tbuckley/cabot-search huggingface dataset:
Abstract 2234: Value of Multi-Detector Computed Tomography Evaluation of Myocardial Perfusion in the Assessment of Ischemic Heart Disease: Comparison with Nuclear Perfusion Imaging
Authors: Nadjia Kachenoura, Joseph A Lodato, Tamar Gaspar, Dianna M Bardo, Barbara Newby, Sarah Gips, Nathan Peled, Roberto M Lang, Victor Mor-Avi
Journal: Circulation (2008)

While CT coronary angiography (CTCA) is gaining acceptance as a diagnostic technique, MDCT derived myocardial perfusion has not been validated against an accepted reference standard. We sought to develop a technique for quantitative assessment of myocardial perfusion from MDCT images, and investigate the diagnostic value of resting MDCT perfusion in comparison with SPECT myocardial perfusion imaging (MPI). We studied 98 consecutive patients undergoing CTCA who also had MPI. 20 patients with normal MPI were used as controls. MDCT perfusion was measured in 16 segments in terms of x-ray attenuation. Abnormal resting perfusion was detected by comparison against normal values obtained in the control group. Accuracy of detection was determined against resting MPI on a segment, vascular territory and patient basis. To determine the causes of resting perfusion defects detected by MDCT but not confirmed by resting MPI, stress MPI data were used. Perfusion abnormalities were detected by resting MPI in 36/78 patients in 58 vascular territories. MDCT detected these abnormalities in 31/36 patients (sensitivity 0.86). Abnormalities found in additional 28/78 patients were not confirmed by resting MPI (specificity 0.33). However, 23 of these 28 apparently false positive resting MDCT perfusion tests (82%) were associated with abnormal stress MPI. In the majority of these 23 patients (16 or 70%), the quality of MDCT images was optimal, while in the remaining 5/28 patients with resting MDCT perfusion abnormalities that were not confirmed by stress MPI, 4 (80%) had suboptimal images. Resting MDCT can accurately detect perfusion abnormalities in agreement with resting MPI. Moreover, the majority of abnormalities not confirmed by resting MPI were associated with stress-induced ischemia. Therefore, myocardial perfusion assessment, even at rest, is a potentially valuable addition to MDCT tools for noninvasive evaluation of coronary artery disease without additional radiation or contrast load, which promises not only to improve the diagnostic accuracy of cardiac CT, but is also likely to prove as a cost-effective, single-stop alternative to costly serial testing.
Abstract 3113: Uncontrolled Hypertension, Systolic and Diastolic Blood Pressure and Development of Symptomatic Peripheral Arterial Disease in the Women’s Health Study
Authors: Tiffany M Powell, Robert J Glynn, Mark A Creager, Paul M Ridker, Aruna D Pradhan
Journal: Circulation (2007)

Background : Prospective data pertaining to risk factors for peripheral arterial disease (PAD) in women are sparse. Few studies have evaluated blood pressure, including uncontrolled hypertension, and PAD onset in women. Methods and Results : We examined the relationship between blood pressure and development of confirmed symptomatic PAD (n=116 events) in a prospective cohort study of 39,261 female health professionals aged ≤ 45 years without diagnosed vascular disease at baseline. Median follow-up was 11.4 years. Women were first grouped according to baseline presence of uncontrolled hypertension, defined as reported systolic blood pressure (SBP)≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg, and pharmacologic treatment status. SBP and DBP were then modeled as continuous and categorical exposures irrespective of treatment status. Pulse pressure (PP) and mean arterial pressure (MAP) were also assessed. Age-adjusted and multivariable-adjusted risk estimates were derived from Cox proportional hazards models. Women with treated but uncontrolled hypertension had the highest risk of symptomatic PAD (0.67 events per 1000 person-years). Adjusted hazard ratios (HRs) compared to women without hypertension were 1.1 (95% CI, 0.5–2.3) for women who were treated and controlled, 1.7 (95% CI, 1.0 –3.0) for women untreated and uncontrolled, and 2.3 (95% CI, 1.4 – 4.0) for women treated and uncontrolled (p-trend&lt;0.001). When hypertension was examined using continuous and categorical measures, there was a 33% increase in risk per 10 mmHg of SBP (95% CI, 18 to 47%) and a positive gradient in multivariable-adjusted risk according to SBP category (&lt;120, 120 –139, 140 –159, and ≤ 160 mmHg); HRs were 1.0, 1.6, 2.8, and 4.3 (p-trend&lt;0.001), respectively. We also considered DBP, PP, and MAP. While individually predictive, none was a stronger predictor than SBP with none adding predictive ability beyond SBP. Conclusions : Uncontrolled hypertension is associated with incident symptomatic PAD in women. Among blood pressure variables assessed, SBP is the best single predictor. These data support a strong prognostic role for systolic blood pressure in the development of peripheral atherosclerosis in women.
Abstract 230: A Marker of Resuscitation Outcome in Patients Who Were Treated With Extracorporeal Cardiopulmonary Resuscitation After Out-of-Hospital Cardiac Arrest Failed.
Authors: Kazuhiro Watanabe, Ken Nagao, Kimio Kikushima
Journal: Circulation (2010)

