tbuckley/cabot-search huggingface dataset:
Final results and pharmacoeconomic analysis of a trial comparing two neoadjuvant chemotherapy (CT) regimens followed by surgery in patients with resectable non small cell lung cancer (NSCLC): a phase II randomised study by the European Lung Cancer Working Party
Authors: Thierry Berghmans, Jean-Jacques Lafitte, Vicente Giner, M.C. Berchier, Arnaud Scherpereel, David Lewin, Marianne Paesmans, Anne-Pascale Meert, Thierry Bosschaerts, Nathalie Leclercq, Jean-Paul Sculier
Journal: Journal of Thoracic Oncology (2011)
Abstract 322: Role of T-Type Calcium Current in Cardiac Remodeling Probed with Genetically Engineered Knockout Mice
Authors: Khai Le Quang, F Poulin, Marc-Antoine Gillis, Philippe Comtois, Pierre Coutu, Jean-Claude Tardif, Danshi Li, Paul Levesque, F. Charpentier, Stanley Nattel
Journal: Circulation (2007)

Background: Previous studies suggested that T-type Ca 2+ -current (I CaT ) blockers suppress disease-related cardiac remodeling, but all available I CaT -blockers have non-specific actions on other currents and/or functions. To obtain a clearer sense of the role of I CaT in cardiac remodeling, we studied mice with the principal cardiac I CaT subunit (Cav3.1) knocked out. Methods: Adult male Cav3.1 knockout mice (KO) were compared with wild type (WT). LAD-ligation was performed to create anterior-wall myocardial infarction (MI). Echocardiography was used to evaluate cardiac performance at baseline, 2-w and 4-w post-MI. Intracardiac programmed stimulation was performed 4-w post-MI. Standard pacing protocols were used to determine atrial and ventricular electrophysiological properties and to induce arrhythmias. Results: Surface ECG parameters were examined in 10 KO and 10 WT mice prior to LAD ligation. At baseline, PQ interval was significantly longer in KO mice than in WT animals (44 ± 1 ms vs 40 ± 1 ms, respectively; p &lt; 0.05); no significant differences were observed in RR, QRS or QTc intervals. At 10 minutes post-MI, WT (but not KO) mice showed increased heart rate (p = 0.002). Baseline echocardiography showed smaller LV fractional shortening (FS) and ejection fraction (EF) in KO mice compared with WT (34 ± 1% KO vs 42 ± 3% WT; 69 ± 2% KO vs 77 ± 3% WT; respectively, p &lt; 0.05). At 4-w post-MI, FS and EF of KO mice were still smaller than WT mice (15.5 ± 1.6% vs 21.0 ± 1.5%; 37.4 ± 3.2% vs 48.1 ± 2.8%, respectively; p &lt; 0.05). At baseline and 4-w post-MI, the contractility index (pressure-volume curves) was decreased in KO mice (p &lt; 0.05). Intracardiac electrophysiological recordings revealed no differences in atrial and ventricular ERP or sinus node recovery time for WT vs KO. At 4-w post-MI, extrastimuli induced sustained atrial fibrillation (&gt; 2 s) in 60% (6/10) KO mice, versus 17% (1/6) in WT (p = 0.05) and ventricular tachyarrhythmias in 82% (9/11) of KO mice versus 17% (1/6) of WT (p &lt; 0.01). Conclusion: Contrary to previous studies with (imperfectly selective) pharmacological agents having T-type Ca 2+ channel blocking actions, our findings suggests that reductions in I CaT do not favorably alter post-MI remodeling and may negatively affect cardiac function and arrhythmias.
The expression of Ki-67, a marker of proliferative activity, in resected non-small cell lung cancer.
Authors: Benoît Martin, Céline Mascaux, Jean-Marc Verdebout, Marianne Paesmans, Ghizlane Rouas, Alain Verhest, Thierry Bosschaerts, Vincent Ninane, Jean-Paul Sculier
Journal: European Respiratory Journal (2001)
Abstract 21194: TRIM63, Encoding MuRF1, is a Novel Gene for Human Hypertrophic Cardiomyopathy
Authors: Suet Nee Chen, Gabriela Rodriguez, Grazyna Czernuszewicz, Un-Ho Jin, Jianping Jin, Ali J Marian
Journal: Circulation (2010)

