, Jing Xue, Xiaohui Liu, Junjun Wang, Jiyue Wen, Danyou Hu, Guiyang Zhang
Journal: Advanced Healthcare Materials (2025)

Abstract Effective glycemic control is paramount for optimal wound healing in diabetic patients. Traditional antibacterial and anti‐inflammatory treatments, while important, often fall short in addressing the hyperglycemic conditions of diabetic wounds. Therefore, the development of novel therapeutic strategies for accelerating diabetic wound healing has garnered escalating attention. Covalent organic frameworks (COFs) are an emerging class of crystalline porous polymers constructed through strong covalent bonds. Their exceptional structural tunability renders them as an ideal platform for advanced therapeutic applications. Herein, two redox‐responsive Zn(II)‐coordinated porphyrin COF hydrogels are constructed, which demonstrate rapid blood glucose reduction in localized tissues, along with improved angiogenesis, reactive oxygen species (ROS) scavenging, and photothermal antimicrobial capacities within the hyperglycemic blood environment of diabetic patients, thereby effectively controlling infections and concurrently promoting wound healing. Specifically, COFs with built‐in dual active sites, i.e., disulfide or diselenide moieties, can be cleaved by ROS, releasing Zn(II) ions that possess antibacterial and tissue‐repairing properties. Furthermore, the Zn(II)‐porphyrin COF exhibits glucose oxidase (GOX)‐like activity, catalyzing the conversion of glucose into non‐glucose metabolites. This synergistic combination of glucose‐responsive Zn(II) release and GOX‐like activities effectively restores tissue redox balance and improves the wound microenvironment, offering a promising strategy for the diagnosis and treatment of diabetic wounds.
Amivantamab Plus Lazertinib in Patients With EGFR-mutant Non-small Cell Lung Cancer (NSCLC) After Progression on Osimertinib and Platinum-based Chemotherapy: Results From CHRYSALIS-2 Cohort A
Authors: Benjamin Besse, Koichi Goto, Yongsheng Wang, Se-Hoon Lee, Melina E Marmarelis, Yuichiro Ohe, Reyes Bernabe Caro, Dong-Wan Kim, Jong-Seok Lee, Sophie Cousin, Eiki Ichihara, Yongsheng Li, Luis Paz-Ares, Akira Ono, Rachel E Sanborn, Naohiro Watanabe, Maria Jose de Miguel, Carole Helissey, Catherine A Shu, Alexander I Spira, Pascale Tomasini, James Chih-Hsin Yang, Yiping Zhang, Enriqueta Felip, Frank Griesinger, Saiama N Waqar, Antonio Calles, Joel W Neal, Christina S Baik, Pasi A Jänne, S Martin Shreeve, Joshua C Curtin, Bharvin Patel, Michael Gormley, Xuesong Lyu, Jun Chen, Pei-Ling Chu, Janine Mahoney, Leonardo Trani, Joshua M Bauml, Meena Thayu, Roland E Knoblauch, Byoung Chul Cho
Journal: Journal of Thoracic Oncology (2025)
Persistence and/or Senescence: Not So Lasting at Last?
Authors: Clemens A. Schmitt
Journal: Cancer Research (2025)

