tbuckley/cabot-search huggingface dataset:
Abstract 16981: Impact of Economic Recession on PCI Trends
Authors: S. T. A Kaviratne, Mandeep Sidhu, Jeremiah R Brown, John F Robb
Journal: Circulation (2012)

Background: The incidence of myocardial infarctions has steadily declined over the past decade. PCI rates peaked in 2004-2005 and have then declined. Practice and patient related factors have contributed to the decline of PCI. Our purpose is to examine the impact of the economic recession on PCI trends from 2001-2010 for New Hampshire, Maine, and Vermont.  Methods: The PCI were obtained through Dartmouth dynamic registry, which has a catchment area that encompasses New Hampshire, Vermont and Maine. Regional and National unemployment data were obtained through the Department of Labor and Statistic. National and State specific insurance rates were obtained through the US Census data for 2001-2010. State specific cardiovascular prevalence rates were obtained by through individual state specific CDC epidemiology department’s Behavioral Risk Factor Surveillance System (BRFS) questionnaire.  Results: The overall prevalence of cardiovascular disease remained stable in the last 5 years (2005-2010) but remained higher than the national average. The national unemployment rate increased from 4.7% in 2001 to high of 9.6% in 2010 while New Hampshire, Vermont and Maine followed the overall national trends however, had on average 15%-30% less unemployment.  National medical uninsured rate increased from 13.5% in 2001 to a high of 16.3% in 2010, while all three state’s medical uninsured rates stayed relatively stable between 8.8% and 10.8 and did not follow the national trend. DHMC catheterization lab showed steady increase in PCI volume 935 cases in 2001 to high of 1477 in 2005 but steadily declined to 1029 PCIs in 2010. During the same time STEMI cases have steadily increased from 10% to 28% of total volume. During the same time the PCIs due to NSTEMI/UA and stable angina percentage remained between 25%-30% of the total PCI volume but overall numbers declined. The New Hampshire unemployment rate was highly correlated with the STEMI rate (correlation coefficient 0.87, p-value 0.001). However, overall PCI volume trends did not correlate with state specific unemployment.  Conclusions: STEMI cases have increased steadily, while PCI for other indications have declined since peaking in 2005. This trend does not seem to match the overall economic trends in the region.
Abstract 2048: Angiogenesis Protein Therapy With Human Fibroblast Growth Factor (fgf-1): Results Of A Phase I Open Label, Dose Escalation Study In Subjects With CAD Not Eligible For PCI Or CABG
Authors: Lynne E Wagoner, Walter Merrill, Jack Jacobs, Ginger Conway, John Boehmer, Kenneth Thomas, Thomas Stegmann
Journal: Circulation (2007)

Background: Although therapy for CAD has advanced with current therapies, a large number of pts have refractory angina not amenable to revascularization resulting in significant morbidity and morta...
Abstract 14757: Role Of Stat3 Signalling In Aneurysm Development
Authors: Soraya Taleb, Melissa Romain, Bruno Esposito, Marion Dalloz, Aki Yoshimura, Alain Tedgui, ziad mallat
Journal: Circulation (2011)

Autosomal dominant (AD) Hyper-IgE syndrome (HIES) is a rare deficiency arising from mutations in the Signal Transducer and Activator of Transcription 3 (STAT3) gene and characterized by recurrent i...
Abstract 1312: Dietary Supplementation With Sodium Valproate Attenuates Lesion Development In Hyperglycemic Apolipoprotein E-deficient Mice
Authors: Anna J Bowes, Mohammad I Khan, Yuanyuan Shi, Lindsie A Robertson, Geoff H Werstuck
Journal: Circulation (2007)

