tbuckley/cabot-search huggingface dataset:
Campaigners urge India to resist pressure to change patent laws
Authors: Z. Kmietowicz
Journal: BMJ (2015)

The international medical humanitarian organisation Medecins Sans Frontieres (MSF) has urged the Indian prime minister, Narendra Modi, to resist pressure to change the country’s patent laws so it can retain its status as the “pharmacy of the developing world.”

In a campaign launched on 11 June MSF said that pressure was intensifying from the European Union, Japan, Switzerland, and the United States for India to make it harder for companies to produce cheap, generic drugs on which millions of people around the world rely.

The campaign coincides with the eighth round of negotiations for the Regional Comprehensive Economic Partnership trade agreement taking place 8-13 June in Kyoto, Japan, at which …
The Histogenesis of Thyroid Cancer.
Authors: Nicoale Simionescu
Journal: Annals of Internal Medicine (1971)

wars to create the present efflorescence.The aulthor, Dr. Shands, is a distinguished leader in the development of the more scientific second phase of orthopedics and there- fore an ideal interpreter of the transition from the period of the "strap and buckle" pioneers to the present, main- taining that essential historical continuity expressed in his own quotation: "The heritage of the past is the seed that brings forth the harvest of the future."In twelve carefully documented biographies Dr. Slhands presents to us the work of the early orthopedic sturgeons of America.What a galaxy of ingenious and dedicated men they were, whose names are household words in imiedicine althouigh unfortunately their personalities and the nature of the contributions are not.
Valsalva Retinopathy
Authors: Netan Choudhry, Rajesh C Rao
Journal: New England Journal of Medicine (2014)

A 25-year-old woman at 11 weeks of gestation presented with sudden, painless, central “dark” vision after an episode of forceful vomiting. Funduscopy revealed sedimented preretinal hemorrhage that was enclosed by a dome-shaped preretinal membrane.
A memorable patient: A death on the Rock
Authors: G B Forbes
Journal: BMJ (1998)

This is a tale of serendipity tinged with sadness and it spans some 55 years. Edwin Hutt, a 24 year old stoker in the Royal Navy, sustained fractures of both legs and other injuries when his ship was torpedoed in the Mediterranean in 1942. He was taken to the military hospital in Gibraltar where I was serving in the Royal Army Medical Corps as a graded pathologist.

After a prolonged illness complicated by lung abscesses and septicaemia he died three months after admission. Bacterium (now Fusobacterium) necrophorum was isolated repeatedly on anaerobic culture of …
An American Text-Book of Pathology, for the Use of Students and Practitioners of Medicine and Surgery
Authors: Ludvig Hekton, David Riesman
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fortnightly review: Cognitive behaviour therapy clinical applications
Authors: S. J Enright
Journal: BMJ (1997)

Although there are many variants of cognitive behaviour therapy, these are unified by the proposition that psychological problems arise as a direct consequence of faulty patterns of thinking and behaviour.Patients tend to misinterpret situations or symptoms in ways that undermine their coping.Their abnormal behavioural patterns exacerbate and consolidate these problems.The critical factor lies in how patients assess specific situations or problems-as summarised by Epictetus, a first century Greek philosopher: "Men are disturbed not by things, but the views they take of them." 1 MethodsThis review of cognitive behaviour therapy is based on a literature search of all papers, books, and chapters related to its application in mental health and general medicine.In the search I used the following key words-cognitive, behaviour, behavioural, theory, therapy, treatment-and searched the following databases on the Embase CD ROM from September 1985
Abstract 8596: Reproducibilty of the Syntax Score (Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) in a Real World Setting: Implications for the Choice of Contemporary Revascularisation Strategy
Authors: Henry O Savage, Robert T Gerber, Kare Tang, Bhavesh Sachdev, Graham Cole, Geoffrey Watson, Tiffany Patterson, Ravi Assomoll, Badhusha Noor, Andrew S Sharp, Aamir Ali, Ramzi Khamis, Darryl Francis
Journal: Circulation (2011)

