tbuckley/cabot-search huggingface dataset:
Four dimension analysis of heat generation during Ho:YAG and thulium fiber laser activation: An in vitro thermographic study
Authors: D. Robesti, C. Corsini, L. Candela, M. Fantin, L. Villa, I.K. Goumas, S. Proietti, G. Giusti, C. Cracco, C. Soffocone, O. Traxer, E. Keller, F. Montorsi, A. Salonia, P. Saccomandi, E. Ventimiglia
Journal: European Urology (2024)
Long-term functional outcomes of voiding after hypospadias repair: A single-center retrospective comparative study
Authors: H. Nishio, K. Mizuno, T. Sakata, D. Matsumoto, T. Kato, H. Kamisawa, S. Kurokawa, A. Nakane, T. Maruyama, T. Yasui, Y. Hayashi
Journal: European Urology (2024)
The outcomes of inflatable penile prosthesis implantation in the context of GGAS in AFAB patients: A comparative study between cis-gender modified and single cylinder transgender PP
Authors: M. Falcone, M. Preto, F. Peretti, L. Cirigliano, I. Ferro, N. Plamadeala, M. Scavone, P. Gontero
Journal: European Urology (2024)
Comparing detection rates of PSMA PET/CT target biopsy vs. mpMRI targeted biopsy in detection of clinically significant prostate cancer
Authors: F. Piramide, E. Cisero, D. Amparore, E. Checcucci, S.T. De Cillis, A. Piana, G. Volpi, M. Sica, P. Verri, M. Burgio, J. Meziere, A. Quarà, G. Busacca, A. Sterrantino, M. Ortenzi, A.G. Mesterca, M. Mandaletti, G. Bignante, D. Garino, F. Rosi, M. Manfredi, M. Di Dio, C. Fiori, F. Porpiglia
Journal: European Urology (2024)
WHO model list of essential in vitro diagnostics: strengthening diagnostics capacity to transform health care for all
Authors: Dario Trapani, Patricia J Garcia, Lee Schroeder, Rashad Abdul-Ghani, Amina Hansali, Paulinus Nnamdi Offutalu, William Sewell, Sadia Shakoor, Lyu Yunfeng, Naofumi Hashimoto, Francis G Moussy, Ana Aceves Capri, Kenneth Fleming
Journal: The Lancet Global Health (2024)
Transperineal vs. transrectal MRI/TRUS fusion biopsy: A comparative analysis of index cancer characterization in radical prostatectomy specimens
Authors: M. Kaneko, D. Paralkar, L.S. Ramacciotti, D.S. Jadvar, G.E. Cacciamani, M. Hopstone, H. Djaladat, M. Desai, M. Aron, M. Aron, I.S. Gill, A.L. Abreu
Journal: European Urology (2024)
Incidence of significant prostate cancer after positive MRI and negative targeted and systematic biopsies
Authors: C. Siebert, T.A. Nguyen, A. Fourcade, A. Zambon, K. Saout, C. Deruelle, V. Joulin, V. Tissot, L. Doucet, G. Fournier, A. Valeri
Journal: European Urology (2024)
The impact of radical prostatectomy versus radiation therapy on cancer-specific mortality for patients with localized prostate cancer and positive nodal disease: An analysis of other cause mortality weighted cohort
Authors: S.A. Tinsley, A. Stephens, F. Marco, G. Chiarelli, G.O. Cirulli, M. Davis, N. Corsi, A. Sood, N. Buffi, G. Lughezzani, C. Bettocchi, A. Salonia, A. Briganti, F. Montorsi, G. Carrieri, C. Rogers, F. Abdollah
Journal: European Urology (2024)
Quality of information and appropriateness of Open AI outputs for lithiasis management
Authors: A. Guercio, L. Sarcinelli, M. Romagoli, S. Riolo, A. Nacchia, R. Lombardo, G. Tema, G. Guarnotta, A. Cicione, A. Pastore, Y. Al Salhi, G. Franco, A. Sciarra, A. Tubaro, A. Carbone, C. De Nunzio
Journal: European Urology (2024)
Precut over a pancreatic stent using the marking method to aid biliary cannulation in a patient with Roux-en-Y reconstruction
Authors: Yuichi Takano, Naoki Tamai, Jun Noda, Tetsushi Azami, Fumitaka Niiya, Fumiya Nishimoto, Masatsugu Nagahama
Journal: Endoscopy (2024)

Despite the remarkable development of balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography (ERCP), deep biliary cannulation in patients with surgically altered anatomy remains challenging [1] [2]. We report a case where biliary cannulation was successfully achieved via precutting over a pancreatic stent using the marking method [3].
