tbuckley/cabot-search huggingface dataset:
Predictive value of NT-proBNP and hs-TnT for outcomes after pediatric congenital cardiac surgery
Authors: Huayan Shen, Qiyu He, Xinyang Shao, Ya-hui Lin, Dongdong Wu, Kai Ma, Zheng Dou, Yuze Liu, Fengming Luo, Shoujun Li, Zhou Zhou
Journal: International Journal of Surgery (2024)

Background: The available evidence regarding the predictive value of troponins and natriuretic peptides for early postoperative outcomes in pediatrics is limited, controversial, and based on small sample sizes. We aimed to investigate the association of N-terminal pro B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-TnT) with the in-hospital adverse outcomes after congenital cardiac surgeries. Methods: A secondary analysis based on a prospective study of pediatric congenital heart disease (CHD) patients was conducted to investigate the association of NT-proBNP and hs-TnT tested within 6 hours postoperatively with in-hospital adverse events. A multivariate logistic regression analysis with a minimum P value approach was used to identify the optimal thresholds of NT-proBNP and hs-TnT for risk stratification. Results: NT-proBNP and hs-TnT are positively correlated with cardiopulmonary bypass time, mechanical ventilation duration, and pediatric intensive care unit stay. The predictive performance of NT-proBNP is excellent for adverse events in both patients younger than 1 year [area under the curve (AUC): 0.771, 0.693-0.850] and those older than 1 year (AUC: 0.839, 0.757-0.922). However, hs-TnT exhibited a satisfactory predictive value solely in patients aged over 1 year. (AUC: 0.784, 0.717-0.852). NT-proBNP levels of 2000 to 10000 ng/L [Odds Ratio (OR): 3.79, 1.47-9.76) and exceeding 10000 ng/L (OR: 12.21, 3.66-40.80) were associated with a higher risk of postoperative adverse events in patients younger than 1 year. Patients older than 1 year, with NT-proBNP higher than 500 ng/L (OR: 15.09, 6.05-37.66) or hs-TnT greater than 1200 ng/L (OR: 5.50, 1.47-20.59), had a higher incidence of postoperative adverse events. Conclusions: NT-proBNP and hs-TnT tested within postoperative 6 hours demonstrated significant predictive value for postoperative adverse events in CHD patients older than 1 year. However, among CHD patients younger than 1 year, only NT-proBNP exhibited commendable predictive performance for postoperative adverse events.
RARPKB: a knowledge-guide decision support platform for personalized robot-assisted surgery in prostate cancer
Authors: Jiakun Li, Tong Tang, Erman Wu, Jing Zhao, Hui Zong, Rongrong Wu, Weizhe Feng, Ke Zhang, Dongyue Wang, Yawen Qin, Zheng Shen, Yi Qin, Shumin Ren, Chaoying Zhan, Lu Yang, Qiang Wei, Bairong Shen
Journal: International Journal of Surgery (2024)

Background: Robot-assisted radical prostatectomy (RARP) has emerged as a pivotal surgical intervention for the treatment of prostate cancer. However, the complexity of clinical cases, heterogeneity of prostate cancer, and limitations in physician expertise pose challenges to rational decision-making in RARP. To address these challenges, we aimed to organize the knowledge of previously complex cohorts and establish an online platform named the RARP Knowledge Base (RARPKB) to provide reference evidence for personalized treatment plans. Materials and Methods: PubMed searches over the past two decades were conducted to identify publications describing RARP. We collected, classified, and structured surgical details, patient information, surgical data, and various statistical results from the literature. A knowledge-guided decision-support tool was established using MySQL, DataTable, ECharts, and JavaScript. ChatGPT-4 and two assessment scales were used to validate and compare the platform. Results: The platform comprised 583 studies, 1589 cohorts, 1 911 968 patients, and 11 986 records, resulting in 54 834 data entries. The knowledge-guided decision support tool provide personalized surgical plan recommendations and potential complications on the basis of patients’ baseline and surgical information. Compared with ChatGPT-4, RARPKB outperformed in authenticity (100% versus [vs.] 73%), matching (100% vs. 53%), personalized recommendations (100% vs. 20%), matching of patients (100% vs. 0%), and personalized recommendations for complications (100% vs. 20%). Post-use, the average System Usability Scale score was 88.88±15.03, and the Net Promoter Score of RARPKB was 85. The knowledge base is available at http://rarpkb.bioinf.org.cn. Conclusions: We introduced the pioneering RARPKB, the first knowledge base for robot-assisted surgery, with an emphasis on prostate cancer. RARPKB can assist in personalized and complex surgical planning for prostate cancer to improve its efficacy. RARPKB provides a reference for the future applications of artificial intelligence in clinical practice.
Correction to: Pharmacological Management of Cardiac Arrhythmias in the Fetal and Neonatal Periods: A Scientific Statement From the American Heart Association
Journal: Circulation (2024)

