AB1077 GLUCOCORTICOID TOXICITY INDEX IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: S. Dahmani, O. Sharapova, L. Gerasimova, T. Smirnova, N. Zhuravleva, S. Yastrebova, S. Kupriyanov
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> In patients with systemic lupus erythematosus, with prolonged use of glucocorticoids, irreversible damage to the internal organs, autoimmune organs, have a negative effect of cytostatics. The toxicity index of glucocorticoids can be used to evaluate negative manifestations in prolonged therapy of glucocorticoids for the purpose of timely correction of therapy. <h3>Objectives:</h3> To evaluate the adverse effect of prolonged use of glucocorticoids in patients with systemic lupus erythematosus using the glucocorticoid toxic index. <h3>Methods:</h3> The study included 35 patients with a diagnosis of system red lupus, established according to the classification criteria of SLICC 2012. All patients calculated the glucocorticoid toxicity index, the activity of the disease on the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI 2K and Indies) was evaluated SUS damage to Systemic Lupus International Collaboering Clinics (SLICC), a standard laboratory and immunological examination was carried out. <h3>Results:</h3> Patients included in the study were mainly female (94.3 %), with an average duration of the disease of 82 months. The activity of the SLEDAI 2K disease at the time of inclusion was an average of 7.9 points, the damage index on the SLICC scale is 1.2 points in 60% of patients, 40% of patients were detected by SLICC damage index. The average duration of glucocorticoid therapy for the period of the disease was 80 months. The maximum dose of glucocorticoids for the period of the disease is 90 mg, the total dose of glucocorticoids for the period of the disease is 28475 mg. We found the toxic effect of glucocorticoids in 72% of patients receiving therapy. The toxicity index of glucocorticoids was 17.8 points. The toxicity index of glucocorticoids correlated with the duration of the disease (r=0.321). In patients with an average duration of the disease for more than 5 years, the average value of the glucocorticoid toxicity index was significantly higher than in a group of patients with a duration of the disease 1–4 years (the criterion of Styudents P=0.024). <h3>Conclusion:</h3> In 72% of patients with a systemic lupusion, glucocorticoids have a toxic effect. The toxicity index of glucocorticoids increases significantly with a long course of the disease. The severity of the toxicity of glucocorticoids is influenced by the duration of the disease, the duration of glucocorticoid intake and the maximum dose of glucocorticoids for the period of the disease. The revealed reliable correlation of the toxicity index of glucocorticoids and the SLICC damage index allows it to be used as an additional component of the contribution of the contribution to the development of irreversible injuries of organs in patients with systemic lupus erythematosus. It is recommended to calculate the toxicity index of glucocorticoids in all patients with systemic lupus erythematosus. <h3>REFERENCES:</h3> <b>NIL.</b> <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>