tbuckley/cabot-search huggingface dataset:
Abstract 4649: A Radiofrequency HOT Balloon Catheter for Isolating the Posterior Left Atrium Including All the Pulmonary Veins in the Treatment of Atrial Fibrillation: Feasibility and Safety of a New Approach
Authors: Hiroshi Sohara, Shutaro Satake, Hiroshi Takeda, Hideki Ueno, Toshimichi Oda
Journal: Circulation (2008)

Atrial fibrillation (AF) is originated from mostly from pulmonary vein (PV) foci or non-PV foci in the posterior left atrium (PLA). The present study was designed to evaluate the usefulness of a radiofrequency HOT balloon catheter (RBC) for isolation of the PLA including all PVs en masse in the patients with AF. In a total of 96 patients (75 men and 21 women; mean age 64±8 years old) with drug-resistant paroxysmal (n=63) and persistent AF(n=33), PLA including all PVs were ablated and isolated using RBC. Dragging the balloon, contiguous lesions at the roof between the superior PVs were first created, then each antrum of all PVs were ablated, and finally, contiguous lesions at the PLA between the both inferior PVs were made, while we performed monitoring esophagus temperature and phrenic nerve pacing. Electro-anatomical bipolar voltage amplitude mapping (CARTO) of the LA-PVs was performed to determine the extent of this electrical isolation after all procedure. Successful isolation of the PLA including all PVs was achieved in all of 96 cases with elimination of all the PLA and PV potentials. The mean total procedure time 133 ± 31 minutes including 32±9 minutes fluoroscopy time. Recurrences of AF were diagnosed by Holter monitoring, mobile electrocardiogram. After first session, eighty- seven (59 paroxysmal, 28 persistent) of 96 patients were free from AF without anti-arrhythmic drugs and the remaining patients could maintain sinus rhythm with anti-arrhythmic drugs except two cases with LA flutter during 11.0±4.1 months follow-up. No major complications such as cerebral embolism, PV stenosis, or phrenic nerve palsy, and LA-esophageal fistula were observed. Complete isolation of the PLA including all PVs using a RBC, is useful for the treatment of both paroxysmal and persistent AF without severe complication.
Methods of detection of recurrence in patients with cutaneous melanoma
Authors: K. M. Dalal, K. S. Panageas, M. S. Brady, D. P. Jaques, D. G. Coit
Journal: Journal of Clinical Oncology (2006)

8057 Background: The patterns and methods of identification of initial recurrences of melanoma in patients staged with sentinel lymph node biopsy (SLNB) were studied. Methods: Stage I/II melanoma patients who underwent SLNB from 1991–2004 were identified from a prospective single-institution database. Detection of recurrence by self (awareness of symptoms or abnormal physical findings) or physician (discovered on routine physical exam or scheduled test) and timing of clinic visit were recorded. Postoperative followup included physical exam every 3–4 months for the first year, 3–6 months for the second, and 6–12 months thereafter. Serum LDH and CXR were obtained annually. CT and PET were performed on a selective basis. Results: Of 1062 patients who underwent SLNB, 211 patients (20%) experienced a total of 242 initial sites of recurrence. Recurrence was more common in SLN+ patients (47% vs. 14%; p&lt; 0.001, respectively). There were 198 patients evaluable for follow-up (median 35 months). Symptoms and self-detected physical findings were present in 109 patients (55.1%; table); 85 patients (42.9%) were seen earlier than their scheduled visit. Self-detected physical findings commonly identified in-transit (13%) and nodal (13%) disease. Physician detection occurred in 89 patients (44.9%); nearly half of these were detected by a scheduled radiographic test (CXR, n=14 [7%]; CT, n=26 [13%]; PET, n=1 [0.5%]). Detection of recurrence by an abnormal blood test was uncommon (n=2; 1%). Post-recurrence survival was associated with site of recurrence (table; p&lt;0.0001). In multivariate analysis, independent predictors of post-recurrence survival were site of recurrence and method of detection (p&lt;0.05). Conclusions: The most common site of recurrence following accurate nodal basin staging and management is systemic. Recurrent melanoma is self-detected by half of the patients. Systemic recurrence is detected by patient symptom or routine radiologic test, but it is associated with a less favorable outcome than recurrence detected by physical exam. [Table: see text] No significant financial relationships to disclose.
Your Germs and Mine: The Story of Good and Bad Microbes
Authors: Berl Ben Meÿr, J. D. Laudermilk
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5751: Aortic Valve Calcification is Prospectively Associated with Primary Cardiovascular Events Independent of Subclinical Coronary Artery Disease Severity: the Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: David S Owens, Matthew J Budoff, Khurram Nasir, Ronit Katz, Junichiro Takasu, J J Carr, David M Shavelle, Richard A Kronmal, Jeffrey L Probstfield, Kevin D O'Brien
Journal: Circulation (2008)

Calcific aortic valve disease is associated with increased cardiovascular (CV) morbidity and mortality in the elderly. It is unknown whether this association is independent of inflammation and subclinical coronary artery disease (CAD), or generalizable to a younger, healthier and more ethnically diverse cohort. Baseline risk factors and CT-determined aortic valve calcium (AVC) and coronary artery calcium (CAC) scores were assessed in 6,772 MESA participants (mean age 62 years; 53% female) free of CV disease at baseline. Multivariate Cox proportional hazards regression was performed using a pre-specified combined endpoint of fatal/non-fatal stroke, myocardial infarction, adjudicated CV death or resuscitated arrest (‘CVD event’). At baseline, 843 (12.5%) had prevalent AVC. Those with AVC had a higher prevalence of CAC (85% vs. 45%, p<0.001) and higher median CAC scores (205 vs. 69, p<0.001). Median follow up was 4.1 years, with 170 CVD events. Event rates were higher for the AVC vs. no AVC group (1.8% vs. 0...
Outlines in Health Education for Women.
Authors: Gertrude Bilhuber, Idabelle Post
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5584: Heart Failure Eliminates the Risk Gradient Defined by TIMI Risk Score in Non-st-segment Elevation Acute Coronary Syndromes
Authors: Sara S Gonçalves, Pedro Amador, Lígia Mendes, Filipe Seixo, José F Santos
Journal: Circulation (2008)

The TIMI Risk Score is a simple and effective tool for risk stratification in patients (pts) with non-ST-segment elevation acute coronary syndromes (NSTE-ACS). The presence of heart failure (HF) or a low ejection fraction (EF) has also been associated with a worse outcome. We sought to evaluate the interaction of heart failure on the risk gradient defined by the TIMI Risk Score in a NSTE-ACS population. We studied 9980 pts with NSTE-ACS included in a prospective nationwide clinical registry since 2002. Pts were stratified by TIMI Risk Score in low (0 to 2), intermediate (3 and 4) and high risk (5 to 7) groups. The population was divided in two groups according to the presence or absence of HF. HF was defined as the presence of a Killip class &gt;1 or a systolic EF &lt;30%. In-hospital mortality or re-infarction was assessed in both groups during the index hospitalization and according to TIMI Risk Score Stratification. Results: In-hospital mortality or re-infarction was 1,9% in low risk, 3,7% in intermediate and 6,3% in high risk pts (Qui-square trend p&lt;0,001). The risk gradient defined by the TIMI risk score was not observed in patients without HF (Qui-Square for trend=ns). In pts with HF, the TIMI risk score maintains its predictor value (Qui-square trend=0,014), but the presence of HF identifies a higher risk subgroup. In this population, HF was a strong independent predictor for in-hospital mortality and re-infarction (OR 10,01). In NSTE-ACS pts, the presence of HF identifies the patients with higher risk for in-hospital risk and re-infarction within each TIMI Risk Score subgroup. There was no risk gradient assessed by the TIMI risk score in the absence of HF.
Abstract 2017: A Single Bolus Intravenous Administration of Sodium Bicarbonate is Effective in the Prevention of Contrast-Induced Nephropathy in Patients with Renal Insufficiency Undergoing Diagnostic Coronary Arteriography or Elective Percutaneous Coronary Intervention
Authors: Akira Tamura, Kumie Miyamoto, Shigeru Naono, Yoshiyuki Kawano, Munenori Kotoku, Toru Watanabe, Junichi Kadota
Journal: Circulation (2008)

BACKGROUND: Recent prospective studies have demonstrated that intravenous hydration with sodium bicarbonate (SB) is effective in the prevention of contrast-induced nephropathy (CIN). However, it has not yet been invetigated whether a single bolus intravenous administration of SB immediately before exposure to contrast media can prevent CIN. Accordingly, this prospective, controlled, randomized trial was designed to examine the efficacy of a single bolus administration of SB in the prevention of CIN in patients with renal insufficiency undergoing diagnostic coronary arteriography (CAG) or elective percutaneous coronary intervention (PCI). METHODS: A total of 144 patients with a serum creatinine level of &gt;1.1 mg/dl and &lt;2.0 mg/dl scheduled for diagnostic CAG or elective PCI were enrolled in this study. The patients were randomly assigned to the following 2 groups: standard intravenous hydration with sodium chloride plus a single bolus intravenous administration of SB (20 ml = 20 mEq) 5 min before exposure of contrast media (group A, n = 72) and standard intravenous hydration with sodium chloride alone (group B, n = 72). The primary end point was the development of CIN, defined as an increase of ≥25% or ≥0.5mg in serum creatinine level within 3 days after the procedure. We also evaluated the incidence of adverse clinical events, including acute pulmonary edema, acute renal failure requiring dialysis, and death within the first 7 days after the procedure. RESULTS: There were no significant group differences in age, gender, the frequencies of diabetes mellitus and PCI, serum creatinine at baseline, the volume of contrast media, and drugs administered. The single bolus intravenous administration of SB led to a significant increase in arterial blood pH (7.41 ± 0.04 to 7.43 ± 0.03, p &lt;0.001). The incidence of primary end point was significantly lower in group A than in group B (1.4% vs 12.5%, p = 0.017). The incidence of adverse clinical events did not differ significantly between the 2 groups (0% vs 1.4%). CONCLUSIONS: A single bolus intravenous administration of SB before contrast injection is effective in the prevention of CIN in patients with renal insufficiency undergoing diagnostic CAG or elective PCI.
What’s new in the management of severe acute pancreatitis?
Authors: Yannick Mallédant, Manu L. N. G. Malbrain, Daniel A. Reuter
Journal: Intensive Care Medicine (2015)

Acute pancreatitis (AP) is a leading cause of hospitalization for gastrointestinal disorders [1]. Because of a substantially high mortality of up to 20–30 % in severe cases, early identification of patients who might require transfer to an intensive care unit (ICU) is essential [2].
William Henry Welch at Eighty: A Memorial Record of Celebrations Around the World in His Honor.
Authors: Victor Oscar Freeburg
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 279: Variables Associated with Successful Intubation Attempts Using Video Laryngoscopy: A Preliminary Report in a Helicopter Emergency Medical Service
Authors: Jestin N Carlson, Jorge Quintero, Francis X Guyette, Clifton W Callaway, James J Menegazzi
Journal: Circulation (2011)

Introduction: Multiple studies have demonstrated varying rates of successful endotracheal intubation (ETI) in the prehospital setting. Until the recent advent of video laryngoscopy, little information regarding the intubation process could be analyzed objectively by individuals other than the provider performing the ETI. We evaluated the association of variables recorded during video laryngoscopy and successful ETI attempts, defined as placing the endotracheal tube in the trachea. Methods: We retrospectively reviewed intubations performed by a single helicopter emergency medical service using a video larygoscope over an 8-month time period. Time intervals (e.g. attempt time) and intubation process variables (e.g. Cormack-Lehane view) were abstracted from all videos. We describe variables using means and standard deviations (continuous), medians with interquartile ranges (ordinal) and percentages (categorical). We examined the univariate associations between these variables and ETI success using logistic regression. Results: Results: We recorded 116 intubations during the study period. Twenty-nine recordings were either incomplete (n=26) or of insufficient quality for analysis (n=3). The remaining 87 videos represented 87 different patients with a total of 102 attempts at laryngoscopy. The first-pass success rate in this series was 76% (n=66) with 98% success within three attempts. Successful ETI attempts had lower entry to percentage of glottic opening (POGO) times (16.6 sec vs. 32.1 sec, p=0.013), entry to tube times (17.6 sec vs. 27.4 sec, p=0.04), higher POGO scores (76 vs. 39, p&lt;0.001) and lower Cormack-Lahane views (1 vs. 3, p&lt;0.001). Recognized esophageal intubation was more likely to occur during unsuccessful ETI attempts (43% vs. 8%, p&lt;0.001). Conclusion: Video laryngoscopy provides a variety of time interval and intubation process variables regarding ETI that can be abstracted. Successful ETI attempts have significantly shorter entry to POGO times, entry to tube times, obtain better views of the glottic opening (POGO and C-L views) and a lower incidence of recognized esophageal intubation.
Dictionary of Bacteriological Equivalents — French-English; German-English; Italian-English; Spanish-English.
Authors: William Partridge
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The need for a national body for research misconduct
Authors: R. Smith
Journal: BMJ (1998)

News p 1695 Education and debate p 1726 Personal view p 1755 

The British medical research community is busy assembling its response to research misconduct. The question is no longer, “Do we have a problem?” but rather, “How can we best respond?” The BMJ has thus commissioned five answers to the question (p 1726),1 two from people outside Britain with extensive experience of research misconduct. One recurrent theme is that Britain needs a central body to lead on this difficult issue.

The answers are published in a week when we have to retract yet another article because of probable fraud (p 1700).2 One of the authors of the retracted paper was recently struck off by the General Medical Council for research misconduct. 3 4 He had also lied about his qualifications. Cameron Bowie, his coauthor, then started from the inevitable assumption that all of the rest of his work was fraudulent until proved otherwise and found that he could not satisfy himself that his coauthor had completed the work he said he had. Bowie describes his miserable experience in a personal view and has retracted a paper that has …
Limitation of over the counter sales of paracetamol
Authors: M. Cranney, J. Cranney, H. Stubbs, N. I Jowett
Journal: BMJ (1998)

Costings were inadequateEditor-Comparing the costs of home and acute hospital care, Coast et al address a subject of intense interest to NHS managers. 1The cost of home care in their study was based on a bottom up analysis, in which use of resources was measured on a patient by patient basis.The cost of hospital care, however, was simply the average cost of inpatient care, which includes the use of operating theatres, etc. Patients for whom both sources of care are a viable option, however, are at the lower end of the intensity range for hospital care.The authors recognise this but address the problem by conducting a sensitivity analysis.They imply that assuming a
Genome-wide association study of kidney function decline in individuals of European descent: the CKDGen Consortium.
Authors: M. Gorski, A. Tin, M. Garnaas, G. M. McMahon, A. Y. Chu, B. O. Tayo, C. Pattaro, A. Teumer, D. I. Chasman, J. Chalmers, P. Hamet, J. Tremblay, Mark Woodward, T. Aspelund, G. Eiriksdottir, V. Gudnason, T. B. Harris, L. J. Launer, A. V. Smith, B. D. Mitchell, J. R. O'Connell, A. R. Shuldiner, J. Coresh, M. Li, P. Freudenberger, E. Hofer, H. Schmidt, R. Schmidt, E. G. Holliday, P. Mitchell, J. J. Wang, I. H. de Boer, G. Li, D. S. Siscovick, Z. Kutalik, T. Corre, P. Vollenweider, G. Waeber, J. Gupta, P. A. Kanetsky, S. J. Hwang, M. Olden, Q. Yang, M. de Andrade, E. J. Atkinson, S. L. Kardia, S. T. Turner, J. M. Stafford, J. Ding, Y. Liu, C. Barlassina, D. Cusi, E. Salvi, J. A. Staessen, P. M. Ridker, H. Grallert, C. Meisinger, M. Muller-Nurasyid, B. K. Kramer, H. Kramer, S. E. Rosas, I. M. Nolte, B. W. Penninx, H. Snieder, M. Fabiola Del Greco, A. Franke, U. Nothlings, W. Lieb, S. J. Bakker, R. T. Gansevoort, P. van der Harst, A. Dehghan, O. H. Franco, A. Hofman, F. Rivadeneira, S. Sedaghat, A. G. Uitterlinden, S. Coassin, M. Haun, B. Kollerits, F. Kronenberg, B. Paulweber, N. Aumann, K. Endlich, M. Pietzner, U. Volker, R. Rettig, V. Chouraki, C. Helmer, J. C. Lambert, M. Metzger, B. Stengel, T. Lehtimaki, L. P. Lyytikainen, O. Raitakari, A. Johnson, A. Parsa, M. Bochud, I. M. Heid, W. Goessling, A. Kottgen, W. H. Kao, C. S. Fox, C. A. Boger
Journal: Kidney International (2015)
Abstract 17502: Mechanical Stimulus is Coupled to Aberrant Angiogenesis in Pulmonary Artery Smooth Muscle Cells Following Superior Cavopulmonary Connection
Authors: Minoo N Kavarana, Adam W Akerman, Risha K Patel, Shaina R Eckhouse, Jason B Wheeler, Jefrey A Jones, John S Ikonomidis, Rupak Mukherjee
Journal: Circulation (2013)

Background: The Glenn shunt, or superior cavopulmonary connection (SCPC), connects the superior vena cava to either the right pulmonary artery (RPA) or both pulmonary arteries as a means to reduce ...