tbuckley/cabot-search huggingface dataset:
Abstract 1660: Short-term Overexpression of CD36 in the Liver Augments Hepatic Lipid Storage and VLDL-triglyceride Secretion: Implications for Diet-Induced Obesity and Type 2 Diabetes
Authors: Debby P Koonen, Rene L Jacobs, Martin M Young, Dennis E Vance, Maria Febbraio, Jason R Dyck
Journal: Circulation (2006)
Use of magnetic resonance imaging and 31p-spectroscopy to explore muscle energetics in fibromyalgia patients
Authors: Didier Maquet, Marc Vanderthommen, Marie-Paule Lecart, Christophe Demoulin, A. Leroy-Willig, Jean-Louis Croisier, Jean-Michel Crielaard, P. Carlier
Journal: Annals of the Rheumatic Diseases (2007)
Burkitt’s lymphoma arising in the pancreas
Authors: A. V. Novoselac, R. J. Katz, D. S. Lessen, I. Yudelman
Journal: Journal of Clinical Oncology (2005)

6740 Background: While involvement of the pancreas by advanced non-Hodgkin’s lymphoma (NHL) is a recognized phenomenon, primary lymphomas arising from this site are comparatively rare. Methods: We report a case of an 84 year-old male with a primary Burkitt’s lymphoma of the pancreas. Results: The patient presented with abdominal pain and jaundice of a few days duration. Examination revealed a cachectic male with mucocutaneous and scleral icterus, abdominal tenderness without organomegaly and absence of adenopathy. Laboratory data: Hb 12.9 g/dl, WBC 11.1 x 109/L, Plt 240 x 109/L, AST 102 U/L, ALT 111 U/L, total bilirubin of 36.7 mg/dl and alkaline phosphatase 449 U/L. CT scan showed a 6.7 x 4.0 cm pancreatic head mass with dilatation of the biliary ducts and no evidence of thoracic, abdominal or retroperitoneal lymphadenopathy. The patient underwent biliary stent placement via ERCP. Brush biopsies were non-diagnostic. A CT guided needle biopsy of the lesion revealed atypical lymphocytes, with numerous mitoses and prominent “starry sky” pattern. Flow cytometry confirmed a population of monoclonal lambda restricted, CD10+, CD20+ and CD5- B-cells consistent with Burkitt’s lymphoma. The bone marrow was uninvolved. The patient denied HIV risk factors and declined testing. Primary pancreatic lymphomas represent less than 1% of all NHLs though nearly one third of NHL patients will develop pancreatic involvement at some point in their disease course. Though Burkitt’s lymphoma has been shown to frequently involve the pancreas in autopsy studies, its primary presentation arising in this location has not been reported in the English literature to our knowledge. Conclusions: Despite being one of the fastest growing malignancies in humans, Burkitt’s lymphoma can often be associated with good clinical outcomes. In contrast, adenocarcinoma of the pancreas, the most common primary malignancy of this organ, is frequently associated with a poor outcome. Though no information is available in the literature describing outcomes for patients with primary pancreatic Burkitt’s lymphoma, its potential for responsiveness to treatment may make this rare malignancy worthy of consideration in the differential diagnosis of a pancreatic mass. No significant financial relationships to disclose.
Lehrbuch der Enzyme: Chemie, physikalische Chemie und Biologie.
Authors: Carl Oppenheimer, Richard Kuhn
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 16936: The Glucagon-Like Peptide 1 Response to Oral Glucose Tolerance Testing is Associated with Coronary Artery Calcium in Type 2 Diabetes Mellitus
Authors: Claire K Mulvey, Ann M McNeill, Cynthia J Girman, Timothy W Churchill, Karen Terembula, Jane F Ferguson, Nehal N Mehta, Atif N Qasim, Michael R Rickels, Muredach P Reilly
Journal: Circulation (2012)

Introduction: Type 2 diabetes mellitus (T2DM) is characterized by decreased incretin effect and a blunted incretin response to meals. Whether the response of the incretin hormone glucagon-like pept...
Ongoing outbreak of West Nile virus infections in humans in Greece, July – August 2010
Authors: A Papa, K Danis, A Baka, A Bakas, G Dougas, T Lytras, G Theocharopoulos, D Chrysagis, E Vassiliadou, F Kamaria, A Liona, K Mellou, G Saroglou, T Panagiotopoulos
Journal: Eurosurveillance (2010)

Between early July and 22 August 2010, 81 cases of West Nile neuroinvasive disease were reported in the region of Central Macedonia, northern Greece. The median age of cases was 70 years. Encephalitis, meningoencephalitis or aseptic meningitis occurred mainly in patients aged 50 years or older. This is the first time that West Nile virus (WNV) infection has been documented in humans in Greece. Enhanced surveillance and mosquito control measures have been implemented.
Clinical Impact of Preoperative Sentinel Lymph Node Imaging With SPECT/CT in the Management of Interscapular Malignant Melanoma
Authors: Salih Ozguven, Serkan Gungor, Mustafa Aras, Bulent Sacak, Fuat Dede
Journal: Clinical Nuclear Medicine (2015)

A 31-year-old male patient with a biopsy-proven cutaneous malignant melanoma located in the interscapular area was referred to lymphoscintigraphy for preoperative sentinel lymph node mapping. Anterior and posterior planar images showed 3 hot spots suggesting left axillary sentinel nodes. Herein, we reported the contribution of preoperative SPECT/CT-guided sentinel lymph node excision on accurate staging, management, prognostic evaluation, and determination of the proper surgical positioning preoperatively.
Abstract 1425: VSOACs Play an Important Cardioprotective Role in Late Ischemic Preconditioning in Mouse Heart
Authors: Nathan D Bozeat, Laura Dwyer, Linda Ye, Tammy Y Yao, William J Hatton, Dayue Duan
Journal: Circulation (2006)

Background: Activation of volume-sensitive osmolyte and anion channels ( VSOACs ) has been shown to be involved in ischemic preconditioning (IPC) protection of isolated rabbit heart but the underlying molecular mechanisms remain unclear. Recent accumulative evidence strongly supports that ClC-3 may encode the  VSOACs  in the heart. Thus, ClC-3 knockout (KO) mice were used to directly test the hypothesis that activation of  VSOACs  may contribute to cardioprotection in both early and late IPC.  Methods: Multiple approaches including telemetry ECG and echocardiography were used to assess the cardiovascular phenotype under normal, stressed (treadmill or ischemia), and  in vivo  early and late IPC conditions in age matched ClC-3 wild type (WT), heterozygous (HT) and KO littermates.  Results:  Targeted disruption of ClC-3 gene caused a decrease in the body weight (21.2±1.3 vs WT 28.3±1.2 g, n=68, P  Early IPC significantly reduced infarct size caused by 30 min ischemia in all groups including ClC-3 KO mice (control 40.1±4.3% vs. IPC 22.7±3.7%, n=22, P  Late IPC significantly reduced infarction in WT (22.9 ± 3.2% vs control 45.7±5.4%, n=22, P  Conclusions: These results indicate that  VSOACs  may play an important cardioprotective role in the late IPC but not in the early IPC.
Handbook of Materia Medica for Trained Nurses, including the sections on Therapeutics and Toxicology and a Glossary of terms with dose and use of each drug.
Authors: John E. Groff
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Roentgen Anatomy: Roentgen anatomía
Authors: David Steel
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pneumolyse intrapleurale: L'opération de Jacobæus et la thoracocaustie d'après Maurer dans le pneumothorax artificiel.
Authors: Louis Sayé
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leukemic Polyradiculopathy Due to Blastic Plasmacytoid Dendritic Cell Neoplasm
Authors: William F. Qubty, Aref Al-Kali, Lyell K. Jones
Journal: JAMA Neurology (2015)

but, to our knowledge, there havebeen no reports of complications affecting more peripheralstructures.A76-year-oldmanwithaknownBPDCNpresentedwithsub-acute, progressive, symmetric lower extremity weakness and uri-nary retention. His examination demonstrated a severe flaccidquadriparesisandreducedmusclestretchreflexes,whichwereworseinthelowerlimbs,andleukemiacutis(Figure1).Healsohadmod-erateright-sidedptosisthathadbeenpresentforabout1month.Theptosis had been evaluated by use of contrast-enhanced magneticresonanceimagingofthebrainandorbits,whichdidnotrevealanabnormality, although multiple areas of cutaneous scalp demon-stratedrestrictionofdiffusionthatwasnotedtobeconsistentwithhismalignantneoplasm.Magneticresonanceimagingofhisentirespinerevealednodu-lar thickening and enhancement of the lumbosacral nerve roots(Figure 2). There was no abnormal signal or enhancement any-where in the spinal cord. Also noted were diffuse heterogeneousT1-andT2-weightedsignalabnormalitieswithinthebonemarrowsecondarytohisknownoncologicdisease.Analysisofcerebrospinalfluidsamplesobtainedfromthepa-tientrevealedthatthepatienthadawhitebloodcellcountof3397/μL(toconvertto×10
Abstract 14435: Changing Patterns Of Deaths Among Adult Survivors With Congenital Heart Disease: A 30-year Single Centre Experience
Authors: Matthias Greutmann, Daniel Tobler, Mehtap Greutmann-Yantiri, Erwin Oechslin, Larry Librach, Jack M Colman, Adrienne H Kovacs
Journal: Circulation (2010)

Introduction: Advances in heart surgery and cardiology care have dramatically improved survival for patients born with congenital heart disease (CHD) and almost all now survive to adulthood. Many o...
Protocols for Gynecologic and Obstetric Health Care
Authors: Mary Barger, Judith T. Fullerton, Vanda R. Lops, Mary Ann Rhode
Journal: Annals of Internal Medicine (1989)

A practical guide to women's healthcare that provides a concise outline of primary care gynecology and obstetrics. A superb quick reference, the text details patient management in areas of well-women gynecology, contraception, menopause, and antepartum, intrapartum, and postpartum care appropriate to a variety of birth settings. Each chapter addresses the purpose of the examination or encounter, essential assessment, management, appropriate teaching and counseling, and necessary follow-up or referral.
Abstract 18339: Glutathione S-Transferase P (GSTP) is a Critical Cardioprotective Protein in Heart Failure That Alleviates Apoptosis, Inflammation, and Cardiac Remodeling
Authors: Tariq Hamid, Guihua Zhou, Shang Z Guo, Justin R Kingery, Robert K Lewis, Daniel Conklin, Sanjay Srivastava, Sumanth D Prabhu
Journal: Circulation (2011)

Heart failure (HF) is characterized by increased lipid peroxidation products (e.g., unsaturated aldehydes) that amplify oxidative injury. Glutathione S-transferases (GSTs) metabolize electrophilic aldehydes by catalyzing their conjugation with glutathione. GSTs are central to antioxidant defense; however, their role in HF is unknown. Accordingly, we hypothesized that GSTP, the most abundant cardiac GST isoform, is a critical antioxidant and anti-inflammatory protein in HF. We examined left ventricular (LV) remodeling following coronary ligation (or sham-operation) in wild-type (WT) and GSTP-/- mice (n = 8-10/group). Echocardiography revealed no baseline cardiac phenotype in GSTP-/- mice. Compared to WT sham 4 wks after surgery, WT HF hearts exhibited significant (p &lt; 0.05): 1) LV dilatation (EDV 76 ± 33 vs 53 ± 2 μL) and systolic dysfunction (LVEF 51 ± 5 vs 67 ± 3 %); 2) hypertrophy (LV/tibia length [TL] 5.3 ± 1.0 vs 4.1 ± 0.3 mg/mm); 3) ∼30-40% downregulation of myocardial GSTP and GSTPA protein; 4) ∼4-fold increase in protein-acrolein adducts; 5) ∼3-fold increase in myocardial apoptosis by TUNEL staining; and 6) inflammatory activation as indexed by NF-κB DNA binding activity and mRNA levels of interleukin (IL)-1β and IL-6. In contrast, as compared to WT HF, GSTP-/- HF hearts had significant (p &lt; 0.05): 1) worsening of LV dilatation (LVEDV 112 ± 51 μL), systolic dysfunction (LVEF 37 ± 5 %), and wall thinning (anterior wall thickness [AWT] 0.47 ± 0.15 vs 0.57 ± 0.11 mm), but similar degrees of LV chamber hypertrophy; 2) augmentation of protein-acrolein adducts; 3) NF-κB activation, and 4) 2-5-fold increase in IL-1β and IL-6 expression. Importantly, GSTP-/- HF hearts also exhibited a ∼2-fold increase in apoptosis over WT HF, suggesting that differences in cell loss accounted for comparable degrees of chamber hypertrophy despite differences in LV dilatation. We conclude that there is decreased capacity for metabolizing toxic aldehydes in the failing heart with downregulation of GSTP and GSTA. GSTP plays a key cardioprotective role in HF, and alleviates pathological LV remodeling, inflammation, and apoptosis in the failing heart. GSTP-mediated cardioprotection may be in part related to its detoxification of reactive lipid peroxidation-derived aldehydes.
Management of Male Impotence.
Authors: M.D. Bennett, H Alan
Journal: Annals of Internal Medicine (1983)

Analyzing Research Data is de¬ signed as the second text in this two-volume set. Its purpose, the author states, is primarily to prevent the misuse of statistical procedures. That is a worthwhile goal; such misuse and the obfuscation that accompanies it should be prevented. Chapters include discussions of univariate distributions; testing of hy¬ potheses with nominal, ordinal, and continuous response variables; analy¬ sis of variance; evaluation of simple and multiple regression; presentation of a variety of more exotic multivariate analysis procedures; use of com¬ puter programs in statistical analy¬ sis; and the presentation of statistical data in research reports. As in the first text, the author draws examples from a variety of research areas, including the evalua¬ tion of birth control methods, detec¬ tion of sex discrimination, compari¬ son of uric acid levels in men and women, notation of the effects of anesthetics on arrhythmia in dogs, and evaluation of the relationship between age and forced expiratory volume in adults. In attempting to caution against the misuse of statistics, the author devotes considerable attention to lev¬ els of measurement. Levels of mea¬ surement are important, although the debates over whether data generated by lower-level measures can be appro¬ priately summarized by higher-level statistics have drawn attention from much more important issues of statis¬ tical methodology (Borgatta EF, Bohrnstedt GW: Level of measure¬ ment: Once over again, in Bohrnstedt G, Borgatta EF (eds): Social Measure¬ ment: Current Issues. Beverly Hills, Calif, Sage Publications Inc, 1981). For example, ignoring the structure of the errors in a statistical model may have a more pernicious impact on the drawing of substantive scien¬ tific conclusions than does the as¬ sumption that a dichotomous variable can be treated as if it were continu¬
Optimal safety profile and anticancer activity of NGRhTNF coupled with doxorubicin (NGR003 modified phase I combo trial)
Authors: G. Rizzardi, V. Gregorc, G. Vitali, C. Gallo Stampino, C. van Herpen, A. Santoro, A. Sobrero, K. Punt, F. Caligaris-Capio, C. Bordignon
Journal: Journal of Clinical Oncology (2007)

14056 Background: NGRhTNF is a vascular targeting agent (VTA) exploiting a tumour homing peptide (CNGRCG) selectively binding angiogenic vessels in solid tumors, where NGRhTNF specific binding relies on dynamic interactions with TNF-receptors and aminopeptidase N (CD13). NGRhTNF combines activity on tumour vascular permeability and direct anticancer activity. At low dose, NGRhTNF increases tumour vascular permeability. Consistently, mouse preclinical data indicate significant synergy between low dose NGRhTNF and cytotoxic agents. Thus, we tested NGRhTNF in combination with doxorubicin. Methods: 4 doses of NGRhTNF (0.2, 0.4, 0.8 and 1.6 μg/m 2 ) in combination with doxorubicin (75 mg/m 2 ) have been administered every 3 weeks in 15 patients.Main end- points included safety, anticancer activity and pharmacokinetic. Measurement of circulating tumour (CTC) and endothelial cells, sTNF receptors, along with plasma chemokine profile are being performed. Results: All patients were enrolled (5F/10M). Toxicity was limited to constitutional symptoms, most frequently chills. After a median follow-up of 12 weeks (range 3–28), 5 episodes of chills (1 grade I and 4 grade II) were reported in 4/15 patients.One episode of grade I hypertension was reported. Of note, the toxicity profile commonly-associated to doxorubicin has not been exacerbated. Stabilization of disease occurred in 10/15 patients lasting 13 weeks (range 6–28 with 5 patients still ongoing at December 2006). In addition, partial response was achieved in 2 patients, lasting 23 and 14 (still ongoing) weeks, respectively. It is worth noting that anticancer activity was observed in 12/15 patients of whom 9 had previously received anthracycline-containing regimens and 5 were anthracycline-resistant suggesting a role of NGRhTNF in inducing tumour sensitivity to doxorubicin. Finally, changes in CTC levels over time consistently matched the clinical outcome. Conclusions: Coupling NGRhTNF with doxorubicin induced anticancer activity along with an optimal safety profile in pretreated patients providing support for the phase II combination studies addressing diseases suitable for anthracycline treatment such as sarcoma and ovarian cancer, and planned to start in early 2007. No significant financial relationships to disclose.
The Effects on Women of Changing Conditions in the Cigar and Cigarette Industries.
Authors: Caroline Manning, Harriet A. Byrne
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal