tbuckley/cabot-search huggingface dataset:
To warrant clinical adoption AI models require a multi-faceted implementation evaluation
Authors: Davy van de Sande, Eline Fung Fen Chung, Jacobien Oosterhoff, Jasper van Bommel, Diederik Gommers, Michel E. van Genderen
Journal: npj Digital Medicine (2024)

Abstract Despite artificial intelligence (AI) technology progresses at unprecedented rate, our ability to translate these advancements into clinical value and adoption at the bedside remains comparatively limited. This paper reviews the current use of implementation outcomes in randomized controlled trials evaluating AI-based clinical decision support and found limited adoption. To advance trust and clinical adoption of AI, there is a need to bridge the gap between traditional quantitative metrics and implementation outcomes to better grasp the reasons behind the success or failure of AI systems and improve their translation into clinical value.
The STROCSS 2024 guideline: strengthening the reporting of cohort, cross-sectional, and case–control studies in surgery
Authors: Rasha Rashid, Catrin Sohrabi, Ahmed Kerwan, Thomas Franchi, Ginimol Mathew, Maria Nicola, Riaz A. Agha
Journal: International Journal of Surgery (2024)

Introduction: First released in 2017, the STROCSS guidelines have become integral for promoting high-quality reporting of observational research in surgery. However, regular updates are essential to ensure they remain relevant and of value to surgeons. Building on the 2021 updates, we have developed the STROCSS 2024 guidelines. This timely revision aims to address residual reporting gaps, assimilate recent advances, and further strengthen observational study quality across all surgical disciplines. Methods: A core steering committee compiled proposed changes to update the STROCSS 2021 guidelines based on identified gaps in prior iterations. An expert panel of surgical research leaders then evaluated the proposed changes for inclusion. A Delphi consensus exercise was used. Proposals that scored between 7-9 on a nine-point Likert agreement scale, by ≥70% of Delphi participants, were integrated into the STROCSS 2024 checklist. Results: In total, 46 of 56 invited participants (82%) completed the Delphi survey and hence participated in the development of STROCSS 2024. All suggested amendments met the criteria for inclusion, indicating a high level of agreement among the Delphi group. All proposed items were therefore integrated into the final revised checklist. Conclusion: We present the updated STROCSS 2024 guidelines, which have been developed through expert consensus to further enhance the transparency and reporting quality of observational research in surgery.
Translational adaptation in breast cancer metastasis and emerging therapeutic opportunities
Authors: Siyu Chen, Albertas Navickas, Hani Goodarzi
Journal: Trends in Pharmacological Sciences (2024)

Breast cancer's tendency to metastasize poses a critical barrier to effective treatment, making it a leading cause of mortality among women worldwide. A growing body of evidence is showing that translational adaptation is emerging as a key mechanism enabling cancer cells to thrive in the dynamic tumor microenvironment (TME). Here, we systematically summarize how breast cancer cells utilize translational adaptation to drive metastasis, highlighting the intricate regulation by specific translation machinery and mRNA attributes such as sequences and structures, along with the involvement of tRNAs and other trans-acting RNAs. We provide an overview of the latest findings and emerging concepts in this area, discussing their potential implications for therapeutic strategies in breast cancer.
Supramolecular Heterodimer Peptides Assembly for Nanoparticles Functionalization
Authors: Clélia Mathieu, Shayamita Ghosh, Julien Draussin, Adeline Gasser, Guillaume Jacquot, Mainak Banerjee, Tanushree Gupta, Marc Schmutz, Céline Mirjolet, Olivier Tillement, François Lux, Andrey S. Klymchenko, Mariel Donzeau, Xavier Pivot, Sébastien Harlepp, Alexandre Detappe
Journal: Advanced Healthcare Materials (2024)

