tbuckley/cabot-search huggingface dataset:
Abstract 007: Treadmill Duration Predicts Cognitive Function
Authors: Na Zhu, David R Jacobs, Pamela J Schreiner, R. Nick Bryan, Lenore J Launer, Rachel Whitmer, Stephen Sidney, Ellen W Demerath, William Thomas, Claude Bouchard, Ka He
Journal: Circulation (2012)

Evidence is scarce for an association between treadmill performance and cognitive function in healthy young and middle-aged adults. We assessed the hypothesis that duration on treadmill predicts cognitive function 25 years later. Participants were from the population-based Coronary Artery Risk Development in Young Adults (CARDIA) study, a multi-center study of black and white men and women aged 18-30 at recruitment in 1985-86 (year 0). The main independent variable of interest was baseline symptom-limited maximal treadmill test duration as a measure of treadmill performance potential, including its major subcomponent cardiorespiratory fitness (CRF/TPP). Cognitive functions measured were verbal memory (with the Rey auditory-verbal learning (AVLT)), psychomotor speed (Digit Symbol Substitution Test (DSST)) and executive function (modified Stroop interference test, where lower is better). We analyzed 2444 participants who had y0 treadmill testing and y25 cognitive testing. For each additional SD of treadmill duration (2.8 minutes), the DSST was 2.4 digits correctly substituted higher, the AVLT was 0.36 words recalled higher, and the Stroop test time 1.7 seconds less, after accounting for race, sex, age, highest attained education level and center of clinic visit( Table ). Further adjustment for dietary pattern, physical activity, smoking, BMI, alcohol consumption, glomerular filtration rate, blood pressure, cholesterol and diabetes status yielded similar trends for these cognitive function tests. In conclusion, CRF/TPP predicts cognitive function 25 years later independently of other factors among apparently healthy adults. Prospective estimation of cognitive function by treadmill duration at baseline in minimally and fully adjusted model (see text for details), N=2444. Year 25 Digit Symbol Substitution Test: Digits correctly substituted mean±SD: 70.1±15.9 Year 25 Rey Auditory-Verbal Learning Test: Words correctly recalled mean±SD: 8.3±3.3 Year 25 Stroop Test : Seconds to correctly name colors mean±SD: 43.9±12.8 Slope * SE P Slope * SE P Slope * SE P Year 0 treadmill duration (SD) mean±SD: 10.0±2.8 minutes Minimally adjusted 2.4 0.36 &lt;.0001 0.36 0.08 &lt;.0001 -1.7 0.31 &lt;.0001 Fully adjusted 2.3 0.45 &lt;.0001 0.39 0.08 &lt;.0001 -1.2 0.39 0.001 * “Slope” is the difference in the indicated cognitive function per SD (2.8 minutes) of treadmill duration.
Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms
Authors: L T Anderson, M Campbell, D M Grega, R Perry, A M Small, W H Green
Journal: American Journal of Psychiatry (1984)

In this double-blind, placebo-controlled study the administration of haloperidol resulted in significant decreases in behavioral symptoms and in general clinical improvement in 40 autistic children ages 2.33 to 6.92 years. Haloperidol also produced greater facilitation and retention of discrimination learning in the laboratory. No adverse effects were observed at therapeutic doses, which ranged from 0.5 to 3.0 mg/day or 0.019 to 0.217 mg/kg per day.
Abstract 11324: Clinical Efficacy of Treatment of Coronary in-Stent Restenosis with Drug Eluting Balloon Catheter — New Standard of Care?
Authors: Hong Yuan Xia, Adrian Fatt Heo Low, Chi-Hang Lee, Swee Guan Teo, Mark Chan, Koo Hui Chan, Huay Cheem Tan
Journal: Circulation (2010)

Background: Coronary in-stent restenosis (ISR) remains an Achilles' heel of percutaneous coronary intervention (PCI) even in the drug-eluting stent era, where repeat percutaneous treatment often re...
Abstract 3166: Blood Transfusion and Clinical Outcomes in Patients with Acute Myocardial Infarction
Authors: Doron Aronson, Michael Kapeliovich, Walter Markiewicz, Haim Hammerman
Journal: Circulation (2007)

Introduction: The safety of red blood cells transfusion (RBC-T) in patients (pts) with acute coronary syndromes is controversial, with some studies suggesting that RBC-T may adversely affect outcome. Methods: We studied the relationship between RBC-T during hospitalization and 6-months mortality in 2325 pts with acute myocardial infarction (AMI).Propensity score for RBC-T was calculated based on a logistic regression model incorporating age, sex, baseline hemoglobin (Hb), creatinine, diabetes, smoking, blood pressure and heart rate, Killip class, thrombolytic therapy and coronary interventions. The association between RBC-T and mortality was assessed using Cox mode with RBC-T as a time-dependent covariate, adjusting for the propensity to receive RBC-T and nadir Hb prior to RBC-T. Results: One hundred and ninety one pts (8.2%) received RBC-T. Median nadir Hb was markedly lower in pts receiving RBC-T (8.8 gr/dL [interquartile range 8.2–9.3]) compared with pts not receiving RBC-T (12.8 gr/dL [interquartile range 11.6 –13.9]; P &lt; 0.0001). Mortality increased progressively in pts receiving RBC-T over the 6-months follow-up (Figure ). The unadjusted hazard ratio (HR) for mortality in pts receiving RBC-T was 4.1 (95% CI 3.0 –5.7, P &lt; 0.0001). The effect of RBC-T was attenuated but remained significant after adjustments for the propensity to receive RBC-T (HR 2.1; 95% CI 1.4 –3.2, P &lt; 0.0001). However, after adjusting for nadir Hb, the association between RBC-T and mortality was not significant (HR 1.4; 95% 0.9 –2.1, P = 0.09). Conclusion: The transfusion-associated risk in patients with AMI reflects the severity of the anemia at the time of transfusion and associated comorbidities.
Abstract 15717: Acute On/Off Effects of Baroreceptor Activation Therapy (BAT) on Blood Pressure After Long-Term Therapy for Resistant Hypertension: Single-Center Experience With the Barostim Neo System
Authors: Tilman Hickethier, Marcel Halbach, Navid Madershahian, Mathias C Brandt, Uta Hoppe, Ralf Velden, Eric Lovett, Jochen Mueller-Ehmsen
Journal: Circulation (2013)

Background: Nonpharmacologic therapies have recently become available that can lower blood pressure (BP) when medical therapy is not sufficient. Chronic baroreceptor activation therapy (BAT) has been shown to reduce BP for at least 6 months using the Barostim neo system, which allows unilateral stimulation with a minimally invasive implantation. However, it is not known whether long-term chronic baroreceptor stimulation influences the acute responsiveness to stimulation. Therefore we determined the on/off effects of BAT at different time points after implantation.

Methods: Resistant HTN patients (n=12) were enrolled in an open-label, single-arm evaluation of Barostim neo after exclusion of secondary hypertension. Initial eligibility criteria for barostim implantation were systolic BP ≥ 140mmHg despite stable (≥ 4 weeks) medical therapy consisting of ≥ 3 antihypertensive drugs including at least one diuretic. For on/off testing three BP measurements were performed between 1 and 25 months after activation (mean 13.6 months): after 5 min rest with activated device, 5 min after deactivation of the device and 5 min after reactivation of the device.

Results: Before BAT mean office cuff BP was 178.2 ± 26.6 mmHg (systolic BP; SBP) over 99.2 ± 19.0 mmHg (diastolic BP; DBP). At the time of on/off testing BP was reduced to 148.8 ± 26.5 mmHg (SBP; p=0.01) over 87.8 ± 20.3 mmHg (DBP; p=0.09).

On deactivation of the device BP increased by 11.3 ± 15.6 mmHg (systolic BP; p=0.03) and 6.3 ± 11.8 mmHg (diastolic BP; p=0.09) and decreased after reactivation by 15.3 ± 18.0 mmHg (SBP; p=0.01) and 8.1 ± 10.8 mmHg (DBP; p=0.03). There was no correlation between duration of chronic BAT and systolic or diastolic on/off response (all p>0.1).

Conclusions: After 13.6 months of follow-up, unilateral baroreceptor activation therapy (BAT) reduces BP consistently in patients with resistant HTN. The acute on/off response to BAT is the same in patients after long-term treatment as in those with recent device activation. Thus, no evidence of tolerance over time to chronic BAT can be found, indicating that this therapy is fully effective in the long-term treatment of patients with resistant HTN.
Cerebral sinus thrombosis and oral contraceptives
Authors: J. P Vandenbroucke
Journal: BMJ (1998)

Clinical review p 520

In short succession two recently published papers have shown not only a very high relative risk of cerebral sinus thrombosis in users of oral contraceptives but an even stronger effect of contraceptives among women who carry hereditary prothrombotic conditions. 1 2 This raises several questions: Why this sudden wave of publications? Why the very high relative risks? What are the lessons for clinical practice and prevention?

