LABORATORY AND CLINICAL PHARMACODYNAMICS: OBSERVATIONS ON WIN 8778, WIN 12,512-2, AND WIN 13,596-2, AND AN APPROACH TO STUDYING THESE AND SIMILAR ANTIHYPERTENSIVE AGENTS
Authors: R V FORD, B J ESTES, W M FRASER, C A HANDLEY, J H MOYER
Journal: Annals of Internal Medicine (1957)

Article1 March 1957LABORATORY AND CLINICAL PHARMACODYNAMICS: OBSERVATIONS ON WIN 8778, WIN 12,512-2, AND WIN 13,596-2, AND AN APPROACH TO STUDYING THESE AND SIMILAR ANTIHYPERTENSIVE AGENTSRALPH V. FORD, M.D., BOBBY J. ESTES, M.D., WILLIAM M. FRASER, M.D., CARROLL A. HANDLEY, Ph.D., JOHN H. MOYER, M.D.RALPH V. FORD, M.D.Search for more papers by this author, BOBBY J. ESTES, M.D.Search for more papers by this author, WILLIAM M. FRASER, M.D.Search for more papers by this author, CARROLL A. HANDLEY, Ph.D.Search for more papers by this author, JOHN H. MOYER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-3-546 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONBecause of the growing number of new agents available for the treatment of hypertensive diseases, the need for simple, efficient and accurate technics for screening these compounds has arisen. The technics should also provide the criteria by which the clinician can determine the efficacy of new antihypertensive agents. We feel that at least three criteria should be fulfilled by any new agent that is to be used for the treatment of hypertension; these are: 1) the drug must be potent in the reduction of abnormally elevated blood pressures; 2) gastrointestinal absorption must be adequate and should be constant so...Bibliography1. FordMadisonMoyerDennis RVJCJHEW: Pharmacology of mecamylamine, Am. J. M. Sc. 232 (2): 129, 1956. CrossrefMedlineGoogle Scholar2. MoyerHandley JHCA: Renal and cardiovascular hemodynamic response to ganglionic blockade with Pendiomid and a comparison with hexamethonium and Arfonad, J. Pharmacol. and Exper. Therap. 113: 383, 1954. Google Scholar3. Moyer JH: Personal observation. Google Scholar4. MinatoyaLuduena HFP: A pharmacological study of a new orally active adrenolytic, 9-(2-chlorethyl) ethylaminomethyl anthracene hydrochloride, with observations on its hypotensive activity in the renal hypertensive rat, Arch. internat. de pharmacodyn. et de theráp., in press. Google Scholar5. LapeFordHoppe HDE: Observations on the ganglionic blocking properties of a series of bisquaternary tropane derivatives, J. Pharmacol. and Exper. Therap., in press. Google Scholar6. MinatoyaLapeHoppe HHEJO, of the Sterling-Winthrop Research Institute: Communications. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Houston, Texas*Received for publication May 14, 1956.From the Departments of Medicine and Pharmacology, Baylor University College of Medicine, and the Medical Service of the Veterans Administration Hospital, Houston, Texas.Requests for reprints should be addressed to Ralph V. Ford, M.D., Veterans Administration Hospital, 2002 Holcombe Boulevard, Houston 31, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEvaluation of antihypertensive effects of S.9-390 (2-(o-chlorobenzyl) imidazoline hydrochloride) 1 March 1957Volume 46, Issue 3Page: 546-567KeywordsDrugsElectrocardiographyExcretionHospital medicineHypertensionMedical servicesPharmacodynamicsPharmacologyResearch laboratoriesTachycardia ePublished: 1 December 2008 Issue Published: 1 March 1957 PDF downloadLoading ...