Figure 5: • The third row, the second box from the left read, "Rapid push of adenosine 0.3-4 mg/kg IV. " It has been updated to read, "Rapid push of adenosine 0.3-0.4mg/kg IV. " • The fourth row, first box on the left, the fourth line read, "Procainamide 15 mg/kg IV OR.... " It has been updated to read, "Procainamide 10 mg/kg IV OR....
Smoking-related<i>Lactobacillus</i>and immune cell infiltration in colorectal cancer: evidence from a population-based study
Authors: Silu Chen, Junyi Xin, Dongying Gu, Huiqin Li, Rui Zheng, Shuwei Li, Zhengdong Zhang, Mulong Du, Meilin Wang
Journal: Gut (2024)
The anterior neck scar outcomes of conventional thyroidectomy using a wound protector: a multicenter double-blinded randomized controlled trial
Authors: Woochul Kim, Hyeong Won Yu, Su-jin Kim, Young Jun Chai, June Young Choi, Kyu Eun Lee
Journal: International Journal of Surgery (2024)

Purpose: This study aimed to investigate the effectiveness of a novel wound protector in enhancing the cosmetic outcomes of thyroidectomy. Material and Methods: This multicenter, double-blinded randomized controlled trial enrolled 129 patients undergoing open thyroidectomy. The patients were divided into a wound protector group and a control group. Subjective patient assessments were conducted, measuring wound satisfaction, pain, and itchiness. Additionally, blinded observers evaluated scars using the Vancouver Scar Scale. Results: The Vancouver Scar Scale revealed significant advantages for the wound protector group, demonstrating improvements in pigmentation ( P =0.002), vascularity ( P =0.014), pliability ( P =0.001), and height ( P =0.001). Conclusion: The thyroid wound protector offers a potential to improve post-operative cosmetic outcomes. Further research is warranted to explore patient experiences and optimize the application of this innovative wound protector across diverse surgical contexts.
Comment on ‘Change of indocyanine green clearance ability and liver function after transcatheter intraarterial therapies and its impact on outcomes of resectable hepatocellular carcinoma: a retrospective cohort study’
Authors: Wenming Feng, Chengwu Tang
Journal: International Journal of Surgery (2024)

