tbuckley/cabot-search huggingface dataset:
Recent Progress and Opportunities of Wearable Non‐Invasive Epidermal Sensors for Skin Disease Diagnosis
Authors: Jin Xu, Ye Huang, Zhihui Zhao, Duojia Wang, Chao Yang, Kewei Zhang
Journal: Advanced Healthcare Materials (2024)

With deteriorating environment and increased stress in modern life, skin diseases have become the fourth leading cause of nonfatal and chronic diseases. An early diagnosis might improve the chances of a successful treatment. Wearable epidermal sensors have been emerged as new non-invasive tools for clinical practice and research in dermatology, which can act as a complement to the otherwise mostly visual and tactile judgments. This review discusses the recent progress and opportunities of wearable epidermal sensors for skin disease diagnosis. The configuration, material choice, and fundamental platforms of wearable epidermal sensors are first summarized. Then, their emerging application in monitoring skin diseases is demonstrated by detecting skin hardness, skin hydration, and biomakers. With the advances highlighted here and the ongoing research efforts, the continuous breakthrough in wearable epidermal sensors and their attractive application in skin disease management is foreseeable in the future.
Kirigami‐Inspired Stretchable Piezoelectret Sensor for Analysis and Assessment of Parkinson's Tremor
Authors: Qisen Xie, Liuyang Han, Jie Liu, Wenjie Zhang, Liuyan Zhao, Yuhan Liu, Yanru Chen, Yuzhen Li, Qian Zhou, Ying Dong, Xiaohao Wang
Journal: Advanced Healthcare Materials (2024)

Abstract Human muscle activity contains rich information that can reflect human movement patterns and conditions of diseases or physical abnormalities. Flexible pressure sensors enable the assessment of muscle tremors in Parkinson's disease (PD) through Force Myography (FMG). Here, an easily fabricated, ultra‐sensitive, and stretchable piezoelectret pressure sensor is presented. Utilizing an effective integration of Kirigami structure and piezoelectret air gap, the sensor achieved a dynamic sensitivity of ≈725 pC/N (@5 Hz), measurement repeatability of &lt;2.5%, measurement hysteresis of &lt;1%, a pressure detection limit of &lt;15 Pa, a response time of ≈2.5 ms, stable output within ±3% over 40 000 cycles, and output decay of &lt;2.5% after 1000 cycles of complex deformation, meeting non‐distorted measurement conditions up to 20 Hz. Successful monitoring and assessment of hand muscle tremors are demonstrated. Furthermore, using a 1×3 sensor array enabled tremor localization, achieving a high accuracy rate of 99.5% with machine learning algorithms. Additionally, the sensor facilitated the experimental quantification and assisted scoring of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS), with an accuracy of ≈85%. The sensor demonstrates potential for assisting in the diagnosis and rehabilitation monitoring of Parkinson's disease.
Blockade of purine metabolism reverses macrophage immunosuppression and enhances anti-tumor immunity in non-small cell lung cancer
Authors: Li Yang, Aitian Li, Weina Yu, Huishang Wang, Lei Zhang, Dan Wang, Ying Wang, Ru Zhang, Qingyang Lei, Zhangnan Liu, Shanshan Zhen, Haiming Qin, Yaqing Liu, Yang Yang, Xian-Lu Song, Yi Zhang
Journal: Drug Resistance Updates (2024)
Corrigendum to “Golgi-customized Trojan horse nanodiamonds impair GLUT1 plasma membrane localization and inhibit tumor glycolysis [371 (2024) 338–350]”
Authors: Bei Kang, Haobo Wang, Huaqing Jing, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Vojtech Adam, Nan Li
Journal: Journal of Controlled Release (2024)
Amniotic fluid stem cell extracellular vesicles promote lung development via TGF-beta modulation in a fetal rat model of oligohydramnios
Authors: Fabian Doktor, Rebeca Lopes Figueira, Victoria Fortuna, George Biouss, Kaya Stasiewicz, Mikal Obed, Kasra Khalaj, Lina Antounians, Augusto Zani
Journal: Journal of Controlled Release (2024)
Self-assembling nanoparticles for delivery of miR-603 and miR-221 in glioblastoma as a new strategy to overcome resistance to temozolomide
Authors: Marianna Abate, Manuela Porru, Virginia Campani, Carlo Leonetti, Valeria Nele, Rossella Di Paola, Marco De Martino, Margherita Russo, Madhura Tathode, Alessia Maria Cossu, Marco Bocchetti, Alessia Angelillo, Monica Ianniello, Nadia Petrillo, Giovanni Savarese, Rosa Della Monica, Lorenzo Chiariotti, Raffaele Addeo, Michele Caraglia, Giuseppe De Rosa, Silvia Zappavigna
Journal: Journal of Controlled Release (2024)
Enhancing Fracture Healing with 3D Bioprinted Hif1a‐Overexpressing BMSCs Hydrogel: A Novel Approach to Accelerated Bone Repair
Authors: Jiajia Lu, Xiaojian Shi, Zhibin Zhou, Nan Lu, Guangxin Chu, Hai Jin, Lei Zhu, Aimin Chen
Journal: Advanced Healthcare Materials (2024)