INTRODUCTION: The two year results from the Syntax study indicate that percutaneous coronary intervention (PCI) may be an acceptable alternative to CABG in subjects with a low (&lt;22) and intermediate (23-32) Syntax Score (SS). Patients with high SS (≥33) appear to have worse outcome from PCI. It has been suggested that CABG should remain the treatment in this cohort. The Syntax investigators report good reproducibility for the SS; however, the inter and intra operator variability has not been tested outside the core lab environment. This is pertinent as more cardiac multidisciplinary meetings (MDT) are using the SS to help guide revascularization strategy. METHODS: 20 patients presented at our MDT were randomly selected and 11 cardiologists of differing experience independently scored these angiograms on two separate occasions, after completing the teaching module at www.syntaxscore.com. RESULTS: There was wide variation in SS for each angiogram with 8.4±1.3 min required per SS (Figure). Moreover, variation did not conform over the two sittings to operator experience or to lesion complexity (Mean Difference between scores per operator 9±4). The total mean scores from all operators were taken as a gold standard result with respect to tertile allocation. Operators allocated 50% of patients to a different tertile, with only 2 patients placed by all operators in the same tertile of risk. Additionally, at the second sitting the same operators cast the same angiogram into a different tertile of risk from their original assessment on 46% of occasions. CONCLUSION: Syntax scoring in a real world MDT setting was not reproducible and demonstrated significant intra and inter operator variability between subjects. MDT discussions incorporating this score should be aware of this and weigh the significance of the score accordingly when forming decisions about revascularization strategy.
Les urticaires crises hémoclasiques.
Authors: Édouard Joltrain
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Age limit should be reviewed
Authors: R M Archibald
Journal: BMJ (1996)

least, more than one symptom could be scored and perhaps more attention could be paid to the patients' experience of their illness,' including how they explain their illness and its course, what effect it has, how they feel about it, and what they expect of treatment (this is relatively easily done in an n of 1 trial).The n of 1 trial could indeed be used more in everyday clinical practice with good instruments, generic diaries, and a patient centred approach.
Abstract 16428: Incidence and Survival Trends of Heart Failure Complicating First Myocardial Infarction in Western Australia between 1996 and 2007
Authors: Tiew-Hwa K Teng, Joseph Hung, Judith C Finn, Matthew Knuiman, Simon Stewart, Tom Briffa, Frank Sanfilippo, Steve Ridout, Michael Hobbs
Journal: Circulation (2010)
研究人员优化体外实验方法以减少“首次应用于人体”的药品试验风险
Authors: Susan, Mayor, 梁立智, 王晓燕
Journal: BMJ (2009)

英国研究人员通过调查2006年发生的免疫调节因子TGN1412药品试验失败（导致6名健康的志愿者患上严重疾病）的事故原因，研发出一种体外实验方法，这种方法可能预测出该药在人体实验前的严重副反应。
Abstract 19668: Resource Utilization in the Era of Contemporary Sensitive Cardiac Troponin Assays: Comparisons Among Type 1 Myocardial Infarction, Type 2 Myocardial Infarction, Non-Myocardial Infarction Troponin Increases, and Patients with Negative Troponin
Authors: Yader Sandoval, Stephen W Smith, Karen M Schulz, MaryAnn M Murakami, Fred S Apple
Journal: Circulation (2014)

Introduction:  Increased cardiac troponin (cTn) values (>99th percentile) are frequently encountered in clinical practice and have become a routine challenge for clinicians who must discern between type 1 myocardial infarction (T1MI), type 2 MI (T2MI) and non-MI cTn increases to tailor appropriate therapies and/or interventions. Our purpose was to compare resource utilization and outcomes among patients with T1MI, T2MI and non-MI cTn increases, in contrast to patients with normal cTn.   Methods:  A retrospective cohort of 310 patients with serial, contemporary cTnI (Abbott ARCHITECT, 99th percentile: 30 ng/L) measurements was reviewed. All patients with an increased cTnI underwent event adjudication according to the Third Universal Definition of MI. Resource utilization including the need for cardiology consultations, echocardiography, angiography, and antiplatelet/anticoagulant therapies, along with length of stay and mortality were obtained and compared among patients with T1MI, T2MI, non-MI cTnI increases and non-MI patients with normal cTnI.   Results:  Acute MI occurred in 13.9% (n=43) patients. 4.5% (n =14) had T1MI and 9.4% (n=29) T2MI. Non-MI cTnI increases occurred in 36.1% (n=112). 50.0% (n=155) had normal cTn (   Conclusions:  Patients with T2MI and non-MI cTnI increases often received antiplatelet and/or anticoagulant medications traditionally used for T1MI. Frequent resource utilization and interventions among patients with non-plaque rupture etiologies support the need to develop cost-effective diagnostic algorithms and evidence-based guided management among these patients.
Abstract 2718: Does the Lack of Ventricular Dyssynchrony Prior to Cardiac Resynchronization Therapy Affect Ventricular Remodeling and Long-Term Clinical Outcomes?
Authors: Alan D Waggoner, Lisa de las Fuentes, Mitchell N Faddis, Marye J Gleva, Karen E Spence, Victor G Davila-Roman
Journal: Circulation (2007)

Introduction: Left ventricular (LV) dyssynchrony, determined by tissue Doppler imaging (TDI), has been proposed as a method to select patients with heart failure (HF) with prolonged QRS intervals that are likely to respond to cardiac resynchronization therapy (CRT). It has been reported that the lack of LV dyssynchrony prior to CRT can be associated with less LV reverse remodeling and less clinical improvement after CRT. Methods : 80 patients were evaluated by 2D/pulsed-wave Doppler (PWD) echocardiography and TDI prior to and 4 ± 1 months after CRT. Measurements included LV end-diastolic (EDV), end-systolic (ESV) volume and ejection fraction (LVEF). TDI-derived time intervals of Q to peak systolic (Sm) velocity were measured at 4 mitral annular sites (i.e., lateral, septal, anterior, inferior); maximal difference between sites was defined as presence of LV dyssynchrony. Functional measurements included NYHA class, HF score, and 6 minute walk distance. Clinical events, defined as HF re-hospitalization or cardiac-related death/transplant, were evaluated at median follow-up of 30 months (range 3– 68). Patients were grouped by pre-CRT TDI-derived Q-Sm difference of ≤ or &gt; 65 ms ( Bax et al JACC 2004 ; 44 : 1834 –40 ). Results: Age, gender, HF etiology, QRS duration, and LV lead position were similar between groups. LV volumes decreased and LVEF increased significantly in both groups after CRT (see table ). TDI-determined Q-Sm difference decreased significantly only in the ≤ 65 ms group. Functional measurements improved in both groups. Clinical events at long-term follow-up were similar in the group with Q-Sm ≤ 65 ms. vs. Q-Sm &gt; 65 ms. [n = 13 (33%) vs. n = 11 (28%), respectively]. Conclusions: Despite a lack of significant LV dyssynchrony by TDI measurements prior to CRT, LV volumes decreased, LVEF increased, and functional measurements improved significantly at 4-month follow-up. Furthermore, the lack of LV dyssynchrony did not influence long-term clinical outcomes.
Unusual Cluster In Time and Space Of Dengue-Associated Hemophagocytic Lymphohistiocytosis In Puerto Rico
Authors: Esther M. Ellis, Janice Pérez-Padilla, Liza González, Emmaculate Lebo, Charlotte Baker, Tyler Sharp, Eduardo Ochoa, Hector Díaz-Pinto, Luis A. Clavell, Anabel Puig-Ramos, Erskin Berzares, Camille Lupiañez-Merly, Haydee Garcia, Gritta E. Janka, Harold Margolis, Kay M Tomashek
Journal: Blood (2013)
The Animal as a Converter of Matter and Energy. A Study of the Rôle of Live Stock in Food Production.
Authors: Henry Prentiss Armsby, Charles Robert Moulton
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Active Immunization Against Diphtheria: Its Effect on the Distribution of Antitoxic Immunity and Case and Carrier Infection
Authors: Sheldon F. Dudley, Percival M. May, Joseph A. O'Flynn
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FiRe works – the Finnish Study Group for Antimicrobial Resistance (FiRe)
Authors: A Nissinen, P Huovinen
Journal: Eurosurveillance (2000)

The Finnish Study Group for Antimicrobial Resistance (FiRe), a network founded in 1991, has established a standard routine susceptibility testing method that yields reliable and comparable results for both diagnostic and epidemiological purposes. Results
"Experiments in the Physiology of Human Performance"
Authors: Benjamin Ricci
Journal: British Journal of Sports Medicine (1970)

This practical handbook of experiments in human physiology is comple- mentary to the same author's "Physiological basis of Human Performance" (1969), already reviewed in Brit.Journ.Sports Med.Vol.lV No. 4, but it can well be used in conjunction with other textbooks of physiology.
Prognostic and predictive impact of EGFR and K-ras mutation, and EGFR gene copy number in patients with advanced non-small cell lung cancer (NSCLC) who received first-line cytotoxic chemotherapy
Authors: Y. Tambo, K. Kasahara, T. Sone, H. Kimura, A. Sakai, T. Araya, A. Ueda, M. Fujimura, S. Nakao
Journal: Journal of Clinical Oncology (2009)

8096 Background: Epidermal growth factor receptor (EGFR) mutations, amplification, and K-ras mutations are known as predictive factor of the EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy in patients (pts) with NSCLC. Prognostic influences of those biomarkers remain the matter to be discussed. Methods: Consecutive pts with advanced NSCLC who were examined EGFR genotype and received 1st line cytotoxic chemotherapy were enrolled. EGFR amplification and K-ras mutation were analyzed if sufficient tumor samples were available. Results: 87 pts were enrolled in this study. EGFR mutations or K-ras mutations were found in 26 of 87 (29.9%) or 2 of 65 (3.1%) pts, respectively. As to objective response rate (ORR), no significant differences were observed among pts with EGFR mutations, K-ras mutations, and pts without both mutations. Progression free survival (PFS) in 1st line cytotoxic chemotherapy was 8.4, 1.0, and 3.9 months in pts with EGFR mutations, with K-ras mutations, and pts without both mutations, respectively. PFS was longer in pts with EGFR mutations compared with the pts without both mutations (p=0.0234). We also found the pts with K-ras mutations had shorter PFS compared with pts without both mutations (p=0.0203). Overall survival (OS) was 29.7, 2.3 and 13.4 months in pts with EGFR mutations, with K-ras mutations, and pts without both mutations, respectively. Significant differences were found between pts with EGFR mutation and without both mutations (p=0.0001) and between pts without both mutations and with K-ras mutations (p=0.0001). Pts with EGFR amplification were found in 21 of 78 (26.9%). There were no differences between EGFR amplification positive and negative in terms of ORR, PFS and OS. 87 of 68 (78.2%) pts received EGFR-TKI therapy in the second line or later. As previously reported, both EGFR mutations and amplifications were good predictive marker of ORR, PFS and OS in pts treated with EGFR-TKI. Conclusions: EGFR mutations were good predictive marker and K-ras mutations were poor predictive marker in first line cytotoxic chemotherapy. There is the possibility that EGFR and K-ras mutations have the prognostic impact in advanced NSCLC. [Table: see text]
Patients need a real say in the NHS, not just to be 'muppets', says report.
Authors: Tessa Richards
Journal: BMJ (2001)

Appointing lay members to health decision making bodies does not ensure patients' views are represented, says a new report launched last week by the Kings Fund, an independent health care charity.

Speaking at the launch, one disgruntled lay member of a primary care group said the only thing she was asked to do was buy the wine for the Christmas party.

“Trusts are uncomfortable with lay involvement,” said Maria Duggan, lay member of West Harringay primary care group. “They are unwilling to accept the views of lay “muppets,” as we have been called.

“Doctors also seem reluctant to work on an equal …
Pentachlorophenol poisoning in newborn infants - St. Louis, Missouri
Authors: J. Earl Smith
Journal: MMWR Morbidity and Mortality Weekly Report (1967)

From April to August 1967, nine cases of a clinically distinct illness characterized by fever and profuse sweating occurred in a small nursery for newborns in St. Louis, Missouri. Two of the cases were fatal. Early in the course of the outbreak the disease was felt to be an intoxication, but the nature of the poison and the mode of exposure of the patients remained obscure. Only after the ninth case developed was it discovered that an anti-mildew agent, containing a high concentration of sodium pentachlorophenate (the sodium salt of pentachlorophenol), was being used in the hospital laundry. All of the clinical. epidemiological, and biochemical evidence indicated that this outbreak resulted from pentachlorophenol poisoning. The only identified mode of exposure was skin absorption of sodium pentachlorophenate residues on diapers and other fabrics, resulting from the misuse of the anti-mildew agent in the final laundry rinse.
Emerging Drug Resistance and Vaccination for Typhoid Fever—Reply
Authors: Jonathan M. Zenilman
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal