tbuckley/cabot-search huggingface dataset:
A Woman Attempting to Discontinue Hormone TherapyA Woman Attempting to Discontinue Hormone Therapy
Authors: Michael Kleerekoper
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5926: Cardiac Electrical Resynchronization Therapy Combining HIS Bundle and Left Ventricular Pacing is Effective in the Treatment of Severe Heart Failure
Authors: Stanley Tung, Kesava Rajagopalan, Andy Ignaszewski, Jonathan Affolter
Journal: Circulation (2008)

Introduction: It is known that Cardiac Resynchronization Therapy (CRT) combining right ventricular (RV) apex pacing and left ventricular pacing (LVP) is ineffective in up to 35% of heart failure (HF) patients. Our hypothesis is that RV apical pacing bypasses the rapidly conducting right bundle and may further impede ventricular activation with LBBB hence a more physiological CRT is via HIS Bundle pacing (HBP) and LVP. We report of our early experience with Cardiac Electrical Resynchronization Therapy (CERT) incorporating HBP with LVP in patients with severe HF. Methods: Patients indicated for CRT were approached for CERT. In addition to an atrial and LV lead, patients also received a HBP lead. An active fixation lead (SelectSecure/Site® Medtronic) was used directly for HIS Bundle mapping and pacing. HBP implant thresholds, procedure and fluoroscopy times, pre and post implant QRS, PR interval, and NYHA class were collected. Student t -test was used for analysis. Results: 15 patients (13 male, mean age 70yrs) referred for CRT underwent successful CERT with mean follow up of 3.5±4.3 months. The mean implant HBP threshold, procedure and fluoroscopy time were 1.6V/0.6ms, 150min, and 26min respectively. All patients had QRS shortening with a mean of 64±21ms (pre CERT 182ms, post CERT 118ms, p&lt;0.0001, figure ) and mean PR shortening of 81±101ms (pre CERT 254ms, post CERT 173ms, p&lt;0.05). 13 patients had improvement of at least one NYHA class. Conclusions: HBP with LVP is effective in achieving electrical resynchronization, and has resulted in early improvement of HF symptoms. Evidence of reverse remodeling is pending. CERT needs to be further validated before considering for wide adoption.
Abstract 303: Arteriogenesis Requires Leukocytic Co-Signaling of TLR2 and TLR4
Authors: Imo Hoefer, Arjan Schoneveld, Sebastian Grundmann, Karlijn van Keulen, Pieter Bot, Leo Timmers, Gerard Pasterkamp, Dominique de Kleijn
Journal: Circulation (2007)

Background: Collateral artery growth (arteriogenesis) is promoted by the accumulation of leukocytes in the perivascular tissue. Ligand binding to Toll-Like Receptors (TLR), a family of 13 receptors which forms an important part of the innate immune system, leads to activation of inflammatory cells such as leukocytes. We therefore hypothesized that TLRs, in particular TLR expression on leukocytes, plays a prominent role in adaptive arteriogenesis. Methods : Localization of TLR expression in growing collateral arteries was assessed by immunohistochemistry. The role of TLR signaling during arteriogenesis was assessed in TLR2−/− mice on a C57BL/6J background, TLR4−/− mice on a BALB/c background and their respective controls after femoral artery occlusion. Furthermore, 6 weeks old mice underwent lethal irradiation and subsequent bone marrow (bm) transplantation before undergoing femoral artery occlusion 6 weeks later. Wild-type mice (WT) received either WT bm or TLR −/− bm, whereas TLR −/− mice received WT bm. On day 7, microsphere perfusion measurements were performed to assess collateral function. Results : Immunohistochemistry revealed that TLRs are mainly expressed by infiltrating leukocytes during arteriogenesis. In TLR2 and TLR4 deficient mice, collateral perfusion was significantly reduced compared to controls (perfusion occluded vs. unoccluded hind limb: TLR 2 −/−: 37.7 ± 1.8 %; C57BL6J: 54.9 ± 6.0%; TLR 4−/−: 15.8 ± 5.1%; Balb-C: 25.1± 5.1 %; p&lt;0.01) After transplantation of WT bm into WT mice, collateral function was decreased to a minor, non significant degree compared to WT mice (C57BL/6J into C57BL/6J: 49.7 ± 2.6%; BALB/c bm into BALB/c: 23.1 ± 1.0%. After transplantation of TLR −/− bm into WT mice, arteriogenesis was significantly reduced (TLR2 −/− bm into C57BL/6J: 38.2 ± 3.5%; TLR4 −/− bm into BALB/c: 16.7 ± 1.5%), whereas WT bm transplantation into TLR −/− mice normalized the arteriogenic response (C57BL/6J bm into TLR2 −/−: 46.5 ± 5.5%; BALB/C bm into TLR4 −/−: 22.6 ± 3.3%). Conclusion : Arteriogenesis is impaired under conditions of TLR2 or TLR4 deficiency. Among the many different cell types that are able to express Toll-Like receptors, TLR signaling of circulating leukocytes seems to be of major importance for adaptive arteriogenesis.
LEAD IN THE ENVIRONMENT: PRELIMINARY COMMUNICATION AREAS
Authors: H A Waldron, Tkrr Shanmukha
Journal: Journal of the Royal Society of Medicine (1979)

Reference is made to the concern felt about the increase in airborne lead concentration in some areas due to the use of lead in petrol. A description is given of blood lead level surveys made in birmingham, of which the results are tabulated. The survey covered adults, school children, and pre-school children. A comparison is made of the group results. The exposure in particular of young children in the city centre to high airborne lead levels is considered, and further studies may clarify any possible high blood lead content resulting from deficiency of calcium in some children's diet. It is considered that the presence of some toxic material is not necessarily hazardous or requiring action. This paper was read to the section of occupational medicine on 18 January 1979. (TRRL)
Initial imaging findings using [<sup>18</sup>f]GE-148 ([<sup>18</sup>F]FACBC) PET/CT in subjects with primary prostate cancer.
Authors: S. Johansson, J. Sorensen, M. A. Lax, R. Owenius
Journal: Journal of Clinical Oncology (2010)

e15138 Background: Existing imaging techniques have limitations for the detection and staging of prostate cancer. 1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid ([18F]GE-148), also known as [18F]FACBC, is a synthetic L-leucine analogue-based PET imaging agent, being developed by GE Healthcare. Its uptake is likely mediated by the L large-neutral amino acid transport system. [18F]GE-148 has potential clinical utility for optimised staging of disease and choice of therapy. Methods: Six patients with primary prostate cancer underwent up to 120 min dynamic PET/CT imaging after injection of 408-431 MBq [18F]GE-148. Summed data over 1 to 15 min p.i. were assessed visually and quantitatively. Standardized Uptake Values (SUVs) for malignant and normal prostate tissue were correlated with standard-of-care imaging and biopsy results. Results: Uptake of [18F]GE-148 into tumour tissue was rapid with slow washout over the first 30 min, allowing for effective visualisation of malignant prostate lesions in all 6 subjects. Multiple tumour foci were observed in 3 subjects, lymphatic involvement in 1 subject, and vesicular involvement in 5 subjects, corresponding to MRI findings. Preliminary data indicate a possible correlation between SUV and increasing Gleason score. Conclusions: [18F]GE-148 is an effective agent for delineating primary prostate tumours, lymph node metastases, and vesicle involvement. Such diagnostic information may have potential clinical utility for staging of primary tumours, monitoring of early recurrence, radiotherapy planning, and monitoring early response to treatment. Subsequent trials are planned to further examine the clinical role of [18F]GE-148, with the expectation of commercialization. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration GE HealthCare GE HealthCare GE HealthCare
Abstract 1092: Dalcetrapib Binds to and Changes the Conformation of CETP in a Unique Manner (Differing to That Observed With Torcetrapib)
Authors: Cyrille Maugeais, Christine Magg, Gregor Dernick, Hugues Matile, Elisabeth von der Mark, Philippe Pflieger, Walter Huber, Ralf Thoma, Makoto Kakutani, Hiroshi Okamoto, Eric J Niesor
Journal: Circulation (2009)
Parasitology for Medical Students.
Authors: Alex. Mills Kennedy
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 379: Enhancement of TRPC6-mediated Ca <sup>2+</sup> Entry in Pulmonary Artery Smooth Muscle Cells of Idiopathic Pulmonary Arterial Hypertension Patients
Authors: Ying Yu, Olga Safrina, Oleksandr Platoshyn, Michael D Cahalan, Lewis J Rubin, Jason X Yuan
Journal: Circulation (2007)

Background &amp; Hypothesis: Excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) and sustained pulmonary vasoconstriction are thought to play critical roles in the development of idiopathic pulmonary arterial hypertension (IPAH). Recently, we demonstrated that upregulation of the canonical transient receptor potential 6 (TRPC6) channel contributes to excessive proliferation of PASMCs isolated from IPAH patients. This study aimed at characterizing whether up-regulated TRPC6 expression affects resting cytosolic [Ca 2+ ] ([Ca 2+ ] cyt ) level and Ca 2+ entry in PASMCs of IPAH patients. Methods &amp; Results: [Ca 2+ ] cyt was measured by fluorescence ratio video imaging with the Ca 2+ indicator fura-2. 1-Oleoyl-2-acetyl-sn-glycerol (OAG), a cell-permeable diacylglycerol analog that activates TRPC6 channels, was used to stimulate channel activities in the presence of extracellular Ca 2+ . The resting [Ca 2+ ] cyt andOAG-mediated increase in [Ca 2+ ]cyt were significantly higher in PASMCs from IPAH patients compared to PASMCs isolated from secondary pulmonary artery hypertension and normotensive patients. In PASMCs from IPAH patients, inhibition of TRPC6 expression by adenovirus-mediated siRNA specifically targeted the human TRPC6 gene led to an approximately 90% reduction of TRPC6 mRNA and protein levels and significantly attenuated OAG-mediated increase in [Ca 2+ ] cyt . Treatment of the IPAH-PASMCs with siRNA also decreased the resting [Ca 2+ ] cyt and significantly inhibited cell proliferation in comparison to cells treated with scrambled control siRNA. Furthermore, exogenous overexpression of human TRPC6 increased the resting [Ca 2+ ] cyt and enhanced OAG-mediated Ca 2+ entry in normal PASMCs. C onclusions: These results suggest that upregulation of TRPC6 channels in PASMC from IPAH patients serves as an important pathway for agonist-mediated Ca 2+ entry, mitogen-mediated PASMC proliferation and, ultimately, pulmonary vascular remodeling. Targeting TRPC6 expression and function in PASMCs would help develop novel therapeutic approaches for IPAH patients.
Outcomes of allogeneic stem cell transplantation in hepatosplenic T-cell lymphoma
Authors: A Rashidi, A F Cashen
Journal: Blood Cancer Journal (2015)

Hepatosplenic T-cell lymphoma (HSTCL) is a rare but aggressive type of non-Hodgkin lymphoma that primarily involves the sinusoids of the liver, red pulp of the spleen and the sinuses of the bone marrow.The specific rearrangement of the expressed T-cell receptor chain genes (TCR-αβ vs γδ) determines the subtype of the disease (HSαβTCL vs HSγδTCL).HSαβTCL is the rarer subtype with fewer than 30 cases reported in the literature. 1 HSγδTCL is classically described in patients with inflammatory bowel disease treated with azathioprine, those on chronic immunosuppression following solid organ transplantation, 2,3 and patients treated with TNF-α inhibitors. 4 On the other hand, most reported cases of HSαβTCL do not seem to have an underlying immune-related condition. 1Hepatosplenomegaly, cytopenias and stage IVB diseases are typical.Common cytogenetic abnormalities include isochromosome 7q and trisomy 8, and neoplastic T cells are usually CD4 -CD8 -. 5 HSTCL has a tendency to affect younger individuals with a median age of 20-30 years.Whereas males are significantly more commonly affected with the γδ subtype (male:female (M:F) ratio of 10:1), 3 the αβ subtype has a slight female preponderance (F:M ratio of 1.5:1). 1 Without allogeneic stem cell transplantation (allo-SCT), HSTCL is an almost invariably fatal disease characterized by chemorefractoriness, unremitting Figure 1.Outcomes following allo-SCT in patients with hepatosplenic T-cell lymphoma.Cumulative incidence of relapse, cumulative incidence of non-relapse mortality, RFS and OS are shown in panels a, b, c and d, respectively.
STIMULATION OF MYOBLAST PROLIFERATION BY BASIC FIBROBLAST GROWTH-FACTOR AND PLATELET-DERIVED GROWTH FACTOR-BB MAY BE MEDIATED BY THE EARLY GROWTH-RESPONSE GENE-1 (EGR-1)
Authors: A Maass, C Grohe, B Wollnik, C Kubisch, S Oberdorf, H Vetter, L Neyses
Journal: Circulation (1993)
Fast Green- and Light Green-Induced Tumors: Induction, Morphology, and Effect on Host
Authors: M. L. Hesselbach, R. W. O'Gara
Journal: JNCI Journal of the National Cancer Institute (1960)

Journal Article Fast Green- and Light Green-Induced Tumors: Induction, Morphology, and Effect on Host Get access M. L. Hesselbach, M. L. Hesselbach Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases,5 and Laboratory of Pathology, National Cancer Institute,5Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar R. W. O'Gara R. W. O'Gara Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases,5 and Laboratory of Pathology, National Cancer Institute,5Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 24, Issue 4, April 1960, Pages 769–793, https://doi.org/10.1093/jnci/24.4.769 Published: 01 April 1960 Article history Received: 01 June 1959 Revision received: 19 October 1959 Published: 01 April 1960
Elevation of plasma RANTES levels and prognosis in patients treated with gefitinib
Authors: K. Yamaguchi, S. Kanazawa, M. Muramatsu, Y. Kinoshita, S. Nomura
Journal: Journal of Clinical Oncology (2005)

