tbuckley/cabot-search huggingface dataset:
Associations of abusive supervision among collegiate athletes from equity-deserving groups
Authors: Edward B Runquist, Oluwasanmi O Adenaiye, Mojdeh Sarzaeim, Jeffery Milroy, David Wyrick, Yetsa A Tuakli-Wosornu
Journal: British Journal of Sports Medicine (2025)

Objective To examine differences in abusive/supportive coach supervision experienced by collegiate athletes across race/ethnicity, gender, sexual orientation and disability; determine the impact of coach characteristics on abusive supervision prevalence; and explore outcomes related to team culture, athlete autonomy, perceived coach leadership skills and perceived concern for athletes’ well-being. Methods Cross-sectional analysis of the 2021–2022 National Collegiate Athletic Association (NCAA) myPlaybook survey on 3317 athletes (aged ≥18 years). The survey captured self-reported demographics, sport type (team vs individual, lean vs non-lean) and multiple validated measures reflecting abusive/supportive coaching styles. Structural equation modelling identified associations while controlling for confounders. Results Overall, 18.6% (n=618) of athletes reported some form of abusive supervision. After adjusting for covariates, participating in team sport (OR=1.10, 95% CI 1.03 to 1.17) and having a disability (OR=1.17, 95% CI 1.04 to 1.31) were associated with higher odds of reporting abusive supervision. No significant differences were found based on athlete race/ethnicity, gender identity or sexual orientation. Coaches demonstrating attentiveness to athletes’ needs (OR=0.82, 95% CI 0.73 to 0.92) and respect for their input (OR=0.89, 95% CI 0.80 to 1.00) had lower odds of reported abusive supervision. Conclusion Nearly one-fifth of this NCAA cohort experienced abusive coach supervision. Disability and team sport participation were significantly associated with increased reports, whereas race/ethnicity, gender identity or sexual orientation showed no significant differences. In disabled and team sport athletes, sustained verbal/non-verbal abuse had a negative impact on athletes’ perception of team culture, autonomy, coaches’ leadership skills and coaches’ concern for their well-being. Coaching and leadership styles remain critical educational targets for providing safe sport environments for all athletes.
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein
Authors: Shujing Xu, Ya Wang, Dazhou Shi, Shuo Wang, Lijun Qiao, Ge Yang, Yang Zhou, Xinyong Liu, Shuo Wu, Yuhuan Li, Peng Zhan
Journal: Acta Pharmaceutica Sinica B (2025)
Killing the Killers: Natural Killer Cell Therapy Targeting Glioma Stem Cells in High-Grade Glioma
Authors: Poorva Poorva, Jensen Mast, Bihui Cao, Mitesh V Shah, Karen E Pollok, Jia Shen
Journal: Molecular Therapy (2025)

High-grade gliomas (HGGs), including glioblastoma (GBM) in adults and diffuse intrinsic pontine glioma (DIPG) in children, are among the most aggressive and deadly brain tumors. A key factor in their resilience is the presence of glioma stem cells (GSCs), which drive tumor initiation, progression, and resistance to treatment. Targeting and eradicating GSCs holds potential for curing both GBM and DIPG. Natural Killer (NK) cells, as part of the innate immune system, naturally recognize and destroy malignant cells. Recent advances in NK cell-based therapies, such as chimeric antigen receptor (CAR)-NK cells, NK cell engagers, and NK cell-derived exosomes, offer promising approaches for treating GBM and DIPG, particularly by addressing the persistence of GSCs. This review highlights these advancements, explores challenges such as the brain-blood barrier and the immunosuppressive tumor microenvironment, and proposes future directions for improving and clinically advancing these NK cell-based therapies for HGGs.
Targeting S100A8/A9-NCF1 Axis in Tumor microenvironment to Prevent Tumor Metastasis by Self-assembled Peptide Nanofibers
Authors: Yajing Guo, Zhifei Zhang, Hongxia Huang, Ye Wu, Lixin Yin, Yang Zhou, Feiqing Ding, Sheng Hong, Nicole F. Steinmetz, Hui Cai
Journal: Molecular Therapy (2025)
An innovative approach to close large mucosal defects post-endoscopic submucosal sissection: threads combined with endoclips
Authors: Jia Xu, Weixing Yang, Zhongqiong Wang, Muhan Lü, Xiaowei Tang
Journal: Endoscopy (2025)

Endoscopic submucosal dissection (ESD) is an effective minimally invasive treatment for early gastrointestinal cancers, offering benefits such as larger resection areas and high cure rates [1]. However, post-ESD procedures often leave large mucosal defects, creating significant complications and obstacles for clinical closure [2] [3]. Endoclips are commonly used for closure, but they can be ineffective for large defects where direct closure is difficult [4].
Closure of refractory gastrocutaneous fistula using submucosal dissection and over-the-scope clip assisted by a standard clip
Authors: Eukene Rojo, Simona Agazzi, Mamadou Diakite, Pierre Lafeuille, Florian Rostain, Jérôme Rivory, Mathieu Pioche
Journal: Endoscopy (2025)

Percutaneous endoscopic gastrostomy is performed to gain enteral nutritional access in patients with impaired swallowing. However, gastrocutaneous fistula (GCF) may persist in up to 25% of cases following tube removal [11]. Endoscopic submucosal dissection (ESD) to re-epithelialize the fistulous tract, combined with closure using an over-the-scope (OTS) clip, has been reported as a safe and effective approach for managing persistent GCF [22] [33] [44]. A twin grasper is commonly used to pull the GCF into the OTS clip before the clip is deployed. A recently introduced, mantis-like claw clip – Mantis clip (Boston Scientific, Marlborough, Massachusetts, USA) – has demonstrated excellent efficacy in closing large gastrointestinal defects [55]. This reopenable, rotatable, through-the-scope clip features anchor prongs designed to securely grasp wound edges. Here, we describe a case in which we combined ESD of the GCF with closure using an OTS clip assisted by the Mantis clip, eliminating the need for a twin grasper and reducing costs.
XMT-2056, a HER2-Directed STING Agonist Antibody-Drug Conjugate, Induces Innate Anti-Tumor Immune Responses by Acting on Cancer Cells and Tumor-Resident Immune Cells
Authors: Raghida A. Bukhalid, Jeremy R. Duvall, Kelly Lancaster, Kalli C. Catcott, Naniye Malli Cetinbas, Travis Monnell, Caitlin Routhier, Joshua D. Thomas, Keith W. Bentley, Scott D. Collins, Elizabeth Ditty, Timothy K. Eitas, Eugene W. Kelleher, Pamela Shaw, Jahna Soomer-James, Elena Ter-Ovanesyan, Ling Xu, Jeffrey Zurita, Dorin Toader, Marc Damelin, Timothy B. Lowinger
Journal: Clinical Cancer Research (2025)

Abstract Purpose: Targeted tumor delivery may be required to potentiate the clinical benefit of innate immune modulators. The objective of the study was to apply an antibody-drug conjugate approach to STING agonism and develop a clinical candidate. Methods: XMT-2056, a HER2-directed STING-agonist antibody-drug conjugate (ADC), was designed, built, and tested in pharmacology and toxicology studies. The ADC was compared to a clinical benchmark intravenously administered STING agonist. Results: XMT-2056 achieved tumor-targeted delivery of the STING agonist upon systemic administration in mice and induced innate anti-tumor immune responses; single dose administration of XMT-2056 induced tumor regression in a variety of tumor models with high and low HER2 expression. Notably, XMT-2056 demonstrated superior efficacy and reduced systemic inflammation compared to a free STING agonist. XMT-2056 exhibited concomitant immune-mediated killing of HER2-negative cells specifically in the presence of HER2-positive cancer cells, supporting the potential for activity against tumors with heterogenous HER2 expression. The antibody does not compete for binding with trastuzumab or pertuzumab, and a benefit was observed when combining XMT-2056 with each of these therapies as well as with trastuzumab-deruxtecan (T-Dxd) ADC. The combination of XMT-2056 with anti-PD-1 conferred benefit on anti-tumor activity and induced immunological memory. XMT-2056 was well tolerated in nonclinical toxicology studies. Conclusion: These data provide a robust preclinical characterization of XMT-2056 and provide rationale and strategy for its clinical testing.
Underwater endoscopic submucosal dissection using gel immersion for early gastric cancer with situs inversus totalis
Authors: Takahiro Muramatsu, Masakatsu Fukuzawa, Takashi Kawai, Midori Mizumachi, Yoshitaka Utsumi, Toshitaka Nagao, Takao Itoi
Journal: Endoscopy (2025)

