tbuckley/cabot-search huggingface dataset:
Dr. Morton: Pioneer in the Use of Ether
Authors: Rachel Baker, Lawrence T. Dresser
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of assays for measuring plasma paracetamol
Authors: A L Jones, D R Jarvie, D Simpson, L F Prescott, R. FitzPatrick, T. Hassan, V. Ward, G. Bodiwala
Journal: BMJ (1998)

Egleston et al report a significant difference in plasma paracetamol concen trations assayed with the AcetaSite bench assay and a standard laboratory assay. Rapid and accurate determinations of plasma paracetamol concentrations are crucial in the expeditious and appropriate administration of antidotal treatment, which prevents severe liver damage if given sufficiently early in the course of poisoning.
Abstract 16564: Stimulation of a Nitrate-Nitrite-NO Pathway Reduces Angiotensin II-Mediated Contraction of Renal Microcirculation
Authors: Xiang Gao, Andreas Patzak, Mauricio Sendeski, Ulf Eriksson, Jon O Lundberg, Erik G Persson, Mattias Carlström
Journal: Circulation (2011)

BACKGROUND: Reduced NO bioavailability in the kidney increases preglomerular reactivity, which may contribute to hypertension. Inorganic nitrate and nitrite can be reduced in vivo and emerge as sub...
Abstract 13609: Prognostic Impact of Pulmonary Vascular Resistances Estimated by Cardiac Magnetic Resonance in Chronic Heart Failure With Reduced Ejection Fraction
Authors: Óscar Fabregat-Andrés, Jordi Estornell-Erill, Francisco Ridocci-Soriano, Andres Cubillos-Arango, Bruno Bochard-Villanueva, Pilar García-González, Lorenzo Facila, Rafael Payá-Serrano, Salvador Morell, Julio Cortijo
Journal: Circulation (2014)

Introduction: Pulmonary hypertension is an indicator of worse prognosis in chronic heart failure (HF). As reported in recent years, pulmonary vascular resistances (PVR) could be accurately estimated by cardiac magnetic resonance (CMR).

Hypothesis: We sought to assess the prognostic utility of noninvasive calculation of PVR in patients with systolic HF.

Methods: Prospective registry of patients with left ventricular ejection fraction (LVEF) <40% and admitted for acute decompensated HF from July 2011 to April 2014. Readmission for HF and all-cause mortality were considered as primary endpoint at follow-up.

Results: 105 patients (65.7 years, LVEF 26.0%, ischemic 46%) were included. Patients with primary event had higher PVR: 6.93±1.9 vs. 4.67±1.7 Wu \[Wood units\] (p<0.001). In multivariate Cox regression analysis, PVR ≥5.2 Wu (cutoff point according ROC curve) was independently associated with increased risk of primary event at 10 months follow-up (HR 4.1 [95% CI 1.5-11.2], p=0.007)(see Table). Kaplan-Meier curve shows event-free survival in both groups according PVR (see Figure; time in days).

Conclusions: Noninvasive estimation of PVR by CMR might be useful in risk stratification of patients with systolic HF, irrespective of etiology, right ventricular ejection fraction or presence of LGE.

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Abstract 2393: Similar Long-Term Outcomes After PCI Success, PCI Failure, and no PCI in the Occluded Artery Trial (OAT)
Authors: Christopher E Buller, Vladimir Dzavik, Sandra A Forman, Witold Ruzyllo, Pawel E Buszman, Lampros K Michalis, G. B. John Mancini, Jean Renkin, Matthias E Pfisterer, Boban Thomas, Gervasio A Lamas, Judith S Hochman
Journal: Circulation (2007)

Background: The Occluded Artery Trial (OAT) showed that a strategy of routine percutaneous coronary interventions (PCI) for occluded infarct-related coronary arteries identified up to 28 days post-MI does not reduce the primary end point of death, MI or class IV CHF compared to medical therapy alone (MED). However, PCI was not universally attempted in patients assigned PCI, and was not always successful when attempted. Moreover, some MED patients underwent early PCI. Using an as-treated analysis, we compared the outcomes of (1) successfully-treated PCI patients to medically-treated MED patients, and (2) PCI-assigned patients according to PCI success versus failure. Methods: Of 2201 patients randomized in OAT (2166 + 35 substudy), 1101 were assigned PCI and 1100 to MED. PCI assignment was categorized as attempted and successful (Success), attempted and unsuccessful (Fail), or No Attempt. MED assignment was categorized as medical only (Med Only) or crossover (X-Over) if PCI of the occlusion was performed in ≤30 days. Life table estimates of primary and secondary outcomes were calculated to compare as-treated categories. Results: Baseline characteristics of PCI Success and MED Only groups were similar. Compared to PCI Success, PCI Fail patients were more likely to be male, with higher rates of prior PCI, Killip Class 2– 4, and higher LV end-systolic sphericity index. No significant differences in primary or secondary outcomes were observed between PCI Success versus MED Only, or between PCI Success and PCI Fail. Med X-Over and PCI No Attempt groups were small. Conclusions: As-treated analysis does not reveal important differences in outcome, whether the comparison is between those with PCI success versus medical therapy alone, or between PCI success and PCI failure. These data indicate that the primary intention-to-treat results of OAT would not be altered by higher PCI success rates. 60-Month Life Table Event Rate Estimates
RANDOM BREATH TESTING NOW. ROADSIDE CHECKPOINTS WOULD BE NO AFFRONT TO FREEDOM
Authors: D Gloag
Journal: BMJ (1991)

This short article advocates the use of random breath testing in Great Britain. The proposed amendment to the law provides for random breath tests at roadside checkpoints. Regulations would permit roadside checks at which either all vehicles or a sample of vehicles could be stopped by a constable in uniform for the administration of breath tests. Roadside checkpoints would be authorized in writing and clearly signposted. As a deterrent to drinking before driving its great virtues are its high visibility and the fact that such tests could be encountered anywhere and at any time. Experience from abroad, notably in Scandinavia and Australia, supports its introduction. In New South Wales for example, the average number of fatal and serious accidents related to alcohol fell by one third in the first 4 years of random breath testing. The hospital and social security savings were over 20 times the initial cost of implementing the scheme. (TRRL) (Author/TRRL)
Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694
Authors: Yiming Zhong, Shuai Dong, Kelsey Thornton, Anjali Mishra, Pierluigi Porcu, Michael Bradshaw, Angelina Bisconte, Timothy Owens, Erik Verner, Ken Brameld, Jens Oliver Funk, Ronald Hill, Amy J. Johnson, Jason A Dubovsky
Journal: Blood (2014)
Abstract 16211: Activation of Endothelial Toll Like Receptor 3 Impairs Endothelial Function and Promotes Atherosclerosis
Authors: Sebastian Zimmer, Martin Steinmetz, Tobias Asdonk, Gunther Hartmann, Georg Nickenig
Journal: Circulation (2011)

Rationale: Atherosclerosis is chronic inflammatory diseases characterized by activation of the innate and acquired immune system. Specialized protein receptors of the innate immune system recognize...
Chronic forearm pain
Authors: C M Colles, A G Pusey, J Brooks, L C Bainbridge
Journal: BMJ (1997)

Gulf war illness Why it took so long to decide to investigateEditor-As it is now six years since the Gulf war, it is reasonable to ask why the problem of Gulf war syndrome has not been resolved. 1 As surgeon general in 1991-4 I want to comment on the unravelling timetable during these six years.At no time have we denied that Gulf veterans have been ill-indeed, whenever possible we have actively recommended their appropriate medical management.Secondly, despite press reports, we have always kept an open mind on the presence of a specific Gulf war syndrome.The Gulf conflict in 1990-1 itself was short, casualties mercifully few, and the sickness rates unremarkable; likewise, when troops returned to the UK the daily sickness rate did not increase.Also at that stage little evidence existed of psychiatric illness or post-traumatic stress syndrome.Some 18 to 24 months later, however, we became aware of a campaign by lawyers to recognise a specific Gulf illness.Up to 200 people were on their books, but despite widespread appeals for them to come forward, including two television appeals, only 15 approached the armed forces medical services.Not surprisingly, among these 15 no pattern of illness emerged.They were all managed appropriately.As we were keen to solve the problem, in October 1993 we appointed a single consultant physician, Group Captain Coker, to see all such patients.At first only a trickle of patients came forward-even by June 1994 (three and half years later) he had seen only 30 patients.Over the next two years, however, these numbers increased so that by January 1997, 1100 had been registered, 920 had been seen and fully investigated, and results had been completed and analysed in 519.A preliminary paper in the summer of 1996 concluded: "From our small database it would not appear that there is a unique cluster of symptoms which would suggest a new pattern of illness in veterans." 2 There was, however, a higher than normal incidence of psychiatric and stress related illness.A large battery of tests was uniformly performed on all the patients, with further investigations as necessary.Now it has been agreed that full epidemiological studies are to be undertaken into the incidence of ill health among UK Gulf war veterans and into their reproductive health.In answering the criticism that these expensive studies should have been instigated earlier, I have tried to show how difficult it has been to decide exactly when this decision could have been made.Early on there were very few patients and no evidence of a syndrome.At all stages we have liaised with our counterparts in the United States.They embarked a little earlier on similar studies as they had similar results to their investigations but dealt with greater numbers.An important reason for writing this letter is because our armed forces may well be placed in similar alien environments in future and we owe it to them to provide the best medical support, which of course includes planned protective and scientifically justified measures against likely threats to their health.
Effect of CTLA-4 blockade on lymphocyte resistance to regulatory T cells in advanced melanoma and use as a surrogate marker of efficacy of tremelimumab
Authors: F. Ghiringhelli, C. Menard, C. Mateus, S. Horn, L. Zitvogel, C. Robert
Journal: Journal of Clinical Oncology (2008)

3021 Background: Anti-CTLA-4 monoclonal antibody has led to encouraging antitumor activity associated with immune related adverse events in patients with metastatic melanoma. However, mechanisms of action and surrogate biological markers of efficacy have not been reported so far. Methods: We monitored the immune responses of ten metastatic melanoma patients included a phase II clinical trial evaluating the efficacy of a second line of therapy with tremelimumab: 10 mg/kg injected every three months. Characterization of blood leukocyte subpopulations as well as T cells and CD4+ CD25+ regulatory T cells (Treg) functions were studied. Results: Prior to therapy, advanced melanoma patients presented with a severe CD4+ and CD8+ T cell lymphopenia associated high number of functional T reg. After one month of treatment, tremelimumab restored the effector and memory CD4+ and CD8+ T cell pool and TCR-dependent T cell proliferation that became resistant to Treg-mediated suppression. There was a statistically significant correlation between progression-free survival and the acquisition of a biological response defined as the resistance of peripheral lymphocytes to Treg inhibitory effects (obtained in 7/10 patients) and/or to tremelimumab-induced augmentation of IP-10 serum levels. Indeed, median progression-free survival was 90 days in responders versus 30 days in non responders, (Hazard Ratio: 0.009, 95% CI [0.0005 to 0.015]). Conclusions: CTLA-4 blockade using tremelimumab induces lymphocyte resistance to regulatory T cells that could be a surrogate marker for activity. No significant financial relationships to disclose.
Esophageal Cancer Located at the Neck and Upper Thorax Treated with Concurrent Chemoradiation: A Single-Institution Experience
Authors: Shulian Wang, Zhongxing Liao, Yuan Chen, Joe Y. Chang, Melanda Jeter, Thomas Guerrero, Jaffer Ajani, Alexandria Phan, Stephen Swisher, Pamela Allen, James D. Cox, Ritsuko Komaki
Journal: Journal of Thoracic Oncology (2006)
The HLA System
Authors: Jan Klein, Akie Sato
Journal: New England Journal of Medicine (2000)

Deficiencies of HLA MoleculesA clinician's attention is normally drawn to a system only when it malfunctions. The HLA system is no exception in this regard, but in contrast to other systems, it also arouses interest when it functions well — too well, in fact. The most dramatic malfunction of the HLA system occurs when its genes falter in their expression, resulting in HLA class I or class II deficiencies (the bare lymphocyte syndrome, in which "bare" refers to the low level of HLA molecules on the cell surface). Severe cases of HLA deficiencies are, in fact, not caused by . . .
Diseases of the Intestines. A Text-Book for Practitioners and Students of Medicine.
Authors: Max Einhorn
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17733: Pulmonary Artery Systolic Pressure by Echocardiography and Outcomes in Stable Outpatients with Heart Failure
Authors: Andreas Kalogeropoulos, Sarawut Siwamogsatham, Lothar Roessig, Song Li, Ayman Tahhan, Robert T Cole, Divya Gupta, Catherine N Marti, Mihai Gheorghiade, Vasiliki Georgiopoulou, Javed Butler
Journal: Circulation (2012)
Outline of Bacteriology.
Authors: Henry A. Bartels
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 16662: Serum Albumin Levels Predicts Ischemic Stroke in the Community
Authors: Emil Hagström, Bernice Wiberg, Johan Ärnlöv
Journal: Circulation (2010)

Objective:  Low levels of serum (s-) albumin have been associated with cardiovascular diseases and death. In patients with acute stroke, low levels of s-albumin have been shown to be associated with increased mortality and to be predictive of heart failure in the general population. Levels of albumin have been linked to inflammatory activity and coagulation status. However, the association between s-albumin and the development stroke in the community is limited.   Methods:  In a prospective, community-based study of 1048 elderly men without stroke or transient ischemic attack at baseline (mean age 71 years, the ULSAM study) the association between s-albumin and a combined endpoint of fatal and non-fatal ischemic stroke was investigated.   Results:  During follow-up (median 8.8 years), 123 individuals suffered from ischemic stroke. In multivariable Cox-regression analyses adjusting for established risk factors for stroke (age, hypertension, diabetes, electrocardiographic left ventricular hypertrophy, atrial fibrillation, smoking and hypercholesterolemia), lower s-albumin was associated with increased risk of stroke (hazard ratio for 1-SD increase of s-albumin, 0.80, 95% CI 0.66-0.96, p=0.017). S-albumin levels also predicted ischemic stroke after further adjustment for variables reflecting inflammatory status (IL-6 and CRP). S-albumin was not associated with subarachnoid or subdural hemorrhage.   Conclusion:  In a large community-based sample of elderly men, s-albumin predicted ischemic stroke, also after accounting for established risk factors and for variables reflecting inflammation status. Additional studies are warranted to investigate if s-albumin is a modifiable risk factor.
Chorea and Choreiform Affections.
Authors: William Osler
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Organization and Administration of Group Medical Practice
Authors: Twentieth Century Fund, Good Will Fund, Dean A. Clark, Katharine G.
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Principles of Therapeutics.
Authors: Fraser, Francis R. , Sir
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A biomimetic Schlemm's canal inner wall: A model to study outflow physiology, glaucoma pathology and high-throughput drug screening
Authors: Cula N. Dautriche, Dennis Szymanski, Matthew Kerr, Karen Y. Torrejon, Magnus Bergkvist, Yubing Xie, John Danias, W.D. Stamer, Susan T. Sharfstein
Journal: Biomaterials (2015)