tbuckley/cabot-search huggingface dataset:
Large B-cell lymphomas with CCND1 rearrangement have different immunoglobulin gene breakpoints and genomic profile than mantle cell lymphoma
Authors: Ece Özoğul, Anna Montaner, Melina Pol, Gerard Frigola, Olga Balagué, Charlotte Syrykh, Pablo Bousquets-Muñoz, Romina Royo, Juliette Fontaine, Alexandra Traverse-Glehen, Marco M. Bühler, Luca Giudici, Marco Roncador, Thorsten Zenz, Sylvain Carras, Severine Valmary-Degano, Laurence de Leval, Jan Bosch-Schips, Fina Climent, Julia Salmeron-Villalobos, Melika Bashiri, Silvia Ruiz-Gaspà, Dolors Costa, Sílvia Beà, Itziar Salaverria, Eva Giné, Leticia Quintanilla-Martinez, Pierre Brousset, Mark Raffeld, Elaine S. Jaffe, Xose S. Puente, Cristina López, Ferran Nadeu, Elias Campo
Journal: Blood Cancer Journal (2024)

Mantle cell lymphoma (MCL) is genetically characterized by the IG::CCND1 translocation mediated by an aberrant V(D)J rearrangement. CCND1 translocations and overexpression have been identified in occasional aggressive B-cell lymphomas with unusual features for MCL. The mechanism generating CCND1 rearrangements in these tumors and their genomic profile are not known. We have reconstructed the IG::CCND1 translocations and the genomic profile of 13 SOX11-negative aggressive B-cell lymphomas using whole genome/exome and target sequencing. The mechanism behind the translocation was an aberrant V(D)J rearrangement in three tumors and by an anomalous IGH class-switch recombination (CSR) or somatic hypermutation (SHM) mechanism in ten. The tumors with a V(D)J-mediated translocation were two blastoid MCL and one high-grade B-cell lymphoma. None of them had a mutational profile suggestive of DLBCL. The ten tumors with CSR/SHM-mediated IGH::CCND1 were mainly large B-cell lymphomas, with mutated genes commonly seen in DLBCL and BCL6 rearrangements in 6. Two cases, which transformed from marginal zone lymphomas, carried mutations in KLF2, TNFAIP3 and KMT2D. These findings expand the spectrum of tumors carrying CCND1 rearrangement that may occur as a secondary event in DLBCL mediated by aberrant CSR/SHM and associated with a mutational profile different from that of MCL.
The Role of Online Well-Being Therapy in Overcoming Allostatic Overload in Medical Workers: A Pilot Randomized Controlled Study
Authors: Xiaolei Liu, Penghui Song, Lu Yin, Kun Wang, Boheng Zhu, Xiaomin Huang, Yanyan Niu, Haixia Leng, Qing Xue, Mao Peng, Baoquan Min, Fangfang Shangguan, Peiran Zhang, Wenfeng Zhao, Huang Wang, Jing Lv, Mei Yang, Ping Wang, Dongning Li, Xiaoling Gao, Kun Feng, Keming Yun, Fiammetta Cosci, Hongxing Wang
Journal: Psychotherapy and Psychosomatics (2024)

Introduction: Stress may lead to allostatic overload. Well-being therapy (WBT) might mitigate it by enhancing psychological well-being and protecting from psychological symptoms. Since no reports are available on the use of WBT in allostatic overload, we evaluated online WBT effects in reducing allostatic overload in medical workers during the coronavirus pandemic. Methods: Sixty-six participants with allostatic overload were enrolled and randomly assigned to eight sessions of online WBT (n = 32) or eight sessions of an online psychoeducation program on healthy lifestyle (CON) (n = 34). The primary outcome was the prevalence rate of allostatic overload in the two groups at session 8 (T2). Secondary analyses were performed on changes in the PsychoSocial Index (PSI) and Psychological Well-Being (PWB) scales scores at the same time points. Generalized estimating equation models were employed. Results: The WBT group showed a significantly lower rate of allostatic overload at T2 than the CON group (28.13% vs. 70.59%, p &amp;lt; 0.001); similar results were found at T1, T3, and T4 (p &amp;lt; 0.001). Compared to CON, WBT produced a significant decrease in psychological distress (p &amp;lt; 0.001) and abnormal illness behavior (p = 0.031), as well as a significant improvement in PWB autonomy, environmental mastery, personal growth, positive relations with others, purpose in life, and self-acceptance (p &amp;lt; 0.001). Conclusion: Online WBT may be an effective non-pharmacological therapeutic strategy for individuals with allostatic overload. These findings need to be further validated in different clinical populations.
