tbuckley/cabot-search huggingface dataset:
Bispecific killer engager for targeted depletion of PD-1 positive lymphocytes: A new avenue for autoimmune disease treatment
Authors: Lauren C Naatz, Shuyun Dong, Brian Evavold, Xiangyang Ye, Mingnan Chen
Journal: Acta Pharmaceutica Sinica B (2024)

Bispecific killer cell engagers (BiKEs) are a powerful tool to incite the killing power of natural killer (NK) cells. Here, we posited that the BiKE technology could be utilized to deplete activated immune cells expressing programmed death-1 (PD-1+ cells), and hence treat autoimmune diseases since these cells drive the disorders. We designed and generated PD-1 BiKE that targets an activating NK cell receptor, CD16, and PD-1. PD-1 BiKE showed specific binding to PD-1+ cells and engaged CD16 simultaneously. PD-1 BiKE enhanced NK cell-mediated apoptosis and depletion of PD-1+ Raji cells, but not PD-1- Raji cells. Further, PD-1 BiKE induced apoptosis of primary PD-1+ T lymphocytes that are highly relevant to autoimmune disease progression. The BiKE depleted 42% of primary T cells that were stimulated in vitro. Importantly, those ablated primary T cells were activated cells. Meanwhile, naive T cells were spared by the BiKE treatment, supporting the crucial selectivity of PD-1 BiKE-directed cell depletion. Lastly, PD-1 BiKE is more effective than a conventional depleting antibody in the depletion of PD-1+ cells. The current work supports PD-1 BiKE is a selective, potent, and safe tool to deplete PD-1+ cells.
Contemporary Management of Acute Ischemic Stroke
Authors: James P. Ho, William J. Powers
Journal: Annual Review of Medicine (2024)

In the past decade, adding mechanical thrombectomy (MT) of intracranial arterial occlusions to intravenous (IV) thrombolysis has revolutionized the treatment of acute ischemic stroke (AIS) by expanding the therapeutic window to 24 h. Treatment decisions require establishing a high probability of AIS; confirming time since last known well (LKW); assessing severity of the neurological deficit; determining any contraindications to IV thrombolysis; and performing neuroimaging, usually noncontrast computed tomography (NCCT), to exclude intracerebral hemorrhage. If time since LKW is less than 4.5 h, patients with disabling stroke without contraindications can proceed immediately to IV thrombolysis while the decision about MT is under way. For some patients, the MT decision can be made on the basis of clinical assessment, NCCT, and CT angiography showing a large vessel occlusion. Others may require additional neuroimaging. Patients who are not candidates for IV thrombolysis within 4.5 h or MT should be immediately evaluated for eligibility for extended-window IV thrombolysis or early antiplatelet treatment.
Efficacy of app-based mobile health interventions for stress management: A systematic review and meta-analysis of self-reported, physiological, and neuroendocrine stress-related outcomes
Authors: Vasile Sîrbu, Oana Alexandra David
Journal: Clinical Psychology Review (2024)

