tbuckley/cabot-search huggingface dataset:
Quantifying Disparities in Per- and Polyfluoroalkyl Substances (PFAS) Levels in Drinking Water from Overburdened Communities in New Jersey, 2019–2021
Authors: Rosie Mueller, Derrick Salvatore, Phil Brown, Alissa Cordner
Journal: Environmental Health Perspectives (2024)

Policymakers have become increasingly concerned regarding the widespread exposure and toxicity of per- and polyfluoroalkyl substances (PFAS). While concerns exist about unequal distribution of PFAS contamination in drinking water, research is lacking.
Thrombosis risk prediction in lymphoma patients: A m<scp>ulti‐institutional</scp>, retrospective model development and validation study
Authors: Shengling Ma, Jennifer La, Kaitlin N. Swinnerton, Danielle Guffey, Raka Bandyo, Giordana De Las Pozas, Katy Hanzelka, Xiangjun Xiao, Cristhiam M. Rojas‐Hernandez, Christopher I. Amos, Vipul Chitalia, Katya Ravid, Kelly W. Merriman, Christopher R. Flowers, Nathanael Fillmore, Ang Li
Journal: American Journal of Hematology (2024)

Venous thromboembolism (VTE) poses a significant risk to cancer patients receiving systemic therapy. The generalizability of pan-cancer models to lymphomas is limited. Currently, there are no reliable risk prediction models for thrombosis in patients with lymphoma. Our objective was to create a risk assessment model (RAM) specifically for lymphomas. We performed a retrospective cohort study to develop Fine and Gray sub-distribution hazard model for VTE and pulmonary embolism (PE)/ lower extremity deep vein thrombosis (LE-DVT) respectively in adult lymphoma patients from the Veterans Affairs national healthcare system (VA). External validations were performed at the Harris Health System (HHS) and the MD Anderson Cancer Center (MDACC). Time-dependent c-statistic and calibration curves were used to assess discrimination and fit. There were 10,313 (VA), 854 (HHS), and 1858 (MDACC) patients in the derivation and validation cohorts with diverse baseline. At 6 months, the VTE incidence was 5.8% (VA), 8.2% (HHS), and 8.8% (MDACC), respectively. The corresponding estimates for PE/LE-DVT were 3.9% (VA), 4.5% (HHS), and 3.7% (MDACC), respectively. The variables in the final RAM included lymphoma histology, body mass index, therapy type, recent hospitalization, history of VTE, history of paralysis/immobilization, and time to treatment initiation. The RAM had c-statistics of 0.68 in the derivation and 0.69 and 0.72 in the two external validation cohorts. The two models achieved a clear differentiation in risk stratification in each cohort. Our findings suggest that easy-to-implement, clinical-based model could be used to predict personalized VTE risk for lymphoma patients.
Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice
Authors: Jinge Zhou, Tianxi Ye, Yun Yang, Entao Li, Kaiyue Zhang, Yuping Wang, Shaohong Chen, Jiang Hu, Kai Zhang, Fang Liu, Rui Gong, Xia Chuai, Zefeng Wang, Sandra Chiu
Journal: Molecular Therapy (2024)
ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs
Authors: Ewa Sicinska, Vijaya S.R. Kola, Joseph A. Kerfoot, Madeleine L. Taddei, Alyaa Al-Ibraheemi, Yi-Hsuan Hsieh, Alanna J. Church, Esther Landesman-Bollag, Yosef Landesman, Matthew L. Hemming
Journal: Cancer Research (2024)

