tbuckley/cabot-search huggingface dataset:
Silver Mineralized Protein Hydrogel with Intrinsic Cell Proliferation Promotion and Broad‐Spectrum Antimicrobial Properties for Accelerated Infected Wound Healing
Authors: Weiqiang Wang, Fengjiao Chu, Weifeng Zhang, Tingting Xiao, Jingjing Teng, Yan Wang, Bo He, Binghui Ge, Jiajia Gao, Honghua Ge
Journal: Advanced Healthcare Materials (2024)

The presence of multidrug-resistant bacteria has challenged the clinical treatment of bacterial infection. There is a real need for the development of novel biocompatible materials with broad-spectrum antimicrobial activities. Antimicrobial hydrogels show great potential in infected wound healing but are still being challenged. Herein, broad-spectrum antibacterial and mechanically tunable amyloid-based hydrogels based on self-assembly and local mineralization of silver nanoparticles are reported. The mineralized hydrogels are biocompatible and have the advantages of sustained release of silver, prolonged antimicrobial effect, and improved adhesion capacity. Moreover, the mineralized hydrogels display a significant antimicrobial effect against both Gram-positive and Gram-negative bacteria in cells and mice by inducing membrane damage and reactive oxygen species toxicity in bacteria. In addition, the mineralized hydrogels can rapidly accelerate wound healing by the synergy between their antibacterial activity and intrinsic improvement for cell proliferation and migration. This study provides a modular approach to developing a multifunctional protein hydrogel platform based on biomolecule-coordinated self-assembly for a wide range of biomedical applications.
Internal mammary regional management after neoadjuvant therapy in breast cancer
Authors: Zhao Bi, Chun-Hui Zheng, Tong-Yue Ren, Yong-Sheng Wang
Journal: International Journal of Surgery (2024)

Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, People's Republic of China, 250000 Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji Yan Road 440, Jinan, Shandong Province, People's Republic of China, Phone number: +86-0531-67626211. E-mail address: [email protected] (Y-S.Wang). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Blood and guts: how the intestinal microbiome shapes hematopoiesis and treatment of hematologic disease
Authors: Josaura Fernandez Sanchez, Arushana A. Maknojia, Katherine Y. King
Journal: Blood (2024)

Abstract Over the past 10 years, there has been a marked increase in recognition of the interplay between the intestinal microbiome and the hematopoietic system. Despite their apparent distance in the body, a large literature now supports the relevance of the normal intestinal microbiota to steady-state blood production, affecting both hematopoietic stem and progenitor cells as well as differentiated immune cells. Microbial metabolites enter the circulation where they can trigger cytokine signaling that influences hematopoiesis. Furthermore, the state of the microbiome is now recognized to affect outcomes from hematopoietic stem cell transplant, immunotherapy, and cellular therapies for hematologic malignancies. Here we review the mechanisms by which microbiotas influence hematopoiesis in development and adulthood as well as the avenues by which microbiotas are thought to impact stem cell transplant engraftment, graft-versus-host disease, and efficacy of cell and immunotherapies. We highlight areas of future research that may lead to reduced adverse effects of antibiotic use and improved outcomes for patients with hematologic conditions.
Fellows’ Corner
Authors: Robert M. Wilechansky
Journal: Hepatology (2023)

1Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA 2Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA Abbreviations: AIH, autoimmune hepatitis; HPS, hepatopulmonary syndrome; LT, liver transplantation; p-TIPS, preemptive transjugular portosystemic shunt. Correspondence Robert M. Wilechansky, Massachusetts General Hospital, 15 Parkman St., Wang 5, Boston, MA 02114. Email: [email protected]
Role of augmented reality in surgery: editorial
Authors: Hitesh Chopra, Kavita Munjal, Sonia Arora, Shabana Bibi, Partha Biswas
Journal: International Journal of Surgery (2024)

