GONOCOCCAL ENDOCARDITIS TREATED WITH ARTIFICIAL FEVER (KETTERING HYPERTHERM)
Authors: Robert H. Williams
Journal: Annals of Internal Medicine (1937)

Article1 June 1937GONOCOCCAL ENDOCARDITIS TREATED WITH ARTIFICIAL FEVER (KETTERING HYPERTHERM)ROBERT H. WILLIAMS, M.D.ROBERT H. WILLIAMS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-12-1766 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been known for many years that the gonococcus is quite susceptible to heat.1, 2It remained for Carpenter, Boak, Mucci and Warren3to determine by careful thermal death time gradient studies that 99 per cent of the cultures of several strains of gonococci are killed in vitro by 4 to 5 hours exposure to a temperature of 105.8° F. With the Kettering hypertherm even higher temperatures over longer periods of time may be administered to patients with comparative safety. The excellent clinical results obtained with this form of treatment in various gonococcal infections strongly suggest that the thermal...Bibliography1. STEINSCHNEIDERSCHÄFFER : Zur Biologie der Gonokokken, Berl. klin. Wchnschr., 1895, xxxii, 984. Google Scholar2. KOCHCOHN JA: Gonokokkeninfectionen; in KOLLE, W., KRAUS, R., and UHLENHUTH, P.: Handbuch der pathogenen Mikroörganismen, 1928, iv, 705. Google Scholar3. CARPENTERBOAKMUCCIWARREN CMRALASL: Studies on the physiologic effects of fever temperatures, Jr. Lab. and Clin. Med., 1933, xviii, 981. Google Scholar4. THAYER WS: Cardiac complications of gonorrhea, Bull. Johns Hopkins Hosp., 1922, xxxiii, 361. Google Scholar5. STONE E: Gonorrheal endocarditis, Jr. Urol., 1934, xxxi, 869. CrossrefGoogle Scholar6. KIRKLAND HB: Gonococcus endocarditis: report of a case, Am. Heart Jr., 1932, vii, 360. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nashville, Tennessee*Received for publication February 4, 1937.From the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.†This apparatus was supplied to Vanderbilt University Hospital through the kindness of Mr. C. F. Kettering, director of the Division of Research, General Motors Corporation, and Dr. Walter M. Simpson, Miami Valley Hospital, Dayton, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTREATMENT OF FEVERInfectious disease, fever, and the immune responseEffect of Hyperthermia on Rabbit MacrophagesTHE FUNCTION OF FEVERTemperature and host defenseHyperthermia and human leukocyte functions: effects on response of lymphocytes to mitogen and antigen and bactericidal capacity of monocytes and neutrophilsFEVER AS A MECHANISM OF RESISTANCESubacute bacterial endocarditis of nonstreptococcic etiologyRecent Researches on Arthritis and Rheumatism in the United States 1 June 1937Volume 10, Issue 12Page: 1766-1774KeywordsEndocarditisFeversHospital medicineNeisseria gonorrhoeaeSafetySafety studiesTemperature ePublished: 1 December 2008 Issue Published: 1 June 1937 PDF downloadLoading ...