Department of General Surgery, First affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China Running Title: transcatheter intraarterial therapies and resectable hepatocellular carcinoma. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding Author. Address: Chengwu Tang, MD, Department of General Surgery, First affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China. E-mail address: [email protected] This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Safety and efficacy of givinostat in boys with Duchenne muscular dystrophy (EPIDYS): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
Authors: Eugenio Mercuri, Juan J Vilchez, Odile Boespflug-Tanguy, Craig M Zaidman, Jean K Mah, Nathalie Goemans, Wolfgang Müller-Felber, Erik H Niks, Ulrike Schara-Schmidt, Enrico Bertini, Giacomo P Comi, Katherine D Mathews, Laurent Servais, Krista Vandenborne, Jessika Johannsen, Sonia Messina, Stefan Spinty, Laura McAdam, Kathryn Selby, Barry Byrne, Chamindra G Laverty, Kevin Carroll, Giulia Zardi, Sara Cazzaniga, Nicoletta Coceani, Paolo Bettica, Craig M McDonald, Gyula Acsadi, Giovanni Baranello, Astrid Blaschek, John Brandsema, Claudia Brogna, Claudio Bruno, Anne Connolly, Imelda de Groot, Liesbeth De Waele, Erika Finanger, Richard Finkel, Teresa Gidaro, Michaela Guglieri, Amy Harper, Mercedes Lopez Lobato, Marcos Madruga Garrido, Francesca Magri, Georgios Manousakis, Riccardo Masson, Migvis Monduy, Nuria Muelas Gomez, Francina Munell, Andres Nascimento, Yoram Nevo, Yann Pereon, Han Phan, Valeria Sansone, Mariacristina Scoto, Dragana Vucinic, Tracey Willis
Journal: The Lancet Neurology (2024)
Safety and immunogenicity of the co-administered Na-APR-1 and Na-GST-1 hookworm vaccines in school-aged children in Gabon: a randomised, controlled, observer-blind, phase 1, dose-escalation trial
Authors: Jeannot F Zinsou, David J Diemert, Jean Claude Dejon-Agobé, Bayodé R Adégbité, Yabo Josiane Honkpehedji, Kafui G Vodonou, Rodrigue Bikangui, Jean Ronald Edoa, Marguerite Massinga Loembe, Guangzhao Li, Maria Yazdanbakhsh, Maria Elena Bottazzi, Remko van Leeuwen, Peter G Kremsner, Peter J Hotez, Jeffrey M Bethony, Martin P Grobusch, Ayola A Adegnika
Journal: The Lancet Infectious Diseases (2024)
Effects of mitral valve disease etiology on the outcomes of mechanical and biological valve replacement: retrospective cohort study
Authors: Chun-Yu Chen, Feng-Cheng Chang, Chia-Pin Lin, Yi-Hsin Chan, Victor Chien-Chia Wu, Yu-Ting Cheng, Pao-Hsien Chu, An-Hsun Chou, Chi-Hsiao Yeh, Shao-Wei Chen
Journal: International Journal of Surgery (2024)

Introduction: The choice of an artificial mitral valve (MV) is a crucial clinical decision that affects the long-term survival and quality of life of patients. However, current guidelines recommend selecting MV based on patient age and life expectancy at the time of MV replacement (MVR), without considering the etiology of MV disease. This study aimed to investigate whether MV disease etiology should be considered when choosing a valve for MVR and to evaluate the impact of MV disease etiology on long-term patient survival. Methods: Using data (2002 to 2018) from Taiwan’s National Health Insurance Research Database, we conducted a nationwide retrospective cohort study to compare the biological and mechanical valves in terms of all-cause mortality as the primary outcome. The inverse probability of the treatment weighting method was used to reduce the effects of the confounding factors. The following etiologies were assessed: infective endocarditis (IE), rheumatic heart disease (RHD), ischemic mitral regurgitation (IMR), and degenerative mitral regurgitation (DMR). Results: In patients aged &lt;70 years, it was observed that mechanical valves demonstrated an association with benefits compared to biological valves in the context of survival. In patients with IE aged &lt;72 years, mechanical valves were associated with survival benefits, but not in those with stroke during hospitalization. These valves were also found to be linked with survival advantages for patients with RHD aged &lt;60 years and for those with DMR aged &lt; 72 years. However, no age-dependent effects of valve type on all-cause mortality were observed in patients with IMR. Conclusion: The etiology of MV disease appears to be important in the selection of a suitable MV and determination of a cutoff age for mechanical and biological MVR.
The impact of using near-infrared autofluorescence on parathyroid gland parameters and clinical outcomes during total thyroidectomy: a meta-analytic study of randomized controlled trials
Authors: Alaa Safia, Uday Abd Elhadi, Saqr Massoud, Shlomo Merchavy
Journal: International Journal of Surgery (2024)

The added benefit of using near-infrared autofluorescence (NIRAF) during total thyroidectomy (TT) remains controversial. This study investigated whether or not NIRAF results in improved patient outcomes postoperatively.
Outcome variation and the role of caseload in certified colorectal cancer centers – a retrospective cohort analysis of 90 000 cases
Authors: Richard Hunger, Christoph Kowalski, Christoph Paasch, Jette Kirbach, Rene Mantke
Journal: International Journal of Surgery (2024)

