tbuckley/cabot-search huggingface dataset:
FRI-533 Anti-MFAP-5 siRNA loaded polycarbonate nanohydrogels for antistromal therapy in hepatocellular carcinoma
Authors: Paul Schneider, Alexander Fuchs, Lutz Nuhn, Barbara Schroers, Mustafa Diken, Twan Lammers, Stephan Grabbe, Jörn M. Schattenberg, Leonard Kaps
Journal: Journal of Hepatology (2024)
FRI-539 EGF/STAT1 signals to maintain ECM1 expression in hepatic homeostasis are disrupted by IFNγ/NRF2 in chronic liver disease
Authors: Yujia Li, Frederik Link, Weiguo Fan, Rilu Feng, Seddik Hammad, Honglei Weng, Matthias Ebert, Steven Dooley, Sai Wang
Journal: Journal of Hepatology (2024)
FRI-070-YI Prevalence of dysgeusia in patients with advanced chronic liver disease, relationship with the liver-disease progression status, and impact on malnutrition-sarcopenia-frailty
Authors: Marcello Dallio, Mario Romeo, Marina Cipullo, Annachiara Coppola, Simone Mammone, Giuseppe Zagaria, Giorgia Iadanza, Carmine Napolitano, Simone Olivieri, Luigi Maria Vitale, Alessandro Federico
Journal: Journal of Hepatology (2024)
FRI-231 Compared to complete abstainers, non-significant alcohol use may be associated with more severe liver disease in patients with metabolic dysfunction-associated steatotic liver disease (MASLD)-The multicentre study of the indian consortium on MASLD
Authors: Ajay Kumar Duseja, Manu Mehta, Arka De, Shivaram Prasad Singh, Shrikant Mukewar, Saurabh Mukewar, Shalimar Shalimar, Omesh Goyal, Jayanthi Venkataraman, VK Dixit, Krishnadas Devadas, Varun Mehta, Piyush Ranjan, Anil Arora, Abha Nagral, Narendra S. Choudhary, Sanjib Kar, Brij Sharma, Sandeep Nijhawan, Dibyalochan Praharaj, Aakash Shukla, Nagaraja Rao Padaki, Arun Valsan, Sanjeev Saigal, K Narayanaswamy, Rajiv Mehta, Pankaj Asati, Sunil Dadhich, Prasad V G Mohan, Mukul Rastogi, Abraham Koshy, Mallika Bhattacharya, Rohit Gupta, Akash Roy, Rakhi Maiwall, J Sanyal Arun
Journal: Journal of Hepatology (2024)
FRI-233 Cardiovascular disease burden in patients with and without metabolic dysfunction-associated steatohepatitis: data from the unCoVer-MASH longitudinal cohort study
Authors: Elisabetta Bugianesi, Anurag Mehta, Kamal Kant Mangla, Abhishek Shankar Chandramouli, Katrine Grau, Niels Krarup, Ahsan Shoeb Patel
Journal: Journal of Hepatology (2024)
OS-119 Survodutide (BI 456906), a glucagon receptor/glucagon-like peptide-1 receptor (GCGR/GLP-1R) dual agonist, in people with compensated and decompensated cirrhosis: a multinational, open-label, phase 1 trial
Authors: Eric Lawitz, Mandy Fraessdorf, Guy Neff, Jörn M Schattenberg, Mazen Noureddin, Naim Alkhouri, Bernhard Schmid, Charles P. Andrews, István Takács, Samina Ajaz Hussain, Wiebke K. Fenske, Edward J. Gane, Azadeh Hosseini-Tabatabaei, Arun J Sanyal, Daniel Mazo, Ramy Younes
Journal: Journal of Hepatology (2024)
Real-world evidence for factors associated with maintenance treatment practices among U.S. adults with autoimmune hepatitis
Authors: Therese Bittermann, Lina Yagan, Ranganath G. Kathawate, Ethan M. Weinberg, Eliot G. Peyster, James D. Lewis, Cynthia Levy, David S. Goldberg
Journal: Hepatology (2024)

Background and Aims: While avoidance of long-term corticosteroids is a common objective in the management of autoimmune hepatitis (AIH), prolonged immunosuppression is usually required to prevent disease progression. This study investigates the patient and provider factors associated with treatment patterns in US patients with AIH. Approach and Results: A retrospective cohort of adults with the incident and prevalent AIH was identified from Optum’s deidentified Clinformatics Data Mart Database. All patients were followed for at least 2 years, with exposures assessed during the first year and treatment patterns during the second. Patient and provider factors associated with corticosteroid-sparing monotherapy and cumulative prednisone use were identified using multivariable logistic and linear regression, respectively. The cohort was 81.2% female, 66.3% White, 11.3% Black, 11.2% Hispanic, and with a median age of 61 years. Among 2203 patients with ≥1 AIH prescription fill, 83.1% received a single regimen for &gt;6 months of the observation year, which included 52.2% azathioprine monotherapy, 16.9% azathioprine/prednisone, and 13.3% prednisone monotherapy. Budesonide use was uncommon (2.1% combination and 1.9% monotherapy). Hispanic ethnicity (aOR: 0.56; p = 0.006), cirrhosis (aOR: 0.73; p = 0.019), osteoporosis (aOR: 0.54; p =0.001), and top quintile of provider AIH experience (aOR: 0.66; p = 0.005) were independently associated with lower use of corticosteroid-sparing monotherapy. Cumulative prednisone use was greater with diabetes (+441 mg/y; p = 0.004), osteoporosis (+749 mg/y; p &lt; 0.001), and highly experienced providers (+556 mg/y; p &lt; 0.001). Conclusions: Long-term prednisone therapy remains common and unexpectedly higher among patients with comorbidities potentially aggravated by corticosteroids. The greater use of corticosteroid-based therapy with highly experienced providers may reflect more treatment-refractory disease.
FRI-053 Wide variations in proton pump inhibitor use in hospitalized patients with cirrhosis in a worldwide cohort shows little impact on clinically significant outcomes
Authors: Jasmohan Bajaj, Patrick S. Kamath, Qing Xie, Mark Topazian, Peter Hayes, Aldo Torre, Hailemichael Desalegn, Ramazan Idilman, Zhujun Cao, Mario Alvares-da-Silva, Jacob George, Florence Wong, Brian Bush, Wai-Kay Seto, Leroy Thacker, Shiv Kumar Sarin, Alexandra Alexopoulou, Samagra Agarwal, R. Bart Takkenberg, Abha Nagral, Mithun Sharma, Bin Xu, Libo Yan, Mauricio Castillo, Marie Jeanne Lohoues, Tongluk Teerasarntipan, Danielle Ho Wei Ling, Zheng Xin, Kara Wegermann, Zeki Karasu, Damien Leith, Maria Mercedes Rodriguez Gazari, Alberto Farias, Federico Vilamil, Lívia Victor, Adrian Gadano, Lilian Torres Made, Godolfino Miranda Zazueta, Alexander Prudence, Edith Okeke, Scott Davison, Mussagy Tarmamade, Andrew Keaveny, Haibing Gao, Somya Sheshadri, Belimi Hibat Allah, Jinjun Chen, Dalia Allam, Aloysious Aravinthan, Carlos Benitez, Neil Rajoriya, Danielle Adebayo, Cameron Gofton, Hooi Ling Si, Surendra Kumar, Fuchen Dong, Peng Hu, Chenghai Liu, Liou Wei Lun, Henok Fisseha, Anil Arora, Yanhang Gao, Chuanwu Zhu, Minghua Su, Mingqin Lu, Wei Wang, Feng Peng, Ruveena Bhavani, Jin Guan, Xiaozhong Wang, Suditi Rahematpura, Nik Ma Nik Arsyad, Somaya Albhaisi, Chinmay Bera, Ning-Ping Zhang, Akash Roy, Ashok Kumar Choudhury
Journal: Journal of Hepatology (2024)
THU-322-YI Plasma cell-free mtDNA is released in alcohol-associated liver disease and correlates with liver injury
Authors: Maram Alenzi, Gao Wen, Heansika Matta, Pinzhu Huang, Disha Badlani, David Guardamino Ojeda, Gloria Horta, Michelle Lai, Z. Gordon Jiang, Yury Popov
Journal: Journal of Hepatology (2024)
