tbuckley/cabot-search huggingface dataset:
Identifying criteria for narcissistic personality disorder
Authors: E Ronningstam, J Gunderson
Journal: American Journal of Psychiatry (1990)

The authors report an exploratory effort to identify useful criteria for narcissistic personality disorder. They used the semistructured Diagnostic Interview for Narcissism to assess 24 narcissistic patients and 58 others on 33 characteristics imputed to pathological narcissism. The following characteristics were significantly more common among the patients with narcissistic personality disorder: a sense of superiority, a sense of uniqueness, exaggeration of talents, boastful and pretentious behavior, grandiose fantasies, self-centered and self-referential behavior, need for attention and admiration, arrogant and haughty behavior, and high achievement. The results provide an empirical basis for developing an improved set of criteria for narcissistic personality disorder.
Quality assurance monitoring in psychiatry
Authors: M A Fauman
Journal: American Journal of Psychiatry (1989)

The implementation of quality assurance monitoring is an important response to public demands for accountability in medicine as well as a requirement for institutional accreditation by the Joint Commission on Accreditation of Healthcare Organizations (JCAHO). The author examines the somewhat elusive definition of quality as it is applied to medical care. He reviews the history, terminology, and reasons for quality assurance monitoring and presents the JCAHO-defined concepts of indicators and thresholds. Several common problems associated with the implementation of quality assurance monitoring are discussed along with guidelines for the development of quality assurance indicators in psychiatry.
Abstract 11010: Serum Sphingolipids Level as a Novel Potential Indicator for Early Detection of Cardiac Ischemia
Authors: Emmanuel Eroume A Egom, Mamas A Mamas, Sanoj Chacko, Sally E Stringer, Valentine Charlton-Menys, Magdi El-Omar, Debora Chirico, Bernard Clarke, Ludwig Neyses, Kennedy J Cruickshank, Ming Lei, Farzin Fath-Ordoubadi
Journal: Circulation (2010)

Objectives: We tested the hypothesis that sphingolipid concentrations would increase sharply after even transient cardiac ischemia following temporary coronary artery occlusion during percutaneous ...
A Doctor's Diary in Damaraland.
Authors: Henry Francis Bell Walker
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical correlates of lateral ventricular enlargement in bipolar affective disorder
Authors: G. D. Pearlson, D. J. Garbacz, R. H. Tompkins, H. S. Ahn, D. F. Gutterman, A. E. Veroff, J. R. Depaulo
Journal: American Journal of Psychiatry (1984)

The presence of lateral ventricular enlargement in some manic-depressive subjects, as assessed by ventricular-brain ratios (VBRs), has been reported. A study of 27 bipolar patients and 27 individually matched normal controls confirmed that finding. Bipolar patients had significantly larger VBRs than did controls. Clinical measures associated with the presence of ventricular enlargement in the bipolar patients included more frequent hospitalizations and histories of persistent unemployment. Other measures of illness severity or social deterioration were not significantly associated with large VBR.
Methylation profile of human breast cancer: A possible biomarker for the detection of circulating tumor cells
Authors: D. M. Marzese, F. E. Gago, L. M. Vargas-Roig, M. Roqué
Journal: Journal of Clinical Oncology (2009)

11112 Background: Genetic and epigenetic events are complementary mechanisms involved in breast carcinogenesis. One of the most common epigenetic mechanisms by which genes are silenced is the aberrant methylation of their promoter CpG islands, i.e. hypermethylation in promoters of Tumor Suppressor Genes. The identification of circulating tumor cells (CTCs) in the blood of cancer patients, based on their aberrant methylation profile, appears as a potential tool for early detection and provides therefore the promise of a non-invasive and affordable cancer detection test. Methods: The methylation status of 26 cancer-related regions was studied, using Methyl Specific-Multiplex Ligation dependent Probe Amplification (MS-MLPA) assay in invasive breast tumors (n=24), axillary lymph nodes (n= 5), and normal breast tissue (n=2). A nested-Methyl Specific PCR (Nested-MSP) was designed for one of the methylated regions in the tumor suppressor gene rassf1A, to identify CTCs in peripheral blood samples. Blood samples from non tumor individuals were used as control. Results: We observed aberrant methylation of one or more of the 26 studied gene regions in all the breast cancer samples. The profiles were specific for each tumor. The more frequently aberrant methylated genes were: rassf1A promoter (62.5%), esr1 (54.17%), apc (54.17%) and rassf1A exon 1 (50%). Absence of aberrant methylation was confirmed in normal breast tissues. The specific methylation profile of tumors could be used to identify the metastasis origin in a patient with a left-sided breast tumor and bilateral tumor invasion of axillary lymph nodes. MS-MLPA revealed identical aberrant methylation patterns in both lymph nodes, revealing a left-sided origin of the right-sided lymph node. For the detection of CTCs in blood, a Nested-MSP on rassf1A was designed. This method allowed the detection of CTCs in the peripheral blood of a cancer patient by their aberrant rassf1A methylation. A healthy age-matched control blood sample revealed absence of CTCs. Conclusions: The identification of the methylation profile of the tumor by MS-MLPA allowed to establish the metastasis origin of invaded axillary lymph nodes and to detect CTCs in peripheral blood of a cancer patient. No significant financial relationships to disclose.
Human immunodeficiency virus-associated Hodgkin's disease derives from post-germinal center B cells.
Authors: Antonino Carbone, Annunziata Gloghini, Luigi M. Larocca, Andrea Antinori, Brunangelo Falini, Umberto Tirelli, Riccardo Dalla-Favera, Gianluca Gaidano
Journal: Blood (1999)
Diseases of Lymphatics and Lymph Circulation.
Authors: Mihály Földi
Journal: Annals of Internal Medicine (1969)

