tbuckley/cabot-search huggingface dataset:
Abstract 20283: Calmodulin Kinase and Protein Kinase C Mediate the Effect of Increased Intracellular Calcium to Augment Late Sodium Current in Ventricular Myocytes
Authors: Jihua Ma, Wei Wan, Peihua Zhang, Lin Wu
Journal: Circulation (2010)

Objective:  An increase in intracellular calcium concentration ([Ca 2+ ] i ) leads to augmentation of late sodium current (late I Na ) by activating Ca 2+ -calmodulin-dependent protein kinase II (CaMK-II). The objective of this study was to confirm our hypothesis that both CaMK-II and protein kinase C (PKC) are the signaling molecules whose activation result in increased late I Na  in the presence of an increased [Ca 2+ ] i.    Methods:  Whole-cell and open-cell patch clamp techniques were used to record late I Na  in rabbit ventricular myocytes dialyzed with pipette solutions containing various concentrations (0.1, 0.3 and 0.6 μM) of [Ca 2+ ] i  in the absence and presence of CaMK-II (KN-93), PKC (bisindolylmaleimide, Bim) and MAPK (U0126) inhibitors in the bath solution.   Results:  Increases in [Ca 2+ ] i  from 0.1 to 0.6 μM resulted in an augmentation of late I Na  from 0.30 ± 0.03 to 0.45 ± 0.03 pA/pF (n=8–10, p +  channel open probability from 0.0067 ± 0.0009 to 0.0621 ± 0.0047 and prolongation of channel mean open-time. In the presence of 0.6 μM [Ca 2+ ] i,  either KN-93 (10 μM) or Bim (2 μM) decreased late I Na  by 33.3 % and 60.0 % from 0.45 ± 0.03 and 0.44 ± 0.02 to 0.40 ± 0.04 and 0.36 ± 0.03 pA/pF, respectively (n=8 and 10, p 2+ ] i ). A combination of KN-93 (10 μM) and Bim (2 μM) completely reversed the increase in late I Na  induced by 0.6 μM [Ca 2+ ] i  from 0.46 ± 0.03 to 0.30 ± 0.03 pA/pF (n=8, p Na  from 0.30 ± 0.05 to 0.39 ± 0.02 pA/pF (n=10, p Na  in the presence of increased [Ca 2+ ] i  levels.   Conclusions:  Both CaMK-II and PKC are involved in the pathway by which an increased [Ca 2+ ] I  leads to augmentation of late I Na  in rabbit ventricular myocytes.
Clonazepam treatment of tardive dyskinesia: a practical GABAmimetic strategy
Authors: Gunvant K. Thaker, James A. Nguyen, Milton E. Strauss, Richard Jacobson, Bruce A. Kaup, Carol A. Tamminga
Journal: American Journal of Psychiatry (1990)

Because of the efficacy of specific gamma-aminobutyric acid (GABA) agonists in tardive dyskinesia, the authors tested the benzodiazepine clonazepam in a 12-week, double-blind, placebo-controlled, randomized crossover trial in 19 chronically ill patients with tardive dyskinesia who were being treated with neuroleptics. They found a 35% decrease in dyskinesia ratings with clonazepam treatment. The six patients with predominantly dystonic symptoms showed greater benefit than the 13 patients with predominantly choreoathetoid dyskinesias. Tolerance developed to the antidyskinetic effect of clonazepam in the five patients whose long-term use of the drug was followed, but a 2-week clonazepam-free period recaptured its antidyskinetic effect.
Abstract 14752: Clot-targeting Of CD39 Through Genetic Fusion To An Activated-platelet Specific Single-chain Antibody Provides Efficient Inhibition Of ADP Receptor-mediated Platelet Activation Without Systemic Platelet Inhibition
Authors: Jan David Hohmann, Stefanie Krajewski, X Wang, Carly Selan, Andreas Straub, Harshal Hanumant Nandurkar, Christoph Eugen Hagemeyer, Karlheinz Peter
Journal: Circulation (2011)

CD39, a NTPDase with strong antithrombotic properties, has previously been shown to be protective in models of stroke, transplantations, pulmonary embolism and myocardial infarction by hydrolyzing/...
Association Of Large Granular Lymphocytic Leukemia (LGL) With B-Cell Lymphoproliferative Disorders
Authors: Alan P. Z. Skarbnik, Craig A. Portell, Jaroslaw P. Maciejewski, Ramon V. Tiu, Brad Pohlman, Manuel G. Afable, Anjali S. Advani, Robert M Dean, Brian T. Hill, Leonard J. Horwitz, Deepa Jagadeesh, Alan E. Lichtin, Christy Samaras, Mikkael A. Sekeres, Michael Millenson, Mitchell R Smith
Journal: Blood (2013)
THE NECESSITY OF CERTAIN CRITERIA FOR THE DIAGNOSIS AND CURE OF RHEUMATOID ARTHRITIS
Authors: Russell L. Cecil
Journal: Annals of Internal Medicine (1937)

Article1 October 1937THE NECESSITY OF CERTAIN CRITERIA FOR THE DIAGNOSIS AND CURE OF RHEUMATOID ARTHRITISRUSSELL L. CECIL, M.D., F.A.C.P.RUSSELL L. CECIL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-4-637 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPerhaps the most important problem which confronts a young medical organization such as the American Rheumatism Association is the proper orientation of the Society in the field which it proposes to cover. This question has already been attacked in part by this group. In the first place we decided that we would not confine ourselves strictly to the matter of arthritis, but would cover the whole field of rheumatism, including rheumatic fever. Our next task is to attack the problem of nomenclature, and what a difficult problem it is! The English have already made a brave effort in this direction,...Bibliography1. A Report on Chronic Arthritis, Reports on Public Health and Medical Subjects, British Ministry of Health, London, No. 52, 1928. Google Scholar2. DAWSON MH: A comparative study of subcutaneous nodules in rheumatic fever and rheumatoid arthritis, Jr. Exper. Med., 1933, lvii, 845-858. CrossrefGoogle Scholar3. CECILNICHOLLSSTAINSBY RLEEWJ: The etiology of rheumatoid arthritis, Am. Jr. Med. Sci., 1931, clxxxi, 12. CrossrefGoogle Scholar4. DAWSONOLMSTEADBOOTS MHMRH: Agglutination reactions in rheumatoid arthritis, Jr. Immunol., 1932, xxiii, 187. Google Scholar5. BLAIRHALLMAN JEFA: Streptococcal agglutinins and antistreptolysins in rheumatoid (atrophic) arthritis, Jr. Clin. Invest., 1935, xiv, 5. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*President's Address, read before the Fourth Annual Meeting of the American Rheumatism Association at Atlantic City, New Jersey, June 7, 1937. Received for publication July 9, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRecent Researches on Arthritis and Rheumatism in the United States 1 October 1937Volume 11, Issue 4Page: 637-642KeywordsRheumatic feverRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 October 1937 PDF downloadLoading ...
De la Tuberculose Mammaire.
Authors: Adrien-W. Roux
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 14702: Tranilast Prevents Development of Substrates for Atrial Fibrillation in a Canine Model of Atrial Tachycardia and Rapid Ventricular Response
Authors: Yosuke Nakatani, Kunihiro Nishida, Masao Sakabe, Tamotsu Sakamoto, Yoshiaki Yamaguchi, Jotaro Iwamoto, Koichi Mizumaki, Akira Fujiki, Hiroshi Inoue
Journal: Circulation (2011)

Background: Tranilast is an anti-allergic agent which has multiple effects including inhibition of collagen synthesis. Previous studies reported tranilast prevents cardiac fibrosis; however, its ef...
P1229 : Liver transplantation for progressive familial intrahepatic cholestasis type 3 (MDR3 disease) presenting in the 5th decade of life
Authors: H. Elsiesy, F. Abaalkhail, S. Yousif, M. Al Sebayel, H. Alhussaini, M. Alquaiz, D. Broring, W. Alhamoudi, M. Shagrani
Journal: Journal of Hepatology (2015)
307. Engineering Recombinant AAV Vectors for More Efficient and Restricted Gene Expression in the CNS after Systemic Administration
Authors: Benjamin E. Deverman, Bryan Simpson, Piers Pravdo, Abhik Banerjee, Paul H. Patterson
Journal: Molecular Therapy (2014)

We previously demonstrated that delivery of the cytokine
leukemia inhibitory factor (LIF) to the brain by recombinant
adenovirus enhances oligodendrocyte progenitor cell proliferation and remyelination in a mouse model of multiple sclerosis (MS).
Measurement of Outcome in Rheumatic Diseases
Authors: V Wright
Journal: Journal of the Royal Society of Medicine (1985)

