Abstract 794: Comprehensive outcomes for after cancer health (COACH): Interim analysis of physical function data for individuals with diverse tumor types following primary cancer therapy
Authors: Marilyn Hammer, Robin Lally, Barbara Halpenny, Hajime Uno, Ijeoma Eche-Ugwu, Whitney Posada, Inga Van Wieren, Alexi Wright, Ayodeji Adeniji, Sarah Alzahid, Lauren A. Anderson, Betty Arceneaux, Jerry Armah, Elizabeth Arthur, Kristen Fessele, Laura Flora, Alyssa Garcia, Anneliese Gonzalez, Michael Harrison, Brian Hulbert, Mariah Jackson, Kaukab Jafry, Rebecca Johnson-Beller, Abbey Kaler, Ginny Kirklin, Jessica Krok-Schoen, Hilda H. Lewis, Jennifer Loftis, Debra Lyon, Kathrin Milbury, Ariana Mohan, Jasmine Moore, Estee Murray-Ross, Darcy Ponce, Leorey Saligan, Elham Samami, Rachael Schmidt, Grace Smith, Angela Starkweather, Maria Chang Swartz, Martha Thompson, Gisele Tlusty, Meagan Whisenant, Gloria Yang, Kelly J. Brassil
Journal: Cancer Research (2025)

Abstract Purpose: Wellness interventions are important for improving outcomes, including physical function (PF), in cancer survivors. The COACH study is a randomized, wait-list controlled trial assessing feasibility of a 6-month digital health coaching (DHC) program for individuals within one year of completing primary cancer therapy, and those with metastatic disease. Diverse patient-reported outcome (PRO), wearable, device, gut microbiome, and dietary data are collected up to once monthly from 675 individuals over 12 months. This interim analysis examined change in PF using the PROMIS Short Form v2.0-PF 10a. Methods: The analysis included a pooled sample of participants who completed baseline and 6-month assessments as of November 2024. Descriptive statistics evaluated trends in physical function by age, sex, enrollment site, metastatic disease, and tumor and primary treatment type. Summary Data: Among the 352 individuals enrolled across 7 study sites, 177 completed baseline and 6-month assessments to date. Mean age of participants was 59.7 (R 30-83, SD 11.8). Fourteen participants (8%) identified as Black or African American, 9 (5%) as Hispanic or Latino, 147 (83%) as non-Hispanic White, and 7 (4%) as other, including Asian, American Indian, or Alaskan Native. Mean PROMIS PF scores by analysis group are presented in Table 1. Conclusions: An interim analysis of PF data demonstrated trending improvements across all groups from baseline to 6 months, except at one site enrolling only individuals with metastatic breast cancer, for whom mean difference is lower than in those with non-metastatic disease. Minimally important differences in PROMIS PF for individuals with advanced cancer is 4-6 points. At study completion (July 2026), a full analysis will be conducted to explore differences in PF by various patient characteristics, and if and how DHC may impact these trends over time. Citation Format: Marilyn Hammer, Robin Lally, Barbara Halpenny, Hajime Uno, Ijeoma Eche-Ugwu, Whitney Posada, Inga Van Wieren, Alexi Wright, Ayodeji Adeniji, Sarah Alzahid, Lauren A. Anderson, Betty Arceneaux, Jerry Armah, Elizabeth Arthur, Kristen Fessele, Laura Flora, Alyssa Garcia, Anneliese Gonzalez, Michael Harrison, Brian Hulbert, Mariah Jackson, Kaukab Jafry, Rebecca Johnson-Beller, Abbey Kaler, Ginny Kirklin, Jessica Krok-Schoen, Hilda H. Lewis, Jennifer Loftis, Debra Lyon, Kathrin Milbury, Ariana Mohan, Jasmine Moore, Estee Murray-Ross, Darcy Ponce, Leorey Saligan, Elham Samami, Rachael Schmidt, Grace Smith, Angela Starkweather, Maria Chang Swartz, Martha Thompson, Gisele Tlusty, Meagan Whisenant, Gloria Yang, Kelly J. Brassil. Comprehensive outcomes for after cancer health (COACH): Interim analysis of physical function data for individuals with diverse tumor types following primary cancer therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 794.