Experimental Study of Acquired Resistance of the Rabbit's Renal Epithelium to Mercuric Chloride
Authors: Warren C. Hunter
Journal: Annals of Internal Medicine (1929)

Article1 February 1929Experimental Study of Acquired Resistance of the Rabbit's Renal Epithelium to Mercuric ChlorideWARREN C. HUNTER, M.A., M.D.WARREN C. HUNTER, M.A., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-8-796 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous paper I (1) have shown that a high degree of resistance to the injurious effects of uranium in the kidney can be experimentally produced. In a considerable number of rabbits it was found that 54 to 96 times the quantity of poison known to kill original renal tubular cells was insufficient to damage the regenerated epithelium in the same location. After administration of even the largest doses of uranium the metal was still excreted by the kidney and this together with the lack of histologic evidence of cell injury was considered to be proof of an acquired...References(1) HUNTER WC: Experimental Study of Acquired Resistance of the Rabbit's Renal Epithelium to Uranyl Nitrate. Ann. Int. Med., (April) 1928, i:747-789. Google Scholar(2) GIL Y GIL C: Die Immunität im Nierenepithelgewebe. Beitr. z. path. Anat., 1924, lxxii: 621. Google Scholar(3) SUZUKI T: Zur Morphologie der Nierensekretion unter physiologischen und pathologischen Bedingungen. Fischer, Jena, 1912. CrossrefGoogle Scholar(4) BARBOUR HG: Mercuric Chloride Poisoning in Animals Treated Unsuccessfully by Parænteral Administration of Hall's New Antidote. J. A. M. A., 1915, lxiv: 736. CrossrefGoogle Scholar(5) NAKATA T: Die Stadien der Sublimatniere des Menschen, nach ihren makroskopischen und mikroskopischen Besonderheiten. Beitr. z. path. Anat., 1922, lxx: 282-310. Google Scholar(6) FORBUS WD: Pathologic changes in Voluntary Muscle. II. Experimental study of degeneration and regeneration of striated muscle with vital stains. Arch. Path. and Lab. Med., 1926, ii: 486. Google Scholar(7) MENTEN ML: Pathological Lesions Produced in the Kidney by Small Doses of Mercuric Chloride. J. Med. Research, 1922, xliii: 315. Google Scholar(8) LYON G: Inflammatory Changes in the Kidney; an Experimental Study of the Action of Some Toxins and Poisons Upon the Kidney and also Upon the Spleen. J. Path. and Bact., 1903, iii: 401-455 Google Scholar(9) HEINEKE A: Die Veränderungen der menschlichen Niere nach Sublimatvergiftung mit besonderer Berűcksichtigung der Regeneration des Epithels. Beitr. z. path. Anat., 1909, xlv: 197-244. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon*Fellow in Medicine, National Research Council.†From the Pathological Laboratory, University of Michigan, Ann Arbor. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProtective effect of molybdenum on the acute toxicity of mercuric chlorideThe effects of damage to the renal tubular cell population in growing ratsCase 51-1976Scanning and transmission electron microscopy of mercuric chloride-induced acute tubular necrosis in rat kidneyScanning and Transmission EM of Rat Kidney Following Low Dose Mercuric Chloride AdministrationEnhancement of hepatic detoxification enzyme activity by dietary mercuric acetateExperimentelle NierenkrankheitenExperimentelle NierenkrankheitenDie Absonderung des Harns unter verschiedenen Bedingungen, einschließlich ihrer nervösen Beeinflussung und der Pharmakologie und Toxikologie der Niere 1 February 1929Volume 2, Issue 8Page: 796-806KeywordsEpitheliumKidneysRabbitsResearch laboratoriesTubular cells ePublished: 1 December 2008 Issue Published: 1 February 1929 PDF downloadLoading ...