Diabetes mellitus is a major independent risk factor for cardiovascular disease and stroke however the molecular and cellular mechanisms by which diabetes contributes to the development of vascular disease are not fully understood. We have shown that conditions of hyperglycemia are associated with accumulation of glucosamine, a down stream metabolite of glucose, in specific cell types. Our findings indicate that elevated levels of intracellular glucosamine can promote endoplasmic reticulum (ER) stress in vascular cells leading to inflammation and lipid accumulation - the hallmark features of atherosclerosis. Treatment with valproic acid, a small branch chain fatty acid, can protect cultured cells from glucosamine-induced lipid accumulation by a mechanism that appears to involve inhibition of the signaling factor glycogen synthase kinase (GSK)-3. Here we evaluate the hypothesis that valproic acid can reduce the development and progression of atherosclerotic lesions in a hyperglycemic mouse model of accelerated atherosclerosis. Female apoE −/− mice were made hyperglycemic with multiple low dose injections of streptozotocin. At 15 weeks of age, hyperglycemic mice had accelerated the development of atherosclerotic lesions at the aortic root compared to normoglycemic mice. Mice fed a diet supplemented with 625 mg/kg sodium valproate had significantly reduced lesion volume relative to unsupplemented controls (4.98±0.76 versus 8.62±1.23 μm 3 , P &lt;0.05, n =9). Valproate supplementation had no apparent effect on plasma glucose or plasma lipid levels or on the expression of diagnostic markers of ER stress in the atherosclerotic plaque. Significant reductions were observed in total hepatic lipids (&gt;50.4%, P &lt;0.05, n =3) and hepatic GSK-3β activity (&gt;55.8%, P &lt;0.05, n =3) in mice fed the valproate diet. In conclusion, dietary supplementation with low levels of sodium valproate significantly attenuates atherogenesis in hyperglycemic apoE −/− mice. This effect may involve the previously observed ability of valproate to attenuate the downstream effects of ER stress, such as GSK-3β activity.
Experimental Studies in Metal Cancerigenesis. II. Experimental Uranium Cancers in Rats
Authors: W. C. Hueper, J. H. Zuefle, A. M. Link, M. G. Johnson
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Experimental Studies in Metal Cancerigenesis. II. Experimental Uranium Cancers in Rats Get access W. C. Hueper, M. D., W. C. Hueper, M. D. Cancerigenic Research Laboratory, National Cancer Institute2, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. H. Zuefle, J. H. Zuefle Cancerigenic Research Laboratory, National Cancer Institute2, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar A. M. Link, A. M. Link Cancerigenic Research Laboratory, National Cancer Institute2, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar M. G. Johnson M. G. Johnson Cancerigenic Research Laboratory, National Cancer Institute2, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 2, October 1952, Pages 291–305, https://doi.org/10.1093/jnci/13.2.291 Published: 01 October 1952 Article history Received: 18 January 1952 Published: 01 October 1952
Abstract 17602: Mechanical Dyssynchrony in Non-Compaction Cardiomyopathy: Underlying Mechanism for Improved Response to CRT, Even With Narrow QRS
Authors: Diego Penela, Bart Bijnens, Adelina Doltra, Etelvino Silva, Antonio Berruezo, Lluis Mont, Marta Sitges
Journal: Circulation (2010)

Abnormal myocardial development, such as in noncompaction cardiomyopathy (NCM), may lead also to concomitant abnormal activation and electromechanical coupling due to hypertrabeculation and altered...
Menorrhagia and hypothyroidism
Authors: A. D Weeks
Journal: BMJ (2000)

The sexual health of boys and men Commercial advertisements are needed to create a condom cultureEditor-Yamey highlighted the need for work on the sexual health of boys and men, and he identified education and service provision as the key factors in increasing condom use, among other outcomes. 1Both of these factors fail to address the underlying problem, that condoms are unpopularthey are far short of desired items among young men in particular.A major factor influencing cultural attitudes is not education or services but the media.Global marketing, vast advertising budgets, and sexual imagery are used to sell items as diverse as chocolate bars and sanitary products on television.However, noticeably absent in the United Kingdom is any commercial television advertisement promoting particular condom brands or targeted to the growing market for condoms.Consequently, the promotion of condom use falls largely on public sector bodies.Education and health bodies have already made condoms more available to young people and developed an understanding of their health benefits.However, without a cultural move making condom use popular, such efforts have limited success as health promotion fights to convince people to use unpopular products.Partly as a result, sexually transmitted infections in young people are increasing in England, 2 and there are 90 000 teenage conceptions a year. 3ondoms are produced commercially and lend themselves to many images that are used to market other products successfully, so you would predict a deluge of television adverts promoting one brand above another.Antiquated advertising rules may explain why this has not happened.Those governing condom advertisements on UK television expressly forbid companies from showing the product unwrapped, and consequently the image of an unwrapped condom cannot be normalised or promoted. 4Advertising limitations also dictate social responsibility in advertisements and prohibit anything promoting promiscuity.How far these other measures limit advertisers seems to be unknown, but such restrictions should be measured against the numerous television hours showing promiscuity without any reference to condoms.Furthermore, these considerable restrictions on condom advertising may prevent movement of new producers into markets and consequently stifle the competition necessary to refine marketing and product development.The government is pursuing strategies in communicable disease, sexual health, and HIV, as well as reductions in teenage pregnancy. 3Pragmatic revisions to existing rules on the commercial advertising of condoms may allow commercial interests to work with those of health to alter the image of condoms and increase markets (particularly among young people) in order to help reduce sexually transmitted infections and unwanted pregnancies.
Implications of the 2013 ACC/AHA Cholesterol Guidelines for Adults in Contemporary Cardiovascular Practice
Authors: Thomas M. Maddox, William B. Borden, Fengming Tang, Salim S. Virani, William J. Oetgen, J. Brendan Mullen, Paul S. Chan, Paul N. Casale, Pamela S. Douglas, Fredrick A. Masoudi, Steven A. Farmer, John S. Rumsfeld
Journal: Journal of the American College of Cardiology (2014)
US blood banks to use genetic testing to reduce viral transmission
Authors: Scott Gottlieb
Journal: BMJ (1999)