Nanoparticle (NP) surface functionalization with proteins, including monoclonal antibodies (mAbs), mAb fragments, and various peptides, has emerged as a promising strategy to enhance tumor targeting specificity and immune cell interaction. However, these methods often rely on complex chemistry and suffer from batch-dependent outcomes, primarily due to limited control over the protein orientation and quantity on NP surfaces. To address these challenges, a novel approach based on the supramolecular assembly of two peptides is presented to create a heterotetramer displaying V
Development of 3D Printed Biodegradable, Entirely X‐ray Visible Stents for Rabbit Carotid Artery Implantation
Authors: Yihong Shen, Chaojie Tang, Binbin Sun, Yufan Wu, Xiao Yu, Jie Cui, Mianmian Zhang, Mohamed EL‐Newehy, Hany EL‐Hamshary, Peter Barlis, Wu Wang, Xiumei Mo
Journal: Advanced Healthcare Materials (2024)

Abstract Biodegradable stents are considered a promising strategy for the endovascular treatment of cerebrovascular diseases. The visualization of biodegradable stents is of significance during the implantation and long‐term follow‐up. Endowing biodegradable stents with X‐ray radiopacity can overcome the weakness of intrinsic radioparency of polymers. Hence, this work focuses on the development of an entirely X‐ray visible biodegradable stent (PCL‐KIO 3 ) composed of polycaprolactone (PCL) and potassium iodate via physical blending and 3D printing. The in vitro results show that the introduction of potassium iodate makes the 3D‐printed PCL stents visualizable under X‐ray. So far, there is inadequate study about polymeric stent visualization in vivo. Therefore, PCL‐KIO 3 stents are implanted into the rabbit carotid artery to evaluate the biosafety and visibility performance. During stent deployment, the visualization of the PCL‐KIO 3 stent effectively helps to understand the position and dilation status of stents. At 6‐month follow‐up, the PCL‐KIO 3 stent could still be observed under X‐ray and maintains excellent vessel patency. To sum up, this study demonstrates that PCL‐KIO 3 stent may provide a robust strategy for biodegradable stent visualization.
An AIE Controlled “Off‐On” Cu<sup>2+</sup>‐Sensitive Probe for Early Detection of Renal Fibrosis
Authors: Jie Zhou, Fusui Luo, Xiaomeng Dong, Huili Ma, Min Guan, Jin Zhang, Yiwen Sun, Junfen Feng
Journal: Advanced Healthcare Materials (2024)

Abstract Early detection of renal fibrosis (RF) is very important given that it is irreversible when it progresses to the terminal stage. A key marker of RF pathogenesis is activation of myomyofibroblasts, and its targeted imaging may be a promising approach for early detection of RF, but no study has directly imaged activation of renal myomyofibroblasts. Cu 2+ plays a major role in the fibrotic activity of myofibroblasts. Herein, inspired by that Cu 2+ can complex with bovine serum albumin (BSA), BSA‐Ag 2 S quantum dots (QDs) with aggregation‐induced emission (AIE) property are synthesized. Then BSA‐Ag 2 S QDs are modified by chitosan (CS) with renal targeting and hyaluronic acid (HA) with myofibroblast targeting to obtain the AIE assay system (QDs@CS@HA). The system is simple to synthesize, and produces a rapid NIR fluorescence signal turn‐on response and a low detection limit of 75 × 10 −9 m to Cu 2+ . In addition, cellular and animal experiments have shown that QDs@CS@HA has good biosafety and cell‐targeted imaging capability for RF. Based on the successful application of QDs@CS@HA and the mechanism of RF progression in early RF detection, it is expected that QDs@CS@HA may detect RF before the appearance of clinical symptoms.
The unique risk factor profile of triple-negative breast cancer: a comprehensive meta-analysis
Authors: Nitya Kumar, Sarah Ehsan, Shahana Banerjee, Claudia Fernandez Perez, Isabelle Lhuilier, Jillian Neuner, Tara Friebel-Klingner, Oluwadamilola M Fayanju, Bindhu Nair, Sara Anjum Niinuma, Shivangi Nampoothiri, Anne Marie McCarthy
Journal: JNCI Journal of the National Cancer Institute (2024)

Triple-negative breast cancer (TNBC) has a poor prognosis compared with other breast cancer subtypes. This systematic review and meta-analysis examines whether known risk factors for breast cancer are also associated with TNBC in adult women.
Virtual Reality and Transcranial Direct Current Stimulation for Posttraumatic Stress Disorder
Authors: Mascha van ’t Wout-Frank, Amanda R. Arulpragasam, Christiana Faucher, Emily Aiken, M. Tracie Shea, Richard N. Jones, Benjamin D. Greenberg, Noah S. Philip
Journal: JAMA Psychiatry (2024)

Importance Posttraumatic stress disorder (PTSD) is a common psychiatric disorder that is particularly difficult to treat in military veterans. Noninvasive brain stimulation has significant potential as a novel treatment to reduce PTSD symptoms. Objective To test whether active transcranial direct current stimulation (tDCS) plus virtual reality (VR) is superior to sham tDCS plus VR for warzone-related PTSD. Design, Setting, and Participants This double-blind randomized clinical trial was conducted among US military veterans enrolled from April 2018 to May 2023 at a secondary care Department of Veterans Affairs hospital and included 1- and 3-month follow-up visits. Participants included US military veterans with chronic PTSD and warzone-related exposure, recruited via referral and advertisement. Patients in psychiatric treatment had to be on a stable regimen for at least 6 weeks to be eligible for enrollment. Data were analyzed from May to September 2023. Intervention Participants were randomly assigned to receive 2-mA anodal tDCS or sham tDCS targeted to the ventromedial prefrontal cortex, during six 25-minute sessions of standardized warzone VR exposure, delivered over 2 to 3 weeks. Main Outcomes and Measures The co–primary outcomes were self-reported PTSD symptoms, measured via the PTSD checklist for DSM-5 (PCL-5), alongside quality of life. Other outcomes included psychophysiological arousal, clinician-assessed PTSD, depression, and social/occupational function. Results A total of 54 participants (mean [SD] age, 45.7 [10.5] years; 51 [94%] males) were assessed, including 26 in the active tDCS group and 28 in the sham tDCS group. Participants in the active tDCS group reported a superior reduction in self-reported PTSD symptom severity at 1 month ( t = −2.27, P = .02; Cohen d = −0.82). There were no significant differences in quality of life between active and sham tDCS groups. Active tDCS significantly accelerated psychophysiological habituation to VR events between sessions compared with sham tDCS ( F 5,7689.8 = 4.65; P &amp;amp;lt; .001). Adverse effects were consistent with the known safety profile of the corresponding interventions. Conclusions and Relevance These findings suggest that combined tDCS plus VR may be a promising strategy for PTSD reduction and underscore the innovative potential of these combined technologies. Trial Registration ClinicalTrials.gov Identifier: NCT03372460
Correction: GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review
Authors: Paula Rodriguez-Otero, Niels W. C. J. van de Donk, Kodandaram Pillarisetti, Ingrid Cornax, Deeksha Vishwamitra, Kathleen Gray, Brandi Hilder, Jaszianne Tolbert, Thomas Renaud, Tara Masterson, Christoph Heuck, Colleen Kane, Raluca Verona, Philippe Moreau, Nizar Bahlis, Ajai Chari
Journal: Blood Cancer Journal (2024)
A commentary on ‘Risk factors for postoperative delirium: An umbrella review of systematic reviews’
Authors: Li Guo, Qingxia Yu, Na Liu
Journal: International Journal of Surgery (2024)

Department of Anesthesiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University Li Guo and Qingxia Yu equally contributed to the study Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: shanxi cancer hospital, CHINA. E-mail address: [email protected] (Na Liu). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Assessing the application of barbed sutures in comparison to conventional sutures for surgical applications: a global systematic review and meta-analysis of preclinical animal studies
Authors: Nanyan Xiang, Yifei Lin, Xiaoyi Su, Zifan Hu, Jinyu Zhou, Yi Wu, Liang Du, Jin Huang
Journal: International Journal of Surgery (2024)

