tbuckley/cabot-search huggingface dataset:
Mumps outbreak in young adults following a festival in Austria, 2006
Authors: D Schmid, H Holzmann, C Alfery, H Wallenko, T H Popow-Kraupp, F Allerberger
Journal: Eurosurveillance (2008)

Mumps is not a mandatorily notifiable disease in Austria. However, in the first week of May 2006, a sudden increase in serologically confirmed cases of mumps, confined to three public health districts of the southern Austrian province of Carinthia, was identified by the Austrian Reference laboratory for MMR. An epidemiological investigation of this cluster of mumps cases was performed. A total of 214 cases fulfilled the outbreak case definition; 143 cases were laboratory confirmed and 71 cases were epidemiologically linked and fulfilled the clinical picture of the case definition. The vaccination status was known for 169 patients. Nearly half of the cases for whom the vaccination status was known occurred in non-vaccinated persons, another 40% were vaccinated with one dose of the vaccine and 11% had received two doses. Only four mumps cases occurred in children aged 14 years or younger, indicating that the vaccination coverage and the acceptance of the recommended childhood vaccinations have strongly improved within the past 15 years. Vaccination scheme failure but not vaccine failure is primarily to blame for this mumps outbreak.
Abstract 4464: Impact of Thromboaspiration during Primary PCI on Infarcted Segmental Myocardial Function: A Tissue Doppler Imaging Evaluation. EXPIRA Trial Substudy
Authors: Gennaro Sardella, Massimo Mancone, Raffaele Scardala, Giulia Conti, Angelo Di Roma, Giulia Benedetti, Lorenzo Maria Zuccaro, Marco Rebecchi, Francesco Fedele
Journal: Circulation (2008)
Remote-Controlled Radium Emanation Plant and Automatic Measuring Apparatus for Gold Implants&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: John E. Rose, Robert W. Swain
Journal: JNCI Journal of the National Cancer Institute (1949)

Remote-Controlled Radium Emanation Plant and Automatic Measuring Apparatus for Gold Implants Get access John E. Rose, John E. Rose physicist Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert W. Swain Robert W. Swain physicist U. S. Marine Hospital, Baltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 3, December 1949, Pages 605–623, https://doi.org/10.1093/jnci/10.3.605 Published: 01 December 1949 Article history Received: 05 August 1949 Published: 01 December 1949
Initial Phase 3 Results Of The First (Frontline Investigation Of Lenalidomide + Dexamethasone Versus Standard Thalidomide) Trial (MM-020/IFM 07 01) In Newly Diagnosed Multiple Myeloma (NDMM) Patients (Pts) Ineligible For Stem Cell Transplantation (SCT)
Authors: Thierry Facon, Meletios A. Dimopoulos, Angela Dispenzieri, John V. Catalano, Andrew R Belch, Cyrille Hulin, Michele Cavo, Antonella Pinto, Katja Weisel, Heinz Ludwig, Nizar J. Bahlis, Anne Banos, Mourad Tiab, Michel Delforge, James D Cavenagh, Catarina Geraldes, Je-Jung Lee, Christine I. Chen, Albert Oriol, Javier De La Rubia, Lugui Qiu, Darrell J. White, Daniel Binder, Kenneth C. Anderson, Philippe Moreau, Michel Attal, Robert Knight, Guang Chen, Jason Van Oostendorp, Christian J. Jacques, Annette Ervin-Haynes, Lofti Benboubker
Journal: Blood (2013)
Abstract 10730: Patterns of Aortic Dilatation in Bicuspid Aortic Valve-Associated Aortopathy
Authors: Clarence Khoo, John Jue
Journal: Circulation (2011)

BACKGROUND: Bicuspid aortic valves (BAV) are associated with aortopathy. Recent studies suggest that aortic dilatation is more likely to be seen with left/right coronary cusp fusion (Type I) compared to right/non-coronary cusp fusion (Type II). Results in the published literature, however, have been divergent. METHODS: Aortic dimensions and BAV morphology were obtained retrospectively from archived cineloops of 581 consecutive BAV patients. Measurements were performed at the aortic root (annulus & sinus of Valsalva), and the tubular aorta (sinotubular junction & proximal ascending aorta). Patient demographics and other echocardiographic parameters were extracted from the database. RESULTS: The study population was comprised of 71% Type I BAV (415 patients), and 26% Type II BAV (149 patients). Concomitant aortic coarctation was infrequent at 2%. Aortic dilatation was present in 27% of the population. Type I BAV was associated with increased dimensions at the sinus of Valsalva compared with Type II BAV (18 ...
Abstract 20044: Percutaneous Mitral Annuloplasty is Associated with Durable Reduction in Functional Mitral Regurgitation and Left Ventricular Reverse Remodeling in Patients with Symptomatic Heart Failure
Authors: Amil Shah, Scott D Solomon, Jacek Myc, Olga Jerzykowska, Matthias Breise, Fotini Dodos, Olivier Fondard, Etienne Geoffroy, Laura Ernande, Severine Monzy, Nawzer Mehta, David G Reuter, Justina C Wu
Journal: Circulation (2010)