Abstract Addressing the urgent need for effective fracture treatments, this study investigates the efficacy of a 3D bioprinted biomimetic hydrogel, enriched with bone marrow mesenchymal stem cells (BMSCs) and targeted hypoxia‐inducible factor 1 alpha (Hif1a) gene activation, in enhancing fracture healing. A photocross‐linkable bioink, gelatin methacryloyl bone matrix anhydride (GBMA) is developed, and selected its 5% concentration for bioink formulation. Rat BMSCs are isolated and combined with GBMA to create the GBMA@BMSCs bioink. This bioink is then used in 3D bioprinting to fabricate a hydrogel for application in a rat femoral fracture model. Through transcriptome sequencing, WGCNA, and Venn analysis, the hypoxia‐inducible factor Hif1a is identified as a critical gene in the fracture healing process. In vitro studies showed that Hif1a promoted BMSC proliferation, chondrogenic differentiation, and cartilage matrix stability. The in vivo application of the GBMA@BMSCs hydrogel with Hif1a overexpression significantly accelerated fracture healing, evidenced by early and enhanced cartilage callus formation. The study demonstrates that 3D bioprinting of GBMA@BMSCs hydrogel, particularly with Hif1a‐enhanced BMSCs, offers a promising approach for rapid and effective fracture repair.
Casting New Light on the Retinol and Retinyl Palmitate Functions as Chemical Enhancers for Transdermal/Topical Drug Delivery
Authors: Yun‐Hao Ren, Qi Zhou, Yang Xu, Bei‐Ning Xu, Peng Shu, Li‐Hua Peng
Journal: Advanced Healthcare Materials (2024)

Abstract Retinol and retinyl palmitate, with excellent whitening and antioxidant activities, are widely used as essential functional ingredients in transdermal preparations and skincare products. Herein, for the first time, the influence and underlying mechanisms of retinol and retinyl palmitate on the skin penetration of caffeine are investigated. It is found that the penetration of caffeine is very significantly enhanced by retinol and retinyl palmitate with 2.83 and 2.57 folds, respectively. Mechanistic studies showed that they can disrupt the lipids of intercellular orderly arrangement and reduce the content of orthorhombic lattices in the skin, making the skin loose and the barrier function decreased. Furthermore, due to the formation of chemical bonds with the skin keratin, they have a strong affinity with the skin, changing the dense secondary structure of keratin with a reduced skin barrier effect. This study provides new evidence for the potential of retinol and retinyl palmitate as novel skin penetration enhancers with high safety that possess great potential for application in the transdermal delivery of pharmaceutical and cosmetic active substances.
Robustly Injectable Tetra‐PEG Hydrogel Sealants for Annulus Fibrosus Repair
Authors: Guoke Tang, Yucai Li, Yi Liu, Lan Lin, Jielin Wang, Xing Wang, Xiaojian Ye
Journal: Advanced Healthcare Materials (2024)