Chopra, Hitesh PhD; Munjal, Kavita PhD; Arora, Sonia PhD; Bibi, Shabana; Biswas, Partha MSC Author Information
Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor
Authors: Congyi Shen, Jian Wang, Guangfeng Li, Shuyue Hao, Yan Wu, Peiran Song, Yafei Han, Mengmeng Li, Guangchao Wang, Ke Xu, Hao Zhang, Xiaoxiang Ren, Yingying Jing, Ru Yang, Zhen Geng, Jiacan Su
Journal: Bioactive Materials (2024)

Osteoarthritis (OA), a common degenerative disease, is characterized by high disability and imposes substantial economic impacts on individuals and society. Current clinical treatments remain inadequate for effectively managing OA. Organoids, miniature 3D tissue structures from directed differentiation of stem or progenitor cells, mimic native organ structures and functions. They are useful for drug testing and serve as active grafts for organ repair. However, organoid construction requires extracellular matrix-like 3D scaffolds for cellular growth. Hydrogel microspheres, with tunable physical and chemical properties, show promise in cartilage tissue engineering by replicating the natural microenvironment. Building on prior work on SF-DNA dual-network hydrogels for cartilage regeneration, we developed a novel RGD-SF-DNA hydrogel microsphere (RSD-MS) via a microfluidic system by integrating photopolymerization with self-assembly techniques and then modified with Pep-RGDfKA. The RSD-MSs exhibited uniform size, porous surface, and optimal swelling and degradation properties.
T cell help shapes B cell tolerance
Authors: Elliot H. Akama-Garren, Xihui Yin, Tyler R. Prestwood, Minghe Ma, Paul J. Utz, Michael C. Carroll
Journal: Science Immunology (2024)

T cell help is a crucial component of the normal humoral immune response, yet whether it promotes or restrains autoreactive B cell responses remains unclear. Here, we observe that autoreactive germinal centers require T cell help for their formation and persistence. Using retrogenic chimeras transduced with candidate TCRs, we demonstrate that a follicular T cell repertoire restricted to a single autoreactive TCR, but not a foreign antigen–specific TCR, is sufficient to initiate autoreactive germinal centers. Follicular T cell specificity influences the breadth of epitope spreading by regulating wild-type B cell entry into autoreactive germinal centers. These results demonstrate that TCR-dependent T cell help can promote loss of B cell tolerance and that epitope spreading is determined by TCR specificity.
A commentary on ‘Percutaneous endoscopic lumbar discectomy for recurrent lumbar disc herniation’
Authors: Runhan Zhao, Ningdao Li, Xiaoji Luo
Journal: International Journal of Surgery (2024)

Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, P.R. China Runhan Zhao, Ningdao Li, These authors contributed equally to the work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: 1 Youyi Road, Yuzhong, Chongqing, 400016, P.R. China. E-mail address: [email protected] (X. Luo). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Regarding the association of systemic inflammatory markers and tertiary lymphoid structure with pathological complete response in gastric cancer patients
Authors: Xuefeng Ma, Jing Zhang
Journal: International Journal of Surgery (2024)

Department of Gastroenterology (Ward III), Digestive Endoscopy Center, Central Hospital of Dalian University of Technology, Dalian, Liaoning, China Published online ■ ■ *Corresponding author. Address: Department of Gastroenterology (Ward III), Digestive Endoscopy Center, Central Hospital of Dalian University of Technology 826 Xinan road, Dalian, China, Cell phone: 0086-13387872539, Fax: 0411-84411941. E-mail address: [email protected] (J. Zhang). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
A newly discovered circovirus and its potential impact on human health and disease
Authors: Maria K. da Silva, Shopnil Akash, Jonas G.F. de Aquino, Shahina Akter, Umberto L. Fulco, Jonas I.N. Oliveira
Journal: International Journal of Surgery (2024)