Therapy-exposed surviving cancer cells may have encountered profound epigenetic remodeling that renders these drug-tolerant persisters candidate drivers of particularly aggressive relapses. Typically presenting as slow-to-nongrowing cells, persisters are senescent or senescence-like cells. In this issue of Cancer Research, Ramponi and colleagues study mTOR/PI3K inhibitor–induced embryonic diapause–like arrest (DLA) as a model of persistence in lung cancer and melanoma cells and compare this persister condition with therapy-induced senescence in the same cells. The DLA phenotype recapitulated some but not all features attributed to senescent cells, lacking, for instance, an inflammatory secretome otherwise known as the senescence-associated secretory phenotype. A CRISPR dropout screen pointed to methyl group–providing one-carbon metabolism and further to H4K20me3-mediated repression of senescence-associated secretory phenotype–related IFN response genes selectively in DLA-like persister cells. Conversely, inhibition of H4K20-active KMT5B/C methyltransferases derepressed inflammatory programs and was toxic in DLA cells. These findings not only suggest exploitable vulnerabilities of DLA-like persister cells but also unveil general technical and conceptual challenges of cultured multipassage cell line–based persister studies. Collectively, the approach chosen and insights obtained will stimulate a productive scientific debate on senescence-like features and their reversibility across drug-tolerant persister cells. See related article by Ramponi et al., p. 32
Phase 2 Open-Label Study of Sacituzumab Govitecan as Second-Line Therapy in Patients With Extensive-Stage Small Cell Lung Cancer: Results From TROPiCS-03
Authors: Afshin Dowlati, Anne C. Chiang, Andrés Cervantes, Sunil Babu, Erika Hamilton, Shu Fen Wong, Andrea Tazbirkova, Ivana Gabriela Sullivan, Cédric van Marcke, Antoine Italiano, Jilpa Patel, Sabeen Mekan, Tia Wu, Saiama N. Waqar
Journal: Journal of Thoracic Oncology (2025)

The phase 2 TROPiCS-03 study evaluated the efficacy/safety of sacituzumab govitecan (SG) as second-line treatment in patients with previously treated extensive-stage small cell lung cancer (ES-SCLC).
A Prospective Phase II Trial of First-line Osimertinib for Patients with EGFR Mutation-positive Non-small Cell Lung Cancer and Poor Performance Status (OPEN/TORG2040)
Authors: Tomoya Fukui, Nobuaki Mamesaya, Toshiaki Takahashi, Kazuma Kishi, Takahiro Yoshizawa, Takaaki Tokito, Koichi Azuma, Kei Morikawa, Satoshi Igawa, Yusuke Okuma, Yuta Yamanaka, Shinobu Hosokawa, Takashi Kasai, Ken Masubuchi, Shinji Nakamichi, Masaharu Aga, Jiichiro Sasaki, Akiko Kada, Akiko M Saito, Katsuhiko Naoki, Hiroaki Okamoto
Journal: Journal of Thoracic Oncology (2025)
ATGL regulates renal fibrosis by reprogramming lipid metabolism during the transition from AKI to CKD
Authors: Xiaofan Li, Jianwen Chen, Jun Li, Yixuan Zhang, Jikai Xia, Hongjian Du, Chunjia Sheng, Mengjie Huang, Wanjun Shen, Guangyan Cai, Lingling Wu, Xueyuan Bai, Xiangmei Chen
Journal: Molecular Therapy (2025)
Adaptive lags, illusions and common interest
Authors: Carl Brusse, Kim Sterelny
Journal: Behavioral and Brain Sciences (2024)

Abstract The explanatory model proposed by Sijilmassi et al. appeals to fitness interdependence, and is highly plausible for small-scale societies. We argue that it is less so in the context of the larger societies that much of their empirical evidence is drawn from, and that this is because fitness interdependence does not readily scale up in the way the model requires.
Myths of trauma and myths of cooperation: Diverse consequences of history for societal cohesion
Authors: Michał Bilewicz, Aleksandra Bilewicz
Journal: Behavioral and Brain Sciences (2024)

Abstract We propose that historical myths fall into two distinctive categories: Traumatic and cooperative. Traumatic myths, highlighting collective suffering, can undermine trust and foster conspiracy theories, whereas cooperative myths, emphasizing collective action, enhance group cohesion and within-group coalition building. Psychological and sociological evidence supports these divergent impacts of historical myths both in nations and social movements.
What about language?
Authors: Antonio Benítez-Burraco
Journal: Behavioral and Brain Sciences (2024)

Abstract Myths about a remote shared past can certainly promote cooperation between distantly related people, seemingly via their impact on our social cognition, and ultimately facilitate the achievement of complex tasks in large-scale societies. Nonetheless, the creation and transmission of these complex narratives are not possible without the parallel development of sophisticated language(s), endowed with properties like displacement (enabling mental travels in space and time) and complex syntax (enabling the assembly and communication of complex thoughts).
“We are one people”: Group myths also draw cues from self-concept formation
Authors: Eli Elster, Luke Glowacki
Journal: Behavioral and Brain Sciences (2024)

