tbuckley/cabot-search huggingface dataset:
Can Somatic Stem Cells Regenerate Myocardial Tissue?
Authors: Marie Jose Goumans, Anke Smits, Piet van Vliet, Simone Post, Rutger J. Hassink, Pieter Stella, Pieter A. Doevendans
Journal: Cardiovascular Research (2006)

Somatic stem cells can be obtained from various sources and their differentiation potential is not restricted only to the differentiated cell phenotypes of the source tissue. Therefore, somatic stem cells offer a great promise for cell replacement therapy in diseased hearts. Yet, much confusion has been created concerning the use of somatic stem cells. Different methods have been used to isolate and recognize stem cells, and the nomenclature is not standardized and often based on the method of cell isolation, making it difficult to compare the different studies. In humans the situation is worse as the scientific approach to the stem cell issue is overtaken by clinical applications of somatic stem cells or approaches to mobilize endogenous stem cells. Here we discuss the current knowledge on somatic stem cells in animal models and humans. In addition, the solid proof for beneficial effects of stem cell mobilization is critically reviewed and finally the question whether cardiomyoblasts exist is addressed. This chapter is written to provide clarity on different classifications of somatic stem cells and to raise hypothesis for future research.
Mitomycin C (MMC) in the treatment of non-small cell lung cancer (NSCLC): a meta-analysis with qualitative assessment.
Authors: Thierry Berghmans, Lidia Ghisdal, Marianne Paesmans, Fabrice Branle, Jean-Jacques Lafitte, Frédéric Vallot, Anne-Pascale Meert, Emmanuelle Steels, Agnès Burniat, Céline Mascaux, Jean-Paul Sculier
Journal: European Respiratory Journal (2000)
Abstract 3157: Depletion of Circulating Endothelial Progenitor Cells and Endothelial Dysfunction in Subjects with Depressive Symptoms
Authors: Hua Chen, Jianati Qiuwaxi, Ching-Yuen Wong, Sheung-Wai Li, Hiu-Ting Chan, Sidney Tam, Chu-Pak Lau, Hung-Fat Tse
Journal: Circulation (2008)

Introduction: Although the mechanisms remain unclear, depression is associated with endothelial dysfunction and increases risk of cardiovascular disease (CVD). Recent studies suggest that circulating endothelial progenitor cells (EPC) play an important role in endothelial repair and correlate with endothelial function. Hypothesis: We assessed the hypothesis that the presence of depressive symptoms in subjects without significant CVD is associated with depletion of circulating EPC and impaired endothelial function. Methods: We studied the relationship between the level of circulating EPCs, endothelial function and depression status in 129 healthy normal individuals (54±10 yrs, 54 men) without prior CVD or diabetes. The numbers of circulating CD34/KDR + EPCs were determined by flow cytometry, and the depression status was estimated by Depression Anxiety Stress Scales. Brachial artery flow-mediated dilation (FMD) was measured by high-resolution vascular ultrasound imaging. Results: The median depression score of the study population was 4 (range 0 to 34), and 41 subjects (32 %) had high depression score (DS) ≥8 (defined by ≥ the 75th percentile of the depression score). There were no significant differences in baseline clinical characteristics between subjects with or without high DS (all P &gt; 0.05 ). However, subjects with high DS had significantly lower FMD (5.4±2.7 vs. 8.0±4.0 %, P &lt; 0.001 ) and CD34/KDR + EPC% (1.24±1.27 vs. 2.02±2.43 %, P = 0.037 ) than those with normal DS. Multivariate regression analysis revealed that a high DS (OR 1.08, 95%CI: 1.02–1.15, P = 0.009 ) and old age (OR 1.05, 95%CI: 1.01–1.09, P = 0.029 ) were independent predictors for decreased FMD. Conclusions: The results of this study demonstrated that in subjects without significant CVD, the presence of a high DS was associated with impaired brachial FMD and depletion of circulating EPC. Nevertheless, only depression score, but not the percentage of circulating EPC significantly correlated brachial FMD, and was an independent predictor for impaired brachial FMD.
bmjlearning.com: Occupational asthma
Authors: Kieran Walsh
Journal: BMJ (2004)

Occupational asthma is the most common form of occupational lung disease in developed countries. As more new chemicals are produced, people will become exposed to more respiratory sensitisers and irritants. About 10% of patients with adult onset asthma have occupational asthma, and it can affect not only their health and quality of life but also their jobs and finances. For these reasons, you should always consider the diagnosis in people who develop asthma as adults. Since the prognosis is related to the duration of the exposure, it is important to diagnose and treat patients promptly.

