tbuckley/cabot-search huggingface dataset:
Abstract P272: Leg Strength and Gait Speed Predict Enrollment in an Exercise Study among Stroke Survivors with Mild-Moderate Disability
Authors: Mallory L Keller, Ruth E Taylor-Piliae
Journal: Circulation (2012)

Background: Stroke is the third leading cause of death in the United States and is the major contributor to physical and cognitive disability among this population. Exercise is an important aspect of stroke rehabilitation to reduce disability. Objective: To determine if functional disability, physical function, cognitive impairment, age or gender are predictive of enrollment in an exercise study among stroke survivors with mild-moderate disability. Methods: Cross-sectional design using data from stroke survivors (n=166) that consented to be screened for an exercise study, the “Tai Chi for Stroke Survivors Study.” All subjects completed a brief survey to determine eligibility, prior to screening. Screening tests included the Modified Rankin Scale (mRS, functional disability), Short Physical Performance Battery (SPPB, physical function), and Mini-Mental Status Exam (MMSE, cognitive function). First, we conducted bivariate logistic regression using mRS, SPPB-balance, gait speed and leg strength test times, MMSE, age and gender, as single predictors of study enrollment. Then, we conducted multiple logistic regression using significant predictors to determine the overall model. Results: Subjects (n=166) were on average 69±11 years old, and reported mild-moderate disability (mRS=2.0±0.8), had some impairments in physical functioning (SPPB=7.0±2.6), diminished leg strength (5-timed chair stands=19.3±7.2 seconds), and slow gait speed (0.76±0.3 meters/second) but, were without cognitive impairments (MMSE=27.8±3.3). Significant predictors of study enrollment were leg strength [X 2 (1)=16.37, p&lt;0.01] and gait speed [X 2 (1)=6.89, p&lt;0.01]. Multiple logistic regression indicated that leg strength and gait speed together were predictive of enrollment [X 2 (2)=22.38, p&lt;0.01]. Prediction success was 77% overall. Leg strength was a significant predictor in the model (Wald=6.2, p=0.01), indicating that as test completion time increases, the odds of enrollment increases [Exp(B)=1.12, CI=1.03–1.23]. Gait speed was a significant predictor in the model (Wald=5.6, p=0.02), indicating that as gait speed increases, the odds of enrollment decreases [Exp(B)=0.14, CI=0.03–0.71]. A total of 60% (100/166) of screened subjects (women=46/100) enrolled in our study. Conclusion: Physical function has been shown to predict disability and overall decline in health and well-being in stroke survivors with mild-moderate disability. The SPPB is simple to administer, taking 5–10 minutes to complete. This test readily identified stroke survivors with diminished leg strength and slower gait speed, and was predictive of enrollment in our exercise study.
An Investigation of the Salmonella Group, with Special Reference to Food Poisoning.
Authors: William G. Savage, Philip Bruce White
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1072: Home Blood Pressure Monitoring Provides Important Prognostic Information in Patients Treated With a Cardiac Resynchronization Therapy Defibrillator
Authors: John P Boehmer, John Day, Francis R Gilliam, Paul A Heidenreich, David L Hayes, Milan Seth, Paul W Jones, Timothy E Meyer, Leslie A Saxon
Journal: Circulation (2009)

Background: Hypertension is a common morbidity prior to the onset of heart failure (HF). Patients with systolic HF often have low BP, and lower SBP is a poor prognostic indicator. We evaluated a la...
Nucleotide excision repair polymorphisms modulate overall lung cancer survival and responsiveness to platinum based chemotherapy agents
Authors: A. Matakidou, T. Eisen, H. Bridle, R. S. Houlston
Journal: Journal of Clinical Oncology (2006)