Situs inversus totalis (SIT) is relatively rare, with an incidence of 1 in 10.000 individuals [1]. SIT is characterized by mirror-image transposition of the thoracoabdominal viscera. Endoscopic submucosal dissection (ESD) of early gastric cancer with SIT has been performed with the patient in the right lateral position to avoid submersion [2] [3]; however, a different standing position for the endoscopist as well as different positioning of the peripheral equipment are required. The use of gel during endoscopic treatment to overcome anatomical challenges and improve the visual field has been reported [4] [5]. We report successful ESD of early gastric cancer with SIT during which scope maneuverability and the visual field were improved under low intraluminal pressure via water and gel immersion (Video 1).
Visualized, radiation-free diagnosis and treatment of biliary stone complexes from migrated surgical clips via peroral cholangioscopy
Authors: Yu Tang, Junyi Zhuo, Min Lin, Xianfei Zhong
Journal: Endoscopy (2025)

Postoperative clip migration into the common bile duct (CBD) is a rare complication of laparoscopic biliary surgery. The migrated clips may serve as niduses for stone formation [1]. This is a report of cholangioscopy-guided diagnosis and treatment of biliary stone-clip complexes.
Magnetic bead embedded in abdominal cavity successfully retrieved by endoscopy
Authors: Zhihao Chen, Zhiling Li, Yue Li, Wanwei Liu, Dahui Huang, Min Yang, Zhigang Zeng
Journal: Endoscopy (2025)

A 2-year-old boy presented with loss of appetite and recurrent cough with expectoration for 1 year. Abdominal radiography performed 3 months prior revealed a circular, bead-like high-density shadow in the upper abdomen. Eleven magnetic beads were successfully extracted via gastroscopy at a local hospital; however, subsequent abdominal X-ray indicated that one bead remained in a fixed position ([Fig. 1]).
Novel method of biopsy for a bile duct lesion in the hepatic hilum with a new slim cholangioscope using a tapered-tip sheath
Authors: Kojiro Tanoue, Hirotsugu Maruyama, Yoshinori Shimamoto, Tatsuya Kurokawa, Yuki Ishikawa-Kakiya, Akira Higashimori, Yasuhiro Fujiwara
Journal: Endoscopy (2025)

Recently, several studies have reported the efficacy of a new slim cholangioscope in endoscopic retrograde cholangiopancreatography (ERCP) [1] [2] [3] [4]. This cholangioscope is notable for its ease of insertion into narrow bile ducts compared with conventional cholangioscopes. However, one limitation is that cholangioscopy-guided biopsy cannot be performed due to the absence of a forceps channel. We present a novel biopsy method for bile duct lesions in the hepatic hilum with a new slim cholangioscope (DRES Slim Scope and CMOS Camera; Japan Lifeline Co. Ltd., Tokyo, Japan) using a tapered-tip sheath (ERCP Guide Sheath; Olympus, Tokyo, Japan).
A nasally administrated reactive oxygen species-responsive carrier-free gene delivery nanosystem for Alzheimer's disease combination therapy
Authors: Yongke Chen, Xiaotong Yang, Jie Li, Hang Luo, Qianqian Huang, Wenqing Yang, Ting Lei, Su Lui, Qiyong Gong, Hanmei Li, Haoxing Wu, Huile Gao
Journal: Journal of Controlled Release (2025)
Post-gastric endoscopic submucosal dissection suturing by the reopenable clip over line method using the clip with line pulley securing technique
Authors: Hiroki Kato, Makoto Kobayashi, Hirotaka Takeshima, Hiroshi Nakayabu, Akihiro Maruyama, Shintaro Tominaga, Hitoshi Sugiyama
Journal: Endoscopy (2025)

