tbuckley/cabot-search huggingface dataset:
Neuropsychological Assessments of Cognitive Impairment in Major Depressive Disorder: A Systematic Review and Meta-Analysis with Meta-Regression
Authors: Taeho Greg Rhee, Sung Ryul Shim, Kevin J Manning, Howard A Tennen, Tyler S Kaster, Giacomo d'Andrea, Brent P Forester, Andrew A Nierenberg, Roger S McIntyre, David C Steffens
Journal: Psychotherapy and Psychosomatics (2024)

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Cognitive dysfunction or deficits are common in patients with major depressive disorder (MDD). The current study systematically reviews and meta-analyzes multiple domains of cognitive impairment in patients with MDD. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; PubMed/MEDLINE, PsycINFO, Cochrane Library, Embase, Web of Science, and Google Scholar were searched from inception through May 17, 2023, with no language limits. Studies with the following inclusion criteria were included: (1) patients with a diagnosis of MDD using standardized diagnostic criteria; (2) healthy controls (i.e., those without MDD); (3) neuropsychological assessments of cognitive impairment using Cambridge Neuropsychological Test Automated Battery (CANTAB); and (4) reports of sufficient data to quantify standardized effect sizes. Hedges’ &lt;i&gt;g&lt;/i&gt; standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs) were used to quantify effect sizes of cognitive impairments in MDD. SMDs were estimated using a fixed- or random-effects models. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Overall, 33 studies consisting of 2,596 subjects (&lt;i&gt;n&lt;/i&gt; = 1,337 for patients with MDD and &lt;i&gt;n&lt;/i&gt; = 1,259 for healthy controls) were included. Patients with MDD, when compared to healthy controls, had moderate cognitive deficits (SMD, −0.39 [95% CI, −0.47 to −0.31]). In our subgroup analyses, patients with treatment-resistant depression (SMD, −0.56 [95% CI, −0.78 to −0.34]) and older adults with MDD (SMD, −0.51 [95% CI, −0.66 to −0.36]) had greater cognitive deficits than healthy controls. The effect size was small among unmedicated patients with MDD (SMD, −0.19 [95% CI, −0.37 to −0.00]), and we did not find any statistical difference among children. Cognitive deficits were consistently found in all domains, except the reaction time. No publication bias was reported. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Because cognitive impairment in MDD can persist in remission or increase the risk of major neurodegenerative disorders, remediation of cognitive impairment in addition to alleviation of depressive symptoms should be an important goal when treating patients with MDD.
PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway
Authors: Hao Gu, Chiqi Chen, Zhi-Shuai Hou, Xia-Di He, Shaozhen Xie, Jing Ni, Changli Qian, Xin Cheng, Tao Jiang, Ce Yang, Thomas M. Roberts, Junke Zheng, Judith A. Varner, Scott A. Armstrong, Jean J. Zhao
Journal: Blood (2024)
Intergenerational Transmission of Ethnoracial Historical Trauma in the United States
Authors: Donna K. Nagata, Jacqueline H.J. Kim, Joseph P. Gone
Journal: Annual Review of Clinical Psychology (2024)

Throughout time, ethnoracial groups have endured a range of traumatic experiences as historically marginalized members of the United States. The consequences of these experiences have been referred to as historical trauma (HT): a collective trauma, inflicted on a group of people who share a specific identity, that has psychological, physical, and social impacts on succeeding generations. In this review, we examine the literature on HT in relation to US ethnoracial groups by defining HT, providing a background for its development, and describing critiques of the concept. We then review the literature on HT in relation to Indigenous Americans, African Americans, and Asian Americans. For each group, we address the nature of HT, the transmission of HT and its impacts, and healing strategies. We conclude with a summary of the benefits, limitations, and complexities of HT research as well as recommendations for future work in this area.
Impostor Phenomenon in Racially/Ethnically Minoritized Groups: Current Knowledge and Future Directions
Authors: Kevin O. Cokley, Donte L. Bernard, Steven Stone-Sabali, Germine H. Awad
Journal: Annual Review of Clinical Psychology (2024)

