tbuckley/cabot-search huggingface dataset:
LEAD AND MULTIPLE SCLEROSIS
Authors: Harry V. Warren
Journal: JAMA (1934)

It has been suggested that lead may be a cause of multiple sclerosis, but confirmation of this hypothesis is difficult to obtain as lead is so widely present both in the environment and in many human tissues.In this study 22 patients with multiple sclerosis were compared with 22 controls. Lead levels in the blood of the patients were not higher and urinary lead levels in the patients before and after a single dose of penicillamine did not provide evidence to support the hypothesis that lead may cause the disease.
Abstract 9322: Remnant Lipoproteinemia is a Predictor of Coronary Events in Patients with Coronary Artery Disease and Chronic Kidney Disease
Authors: Yukio Saito, Takamitsu Nakamura, Wataru Sugamata, Juntaro Deyama, Manabu Uematsu, Keita Sano, Daisuke Fujioka, Yoshinobu Kitta, Ken-ichi Kawabata, Jun-ei Obata, Kiyotaka Kugiyama
Journal: Circulation (2011)

Although triglyceride (TG) levels are increased in chronic kidney disease (CKD), the independence of high TG levels as a risk for coronary events remains debatable. We have previously shown that remnant lipoproteins, one of TG-rich lipoproteins, is a strong risk for future coronary events independent of low HDL-C levels and high LDL-C levels in patients with coronary artery disease (CAD). Thus, this study examined predictive value of remnant lipoproteins for coronary events in CAD patients with CKD. Methods: Fasting serum levels of remnant lipoproteins (remnant-like lipoprotein particles cholesterol; RLP-C) were measured by an immunoseparation method in 229 patients with CAD and CKD (estimated GFR &lt; 60 ml/min/1.73m 2 , excluding hemodialysis patients). All patients were prospectively followed up for a period of 18 months or until occurrence of one of following events: cardiac death, nonfatal myocardial infarction (MI), unstable angina requiring unplanned coronary revascularization or worsening heart failure requiring hospitalization. Results: During follow-up period, events occurred in 28 (37%) patients with higher levels of RLP-C (&gt; 5.0 mg/dL, 75 th percentile of the distribution) (5 cardiac death, 4 MI, 15 unstable angina, 4 heart failure), while events occurred in 18 (11.7%) patients with lower RLP-C levels (&lt; 5.0 mg/dL) (2 MI, 14 unstable angina, 2 heart failure) (p&lt;0.0001). In Kaplan-Meier analysis, higher RLP-C levels resulted in a higher probability for the development of coronary events than lower RLP-C levels (p &lt; 0.01). In multivariate Cox proportional hazards analysis, higher RLP-C levels were a significant predictor of coronary events (HR 1.8, 95%CI 1.3 - 6.9, p &lt; 0.01), that was independent of TG levels and the Framingham risk variables. In c -statistics, RLP-C levels had an incremental effect on the predictive value of the Framingham risk variables for coronary events (area under ROC curve: RLP-C + Framingham risks 0.83 vs. Framingham risks alone 0.75, p &lt; 0.01). Conclusions: High remnant lipoprotein levels are an independent predictor of coronary events in CAD patients with CKD. Assessment of remnant lipoprotein levels may be useful for risk stratification for coronary events in patients with CKD.
Abstract 16231: Endogenous TSP-1 Modulates the Hypertrophic and Fibrotic Response in the Pressure-Overloaded Heart
Authors: ying xia, Marcin Dobaczewski, carlos Gonzalez-Quesada, Na Li, Qi Tian, Leonarddo H Mendoza, Nikolaos G Frangogiannis
Journal: Circulation (2010)