Bleeding post-endoscopic submucosal dissection (ESD) is a significant challenge. Various techniques have been developed to reduce the risk of post-ESD bleeding, one of which is the reopenable clip over line method (ROLM) reported by Nomura and colleagues, which is designed specifically to prevent hemorrhage following ESD procedures [1]. Although a final thread stopper is not always necessary in ROLM, securing the thread may enhance the stability of the suture. The locking-clip technique described by this groups achieves both thread closure and cutting simultaneously [2], but it requires a certain level of familiarity to ensure a successful outcome.
Early postoperative conjunctival complications leading to exposure of surgically implanted CorNeat EverPatch devices
Authors: Jacob Kanter, Atul Garkal, Nur Cardakli, Ian Pitha, Jasdeep Sabharwal, Oliver D Schein, Pradeep Y Ramulu, Kunal S Parikh, Thomas V Johnson
Journal: Ophthalmology (2025)

To compare the early exposure and surgical revision rates between a new synthetic tissue substitute (CorNeat EverPatch) with that of human donor cornea following placement onto the scleral surface during ophthalmic surgery, and to study the biomaterial properties of the synthetic patch material. Retrospective comparison study; biomaterial analyses of new and explanted synthetic patch material. All consecutive patients who underwent ophthalmic surgery with implantation of the CorNeat EverPatch at the Wilmer Eye Institute (occurring from February to August 2024) and a comparison group who underwent ophthalmic surgery with implantation of irradiated donor cornea, matched 1:2 with patients receiving EverPatch for age, type of glaucoma, and surgeon. Retrospective review of clinical electronic medical records of patients who underwent surgery at the Wilmer Eye Institute. Materials characterization of EverPatch including morphology, surface roughness, wettability, thermal stability, elemental analysis, and physical properties. Early exposure (within 5 months of surgery) and surgical revision rates following CorNeat EverPatch or irradiated human donor cornea implantation during ophthalmic surgery. Thirty patients undergoing ophthalmic surgery in 2024 received EverPatch implantation during primary tube shunt placement (N=27), tube shunt revision (N=2), or covering of exposed suture used for scleral fixation of an intraocular lens (N=1). During the early postoperative period, the rate of EverPatch exposure was 48.3% and the rate of surgical revision was 27.9%. In case-matched control patients (N=58), the rate of patch graft exposure was 1.7% (p<0.0001) and the rate of surgical revision was 1.7% (p<0.0001). EverPatch devices were comprised of a randomly aligned fibrous mesh with an average fiber diameter of 1.36 ± 0.78 μm, surface roughness of 1.3 ± 0.1 μm, pore size of 3.7 ± 0.4 μm2, and percent porosity of 37 ± 3%. Explanted EverPatch devices demonstrated varying degrees of tissue integration with significantly increased wettability and changes in thermal stability and elemental composition. The rate of early conjunctival complications leading to exposure of the CorNeat EverPatch was higher than in cases involving irradiated human donor corneal patch grafts.
The ULS23 challenge: A baseline model and benchmark dataset for 3D universal lesion segmentation in computed tomography
Authors: M J J de Grauw, E Th Scholten, E J Smit, M J C M Rutten, M Prokop, B van Ginneken, A Hering
Journal: Medical Image Analysis (2025)

