tbuckley/cabot-search huggingface dataset:
Abstract 16266: Lifetime Clinical History of Syncope is Associated with Future Pulseless Electrical Activity vs. Ventricular Fibrillation
Authors: Carmen Teodorescu, Kyndaron Reinier, Celia Dervan, Audrey Uy-Evanado, Mershed Samara, Harpriya Chugh, Ronald Mariani, Karen Gunson, Jonathan Jui, Sumeet S Chugh
Journal: Circulation (2010)

Introduction: There has been a significant and unexplained rise in prevalence of sudden cardiac arrest (SCA) cases presenting as pulseless electrical activity (PEA), with corresponding decrease in ventricular fibrillation (VF) rates. Given significantly lower survival from PEA vs. VF, we comprehensively investigated PEA determinants by incorporating first responder data with lifetime clinical history information. Hypothesis: We hypothesized that subjects manifesting with PEA have distinctive lifetime clinical characteristics from VF. Methods: In the Northwest US (population approximately one million), cases of out of hospital SCA that underwent attempted resuscitation were identified prospectively (2002 – 2007). Those presenting with PEA vs. VF were compared using chi-square tests and t- tests, as well as logistic regression. Results: A total of 1277cases age ≥18 years underwent resuscitation by first responders (mean age 65 ± 16 years, 67% male). Presenting arrhythmia was VF in 48%, PEA in 25% and asysto...
Abstract 15949: Bivalirudin Nanoparticles Enable Simultaneous Detection and Potent Inhibition of Acute Clotting
Authors: Jacob W Myerson, Li He, Gregory M Lanza, Douglas M Tollefsen, Samuel A Wickline
Journal: Circulation (2011)

Optimization of antithrombotics for emergency treatment of acute arterial or venous occlusions remains a significant research challenge. In recent work, a thrombin-inhibiting perfluorocarbon nanopa...
Cost utility of drugs for multiple sclerosis
Authors: J. Bryant
Journal: BMJ (2000)

Editor—We were disappointed that Forbes et al's population based cost utility study of interferon beta-1b in secondary progressive multiple sclerosis was not placed in the context of a systematic review of relevant published work.1 We recently completed such a review of the effectiveness, costs, and utility of a range of disease modifying drugs in multiple sclerosis for the health technology assessment programme. As part of this, we searched various electronic databases for published studies of the cost utility of interferon beta in multiple sclerosis: Cochrane Database of Systematic Reviews, Cochrane Controlled Trials Register, Database of Abstracts of Reviews of Effectiveness and NHS Economic Evaluations Database, Medline (Silverplatter), PubMed, Embase, and National Research Register (for the period 1980 to July 1999 and limited to English language studies). In addition, we contacted experts in the field.

In addition to Forbes et al's study, we identified three further studies: one of beta interferons (1a and 1b) in both relapsing-remitting and secondary progressive sclerosis2 and two further studies of interferon in relapsing-remitting multiple sclerosis.3,4

The table shows a summary of the results of the review. The studies in secondary progressive multiple sclerosis are based on the same trial (n=718) but use different cost utility methodologies. Forbes et al's conclusion that the cost per quality adjusted life year (QALY) was very high (£1 024 667) owing to the high drug cost and modest clinical effect concurs with the previous study's estimate of £874 600 per QALY. The studies in relapsing-remitting multiple sclerosis also use the results of the existing randomised controlled trials in conjunction with various sources of cost data, quality of life measures, and different degrees of decision analytic modelling. Results show that the cost per QALY per relapse avoided is high in all studies. 

These cost utility studies were critically appraised by using standard criteria for decision analysis and economic evaluations. Although all used explicit and sensible processes to identify, select, and combine the evidence into probabilities, and to obtain utilities and costs, with uncertainties being addressed by sensitivity analyses, none of them provide a full economic comparison of all possible healthcare strategies. The conclusion of Forbes et al that “far more benefit would be obtained from directing funds into improved supportive care,” though plausible, is not supported by the evidence presented. Further economic evaluations of a wider range of possible interventions, such as improved supportive care, are needed so that limited resources can be used effectively.
Antitumor Effect of CPT-11, a Camptothecin Derivative, on Human Testicular Tumor Xenografts in Nude Mice
Authors: Tsuneharu Miki, Masumi Sawada, Norio Nonomura, Yasauyuki Kojima, Akihiko Okuyama, Osamu Maeda, Shigeru Saiki, Toshihiko Kotake
Journal: European Urology (1997)
Media: Shell shock patients: from cowards to victims
Authors: D. Summerfield
Journal: BMJ (1998)

In 1980 I was a rural government medical officer in southeastern Zimbabwe when the civil war ended and Robert Mugabe's guerrillas could show themselves and seek treatment. One of these lay unmoving but alert in his soiled bedclothes day after day on my ward, without wounds or obvious pathology. As my concern about an atypical encephalopathy subsided, I came to see him as a case of some sort of combat stress and eventually talked him back into life.

