tbuckley/cabot-search huggingface dataset:
Abstract 871: Mechanisms Of Vascular T Cell Infiltration In Angiotensin II Dependent Hypertension. Potential Role Of Ccr5-RANTES.
Authors: Tomasz J Guzik, Nyssa Hoch, Louise McCann, Heinrich Lobb, Kathryn A Brown, Ayaz Rahman, Jorg Goronzy, Cornelia Weyand, David G Harrison
Journal: Circulation (2007)

We recently found that the increase in blood pressure, vascular superoxide and aortic hypertrophy caused by chronic low-dose angiotensin II (Ang II) is markedly blunted in RAG-1−/ − mice, which lac...
P0746 : Low viraemia in HCV-infected haemodialysed patients depends on IL28B genotype
Authors: S. Frankova, M. Jirsa, R. Senkerikova, M. Neroldova, M. Volfova, V. Hejda, D. Merta, O. Viklicky, J. Spicak, J. Sperl
Journal: Journal of Hepatology (2015)
Measuring quality of life: Who should measure quality of life?
Authors: J. Addington-Hall
Journal: BMJ (2001)

This is the fourth in a series of five articles 

One of the reasons behind the rapid development of quality of life measures in health care has been the growing recognition of the importance of understanding the impact of healthcare interventions on patients' lives rather than just on their bodies. This is particularly important for patients with chronic, disabling, or life threatening diseases who live without the expectation of cure and have conditions that are likely to have an impact on their physical, psychological, and social wellbeing.

Health professionals frequently make quality of life judgments when making decisions about the care of disabled patients,1 and the professional's view on expected quality of life is often the key factor in determining whether effective treatment for a life threatening condition will be given or withdrawn.2 Professionals' perceptions may, however, be at odds with those held by their patients.3 It is therefore important to ask patients to assess their own quality of life using one of a growing number of reliable and valid measures.

Choosing an appropriate measure and using it in clinical practice can be problematic.4 Deciding to use a measure, however, presupposes that patients are able to assess their own quality of life and complete a quality of life measure. Some patients—and in some conditions many patients—are unable to do this because of cognitive impairments, communication deficits, severe distress caused by their symptoms, or because the quality of life measure is too burdensome physically or emotionally.5 These may be precisely the patients for whom information on quality of life is most needed to inform clinical decision making. Rather than lose all information on that patient, someone else (a family member or health professional) may be asked to act as a proxy or surrogate.

In this paper …
Clinical Outcomes With Bioabsorbable Polymer- Versus Durable Polymer-Based Drug-Eluting and Bare-Metal Stents
Authors: Tullio Palmerini, Giuseppe Biondi-Zoccai, Diego Della Riva, Andrea Mariani, Manel Sabaté, Pieter C. Smits, Christoph Kaiser, Fabrizio D'Ascenzo, Giacomo Frati, Massimo Mancone, Philippe Genereux, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2013)
Abstract 11793: Secretoneurin, a Peptide Associated with Mortality in Heart Failure, Modulates Cardiomyocyte Calcium Homeostasis
Authors: Anett H. Ottesen, William E. Louch, Cathrine Carlson, Ole J. B. Landsverk, Arne D. Hoiseth, Mats Stridsberg, Erik Oie, Torbjorn Omland, Geir Christensen, Helge Rosjo
Journal: Circulation (2011)

Background: In patients hospitalized with acute heart failure (HF), we have found a close association between plasma secretoneurin (SN) levels and the severity of HF, including a graded increase in...
Abstract 3263: Enhanced Cardiac Inflammation and Myocardial Fibrosis in Ovariectomized, Pressure-overloaded Rats: A Possible Mechanism of Aggravation of Diastolic Dysfunction in the Post-menopause
Authors: Takahiro Mori, Hisashi Kai, Hidemi Kajimoto, Hiroshi Kudo, Narimasa Takayama, Ayami Ikeda, Suguru Yasuoka, Takahiro Anegawa, Tsutomu Imaizumi
Journal: Circulation (2009)