Abstract Alveolar soft part sarcoma (ASPS) is a rare mesenchymal malignancy driven by the ASPSCR1::TFE3 fusion. A better understanding of the mechanisms by which this oncogenic transcriptional regulator drives cancer growth is needed to help identify potential therapeutic targets. In this study, we characterized the transcriptional and chromatin landscapes of ASPS tumors and preclinical models, identifying the essential role of ASPSCR1::TFE3 in tumor cell viability by regulating core transcriptional programs involved in cell proliferation, angiogenesis, and mitochondrial biology. ASPSCR1::TFE3 directly interacted with key epigenetic regulators at enhancers and promoters to support ASPS-associated transcription. Among the effector programs driven by ASPSCR1::TFE3, cell proliferation was driven by high levels of cyclin D1 expression. Disruption of cyclin D1/CDK4 signaling led to a loss of ASPS proliferative capacity, and combined inhibition of CDK4/6 and angiogenesis halted tumor growth in xenografts. These results define the ASPS oncogenic program, reveal mechanisms by which ASPSCR1::TFE3 controls tumor biology, and identify a strategy for therapeutically targeting tumor cell–intrinsic vulnerabilities. Significance: The ASPSCR1::TFE3 fusion propels the growth of alveolar soft part sarcoma by activating transcriptional programs that regulate proliferation, angiogenesis, mitochondrial biogenesis, and differentiation and can be therapeutically targeted to improve treatment.
Characterization of the genetic determinants of context-specific DNA methylation in primary monocytes
Authors: James J Gilchrist, Hai Fang, Sara Danielli, Marketa Tomkova, Isar Nassiri, Esther Ng, Orion Tong, Chelsea Taylor, Dylan Muldoon, Lea R Z Cohen, Hussein Al-Mossawi, Evelyn Lau, Matt Neville, Benjamin Schuster-Boeckler, Julian C Knight, Benjamin P Fairfax
Journal: Cell Genomics (2024)
Combined emapalumab and ruxolitinib in patients with haemophagocytic Lymphohistiocytosis
Authors: Yue Song, Fei Zhou, Feng Du, Ziyan Wang, Liyun Bai, Yifang Yao, Limin Liu, Xiao Ma, Suning Chen, Depei Wu, Xuefeng He
Journal: Blood Cancer Journal (2024)
Antigenic distance between primary and secondary dengue infections correlates with disease risk
Authors: Lin Wang, Angkana T. Huang, Leah C. Katzelnick, Noémie Lefrancq, Ana Coello Escoto, Loréna Duret, Nayeem Chowdhury, Richard Jarman, Matthew A. Conte, Irina Maljkovic Berry, Stefan Fernandez, Chonticha Klungthong, Butsaya Thaisomboonsuk, Piyarat Suntarattiwong, Warunee Vandepitte, Stephen S. Whitehead, Simon Cauchemez, Derek A. T. Cummings, Henrik Salje
Journal: Science Translational Medicine (2024)

Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection even in previously exposed individuals. In addition, for some pathogens, such as dengue virus, poorly targeted immunity is associated with increased risk of severe disease through a mechanism known as antibody-dependent enhancement. However, it remains unclear whether the antigenic distances between an individual's first infection and subsequent exposures dictate disease risk, explaining the observed large-scale differences in dengue hospitalizations across years. Here, we develop a framework that combines detailed antigenic and genetic characterization of viruses with details on hospitalized cases from 21 years of dengue surveillance in Bangkok, Thailand, to identify the role of the antigenic profile of circulating viruses in determining disease risk. We found that the risk of hospitalization depended on both the specific order of infecting serotypes and the antigenic distance between an individual's primary and secondary infections, with risk maximized at intermediate antigenic distances. These findings suggest that immune imprinting helps determine dengue disease risk and provide a pathway to monitor the changing risk profile of populations and to quantifying risk profiles of candidate vaccines.
IL1R2 Blockade Alleviates Immunosuppression and Potentiates Anti-PD-1 Efficacy in Triple-Negative Breast Cancer
Authors: Jie Xia, Lixing Zhang, Xilei Peng, Juchuanli Tu, Siqin Li, Xueyan He, Fengkai Li, Jiankun Qiang, Haonan Dong, Qiaodan Deng, Cuicui Liu, Jiahui Xu, Rui Zhang, Quentin Liu, Guohong Hu, Chong Liu, Yi-Zhou Jiang, Zhi-Ming Shao, Ceshi Chen, Suling Liu
Journal: Cancer Research (2024)

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic options. IL1 receptor type 2 (IL1R2) promotes breast tumor-initiating cell (BTIC) self-renewal and tumor growth in TNBC, indicating that targeting it could improve patient treatment. In this study, we observed that IL1R2 blockade strongly attenuated macrophage recruitment and the polarization of tumor-associated macrophages (TAM) to inhibit BTIC self-renewal and CD8+ T-cell exhaustion, which resulted in reduced tumor burden and prolonged survival in TNBC mouse models. IL1R2 activation by TAM-derived IL1β increased PD-L1 expression by interacting with the transcription factor Yin Yang 1 (YY1) and inducing YY1 ubiquitination and proteasomal degradation in both TAMs and TNBC cells. Loss of YY1 alleviated the transcriptional repression of c-Fos, which is a transcriptional activator of PDL-1. Combined treatment with an IL1R2-neutralizing antibodies and anti-PD-1 led to enhanced antitumor efficacy and reduced TAMs, BTICs, and exhausted CD8+ T cells. These results suggest that IL1R2 blockade might be a strategy to potentiate immune checkpoint blockade efficacy in TNBC to improve patient outcomes. Significance: IL1R2 in both macrophages and breast cancer cells orchestrates an immunosuppressive tumor microenvironment by upregulating PD-L1 expression and can be targeted to enhance the efficacy of anti-PD-1 in triple-negative breast cancer.
Effect of optical diagnosis training on recognition and treatment of submucosal invasive colorectal cancer in community hospitals: a prospective multicenter intervention study
Authors: Lonne W.T. Meulen, Krijn J.C. Haasnoot, Marije S. Vlug, Frank H.J. Wolfhagen, Martine A.M.C. Baven-Pronk, Michael P.J.A. van der Voorn, Matthijs P. Schwartz, Lauran Vogelaar, Wouter H de Vos tot Nederveen Cappel, Tom C.J. Seerden, Wouter L. Hazen, Ruud W.M. Schrauwen, Lorenza Alvarez-Herrero, Ramon-Michel Schreuder, Annick B. van Nunen, Esther Stoop, Gijs J. de Bruin, Philip Bos, Willem A. Marsman, Edith Kuiper, Marc de Bièvre, Yasser A. Alderlieste, Robert Roomer, John Groen, Marloes Bigirwamungu-Bargeman, Peter D. Siersema, Sjoerd G. Elias, Ad A.M. Masclee, Leon M.G. Moons
Journal: Endoscopy (2024)

Recognition of submucosal invasive colorectal cancer (T1 CRC) is difficult, with sensitivities of 35 %-60 % in Western countries. We evaluated the real-life effects of training in the OPTICAL model, a recently developed structured and validated prediction model, in Dutch community hospitals.
Evolution of patients with Sézary syndrome after mogamulizumab discontinuation for any cause except progression: a multicenter retrospective study (Moga-stop study)
Authors: Sofia Tzoumpa, Saskia Ingen-Housz-Oro, Adèle de Masson, Anne Pham-Ledard, Tarik El Aarbaoui, Olivier Dereure, Gaëlle Quereux, Sarah Faiz, Marine de Vicq de Cumptich, Caroline Ram-Wolff, Raphaël Janela-Lapert, Emmanuella Guenova, Coralie Lheure, Yannick Le Corre, Henri Adamski, Maël Blanchard, Nathalie Bonnet, Florent Amatore, Florent Grange, Laura Troin, Martine Bagot, Marie Beylot-Barry
Journal: British Journal of Dermatology (2024)

The results of this study suggest that progressive discontinuation of mogamulizumab (Moga) should be considered once a response is obtained in patients with Sézary syndrome, even after a short treatment duration. This may minimize the risk of adverse effects, costs and resistance to Moga. Additionally, our study emphasizes that Moga rechallenge should be encouraged as a first choice in relapsing patients.
Growing the global cancer care system: success stories from around the world and lessons for the future
Authors: Edward Christopher Dee, C S Pramesh, Christopher M Booth, Fidel Rubagumya, Miriam Mutebi, Erin Jay G Feliciano, Michelle Ann B Eala, Giovanni G Cerri, Ophira Ginsburg, Bishal Gyawali, Fabio Ynoe de Moraes
Journal: JNCI Journal of the National Cancer Institute (2024)

Abstract Despite major biomedical advancements in various realms of oncology, the benefits of these developments are not equitably distributed, particularly in underresourced settings. Although much work has described the challenges and systemic barriers in global cancer control, in this article we focus on success stories. This article describes clinical care delivered at Rwanda’s Butaro Cancer Center of Excellence, the cancer research collaborations under India’s National Cancer Grid, and the efforts of Latin America’s Institute of Cancer of São Paulo in advancing cancer care and training. These examples highlight the potential of strategic collaborations and resource allocation strategies in improving cancer care globally. We emphasize the critical role of partnerships between physicians and allied health professionals, funders, and policy makers in enhancing access to treatment and infrastructure, advancing contextualized research and national guidelines, and establishing regional and global collaborations. We also draw attention to challenges faced in diverse global settings and outline benchmarks to measure success in the fight against cancer.
Transpiration‐Inspired Fabric Dressing for Acceleration Healing of Wound Infected with Biofilm
Authors: Zhicheng Zhang, Junjie Ma, Tao Xu, Tao Wang, Xueying Jia, Jiawei Lin, Chang Lv, Liang Cao, Yulong Ying, Lvlv Ji, Sheng Wang, Caiyun Fu
Journal: Advanced Healthcare Materials (2024)

Abstract In chronic wound management, efficacious handling of exudate and bacterial infections stands as a paramount challenge. Here a novel biomimetic fabric, inspired by the natural transpiration mechanisms in plants, is introduced. Uniquely, the fabric combines a commercial polyethylene terephthalate (PET) fabric with asymmetrically grown 1D rutile titanium dioxide (TiO 2 ) micro/nanostructures, emulating critical plant features: hierarchically porous networks and hydrophilic water conduction channels. This structure endows the fabric with exceptional antigravity wicking‐evaporation performance, evidenced by a 780% one‐way transport capability and a 0.75 g h −1 water evaporation rate, which significantly surpasses that of conventional moisture‐wicking textiles. Moreover, the incorporated 1D rutile TiO 2 micro/nanostructures present solar‐light induced antibacterial activity, crucial for disrupting and eradicating wound biofilms. The biomimetic transpiration fabric is employed to drain exudate and eradicate biofilms in Staphylococcus aureus ( S. aureus )‐infected wounds, demonstrating a much faster infection eradication capability compared to clinically common ciprofloxacin irrigation. These findings illuminate the path for developing high‐performance, textile‐based wound dressings, offering efficient clinical platforms to combat biofilms associated with chronic wounds.
Carbapenem use in extended-spectrum cephalosporin-resistant Enterobacterales infections in US hospitals and influence of IDSA guidance: a retrospective cohort study
Authors: Morgan K Walker, Guoqing Diao, Sarah Warner, Ahmed Babiker, Maniraj Neupane, Jeffrey R Strich, Christina Yek, Sameer S Kadri
Journal: The Lancet Infectious Diseases (2024)
Efficacy and immunogenicity following dengue virus-1 human challenge after a tetravalent prime-boost dengue vaccine regimen: an open-label, phase 1 trial
Authors: Kirsten E Lyke, Joel V Chua, Michael Koren, Heather Friberg, Gregory D Gromowski, Rekha R Rapaka, Adam T Waickman, Sudhaunshu Joshi, Kathleen Strauss, Michael K McCracken, Hernando Gutierrez-Barbosa, Biraj Shrestha, Christopher Culbertson, Paula Bernal, Rafael A De La Barrera, Jeffrey R Currier, Richard G Jarman, Robert Edelman
Journal: The Lancet Infectious Diseases (2024)
Why Latin America needs a regional Centre for Disease Control and Prevention
Authors: Patricia J Garcia, Jorge Saavedra, Laura Espinoza-Pajuelo, Fernando Ariel Garcia-Terron, Ximena Garzon, Adolfo Rubinstein, Enrique Paris, Martha Ospina, Milagros Guzmán-Acurio, Javier Guzmán
Journal: The Lancet (2024)
Assisted dying needs a thoughtful and engaged dialogue
Authors: None The Lancet
Journal: The Lancet (2024)

"It's simple and humane". Such was Emmanuel Macron's explanation of the title of France's new Aid in Dying bill, which aims to make it legal for adults with terminal illness to take lethal medication prescribed by a doctor. The wish to respect patient choice and alleviate suffering when all other options are exhausted is understandable, but the suggestion that anything related to assisted dying is simple is sorely misplaced.
Offline: It is time to take cancer more seriously
Authors: Richard Horton
Journal: The Lancet (2024)

The Lancet has published two Commissions in 2024 addressing the commonest cancers among men and women: prostate cancer (led by Nicholas James) and breast cancer (led by Charlotte Coles). As we were preparing these Commissions for publication, we considered writing an editorial linking the two cancers. But we hesitated. Surely these conditions are distinguished by their differences, not their similarities. Breast cancer is preventable. No such possibilities exist for prostate cancer. As our Commission on Prostate Cancer concluded: "The projected rise in prostate cancer cases cannot be prevented by lifestyle changes or public health interventions." Yet, observing their launches and listening to the debates they provoked suggests that these cancers have more in common than might be appreciated—synergies that have important implications for accelerating cancer prevention and control.
The Visual Systems of Zebrafish
Authors: Herwig Baier, Ethan K. Scott
Journal: Annual Review of Neuroscience (2024)

The zebrafish visual system has become a paradigmatic preparation for behavioral and systems neuroscience. Around 40 types of retinal ganglion cells (RGCs) serve as matched filters for stimulus features, including light, optic flow, prey, and objects on a collision course. RGCs distribute their signals via axon collaterals to 12 retinorecipient areas in forebrain and midbrain. The major visuomotor hub, the optic tectum, harbors nine RGC input layers that combine information on multiple features. The retinotopic map in the tectum is locally adapted to visual scene statistics and visual subfield–specific behavioral demands. Tectal projections to premotor centers are topographically organized according to behavioral commands. The known connectivity in more than 20 processing streams allows us to dissect the cellular basis of elementary perceptual and cognitive functions. Visually evoked responses, such as prey capture or loom avoidance, are controlled by dedicated multistation pathways that—at least in the larva—resemble labeled lines. This architecture serves the neuronal code's purpose of driving adaptive behavior.
Inflammation‐Responsive Hydrogel Accelerates Diabetic Wound Healing through Immunoregulation and Enhanced Angiogenesis
Authors: Fang He, Pengqin Xu, Zhikang Zhu, Ying Zhang, Chenghao Cai, Yuxiang Zhang, Jiaming Shao, Fang Jin, Qiong Li, Jiahuan You, Hanlei Zhou, Wei Zhang, Jintao Wei, Xudong Hong, Zhongtao Zhang, Chunmao Han, Yuqi Zhang, Zhen Gu, Xingang Wang
Journal: Advanced Healthcare Materials (2024)

Angiogenesis is a prominent component during the highly regulated process of wound healing. The application of exogenous vascular endothelial growth factor (VEGF) has shown considerable potential in facilitating angiogenesis. However, its effectiveness is often curtailed due to chronic inflammation and severe oxidative stress in diabetic wounds. Herein, an inflammation-responsive hydrogel incorporating Prussian blue nanoparticles (PBNPs) is designed to augment the angiogenic efficacy of VEGF. Specifically, the rapid release of PBNPs from the hydrogel under inflammatory conditions effectively alleviates the oxidative stress of the wound, therefore reprogramming the immune microenvironment to preserve the bioactivity of VEGF for enhanced angiogenesis. In vitro and in vivo studies reveal that the PBNPs and VEGF co-loaded hydrogel is biocompatible and possesses effective anti-inflammatory properties, thereby facilitating angiogenesis to accelerate the wound healing process in a type 2 diabetic mouse model.
Learning, Fast and Slow: Single- and Many-Shot Learning in the Hippocampus
Authors: Zhenrui Liao, Attila Losonczy
Journal: Annual Review of Neuroscience (2024)

The hippocampus is critical for memory and spatial navigation. The ability to map novel environments, as well as more abstract conceptual relationships, is fundamental to the cognitive flexibility that humans and other animals require to survive in a dynamic world. In this review, we survey recent advances in our understanding of how this flexibility is implemented anatomically and functionally by hippocampal circuitry, during both active exploration (online) and rest (offline). We discuss the advantages and limitations of spike timing–dependent plasticity and the more recently discovered behavioral timescale synaptic plasticity in supporting distinct learning modes in the hippocampus. Finally, we suggest complementary roles for these plasticity types in explaining many-shot and single-shot learning in the hippocampus and discuss how these rules could work together to support the learning of cognitive maps.
Seven-year outcomes of venetoclax-ibrutinib therapy in mantle cell lymphoma: durable responses and treatment-free remissions
Authors: Sasanka M. Handunnetti, Mary Ann Anderson, Kate I Burbury, Philip A Thompson, Glenda Burke, Mathias Bressel, Juliana L Di Iulio, Rodney John Hicks, David A Westerman, Stephen Lade, Christiane Pott, Rishu Agarwal, Rachel M Koldej, David Ritchie, Martin Dreyling, Mark A. Dawson, Sarah-Jane Dawson, John F. Seymour, Andrew W Roberts, Constantine S. Tam
Journal: Blood (2024)
Radiation Therapy With or Without Cisplatin for Local Recurrences of Endometrial Cancer: Results From an NRG Oncology/GOG Prospective Randomized Multicenter Clinical Trial
Authors: Ann H. Klopp, Danielle Enserro, Matthew Powell, Marcus Randall, Julian C. Schink, Robert S. Mannel, Laura Holman, David Bender, Christina L. Kushnir, Floor Backes, Susan L. Zweizig, Steven Waggoner, Kristin A. Bradley, Lana DeSouza Lawrence, Parviz Hanjani, Christopher J. Darus, William Small, Higinia R. Cardenes, Jonathan M. Feddock, David S. Miller
Journal: Journal of Clinical Oncology (2024)

PURPOSE Pelvic recurrence is a frequent pattern of relapse for women with endometrial cancer. A randomized trial compared progression-free survival (PFS) after treatment with radiation therapy alone as compared with concurrent chemotherapy. MATERIALS AND METHODS Between February 2008 and August 2020, 165 patients were randomly assigned 1:1 to receive either radiation treatment alone or a combination of chemotherapy and radiation treatment. The primary objective of this study was to determine whether chemoradiation therapy was more effective than radiation therapy alone at improving PFS. RESULTS The majority of patients had low-grade (1 or 2) endometrioid histology (82%) and recurrences confined to the vagina (86%). External beam with either the three-dimensional or intensity modulated radiation treatment technique was followed by a boost delivered with brachytherapy or external beam. Patients randomly assigned to receive chemotherapy were treated with once weekly cisplatin (40 mg/m 2 ). Rates of acute toxicity were higher in patients treated with chemoradiation as compared with radiation treatment alone. Median PFS was longer for patients treated with radiation therapy alone as compared with chemotherapy and radiation (median PFS was not reached for RT v 73 months for chemoradiation, hazard ratio of 1.25 (95% CI, 0.75 to 2.07). At 3 years, 73% of patients treated definitively with radiation and 62% of patients treated with chemoradiation were alive and free of disease progression. CONCLUSION Excellent outcomes can be achieved for women with localized recurrences of endometrial cancer when treated with radiation therapy. The addition of chemotherapy does not improve PFS for patients treated with definitive radiation therapy for recurrent endometrial cancer and increases acute toxicity. Patients with low-grade and vaginal recurrences who constituted the majority of those enrolled are best treated with radiation therapy alone.