CLINICAL STUDIES WITH THE AID OF RADIO-PHOSPHORUS. III. THE ABSORPTION AND DISTRIBUTION OF RADIO-PHOSPHORUS IN THE BLOOD OF, ITS EXCRETION BY, AND ITS THERAPEUTIC EFFECT ON, PATIENTS WITH POLYCYTHEMIA
Authors: L. A. Erf, J. H. Lawrence
Journal: Annals of Internal Medicine (1941)

Article1 August 1941CLINICAL STUDIES WITH THE AID OF RADIO-PHOSPHORUS. III. THE ABSORPTION AND DISTRIBUTION OF RADIO-PHOSPHORUS IN THE BLOOD OF, ITS EXCRETION BY, AND ITS THERAPEUTIC EFFECT ON, PATIENTS WITH POLYCYTHEMIAL. A. ERF, M.D., J. H. LAWRENCE, M.D.L. A. ERF, M.D.Search for more papers by this author, J. H. LAWRENCE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-2-276 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this paper is (a) to indicate the amount of radio-phosphorus (P32) retained by various fractions of blood of four normal individuals and six patients with polycythemia; (b) to indicate the amount of P32 excreted in the urine and feces of the normal individuals and some of the patients; and (c) to present the hematological and clinical findings of the patients before and after the administration of P32.1MATERIALS AND METHODSThe radioactive phosphorus was produced by the Berkeley Cyclotron.2The four normal individuals were robust, ambulatory workmen with recently healed fractures, all of whom had received the...References1. LAWRENCE JH: Nuclear physics and therapy: preliminary report on a new method for treatment of leukemia and polycythemia, Radiology, 1940, xxxv, 51. CrossrefGoogle Scholar2. LAWRENCECOOKSEY EOD: On the apparatus for the multiple acceleration of light ions to high speeds, Phys. Rev., 1936, l, 1131. CrossrefGoogle Scholar3. BERNSTEINJONESERICKSONWILLIAMAVRINMACY SSRLBUHHIGI: A method for the preparation of post-hemolytic residue or stroma of erythrocytes, Jr. Biol. Chem., 1937-38, cxxii, 507. Google Scholar4. TUTTLESCOTTLAWRENCE LWKGJH: Phosphorus metabolism in leukemic blood, Proc. Soc. Exper. Biol. and Med., 1939, xli, 20. CrossrefGoogle Scholar5. EISENMANOTTSMITHWINKLER AJLPA: A study of the permeability of human erythrocytes to potassium, sodium and inorganic phosphate by use of radioactive isotopes, Jr. Biol. Chem., 1940, cxxxv, 165. CrossrefGoogle Scholar6. TUTTLESCOTTLAWRENCE LWKGJH: Studies on neoplasms with the aid of radioactive phosphorus. II. The phosphorus metabolism of the nucleoprotein, phospholipid and acid soluble fractions of normal and leukemic mice, Jr. Clin. Invest., 1941, xx, 57. CrossrefGoogle Scholar7. LAWRENCESCOTTTUTTLE JHKGLW: Studies on leukemia with the aid of radioactive phosphorus, New Internat. Clin., 1939, iii, 33. Google Scholar8. ERF LA: Clinical studies with the aid of radioactive phosphorus. II. Assay of radioactivity of tissues of patients dead of leukemia, Jr. Clin. Invest. (In press.) Google Scholar9. TUTTLEERFLAWRENCE LWLAJH: To be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: California*Received for publication April 15, 1941.From the Radiation Laboratory and the Department of Medicine, University of California.This work was aided by the John and Mary R. Markle Foundation.†Wm. R. Kenan, Jr., Fellow. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLeukemia in Polycythemia Vera Relationship to Splenic Myeloid Metaplasia and Therapeutic Radiation DoseJOHN H. LAWRENCE, M.D., D.SC., F.A.C.P., H. S. WINCHELL, M.D., PH.D., F.A.C.P., W. G. DONALD, M.D., F.A.C.P.Historische Übersicht der Anwendung von IsotopindicatorenBlutkrankheitenPOLYCYTHÆMIA VERAMetabolism of Folic Acid and Citrovorum Factor in Leukemic CellsLactic Acid Production by Polymorphonuclear LeukocytesBlutkrankheitenThe biological half-life of radioactive phosphorus in the blood of patients with leukemia.III. Erythrocytes—with deviations of observations from predicted valuesThe biological half-life of radioactive phosphorus in the blood of patients with leukemia.IV. Leukocytes—radioactive phosphorus content and the relation to plasma-P32 levelsRadiophosphorus in the Treatment of Blood DyscrasiasRadiophosphorus as the treatment of choice in primary polycythemia 1 August 1941Volume 15, Issue 2Page: 276-290KeywordsAIDSBloodExcretionHematology and oncologyPhosphorusPolycythemiaResearch laboratoriesUrine ePublished: 1 December 2008 Issue Published: 1 August 1941 PDF downloadLoading ...