Abstract Sijilmassi et al. suggest that group myths explaining the shared history of a people succeed and propagate by leveraging cognitive cues from fitness interdependence. We offer an alternative and mutually compatible account rooting the success of group myths in cues from a different cognitive domain: The development of self-concepts.
Myth as model: Group-level interpretive frameworks
Authors: Cody Moser
Journal: Behavioral and Brain Sciences (2024)

Abstract I argue that while recruitment might explain some of the design features of historical myths, origin myths in general more importantly provide shared narrative frameworks for aligning and coordinating members of a group. Furthermore, by providing in-group members with shared frameworks for interfacing with the world, the contents of myths likely facilitate the selection of belief systems at the group-level.
Myths and prestige in Hindu nationalist politics
Authors: Radha Sarkar, Amar Sarkar
Journal: Behavioral and Brain Sciences (2024)

Abstract Sijilmassi et al. offer a myth-based framework that is particularly useful in understanding the rising tide of Hindu nationalism in contemporary India. We propose that the success of these myths lies partly in drawing upon the evolved human capacity for prestige-based status to induce a sense of belonging and identification with high-prestige Hindu social groups.
Uncertainty reduction as an alternative explanation of historical myths
Authors: David J Grüning, Joachim I Krueger
Journal: Behavioral and Brain Sciences (2024)

Abstract We agree with Sijilmassi et al. that historical myths are a tool for coalition recruitment. We argue, however, that a close fit between an evolved entity and an identified function does not imply that the latter is the critical evolutionary trigger. We also propose an alternative individual-centric explanation: Historical myths reduce uncertainty by providing cognitive and behavioral guidance.
Coalitional psychology and the evolution of nationalistic cultures
Authors: Amine Sijilmassi, Lou Safra, Nicolas Baumard
Journal: Behavioral and Brain Sciences (2024)

Abstract The commentaries addressed various aspects of our account of historical myths. We respond by clarifying the evolutionary theory of coalitional psychology that underlies our claims (R1). This addresses concerns about the role of fitness interdependence in large groups (R2), cultural transmission processes (R3), alternative routes to nation-building (R4) and the role of proximal mechanisms (R5). Finally, we evaluate alternative theories (R6) and discuss directions for future research (R7).
Limited evidence that fitness interdependence produces historical origin myths
Authors: Andreas Wimmer
Journal: Behavioral and Brain Sciences (2024)

Abstract This commentary points out some theoretical lacuna in the argument and then evaluates, in a preliminary way, its main comparative empirical hypotheses. It finds very limited support for the observable implications of the evolutionary theory. By contrast, the historical remoteness of foundational myths is closely associated with how long a society has been ruled by a centralized state, pointing at the important role of political history.
Historical myths are believed because audiences are socially motivated
Authors: Shuai Shao, Michael Barlev
Journal: Behavioral and Brain Sciences (2024)

Abstract Do people believe in historical myths because they are manipulated by coalitional recruiters, or because it is in their interests to do so? The target article gives somewhat conflicting explanations. We propose that the audiences of historical myths are socially rather than epistemically motivated – they believe and propagate historical myths as a way of signaling their coalitional commitments.
Beyond our “ancient roots”: Toward a broader understanding of the motivational power of societal meta-narratives
Authors: Laura Akers
Journal: Behavioral and Brain Sciences (2024)

Abstract The “historical myths” addressed in the target article are but one type of societal meta-narrative, a cognitive framework for understanding the story of one's group: Its origins, purpose, turning points, threats and opportunities, key relationships, and the appropriate affect for group members. Engagement with the broader literature on meta-narratives, including political and sacred myths, and on group entitativity is recommended.
The social identity approach offers a more parsimonious and complete explanation of historical myths’ function and characteristics
Authors: Peter Kardos
Journal: Behavioral and Brain Sciences (2024)

Abstract The social identity approach offers a more parsimonious and more comprehensive explanation for historical myths’ assumed coalition-building function than the target article's proposed mechanism based on fitness interdependence. Target article's assertion that social identity theory cannot explain certain characteristics of historical myths is based on a narrow interpretation of the social identity approach.