Silva, Maria Karolaynne da; Akash, Shopnil; Aquino, Jonas Galileu Ferreira de; Akter, Shahina; Fulco, Umberto Laino; Ivan Nobre Oliveira, Jonas Author Information
e-Lung Computed Tomography Biomarker Stratifies Patients at Risk of Idiopathic Pulmonary Fibrosis Progression in a 52-Week Clinical Trial
Authors: Anand Devaraj, Finja Ottink, Christian Rennison-Jones, François-Xavier Blé, Olivier Joly, Adnan Azim, Stephen Gerry, George Harston, Kristoffer Ostridge, Peter M. George
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"e-Lung CT Biomarker Stratifies Patients at Risk of IPF Progression in a 52-Week Clinical Trial." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
STING licensing of type I dendritic cells potentiates antitumor immunity
Authors: Jian Wang, Suxin Li, Maggie Wang, Xu Wang, Shuqing Chen, Zhichen Sun, Xiubao Ren, Gang Huang, Baran D. Sumer, Nan Yan, Yang-Xin Fu, Jinming Gao
Journal: Science Immunology (2024)

Stimulator of interferon genes (STING) is an immune adaptor protein that senses cyclic GMP-AMP in response to self or microbial cytosolic DNA as a danger signal. STING is ubiquitously expressed in diverse cell populations, including cancer cells, with distinct cellular functions, such as activation of type I interferons, autophagy induction, or triggering apoptosis. It is not well understood whether and which subsets of immune cells, stromal cells, or cancer cells are particularly important for STING-mediated antitumor immunity. Here, using a polymeric STING-activating nanoparticle (PolySTING) with a shock-and-lock dual activation mechanism, we show that conventional type 1 dendritic cells (cDC1s) are essential for STING-mediated rejection of multiple established and metastatic murine tumors. STING status in the host but not in the cancer cells (
Risk of Anaphylaxis Among New Users of GLP-1 Receptor Agonists: A Cohort Study
Authors: Mary S. Anthony, Vanita R. Aroda, Lauren E. Parlett, Leila Djebarri, Sofia Berreghis, Brian Calingaert, Daniel C. Beachler, Christopher L. Crowe, Catherine B. Johannes, Juhaeri Juhaeri, Stephan Lanes, Chunshen Pan, Kenneth J. Rothman, Catherine W. Saltus, Kathleen E. Walsh
Journal: Diabetes Care (2024)

To assess risk of anaphylaxis among patients with type 2 diabetes mellitus who are initiating therapy with a glucagon-like peptide 1 receptor agonist (GLP-1 RA), with a focus on those starting lixisenatide therapy.
Revolutionizing gastric linitis plastica diagnosis: the crucial role of EUS-FNA in a sequential diagnostic approach
Authors: Ashna Habib, Amisha Kumari, Zainab Nazir, Hamza Irfan, Tooba Ali, Md Ariful Haque
Journal: International Journal of Surgery (2024)

Habib, Ashna; Kumari, Amisha; Nazir, Zainab; Irfan, Hamza; Ali, Tooba; Haque, Md Ariful Author Information
Invasive versus non-invasive paediatric home mechanical ventilation: review of the international evolution over the past 24 years
Authors: Michel Toussaint, Olivier van Hove, Dimitri Leduc, Lise Ansay, Nicolas Deconinck, Brigitte Fauroux, Sonia Khirani
Journal: Thorax (2024)

