tbuckley/cabot-search huggingface dataset:
PET imaging of gliomas: Status quo and quo vadis?
Authors: Norbert Galldiks, Philipp Lohmann, Michel Friedrich, Jan-Michael Werner, Isabelle Stetter, Michael M Wollring, Garry Ceccon, Carina Stegmayr, Sandra Krause, Gereon R Fink, Ian Law, Karl-Josef Langen, Joerg-Christian Tonn
Journal: Neuro-Oncology (2024)

PET imaging, particularly using amino acid tracers, has become a valuable adjunct to anatomical MRI in the clinical management of patients with glioma. Collaborative international efforts have led to the development of clinical and technical guidelines for PET imaging in gliomas. The increasing readiness of statutory health insurance agencies, especially in European countries, to reimburse amino acid PET underscores its growing importance in clinical practice. Integrating artificial intelligence and radiomics in PET imaging of patients with glioma may significantly improve tumor detection, segmentation, and response assessment. Efforts are ongoing to facilitate the clinical translation of these techniques. Considerable progress in computer technology developments (eg quantum computers) may be helpful to accelerate these efforts. Next-generation PET scanners, such as long-axial field-of-view PET/CT scanners, have improved image quality and body coverage and therefore expanded the spectrum of indications for PET imaging in Neuro-Oncology (eg PET imaging of the whole spine). Encouraging results of clinical trials in patients with glioma have prompted the development of PET tracers directing therapeutically relevant targets (eg the mutant isocitrate dehydrogenase) for novel anticancer agents in gliomas to improve response assessment. In addition, the success of theranostics for the treatment of extracranial neoplasms such as neuroendocrine tumors and prostate cancer has currently prompted efforts to translate this approach to patients with glioma. These advancements highlight the evolving role of PET imaging in Neuro-Oncology, offering insights into tumor biology and treatment response, thereby informing personalized patient care. Nevertheless, these innovations warrant further validation in the near future.
Harnessing lipid metabolism modulation for improved immunotherapy outcomes in lung adenocarcinoma
Authors: Yang Chen, Yu Zhou, Ran Ren, Yu Chen, Juan Lei, Yongsheng Li
Journal: Journal for ImmunoTherapy of Cancer (2024)

Background While anti-programmed cell death protein-1 (PD-1) monotherapy has shown effectiveness in treating lung cancer, its response rate is limited to approximately 20%. Recent research suggests that abnormal lipid metabolism in patients with lung adenocarcinoma may hinder the efficacy of anti-PD-1 monotherapy. Methods Here, we delved into the patterns of lipid metabolism in patients with The Cancer Genome Atlas (TCGA)-lung adenocarcinoma (LUAD) and their correlation with the immune microenvironment’s cellular infiltration characteristics of the tumor. Furthermore, the lipid metabolism score (LMS) system was constructed, and based on the LMS system, we further performed screening for potential agents targeting lipid metabolism. The mechanism of MK1775 was further validated using RNA sequencing, co-culture technology, and in vivo experiments. Results We developed an LSM system and identified a potential sensitizing agent, MK1775, which targets lipid metabolism and enhances the effects of anti-PD-1 treatment. Our results demonstrate that MK1775 inhibits tumor progression by influencing lipid crosstalk between tumor cells and tumor-associated macrophages and CD8 + T cells, thereby increasing the effectiveness of anti-PD-1 treatment. Further, we found that MK1775 inhibited the phosphatidylinositol 3-kinase(PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway, which on one hand downregulated FASN-mediated synthesis of fatty acids (FAs) to inhibit fatty acid oxidation of tumor-associated macrophages, and on the other hand, promoted IRF-mediated secretion of CXCL10 and CXCL11 to facilitate the infiltration of CD8 + T cells. Conclusions These findings emphasize the important role of lipid metabolism in shaping the complex tumor microenvironment. By manipulating the intricate intricacies of lipid metabolism within the tumor microenvironment, we can uncover and develop promising strategies to sensitize immunotherapy, potentially revolutionizing cancer treatment approaches.
Endoscopic submucosal dissection of challenging rectosigmoid anastomotic lesion made feasible by a multipolar adaptive traction device combined with a line
Authors: Elena De Cristofaro, Jérôme Rivory, Louis-Jean Masgnaux, Jean Grimaldi, Fabien Pinard, Timothée Wallenhorst, Mathieu Pioche
Journal: Endoscopy (2024)