The matricellular protein Thrombospondin (TSP)-1 is expressed following tissue injury and may regulate reparative responses by activating TGF-β, by suppressing angiogenesis, and by modulating infla...
Exposure to Bisphenol A and Phthalates during Pregnancy and Ultrasound Measures of Fetal Growth in the INMA-Sabadell Cohort
Authors: Maribel Casas, Damaskini Valvi, Ana Ballesteros-Gomez, Mireia Gascon, Mariana F. Fernández, Raquel Garcia-Esteban, Carmen Iñiguez, David Martínez, Mario Murcia, Nuria Monfort, Noelia Luque, Soledad Rubio, Rosa Ventura, Jordi Sunyer, Martine Vrijheid
Journal: Environmental Health Perspectives (2015)

Prenatal exposure to bisphenol A (BPA) and phthalates may affect fetal growth; however, previous findings are inconsistent and based on few studies.We assessed whether prenatal exposure to BPA and phthalates was associated with fetal growth in a Spanish birth cohort of 488 mother-child pairs.We measured BPA and eight phthalates [four di(2-ethylhexyl) phthalate metabolites (DEHPm), mono-benzyl phthalate (MBzP), and three low-molecular-weight phthalate metabolites (LMWPm)] in two spot-urine samples collected during the first and third trimester of pregnancy. We estimated growth curves for femur length (FL), head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), and estimated fetal weight (EFW) during pregnancy (weeks 12-20 and 20-34), and for birth weight, birth length, head circumference at birth, and placental weight.Overall, results did not support associations of exposure to BPA or DEHPm during pregnancy with fetal growth parameters. Prenatal MBzP exposure was positively associated with FL at 20-34 weeks, resulting in an increase of 3.70% of the average FL (95% CI: 0.75, 6.63%) per doubling of MBzP concentration. MBzP was positively associated with birth weight among boys (48 g; 95% CI: 6, 90) but not in girls (-27 g; 95% CI: -79, 25) (interaction p-value = 0.04). The LMWPm mono-n-butyl phthalate (MnBP) was negatively associated with HC at 12-20 pregnancy weeks [-4.88% of HC average (95% CI: -8.36, -1.36%)].This study, one of the first to combine repeat exposure biomarker measurements and multiple growth measures during pregnancy, finds little evidence of associations of BPA or phthalate exposures with fetal growth. Phthalate metabolites MBzP and MnBP were associated with some fetal growth parameters, but these findings require replication.Casas M, Valvi D, Ballesteros-Gomez A, Gascon M, Fernández MF, Garcia-Esteban R, Iñiguez C, Martínez D, Murcia M, Monfort N, Luque N, Rubio S, Ventura R, Sunyer J, Vrijheid M. 2016. Exposure to bisphenol A and phthalates during pregnancy and ultrasound measures of fetal growth in the INMA-Sabadell cohort. Environ Health Perspect 124:521-528; http://dx.doi.org/10.1289/ehp.1409190.
发热-乏力-大汗
Authors: 王健仰, 吴东, 范洪伟, 方卫纲
Journal: BMJ (2009)

患者女性，45岁，入院前1个月发热，体温最高39．5℃。伴畏寒、乏力、大汗，无寒战、咳嗽、腹痛、腹泻、尿频等。外院查白细胞（WBC）3．7×10^9／L，分类中性粒细胞（N）0．524，淋巴细胞（L）0．303，血红蛋白（Hb）142g／L，血小板（PLT）184×10^9／L。予头孢噻肟和青霉素治疗无效。
Is dysthymia a different disorder in the elderly?
Authors: D P Devanand, M S Nobler, T Singer, J E Kiersky, N Turret, S P Roose, H A Sackeim
Journal: American Journal of Psychiatry (1994)