Stress is a significant mental health concern for the general population, highlighting the need for effective and scalable solutions, such as mobile health (mHealth) app interventions. This systematic review and meta-analysis aimed to investigate the effects of mHealth apps designed primarily to reduce stress and distress in non-clinical and subclinical populations. A comprehensive literature search was conducted up to August 2024, including studies that measured both self-reported and physiological stress outcomes. 80 studies were analyzed. A small but significant effect size (g = 0.33) was found for self-reported stress outcomes, with studies that used specific active controls, operated in naturalistic contexts, and had a low risk of bias showing significantly lower effect sizes. A similarly small effect size was observed for physiological outcomes (g = 0.24). Notably, studies that employed muscle and breathing relaxation, meditation strategies, personalized guidance, experimental usage settings, and measured acute stress responses demonstrated significantly higher effect sizes. Further analysis of specific physiological systems revealed small effect sizes for autonomic (g = 0.32) and cardiac outcomes (g = 0.36). The significant effects observed across both psychological and physiological outcomes support the efficacy and potential of mHealth apps for the self-management of stress responses in the broader population.
Baseline Epitope-Specific IgE Profiles are Predictive of Sustained Unresponsiveness or High Threshold One-Year Post OIT in the POISED Trial
Authors: Maria Suprun, Ashley Sang Eun Lee, Robert Getts, Simon Peck, Sayantani B. Sindher, Kari C. Nadeau, R. Sharon Chinthrajah, Stephen J. Galli, Hugh A. Sampson
Journal: Journal of Allergy and Clinical Immunology (2024)
Nanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion
Authors: Takuya Furuichi, Hiromasa Hirai, Takayuki Kitahara, Masayuki Bun, Masato Ikuta, Yuichiro Ukon, Masayuki Furuya, Richard O C Oreffo, Agnieszka A Janeczek, Jonathan I Dawson, Seiji Okada, Takashi Kaito
Journal: Bioactive Materials (2024)
Author’s Response to: Comment on “Impact of EML4-ALK Variants and Co-Occurring TP53 Mutations on Duration of First-Line ALK Tyrosine Kinase Inhibitor Treatment and Overall Survival in ALK Fusion-Positive NSCLC: Real-World Outcomes From the GuardantINFORM Database” and “Critical Evaluation of Methodological Approaches in ALK TKI Research: Addressing Confounding Factors and Statistical Robustness”
Authors: Kaushal Parikh
Journal: Journal of Thoracic Oncology (2024)
Lung Cancer in Romania
Authors: Gheorghe-Emilian Olteanu, Alon Vigdorovits, Robert Alexandru Barna, Laura Mazilu, Veronica Manolache, Vladimir Preoteasa, Sebastian Curcean, Andrei Roman, Natalia Motas, Mircea Dediu, Diana N Ionescu
Journal: Journal of Thoracic Oncology (2024)
Comment on “Impact of EML4-ALK Variants and Co-Occurring TP53 Mutations on Duration of First-Line ALK Tyrosine Kinase Inhibitor Treatment and Overall Survival in ALK Fusion-Positive NSCLC: Real-World Outcomes From the GuardantINFORM Database”
Authors: Jia Zhang, Guoying Wang, Xiaoming Zhou
Journal: Journal of Thoracic Oncology (2024)
Nucleotide coordinated polymers, a ROS-based immunomodulatory antimicrobial, doubly kill Pseudomonas aeruginosa biofilms of implant infections
Authors: Jinghuang Chen, Xianqing Tang, Qihan Sun, Xin Ji, Xingbo Wang, Zhendong Liu, Xu Zhang, Haijiao Xu, Fan Yang, Jian Sun, Xiurong Yang
Journal: Bioactive Materials (2024)
Risk of incident cancer in patients with Inflammatory Bowel Disease with prior breast cancer: a multicenter cohort study
Authors: Guillaume Le Cosquer, Julien Kirchgesner, Cyrielle Gilletta De Saint Joseph, Philippe Seksik, Aurélien Amiot, David Laharie, Maria Nachury, Cléa Rouillon, Vered Abitbol, Alexandre Nuzzo, Stéphane Nancey, Mathurin Fumery, Amélie Biron, Nicolas Richard, Romain Altwegg, Driffa Moussata, Benedicte Caron, Mathias Vidon, Catherine Reenaers, Mathieu Uzzan, Jean-Marie Reimund, Mélanie Serrero, Marion Simon, Alban Benezech, Félix Goutorbe, Anne-Laure Pelletier, Ludovic Caillo, Charlotte Vaysse, Florian Poullenot, Barbara Bournet, Samira Denguir, Frank Zerbib, Pauline Rivière, Charlotte Gagnière, Julie Assaraf, Guillaume Cadiot, Hedia Brixi, Guillaume Savoye, Clara Yzet, Franck Brazier, Laurent Peyrin-Biroulet, Mellie Heinemann, Nicolas Vigneron, Marie Coisnon, Justine Amaro, Mira Raad, Charlotte Mailhat
Journal: Clinical Gastroenterology and Hepatology (2024)

Breast cancer is the most common malignancy observed in patients with inflammatory bowel diseases (IBD). The aim of our study was to evaluate incident cancer rate (recurrence or new-onset cancer) in a cohort of patients with IBD with a history of breast cancer according to the subsequent IBD treatment provided.
Sedation practices in Gastrointestinal Endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) survey
Authors: Konstantinos Triantafyllou, Reena Sidhu, Tony Tham, Georgios Tziatzios, Claire Guy, Helmut Messmann, Marianna Arvanitakis, Cesare Hassan, Raf Bisschops, Ian Mark Gralnek
Journal: Endoscopy (2024)