SAT-295 Sarcopenia, frailty and growth hormone-insulin like growth factor axis among decompensated and alcohol-associated hepatitis patients
Authors: Aishani Wadhawan, Nipun Verma, Parminder Kaur, Pratibha Garg, Samonee Ralmilay, Rohit Nadda, Naveen Kalra, Sahaj Rathi, Arka De, Madhumita Premkumar, Sunil Taneja, Ajay Kumar Duseja, Virendra Singh
Journal: Journal of Hepatology (2024)
THU-324 Differential apoptotic and non-apoptotic cell death profiles in alcohol associated liver disease and their prognostic impact on acute-on-chronic liver failure
Authors: Pratibha Garg, Nipun Verma, Parminder Kaur, Samonee Ralmilay, Aishani Wadhawan, Rohit Nadda, Jiya Prajapati, Sahaj Rathi, Arka De, Madhumita Premkumar, Sunil Taneja, Ajay Kumar Duseja
Journal: Journal of Hepatology (2024)
THU-343 Dissecting metabolic dysfunction-associated steatotic liver disease with increased alcohol intake (MetALD): clinical and molecular insights and classification
Authors: Jun Liu, Sile Hu, Sihao Xiao, Rui Huang, Lingyan Chen, Jeremy Tomlinson, Jeremy Cobbold, Joanna Howson, Cornelia van Duijn
Journal: Journal of Hepatology (2024)
OS-094 Chronic HDV infection is sustained by an intense HBsAg production fromintegrated HBV-DNA in the setting of a limited or even absent HBV reservoir
Authors: Romina Salpini, Stefano D'Anna, Lorenzo Piermatteo, Giuseppina Brancaccio, Elisabetta Teti, Andrea Di Lorenzo, Ilaria Grossi, Giulia Torre, Vincenzo Malagnino, Marco Iannetta, Francesca Ceccherini Silberstein, Caterina Pasquazzi, Umberto Cillo, Alessandro Vitale, Enrico Gringeri, Maria Magrofuoco, Monia Pacenti, Leonardo Baiocchi, Simona Francioso, Ilaria Lenci, Apostolos Koffas, Anna Maria Geretti, Maria Lorena Abate, Antonella Olivero, Giovanni Battista Gaeta, Loredana Sarmati, Mario Rizzetto, Upkar Gill, Patrick Kennedy, Gian Paolo Caviglia, Valentina Svicher
Journal: Journal of Hepatology (2024)
SAT-318 Evaluating the life-saving potential of liver transplantation for acute-on-chronic liver failure with circulatory failure: an observational cohort study
Authors: Jinjin Luo, Peng Li, Meiqian Hu, Xi Liang, Jiaojiao Xin, Jing Jiang, Dongyan Shi, Huazhong Chen, Jinjun Chen, Yu Chen, Jun Li
Journal: Journal of Hepatology (2024)
SAT-267 The interaction between metabolic syndrome and alcohol consumption after an episode of alcohol-associated hepatitis is associated with increased mortality: results from de spanish registry of alcohol-associated liver disease (REHALC)
Authors: Jordi Gratacós-Ginès, María Del Barrio, PIlar Ruz-Zafra, Miriam Celada-Sendino, Ares Villagrasa, Federico Cáceres, Rosa Martin-Mateos, Luis Frisancho, Sonia García-García, Mónica Barreales Valbuena, Javier Tejedor-Tejada, Sergio Vaquez Rodriguez, Nuria Canete, Carlos Fernandez-Carrillo, Maria Valenzuela, David Marti-Aguado, Diana Horta, Marta Quinones, Vanesa Bernal, Silvia Acosta-López, Tomás Artaza, José Pinazo Bandera, Carmen Villar, Ana Clemente, Esther Badia-Aranda, Javier Crespo, Pau Sancho-Bru, Meritxell Ventura Cots, Conrado Fernández-Rodríguez, Victoria Aguilera Sancho, Santiago Tome, Ramon Bataller, Joan Caballeria, Joaquin Cabezas, Elisa Pose
Journal: Journal of Hepatology (2024)
SAT-284 Diagnostic performance of non-invasive tests in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) with increased alcohol intake (MetALD) in a primary care setting