Endoscopic submucosal dissection (ESD) is widely accepted as a minimally invasive treatment for most superficial colorectal neoplasms, enabling a high rate of en bloc R0 resection [1]. However, ESD is difficult to perform in selected cases, such as in anastomotic lesions following colorectal surgery. In such instances, ESD presents technical challenges due to severe fibrosis, limited space, the presence of staples, deformities, and suture lines from previous surgeries, which increase the risk of complications and unsuccessful outcomes [2] [3].
Underwater cricopharyngeal peroral endoscopic myotomy
Authors: Pavithra Ramakrishnan, Nabeel Azeem
Journal: Endoscopy (2024)

Peroral endoscopic myotomy (POEM) is a well-established third-space endoscopic technique that can be technically challenging when used to treat a cricopharyngeal bar, even for experienced operators, due to the limited working space in the hypopharynx and upper esophageal sphincter [1] [2]. Here we propose the use of saline immersion to improve the technical success rate of the procedure.
Endoscopic ultrasound-guided gastroenterostomy to treat obstructive gastric twist after laparoscopic sleeve gastrectomy
Authors: Laurent Monino, Yannick Deswysen, Maximilien Thoma, Pierre H. Deprez, Tom Moreels
Journal: Endoscopy (2024)

Sleeve gastrectomy is the number one bariatric surgical intervention worldwide to treat morbid obesity. The rate of gastric stenosis after sleeve gastrectomy is around 2 to 4% [1] [2]. A gastric twist represents a functional gastric stenosis. Endoscopic management with pneumatic dilation or stent is proposed as first-line therapy [1] [2] [3]. In case of failure, a surgical conversion to Roux-en-Y gastric bypass (RYGB) is performed. Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) using an oroenteric catheter is a new approach to treat a benign gastric outlet obstruction (GOO) [4] [5]. We report the case of a patient with a gastric twist after laparoscopic sleeve gastrectomy successfully treated with EUS-GE after failure of repeat endoscopic dilatation.
Profuse diarrhea after percutaneous change of a computed tomography-guided gastrostomy: endoscopic closure of a colocutaneous fistula
Authors: Amani Al Khatib, Anaïs Bertrand, Henri Duboc, Olivier Bonsack, Benoit Coffin, Heithem Soliman
Journal: Endoscopy (2024)

A 71-year-old patient was admitted after the accidental dislodgement of a computed tomography (CT)-guided percutaneous gastrostomy, placed 1 year prior. The initial procedure was uneventful and facilitated rapid weight gain. A percutaneous MIC-KEY tube (Avanos, Alpharetta, Georgia, USA) was rapidly placed along the previous route. As soon as nutrition was restarted, "on and off" profuse diarrhea occurred, ceasing as the nutrition was stopped and resuming immediately upon resumption. Opacification of the MIC-KEY tube revealed a fistulous tract between the transverse colon and the skin ([Video 1]). Conservative treatment was decided, involving the endoscopic closure of the residual colocutaneous fistula, achieved by placing an Ovesco clip (Ovesco Endoscopy, Tübingen, Germany) during a colonoscopy [1].
Enhanced visualization of vessels in submucosa by amber red color imaging in colonic endoscopic submucosal dissection
Authors: Ryohei Maruoka, Mitsuru Esaki, Yosuke Minoda, Yoshihiro Otsuka, Kazuhiro Haraguchi, Haruei Ogino, Eikichi Ihara
Journal: Endoscopy (2024)

Intraoperative bleeding is a major complication of endoscopic submucosal dissection (ESD). Various devices and techniques have been developed to control intraoperative bleeding [1] [2] [3] [4]. Amber red color imaging is a recently developed observation modality that integrates brightness and color-enhancement technology used in linked color imaging, characterized by an increased proportion of long-wavelength relative linked color imaging, which targets the mucosa [5]. These amber red color imaging features improve the visibility of blood vessels and active bleeding points in the deep submucosa. Herein, we present a case of a colonic laterally spreading tumor that was treated with ESD using amber red color imaging ([Video 1]).
Endotherapy for small-bowel recurrent bleeding from a jejunal cavernous hemangioma in an elderly patient
Authors: Noemi Gualandi, Pablo Cortegoso Valdivia, Giuliano Francesco Bonura, Paola Soriani, Mauro Manno
Journal: Endoscopy (2024)