Protein arginine methyltransferases refine the classification of clear cell renal cell carcinoma with distinct prognosis and tumor microenvironment characteristics
Authors: Y. Shiqi, T. Xi, A. Anwaier, S. Jiaqi, Z. Shuxuan, Q. Yuanyuan, X. Wenhao, Z. Hailiang, Y. Dingwei
Journal: European Urology (2024)
Oncological outcomes and preoperative predictors of disease recurrence in upper tract urothelial carcinoma patients treated with distal ureterectomy: Results from a large national cohort
Authors: M. Rosazza, F. Soria, S. Livoti, D. Dutto, F. Colucci, E. De Lorenzis, N. Foschi, G. Mantica, F. Ambrosini, R. Campi, S. Serni, L. Moscardi, F. Chiancone, D. Amparore, G. Lucarelli, F. Lasorsa, P. Gontero
Journal: European Urology (2024)
The clinical utility of contralateral systematic biopsies in men with unilateral MRI foci undergoing office-based transperineal MRI-guided biopsies
Authors: L. Boesen, N. Nørgaard, R. Bisbjerg, M.M.N. Al-Hamadani, C.S. Sjölin, V.B. Løgager
Journal: European Urology (2024)
Re-do robot-assisted vena cava thrombectomy: Feasibility and results
Authors: G. Margue, A. Khaddad, F. Luyckx, C. Allenet, M. Yacoub, V. Estrade, E. Alezra, G. Capon, F. Bladou, G. Robert, M. Gross-Goupil, J.C. Bernhard
Journal: European Urology (2024)
Challenges in E-health: The effect of digitalisation of frequency voiding charts on compliance in paediatric patients. Randomised controlled trial comparing digital and paper frequency voiding charts.
Authors: L.L. de Wall, E.A.M. Kragt, E.H.M. van de Wetering, J.G.L. Cobussen-Boekhorst, J. Mantel-Van Stel, B.B.M. Kortmann, W.F.J. Feitz, C.M.H.H.T. Bootsma-Robroeks
Journal: European Urology (2024)
Snap diagnosis: Pilot study of artificial intelligence powered smartphone application for penile cancer detection from the comfort of your home
Authors: J. Liu, J.S. O Brien, K. Nandakishor, K. Chen, J. Teh, B.D. Kelly, T. Manning, S. Niranjan, D.G. Murphy, D. Bolton, J. Chee, P. Marimuthu, N. Lawrentschuk
Journal: European Urology (2024)
Artificial intelligence based personalized oncological outcome prediction model for upper urinary tract urothelial carcinoma after radical nephroureterectomy: Development and multi-center validation
Authors: D. Kim, K.H. Nam, H.Y. Lee, B. Lim, D. Kim, Y. Jeong, I.G. Jeong, J.J. Park, D. You, J.H. Hong, C. Song, J.H. Ku, B. Hong, H. Ahn, H. Kim, J. Suh
Journal: European Urology (2024)
Outcomes after primary retroperitoneal lymph node dissection in men with stage 2 non-seminomatous germ cell tumour, a multicenter retrospective cohort study
Authors: L. Antonelli, A. Heidenreich, A. Bagrodia, N. Branger, W. Cazzaniga, T.N. Clinton, S. Daneshmand, H. Djaladat, S. Eggener, R.J. Hamilton, M. Ho, W.J. Sexton, S. Nazzani, D. Nicol, N. Nicolai, K. Olson, P. Paffenholz, J. Porter, N. Singla, S.P. Stroup, I. Tachibana, A. Terbuch, C. Cary, C.D. Fankhauser
Journal: European Urology (2024)
Diagnostic accuracy of Multiparametric Magnetic Resonance Imaging (mpMRI), targeted and systematic prostate biopsy for the detection of cribriform growth pattern in patients with clinical-localized prostate cancer
Authors: A. Piasentin, G. Rossin, F. Traunero, L. Ongaro, G. Sernaglia, A. Biasatti, M. Rizzo, A. Zucchi, R. Bartoletti, G. Liguori, M. Bertolotto, C. Trombetta, F. Claps
Journal: European Urology (2024)
Size of lymph node metastases in prostate cancer patients undergoing radical prostatectomy: Implication for imaging and oncologic follow-up of 2705 lymph node positive patients
Authors: F. Falkenbach, M. Kachanov, S-R. Leyh-Bannurah, T. Maurer, S. Knipper, D. Köhler, M. Graefen, G. Sauter, L. Budäus
Journal: European Urology (2024)
Third implantation of artificial urinary sphincter in male patients with two previous explantations : Is it doomed to failure?
Authors: F. Meyer, J. Cotte, L. Bento, G. Nicaud, A. Dubois, H. Werth, C. Saussine, E. Chartier-Kastler, X. Gamé, J.F. Hermieu, F. Desgrandchamps, B. Peyronnet, J-N.L. Cornu
Journal: European Urology (2024)
Impact of nerve-sparing on urinary continence following robot-assisted radical prostatectomy: Results from a high-volume tertiary care hospital
Authors: A. Pissavini, G. Sorce, M. Ticonosco, N. Frego, C. Collà Ruvolo, S. Rebuffo, M. Belmonte, R. De Groote, G. De Naeyer, F. D Hondt, A. Mottrie
Journal: European Urology (2024)
Risk of acute urinary retention After-HoLEP – results from a prospective trial
Authors: P. Capogrosso, G. Rosiello, E. Ventimiglia, E. Pozzi, F. Belladelli, A. Bertini, N. Schifano, L. Candela, F. Dehò, A. Briganti, A. Salonia, F. Montorsi
Journal: European Urology (2024)
Primary retroperitoneal germ-cell tumors (pR-GCT): Evaluation of treatment outcomes of an international collaboration (PRIMERE study-IGG05)
Authors: S. Nazzani, P. Giannatempo, V. Bernasconi, C. Silvani, M. Mego, I. Taglialatela, D. Bimbatti, S. Secondino, U. De Giorgi, M. Claps, D. Biasoni, M. Catanzaro, M. Zimatore, T. Torelli, S. Stagni, A. Macchi, A. Tesone, P. Pedrazzoli, U. Basso, G. Procopio, F. De Braud, N. Nicolai
Journal: European Urology (2024)
The impact of systematic sampling on prostate biopsy results
Authors: H. Ayerra Pérez, J.F. Barba Abad, N. Herrera Aranda, P. Arce Cuartango, P. San Martín Vilarino, I. Duque Martínez, N. García De Garayo Pires, R. Pinto Martín, E. Tolosa Eizaguirre, J. Moctezuma Velázquez, J.M. Campà Bortoló, J. Extramiana Cameno
Journal: European Urology (2024)
The European network for the study of adrenal tumors staging system (2015): A North American validation
Authors: L.M.I. Jannello, R.B. Incesu, S. Morra, L. Scheipner, A. Baudo, M. de Angelis, C. Siech, Z. Tian, S. Luzzago, F.A. Mistretta, M. Ferro, F. Saad, S.F. Shariat, F.K.H. Chun, A. Briganti, D. Tilki, S. Ahyai, L. Carmignani, N. Longo, O. de Cobelli, G. Musi, P.I. Karakiewicz
Journal: European Urology (2024)
Impact of positive surgical margin after radical and partial nephrectomy for renal cell carcinoma: A multicenter analysis
Authors: C. Saitta, C. Cerrato, U. Capitanio, R. Autorino, E. Beatrici, S. Pandolfo, M. Meagher, A. Antonelli, A. Veccia, D. Amparore, G. Simone, G. Tuderti, G. Lughezzani, N. Buffi, H. Tanaka, D. Pati, V. Master, Y. Fujii, F. Porpiglia, F. Montorsi, I. Derweesh
Journal: European Urology (2024)
Artificial intelligence in andrology. Can we predict long-term erectile dysfunction following COVID-19?