Background: Studies have shown that surgical treatment of colorectal carcinomas in certified centers leads to improved outcomes. However, there were considerable fluctuations in outcome parameters. It has not yet been examined whether this variability is due to continuous differences between hospitals or variability within a hospital over time. Materials and Methods: In this retrospective observational cohort study, administrative quality assurance data of 153 German-certified colorectal cancer centers between 2010 and 2019 were analyzed. Six outcome quality indicators (QI) were studied: 30-day postoperative mortality rate (POM), surgical site infection rate (SSI), anastomotic insufficiency rate (AI), and revision surgery rate (RS). AI and RS were also analyzed for colon (C) and rectal cancer operations (R). Variability was analyzed by funnel plots with 95% and 99% control limits and modified Cleveland dot plots. Results: In the 153 centers 90,082 patients with colon cancer and 47,623 patients with rectal cancer were treated. Average QI scores were 2.7% POM, 6.2% SSI, 4.8% AI-C, 8.5% AI-R, 9.1% RS-C, and 9.8% RS-R. The funnel plots revealed that for every QI about 10.1% of hospitals lay above the upper 99% and about 8.7% below the lower 99% control limit. In POM, SSI, and AI-R, a significant negative correlation with the average annual caseload was observed. Conclusion: The analysis showed high variability in outcome quality between and within the certified colorectal cancer centers. Only a small number of hospitals had a high performance on all six quality indicators, suggesting that significant quality variation exists even within the group of certified centers.
Activation of GPR81 by lactate drives tumour-induced cachexia
Authors: Xidan Liu, Shijin Li, Qionghua Cui, Bujing Guo, Wanqiu Ding, Jie Liu, Li Quan, Xiaochuan Li, Peng Xie, Li Jin, Ye Sheng, Wenxin Chen, Kai Wang, Fanxin Zeng, Yifu Qiu, Changlu Liu, Yan Zhang, Fengxiang Lv, Xinli Hu, Rui-Ping Xiao
Journal: Nature Metabolism (2024)

Abstract Cachexia affects 50–80% of patients with cancer and accounts for 20% of cancer-related death, but the underlying mechanism driving cachexia remains elusive. Here we show that circulating lactate levels positively correlate with the degree of body weight loss in male and female patients suffering from cancer cachexia, as well as in clinically relevant mouse models. Lactate infusion per se is sufficient to trigger a cachectic phenotype in tumour-free mice in a dose-dependent manner. Furthermore, we demonstrate that adipose-specific G-protein-coupled receptor (GPR)81 ablation, similarly to global GPR81 deficiency, ameliorates lactate-induced or tumour-induced adipose and muscle wasting in male mice, revealing adipose GPR81 as the major mediator of the catabolic effects of lactate. Mechanistically, lactate/GPR81-induced cachexia occurs independently of the well-established protein kinase A catabolic pathway, but it is mediated by a signalling cascade sequentially activating Gi–Gβγ–RhoA/ROCK1–p38. These findings highlight the therapeutic potential of targeting GPR81 for the treatment of this life-threatening complication of cancer.
Clinical efficacy of different surgical approaches in the treatment of thoracolumbar tuberculosis: a multicenter retrospective case–control study with a minimum 10-year follow-up
Authors: Renfeng Liu, Jinpeng He, Qizhi Fan, Hao Zhou, Xin Wu, Zuyun Yan, Wei Tan, Xiaofang Zang, Deng Youwen
Journal: International Journal of Surgery (2024)

Objective: To evaluate the long-term clinical efficacy of three different surgical approaches in treating thoracolumbar tuberculosis. Methods: A total of 176 patients with thoracolumbar tuberculosis, treated with open surgery at two hospitals, were retrospectively analyzed. Patients were stratified into three groups based on the surgical approach: anterior-only (AO), posterior-only (PO), and anterior–posterior combined (AP) approaches. Collected data encompassed operative duration, intraoperative blood loss, hospital stay length, complications, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Visual Analog Scale (VAS) score, Oswestry Disability Index (ODI), American Spinal Injury Association (ASIA) classification, and radiographic measurements of segmental lordotic Cobb angles, correction angles, and correction rates. Results: The minimum duration of follow-up among all patients was 10 years. Postoperatively, all patients experienced a reduction in ESR and CRP, with normalization occurring within 3 months and sustained normal at the last follow-up. The AP group had a longer operative duration and higher intraoperative blood loss than the other two groups. The Cobb correction rates for AO, PO, and AP were (56.33±6.62)%, (72.82±5.66)%, and (74.45±5.78)%, respectively. The correction loss of Cobb angles for AO, PO, and AP were (2.85±1.01)°, (1.42±0.97)°, and (1.19±0.89)°, respectively. Patients in all groups showed significant improvement in VAS scores and ODI postoperatively, with no notable intergroup differences. The neurological recovery rates for the AO, PO, and AP groups were 84.62, 87.10, and 83.72%, respectively, while the complication rates were 12.73, 16.98, and 22.06%, respectively. Conclusion: An anterior-only approach is recommended for cases with localized lesions and smaller angular deformities. For patients with multisegmental lesions and larger angular deformities, a posterior-only or anterior–posterior combined approach is advised, with a preference for the posterior-only approach.
Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors
Authors: Marije Niemeijer, Witold Więcek, Shuai Fu, Suzanna Huppelschoten, Peter Bouwman, Audrey Baze, Céline Parmentier, Lysiane Richert, Richard S. Paules, Frederic Y. Bois, Bob van de Water
Journal: Environmental Health Perspectives (2024)