Tracking Community Outreach and Engagement Activities among National Cancer Institute-Designated Cancer Centers
Authors: Todd Burus, Caree R McAfee, Pamela C Hull, Amy E Leader, Christopher McNair
Journal: JNCI Journal of the National Cancer Institute (2024)

The National Cancer Institute's (NCI) Cancer Center Support Grant mandates that NCI-Designated Cancer Centers establish a Community Outreach and Engagement (COE) component to help direct efforts at reducing cancer burden within their catchment areas. Despite the critical role of COE offices, little is known about how they track and evaluate outreach activities and outcomes. We gathered information on current practices from representatives of 40 out of 65 COE offices using an online survey. While nearly all responding centers (97.5%) tracked COE activities, no consensus existed on resources used and satisfaction with current solutions was mixed (51.0% not satisfied). Respondents expressed need for a centralized, standardized, and comprehensive tracking solution to capture outreach events and external partnerships, automate report generation, and ensure alignment with COE aims. This study highlights challenges COE offices face with resource limitations and a heterogeneity of activities to track, and the need for a standard evaluation framework.
Quantifying Triglyceride-Rich Lipoprotein Atherogenicity, Associations With Inflammation, and Implications for Risk Assessment Using Non-HDL Cholesterol
Authors: Elias Björnson, Martin Adiels, Anders Gummesson, Marja-Riitta Taskinen, Stephen Burgess, Chris J Packard, Jan Borén
Journal: Journal of the American College of Cardiology (2024)
Quality Indicators for Pain in Adults: A Review of Performance Measures by the American College of Physicians
Authors: Amir Qaseem, Karen Campos, Scott MacDonald, Cristin Mount, Samantha Tierney
Journal: Annals of Internal Medicine (2024)

Pain is a debilitating symptom generally caused by injuries or various conditions. It can be acute, subacute, or chronic and can have a significant impact on a patient's quality of life. The goal of managing pain is to relieve or reduce suffering and improve patient functioning. Several performance measures that address the treatment of pain are used in payment, public reporting, or accountability programs. The American College of Physicians (ACP) embraces performance measurement as a means to improve quality of care. ACP believes that a performance measure must be methodologically sound and evidence-based to be considered for inclusion in payment, accountability, or reporting programs. However, a plethora of performance measures that provide minimal or no value to patient care have inundated physicians, practices, and systems with the burden of collecting and reporting data. ACP's Performance Measurement Committee (PMC) reviews performance measures using a validated process to recognize high-quality performance measures, address gaps and areas for improvement in performance measures, and help reduce reporting burden. There is a need for a higher standard for a performance measure when reputation and reimbursement are on the line. This paper aims to present a review of current performance measures for pain to inform physicians, payers, and policymakers in their selection and use of performance measures. The PMC reviewed 6 performance measures for pain relevant to internal medicine physicians, of which 3 were considered valid at their intended levels of attribution ("Use of Imaging for Low Back Pain," "Use of Opioids at High Dosage in Persons Without Cancer," and "Use of Opioids From Multiple Providers in Persons Without Cancer"). This paper also proposes a performance measure concept to address a quality-of-care gap based on the current clinical guideline from ACP and the American Academy of Family Physicians, "Nonpharmacologic and Pharmacologic Management of Acute Pain From Non-low Back, Musculoskeletal Injuries in Adults."
Relationship Between Control of Cardiovascular Risk Factors and Chronic Kidney Disease Progression, Cardiovascular Disease Events, and Mortality in Chinese Adults
Authors: Tingting Geng, Wenqi Xu, Huanqing Gao, Jijuan Zhang, Jiaojiao Zou, Kaiyue Wang, Junjuan Li, Lu Guo, Guodong Wang, Shuohua Chen, Tao Huang, An Pan, Xiang Gao, Shouling Wu
Journal: Journal of the American College of Cardiology (2024)
Artificial Intelligence–Supported Development of Health Guideline Questions
Authors: Bernardo Sousa-Pinto, Rafael José Vieira, Manuel Marques-Cruz, Antonio Bognanni, Sara Gil-Mata, Slava Jankin, Joana Amaro, Liliane Pinheiro, Marta Mota, Mattia Giovannini, Leticia de las Vecillas, Ana Margarida Pereira, Justyna Lityńska, Boleslaw Samolinski, Jonathan Bernstein, Mark Dykewicz, Martin Hofmann-Apitius, Marc Jacobs, Nikolaos Papadopoulos, Sian Williams, Torsten Zuberbier, João A. Fonseca, Ricardo Cruz-Correia, Jean Bousquet, Holger J. Schünemann
Journal: Annals of Internal Medicine (2024)

Guideline questions are typically proposed by experts.
Patiromer Facilitates Angiotensin Inhibitor and Mineralocorticoid Antagonist Therapies in Patients With Heart Failure and Hyperkalemia
Authors: Bertram Pitt, Stefan D. Anker, Lars H. Lund, Andrew J.S. Coats, Gerasimos Filippatos, Patrick Rossignol, Matthew R. Weir, Tim Friede, Mikhail N. Kosiborod, Marco Metra, Michael Böhm, Justin A. Ezekowitz, Antoni Bayes-Genis, Robert J. Mentz, Piotr Ponikowski, Michele Senni, Ileana L. Piña, Fausto J. Pinto, Peter van der Meer, Cecilia Bahit, Jan Belohlavek, Jasper J. Brugts, Amandine Perrin, Sandra Waechter, Jeffrey Budden, Javed Butler
Journal: Journal of the American College of Cardiology (2024)
Immunomodulatory hydrogel orchestrates pro-regenerative response of macrophages and angiogenesis for chronic wound healing
Authors: Chen-Hsiang Kuan, Ling Chang, Chia-Yu Ho, Chia-Hsuan Tsai, Yu-Chung Liu, Wei-Yuan Huang, Yi-Ning Wang, Wei-Hung Wang, Tzu-Wei Wang
Journal: Biomaterials (2024)
Powering up targeted protein degradation through active and passive tumour-targeting strategies: Current and future scopes
Authors: Janarthanan Venkatesan, Dhanashree Murugan, Kalaiarasu Lakshminarayanan, Alexis R Smith, Harashkumar Vasanthakumari Thirumalaiswamy, Hariprasath Kandhasamy, Boutheina Zender, Guangrong Zheng, Loganathan Rangasamy
Journal: Pharmacology & Therapeutics (2024)
Revamping anti-cGAS-STING therapy via an injectable thermo-responsive supramolecular hydrogel for pathological retinal Angiogenesis
Authors: Dan Yan, Yuqian Wang, Weijie Ouyang, Caihong Huang, Qian Chen, Jiaoyue Hu, Zuguo Liu
Journal: Asian Journal of Pharmaceutical Sciences (2024)

Retinal neovascularization is a leading cause of blindness. While current anti-VEGF drugs effectively inhibit pathological angiogenesis, some patients develop resistance or reduced responsiveness to treatments over time, leading to diminished effectiveness. In this study, we identified high activation of the cGAS-STING signaling pathway, which exacerbated pathological neovascularization and vessel leakage. We developed an injectable thermo-responsive supramolecular hydrogel loaded with an anti-STING drug. The hydrogel, made of Pluronic F127 (PF·127) consisting of poly(ethylene oxide) and poly(propylene oxide) units, demonstrated excellent transparency and biocompatibility. Importantly, the thermo-sensitive property allowed for precise spatial release of the drug, extending the effective treatment duration of C-176, which suppressed STING activation in the retina, reduced inflammation, and protected retinal tissue. Hydro
Exploring the incidence of dysplasia or adenocarcinoma in early onset Barrett’s esophagus
Authors: Irma C. Noordzij, Clément J. Huysentruyt, Wouter L. Curvers, Gesina van Lijnschoten, Ad A. M. Masclee, Erik J. Schoon
Journal: Endoscopy (2024)

Currently data on the risk of progression to and lifetime risk of cancer are not available for patients with young onset Barrett's esophagus (BE). Our aim was to obtain epidemiologic data on the incidence of dysplasia or adenocarcinoma in young onset BE in the Netherlands by collecting data on all histologically confirmed cases over a prolonged period of 25 years between January 1, 1991 and December 31, 2015.
Re: Robert Seifert, Louise Emmett, Steven P. Rowe, et al. Second Version of the Prostate Cancer Molecular Imaging Standardized Evaluation Framework Including Response Evaluation for Clinical Trials (PROMISE V2). Eur Urol 2023;83:405–12
Authors: Marcus Unterrainer, Lena M Unterrainer, Harun Ilhan
Journal: European Urology (2024)
Decellularized liver scaffolds for constructing drug-metabolically functional ex vivo human liver models
Authors: Juan Liu, Ariel Hanson, Wenzhen Yin, Qiao Wu, Eliane Wauthier, Jinmei Diao, Timothy Dinh, Jeff Macdonald, Ruihong Li, Masahiko Terajima, Mitsuo Yamauchi, Ziye Chen, Praveen Sethupathy, Jiahong Dong, Lola M Reid, Yunfang Wang
Journal: Bioactive Materials (2024)
Food insecurity, dietary inadequacy, and malnutrition in the Gaza Strip: a cross-sectional nutritional assessment of refugee children entering the first grade of UNRWA schools and their households before the conflict of 2023–24
Authors: Masako Horino, Randa Zaqqout, Rami Habash, Shatha Albaik, Yehia Abed, Ghada Al-Jadba, Keith P West, Akihiro Seita
Journal: The Lancet Global Health (2024)
Spleen stiffness measurement by vibration-controlled transient elastography at 100 Hz for non-invasive predicted diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease: a modelling study
Authors: Mathias Jachs, Aitor Odriozola, Fanny Turon, Lucile Moga, Luis Téllez, Petra Fischer, Dario Saltini, Wilhelmus J Kwanten, Maria Grasso, Elba Llop, Yuly P Mendoza, Angelo Armandi, Julia Thalhammer, Carlos Pardo, Antonio Colecchia, Federico Ravaioli, Benjamin Maasoumy, Wim Laleman, José Presa, Jörn M Schattenberg, Annalisa Berzigotti, José L Calleja, Vincenza Calvaruso, Sven Francque, Filippo Schepis, Bogdan Procopet, Agustín Albillos, Pierre-Emmanuel Rautou, Juan C García-Pagán, Ángela Puente, José I Fortea, Thomas Reiberger, Mattias Mandorfer
Journal: The Lancet. Gastroenterology & hepatology (2024)
Dysglycaemia screening and its prognostic impact in patients with coronary artery disease: experiences from the EUROASPIRE IV and V cohort studies
Authors: Giulia Ferrannini, Jaakko Tuomilehto, Guy De Backer, Kornelia Kotseva, Linda Mellbin, Oliver Schnell, David Wood, Dirk De Bacquer, Lars Rydén
Journal: The Lancet Diabetes & Endocrinology (2024)
The respiratory syncytial virus vaccine and monoclonal antibody landscape: the road to global access
Authors: Jonne Terstappen, Sarah F Hak, Anant Bhan, Debby Bogaert, Louis J Bont, Ursula J Buchholz, Andrew D Clark, Cheryl Cohen, Ron Dagan, Daniel R Feikin, Barney S Graham, Anuradha Gupta, Pradeep Haldar, Rose Jalang'o, Ruth A Karron, Leyla Kragten, You Li, Yvette N Löwensteyn, Patrick K Munywoki, Rosemary Njogu, Ab Osterhaus, Andrew J Pollard, Luiza Reali Nazario, Charles Sande, Ashish R Satav, Padmini Srikantiah, Renato T Stein, Naveen Thacker, Rachael Thomas, Marta Tufet Bayona, Natalie I Mazur
Journal: The Lancet Infectious Diseases (2024)
Reply to Feng Qi’s Letter to the Editor re: Niklas Klümper, Viktor Grünwald, Arndt Hartmann, et al. The Role of Microsatellite Instability/DNA Mismatch Repair Deficiency and Tumor Mutational Burden as Biomarkers in Predicting Response to Immunotherapy in Castration-resistant Prostate Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2024.04.026
Authors: Niklas Klümper, Markus Eckstein
Journal: European Urology (2024)
Exploring the potential of laser-textured metal alloys: Fine-tuning vascular cells responses through in vitro and ex vivo analysis
Authors: Indong Jun, Haneul Choi, Hyeok Kim, Byoung Chan Choi, Hye Jung Chang, Youngjun Kim, Sung Woo Cho, James R Edwards, Suk-Won Hwang, Yu-Chan Kim, Hyung-Seop Han, Hojeong Jeon
Journal: Bioactive Materials (2024)
A polymer nanogel-based therapeutic nanovaccine for prophylaxis and direct treatment of tumors via a full-cycle immunomodulation
Authors: Yunqi Guo, Zhiqiang Wang, Gaoming Li, Mengsi Zhan, Tingting Xiao, Jianhong Wang, Jan C M van Hest, Xiangyang Shi, Mingwu Shen
Journal: Bioactive Materials (2024)
Single-cell RNA-sequencing reveals anti-tumor potency of CD56+ NK cells and CD8+ T cells in humanized mice via PD-1 and TIGIT co-targeting
Authors: Wai Nam Liu, Sarah L Harden, Shawn Lu Wen Tan, Rachel Jun Rou Tan, Shin Yie Fong, Sue Yee Tan, Min Liu, Isha Karnik, Timothy Wai Ho Shuen, Han Chong Toh, Yong Fan, Seng Gee Lim, Jerry Kok Yen Chan, Qingfeng Chen
Journal: Molecular Therapy (2024)
Long COVID: what do we know now and what are the challenges ahead?
Authors: Snehal M Pinto Pereira, Fiona Newlands, Jake Anders, Amitava Banerjee, Sarah Beale, Ann Blandford, Kate Brown, Feifei Bu, Wing Lam Erica Fong, Gina Gilpin, Pia Hardelid, Jana Kovar, Jason Lim, Chloe Park, Vishnuga Raveendran, Anoop D Shah, Xin Shao, Andrew Wong, Terence Stephenson, Roz Shafran
Journal: Journal of the Royal Society of Medicine (2024)
PSFHS Challenge Report: Pubic Symphysis and Fetal Head Segmentation from Intrapartum Ultrasound Images
Authors: Jieyun Bai, Zihao Zhou, Zhanhong Ou, Gregor Koehler, Raphael Stock, Klaus Maier-Hein, Marawan Elbatel, Robert Martí, Xiaomeng Li, Yaoyang Qiu, Panjie Gou, Gongping Chen, Lei Zhao, Jianxun Zhang, Yu Dai, Fangyijie Wang, Guénolé Silvestre, Kathleen Curran, Hongkun Sun, Jing Xu, Pengzhou Cai, Lu Jiang, Libin Lan, Dong Ni, Mei Zhong, Gaowen Chen, Víctor M Campello, Yaosheng Lu, Karim Lekadir
Journal: Medical Image Analysis (2024)
Microfluidic formulation, cryoprotection and long-term stability of paclitaxel-loaded π electron-stabilized polymeric micelles
Authors: Rahaf Mihyar, Armin Azadkhah Shalmani, Viktor Wildt, Maryam Sheybanifard, Alec Wang, Jan-Niklas May, Saba Shahzad, Eva Miriam Buhl, Stephan Rütten, Diana Behrens, Wolfgang Walther, Mattia Tiboni, Luca Casettari, Johannes F Buyel, Cristianne J F Rijcken, Wim E Hennink, Saskia von Stillfried, Fabian Kiessling, Yang Shi, Josbert M Metselaar, Twan Lammers, Quim Peña
Journal: Journal of Controlled Release (2024)
Egfl6 promotes ovarian cancer progression by enhancing the immunosuppressive functions of tumor-associated myeloid cells
Authors: Sarah Hamze Sinno, Joshua A Imperatore, Shoumei Bai, Noémie Gomes-Jourdan, Nyasha Mafarachisi, Claudia Coronnello, Linan Zhang, Eldin Jašarević, Hatice U Osmanbeyoglu, Ronald J Buckanovich, Sandra Cascio
Journal: Journal of Clinical Investigation (2024)

Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) play a critical role in resistance to immunotherapy. In this study, we identified epidermal growth factor-like 6 (Egfl6) as a new regulator of myeloid cell functions. Our analyses indicated that Egfl6, via binding with β3 integrins and activation of p38 and SYK signaling, acts as a chemotactic factor for myeloid cells migration and promotes their differentiation towards an immunosuppressive state. In syngeneic mouse models of ovarian cancer (OvCa), tumor expression of Egfl6 increased the intra-tumoral accumulation of polymorphonuclear (PMN) MDSCs and TAMs and their expression of immunosuppressive factors, including CXCL2, IL-10 and PD-L1. Consistent with this, in an immune 'hot' tumor model, Egfl6 expression eliminated response to a-PD-L1 therapy, while Egfl6 neutralizing antibody decreased the accumulation of tumor-infiltrating CD206+ TAMs and PMN-MDSCs and restored the efficacy of a-PD-L1 therapy. Supporting a role in human tumors, in human OvCa tissue samples, areas of high EGFL6 expression co-localized with myeloid cell infiltration. scRNAseq analyses revealed a correlation between EGFL6 and immune cell expression of immunosuppressive factors. Our data provide mechanistic insights into the onco-immunologic functions of EGFL6 in mediating tumor immune suppression and identified EGFL6 as a potential novel therapeutic target to enhance immunotherapy in OvCa patients.
How can quantum computing be applied in clinical trial design and optimization?
Authors: Hakan Doga, Aritra Bose, M Emre Sahin, Joao Bettencourt-Silva, Anh Pham, Eunyoung Kim, Alan Andress, Sudhir Saxena, Laxmi Parida, Jan Lukas Robertus, Hideaki Kawaguchi, Radwa Soliman, Daniel Blankenberg
Journal: Trends in Pharmacological Sciences (2024)
CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway
Authors: Canhui Cao, Miaochun Xu, Ye Wei, Ting Peng, Shitong Lin, Xiaojie Liu, Yashi Xu, Tian Chu, Shiyi Liu, Ping Wu, Bai Hu, Wencheng Ding, Li Li, Ding Ma, Peng Wu
Journal: Cell Genomics (2024)
Disruption of branched-chain amino acid homeostasis promotes the progression of DKD via enhancing inflammation and fibrosis-associated epithelial-mesenchymal transition
Authors: Xiaoqing Deng, Chao Tang, Ting Fang, Ting Li, Xiaoyu Li, Yajin Liu, Xuejiao Zhang, Bei Sun, Haipeng Sun, Liming Chen
Journal: Metabolism (2024)
Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease
Authors: Wei Guo, Ziyi Li, Gerasimos Anagnostopoulos, Wan Ting Kong, Shuangyan Zhang, Svetoslav Chakarov, Amanda Shin, Jiawen Qian, Yiwen Zhu, Wenjuan Bai, Olivier Cexus, Bin'en Nie, Jing Wang, Xiaoyu Hu, Camille Blériot, Zhaoyuan Liu, Baiyong Shen, Nicolas Venteclef, Bing Su, Florent Ginhoux
Journal: Immunity (2024)
Utility of genomic testing in children, adolescents, and young adults with cancer
Authors: Emily Debortoli, Ella Mcgahan, Tatiane Yanes, Jennifer Berkman, Noemi Fuentes-Bolanos, Vivienne Milch, Julia Steinberg, Aideen Mcinerney-Leo
Journal: JNCI Journal of the National Cancer Institute (2024)

Genomic testing can inform the diagnosis and personalise management of cancers in children, adolescents, and young adults (CAYA). This scoping review explored the clinical utility and impact of genomic testing in general CAYA cancer cohorts. Relevant records published in English between 2017-2024 were identified by searching PubMed. 36 studies (32 original articles; 4 reviews) were identified on genomic testing in CAYA cancers, most of which were advanced cancers. Studies internationally reported that approximately 16-18% of CAYAs with cancer carry an associated pathogenic germline variant where 40% are de-novo, and can guide treatment (eg, DNA repair gene variants). Somatic variants, predominantly copy number or structural rearrangements, inform diagnosis in up to 95% of primary cancers. Between 18-69% of patients have a somatic variant with a matched therapy, but only one third receive the genomic-guided recommendation, predominantly due to declining patient condition. Few studies evaluated the impact of matched therapies on response and survival. Combining comprehensive DNA and RNA sequencing maximises sensitivity. Circulating tumour DNA was detected in most primary cancers and shows high concordance with tumour tissue. In conclusion, genomic testing of CAYA cancers is feasible, informs diagnoses and guides personalised care. Further research is needed on response to genomic-guided treatments.
IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis
Authors: Peng Zhang, Junlai Liu, Allen Lee, Irene Tsaur, Masafumi Ohira, Vivian Duong, Nicholas Vo, Kosuke Watari, Hua Su, Ju Youn Kim, Li Gu, Mandy Zhu, Shabnam Shalapour, Mojgan Hosseini, Gautam Bandyopadhyay, Suling Zeng, Cristina Llorente, Haoqi Nina Zhao, Santosh Lamichhane, Siddharth Mohan, Pieter C Dorrestein, Jerrold M Olefsky, Bernd Schnabl, Pejman Soroosh, Michael Karin
Journal: Cell Metabolism (2024)
Effect of Cross-Platform Variations on Transthoracic Echocardiography Measurements and Clinical Diagnosis
Authors: Mohammad Saber Hashemi, Yasaman Farsiani, Gregg S Pressman, M Reza Amini, Arash Kheradvar
Journal:  (2024)

Accurate cardiac chamber quantification is essential for clinical decisions and ideally should be consistent across different echocardiography systems. This study evaluates variations between the Philips EPIQ CVx (version 9.0.3) and Canon Aplio i900 (version 7.0) in measuring cardiac volumes, ventricular function, and valve structures.