tbuckley/cabot-search huggingface dataset:
Abstract 2321: Reactive Oxygen Species-Induced Activation of 5′AMP-Activated Protein Kinase Mediates Cardioprotection Against Ischemia and Reperfusion Injury
Authors: Geert Onderwater, Nazha Hamdani, M. Jumoke A Vreden, Jeroen Steenhuisen, Etto C Eringa, Ger J Stienen, Stephan A Loer, R. Arthur Bouwman, Regis R Lamberts
Journal: Circulation (2008)

The myocardium possesses intrinsic protective mechanisms against ischemia and reperfusion injury (I/R). 5′AMP-activated protein kinase (AMPK) is known as regulator of cellular energy status and is reduced during diabetes mellitus. Recently, AMPK is also implicated in ischemic preconditioning leading to cardioprotection against I/R. We hypothesize that AMPK is involved in anesthetic-induced cardioprotection and that this AMPK activation is evoked by production of reactive oxygen species (ROS). Isolated Langendorff-perfused rat hearts were subjected to 35 minutes of global ischemia followed by 120 minutes of reperfusion. Hearts were divided into 2 groups: a Control group and a Sevo group receiving three times 5-minute episodes of 2.5 vol% sevoflurane before I/R. AMPK phosphorylation was determined with Western Blot analysis. Cardioprotection was assessed as recovery of left ventricular pressure after I/R and as infarct size using triphenyltetrazolium chloride staining. In the Control group, I/R resulted in a twofold increase in phosphorylation levels of AMPK (Control 1.0 ± 0.1 vs. Control-I/R: 2.3 ± 0.1 a.u., n = 4, p &lt; 0.05). Sevoflurane preconditioning did not immediately, prior to ischemia, affect the AMPK phosphorylation (Sevo 0.9 ± 0.2 vs. Control 1.0 ± 0.2, n = 6), but doubled the increase in AMPK phosphorylation to control after ischemia (Sevo-I: 2.0 ± 0.5 (vs. Control-I), n = 6, p &lt; 0.05), as well as after I/R (Sevo-I/R: 2.1 ± 0.3 vs. (Control-I/R), n = 6, p &lt; 0.05). The AMPK-inhibitor compound C (1 and 10 μM) reduced the increase in AMPK phosphorylation and abolished the cardioprotection derived from functional recovery and infarct size. In addition, the ROS-scavenger n-(2-mercaptopropionyl)-glycine (MPG, 1mM) also reduced the sevoflurane-mediated increase in AMPK phosphorylation and completely prevented cardioprotection. These results demonstrate for the first time a direct link between AMPK activation and the production of ROS in cardioprotection. We conclude that anesthetic-induced AMPK activation protects the heart against I/R and relies on production of ROS, which might be especially important in the context of impaired cardioprotection in the diabetic myocardium.
The case of Anna O.: a reformulation
Authors: M H Hollender
Journal: American Journal of Psychiatry (1980)

The best known of all psychotherapy patients. Anna O., entered treatment with Josef Breuer in December 1880. Modern psychotherapy begins with that encounter. Information gathered in the intervening years places us in a favorable position to review and reformulate the case. To do so may have practical and theoretical, as well as historical, importance.
Social networks and mental health: on overview
Authors: Milton Greenblatt, Rosina M. Becerra, E. A. Serafetinides
Journal: American Journal of Psychiatry (1982)

Research has shown that social networks can act as social support systems to promote mental health and buffer psychological stress. In this selective review the authors illuminate patterns and characteristics of social networks that maintain health and help prevent illness, explore the relationship between social networks and the course and outcome of treatment for mental illness, and describe clinical network interventions that have been used to facilitate inpatient care and maximize performance of ex-patients in the community. The authors also discuss the implications of research findings for mental health practice.
Screening for Prostate Cancer
Authors: Anthony V D'Amico, Matthew R Smith
Journal: New England Journal of Medicine (2012)