AE: adverse event ECG: electrocardiogram EMR: endoscopic mucosal resection ESD: endoscopic submucosal dissection ESGE: European Society of Gastrointestinal Endoscopy ESGENA: European Society of Gastroenterology and Endoscopy Nurses and Associates EUS: endoscopic ultrasound ERCP: endoscopic retrograde cholangiopancreatography GI: gastrointestinal endoscopy MAC: monitored anesthesia care NAPS: nonanesthesiologist propofol sedation Q: question SaO2 : O2 saturation
Prognostic impact of donor mitochondrial genomic variants in myelodysplastic neoplasms after stem-cell transplantation
Authors: Jing Dong, Shahram Arsang-Jang, Tao Zhang, Zhongyuan Chen, Yung-Tsi Bolon, Stephen Spellman, Raul Urrutia, Paul Auer, Wael Saber
Journal: Journal of Hematology & Oncology (2024)

Mitochondrial DNA (mtDNA) variants in patients with myelodysplastic neoplasms (MDS) are shown to be prognostic of outcomes after allogeneic hematopoietic cell transplantation (allo-HCT). However, the prognostic impact of donor mtDNA variants is unknown. Here, we performed whole-genome sequencing on 494 donors who were matched to MDS patients enrolled in the Center for International Blood and Marrow Transplant Research (CIBMTR). We evaluated the impact of donor mtDNA variants on recipients' transplantation outcomes, including overall survival, relapse, relapse-free survival, and transplant-related mortality. The optimism-adjusted bootstrap method was employed to evaluate the prognostic performance of models that include donor mtDNA variants alone and combined with MDS- and HCT-related clinical factors. In the entire donor cohort, we identified 1,825 mtDNA variants, including 67 potential pathogenic variants. Genetic variants on MT-CYB and MT-ND5 genes were identified as independent predictors of posttransplant outcomes. Integration of donor mtDNA variants into the models based on the International Prognostic Scoring System-Revised (IPSS-R) could capture more prognostic information for MDS patients. Sensitivity analysis in 397 unrelated donors obtained similar results. More importantly, we found that incorporating donor mtDNA variants with donor age and the degree of HLA-matching could help to identify "suboptimal" younger HLA-well-matched unrelated donors and "optimal" older HLA-partially/mismatched unrelated donors. Our study shows that mtDNA variants in donors, including those from unrelated donors, hold prognostic value for MDS patients undergoing allo-HCT and augment the prognostic stratification of current scoring systems. These findings present an opportunity to refine donor selection strategies and improve posttransplant outcomes for MDS patients.
Female sex hormones inversely regulate acute kidney disease susceptibility throughout life
Authors: Yuichiro Kitai, Naoya Toriu, Takahisa Yoshikawa, Yoshiki Sahara, Sonoko Kinjo, Yoko Shimizu, Yuki Sato, Akiko Oguchi, Ryo Yamada, Makiko Kondo, Eiichiro Uchino, Keisuke Taniguchi, Hiroyuki Arai, Takayoshi Sasako, Hironori Haga, Shingo Fukuma, Naoto Kubota, Takashi Kadowaki, Minoru Takasato, Yasuhiro Murakawa, Motoko Yanagita
Journal: Kidney International (2024)

While epidemiological and experimental studies have demonstrated kidney-protective effects of estrogen and female sex in adulthood, some epidemiological data showed deterioration of kidney function during puberty when estrogen production increases. However, molecular mechanisms explaining these conflicting phenomena remain unknown. Here, we showed that the pubertal sex hormone surge in female mice increases susceptibility to kidney ischemia reperfusion injury partly via downregulation of insulin-like growth factor 1 receptor (IGF-1R) expression in proximal tubules. Adult mice ovariectomized pre-pubertally (at postnatal day 21) showed strong tolerance to kidney ischemia, which was partly reversed by the administration of 17β-estradiol, while adult mice ovariectomized post-pubertally (at 8 weeks of age) were vulnerable to kidney ischemia. Kidney tubular IGF-1R protein expression decreased during postnatal growth but was highly expressed in adult mice ovariectomized pre-pubertally and in infant mice, which might be partly explained by different expression of an E3 ligase (MDM2) of IGF-1R. Mice deficient of Igf-1r in proximal tubules (iIGF-1RKO mice) during postnatal kidney growth showed increased susceptibility to ischemic injury. RNA-seq and western blotting analysis using proximal tubular cells from pre-pubertally ovariectomized iIGF-1RKO and control mice revealed altered expression of cell cycle-associated molecules such as cyclin D1. These results suggest that Igf-1r deletion during postnatal growth renders proximal tubular cells susceptible to ischemia possibly via altered cell cycle regulation. Thus, our findings provide evidence that exposure to pubertal sex hormones leads to increased susceptibility to kidney ischemia, which is partly mediated by modulation of IGF-1R signaling.Graphical abstract
The 2024 China report of the Lancet Countdown on health and climate change: launching a new low-carbon, healthy journey
Authors: Wenjia Cai, Chi Zhang, Shihui Zhang, Yuqi Bai, Max Callaghan, Nan Chang, Bin Chen, Huiqi Chen, Liangliang Cheng, Hancheng Dai, Weicheng Fan, Dabo Guan, Yixin Hu, Yifan Hu, Junyi Hua, Cunrui Huang, Hong Huang, Jianbin Huang, Xiaomeng Huang, John S Ji, Qiaolei Jiang, Xiaopeng Jiang, Gregor Kiesewetter, Tiantian Li, Bo Li, Lu Liang, Borong Lin, Hualiang Lin, Huan Liu, Qiyong Liu, Zhao Liu, Zhu Liu, Yanxiang Liu, Shuhan Lou, Bo Lu, Chenxi Lu, Zhenyu Luo, Zhifu Mi, Yanqing Miao, Chao Ren, Marina Romanello, Jianxiang Shen, Jing Su, Rui Su, Yuze Sun, Xinlu Sun, Maria Walawender, Can Wang, Qing Wang, Qiong Wang, Laura Warnecke, Wangyu Wei, Xiaohui Wei, Sanmei Wen, Yang Xie, Hui Xiong, Bing Xu, Xiu Yang, Yuren Yang, Fanghong Yao, Le Yu, Wenhao Yu, Jiacan Yuan, Yiping Zeng, Jing Zhang, Rui Zhang, Shangchen Zhang, Shaohui Zhang, Mengzhen Zhao, Qi Zhao, Qiang Zhao, Dashan Zheng, Hao Zhou, Jingbo Zhou, Ziqiao Zhou, Yong Luo, Peng Gong
Journal: The Lancet Public Health (2024)
Women at the front line of the Marburg virus disease response in Rwanda: balancing clinical care, public health, and family life
Authors: Tsion Firew, Louise Mwiseneza, Malaika Asabwe, Ineza Nadine Vanessa, Marie Henriette Uwintwari, Françoise Nizeyimana, Doris Lorette Uwamahoro
Journal: The Lancet Global Health (2024)
Cost-effectiveness of a short-course antibiotic treatment strategy for the treatment of ventilator-associated pneumonia: an economic analysis of the REGARD-VAP trial
Authors: Yiying Cai, Suchart Booraphun, Andrew Yunkai Li, Gyan Kayastha, Paul Anantharajah Tambyah, Ben S Cooper, Nicholas Graves, Yin Mo
Journal: The Lancet Global Health (2024)
Leveraging cognitive neuroscience for making and breaking real-world habits
Authors: Eike K. Buabang, Kelly R. Donegan, Parnian Rafei, Claire M. Gillan
Journal: Trends in Cognitive Sciences (2024)

Habits are the behavioral output of two brain systems. A stimulus-response (S-R) system that encourages us to efficiently repeat well-practiced actions in familiar settings, and a goal-directed system concerned with flexibility, prospection, and planning. Getting the balance between these systems right is crucial: an imbalance may leave people vulnerable to action slips, impulsive behaviors, and even compulsive behaviors. In this review we examine how recent advances in our understanding of these competing brain mechanisms can be harnessed to increase the control over both making and breaking habits. We discuss applications in everyday life, as well as validated and emergent interventions for clinical populations affected by the balance between these systems. As research in this area accelerates, we anticipate a rapid influx of new insights into intentional behavioral change and clinical interventions, including new opportunities for personalization of these interventions based on the neurobiology, environmental context, and personal preferences of an individual.
Clinical Occupational Medicine.
Authors: Linda Rosenstock, Mark R. Cullen
Journal: Annals of Internal Medicine (1987)