This study evaluated elderly dysthymic patients in a late life depression clinic and compared their clinical features to previous findings in young adult dysthymic patients.Of 224 consecutive elderly outpatients, 40 (17.9%) met criteria for dysthymic disorder. A semistructured interview was used to obtain history, the Structured Clinical Interview for DSM-III-R--Patient Version and the Structured Clinical Interview for DSM-III-R Personality Disorders were used to make DSM-III-R diagnoses, and standard rating instruments for depression were administered.The gender distribution was equal and major stressors were common. The mean age at onset of dysthymia was 55.2 years (SD = 15.4), with an average illness duration of 12.5 years (SD = 14.2). Early onset (before 21 years of age) and secondary dysthymia were rare. A history of major depression earlier during the course of dysthymic illness, comorbid anxiety disorders, and personality disorders were relatively uncommon. Cross-sectionally, cognitive and functional symptoms were more prominent than vegetative symptoms.Dysthymia is not uncommon among depressed elderly outpatients who present for treatment. Elderly dysthymic patients differ from young adult dysthymic patients, who are mostly female with an early onset and who frequently have comorbid axis I and axis II disorders. Most elderly dysthymic patients do not appear to be young dysthymic patients who simply grew older, and the DSM-III-R subtyping of dysthymia into early/late onset and primary/secondary may not apply to the elderly. Further clinical studies of "pure" dysthymic disorder appear feasible in the elderly, and these are clearly needed.
Book: Blood and Bone
Authors: S. Goldbeck-Wood
Journal: BMJ (1999)

Eds Angela Belli, Jack Coulehan University of Iowa Press, £16.95, pp 224 ISBN 0877456380 Rating: ![Graphic][1]</img>![Graphic][2]</img> Why do some doctors write poems? In Poems Before and After Miroslav Holub wrote that a poem arises when there's nothing else to be done, as a last attempt at order when one can't stand disorder any longer: “Although poets are most needed when freedom, vitamin C, communications, laws and hypertension therapy are also most needed, a poem is not one of the last but one of the first things of man.” As a … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
Abstract 17098: Blood Pressure Response to Controlled Diesel Exhaust Inhalation in Human Subjects is Modified by Functional Variation in TRPV1
Authors: Kristen Cosselman, Ranjini M Krishnan, Assaf P Oron, Alon Peretz, Tim V Larson, Joel D Kaufman, Karen Jansen
Journal: Circulation (2011)

Background: Exposure to traffic-related air pollution is associated with increased risk of cardiovascular disease and mortality. Diesel exhaust (DE) inhalation is a model exposure, and we hypothesize that pollutants trigger acute cardiovascular events via neurogenic processes. We evaluated blood pressure (BP) response to DE and whether the effect was modified by genotype for the transient receptor potential receptor, vanilloid type 1 (TRPV1), a non-selective cation channel expressed in the lung and activated by noxious chemical stimuli. The t allele for the TRPV1 single nucleotide polymorphism rs8065080 at position 585 results in Ile substituting for Val, and has been associated with reduced nociception. Methods: Forty-seven non-smokers, age 18-49 with no prior cardiovascular or pulmonary disease, underwent controlled exposures to each condition [DE at 200 μ g/m 3 PM 2.5 and filtered air (FA)] for 120 minutes in a crossover experiment. Exposures were double-blind, randomized to order, and separated by at least 2 weeks. We measured BP pre-exposure, at 5 time points during exposure, and 3, 5, 7 and 24 hours from exposure start. We analyzed pressure change (from pre-exposure values) for each exposure to determine the difference between DE and FA. Results: Compared with FA, systolic blood pressure (SBP) increased at all time points measured during and after DE exposure (p=0.004); mean effect peaked 30 to 90 minutes after exposure began (3.9 mmHg, p=0.01). No effects were observed for heart rate or diastolic BP. SBP response varied by TRPV1 Ile585Val genotype, with t/t subjects showing the lowest SBP response to DE (see Figure). Conclusion: DE exposure was associated with a rapid increase in SBP, with a reduced response in subjects with the Ile-Ile variation of TRPV1. This suggests that TRPV1 activation by a component of DE may be a key step explaining observed vascular effects of air pollution, perhaps by initiating autonomic signaling or neurogenic inflammation.
Abstract 9224: Depletion of Mature B cells by Deletion of BAFF Receptor Reduces Atherosclerosis in ldlr Knockout Mice
Authors: Andrew P Sage, James E Harrison, Lauren A Baker, Leanne Masters, Dimitris Tsiantoulas, Christoph J Binder, Ziad Mallat
Journal: Circulation (2011)