The neglected lymphatics have found a champion. This unique monograph represents the significant efforts of Professor Foldi to gain recognition for his step-child science. It is comprehensive, clinically oriented, liberally illustrated, and written with clarity. Most of the references are European, but that is understandable; for some reason the invisible network has not intrigued American investigators.
Abstract 17917: Is Small Change Significant? Association of Small Differences in Life's Simple 7 and Mortality: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort
Authors: Mary Cushman, Suzanne E Judd, Virginia J Howard, Neil A Zakai, Brett Kissela, Dawn Kleindorfer, Monika M Safford, George Howard
Journal: Circulation (2011)

Background. The AHA 2020 Goal includes improving cardiovascular health, defined using a metric consisting of 7 health factors, Life's Simple 7. A central concept of the goal is that small improvements in behavior / lifestyle factors at the population level will lead to large risk reductions over the life course. We developed a simple score to quantify Life's Simple 7 and evaluated the association of small differences in this score with all-cause mortality in REGARDS, a biracial national cohort. Methods. We studied 17,820 REGARDS participants without vascular diseases; black and white men and women aged 45-98 from across the US, enrolled in 2003-7, when extensive risk factor data were measured in participants' homes. The 7 components of Life's Simple 7 (blood pressure, cholesterol, glucose, BMI, smoking, physical activity, diet) were each scored in AHA-defined categories of poor (1 point), intermediate (2 points) and ideal (3 points), and were summed to yield scores ranging from poor for all (7) to ideal for all (21). With 4.6 years follow up there were 2319 deaths. Results. The score was normally distributed with mean (SD) of 13.5 (2.6). The age, sex and race-hazard ratio (HR) of death for a 1-unit increase in Simple 7 Score was 0.86 (95% CI 0.84, 0.87). There was no impact of further adjustment for income and education. Considering only the 4 behavior/lifestyle score components (BMI, smoking, physical activity, diet), the adjusted HR per 1 unit higher score was 0.79 (95% CI 0.77, 0.81). Conclusions. A small incremental difference, corresponding to improvement of 1 category (poor to intermediate or intermediate to ideal) for 1 component of Life's Simple 7 Score was associated with substantial reduction in 4.6-year all cause mortality. The association was larger considering only the 4 behavioral/lifestyle components. Results suggest profound implications of achieving the 2020 Goal that 20% of people improve by 1 level of this metric.
Abstract 2459: A Potentially Novel Role Of The Follistatin-activin Pathway In Heart Failure And Myocardial Recovery Following Lvad Combination Therapy
Authors: Enrique Lara-Pezzi, Leanne E Felkin, Padmini Sarathchandra, Robert George, Jennifer L Hall, Magdi H Yacoub, Nadia Rosenthal, Emma J Birks, Paul J Barton
Journal: Circulation (2007)