In recent years there has been a surge of research conducted on the impostor phenomenon, with approximately half of all impostor phenomenon articles being published between 2020 and 2022 and growing interest in understanding how the impostor phenomenon affects racially and ethnically minoritized individuals. Questions around intersectionality remain about how to apply the impostor phenomenon to the experiences of minoritized individuals. In this review, we revisit the historical context of the impostor phenomenon. We address issues of nomenclature and current controversies regarding whether the impostor phenomenon (
Leveraging Microbiome Composition Variability for Precision Medicine in Idiopathic Pulmonary Fibrosis
Authors: Hajime Fujimoto, Corina N. D'Alessandro-Gabazza, Taro Yasuma, Esteban C Gabazza, Osamu Hataji, Tetsu Kobayashi
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Leveraging Microbiome Composition Variability for Precision Medicine in Idiopathic Pulmonary Fibrosis." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Versatile Antibacterial and Antioxidant Bacterial Cellulose@Nanoceria Biotextile: Application in Reusable Antimicrobial Face Masks
Authors: Jie Tang, Yuping Zhang, Xingfei Liu, Yichao Lin, Lihua Liang, Xiaofang Li, Gregori Casals, Xiangyu Zhou, Eudald Casals, Muling Zeng
Journal: Advanced Healthcare Materials (2024)

Abstract Despite considerable interest in medical and pharmaceutical fields, there remains a notable absence of functional textiles that concurrently exhibit antibacterial and antioxidant properties. Herein, a new composite fabric constructed using nanostructured bacterial cellulose (BC) covalently‐linked with cerium oxide nanoparticles (BC@CeO 2 NPs) is introduced. The synthesis of CeO 2 NPs on the BC is performed via a microwave‐assisted, in situ chemical deposition technique, resulting in the formation of mixed valence Ce 3+ /Ce 4+ CeO 2 NPs. This approach ensures the durability of the composite fabric subjected to multiple washing cycles. The Reactive oxygen species (ROS) scavenging activity of CeO 2 NPs and their rapid and efficient eradication of &gt;99% model microbes, such as Escherichia coli , Pseudomonas aeruginosa and Staphylococcus aureus remain unaltered in the composite. To demonstrate the feasibility of incorporating the fabric in marketable products, antimicrobial face masks are fabricated with filter layers made of BC@CeO 2 NPs cross‐linked with propylene or cotton fibers. These masks exhibit complete inhibition of bacterial growth in the three bacterial strains, improved breathability compared to respirator masks and enhanced filtration efficiency compared to single‐use surgical face masks. This study provides valuable insights into the development of functional BC@CeO 2 NPs biotextiles in which design can be extended to the fabrication of medical dressings and cosmetic products with combined antibiotic, antioxidant and anti‐inflammatory activities.
Reply to: Ventilatory Burden in Obstructive Sleep Apnea: A Novel Indicator for Assessing Severity?
Authors: Ankit Parekh, Korey Kam, Sajila Wickramaratne, Thomas M. Tolbert, Andrew W. Varga, Ricardo S. Osorio, Monica L. Andersen, Luciana B. M. de Godoy, Luciana O. Palombini, Sergio Tufik, Indu Ayappa, David M. Rapoport
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Reply to: Ventilatory Burden in Obstructive Sleep Apnea: A Novel Indicator for Assessing Severity?." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
The CD4 Versus CD8 T Cell Fate Decision: A Multiomics-Informed Perspective
Authors: Zoë Steier, Esther Jeong Yoon Kim, Dominik A. Aylard, Ellen A. Robey
Journal: Annual Review of Immunology (2024)

The choice of developing thymocytes to become CD8 + cytotoxic or CD4 + helper T cells has been intensely studied, but many of the underlying mechanisms remain to be elucidated. Recent multiomics approaches have provided much higher resolution analysis of gene expression in developing thymocytes than was previously achievable, thereby offering a fresh perspective on this question. Focusing on our recent studies using CITE-seq (cellular indexing of transcriptomes and epitopes) analyses of mouse thymocytes, we present a detailed timeline of RNA and protein expression changes during CD8 versus CD4 T cell differentiation. We also revisit our current understanding of the links between T cell receptor signaling and expression of the lineage-defining transcription factors ThPOK and RUNX3. Finally, we propose a sequential selection model to explain the tight linkage between MHC-I versus MHC-II recognition and T cell lineage choice. This model incorporates key aspects of previously proposed kinetic signaling, instructive, and stochastic/selection models.
Ventilatory Burden in Obstructive Sleep Apnea: A Novel Indicator for Assessing Severity?
Authors: Qiming Gan, Yuting Zhang, Quanzhen Liu, Nuofu Zhang, Kang Wu
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Ventilatory Burden in Obstructive Sleep Apnea: A Novel Indicator for Assessing Severity?." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
E-Cigarettes as a Smoking Cessation Aid – Has ASH Made a HASH of Its Stance on Nicotine-based Vaping?
Authors: Robert P. Young, Raewyn J. Scott, Philip K. Pattemore, Letitia Harding
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"E-Cigarettes as a Smoking Cessation Aid – Has ASH Made a HASH of Its Stance on Nicotine-based Vaping?." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
The Rise of Adaptive Platform Trials in Critical Care
Authors: Lieuwe D. J. Bos, Carolyn Calfee, Andrea Castellvi-Font, Victoria Cornelius, Lennie P. G. Derde, Annemarie Docherty, Eddy Fan, Niall Ferguson, Ewan C. Goligher, Anthony C. Gordon, Anders Granholm, Michael O. Harhay, Anna Heath, Maj-Brit Nørregaard Kjær, Patrick R. Lawler, Nazir Lone, Danny McAuley, Morten Hylander Møller, Laveena Munshi, Srinivas Murthy, Alistair D. Nichol, Anders Perner, Kiran Reddy, Bram Rochwerg, Kathy Rowan, Sarina Sahetya, Manu Shankar-Hari, Steve Webb, Christopher Weir, Ryan Zarychanski
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"The Rise of Adaptive Platform Trials in Critical Care." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Maternal-Fetal Connections in Prenatal Respiratory Disease: Time to Address Intrauterine Inflammation
Authors: Elizabeth S. Taglauer, Karen K. Mestan
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Maternal-Fetal Connections in Prenatal Respiratory Disease: Time to Address Intrauterine Inflammation." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Airway ‘Resistotypes’ and Clinical Outcomes in Bronchiectasis
Authors: Micheál Mac Aogáin, Fransiskus Xaverius Ivan, Tavleen Kaur Jaggi, Hollian Richardson, Amelia Shoemark, Jayanth Kumar Narayana, Alison J. Dicker, Mariko Siyue Koh, Ken Cheah Hooi Lee, Ong Thun How, Mau Ern Poh, Ka Kiat Chin, Albert Lim Yick Hou, Puah Ser Hon, Teck Boon Low, John Arputhan Abisheganaden, Katerina Dimakou, Antonia Digalaki, Chrysavgi Kosti, Anna Gkousiou, Philip M. Hansbro, Francesco Blasi, Stefano Aliberti, James D. Chalmers, Sanjay H. Chotirmall
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

Chronic infection and inflammation shapes the airway microbiome in bronchiectasis. Utilizing whole-genome shotgun metagenomics to analyze the airway resistome provides insight into interplay between microbes, resistance genes, and clinical outcomes.
The Lung Microbiome Predicts Mortality and Response to Azithromycin in Lung Transplant Patients with Chronic Rejection
Authors: Michael P. Combs, Jenna E. Luth, Nicole R. Falkowski, David S. Wheeler, Natalie M. Walker, John R. Erb-Downward, Elliot Wakeam, Michael W. Sjoding, Daniel G. Dunlap, Andrew J. Admon, Robert P. Dickson, Vibha N. Lama
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

Chronic lung allograft dysfunction (CLAD) is the leading cause of death after lung transplant, and azithromycin has variable efficacy in CLAD. The lung microbiome is a risk factor for developing CLAD, but the relationship between lung dysbiosis, pulmonary inflammation, and allograft dysfunction remains poorly understood. Whether lung microbiota predict outcomes or modify treatment response
Effectiveness of Fludrocortisone Plus Hydrocortisone versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Authors: Bijan Teja, Megan Berube, Tiago V. Pereira, Anica C. Law, Carly Schanock, Brandon Pang, Hannah Wunsch, Allan J. Walkey, Nicholas A. Bosch
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

Rationale: The use of hydrocortisone in adult septic shock is controversial, and effectiveness of adding fludrocortisone to hydrocortisone remains uncertain. Objective: To assess comparative effectiveness and safety of fludrocortisone plus hydrocortisone, hydrocortisone alone and placebo/usual care in adults with septic shock. Methods: Systematic review and Bayesian network meta-analysis of peer-reviewed randomized trials. The primary outcome was all-cause mortality at last follow-up. Treatment effects were presented as relative risks (RR) with 95% credible intervals (CrI). Placebo/usual care was the reference treatment. Main Results: Out of 7,553 references, we included 17 trials (7,688 patients). All-cause mortality at last follow-up was lowest with fludrocortisone plus hydrocortisone (RR: 0.85, 95% CrI: 0.72-0.99, 98.3% probability of superiority, moderate-certainty evidence), followed by hydrocortisone alone (RR: 0.97, 95% CrI: 0.87-1.07, 73.1% probability of superiority, low-certainty evidence). The comparison of fludrocortisone plus hydrocortisone versus hydrocortisone alone was primarily based on indirect evidence (only two trials with direct evidence). Fludrocortisone plus hydrocortisone was associated with a 12% lower risk of all-cause mortality compared to hydrocortisone alone (RR: 0.88, 95% CrI: 0.74-1.03, 94.2% probability of superiority, moderate-certainty evidence). Conclusions: In adult septic shock patients, fludrocortisone plus hydrocortisone was associated with lower risk of all-cause mortality at last follow-up than placebo and hydrocortisone alone. The scarcity of head-to-head trials comparing fludrocortisone plus hydrocortisone versus hydrocortisone alone led our network meta-analysis to rely primarily on indirect evidence for this comparison. Though we undertook several sensitivity analyses and assessments, these findings should be considered while also acknowledging the heterogeneity of included trials.
Targeting Src SH3 domain–mediated glycolysis of HSC suppresses transcriptome, myofibroblastic activation, and colorectal liver metastasis
Authors: Yuanguo Wang, Xianghu Wang, Bing Bai, Aurpita Shaha, Xipu He, Yingzi He, Zhenqing Ye, Vijay H. Shah, Ningling Kang
Journal: Hepatology (2024)

Transforming growth factor-beta 1 (TGFβ1) induces HSC activation into metastasis-promoting cancer-associated fibroblasts (CAFs), but how the process is fueled remains incompletely understood. We studied metabolic reprogramming induced by TGFβ1 in HSCs.
Silicosis in Western U.S. Metal and Nonmetal Miners, 2002–2023
Authors: Lauren M. Zell-Baran, Jeremy T. Hua, Cecile S. Rose
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Silicosis in Western U.S. Metal and Nonmetal Miners, 2002–2023." American Journal of Respiratory and Critical Care Medicine, 209(6), pp. 756–758
The Association between Bronchiectasis and Chronic Obstructive Pulmonary Disease: Data from the European Bronchiectasis Registry (EMBARC)
Authors: Eva Polverino, Anthony De Soyza, Katerina Dimakou, Letizia Traversi, Apostolos Bossios, Megan L. Crichton, Felix C Ringshausen, Montserrat Vendrell, Pierre-Regis Burgel, Charles S. Haworth, Michael R. Loebinger, Natalie Lorent, Isabell Pink, Melissa McDonnell, Sabina Skrgat, Luis Maiz Carro, Oriol Sibila, Menno M. vd Eerden, Paula Kauppi, Amelia Shoemark, Adelina Amorim, Jeremy S. Brown, John R Hurst, Marc Miravitlles, Rosario Menendez, Antoni Torres, Tobias Welte, Francesco Blasi, Josje Altenburg, Michal Shteinberg, Wim Boersma, Stuart J. Elborn, Pieter C. Goeminne, Stefano Aliberti, James D. Chalmers
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

COPD and bronchiectasis are commonly reported together. Studies report varying impacts of co-diagnosis on outcomes, which may be related to different definitions of disease used across studies.
Relational place-based solutions for environmental policy misalignments
Authors: Hannah M. Kobluk, Anne K. Salomon, Adam T. Ford, Andrew N. Kadykalo, Mateen A. Hessami, Pierre-Alexandre Labranche, Carmen Richter, Wendy J. Palen, ḥapinyuuk Tommy Happynook, Murray M. Humphries, Elena M. Bennett
Journal: Trends in Ecology & Evolution (2024)

Current reductionist approaches to environmental governance cannot resolve social-ecological crises. Siloed institutions fail to address linked social and ecological processes, thereby neglecting issues of equity, justice, and cumulative effects. Global insights can be gained from Indigenous-led initiatives that support the resilience of relationships within and among places.
EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3
Authors: Gan Wu, Ben Cao, Haige Zhai, Bin Liu, Yuan Huang, Xiaowei Chen, Hanzhi Ling, Sunwang Ling, Shengwei Jin, Xinyu Yang, Jianguang Wang
Journal: Annals of the Rheumatic Diseases (2024)

Objective Erythropoietin (EPO) known as an erythrocyte-stimulating factor is increased in patients with rheumatoid arthritis (RA). Nevertheless, the function of EPO in the process of RA and relative mechanism needs to be further clarified. Methods The level of EPO in serum and synovial fluid from patients with RA and healthy controls was determined by . Collagen-induced arthritis (CIA) mice were constructed to confirm the role of EPO on RA pathogenesis. Differentially expressed genes (DEGs) of EPO-treated fibroblast-like synoviocyte (FLS) were screened by transcriptome sequencing. The transcription factor of neuraminidase 3 (NEU3) of DEGs was verified by double luciferase reporting experiment, DNA pulldown, electrophoretic mobility shift assay and chromatin immunoprecipitation-quantitative PCR (qPCR) assay. Results The overexpression of EPO was confirmed in patients with RA, which was positively associated with Disease Activity Score 28-joint count. Additionally, EPO intervention could significantly aggravate the joint destruction in CIA models. The upregulation of NEU3 was screened and verified by transcriptome sequencing and qPCR in EPO-treated FLS, and signal transducer and activator of transcription 5 was screened and verified to be the specific transcription factor of NEU3. EPO upregulates NEU3 expression via activating the Janus kinase 2 (JAK2)-STAT5 signalling pathway through its receptor EPOR, thereby to promote the desialylation through enhancing the migration and invasion ability of FLS, which is verified by JAK2 inhibitor and NEU3 inhibitor. Conclusion EPO, as a proinflammatory factor, accelerates the process of RA through transcriptional upregulation of the expression of NEU3 by JAK2/STAT5 pathway.
Use of isotretinoin among girls and women of childbearing age and occurrence of isotretinoin-exposed pregnancies in Germany: A population-based study
Authors: Jonas Reinold, Bianca Kollhorst, Nadine Wentzell, Katharina Platzbecker, Ulrike Haug
Journal: PLoS Medicine (2024)

Background Exposure to isotretinoin during pregnancy must be avoided due to its teratogenicity, but real-world data on its use are scarce. We aimed to describe (i) isotretinoin use in women of childbearing age in Germany; (ii) the occurrence of isotretinoin-exposed pregnancies; and (iii) malformations among children exposed in utero. Methods and findings Using observational data from the German Pharmacoepidemiological Research Database (GePaRD, claims data from approximately 20% of the German population), we conducted annual cross-sectional analyses to determine age-standardized prevalence of isotretinoin use between 2004 and 2019 among girls and women aged 13 to 49 years. In cohort analyses, we estimated the number of exposed pregnancies by assessing whether there was prescription supply overlapping the beginning of pregnancy (estimated supply was varied in sensitivity analyses) or a dispensation within the first 8 weeks of pregnancy. Data of live-born children classified as exposed in a critical period according to these criteria were reviewed to assess the presence of congenital malformations. The age-standardized prevalence of isotretinoin use per 1,000 girls and women increased from 1.20 (95% confidence interval [CI]: 1.16, 1.24) in 2004 to 1.96 (95% CI: 1.92, 2.01) in 2019. In the base case analysis, we identified 178 pregnancies exposed to isotretinoin, with the number per year doubling during the study period, and at least 45% of exposed pregnancies ended in an induced abortion. In sensitivity analyses, the number of exposed pregnancies ranged between 172 and 375. Among live-born children, 6 had major congenital malformations. The main limitation of this study was the lack of information on the prescribed dose, i.e., the supply had to be estimated based on the dispensed amount of isotretinoin. Conclusions Isotretinoin use among girls and women of childbearing age increased in Germany between 2004 and 2019, and there was a considerable number of pregnancies likely exposed to isotretinoin in a critical period. This highlights the importance of monitoring compliance with the existing risk minimization measures for isotretinoin in Germany.