THE POVERTY OF THE IMMUNOLOGICAL MECHANISM IN PATIENTS WITH HODGKIN'S DISEASE
Authors: I N DUBIN
Journal: Annals of Internal Medicine (1947)

Article1 December 1947THE POVERTY OF THE IMMUNOLOGICAL MECHANISM IN PATIENTS WITH HODGKIN'S DISEASEI. N. DUBIN, M.D.I. N. DUBIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-6-898 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHodgkin's disease manifests itself as a proliferation of reticuloendothelial tissues, for which as yet no cause or causes have been established. Numerous kinds of bacteria have been found associated with this disease. Of these, many have in turn been proclaimed as the etiological agent only to be later unmasked as coincidental invaders. An interesting parallel to this fact is the increased susceptibility of these patients to intercurrent infections of various sorts; again here many different kinds of bacteria have been isolated. This greater susceptibility to infection seems paradoxical in the face of the massive proliferation of reticuloendothelial tissues, the cells...Bibliography1. SMITHDENISON WHGA: Blood testing and treatment program in Jefferson County, Alabama, Jr. Ven. Dis. Inform., 1946, xxvii, 94. Google Scholar2. VONDERLEHRUSILTON RALJ: Syphilis among men of draft age in the United States, Jr. Am. Med. Assoc., 1942, cxx, 1369. CrossrefGoogle Scholar3. MOSELEYCALLAWAYSHARPE VJLJS: A study of the incidence of syphilis in pregnant women and some results of therapy, Am. Jr. Obst. and Gynec., 1940, xxxix, 990. CrossrefGoogle Scholar4. MOSS ES: Written communication. Google Scholar5. ARONSON JD: Incidence of tuberculous infection in some communities of the South, Am. Jr. Hyg., 1931, xiv, 374. Google Scholar6. MICHELSON ID: A study of the relationship between calcified pulmonary nodules, the presence of living tubercle bacilli, and tuberculin sensitivity (in preparation). Google Scholar7. CANNON PR: Antibodies and protein-reserves, Jr. Immunol., 1942, xliv, 107. Google Scholar8. CANNONCHASEWISSLER PRWERW: Relationship of protein-reserves to antibody production; effects of low-protein diet and of plasmapheresis upon formation of agglutinins, Jr. Immunol., 1943, xlvii, 133. Google Scholar9. WISSLERWOOLRIDGESTEFFEE RWRLCH: Influence of aminoacid feeding upon antibody production in protein depleted rats, Proc. Soc. Exper. Biol. and Med., 1946, lxii, 199. CrossrefGoogle Scholar10. KREBS EG: Depression of gamma globulin in hypoproteinemia due to malnutrition, Jr. Lab. and Clin. Med., 1946, xxxi, 85. Google Scholar11. WISEPOSTON NBMA: Coexistence of brucella infection and Hodgkin's disease; clinical, bacteriologic and immunologic study, Jr. Am. Med. Assoc., 1940, cxv, 1976. CrossrefGoogle Scholar12. FORBUSGODDARDMARGOLISBROWNKERRY WDDWGIWGP: Studies on Hodgkin's disease and its relation to infection by Brucella, Am. Jr. Path., 1942, xviii, 745. Google Scholar13. WALLHAUSER A: Hodgkin's disease, Arch. Path., 1933, xvi, 522 and 672. Google Scholar14. PARKERJACKSONFITZHUGHSPIES FHGTD: Studies of diseases of lymphoid and myeloid tissues; skin reactions to human and avian tuberculin, Jr. Immunol., 1932, xxii, 277. Google Scholar15. STEINER PE: Skin reactions to avian and human tuberculinproteins in Hodgkin's disease, Arch. Int. Med., 1934, liv, 11. CrossrefGoogle Scholar16. MORQUIO L: Sobre dos casos de linfogranulomatosis maligna conpleuresias serofibrinosas, Arch. argent. de pediat., 1930, i, 573. Google Scholar17. BASTAI P: Ueber die klinische Bedeutung der Tuberkulinanergie bei malignem Lymphogranulom, Klin. Wchnschr., 1928, vii, 1606. CrossrefGoogle Scholar18. DE MARVAL L: Los pacientes afectados de linfogranulomatosis maligna son insensibles a dosis masivas de tuberculina bruta inyectada por via subcutanea, Prensa méd. argent., 1940, xxvii, 2310. Google Scholar19. MAINLAND D: The treatment of clinical and laboratory data, 1938, Oliver and Boyd, London. CrossrefGoogle Scholar20. KRUEGERMEYER FJOO: Lymphogranulomatosis (Hodgkin's disease): review of 60 cases, Jr. Lab. and Clin. Med., 1936, xxi, 682. Google Scholar21. SIMMONSBENET CCG: Hodgkin's disease; a report on the cases observed at the Collis P. Huntington Memorial Hospital from April, 1913 to July, 1916 with special reference to treatment with radium and the X-ray, Boston Med. and Surg. Jr., 1917, clxxvii, 819. CrossrefGoogle Scholar22. DAVIDSOHN I: Discussion of paper by Forbus and others,12 Am. Jr. Path., 1942, xviii, 745. Google Scholar23. STARLINGERWINANDS WE: Quoted by Wallhauser,13 Arch. Path., 1933, xvi, 522 and 672. Google Scholar24. BURNETT FM: The production of antibodies, 1941, MacMillan and Co., Ltd., Melbourne. Google Scholar25. MCJUNKIN FA: Supravital reaction to neutral red of the cells of lymph nodes of Hodgkin's disease, Arch. Path. and Lab. Med., 1926, ii, 815. Google Scholar26. MANKIN ZW: Experimentell-histologische Untersuchungen ueber normale und pathologisch veranderte Lymphknoten des Menschen, Beitr. z. path. Anat. u. z. allg. Path., 1936, xcvi, 248. Google Scholar27. LEWIS MR: The behavior of Dorothy Reed cells in tissue cultures, Am. Jr. Med. Sci., 1941, cci, 467. CrossrefGoogle Scholar28. LILLIE RD: Discussion of paper by Forbus and others,12 Am. Jr. Path., 1942, xviii, 745. Google Scholar29. BRANDT M: Beitrag zur pathologischen Anatomie der Lymphogranulomatose, Virchow's Arch. f. path. Anat., 1929, cclxxii, 400. CrossrefGoogle Scholar30. DESJARDINS AU: The etiology of lymphoblastoma, Jr. Am. Med. Assoc., 1934, ciii, 1033. CrossrefGoogle Scholar31. KRUMBHAAR EB: The present status of Hodgkin's disease, in: A symposium on the blood and blood-forming organs, 1939, The University of Wisconsin Press, Madison, pp. 148-166. Google Scholar32. STERNBERG C: Quoted by Wallhauser,13 Arch. Path., 1933, xvi, 522 and 672. Google Scholar33. FRAENKELMUCH EH: Bemerkungen zur Aetiologie der Hodgkinschen Krankheit und der Leukaemia lymphatica, München. med. Wchnschr., 1910, lvii, 685. Google Scholar34. L'ESPERANCE ES: Experimental inoculation of chickens with Hodgkin's nodes, Jr. Immunol., 1929, xvi, 37. Google Scholar35. L'ESPERANCE ES: Study of a case of Hodgkin's disease in a child, Jr. Immunol., 1930, xviii, 127. Google Scholar36. BUNTINGYATES CHJL: An etiologic study of Hodgkin's disease, Jr. Am. Med. Assoc., 1913, lxi, 1803. CrossrefGoogle Scholar37. BUNTINGYATES CHJL: An etiologic study of Hodgkin's disease, Jr. Am. Med. Assoc., 1914, lxii, 516. CrossrefGoogle Scholar38. BUNTING CH: Hodgkin's disease, Bull. Johns Hopkins Hosp., 1914, xxv, 177. Google Scholar39. PARSONSPOSTON PBMA: Pathology of human brucellosis; report of four cases with one autopsy, South. Med. Jr., 1939, xxxii, 7. CrossrefGoogle Scholar40. POSTONPARSONS MAPB: Isolation of Brucella from lymph nodes of patients with Hodgkin's disease, Jr. Infect. Dis., 1940, lxvi, 86. CrossrefGoogle Scholar41. STOERKZUCKER HCTF: Nutritional effects on the development and atrophy of the thymus, Proc. Soc. Exper. Biol. and Med., 1944, lvi, 151. CrossrefGoogle Scholar42. STOERKEISEN HCHN: Suppression of circulating antibodies in pyridoxin deficiency, Proc. Soc. Exper. Biol. and Med., 1946, lxii, 88. CrossrefGoogle Scholar43. STOERK HC: Effects of calcium deficiency and pyridoxin deficiency on thymic atrophy (accidental involution), Proc. Soc. Exper. Biol. and Med., 1946, lxii, 90. CrossrefGoogle Scholar44. OTT WH: Antipyridoxine activity of 2, 4-dimethyl-3 hydroxy-5-hydroxymethylpyridine in the chick, Proc. Soc. Exper. Biol. and Med., 1946, lxi, 125. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Memphis, Tennessee*Received for publication March 5, 1947.From the Division of Pathology and Bacteriology, University of Tennessee College of Medicine, Memphis. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byColliding Epidemics and the Rise of CryptococcosisSarcoidosis Following Chemotherapy for Hodgkin's DiseaseSuppressor Cells in Tumor-Host InteractionsHodgkin's disease: Unfolding concepts concerning its nature, management and prognosisImmune competence in a patient with Hodgkin's disease and relapsing toxoplasmosisThe immunoglobulins in Hodgkin's diseaseImmunological responsiveness against two primary antigens in untreated patients with Hodgkin's diseaseNonspecific Immune Responses in Hematosarcomas and Acute LeukemiasReconstitution of Cellular Immunity in Hodgkin's Disease with Transfer FactorStructure-Activity RelationshipsImmunpathologische Veränderungen bei der LymphogranulomatoseAnergy and tryptophan metabolism in Hodgkin's diseaseLong-term remission in hodgkin's disease after nitrogen mustard therapy.Report of a CaseHodgkin's disease: A follow-up study of patients surviving more than twenty years after the original diagnosisHuman Cancer ImmunologyClinical Management of Hodgkin's DiseaseTHE BLOOD SUPPLY OF THE EPIDERMIS TN THE RETICULOSESImmunpathologie bei der LymphogranulomatoseListeriosis complicating lymphomaHistological findings in human brucellosisBiological Factors Affecting the Prognosis and Treatment of CancerCryptococcus neoformans Pericarditis Associated with Hodgkin's DiseaseCHARLES P. DUVALL, M.D., PAUL P. CARBONE, M.D.Clinical features and diagnosis of Hodgkin's diseaseNormal immunologic reactivity in patients with the lymphoma mycosis fungoidesViral complement-fixing antibody in patients with Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma and chronic lymphatic leukemiaProduction of Antibodies against Viruses in Leukaemia and Related DiseasesHodgkin's Disease — Prognosis, Treatment and Etiologic and Immunologic ConsiderationsInfections, fever and host resistance in neoplastic diseasesAntibody Formation in Hodgkin's DiseasePatterns of Immunological Deficiency in Lymphomas and LeukemiasDANIEL G. MILLER, M.D.Antibodies to Blood Group A and B Substances in ReticulosesCIRCULATING ANTIBODIES IN RETICULOSESThe delayed skin test response in Hodgkin's disease and lymphosarcoma. Effect of disease activityChickenpox and leukemiaTISSUE REACTIONS TO ASPERGILLUS IN CASES OF HODGKIN'S DISEASE AND LEUKAEMIAHOST-PARASITE RELATIONSHIPS IN PATIENTS WITH DYSPROTEINEMIASAUTO-IMMUNITY IN MAN AND HOMOLOGOUS DISEASE IN MICE IN RELATION TO THE MALIGNANT LYMPHOMASTumours of the thyroid gland in relation to some general concepts of neoplasiaEVIDENCE FOR THE VIRUS ETIOLOGY OF HODGKIN'S DISEASECytomegalic inclusion disease in adultsInduction of Allergic Contact Dermatitis in Patients with the Lymphoma-Leukemia Complex**From the Department of Dermatology (Donald M. Pillsbury, M.D., Director), School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.Serum-properdin levels in patients with hodgkin's disease and carcinomaSarcoidosisTORULOSIS IN QUEENSLAND: REPORT OF FOURTEEN CASESDie TuberkulinempfindlichkeitMorbus BoeckDie Lymphogranulomatose des Mediastinums und der LungeDie TuberkulinempfindlichkeitDie Lymphogranulomatose des Mediastinums und der LungeMorbus BoeckHodgkin's disease and immunityAcute Disseminated Torulosis Associated with Hodgkin's DiseaseZur Ätiologie des Morbus BoeckA LIVER POISON WITH UNUSUAL PROPERTIESMEDIAN-NERVE PALSY FOLLOWING BEE-STINGSINFECTION WITH CRYPTOCOCCUS NEOFORMANSHodgkin's disease and allergySKIN SENSITIVITY IN SARCOIDOSISCutaneous Anergy and Hodgkin's DiseaseALTERED IMMUNOLOGIC REACTIONS IN SARCOIDOSIS*MAURICE SONES, M.D., F.A.C.P., HAROLD L. ISRAEL, M.D., F.A.C.P.Energy and Nitrogen Metabolism in CancerMycologyBCG VACCINATION AS A METHOD OF RESEARCHTHE STATUS OF THE SEARCH FOR A VIRUS IN HODGKIN'S DISEASEAlteration of Immunological Response in Malignancy: Decline of Proteus agglutininCryptococcosisAntibody Production in Pyridoxin-Deficient Rats 1 December 1947Volume 27, Issue 6Page: 898-913KeywordsBacteriaBacteriologyCellsGratitudeHodgkin lymphoma ePublished: 1 December 2008 Issue Published: 1 December 1947 PDF downloadLoading ...