tbuckley/cabot-search huggingface dataset:
Call to needle times after acute myocardial infarction
Authors: D. A Sandler, P D Thomas, J. Rawles
Journal: BMJ (1999)

Surgical techniques should be fully evaluatedEditor-The editorial by Nicholson and Bradley on renal transplantation from living donors rightly pointed out that the United Kingdom has a lower rate of transplantations which use kidneys from living donors than the United States or Norway. 1 The recent report by the Royal College of Surgeons on organ transplantation in the United Kingdom recommended that steps should be taken to increase the use of kidneys from living donors in the United Kingdom to offset the shortage of cadaveric kidneys as well as to improve outcome. 2 In the United Kingdom in 1998, 38% more transplantations were performed using organs from living donors than in 1997.However, there is still some way to go if a level similar to that of the United States or Scandinavia (25-30%) is to be achieved.Nicholson and Bradley identify the risks associated with donor nephrectomy and state that much of the morbidity that occurs after open nephrectomy is related to the wound.For this reason they believe that the use of laparoscopically assisted donor nephrectomy needs to be examined in the light of the experience of, for example, the Johns Hopkins Hospital in Baltimore, Maryland.However, there have been no randomised prospective trials of this procedure, which takes longer than open nephrectomy.Furthermore, all of the non-randomised comparisons have been of open nephrectomy performed through a loin incision, with or without removal of a rib.If an anterior
Characterization of gene specific methylation in pheochromocyotmas/abdominal paragangliomas: Correlation with malignant behavior
Authors: Janos Geli, Nimrod Kiss, Mohsen Karimi, Jia-Jing Lee, Martin Backdahl, Tomas Eckstrom, Catharina Larsson
Journal: Clinical Cancer Research (2007)

AACR Centennial Conference: Translational Cancer Medicine-- Nov 4-8, 2007; Singapore

B68 

Purpose: To quantitatively assess promoter methylation changes in pheochromocytomas and abdominal paragangliomas and its relation to clinico-pathological features.    Experimental design: A panel of 53 primary tumors (42 benign, 11 malignant) was analysed by quantitative bisulfite Pyrosequencing. Based on methylation levels in the tumor suppressor genes, p16INK4A, CDH1, DCR2, RARB, RASSF1A, NORE1A, TP73, APC, DAPK1, p14ARF and PTEN, a CpG island methylator phenotype (CIMP) was defined as concerted hypermethylation in three or more genes. Mean Z-scores for the hypermethylated promoters were calculated to characterize overall promoter methylation.    Results: Five primary tumors (9.4%) exhibited a CIMP phenotype, four of which were malignant paragangliomas. CIMP was significantly associated with malignant behavior (p = 0.005), and younger age at presentation (p<0.007)    Conclusion: We here describe the identification of CIMP in abdominal paragangliomas and a strong association of this phenotype with malignant behavior as well as young age at presentation. The findings raise a prospective for potential benefits of epigenetically acting drugs for a subgroup of young abdominal paraganglioma patients with adverse prognosis.
The effect of liposome inhalation on non-invasive oxidative stress markers in patients with bronchial asthma
Authors: Alexander Lisitsa, Igor Klimanov, Svetlana Soodaeva
Journal: European Respiratory Journal (2011)

Background: The liposome inhalation demonstrates an antioxidant activity in the treatment of various diseases, confirmed both by experimental and clinical studies.

The aim is to carry out a prospective study of antioxidant features of liposome admission in patients with the exacerbation of bronchial asthma.

Materials and methods: We enrolled 50 patients (age=37±7.5 year, men=64%) with mild-to-moderate bronchial asthma (FEV1>70%, steroid-naive) in prospective comparison study. All patients were divided in two groups: group 1 contains 25 patients, who received a liposome inhalation by compression nebulizer once a day (300 mg of phospholipids in each admission); group 2 contains 25 patients, who received a traditional therapy (control). Antioxidant activity was determined by the estimation of the exhaled nitric oxide level (ENO) and total nitrite/nitrate (TNN) in exhaled breath condensate before and after the investigation period.