Backgraund: Since 1996, we performed E-CPR (PCPS, coronary reperfusion therapy and hypothermia) in patients who arrived at the ER in cardiac arrest and failed to respond to standard CPR. However, f...
Irish government asked to pay obstetricians' insurance premiums.
Authors: Doug Payne
Journal: BMJ (2001)

The Medical Defence Union has asked the Irish government to insure in full the country's obstetricians; otherwise the doctors could face a huge increase in their insurance bills. Premiums are predicted to rise to £Ir350 000 (£281 000; $422 000) from July and doctors are expected to pay between a tenth and a fifth of the bill.

The government pays 80-90% of the current premium (as much as £Ir68 000) for the 90 consultant obstetricians working in public hospitals. The union said that it had approached other insurers in Ireland and elsewhere “but they cannot be persuaded to underwrite the risks of obstetric and gynaecological practice in Ireland.”

The union's assessment was backed by the …
A Prospective Randomized Trial of Drug-Eluting Balloons Versus Everolimus-Eluting Stents in Patients With In-Stent Restenosis of Drug-Eluting Stents
Authors: Fernando Alfonso, María Jose Pérez-Vizcayno, Alberto Cárdenas, Bruno García del Blanco, Arturo García-Touchard, José Ramón López-Minguéz, Amparo Benedicto, Mónica Masotti, Javier Zueco, Andrés Iñiguez, Maite Velázquez, Raúl Moreno, Vicente Mainar, Antonio Domínguez, Francisco Pomar, Rafael Melgares, Fernando Rivero, Pilar Jiménez-Quevedo, Nieves Gonzalo, Cristina Fernández, Carlos Macaya
Journal: Journal of the American College of Cardiology (2015)
SCHÜLLER-CHRISTIAN'S DISEASE; REPORT OF A CASE IN ONE OF IDENTICAL TWINS
Authors: A. B. Jones
Journal: Annals of Internal Medicine (1939)

Case Reports1 December 1939SCHÜLLER-CHRISTIAN'S DISEASE; REPORT OF A CASE IN ONE OF IDENTICAL TWINSA. B. JONES, F.A.C.P.A. B. JONES, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-6-1068 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSchüller-Christian's disease is a constitutional metabolic disorder. It does not appear to be familial nor hereditary. Identical twins have identical heredity and, barring intrauterine and birth accidents, are born with identical constitutions. Theoretically, they should be equally susceptible to disease and under the same environmental conditions should have the same illnesses with equal severity at the same time. Judging from the reports appearing in the literature this seems to be the case. With rare exceptions in all the cases reported in which a disease has occurred in one identical twin, the same disease has occurred approximately simultaneously in the other.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Med. Corps U. S. Army Schofield Barracks, T. H.*Received for publication July 9, 1938.From the Medical Service, Letterman General Hospital, San Francisco, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNichtentzündliche Erkrankungen des UnterhautbindegewebesStudy of Consanguinity in Twenty-one Gases of Hand-Schüller-Christian Disease (Systemic Reticuloendothelial Granuloma)Carcinoma of the cervix uteri in identical twins 1 December 1939Volume 13, Issue 6Page: 1068-1075KeywordsBirthHeredityMedical servicesMetabolic disordersMonozygotic twins Issue Published: 1 December 1939 PDF DownloadLoading ...
INFANTILE CEREBRAL PALSY; ITS TREATMENT BY SELECTIVE INHIBITION OF SENSORY STIMULI
Authors: Earl R. Carlson
Journal: Annals of Internal Medicine (1937)