Outstanding coverage of this field in a concise outline format that permits easy reference. Diseases are logically organized by system, with the approach to the patient thoroughly descibed for each--from history-taking to evaluation to disease classification and treatment. An invaluable section on workplace hazards superbly reviews each identifiable hazard or group of hazards. Includes information on product description and work associated with its use, clinical effects, evaluation, treatment and prevention.
Comment on ‘Failure of scabies treatment: a systemic review and meta-analysis’
Authors: Craig G Burkhart
Journal: British Journal of Dermatology (2024)

I offer three comments that were not discussed in a recent scabies article: (i) The mite has innate abilities to navigate to humans if within 4 inches of a potential host. (ii) Airborne transmission aids in their transmission and PPE clothing would reduce infestation. (iii) Ivermectin for 3 days would simplify and decrease duration of preventive measures of the spread of contagion and reinfestation.
The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap
Authors: Anneliene H. Jonker, Elena-Alexandra Tataru, Holm Graessner, David Dimmock, Adam Jaffe, Gareth Baynam, James Davies, Shruti Mitkus, Oxana Iliach, Rich Horgan, Erika F. Augustine, Alison Bateman-House, Anna Maria Gerdina Pasmooij, Tim Yu, Matthis Synofzik, Julie Douville, Larissa Lapteva, Philip John Brooks, Daniel O’Connor, Annemieke Aartsma-Rus
Journal: Nature Reviews Drug Discovery (2024)
Anticoagulation for Patients with Atrial Fibrillation Receiving Dialysis
Authors: Ziv Harel, Brendan Smyth, Sunil V. Badve, Daniel Blum, William Beaubien-Souligny, Samuel A. Silver, Edward Clark, Rita Suri, Thomas A. Mavrakanas, Joanna Sasal, Bhanu Prasad, John Eikelboom, Karthik Tennankore, Claudio Rigatto, Ivana Prce, Francois Madore, Fabrice Mac-Way, Andrew Steele, Yangmin Zeng, Michelle Sholzberg, Paul Dorian, Andrew T. Yan, Manish M. Sood, David J. Gladstone, Eric Tseng, Abhijat Kitchlu, Michael Walsh, Danny Sapir, Matthew J. Oliver, Murali Krishnan, Mercedeh Kiaii, Nikki Wong, Sradha Kotwal, Marissa Batisstella, Rey Acedillo, Charmaine Lok, Matthew Weir, Ron Wald
Journal: Journal of the American Society of Nephrology (2024)

