THE DESTRUCTION AND ELIMINATION OF RENIN IN THE DOG
Authors: B. A. Houssay, E. Braun-Menendez, L. Dexter
Journal: Annals of Internal Medicine (1942)

Article1 September 1942THE DESTRUCTION AND ELIMINATION OF RENIN IN THE DOGB. A. HOUSSAY, E. BRAUN-MENENDEZ, L. DEXTERB. A. HOUSSAY, E. BRAUN-MENENDEZ, L. DEXTERAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-3-461 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTigerstedt and Bergmann1described a pressor substance, renin, which is found in kidney but not in other organs and which has a prolonged pressor effect when injected intravenously. Kohlstaedt and Page2showed that purified renin had no vasoconstrictor action when perfused through a rabbit's ear but that it became active when mixed with blood colloids. This has been corroborated by others.3Braun-Menendez, Fasciolo, Leloir, and Muñoz4, 5, 3identified a pressor and vasoconstrictor substance, which they called hypertensin, in the venous blood of ischemic kidneys and showed that the same substance could be obtained in vitro by incubation of renin...Bibliography1. TIGERSTEDTBERGMANN RPG: Niere und Kreislauf, Skand. Arch. f. Physiol., 1898, viii, 223. CrossrefGoogle Scholar2. KOHLSTAEDTHELMERPAGE KGOMIH: Activation of renin by blood colloids, Proc. Soc. Exper. Biol. and Med., 1938, xxxix, 214. CrossrefGoogle Scholar3. BRAUN-MENENDEZFASCIOLOLELOIRMUÑOZ EJCLFJM: The substance causing renal hypertension, Jr. Physiol., 1940, xcviii, 283. CrossrefGoogle Scholar4. BRAUN-MENENDEZFASCIOLOLELOIRMUÑOZ EJCLFJM: La substancia hipertensora de la sangre del riñon isquemiado, Rev. Soc. argent. de biol., 1939, xv, 420. Google Scholar5. MUÑOZBRAUN-MENENDEZFASCIOLOLELOIR JMEJCLF: Hypertensin: the substance causing renal hypertension, Nature, 1939, cxliv, 980. CrossrefGoogle Scholar6. PAGEHELMER IHOM: A crystalline pressor substance (angiotonin) resulting from the reaction between renin and renin-activator, Jr. Exper. Med., 1940, lxxi, 29. CrossrefGoogle Scholar7. MUÑOZBRAUN-MENENDEZFASCIOLOLELOIR JMEJCLF: Mechanism of renal hypertension, Am. Jr. Med. Sci., 1940, cc, 608. CrossrefGoogle Scholar8. KOHLSTAEDTPAGE KGIH: Production of renin by constricting renal artery of an isolated kidney perfused with blood, Proc. Soc. Exper. Biol. and Med., 1940, xliii, 136. CrossrefGoogle Scholar9. LELOIRMUÑOZBRAUN-MENENDEZFASCIOLO LFJMEJC: La secreción de renina y la formación de hipertensina, Rev. Soc. argent. de biol., 1940, xvi, 75. Google Scholar10. LELOIRMUÑOZBRAUN-MENENDEZFASCIOLO LFJMEJC: Dosaje de la renina, Rev. Soc. argent. de biol., 1940, xvi, 635. Google Scholar11. FASCIOLOLELOIRMUÑOZBRAUN-MENENDEZ JCLFJME: La hipertensinasa: su dosaje y distribución, Rev. Soc. argent. de biol., 1940, xvi, 643. Google Scholar12. DEXTERBRAUN-MENENDEZ LE: La eliminación de renina en la orina, Rev. Soc. argent. de biol., 1941, xvii, 394. Google Scholar13. FASCIOLO JC: Papel de las glandulas adrenales en la génesis de la hipertensión arterial por isquemia renal, Rev. Soc. argent. de biol., 1938, xiv, 25. Google Scholar14. FASCIOLO JC: L'hypertension artérielle par ischemie rénale ne depend pas des surrénales, Compt. rend. Soc. de biol., 1938, cxxviii, 1130. Google Scholar15. FASCIOLO JC: Hipertensión arterial nefrógena; estudio experimental, Tesis Doct. Med., Buenos Aires, 1939. Google Scholar16. HOUSSAY BA: Mecanismo de acción de la secreción hipertensora del riñon, Medicina, 1941, i, 167. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 13, 1941.From the Institute of Physiology, Faculty of Medical Sciences, Buenos Aires, Argentina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe prolonged pressor response to renin in the nephrectomized rat.RENIN INACTIVATION IN VITRO IN PREGNANT AND POST PARTUM RABBIT UTERINE AND KIDNEY TISSUEStudies on ReninArterial and Urinary Renin ActivityRenin and Acute Circulatory Renal Failure in the RabbitUrinary renin and norepinephrine excretion in dogs after unilateral renal artery constrictionII. PodiumsgesprächErh�hte Reninausscheidung im Urin der isch�mischen Niere bei experimenteller einseitiger Nierenarterienstenose des HundesHepatic Clearance of Renin in Canine Experimental Models for Low- and High-Output Heart FailureDie Hypotonie unter besonderer Berücksichtigung des venösen RückflussesA RENIN-LIKE ENZYME IN NORMAL HUMAN URINEMECHANISM OF THE INCREASED SENSITIVITY TO RENIN IN NEPHRECTOMIZED ANIMALSDESTRUCTION AND LIBERATION OF ENZYMES IN THE KIDNEY OF NORMAL AND HYPERTENSIVE RABBITS 1 September 1942Volume 17, Issue 3Page: 461-473KeywordsBloodKidneysRabbits ePublished: 1 December 2008 Issue Published: 1 September 1942 PDF downloadLoading ...