tbuckley/cabot-search huggingface dataset:
Comment on ‘The role of aspirin versus low-molecular-weight heparin for venous thromboembolism prophylaxis after total knee arthroplasty: a meta-analysis of randomized controlled trials’
Authors: Xiaochen Zhang, Yu Ren, Hua Luo
Journal: International Journal of Surgery (2024)

aDepartment of Psychiatry, Taizhou Second People's Hospital bDepartment of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University cDepartment of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China X.Z. and Y.R. have contributed equally to this work and share first authorship. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, No.150 Ximen Road, Taizhou 317000, Zhejiang, China. Tel.: +86 18732196660. E-mail address: [email protected] (H. Luo). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Efficacy of stem cell therapy in patients with chronic liver disease: an umbrella review of systematic reviews
Authors: Yue Teng, Abhay M Gaidhane, Bijaya Kumar Padhi, Quazi Syed Zahiruddin, Saad Alhumaid, Rakesh Kumar Sharma, Sarvesh Rustagi, Prakasini Satapathy, Divya Sharma, Mithhil Arora, Ali Hazazi, Amani Alturaifi, Mansoor Abdulaziz AlRshoud, Ali A. Zaidan, Fadel A. M. Almosa, Suha A. Alzayer, Razi Al Alqam, Raghad Alhajaji, Ali A. Rabaan
Journal: International Journal of Surgery (2024)

Background: Stem cell therapy offers promising benefits like modulating immune responses, reducing inflammation, and aiding liver regeneration. This umbrella review seeks to compile evidence from systematic reviews to assess the efficacy of stem cell therapy for improving liver function and survival rates in chronic liver disease patients. Methods: We searched electronic databases up to February 15, 2024. The selection process focused on systematic reviews comparing stem cell therapy with standard care or a placebo. The primary outcomes evaluated were changes in liver enzymes, the Model for End-Stage Liver Disease score, and survival rates. Nested Knowledge software was utilized for screening and data extraction. All statistical analyses were performed using R software, version 4.3. Results: Our umbrella review included 28 systematic reviews. The meta-analysis showcased a notable improvement in survival rates with a pooled relative risk of 1.487 [95% confidence interval (CI): 1.281–1.727). In nonrandomized studies, albumin levels exhibited a standardized mean difference (SMD) of 0.786 (95% CI: 0.368–1.204), indicating positive therapeutic effects. For alanine aminotransferase, the meta-analysis revealed a decrease in levels with an SMD of −0.499 (95% CI: −0.834 to −0.164), and for aspartate aminotransferase, an overall SMD of −0.362 (95% CI: −0.659 to −0.066) was observed, suggesting hepatoprotective effects. No significant changes were observed in total bilirubin levels and Model for End-Stage Liver Disease scores in randomized controlled trials. Conclusion: Stem cell therapy exhibits potential as a novel treatment for chronic liver diseases, as it has demonstrated improvements in survival rates and certain liver function markers. More high-quality randomized controlled trials are needed in the future to fully ascertain the efficacy of stem cell therapy in this patient population.
Generative AI intervention clinical trials: a call for pre-registration (Correspondence)
Authors: Haiyang Wu, Zaijie Sun, Qiang Guo, Xiaojun Liu, Kunming Cheng, Cheng Li
Journal: International Journal of Surgery (2024)

Wu, Haiyang; Sun, Zaijie; Guo, Qiang; Liu, Xiaojun; Cheng, Kunming; Li, Cheng Author Information
Time to IVT Treatment and Functional Outcomes in Acute Ischemic Stroke
Authors: Annahita Sedghi, Timo Siepmann
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
B-cell depletion in autoimmune diseases
Authors: Georg Schett, György Nagy, Gerhard Krönke, Dirk Mielenz
Journal: Annals of the Rheumatic Diseases (2024)