Background - Recent evidence suggests that the activin pathway may play an important role in the pathogenesis of heart failure. Follistatins are potent inhibitors of activin signalling but their role in the heart is unknown. The purpose of this study was to investigate myocardial expression of follistatin (FST) and follistatin-like (FSTL1 and FSTL3) in heart failure and following recovery in patients who received combined mechanical unloading using left ventricular assist device (LVAD) and pharmacologic therapy. Methods and results - Real time quantitative PCR was used to examine gene expression in myocardial samples from donors (n=9), end-stage heart failure patients (n=27) and patients who recovered from heart failure sampled at the time of LVAD implant, at the time of LVAD removal following recovery, and one year post explant. Both FSTL1 and FSTL3 were elevated in heart failure (1.51 and 2.50 fold respectively p&lt;0.005) with expression returning to normal following recovery. Whereas FSTL3 correlated with molecular markers of disease severity, FSTL1 showed negative correlation with skeletal α-actin and positive correlation with the endothelial cell marker CD31, suggesting a potential link with extent of vascularization. FSTL1 expression levels at LVAD implant also correlated with significantly higher ejection fraction following recovery suggesting initial levels may have an influence on long term outcome. Immunohistochemical analysis showed that FST was localised in fibroblasts and endothelium, FSTL1 in myocytes, endothelium and smooth muscle cells, and FSLT3 in myocytes and endothelium. Microarray analysis showed that FST and FSTL1 expression correlate with extracellular matrix-related and calcium binding proteins, whereas FSTL3 is associated with cell signalling and transcription. Conclusion - These data show for the first time that elevated myocardial expression of follistatin-like genes is a feature of heart failure and that this may be linked both to disease severity and to mechanisms underlying recovery thereby revealing new insight into the pathogenesis of heart failure and offering novel therapeutic targets.
An Introduction to Practical Bacteriology As Applied to Medicine and Public Health. A Guide to Bacteriological Laboratory Work for Students and Practitioners of Medicine.
Authors: T. J. Mackie, J. E. McCartney
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12668: Platelet Pharmacogenetics in Common Clinical Practice
Authors: Jeffrey J Verschuren, Helen Boden, Judith A Wessels, Henk-Jan Guchelaar, Martin J Schalij, J Wouter Jukema
Journal: Circulation (2011)

Purpose:  Antiplatelet drug resistance is a well known problem, causing recurrent cardiovascular events despite adequate guideline therapy. The role of pharmacogenetics has been demonstrated in several large trials reporting polymorphisms related to antiplatelet resistance. However, the influence of these polymorphisms in unselected populations in clinical practice remains to be elucidated. We investigated the best replicated polymorphisms in an unselected population of patients presenting with acute myocardial infarction (AMI).   Methods:  Patients with AMI (n=1287) presenting in the Leiden University Medical Center between 2004 and 2010 were treated according to the standardized guideline-based MISSION protocol. All patients underwent a primary PCI. Aspirin and clopidogrel were prescribed to 94% and 98% of the patients respectively. Cardiovascular events (AMI, revascularization or cardiac death) were recorded during the first year after the index event. The selected genetic polymorphisms, COX-1 (-842A>G), P2Y1 (893C>T), GP Ia (807C>T), GP IIIa (PlA1/A2), CYP2C19 (*2, *3 and *17) and ABCB1 (3435T>C), were genotyped using MassArray platform (Sequenom). Associations were tested with a Cox regression model with adjustment for known risk factors.   Results:  During follow up, 246 patients (19.1%) suffered from a cardiovascular event. Patients homozygous for the CYP2C19*2 allele had an increased risk of an event, HR 1.91 (95% CI 1.49-2.44), p=3.8x10-7. To a lesser extent, also carriers of the GPIIIa PlA2/A2 genotype were at risk, HR 1.38 (1.02-1.88), p=0.037. The other polymorphisms were not associated with treatment outcome.   Conclusion:  We demonstrate that in an unselected all-comers population of AMI patients the CYP2C19*2 allele is associated with an increased risk of cardiovascular events. Testing for this polymorphism might prove useful in identification of patients that could benefit from more potent antiplatelet therapy.
Practical Materia Medica and Prescription Writing.
Authors: Oscar Walter Bethea
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison Of R-CHOP14 and R-CHOEP14 As First Line Treatment In Young Patients With High-Risk (aaIPI 2-3) Diffuse Large B-Cell Lymphoma (DLBCL): A Joint Analysis Of Two Prospective Phase III Randomized Trials Conducted By The Fondazione Italiana Linfomi (FIL) and The German High-Grade Lymphoma Study Group (DSHNHL)
Authors: Umberto Vitolo, Marita Ziepert, Bertram Glass, Bettina Altmann, Annalisa Chiappella, Andrea Evangelista, Giovannino Ciccone, Pier Luigi Zinzani, Maike Nickelsen, Markus Loeffler, Maurizio Martelli, Norbert Schmitz
Journal: Blood (2013)
Polymorphisms In IRS1 and IL6R and Susceptibility To Multiple Myeloma
Authors: Brenda M. Birmann, Kristin A Rand, David V. Conti, David J. Van Den Berg, Christopher A. Haiman, Anneclaire J. De Roos, Richard K Severson, Christopher K. Edlund, Sikander Ailawadi, Mulugeta Gebregziabher, Ann M Mohrbacher, Michael R Lieber, Sophia S. Wang, Leslie Bernstein, Brian E. Henderson, Nathaniel Rothman, Stephen Jacob Chanock, Laurence N. Kolonel, Graham A. Colditz, Nikhil C. Munshi, Kenneth C. Anderson, Wendy Cozen
Journal: Blood (2013)
Screening for Type 2 Diabetes Mellitus in Adults: U.S. Preventive Services Task Force Recommendation Statement
Authors: Ned Calonge, Diana B. Petitti, Thomas G. DeWitt, Allen J. Dietrich, Leon Gordis, Kimberly D. Gregory, Russell Harris, George Isham, Rosanne Leipzig, Michael L. LeFevre, Carol Loveland-Cherry, Lucy N. Marion, Virginia A. Moyer, Judith K. Ockene, George F. Sawaya, Barbara P. Yawn
Journal: Annals of Internal Medicine (2008)

Description: Updated U.S. Preventive Services Task Force (USPSTF) recommendation about screening for type 2 diabetes mellitus in adults. Methods: To estimate the balance of benefits and harms of screening, the USPSTF updated its 2003 evidence review, adding evidence from new trials as well as updates on earlier studies. The review for this current recommendation focused on evidence that early treatment prevented long-term adverse outcomes of diabetes, including cardiovascular events, visual impairment, renal failure, and amputation. Recommendations: Screen for type 2 diabetes in asymptomatic adults with sustained blood pressure (either treated or untreated) greater than 135/80 mm Hg. (B recommendation) Current evidence is insufficient to assess the balance of benefits and harms of routine screening in asymptomatic adults with blood pressure of 135/80 mm Hg or lower. (I statement)
THE TRADE OF MEDICINE
Authors: Paul Popovici, Ovidiu Chiroban
Journal: BMJ (1907)

Is there a link between trade and medicine? As origins, commercial interests were foreign from the medical tradition; in other words, the answer would be negative. From this point of view, the differences between a hospital and a commercial enterprise should be more than obvious. It will therefore be very important to note the differences between a doctor from a trader, a patient from a customer, and eventually the patient from the merchandise. Is medicine a business? Although the answer is negative in theory, in practice we can find answers in formal terms that are positive (unfavorable but by implication). In fact, this is a tribute paid to a number of shortcomings: from the lack of a vocational education to the anemic reaction of various institutions with a precise role in this direction.
Abstract 18729: Serum Heat Shock Protein-70 is Associated With Decreased Frequency and Severity of Cellular Rejection in Cardiac Transplant Patients
Authors: Hatem Al Kassem, Danny J Eapen, Pankaj Manocha, Divya Gupta, Jenna Kay, Malik Obideen, Michael M Halista, Sarah S Kabani, Adil Niaz, Saket Kumar, Wendy Book, Sergey Sikora, Laurence Sperling, Arshed Quyyumi
Journal: Circulation (2012)

Background: Heat Shock Protein-70 (HSP70) is a highly conserved intracellular protein that is up-regulated in cells undergoing stressful stimuli. A recent study demonstrated an inverse relationship between HSP70 expression and cellular rejection grade in endomyocardial biopsies (EBx)from cardiac transplant patients. Peripheral blood based HSP70 levels have not been studied in such individuals. We hypothesized that serum HSP70 levels will be associated with severity of cellular rejection in cardiac transplant patients. Methods: 177 cardiac transplant patients (56 ± 13 years; 8.5 ± 5 years mean time from transplant) were recruited from the Emory Cardiovascular Biobank from 2004-2012. Cellular rejection was defined based on revised International Society of Heart and Lung Transplant (ISHLT) grade of 1R or higher seen on EBx. Frequency of rejection was collected from time of transplant to enrollment date. Serum HSP70 was measured using ELISA and analyzed as detectable vs non-detectable. Nonparametric correlations and ANOVA were used to study univariate relationships while linear and ordinal logistic regression (adjusted for age, gender, race, length of time since transplant, and immunosuppressant medications) were performed to analyze the relationship between HSP70 levels and frequency and severity of cellular rejection respectively. Results: HSP70 was detectable in 35% of patients with grade 0R ISHLT class, 33% for grade 1R, 16% for Grade 2R, 0% for Grade 3R (p for group=0.005). There was an inverse correlation between HSP70 and frequency of rejection (r= -0.2, p= 0.03) with 34% of those with detectable HSP70 in the lowest quintile based on frequency of rejection whereas 9% was detected in the highest quintile (p=0.019). In adjusted regression models, HSP70 remained a significant independent predictor of a) ISHLT class with an OR of 0.43 (p=0.02) and b) frequency of rejection (β=-1.5, p=0.05). Conclusion: Detectable serum HSP70 is associated with decreased frequency and severity of cellular rejection in post cardiac transplant patients. The utility of HSP70 as a marker of graft function needs further study.