Results: There was a significant decrease of ENO level in group 1 from 31.8±2.4 to 7.1±1.4 ppb (p<0.001) after the observing period. In group 2 the ENO level was decreased from 29.7±3.9 ppb to 25.0±2.5 ppb (not significant). Patients in both groups had significantly higher levels of TNN before the study (7.9±0.9 μ M and 8.4±1.1μM respetively). After liposome admission the TNN level in group 1 decreased to 0.9±0.1 μ M (p<0.01) as well as in control group it was at the same border (7.7±1.4 μM).

Conclusion: The results obtained demonstrate that liposome inhalation administered once a day during 14-days period has a significant antioxidant effect in patients with mild-to-moderate bronchial asthma.
Effects of Bariatric Surgery on Cardiac Ectopic Fat
Authors: Bénédicte Gaborit, Alexis Jacquier, Frank Kober, Ines Abdesselam, Thomas Cuisset, Sandrine Boullu-Ciocca, Olivier Emungania, Marie-Christine Alessi, Karine Clément, Monique Bernard, Anne Dutour
Journal: Journal of the American College of Cardiology (2012)
Abstract 14696: Carotid Augmentation Index is related to Coronary Plaque Morphology in Patients with Coronary Artery Disease: An Optical Coherence Tomography Study
Authors: Masato Mizukoshi, Toshio Imanishi, Hironori Kitabata, Yasushi Ino, Takashi Tanimoto, Kenichi Komukai, Kohei Ishibashi, Keizo Kimura, Keisuke Satogami, Hideyuki Ikejima, Manabu Kashiwagi, Hiroto Tsujioka, Yuichi Ozaki, Makoto Orii, Yasutsugu Shiono, Kunihiro Shimamura, Keishi Okochi, Aiko Shimokado, Tsuyoshi Nishiguchi, Naoki Maniwa, Risa Imamura, Masahiro Takahata, Yoshihiro Nakatani, Teruaki Wada, Hiromichi Sougawa, Nozomi Wada, Tomizo Masuno, Ikuko Teraguchi, Yong Liu, Kazushi Takemoto, Kumiko Hirata, Takashi Kubo, Takashi Akasaka
Journal: Circulation (2010)

Background: The augmentation index (AI) has been considered to reflect vascular property and predict a higher risk of coronary atherosclerosis. However, the association of augmentation index and coronary plaque morphology has not been fully elucidated.Optical coherence tomography (OCT) is a high-resolution imaging modality and allows us to analyze the plaque morphology in detail. In this study, we observed the coronary plaque morphology by OCT at the coronary culprit artery in patients with coronary artery disease (CAD) and evaluated the association of augmentation index and coronary plaque characteristics. Methods: The measurement of AI by carotid ultrasound and OCT examinations were performed in 33 patients with CAD (stable angina pectoris (SAP): n=19, acute coronary syndrome (ACS): n=14). At the coronary culprit artery, plaque characterization (lipid or fibrous plaque) was analyzed. Futhermore, fibrous cap thickness, spotty calcification, thin cap fibroatheroma (TCFA), and plaque rupture were noted as ...
High-Dose Chemotherapy and Autologous Stem Cell Transplantation In Patients With High-Risk Neuroblastoma : Results Of Turkish Pediatric Oncology Group- Neuroblastoma 2003 (TPOG-NBL 2003) Protocol
Authors: Serap Aksoylar, Ali Varan, Canan Vergin, Volkan Hazar, Ferhan Akici, Ayhan Dagdeviren, Emel Unal, Haldun Oniz, Sema Anak, Vedat Koseoglu, Dilek Ince, Nur Olgun
Journal: Blood (2013)
Abstract 13995: Glycosylated Hemoglobin is a Predictor of Adverse Cardiac Events After Coronary Stent Implantation Among Patients Without Diabetes Mellitus
Authors: Gabor Voros, Mark Coosemans, Tom Adriaenssens, Walter Desmet, Christophe Dubois, Peter Sinnaeve
Journal: Circulation (2011)