Authors: Eileen Yoon, Jihyun An, Ha Il Kim, Joo Hyun Sohn, Huiyul Park, Sang Bong Ahn, Joo Hyun Oh, Hyunwoo Oh, Hyo Young Lee, Dae Won Jun
Journal: Journal of Hepatology (2024)
SAT-297 Recidivism and post-transplant outcomes in patients with alcohol-associated liver disease
Authors: Nilofar Najafian, Suaka Kagbo-Kue, Rachana Punukollu, Margaret C. Liu, Laura Budvytyte, Xingjie Li, Alyssa K. McGary, David M.H. Chascsa, Caroline Jadlowiec, Channa Jayasekera, Michele S. Barnhill, Rolland Dickson
Journal: Journal of Hepatology (2024)
OS-053 Screening candidates for therapeutic trials in MASH: choose the right non-invasive test for the diagnostic target considered
Authors: Jerome Boursier, Luisa Vonghia, Charlotte Costentin, Jeanne Fichez, Clemence Moreau, Marine Roux, Clémence M Canivet, Victor de Lédinghen, Sven Francque, Ming-Hua Zheng
Journal: Journal of Hepatology (2024)
TOP-062 Global epidemiology of acute kidney injury in hospitalized patients with cirrhosis: the ICA-GLOBAL AKI study
Authors: Kavish Patidar, Ann Thu Ma, Adrià Juanola, Anna Barone, Simone Incicco, Anand Kulkarni, José Luis Pérez-Hernàndez, Brian Wentworth, Sumeet Asrani, Carlo Alessandria, Nadia Abdelaaty Abdelkader, Yu Jun Wong, Qing Xie, Nikolaos T. Pyrsopoulos, Sung-Eun Kim, Yasser Fouad, Aldo Torre, Eira Cerda Reyes, Javier Diaz-Ferrer, Rakhi Maiwall, Douglas Simonetto, Maria Papp, Eric Orman, Giovanni Perricone, Cristina Sole, Christian M. Lange, Alberto Farias, Gustavo Pereira, Adrian Gadano, Paolo Caraceni, Thierry Thevenot, Nipun Verma, Jeong Han Kim, Julio D. Vorobioff, Jacqueline Cordova-Gallardo, Vladimir Ivashkin, Juan Pablo Roblero, Raoel Maan, Claudio Toledo, Oliviero Riggio, Eduardo Fassio, Monica Marino, Puria Nabilou, Victor Vargas, Manuela Merli, Luciana Lofego Goncalves, Liane Rabinowich, Aleksander Krag, Lorenz Balcar, Pedro Montes, Angelo Z. Mattos, Tony Bruns, Abdulsemed Mohammed Nur, Wim Laleman, Enrique Carrera Estupiñan, Maria Cecilia Cabrera, Marcos Girala, Hrishikesh Samant, Sarah Raevens, Joao Madaleno, W. Ray Kim, Juan Pablo Arab, José Presa, Carlos Noronha Ferreira, Antonio Galante, Andrew S. Allegretti, R. Bart Takkenberg, Murat Harputluoglu, Sebastián Marciano, Shiv Kumar Sarin, Pere Ginès, François Durand, Paolo Angeli, Elsa Solà, Salvatore Piano
Journal: Journal of Hepatology (2024)
SAT-292 Coinfection with viral hepatitis increases the short-term but not the long-term risks of hepatocellular carcinoma and hepatic events in adults with alcohol-related cirrhosis
Authors: Vicki Wing-Ki Hui, Terry Cheuk-Fung Yip, Zeyuan Yang, Ramsey C. Cheung, Robert Wong, Vincent Wai-Sun Wong, Grace Lai-Hung Wong
Journal: Journal of Hepatology (2024)
THU-340-YI Multiomics landscape of alcohol detoxification and the role of PNPLA3 genotype
Authors: Anna Karl, Katharina Remih, Franziska Hufnagel, Francesca Barletta, Mohamed Ali Jarboui, Johannes Müller, Sebastian Mueller, Zbyněk Zdráhal, David Potěšil, Pavel Hruška, Olivia Pleßow, Ulrike Rolle-Kampczyk, Martin von Bergen, Pavel Strnad
Journal: Journal of Hepatology (2024)
LBP-036 Final results from the phase 3 REGENERATE trial evaluating the effects of obeticholic acid in patients with pre-cirrhotic fibrosis due to metabolic dysfunction-associated steatohepatitis
Authors: Arun J. Sanyal, Rohit Loomba, Quentin M. Anstee, Vlad Ratziu, Kris V. Kowdley, Eric Lawitz, Christopher White, Sangeeta Sawhney, Thomas Capozza, Rina Leyva, Zobair Younossi, Mary E. Rinella, Manal F. Abdelmalek
