tbuckley/cabot-search huggingface dataset:
Findings of Aberrant Epidermal Growth Factor Receptor in Primary Human Malignant Gliomas
Authors: Noriaki Sugawa, A. Jonas Ekstrand, C. David James, V. Peter Collins
Journal: Neuro-Oncology (1991)

The epidermal growth factor receptor gene has been found to be amplified and rearranged in primary human malignant gliomas. Here we present the sequence across a novel splice junction of aberrant epidermal growth factor receptor transcripts in primary, human malignant gliomas. RNA was studied on Northern blots using anti-sense synthetic-oligonucleotides to different parts of the EGFR. For detailed studies, double stranded complimentry DNA was produced from total RNA by reverse transcription followed by specific PCR amplification. Unbalanced PCR was used to produce single-stranded complementary DNA templates for sequencing. Aberrant, shortened EGF-R transcripts were found in malignant gliomas. Sequencing showed that the majority of the aberrant transcripts had lost the same 801 bases, which code for a part of the extracellular domain of the the EGF-R. This transcript abnormality was found in 22 of 44 glioblastomas, 3 of 9 anaplastic gliomas, and 0 of 18 gliomas of malignancy grades I and II.
85岁以上老人的健康与疾病 虽然有病，但残疾率低
Authors: Thomas, Perls, 王翠娣
Journal: BMJ (2010)

80岁及80岁以上的人群是世界上增长最快的年龄组，从2007年7月至2008年7月，美国85岁以上的人群增长了3．5％，而总人口的增长才为0．73％。Collerton及同事对人口所做的研究（见本期第109页）显示：虽然老年人群空前增长，但许多老人明显体弱并伴有残疾，这意味着什么却所知甚少。为了弄清此情况，作者在英国泰恩河畔纽卡斯尔港市和北泰恩赛德地区进行调研，64位全科医生中有53人参与了此项研究，他们给自己所管辖的出生于1921年的老年人（终末期病人除外）发信函进行调研，
上消化道疾病基础知识（四）——幽门螺杆菌感染的治疗
Authors: 王玉珍, 夏志伟
Journal: BMJ (2003)

自我血糖监测(self monitoring of blood glucose,SMBG)是糖尿病综合治疗方法中的一个重要环节,是对糖尿病教育、饮食控制、体育锻炼、应用降糖药物疗效的评价,并指导降糖治疗方案的调整.有规律地进行SMBG有助于鼓励患者积极地参与糖尿病管理,为医生调整治疗方案提供血糖数据.基层社区医生应该正确指导糖尿病患者进行血糖监测,使血糖控制达标、延缓糖尿病慢性并发症。
Preclinical Liver Metastases: Three-Dimensional High-Frequency Ultrasound Imaging
Authors: Kevin C. Graham, Lauren A. Wirtzfeld, James C. Lacefield, Ann F. Chambers
Journal: Liver Cancer (2009)

Metastasis, the spread of a primary cancer to distant organs, continues to be the most significant cause of cancer mortality. Isolated primary tumors can often be treated surgically with a relatively high success rate. However, if the primary tumor has invaded the surrounding tissue and metastasized to secondary sites in the body, treatment options are often limited to systemic chemotherapies with much lower success rates and greater toxicity. Thus, it is imperative that a greater understanding of the biology of the metastatic process be acquired in order to achieve a significant reduction in the morbidity and mortality associated with cancer diagnosis. The process of metastasis consists of multiple biological steps governed by a wide range of molecular processes (Chambers et al., 2002). The cells in a developing primary tumor must invade the surrounding tissue and gain access to a blood or lymphatic vessel to facilitate dissemination. Once the metastatic cell has arrived at a secondary site, the cell must arrest in the vascular system, survive, undergo cell division in the new microenvironment, and eventually recruit new blood vessels to allow for continued development. Although many cells initiate this sequence of events by gaining access to the vascular system, < 1% of these cells are able to complete all of the steps to form overt metastases (Chambers et al., 2002). The multi-step nature and biological and molecular complexity of the metastatic process have necessitated that a variety of research tools be used to effectively model this process. In vitro models have allowed for a greater understanding of how tumor cells circumvent normal cell growth and survival regulations. In vitro models are essential to isolate the contribution of specific molecular pathways to the development of a metastatic cell, but fail to capture the complexity of the entire metastatic process that exists in the in vivo situation. Thus, in order to study the complete metastatic process it is necessary to develop and utilize animal models. Animal models are used to study the interactions of a tumor cell with a changing micro-environment as it progresses through the metastatic process, and are often used to evaluate novel therapeutics and treatment strategies.
Working Capacity of Normal Children Tested on Bicycle Ergometer
Authors: G R CUMMING, P M CUMMING
Journal: JAMA (1963)