Background: The prevalence of diastolic dysfunction is high in hypertensives, particularly in postmenopausal women. However, the pathogenesis remains unknown. We have shown that pressure overload (...
Abstract 11730: A New Index to Characterize Asymptomatic Patients with Essential Hypertension, a Wave to Mitral Flow Propagation Velocity Ratio
Authors: Miguel Rivera, Esther Rosello, Luis Martinez-Dolz, Jose R Calabuig, Lilian Grigorian, Fernando Garcia de Burgos, Pedro Morillas, Raquel Cortes, Luis Almenar, Jose Ramon Gonzalez-Juanatey, Ignacio Sanchez-Lazaro, Antonio Salvador, Teresa Lozano, Catheline Lauwers, Placido Orosa, Vicente Miro, Anastasio Montero, Federico Soria, Alejandro Jordan, Vicente Climent, Luis Mainar, Isabel Antorrena, Jose-Leandro Perez-Bosca, Maria-Jose Sancho-Tello, Rafael Paya, Manuel Portoles, Vicente Bertomeu
Journal: Circulation (2011)

Introduction: Changes of peak flow velocity during atrial contraction (A wave) are known to be related with diastolic abnormalities in left ventricular hypertrophy (LVH). Mitral flow propagation velocity (Vp) represents a non-invasive index for assessing LV relaxation. Whether the A/Vp ratio could be useful to characterize asymptomatic patients with essential hypertension (HT) remains unknown. Methods: We have studied 270 patients without arrhythmia or heart failure, age 60±13, diagnosed with HT. NT-proBNP (pg/ml) was determined. Vp (cm/s) and A wave (cm/s) were calculated. We also measured systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), E/A, left atrial size (LAS, mm), deceleration time (DT, ms), IVRT (ms), ejection fraction (EF), body mass index (BMI) and left ventricular mass index (LVMI). Results: For the whole population NT-proBNP levels were 147±266, A/Vp 1.8±0.85, SBP 148±20, DBP 87±11, PP 61±18, A wave 78±21, E/A 0.9±0.25, Vp 48±11, LAS 33.7±0.42, DT 200±38, IVR...
Global atmospheric change and human health.
Authors: W.T. Piver
Journal: Environmental Health Perspectives (1991)

On November 6-7, 1989, the National Institute of Environmental Health Sciences (NIEHS) held a Conference on Global Atmospheric Change and Human Health. Since this conference, presented papers have been transformed and revised as articles that address several potential impacts on human health of global warming. Coming when it did, this was a very important conference. At the present time, there is still much uncertainty about whether or not global warming is occurring and, if it is, what effect it will have no human health. All the participants in this conference recognized this uncertainty and addressed potential impacts on human health if surface temperatures continue to rise and greater amounts of shorter wavelength ultraviolet (UV) radiation continue to reach the earth's surface as a result of depletion of the ozone layer. Because global warming and ozone depletion will occur over many decades, adverse impacts on human health and the environment may not be reversible. In short, we are in the midst of a huge geophysical experiment with global climate, and we will not know what the outcome will be for many years.
The importance of dementia support groups
Authors: Jill Walton, Natalie Ryan, Sebastian Crutch, Jonathan D Rohrer, Nick Fox
Journal: BMJ (2015)

Robinson and colleagues refer to non-Alzheimer diagnoses of dementia.1 These less typical diagnoses pose complex problems for those with the disease and for their families, friends, and carers. When these forms of dementia affect younger people the problems can be even more challenging.