An 83-year-old man, with a history of hypertension, diabetes, and chronic liver disease, presented to the emergency room with fatigue and melena. Blood tests revealed iron-deficiency anemia (Hb 6.5 g/dL). Esophagogastroduodenoscopy (EGD) showed a Forrest III ulcer in the gastric antrum and a small, nonbleeding gastric angiodysplasia, which was treated with argon plasma coagulation. As colonoscopy was unremarkable, the patient was discharged after a few days.
Enhancing visibility and hemostasis during necrosectomy for walled-off necrosis: the “dual-gel method”
Authors: Kazuki Hama, Haruka Toyonaga, Tatsuya Ishii, Masayo Motoya, Toshifumi Kin, Tsuyoshi Hayashi, Akio Katanuma
Journal: Endoscopy (2024)

Endoscopic necrosectomy is an effective treatment for walled-off necrosis (WON); however, bleeding complications can be life threatening and require an immediate response [1]. Blood accumulation within the WON compartment makes identifying bleeding blood vessels difficult. Furthermore, the use of clips for hemostasis increases the risk of leaving long-term remains within the WON. Recently, a method for maintaining visibility during gastrointestinal bleeding involving the injection of a gel with an appropriate viscosity (Viscoclear; Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan) was reported [2] [3]. Additionally, the hemostatic effect of a self-assembling peptide gel (PuraStat; 3-D Matrix Europe SAS, Lyon, France) used during gastrointestinal endoscopic procedures has been reported [4] [5]. Purastat is an aqueous peptide solution that becomes neutral upon contact with blood and body fluids, and its peptide molecules form fibers in solution to form a peptide hydrogel. This hydrogel quickly coats the bleeding point and stops the bleeding. In this case, we successfully employed a novel "dual-gel method" that uses Viscoclear and PuraStat to achieve hemostasis during endoscopic necrosectomy.
Successful endoscopic biliary intervention for duodenal peridiverticular papilla using a novel traction device
Authors: Kyosuke Tanaka, Junya Tsuboi, Kento Naruse, Hiroki Yukimoto, Shunsuke Nojiri, Tomoyuki Nomura
Journal: Endoscopy (2024)

Periampullary diverticulum is defined as herniation of the mucosa or submucosa through a defect in the muscular layer around the papilla [1]. Achieving selective biliary cannulation for peridiverticular papilla is challenging [1], and several endoscopic devices and techniques have recently been developed [1] [2] [3] [4]. Herein, we present a case of successful endoscopic biliary intervention using a novel traction device for the peridiverticular papilla in a patient with choledocholithiasis.
A rare case of pancreatic glomangiomyoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration
Authors: Dafan Chen, Shan Wu, Xinjian Wan
Journal: Endoscopy (2024)

A 67-year-old woman presented with a 3-month history of upper abdominal pain. No positive result was found in tumor markers and antinuclear antibodies. Magnetic resonance imaging (MRI) detected a 15 × 11-mm mass with a T1W low signal and T2W high signal, which was enhanced in the arterial phase and weakened in the delayed phase. Endoscopic ultrasound (EUS) revealed a 14 × 12-mm hypoechoic lesion with a heterogeneous echo and a few stripe hyperechoic tissues. Ultrasound elastography imaging was primarily dominated by yellow-green tones interspersed with small areas of red and blue hues. Contrast-enhanced ultrasound showed heterogeneous enhancement in the arterial phase that receded quickly in the venous phase. The specimens were obtained by EUS-guided fine needle aspiration (FNA) with a 22G puncture needle of wet suction. Pathological examination revealed round tumor cells with SMA(+), Syn(–), Ki67 (3%+), CD34 (vascular+), consistent with the characteristics of a glomangiomyoma ([Fig. 1]).
Rectal pulse granuloma: a rare condition presenting as a subepithelial lesion
Authors: Cong Yuan, Xue-Mei Lin, Chun-Hui Xi, Dan Sun, Xiao-Bo Wang, Guo-Dong Yang, Xian-Fei Wang
Journal: Endoscopy (2024)

A pulse granuloma is a rare benign entity that typically occurs in the oral cavity [1]. Herein, we report a case of a subepithelial lesion (SEL) located in the distal rectum, which was diagnosed as a rectal pulse granuloma after its removal by endoscopic submucosal dissection (ESD).
Application of through-the-scope twin clip for defect closure after gastric gastrointestinal stromal tumor transoral super minimally invasive surgery resection
Authors: Chenyang Li, Shuling Li, Tao Wang, Yan Xu, Zhongrui Xu, Fuxiu Huang, Chao Chen
Journal: Endoscopy (2024)

The closure of large or perforated defects has posed a significant challenge in the evolution of endoscopic treatments. The over-the-scope (OTS) clip, once the mainstay for such closures, has certain limitations, such as the necessity for pre-procedure attachment to the endoscope's tip, which may entail additional surgical entries and potentially longer operative times, increasing the risk of complications like postoperative peritonitis [1].
Supragel-mediated efficient generation of pancreatic progenitor clusters and functional glucose-responsive islet-like clusters
Authors: Hongmeng Ma, Lilin Xu, Shengjie Wu, Songdi Wang, Jie Li, Sifan Ai, Zhuangzhuang Yang, Rigen Mo, Lei Lin, Yan Li, Shusen Wang, Jie Gao, Chen Li, Deling Kong
Journal: Bioactive Materials (2024)
Self-guided digital behavioural therapy versus active control for fibromyalgia (PROSPER-FM): a phase 3, multicentre, randomised controlled trial
Authors: R Michael Gendreau, Lance M McCracken, David A Williams, Juan V Luciano, Yifei Dai, Nicolette Vega, Zunera Ghalib, Kristen Guthrie, Allison C Kraus, Michael J Rosenbluth, Ben Vaughn, Jennifer M Zomnir, Dana Reddy, Andrea L Chadwick, Daniel J Clauw, Lesley M Arnold
Journal: The Lancet (2024)
Efficacy and safety of SGLT2 inhibitors with and without glucagon-like peptide 1 receptor agonists: a SMART-C collaborative meta-analysis of randomised controlled trials
Authors: Ellen M Apperloo, Brendon L Neuen, Robert A Fletcher, Niels Jongs, Stefan D Anker, Deepak L Bhatt, Javed Butler, David Z I Cherney, William G Herrington, Silvio E Inzucchi, Meg J Jardine, Chih-Chin Liu, Kenneth W Mahaffey, Darren K McGuire, John J V McMurray, Bruce Neal, Milton Packer, Vlado Perkovic, Marc S Sabatine, Scott D Solomon, Natalie Staplin, Michael Szarek, Muthiah Vaduganathan, Christoph Wanner, David C Wheeler, Stephen D Wiviott, Faiez Zannad, Hiddo J L Heerspink
Journal: The Lancet Diabetes & Endocrinology (2024)
Potential population-level effects of HIV self-test distribution among key populations in Côte d'Ivoire, Mali, and Senegal: a mathematical modelling analysis
Authors: Romain Silhol, Mathieu Maheu-Giroux, Nirali Soni, Arlette Simo Fotso, Nicolas Rouveau, Anthony Vautier, Clémence Doumenc-Aïdara, Olivier Geoffroy, Kouassi Noel N'Guessan, Younoussa Sidibé, Odé Kanku Kabemba, Papa Alioune Gueye, Pauline Dama Ndeye, Christinah Mukandavire, Peter Vickerman, Abdelaye Keita, Cheikh Tidiane Ndour, Joseph Larmarange, Marie-Claude Boily, Elvis Georges Amani, Kéba Badiane, Céline Bayac, Anne Bekelynck, Marie-Claude Boily, Sokhna Boye, Guillaume Breton, Marc d'Elbée, Alice Desclaux, Annabel Desgrées du Loû, Papa Moussa Diop, Eboi Ehui, Graham Medley, Kévin Jean, Abdelaye Keita, Arsène Kra Kouassi, Odette Ky-Zerbo, Joseph Larmarange, Mathieu Maheu-Giroux, Raoul Moh, Rosine Mosso, Cheikh Tidiane Ndour, David Paltiel, Dolorès Pourette, Nicolas Rouveau, Romain Silhol, Arlette Simo Fotso, Fern Terris-Prestholt, Métogara Mohamed Traoré, Clémence Doumenc-Aïdara, Olivier Geoffroy, Odé Kanku Kabemba, Anthony Vautier, Armand Abokon, Camille Anoma, Annie Diokouri, Blaise Kouamé, Venance Kouakou, Odette Koffi, Alain Kpolo, Josiane Tety, Yacouba Traore, Jules Bagendabanga, Djelika Berthé, Daouda Diakité, Mahamadou Diakité, Youssouf Diallo, Minta Daouda, Septime Hessou, Saidou Kanambaye, Abdul Karim Kanouté, Bintou Dembélé Keita, Dramane Koné, Mariam Koné, Almoustapha Maiga, Aminata Saran Keita, Fadiala Sidibé, Madani Tall, Adam Yattassaye Camara, Abdoulaye Sanogo, Idrissa Bâ, Papa Amadou Niang Diallo, Fatou Fall, NDèye Fatou NGom Guèye, Sidy Mokhtar Ndiaye, Alassane Moussa Niang, Oumar Samba, Safiatou Thiam, Nguissali M.E. Turpin, Seydou Bouaré, Cheick Sidi Camara, Brou Alexis Kouadio, Sophie Sarrassat, Souleyman Sow, Agnes Eponon Ehua, Amélé Kouvahe, Marie-Anne Montaufray, Pauline Dama Ndeye
Journal: The Lancet HIV (2024)

During 2019-21, the AutoTest VIH, Libre d'accéder à la connaissance de son Statut (ATLAS) programme distributed around 380 000 HIV self-testing kits to key populations, including female sex workers, men who have sex with men, and their partners, in Côte d'Ivoire, Mali, and Senegal. We aimed to estimate the effects of the ATLAS programme and national scale-up of HIV self-test distribution on HIV diagnosis, HIV treatment coverage, HIV incidence, and HIV-related mortality.
A deep learning-based model to estimate pulmonary function from chest x-rays: multi-institutional model development and validation study in Japan
Authors: Daiju Ueda, Toshimasa Matsumoto, Akira Yamamoto, Shannon L Walston, Yasuhito Mitsuyama, Hirotaka Takita, Kazuhisa Asai, Tetsuya Watanabe, Koji Abo, Tatsuo Kimura, Shinya Fukumoto, Toshio Watanabe, Tohru Takeshita, Yukio Miki
Journal: The Lancet Digital Health (2024)
Impact of different categories of intermediate risk factors on the recurrence of papillary thyroid carcinoma: a retrospective cohort study
Authors: Qiang Chen, Xiuhe Zou, Feng Liu, Anping Su, Yong Jiang, Tao Wei, Rixiang Gong, Jingqiang Zhu, Zhihui Li
Journal: International Journal of Surgery (2024)

Data regarding the long-term recurrence in patients with intermediate-risk papillary thyroid carcinoma (PTC) are limited. The aim of this study was to assess the impact of primary tumor-related risk factors and lymph node (LN)-only risk factors on recurrence-free survival (RFS) in patients with intermediate-risk PTC.
Perioperative intravenous lidocaine infusion improves postoperative analgesia after hysterectomy: A systematic review and meta-analysis of randomized controlled trials
Authors: Peng Tang, Qingxia Sun, Zhihao Li, Xiangyi Tong, Fengshou Chen
Journal: International Journal of Surgery (2024)

Background: The effectiveness of intravenous lidocaine in reducing acute pain after hysterectomy remains uncertain. We conducted a meta-analysis of randomized controlled trials (RCTs) to investigate the impact of intravenous lidocaine on post-hysterectomy recovery. Methods: This study was completed based on the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. A systematic search was conducted in PubMed/MEDLINE, the Cochrane Controlled Trials Register (CENTRAL), and Embase up to July 27, 2023. We identified randomized controlled trials (RCTs) involving hysterectomy patients comparing lidocaine to a placebo. Outcome measures included postoperative pain scores at rest and during movement, opioid consumption, postoperative nausea and vomiting (PONV), improvements in functional gastrointestinal recovery, and Quality of Recovery (QoR) scores. Results: Nine RCTs were included in the meta-analysis, comprising 352 patients who received intravenous lidocaine and 354 controls. The analysis revealed that intravenous lidocaine significantly reduced postoperative pain scores at rest at 2, 6, 8, and 24 hours following hysterectomy, as well as postoperative opioid consumption within 24 hours and PONV rates. Furthermore, no observed benefit was noted in shortening the time to first flatus with intravenous lidocaine administration post-hysterectomy. Conclusion: Intravenous lidocaine administration effectively reduces acute postoperative pain, opioid consumption, and PONV rates following hysterectomy. Lidocaine serves as an opioid-sparing agent, reducing the morphine equivalent dose while maintaining a similar degree of postoperative pain.
Prognostic model for resected borderline and locally advanced pancreatic cancer after neoadjuvant chemotherapy
Authors: Jimin Son, Woohyung Lee, Jung Bok Lee, Kwangpyo Hong, Min Kyu Sung, Yejong Park, Eunsung Jun, Ki Byung Song, Dae Wook Hwang, Jae Hoon Lee, Song Cheol Kim
Journal: International Journal of Surgery (2024)

The current AJCC 8th has been reported to have a poor ability to predict the prognosis in patients with resected borderline resectable pancreatic cancer and locally advanced pancreatic cancer following neoadjuvant chemotherapy. This study was aimed to develop an improved prognostic model by incorporating pathology and parameters of biologic response (BR).
Exploring potential plasma drug targets for cholelithiasis through multiancestry Mendelian randomization
Authors: Xiaoduo Liu, Lubo Shi, Shutian Zhang, Anni Zhou
Journal: International Journal of Surgery (2024)

Background: Cholelithiasis poses significant health and economic burdens, necessitating novel pharmacological targets to enhance treatment efficacy. Method: Based on genome-wide association analysis (GWAS) studies, we performed two-sample Mendelian randomization (MR) analysis based on plasma proteomics to explore potential drug targets in European (n Case =40,191 and n Control =361,641) and Asian (n Case =9,305 and n Control =168,253) populations. We confirmed the directionality and robust correlation of the drug targets with the results through reverse MR analysis, Steiger filtering, Bayesian colocalization, phenotype scanning and replication in multiple databases. Further exploration of the safety and possible mechanisms of action of phenome-wide MR analysis and protein‒protein interactions (PPIs) as individual drug targets was performed. Results: Our proteomics-based MR analyses suggested that FUT3 (OR=0.87; 95% CI, 0.84-0.89; P =4.70×10 −32 ), NOE1 (OR=0.58; 95% CI, 0.52-0.66; P =4.21×10 −23 ), UGT1A6 (OR=0.68; 95% CI, 0.64-0.73; P =9.58×10 −30 ) and FKBP52 (OR=1.75; 95% CI, 1.37-2.24; P =8.61×10 −6 ) were potential drug targets in Europeans, whereas KLB (OR=1.11; 95% CI, 1.07-1.16; P =7.59×10 −7 ) and FGFR4 (OR=0.94; 95% CI, 0.91-0.96; P =4.07×10 −6 ) were valid targets in East Asians. There was no reverse causality for these drug targets. Evidence from Bayesian colocalization analyses supported that exposure and outcome shared consistent genetic variables. Phenome-wide MR analysis suggested the potential deleterious effects of NOE1 and FGFR4. PPI analysis confirmed the pathways associated with the potential targets involved in bile acid metabolism. Conclusions: Genetically predicted levels of the plasma proteins FUT3, NOE1, UGT1A6 and FKBP52 have potential as prospective targets in Europeans. Moreover, the plasma levels of KLB and FGFR4 may serve as potential targets for the treatment of cholelithiasis in East Asians.
Hypertriglyceridemic acute pancreatitis: A bibliometric analysis from 2002 to 2023
Authors: Wei Yao, Zhiqin Xie, Ming Li, Mingchang Zhang, Wei Dai, Bingchen Duan, Min Wang, Caixi Tang, Zhaoming Yang
Journal: International Journal of Surgery (2024)

Yao, Wei; Xie, Zhiqin; Li, Ming; Zhang, Mingchang; Dai, Wei; Duan, Bingchen; Wang, Min; Tang, Caixi; Yang, Zhaoming Author Information