Background: Functional mitral regurgitation (FMR) in patients with heart failure (HF) is associated with worse outcomes. The long term impact of percutaneous mitral annuloplasty (PMA) on FMR severi...
Abstract 15033: A Prediction Model for Short Length of Stay among Patients Admitted with Congestive Heart Failure
Authors: Eric L Bonno, Michael C Gavin, Lisa M Fleming, Kenneth Mukamal, James D Chang
Journal: Circulation (2012)

Introduction:  Risk stratification for length of stay (LOS) among patients hospitalized with heart failure (HF) may be useful for identifying patients likely to have a short LOS for whom management in a short-stay observation unit would be possible.   Methods:  We studied 3643 consecutive admissions discharged from a single urban academic medical center between October 2007 and August 2011 with a primary diagnosis of HF based on billing code. We developed a prediction tool for short LOS (defined as ≤ 48 hours) using generalized estimating equations, with three-quarters of the hospitalizations randomly selected as the derivation cohort and one-quarter as the validation cohort. Candidate predictors included sociodemographic and clinical characteristics, initial laboratory results, and vital signs.   Results:  The probabilities of short LOS were similar in the derivation [31.5%] and validation [33.8%] cohorts. Admission day of the week, sodium, hematocrit, blood urea nitrogen, creatinine, HF admission within the previous 30 days, and suspicion of ischemia (defined as measurement of troponin on admission) were significantly associated with likelihood of short LOS. The base model incorporating these data had good discrimination (C-statistic of 0.65 in the derivation set and 0.67 in the validation set). The model was well calibrated with similar predicted / observed risks of short LOS across tertiles in the derivation (19% / 18%, 32% / 33%, 43% / 45%) and validation (19% / 20%, 33% / 30%, 46% / 52%) cohorts. Initial vital signs and brain natriuretic peptide (BNP) were available in 1362 and 1842 hospitalizations in the derivation cohort subjects, respectively. Heart rate, systolic blood pressure, respiratory rate, and BNP were associated with short LOS. In these subgroups, adding vital signs or BNP modestly improved the base model’s discrimination (C-statistics 0.68 and 0.67, respectively).   Conclusions:  We developed and validated a model predicting short LOS among patients hospitalized with HF using routinely collected biochemical and physiologic data. Given the high cost of inpatient HF care, use of such a model to identify patients who can be managed either as an outpatient or in a short-stay observation unit may present a cost-saving strategy.
The Role BAFF and BAFF Receptors in Macrophage Induced Drug Resistance of Multiple Myeloma
Authors: Jing Chen, Donghua He, Xing Guo, Li Yang, Yi Li, Qingxiao Chen, Jingsong He, Yang Yang, Enfan Zhang, WenJun Wu, Xiaoyan Han, Gaofeng Zheng, Yi Zhao, He Huang, Zhen Cai
Journal: Blood (2014)
Physical Activity in Older Subjects Is Associated With Increased Coronary Vasodilation
Authors: Patricia K. Nguyen, Masahiro Terashima, Joan M. Fair, Ann Varady, Ruth E. Taylor-Piliae, Carlos Iribarren, Alan S. Go, William L. Haskell, Mark A. Hlatky, Stephen P. Fortmann, Michael V. McConnell
Journal: JACC. Cardiovascular imaging (2011)
THE INCIDENCE OF THE CLINICAL TYPES OF SYPHILIS IN MALES, IN PREGNANT AND NON-PREGNANT FEMALES
Authors: William C. Menninger, Jarold E. Kemp
Journal: Annals of Internal Medicine (1935)