B cells have a pivotal function in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. In autoimmune disease, B cells orchestrate antigen presentation, cytokine production and autoantibody production, the latter via their differentiation into antibody-secreting plasmablasts and plasma cells. This article addresses the current therapeutic strategies to deplete B cells in order to ameliorate or potentially even cure autoimmune disease. It addresses the main target antigens in the B-cell lineage that are used for therapeutic approaches. Furthermore, it summarises the current evidence for successful treatment of autoimmune disease with monoclonal antibodies targeting B cells and the limitations and challenges of these approaches. Finally, the concept of deep B-cell depletion and immunological reset by chimeric antigen receptor T cells is discussed, as well as the lessons from this approach for better understanding the role of B cells in autoimmune disease.
Dispensing of Glucagon-Like Peptide-1 Receptor Agonists to Adolescents and Young Adults, 2020-2023
Authors: Joyce M. Lee, Mona Sharifi, Lauren Oshman, Dina H. Griauzde, Kao-Ping Chua
Journal: JAMA (2024)

This study uses data from US retail pharmacies to assess national GLP-1RA dispensing to adolescents and young adults from 2020-2023.
Management Challenges for Bioprosthetic Aortic Valve Failure
Authors: Vinay Guduguntla, Robert O. Bonow
Journal: JAMA Cardiology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Antihypertensive Medications and Eczematous Dermatitis in Older Adults
Authors: Morgan Ye, Leslie N. Chan, Ian Douglas, David J. Margolis, Sinéad M. Langan, Katrina Abuabara
Journal: JAMA Dermatology (2024)

Rates of physician-diagnosed eczema have been increasing among older adults, but little is known regarding the pathophysiologic processes and best treatments in this subgroup. Preliminary data suggest that medications-antihypertensive medications in particular-may contribute to eczematous dermatitis; however, there are limited population-based data on the proportion of eczematous dermatitis diagnoses among older adults that may be attributed to antihypertensive drugs.
Measuring Signs of Atopic Dermatitis in Clinical Practice
Authors: Michael E. Jacobson, Yael A. Leshem, Christian Apfelbacher, Phyllis I. Spuls, Louise A. A. Gerbens, Kim S. Thomas, Hywel C. Williams, Norito Katoh, Laura Howells, Jochen Schmitt, Stefanie Deckert, Rishi Seshadri, Eric L. Simpson
Journal: JAMA Dermatology (2024)

Importance Outcome measurement is an essential component of value-based health care and can aid patient care, quality improvement, and clinical effectiveness evidence generation. The Harmonising Outcome Measures for Eczema Clinical Practice initiative aims to identify a list of validated, feasible, outcome measurement instruments recommended to measure atopic dermatitis (AD) in the clinical practice setting. The clinical practice set is a list of instruments that clinicians can pick and choose from to suit their needs in the context of clinical care. Objective To recommend instruments to measure clinical signs of AD in clinical practice. Evidence Review Following the predefined roadmap, a mixed methods design was implemented and incorporated systematic reviews and qualitative consensus methods. Previous systematic reviews identified few clinical signs instruments with sufficient validation for recommendation. An updated systematic review evaluating the validity of clinical signs instruments informed an international meeting to reach consensus on recommended instruments to measure AD clinical signs in clinical practice. Consensus was defined as less than 30% disagreement. An in-person consensus exercise was held in Montreal, Canada, on October 16, 2022. The 34 attendees included patient and patient advocate research partners, health care professionals, researchers, methodologists, and industry representatives. Findings The updated systematic review found that the Eczema Area and Severity Index (EASI), Scoring Atopic Dermatitis, and objective Scoring Atopic Dermatitis were the only instruments that demonstrated sufficient performance in all assessed measurement properties. The modified EASI and Signs Global Assessment × Body Surface Area instruments were also recommended. The EASI, Validated Investigator Global Assessment, and Investigator’s Global Assessment multiplied by or measured concurrently with a body surface area measure achieved consensus in criteria and were adopted. Conclusions and Relevance This consensus statement by the Harmonising Outcome Measures for Eczema initiative suggests that when assessing and documenting clinical signs of AD, there are several valid and feasible instruments that can best fit a clinician’s specific practice needs. These instruments should improve and standardize the documentation of signs severity, help determine the effect of treatment, facilitate the generation of clinical effectiveness evidence, and enhance the implementation of value-based health care.
Phase I and Randomized Phase II Study of Ruxolitinib With Frontline Neoadjuvant Therapy in Advanced Ovarian Cancer: An NRG Oncology Group Study
Authors: Charles N. Landen, Ronald J. Buckanovich, Michael W. Sill, Robert S. Mannel, Joan L. Walker, Paul A. DiSilvestro, Cara A. Mathews, David G. Mutch, Marcia L. Hernandez, Lainie P. Martin, Erin Bishop, Sarah E. Gill, Mary E. Gordinier, Robert A. Burger, Carol Aghajanian, Joyce F. Liu, Kathleen N. Moore, Michael A. Bookman
Journal: Journal of Clinical Oncology (2024)

The interleukin-6/Janus kinase (JAK)/signal transducers and activators of transcription 3 axis is a reported driver of chemotherapy resistance. We hypothesized that adding the JAK1/2 inhibitor ruxolitinib to standard chemotherapy would be tolerable and improve progression-free survival (PFS) in patients with ovarian cancer in the upfront setting.
Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis
Authors: Mrigya Babuta, Caroline Morel, Marcelle de Carvalho Ribeiro, Charles Calenda, Martí Ortega-Ribera, Prashanth Thevkar Nagesh, Christopher Copeland, Yuan Zhuang, Yanbo Wang, Yeonhee Cho, Radhika Joshi, Viliam Brezani, Danielle Hawryluk, Aditi Ashish Datta, Jeeval Mehta, Imad Nasser, Gyongyi Szabo
Journal: Gut (2024)

Objective Alcohol use in metabolic dysfunction-associated steatohepatitis (MASH) is associated with an increased risk of fibrosis and liver-related death. Here, we aimed to identify a mechanism through which repeated alcohol binges exacerbate liver injury in a high fat-cholesterol-sugar diet (MASH diet)-induced model of MASH. Design C57BL/6 mice received either chow or the MASH diet for 3 months with or without weekly alcohol binges. Neutrophil infiltration, neutrophil extracellular traps (NETs) and fibrosis were evaluated. Results We found that alcohol binges in MASH increase liver injury and fibrosis. Liver transcriptomic profiling revealed differential expression of genes involved in extracellular matrix reorganisation, neutrophil activation and inflammation compared with alcohol or the MASH diet alone. Alcohol binges specifically increased NET formation in MASH livers in mice, and NETs were also increased in human livers with MASH plus alcohol use. We discovered that cell-free NETs are sensed via Nod-like receptor protein 3 (NLRP3). Furthermore, we show that cell-free NETs in vitro induce a profibrotic phenotype in hepatic stellate cells (HSCs) and proinflammatory monocytes. In vivo, neutrophil depletion using anti-Ly6G antibody or NET disruption with deoxyribonuclease treatment abrogated monocyte and HSC activation and ameliorated liver damage and fibrosis. In vivo, inhibition of NLRP3 using MCC950 or NLRP3 deficiency attenuated NET formation, liver injury and fibrosis in MASH plus alcohol diet-fed mice (graphical abstract). Conclusion Alcohol binges promote liver fibrosis via NET-induced activation of HSCs and monocytes in MASH. Our study highlights the potential of inhibition of NETs and/or NLRP3, as novel therapeutic strategies to combat the profibrotic effects of alcohol in MASH.
Heavy arch: from inflammatory bowel diseases to metabolic disorders
Authors: Timon E Adolph, Moritz Meyer, Almina Jukic, Herbert Tilg
Journal: Gut (2024)

Background Metabolic disorders and inflammatory bowel diseases (IBD) have captured the globe during Westernisation of lifestyle and related dietary habits over the last decades. Both disease entities are characterised by complex and heterogeneous clinical spectra linked to distinct symptoms and organ systems which, on a first glimpse, do not have many commonalities in clinical practice. However, experimental studies indicate a common backbone of inflammatory mechanisms in metabolic diseases and gut inflammation, and emerging clinical evidence suggests an intricate interplay between metabolic disorders and IBD. Objective We depict parallels of IBD and metabolic diseases, easily overlooked in clinical routine. Design We provide an overview of the recent literature and discuss implications of metabolic morbidity in patients with IBD for researchers, clinicians and healthcare providers. Conclusion The Western lifestyle and diet and related gut microbial perturbation serve as a fuel for metabolic inflammation in and beyond the gut. Metabolic disorders and the metabolic syndrome increasingly affect patients with IBD, with an expected negative impact for both disease entities and risk for complications. This concept implies that tackling the obesity pandemic exerts beneficial effects beyond metabolic health.
Risk of hypersensitivity pneumonitis and other interstitial lung diseases following organic dust exposure
Authors: Inge Brosbøl Iversen, Jesper Medom Vestergaard, Ioannis Basinas, Johan Ohlander, Susan Peters, Elisabeth Bendstrup, Jens Peter Ellekilde Bonde, Vivi Schlünssen, Finn Rasmussen, Zara Ann Stokholm, Michael Brun Andersen, Hans Kromhout, Henrik Albert Kolstad
Journal: Thorax (2024)

Background Organic dust is associated with hypersensitivity pneumonitis, and associations with other types of interstitial lung disease (ILD) have been suggested. We examined the association between occupational organic dust exposure and hypersensitivity pneumonitis and other ILDs in a cohort study. Methods The study population included all residents of Denmark born in 1956 or later with at least 1 year of gainful employment since 1976. Incident cases of hypersensitivity pneumonitis and other ILDs were identified in the Danish National Patient Register 1994–2015. Job exposure matrices were used to assign individual annual levels of exposure to organic dust, endotoxin and wood dust from 1976 to 2015. We analysed exposure-response relations by different exposure metrics using a discrete-time hazard model. Results For organic dust, we observed increasing risk with increasing cumulative exposure with incidence rate ratios (IRR) per 10 unit-years of 1.19 (95% CI 1.12 to 1.27) for hypersensitivity pneumonitis and 1.04 (95% CI 1.02 to 1.06) for other ILDs. We found increasing risk with increasing cumulative endotoxin exposure for hypersensitivity pneumonitis and other ILDs with IRRs per 5000 endotoxin units/m 3 -years of 1.55 (95% CI 1.38 to 1.73) and 1.09 (95% CI 1.00 to 1.19), respectively. For both exposures, risk also increased with increasing duration of exposure and recent exposure. No increased risks were observed for wood dust exposure. Conclusion Exposure-response relations were observed between organic dust and endotoxin exposure and hypersensitivity pneumonitis and other ILDs, with lower risk estimates for the latter. The findings indicate that organic dust should be considered a possible cause of any ILD. Trial registration number j.no.: 1-16-02-196-17
Intravital imaging: dynamic insights into liver immunity in health and disease
Authors: Yuting Wang, Felix Heymann, Moritz Peiseler
Journal: Gut (2024)

Inflammation is a critical component of most acute and chronic liver diseases. The liver is a unique immunological organ with a dense vascular network, leading to intense crosstalk between tissue-resident immune cells, passenger leucocytes and parenchymal cells. During acute and chronic liver diseases, the multifaceted immune response is involved in disease promoting and repair mechanisms, while upholding core liver immune functions. In recent years, single-cell technologies have unravelled a previously unknown heterogeneity of immune cells, reshaping the complexity of the hepatic immune response. However, inflammation is a dynamic biological process, encompassing various immune cells, orchestrated in temporal and spatial dimensions, and driven by multiorgan signals. Intravital microscopy (IVM) has emerged as a powerful tool to investigate immunity by visualising the dynamic interplay between different immune cells and their surroundings within a near-natural environment. In this review, we summarise the experimental considerations to perform IVM and highlight recent technological developments. Furthermore, we outline the unique contributions of IVM to our understanding of liver immunity. Through the lens of liver disease, we discuss novel immune-mediated disease mechanisms uncovered by imaging-based studies.
Sex-Related Differences in the Phenotype and Course of Inflammatory Bowel Disease: SEXEII Study of ENEIDA
Authors: Carla J. Gargallo-Puyuelo, Elena Ricart, Eva Iglesias, Ruth de Francisco, Javier P. Gisbert, Carlos Taxonera, Miriam Mañosa, Mariam Aguas Peris, Eva María Navarrete-Muñoz, Ana Sanahuja, Jordi Guardiola, Francisco Mesonero, Montserrat Rivero Tirado, Jesús Barrio, Isabel Vera Mendoza, Luisa de Castro Parga, Esther García-Planella, Xavier Calvet, María Dolores Martín Arranz, Santiago García, Beatriz Sicilia, Daniel Carpio, Eugeni Domenech, Fernando Gomollón, Lucía Márquez-Mosquera, Lucia Madero, María Esteve, David Monfort, Pilare Varela, Pablo Vega, Guillermo Alcaín Martínez, Iago Rodriguez-Lago, Orlando García-Bosh, Jose Lázaro Pérez Calle, Olga Merino, Mónica Sierra Ausin, Carlos Tardillo, Rufo Lorente Poyatos, Luis Ignacio Fernandez-Salazar, Mariana Fe García Sepulcre, Fernando Bermejo, Nuria Maroto Arce, Luis Bujanda, Joan Riera, Yolanda Ber, Ángel Ponferrada Díaz, Francesc BasCutrina, Pilar Martinez Montiel, Laura Ramos, Jordina Llaó, Manuel Barreiro- de Acosta, Cristina Rodriguez Gutierrez, Fernando Muñoz, Eva Sese, Rosa Blat, Jose M. Huguet, Ignacio Marín-Jiménez, Carlos Martínez-Flores, Manuel Van Domselaar, Alfredo J. Lucendo, Daniel Ginard, Margarita Menacho, Noemí Manceñido Marcos, Pedro Almela, Patricia Ramirez de la Piscina, Federico Argüelles-Arias, Carmen Muñoz Vilafranca, Elena Peña, Pau Gilabert Alvarez, Javier Santos Fernández, Ana Fuentes Coronel, Luis Hernández Villalba, Pilar Robledo Andres, Teresa Martínez Perez, Jesús Legido Gil, Hipólito Fernandez, Edgar Castillo Regalado, Lidia Buendía, Ana María Trapero Martinez, Carles Leal, Eduardo Iyo Miyashiro, Antonio García Herola, Santiago Frago, María Teresa Novella Duran, Victor Manuel Navas López, Isabel Nicolás de Prado, Paloma Bebia, Belén Botella, Rosa Ana Muñoz
Journal: Clinical Gastroenterology and Hepatology (2024)
Underwater Endoscopic Mucosal Resection Vs Conventional Endoscopic Mucosal Resection for Superficial Nonampullary Duodenal Epithelial Tumors in the Western Setting
Authors: Rui Morais, José Amorim, Renato Medas, Bernardo Sousa-Pinto, João Santos-Antunes, Romain Legros, Jérémie Albouys, Frédéric Moll, Margarida Marques, Filipe Vilas-Boas, Eduardo Rodrigues-Pinto, Irene Gullo, Fátima Carneiro, Elisa Gravito Soares, Pedro Amaro, Pedro Mesquita, Jaime Rodrigues, Gianluca Andrisani, Sandro Sferrazza, Sara Archer, Ricardo Kuttner-Magalhães, Francisco Manzano, Enrique Rodríguez de Santiago, Alessandro Rimondi, Alberto Murino, Edward Despott, Mathieu Pioche, Jérémie Jacques, Guilherme Macedo
Journal: Clinical Gastroenterology and Hepatology (2024)
Establishment of human induced pluripotent stem cell-derived hepatobiliary organoid with bile duct for pharmaceutical research use
Authors: Luyao Wang, Yuta Koui, Kazuko Kanegae, Taketomo Kido, Miwa Tamura-Nakano, Shigeharu Yabe, Kenpei Tai, Yoshiko Nakajima, Hiroyuki Kusuhara, Yasuyuki Sakai, Atsushi Miyajima, Hitoshi Okochi, Minoru Tanaka
Journal: Biomaterials (2024)
Engineering the microenvironment of P450s to enhance the production of diterpenoids in Saccharomyces cerevisiae
Authors: Yatian Cheng, Linglong Luo, Hao Tang, Jian Wang, Li Ren, Guanghong Cui, Yujun Zhao, Jinfu Tang, Ping Su, Yanan Wang, Yating Hu, Ying Ma, Juan Guo, Luqi Huang
Journal: Acta Pharmaceutica Sinica B (2024)

Cytochrome P450 enzymes play a crucial role as catalysts in the biosynthesis of numerous plant natural products (PNPs). Enhancing the catalytic activity of P450s in host microorganisms is essential for the efficient production of PNPs through synthetic biology. In this study, we engineered