When asking the question: “What constitutes best practice in early intervention?” we must acknowledge that people …
Early prediction of anti-epidermal growth factor receptor (EGFR) therapy with 18[F]FDG-PET: A preclinical and clinical correlation
Authors: W. Ma, A. Jimeno, P. Kulesza, A. Chan, X. Zhang, W. A. Messersmith, M. L. Gillison, M. G. Pomper, A. A. Forastiere, M. Hidalgo
Journal: Journal of Clinical Oncology (2007)

14064 Background: Predictive biomarkers for response to anti-EGFR therapy are of significant clinical importance. We hypothesized that early changes in 18[F]FDG tumor uptake predict response to anti-EGFR therapy. We investigated this in a mice model and correlated these findings with human patients undergoing anti-EGFR therapy. Methods: Mice bearing two head and neck squamous cell cancer (HnNSCC) xenografts (Hep2, Cal27) received vehicle or erlotinib for 3 weeks. 18[F]FDG uptake were imaged with small animal micro- PET at baseline and after 1 week of therapy, and reported in SUVmax. For clinical correlation, human patients with HnNSCC receiving erlotinib were identified from an ongoing clinical trial. 18[F]FDG-PET images were obtained at baseline and after 2 weeks of erlotinib monotherapy. Tumor specimens were obtained by fine-needle aspiration biopsy at the same time as PET. A panel of pharmacodynamic markers (including Ki-67 and pMAPK) were assessed . Results: Hep2 was resistant to erlotinib therapy (Tumor/Control [T/C]: 0.8) while Cal27 was sensitive (T/C: 0.2). SUVmax in the resistant Hep2 xenografts was not significantly different from the control (86% ± 70% of control) while SUVmax in the treated sensitive Cal27 xenografts showed a significant decrease than control (-2% ± 7%). Ki-67 in the treated Hep2 was not significantly different from control while that in Cal27 was &lt;50% of control. For clinical correlation, ki-67 score was higher after 2 weeks in the patient resistant to erlotinib monotherapy by 18[F]FDG-PET (SUVmax increased by 14%, ± 11%) and was lower in the patient who was 18[F]FDG-PET sensitive (SUVmax decreased by 56%, ± 13%). pMAPK decreased in all cases and had a poor correlation with efficacy. Conclusions: Early dynamic changes in 18[F]FDG tumor uptake is predictive of response to anti-EGFR therapy and correlates with changes in ki-67 expression, both in a preclinical and a clinical scenario. No significant financial relationships to disclose.
Characterization of depression in war-related posttraumatic stress disorder
Authors: S M Southwick, R Yehuda, E L Giller
Journal: American Journal of Psychiatry (1991)

Many patients with posttraumatic stress disorder (PTSD) have symptoms of depression, but operationalized psychological constructs related to depression have not been used extensively in characterizing affective symptoms of PTSD. The authors' objective is to better characterize the affective component of PTSD.The subjects were 45 male psychiatric inpatients at a Veterans Administration medical center; 28 met DSM-III-R criteria for PTSD and 17 met Research Diagnostic Criteria (RDC) for major depressive disorder. All of the subjects with PTSD were Vietnam veterans. The 21-item Hamilton Rating Scale for Depression was used to assess state measures of symptom severity, and the Depressive Experiences Questionnaire was used to measure dimensions of dependency, self-criticism, and self-efficacy.The mean total Hamilton scale score of the patients with PTSD was nonsignificantly higher than that of the patients with major depressive disorder; patients with PTSD had higher scores on almost all individual Hamilton symptoms, particularly insomnia, somatic anxiety, and diurnal variation. Patients with PTSD had significantly higher scores on the self-criticism scale but not on the dependency and self-efficacy scales of the Depressive Experiences Questionnaire. The scores of patients with PTSD on the dependency and self-criticism scales were negatively correlated. No significant differences between patients with PTSD with and without concurrent major depressive disorder were observed.Characterization of such depressive dimensions of PTSD as dependency and self-criticism may have important clinical implications.
Abstract 16162: Impact of CT-Based Attenuation Correction Imaging With a High Speed Cadmium-Zinc-Telluride SPECT Myocardial Perfusion Image to Resolve Inferior Wall Attenuation
Authors: Shimpei Ito, Akihiro Endo, Takashi Sugamori, Nobuyuki Takahashi, Kazuaki Tanabe
Journal: Circulation (2014)

Background: Cadmium-zinc-telluride (CZT) detectors are faster and produce higher quality images as compared to conventional SPECT cameras. However, CZT camera images still have not overcome the attenuation of inferior wall as standard camera. Adding prone and CT attenuation correction (CTAC) images have been shown to improve diagnostic performance to detect ischemia of inferior wall. Utility of CT attenuation corrected myocardial perfusion image (MPI) with NM 530c is uncertain.

Methods: The study population included 83 patients (77% men; mean age 71±9 years) who underwent 1-day 99mTc-tetrofosmin pharmacologic rest/stress examination using CZT camera (GE Discovery NM 530c) a day before CAG. We diagnosed reversible perfusion defects visually on MPI (supine, prone and CTAC) as ischemia until CAG. CTAC images reconstructed using CT-based transmission data with the16-slice CT (GE Discovery NM/CT 670). Cardiac ischemia was defined as a luminal narrowing of ≧90% stenosis by CAG. In the cases of intermediate stenosis (75% stenosis), fractional flow reserve (FFR) was calculated. Per-patient sensitivity, specificity and accuracy of supine, prone and CTAC to detect inferior to lateral wall ischemia were calculated.

Results: Per-patient sensitivity, specificity, and accuracy of supine, prone and CTAC images to predict CAD in CAG were 42%, 88%, 77%, 67%, 81%, 78%, 61%, 93% and 85%, respectively (Figure).

Conclusions: Myocardial perfusion imaging with CZT device improves diagnostic performance of inferior to lateral wall ischemia adding to CTAC image.

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Abstract 16221: Scribble-Mediated Polarity of Endothelial Cells is Required for Angiogenesis
Authors: U. Ruth Michaelis, Benno Jungblut, Michael Potente, Marc Tjwa, David Kaluza, Carmen Urbich, Katalin Wandzioch, Christoph Kruse, Jean-Paul Borg, Ralf P Brandes
Journal: Circulation (2010)
Abstract 2668: Critical Role of Granzyme B in Left Ventricular Remodeling after Acute Myocardial Infarction
Authors: Hideyuki Kondo, Yukihiro Hojo, Yoshioki Nishimura, Nozomu Takahashi, Tomokazu Ikemoto, Takaaki Katsuki, Kazuyuki Shimada
Journal: Circulation (2008)

Background: Granzyme B is a member of the serine esterase family produced by cytotoxic T lymphocytes (CTLs), and has an important role in cellular apoptosis and extracellular matrix degradation. We hypothesized that granzyme B is involved in left ventricular (LV) remodeling after acute myocardial infarction (AMI). Objectives: To elucidate the role of granzyme B in LV remodeling after AMI. Subjects and methods: We employed 41 patients with the first AMI (mean age: 61.9±8.9 years old). We obtained peripheral blood on day 1, day 7 and day 14 after onset. Plasma levels of apoptosis-related molecules, including tumor necrosis factor α (TNFα), a soluble form of the Fas ligand (sFasL) and granzyme B were measured. We checked the activation of CTLs by flow cytometry. Patients were treated by percutaneous coronary intervention within 12 hours after onset. Successful myocardial reperfusion (TIMI flow grade 2 or 3) was accomplished in all patients. LV end-diastolic volume index (LVEDVI) was calculated on day 1 and 6 months after onset. Results: Plasma levels of TNFα, sFasL and granzyme B increased significantly after the onset of AMI (TNFα; day 1: 1.6±0.47, day 7: 3.3±0.65, day14: 4.0±1.2 pg/ml, p&lt;0.05, sFasL; day 1: 72±5.2, day 7: 86±6.7, day14: 95±7.3 pg/ml, p&lt;0.05, granzyme B; day 1: 63±18.4, day 7: 283±57.8, day14: 210.9±46.3 pg/ml, p&lt;0.001). The percentage of CD69± to CD3+ CD8+ lymphocytes was significantly increased (CD69+/CD3+ CD8+; day 1: 14.5±1.7, day 7: 15.8±1.2, day 14: 19.1±1.4%, p&lt;0.05), suggesting that CTLs were activated after onset. Univariate regression analysis showed a significant positive correlation between plasma granzyme B level on day 14 and fold-increase in LVEDVI (r=+0.45, p&lt;0.01). No significant correlation was observed between TNFα and changes in LVEDVI, or sFasL and changes in LVEDVI. Stepwise multivariate regression analysis showed that the plasma granzyme B level on day 14 is a significant explanatory variable for changes in LVEDVI (β = +0.53, p&lt;0.001). Conclusions: These results first indicate that among proapoptic molecules, granzyme B has a critical role in the progression of LV remodeling after AMI.
Abstract 2316: Ranolazine, a Late Sodium Current Inhibitor, as an Adjunct to Cardioplegia Further Reduces Contracture during Ischemia and Reperfusion
Authors: Hyosook Hwang, Joseph M Arcidi, Sharon L Hale, Boris Z Simkhovich, Luiz Belardinelli, Arvinder Dhalla, John C Shryock, Robert A Kloner
Journal: Circulation (2008)