Blood banks in the United States have begun phasing in new genetic tests designed to help eradicate viral infections that may occur as a result of transfusions.

The new tests can detect small amounts of nucleic acid from several viruses including hepatitis C and HIV. The testing is expected to be used on all donated blood by September. Previously, blood screening has depended largely on detecting antibodies to viruses in …
Abstract 5639: Persistent Depression Predicts Mortality among African Americans with Myocardial Infarction
Authors: Susmita Parashar, Nazeera Dawood, Saadia Khizer, Mary E Kelley, John Spertus, Viola Vaccarino
Journal: Circulation (2008)

Depression predicts adverse outcomes after myocardial infarction (MI), but the relative prognostic importance of new, past or current versus persistent depression among African Americans with MI is unknown. In a prospective MI registry in an inner-city hospital, we measured depressive symptoms in 397 African Americans hospitalized with MI using the Patient Health Questionnaire (PHQ). Patients were categorized as past (received depression treatment prior to MI), new (PHQ&gt;=10 at hospitalization and no past depression), persistent (new plus past depression) or never-depressed. We examined the association between depression categories and 3-yr mortality using multivariable models after adjusting for demographic, clinical, and quality of care variables. There were no differences in sociodemographics, comorbidities and clinical factors among the past (7%), new (23%), persistent (6%) or never-depressed (64%) groups except a younger age in persistent depression group. Patients with persistent depression but not new or past depression had a higher mortality compared with the never-depressed (52% vs. 31%; P=0.02; 36% vs. 31%, P=0.90 and 28% vs. 31%, P=0.7 respectively). Patients with persistent depression were almost three times as likely to die at 3 yrs post-MI (adjusted HR 2.9; 95% CI 1.5, 5.5) as those who were never-depressed (Figure ). Previously treated depression that persists at MI hospitalization, but not new or past depression, strongly predicts post-MI mortality in African Americans. These findings suggest the need to screen MI patients for persistent depression. This research has received full or partial funding support from the American Heart Association, AHA Greater Southeast Affiliate (Alabama, Florida, Georgia, Louisiana, Mississippi, Puerto Rico &amp; Tennessee). Figure 1. Differences in the influence of symptom cluster on event-free survival in HF patients with depressive symptoms
Abstract 20299: Depletion of Extracellular RNA Improves Survival after Myocardial Infarction Reducing Vascular Permeability, Edema Formation and Myocardial Tissue Damage
Authors: Philipp Stieger, Christiane Thoelen, Mathias Grebe, Jan-Marcus Daniel, Klaus T Preissner, Silvia Fischer, Langheinrich Alexander, Harald Tillmanns, Daniel G Sedding
Journal: Circulation (2010)

Cell injury following myocardial infarction (MI) leads to the exposure of intracellular material and is associated with increased permeability of vessels in the vicinity of the damage. This process...
Abstract 11044: Elevated Heart Rate Two Weeks after Onset, Despite Successful Reperfusion Therapy, Indicates Poor Prognosis in Patients with a First ST-Elevation Acute Myocardial Infarction
Authors: Noriaki Iwahashi, Masami Kosuge, Mitsuaki Endo, Nobuhiko Maejima, Kengo Tsukahara, Yoshio Tahara, Kiyoshi Hibi, Toshiaki Ebina, Shinichi Sumita, Toshiyuki Ishikawa, Kazuaki Uchino, Satoshi Umemura, Kazuo Kimura
Journal: Circulation (2011)
Biopsychobehavioral correlates of insomnia. IV: Diagnosis based on DSM- III
Authors: Tjiauw-ling Tan, Joyce D. Kales, Anthony Kales, constantin R. Soldatos, Edward O. Bixler
Journal: American Journal of Psychiatry (1984)