The effect of glucose homeostasis and metabolic hormones on the outcome after percutaneous coronary interventions is controversial and has not been extensively investigated in non-diabetic patients...
Abstract 61: Effect of Gender on Outcome of Out of Hospital Cardiac Arrest in the Resuscitation Outcomes Consortium
Authors: Valeria E Rac, Robert H Schmicker, Myron L Weisfeldt, Blair L Bigham, Robert A Berg, Alexis Topjian, Beth Abramson, Dianne L Atkins, Laurie J Morrison, Roc Investigators
Journal: Circulation (2010)

Introduction:  Over the last two decades many studies have reported that certain medical conditions/diseases have innate gender-based predominance due to specific hormonal regulation. Women are likely to have unfavorable outcomes in cardiac arrest with significantly lower unadjusted survival rates than men This study examined the relationship between gender and outcome of non-traumatic out of hospital cardiac arrest (OHCA).   Hypothesis:  Gender is associated with the outcome of non-traumatic OHCA.   Methods:  All non-traumatic EMS treated OHCA patients in the Resuscitation Outcomes Consortium between December 2005 and May 2007 prior to launching of ROC PRIMED RCT were included. Patient age was analyzed as a continuous variable. To further separate the groups by hormonal status patients were stratified in the two age cohorts: 15–45 and >55 years of age (yo). Unadjusted chi square tests and logistic regression models were employed to examine the relationship between gender, age and survival outcomes.   Results:  This study enrolled 14633 patients; 63.6% were male with a mean age of 64.2 and 36.4% were female with a mean age of 68.3. Women survived to hospital discharge less often then men (6.4% vs. 9.1%, p 55yo) was lower compared to men (5.5% vs. 8.4%, p 55 cohort (p=0.57, OR: 0.94, 95%CI: 0.78, 1.15).   Conclusions:  Survival rates to hospital discharge of OHCA differ between men and women, but this difference appears to be confounded by several Utstein factors. Age modifies the association of gender; a result that supports a protective hormonal effect among premenopausal women.
P0661 : Prediction of HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients treated with entecavir using ALT and platelet count: Results from a large european multi-center study
Authors: H. Chi, F. van Bömmel, M. Buti, A. Brown, I. Carey, M. Fasano, D. Mutimer, K. Deterding, Y. Oo, P. Arends, R.J. de Knegt, T. Santantonio, T.M. Welzel, P. Pradat, J. Petersen, H. Wedemeyer, T. Berg, F. Zoulim, B.E. Hansen, H.L Janssen
Journal: Journal of Hepatology (2015)
二甲双胍长期治疗2型糖尿病患者以及维生素B12缺乏的危险性：随机安慰剂对照研究（摘要）
Authors: Jolien, Jager, Adriaan, Kooy, Philippe, Lehert, Michiel, Wulffele, Jan, van, der, Kolk, Daniel, Bets, Verburg, Donker, Coen, Stehouwer, 许翎岭
Journal: BMJ (2010)

目的 研究接受胰岛素治疗的2型糖尿病患者中，二甲双胍所致维生素B12缺乏（〈150pmol／L）、低浓度维生素B12（150—220pmol／L）的发生率，以及叶酸和同型半胱氨酸的浓度。
Changes in Follow-Up Left Ventricular Ejection Fraction Associated With Outcomes in Primary Prevention Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Device Recipients
Authors: Yiyi Zhang, Eliseo Guallar, Elena Blasco-Colmenares, Barbara Butcher, Sanaz Norgard, Victor Nauffal, Joseph E. Marine, Zayd Eldadah, Timm Dickfeld, Kenneth A. Ellenbogen, Gordon F. Tomaselli, Alan Cheng
Journal: Journal of the American College of Cardiology (2015)
Bovine spongiform encephalopathy is being maintained by vertical and horizontal transmission
Authors: R W Lacey
Journal: BMJ (1996)