Article1 August 1937INFANTILE CEREBRAL PALSY; ITS TREATMENT BY SELECTIVE INHIBITION OF SENSORY STIMULIEARL R. CARLSON, M.D.EARL R. CARLSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-2-324 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen the nervous system has been damaged by disease or injury at birth and choreo-athetosis, spasticity, ataxia or some other type of hyperkinesia is present, the tendency in prescribing treatment is to place too much emphasis on physical training without due consideration of the effect that repetition of an activity has upon the growth of the behavior pattern at various stages of development. Stepping movements, for example, show themselves almost immediately at birth but no amount of exercise is going to enable the normal infant to walk until his nervous system has attained adequate differentiation. In the case of the...Bibliography BRICKNERLYONS RMVL: Studies on individually acquired automatic associated movements, Bull. Neurol. Inst., New York, Vol. 2, 1932. Google Scholar CARLSONKLINGMAN ERWO: Observations on factors inhibiting choreoathetosis, Bull. Neurol. Inst. New York, Vol. 5, August 1936. Google Scholar DYKEDAVIDOFFMASSON CGLMCB: Cerebral hemiatrophy with homolateral hypertrophy of skull and sinuses, Surg., Gynec. and Obst., 1933, lvii, 588-600. Google Scholar DYKEDAVIDOFF CGLM: Demonstration of normal cerebral structures by means of encephalography; subarachnoid cisterns and their contents, Bull. Neurol. Inst. New York, 1934, iii, 418-445. Recent advances in encephalography, Radiology, 1934, xxii, 461-474. Google Scholar MCGRAW MB: Growth, a study of Johnny and Jimmy, 1935, D. Appleton-Century Co., New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York*Delivered in part before the General Sessions, American College of Physicians, Detroit, March 2, 1936. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byResearch on Effects of Color Reversal on the Visual Perceptual and Visuomotor Performances of Spastic Cerebral Palsied and other Exceptional IndividualsEffects of Color Reversal of Figure and Ground Drawing Materials on Drawing PerformanceThe Influence of Rhythmic Drumbeat Stimuli Upon the Pulse Rate and General Activity of Long-Term SchizophrenicsCerebral PalsyInfantile Cerebral Palsy 1 August 1937Volume 11, Issue 2Page: 324-334KeywordsAtaxiaBehaviorBirthCerebral palsyExerciseInfantsNervous system Issue Published: 1 August 1937 PDF downloadLoading ...
Abstract 264: CPR Quality is More Variable at Night Than During the Day in a Multicenter Study of in-hospital Cardiac Arrest.
Authors: Sarah M Perman, Douglas A Smith, Marion Leary, Lance B Becker, Noah J Swann, Trevor C Yuen, Dana P Edelson, Benjamin S Abella
Journal: Circulation (2010)

Background: Recent work has shown that survival from in-hospital cardiac arrest (IHCA) is higher during the day than at night, especially in the ward setting (outside of the ICU). The reasons for this outcome variation remain unclear. High quality CPR has been shown to confer survival benefit from cardiac arrest; it is unknown whether CPR quality varies during IHCA between day and night.

Objective: We hypothesized that CPR quality (as measured by compression rate, depth and pre/post shock pauses) would be higher and less variable during the day than at night in ward IHCA events.

Methods: We examined consecutive adult IHCAs at three study hospitals from 4/2006–5/2010. Time of arrest was dichotomized as day (7:00 AM–10:59 PM) or night (11:00 PM–6:59 AM) following previously published definitions. Quality of CPR was assessed by quantifying chest compression rate, depth, and duration of pre-and post-shock pauses via CPR-recording monitor/defibrillators. Data were analyzed using standard descriptive and comparative statistics.

Results: Data were collected from 820 IHCAs of which 173 occurred on inpatient wards. In this ward subset, mean subject age was 66±15 years, and 47% were male. Survival to discharge in this subset was 15%. Mean chest compression rate was lower at night compared to day (101.6±16.1 per min vs.106.6±6.5 per min; p=.002) with a significantly larger compression rate variance at night (p<0.001). There was a trend towards increasing compression depth during day (47.9±8.6 mm vs 45.6±8.7 mm; p=NS). Daytime events had shorter mean pre-shock pauses (11.9± 18.0 sec vs 15.8±15.4 sec; p=NS) and shorter post-shock pauses (2.8±1.8 sec vs 4.6±5.0 sec; p=0.042) with a statistically significant post-shock pause variance (p<0.001). There was a small trend towards lower post-arrest survival at night compared to day (14.0% vs 15.5%, p=NS).

Conclusions: Resuscitation efforts occurring at night on hospital wards exhibit lower and more variable chest compression rates, as well as increased pre-and post-shock pause times, compared to IHCA resuscitation care during the day. This variation may partially explain the clinical survival difference measured in previous investigations, and has implications for hospital staffing and training to improve IHCA outcomes.
The Effect of Age on Clinical Outcomes and Health Status
Authors: Sheng-Chia Chung, Mark A. Hlatky, David Faxon, Kodangudi Ramanathan, Dale Adler, Arshag Mooradian, Charanjit Rihal, Roslyn A. Stone, Joyce T. Bromberger, Sheryl F. Kelsey, Maria Mori Brooks
Journal: Journal of the American College of Cardiology (2011)
VITAMINS IN THEORY AND PRACTICE
Authors: Howard B. Lewis
Journal: Annals of Internal Medicine (1939)

Article1 November 1939VITAMINS IN THEORY AND PRACTICEHOWARD B. LEWIS, PH.D.HOWARD B. LEWIS, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-5-749 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOur conception of the vitamins has undergone material change since the term was introduced into the literature of the biological sciences and medicine by Casimir Funk in 1912. In an important review of the existing knowledge of beri-beri, scurvy, and pellagra, he emphasized the reality of the deficiency diseases and suggested the term "vitamine" for the factors, as yet poorly characterized, which were effective in the cure or prevention of these conditions. The term was intended to suggest their vital function (vita, life) and basic nature (amine, a basic compound containing nitrogen). Since early investigations failed to support Funk's contention... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HOWARD B. LEWIS, PH.D.Affiliations: Ann Arbor, Michigan*Read at the New Orleans meeting of the American College of Physicians March 27, 1939.From the Department of Biological Chemistry, Medical School, University of Michigan. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1939Volume 13, Issue 5 Page: 749-754 Keywords Vitamins ePublished: 1 December 2008 Issue Published: 1 November 1939 Copyright & PermissionsCopyright, 1939, by The American College of PhysiciansPDF downloadLoading ...
Abstract 2891: Reversible Pulmonary Hypertension has Comparable Survival - Analysis of 10331 Heart Transplant Recipients in Recent Era
Authors: Lois U Nwakanma, Eric S Weiss, Nishant D Patel, William A Baumgartner, Stuart D Russell, John V Conte
Journal: Circulation (2007)

Background: Conflicting data exist regarding the impact of reversible pulmonary hypertension (PHTN) on post-transplant outcomes. We sought to determine how reversible PHTN affects survival in a large cohort of heart transplant recipients. Methods: A retrospective cohort study of United Network for Organ Sharing (UNOS) data from January 1, 2000 to December 31, 2006 was performed. Based on the amount of pulmonary vascular resistance (PVR) at initial listing and the most recent PVR prior to transplant, patients were stratified into 3 groups (Normal -PVR always &lt; 2.5 Wood units, Reversible - PVR initially &gt; 2.5, but &lt; 2.5 prior to transplant, Fixed - PVR always &gt; 2.5) and survival post transplant was analyzed. Results: Data was available on 10331 recipients. Of those patients, 3886 (37.6%) patients were classified as Normal, 1621 (15.7%) were Reversible, and 4824 (46.7%) had Fixed PHTN. Among the fixed group, PHTN was severe in 1989 patients (PVR &gt;=5). Kaplan-Meier survival was comparable by log rank test between the normal and reversible groups (p&gt;0.05) but was significantly worse for the fixed group (p&lt;0.001). Sub-analysis of patients with initial PVR&gt;=5 in the reversible group also had comparable survival to the normal group. These survival results were confirmed in a propensity-adjusted multivariate Cox regression analysis, controlling for clinically relevant co-founders. Furthermore, similar results were obtained using PVR of 2.5 or 5 as the cut-off points. Conclusions: The UNOS database has provided the largest number of patients analyzed by PVR. Reversible pulmonary hypertension has comparable post-transplant survival regardless of initial severity.
RUPTURE OF THE SPLEEN DUE TO TULAREMIA: REPORT OF A CASE
Authors: E B WELLS, C TILLMAN
Journal: Annals of Internal Medicine (1946)

Case Reports1 November 1946RUPTURE OF THE SPLEEN DUE TO TULAREMIA: REPORT OF A CASEE. BUIST WELLS, M.D., CLIFFORD TILLMAN, M.D.E. BUIST WELLS, M.D.Search for more papers by this author, CLIFFORD TILLMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-5-852 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONRupture of the spleen as one of the manifestations or complications of tularemia apparently has rarely if ever before been encountered. A thorough search of the literature reveals no recorded instance of this nature. A patient was recently observed at Vanderbilt University Hospital in whom this condition was found at autopsy following a clinical course in which the exact diagnosis remained obscure. Because of its unusual nature a report of this case seems justified.CASE REPORTHistory. A 41 year old white male farmer was admitted to the medical service of Vanderbilt University Hospital on December 18, 1944 with...Bibliography1. RANSMEIEREWING JCCL: The agglutination reaction in tularemia, Jr. Infect. Dis., 1941, lxix, 193-205. CrossrefGoogle Scholar2. KENNEDY JA: Pulmonary tularemia, Jr. Am. Med. Assoc., 1942, cxviii, 781-787. CrossrefGoogle Scholar3. FOSHAY L: Tularemia: A summary of certain aspects of the disease including methods for early diagnosis and the results of serum treatment in 600 patients, Medicine, 1940, xix, 1-83. CrossrefGoogle Scholar4. GOODPASTUREHOUSE EWSJ: The pathologic anatomy of tularemia in man, Am. Jr. Path., 1928, iv, 213-226. Google Scholar5. FRANCIS E: The pathology of tularemia, Natl. Inst. Health, Bull. No. 167, 1937, Washington. Google Scholar6. Intrathoracic changes in tularemia, Med. Bull. Vet. Admin., 1934, xi, 77-83. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nashville, Tennessee*Received for publication July 31, 1945.From the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Rare Case of Spontaneous Splenic Rupture Secondary to Tularemia Following a Cat BiteAcute lymphocytic leukaemia presenting as spontaneous splenic ruptureAcute Leukemia with Rupture of the Spleen as the Initial Symptom 1 November 1946Volume 25, Issue 5Page: 852-859KeywordsAutopsyMedical servicesSpleenTularemia ePublished: 1 December 2008 Issue Published: 1 November 1946 PDF downloadLoading ...
Abstract 15217: The Influence of Patient Characteristics on Treatment Outcome of Bone Marrow Cell Injection in Patients with Chronic Myocardial Ischemia
Authors: Sander Rodrigo, Jan van Ramshorst, Saskia L Beeres, Petra Dibbets-Schneider, Albert de Roos, Willem E Fibbe, Jaap J Zwaginga, Ernst E van der Wall, Martin J Schalij, Jeroen J Bax, Douwe E Atsma
Journal: Circulation (2011)

Background: Clinical studies have demonstrated mixed results on treatment outcome of bone marrow cell (BMC) injection in patients with chronic myocardial disease. It is unclear whether patient char...
Day 30 Platelet Count As a Prognostic Marker of Survival in Acute Myeloid Leukemia
Authors: Abhishek Mangaonkar, Jamal Mohsin, Joshua Mansour, Ashis Mondal, Ravindra B. Kolhe, Anand Jillella, Vamsi Kota, Haarika Puttagunta
Journal: Blood (2014)