The field of investigation into oral contraceptive use and the occurrence of venous thrombosis has been undergoing a rapid paradigm shift over the past couple of years. That oral contraceptives may cause venous thrombosis has been known since the 1960s, but ever since there have been controversies about the size of the risk, the role of bias in observational research, the role of hormonal dosage, the type of hormones implicated, and—particularly—the glaring absence of any biochemical explanation. Some have even doubted the reality of the association. The discovery of first the factor V Leiden mutation and then the factor II mutation has changed the picture.

These prothrombotic mutations strongly enhance the risk of oral contraceptives causing venous thrombosis, which, firstly, proves …
Abstract 10221: Evaluating the Effectiveness of Rosuvastatin in Preventing the Progression of Diastolic Dysfunction in Aortic Stenosis: A Substudy of the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin (ASTRONOMER) Study
Authors: Davinder S Jassal, Kapil M Bhagirath, Erin Karlstedt, Jean G Dumesnil, Koon K Teo, James W Tam, Kwan Chan
Journal: Circulation (2010)
Abstract 9559: The Role of Myopalladin in the Interactions of ANKRD1/CARP with the Co-Activator p53 in Hypertrophic Cardiomyopathy
Authors: Christopher H Cheng, Jeffrey A Towbin, Enkhsaikhan Purevjav
Journal: Circulation (2011)

Background: Myopalladin (MYPN), a member of the Z-disc that interacts with other Z-disc proteins, including the cardiac ankyrin repeat protein ANKRD1 (CARP). Mutations in MYPN and CARP genes cause human dilated (DCM) and hypertrophic cardiomyopathies (HCM). Both MYPN and CARP have dual distributions in the cytoplasm and nucleus. In the nucleus, CARP is a transcriptional co-activator of p53, repressing expression of the cardiac proteins in an in vitro system. A MYPN-dependent cytoplasmic anchoring for CARP is described although the molecular basis of the MYPN modulation of CARP gene transcription is unclear. Previously, our laboratory identified a novel MYPN variant (MYPN Y20C ) in DCM and HCM patients. A transgenic MYPN Y20C cardiac-restricted overexpression mouse model recapitulates the HCM phenotype.. Methods and Results: In vitro and in vivo studies demonstrated that the MYPN Y20C mutation resulted in perinuclear localization in myoblasts while CARP retained its cytoplasmic/nuclear dual distribution; as did wild-type MYPN. Co-immunoprecipitation revealed decreased association between CARP and MYPN Y20C suggesting a dissociation of the cellular distributions of CARP and MYPN Y20C . In transgenic MYPN Y20C hearts, perinuclear MYPN Y20C had increased association with p53, a co-activator for negative gene regulation of CARP. Nuclear localization of p53 is a critical element in the activation of its transcription. Its sequestration in the cytoplasm renders the protein non-functional. This resulted in a loss-of-function of CARP gene transcription as demonstrated by increased expression of the CARP-specific sarcomeric protein myosin heavy chain (MHC), and atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP) in vivo . CARP was serine phosphorylated and coexpression with MYPN led to suppression of CARP phosphorylation. Conclusion: Our study demonstrates a novel role for myopalladin in the development of HCM. The perinuclear/cytoplasmic sequestration of p53 by MYPN Y20C resulted in the inactivation of p53, which leads to loss-of-function of CARP gene regulation. Our data also suggests that myopalladin plays a pivotal role in relaying cardiac Z-disc signaling to those proteins involved in CARP phosphorylation/activation.
Metformin Affects the Proliferation Cell Nuclear Antigen (PCNA) and p21 Protein Interaction Resulting in Direct Anti-Tumor Activity and Enhances the Cytotoxic/Biological Effects of Chemotherapy Agents or Rituximab in Lymphoma in Vitro and in Vivo Pre-Clinical Models
Authors: Juan J Gu, Vivek Yanamadala, Anil Singh, Cory Mavis, Myron S. Czuczman, Francisco Hernandez
Journal: Blood (2014)
Do we need to further educate healthcare professionals with smoking cessation referral
Authors: Sheila Farnan, Emily Morris, Gurinder Tack, Dilip Nazareth, Duncan Fullerton
Journal: European Respiratory Journal (2014)

Background   NICE (UK) recommends 1  that all health care professionals take the opportunity to refer smokers to a smoking cessation service (SCS) and this is a UK health priority.  Our district general hospital has a smoking cessation in-reach service. The objectives of this study were to evaluate referral rates to this service among patients admitted to hospital via the Acute Medical Unit (AMU) with a view to improving the referral rates.   Method   We undertook a 2-week prospective review during winter of all admissions via the MAU to the respiratory ward, of smoking referral patterns.   Results   73 patient records were reviewed. Mean age 71 (SD 13) years; 52% male, 40% current smokers. Of these only 36% received documented smoking cessation advice from a health care professional on admission and 41% of these smokers were referred to SCS services, of which 30% received a review within 24 hours and 86% within 72 hours; following this 24% continued to smoke whilst an in-patient.   Conclusion   Ideally a SCS review should be within 24 hrs of admission. We are working with our MAU and SCS teams to enhance training and increase the referral rates to SCS in line with NICE guidance 1 , by implementing a regular education programme for all healthcare professionals.   Reference:   1. NICE- www.guidance.nice.org.uk/CG101/Guidance/pdf/English.
Abstract 288: Positive Correlation of Intracoronary C-Reactive Protein With Platelet-Monocyte Complexes and Serum Amyloid A Protein Suggests Local Interrelationship Between Platelet Activation and Inflammation in the Acute Coronary Syndrome Patients.
Authors: B Majumder, M Lowdell, R Gallimore, H Lachman, J G Coghlan, M F Shiu, R D Rakhit
Journal: Circulation (2010)

Introduction: — Formation of platelet monocyte complexes (PMCs) may be a link between platelet activation and inflammation in the pathogenesis of acute coronary syndrome (ACS). It is not clear whet...
Abstract 2404: ECG Estimate Of Ischemic Acuteness and Time from Pain Onset for Predicting Myocardial Salvage in Patients Undergoing Primary Percutaneous Coronary Intervention
Authors: Henrik Engblom, Bo Heden, Erik Hedstrom, Galen Wagner, Håkan Arheden
Journal: Circulation (2007)

Background: The potential for salvage of jeopardized myocardium during coronary occlusion decreases as the duration of persistent ischemia is prolonged. Thus, it is important to be able to assess the acuteness of ischemia as a patient presents with signs of acute coronary syndrome. The aim of this study was to compare ECG estimate of ischemic acuteness and time from pain onset for predicting myocardial salvage in patients with first-time myocardial infarction (MI). Methods: Thirteen patients with acutely revascularized first-time MI were studied. All patients had 99mTc tetrofosmin injected and an ECG recorded prior to the PCI. TIMI III flow was obtained in all patients. Single photon emission computed tomography (SPECT) was undertaken within 3 hours of the PCI to assess the myocardium at risk (MaR). Delayed contrast-enhanced magnetic resonance imaging (DE-MRI) was performed 1 week after admission for assessment of infarct size (IS) and infarct transmurality (IT). A salvage index was calculated as (MaR-IS)/MaR. The acuteness of ischemia was estimated both from patient history and from the Anderson-Wilkins (AW) acuteness score of the pre-PCI ECG. Results: The figure shows the relationship between time of symptom onset and salvage index (A) and IT (C) as well as the relationship between AW acuteness score and salvage index (B) and IT (D). The time of symptom onset did not correlate with salvage index or IT. The AW acuteness score, however, showed a significant relationship with both salvage index and IT. Conclusions: The initial ECG changes are superior to time from symptom onset to PCI for predicting myocardial salvage and IT in patients undergoing PCI of first-time MI.
Abstract 11: Is Therapeutic Hypothermia After Cardiac Arrest Harmful For Diabetic Patients?
Authors: Tom Ploj, Urh Groselj, Marko Kavcic, Marko Noc
Journal: Circulation (2006)

Mild induced hypothermia (MIH) improves survival and neurological outcome in comatose patients after resuscitated cardiac arrest due to ventricular fibrillation. Diabetes correlates with poor progn...
Hospital Patients who Wear Tinted Spectacles - Physical Sign of Psychoneurosis: A Controlled Study
Authors: R J W M Howard, R M Valori
Journal: Journal of the Royal Society of Medicine (1989)

The wearing of tinted spectacles by patients is often said to be a marker of psychopathology but without supportive evidence. To investigate the validity of this observation the personalities of 20 medical hospital patients who wore tinted spectacles were compared, by means of a self-report inventory, with those of 20 controls who were age, sex, and diagnosis matched. There was a significant increase in the level of psychopathology in the tinted spectacle group, both in terms of an index of global psychological distress; the General Severity Index, and nine primary symptom dimensions measured by the inventory.
Abstract 16959: Cardiomyocyte-Restricted Inhibition of p53 Activity Exacerbates Late Stage Doxorubicin Cardiotoxicity in a Juvenile Mouse Model
Authors: Wuqiang Zhu, Sean Reuter, Wenjun Zhang, Ronald M Payne, Lei Wei, Randall Caldwell, Weinian Shou, Loren Field
Journal: Circulation (2010)

Introduction: Doxorubicin (DOX) is an effective anti-cancer therapeutic which induces transient cardiotoxicy during acute drug delivery. Cardiotoxicity re-occurs in some patients years after drug t...
Abstract 11787: The Influence of Depression on Treatment Adherence Among Older Workers with Coronary Heart Disease (CHD)
Authors: Victoria Dickson, Alexandra Howe, Joshua Deal, Margaret McCarthy
Journal: Circulation (2011)

Older workers with CHD must meet the challenges of today's work processes including increased stress and intense production demands while managing complex treatment regimens. Depression is very common in individuals with CHD and may further impede older workers ability to adhere to medication, diet, exercise and symptom monitoring recommendations; especially when jobs are stressful. The purpose of this study was to explore the relationship of depression to treatment adherence among older workers with CHD. Methods: In this cross-sectional study; 121 older workers (>age 50) with CHD (mean age 63.3 years ± 7.1) completed standardized instruments about adherence (Medical Outcomes Study Specific Adherence Survey α= .74), depression (PHQ-9 α = .84), job characteristics (Job Content Questionnaire α= .71) and physical functioning (Duke Activity Status Index α= .79). Correlational and regression methods were used in the analysis. Results: The sample was 56.8% female, 34.4% African American, 79.6% were employed (59...
Abstract 16488: Overexpression of the Human Form of the Novel Extracellular Matrix Protein Podocan Inhibits Migration and Proliferation of Human Vascular Smooth Muscle Cells via Down-Regulation of the Wnt-Pathway
Authors: Randolph Hutter, Chiara Giannarelli, Li Huang, Juan Badimon, Paul Klotman
Journal: Circulation (2011)

Background: Vascular smooth muscle cell (VSMC) biology modulates the clinical course of vascular disease. Podocan is a novel member of the small leucin rich repeat protein (SLRP) family. We have re...
Abstract 11779: Tie2-Expressing Macrophages Induced by PHD2 Haplodeficiency Prevents Ischemic Damage After Limb Ischemia and Myocardial Infarction by Inducing Collateral Artery Growth
Authors: Yukiji Takeda, Sandra Costa, Estelle Delamarre, Carmen Roncal, Rodrigo Leite De Oliveira, Mario Leonardo, Veronica Finisguerra, Mathias Wenes, Sofie Deschoemaeker, Jens Serneels, Zhenwu Zhuang, Michael Simons, Yoshihiko Saito, Michele De Palma, Massimiliano Mazzone
Journal: Circulation (2011)

We already demonstrated that heterozygous deficiency of PHD2 oxygen sensor promotes vessel stabilization and maturation, thus increasing oxygen supply. Thus, we investigated the role of PHD2 in ischemia. Despite femoral artery ligation, PHD2+/- mice displayed nearly normal perfusion of the lower limb that prevented the ischemic damage of the muscle and preserved the running performance. The same was true in a mouse model of myocardial infarction. We found that, at baseline, collateral arteries in PHD2+/- mice were more functional, larger, and surrounded by a thicker media layer, altogether allowing the blood flow to bypass the occlusion point. Quantitative PCR analysis of PHD2+/- peritoneal macrophage showed the mRNA level of Tie2 was significantly up-regulated together with other arteriogenic M2 genes including Arginase1, CXCR4, CCR2, HGF, PDGF-B, FIZZ, Neuropilin1, and SDF1 when compared to WT. Smooth muscle cells (SMCs) were chemoattracted 10 times more potently towards PHD2+/- than WT macrophages in v...
CLINICAL-PATHOLOGICAL CONFERENCE
Authors: Wallace M. Yater, Charles F. Branch
Journal: Annals of Internal Medicine (1942)

Article1 July 1942CLINICAL-PATHOLOGICAL CONFERENCEWALLACE M. YATER, M.D., F.A.C.P., CHARLES F. BRANCH, M.D.WALLACE M. YATER, M.D., F.A.C.P.Search for more papers by this author, CHARLES F. BRANCH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-1-5 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Yater: After having read the history of the case we are to discuss this morning, I am convinced that there are just as hard medical nuts to crack in Boston as there are in Washington and elsewhere. I approach a discussion of this case with fear and trepidation, and hope it will not turn out to be a Dunkirk for me.May I suggest that we refresh our minds concerning this rather mystifying case by reading it over again together from beginning to end.CLINICAL HISTORYThe patient was a 35 year old man, by occupation a wood-worker. When... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *One of the Clinical-Pathological Conferences given at the Annual Meeting of the College in Boston on April 22, 1941, under the direction of Dr. Reginald Fitz. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1942Volume 17, Issue 1Page: 5-11KeywordsFear ePublished: 1 December 2008 Issue Published: 1 July 1942 PDF downloadLoading ...