tbuckley/cabot-search huggingface dataset:
PSYCHOSOMATIC ILLNESSES IN URBAN PRACTICE
Authors: R. S. Leadingham
Journal: Annals of Internal Medicine (1943)

Article1 November 1943PSYCHOSOMATIC ILLNESSES IN URBAN PRACTICER. S. LEADINGHAM, M.D., F.A.C.P.R. S. LEADINGHAM, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-5-741 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPsychoneuroses with their attendant autonomic alterations of visceral functions frequently assume the pattern of organic disease and become major problems in identification and management. When they are associated with frank morbid anatomical processes they create confusion in diagnosis and often lessen the effectiveness of therapy. Economically, their significance is not generally recognized, although if valid statistics were available they would rank high among the causes of inefficiency and days lost from employment, to say nothing of the added cost of medical care. One patient for 10 years set aside 50 dollars a month from a small income for medical services,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Atlanta, Georgia*Read before the Fulton County Medical Society, May 4, 1942. Received for publication August 1, 1942.From the department of Medicine, Emory University, School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTo Love and to Kill: Accurate and Selective Colorimetry for Both Chloride and Mercury Ions Regulated by Electro-Synthesized Oxidase-like SnTe Nanobelts 1 November 1943Volume 19, Issue 5Page: 741-748KeywordsMedical servicesPatients ePublished: 1 December 2008 Issue Published: 1 November 1943 PDF downloadLoading ...
Abstract 685: Atherosclerotic Plaque Composition Among patients with Stenotic Coronary Artery Disease on Non Invasive Coronary CT Angiography
Authors: Gudrun Feuchtner, Daniel Jodocy, Ricardo C Cury, Guy Friedrich, Roger S Blumenthal, Matt Budoff, Khurram Nasir
Journal: Circulation (2008)

Coronary CT angiography (CCTA) has emerged as a promising non-invasive tool to rule out significant coronary artery disease (CAD) as well provides additional information about atherosclerotic plaque composition. In this study we aim to assess the whether differences in plaque composition exist across patients with varying degree of stenotic CAD disease. The study population consisted of 548 subjects (58±11 years, 45% women) referred for 64-slice multi-detector CCTA for assessment of underlying degree of coronary artery disease. We analyzed plaque characteristics on a per-segment basis according to the modified AHA classification. Plaques types were classified as non-calcified, calcified, mixed type 1 (predominantly non-calcified) or mixed type 2 (predominantly non-calcified). Overall 194 (35%) had normal coronaries without evidence of plaque. In the remaining 354 patients, 187 (34%) and 167 (31%) were found to have luminal narrowing of &lt;50% and ≥70% in at-least one coronary artery segment, respectively. Those with a higher degree of stenotic CAD demonstrated significantly more coronary segments with exclusively calcified and mixed plaques (table ). Among those with significant CAD, the overall proportion of plaque burden was more likely to be mixed predominantly calcified (18% vs. 38% vs. 44%) as well as mixed predominantly non-calcified in nature; whereas were less likely to be exclusively non-calcified (39% vs. 20% vs. 16%). Only 3/208 (1.3%) patients without any underlying calcification had significant CAD (stenosis ≥50%). In summary, significant differences in plaque composition according to severity of CAD were observed in our study with a higher mixed plaque and lesser non-calcified plaque burden among those with stenotic CAD. These findings should stimulate further investigations to assess the prognostic value of plaque according to their underlying composition.
Analysis of infused donor lymphocytes in leukemia patients who relapsed after allogeneic bone marrow transplantation
Authors: S. Kolen, H. Dolstra, A. Schattenberg, A. Zoetbrood, E. Braakman, A. van de Locht, C.G. Figdor, T. de Witte, E. van de Wiel-van Kemenade
Journal: Blood (1999)
Abstract P023: Resolution of Systemic Hypertension after Bariatric Surgery is Predicted by Sagittal Diameter Decrement and Age
Authors: Audrey Auclair, Julie Martin, Marjorie Bastien, Nadine Bonneville, Marie-Eve Leblanc, Frederic-Simon Hould, Fady Moustarah, Laurent Biertho, Paul Poirier
Journal: Circulation (2013)

Severe obesity is associated with several comorbidities including systemic hypertension. While bariatric surgery is the most effective long term treatment for the management of severe obesity, syst...
Mechanical Sorting of Abstracts
Authors: David Mills
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 August 1975Mechanical Sorting of AbstractsDAVID MILLS, M.D.DAVID MILLS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-2-287 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent correspondence in the Letters section has emphasized the need for a personal filing system for medical literature abstracts (1). The "Annals" and other journals now print separate sets of abstracts to simplify their removal from the bound publication. We report here a simple method of cross-indexing, filing, and retrieval of these abstracts by the use of edge punch cards and a mechanical sorting machine*. These abstracts can be cross-indexed for four different headings and can be sorted for any combination of entries in a few minutes.The abstracts are simply cut out of...Reference1. BAKERBRASHEAR DR: Cross-indexed file for medical literature. Ann Intern Med 80:557-559, 1974 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Littlcomputer, Denver, Colorado. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1975Volume 83, Issue 2Page: 287-288 ePublished: 1 December 2008 Issue Published: 1 August 1975 PDF downloadLoading ...
MEDICAL PROBLEMS IN RADIOLOGICAL DEFENSE
Authors: F R PHILBROOK
Journal: Annals of Internal Medicine (1951)

Article1 November 1951MEDICAL PROBLEMS IN RADIOLOGICAL DEFENSEFRANK R. PHILBROOK, M.D., M.P.H.FRANK R. PHILBROOK, M.D., M.P.H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-5-975 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe need for disaster planning and organization has been exemplified in recent years by such occurrences as the Cocoanut Grove Fire in Boston, the Texas City and Perth Amboy explosions, and other similar holocausts. These taxed medical facilities to the limit, yet the number of casualties involved represents only a small fraction of the number to be expected if a well planned and executed atomic attack were to be successfully launched against one or more large cities of the United States. Saturation bombing of London, the fire-bomb raids on Tokyo and the atomic bombings of Hiroshima and Nagasaki created... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Presented at the Thirty-second Annual Session of the American College of Physicians, St. Louis, Mo., April 10, 1951. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1951Volume 35, Issue 5Page: 975-980 ePublished: 1 December 2008 Issue Published: 1 November 1951 PDF downloadLoading ...
MINIBIKE AND MOTORCYCLE ACCIDENTS IN ADOLESCENTS
Authors: J M Speca, H R Cowell
Journal: JAMA (1975)

Twenty-one adolescents, ranging in age from 9 to 16 years, sustained accidental injuries while operating a minibike, motorcycle, or go-cart. Their injuries ranged from lacerations and contusions to paraplegia and amputation. This study suggests that this new pattern of injury is reaching epidemic levels in this age group.
Abstract 2345: Improving Outcomes in High Risk Tetralogy of Fallot Patients with Right Ventricular Outflow Tract Stenting
Authors: Gaute Dohlen, Rajiv Chaturvedi, Lee N Benson, Deborah Fruitman, Akira Osawa, Kyong-Jin Lee
Journal: Circulation (2007)

Background: Symptomatic infants with tetralogy of Fallot (TOF) and hypoplastic pulmonary arteries have higher risk for primary surgical repair. In our institution, palliation with only balloon angioplasty of the right ventricular outflow tract (RVOT) and pulmonary valve has been inconsistent and short-lived. Objectives: To evaluate our experience with percutaneous transcatheter stent implantation in the RVOT in symptomatic TOF patients. Methods: Retrospective review at the Hospital for Sick Children in Toronto, Canada from 1994 until 2007 (Group I). Outcomes were compared with our institutional primary surgical repair patients (n = 44, Group II). Results: Ten stent procedures performed in 8 patients. Median age at first intervention was 22 days (range, 3 to 119). Median weight was 3.2 kg (2.1 to 4.1). Indication for intervention was desaturation below 70% or prostaglandin dependency. Two patients required a second stenting procedure for progressive RVOT obstruction at 67 and 122 days of life. There were no major procedural complications. Discharge post stent implantation occurred at a median of 4 days (1 to 12). Median number of days from initial stent implantation to next intervention was 108 days (44 to 315). Left and right pulmonary artery diameter Z-score increased from a median of −4.3 and −3.5 to −0.9 and −0.8 respectively before surgery. For Group I and II respectively, surgical data were: repair at median age of 142 days (44 to 413) compared to 24 days (5 to 112) (P&lt;0.001), median weight at surgery 5.3 kg (4.0 to 9.3) and 3.2 kg (2.0 to 5.9) (P&lt;0.001), median bypass time 99 minutes (66 to 127) and 118 minutes (54 to 264) (P=0.03), median ventilator days 4 (0 to 11) and 6 (1 to 97) (P=0.08), median days in intensive care unit was 5 (2 to 12) versus 8 (2 to 161) (P=0.09), time to discharge was 16 days (5 to 29) and 16 days (6 to 230) (P=0.35). There was no mortality in Group I and 2 late hospital deaths in Group II. Conclusion: Stenting of the RVOT in TOF patients safely and effectively palliated symptomatic patients. This promoted development of more favourable pre-operative conditions and translated to excellent surgical outcomes. This approach represents a powerful adjunct to the management armamentarium for this challenging patient population.
Abstract 12702: The Eya4/six1 Signalling Cascade is Crucial in the Development of Heart Disease
Authors: Tatjana Williams, Moritz Hundertmark, Daniela Kraemer, Jost Schonberger, Martin Czolbe, Franziska Panther, Vera Pekarek, Oliver Ritter
Journal: Circulation (2011)

Introduction:  We identified a mutation in the human transcription cofactor Eya4 (E193) to cause terminal heart failure preceded by sensorineural hearing loss. Eya proteins lack DNA-binding and nuclear translocation sequences and therefore must interact with real transcription factors, including Six family members. The cyclin-dependent kinase inhibitor p27kip1 (p27), which inhibits hypertrophic growth in adult cardiomyocytes, is one of the few known Eya-Six targets expressed in the heart. We hypothesize that Eya4/Six1 regulates targets relevant to sustain normal cardiac function via p27.   Methods and results:  We examined the correlation of Eya4 and the mutant E193 overexpression upon p27 in permanent mammalian cell lines and primary cardiac myocytes. Westernblot analysis demonstrated that an overexpression of Eya4 led to a significant suppression of p27, whereas E193 had no effect on p27 levels; knockdown of Eya4 via siRNA exerted opposing effects. Promoter studies using a p27 promoter fragment including Six1 consensus sites revealed that the constitutive suppression of p27 by Eya4 was released after targeting one of the Six1 consensus sites; E193 had no effect on p27 promoter activity. We constructed a transgenic mouse model with a constitutive myocardial overexpression of HA-tagged E193 to study the effect of a disturbed Eya4/Six1 complex upon cardiac physiology. Magnetic resonance imaging to visualize cardiac structures in detail along with hemodynamic measurements showed that an overexpression of E193 in mice leads to an age related onset of cardiomyopathy similar to patients carrying the E193 mutation. HE-stainings show dilation of the LV associated with a thinning of the myocardial wall. PSR-stainings show interstitial fibrosis of the myocardial tissue which is characteristic for cardiac disease.   Conclusion:  In summary, we identified a mutation in Eya4 to cause DCM. Eya4/Six1 seems to suppress the expression of p27, an important inhibitor of the development of hypertrophy in postmitotic cardiomyocytes. Our transgenic mouse model with overexpression of the Eya4 mutant E193 supports our hypothesis whereas the dysfunctional E193 mutant could not suppress p27, finally leading to an age related onset of cardiomyopathy.
Abstract 14649: C57BL/6 Nk Cell Gene Complex Crucially Involved in Vascular Remodeling and Intimal Hyperplasia
Authors: Margreet R de Vries, Leonard Seghers, Jeroen van Bergen, Rene E Toes, Paul H Quax
Journal: Circulation (2011)

Introduction Immune cells as monocytes, CD4+ and CD8+ T-cells but also NK-cells are proven contributors to atherosclerosis and vascular remodelling. Interestingly, C57BL/6 mice display profound ind...
Cell implants reconstruct myelin sheaths
Authors: Lisa Melton
Journal: BMJ (1999)

Scientists have succeeded in remyelinating damaged areas of the central nervous system and restoring lost function by transplanting glial cells directly into the spinal cord of animals.

This reconstruction feat, until recently thought impossible, raises hopes of finding treatments for diseases with persistent myelin loss, such as multiple sclerosis and the leucodystrophies.

Bill Blakemore, professor of neuropathology at the University of Cambridge, told neuroscientists at a Novartis Foundation symposium in London last week, that his team had identified the cells with the greatest capacity to make myelin sheaths.

Grafting cells into lesions to replace the lost function seems to be a safe approach. Clinical experience with transplants …
Schizophrenia-related and affective personality disorder traits in relatives of probands with schizophrenia and personality disorders
Authors: J M Silverman, L J Siever, T B Horvath, E F Coccaro, H Klar, M Davidson, L Pinkham, S H Apter, R C Mohs, K L Davis
Journal: American Journal of Psychiatry (1993)

The possible heterogeneity of the schizophrenia-related personality disorder traits associated with DSM-III criteria for schizotypal personality disorder was investigated using the family history method. A familial relationship to schizophrenia was hypothesized for schizophrenia-related personality disorder traits without coexisting affective personality disorder traits, pure schizophrenia-related personality disorder traits. Alternatively, a familial relationship with borderline personality disorder was hypothesized for schizophrenia-related personality disorder traits with comorbid affective personality disorder traits.Criteria for schizophrenia-related and affective personality disorder traits were used to assess the 588 nonpsychotic first-degree relatives of 55 chronic schizophrenic probands and 67 probands with personality disorders. The probands with one or more DSM-III personality disorders were categorized as having schizotypal personality disorder without borderline personality disorder (pure schizotypal personality disorder), borderline personality disorder without schizotypal personality disorder (pure borderline personality disorder), both disorders, or neither.The morbid risk of all cases of schizophrenia-related personality disorder traits was higher in relatives of probands with schizophrenia and pure schizotypal personality disorder than in relatives of probands with neither schizotypal nor borderline personality disorder; however, it differed only slightly from that observed in the relatives of probands with both schizotypal and borderline personality disorders and pure borderline personality disorder. In contrast, the risk of pure schizophrenia-related personality disorder traits was higher in relatives of probands with schizophrenia and pure schizotypal personality disorder, while the risk of coexisting schizophrenia-related and affective personality disorder traits was lower in both of these groups than among the relatives of probands with both schizotypal and borderline personality disorders and pure borderline personality disorder.These results offer preliminary indications that schizotypal personality disorder features present without comorbid affective personality disorder traits may more specifically characterize the personality characteristics familially related to schizophrenia. Furthermore, they indicate that schizotypal personality disorder features as currently defined are found in relatives of patients other than those with schizophrenia or schizotypal personality disorder.
Abstract P4-11-32: Routine histopathological variables predict oncotype DX risk categories
Authors: Hidetaka Kawabata, Keiichi Kinowaki, Nobuko Tamura, Yoko Kobayashi, Masami Kadowaki, Daishu Miura, Toshimi Takano, Akihiko Shimomura, Tsuguo Iwatani, Yuko Kitawaki, Takeshi Fujii
Journal: Cancer Research (2015)

Abstract Background: Oncotype DX(ODX) is a clinically validated, commercially available multi-gene assay that provides prognostic and predictive information in estrogen receptor(ER)-positive, Her2-negative breast cancer. Because health care system does not cover this expensive assay in many countries, physicians and researchers try to use routine histopathological variables predict ODX Recurrence Score (RS). Hyunseok Kim et.al presented at ASCO that Estimated Recurrence Score (ERS) model could identify those patients most likely to benefit from including ODX RS results in therapeutic decision-making (J Clin Oncol 32:5s, 2014 suppl; abstr 559). Methods: We retrospectively reviewed histopathological slides between July 2007 and April 2014 from Toranomon Hospital patients (n=149) with early stage ER-positive, Her2-negative breast cancer, for whom ODX was ordered. We developed an original linear regression model using routine histopathological markers (Allred Score for progesterone receptor (PR), nuclear grade(NG), and Ki67) to calculate an Estimated Recurrence Score (ERS), and correlated it with the observed ODX RS assay result. ERS=20.46+0.298xKi67–1.48xPR+1.41xNG predicts the ODX RS with an R2 of 0.48. In order to internally validate this model in the Toranomon Hospital cohort in Japan, we adapted Hyunseok’s algorithm. Results: 132 patients had an observed RS ≤ 25 (89%) and 17 patients had an observed RS above 25 (11%). When the ERS was &amp;lt; 21 (n=124), we accurately classified 97% of them (120) who were found to have a low risk (observed RS ≤ 25). Similarly, 83% of those (5/6) with an ERS &amp;gt; 30 fell into a high risk category with observed RS &amp;gt; 25. Table1 (TAILORx risk categories)Toranomon cohortODX ≤25ODX RS&amp;gt;25TotalERS &amp;lt; 211204124ERS(21-30)11819ERS(&amp;gt; 30)156Total13217149 We also presented the comparison of ERS and observed RS based on original risk categories. Table2 (Original risk categories )Toranomon cohortODX RS&amp;lt;18ODX RS 18-30ODX RS&amp;gt;30TotalERS(&amp;lt;18)6633099ERS(18-30)1725244ERS(&amp;gt;30)0156Total83597149 Conclusions: We developed an ERS model to find those patients most likely to benefit from ODX RS results in clinical practice setting. Although further external and prospective validation is mandatory, preliminary result supports the usefulness of this ERS model. Citation Format: Hidetaka Kawabata, Keiichi Kinowaki, Nobuko Tamura, Yoko Kobayashi, Masami Kadowaki, Daishu Miura, Toshimi Takano, Akihiko Shimomura, Tsuguo Iwatani, Yuko Kitawaki, Takeshi Fujii. Routine histopathological variables predict oncotype DX risk categories [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-11-32.
Glia–neuron interactions in the mammalian retina
Authors: Elena Vecino, F.David Rodriguez, Noelia Ruzafa, Xandra Pereiro, Sansar C. Sharma
Journal: Progress in Retinal and Eye Research (2015)

The mammalian retina provides an excellent opportunity to study glia–neuron interactions and the interactions of glia with blood vessels. Three main types of glial cells are found in the mammalian retina that serve to maintain retinal homeostasis: astrocytes, Müller cells and resident microglia. Müller cells, astrocytes and microglia not only provide structural support but they are also involved in metabolism, the phagocytosis of neuronal debris, the release of certain transmitters and trophic factors and K+ uptake. Astrocytes are mostly located in the nerve fibre layer and they accompany the blood vessels in the inner nuclear layer. Indeed, like Müller cells, astrocytic processes cover the blood vessels forming the retinal blood barrier and they fulfil a significant role in ion homeostasis. Among other activities, microglia can be stimulated to fulfil a macrophage function, as well as to interact with other glial cells and neurons by secreting growth factors. This review summarizes the main functional relationships between retinal glial cells and neurons, presenting a general picture of the retina recently modified based on experimental observations. The preferential involvement of the distinct glia cells in terms of the activity in the retina is discussed, for example, while Müller cells may serve as progenitors of retinal neurons, astrocytes and microglia are responsible for synaptic pruning. Since different types of glia participate together in certain activities in the retina, it is imperative to explore the order of redundancy and to explore the heterogeneity among these cells. Recent studies revealed the association of glia cell heterogeneity with specific functions. Finally, the neuroprotective effects of glia on photoreceptors and ganglion cells under normal and adverse conditions will also be explored.