Working capacity defined as that work load performed at a minute pulse rate of 170 was determined in 200 school children aged 6 to 16 and in 40 young adults. Working capacity increased gradually with age and was greater in boys than girls at all ages. The range of normal was large. Working capacities of 11- and 12-year-old Winnipeg children in kg./M./min. were 384 for boys and 300 for girls, these values being 19 and 14% below comparable studies from California and Sweden. Working capacities of Winnipeg student nurses averaged 478 kg./M./min., half the value reported for nurses from Sweden.
2型糖尿病的筛查和预防——即使准确的成本效益尚不确定，也应尽早干预
Authors: 张晓梅, 纪立农
Journal: BMJ (2008)

目前，成本效益模型已广泛用于帮助决策者和临床医师制定及选择干预策略。模型有其局限性，这很好理解——一个模型的可信性或可推广性取决于所报告的假设和数据。再者，一个成本效益模型也不能处理所有可行性、可接受性或可承受性问题，而这些对于执行决策至关重要。然而，决策分析模型常常有助于确定可能影响成本效益的关键因素，从而使决策者更好地理解其他不确定因素的重要性，面对不确定性能作出较为合理的决策。
Prognostic Value of CT Angiography for Major Adverse Cardiac Events in Patients With Acute Chest Pain From the Emergency Department
Authors: Christopher L. Schlett, Dahlia Banerji, Emily Siegel, Fabian Bamberg, Sam J. Lehman, Maros Ferencik, Thomas J. Brady, John T. Nagurney, Udo Hoffmann, Quynh A. Truong
Journal: JACC. Cardiovascular imaging (2011)
Abstract 18951: Is Sigmoid Septum an Age Related Phenomenon or a Variant of Hypertrophic Cardiomyopathy?
Authors: Isuru Ranasinghe, Chaitu Cheruvu, John Yiannikas
Journal: Circulation (2010)

Background: It is uncertain if sigmoid septum (SS) is a variant of hypertrophic cardiomyopathy (HCM) particularly in the setting of SS with left ventricular outflow tract obstruction (LVOTO) when i...
OSU-T315, An Integrin-Linked Kinase (ILK) Inhibitor, Induces Apoptosis By Targeting B Cell Receptor and CD49d Mediated AKT/ERK Activation In Chronic Lymphocytic Leukemia Cells
Authors: Ta-Ming Liu, YongHua Ling, Mitch A. Phelps, Jennifer A. Woyach, Erin K Hertlein, William H. Towns, Jessica MacMurray, Santosh B. Salunke, Ching-Shih Chen, John C. Byrd, Amy J. Johnson
Journal: Blood (2013)
Anger and fear
Authors: Hossain B. Danesh
Journal: American Journal of Psychiatry (1977)

The author proposes that fear and anger are innate defensive mechanisms mobilized by preceived threats to the individual. Both mechanisms are accompanied by anxiety and an urge to escape or attack. The individual's lifestyle, which is the result of interaction between his innate qualities and life experiences, determines whether he will attempt to deal with threats, his fear and/or anger, and the resulting anxiety in an objective or pathological manner. This formulation underscores the need to learn methods of coping with anger and fear from early childhood, so that they do not develop into pathological behavior patterns.
Trabectedin in third line breast cancer: A multicenter, randomized, phase II study comparing two administration regimens
Authors: J. S. Gurtler, L. Goldstein, S. Delprete, S. Tjulandin, V. Semiglazov, L. Sternas, B. Michiels, E. Gilles
Journal: Journal of Clinical Oncology (2005)

625 Background: Trabectedin (Yondelis, ET-743) is a marine-derived compound binding the minor groove of DNA that is active at nM concentrations. Trabectedin is thought to act through the transcription-coupled nucleotide excision repair system. In clinical trials Trabectedin has demonstrated activity in soft tissue sarcoma, ovarian and breast cancer. Methods: Patients (pts) with advanced breast cancer exposed to both anthracyclines and taxanes and at most two prior lines of chemotherapy, were randomized in a multicenter Phase II study, to receive Trabectedin on either, 0.58 mg/m2 weekly/three out of four weeks (weekly Arm) or 1.3mg/m2 every 3 weeks schedule (q3weeks Arm). Pts were premedicated with Dexamethasone. Results: Both Arms were well balanced for performance status and prior anticancer therapy (median=4). Pts (weekly vs. q3weeks) received a median of 2 vs 4 cycles, respectively; RDI delivered was 76 vs. 81%. Efficacy: Responses were 1/27 vs 3/25, including one CR, for a RR of 3.75 vs 12%. TTP (hazard ratio =1.5/ p-value=0.18) and OS, showed a superiority trend for the q3weekly schedule. Safety: 201 cycles were delivered. Most notable grade 3/4 lab abnormalities (weekly vs q3weeks) were neutropenia, 0% vs 9% and ALT, 8% vs 18%. However, when the drug was discontinued because of an adverse event (19% in the weekly Arm, compared to only 4% in the q3weeks Arm) this was always due to liver related lab abnormalities. Six cases of mild CPK elevations were observed, all on the weekly Arm. Asthenia and nausea/vomiting were equally common on both Arms (66% vs 54% and 55% vs 45%). Conclusion: Activity was noted in both Arms of this heavily pretreated patient population. A consistent trend towards superior efficacy was noted in the q3weekly Arm. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Johnson & Johnson Pharmaceutical Research and Development Johnson & Johnson Pharmaceutical Research and Development
Abstract 17411: Exploring the Interference Between Wireless Capsule Endoscopy and Cardiac Device Radiofrequency.
Authors: Peter S Fleming, Victoria Lossen, Janine Brown, Stacey Neuman, James Kippola, Ryan Collins, William D Verhoef, Brenda Smith, David Johnson, John Herre
Journal: Circulation (2010)

Methods: In-vitro experiments were conducted in a specially-designed saline bath simulating the distances expected during concomitant use of these devices. Current generation dual-chamber PMs and I...
Development of DNA-affinic aminoanthraquinones with alkylating potential that exhibit potent cytotoxicity against resistant ovarian carcinoma cell lines
Authors: Klaus Pors, Steve Shnyder, Mike C. Bibby, John A. Hartley, Mire Zloh, Mark Searcey, Laurence H. Patterson
Journal: Cancer Research (2006)

1115   A novel series of chloroalkylaminoanthraquinones with alkylating potential, modelled on the non-symmetrical configuration of Alchemix, has been developed and is reported. The synthetic route to the target compounds involved preparation of heterocyclic (piperidinyl or pyrrolidinyl) alkylamino sidechains, by alkylating the heterocyclic moiety with halide-acetonitrile followed by reduction of the nitrile to the respective primary amine (R-CH 2 CH 2 -NH 2 , R = heterocyclic). The heterocyclic alkylamino sidechains were then substituted onto anthraquinone chromophores to give a series of 1,4-disubstituted hydroxylalkylaminoanthraquinones. Conversion of the hydroxylated aminoanthraquinones to their chlorinated derivatives involved treatment with Ph 3 P-CCl 4  complex. A novel route for the development of chloroalkylaminoanthraquinones was also devised in order to obtain target compounds containing secondary chlorides. This route comprised a 5-step procedure which involved (1) Boc-protection of hydroxylated heterocyclic alkylamino sidechains, (2) mesylation of the hydroxyl group, (3) conversion to the chloride with tetra- n -butylammonium chloride, (4) deprotection of the Boc group and (5) substitution onto either 1,4-difluoro-5,8-dihydroxyanthraquinone or 1-{2-[ N,N -(dimethyl)amino]ethylamino]-4-fluoro-5,8-dihydroxy-anthraquinone. The novel chloroalkylaminoanthraquinones were shown to alkylate guanine residues of linearised pBR322 (1-20 μM) by using a DNA  Taq -polymerase based footprinting assay, which was in good correlation to DNA-drug modelling studies. Two symmetrical chloroalkylaminoanthraquinones, 1,4-bis-{2-[(2-chloroethyl)-piperidinyl]-ethylamino}-5,8-dihydroxy-anthracene-9,10-dione KP190M and 1,4-bis-{2-[(2-chloroethyl)-pyrrolidinyl]-ethylamino}-5,8-dihydroxyanthracene-9,10-dione KP177M were found to interstrand crosslink pBR322 DNA at nM concentration by assessment in an  in vitro  gel based assay. Selected chloroalkylaminoanthraquinones and their non-covalent binding hydroxylated precursor anthraquinones were found to unwind supercoiled pBR322 DNA. The chloroalkylaminoanthraquinones with alkylating capacity were shown to be nM cytotoxic (IC 50  values: 9-428 nM) in the A2780 ovarian cancer cell line. Significantly, the chloroalkylaminoanthraquinones remained cytotoxic in doxorubicin (2780AD) and cisplatin (2780CP) resistant cell lines.
Abstract 3162: Physical Activity and the Risk of Incident Atrial Fibrillation in Women
Authors: Brendan M Everett, David Conen, Julie E Buring, I-Min Lee, Christine M Albert
Journal: Circulation (2008)

