INTRACUTANEOUS INOCULATION OF POLIOMYELITIS VIRUS IN MONKEYS AND ITS DETECTION IN THEIR STOOLS
Authors: James D. Trask, John R. Paul
Journal: Annals of Internal Medicine (1942)

Article1 December 1942INTRACUTANEOUS INOCULATION OF POLIOMYELITIS VIRUS IN MONKEYS AND ITS DETECTION IN THEIR STOOLSJAMES D. TRASK, M.D., JOHN R. PAUL, M.D.JAMES D. TRASK, M.D.Search for more papers by this author, JOHN R. PAUL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-6-975 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn order to learn if the virus of poliomyelitis can be detected in monkeys' stools after it has been inoculated intracutaneously the experiment presented in table 1 was performed. It may be described as follows:On April 2, 1941, stools were collected from 10 monkeys representing four (or five) different species and one chimpanzee. The animals were then inoculated intracutaneously with the SK strain of virus (generation XIV) from monkey No. 17-66, a green African monkey. Injections were made in 10 piqures in the left flank with 2 c.c. of a 10 per cent suspension of glycerolated cord. The inoculated...References1. TRASKPAUL JDJR: Experimental poliomyelitis in Cercopithecus aethiops sabaeus (the green African monkey) by oral and other routes, Jr. Exper. Med., 1941, lxxiii, 453-459. CrossrefGoogle Scholar2. ZUKERMANFULTON SJF: The nomenclature of primates commonly used in laboratory work, 1934, Tuttle, Morehouse & Taylor Company, New Haven. Google Scholar3. THOMSEN O: Experimentelle Untersuchungen über die Poliomyelitis, Zweite Mitteilung, Ztschr. f. Immunitätsforsch. u. exper. Therap., (Orig.) 1912, xiv, 198-217. Google Scholar4. BURNETJACKSONROBERTSON FMAVEG: The use of Macacus cynomolgus as an experimental animal, Australian Jr. Exper. Biol. and Med. Sci., 1939, xvii, 375-391. CrossrefGoogle Scholar5. LEVADITIKLINGLÉPINE CCP: Nouvelles recherches expérimentales sur la transmission de la poliomyélite par la voie digestive. Action du chlore sur le virus poliomyelitique, Bull. acad. méd., Paris, 1931, cv, 190-205. Google Scholar6. CLARKSCHINDLERROBERTS PFJDJ: Some properties of poliomyelitis virus, Jr. Bact., 1930, xx, 213-233. CrossrefGoogle Scholar7. CLARKROBERTSPRESTON PFDJWS: Passage of poliomyelitis virus through the intestinal tract, Jr. Prev. Med., 1932, vi, 47-58. Google Scholar8. FLEXNER S: Respiratory versus gastro-intestinal infection in poliomyelitis, Jr. Exper. Med., 1936, lxiii, 209-226. CrossrefGoogle Scholar9. HOWEBODIAN HAD: Poliomyelitis in the chimpanzee: a clinical-pathological study, Bull. Johns Hopkins Hosp., 1941, lxix, 149-181. Google Scholar10. SABINWARD ABR: Behavior of poliomyelitis virus in cynomolgus monkeys infected by the oral route, Jr. Bact., 1942, xliii, 86. Google Scholar11. KRAMERHOSKWITHGROSSMAN SDBLH: Detection of the virus of poliomyelitis in the nose and throat and gastrointestinal tract of human beings and monkeys, Jr. Exper. Med., 1939, lxix, 49-67. CrossrefGoogle Scholar12. SABINWARD ABR: Insects and epidemiology of poliomyelitis, Science, 1942, xcv, 300-301. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Haven, Connecticut*Presented at the St. Paul meeting of the American College of Physicians, April 22, 1942.From the Department of Pediatrics and the Section of Preventive Medicine of the Yale University School of Medicine.Aided by grants from the National Foundation for Infantile Paralysis, Inc.With the technical assistance of Mr. John T. Riordan.†Deceased. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe cutter incidentVirus ResearchExperimental infections with enterovirusesAllgemeine Pathogenese der Viruskrankheiten des ZentralnervensystemsPoliomyelitis-Forschungen in USA. 1942?1946 1 December 1942Volume 17, Issue 6Page: 975-978KeywordsInoculationPediatricsPoliomyelitisPreventive medicine ePublished: 1 December 2008 Issue Published: 1 December 1942 PDF downloadLoading ...