Authors: F. Natal, M.C. Conde Redondo, N. Sierrasesumaga Martin, A. Garcia Vina, C. Marfil Pena, A. Bahillo Martinez, A. Tamayo Velasco, M. Jojoa, E. Tamayo Gomez
Journal: European Urology (2024)
Endoscopic submucosal dissection using ultrathin endoscope for early gastric cancer progressing from pyloric ring to bulb
Authors: Takeshi Yasuda, Osamu Dohi, Naoto Iwai, Hiromu Kutsumi, Yoshito Itoh
Journal: Endoscopy (2024)

Endoscopic submucosal dissection (ESD) for early-stage gastric cancer (GC) has been widely adopted. However, GC's progression from the pyloric ring to the duodenal bulb remain challenging. In the antegrade approach, treating the anal side is difficult, whereas in the retroflex approach, the narrow space of the duodenal bulb poses a risk of perforation when standard-diameter scopes are used [1] [2]. Recently, ESD with ultrathin endoscopes has been reported [3]; moreover, devices suitable for procedures with ultrathin endoscopes have become commercially available [4]. We report an efficient and safe ESD for GC that extended into the duodenal bulb by combining the aforementioned devices.
Prospective and comparative study to evaluate the impact of the male masturbation device Controleyac by Androgenital on premature ejaculation: Functional results, safety, and satisfaction assessment
Authors: M. Alonso Isa, B. García Gómez, E. Garcia Rojo, H. Pena Vallejo, M.A.D.P. Caro González, S. Juste Álvarez, C. Calzas Montalvo, R. Sopena Sutil, A. Rodríguez Antolín, J. Romero Otero
Journal: European Urology (2024)
Comparative analysis of early functional outcomes following the hood technique vs. standard nerve sparing technique during RARP
Authors: N. Khanmammadova, A.D. Cumpanas, D. Jiang, R. Gevorkyan, M. Epino, T. Chu, A. Gao, A.S. Afyouni, M. O’leary, T.T. Nguyen, C. Fung, C. Nguyen, S.N. Ali, M. Shahait, D.I. Lee
Journal: European Urology (2024)
Impact of laser energy and rate of enucleated prostate tissue in the early functional outcomes of Holmium Laser Enucleation of Prostate (HOLEP)
Authors: S. Fernández-Pello Montes, I. Gonzalez, L. Rodríguez Villamil, R. Blanco, L. Martín, M. Rivas
Journal: European Urology (2024)
Theranostics in chemotherapy resistant MIBC by instillation of FAP &amp; CXCR4 radioligands into the bladder - the Bladder BRIDGister experience
Authors: R. Wirtz, L. Kastner, F. Friedersdorff, T. Schlomm, D. Barski, T. Otto, M. Waldner, J. Graff, E. Veltrup, F. Linden, M. Schwandt, R. Hake, S. Eidt, J. Roggisch, C. Rieger, S. Koch, T. Klatte, T. Ecke, A. Heidenreich, L. Greifenstein, R.P. Baum
Journal: European Urology (2024)
Single-cell trajectory analysis reveals distinct differentiation of epithelial cells highlighting a more aggressive phenotype in HPV-negative and TP53 mutated penile cancer
Authors: L. Elst, G. Philips, A. Bassez, K. Vandermaesen, B. Boeckx, L. Spans, I. Vanden Bempt, G. Jacomen, A-S. Van Rompuy, M. Baldewijns, D. Lambrechts, M. Albersen
Journal: European Urology (2024)
Direct comparison of novel vaginal meshes developed for use in the treatment of stress urinary incontinence in an improved pre-clinical rabbit model
Authors: S. Ozturk, S. Roman Regueros, D. Zeybek, O. Bozdemir, M. Gultekinoglu-Bayram, V. Hearnden, S. Macneil, K. Ulubayram, N. Mangir
Journal: European Urology (2024)
BRAF V600E mutation promoted excess of cortisol secretion in adrenal cortical adenoma
Authors: K. Numakura, Y. Muto, Y. Sugiyama, M. Kobayashi, Y. Sekine, S. Kashima, R. Yamamoto, T. Nara, M. Huang, M. Saito, S. Narita, T. Habuchi
Journal: European Urology (2024)
Predictors of early continence in robot-assisted radical prostatectomy: The role of prostate lobe asymmetry
Authors: F. Di Bello, S. Morra, G. Pezone, C. Collà Ruvolo, A. Fraia, R. La Rocca, L. Napolitano, M. Creta, N. Longo, G. Califano
Journal: European Urology (2024)
TROP-2 – a promising new therapeutic target in penile squamous cell carcinoma
Authors: R. Weiten, C. Kessler, C. Meisl, H.E. Spohn, E. Storz, D. Pfister, T. Nestler, Y. Tolkach, F. Linden, R. Wirtz, M. Von Brandenstein, P. Krausewitz, A. Heidenreich
Journal: European Urology (2024)
miRNA as a liquid biomarker to detect malignancy in small testicular masses
Authors: J. Chavarriaga, C. Langleben, J. Lobo, L. Nappi, G.M. Yousef, S. Janfaza, N.T. Tavares, Q. Ding, A. Bobrowski, S. Prendeville, L. Anson-Cartwright, C. Jeronimo, H. Wagner, K. Jarvi, M. O’malley, R. Leao, K. Lajkosz, R. Hamilton
Journal: European Urology (2024)
Transperineal biopsies using micro-ultrasound for prostate cancer
Authors: M.E. Rodríguez Socarrás, J.D. Guzman Barraza, J. Reinoso Elbers, J.A. Gomez Rivas, D. Carrion Monsalve, L. Llanes Gonzalez, J. Fernandez Del Alamo, S. Ruiz Grana, V. Cuadros Rivera, F. Gomez Sancha
Journal: European Urology (2024)
Robot-assisted sacrocolpopexy versus trans-vaginal prolapse repair: Impact on lower bowel tract function
Authors: A.L. Pastore, A. Antonioni, P.P. Suraci, O.A. Rera, M.B. Sequi, F.M. Valenzi, D. Graziani, A. Martoccia, G. Martino, F. Gianfrancesco, S. Scalzo, A. Fuschi, Y. Al Salhi, A. Sciarra, E. De Berardinis, R. Lombardo, C. De Nunzio, A. Carbone, M. Cervigni
Journal: European Urology (2024)
Effect of pregabalin on catheter-related bladder discomfort in patients undergoing transurethral resection of bladder tumor
Authors: B. Mosbahi, A. Hariz, C. Khalifa, H. Fakhfakh, K. Chaker, Y. Ouanes, M.A. Madani, J. Karmous, M. Bibi, K. Mrad Dali, M. Rahoui, Y. Nouira, A. Ammous
Journal: European Urology (2024)
Endoscopic intermuscular dissection of an undetermined submucosal lesion with adaptive traction to obtain a free vertical margin
Authors: Louis-Jean Masgnaux, Jean Grimaldi, Valerie Hervieu, Timothée Wallenhorst, Jérôme Rivory, Jérémie Jacques, Mathieu Pioche
Journal: Endoscopy (2024)

Endoscopic submucosal dissection (ESD) is a well-established technique for resecting superficial gastrointestinal neoplasms [1]. However, achieving clear vertical margins for submucosal lesions, such as neuroendocrine tumors, can be intricate [2]. The endoscopic intermuscular dissection (EID) method, which involves dissection between the two muscular layers of the rectum, was first developed to treat superficial tumors with vertical extension (T1) [3]. We think this technique could be useful to obtain free vertical margins for submucosal tumors.
Train the trainers for the delivery of proficiency based progression training by the european robotic surgical section fellowship centers
Authors: N. Frego, M. Ticonosco, S. Puliatti, E. Mazzone, R. De Groote, A. Breda, H. Van Der Poel, C. Wagner, G. Sorce, C. Collà Ruvolo, S. Rebuffo, M. Belmonte, A. Pissavini, A. Mottrie, A. Gallagher
Journal: European Urology (2024)
Human Papillomavirus (HPV) does not modify the prognostic significance of tumour stage and grade of differentiation in penile carcinoma. A retrospective study spanning 50 years from a Norwegian tertiary centre
Authors: C.A. Moen, I.M. Nordanger, T.K. Thorkelsen, A. Honoré, P. Juliebø-Jones, L. Bostad, C. Beisland
Journal: European Urology (2024)
No-touch endoscopic full-thickness resection using reopenable-clip over-the-line method for gastric gastrointestinal stromal tumor
Authors: Hitoshi Mori, Noriya Uedo, Satoki Shichijo
Journal: Endoscopy (2024)

With advancement of endoscopic resection and wound closure techniques, endoscopic resection of gastric gastrointestinal stromal tumors (GISTs) has evolved rapidly in recent years. However, concerns remain regarding the oncologic safety of this procedure, particularly the risk of tumor injury and the adequacy of the resection margins. To solve these problems, the no-touch endoscopic full-thickness resection (EFTR) technique, in which the tumor is removed with a 0.5–1.0-cm resection margin of the muscularis propria, has recently been proposed [1].
Novel peptide-based oncolytic vaccine for enhancement of adaptive antitumor immune response via co-engagement of innate Fcγ and Fcα receptors
Authors: Sara Feola, Firas Hamdan, Salvatore Russo, Jacopo Chiaro, Manlio Fusciello, Michaela Feodoroff, Gabriella Antignani, Federica D'Alessio, Riikka Mölsä, Virpi Stigzelius, Paolo Bottega, Sari Pesonen, Jeanette Leusen, Mikaela Grönholm, Vincenzo Cerullo
Journal: Journal for ImmunoTherapy of Cancer (2024)

Background Cancer immunotherapy relies on using the immune system to recognize and eradicate cancer cells. Adaptive immunity, which consists of mainly antigen-specific cytotoxic T cells, plays a pivotal role in controlling cancer progression. However, innate immunity is a necessary component of the cancer immune response to support an immunomodulatory state, enabling T-cell immunosurveillance. Methods Here, we elucidated and exploited innate immune cells to sustain the generation of antigen-specific T cells on the use of our cancer vaccine platform. We explored a previously developed oncolytic adenovirus (AdCab) encoding for a PD-L1 (Programmed-Death Ligand 1) checkpoint inhibitor, which consists of a PD-1 (Programmed Cell Death Protein 1) ectodomain fused to an IgG/A cross-hybrid Fc. We coated AdCab with major histocompatibility complex (MHC-I)-restricted tumor peptides, generating a vaccine platform (named PeptiCab); the latter takes advantage of viral immunogenicity, peptide cancer specificity to prime T-cell responses, and antibody-mediated effector functions. Results As proof of concept, PeptiCab was used in murine models of melanoma and colon cancer, resulting in tumor growth control and generation of systemic T-cell-mediated antitumor responses. In specific, PeptiCab was able to generate antitumor T effector memory cells able to secrete various inflammatory cytokines. Moreover, PeptiCab was able to polarize neutrophils to attain an antigen-presenting phenotype by upregulating MHC-II, CD80 and CD86 resulting in an enhanced T-cell expansion. Conclusion Our data suggest that exploiting innate immunity activates T-cell antitumor responses, enhancing the efficiency of a vaccine platform based on oncolytic adenovirus coated with MHC-I-restricted tumor peptides.