In the assessment of outcome in rheumatic diseases a number of factors must be taken into account. It is important to make an accurate diagnosis, so that the response to treatment is not confused by heterogeneity of the population. The meaning of outcome needs to be defined. The quality of life over a prolonged period is just as important as the ultimate outcome. Subjective symptoms are important to the patient. Pain is the most important, followed by disability and then stiffness. Despite attempts to produce numerical values for pain, particularly visual analogue scales, patients' accuracy in recalling pain experienced more than an hour previously is dubious. In an attempt to quantify this aspect we have measured disturbance of sleep by changes in the EEG and in the motility of the patient. Objective clinical measures are desirable for accuracy. Arthrographs of the knees and metacarpophalangeal joints have produced useful data for physical stiffness. It is doubtful, however, whether they truly reflect the subjective stiffness of which the patient complains. That is more likely to be due to limitation of motion. Grip strength is commonly measured by a pneumatic dynomometer, but a pinch/hand grip analyser promises to give more extensive information. Active movement has been measured goniometrically. The value of electrogoniometers should be enhanced by telemeterization of the apparatus. Passive movement has been measured with a hyperextensometer in patients with hypermobility. Ligamentous laxity of the knee can be measured on the Leeds Knee Analyser and differentiates collateral ligament damage and anterior cruciate ligament damage. Laboratory variables are important in a patient model system in which potential antirheumatoid drugs can be screened and their mechanism of action investigated. Correlation matrices separate second-line agents from NSAIDs. Although mini-matrices have been produced, it would not appear that any single biochemical test will suffice to differentiate these two classes of drugs. A therapeutic index, in which the efficacy is expressed as a ratio of the toxicity of the drug, is important in determining its value. The nearest we can get to serial assessment of the pathological changes in the joint is by X-ray assessment. Changes radiologically correlate to some extent with the height of the ESR, and their progress with changes in the ESR. Functional impairment is important to the patient in the long term, and the Disability Index devised by the Stanford group commends itself for extensive long-term studies.
Abstract 1369: A New Murine Model of Diabetic Cardiomyopathy: The Female Leptin-Deficient, Black and Tan Brachyuric Mouse
Authors: Kevin D O'Brien, Elina Minami, Jinkyu Kim, Tomasz Wietecha, Kelly Hudkins, Thomas O McDonald, Charles E Alpers
Journal: Circulation (2009)

Objective: Patients with diabetes have a 2-fold increased risk for congestive heart failure (CHF) and non-ischemic cardiomyopathy. Identifying mechanisms underlying diabetic cardiomyopathy would be...
Hemorrhoids
Authors: Deborah Tolmach Sugerman
Journal: JAMA (2014)

HemorrhoidsHemorrhoids are bulging blood vessels in or near the rectum or anus.Hemorrhoidsaresocommonthatmostpeoplehavethematsomepoint in their lives.They may develop inside the anus (but can protrude outside)ordevelopoutsidetheanusandbecoveredbyskin.Althoughhemorrhoidscanbepainful,theyrarelycauselong-termhealthproblemsand are not associated with cancer.They sometimes result in blood in the stool, but this can also occur with colon or rectal cancer.
Transcatheter Closure of Perimembranous Ventricular Septal Defects
Authors: Gianfranco Butera, Mario Carminati, Massimo Chessa, Luciane Piazza, Angelo Micheletti, Diana Gabriella Negura, Raul Abella, Alessandro Giamberti, Alessandro Frigiola
Journal: Journal of the American College of Cardiology (2007)
A Mallory–Weiss tear treated with transarterial embolization complicated by disseminated intravascular coagulation
Authors: Youn Choi, Moo Park, Seun Park, Won Moon, Sung Kim, Hye Kwon, Jae Kim, Seong Kang
Journal: Endoscopy (2015)

A 53-year-old woman presented to the emergency department with persistent vomiting followed by hematemesis. She reported heavy alcohol consumption on the previous day. Her blood pressure was 100/80 mmHg and her pulse rate was 131 beats/minute. The results of laboratory studies revealed a hemoglobin level of 8.0 g/dL.
Abstract 15337: Hypercholesterolemia is a Risk Factor for Aortic Bioprosthetic Valve Degeneration
Authors: haifa mahjoub, Patrick Mathieu, Mario Senechal, Eric Larose, Jean-Gaston Dumesnil, Jean-Pierre Despres, Philippe Pibarot
Journal: Circulation (2011)

BACKGROUND. Structural valve degeneration (SVD) is the major cause of bioprosthetic valve failure. Recent retrospective studies have reported an association between atherosclerotic risk factors and...
A new prognostic classification scheme with treatment guidelines for Asian patients with hepatocellular carcinoma (HCC): The Hong Kong Combined Liver Cancer (HKCLC) classification.
Authors: Y. F. Tang, T. Yao, C. C. Yau, S. T. Fan, R. T. P. Poon
Journal: Journal of Clinical Oncology (2011)

4067 Background: HCC patients in Asia mostly have different etiologies and have different treatment algorithm when compared with their Western counterparts. Despite the wide use in Western countries, the Barcelona Clinic Liver Cancer (BCLC) staging may not fit in the management of Asian patients. We aim to develop a new prognostic classification scheme with treatment guidelines for Asian HCC patients. Methods: HCC patients treated at the Department of Surgery, Queen Mary Hospital between 1995 and 2008 were included. The scheme was developed by both statistical methodology and clinical judgment. Four established prognostic factors, namely ECOG PS, Child-Pugh grade, tumor status and presence of extrahepatic venous invasion/metastasis, were selected in building the scheme. A scoring system which assigns “points” to each category of these 4 factors was developed using Cox regression on overall survival. The points and combined scores were referred to stratify patients to different staging with specific treatment recommendations. Results: 3,617 patients were identified. The scheme stratifies patients to stages I to V with distinct overall survival outcomes. Selected patients had benefited from more aggressive treatments than what were recommended in BCLC. In patients who were classified as stage B in BCLC but I/II in HKCLC, the survival benefit of radical curative therapies over TACE was substantial (5-year survival probability: 0.479 vs 0.175; P<0.0001 by log-rank test). Similarly, in patients who were classified as stage C in BCLC but I/II in HKCLC, the survival benefit of radical curative therapies over systemic therapy was even more pronounced (5-year survival probability: 0.484 vs 0; P<0.0001 by log-rank test). Furthermore, in patients who were classified as stage C in BCLC but III in HKCLC, the survival benefit of TACE over systemic therapy was also significant (3-year survival probability: 0.087 vs 0.011; P<0.0001 by log-rank test). Conclusions: The HKCLC scheme may be able to identify patients suitable for treatments more aggressive than BCLC’s recommendations and thus yield a better survival outcome.
Impact of bronchodilator on pulmonary function and exercise tolerance in LAM
Authors: Bruno Baldi, Suzana Pimenta, André Albuquerque, Ronaldo Kairalla, Milena Suesada, Vanessa Pavezi, Fabiane Polisel, Carlos Carvalho
Journal: European Respiratory Journal (2011)

Rationale: Reduced exercise capacity in LAM patients is still slightly understood. As many patients have airflow obstruction and dynamic hyperinflation (DH) (abstract 4576, ATS 2010), bronchodilator (Bd) might be a plausible option.  Objective: To evaluate the improvement with inhaled salbutamol in resting airflow obstruction, exercise tolerance and reversal of DH.  Methods: 37 LAM patients (mean age 41±10 years; FEV1 79±24%pred; DLCO 68±24%pred) performed incremental CPET (incCPET) on cycle; decrease ≥ 10% in IC defined DH. So, a randomized double-blind crossover study (inhaled salbutamol x placebo) was done. After each intervention, they performed lung function (PFT) and endurance CPET (endCPET) (75% max work-rate). Exercise duration, Borg scale and IC were compared at isotime in endCPET after Bd and placebo.  Results: 19 patients (51%) showed DH in incCPET, with max work-rate lower in DH group (93 × 115W, p=0.16) and higher values in Borg dyspnea (7 x 5, p=0.02). Compared to non-DH, DH group had lower DLCO (56 x 81%pred, p=0.001), lower FEV1 (76 x 89%pred, p=0.002) and greater RV/TLC (0.43 x 0.29, p  Conclusion: DH during exercise is frequent in LAM and is associated with resting airflow obstruction, reduced exercise capacity and higher breathlessness. Short-term Bd may exert a potential beneficial effect in DH patients.
American data refute ultraviolet hypothesis
Authors: R. Newton
Journal: BMJ (1995)

incidence of both melanoma and non-melanoma skin cancer in people with pigmented skin is several times lower than that in people with less pigmented skin.2How do the authors explain an apparent lack of association of lymphoma and leukaemia with skin colour?The authors' reasoning is based on two assump- tions: that the incidence of skin cancer can be used as a marker of exposure to ultraviolet radiation and that immunosuppression has a dominant role in the pathogenesis of cancer induced by ultraviolet radiation.Both assumptions may be false.Al- though ultraviolet radiation has an unequivocal role in the development of skin cancer, the patho- genesis of skin neoplasms is multifactorial.This is shown by the fact that exposure to the sun increases the relative risk of melanoma by only a factor of two to five, which is not impressive in comparison with the 85-1269 times higher risk in people with two family members with melanoma.'Moreover, recent evidence suggests that, in the pathogenesis of skin cancer, mechanisms other than immunosuppression are relevant, such as mutagenesis and suppression of apoptosis induced by ultraviolet radiation.Factors other than expo- sure to ultraviolet radiation-for example, genetic predisposition-probably better explain the association between skin cancer and the occurrence oflymphoma and leukaemia.
The tropical disease research programme has a coherent plan
Authors: S M Macleod
Journal: BMJ (1995)