Many myths about occupational asthma persist despite being disproved by evidence. For example, not all patients feel better when they take a weekend off work: many patients require 7-10 days for symptoms to resolve. And you don't need to tell patients to stay away from work while the diagnosis is being considered unless they are very ill.

To find out more myths and facts on occupational asthma, try BMJ Learning's new module on bmjlearning.com. Our interactive learning website offers online resources to train and test your skills in a variety of clinical and non-clinical topics.
The Extra-Ocular Muscles: A Clinical Study of Normal and Abnormal Ocular Motility
Authors: H. E. MacDermot
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parathyroid Hormone in Human Plasma
Authors: Gino V. Segre, Joel F. Habener, David Powell, Geoffrey W. Tregear, John T. Potts
Journal: Journal of Clinical Investigation (1972)

Antigenic recognition of four anti-bovine parathyroid hormone antisera was characterized by their reactivity with bovine hormonal fragments (1-34, 1-13, 14-34, 19-34, 53-84) and human hormone extracted from parathyroid adenomas. All antisera were found to have antibody populations which recognized more than one antigenic determinant and all antisera differed in their specificity and reactivity for the fragments of bovine hormone. By modification of two antisera, GP-1 and GP-133, by preincubation with excess concentrations of 1-34 or 53-84 fragments, antigenic recognition was restricted to defined regions of the hormonal sequence.
Abstract 18184: Deficiency in the Novel Small Leucin-Rich Repeat Protein Podocan Promotes Pressure Load-Induced Cardiac Hypertrophy
Authors: Walter SSpeidl, LincolnShenje, Juan JBadimon, David JSchneider, PaulKlotman, RandolphHutter
Journal: Circulation (2013)

Background: Extracellular matrix (ECM) molecules have been increasingly implicated in cardiac remodeling, and in particular the myocardial response to pressure overload. Podocan is a novel member of the small leucin-rich-repeat protein family of ECM proteins. We recently have characterized podocan as an inhibitor of the migration and proliferation of vascular smooth muscle cells. Now we are testing if podocan deficiency has an effect on pressure load-induced cardiac hypertrophy. Methods and Results: We induced pressure overload cardiac hypertrophy using aortic banding (AB) in mice (age 10-12 weeks) with podocan-/- (n=6) and wild-type (WT) (n=7) genotype. Four weeks after AB, cardiac anatomy and function were assessed by echocardiography. In addition, histological analysis was used to assess the myocardial response to AB. Podocan-deficient mice showed significantly greater cardiac hypertrophy compared with WT mice after AB, whereas no significant differences were observed when comparing sham-operated anima...
Abstract 10705: Elevated Levels of Hepatocyte Growth Factor and Interleukin-6 Distinguish Cardiac Amyloid From Non-Ischemic Cardiomyopathy as a Cause of Heart Failure
Authors: Evan L Brittain, Quinn S Wells, Jared P LeBoeuf, Yan R Su, Jesalyn A Tate, Mary E Keebler, Daniel J Lenihan
Journal: Circulation (2011)
Identification of Microrna (MIRNA) Signatures for Response and Survival in Non-Small Cell Lung Cancer (NSCLC) Patients (PTS) Treated with Cisplatin-Vinorelbine (CV): A ELCWP Study
Authors: I. Cstoth, T. Berghmans, L. Willems, M. Paesmans, L. Ameye, J. Lafitte, A. Scherpereel, A. Cortot, C. Mascaux, J. Sculier
Journal: Annals of Oncology (2012)
Abstract 1459: Tbx5 Regulates Progenitor Cell Migration During Cardiac Vasculogenesis
Authors: Diman Y Nata, Gabriel Brooks, Cathy J Hatcher, John Burch, John Seidman, Christine E Seidman, Craig T Basson
Journal: Circulation (2008)

Mutations in TBX5 cause Holt-Oram syndrome (HOS) characterized by congenital heart malformation and upper limb deformity. Human TBX5 is expressed not only in a chamber specific myocardial distribution but also in coronary blood vessels. We have shown that mouse and chick Tbx5 are expressed in the proepicardial organ (PEO), a transitory structure from which epicardium and coronary vessels arise. We therefore investigated Tbx5 function during coronary vasculogenesis by manipulating Tbx5 gene dosage at critical points during chick and mouse cardioogenesis. Overexpression or inactivation of Tbx5 in chick PEO and chick epicardial cells leads to impaired migration and blocks incorporation of epicardial derived-cells (EPDCs) into coronary vessels. These data suggest Tbx5 acts during migration of PEO cells to the myocardium and migration of EPDCs into the subepicardium and myocardium. Epicardial restricted inactivation of Tbx5 using Wt1-cre and Tbx5 lox/lox mice reveals impaired migration (E10.5–11.5) of cytokeratin-positive PEO cells to the heart tube. However, at E14.5, mutant hearts display evidence of an epicardial layer suggesting delayed PE cell migration. However, unlike the flattened layer of epicardial cells in wildtype hearts, mutant hearts exhibit epicardial cells with irregular polygonal shapes and epicardial cyst-like structures lined by delaminated epicardium and filled with erythrocytes. At E17.5, we observe partial detachment of epicardium and nests of multiple contiguous subepicardial vessels without penetration into the myocardium. These observations suggest impaired migration of EPDCs into myocardium with consequent abnormally exuberant vasculogenesis restricted to the subepicardium. PECAM-1 expression analyses in E17.5 mutant embryos and neonatal mutant mice reveal marked reduction of myocardial coronary endothelial cells as well as defective coronary arteries and veins. These defects are associated with an upregulation of HIF1a in the myocardium, and, using an oxygen sensing dye, we observe relative tissue hypoxia in mutant myocardium. Our findings support a conserved requirement for Tbx5 in progenitor cell migration for the establishment of the coronary vasculature.
Brentuximab Vedotin in Combination with Bendamustine for Patients with Hodgkin Lymphoma who are Relapsed or Refractory after Frontline Therapy
Authors: Ann LaCasce, R. Gregory Bociek, Jeffrey Matous, Ahmed Sawas, Paolo Caimi, Stephen M. Ansell, Miguel Islas-Ohlmayer, Eric Cheung, Edward Agura, Caroline Behler, Howland Crosswell, Julie M. Vose, Neil Josephson, Ranjana Advani
Journal: Blood (2014)
Abstract 15315: Novel Drug Delivery Technology on Vascular Graft Implants Reduces Neointimal Hyperplasia in a Porcine Preclinical Model
Authors: Lisa K Jennings, Brian R Best, Timothy C Fabian
Journal: Circulation (2011)

Hundreds of implantable medical devices are made from the biologically inert material PTFE, and have been used in the medical industry since the 1950s. These devices may fail due to infection, infl...
Prefrontal Cortex 5-HT<sub>2</sub> Receptors in Depression: An [<sup>18</sup>F]Setoperone PET Imaging Study
Authors: Jeffrey H. Meyer, Shitij Kapur, Sylvain Houle, Jean DaSilva, Beata Owczarek, Gregory M. Brown, Alan A. Wilson, Sidney H. Kennedy
Journal: American Journal of Psychiatry (1999)