3215 Background: Recently we reported that plasma levels of thromboxane B2, soluble P-selectin were increased in patients received gefitinib. We think that gefitinib may induce platelet activation by activation. It was reported that activated platelet released RANTES. The aim of this study was to identify differences in plasma levels of RANTES between clinical cases. Then we measured plasma concentrations of RANTES in patients received gefitinib. Methods: Patients with a diagnosis of NSCLC were entered into this study. Blood samples were withdrawn from the patients with NSCLC before, one week later and two weeks later of administration of gefitinib. RANTES were measured with a monoclonal antibody-based enzyme-linked immuno solvent assay kit. A total of 16 patients were entered into the study. The characteristics of the study group were: age: 42–82 years (median: 62 years); gender: male vs. female = 9 vs. 7; PS: 0–1 vs. 2–4 = 13 vs. 3; tumor histology: adenocarcinoma vs. squamous cell carcinoma = 12 vs. 4. Eight patients were responders and the other 8 patients were non-responders. Results: The plasma concentration of RANTES had significantly increased after receiving of gefitinib (before vs. one week vs. two weeks = 42.3+/-16.9 vs. 50.8+/-23.6 (p<0.05) vs. 52.4+/-20.8 (p<0.05) n=16). In responders the plasma concentration of RANTES tended to increase after receiving of gefitinib (before vs. one week vs. two weeks = 38.5+/-13.3 vs. 44.3+/-12.6 vs. 52.2+/-23.8 (p<0.05) n=8), but in non-responders, there was no statistically significance. ΔRANTES increased after receiving of gefitinib in responders (one week, two weeks = 119.8%+/-25.7, 136.1%+/-42.2 (p<0.05) n=8), but no statistical significance in non-responders (one week, two weeks = 126.6+/-43.6, 122.2+/-42.4 n=8). Conclusions: We thought that lymphocyte infiltration was induced by medication of gefitinib. We think that gefitinib may induce the secretion of RANTES directly or indirectly, therefore, gefitinib may have an effect of change active lymphocyte response (ALR) negative tumor to ALR positive tumor. We concluded that one of anticancer mechanisms of gefitinib was inducing RANTES, and if the base line levels were lower, more elevation of plasma RANTES was favorable outcome. No significant financial relationships to disclose.
Cutaneous Investigation in Health and Disease: Noninvasive Methods and Instrumentation
Authors: Jean-Luc Leveque
Journal: Annals of Internal Medicine (1989)

The first in a new series on clinical dermatology that will have a broad focus and cover basic science as well as clinical issues. This volume comprises 16 chapters addressing various aspects of new (exquisitely accurate) methods of measurement and their interpretation. Annotation copyright Book New
Abstract 11676: Atheroprotective Communication Between Endothelial Cells and Smooth Muscle Cells via KLF2-Dependent Enrichment of miRNAs in Microvesicles
Authors: Eduard Hergenreider, Reinier A Boon, Susanne Heydt, Karine Treguer, Thomas Bottger, Anton J Horrevoets, Andreas M Zeiher, Thomas Braun, Carmen Urbich, Stefanie Dimmeler
Journal: Circulation (2011)

The transcription factor Kruppel-like factor 2 (KLF2) was identified as critical mediator of the effects of atheroprotective flow on endothelial cells (ECs). Since miRNAs were shown to play key ro...
Getting research findings into practice: Implementing research findings in developing countries
Authors: P. Garner, R. Kale, R. Dickson, T. Dans, R. Salinas
Journal: BMJ (1998)

This is the last in a series of eight articles analysing the gap between research and practice

Series editors: Andrew Haines and Anna Donald

Developing countries have limited resources, so it is particularly important to invest in health care that works. The growing number of relevant systematic reviews can assist policymakers, clinicians, and consumers in making informed decisions. Developing countries have led the way in generating approaches to ensure professional standards of behaviour through interventions such as producing guidelines and introducing essential drug programmes, and by producing reliable research summaries to help ensure that policies are based on good evidence.

### Summary points

Yakamul, an illiterate villager in Papua New Guinea, was sitting by a fire listening to a health professional from the West tell her to take chloroquine throughout her pregnancy. She responded: “I ting merisin bilong ol wait man bai bagarapim mi [I think this Western medicine could harm me].” She had never attended a workshop in critical appraisal butshe realised that medicine could do her more harm than good. Her response reminds health professionals to ask fundamental questions about the care we provide and of our responsibility …
Ultrasound Imaging. Liver, Spleen, Pancreas.
Authors: David O. Cosgrove, V. R. McCready
Journal: Annals of Internal Medicine (1983)

This major work is an outstanding collection of state of the art ultrasound images accompanied by explicit explanatory diagrams and notes. Offering a comprehensive appraisal of ultrasound imaging of the upper abdomen, the book covers the anatomy of the upper abdomen as well as the normal and abnormal appearance of each organ.
Studies in Asphyxia:
Authors: W. P. Yant
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal