SULFANILAMIDE AND MENINGITIS
Authors: S. W. Sappington, Grant O. Favorite
Journal: Annals of Internal Medicine (1939)

Article1 October 1939SULFANILAMIDE AND MENINGITISS. W. SAPPINGTON, M.D., F.A.C.P., GRANT O. FAVORITE, M.D., F.A.C.P.S. W. SAPPINGTON, M.D., F.A.C.P.Search for more papers by this author, GRANT O. FAVORITE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-4-576 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe therapy of infections has developed almost exclusively along the lines of specificity, and an excellent example of this is the use of the many types of anti-serum for the treatment of pneumococcus pneumonia. Likewise in drug therapy, the real successes have been mostly specific in their application. Used at first as a specific in beta hemolytic streptococcus infections, the therapeutic trial of sulfanilamide and its derivatives has been extended clinically and experimentally to cover the most remarkable variety of infections. This list includes such dissimilar organisms as gram positive and negative micrococci, aerobic and anaerobic bacilli, acid fast bacilli,...References1. GAYCLARK FPAR: On the mode of action of sulfanilamide in experimental streptococcus empyema, Jr. Exper. Med., 1937, lxvi, 535. CrossrefGoogle Scholar2. BLISSLONG EAPH: Observations on the mode of action of sulfanilamide, Jr. Am. Med. Assoc., 1937, cix, 1524. CrossrefGoogle Scholar3. OSGOOD EE: Culture of human marrow. Studies on the mode of action of sulfanilamide, Jr. Am. Med. Assoc., 1938, cx, 349. CrossrefGoogle Scholar4. TRIPOLI CJ: Bacterial meningitis, Jr. Am. Med. Assoc., 1936, cvi, 171. CrossrefGoogle Scholar5. GRAY HJ: Streptococcic meningitis, Jr. Am. Med. Assoc., 1935, cv, 92. CrossrefGoogle Scholar6. LONGBLISS PHEA: The clinical uses of sulfanilamide and its derivatives in the treatment of infectious diseases, ANN. INT. MED., 1937, xi, 575. Google Scholar7. CANFIELD N: Streptococcus meningitis, report of a case with recovery, Jr. Michigan Med. Soc., 1933, xxxii, 108. Google Scholar8. ZELIGS M: Streptococcic meningitis, report of 2 cases with recovery, Am. Jr. Dis. Child., 1935, l, 1497. CrossrefGoogle Scholar9. SCHWENTKER FF: The use of para-amino-benzene-sulphonamide or its derivatives in the treatment of beta hemolytic streptococcal meningitis, Bull. Johns Hopkins Hosp., 1937, lx, 297. Google Scholar10. NEALAPPLEBAUM JBE: Experience with sulfanilamide in meningitis, Am. Jr. Med. Sci., 1938, cxcv, 175. CrossrefGoogle Scholar11. APPLEBAUM E: Personal communication. Google Scholar12. TRACHSLER WH: Streptococcic meningitis, with special emphasis on sulfanilamide therapy, Jr. Pediat., 1937, xi, 248. CrossrefGoogle Scholar13. CAREY BW: The use of para-amino-benzene-sulfonamide and its derivatives in the treatment of infections due to the beta Streptococcus hemolyticus, the meningococcus, and the gonococcus, Jr. Pediat., 1937, xi, 202. CrossrefGoogle Scholar14. NEALJACKSONAPPLEBAUM JBHWE: A comprehensive study of meningitis secondary to otitic or sinus infection, Ann. Otol., Rhin. and Laryngol., 1934, xliii, 658. CrossrefGoogle Scholar15. MELLONCOOPER RRFB: The biphasic nature of certain alpha-prime (?) hemolytic streptococci, Proc. Soc. Exper. Biol. and Med., 1938, xxxviii, 158. CrossrefGoogle Scholar16. MERTINSMERTINS PSPS: Meningitis due to the Type 4 pneumococcus, with recovery, Arch. Otolaryngol., 1937, xxv, 657. CrossrefGoogle Scholar17. CALDWELLBYRNE JRPS: Recovery from pneumococcal meningitis, Brit. Med. Jr., 1937, i, 1204. Google Scholar18. MITCHELLTRACHSLER AGWH: Report on the use of sulfanilamide and its derivatives at the Children's Hospital of Cincinnati, Jr. Pediat., 1937, xi, 183. CrossrefGoogle Scholar19. BASMANPERLEY JAM: Report of patients treated with sulfanilamide at the St. Louis Children's Hospital, Jr. Pediat., 1937, xi, 212. CrossrefGoogle Scholar20. FOTHERGILL LD: Hemophilus influenzae (Pfeiffer bacillus) meningitis and its specific treatment, New England Jr. Med., 1937, ccxvi, 587. CrossrefGoogle Scholar21. SILVERTHORNEFRASERSNELLING NDTCE: Influenzal meningitis, Jr. Pediat., 1937, x, 228. CrossrefGoogle Scholar22. SCHWENTKER FF: Quoted by Fothergill—personal communication. Google Scholar23. MCINTOSHWILCOXWRIGHT RDAFH: Results of sulfanilamide treatment at the Babies' Hospital, New York City, Jr. Pediat., 1937, xi, 167. CrossrefGoogle Scholar24. MCQUARRIE I: Report of cases treated with sulfanilamide (prontosil and prontylin), Jr. Pediat., 1937, xi, 187. Google Scholar25. HAGEMAN PO: Clinical experience in the use of sulfanilamide at the New Haven Hospital, Jr. Pediat., 1937, xi, 195. CrossrefGoogle Scholar26. RICHFOLLIS ARRH: The inhibitory effect of sulfanilamide on the development of experimental tuberculosis in the guinea pig, Bull. Johns Hopkins Hosp., 1938, lxii, 77. Google Scholar27. SCHWENTKERGELMANLONG FFSPH: The treatment of meningococcic meningitis with sulfanilamide, Jr. Am. Med. Assoc., 1937, cviii, 1407. CrossrefGoogle Scholar28. MCDONALDHENTHORNETHOMPSON JRJCL: Role of anaerobic streptococci in human infections, Arch. Path., 1937, xxiii, 230. Google Scholar29. SMITH FW: Anaerobic beta hemolytic streptococcus meningitis of otitic origin treated with sulfanilamide and culminating in complete recovery, Jr. Am. Med. Assoc., 1938, cx, 887. CrossrefGoogle Scholar30. United States Public Health Reports, December, 1934, 1935. Google Scholar31. LEVY GH: Meningococcus meningitis, report of 176 cases treated with Ferry's antitoxin, Jr. Pediat., 1937, xi, 868. Google Scholar32. HOYNE AL: Intravenous treatment of meningococcic meningitis with meningococcus antitoxin, Jr. Am. Med. Assoc., 1936, cvii, 478. CrossrefGoogle Scholar33. SCHWENTKER FF: Treatment of meningococcus meningitis with sulfanilamide, Jr. Pediat., 1937, xi, 874. Google Scholar34. BERNSTEIN SS: Report on the use of sulfanilamide at the Children's Hospital of Michigan, Jr. Pediat., 1937, xi, 199. Google Scholar35. CAREY BW: The use of para-aminobenzenesulfonamide and its derivatives in the treatment of infections due to the beta hemolytic streptococcus, the meningococcus and the gonococcus, Jr. Pediat., 1937, xi, 202. CrossrefGoogle Scholar36. BRENNEMAN J: Report on sulfanilamide from the Children's Memorial Hospital of Chicago, Jr. Pediat., 1937, xi, 239. Google Scholar37. WILLIEN LJ: Sulfanilamide therapy in meningococcic meningitis, Jr. Am. Med. Assoc., 1938, cx, 630. CrossrefGoogle Scholar38. BROWN TM: Protective action of sulfanilamide and antimeningococcus serum on meningococcus infection of mice, Bull. Johns Hopkins Hosp., 1937, lxi, 272. Google Scholar39. BRANHAMROSENTHAL SESM: Studies in chemotherapy. Sulfanilamide, serum and combined drug and serum therapy in experimental meningococcus and pneumococcus infections in mice, Pub. Health Rept., 1937, lii, 685. CrossrefGoogle Scholar40. NETER E: Bacteriostatic action of sulfanilamide upon meningococcus in spinal fluid, Proc. Soc. Exper. Biol. and Med., 1938, xxxviii, 37. CrossrefGoogle Scholar41. MARVINWILKINSON HPWE: Gonococcic meningitis, results of treatment with sulfanilamide, Jr. Am. Med. Assoc., 1938, cx, 800. CrossrefGoogle Scholar42. COLEBROOKBUTTLEO'MEARA LGARA: The mode of action of para-aminobenzenesulphonamide and prontosil in hemolytic streptococcal infections, Lancet, 1936, ii, 1323. CrossrefGoogle Scholar43. LOCKWOOD JS: Personal Communication. Google Scholar44. HOARE ED: Bactericidal changes induced in human blood and serum by sulphamidochryspodine and sulphanilamide, Lancet, 1938, i, 655. CrossrefGoogle Scholar45. HOYNE AL: Meningococcus meningitis, Jr. Pediat., 1937, xi, 863. Google Scholar46. TOOMEYKIMBALL JAER: Meningitis caused by Streptococcus haemolyticus and treated with sulfanilamide, Jr. Am. Med. Assoc., 1939, cxii, 2586. CrossrefGoogle Scholar47. LONGBLISS PHEA: The clinical and experimental use of sulfanilamide, sulfapyridine and allied compounds, 1939, The Macmillan Company, New York. Google Scholar48. ALLANMAYERWILLIAMS WBSR: Pneumococcus meningitis with recovery; report of 3 cases, Am. Jr. Med. Sci., 1938, cxcvi, 99. CrossrefGoogle Scholar49. FINLANDBROWNRAUH MJWAE: Treatment of pneumococcic meningitis; study of 10 cases treated with sulfanilamide alone or in various combinations with specific antipneumococcic serum and complement, including 6 recoveries, New England Jr. Med., 1938, ccxviii, 1033. CrossrefGoogle Scholar50. MACKEITHOPPENHEIMER RCG: Pneumococcal meningitis. Report on five consecutive cases treated with sulphanilamide-pyridine (M. & B. 693), Lancet, 1939, i, 1099. CrossrefGoogle Scholar51. HEWELLMITCHELL BAAG: Treatment of pneumococcic meningitis with sulfanilamide; review of literature and report of 6 additional cases, Jr. Am. Med. Assoc., 1939, cxii, 1033. Google Scholar52. BRANHAMMITCHELLBRAININ SERHW: Gonococcic meningitis, Jr. Am. Med. Assoc., 1938, cx, 1804. CrossrefGoogle Scholar53. FOLSOMGERCHOW TGKE: Influenzal meningitis successfully treated with sulfanilamide, West Virginia Med. Jr., 1938, xxxiv, 254. Google Scholar54. BANKS HS: Serum and sulphanilamide in acute meningococcal meningitis; preliminary survey based on 113 cases, Lancet, 1938, ii, 7. CrossrefGoogle Scholar55. WAGHELSTEIN JM: Sulfanilamide in treatment of 106 patients with meningococcic infections, Jr. Am. Med. Assoc., 1938, cxi, 2172. CrossrefGoogle Scholar56. MURAZCHIRLEQUEGUINER GHA: Essais comparés de traitements (sérum; corps azoïque; sulfanilamide) de la méningite cérébro-spinale dans des régions coloniales rurales (Niger français), Presse méd., 1938, xlvi, 1113. Google Scholar57. SOMERS RB: M. & B. 693 in cerebrospinal fever. A review of 143 cases treated under field conditions, Lancet, 1939, i, 921. CrossrefGoogle Scholar58. BRYANTFAIRMAN JHD: Chemotherapy of cerebrospinal fever in the field, Lancet, 1939, i, 923. CrossrefGoogle Scholar59. LONGBLISSFEINSTONE PHEAWH: Mode of action, clinical use and toxic manifestations of sulfanilamide; further observations, Jr. Am. Med. Assoc., 1939, cxii, 115. CrossrefGoogle Scholar60. MCINTOSHWHITBY JLE: Mode of action of drugs of sulphonamide group, Lancet, 1939, i, 431. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication June 25, 1938.From the Department of Pathology, Hahnemann Medical College and Hospital, Philadelphia.We wish to thank the Staffs of Hahnemann, St. Luke's and West Jersey Hospital for permitting us to treat these cases.The sulfanilamide used was kindly furnished by the Abbott Laboratories and the Winthrop Chemical Co. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byType 19 Pneumococcal Meningitis: A Patient With 75-Year Clinical and Serologic Follow Up, With a Review of the Evolution of Therapy From Antiserum to Sulfonamides to PenicillinModern Medicine and the Twentieth Century Decline in Mortality: Evidence on the Impact of Sulfa DrugsScientific Evidence versus Therapeutic Demand: The Introduction of the Sulfonamides RevisitedBarron H. Lerner, MDSTREPTOCOCCIC VIRIDANS MENINGITIS: A REVIEW OF THE LITERATURE AND REPORT OF NINE RECOVERIES*ARCHIBALD L. HOYNE, M.D., F.A.C.P., HERBERT HERZON, M.D.Treatment of influenzal meningitis with anti-influenzalrabbit serum and sulfapyridineAdvances in treatment of meningitisInfluenzal meningitis 1 October 1939Volume 13, Issue 4Page: 576-597KeywordsDrug therapyMeningitisPneumococcusPneumoniaSpecificityStreptococcal infectionsStreptococcus ePublished: 1 December 2008 Issue Published: 1 October 1939 PDF downloadLoading ...