Journal: Journal of Hepatology (2024)
FRI-059 Proton pump inhibitors are not associated with an increased risk of hepatic encephalopathy
Authors: Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Elise Jonasson Nielsen, Henrike Dobbermann, Philippe Sultanik, Peter R. Galle, Joachim Labenz, Dominique Thabut, Jens U. Marquardt, Patricia Bloom, Mette Lauridsen, Sara Montagnese, Christian Labenz
Journal: Journal of Hepatology (2024)
TOP-065 Outcomes of thromboelastography guided versus routine empirical oron-demand platelet transfusion in patients with liver cirrhosis and severe thrombocytopenia undergoing high-risk invasive percutaneous and vascular procedures: an open-label, randomized controlled trial
Authors: Sagnik Biswas, Shekhar Swaroop, Arnav Aggarwal, Tushar Sehgal, Manas Vaishnav, Ayush Agarwal, Abhinav Anand, Piyush Pathak, Shubham Mehta, Anshuman Elhence, Soumya Jagannath Mahapatra, Deepak Gunjan, Shivanand Gamangatti, Shalimar Shalimar
Journal: Journal of Hepatology (2024)
OS-106-YI TGR5 deficiency reduces angiocrine factor expression in liver sinusoidal endothelial cells and hepatocyte proliferation after partial hepatectomy
Authors: Impreet Kaur, Rajnish Tiwari, Pinky Juneja, Ashwini Vasudevan, Akash Kumar Mourya, Michael Trauner, Veronika Mlitz, Dinesh Mani Tripathi, Savneet Kaur
Journal: Journal of Hepatology (2024)
OS-098-YI Addition of simvastatin to carvedilol improves survival in patients with decompensated cirrhosis after variceal bleed. A randomised controlled trial
Authors: Randeep Rana, Tabish Mohammad, Samagra Agarwal, Rajkumar Bayye, Syed Ahmed, Deepak Gunjan, Sanchit Sharma, Anoop Saraya
Journal: Journal of Hepatology (2024)
SAT-421 Hepatitis B core related antigen in South Africa and the United Kingdom-does one size fit all?
Authors: Louise Downs, Marion Delphin, Tingyan Wang, Cori Campbell, Catherine De Lara, Sheila Lumley, Sue Wareing, Polly Fengou, Tongai Gibson Maponga, Marije Van Schalkwyk, Shiraaz Gabriel, Susan Hugo, Monique Andersson, Jacqueline Martin, Elizabeth Waddilove, Kosh Agarwal, Geoffrey Dusheiko, Ivana Carey, Wolfgang Preiser, Eleanor Barnes, Gavin Kelly, Philippa CMatthews
Journal: Journal of Hepatology (2024)
THU-263-YI Significance of adipose tissue fibrosis and adipocyte in the progression of metabolic dysfunction-associated steatohepatitis in severe obesity patients
Authors: Andrea Jiménez-Franco, Marina Ramirez-Baños, Cristina Placed-Gallego, Juan Manuel Jiménez-Aguilar, Cristian Martínez-Navidad, Helena Castañé, Alina-Iuliana Onoiu, Vicente Cambra-Cortes, Jordi Camps, Jorge Joven
Journal: Journal of Hepatology (2024)
WED-392 Improvement in liver histology is observed in most patients with chronic hepatitis delta after 48weeks of bulevirtide monotherapy
Authors: Pietro Lampertico, Soo Aleman, Pavel Bogomolov, Tatyana Stepanova, Markus Cornberg, Sandra Ciesek, Annemarie Berger, Dmitry Manuilov, Mingyang Li, Audrey H. Lau, Ben L. Da, Grace M. Chee, Maurizia Brunetto, Stefan Zeuzem, Heiner Wedemeyer
Journal: Journal of Hepatology (2024)
SAT-337 Serum levels of IgA inform on the transcriptomic architecture of the liver and predict hepatocellular carcinoma in chronic viral hepatitis patients
Authors: Nicolaas Van Renne, Stijn Van Hees, Bart Cuypers, Arno Furquim d'Almeida, Axelle Vanderlinden, Pieter Meysman, Jordan J. Feld, Paloma Sangro, Stefan Bourgeois, Dirk Sprengers, Geert Robaeys, Luisa Vonghia, Peter Michielsen, Sven Francque, Bruno Sangro, Owen Cain, Ahmed M Elsharkawy, Robert A. de Man, Andre Boonstra, Harry Janssen, Ann Driessen, Kris Laukens, Thomas Vanwolleghem