Physical activity (PA) is well known to reduce the risk of cardiovascular disease. We hypothesized that regular PA, possibly acting through reductions in blood pressure and body mass index (BMI), w...
Simultaneous administration of control-released basic fibroblast growth factor enhances the efficacy of skeletal myoblast transplantation by increasing vascular density and graft volume
Authors: K Tambara, GU Premaratne, Y Sakakibara, G Sakaguchi, H Nakajima, X Lin, N Kanemitsu, M Yamomoto, M Ozeki, Y Tabata
Journal: Circulation (2003)
Abstract A20: Molecular dissection of pancreatic cancer invasion and metastasis
Authors: Shin-Heng Chiou, Monte Winslow
Journal: Cancer Research (2015)

Abstract Pancreatic ductal adenocarcinoma (PDAC) is an almost uniformly fatal malignancy of the exocrine pancreas. Although several factors contribute to the poor prognosis of this disease, the ability of cancer cells to disseminate and establish inoperable metastases before diagnosis is a major impediment to successful therapy. Unfortunately, strategies that enable efficacious treatment or early detection of the disease do not exist, highlighting an urgent need for a critical understanding of PDAC progression and dissemination. To identify novel molecular mechanisms that drive metastasis, we compared the transcriptomes of “invasive” and “non-invasive” cancer cells isolated from tumors that are derived from a previously described autochthonous PDAC model (KrasLSL-G12D;p53LSL-R172H;Pdx1-cre or KPC mice). This mouse model was chosen because it recapitulates many aspects of the human disease, including cellular heterogeneity, abundant stromal responses, and great propensity for metastasis. To isolate pure PDAC cells, we first excluded the infiltrating, non-cancer cells by incorporating a Cre-reporter allele (R26LSL-Tomato) into the KPC mice. Our strategy to distinguish “invasive” from “non-invasive” cancer cells was based on our previous observations that the high mobility group AT-hook 2 protein (Hmga2), which is otherwise not expressed in most of adult tissues, is specifically expressed in cancer cells with mesenchymal phenotype. To label cancer cells that express Hmga2, we generated a conditional Hmga2-GFP reporter mouse. When a single Hmga2GFP allele is present in the KPC;R26LSL-Tom mice, we were able to sort both Hmga2-positive (GFP+Tomato+) and Hmga2–negative (GFP-Tomato+) cancer cells. Intravenous transplantations indicated that the GFP+ cancer cells have significantly higher metastatic ability. Furthermore, transcriptomic profiling of the sorted, un-passaged cells through RNA-Seq indicated that Hif1α activity is highly enriched in the invasive GFP+ cancer cells. Consistent with the RNA-Seq data, the expression of the Hif1α target Glut1 correlates with Hmga2 under immunohistochemical staining. We hypothesized that during PDAC progression, hypoxia induces the both up- and down-regulation of a set of genes, including both Hif1α-dependent and –independent ones, that are necessary to drive cancer metastasis. Future experiments will functionally interrogate, both in vitro and in vivo, the candidate genes selected based on presence of human orthologs, cross-examination with co-purified myofibroblast transcriptomic profiles, fold change, and novelty. Our study will help identify important molecular mechanisms that drive PDAC metastasis. Citation Format: Shin-Heng Chiou, Monte Winslow. Molecular dissection of pancreatic cancer invasion and metastasis. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2015;75(13 Suppl):Abstract nr A20.
银行家、投机商、赌徒？
Authors: 顾佳
Journal: BMJ (2011)

当我还是一个跃跃欲试的无名小卒时，我被呼作赌徒。后来，我主刀的手术越来越大，越来越多，我也就成了投机商。现在，我的业务范围仍在扩大，我摇身变成了银行家。可事实上，我始终都在做着同一件事情。
Abstract 724: The Addition of Coronary Artery Calcium Scoring (CAC) to Myocardial Perfusion Imaging (MPI) Improves Diagnostic Accuracy in the Detection of Obstructive CAD: Results of a Prospective Multicenter Trial
Authors: Gregory S Thomas, Matthew J Budoff, Jennifer H Mieres, Ella A Kazerooni, Leslee J Shaw
Journal: Circulation (2008)

Background: The PICTURE Trial evaluated the accuracy of 64-CT coronary angiography (CCTA) &amp; MPI to invasive coronary angiography (ICA) for the detection of obstructive CAD. CCTA included an evaluation of Coronary Artery Calcium. The objective of this substudy was to evaluate the combination of measures of ischemia &amp; atherosclerosis, with MPI &amp; CAC respectively. Methods: 230 patients [52% male, 56.9 yrs] referred for MPI for chest pain were prospectively enrolled at 12 sites. 22% of patients underwent ICA for either abnormal MPI or coronary CCTA. The efficacy was assessed on a per-patient basis. Results: Of the 47 patients prospectively enrolled that underwent ICA, the prevalence of a &gt;50% stenosis by ICA was 47% (22/47). Mean CAC for all patients was 434 +/−926. The frequency of obstructive CAD based on MPI &amp; CAC are shown in the Figure . The odds (95% CI) for obstructive CAD is elevated 12.73-fold (2.43– 66.55) for ≥5% myocardium with stress defects (p&lt;0.0001). Adding stress EF to perfusion results in a diagnostic sensitivity &amp; specificity of 76.0% &amp; 90.9% (p&lt;0.0001). For CAC ≥100 alone, the diagnostic sensitivity &amp; specificity is 76% &amp; 72.7% (p=0.001). Adding a CAC score &gt;100 to perfusion + EF increases the odds of obstructive CAD by 2.5-fold (1.31– 4.77, p=0.006). In patients with &lt;5% defects, the addition of a CAC score of &gt;100 increased the odds by 4.8-fold (0.95–24.14, p=0.057). ROC analysis revealed the % myocardium with stress defects categorized obstructive CAD with an area of 0.76 (95% CI=0.62– 0.90, p=0.002). Adding CAC improved the area to 0.85 (95% CI=0.74–0.96, p&lt;0.0001). Conclusion: The addition of CAC to MPI improves diagnostic accuracy in the detection of obstructive CAD. Prevalence of ≥50% Obstructive CAD by MPI &amp; CAC
The studies about doxorubicin-loaded p(N-isopropyl-acrylamide-co-butyl methylacrylate) temperature-sensitive nanogel dispersions on the application in TACE therapies for rabbit VX2 liver tumor
Authors: Kun Qian, Yingying Ma, Jiangshan Wan, Shinan Geng, Han Li, Qianwen Fu, Xiaole Peng, Xuefeng Kan, Guofeng Zhou, Wei Liu, Bin Xiong, Yanbing Zhao, Chuansheng Zheng, Xiangliang Yang, HuiBi Xu
Journal: Journal of Controlled Release (2015)
Ten-year analysis of the NSABP B-50 study.
Authors: P J Goodwin, N F Boyd, R S Bush
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.11.1718 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3534156 Ten-year analysis of the NSABP B-50 study. P J GoodwinxP J GoodwinSearch for articles by this author , N F BoydxN F BoydSearch for articles by this author , R S BushxR S BushSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.11.1718 PDF "Ten-year analysis of the NSABP B-50 study.." Journal of Clinical Oncology, 4(11), pp. 1718–1721© 1986 by American Society of Clinical Oncology
Abstract 2209: Impaired Diastolic Filling During Exercise Negatively Impacts Exercise Capacity in Children Who Have Undergone the Fontan Operation
Authors: William L Border, Wayne A Mays, John T Hambrook, Peace C Madueme, Sandy K Knecht, Yvette M Gerdes, Vicky Moore, Sandra A Witt, Betty J Glascock, Erik C Michelfelder, Timothy K Knilans, Thomas R Kimball
Journal: Circulation (2007)