Background: Atrial fibrillation is common in individuals receiving dialysis. The role of oral anticoagulation in this population is uncertain given its exclusion from previous seminal clinical trials. Our objective was to determine the feasibility of performing a large definitive trial to establish the optimal anticoagulation strategy in individuals with atrial fibrillation receiving dialysis. Methods: The SAFE-D trial was a parallel-group, open-label, allocation-concealed, pilot randomized control trial that took place at 28 centres in Canada and Australia. The trial included adults (≥18 y) undergoing dialysis with a history of non-valvular atrial fibrillation who met the CHADS-65 criteria. Participants were randomized 1:1:1 to receive dose-adjusted warfarin, apixaban 5 mg twice daily, or no oral anticoagulation and followed for 26 weeks. The primary outcomes evaluated the following measures of feasibility: a) recruitment of the target population within 2 years from the start of the trial; and b) adherence of &gt;80% of randomized patients to the allocated treatment strategy at the conclusion of follow-up. Secondary outcomes included stroke and bleeding. Results: From December 2019 through June 2022, 151 patients were enrolled and randomized to apixaban (n =51), warfarin (n=52) or no oral anticoagulation (n=48). Allowing for pauses related to the COVID pandemic, recruitment was completed in 30 months, and 123 (83%) of participants completed follow-up in their allocated treatment arm. There was one adjudicated stroke event. Eight participants had a major bleeding event (4 warfarin, 2 apixaban, 2 no oral anticoagulation). Death occurred in 15 participants (9 warfarin, 2 apixaban, 4 no oral anticoagulation). Time in the therapeutic range for warfarin recipients was 58% (IQR 47%-70%). Conclusions: We have demonstrated the feasibility of recruitment and adherence in a trial that compared different anticoagulation strategies in patients with atrial fibrillation receiving dialysis.
Association and causal mediation between marital status and depression in seven countries
Authors: Xiaobing Zhai, Henry H. Y. Tong, Chi Kin Lam, Abao Xing, Yuyang Sha, Gang Luo, Weiyu Meng, Junfeng Li, Miao Zhou, Yangxi Huang, Ling Shing Wong, Cuicui Wang, Kefeng Li
Journal: Nature Human Behaviour (2024)
Infographic. Multiligament knee injury (MLKI): an expert consensus statement on nomenclature, diagnosis, treatment and rehabilitation
Authors: Iain Robert Murray, Navnit S Makaram, Chryssa Neo, Andrew G Geeslin, Jorge Chahla, Gilbert Moatshe, Kay Crossley, Michelle E Kew, Aileen Davis, Maria Tuca, Hollis Potter, Dina C Janse van Rensburg, Carolyn A Emery, SeungPyo Eun, Hege Grindem, Frank R Noyes, Robert G Marx, Chris Harner, Bruce A Levy, Enda King, James L Cook, Daniel B Whelan, George F Hatch, Christopher J Wahl, Kristian Thorborg, James J Irrgang, Nicolas Pujol, Michael J Medvecky, Michael J Stuart, Aaron J Krych, Lars Engebretsen, James P Stannard, Peter MacDonald, Romain Seil, Gregory C Fanelli, Travis G Maak, K Donald Shelbourne, Evert Verhagen, Volker Musahl, Michael T Hirschmann, Mark D Miller, Robert C Schenck, Robert F LaPrade
Journal: British Journal of Sports Medicine (2024)
Associations of pulmonary microvascular blood volume with per cent emphysema and CT emphysema subtypes in the community: the MESA Lung study
Authors: Emilia A Hermann, Amin Motahari, Eric A Hoffman, Yifei Sun, Norrina Allen, Elsa D Angelini, Alain G Bertoni, David A Bluemke, Sarah E Gerard, Junfeng Guo, David W Kaczka, Andrew Laine, Erin Michos, Prashant Nagpal, James S Pankow, Coralynn S Sack, Benjamin Smith, Karen Hinckley Stukovsky, Karol E Watson, Artur Wysoczanski, R Graham Barr
Journal: Thorax (2024)

Background Pulmonary microvasculature alterations are implicated in emphysema pathogenesis, but the association between pulmonary microvascular blood volume (PMBV) and emphysema has not been directly assessed at scale, and prior studies have used non-specific measures of emphysema. Methods The Multi-Ethnic Study of Atherosclerosis Lung Study invited participants recruited from the community without renal impairment to undergo contrast-enhanced dual-energy CT. Pulmonary blood volume was calculated by material decomposition; PMBV was defined as blood volume in the peripheral 2 cm of the lung. Non-contrast CT was acquired to assess per cent emphysema and novel CT emphysema subtypes, which include the diffuse emphysema subtype and small-airways-related combined bronchitic-apical emphysema subtype. Generalised linear regression models included age, sex, race/ethnicity, body size, smoking, total lung volume and small airway count. Results Among 495 participants, 53% were never-smokers and the race/ethnic distribution was 35% white, 31% black, 15% Hispanic and 18% Asian. Mean PMBV was 352±120 mL; mean per cent emphysema was 4.95±4.75%. Lower PMBV was associated with greater per cent emphysema (−0.90% per 100 mL PMBV, 95% CI: −1.29 to –0.51). The association was of larger magnitude in participants with 10 or more pack-years smoking and airflow obstruction, but present among participants with no smoking history or airflow limitation, and was specific to the diffuse CT emphysema subtype (−1.48% per 100 mL PMBV, 95% CI: −2.31 to –0.55). Conclusion In this community-based study, lower PMBV was associated with greater per cent emphysema, including in participants without a smoking history or airflow limitation, and was specific to the diffuse CT emphysema subtype.