TRIM63 encodes Muscle Ring Finger 1 (MuRF1) protein, which is a sarcomere M line with E3 ubiquitin (Ub) ligase function. MuRF1 regulates muscle trophic homeostasis and is considered a muscle atroph...
Transdermal delivery of fluorescein isothiocyanate-dextrans using the combination of microneedles and low-frequency sonophoresis
Authors: Boonnada Pamornpathomkul, Sureewan Duangjit, Suvida Laohapatarapant, Theerasak Rojanarata, Praneet Opanasopit, Tanasait Ngawhirunpat
Journal: Asian Journal of Pharmaceutical Sciences (2015)

This study aimed to evaluate the patient-friendly methods that are used in the delivery of hydrophilic macromolecules into deep skin layers, in particular, the combination of microneedles patch (MNs patch) and low-frequency sonophoresis (SN). The hydrophilic macromolecule drug fluorescein isothiocyanate (FITC)-dextrans (FD-4: MW 4.4 kDa) was used as the model drug in our experimental design. In this study, excised porcine skin was used to investigate and optimize the key parameters that determine effective MNs- and SN-facilitated FD-4 delivery. In vitro skin permeation experiments revealed that the combination of MNs patch with SN had a superior enhancing effect of skin permeation for FD-4 compared to MNs alone, SN alone or untreated skin, respectively. The optimal parameters for the combination of MNs and SN included the following: 10 N insertion force of MNs, 4 W/cm2 SN intensity, 6 mm radiation diameter of the SN probe, 2 min application time, and the continuous mode duty cycle of SN. In addition, vertical sections of skin, clearly observed under a confocal microscope, confirmed that the combination of MNs and SN enhanced permeation of FD-4 into the deep skin layers. These studies suggest that the combination of MNs and SN techniques could have great potential in the delivery of hydrophilic macromolecules into deep skin.
Abstract 16531: Absence of Remodeling Benefit of Lv-crt Over Bv-crt in Patients With Heart Failure and Wide Qrs: Insight From the Evaluation of Resynchronization Therapy for Heart Failure (EARTH) Trial
Authors: Anique Ducharme, Halyna Prylutska, Francois Harel, Eileen O'Meara, Joel Lavoie, Nancy Frasure-Smith, Asmaa Mansour, Michel White, Bernard Thibault
Journal: Circulation (2011)

Purpose: Cardiac Resynchronization Therapy (CRT) is recommended for patients with advanced heart failure (HF) and wide QRS, but 30% of these patients fail to respond to CRT. The EARTH trial showed ...
Inhaler proficiency following the introduction of a new inhaler management policy for hospitalised patients
Authors: Deirdre Long, Anne Marie Lyons, Tara Byrne, Imran Sulaiman, Richard Costello
Journal: European Respiratory Journal (2014)

Inhaled medications are crucial treatments in many respiratory conditions. However inhaler adherence is poorly studied, particularly in the hospitalised patient. Historically inhalers are left with inpatients and charted in the Drug Kardex to be administered as prescribed. This audit follows the implementation of a new Inhaler Management Policy for hospitalised patients. It was hypothesized that following the implementation of the policy poor inhaler technique would be identified and corrected prior to discharge

All patients on inhalers admitted from the Emergency Department were included in the audit over a four month period. Verbal consent was obtained. 126 patients were observed, 100(n=100) female=58 and male=42 completed, 26 uncompleted=discharge early or infection control. Mean age=68(-49/+19). Diagnosis COPD (55%), asthma(24%) and other(21%). A ten point Inhaler Proficiency Score (IPS) was used to assess inhaler technique.

On admission, 54 patients had good inhaler technique, IPS ≥9; 19 were too ill to be assessed properly. At discharge, 21% of the patients with a low initial IPS improved to≥9 while 25% had no improvement (all these patients had an initial IPS <5 at admission). Overall, 20% required intervention, 16 had further inhaler education and 4 were deemed not suited for inhalers.

Poor inhaler technique on admission improved with appropriate intervention as part of the new Inhaler Management Policy. A group of patients have been highlighted that are unable to use inhalers following instructions and this needs further audit.
Abstract 5054: Apolipoprotein B, but not Low-Density Lipoprotein Cholesterol is Associated with Coronary Atherosclerosis Beyond Total Cholesterol in Diabetics and Non-Diabetics
Authors: Seth S Martin, Atif N Qasim, Daniel J Rader, Muredach P Reilly
Journal: Circulation (2008)

Introduction: Accumulating evidence suggests that apolipoprotein B (apoB) is superior to low-density lipoprotein cholesterol (LDL-C) in prediction of cardiovascular events. Yet, an important outstanding question is whether apoB, relative to LDL, is an enhanced marker for subclinical atherosclerosis, particularly in diabetics where LDL levels may underestimate atherogenic lipid burden due to increased proportion of small, dense LDL. Hypothesis: We hypothesized that plasma apoB would be a better predictor than LDL-C of coronary artery calcification (CAC) scores in type 2 diabetics and non-type 2 diabetics. Methods: We performed cross-sectional analyses of asymptomatic Caucasians in (1) The Study of Inherited Risk of Coronary Atherosclerosis (434 men and 383 women; median age 48, non-diabetics) and (2) The Penn Diabetes Heart Study (580 men and 261 women; median age 60, type 2 diabetics). Results: Levels of apoB and LDL-C were correlated in diabetics (r=0.78, p&lt;0.001) and non-diabetics (r=0.77, p&lt;0.001). There was no association between LDL-C and CAC in diabetics. In non-diabetics, an association of LDL-C was lost after adjustment for total cholesterol. In contrast, after controlling for age, gender, statin therapy, and total cholesterol, levels of apoB were positively associated with CAC in diabetics [tobit regression ratio for 30 mg/dl increase in apoB 2.94 (95% CI 1.62 – 5.53), p=0.001) and had a more modest association with CAC in non-diabetics [1.67 (95% CI 1.16 – 2.32), p=0.005]. Conclusions: ApoB, but not LDL-C, predicted CAC scores, a measure of coronary atherosclerotic burden. The strength of this association was greater in diabetics than non-diabetics. Relative to LDL-C, plasma apoB levels may be particularly useful in assessing CVD risk in type 2 diabetes.
What Is the Initiating Mechanism of iAMP21 in Childhood B Cell Precursor ALL?.
Authors: Vikki Rand, Helen Parker, Lisa J Russell, Julie Irving, Lisa Jones, Dino Masic, Lynne Minto, Heather Morrison, Hazel Robinson, Claire Schwab, Paul Sinclair, Anthony V Moorman, Jonathan C Strefford, Christine J Harrison
Journal: Blood (2009)
Abstract 121: Inhibition of OX40 Ligand Suppresses the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice
Authors: Makoto Nakano, Kimio Satoh, Yoshihiro Fukumoto, Yoshitaka Ito, Naoto Ishii, Kazuo Sugamura, Hiroaki Shimokawa
Journal: Circulation (2007)

Background: Atherosclerotic lesions are characterized by infiltration of inflammatory cells (e.g. macrophages and T-lymphocytes), for which immunological mechanism(s) may be involved. Both soluble ...
Childhood Leukemia
Authors: C. M. Binger, A. R. Ablin, R. C. Feuerstein, J. H. Kushner, S. Zoger, Cynthia Mikkelsen
Journal: New England Journal of Medicine (1969)

TERMINAL illness makes a heavy impact upon all concerned, family and professionals. Particular effects of terminal illness and loss have been the subject of numerous studies.1 2 3 4 5 6 7 8 9 10 11 12 13 14 Lindemann8 points out that among adults the grief reaction is a syndrome with psychologic and somatic symptomatology, including somatic distress, a preoccupation with the image of the deceased, feelings of guilt, hostile reactions and the loss of previous patterns of conduct. How long the acute symptoms last seems to depend upon how quickly a person breaks his bonds with the one who has died, returns himself to his diminished human environment and forms new . . .
Linezolid in the treatment of multi- and extensively drug-resistance tuberculosis
Authors: Serge Borisov, Taisiya Ivanushkina, Natalia Litvinova, Yulia Garmash
Journal: European Respiratory Journal (2011)

Background:  Some known antibacterial drugs can be used as anti-tuberculosis agents. But all of them must initially be tested as a component of long-therm polychemotherapy. The most promising one, linezolid (Lz), is now in the spot-light of TB-experts [G.B. Migliori et al., Eur Respir J 2009; 34:387-393].   Aims:  To obtain data on efficacy and safety of Lz in the treatment of multi- (MDR) and extensively (XDR) drug-resistance tuberculosis (TB).   Methods:  The prospective unblinded non-randomized one-centered study, includes 35 pulmonary TB pts (18-71 y.o., 21 m and 14 f); MDR in 19 pts (7 new and 12 re-treated), XDR in 16 (3 and 13). Lz (600 mg q.d.) was included in treatment regimen, tailored by drug susceptibility tests, as 4th, 5th or 6th drug for 4-20 weeks. XDR was the strict indication for Lz, MDR - only if found impossible to create the adequate chemotherapy regimen (min 4 drugs) due to intolerance and/or resistance to second-line drugs.   Results:  After 4 weeks of treatment in all cases the evident resolution of clinical and X-ray symptoms was obtained. The sputum smear negativation totally score 85,7% (30 pts): 73,3% after 8 week, additional 6,7% after 12 weeks and 3,3% else after 16 week. The severe side-effects, attributed to Lz, occurred in 2 pts (5,7%): peroneal neuropathy and obstinate vomiting. Anemia, thrombocytopenia were not registered.   Conclusion:  The regimens included L (min 8 week) are high-effective in MDR and XDR TB in spite of long-term ineffective previously treatment. The Lz safety is quit well over a period of 8-16 weeks. Lz must be considered as a drug of choice after obtaining more accurate information on optimal length of administration, taking into account its high price.
Abstract 1820: Derivation of Multipotent Stem Cells from Epigenetically Modified Endothelial Progenitor Cells
Authors: Rajasingh Johnson, Prasanna Krishnamurthy, Erin Lambers, Haruki Sekiguchi, Catherine J David, Tina Thorne, Gangjian Qin, Douglas W Losordo, Raj Kishore
Journal: Circulation (2008)
Abstract 9379: Biomarkers of Aortic Stenosis Severity
Authors: Joseph L Blackshear, Robert E Safford, Steven Ung, Juna Misiri, Gretchen S Johns, Gabriel B Mufuka, Pragnesh P Parikh, Malik A Al-Omari, Dong Chen
Journal: Circulation (2011)

Aortic stenosis (AS) requires repeat assessments to optimally time intervention. The utility of laboratory tests to complement clinical and hemodynamic assessments has not been established. We assessed clinical, echocardiographic, and laboratory data in 76 patients with AS or heart valve replacement (HVR), age 77 years, 37% women. Laboratory assessments included von Willebrand factor (VWF) antigen, activity, (Act/Ag, normal &gt; 0.8), VWF multimer distribution (abnormal=loss of highest molecular weight multimers=Mult+), brain natriuretic peptide (BNP, abnormal &gt; 155 pg/ml=BNP+), and platelet function analyzer 100 collagen-ADP closure time (PFA, normal &lt; 121 seconds). Table: Coefficients of correlation, r, and F statistic. Chi-square, and probability. Correlation of BNP to mean gradient in patients with GFR&gt;60 remained poor, r=0.29, while for PFA r = 0.65. Median (IQR) for PFA and BNP for mild, moderate, and severe AS and HVR are shown below. VWF multimers were abnormal in 3/14 mild AS, 6/14 moderate AS, 22/25 severe AS and 4/23 HVR patients. The severity of AS was most strongly associated with VWF multimer abnormality and prolonged PFA closure time, weakly with BNP, and not with VWF Act/Ag. Conclusion: Among various laboratory measures, PFA and VWF multimers are strongly associated with AS severity, and may merit assessment as complementary diagnostic and prognostic biomarkers in AS.
Novel Phenotypic and Genetic Analysis of T-Cell Prolymphocytic Leukemia (T-PLL)
Authors: Henan Zhang, Esteban Braggio, Jaime Davila, Andrew L. Feldman, Timothy G. Call, Thomas E. Witzig, Yi Lin, Charla Secreto, Mrinal M. Patnaik, James R Cerhan, Sameer A. Parikh, Saurabh Baheti, Wei Ding
Journal: Blood (2014)
Significance of computed tomography in diagnostic of pleural content and the choice of the method of surgical treatment
Authors: Marina Rusetskaya, Vladimir Petukhov
Journal: European Respiratory Journal (2011)

Introduction:  The authors have aimed at stating more precisely the value of Haunsfields units using computed tomography in case of acute, subacute and chronic empyema, comparing these data with the results of morphologic investigation of operation material.   Goal of work:  To evaluate the possibility of beam diagnostics for determining the degree of chronic pleural effusions and the choice of the optimal method of surgical treatment.   Methods:  Case histories of 40 patients with pleural effusions treated at the thoracic department of Vitebsk Regional Hospital. All patients were divided into two groups.   Results:  On the scans of the first group patients there was the content of the pleural cavity with slightly irregular contours, areas of gas, pleural thickening (mesh structure), the mean attenuation of effusion ranged from +13 HU up to + 27HU due to the liquid, gas and organized components.  Patients of the second group had tomograms with described jagged contours of the pleural content, pleural thickening, the higher number and bigger size of air inclusions (flushing gas bubbles). The value of the mean of pleural content increased to +35 HU.  All patients of the first group had thoracoscopic surgical treatment.  The patients of the second group were operated on by open decortication.   Conclusions:  1. Computer tomography provides the opportunity to differentiate accurately enough the density of the pleural content and evaluate it in Hounsfield units.  2. Preoperative assessment of the nature of pleural content gives the opportunity of choice of surgical intervention, adequate to the nature of the inflammatory process.
Abstract 2586: Tricuspid Valve Repair During Left Ventricular Assist Device Insertion
Authors: George Comas, Kyle J Glithero, Tariq Naseem, Azam Jan, Yoshifumi Naka
Journal: Circulation (2007)

Purpose Right ventricular (RV) failure is associated with significant post-operative morbidity and mortality after left ventricular assist device (LVAD) insertion. Concomitant tricuspid valve repair (TVR) in the setting of tricuspid regurgitation (TR) is frequently performed to improve RV function after LVAD insertion. This study compared outcomes of patients with TR after LVAD insertion with and without TVR. Methods This was a retrospective case control study of 70 patients with matched degrees of TR undergoing LVAD implantation from 2000 to 2006 (Heartmate1, Heartmate2, DeBakey MicroMed). The TVR group consisted of patients undergoing LVAD insertion with TVR (n=24). The control group consisted of patients undergoing LVAD insertion without TVR (n=46). TR was quantified as 0 (none) to 4+ (severe) on echocardiography preoperatively and postoperatively. RV dysfunction score was defined as 0 (none), 1 (mild), 2 (moderate), or 3 (severe) on echocardiography. Postoperative clinical parameters, complications, and outcomes were evaluated. Results The TVR group and control group were similar in age (55y±15 vs 53y±12 respectively), gender distribution (18/24 male vs 42/46 male), ejection fraction (16%±5 vs 16%±6), LVAD score (preoperative measure of risk assessment 0–10), TR, mean PAP, CVP, and peak RV systolic pressure. In the TVR group, TR decreased from 2.0±0.8 to 0.7±0.5 post-operatively (p&lt;0.001). In the control group, TR also decreased from 2.2±0.7 to 1.3±0.8 (p&lt;0.001). In the TVR group, RV dysfunction score fell from 2.1±0.6 to 1.4±1.0 (p=0.01). In the control group, RV dysfunction score fell from 2.1±0.8 to 0.8±1.1 (p=0.049). Bypass time was higher in the TVR group (124±33min vs 66±46min). Incidence of acute renal failure (ARF) was lower in the TVR group (OR 0.2, p=0.02). There were no differences between the two groups regarding need for post-operative RVAD, early extubation, ICU LOS, bridge to transplant rate, or 30 day mortality. Conclusion Patients with TR requiring LVAD insertion had no improved survival when TVR was performed simultaneously. Bypass time was prolonged when TVR was performed. Patient groups with and without TVR had similar decreases in TR and improvement in RV dysfunction. Incidence of ARF was lower in the TVR group.
Abstract 2688: Automated Rhythm Analysis To Reduce Pauses During Cardiopulmonary Resuscitation
Authors: Joseph L Sullivan, Robert G Walker, Isabelle L Banville, Thomas D Rea, Fred W Chapman
Journal: Circulation (2008)