Background Home mechanical ventilation (HMV) is the treatment for chronic hypercapnic alveolar hypoventilation. The proportion and evolution of paediatric invasive (IMV) and non-invasive (NIV) HMV across the world is unknown, as well as the disorders and age of children using HMV. Methods Search of Medline/PubMed for publications of paediatric surveys on HMV from 2000 to 2023. Results Data from 32 international reports, representing 8815 children (59% boys) using HMV, were analysed. A substantial number of children had neuromuscular disorders (NMD; 37%), followed by cardiorespiratory (Cardio-Resp; 16%), central nervous system (CNS; 16%), upper airway (UA; 13%), other disorders (Others; 10%), central hypoventilation (4%), thoracic (3%) and genetic/congenital disorders (Gen/Cong; 1%). Mean age±SD (range) at HMV initiation was 6.7±3.7 (0.5–14.7) years. Age distribution was bimodal, with two peaks around 1–2 and 14–15 years. The number and proportion of children using NIV was significantly greater than that of children using IMV (n=6362 vs 2453, p=0.03; 72% vs 28%, p=0.048), with wide variations among countries, studies and disorders. NIV was used preferentially in the preponderance of children affected by UA, Gen/Cong, Thoracic, NMD and Cardio-Resp disorders. Children with NMD still receiving primary invasive HMV were mainly type I spinal muscular atrophy (SMA). Mean age±SD at initiation of IMV and NIV was 3.3±3.3 and 8.2±4.4 years (p&lt;0.01), respectively. The rate of children receiving additional daytime HMV was higher with IMV as compared with NIV (69% vs 10%, p&lt;0.001). The evolution of paediatric HMV over the last two decades consists of a growing number of children using HMV, in parallel to an increasing use of NIV in recent years (2020–2023). There is no clear trend in the profile of children over time (age at HMV). However, an increasing number of patients requiring HMV were observed in the Gen/Cong, CNS and Others groups. Finally, the estimated prevalence of paediatric HMV was calculated at 7.4/100 000 children. Conclusions Patients with NMD represent the largest group of children using HMV. NIV is increasingly favoured in recent years, but IMV is still a prevalent intervention in young children, particularly in countries indicating less experience with NIV.
COVID-19 in Pediatric Patients With Acute Lymphoblastic Leukemia or Lymphoma
Authors: Saman K. Hashmi, Jessica Bodea, Tushar Patni, Savannah Angel, Nickhill H. Bhakta, Sima Jeha, Seth E. Karol, Raul C. Ribeiro, Jeffrey E. Rubnitz, Joshua Wolf, Yimei Li, Ching-Hon Pui, Diego R. Hijano, Hiroto Inaba
Journal: JAMA Network Open (2024)

Importance COVID-19 in pediatric patients with acute lymphoblastic leukemia or lymphoma (ALL/LLy) has not been described in detail and may affect chemotherapy administration and long-term outcomes. Objective To describe the clinical presentation of COVID-19 and chemotherapy modifications in pediatric patients with ALL/LLy. Design, Setting, and Participants This is a retrospective case series of patients at St Jude Children’s Research Hospital and its affiliate sites with newly diagnosed ALL/LLy who were treated on the Total XVII protocol (NCT03117751) between March 30, 2020, and June 20, 2022. Participants included patients aged 1 to 18 years who were receiving protocol chemotherapy. Acute symptoms and chemotherapy modifications were evaluated for 60 days after the COVID-19 diagnosis, and viral clearance, adverse events, and second SARS-CoV-2 infections were followed up during the 27-month study period. Exposures SARS-CoV-2; all patients were screened at least weekly and at symptom onset and/or after known exposure to SARS-CoV-2. Main Outcomes and Measures Description of the spectrum of COVID-19 illness and chemotherapy modifications. Results Of 308 pediatric patients, 110 (36%) developed COVID-19 at a median age of 8.2 (IQR, 5.3-14.5) years. Sixty-eight patients (62%) were male. Most patients were in the continuation/maintenance phase of chemotherapy (101 [92%]). Severe disease was rare (7 [6%]) but was associated with older age, higher white blood cell counts at ALL/LLy diagnosis, lower absolute lymphocyte counts at COVID-19 diagnosis, abnormal chest imaging findings, and SARS-CoV-2 reinfection. Rare but serious thrombotic events included pulmonary embolism and cerebral venous sinus thrombosis (n = 1 for each). No multisystem inflammatory syndrome in children or death was seen. SARS-CoV-2 reinfection occurred in 11 patients (10%) and was associated with older age and with receiving standard or high-risk vs low-risk ALL/LLy therapy. Chemotherapy interruptions occurred in 96 patients (87%) and were longer for patients with severe disease, SARS-CoV-2 reinfection, and/or a COVID-19 diagnosis during the pre-Omicron variant period vs the post-Omicron period (after December 27, 2021). Conclusions and Relevance In this case series of COVID-19 in pediatric patients with ALL/LLy, severe COVID-19 was rare, but chemotherapy administration was affected in most patients. Long-term studies are needed to establish the outcomes of COVID-19 in this population.
Teaching and Safety-Net Hospital Penalization in the Hospital-Acquired Condition Reduction Program
Authors: Jose A. Serpa, Gretchen Gemeinhardt, Cesar A. Arias, Robert O. Morgan, Heidi Russell, Hongyu Miao, Cecilia M. Ganduglia Cazaban
Journal: JAMA Network Open (2024)