This interactive feature addresses the diagnosis or management of a clinical case.A case vignette is followed by specific clinical options, neither of which can be considered either correct or incorrect.In short essays, experts in the field then argue for each of the options.Readers can participate in forming community opinion by choosing one of the options and, if they like, providing their reasons. Case VignetteA 55-year-old man presents to the primary care clinic for a routine health maintenance examination.He has hypertension, for which he takes a thiazide diuretic, and diabetes, which is well controlled with metformin therapy.He has no known allergies to medications.He does not smoke, and he drinks two to three beers each week.He works as an accountant and stays active by going to the gym five times a week.His blood pressure at this visit is 130/66 mm Hg.His glycated hemoglobin level, as measured recently, was 6.3%.His bodymass index (the weight in kilograms divided by the square of the height in meters) is 28.He has no symptoms of urinary frequency or difficulty voiding.He has never undergone prostate-specific antigen (PSA) testing, and at his most recent digital rectal examination, which was performed 5 years ago, no abnormalities were detected.He reports that one of his uncles recently received a diagnosis of prostate cancer at 75 years of age, and he is concerned that the disease might develop in him also.He admits that he is confused by conflicting reports he has read in the newspaper about whether prostate screening is actually beneficial.He asks whether he should be screened with a digital rectal examination and a PSA test.Which one of the following approaches would you find appropriate for this patient?Base your choice on the published literature, your own experience, recent guidelines, and other sources of information, as appropriate.1. Recommend PSA screening. Recommend against PSA screening.To aid in your decision making, each of these approaches is defended in the following short essays by an expert in the field of prostate cancer.Given your knowledge of the patient and the points made by the experts, which approach would you choose? Option 1Recommend PSA Screening
Isolated Carpal Bone Metastases from Bronchogenic Cancer Evident on Bone Scintigraphy
Authors: MELTEM CAGLAR, EMEL CEYLAN
Journal: Clinical Nuclear Medicine (2001)

From Hacettepe University Medical Faculty Department of Nuclear Medicine, Ankara, Turkey Received for publication June 12, 2000. Accepted July 31, 2000. Reprint requests: Meltem Caglar, M.D., Hacettepe University, Medical Faculty, Department of Nuclear Medicine, Sıhhıye Ankara, 06100 Turkey. E-mail: [email protected]
GASTROSCOPIC OBSERVATIONS OF SYPHILIS OF THE STOMACH
Authors: J. B. Carey, R. S. Ylvisaker
Journal: Annals of Internal Medicine (1938)

Case Reports1 October 1938GASTROSCOPIC OBSERVATIONS OF SYPHILIS OF THE STOMACHJ. B. CAREY, M.D., F.A.C.P., R. S. YLVISAKER, M.D., F.A.C.P.J. B. CAREY, M.D., F.A.C.P.Search for more papers by this author, R. S. YLVISAKER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-4-544 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEnglish medical literature contains no gastroscopic description of syphilis of the stomach of thelinitis plasticaor leather bottle type. Schindler's1English text mentions cases seen with Moutier and referred to in the latter's French text, and in addition describes two syphilitic stomachs of contracted hour-glass type, both of which had been treated (one operated upon) and which showed only healed scars at time of gastroscopy. Renshaw,2in discussing the differential diagnosis of tumors of the stomach, refers to syphilis of the stomach as having "no constant characteristics." "There have been tumors with and without ulcers. The positive blood serum...References1. SCHINDLER R: Gastroscopy, Chicago University Press, 1937. Google Scholar2. RENSHAW JF: Lymphoblastoma of the stomach, Jr. Am. Med. Assoc., 1936, cvii, 426. CrossrefGoogle Scholar3. KERKHOF A: Gastroscopy, Minn. Med., 1937, xix, 647. Google Scholar4. HENNING N: Textbook of gastroscopy, Oxford University Press, 1937. Google Scholar5. SWALMJACKSONMORRISON WACLL: Correlation of clinical and gastroscopic findings in chronic gastritis, Rev. Gastroenterol., 1936, iii, 9. Google Scholar6. GUTZEITTEITGE : Gastroskopie, Urban and Schwarzenberg, Berlin and Wien, 1937. Google Scholar7. MOUTIER F: Gastroscopie, Masson et Cie, Paris, 1935. Google Scholar8. MOUTIERGIRAULTSEBRAY FAC: Pseudo-cancers gastriques d'origine syphilitique, Arch. d. Mal. d l'app. Digest., 1937, xxvii, 637. Google Scholar9. MOUTIER F: Pseudo-cancers gastriques peut-etre syphilitiques, Arch. d. Mal. d l'app. Digest., 1937, xxvii, 653. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Read at the meeting of the Minnesota Society of Internal Medicine, at Duluth, Minnesota, June 4, 1938.From the Gastroscopy Clinic, The Medical School, University of Minnesota, University Hospital Dispensary. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPathologische Anatomie der SyphilisDie Krankheiten des MagensGastroscopic observations in chronic gastritis 1 October 1938Volume 12, Issue 4Page: 544-550KeywordsBloodGastroenterology and hepatologyScarsStomachSyphilisUlcers ePublished: 1 December 2008 Issue Published: 1 October 1938 PDF downloadLoading ...
Abstract 987: Incidence, Predictors and Clinical Impact of Bleeding after Transradial Coronary Stenting and Maximal Antiplatelet Therapy
Authors: Olivier F Bertrand, Eric Larose, Josep Rodes-Cabau, Onil Gleeton, Isabelle Taillon, Louis Roy, Paul Poirier, Olivier Costerousse, Robert De Larochelliere
Journal: Circulation (2008)
Two different coronary blood flow velocity patterns in thrombolysis in myocardial infarction flow grade 2 in acute myocardial infarction
Authors: Koichi Yamamoto, Hiroshi Ito, Katsuomi Iwakura, Shigeo Kawano, Masashi Ikushima, Tohru Masuyama, Toshio Ogihara, Kenshi Fujii
Journal: Journal of the American College of Cardiology (2002)
Abstract 101: Ventricular Fibrillation Frequency Characteristics are Altered in Acute Myocardial Infarction
Authors: Julia Indik, Richard L Donnerstein, Robert A Berg, Ronald W Hilwig, Marc D Berg, Karl B Kern
Journal: Circulation (2006)