Journal: Journal of Hepatology (2024)
FRI-248-YI The impact of baseline sarcopenia, over time, on liver and cardiovascular damage in patients with metabolic-dysfunction associated steatotic liver disease (MASLD): a prospective study
Authors: Floriana Santomenna, Annalisa Cespiati, Matteo Carlomagno, Giovanna Oberti, Edoardo Pulixi, Jaqueline Currà, Daniel Smith, Rosa Lombardi, Erika Fatta, Cristina Bertelli, Giuseppina Pisano, Anna Ludovica Fracanzani
Journal: Journal of Hepatology (2024)
SAT-403 Vitamin D supplementation accelerated reduction of HBsAg levels in patients with chronic hepatitis B requiring treatment and in inactive carrier phase
Authors: Thitaporn Roongrawee, Sirinporn Suksawatamnuay, Panarat Thaimai, Prooksa Ananchuensook, Supachaya Sriphoosanaphan, Kessarin Thanapirom, Piyawat Komolmit
Journal: Journal of Hepatology (2024)
FRI-394 High burden of cirrhosis and increasing response rates to bulevirtide-based regimens: insights from the austrian prospective hepatitis D registry
Authors: Michael Schwarz, Caroline Schwarz, David Bauer, Marlene Panzer, Michael Strasser, Silvia Reiter, Livia Dorn, Andreas Maieron, Alexander Moschen, Elmar Aigner, Michael Trauner, Albert Friedrich Stättermayer, Mattias Mandorfer, Heinz Zoller, Michael Gschwantler, Thomas Reiberger, Mathias Jachs
Journal: Journal of Hepatology (2024)
FRI-274 Persistence of fatty liver index (FLI) ≥20 as a predictor for hepatocellular carcinoma (HCC) development in non-HBV/non-HCV infected population
Authors: Rachel Wen-Juei Jeng, Mei-Hung Pan, Yi-Chung Hsieh, Hwai-I Yang
Journal: Journal of Hepatology (2024)
SAT-213 Postbiotic supplementation for metabolic dysfunction-associated steatotic liver disease
Authors: Maryana Savytska, Olena Baka, Elina Manzhalii, Dmytro Kyriienko, Tetyana Falalyeyeva, Maksym Zhayvoronok, Oleksandr Kovalchuk, Nataliya Deresh, Fedir Grygoriev, Nazarii Kobyliak
Journal: Journal of Hepatology (2024)
WED-281-YI A non-invasive score model for prediction of significant fibrosis and fibrotic metabolic dysfunction-associated steatohepatitis based on serum biomolecules
Authors: Nateneal Beyene, Wilhelmus J Kwanten, Lotte Schoenmakers, Jolien Derdeyn, Toon Steinhauser, Thomas Vanwolleghem, Ann Driessen, Sven Francque, Luisa Vonghia
Journal: Journal of Hepatology (2024)
THU-258-YI Altered liver vascular biology occurring in early stages of metabolic dysfunction-associated steatotic liver disease is significantly improved by the pan-peroxisome proliferatoractivated receptoragonist lanifibranor, associating with improved liver histology
Authors: Shivani Chotkoe, Guillaume Wettstein, Luisa Vonghia, Denise van der Graaff, Joris De Man, Benedicte De Winter, Pierre Broqua, Jean-Louis Junien, Wilhelmus Kwanten, Sven Francque
Journal: Journal of Hepatology (2024)
SAT-405 Differential expression and sequence variants of sodium taurocholate cotransporting polypeptide (NTCP) do not affect HDV inhibition by Bulevirtide (BLV)
Authors: Simin Xu, Thomas Aeschbacher, Savrina Manhas, Chunfeng Li, Ross Martin, Yang Liu, Evguenia Maiorova, Hongmei Mo, Roberto Mateo
Journal: Journal of Hepatology (2024)
THU-202 Prophylactic and therapeutic hepatoprotective effects of the dual FXR/TGR5 agonist INT-767 in the GAN diet-induced ob/ob mouse model of advanced MASH with progressive fibrosis
Authors: Jacob Nøhr-Meldgaard, Susanne Pors, Rebecca Wendelbo Olsen, Henrik B. Hansen, Michael Feigh
Journal: Journal of Hepatology (2024)
SAT-392 Perturbed pathways of lipid metabolism in patients with chronic hepatitis B infection after cessation of long term nucleos (t)ide analogue
Authors: Fengge Zhu, Rex Wan-Hin Hui, Liqiong Yang, Saisai Zhang, Jiaqi Wang, Xue Li, Tsz Yan Kwok, James Fung, Wai-Kay Seto, Man-Fung Yuen, Lung Yi Loey Mak
Journal: Journal of Hepatology (2024)
WED-399-YI The composition of HBsAg along with HDV-RNA predicts virological response in chronic hepatitis delta patients treated with bulevirtide for 48 weeks
Authors: Stefano D'Anna, Romina Salpini, Elisabetta Degasperi, Leonardo Duca, Maria Paola Anolli, Lorenzo Piermatteo, Dana Sambarino, Marta Borghi, Floriana Facchetti, Francesca Ceccherini Silberstein, Riccardo Perbellini, Pietro Lampertico, Valentina Svicher
Journal: Journal of Hepatology (2024)
THU-268 Differential transcriptomic profile in platelet-derived extracellular vesicles in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Authors: Sheila Gato-Zambrano, Rocío Munoz-Hernández, Antonio Gil-Gómez, Ángela Rojas Álvarez-Ossorio, Vanessa García-Fernández, Rocío Gallego-Durán, Rocío Montero-Vallejo, Douglas Maya, Raquel Millán-Dominguez, M. Carmen Rico, Isabel Fernández-Lizaranzu, Javier Ampuero, Manuel Romero-Gomez
Journal: Journal of Hepatology (2024)
FRI-286 Muscle function and walking time are associated with better quality of life in MASLD patients
Authors: Roberta Forlano, Thishana Kirupakaran, Margaux Couffon, Beatrice Martino, Giordano Sigon, Jian Huang, Benjamin H. Mullish, Michael Yee, Mark R. Thursz, Pinelopi Manousou
Journal: Journal of Hepatology (2024)
FRI-290 Evaluation of ChatGPT as a counselling tool for Italian-speaking MASLD patients: assessment of accuracy, completeness and comprehensiveness
Authors: Nicola Pugliese, Davide Polverini, Rosa Lombardi, Grazia Pennisi, Federico Ravaioli, Angelo Armandi, Elena Buzzetti, Andrea Dalbeni, Antonio Liguori, Alessandro Mantovani, Rosanna Villani, Cesare Hassan, Luca Valenti, Luca Miele, Salvatore Petta, Giada Sebastiani, Alessio Aghemo
Journal: Journal of Hepatology (2024)
THU-275 Interleukin 10 reduces fat accumulation and promotes fatty acid degradation and intracellular glucose maintenance in a high-fatdiet mouse model of metabolic dysfunction-associated steatotic liver disease
Authors: Akira Kado, Kazuya Okushin, Takeya Tsutsumi, Kazuhiko Ikeuchi, Kyoji Moriya, Hiroshi Yotsuyanagi, Kazuhiko Koike, Mitsuhiro Fujishiro
Journal: Journal of Hepatology (2024)
Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig
Authors: Miriam Manook, Danae Olaso, Imran Anwar, Isabel DeLaura, Janghoon Yoon, Yeeun Bae, Andrew Barbas, Brian Shaw, Dimitrios Moris, Mingqing Song, Alton B. Farris, Kathryn Stiede, Michele Youd, Stuart Knechtle, Jean Kwun
Journal: Science Translational Medicine (2024)

Genetic modification of porcine donors, combined with optimized immunosuppression, has been shown to improve outcomes of experimental xenotransplant. However, little is known about outcomes in sensitized recipients, a population that could potentially benefit the most from the clinical implementation of xenotransplantation. Here, five highly allosensitized rhesus macaques received a porcine kidney from