Article1 August 1935THE INCIDENCE OF THE CLINICAL TYPES OF SYPHILIS IN MALES, IN PREGNANT AND NON-PREGNANT FEMALESWILLIAM C. MENNINGER, M.D., F.A.C.P., JAROLD E. KEMP, M.D.WILLIAM C. MENNINGER, M.D., F.A.C.P.Search for more papers by this author, JAROLD E. KEMP, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-2-175 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a series of studies of neurosyphilis we1 reported the incidence of neurosyphilis in males, nullipara and multipara.† In order to make a comparison of the incidence of neurosyphilis with other types of syphilis in the same groups we have reviewed 800 cases of syphilis as they were admitted to a large venereal disease clinic or were under routine treatment. Our findings are reported in this paper.In the selection of these cases, patients with early syphilis as well as those with late syphilis, with minor pupillary or reflex changes not diagnostic of neurosyphilis, who had not had an examination...Reference1. KEMPMENNINGER JEWC: The incidence of neurosyphilis in males, in pregnant and in non-pregnant females. (In press.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 18, 1935.†In the group of multipara are included only those women with a history of one or more pregnancies, of at least five months' duration, subsequent to their syphilitic infection. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe epidemiology of syphilis 1 August 1935Volume 9, Issue 2Page: 175-177KeywordsPregnancyReflexesSexually transmitted diseasesSyphilis ePublished: 1 December 2008 Issue Published: 1 August 1935 PDF downloadLoading ...
Comparison Of Deep Sequencing and Allele-Specific Oligonucleotide PCR Methods For MRD Quantitation In Acute Lymphoblastic Leukemia and Mantle Cell Lymphoma: CALGB 10403 and CALGB 59909 (Alliance)
Authors: Greg Malnassy, Susan Geyer, Noreen Fulton, Greg Koval, Donna Niedzwiecki, Victoria Carlton, Li Weng, Lawrence D. Kaplan, Guido Marcucci, Lloyd E Damon, Richard A. Larson, Richard M. Stone, Bruce D. Cheson, Malek Faham, Wendy Stock
Journal: Blood (2013)
Proposed changes in DSM-III substance use disorders: description and rationale
Authors: Bruce J. Rounsaville, Robert L. Spitzer, Janet B. Williams
Journal: American Journal of Psychiatry (1986)

The authors describe changes in DSM-III substance use disorders to be included in the revised version, DSM-III-R. Major revisions include removal of the distinction between "abuse" and "dependence" and broadening the definition of "dependence" to a syndrome of clinically significant behaviors that indicate a serious degree of involvement with psychoactive drugs; creation of a new category of "psychoactive substance neuroadaptation syndrome" for individuals whose physiological adaptations to high doses of psychoactive substances did not arise from their own behavior; use of an identical set of symptoms and behaviors to determine dependence on all different classes of psychoactive substances; and provision of a system for rating severity of dependence.
Early and long-term (one-year) effects of the association of aspirin and oral anticoagulant on thrombi and morbidity after replacement of the mitral valve with the st. jude medical prosthesis
Authors: Patrick Laffort, Raymond Roudaut, Xavier Roques, Stéphane Lafitte, Claude Deville, Jacques Bonnet, Eugene Baudet
Journal: Journal of the American College of Cardiology (2000)
Exploring Different Phenotypes of COPD
Authors: Frank E. Speizer, James H. Ware
Journal: New England Journal of Medicine (2015)

Chronic obstructive pulmonary disease (COPD) is among the five leading causes of death in the developed world and is a rapidly rising cause of death in most other countries.1 Cigarette smoking is clearly the predominant cause of the development of COPD, but there has been speculation for some time that other factors need to be considered in assessing risk of the disease. The report by Lange et al.2 in this issue of the Journal describes results obtained from three longitudinal cohort studies involving adults (age range, 25 to 40 years in two cohorts and 31 to 75 years in the . . .
Abstract 9522: Hs-CRP, Statin Therapy, and Risks of Atrial Fibrillation: An Exploratory Analysis of the JUPITER Trial
Authors: Jessica M Peña, Paul M Ridker, Jean MacFadyen, Robert J Glynn
Journal: Circulation (2011)