Th2 response drives itch in dystrophic epidermolysis bullosa pruriginosa: A case-control study
Authors: Marieta Papanikolaou, Leigh Nattkemper, Natashia Benzian-Olsson, Lu Liu, Alyson Guy, Han Lu, Tendai Kadiyirire, Ping-Chen Hou, Wilson Aala, Sonia Serrano, Rashida Pramanik, Nina Walters, Konstantina Dimitrakopoulou, Su Lwin, Emily Kalfas, Jose Satoc, Roman Laddach, Domenico Cozzetto, Bjorn Thomas, Evangelia Kesidou, Ellie Rashidghamat, Guy Orchard, Edel A O'Toole, Chao-Kai Hsu, Mansoor Saqi, Martin Steinhoff, Alexandros Onoufriadis, Gil Yosipovitch, Hannah Gould, Jemima E Mellerio, John A McGrath
Journal: Journal of the American Academy of Dermatology (2024)
Prospective per-target analysis of the added value of probe-tethered access cannulas in cognitive transperineal prostate biopsy of MRI targets
Authors: L. Orecchia, S. Germani, G. Colalillo, A. Fasano, M. Ricci, E. Rosato, A.D. Asimakopoulos, S. Albisinni, E. Finazzi Agrò, R. Miano
Journal: European Urology (2024)
Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations
Authors: Kasit Chatsirisupachai, João Pedro de Magalhães
Journal: Ageing Research Reviews (2024)

The accumulation of somatic mutations is a driver of cancer and has long been associated with ageing. Due to limitations in quantifying mutation burden with age in non-cancerous tissues, the impact of somatic mutations in other ageing phenotypes is unclear. Recent advances in DNA sequencing technologies have allowed the large-scale quantification of somatic mutations in ageing tissues. These studies have revealed a gradual accumulation of mutations in most normal tissues with age as well as a substantial clonal expansion driven mostly by cancer-related mutations. Nevertheless, it is difficult to envision how the burden and stochastic nature of age-related somatic mutations identified so far can explain most ageing phenotypes that develop gradually. Studies across species have also found that longer-lived species have lower somatic mutation rates, though these could be due to selective pressures acting on other phenotypes such as perhaps cancer. Recent studies in patients with higher somatic mutation burden and no signs of accelerated ageing further question the role of somatic mutations in ageing. Overall, with a few exceptions like cancer, recent DNA sequencing studies and inherited mutations do not support the idea that somatic mutations accumulating with age drive ageing phenotypes, and the phenotypic role, if any, of somatic mutations in ageing remains unclear.
Dual‐Targeting Nanovesicles Carrying CSF1/CD47 Identified from Single‐Cell Transcriptomics of Innate Immune Cells in Heart Transplant for Alleviating Acute Rejection (Adv. Healthcare Mater. 7/2024)
Authors: Zhanxue Xu, Xiaofan Mao, Xingyu Lu, Peilin Shi, Jingping Ye, Xinrui Yang, Qingling Fu, Chao He, Dandan Su, Yichu Nie, Longshan Liu, Changxi Wang, Benjie Zhou, Wei Luo, Fang Cheng, Hongbo Chen
Journal: Advanced Healthcare Materials (2024)
MDSC-targeting gold nanoparticles enhance PD-1 tumor immunotherapy by inhibiting NLRP3 inflammasomes
Authors: Yangyang Zhu, Pin Chen, Bochuan Hu, Suqin Zhong, Kai Yan, Yu Wu, Shanshan Li, Yinyin Yang, Zexin Xu, Yutong Lu, Ying Ouyang, Hui Bao, Weiguang Gu, Longping Wen, Yunjiao Zhang
Journal: Biomaterials (2024)