Background: For brief duration ventricular fibrillation (VF), optimal therapy is prompt defibrillation. For prolonged VF, survival is improved by providing chest compressions prior to the first defibrillatory shock. Future automated external defibrillators (AEDs) are being designed to direct rescue efforts by inferring the duration of VF based on its waveform characteristics such as frequency content. This approach assumes that the VF waveform is an appropriate surrogate for VF duration and is not affected by structural heart disease. We hypothesized that an acute myocardial infarction (MI) may alter the frequency content of ventricular fibrillation (VF). Methods: VF was induced in 11 swine with an acute MI after occlusion of the mid-left anterior descending coronary artery and in 16 control swine. VF waveforms were analyzed for mean, median, and dominant frequency, as well as bandwidth, defined as the frequency interval containing 50% of the total power about the median. Results: All frequency characteri...
Early Diagnosis of Gastric Carcinoma
Authors: James M. Anders
Journal: Annals of Internal Medicine (1927)

Article1 September 1927Early Diagnosis of Gastric CarcinomaJAMES M. ANDERS, M.D.JAMES M. ANDERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-3-137 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe seat of a large percentage of carcinomata is the stomach. For example, Reiche's Hamburg statistics show that 50.2 percent, of all cancers are gastric (1). The limits of this paper will not permit of a full discussion of the nature of carcinoma. It may be pointed out that the hypothesis of Dr. Guy and Mr. Barnard (2) that cancer is due to an ultra-microscopic, extrinsic virus, requires further confirmation before it can be accepted, since "it has not yet been possible to produce the disease with artificial culture of it." The researches of these investigators, however, aroused intense interest...Bibliography(1) OSLERMCCRAE : Modern Medicine, Vol. iii, p. 199. Google Scholar(2) THE LANCET, 1925, Vol. ccix, Vol ii, p. 110-117. Google Scholar(3) THE LANCET, 1925. Vol. cc, 109, Vol. ii, p. 1007. Google Scholar(3) AMERICAN JOURNAL OF THE MEDICAL SCIENCES, Oct., 1925, p. 481. Google Scholar(5) BLOODGOOD : Boston Med. Jour., 1923, clxxxviii, p. 227. Google Scholar(6) MAYO WJ Collected Papers of Mayo Clinic, 1914, vi, p. 674. Google Scholar(7) COMPTES RENDUS DE LA SOCIETE DE BIOLOGIE, Paris, 1924, lxli, p. 1183-1924. Google Scholar(8) CANCER―Vol ii, p. 57-8. Google Scholar(9) ANDERSBOSTON : Medical Diagnosis, p. 511. Google Scholar(10) THE LANCET, 1925. Vl. ccix, Vl. ii, p. 379. Google Scholar(11) JOURNAL AMERICAN MEDICAL ASSOCIATION, June 21, 1924. Google Scholar(12) AMERICAN JOURNAL ROENTGENOL, January, 1925. Google Scholar(13) TUMORI, Rome, 1925, ii: p. 318. Google Scholar(14) THE LANCET, 1925, Vl. ccix, Vl. ii, p. 379. Google Scholar(15) "THE PRACTICAL VALUE OF NEWSPAPER PUBLICITY IN THE CONTROL OF CANCER." Jour. Amer. Med. Assoc. 1926, p. 347-349. Google Scholar(16) PALMER , The "Acid Test" in Gastric and Duodenal Ulcer, Jour. Amer. Med. Ass'n, 1927, lxxxviii, p. 1779. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia., Pa.*Read before the Newcastle Medical Society. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1927Volume 1, Issue 3Page: 137-144KeywordsGastric cancerStomach ePublished: 1 December 2008 Issue Published: 1 September 1927 PDF downloadLoading ...
Evaluation of Intra-Articular Thio-Tepa in Rheumatoid Arthritis
Authors: J. Zuckner, J. Uddin, R. H. Ramsey, G. E. Gantner, A. M. Ahern, R. W. Dorner
Journal: Annals of the Rheumatic Diseases (1966)

The potential action of cytotoxic agents such as alkylating drugs and antimetabolites on the immune response and inflammatory process has suggested their trial in the treatment of rheumatic diseases. Nitrogen mustard was tried initially both by intravenous and intra-articular injection in the therapy of rheumatoid arthritis and gave variable responses (Jimenez Diaz, 1951; Jimenez Diaz, Lopez Garcia, Merchante, and Perianes, 1951; Shutkin, 1951; Phillips, Phillips, and Caraway, 1952; Cohen, Rose, and Cooper, 1953; Scherbel, 1957; Scherbel, Schuchter, and Weyman, 1957; Scherbel, Mackenzie, and Atdjian, 1963). Scherbel and others (1957) noted a rapid and prolonged decrease in joint swelling after the intra-articular injection of nitrogen mustard in patients with rheumatoid arthritis, but not a corresponding satisfactory relief of pain. He, therefore, combined steroids with nitrogen mustard for intra-articular injection and obtained more beneficial results. When a purine antagonist, 6-mercaptopurine, was administered to patients with systemic lupus erythematosus the responses were equivocal (Lee, Meiselas, Zingale, and Richman (1961). The development of adjuvant-induced arthritis in rats has been successfully inhibited by 6-mercaptopurine (Kalliomaki, Saarimaa, and Toivanen, 1964). Methotrexate has been used experimentally in psoriatic arthritis (O'Brien, Van Scott, Black, Eisen, and Bunim, 1962; Black, O'Brien, Van Scott, Auerbach, Eisen, and Bunim, 1964). Recently, thio-tepa (N, N', N2 triethylenethiophosphoramide) has been reported to give satisfactory improvement after intra-articular administration to patients with rheumatoid arthritis (Flatt, 1962; Gross, 1963; Pace, Kantor, and McEwen, 1964). Some of the latter results are difficult to interpret because thio-tepa was, in many instances, combined with steroids or local anaesthetics for intra-articular injection. Rheumatoid arthritis is a disease in which rheumatoid factor(s), an abnormal antibody(s) or antibody-like substance(s), is frequently present. Alkylating agents interfere with antibody production and, therefore, could inhibit the possible immune reaction and inflammatory changes characteristic of rheumatoid arthritis. It seemed appropriate to study this possibility in more detail. Thio-tepa, an alkylating agent, was selected for study because it can be placed in solution at a pH which is not irritating to the tissues and, consequently, can be given by all parenteral routes. The present investigation describes our results after intra-articular injection of thio-tepa into the knee joint of nineteen patients with rheumatoid arthritis.
Rethinking our approach to postpartum haemorrhage and uterotonics
Authors: Andrew D Weeks, James P Neilson
Journal: BMJ (2015)

<b>Andrew Weeks</b> and <b>James Neilson</b> suggest that we have inappropriately generalised evidence on the use of uterotonics from uncomplicated births to all births. They call for stronger focus on women with complex births to reduce deaths from postpartum haemorrhage
First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011
Authors: M Unemo, D Golparian, A Stary, A Eigentler
Journal: Eurosurveillance (2011)

We describe the first cefixime-resistant Neisseria gonorrhoeae strain in Austria that caused treatment failure.It follows the first five cases in Europe of cefixime treatment failure, reported in Norway in 2010 and the United Kingdom in 2011. Effective treatment of gonorrhoea is crucial for public health control and, at present, requires substantially enhanced awareness, more frequent test-of-cure, interaction with experts after therapeutic failure, tracing and therapy of contacts, and surveillance of gonococcal antimicrobial resistance and treatment failures worldwide.
Abstract PL-1: Genome-Directed Therapeutics for Endocrine Therapy Resistant ER+ Breast Cancer
Authors: Matthew J. Ellis
Journal: Cancer Research (2015)

Abstract As a result of improvements in DNA and RNA sequencing techniques the genomic structure of estrogen receptor positive breast cancer is increasingly well documented, but extracting clinically actionable information from these complex data sets has proved fraught with difficulties. Barriers to progress include the lack of pharmacological hypotheses for novel luminal breast cancer tumor suppressor genes (e.g. MAP3K1, MLL3, SF3B1); 2) a lack of a full understanding of interactions between mutation status, the prognosis of ER+ breast cancer, and the effectiveness of endocrine therapy; 3) an inadequate collection of patient-derived xenograft (PDX) models for luminal breast cancer that fully encompass the heterogeneity of the disease; 4) the logistical barriers of developing adjuvant strategies to exploit rare drivers present in less than 5% of tumor samples; 5) insufficient genomic discovery efforts directed towards samples accrued from patients suffering from endocrine therapy resistant disease progression and 6) an incomplete understanding of how complex somatic genotypes drive the biochemical events responsible for the “hallmarks” of luminal cancer. To better address these issues, five areas of investigation will be discussed: 1) somatic mutation diagnosis in DNA from primary breast cancer samples from patients treated with adjuvant tamoxifen and followed for over 20 years; 2) DNA and RNA sequencing of samples accrued from patients treated with neoadjuvant endocrine therapy to define the molecular origins of intrinsic aromatase inhibitor resistance and to identify pharmacological hypothesis; 3) efforts to expand and catalog patient-derived xenografts from ER+ breast cancers, including the use of mass spectrometry-based analysis of their proteomes and phosphoproteomes to expand our knowledge of the biochemistry of individual tumors; 4) a functional and pharmacological investigation of mutations in ESR1, including resistance-activating chromosomal translocations, and 5) the development of a neoadjuvant endocrine therapy strategy that identifies patients with intrinsic endocrine therapy resistance within a month of starting treatment so that they can be triaged to mutation-matched investigational treatment. Citation Format: Matthew J. Ellis. Genome-Directed Therapeutics for Endocrine Therapy Resistant ER+ Breast Cancer [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr PL-1.
Prediction Of Therapeutic Resistance In Adult Acute Myeloid Leukemia: Analysis Of 4,550 Newly Diagnosed Patients From MRC/NCRI, HOVON/SAKK, SWOG, and MD Anderson Cancer Center
Authors: Roland B Walter, Megan Othus, Alan K. Burnett, Bob Löwenberg, Hagop M. Kantarjian, Gert J. Ossenkoppele, Robert K. Hills, Farhad Ravandi, Anna Evans, Sherry R. Pierce, Frederick R. Appelbaum, Elihu H. Estey
Journal: Blood (2013)
Marijuana effects on simulated flying ability
Authors: D S Janowsky, M P Meacham, J D Blaine, M Schoor, L P Bozzetti
Journal: American Journal of Psychiatry (1976)

The authors studied the effects of marijuana intoxication on the ability of 10 certified airplane pilots to operate a flight simulator. They used a randomized double-blind crossover design to compare the effect of active versus placebo marijuana. They found that all 10 pilots showed a significant decrease in measurements of flying performance 30 minutes after smoking active marijuana. For a group of 6 pilots tested sequentially for 6 hours, a nonsignificant decrease in flying performance continued for 2 hours after smoking the active drug. The authors conclude that the effects of marijuana on flying performance may represent a sensitive indicator of the drug's psychomotor effects.