Background: Increased cardiac output during exercise relies on synergy between forward pumping of the heart and a peripheral pump, comprised of skeletal muscle function and arteriolar dilation, which augments venous return. The critical component of this two-pump system is the maintenance of normal filling pressures, by enhancing diastolic filling. We hypothesized that children with normal systemic ventricular function, who have undergone the Fontan operation, have impaired diastolic filling during exercise which may negatively impact exercise capacity. Methods: Stress echocardiography was performed during upright cycle ergometry in a group of Fontan patients with normal systolic function (n=14) and a group of normal controls (n=17). Echo parameters obtained at each stage of exercise included early myocardial velocity at the systemic atrioventricular valve lateral annulus (Em), continuous wave Doppler velocity of ventricular inflow (E), calculation of the E/Em ratio (index of ventricular filling pressures), diastolic filling time (DFT), stroke volume (SV) and cardiac output (Q). Heart rate (HR) and maximal aerobic capacity (MVO2) were recorded. All data were normalized to percentage of MVO2. Results: The mean age was 14 years in both groups (p=0.8). The gender distribution was similar (p=0.1). The mean body mass index was slightly lower in the Fontan group (23 vs 19, p=0.05). All studies were judged to be maximal. Exercise and echo data are provided below:
Is hospital admission for initiation of antiarrhythmic therapy with sotalol for atrial arrhythmias required?
Authors: Mina K Chung, Robert A Schweikert, Bruce L Wilkoff, Mark J Niebauer, Sergio L Pinski, Richard G Trohman, Gregory A Kidwell, Fredrick J Jaeger, Victor A Morant, Dave P Miller, Patrick J Tchou
Journal: Journal of the American College of Cardiology (1998)
Identification of marker allergens in Brazilian soy allergic patients
Authors: R. Cocco, D. Sole, M. Mallozi, C. Naspitz, C. Jacob, N. Wandalsen, E. Sarinho, J. LaFranco, F. Bernhardsson, S. Sjolander, M. Poorafshar, A. Kober
Journal: Allergy (2009)
A Randomized Clinical Trial of Liberal Versus Restrictive Transfusion Strategy Evaluating Long Term Survival and Cause of Death: Results from the FOCUS Trial
Authors: Jeffrey L. Carson, Frederick Sieber, Donald R Hoover, Helaine Noveck, Bernard R Chaitman, Lauren Beaupre, William Macaulay, George Rhoads, Lee Fleisher, Donald Richard Cook, David Sanders, Khwaja Zakriya, Barbara Paris, Aleksandra Zagorin, Jay Magaziner
Journal: Blood (2014)
Exome Sequencing in Chronic Lymphocytic Leukemia (CLL) and Multiple Myeloma (MM) Families Identifies Cosegregating Functional Variants
Authors: Sara Beiggi, Daniel R O'Brien, Sara J Achenbach, Kari G Rabe, Timothy G Call, Neil E Kay, Tait D Shanafelt, Aaron D Norman, Julie M Cunningham, Vincent Rajkumar, Shaji Kumar, James R Cerhan, Celine M Vachon, Susan L Slager
Journal: Blood (2014)
Timing of Tourniquet Removal after Knee Replacement
Authors: J H Newman, J P Jackson, W Waugh
Journal: Journal of the Royal Society of Medicine (1979)

This paper describes a prospective trial which was set up in order to decide whether after knee replacement it is better to remove the tourniquet (pneumatic cuff) before closure of the wound or to leave it on until compressive dressings have been applied. In 80 operations studied, there was less blood loss when the tourniquet was removed after closure and bandaging, but there was no difference in wound complications. The only statistically significant difference was attributed to the timing of tourniquet removal in those patients (about half) who were receiving low-dose heparin.