Background : Pauses in cardiopulmonary resuscitation (CPR) for Automatic External Defibrillator (AED) ECG analysis may adversely affect cardiac arrest resuscitation. Thus, approaches that analyze the ECG rhythm during CPR may improve outcomes. We developed and tested an Analysis During CPR (ADC) algorithm to determine if it would meet the American Heart Association recommended 90% sensitivity for coarse (&gt;0.2 mV peak-peak) ventricular fibrillation (VF) and 95% specificity for non-shockable rhythms. Methods : Defibrillator ECG and impedance recordings from 162 patients were retrospectively gathered from 3 EMS systems. 1047 15-second CPR-artifacted segments (274 coarse VF + 773 non-shockable) were identified for analysis; their artifact and rhythm distributions reflect those found in the 162 patients. Each CPR artifacted segment was paired with an adjacent segment free of CPR artifact for reference. Independent reviewers manually annotated and verified Shock/No-Shock rhythm designations blinded to the ADC determination. The ADC algorithm automatically classified each segment into categories of Shock/No Shock/Pause CPR For Clean Analysis, where the last category is segments recognized by the ADC as too noisy for accurate Shock/No Shock determination. In those situations the device would revert to the current approach of a CPR pause for AED rhythm analysis. Results : Of the 1047 CPR-artifacted segments, the ADC recommended to “Pause CPR For Clean Analysis” in 10% (n=109), including 4.4% of VF segments (12/274) and 12% (97/773) of non-shockable segments. Of the 938 remaining segments, the ADC correctly identified VF in 97% (sensitivity: 255/262) and correctly identified nonshockable rhythms in 96% (specificity: 650/676). Corresponding positive and negative predictive values were 91% and 99% respectively. Conclusions : The ADC is the first algorithm for automated ECG rhythm analysis during ongoing CPR that has been demonstrated to meet the existing AHA sensitivity and specificity recommendations designed for traditional rhythm analysis during hands-off pauses. Incorporation of this algorithm into an AED may eliminate about 90% of analysis pauses without compromising analysis accuracy and in turn may improve the likelihood of resuscitation.
Diabetic Therapy, With Special Reference to the Newer Remedies
Authors: Arthur A. Herold
Journal: Annals of Internal Medicine (1928)

Article1 September 1928Diabetic Therapy, With Special Reference to the Newer RemediesARTHUR A. HEROLD, M.D., F.A.C.P.ARTHUR A. HEROLD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-3-269 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe literature of today is teeming with articles on diabetes mellitus and especially with its therapy; there is probably no subject which has engaged the thoughts of a higher class of medical minds than this one. Such leaders as Allen, Joslin, Wilder and Woodyatt in this country; Banting, MacLeod and Campbell in Canada; and von Noorden, Minkowski, Cammidge and others abroad demonstrate, by their unceasing interest, not only that the riddle of diabetes is fascinating, but that it will be solved! By this, I mean that, whereas, by various methods of therapy, which we shall detail in this paper, the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Shreveport, Louisiana*Read before the American College of Physicians at the Annual Clinical Session, March 8, 1928, New Orleans, La. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1928Volume 2, Issue 3Page: 269-274KeywordsDiabetes mellitus ePublished: 1 December 2008 Issue Published: 1 September 1928 PDF downloadLoading ...