HYPERTHYROIDISM AND THIOURACIL
Authors: M. Virginia Palmer
Journal: Annals of Internal Medicine (1945)

Article1 March 1945HYPERTHYROIDISM AND THIOURACILM. VIRGINIA PALMERM. VIRGINIA PALMERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-3-335 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI. INTRODUCTIONIn the past few years an extensive literature has evolved concerning goitrogens and the goitrogenous state. Some of the results are confusing and some are still of unknown significance, because our knowledge of thyroid physiology is incomplete and the concept of the pituitary-thyroid axis is not thoroughly understood. What causes the thyroid gland to function abnormally, and what is affected by this abnormal function? How exclusive is the importance of the thyroid in Graves' disease, and what is the importance of the pituitary-thyroid axis in relation to the adrenal glands, the hypothalamus and the autonomic nervous system, and...Bibliography1. ASTWOOD EB: Treatment of hyperthyroidism with thiourea and thiouracil, Jr. Am. Med. Assoc., 1943, cxxii, 78. CrossrefGoogle Scholar2. ASTWOODBISSELL EBA: Effect of thiouracil on the iodine content of the thyroid gland, Endocrinology, 1944, xxxiv, 282. CrossrefGoogle Scholar3. ASTWOODSULLIVANBISSELLTESLOWITZ EBJAR: Action of certain sulfonamides and of thiourea upon the function of the thyroid gland of the rat, Endocrinology, 1943, xxxii, 224. Google Scholar4. DEMPSEY EW: Fluorescent and histochemical reactions in the rat thyroid gland at different states of physiological activity, Endocrinology, 1944, xxxiv, 27. CrossrefGoogle Scholar5. FRAZIERRAVDIN WDIS: The use of vitamin B in the preoperative preparation of the hyperthyroid patient, Surgery, 1938, iv, 680. Google Scholar6. HERTZROBERTS SA: Radioactive iodine as an indicator in thyroid physiology. III. Iodine collection as a criterion of thyroid function in rabbits injected with thyrotropic hormone, Endocrinology, 1941, xxix, 82. CrossrefGoogle Scholar7. MACKENZIEMACKENZIE JBCG: Effect of sulfonamides and thioureas on the thyroid gland and basal metabolism, Endocrinology, 1943, xxxii, 208. Google Scholar8. MACKENZIEMACKENZIEMCCOLLUM JBCGEV: Effect of sulfanilylguanidine on the thyroid of the rat, Science, 1941, xciv, 518. CrossrefGoogle Scholar9. MEANS JH: Some new approaches to the physiology of the thyroid, Ann. Int. Med., 1943, xix, 567. Google Scholar10. MEANSHERTZWILLIAMS JHSRH: Graves' disease with dissociation of thyrotoxicosis and ophthalmopathy, Trans. Assoc. Am. Phys., 1941, lvi, 72. Google Scholar11. RAWSONTANNHEIMERPEACOCK RWJFW: The uptake of radioactive iodine by the thyroids of rats made goiterous by potassium thiocyanate and by thiouracil, Endocrinology, 1944, xxxiv, 245. CrossrefGoogle Scholar12. RICHTERCLISBY CPKH: Graying of hair produced by ingestion of phenylthiocarbamide, Proc. Soc. Exper. Biol. and Med., 1941, xlviii, 684; Toxic effects of the bitter tasting phenylthiocarbamide, Arch. Path., 1942, xxxiii, 46. CrossrefGoogle Scholar13. WEBSTERCHESNEY RAM: Endemic goitre in rabbits. III. Effect of administration of iodine, Bull. Johns Hopkins Hosp., 1928, xliii, 291. Google Scholar14. WILLIAMSBISSELL RHGW: Thiouracil in the treatment of thyrotoxicosis, New England Jr. Med., 1943, ccxxix, 97. CrossrefGoogle Scholar15. WILLIAMSEGANAROBINSONASPERDUTOIT RHEPSPC: Alterations in biological oxidation in thyrotoxicosis. I. Thiamin metabolism, Arch. Int. Med., 1943, lxxii, 353. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication May 24, 1944.From the Department of Medicine, University Hospital, Baltimore. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Thyroid Gland in PregnancyManagement of Hyperthyroidism during PregnancyTHIOURACIL IN PREGNANCYThiourea Derivatives and the Fetus**Work supported in part by the Fiftieth Anniversary Fund of the Chicago Lying-in Hospital and the Benjamin J. Rosenthal Post Doctoral Fellowship in the Department of Pediatrics, University of Chicago.Hyperthyroidism and pregnancyTHIOURACIL AND THYROTOXICOSISThiouracil: Remission or relapse of hyperthyroidism after discontinuing its useTHIOURACIL DERIVATIVES AND PREGNANCY1Conservative treatment of thyrotoxicosis with thiouracilEffect of 6-methyl-2-thiouracil on Rat Foetuses and Infantile RatsTHIOURACILDENTAL RESEARCH UNIT FOR LONDONCretinismTHIOURACIL IN GOITRE 1 March 1945Volume 22, Issue 3Page: 335-364KeywordsAdrenal glandsAutonomic nervous systemHospital medicineHyperthyroidismHypothalamusThyroid ePublished: 1 December 2008 Issue Published: 1 March 1945 Copyright & PermissionsCopyright, 1945, by The American College of PhysiciansPDF downloadLoading ...