Background: Following an initiative published by Lancet in 2002 and an IDEAL-D framework, the value of preclinical animal studies has garnered increasing attention in recent research. Numerous preclinical animal experiments tried to generate evidence to guide the development of barbed sutures. However, discernible drawbacks and incongruities in outcomes have emerged between clinical and preclinical animal studies. Therefore, this meta-analysis aimed to review the preclinical animal experiments comparing barbed sutures with conventional sutures. We hope to facilitate clinical translation of barbed sutures by evaluating effectiveness, safety, and physical properties/reliability. Materials and Methods: A systematic search of PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov was conducted to identify controlled preclinical animal experiments comparing barbed sutures with conventional sutures. The risk of bias was assessed using SYRCLE. GRADE approach was used to evaluate evidence quality. Revman was applied to analyze all the data. Subgroup, sensitivity, and meta-regression analyses were also performed. Results: A total of 55 articles were eligible with low to moderate quality, including 1937 samples from 10 different animal species across 25 surgical procedures. Barbed suture exhibited a significant reduction in suture time, limited change in Cross-Sectional Area (CSA), and decreased instances of tissue disruption (all P ＜0.05). Subgroup analyses, considering both clinical and research significance, indicated that barbed sutures might cause more specific adverse events and demonstrate suboptimal performance of physical properties/reliability. Meta-regression suggested that heterogeneity resulted from variations in studies and animal models. Conclusion: Although barbed suture demonstrated superiority in numerous surgeries for time efficiency, its safety and physical properties/reliability might be influenced by diverse preclinical models, sutures’ brand, surgeries, and anatomical sites. Further evaluation, based on standardized and well-designed animal experiments, is essential for medical device development and applications in human beings.
A commentary on ‘Impact of sarcopenia on outcomes in surgical patients: a systematic review and meta-analysis’
Authors: Lin-chuan Liang, Zhi-yu Peng, Jian-dong Mei
Journal: International Journal of Surgery (2024)

aDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China bWestern China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu, China Assistance with the study: none. Letter to the editor. Lin-chuan Liang and Zhi-yu Peng: These authors contributed equally to this work and joint first authors. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. *Corresponding author. Address: No. 37, Guoxue Alley, Chengdu 610041, China. E-mail address: [email protected] (J. D. Mei). Supplemental Digital Content is available for this article. Direct URL citations are provided in the HTML and PDF versions of this article on the journal's website, www.lww.com/international-journal-of-surgery. Published online ■ ■ This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Results of a phase I trial with Haploidentical <scp>mbIL</scp>‐21 ex vivo expanded <scp>NK</scp> cells for patients with multiply relapsed and refractory <scp>AML</scp>
Authors: Stefan O. Ciurea, Piyanuch Kongtim, Samer Srour, Julianne Chen, Doris Soebbing, Elizabeth Shpall, Katayoun Rezvani, Robin Nakkula, Aarohi Thakkar, Ella C. Troy, Alex A. Cash, Gregory Behbehani, Kai Cao, Jolie Schafer, Richard E. Champlin, Dean A. Lee
Journal: American Journal of Hematology (2024)

Abstract Natural killer (NK)‐cells have potent anti‐tumor effects, yet it remains unclear if they are effective for patients with relapsed acute myeloid leukemia (AML). In a phase I clinical trial, we treated 12 patients (median age 60 years) with refractory AML (median 5 lines of prior therapy, median bone marrow blast count of 47%) with fludarabine/cytarabine followed by 6 infusions of NK‐cells expanded from haploidentical donors using K562 feeder cells expressing membrane‐bound IL21 and 4‐1BBL. Patients received 10 6 –10 7 /kg/dose. No toxicity or graft‐versus‐host disease (GVHD) was observed and MTD was not reached. Seven patients (58.3%) responded and achieved a complete remission (CR) with/without count recovery. Median time to best response was 48 days. Five responding patients proceeded to a haploidentical transplant from the same donor. After a median follow‐up of 52 months, 1‐year overall survival (OS) for the entire group was 41.7%, better for patients who responded with CR/CRi (57.14%), and for patients who responded and underwent transplantation (60%). Persistence and expansion of donor‐derived NK‐cells were identified in patients' blood, and serum IFNγ levels rose concurrently with NK cell infusions. A higher count‐functional inhibitory KIR was associated with higher likelihood of achieving CR/CRi. In conclusion, we observed a significant response to ex vivo expanded NK‐cell administration in refractory AML patients without adverse effects.
C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis
Authors: Baokui Ye, Binfeng Chen, Chaohuan Guo, Ningjing Xiong, Yuefang Huang, Mengyuan Li, Yimei Lai, Jin Li, Mianjing Zhou, Shuang Wang, Shuyi Wang, Niansheng Yang, Hui Zhang
Journal: Molecular Therapy (2024)
A commentary on ‘The efficacy and safety of hydrotherapy in patients with knee osteoarthritis: a meta-analysis of randomized controlled trials’
Authors: Chuanpeng Liu, Ning Jia, Yuanyuan Zhang, Jiaen Yang
Journal: International Journal of Surgery (2024)

