tbuckley/cabot-search huggingface dataset:
Use of an ex vivo multiplexed signal pathway inhibitor treatment to reveal sensitivity of myeloma and nonmyeloma bone marrow cell populations.
Authors: L. A. Liotta, A. Romano, A. VanMeter, G. J. Orloff, A. I. Spira, D. Patel, D. Dunning, L. Steger, E. Petricoin, V. A. Espina
Journal: Journal of Clinical Oncology (2010)

e18532 Background: Myeloma cells are admixed with normal cells in the bone microenvironment. A great need exists to understand the differential effect of treatment on myeloma as well as the non-myeloma cells. We designed a study to rapidly screen ex vivo treatment combinations to predict treatment efficacy. Methods: A panel of signal pathway inhibitor treatments was applied to fresh bone marrow aspirate samples from patients undergoing standard of care hematological work up for multiple myeloma. Bone marrow aspirates (n=22 to date), not required for diagnosis, were immediately subdivided and treated ex vivo with a panel of molecular targeted inhibitors, including combinations thereof, that target a wide range of cellular pathways (autophagy, proteosome, angiogenesis, protein degradation, proliferation/survival, insulin response, and translation). Up to 48 different treatment conditions could be studied for an aspirate volume of 5mL. After 8 hours incubation the samples were placed in a preservative that suppresses fluctuations in kinase pathway proteins. CD138 positive cells (plasma cells) were separated from CD138 negative cells via immunomagnetic sorting. Reverse phase protein microarrays were used to quantitatively map up to 75 cell signaling pathway endpoints in both cell populations. Results: Accrual has included untreated patients with MGUS, smoldering myeloma, treatment naïve, or advanced stage pre-treated myeloma. Individual samples and disease stages differed widely at the level of cellular signaling in response to ex vivo treatment and combination of drug treatments. In some samples specific kinase inhibitors were found to suppress their expected targets to a higher degree in CD138 positive vs CD138 negative cells. In other samples the same inhibitor was associated with compensatory activation of down stream pathways. However, in many cases the specific inhibitor had a much greater effect on the non-CD138 positive cells compared to the CD138 positive cells. Conclusions: Choices for individualized and/or combination therapy should take into consideration the differential effect of therapy on the non-myeloma cells compared to the myeloma cells. No significant financial relationships to disclose.
Pregnancy-related affective episodes among women with recurrent depression
Authors: E Frank, D J Kupfer, M Jacob, S J Blumenthal, D B Jarrett
Journal: American Journal of Psychiatry (1987)

The authors examined 52 women with recurrent depression to determine the differences between women with and without histories of pregnancy-related affective episodes. The women with histories of such episodes (N = 24) had been significantly younger at illness onset, were more severely depressed at baseline, and tended to show less emotional stability. The EEG-recorded sleep of the women with pregnancy-related affective episodes was distinguished by longer REM sleep time and more REM activity, differences accounted for almost entirely by the women with histories of only postpartum episodes.
Abstract 14784: Long-Term Follow-up After Myocardial Contrast Echocardiography-Guided Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy
Authors: Amir-Ali Fassa, Thierry Lefevre, Marie-Claude Morice, Jean-Francois Piechaud, Marie-Christine Malergue, Yves Louvard, Philippe Garot, Bertrand Cormier
Journal: Circulation (2011)

Aim: Report the immediate and long-term results of alcohol septal ablation (ASA) guided by myocardial contrast echocardiography (MCE) for treatment of symptomatic hypertrophic obstructive cardiomyo...
A Phase I Dose Finding Study of Panobinostat in Children with Hematologic Malignancies: Initial Report of TACL Study T2009-012 in Children with Acute Leukemia
Authors: John M Goldberg, Julia Glade-Bender, Maria Luisa Sulis, Rebecca A Gardner, Jessica A. Pollard, Victor Aquino, Naomi J. Winick, Bruce C. Bostrom, Cecilia Fu, Raymond J. Hutchinson, Thomas J. Manley, Rajen Mody, Javier Oesterheld, Blythe Thomson, Julie R Park, Jeannette Cassar, Elena Eckroth, Richard Sposto, Yoav H Messinger, Nobuko HiJiya, Paul S Gaynon, Julio C. Barredo
Journal: Blood (2014)
Abstract 19356: Mortality Trends in Hypertensive Patients Indicate Optimal Blood Pressure Targets
Authors: Ross D Fletcher, Richard Amdur, Ronald E Jones, Charles Faselis, Vasilios Papademetriou
Journal: Circulation (2010)

Introduction: The impact of blood pressure control on health outcomes has been shown in many double blind randomized clinical trials. However an optimal blood pressure level for systolic or diastol...
Abstract 2031: Late Clinical Outcomes of Diabetic Patients Randomized in the Occluded Artery Trial (OAT)
Authors: Christopher B Overgaard, Christopher E Buller, Aldo P Maggioni, Jonathan Leor, Witold Ruzyllo, Jeffrey R Burton, Gilmar Reis, Lea Liu, Gerard Devlin, Waldemar Banasiak, Gervasio A Lamas, Judith S Hochman, Vladimir Dzavik
Journal: Circulation (2008)

In stable, high risk patients with persistent total occlusion of the infarct-related coronary artery, percutaneous coronary intervention (PCI) of this vessel late after myocardial infarction does n...
Use military and private sector to cope with disasters, aid agencies told
Authors: Caroline White
Journal: BMJ (2007)

Aid agencies must make greater use of the military and the private sector if they are to cope with the increasing number of humanitarian disasters, experts have warned.

Speaking at a conference on disaster relief held in London last week, John Mcgrath, programme researcher at Oxfam International, said that climate change and increasing urbanisation were changing the impact, frequency, and pace of disasters.

Disasters had quadrupled since the 1980s, with category 5 floods and storms doubling from 40-50 in the 1970s to 90 in the past five years alone.

“I’m not saying climate change is responsible for everything, but it interacts with other factors, despoiling the environment, so increasing the vulnerability to disaster,” he said.

A particularly worrying trend was the rise in small and medium scale disasters, which brought a death toll of between 6000 and 140 000 and had a devastating impact on people’s livelihoods in poor regions of the world.

“A succession of small shocks has major consequences, pushing people into a spiral of destitution,” he said.

Randolph Kent, director of the Humanitarian Futures programme at King’s College, London, said that non-governmental organisations had to rethink the way in which they respond to disasters.

Networking and closer collaboration were essential to help agencies become “more adaptive and effective,” he suggested.

And sending people out to regions of the world hit by crises would become less and less relevant in increasingly complex situations where the culture was best understood by local people, he said.

Organisations also needed to shift their focus from rural settings to urban conurbations, because 54% of the world’s population lives in cities, most of them on coastal plains, he said.

“The dimensions of future crises will be well beyond the humanitarian sector, and new approaches and techniques will be needed,” he warned.

“You need the private sector. Corporations will be the last ones left,” he said, adding that non-governmental organisations should use the skills and resources of the military.

“They apply lessons learnt after action, they strategise and forward plan, and they invest heavily in research and development,” he said, all of which would be invaluable for developing “disaster preparedness.”

Mike Elmore Meegan, founder and director of the international charity ICROSS, said, “The obvious cock-ups are often caused by not understanding the vast amount of knowledge that’s already out there.”

Changing patterns of mobility and new disease threats were exacerbated by preventable problems, such as low literacy, poor sanitation, and inadequate prevention, he said.

“Disasters are no longer one offs, but a wide spread of ongoing conditions. Before preparedness, we need awareness,” he said.
肥胖基础知识（一）肥胖及其临床表现的评估
Authors: Thang, Han, Naveed, Sattar, Mike, 李玉秀（译）, 王姮（校）
Journal: BMJ (2007)

Twenty eight patients with multiple organ dysfunction syndrome (MODS) underwent continuous venovenous hemofiltration (CVVH)in ICU from June 2003 to June 2008, including 13 cases treated with predilution mode and 15 with postdilution mode. The changes of oxygenate index( PaO2/FiO2 )during CVVH were retrospectively analyzed. The total case fatality rate of this group of patients was 46%(13/28). There was a significant increase in PaO2/FiO2 of 28 cases during the first 48 h of CVVH (P ＜0. 05);the levels of PaO2/FiO2 in predilution group had increased significantly within 48 h during CVVH (P＜0. 05), while those in postdilution group had not significantly changed (P ＞ 0. 05). There was a significant increase in Pa02/FiO2 for the survival patients during the first 48h CVVH( P ＜ 0. 05 ), while no significantly change in the fatal cases(P ＞0. 05 ). In summary, oxygenate function and outcome of patients with MODS can be improved by CVVH, and predilution may be a more effective mode.

Key words: 
Multiple organ failure ;  Hemofiltration ;
Medical student suicide, 1989-1994
Authors: L R Hays, T Cheever, P Patel
Journal: American Journal of Psychiatry (1996)

Studies examining suicide rates for medical students have yielded conflicting data. This article addresses medical student suicide from August 1989 through May 1994.Telephone interviews were conducted with a representative from each U.S. medical school, generally the dean of student affairs. If a suicide had occurred, information regarding demographic characteristics, psychiatric or substance abuse history, means of suicide, month, and presence of a suicide note was obtained.Responses were obtained from 101 (80%) of the 126 U.S. medical schools. Responding schools reported 15 suicides by medical students from August 1989 through May 1994. Fourteen were by men. Six suicides were committed during the third year of medical school, and four occurred during the fourth year. Six students left notes, and nine of 13 had psychiatric histories.The results demonstrate a lower suicide rate than that found in previous studies and emphasize the need for standardized reporting methods.
Fortnightly review: Management of patients with sickle cell disease
Authors: S. C Davies, L. Oni
Journal: BMJ (1997)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Fortnightly review: Management of patients with sickle cell disease Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Abstract 11221: Safety and Efficacy of Exercise Training After Coronary Stenting in Patients with Stable Coronary Artery Disease
Authors: Yoshimitsu Soga, Hiroyoshi Yokoi, Kenji Ando, Shinichi Shirai, Koyu Sakai, Katsuhiro Kondo, Masashi Iwabuchi, Masakiyo Nobuyoshi
Journal: Circulation (2011)
Abstract 1580: Prediction of In-Hospital Mortality in Ischemic Stroke Using Data From Get With the Guidelines Stroke
Authors: Eric E Smith, Mathew J Reeves, Adrian F Hernandez, Jeffrey L Saver, Wenqin Pan, David Dai, DaiWai M Olson, Gregg C Fonarow, Lee H Schwamm
Journal: Circulation (2009)

Introduction: There is increasing interest in mortality as a measure of quality of care in stroke. We used Get With the Guidelines-Stroke program data to derive and validate prediction models for a patient’s risk of in-hospital ischemic stroke mortality. Methods: Between 10/2001–12/2007 there were 1,036 hospitals that contributed complete data on 274,988 ischemic stroke patients. The sample was randomly divided into a derivation (60%) and validation (40%) dataset. Logistic regression models were used to determine characteristics that independently predict patient mortality and to assign point scores for prediction. To determine the effect of the NIH stroke scale score (NIHSS) on model discrimination, we also separately derived and validated a model in the 109,187 patients with NIHSS recorded (39.7%). Results: In-hospital mortality was 5.51% overall and 5.19% in the subset where NIHSS was recorded. Points were assigned for the following predictors in the overall model: age (0 –28 points), method of arrival...
Abstract 3507: Optimal Medical Therapy With or Without Percutaneous Coronary Intervention for Stable Coronary Artery Disease is Effective in Patients with Chronic Kidney Disease
Authors: Steven P Sedlis, Claudine T Jurkovitz, Pamela M Hartigan, Jeffrey D Lorin, Marcin Dada, David J Maron, Koon K Teo, Robert A O’Rourke, William E Boden
Journal: Circulation (2007)

Background : Chronic kidney disease (CKD) is a risk factor for poor outcomes in patients with CAD. Optimal management of such patients is uncertain. CKD patients (especially those with diabetes) are at risk for contrast nephropathy potentially limiting the benefits of percutaneous coronary intervention (PCI). Methods: To evaluate the impact of adding PCI to optimal medical therapy (OMT) in CKD patients with stable CAD we analyzed outcomes stratifying by renal function in the COURAGE trial. We used the abbreviated Modification of Diet in Renal Disease equation to estimate glomerular filtration rate (GFR). Results: A total of 2287 patients were enrolled in COURAGE. Of those, 30% (n=536) had CKD defined as GFR &lt;60mL/min/1.73m 2 . CKD was present in 26% of OMT patients and 21% of OMT +PCI patients. The CKD group was older (66 ±10 versus 61 ± 9.6years P&lt;0.001) had more females (24% versus 12 % p&lt;0.001) more hypertension (71% versus 66% p &lt;0.03) and higher systolic blood pressure (135 ±21 versus 131 ± 19mm/Hg p =&lt;0.001). There was a trend to more diabetes (37% versus 34% p &lt;0.22) and 3 vessel CAD (33% versus 30% p &lt;0.09). ACEI or ARB use was 76% in CKD patients. By 36 months there was similar and intensive risk factor control in patients with and without CKD (systolic blood pressure 125 ± 17 versus 125 ± 17mmHg, LDL 79 ± 24 versus 78 ± 26mg/dL respectively p = NS). The primary composite end-point of COURAGE (death or MI) did not differ by treatment in patients with or without CKD. Rates of death, MI, CHF and angina-free survival at 36 months stratified by treatment status in patients with GFR&gt;60 versus patients with GFR &gt; 60 are shown in the table . Conclusion: Patients with CKD and chronic stable angina when treated with OMT to aggressive blood pressure and lipid goals have marked and sustained improvement in angina similar to patients without CKD. Furthermore, patients with CKD can safely undergo PCI for improved angina control without excess death, MI or CHF when compared to patients treated by OMT alone.
Abstract P152: Obesity Susceptibility Loci and Longitudinal BMI from Adolescence to Young Adulthood in an Ethnically Diverse Cohort
Authors: Mariaelisa Graff, Kari E North, Andrea S Richardson, Kristin L Young, Karen L Mohlke, Leslie A Lange, Ethan M Lange, Kathleen M Harris, Penny Gordon-Larsen
Journal: Circulation (2013)

Genome-wide association (GWA) studies have identi[[Unable to Display Character: &amp;#64257;]]ed nearly 50 common variants for obesity, many of which influence body mass index (BMI), a common proxy for obesity assessed in large epidemiological studies. The associations of these variants with change in BMI across the life course are not well understood, but are of particular interest during the transition from adolescence to young adulthood, a high risk period for weight gain. The current study assessed the association of 41 established obesity SNPs with change in BMI during the period between adolescence and young adulthood in an ethnically diverse, nationally representative cohort, the National Longitudinal Study of Adolescent Health, followed for 13 years. Race/ethnicity-stratified linear mixed models accounted for sampling design, family relatedness, and repeated measures of BMI. Models included a SNP-by-year interaction term and adjusted for sex, age at baseline, current smoking, and geographic region. Analyses included 6383 European American (EA), 2252 African American (AA) and 1700 Hispanic American (HA) participants with measurements from 1996 (ages 12-21 y) to 2008 (ages 24-34 y), with an average of 2.6 observations per individual. For analyses in AA we excluded SNPs (n=14) that failed to capture signal of functional variant in a recent African American population genome-wide association study (Monda et al 2012). Average BMI gain over the 13-year period was 4.9 (SD=5.0) kg/m 2 , with higher increases in AA 5.8 (SD=5.7) kg/m 2 and HA 5.5 (SD=5.6) kg/m 2 . Model results for the 41 SNPs in EA and HA and 27 SNPs in AA suggest that SNP by year interactions show nominal significance (p&lt;0.05) for 12 SNPs in EA, 2 SNPs in HA and 1 SNP in AA. After correction for multiple testing (n=41 tests, p&lt;0.0012), 1 SNP remained significant for EA (rs2287019, near QPCTL ) and none in AA or HA. Each effect allele for rs2287019 contributed an increase of 0.030(SE=0.009) kg/m 2 per year to BMI in EA. These findings suggest that the locus near QPCTL and possibly other obesity loci play a role in the trajectory of BMI across the period from adolescence to young adulthood, a period with high risk for subsequent adult obesity. These findings may help inform the biological processes that influence weight gain at this vulnerable period of the life cycle and may provide information that is useful for the design of effective interventions to prevent weight gain.
Abstract 2235: Prognostic Value of 64 Slices Computed Tomography Coronary Angiography in Patients with Suspected Coronary Artery Disease
Authors: Fabiola B Sozzi, Filippo Civaia, Laura Iacuzio, Stephan Russek, Philipe Rossi, Francois Bourlon, Jean Marco, Gian Battista Danzi, Vincent Dor
Journal: Circulation (2008)

To assess the value of 64-slice computed tomography (CT) coronary angiography for the risk stratification in patients with suspected coronary artery disease (CAD). The prognostic value of 64-slice CT is still unknown. A total of 205 patients (129 men [63%], age 61±10 years) who were referred for further cardiac evaluation due to suspicion of CAD underwent 64-slice CT to evaluate the presence and severity of CAD. It was determined weather the lesion was obstructive or not using a threshold of 50% luminal narrowing. Plaques were classified in calcificed, soft and mixed based on type. End-point during follow-up was hard cardiac events (non-fatal myocardial infarction, unstable angina requiring hospitalization, myocardial revascularization). Coronary plaques were detected in 150 (73%) patients. During a mean follow-up period of 30 months, 83 events occurred in 44 patients. Event-free survival curves in patients with obstructive and non-obstructive lesions respectively and in patients with normal lumen are presented in figure . In patients with normal coronary arteries, the 30-month event rate was 0% versus 46% in patients with significant obstructions (≥50% luminal narrowing) (p &lt;0.001), and 9% in patients with non-significant lesions (&lt;50% luminal narrowing). In multivariate analysis, significant predictors of cardiac events were age, hypercholesterolemia, presence of CAD, obstructive CAD, number of segments with obstructive plaques and obstructive soft plaques. 64-slice CT coronary angiography provides independent prognostic informations over baseline clinical risk factors in patients with suspected CAD.
Abstract 9236: Receptor Tyrosine Kinase Signaling Causes Cardiac Hypertrophy in Adult Drosophila
Authors: Lin Yu, Joseph P Daniels, Matthew J Wolf
Journal: Circulation (2011)

Abnormalities in receptor tyrosine kinase (RTK) signaling are associated with dilated cardiomyopathies and cardiac hypertrophy in humans and mouse models. We have developed strategies based on frui...
Abstract 2425: Absence of Auto-Antibodies against Cardiac Troponin I Predicts Improvement of Left Ventricular Function after Acute Myocardial Infarction
Authors: Florian Leuschner, Jin Li, Stefan Göser, Lars Reinhardt, Renate Öttl, Peter Bride, Jörg Zehelein, Gabriele Pfitzer, Andrew Remppis, Evangelos Giannitsis, Hugo A Katus, Ziya Kaya
Journal: Circulation (2008)

Application of antibodies against cardiac troponin I (cTnI-Ab) can induce dilation and dysfunction of the heart in mice. Recently, we demonstrated that immunization with cTnI induces inflammation and fibrosis in myocardium of mice. Others have shown that autoanti-bodies to cTnI are present in patients with acute coronary syndrome. But little is known about the clinical relevance of detected cTnI-Ab. First, anti-cTnI and anti-cTnT antibody titers were measured in sera from 272 patients with dilated- (DCM) and 185 with ischemic- (ICM) cardiomyopathy. Secondly, 108 patients with acute myocardial infarction (AMI) were included for a follow-up study. Heart characteristics were determined by magnetic resonance imaging 4 days and 6 –9 months after AMI. Altogether, in 7,0% of patients with DCM and in 9,2% with ICM an anti-cTnI IgG antibody titer ≥1:160 was measured. In contrast, only in 1,7% of patients with DCM and in 0,5% with ICM an anti-cTnT IgG antibody titer ≥1:160 was detected. Ten out of 108 patients included in the follow-up study were tested positive for cTnI-Ab with IgG Ab titers ≥1:160. TnI-Ab negative patients showed a significant increase in LVEF and stroke volume 6 –9 months after AMI. In contrast, there was no significant increase in LVEF and stroke volume in TnI-Ab positive patients. We demonstrate for the first time that the prevalence of cTnI-Abs in patients with AMI has an impact on the improvement of the LVEF over a study period of 6 –9 months.
Abstract P85: Prehospital Transport of Patients With Acute Heart Failure: Prognostic Significance of Delay in Hospital Arrival
Authors: Masashi Takahashi, Shun Kohsaka, Hiroaki Miyata, Tetsuo Sakai, Yuichiro Maekawa, Atsutoshi Takagi, Toshihisa Anzai, Kazumasa Harada, Masaru Suzuki, Takamichi Miyamoto, Shingo Hori, Ken Nagao, Naoki Satoh, Tsutomu Yoshikawa, Morimasa Takayama
Journal: Circulation (2009)

Background - The objective of this registry-based study was to examine the use of emergency medical service in metropolitan Tokyo among acute heart failure (AHF) patients. Recently, due to shortage...
Abstract 1914: BMS753951: A Novel Low Molecular Weight Magnetic Resonance Contrast Agent Selective For Arterial Wall Imaging
Authors: David Onthank, Padmaja Yalamanchili, Richard Cesati, Joel Lazewatsky, Michael Azure, Megan Hayes, Mania Kavosi, Kelly Spencer, Debby Sousa, Eric Wexler, Melanie Lamoy, Thomas Harris, Carol Hu, Reinaldo Jones, Greg Dwyer, David Casebier, Simon Robinson
Journal: Circulation (2007)

Non-invasive imaging procedures to identify atherosclerotic lesions in peripheral or coronary vessels are currently limited. A discovery program identified a low molecular weight gadolinium chelate...
Abstract 2447: Isoproterenol, but Not Vagomimetic Agents or Burst Pacing, Initiates Human Atrial Fibrillation by Steepening Action Potential Duration Restitution
Authors: David E Krummen, Sanjiv M Narayan
Journal: Circulation (2009)

Background: Isoproterenol, adenosine, and rapid pacing are known to induce atrial fibrillation (AF), yet via unclear mechanisms. We set out to determine if they steepen left atrial (LA) action pote...