Innate-like B1a cells may protect against atherosclerosis via production of natural anti-oxLDL IgM antibodies. However, we recently demonstrated that anti-CD20 antibody-mediated B cell depletion reduced murine atherosclerosis, suggesting some subsets of B cells could promote atherosclerosis. B cell activating factor (BAFF) and its cognate receptors, are important regulators of B cell survival and activation. Increased BAFF levels are associated with a number of autoimmune diseases. This study aims to characterise the effects of mature B cell loss on atherosclerosis. We analysed aortic root atherosclerosis, serum anti-oxLDL antibody levels and immune cell phenotypes in male ldlr-/- mice transplanted with control (WT) or BAFF receptor (BAFFR)-/- bone marrow and fed a high fat diet for 6 weeks. Ldlr/BAFFR-/- chimeric mice had significantly reduced levels of mature B cells (B220+ IgM+) in the spleen, blood, bone marrow and peritoneum, but no difference in peritoneal B1a cells (B220+ IgM+ CD11b+ CD5+). Despite a non-significant trend towards increased serum total cholesterol (6.65±0.72 g/l vs 6.03±0.72 in controls), aortic root atherosclerosis levels were reduced by 33% in ldlr/BAFFR-/- mice, an effect accompanied by a reduction in IgG but not IgM antibodies to malonaldehyde modified-LDL and reduced CD4+ T cell proliferation in vitro. However, there was no apparent difference in Treg levels or function, and no changes in blood Ly6C monocyte subsets. Splenic dendritic cells from ldlr/BAFFR-/- mice displayed reduced CD40 and MHC Class II expression, suggesting impaired activation in the absence of B cells. Deficiency in mature B cell levels reduced atherosclerosis and circulating levels of anti-oxLDL IgG, potentially linked to impaired pro-inflammatory dendritic cell maturation and T cell activation. These results support the notion that whereas B1a cells may protect against atherosclerosis by production of protective natural anti-oxLDL IgM antibodies, other B cell subsets could play pathogenic roles. This study provides important insight into the potential effects of therapies targeting B cells and/or BAFF on atherosclerosis.
Implantable Cardioverter-Defibrillator Therapy in Brugada Syndrome
Authors: Giulio Conte, Juan Sieira, Giuseppe Ciconte, Carlo de Asmundis, Gian-Battista Chierchia, Giannis Baltogiannis, Giacomo Di Giovanni, Mark La Meir, Francis Wellens, Jens Czapla, Kristel Wauters, Moises Levinstein, Yukio Saitoh, Ghazala Irfan, Justo Julià, Gudrun Pappaert, Pedro Brugada
Journal: Journal of the American College of Cardiology (2015)
Abstract 4090: Substrate Modification Using Electroanatomically-guided Linear Ablation During Sinus Rhythm To Treat Post-infarction Ventricular Tachycardia
Authors: Thomas Deneke, Bernd Lemke, Leif-Ilja Boesche, Bernd Calcum, Andreas Muegge, Thomas Lawo, Peter H Grewe
Journal: Circulation (2008)

Catheter ablation of ventricular tachycardia (VT) in the setting of ischemic cardiomyopathy can be performed to modify the underlying substrate. We evaluated the efficacy of a linear VT ablation procedure based on sinus rhythm (SR) substrate maps to treat ischemic VT in consecutive patients. Methods: In 110 consecutive patients with ischemic VT (56% not tolerated) catheter ablation was attempted. During SR left ventricular scar mapping was performed identifying scar tissue (bipolar voltages 1.5mV). Regionalization of VT-exit regions was performed based on pace-mapping within the scar border zone. Ablation was directed towards the identified exit region performing linear ablation along the scar border. ICD-holter interrogation was performed during follow-up. Results: A mean of 2.7±1.6 different VTs were inducible per patient (total 286). In 97% (107) of all patients (74% of all inducible VTs ablated: 213/286) the clinical VT was successfully ablated. In 68 patients (62%) no sustained monomorphic VT (complete success) was inducible at the end of the ablation procedure whereas in 39 patients (35%) VTs (partial success) were still inducible. Over a median follow-up of 12 months (6 –39) 88 (80%) patients were free from any ventricular arrhythmia. 19 successfully ablated patients had recurrences in between 6 to 36 months post intervention but the number of episodes treated by the ICD was significantly reduced (16±4 within 3 months (3±2) (p=0.02). No difference in patients with tolerated compared to non-tolerated VTs were detected (recurrences in 7/48 (15%) tolerated and 15/62 (24%) non-tolerated; p=0.13). There was a significant difference in freedom from any VT in patients with complete (88%) versus partial success (72%) (p=0.04). Conclusions: Substrate modification targeting only the scar-border zone including the VT exit site based on SR-maps is highly effective in suppressing the occurrence of a clinical VT in patients with remote myocardial infarction (97%). Based on the electro-anatomical findings complete freedom from any ventricular arrhythmia over a median of 1 year can be achieved in 80% of all patients. No difference in regard to freedom from any ventricular arrhythmia can be documented in patients with tolerated and non-tolerated VTs.
Abstract 14504: Outcomes After Spontaneous Coronary Artery Dissection: A Long-Term Single Center Experience
Authors: Marysia S Tweet, Sharonne N Hayes, Sridevi R Pitta, Sherezade Khambatta, Patricia J Best, Ryan J Lennon, Charanjit S Rihal, Rajiv Gulati
Journal: Circulation (2011)

Background: Spontaneous coronary artery dissection (SCAD) is a rare, non-atherosclerotic acute coronary event of uncertain etiology. Demographics, optimal treatment modalities and outcomes remain p...
Inflammatory subtypes of non-atopic asthma
Authors: J.C. de Groot, H. Storm, E.H. Bel, A. ten Brinke
Journal: European Respiratory Journal (2011)

Introduction: In asthma, several types of airway inflammation have been described (Simpson Respirology 2006), which may represent clinically different subtypes of asthma. Whether non-atopic asthma can also be divided into different subtypes according to airway inflammation is unknown.

Aim: To investigate whether different inflammatory profiles correspond with distinct clinical and functional characteristics in patients with non-atopic asthma.

Methods: In a cross-sectional study we included outpatients with non-atopic asthma and divided them into 4 types of airway inflammation. All patients filled out questionnaires (co-morbidity, ACQ, AQLQ, Sino-Nasal outcome Test (SNOT)) and underwent spirometry, blood tests, sputum induction and nasal endoscopy.

Results: 62 patients (90% adult onset) were included. We found no differences in BMI, questionnaires or spirometry. Differences between groups: see Table 1.

View this table:

Table 1





Conclusion: Almost all adult non-atopic asthma patients have their onset of asthma in adulthood. There are at least 2 distinct phenotypes: an eosinophilic phenotype, characterized by male gender, high levels of IgE and nasal polyps, and a neutrophilic phenotype associated with extra-pulmonary auto-immune diseases.

Implication: Fenotype specific therapies, that might improve outcome of non-atopic asthma, should be further evaluated.
Microarray Data Standards: An Open Letter
Authors: Catherine Ball, Alvis Brazma, Helen Causton, Steve Chervitz, Ron Edgar, Pascal Hingamp, John C. Matese, Helen Parkinson, John Quackenbush, Martin Ringwald, Susanna-Assunta Sansone, Gavin Sherlock, Paul Spellman, Christian Stoeckert, Yoshio Tateno, Ronald Taylor, Joseph White, Neil Winegarden
Journal: Environmental Health Perspectives (2004)
Abstract 10153: SIRT1 Activation Restores Cardioprotection in the Aged Heart Against Ischemia/Reperfusion Injury
Authors: Chao Tong, Alex Morrison, D P Thomas, Ji Li
Journal: Circulation (2011)

