Some Observations Concerning a Possible Insulin-Inhibiting Substance in Urine
Authors: E. M. Watson, W. S. Dick
Journal: Annals of Internal Medicine (1933)

Article1 March 1933Some Observations Concerning a Possible Insulin-Inhibiting Substance in UrineE. M. WATSON, M.D., F.R.C.P., W. S. DICK, M.D., M.Sc.E. M. WATSON, M.D., F.R.C.P.Search for more papers by this author, W. S. DICK, M.D., M.Sc.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-9-1171 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent investigations have pointed to the existence in the blood of a substance which is capable of inhibiting the activity of insulin. Karelitz, Cohen, and Leader,1as the outcome of an attempt to discover the cause of insulin resistance in a patient with diabetes mellitus, observed that the blood of diabetics, and to a lesser extent that of normal persons, apparently possessed something which was antagonistic in its action to insulin. While this inhibiting property was demonstrated by blood plasma, it was exhibited to a more marked degree by laked red blood cells. Their data were elicited by studying the...References1 KARELITZCOHENLEADER SPSD: Insulin inactivation by human blood cells and plasma in vitro; effect of normal and of diabetic blood on insulin action, Arch. Int. Med., 1930, xlv, 546-558. Insulin inactivation by human blood cells and plasma in vitro; effect of infection on insulin, ibid., 1930, xlv, 690-701. CrossrefGoogle Scholar2 WARREN S: The pathology of diabetes mellitus, 1930, Lea and Febiger, Philadelphia. Google Scholar3 MAURIACAUBERTIN PE: Sur le pouvoir de neutralisation du sang de sujets diabétiques et non diabétiques vis-a-vis de l'insuline, Compt. rend. Soc. de biol., 1928, xcviii, 233-235. Le pouvoir de neutralisation du sang vis-a-vis de l'insuline est d'origine globulaire, ibid., 1928, xcviii, 235-237. 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Author, Article, and Disclosure InformationAffiliations: London, Canada*Received for publication June 29, 1932.†From the Division of Pathological Chemistry, University of Western Ontario Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1933Volume 6, Issue 9Page: 1171-1179KeywordsBloodBlood plasmaDiabetes mellitusInsulinInsulin resistanceRed blood cells ePublished: 1 December 2008 Issue Published: 1 March 1933 PDF downloadLoading ...