Although cardioplegia (CP) protects myocardium during ischemic cardiac arrest, cardioplegic preservation can be suboptimal for increasingly complex cardiac surgical patients. Ranolazine (Ran), a novel antianginal agent, was recently shown to mitigate ischemia-induced Ca 2+ overload via its inhibitory effects on the late Na + current, but the benefit of Ran during cardioplegic arrest is not known. The purpose of the study was to investigate the therapeutic potential of Ran as an adjunct to CP. Hearts isolated from female Sprague-Dawley rats were Langendorff-perfused and exposed to normothermic global ischemia for 40 min followed by 30-min reperfusion (I/R). Three groups were studied: control buffer (n = 10); crystalloid CP (Fremes, n = 12); CP supplemented with Ran (n = 12). CP was bolus-injected with or without Ran at the time of ischemia. End-diastolic pressure (EDP), developed pressure, dP/dt min , and dP/dt max were measured throughout the study. CP significantly delayed onset of ischemic contracture (defined as a time to 20 mmHg of EDP), compared to control (25 ± 2 min in CP alone vs. 12 ± 1 min in control, p &lt; 0.05). Ran added to CP further delayed the time to contracture (34 ± 2 min in Ran, p &lt; 0.05 compared to CP alone). Consistent with these findings, the area under the diastolic pressure curve during the entire period of ischemia was significantly smaller in CP + Ran versus CP alone (p &lt; 0.05). I/R caused dramatic elevations in EDP during reperfusion. CP lessened the extent of the reperfusion contracture (32 ± 3 mmHg in CP alone vs. 76 ± 3 mmHg in control, p &lt; 0.05). Addition of Ran to CP further lessened the contracture (17 ± 2 mmHg in Ran, p &lt; 0.05 compared to CP alone). I/R severely depressed systolic cardiac contractile function. The impairment in contractile function was significantly reduced by CP, as well as CP + Ran, but there was no statistical difference between the two groups. While CP alone reduced the onset of cardiac contracture in this model of I/R, addition of Ran to CP further enhanced the cardioprotection. These results suggest the potential therapeutic efficacy of Ran as an adjunct to CP and further support the protective role of late Na + current inhibition.
Metabolic Studies on Patients with Resistant Heart Failure Treated by Spironolactone
Authors: T A BAYLEY, P G FORBATH, J K WILSON, H P HIGGINS
Journal: JAMA (1963)

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Abstract 4193: Prevalence, Pattern and Prognostic Relevance of Myocardial Late Gadolinium Enhancement in Marathon Runners
Authors: Stefan Mohlenkamp, Frank Breuckmann, Kai Nassenstein, Nils Lehmann, Axel Schmermund, Susanne Ladd, Thomas Schlosser, Burkhard Sievers, Karl-Heinz Jockel, Gerd Heusch, Jorg Barkhausen, Raimund Erbel
Journal: Circulation (2008)
Abstract 13390: Long-Term Adherence to the Mediterranean Diet Has Beneficial Effect on Biventricular Systolic and Diastolic Function in Chronic Heart Failure Patients
Authors: Christina Chrysohoou, Demosthenes Panagiotakos, Christos Antoniou, George Metallinos, Christos Pitsavos, Evaggelos Economou, Stella Brili, Christina M Kastorini, Apostolis Tsantilas, George Tsitsinakis, Dimitris Tousoulis, Christodoulos Stefanadis
Journal: Circulation (2011)
Abstract 14918: Blood Product Transfusion and Postoperative Bleeding Can Be Predicted by Platelet Function Analysis PFA-100® in Children Undergoing Cardiac Surgery
Authors: Muhammad M Zubair, David K Bailly, Alan R Hohimer, Sunil Saharan, Gurion Lantz, Rachel E Sunstrom, Lynn K Boshkov, Paul Sochacki, Stephen M Langley
Journal: Circulation (2013)

Introduction: Excessive bleeding can be a problem during or after cardiac surgery. Cardiopulmonary bypass associated platelet dysfunction is an important determinant of coagulopathy. The PFA-100® t...
Abstract 2756: Prevention of Atrial Fibrillation Recurrence after Radiofrequency Catheter Procedure of Pulmonary Vein Isolation by Corticosteroids
Authors: Takashi Koyama, Yukio Sekiguchi, Hiroshi Tada, Takanori Arimoto, Hiro Yamasaki, Kenji Kuroki, Takeshi Machino, Kazuko Tajiri, Xu D Zhu, Miyako Kanemoto, Aiko Sugiyasu, Keisuke Kuga, Kazutaka Aonuma
Journal: Circulation (2008)

Background: Catheter based radiofrequency pulmonary vein isolation (PVI) has been shown to be an effective therapeutic option for controlling drug-refractory atrial fibrillation (AF); however, the recurrence of AF has become one of the major problems after procedure. Although the underlying mechanism of the AF recurrence is not well evaluated, previous reports indicated that inflammatory process could be associated with the onset of AF and the use of intravenous hydrocortisone reduced the incidence of AF after coronary artery bypass surgery. We therefore prospectively evaluated the efficacy of the hydrocortisone for the prevention of AF recurrence. Methods and Results: This study included consecutive 150 patients with drug-refractory paroxysmal AF. Patients were randomized to receive either hydrocortisone or matching placebos as follows: intravenous hydrocortisone (dose of 2mg/kg) was used in the day of operation, and oral hydrocortisone was administered (dose of 0.6mg/kg/day) for 3 days after PVI. Patients with non-PV-foci AF were excluded in this study (Control group; 4 patients, Hydrocortisone group; 6 patients). Various biophysical data were closely investigated between control group (n=71) and hydrocortisone group (n=69). Rate of total AF recurrence and immediate AF recurrence (recurrence of AF within 3 days after PVI) was significantly lower in hydrocortisone group than placebo group (total AF recurrence; 27.0% vs 46.1%, immediate AF recurrence; 6.7% vs 29.5%, p&lt;0.01). Number of patients who underwent second PVI (8.3% vs 23.1%, p&lt;0.01), rise of body temperature after the procedure (0.675°C vs 1.633°C, p=0.005), any sign of pericariditis (0% vs 6.4%, p&lt;0.01), high sensitive CRP level after the procedure (1.17mg/dl vs 2.09mg/dl, P=0.015) and the number of patients using antiarrhythmics (classIb, classIII) after the procedure (classIb; 0% vs 6.4%, classIII; 6.7% vs 26.9%, p&lt;0.01) were also significantly lower in hydrocortisone group than in placebo group. Conclusion: Transient use of hydrocortisone immediately after PVI can be one of the therapeutic options for the prevention of acute AF recurrence after PVI to avoid second procedure and/or the additional antiarrhythmic drug therapy.