10004 Background: The role of DNA repair in maintaining genomic stability and its role in modulating response to chemotherapy agents raises the possibility that variation in these genes may affect lung cancer prognosis. Methods: To comprehensively evaluate the impact of variation in the nucleotide excision repair (NER) pathway on lung cancer prognosis, we analysed 408 lung cancer patients for all coding, non-synonymous single nucleotide polymorphisms (SNPs) within NER-related genes. Results: Mean age of lung cancer diagnosis among patients was 63 years, 105 patients with small cell lung cancer (SCLC) and 299 with non-small cell lung cancer (NSCLC). The mean follow-up time was 24 months and a total of 234 deaths were observed. Mean survival time was 17.3 and 18.6 months for SCLC and NSCLC respectively. The XPG H1104D minor allele homozygote and the tightly linked CSB M1097V, R1213G, and Q1413R heterozygote genotypes were associated with decreased overall survival, irrespective of whether patients were treated with or without platinum chemotherapy (HRs of 2.22, 95% CI: 1.19–4.16; p=0.013 and 1.39, 95% CI: 1.05–1.84; p=0.02 respectively). No statistically significant interaction was detected between the at-risk genotypes and histology and/or stage of disease at diagnosis. To assess the predictive value of these SNPs in relation to platinum based chemotherapy, genotype-survival associations were evaluated in non-platinum and platinum treated patients. In non-platinum treated patients the RAD23B A249V and CSB M1097V minor allele genotypes were associated with decreased overall survival (p=0.004 and 0.002 respectively), whilst the XPC K939Q minor allele genotype was predictive of improved survival (p=0.03). In platinum-treated patients, carriers of the XPG H1104D minor allele were found to have a statistically significant decrease in their overall survival (p=0.04 and 0.004 for minor allele heterozygote and homozygote patients respectively). Conclusions: These findings suggest that genetic polymorphisms in the NER genes may modulate overall lung cancer prognosis as well as response to platinum-based chemotherapy agents, independent of histological diagnosis and stage of disease at presentation. No significant financial relationships to disclose.
Die physikalischen Grundlagen des Betriebes von Röntgenröhren mit dem Induktorium.
Authors: P. Ludewig
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PREVENTING DRINK-DRIVING
Authors: D Gloag
Journal: BMJ (1990)

This very short article describes a new type of vehicle breath monitor which features in a law introduced this month in Australia. It is an accurate microcomputer controlled breath alcohol tester that is linked to a vehicle's ignition to act as a motor interlock device. If the driver's breath alcohol concentration is over the legal limit the engine cannot be started. Such devices can also require a series of breath samples to keep ignition in operation. This is to cater for the fact that breath alcohol concentration may rise after the driver has started his car and driven away. Systems are included to prevent the driver from evading or tampering with the monitor. The new law introduced in Victoria for a trial period states that convicted drivers may be offered the device for a probationary 2 years before review instead of a continued ban on driving. They must however lose their licences for an initial period. The blood alcohol concentration limit permitted by the device will usually be 20 mg/100 ml, but those convicted of driving with a concentration greater than 100 mg/100 ml will be offered a device set at zero for a probationary 3 years. The device may also be used in 16 American States.
Retraining Canada's Disabled Soldiers.
Authors: Walter E. Segsworth
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2835: Same-Day Discharge can be Achieved Safely in the Majority of Patients Undergoing Percutaneous Coronary Intervention for High Risk Lesions
Authors: Anil M Ranchord, Thomas W Mitchell, Sandhir Prasad, Sujith K Seneviratne, Russell Anscombe, Mark B Simmonds, Phillip P Matsis, Andrew Aitken, Scott A Harding
Journal: Circulation (2006)

Introduction: The majority of day-case percutaneous coronary intervention (PCI) programs exclude patients with high risk lesions. We investigated whether day-case PCI can safely be expanded to incl...
Abstract 17116: Influence of Adherence Monitoring Program on Long-Term Platelet Inhibition by Clopidogrel: Results of a Randomized Controlled Trial
Authors: Valentina Forni Ogna, Gregoire Wuerzner, Isabelle Menetrey, Linda Guihard, Eric Tousset, Olivier Muller, Pierre Fontana, Eric Eeckhout, Michel Burnier
Journal: Circulation (2012)

Introduction: Oral P2Y12 antagonist clopidogrel is the mainstay of platelets inhibition treatment after percutaneous coronary intervention (PCI). However, there is strong evidence that the biologic...
Abstract 056: Normative Accelerometer-determined Steps/day from 6-85 Years of Age: NHANES 2005-2006
Authors: Catrine Tudor-Locke, John M Schuna, Tiago V Barreira, Emily F Mire, Stephanie T Broyles, Peter T Katzmarzyk, William D Johnson
Journal: Circulation (2013)