Abstract Discectomy serves as the primary therapeutic approach for lumbar disc herniation, but the annular fibrosus defects after discectomy may lead to recurrence of disc herniation. Despite recent advances in bioinspired adhesives to seal the AF defect, the growing popularity of endoscopic discectomy has put forward high requirements for the tissue bioadhesives with rapid injectability, easy operation, and robust tissue adhesion in underwater environments. Herein, a rapidly in situ forming injectable tetra‐PEG bioadhesive (ISG) comprising of FDA‐approved tetra‐armed poly (ethylene glycol) amine (tetra‐PEG‐NH 2 ) and tetra‐armed poly (ethylene glycol) succinimidyl glutarate (tetra‐PEG‐SG) for the sutureless closure of AF defects, is reported. Relying on quick ammonolysis reaction between N‐hydroxysuccinimide (NHS)‐ester of tetra‐PEG‐SG polymer and amine groups of tetra‐PEG‐NH 2 polymer and tissue proteins, the uniform networks are formed within seconds with easy injection, efficient waterproofness, instant tissue adhesion, and durable compliance. The goat lumbar discectomy model was used to assess the effect of ISG hydrogels in vivo. The results reveal that the resultant ISG bioadhesive can effectively maintain the disc height, fuse with the host tissue, ameliorate IVD degeneration, and retain the initial biomechanics. Together, this study provides an efficient strategy of in situ injectable glue for the minimally invasive treatment of AF defects.
Granular Nanofiber‐Hydrogel Composite‐Programmed Regenerative Inflammation and Adipose Tissue Formation
Authors: Jiayuan Kong, Zhi‐Cheng Yao, Jessica L. Stelzel, Yueh‐Hsun Yang, Jeffrey Chen, Hexiang Feng, Collin Schmidt, Chi Zhang, Kedar Krishnan, Long Chen, Jingwen Pan, Kailei Ding, Yining Zhu, Xiaowei Li, Joshua C. Doloff, Hai‐Quan Mao, Sashank K. Reddy
Journal: Advanced Healthcare Materials (2024)

Abstract The interplay between biomaterials and host immune responses critically determines outcomes in tissue restoration. Recent studies suggest that physicochemical properties of materials can dictate pro‐regenerative versus pro‐fibrotic responses and have begun to define the key immune cell types and signals governing these divergent effects. This emerging understanding enables the engineering of regenerative biomaterials capable of functional restoration in situ. An injectable nanofiber‐hydrogel composite (NHC) microparticles are designed and constructed from cross–linked electrospun collagen nanofiber fragments surface‐bonded to the hyaluronic acid hydrogel network via covalent conjugation during the cross–linking process. The collagen nanofiber fragments, acting as the structural reinforcement component, increased the overall storage modulus of the NHC to a level comparable to native soft tissues while maintaining a sufficiently high degree of porosity of the hydrogel phase to allow host cell infiltration following subcutaneous injection of the NHC microparticles. More importantly, the NHC promoted macrophage/monocyte infiltration, migration, and spreading, sustained cell recruitment over time, and enhanced the proangiogenic effect and recruitment of PDGFRα + perivascular progenitor cells, leading to extensive adipose tissue remodeling. This study demonstrates the regenerative potential of the injectable NHC microgels as an off‐the‐shelf solution for devastating soft tissue losses.
Flower‐Like Nanosensors for Photoacoustic‐Enhanced Lysosomal Escape and Cytoplasmic Marker‐Activated Fluorescence: Enabling High‐Contrast Identification and Photothermal Ablation of Minimal Residual Disease in Breast Cancer
Authors: Lin Li, Yuxin Xing, Yuhua Chen, Kunlin Li, Yunyun Wu, Kaiyong Cai, Lu Wang, Jixi Zhang
Journal: Advanced Healthcare Materials (2024)

Abstract The clearance of minimal residual disease (MRD) after breast cancer surgery is crucial for inhibiting metastasis and recurrence. However, the most promising biomarker‐activated fluorescence imaging strategies encounter accessibility issues of the delivered sensors to cytoplasmic targets. Herein, a flower‐like composite nanosensor with photoacoustic (PA) effect‐enhanced lysosomal escape and cytoplasmic marker‐activated fluorescence is developed to address this challenge. Specifically, the incorporation of Co 2+ into the synthesis of 2D Zn 2+ ‐derived metal–organic frameworks enabled rapid dopamine polymerization and deposition. Subsequently, the composite nanoflower (FHN), characterized by an average size of ≈80 nm and petal thickness of ≈6 nm, is formed through the sealing of micropores and simultaneous cross‐linking of nanosheets. The pronounced reduction in thermal conductivity of FHN, and superposition of interpetal thermal fields under a pulsed laser (PL), lead to enhanced PA effect and membrane permeability. Thereby, nanosensors efficiently escape from lysosomes resulting in synergistic fluorescence activation by dual‐factors (ATP, miRNA‐21) and DNA probes installed on FHN. A subsequently high tumor‐to‐normal tissue signal ratio (TNR) of 17.4 lead to precise guidance of NIR irradiation for efficient MRD eradication and recurrence inhibition. This study provides a new approach for high‐contrast identification and precise ablation of MRD based on the synergistic response of endogenous and exogenous factors.
Self‐Extracting Dextran‐Based Hydrogel Microneedle Arrays with an Interpenetrating Bioelectroenzymatic Sensor for Transdermal Monitoring with Matrix Protection
Authors: Bastien Darmau, Marta Sacchi, Isabelle Texier, Andrew J. Gross
Journal: Advanced Healthcare Materials (2024)

Abstract Continuous glucose monitors have revolutionized diabetes management, yet such devices are limited by their cost, invasiveness, and stability. Microneedle (MN) arrays could offer improved comfort compared to invasive implanted or mm‐sized needle devices, but such arrays are hampered by complex fabrication processes, limited mechanical and sensor stability, and/or cytotoxicity concerns. This work demonstrates the first crosslinked hydrogel microneedle‐bioelectroenzymatic sensor arrays capable of biomarker extraction and robust transdermal continuous monitoring in artificial interstitial fluid for 10 days. The fabrication process via micromolding of dextran‐methacrylate (Dex‐MA) and dry‐state visible light crosslinking is simple and permits the robust fixation of diverse prefabricated electrodes in a single array. Dry‐state crosslinking minimized material shrinkage to enable the formation of resistant Dex‐MA microneedles with shape control and reproducibility. The polymer substitution level (9–62%) and mass content (10–30 wt%) affect the mechanical, swelling, and bioelectrocatalytic properties of the integrated sensors. Crosslinked Dex‐MA hydrogel matrices provide beneficial cytotoxicity protection and flux‐limiting membrane properties to the integrated second generation dehydrogenase‐based nanostructured buckypaper biosensor and Ag/AgCl reference electrodes. Polysaccharide‐based microneedle technology with encapsulated porous bioelectrodes promise to be a valuable alternative to more invasive devices for safer and longer‐term biomarker monitoring.
Lipid Nanoparticle‐Mediated CRISPR‐Cas13a Delivery for the Control of Bacterial Infection
Authors: Bookun Kim, Hwi Won Seo, Kyuri Lee, Dongeun Yong, Yoon Kyung Park, Yujin Lee, Solip Lee, Do‐Wan Kim, Dajeong Kim, Choong‐Min Ryu
Journal: Advanced Healthcare Materials (2024)

Abstract Lipid nanoparticles (LNPs) can assist in the delivery of nucleic acid inside animal cells, as demonstrated by their use in COVID‐19 vaccine development. However, LNPs applicable to bacteria have not been reported. Here, the screening of 511 LNPs containing random combinations of different lipid components identified two LNPs, LNP 496 and LNP 470, that efficiently delivered plasmids into Escherichia coli BW25113. Since Gram‐negative bacteria have lipid bilayers, the bacteria are pretreated with LNP‐helper that weakens the bacterial membrane. The cationic lipid DOTAP improved delivery of LNP‐encapsulated plasmid DNA when present at a molar ratio of 10–25 mol% in the LNP. LNP encapsulation of the Cas13a/gRNA expression vector controlled infection by a clinical Escherichia strain in Galleria mellonela larvae and mouse infection models when used in combination with non‐cytotoxic concentrations of polymyxin B, a bacterial membrane disruptor. Together, the results show that LNPs can be useful as a delivery platform for agents that counteract pathogenic bacterial infections.
In Vitro Modeling of Atherosclerosis Using iPSC‐Derived Blood Vessel Organoids
Authors: Dasom Kong, Jae‐Chul Ryu, Nari Shin, Seung‐Eun Lee, Nam Gyo Kim, Hee‐Yeong Kim, Min‐Ji Kim, Jungju Choi, Da‐Hyun Kim, Kyung‐Sun Kang
Journal: Advanced Healthcare Materials (2024)

Abstract As modeling of atherosclerosis requires recapitulating complex interactions with vasculature and immune cells, previous in vitro models have limitations due to their insufficient 3D vascular structures. However, induced pluripotent stem cell‐derived blood vessel organoids (BVOs) are applicable for modeling vascular diseases, containing multiple cell types, including endothelial and vascular smooth muscle cells self‐assembled into a blood vessel structure. Atherosclerotic BVOs with a microenvironment associated with atherogenesis, such as shear stress, low‐density lipoprotein, pro‐inflammatory cytokine, and monocyte co‐culture are successfully developed. In atherosclerotic BVOs, representative atherosclerotic phenotypes, including endothelial dysfunction, inflammatory responses, formation of foam cells and fibrous plaque, and moreover, calcification of the plaques are observed. To verify the drug response in this model, it is treated with clinically used lovastatin and confirm phenotype attenuation. Furthermore, the therapeutic efficacy of nano‐sized graphene oxides (NGOs) is evaluated on atherosclerosis. Due to their anti‐inflammatory effects, NGOs effectively alleviate the pathologic lesions in atherosclerotic BVOs by promoting macrophage polarization toward M2. These results suggest that atherosclerotic BVOs are advanced in vitro models suitable for drug discovery and elucidation of therapeutic mechanisms. From the perspective of precision medicine, this platform using patient‐derived BVOs can be further employed for personalized drug screening in the future.
Establishing piperacillin-tazobactam susceptibility in ceftriaxone non-susceptible Enterobacterales: comparing disk diffusion, Etest, and VITEK 2 automated MIC measurements vs. broth microdilution
Authors: Zahra N Sohani, Anthony Lieu, Reggie Bamba, Mena Patel, Mical Paul, Dafna Yahav, Emily G McDonald, Alexander Lawandi, Todd C Lee
Journal: Clinical Microbiology and Infection (2024)
Influence of gut and lung dysbiosis on lung cancer progression and their modulation as promising therapeutic targets: a comprehensive review
Authors: Rajan Thapa, Anjana Thapa Magar, Jesus Shrestha, Nisha Panth, Sobia Idrees, Tayyaba Sadaf, Saroj Bashyal, Bassma H. Elwakil, Vrashabh V. Sugandhi, Satish Rojekar, Ram Nikhate, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua, Philip M Hansbro, Keshav Raj Paudel
Journal: MedComm (2024)

Abstract Lung cancer (LC) continues to pose the highest mortality and exhibits a common prevalence among all types of cancer. The genetic interaction between human eukaryotes and microbial cells plays a vital role in orchestrating every physiological activity of the host. The dynamic crosstalk between gut and lung microbiomes and the gut–lung axis communication network has been widely accepted as promising factors influencing LC progression. The advent of the 16s rDNA sequencing technique has opened new horizons for elucidating the lung microbiome and its potential pathophysiological role in LC and other infectious lung diseases using a molecular approach. Numerous studies have reported the direct involvement of the host microbiome in lung tumorigenesis processes and their impact on current treatment strategies such as radiotherapy, chemotherapy, or immunotherapy. The genetic and metabolomic cross‐interaction, microbiome‐dependent host immune modulation, and the close association between microbiota composition and treatment outcomes strongly suggest that designing microbiome‐based treatment strategies and investigating new molecules targeting the common holobiome could offer potential alternatives to develop effective therapeutic principles for LC treatment. This review aims to highlight the interaction between the host and microbiome in LC progression and the possibility of manipulating altered microbiome ecology as therapeutic targets.
Exosomal circular RNAs in tumor microenvironment: An emphasis on signaling pathways and clinical opportunities
Authors: Junshu Li, Wencheng Zhou, Huiling Wang, Meijuan Huang, Hongxin Deng
Journal: MedComm (2024)

Exosomes can regulate the malignant progression of tumors by carrying a variety of genetic information and transmitting it to target cells. Recent studies indicate that exosomal circular RNAs (circRNAs) regulate multiple biological processes in carcinogenesis, such as tumor growth, metastasis, epithelial-mesenchymal transition, drug resistance, autophagy, metabolism, angiogenesis, and immune escape. In the tumor microenvironment (TME), exosomal circRNAs can be transferred among tumor cells, endothelial cells, cancer-associated fibroblasts, immune cells, and microbiota, affecting tumor initiation and progression. Due to the high stability and widespread presence of exosomal circRNAs, they hold promise as biomarkers for tumor diagnosis and prognosis prediction in blood and urine. In addition, designing nanoparticles targeting exosomal circRNAs and utilizing exosomal circRNAs derived from immune cells or stem cells provide new strategies for cancer therapy. In this review, we examined the crucial role of exosomal circRNAs in regulating tumor-related signaling pathways and summarized the transmission of exosomal circRNAs between various types of cells and their impact on the TME. Finally, our review highlights the potential of exosomal circRNAs as diagnostic and prognostic prediction biomarkers, as well as suggesting new strategies for clinical therapy.
The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
Authors: Jace Jones-Tabah, Kathy He, Nathan Karpilovsky, Konstantin Senkevich, Ghislaine Deyab, Isabella Pietrantonio, Thomas Goiran, Yuting Cousineau, Daria Nikanorova, Taylor Goldsmith, Esther Del Cid Pellitero, Carol X-Q Chen, Wen Luo, Zhipeng You, Narges Abdian, Jamil Ahmad, Jennifer A Ruskey, Farnaz Asayesh, Dan Spiegelman, Stanley Fahn, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Lior Greenbaum, Sharon Hassin-Baer, Roy N Alcalay, Austen Milnerwood, Thomas M Durcan, Ziv Gan-Or, Edward A Fon
Journal: Molecular Neurodegeneration (2024)
Probiotic significance of <i>Lactobacillus</i> strains: a comprehensive review on health impacts, research gaps, and future prospects
Authors: Abdul Bari Shah, Aizhamal Baiseitova, Muhammad Zahoor, Ishaq Ahmad, Muhammad Ikram, Allah Bakhsh, Murad Ali Shah, Imdad Ali, Muhammad Idress, Riaz Ullah, Fahd A. Nasr, Mohammed Al-Zharani
Journal: Gut Microbes (2024)

A rising corpus of research has shown the beneficial effects of probiotic