Understanding the variability across the human population with respect to toxicodynamic responses after exposure to chemicals, such as environmental toxicants or drugs, is essential to define safety factors for risk assessment to protect the entire population. Activation of cellular stress response pathways are early adverse outcome pathway (AOP) key events of chemical-induced toxicity and would elucidate the estimation of population variability of toxicodynamic responses.
Metabolic Syndrome Traits Increase the Risk of Major Adverse Liver Outcomes in Type 2 Diabetes
Authors: Ying Shang, Emilie Toresson Grip, Angelo Modica, Helena Skröder, Oskar Ström, Fady Ntanios, Soffia Gudbjörnsdottir, Hannes Hagström
Journal: Diabetes Care (2024)

OBJECTIVE Type 2 diabetes (T2D) increases the risk for major adverse liver outcomes (MALOs), including cirrhosis and its complications. Patients with T2D frequently have other traits of the metabolic syndrome (MetS). It remains uncertain whether there is a synergistic effect of accumulating MetS traits on future MALO risk. RESEARCH DESIGN AND METHODS Patients with T2D without a history of liver disease were identified from national registers in Sweden from 1998 to 2021. MetS traits included hypertension, low HDL level, hypertriglyceridemia, obesity, and albuminuria, in addition to T2D. MALO events were identified based on administrative coding from national registers until 31 October 2022. Data were analyzed using Cox regression models. RESULTS In total, 230,992 patients were identified (median age 64 years; 58% male), of whom 3,215 (1.39%) developed MALOs over a median follow-up of 9.9 years. Compared with patients with one MetS trait (only T2D) at baseline, those with more than one MetS trait had a higher rate of MALOs (adjusted hazard ratio [aHR] 2.33, 95% CI 1.53–3.54). The rate of MALOs increased progressively with increasing numbers of MetS traits at baseline (aHR 1.28 per added trait, 95% CI 1.23–1.33). During follow-up, patients who acquired additional MetS traits had a progressively higher rate of MALOs. The MetS trait with the largest association with incident MALOs was hypertension (aHR 2.06, 95% CI 1.57–2.71). CONCLUSIONS Having or acquiring additional traits of MetS increase the rate of progression to MALOs in patients with T2D. These results could be used to inform screening initiatives for liver disease.
Evaluating reliability in wearable devices for sleep staging
Authors: Vera Birrer, Mohamed Elgendi, Olivier Lambercy, Carlo Menon
Journal: npj Digital Medicine (2024)

Abstract Sleep is crucial for physical and mental health, but traditional sleep quality assessment methods have limitations. This scoping review analyzes 35 articles from the past decade, evaluating 62 wearable setups with varying sensors, algorithms, and features. Our analysis indicates a trend towards combining accelerometer and photoplethysmography (PPG) data for out-of-lab sleep staging. Devices using only accelerometer data are effective for sleep/wake detection but fall short in identifying multiple sleep stages, unlike those incorporating PPG signals. To enhance the reliability of sleep staging wearables, we propose five recommendations: (1) Algorithm validation with equity, diversity, and inclusion considerations, (2) Comparative performance analysis of commercial algorithms across multiple sleep stages, (3) Exploration of feature impacts on algorithm accuracy, (4) Consistent reporting of performance metrics for objective reliability assessment, and (5) Encouragement of open-source classifier and data availability. Implementing these recommendations can improve the accuracy and reliability of sleep staging algorithms in wearables, solidifying their value in research and clinical settings.