THE ANTICATALASE ACTIVITY OF SULFANILAMIDE AND SULFAPYRIDINE IN VIVO
Authors: Martin Clyman
Journal: Annals of Internal Medicine (1940)

Article1 September 1940THE ANTICATALASE ACTIVITY OF SULFANILAMIDE AND SULFAPYRIDINE IN VIVOMARTIN CLYMAN, M.D.MARTIN CLYMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-3-406 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn anticatalase activity of sulfanilamide in concentrations in vitro equivalent to those found in vivo during sulfanilamide therapy, was first observed by Main, Shinn and Mellon.13In extending these observations Locke, Main and Mellon11have concluded that hydrogen peroxide, which accumulates due to the diminished catalase activity, and not the sulfanilamide per se, is the active agent in combating bacterial infections. Hydrogen peroxide in pneumococcus cultures (Type 1, 18 hr. growth) was estimated by Shinn, Main and Mellon25who were able to detect concentrations as small as 0.0003 per cent. Retardation of growth of cultures containing sulfanilamide was accompanied by...References1. BACHZUBKOWA AS: The enzyme values of blood, Chem. Abstr., 1922, xvi, 942. Google Scholar2. BLASCHO H: The mechanism of catalase inhibitions, Biochem. Jr., 1935, xxix, 2303. CrossrefGoogle Scholar3. COULTER CB: Oxidation reduction equilibria in biological systems, Jr. Gen. Physiol., 1928, xii, 139. CrossrefGoogle Scholar4. DUBOS R: Observations on oxidation reduction properties of sterile bacteriological media, Jr. Exper. Med., 1929, xlix, 507. CrossrefGoogle Scholar5. FOXGERMANJANEWAY CLBCA: Effect of sulfanilamide on the electrode potential of hemolytic streptococcal cultures, Proc. Soc. Exper. Biol. and Med., 1939, xl, 184. CrossrefGoogle Scholar6. HEWITT LF: Oxidation reduction potentials of cultures of hemolytic streptococci, Biochem. Jr., 1930, xxiv, 512. CrossrefGoogle Scholar7. HEWITT LF: Oxidation reduction potentials of pneumococcus cultures; effect of catalase, Biochem. 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CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication March 18, 1940.Awarded the Chas. W. Burr prize for internes of the Philadelphia General Hospital, June 1939. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBiologische Oxydation und Reduktion am Stickstoff aromatischer Amino- und Nitroderivate und ihre Folgen für den OrganismusCatalase inhibition: A possible mechanism for the production of heinz bodies in erythrocytesA general theory for the mode of action of the sulfonamides * *From Wallace Laboratories, Inc., New Brunswick, N. J.Stoffwechselwirkungen der sulfonamidverbindungen an mikroorganismen über den einflu\ der sulfonamide auf den sauerstoff verbrauch von bacterium coli und bäckerhefe in synthetischen medien, sowie über beziehungen zwischen stoffwechsel- und wachstumshemmungStoffwechselwirkungen der Sulfonamidverbindungen an MikroorganismenProceedingsTenth Annual Meeting of the American Academy of Pediatrics 1 September 1940Volume 14, Issue 3Page: 406-414KeywordsAttentionPneumococcusResearch laboratories ePublished: 1 December 2008 Issue Published: 1 September 1940 PDF downloadLoading ...