Background:  Aging is associated with a reduced tolerance to myocardial ischemia/reperfusion (I/R) injury. SIRT1, a putative anti-aging protein, is thought to be a potential interventional target for age-related ischemic heart disease due to its ability to attenuate the age-dependent decline in cardiac function. We hypothesized that SIRT1 is involved in the intolerance of the aged heart to ischemic stress.   Methods and Results:  4-6 months-old (young) and 24-26 months-old (aged) male C57BL/6 mice, 4-6 months-old male  Sirt1  +/-  heterozygous knockout and  Sirt1  +/+  wild type littermates mice were used. The results show that SIRT1 is predominantly localized in the nuclei of cardiomyocytes, and SIRT1 protein levels in the aged hearts are significantly lower than those in young hearts; a similar discrepancy was also found between  Sirt1  +/-  and  Sirt1  +/+  hearts (n=4-6,  p  p  p  in vivo . Moreover, after 20 min of LAD coronary ligation followed by 4 hrs of reperfusion, myocardial infarction size in aged and  Sirt1  +/-  hearts is markedly higher than in young and  Sirt1  +/+  hearts (45% and 31%, respectively, all  p  Sirt1  +/-  hearts to 8% and 7%, respectively (all  p  p  vs.  vehicle).   Conclusions:  Increased susceptibility of the aged heart to I/R injury is largely attributed to impaired cardiac SIRT1 activity, and pharmacological SIRT1 activation can restore tolernace of aged heart to ischemic insults. Therefore, modulating SIRT1 activity may be a beneficial therapeutic strategy for the elderly with acute coronary syndromes.
Abstract 14049: Jmjd8 is an Important Regulator of Angiogenic Sprouting
Authors: Jes-Niels Boeckel, David Kaluza, Anuradha Doddaballapur, Jens Kroll, Stefanie Dimmeler
Journal: Circulation (2012)

Proteins containing a Jumonji C (JmjC) domain have important cellular functions by either hydroxylating or demethylating proteins. Jmjd6 and the important hypoxia-related protein FIH1 belong to the...
Calcium supplementation during pregnancy reduces risk of high blood pressure, pre-eclampsia and premature birth compared with placebo?
Authors: 韩肖燕, Sibai Baha M
Journal: BMJ (2011)

背景许多的随机实验都致力于研究孕期饮食补钙对于妊娠期高血压以及相关疾病的治疗效果。这些实验的结果是矛盾的，至今还无定论。这些研究在研究对象（妊娠期高血压和先兆子痫患者的比例），孕周（13～32周不等），样本量（22～4161例）以及研究结果的判定方面都不同。
Improving national surveillance of Lyme neuroborreliosis in Denmark through electronic reporting of specific antibody index testing from 2010 to 2012
Authors: R B Dessau, L Espenhain, K Mølbak, T G Krause, M Voldstedlund
Journal: Eurosurveillance (2015)

Our aim was to evaluate the results of automated surveillance of Lyme neuroborreliosis (LNB) in Denmark using the national microbiology database (MiBa), and to describe the epidemiology of laboratory-confirmed LNB at a national level. MiBa-based surveillance includes electronic transfer of laboratory results, in contrast to the statutory surveillance based on manually processed notifications. Antibody index (AI) testing is the recommend laboratory test to support the diagnosis of LNB in Denmark. In the period from 2010 to 2012, 217 clinical cases of LNB were notified to the statutory surveillance system, while 533 cases were reported AI positive by the MiBa system. Thirty-five unconfirmed cases (29 AI-negative and 6 not tested) were notified, but not captured by MiBa. Using MiBa, the number of reported cases was increased almost 2.5 times. Furthermore, the reporting was timelier (median lag time: 6 vs 58 days). Average annual incidence of AI-confirmed LNB in Denmark was 3.2/100,000 population and incidences stratified by municipality ranged from none to above 10/100,000. This is the first study reporting nationwide incidence of LNB using objective laboratory criteria. Laboratory-based surveillance with electronic data-transfer was more accurate, complete and timely compared to the surveillance based on manually processed notifications. We propose using AI test results for LNB surveillance instead of clinical reporting.