EDITOR,—At times when reading Fiona Godlee's articles analysing the performance of the World Health Organisation I have had the feeling that journalistic enthusiasm for piercing criticism has taken precedence over the need for constructive suggestion. A case in point is the article on WHO fellowships,1 which refers to a report that I wrote in 1993 …
Lead Poisoning in the English Books of Trades
Authors: Carl Vernon Weller
Journal: Annals of Internal Medicine (1930)

Article1 July 1930Lead Poisoning in the English Books of TradesCARL VERNON WELLER, M.S., M.D.CARL VERNON WELLER, M.S., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-1-81 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Books of Trades attempt to give "Parents, Guardians and Trustees, as well as the Youths themselves, intended for Trades and Business, not only a general Description of almost all Handicrafts, Trades and Employs in Vogue, but also such Particulars of them, as will enable both the one and the other to form a tolerable Judgment which of them all may be most agreeable, and best answer their purpose." (Preface to 'A General Description of All Trades', 1747). If these prefatory promises were completely fulfilled the Books of Trades ought to reflect the state of knowledge of occupational disease at... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*From the Department of Pathology, University of Michigan, Ann Arbor, Michigan.†Read before the American Association of the History of Medicine, May 7, 1930. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1930Volume 4, Issue 1Page: 81-93KeywordsAdolescentsHistory of medicine ePublished: 1 December 2008 Issue Published: 1 July 1930 PDF downloadLoading ...
The “Welcome to Medicare” visit: a chance to raise the profile of prevention among older adults
Authors: Steven H Woolf, Ashley B Coffield
Journal: BMJ (2005)

A mericans receive only half of recommended clinical preventive services—screening tests, counseling about health behaviors, immunizations—due to deficiencies in the delivery system that extend to therapeutic services as well.1 Gaps in preventive care are a special concern, however, because of their importance in maintaining the health of the population and in stemming the rising incidence and costs of chronic diseases.

The failure of older adults to receive preventive services is exacerbated by special issues. Many seniors live with the misconception that it is too late to benefit from stopping smoking or physical activity, although science suggests otherwise.2,3 A longstanding impediment has been lack of coverage of preventive services under the Medicare program. The legislation that created Medicare in 1964 authorized coverage only of diagnostic and treatment services, making it necessary for Congress to pass individual laws to provide coverage for Pap smears and other preventive services.4

A string of such bills, enacted between 1980 and 2003, has now expanded Medicare coverage to include screening for breast cancer, colorectal cancer, cervical cancer, prostate cancer, osteoporosis, hyperlipidemia, diabetes, and glaucoma, as well as pneumococcal, influenza, and hepatitis B immunizations. But problems persist. For example, some preventive services …
Safety of intracoronary autologous bone marrow cells transplantation in chronic Chagas disease dog model
Authors: J. A. Assad, F. A. Tuche, S. A. Silva, R. C. Moreira, R. V. Branco, L. Carvalho, M. G. Sousa, A. Camacho, R. Borojevic, H. Dohmann
Journal: Circulation (2005)
Abstract 14881: Prepubertal Blockade of Angiotensin II Type 1 Receptor Causes Long-term Therapeutic Effects through Sustained Enhancement of Renal ATRAP Expression in Dahl Salt-sensitive Hypertensive Rats
Authors: Kouichi Tamura, Toru Dejima, Hiromichi Wakui, Atsu-ichiro Shigenaga, Akinobu Maeda, Tomohiko Kanaoka, Masato Ohsawa, Sona Haku, Miyuki Matsuda, Mai Yanagi, Hiroshi Mitsuhashi, Satoshi Umemura
Journal: Circulation (2010)

Activation of angiotensin II (Ang II) type 1 receptor (AT1 receptor) signaling plays a pivotal role in the pathogenesis of hypertension and renal injury. We cloned a novel molecule interacting with...