Magnetic resonance imaging may have a role in diagnosing Creutzfeldt-Jakob disease EDITOR,-Creutzfeldt-Jakob disease' is still rarely diagnosed in Britain, and neuropathological examination is required to confirm the diagnosis.Research in the United States, however, has shown the presence of bilaterally symmetric hyperintense abnormalities in the basal ganglia in T2 weighted magnetic resonance images in patients with pathologically proved Creutzfeldt-Jakob disease.2This abnormality on magnetic resonance imaging was first reported in 1988.3A colleague and I have reported Creutzfeldt-Jakob disease, with signal abnormalities in the basal ganglia on magnetic resonance imaging, in a 58 year old man with no occupational exposure to animals who presented with progressive dementia.4The prevalence of hyperintense abnormalities in the basal ganglia in T2 weighted images in patients with Creutzfeldt-Jakob disease has not been studied and remains unknown.Such hyperintense abnormalities in the basal ganglia can be seen in several disorders, but a combination of clinical features, laboratory findings, and imaging characteristics can be used to distinguish the other conditions from Creutzfeldt-Jakob disease.Although the absence of bilateral symmetric hyperintense lesions in the basal ganglia does not exclude Creutzfeldt-Jakob disease, it is reasonable to assume that their presence in patients with rapidly progressive dementia is a specific sign of the disease.It would be useful to know of other documented cases in which magnetic resonance imaging was carried out before death.Surely it would be worth while pursuing further research in this field and collating data from several centres with an interest in Creutzfeldt-Jakob disease to evaluate the role of magnetic resonance imaging in this condition.
Increase in reported gonorrhoea cases in Sweden, 2001 - 2008
Authors: I Velicko, M Unemo
Journal: Eurosurveillance (2009)

Gonorrhoea is on the rise in Sweden and in many other European countries. The present report describes and evaluates the gonorrhoea trends in Sweden from 2001 to 2008 when an increase of 32% was reported. Up to 86% of the cases were reported in men, with the highest proportion among heterosexually infected men (41-59% during these years). Heterosexually infected men more often acquired gonorrhoea abroad, especially in Thailand, whereas women and men who have sex with men were more likely to acquire the infection within Sweden. The recent increase in gonorrhoea cases in Sweden is most likely due to adoption of more risky sexual behaviour (e.g. an increase in the number of sexual partners and the number of new/casual sexual partners and/or low use of condoms) in the Swedish population. Further research regarding more effective identification and description of sexual transmission chains and sexual networks is needed in order to follow the spread of infection and to recognise more effective interventions to prevent the spread of gonorrhoea and also other sexually transmitted infections.
Abstract 9193: Clinical Characteristics and Outcomes of Centenarians with Acute Myocardial Infarction
Authors: Nora M Cosgrove, Abel E Moreyra, Alan C Wilson, Yu-Hsuan Shao, William J Kostis, John B Kostis
Journal: Circulation (2010)

Introduction: The number of persons living beyond the age of 100 is increasing. Coronary artery disease remains an important cause of morbidity and mortality in this age group. Methods: We used the...
Abstract 3879: Predictor of Occurrence of Congestive Heart Failure and Upgrade to Cardiac Resynchronisation Therapy Device in Patients With Cardiac Sarcoidosis Implanted Pacemaker and Implantable Cardioverter-Defibrillator
Authors: Koki Nakamura, Koji Kumagai, Naoki Takemura, Estuko Fuke, Chizuru Sato, Tatsuya Hayashi, Yuko Miki, Koji Goto, Jotaro Iwamoto, Rie Fukasawa, Marehiko Ueda, Nobusada Funabashi, Shigeto Naito, Shigeru Oshima, Koichi Taniguchi, Issei Komuro
Journal: Circulation (2009)
Abstract 2063: Longitudinal Follow-up Of Cognitive Function After Cardiac Valve Replacement: A Three-Year Prospective Study
Authors: Stephan C Knipp, Sylvia Uslar, Matthias Thielmann, Nadine Matatko, Marc Schlamann, Michael Forsting, Hans C Diener, Heinz Jakob
Journal: Circulation (2007)

Background: Adverse neurocognitive outcome has been a continuing challenge to modern cardiac surgery. Cardiac valve replacement implies a high risk of neuronal injury. However, long-term studies of cognitive function do not exist until now. We aimed to assess the course of cognitive performance during 3 years after cardiac valve surgery and to identify factors that may predict long-term outcome. Methods: A total of 30 patients (64.9±9.8 yrs.) undergoing elective isolated heart valve replacement as the first time cardiac operation were prospectively investigated preoperatively, at discharge, 3 months and 3 years after surgery. Neuropsychological performance was evaluated with a battery of 11 standardized psychometric tests measuring seven cognitive domains (psychomotor speed, executive function, attention, verbal memory, visual memory, logical thinking, visuoconstruction). High-resolution multi-sequence magnetic resonance imaging (MRI) including diffusion-weighted technique was performed to detect cerebral ischemia. Results: Cognitive deficits (drop of ≥1 standard deviation in scores in ≥3 tests) were present in 15/30 patients (50%) at discharge, 2/30 patients (7%) at 3 months, and 4/25 patients (16%) at 3 years compared to baseline, respectively. Both patients with a deficit at 3 months behaved normal at discharge, and none of the patients had a persistent deficit. Postoperative MRI disclosed 41 new focal ischemic brain lesions in 47% of patients (1–7 lesions/patient; lesion volume 91–745 mm 3 ). All lesions were neurologically silent. None of the variables tested by stepwise regression analyses including medical history data, operative factors, preexisting or new postoperative ischemic lesions on MRI, postoperative adverse events or type of prosthesis were found to predict late cognitive decline. Conclusions: Cognitive decline after cardiac valve replacement is benign and frequently resolves within weeks. The few cognitive deficits that were found years later are most likely related to factors other than the operation itself.
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
Authors: Lu Jiang, Zhao-Hui Gu, Zi-Xun Yan, Xia Zhao, Yin-Yin Xie, Zi-Guan Zhang, Chun-Ming Pan, Yuan Hu, Chang-Ping Cai, Ying Dong, Jin-Yan Huang, Li Wang, Yang Shen, Guoyu Meng, Jian-Feng Zhou, Jian-Da Hu, Jin-Fen Wang, Yuan-Hua Liu, Lin-Hua Yang, Feng Zhang, Jian-Min Wang, Zhao Wang, Zhi-Gang Peng, Fang-Yuan Chen, Zi-Min Sun, Hao Ding, Ju-Mei Shi, Jian Hou, Jin-Song Yan, Jing-Yi Shi, Lan Xu, Yang Li, Jing Lu, Zhong Zheng, Wen Xue, Wei-Li Zhao, Zhu Chen, Sai-Juan Chen
Journal: Nature Genetics (2015)
Phase 1 Study of the Investigational Proteasome Inhibitor Ixazomib Alone or in Combination with Lenalidomide–Dexamethasone (Rd) in Japanese Patients (Pts) with Relapsed and/or Refractory Multiple Myeloma (RRMM)
Authors: Hiroshi Handa, Kenshi Suzuki, Takaaki Chou, Takafumi Matsushima
Journal: Blood (2014)
Abstract 15601: Left Atrial Function Before and Following Restrictive Annuloplasty for Ischemic Mitral Regurgitation Evaluated by Two-Dimensional Speckle Tracking Echocardiography
Authors: Leen van Garsse, Sandro Gelsomino, Emile Cheriex, Fabiana Luca, Carmelo Massimiliano Rao, Roberto Lorusso, Gian Franco Gensini, Jos G Maessen
Journal: Circulation (2011)

Background:  We evaluated left atrial (LA) function before and after restrictive annuloplasty (RA) for chronic ischemic mitral regurgitation (CIMR) with two-dimensional speckle-tracking echocardiography (2D-STE).   Methods and Results:  In 152 CIMR patients (mean age 65.9±7.1 yrs) undergoing RA, LA function was evaluated preoperatively and at follow up (median 41.5 months [IQR23-61]. LA global strain (e) was calculated as the average of longitudinal strain in 12 LA segments at the end of left ventricle (LV) ejection (LA reservoir). We measured peak strain rate (SR P ) during LV ejection (LA reservoir), early diastolic strain rate (SR D ) during LV early diastole (LA conduit) and peak negative strain rate (SR N ) after the P-wave (LA contraction).Twenty age- and gender-matched healthy adults were controls. LA empting fraction (LA EF ) was used as index of atrial compliance. Early diastolic annular velocity (Em) was obtained by pulse tissue Doppler and the E/Em ratio was used as index of LV filling pressure. At follow up, 34 patients had recurrent MR≥ 2+ (Group 1), whereas 118 did not (Group 2). Baseline e and SRp were significantly higher in Group 2 compared to controls (44.2 ± 16.2 and 1.62 ± 0.7 vs.35.5 ± 14.1 and SR P , 1.54 ± 0.5, both p D  and SR N  (1.23 ± 0.2 and SR N  −1.39 ± 0.3) were significantly different from Group 2 (1.81 ± 0.8 and −1.89 ± 0.9, p EF  was lower (42 ± 11% vs.71 ± 14%, p P  (1.56 ± 0.5, p=0.01), SR D  (1.78 ± 0.7, p=0.04)) and SR N (−1.79 ± 0.7, p=0.03) normalized whereas these indices did not change in Group 1 (e, 32.6 ± 12.9[p=0.8]; SR P ,1.37 ± 0.3[p=0.5]; SR D 1.20 ± 0.2[p=0.9]; SR N  (-1.30 ± 0.2[p=0.07]). Finally, E/Em was still higher in Group 1 (8.5 ± 2.6 vs. 6.9 ± 3.0, p=0.006) whereas LA EF  remained lower (40 ± 10% vs.70 ± 13%, p   Conclusions:  In patients with recurrent MR we observed an irreversible impairment of the LA reservoir due to reduced compliance. The filling and contraction did not improve after operation and this might be attributable to high LV filling pressure and increased afterload.
Abstract 5602: Initial Angle and Overcorrected Angle at Coronary Lesion Predicts Delayed Drug-Eluting Stent Fracture: Quantitative Angle Analysis in Stent Fracture Patients
Authors: Kyung-Kuk Hwang, Jang-Whan Bae, Won-Yik Lee, Dong-Woon Kim, Myeong-Chan Cho
Journal: Circulation (2008)

Background : Stent fracture (SF) is a potential cause of restenosis, pseudoaneurysm or thrombosis, which acquire special significance in the treatment failure with drug-eluting stent (DES). From a point of view that chronic fatigue stress associated with anlge and angular momentum, we quantitatively analyzed the initial native maximum and minimum angles (Ai-max, Ai-min) and the change (ΔAi) in repetitive bending movement of coronary lesion before stenting, angles (Ap-max, Ap-min, ΔAp) after immediate stenting, corrected angle [A corr-max=Δ (Ap−Ai) max] by stent, and angles (Asf-max, Asf-min, ΔAsf) after SF in delayed DES fracture patients. Methods : From October 2005 to July 2006, 139 patients underwent follow-up coronary angiography after 258 DES implantations. DES fractures were detected at 13 patients (M:F=12:1, Age: 60.3±9.4 year-old). We quantitatively analyzed the angles (Ai, Ap, ΔA, Asf) at the same plane view by Nexus 1.0 in 13 patients. Results : The follow-up duration was 255.7±75.7 days. All 13 DES fractured patients had no clinical symptoms associated with SF, and had a male-predominance. The number of stent implantation at target lesion associated fracture site was 1.9±0.6. Stent diameter and length were 3.00±0.25 and 53.0±17.4 mm. Four of 13 patients had multiple fractures (LAD; 2, RCA: 2 cases). Nine patients had single fracture (LAD; 1, LCX; 3, RCA; 5 cases). All most all fracture sites (92.3%, 12/13cases) were angulated and bending lesion. Only 1 fracture site was not associated with angulated lesion. The mean ΔAi, Ai-max and Ai-min were 18.9°, 145.5° and 125.8°. Mean ΔAp, Ap-max and Ap-min were 4.9°, 158.8° and 154.1°. Mean maximal corrected angle by PCI were 28.3°. In SF, The mean ΔAsf, Asf-max and Asf-min were 13.8°, 149.4° and 133.5°. These Asf values had a strong tendency to recover the initial native physiologic angle (Ai) against corrected angle by stenting. The simulation program for evaluation of angular momentum in DES supports the same results. Conclusion : Theses findings suggest that the initial angle and extent of overcorrected angle against physiologic coronary configuration are important at delayed DES fracture. And it has considering potential as a new marker for assessing risk of DES fracture.