Objective: We studied whether high-sensitivity C-reactive protein (hs-CRP) is associated with incident atrial fibrillation (AF) and whether treatment with rosuvastatin is associated with a lower incidence of AF compared with placebo. Background: Increasing evidence supports a role for inflammation in promoting AF and statins have anti-inflammatory effects that may be relevant for the prevention of AF. However, studies of statin therapy and incident AF have yielded mixed results and not focused on those with an underlying pro-inflammatory response. Methods and Results: The JUPITER trial randomized men and women with LDL-C &lt; 130 mg/dL and hs-CRP ≥ 2 mg/dl to receive either rosuvastatin 20 mg daily or placebo. AF was determined from treatment-blind adverse event reports. Among 17,120 JUPITER participants with no prior history of AF or arrhythmia, each increasing tertile of baseline hs-CRP was associated with a 36% increase in the risk of developing AF( 95% CI 1.16-1.60 p-trend &lt;0.01). Random allocation to rosuvastatin as compared with placebo was associated with a 27 percent reduction in the relative risk of developing AF during the trial period; specifically, AF was reported among 138 participants in the placebo group and 100 in the rosuvastatin group (hazard ratio 0.73, 95% CI 0.56-0.94, p=0.01). This association remained significant after multivariate adjustment (adjusted HR for rosuvastatin 0.72, 95% CI 0.55-0.93, p=0.01) as well as in analyses excluding participants who developed a major cardiovascular event prior to the report of AF (adjusted HR for rosuvastatin 0.74, 95% CI 0.57-0.97, p=0.03). Conclusions: Within the JUPITER trial cohort of individuals selected for underlying inflammation, increasing levels of hs-CRP were associated with an increased risk of incident AF and random allocation to rosuvastatin significantly reduced that risk.
Abstract 16978: Midregional Pro-Atrial Natriuretic Peptide and Risk of Recurrent Cardiovascular Disease Events in Patients with Stable Coronary Heart Disease Followed Over 8 Years
Authors: Mahir Karakas, Wolfgang Koenig, Andrea Kleiner, Hermann Brenner, Dietrich Rothenbacher
Journal: Circulation (2011)

Aim: Natriuretic peptides provide valuble information about cardiac dysfunction. The clinical relevance of elevated circulating midregional pro-atrial natriuretic peptide (MR-proANP) in patients with stable coronary heart disease (CHD) several weeks after an acute event has not been fully evaluated. We aimed to assess the predictive value of MR-proANP for recurrent cardiovascular disease (CVD) events in stable CHD patients, simultaneously controlling for a large number of potential confounders. Methods: Plasma concentrations of MR-proANP (BRAHMS) were measured at baseline in a cohort of 1,048 patients aged 30-70 years with CHD. The Cox proportional hazards model was used to determine the prognostic value of MR-proANP on a combined CVD endpoint after adjustment for covariates. Results: The median MR-proANP level was 135.2 pmol/L (interquartile range 95.2-185.8). Elevated MR-proANP levels were associated with higher age, obesity, history of hypertension, diabetes, and heart failure, higher number of affected vessels, initial management of CHD, and left-ventricular dysfunction in a statistically significant way. Furthermore, after adjustment for age and gender MR-proANP was correlated with CRP (correlation coefficient (R=0.21), NT-proBNP (R=0.72), creatinine clearance (R= -0.32), cystatin C (R=0.43), hsTnT (R= 0.51) respectively (all p-values &lt;0.0001). During a median follow-up of 8.1 years, 150 patients (21.1%) experienced a fatal- or non-fatal secondary CVD event. In a multivariate model MR-proANP was associated with a hazard ratio (HR) of secondary CVD events of 3.00 (95% confidence interval (CI), 1.70-5.28) when extreme quartiles were compared. Further adjustment for NT-proBNP attenuated the association only slightly (HR 2.67; 95% CI, 1.48-4.79). Conclusions: Elevated MR-proANP levels in stable CHD patients are associated with several CVD disorders and predict long-term CVD events in these patients.
Abstract 5728: Abrupt Early Intraventricular Septal Motion In Not Passive But Active In Left Bundle Brunch Block
Authors: Azusa Furugen, Naoki Matsuda, Tsuyoshi Shiga, Daigo Yagishita, Asako Mochida, Kyomi Ashihara, Morio Shoda, Naoko Ishizuka, Nobuhisa Hagiwara
Journal: Circulation (2008)

Abnormal early septal motion observed in patients with left bundle brunch block (LBBB) has been explained as a difference in right-to-left ventricular pressure. The interventricular septum was thought to be displaced passively into the LV because the right ventricle contracts prior to the LV and the right ventricular pressure exceeds the LV pressure during early systolic phase. Assuming that this theory is right, the interventricular septal wall would be stretched and shown positive strain value in circumferential and longitudinal directions during early systolic phase. We investigated the mechanism of the early septal motion with LBBB using speckle tracking imaging (STI). Methods: Systolic septal motion on the middle LV portion level was analyzed in 44 patients with complete LBBB (mean QRS duration 166 ± 35 ms) using M-mode echocardiography and speckle tracking imaging (STI). Time from onset of QRS configuration to peak circumferential strain and longitudinal strain were measured in parasternal short axis and apical views by STI. Furthermore, 20 healthy individuals (mean QRS duration 84 ± 6 ms) were also analyzed. Changes in LV pressure and septal strain were simultaneously measured to evaluate the relationship between them in 6 patients with LBBB. Results: Septal displacement into the LV was early and abrupt on M-mode echocardiograms from all patients with LBBB. During this displacement, the STI of the interventricular septum of all patients showed negative strain in both the circumferential and longitudinal directions. Furthermore, early septal displacement almost coincided with peak negative strain. Time to peak septal strain in LBBB patients was significantly shorter than in normal controls in the circumferential (296 ± 80 vs. 356 ± 30 ms; p &lt; 0.05) and longitudinal (317 ± 104 vs. 369 ± 17 ms; p &lt; 0.05) directions. The peak of septal negative strain was followed by an increase in LV pressure in all patients. Conclusion: Early motion of the interventricular septum is provoked by its active contraction in LBBB. The septal contraction starts very early and almost isotonically toward a very low load. However, further shortening is suppressed by a subsequently increased load of pressure elevation due to the contraction of other LV segments.
DISSECTING ANEURYSM OF THE AORTA WITH PERIPHERAL EMBOLIZATION: A CASE REPORT
Authors: W C SCHRAFT, J R LISA
Journal: Annals of Internal Medicine (1951)

Case Reports1 February 1951DISSECTING ANEURYSM OF THE AORTA WITH PERIPHERAL EMBOLIZATION: A CASE REPORTWILLIAM C. SCHRAFT JR., M.D., JAMES R. LISA, M.D., F.A.C.P.WILLIAM C. SCHRAFT JR., M.D.Search for more papers by this author, JAMES R. LISA, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-2-507 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDissecting aneurysm of the aorta is a fairly common finding at the autopsy table. Its incidence has been reported as approximately one in 400 necropsies. At City Hospital there have been 16 cases autopsied in the past 22 years, a ratio of approximately one in 355 necropsies. Nearly 800 cases have been described in the literature. So far as could be determined, multiple distant embolizations due to mural thrombi located at the site of intimal rupture have not previously been observed. This communication is the report of such a case.CASE REPORTThe patient was a white woman, 64 years...Bibliography1. Erdheim J: (a) Medionecrosis aortae idiopathica, Virchows Arch. f. path. Anat. 273: 454-479, 1929. (b) Medionecrosis aortae idiopathica cystica, Virchows Arch. f. path. Anat. 276: 187-229, 1930. CrossrefGoogle Scholar2. HollandBayley LFRH: Dissecting aneurysm: a report of 19 cases with a review of the recent American literature, Am. Heart J. 20: 223, 1940. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 7, 1949.From the Division of Pathology, City Hospital, Welfare Island, Department of Hospitals, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRepeated Peripheral Embolisms associated with Chronic Aortic DissectionKrankheiten der GefäßeKrankheiten der Gefäße 1 February 1951Volume 34, Issue 2Page: 507-510KeywordsAneurysmsAortaAutopsy pathology ePublished: 1 December 2008 Issue Published: 1 February 1951 PDF downloadLoading ...
Abstract 2275: The Association of Cardiac Catheterization Timing, Contrast Media Amount, and Preoperative Renal Function with Post Cardiac Surgery Acute Renal Failure and Mortality
Authors: Benjamin Medalion, Hilit Cohen, Abid Assali, Eitan Snir, Erez Sharoni, Philip Biderman, Ran Kornowski, Eyal Porat
Journal: Circulation (2008)

Background The effect of cardiac catheterization timing, contrast media dose, and preoperative renal function on post cardiac surgery acute renal failure (ARF) prevalence is unclear. Methods and Results Data of 395 consecutive patients who underwent CABG were prospectively collected. Glomerular filtration rate (eGFR) was estimated by the CockcroftGault equation. Patients were divided into 3 groups according to the time between cardiac catheterization and surgery (Group I:≤1 day, Group II:&gt;1 and ≤5 days, Group III:&gt;5 days). Patients who underwent salvage operation, or were on dialysis before surgery were excluded. Multivariable analysis was used to identify risk factors for ARF (defined as 25% decrease from baseline of eGFR, and eGFR≤60ml/min on postoperative day 3). propensity score analysis was used to adjust differences in preoperative characteristics between groups. ARF developed in 13% of patients. Hospital mortality was 3.3% and was higher in patients who developed ARF (21%) vs those that did not (0.6%, p&lt;0.001). Multivariable analysis identified operation within 24 hours of catheterization (OR=4), and eGFR&lt;60ml/min up to 5 days from catheterization (OR=2.5) as independent predictors of ARF (p&lt;0.05). The use of more than 1.4 ml/kg of contrast media in patients with eGFR&lt;60ml/min predicted ARF as well (OR=5, p&lt;0.001). Older age, lower weight, and lower preoperative hemoglobin levels were also associated with ARF. Conclusions Whenever possible, cardiac surgery should be delayed for at least 24 hours (preferably 5 days) from catheterization, especially in patients with low eGFR, and in those who received high dose of contrast media.