DSM-III diagnoses were established for 100 patients with chronic insomnia. Principal and additional diagnoses on axis I and II (psychiatric and personality disorders) were extremely prevalent. Only five patients had a principal diagnosis on axis III (physical disorders). The most common diagnoses on axis I were dysthymic, anxiety, somatoform, and substance use disorders. Compulsive personality disorder or trait was the most common axis II diagnosis. Ninety-five patients had multiple diagnoses. This study confirms that patients with chronic insomnia have a high prevalence of psychopathology and characteristic internalizing patterns of anxiety, depression, obsessive-compulsiveness, phobia, and excessive somatic concerns.
Abstract 2506: Long-Term Effect of Robotic-Assisted Left Ventricular Epicardial Leads for Cardiac Resynchronization Therapy on Mortality
Authors: Andrew D Choi, Olga Kristof-Kuteyeva, Wallacy Garcia, Joseph J DeRose, Sandhya Balaram, Jonathan S Steinberg
Journal: Circulation (2007)

INTRODUCTION: In cardiac resynchronization therapy (CRT), our group has previously reported on positive clinical response and reverse remodeling using a novel robotically assisted left ventricular (LV) epicardial lead placement approach for pts with primary lead implant failure. In addition, CRT via transvenous approach is associated with an approximate 20% mortality rate at 18 mos. Long term mortality via robotic placement is unknown. METHODS: We evaluated 71 pts (70 ± 11 yrs, 48 [68%] male) who underwent robotic LV lead placement after failed transvenous LV lead placement. Leads were placed based on Tissue Doppler Imaging to localize the site of latest mechanical activation. The Social Security Death Index was queried to identify mortality. RESULTS: All pts had successful lead placement and were discharged in stable condition. During a follow-up (f/u) of 27 ± 16 mos, there were 18 deaths (25%) after 17.3 ± 14.5 mos (range 1.3 – 50.2 mos) (Figure ). These pts were older (77 ± 6 v. 68 ± 11 yrs; p &lt; 0.001), with a lower EF (13 ± 7% v. 18 ± 9%; p &lt; 0.05) and carried a greater symptom burden by NYHA class (3.6 ± 0.5 v. 3.1 ± 0.5; p = 0.02) when compared to those alive. There was no difference in pts with respect to HF duration, cardiomyopathy etiology or atrial fibrillation prevalence. A significant improvement in symptoms by NYHA class (3.1 ± 0.5 to 2.3 ± 0.7; p &lt; 0.001) was seen at 8 ± 3 mos. CONCLUSION: Pts undergoing robotic LV lead implant show symptomatic improvement, and have a similar mortality rate to transvenous placement during f/u. Those at greatest risk for death include older pts with a very low EF; risk/benefit for these pts should be carefully considered before undergoing implant.
Abortions increased by nearly 8% in Norway
Authors: O.-E. Iversen, S. T. Nilsen
Journal: BMJ (1996)

EDITOR,—The number of women using oral contraceptives in Norway has steadily increased from about 140 000 in 1985 to 160 000 in 1994 (roughly 17% of fertile women). The recent reports of an increased risk of venous thromboembolism associated with third generation compared with second generation oral contraceptives received much attention in the media, and members of the Norwegian parliament demanded that health authorities should take action against the only third generation pill in Norway that contained desogestrel. Last November the Norwegian Medicines …
Long-term hospital treatment of borderline patients: a descriptive outcome study
Authors: L Tucker, S F Bauer, S Wagner, D Harlam, I Sher
Journal: American Journal of Psychiatry (1987)

The authors report a prospective 2-year outcome study of 40 inpatients with severe personality disorders who were treated on a specialized long-term unit for patients with "borderline conditions." Treatment goals included improving interpersonal relationships and facilitating a lasting discharge from the hospital. Data were collected at admission, discharge, and 1 and 2 years after discharge. The data reflect change from admission to follow-up in impulsivity, psychotherapy, and social adjustment. Mediating effects of length of stay on outcome are discussed.
Abstract 18349: Cigarette Smoking Associated With Increased All-Cause Mortality In Individuals Across the Whole Spectrum of Coronary Atherosclerosis
Authors: John W McEvoy, Michael J Blaha, Juan J Rivera, Atif N Khan, Leslee S Shaw, Daniel S Berman, Raggi P, James K Min, Tracy Q Callister, John A Rumberger, Matthew J Budoff, Roger S Blumentha, Khurram Nasir
Journal: Circulation (2010)