Size measurements of tumor manifestations on follow-up CT examinations are crucial for evaluating treatment outcomes in cancer patients. Efficient lesion segmentation can speed up these radiological workflows. While numerous benchmarks and challenges address lesion segmentation in specific organs like the liver, kidneys, and lungs, the larger variety of lesion types encountered in clinical practice demands a more universal approach. To address this gap, we introduced the ULS23 benchmark for 3D universal lesion segmentation in chest-abdomen-pelvis CT examinations. The ULS23 training dataset contains 38,693 lesions across this region, including challenging pancreatic, colon and bone lesions. For evaluation purposes, we curated a dataset comprising 775 lesions from 284 patients. Each of these lesions was identified as a target lesion in a clinical context, ensuring diversity and clinical relevance within this dataset. The ULS23 benchmark is publicly accessible at https://uls23.grand-challenge.org, enabling researchers worldwide to assess the performance of their segmentation methods. Furthermore, we have developed and publicly released our baseline semi-supervised 3D lesion segmentation model. This model achieved an average Dice coefficient of 0.703 ± 0.240 on the challenge test set. We invite ongoing submissions to advance the development of future ULS models.
Innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea
Authors: Gaopeng Hou, Juhee Son, Maria Florencia Gomez Castro, Takahiro Kawagishi, Xingxing Ren, Alexa N Roth, Avan Antia, Qiru Zeng, Anna L DeVeaux, Ningguo Feng, Hinissan P Kohio, Megan T Baldridge, Terence S Dermody, Shu Zhu, Siyuan Ding
Journal: Cell Host & Microbe (2025)
Transcatheter Aortic Valve Replacement Beyond Severe Aortic Stenosis
Authors: Frans J Beerkens, Gilbert H L Tang, Annapoorna S Kini, Stamatios Lerakis, George D Dangas, Roxana Mehran, Sahil Khera, Martin Goldman, Valentin Fuster, Deepak L Bhatt, John G Webb, Samin K Sharma
Journal: Journal of the American College of Cardiology (2025)
Single cell RNA-sequencing of Ewing sarcoma tumors demonstrates transcriptional heterogeneity and clonal evolution
Authors: Andrew Goodspeed, Avery Bodlak, Alexis B. Duffy, Sarah Nelson-Taylor, Naoki Oike, Timothy Porfilio, Ryota Shirai, Deandra Walker, Amy Treece, Jennifer Black, Nathan Donaldson, Carrye Cost, Tim Garrington, Brian Greffe, Sandra Luna-Fineman, Jenna Demedis, Jessica Lake, Etienne P. Danis, Michael Verneris, Daniel L. Adams, Masanori Hayashi
Journal: Clinical Cancer Research (2025)

Abstract Purpose: Ewing sarcoma (EwS) is the second most common bone cancer in children, accounting for 2% of pediatric cancer diagnoses. Patients who present with metastatic disease at the time of diagnosis have a dismal prognosis, compared to the &amp;gt;70% 5-year survival of those with localized disease. Novel therapeutic approaches that can impact metastatic disease are desperately needed, as well as a deeper understanding of the heterogeneity of EwS tumors. Experimental Design: Here, we utilized single cell RNA-sequencing to characterize the transcriptional landscape of primary EwS tumors and surrounding tumor microenvironment (TME) in a cohort of seven untreated EwS patients, as well as in circulating tumor cells (CTCs). A potential CTC therapeutic target was evaluated through immunofluorescence of fixed CTCs from a separate cohort. Results: Primary tumor samples demonstrate a heterogenous transcriptional landscape with several conserved gene expression programs, including those composed of genes related to proliferation and EWS gene targets, which were found to correlate with overall survival. Copy-number analysis identified subclonal evolution within patients prior to treatment. Analyses of the immune microenvironment reveal an immunosuppressive microenvironment with complex intercellular communication within the tumor and immune cells. Single cell RNA-sequencing and immunofluorescence of CTCs at the time of diagnosis identified TSPAN8 as a potential therapeutic target. Conclusions: EwS tumors demonstrate significant transcriptional heterogeneity as well as a complex immunosuppressive microenvironment. This work evaluates several proposed targets which would warrant further exploration as novel therapeutic strategies.
Replication stress, microcephalic primordial dwarfism, and compromised immunity in ATRIP deficient patients
Authors: Evi Duthoo, Elien Beyls, Lynn Backers, Thorkell Gudjónsson, Peiquan Huang, Leander Jonckheere, Sebastian Riemann, Bram Parton, Likun Du, Veronique Debacker, Marieke De Bruyne, Levi Hoste, Ans Baeyens, Anne Vral, Eva Van Braeckel, Jens Staal, Geert Mortier, Tessa Kerre, Qiang Pan-Hammarström, Claus S. Sørensen, Filomeen Haerynck, Kathleen B.M. Claes, Simon J. Tavernier
Journal: The Journal of Experimental Medicine (2025)

Ataxia telangiectasia and Rad3-related (ATR) kinase and its interacting protein ATRIP orchestrate the replication stress response. Homozygous splice variants in the ATRIP gene, resulting in ATRIP deficiency, were identified in two patients of independent ancestry with microcephaly, primordial dwarfism, and recurrent infections. The c.829+5G&amp;gt;T patient exhibited lymphopenia, poor vaccine responses, autoimmune features with hemolytic anemia, and neutropenia. Immunophenotyping revealed reduced CD16+/CD56dim NK cells and absent naïve T cells, MAIT cells, and iNKT cells. Lymphocytic defects were characterized by TCR oligoclonality, abnormal class switch recombination, and impaired T cell proliferation. ATRIP deficiency resulted in low-grade ATR activation but impaired CHK1 phosphorylation under genotoxic stress. ATRIP-deficient cells inadequately regulated DNA replication, leading to chromosomal instability, compromised cell cycle control, and impaired cell viability. CRISPR-SelectTIME confirmed reduced cell fitness for both variants. This study establishes ATRIP deficiency as a monogenic cause of microcephalic primordial dwarfism, highlights ATRIP’s critical role in protecting immune cells from replication stress, and offers new insights into its canonical functions.
Single-cell eQTL mapping reveals cell subtype-specific genetic control and mechanism in malignant transformation of colorectal cancer
Authors: Can Chen, Yimin Cai, Wenlong Hu, Kai Tan, Zequn Lu, Xuanyu Zhu, Ziying Liu, Chunyi He, Guangping Xu, Ruizhe Zhang, Caibo Ning, Shuheng Ruan, Jiayan Gao, Xiaojun Yang, Yongchang Wei, Xu Zhu, Xiangpan Li, Faxi Wang, Fubing Wang, Jiaoyuan Li, Meng Jin, Bin Li, Ying Zhu, Jianbo Tian, Xiaoping Miao
Journal: Cancer Discovery (2025)

Abstract Colorectal cancer (CRC) is a heterogeneous disease that develops through a stepwise accumulation, yet the underlying mechanisms at single-cell resolution remain unclear. Here, we profiled 751,531 single-cell transcriptomes, spatial transcriptomics, and snMultiomes from 142 multistage samples, revealing the cellular and molecular alterations and dynamic intercellular crosstalk during CRC development. Additionally, we created a CRC sc-eQTL map identifying 16,833 significant pairs across 28 cell subtypes, with over 76% of sc-eQTLs being cell-type-specific and fewer than 15% detectable in bulk datasets. A polygenic risk score (PRS) derived from sc-eQTLs substantially improved CRC risk prediction. We prioritized rs4794979 that is associated with an increased CRC risk (OR=1.11, P=2.04×10-12) by promoting LGALS9 expression mediated by ELK1. Elevated LGALS9 in epithelia interacts with SLC1A5 on fibroblasts, promoting transformation into cancer-associated fibroblasts (CAFs), simultaneously induces CD8+ T cells exhaustion via LGALS9-TIM3 axis, thereby facilitating CRC development. Blocking LGALS9-TIM3 axis enhanced anti-PD-1 therapy to inhibit CRC progression.
Time to tackle obesogenic environments
Authors: None The Lancet Public Health
Journal: The Lancet Public Health (2025)

March 4th is World Obesity Day, a unified day of action calling for a response to the obesity crisis. Obesity is one of the most concerning public health crises globally. According to WHO, since 1990, obesity has more than doubled in adults and quadrupled in adolescents. In 2022, 2·5 billion adults had overweight, including 890 million with obesity, and 390 million children and adolescents aged 5–19 years had overweight, including 160 million with obesity. Overweight and obesity are associated with other major chronic diseases such as type 2 diabetes, coronary heart disease, stroke, hypertension, and cancer.