aDepartment of rehabilitation, Renmin Hospital, Hubei University of Medicine, Shiyan City, China, 442000 bDepartment of TCM Rehabilitation, The People's Hospital of Gaoming District of Foshan, Guangdong, China, 528500 cDepartment of radiology, Renmin Hospital, Hubei University of Medicine, Shiyan City, China, 442000 Chuanpeng Liu, Ning Jia Both authors contributed equally to this article. This article does not refer to any raw data. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: E-mail address: [email protected] (J. Yang) This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Modulation of chronic obstructive pulmonary disease progression by antioxidant metabolites from <i>Pediococcus pentosaceus</i> : enhancing gut probiotics abundance and the tryptophan-melatonin pathway
Authors: Yiting Liu, Longjie Li, Jing Feng, Bing Wan, Qiang Tu, Wei Cai, Fa Jin, Guiying Tang, Lígia R. Rodrigues, Xiuwei Zhang, Jia Yin, Yunlei Zhang
Journal: Gut Microbes (2024)

Chronic obstructive pulmonary disease (COPD), a condition primarily linked to oxidative stress, poses significant health burdens worldwide. Recent evidence has shed light on the association between the dysbiosis of gut microbiota and COPD, and their metabolites have emerged as potential modulators of disease progression through the intricate gut-lung axis. Here, we demonstrate the efficacy of oral administration of the probiotic Pediococcus pentosaceus SMM914 (SMM914) in delaying the progression of COPD by attenuating pulmonary oxidative stress. Specially, SMM914 induces a notable shift in the gut microbiota toward a community structure characterized by an augmented abundance of probiotics producing short-chain fatty acids and antioxidant metabolisms. Concurrently, SMM914 synthesizes L-tryptophanamide, 5-hydroxy-L-tryptophan, and 3-sulfino-L-alanine, thereby enhancing the tryptophan-melatonin pathway and elevating 6-hydroxymelatonin and hypotaurine in the lung environment. This modulation amplifies the secretion of endogenous anti-inflammatory factors, diminishes macrophage polarization toward the M1 phenotype, and ultimately mitigates the oxidative stress in mice with COPD. The demonstrated efficacy of the probiotic intervention, specifically with SMM914, not only highlights the modulation of intestine microbiota but also emphasizes the consequential impact on the intricate interplay between the gastrointestinal system and respiratory health.
A commentary on “The effect of biofeedback pelvic floor training with ACTICORE1 on fecal incontinence A prospective multicentric cohort pilot study”
Authors: Yanxia Hu, Huaxiang Deng, Guizhen Li, Jianxia Zhang, Mengying Zhang
Journal: International Journal of Surgery (2024)

Hu, Yanxia; Deng, Huaxiang; Li, Guizhen; Zhang, Jianxia; Zhang, Mengying Author Information
Generation of a virus‐like particles based vaccine against <scp>IgE</scp>
Authors: Zahra Gharailoo, Kevin Plattner, Gilles Augusto, Paul Engeroff, Monique Vogel, Martin F. Bachmann
Journal: Allergy (2024)

Anti-IgE immunotherapy with monoclonal antibodies represents a breakthrough in treatment of severe allergic diseases. However, drawbacks such as short half-life and high price are not negligible. Our objective is to develop an anti-IgE vaccine based on virus-like particles (VLPs) which can induce long-lasting neutralizing IgG anti-IgE antibodies reducing allergic responses without causing intrinsic mast cell activation due to IgE cross-linking.