Background:  Data is limited on the prognostic impact of smoking on atherosclerotic imaging burden.The purpose of this study was to assess whether smoking remains an independent predictor of all cause mortality in the absence of, as well as across increasing, coronary artery calcium (CAC) burden in a long term follow—up.   Methods:  The study cohort consisted of 44,052 (54±11 years, 54% males) asymptomatic individuals free of known coronary heart disease referred for electron beam computed tomography (EBT) for the assessment of subclinical atherosclerosis. Patients were followed for a mean of 5.6 (range 1–13 years). The primary endpoint for the study cohort was mortality from any cause.   Results:  14% (n=6020) of subjects were smokers. There were 901 deaths (2.05%) overall, with significantly lower (p  400 was noted in 37% participants at baseline as compared to 13% of smokers who survived (p 400 with smoking were 3.82 (2.82–5.22), 3.54 (2.57–4.89), and 2.71 (2.12–3.48).   Conclusion:  A higher CAC score contributed significantly to predicting all cause mortality among smokers. Individuals with CAC=0 who smoke are at relatively increased risk of death.. Efforts should be made to encourage smoking cessation in those with and without CAC=0.
Making a diagnosis
Authors: A. Taylor
Journal: BMJ (2003)

Couples present at a surgery or clinic because they have not conceived as quickly as they had expected. Some are concerned there may be serious problem that will stop them having a family. Subfertility investigations determine whether a problem exists and enable a rational discussion about options for treatment. The treatment may include waiting for a spontaneous conception. Some of the distress associated with subfertility may be reduced by a prompt and systematic protocol of investigations that allows couples to move quickly to the most appropriate treatment.

Subfertility is defined as failure to conceive after one year of unprotected regular sexual intercourse. Although usually it would be reasonable to start investigations after this time, earlier investigations and referral may be justified where there are important factors in either partner's history.,

View this table:

Factors that may warrant early referral or investigation*



A woman's age is one of the main factors affecting her chance of conception. The chances of most treatments being successful are reduced substantially after a woman reaches 35 years and become negligible by her mid-40s. Hence, if couples are to gain the maximum benefit from the most appropriate treatment, investigations should be started promptly (after six months of trying if the woman is over 35) and completed according to a locally agreed protocol between general practitioners and hospital providers. Couples can then be counselled about the implications of test results, and a management plan agreed that takes into account the test results and the couple's beliefs and wishes.

At initial presentation both partners should have a history taken and be examined. Regular intercourse two to three times a week should be advised, but basal body temperature charts are not helpful and should be avoided.

The female partner of couples presenting with subfertility should have their rubella status checked …
Altered wound healing in mice lacking a functional osteopontin gene (spp1).
Authors: E Kim, C M Cham, M M Véniant, P Ambroziak, S G Young
Journal: Journal of Clinical Investigation (1998)

Familial hypobetalipoproteinemia (FHbeta), a syndrome characterized by low plasma cholesterol levels, is caused by mutations in the apo-B gene that interfere with the synthesis of apo-B100. FHbeta mutations frequently lead to the synthesis of a truncated form of apo-B, which typically is present in plasma at < 5% of the levels of apo-B100. Although many FHbeta mutations have been characterized, the basic mechanisms causing the low plasma levels of truncated apo-B variants have not been defined. We used gene targeting to create a mutant allele that exclusively yields a truncated apo-B, apo-B83. In mice heterozygous for the Apob83 allele, plasma levels and the size and density distribution of apo-B83-containing lipoproteins were strikingly similar to those observed in humans with FHbeta and an apo-B83 mutation. Analysis of mice carrying the Apob83 mutation revealed two mechanisms for the low plasma levels of apo-B83. First, Apob83 mRNA levels and apo-B83 secretion were reduced 76 and 72%, respectively. Second, apo-B83 was removed rapidly from the plasma, compared with apo-B100. This mouse model provides a new level of understanding of FHbeta and adds new insights into apo-B metabolism.