An admirable three part television series on shell shock started this week with the first world war ( Shell Shock , Channel 4, Sundays 8 00 pm). In fact, a better place might have been the American civil war, where military doctors were perplexed that men could die not just of wounds or disease but also of what they called “nostalgia”—a contagious condition associated with morbid homesickness. “Nostalgia” became an epidemic as the war dragged on, accounting for more cases than dysentery.

During the first world war, there were 13 …
Abstract 4037: Predictors of Elevated Troponin T in an Apparently Healthy Older Population: The Rancho Bernardo Study
Authors: Lori B Daniels, Gail A Laughlin, Paul Clopton, Alan S Maisel, Elizabeth Barrett-Connor
Journal: Circulation (2006)

Background: Minimally elevated levels of cardiac troponin T (cTnT), a marker of cardiac myocyte injury, have been found in small subsets of the general population, but the cause and significance of...
SUCCESSFUL TREATMENT OF GOUT
Authors: Elmer C. Bartels
Journal: Annals of Internal Medicine (1943)

Article1 January 1943SUCCESSFUL TREATMENT OF GOUTELMER C. BARTELS, M.D., F.A.C.P.ELMER C. BARTELS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-1-21 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGout has received widespread publicity during the last 10 years, with most writers giving attention to all the various phases of the disease except the prevention of recurring attacks. We have in reality reached a point in the therapy of gout similar to that in diabetes if investigators in that field had continued to give their attention to the treatment of coma and not to its prevention. Significant is the fact that leading students of gout are at present at odds on the vital question as to whether the recurring attacks of gout can be prevented. Can the treatment be...Bibliography1. BAUERKLEMPERER WF: Gout. In: Diseases of metabolism, edited by G. G. DUNCAN, 1942, W. B. Saunders Company, Philadelphia, Chapter xii, pp. 609-654. Google Scholar2. HENCH PS: Chronic arthritis; chronic infectious arthritis, chronic senescent arthritis, gout. In: Modern medical therapy in general practice, 1940, Williams and Wilkins, Baltimore, pp. 3298-3397. Google Scholar3. LOCKIEHUBBARD LMRS: Gout; changes in symptoms and purine metabolism produced by high fat diets in four gouty patients, Jr. Am. Med. Assoc., 1935, civ, 2072. CrossrefGoogle Scholar4. LENNOX WG: A study of the retention of uric acid during fasting, Jr. Biol. Chem., 1935, lxvi, 521. Google Scholar5. ADLERSBERGELLENBERG DM: Effect of carbohydrate and fat in the diet on uric acid excretion, Jr. Biol. Chem., 1939, cxxviii, 379. CrossrefGoogle Scholar6. BARTELS EC: The treatment of gout with a low fat, high carbohydrate diet. Preliminary report, New England Jr. Med., 1939, ccxx, 583. CrossrefGoogle Scholar7. GRAHAM G: The treatment of gout, Proc. Roy. Soc. Med., 1927, xx, 1. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read at the St. Paul meeting of the American College of Physicians April 24, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCHANGES OF JAPANESE RAILWAY BALLAST QUALITY STANDARDSRheumatology Practice at Mayo Clinic: The First 40 Years–1920 to 1960Efficacy of Colchicine Prophylaxis in Gout Prevention of Recurrent Gouty Arthritis Over a Mean Period of Five Years in 208 Gouty SubjectsTS'AI FAN YÜ, M.D., ALEXANDER B. GUTMAN, M.D., F.A.C.P.Die GichtCurrent principles of management in goutTREATMENT OF GOUTSUNSHINE AND TUBERCULOSIS IN CATTLE 1 January 1943Volume 18, Issue 1Page: 21-28KeywordsComaDiabetes preventionGout ePublished: 1 December 2008 Issue Published: 1 January 1943 PDF downloadLoading ...
Immunologic Induction of Malignant Lymphoma: Identification of Donor and Host Tumors in the Graft-Versus-Host Model 2
Authors: Ernst Gleichmann, Helga Gleichmann, Robert S. Schwartz, Anita Weinblatt, Martine Y. K. Armstrong
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Immunologic Induction of Malignant Lymphoma: Identification of Donor and Host Tumors in the Graft-Versus-Host Model Get access Ernst Gleichmann, Ernst Gleichmann Search for other works by this author on: Oxford Academic PubMed Google Scholar Helga Gleichmann, Helga Gleichmann Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert S. Schwartz, Robert S. Schwartz Search for other works by this author on: Oxford Academic PubMed Google Scholar Anita Weinblatt, Anita Weinblatt Search for other works by this author on: Oxford Academic PubMed Google Scholar Martine Y. K. Armstrong Martine Y. K. Armstrong Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 54, Issue 1, January 1975, Pages 107–116, https://doi.org/10.1093/jnci/54.1.107 Published: 01 January 1975 Article history Received: 29 May 1974 Accepted: 12 September 1974 Published: 01 January 1975
Strategies to reduce curative antibiotic therapy in intensive care units (adult and paediatric)
Authors: Cédric Bretonnière, Marc Leone, Christophe Milési, Bernard Allaouchiche, Laurence Armand-Lefevre, Olivier Baldesi, Lila Bouadma, Dominique Decré, Samy Figueiredo, Rémy Gauzit, Benoît Guery, Nicolas Joram, Boris Jung, Sigismond Lasocki, Alain Lepape, Fabrice Lesage, Olivier Pajot, François Philippart, Bertrand Souweine, Pierre Tattevin, Jean-François Timsit, Renaud Vialet, Jean Ralph Zahar, Benoît Misset, Jean-Pierre Bedos
Journal: Intensive Care Medicine (2015)
Factors predicting complete surgical resection after induction chemotherapy in patients with initially unresectable non-small cell lung cancer (NSCLC) treated in a randomised trial
Authors: Philippe Lothaire, Jean-Jacques Lafitte, Vicente Giner, Thierry Berghmans, Peggy Wackenier, Marianne Paesmans, Paul Mommen, Paul Van Houtte, Vincent Ninane, Jean-Paul Sculier
Journal: European Respiratory Journal (2003)
Patent Foramen Ovale and Cryptogenic Stroke
Authors: Bernhard Meier, Peter Jüni
Journal: New England Journal of Medicine (2013)

and the corresponding editorial by Messé and Kent 3 (March 21 issue) illustrate a major problem in clinical trials.When it is not obvious which of two therapies is better, sufficient numbers of events are essential to reach a conclusion.Performing a prospective, randomized trial is not enough.In the PC Trial (Clinical Trial Comparing Percutaneous Closure of Patent Foramen Ovale [PFO] Using the Amplatzer PFO Occluder with Medical Treatment in Patients with Cryptogenic Embolism), 1 primary-end-point events occurred in only 18 patients in the two groups, even though 414 patients and 29 international sites participated.Any difference may have been due to chance.The investigators in the RESPECT (Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment) 2 trial enrolled 980 patients at 69 sites, yet there were only 25 primaryend-point events.The proper conclusion of these studies, even though they were well designed and carefully performed, is that too few events were observed to draw any conclusion.When the Early Breast Cancer Trialists' Collaborative Group 4 performed the first metaanalysis of the value of adjuvant tamoxifen -one of the most effective medications in our pharmacopoeia -for breast cancer, only 6 of 42 randomized trials had shown significant benefit.Only trials with many patients and many events are likely to overcome the play of chance.
Abstract 433: Plasma and Urinary Aldosterone Levels in Rats with Non-Insulin Dependent Diabetes Mellitus - Association with Myocardial Fibrosis
Authors: Sabine Fredersdorf, Dierk Endemann, Christoph Birner, Markus Resch, Gunter A Riegger, Andreas Luchner, Joachim Weil
Journal: Circulation (2006)

Initial stages of diabetic cardiomyopathy in hyperinsulinemic rats are characterized by cardiomyocyte hypertrophy, enhanced cardiac contractility and marked perivascular fibrosis. Aldosterone is kn...
Abstract 17234: The EFFICAS Studies: Reducing Low Force-Time Integral (FTI) Radiofrequency Applications Improves Procedural Efficacy During Pulmonary Vein Isolation
Authors: Erik Wissner, Jan Petru, Andreas Metzner, Petr Peichel, Mary Soranno, Hendrik Lambert, Josef Kautzner, Petr Neuzil, Karl-Heinz Kuck
Journal: Circulation (2011)

Objectives Results of the EFFICAS I study illustrate that in patients with paroxysmal atrial fibrillation (PAF) undergoing pulmonary vein isolation (PVI), ablation using low Force-Time Integral (FTI &lt;400 gs) predicts early gap formation. The EFFICAS II multicenter study prospectively evaluated whether limiting the number of low FTI ablations during PVI improves procedural efficacy. Methods Patients with PAF underwent PVI using an ablation catheter with an integrated Contact Force (CF) sensor (TactiCath®, Endosense, Switzerland). Operators were requested to start ablation when CF was ≥ 10 g and to avoid ablations with FTI &lt; 400 gs, thereby demonstrating good catheter stability. Procedure duration, RF ablation time, number of ablations for PVI and fluoroscopy time were compared between EFFICAS I and EFFICAS II. Results Five operators in 3 centers treated 30 patients in EFFICAS I and 34 patients in EFFICAS II. All PVs (100%) were isolated at the end of the procedure. In EFFICAS I, 42% of 2060 ablations were performed with an FTI &lt; 400 gs, compared to 18% of 1860 ablations applied in EFFICAS II. There was a statistically significant reduction in RF ablation time, number of ablations, and fluoroscopy time in EFFICAS II as compared to EFFICAS I (table). Conclusions Reducing the number of radiofrequency ablations with an FTI &lt; 400 gs increases the efficacy of ablation during PVI. Whether more effective ablation will increase safety and improve outcome following PVI needs to be determined.
State and personality in depressed and panic patients
Authors: James Reich, Russell Noyes, Robert Hirschfeld, William Coryell, Tom O'Gorman
Journal: American Journal of Psychiatry (1987)

The authors examined 36 patients with panic disorder, 66 patients with major depression, and 124 control subjects to determine personality differences between them in the ill and the recovered states. The panic and depressed groups did not differ from each other in either state. Both recovered groups had less emotional strength and greater interpersonal dependency than the control subjects. The effect of state on personality measures appears to be similar for anxious and depressed patients. No personality measures that clearly differentiated the recovered panic and depressed patients were found.
AML1-ETO Collaborates with the TALE Homeobox Genes MEIS1 and MEIS2 in Inducing AML.
Authors: Naidu M Vegi, Josef Klappacher, Franz Oswald, Rainer Claus, Medhanie M Mulaw, Verena Thiel, Vijay P.S Rawat, Leticia Quintanilla Fend, Christoph Plass, Konstanze Döhner, Hartmut Döhner, Wolfgang Hiddemann, Michaela Feuring Buske, Christian Buske
Journal: Blood (2012)
Abstract 2490: Non-uniformity of Three-dimensional Left Ventricular Relaxation Abnormalities in Hypertensive Left Ventricular Hypertrophy by Speckle Tracking Global Strain Rate Imaging
Authors: Takeshi Takamura, Kaoru Dohi, Katsuya Onishi, Naoki Fujimoto, Tairo Kurita, Shinya Kato, Norikazu Yamada, Mashio Nakamura, Naoki Isaka, Masaaki Ito
Journal: Circulation (2007)

Background: We tested the hypothesis that global strain rate imaging can quantify and stratify the severity of left ventricular (LV) relaxation abnormality in patients with left ventricular hypertrophy (LVH) ranged from normal to reduced LV systolic function independently from longitudinal (L), circumferential (C), and radial axes (R). Methods: Fifty-seven patients with hypertensive LVH and thirty age matched controls (Control, EF 65 ± 5 %) had echo-study with speckle tracking strain and strain rate imaging from (L), (C), and (R). LVH were divided into two groups; normal EF (LVH-NEF) defined as EF ≥ 55% (n = 35, EF 64 = 5 %), and systolic dysfunction (LVH-SD) defined as EF &lt; 55% (n = 22, EF 48 ± 8 %). Global peak systolic strain (PSS) and peak relaxation rate (PRR) were used as indices of global LV contraction and relaxation, respectively (Vivid 7 and EchoPAC, GE Electronic). Results: PSS was maintained in LVH-NEF but reduced in LVH-SD from all three perpendicular axes. PRR (L) was impaired in LVH-NEF and was further decreased in LVH-SD (0.95 ± 0.33* and 0.58 ± 0.24* † 1/s, *p &lt;0.05 vs. Control and † p &lt;0.05 vs. LVH-NEF, respectively)compared to Control (1.14 ± 0.30 1/s). PRR (C) was maintained in LVH-NEF but reduced in LVH-SD (1.24 ± 0.50 and 0.73 ± 0.36 1/s*, p &lt;0.05 vs. Control) compared to Control (1.30 ± 0.48 1/s). PRR (R) was impaired in both LVH-NEF and LVH-SD in the same degrees (-1.53 ± 0.60* and -1.27 ± 0.64* 1/s, p &lt;0.05 vs. Control: -2.08 ± 0.84 1/s). Conclusion: Speckle tracking strain rate imaging quantified and stratified the severity of LV relaxation abnormality in patients with LVH ranged from normal to reduced LV systolic function independently from all three perpendicular ventricular axes.
Effect of benzylpenicillin-ciprofloxacin vs. ceftriaxon-ciprofloxacin in treatment of massive pneumonia (CAP-community acquired pneumonia)
Authors: Vojislav Radosavljevic, Milica Obradovic, Natasa Petrovic
Journal: European Respiratory Journal (2011)

In the past few years a high level of massive pneumonia has been noticed. The aim of study was to compare the effect of benzylpenicilln-ciprofloxacin versus ceftriaxon-ciprofloxacin in treatment of massive pneumonia.   Material and methods:  There were 60 patients (male-34;female-26;22-68 years old) who were divided in two groups according to the therapeutical treatment. All patients had radiological image of lobar massive CAP with biochemistry verification, and port score between 70-90. The first group with thirty patients was treated with a combination of benzylpenicillin (1.6 million i.m. per day)-ciprofloxacin (500mgx2 p.o. per day) for seven days. The second group with also thirty patients was treated with a combination of ceftriaxon (2g per day)-ciprofloxacin (500mgx2) also for seven days. After the treatment we compared radiological image according to RECIST criteria.   Results:  In the first group were 14 with complete, 10 with partial, 2 with stable response and 4 with progression of disease. In the second group there were 16 with complete, 7 with partial, 4 with stable response and 3 with progression of disease. There were no deaths and no complications during the treatment. There was no statistical significance between the two groups of patients in treatment of massive pneumonia (CAP-Community acquired pneumonia) p>0.05.   Conclusion:  According to our result we can conclude that the combination of benzilpenicilin-ciprofloxacin has given good results in treatment of massive lobar pneumonia (CAP) with good safety and tolerance. Costs benefit recommends benzylpenicillin-ciprofloxacin for therapy of choice.
Abstract 17667: Local Atrophy of Parahippocampal Gyrus is Prominent in Heart Failure Patients Without Dementia
Authors: Tomomi Meguro
Journal: Circulation (2014)

Introduction: The exacerbation of heart failure (HF) induces brain damage and the cognitive impairment that attenuates the effects of treatment. The medial lateral lobe of brain, including parahippocampal gyrus, is known to reduce its volume in patients with cognitive disorder especially in Alzheimer’s disease. The magnetic resonance imaging (MRI) scans identify morphological changes in the brains of patients with HF. Therefore, the Voxel-based morphometry (VBM) of three-dimensional brain MRI may contribute to predict the potential risk of mild cognitive impairment (MCI) of patients with HF. Hypothesis: The severity of local atrophy of parahippocampal gyrus, a potential risk of MCI, is prominent in heart failure patients without dementia. Methods: Ten HF patients (age 72+/-15 years, NYHA class II, EF43+/-15 %) and 9 control (age 76+/- 8 years) were enrolled. Patients with dementia were excluded from this study. Three dimensional T1 weighted sagittal images of whole brain were taken using 1.5T MRI. Image analysis was performed to evaluate the severity of local brain atrophy of gray matter using 2mm VBM by the software based on statistical parametric mapping. The Z-score value of volume of interest (VOI) was calculated to evaluate the severity of atrophy in parahippocampal gyrus. Results: The severity of total brain atrophy was similar between HF (8.3+/-3.4%) and control (8.0+/-4.1%). However, as shown in the figure of representative cases, the Z-score value of VOI (pink circle), reflecting the severity of atrophy in parahippocampal gyrus (white arrows), was larger in HF patients group (1.4+/-0.7) in comparison with control group (0.8+/-0.4, P=0.034). The Z-score value was not correlated with age, ejection fraction, left atrial dimension, left ventricular dimensions, or BNP in HF group. Conclusions: In patients with HF, atrophy in parahippocampal gyrus was prominent in comparison with control. Patients with heart failure have potential risk of MCI and dementia.
解读《高血压防治基层实用规范》(三)
Authors: 姚崇华
Journal: BMJ (2004)

(上接2004年第1期第20页) 四、如何有效开展高血压非药物治疗? 非药物治疗是通过调整生活方式达到治疗高血压的目的,它是高血压病的辅助治疗措施,但对所有高血压患者都必不可少,尤其是患者具有早发心血管病的其他危险(如脂肪代谢紊乱或糖尿病)时就更要重视.
Abstract 12656: Does Repeat Myocardial Revascularization Benefit Outcome in Asymptomatic Patients with Ischemia on Follow-Up after Previous Revascularization?
Authors: Nael H Aldweib, Kazuaki Negishi, Rory Hachamovitch, Nina Rashedi, Wael Jaber, Thomas Marwick
Journal: Circulation (2012)