Importance The Hospital-Acquired Condition Reduction Program (HACRP) evaluates acute care hospitals on the occurrence of patient safety events and health care–associated infections. Since its implementation, several studies have raised concerns about the overpenalization of teaching and safety-net hospitals, and although several changes in the program’s methodology have been applied in the last few years, whether these changes reversed the overpenalization of teaching and safety-net hospitals is unknown. Objective To determine hospital characteristics associated with HACRP penalization and penalization reversal. Design, Setting, and Participants This retrospective cross-sectional study assessed data from 3117 acute care hospitals participating in the HACRP. The HACRP penalization and hospital characteristics were obtained from Hospital Compare ( 2020 and 2021), the Inpatient Prospective Payment System impact file ( 2020 ), and the American Hospital Association annual survey (2018). Exposures Hospital characteristics, including safety-net status and teaching intensity (no teaching and very minor, minor, major, and very major teaching levels). Main Outcomes and Measures The primary outcome was HACRP penalization (ie, hospitals that fell within the worst quartile of the program’s performance). Multivariable models initially included all covariates, and then backward stepwise variable selection was used. Results Of 3117 hospitals that participated in HACRP in 2020, 779 (25.0%) were safety-net hospitals and 1090 (35.0%) were teaching institutions. In total, 771 hospitals (24.7%) were penalized. The HACRP penalization was associated with safety-net status (odds ratio [OR], 1.41 [95% CI, 1.16-1.71]) and very major teaching intensity (OR, 1.94 [95% CI, 1.15-3.28]). In addition, non–federal government hospitals were more likely to be penalized than for-profit hospitals (OR, 1.62 [95% CI, 1.23-2.14]), as were level I trauma centers (OR, 2.05 [95% CI, 1.43-2.96]) and hospitals located in the New England region (OR, 1.65 [95% CI, 1.12-2.43]). Safety-net hospitals with major teaching levels were twice as likely to be penalized as non–safety-net nonteaching hospitals (OR, 2.15 [95% CI, 1.14-4.03]). Furthermore, safety-net hospitals penalized in 2020 were less likely (OR, 0.64 [95% CI, 0.43-0.96]) to revert their HACRP penalization status in 2021. Conclusions and Relevance Findings from this cross-sectional study indicated that teaching and safety-net hospital status continued to be associated with overpenalization in the HACRP despite recent changes in its methodology. Most of these hospitals were also less likely to revert their penalization status. A reevaluation of the program methodology is needed to avoid depleting resources of hospitals caring for underserved populations.
RNA Injection Every 6 Months to Improve Adherence and Lower Blood Pressure in Patients With Hypertension
Authors: Ernesto L. Schiffrin
Journal: JAMA (2024)

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Psychotropic Polypharmacy Among Youths Enrolled in Medicaid
Authors: Yueh-Yi Chiang, Alejandro Amill-Rosario, Phuong Tran, Susan dosReis
Journal: JAMA Network Open (2024)

This cross-sectional study aims to identify temporal changes and characteristics associated with psychotropic polypharmacy among youths aged 17 years or younger who were enrolled in Medicaid in Maryland.
Chemotherapy Delays Due to SARS-CoV-2 Infection in Children With Leukemia or Lymphoma
Authors: Jenny Ruiz, Zachary Aldewereld, Caitlin Elgarten
Journal: JAMA Network Open (2024)

Saman K. Hashmi, MD; Jessica Bodea, MD; Tushar Patni, MS; Savannah Angel, BS; Nickhill H. Bhakta, MD, MPH; Sima Jeha, MD; Seth E. Karol, MD; Raul C. Ribeiro, MD; Jeffrey E. Rubnitz, MD, PhD; Joshua Wolf, MBBS, PhD; Yimei Li, PhD; Ching-Hon Pui, MD; Diego R. Hijano, MD, MSc; Hiroto Inaba, MD, PhD