Widespread disturbances of serotonin (5-HT) are implicated in the pathophysiology of depression. Of 5-HT receptor abnormalities reported, the most replicated finding is increased 5-HT2 receptor binding in the postmortem prefrontal cortex of depressed suicide victims. The extent to which these findings exist in depressed persons without recent suicide attempts is uncertain. The objective of this study was to evaluate 5-HT2 receptors in depressed patients who were medication-free and who had not made recent suicide attempts.With the use of [18F]setoperone and positron emission tomography (PET), 5-HT2 receptor binding potential was assessed in 14 depressed and 19 healthy subjects. Exclusion criteria for depressed patients included use of antidepressant medication within the past 6 months, a history of suicide attempts within the past 5 years, other current axis I disorders including bipolar disorder, and the presence of psychotic symptoms. The 5-HT2 (setoperone) binding potential in the two groups of subjects was compared by analysis of covariance with age as the covariate.Age had a significant effect on 5-HT2 binding potential, but depression did not. The interaction of age and depression was not significant.The 5-HT2 binding potential is not increased in untreated depressed subjects who have not made recent suicide attempts. This negative finding does not rule out the possibility that there is a role for 5-HT2 receptors in treatment or that 5-HT2 receptors are increased in highly suicidal states.
Abstract 3134: Prognostic Implications of Contrast-Induced Nephropathy After Percutaneous Coronary Intervention in Patients With and Without Chronic Kidney Disease: Insights From CREDO-Kyoto Registry
Authors: Mitsuru Abe, Ryoji Taniguchi, Natsuhiko Ehara, Naritatsu Saito, Satoshi Shizuta, Yutaka Furukawa, Kazuaki Kataoka, Hisao Ogawa, Michio Kawasuji, Taku Hirai, Takeshi Morimoto, Toru Kita, Takeshi Kimura
Journal: Circulation (2008)

Background: Although contrast-induced nephropathy (CIN) is the third leading cause of hospital-acquired renal failure, long-term prognostic implication of CIN in patients with and without chronic k...
Abstract 15562: Left Ventricular Rest and Reserve Function is an Important Determinant of BNP Level in Patients with Surgically-Repaired Tetralogy of Fallot
Authors: Mitsuru Seki, Hirofumi Saiki, Satoshi Masutani, Hideaki Senzaki
Journal: Circulation (2011)

Background Right ventricular (RV) dysfunction caused by volume and/or pressure overload due to residual pulmonary lesion is an important prognostic factor in patients with surgically-repaired tetra...
Abstract 2573: Usefulness of 2D Speckle Tracking Echocardiography for Assessment of Tako-Tsubo Syndrome
Authors: Nicolas Mansencal, Rémy Pillière, Rami El Mahmoud, Jean-Christian Farcot, Thierry Joseph, Olivier Dubourg
Journal: Circulation (2007)

Background: The pathogenesis of Tako-Tsubo (TT) syndrome (stress-induced cardiomyopathy) is not yet understood. Velocity vector imaging (VVI) is a new echocardiographic technology that measures myocardial velocity and deformation using 2D speckle tracking. The aim of this study was to compare the pattern of VVI in pts with TT sy, coronary artery disease (CAD) and in healthy pts. Methods: We prospectively studied 36 consecutive pts divided in 3 groups: 12 pts with confirmed TT sy (group 1), 12 pts with CAD defined as a documented LAD occlusion (group 2) and 12 healthy pts (group 3) and all groups were age- and sex-matched. We systematically performed echocardiography in all pts, with the use of VVI technology, allowing to measure peak velocity (V), strain (S) and strain rate (SR) in basal, mid and apical septum and free wall (FW) in apical 4-chamber view. Results: Mean age was 76 ± 8 yo in each group (36 women). Mean values of V, S and SR in mid and apical septum and FW were significantly lower in TT sy (p&lt;0.04), as compared to group3, but not with group2. In group 1 as well as in control group, no significant differences for the values of V, S and SR were observed between basal septum and bas.FW, between mid septum and midFW and between apical septum and ap.FW (p=NS, Fig ), whereas in patients with CAD (group 2), basal septal V was significantly higher versus basal FW V (p=0.04) and apical septal V was significantly lower versus apical FW V (p=0.02). Conclusion: Our study suggests that VVI allows to distinguish patients with TT sy from those with CAD. In TT sy, left ventricular dysfunction is circular, whereas pts with LAD occlusion presented segmental wall motion abnormalities detected by VVI.
Focal Adhesion Kinase Inhibitors Reverse the Stromal Adhesion Phenotype of Ikaros-Mutant B-ALL, Induce Apopotosis, and Synergize with ABL1 Tyrosine Kinase Inhibitors: A New Paradigm for Pathogenesis and Therapy of High-Risk B-ALL
Authors: Ila Joshi, Nilamani Jena, Toshimi Yoshida, Leto Paraskevopoulou, Zhihong Zhang, Zhong-Ying Liu, Shane Korber, Daniela S. Krause, Irina M. Shapiro, David T. Weaver, Jonathan A. Pachter, Elisabeth M. Paietta, Richard A. Van Etten, Katia Georgopoulos
Journal: Blood (2014)
The Role Of tet2 DNA Methylcytosine Dioxygenase In Zebrafish Early Hematopoiesis
Authors: Huan-Chau Lin, Ken-Hong Lim, Yi-Hao Chiang, Wei-Ting Wang, Ching-Sung Lin, Yu-Cheng Chang, Ruey-Kuen Hsieh, Yuan-Yeh Kuo, Wen-Chien Chou
Journal: Blood (2013)
Authors' reply to Braillon and Bewley
Authors: M. Ussher, T. Coleman, R. West, P. Aveyard, S. Lewis
Journal: BMJ (2015)

We agree that in principle nicotine replacement therapy (NRT) should help pregnant smokers to stop smoking and NRT is licensed for use in pregnancy in the UK.1 2 However, randomised controlled trials have not shown NRT to be effective for smoking cessation in pregnancy.3 This may be because of inadequate nicotine dosing owing to faster nicotine metabolism during pregnancy. Besides the lack of evidence for NRT, data on its harms for the fetus are …
Relation of Streptococci to Influenza
Authors: Samuel S. Altshuler, Lucy Dell Henry
Journal: Annals of Internal Medicine (1929)

Article1 October 1929Relation of Streptococci to InfluenzaSAMUEL S. ALTSHULER, A.B., M.D., LUCY DELL HENRY, B.Sc.SAMUEL S. ALTSHULER, A.B., M.D.Search for more papers by this author, LUCY DELL HENRY, B.Sc.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-4-371 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMuch difference of opinion exists as to the causative organism or organisms of epidemic influenza. The general belief is that it is caused by the influenza bacillus, although many authorities are of the opinion that while this organism may be related to the infection, it is not the primary cause. With the development of our knowledge of the wide variety of clinical entities produced by the streptococci, different authorities have recently suggested that these organisms may be responsible for this disease. An opportunity was offered us during the recent influenza epidemic at Ann Arbor (Nov. 1928 to Feb. 1929), to...References1 ZINSSER H: Med. 1922, Vol. I, 215-216 (Translation). Google Scholar2 ZINSSER H: Med. 1922, Vol. I. Google Scholar3 DONALDSON R: Bacteriology of Influenza. Chap. VIII, p. 139. Crookshank's "Influenza" (Wm. Heinemann, London). Google Scholar4 HADLEY PJ: Infect. Diseases, 1927, Vol. 40, p. 1-312. CrossrefGoogle Scholar5 HADLEY PJ: Personal communication. Google Scholar6 OLITSKYGATES : Jour. Exper. Med., 1920 lxxiv, 1,497. Google Scholar7 OLITSKYGATES : Jour. Exper. Med., 1921 xxxiii, 361 and 373. CrossrefGoogle Scholar8 OLITSKYGATES : Jour. Exper. Med., 1922 xxxv, 553. CrossrefGoogle Scholar9 OLITSKYGATES : Jour. Exper. Med., 1921 xxxiii, 713. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*From the Department of Internal Medicine and the Bacteriological Laboratory, University Hospital, University of Michigan, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1929Volume 3, Issue 4Page: 371-377KeywordsBacillusHospital medicineResearch laboratories Issue Published: 1 October 1929 PDF downloadLoading ...
Two-year follow-up of inpatients with dissociative identity disorder
Authors: J W Ellason, C A Ross
Journal: American Journal of Psychiatry (1997)

A group of 135 inpatients with dissociative identity disorder was followed for 2 years to monitor treatment outcome.Fifty-four of the patients were located and reassessed after a 2-year period through the use of the same self-report measures and structured clinical interviews that had been initially administered.The patients showed marked improvement on Schneiderian first-rank symptoms, mood and anxiety disorders, dissociative symptoms, and somatization, with a significant decrease in the number of psychiatric medications prescribed. Patients who were treated to integration were significantly more improved than those who had not yet reached integration.These findings, although preliminary, provide empirical validation of previous clinical impressions that patients with dissociative identity disorder may respond well to treatment.