Introduction: Reference values used to interpret objectively monitored ambulatory activity (steps/day) represent summarized data collected with different instruments and protocols and aggregated across typically small, select, and disparate samples (e.g., sex composition and age groupings). A full distribution of nationally representative normative data presented by sex-age year collected using a single instrument and a standardized protocol is preferred. The purpose of this analysis of the 2005-2006 National Health and Nutrition Examination Survey (NHANES) accelerometer data is to provide smoothed (i.e., using LMS curve analyses) sex-age rankings from 6-85 years of age. Hypothesis: We hypothesized that, across the lifespan, accelerometer-determined steps/day would be 1) higher in males than females; and 2) lower with higher ages. Methods: Objectively monitored steps/day were measured using the ActiGraph accelerometer (model 7164) worn for 7 consecutive days. The analysis sample was comprised of 6,354 (51.8% female) individuals with valid accelerometer data (≤1 days with ≤10 monitored hours). Percentile values (25 th , 50 th , 75 th , 95 th ) were computed for each single-year age by sex using the LMS method (LMS Chartmaker Pro Version 2.3). To avoid artificially creating sex/age differences through modeling procedures, the L, M and S parameters were chosen using the entire sample then applied to males and females separately to create the curves. Apparent differences by sex and age were noted. Results: LMS curves for steps/day percentile values are presented in the Figure. Steps/day were higher for males than females at every age. A distinct pattern of incrementally reduced steps/day was apparent with higher age across the lifespan. Conclusions: Sex and age are apparent modifiers of steps/day. These normative accelerometer-determined steps/day values can be used for multiple purposes including screening, program development and evaluation, comparison between populations, and tracking change.
Stage and histology influence the relationship between MDM2 promoter polymorphism and esophageal cancer and overall survival (OS)
Authors: H. J. Mackay, P. Bradbury, K. Asomaning, W. Zhou, M. Kulke, L. Su, R. Suk Heist, T. J. Lynch, D. C. Christiani, G. Liu
Journal: Journal of Clinical Oncology (2007)

21047 Background: A single nucleotide polymorphism in the MDM2 promoter (SNP309) has been found to affect OS of advanced stage gastric adenocarcinoma (AD) and early stage squamous (SQ) cell carcinoma of the lung. The aim of this study was to evaluate the role of this polymorphism in the prognosis of esophageal cancer, another aerodigestive cancer. Methods: 150 early stage (E) and 118 locally advanced stage (LA) esophageal cancers were genotyped for MDM2 SNP309 using Taqman. The primary endpoint was overall survival (OS). Results: E disease: n=23 stage I; n=127 stage II. LA disease: n=93, Stage III; n=25, Stage IVA. AD comprised 215 (81%), while SQ comprised 45 (17%) of cases; 8 (3%) had poorly differentiated tumors. Median follow-up = 32 months. Median OS were 36 and 21 months for E and LA disease, respectively. Both histology and disease stage affected the relationship between SNP309 and esophageal cancer OS (see Table ). The wildtype T/T genotype conferred a worse OS in E patients (log-rank, p=0.03), especially those with AD (log-rank, p=0.003). In Cox proportional hazards interaction analyses, after adjusting for age, gender, stage and PS, there were statistically significant interactions between MDM2 SNP309 and disease stage (interaction p=0.004) and between MDM2 SNP309 and histologic subtype (AD vs. SQ)(interaction p=0.02). Thus, the direction of SNP309 association from our AD and E esophageal cancer patients are opposite to those of our SQ and LA esophageal cancer patients. However, our SQ and LA results are similar to the SQ lung cancer and advanced stage gastric cancers previously reported. This suggests that biologic mechanisms underpinning the prognostic role of SNP309 are dependent on extent of disease and histologic subtype. Conclusion: Histology and disease stage interact with the prognostic role of MDM2 SNP309 polymorphism in esophageal cancer OS. [Table: see text] No significant financial relationships to disclose.
Pneumocoques et Affections Pneumococciques.
Authors: L. Cotoni, C. Truche, A. Raphael
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 16658: Greater Post-Aspirin Residual Platelet Aggregation is Associated With Increased Risk of Incident Acute Coronary Syndromes in Healthy Individuals
Authors: Rehan Qayyum, Brian G Kral, Lisa R Yanek, Dhananjay Vaidya, Paul A Nyquist, Rasika Mathias, Lewis C Becker, Diane M Becker
Journal: Circulation (2011)

Background: Platelet aggregation plays an essential role in the pathogenesis of acute coronary syndrome (ACS). Aspirin (ASA), as an inhibitor of the cyclooxygenase-1 (COX-1) and thromboxane-dependent platelet activation pathways, is the mainstay of primary chemoprophylaxis. However, studies have demonstrated that persons still experience an ACS event while on ASA, suggesting that variation in indirect COX-1 pathways may contribute to clinical outcomes. We determined the extent to which an increased risk of incident ACS would be observed in healthy individuals with residual platelet aggregation in an important indirect COX-1 pathway following ASA. Methods: 1507 apparently healthy individuals with a family history of premature coronary artery disease were enrolled for 2-week therapy with of ASA 81 mg/day. At the end of second week, whole blood impedance aggregometry after collagen-mediated (5ug/mL) platelet aggregation was used to measure maximal platelet aggregation. ACS events during follow-up were adjudicated from medical records by 3 independent reviewers. Results: At baseline, the mean (SD) age was 46.3 (11.5) years; 57% female; 37% African American; 23% current smokers, 34% hypertensive, and 8% diabetes. During follow-up (mean 5[1.8] years), there were 26 ACS events. Post-ASA residual collagen-mediated platelet aggregation was greater in participants who had an ACS compared with those without ACS (28.5 ohms vs. 24.0 ohms, p&lt;0.001). In an age, sex, race, and cardiovascular risk factors (LDL cholesterol, current smoking, diabetes, and hypertension) adjusted model, one ohm difference in residual collagen-mediated platelet aggregation was strongly associated with a 7% increase in the hazard of an ACS event (HR = 1.07, 95%CI = 1.02 to 1.11, p = 0.002). Conclusions: Healthy subjects with greater residual collagen-mediated platelet aggregation in an indirect COX-1 pathway after ASA therapy are at significantly higher risk of ACS than subjects with lower aggregation. Platelet aggregation pathways not directly inhibited by ASA may play an important role in the pathogenesis of ACS.
Limited Binding Capacity Sites for l-Triiodothyronine in Rat Liver Nuclei
Authors: Jack H. Oppenheimer, Harold L. Schwartz, Diona Koerner, Martin I. Surks
Journal: Journal of Clinical Investigation (1974)

Further studies have been performed to define the kinetic characteristics of nuclear triiodothyronine (T3) binding sites in rat liver (J. Clin. Endocrinol. Metab. 1972. 35: 330). Sequential determination of labeled T3 associated with nuclei and cytoplasm over a 4-h period allowed analysis of the relationship of T3 in nuclear and cytoplasmic compartments. A rapid interchange of hormone between nuclei and cytoplasm was demonstrated, and in vitro incubation experiments with nuclei yielded no evidence favoring metabolic transformation of T3 by the nuclei. In vivo displacement experiments were performed by subcellular fractionation of liver ½ h after injection of [125I]T3 with increasing quantities of unlabeled T3. The nuclear binding capacity for T3 could be defined (0.52 ng/mg DNA). Analysis of these experiments also allowed an estimation of the association constant of nuclear sites for T3 (4.7 × 1011M−1). The affinity of these sites for T3 was estimated to be 20-40 fold greater than for thyroxine (T4). Chromatographic analysis of the nuclear radioactivity after injection of labeled T4 indicated that the binding of T4 by the nucleus could not be attributed to in vivo conversion of T4 to T3 but reflected intrinsic cross-reactivity of the two iodothyronines at the nuclear binding sites.
Premature interruption of psychotherapy: continuation of contact by telephone and correspondence
Authors: M Rosenbaum
Journal: American Journal of Psychiatry (1977)

The author collected data on 15 patients for whom therapy was interrupted because of a move to a distant city by the analyst or the patient. He found that 14 of these patients refused to accept transfer to another analyst as urged by their analyst; instead, they continued contact by phone and/or correspondence with the analyst for long periods of time. Continuation of contact was not related to diagnosis but perhaps to a basic inability of these patients to face and work through separation or to some type of special patient-therapist relationship.
The Care and Treatment of European Children in the Tropics.
Authors: G. Montagu Harston, Manson, Patrick, Sir
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal