tbuckley/cabot-search huggingface dataset:
MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer
Authors: Jitendra K. Meena, Jarey H. Wang, Nicholas J. Neill, Dianne Keough, Nagireddy Putluri, Panagiotis Katsonis, Amanda M. Koire, Hyemin Lee, Elizabeth A. Bowling, Siddhartha Tyagi, Mayra Orellana, Rocio Dominguez-Vidaña, Heyuan Li, Kenneth Eagle, Charles Danan, Hsiang-Ching Chung, Andrew D. Yang, William Wu, Sarah J. Kurley, Brian M. Ho, Joseph R. Zoeller, Calla M. Olson, Kristen L. Meerbrey, Olivier Lichtarge, Arun Sreekumar, Clifford C. Dacso, Luke W. Guddat, Dominik Rejman, Dana Hocková, Zlatko Janeba, Lukas M. Simon, Charles Y. Lin, Monica C. Pillon, Thomas F. Westbrook
Journal: Cancer Discovery (2024)

Abstract Upregulation of MYC is a hallmark of cancer, wherein MYC drives oncogenic gene expression and elevates total RNA synthesis across cancer cell transcriptomes. Although this transcriptional anabolism fuels cancer growth and survival, the consequences and metabolic stresses induced by excess cellular RNA are poorly understood. Herein, we discover that RNA degradation and downstream ribonucleotide catabolism is a novel mechanism of MYC-induced cancer cell death. Combining genetics and metabolomics, we find that MYC increases RNA decay through the cytoplasmic exosome, resulting in the accumulation of cytotoxic RNA catabolites and reactive oxygen species. Notably, tumor-derived exosome mutations abrogate MYC-induced cell death, suggesting excess RNA decay may be toxic to human cancers. In agreement, purine salvage acts as a compensatory pathway that mitigates MYC-induced ribonucleotide catabolism, and inhibitors of purine salvage impair MYC+ tumor progression. Together, these data suggest that MYC-induced RNA decay is an oncogenic stress that can be exploited therapeutically. Significance: MYC is the most common oncogenic driver of poor-prognosis cancers but has been recalcitrant to therapeutic inhibition. We discovered a new vulnerability in MYC+ cancer where MYC induces cell death through excess RNA decay. Therapeutics that exacerbate downstream ribonucleotide catabolism provide a therapeutically tractable approach to TNBC (Triple-negative Breast Cancer) and other MYC-driven cancers.
Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors
Authors: Yingjie Zhu, Xin Pei, Ardijana Novaj, Jeremy Setton, Daniel Bronder, Fatemeh Derakhshan, Pier Selenica, Niamh McDermott, Mehmet Orman, Sarina Plum, Shyamal Subramanyan, Sara H. Braverman, Biko McMillan, Sonali Sinha, Jennifer Ma, Andrea Gazzo, Atif Khan, Samuel Bakhoum, Simon N. Powell, Jorge S. Reis-Filho, Nadeem Riaz
Journal: Genome Medicine (2024)

Abstract Background Pathogenic BRCA1 or BRCA2 germline mutations contribute to hereditary breast, ovarian, prostate, and pancreatic cancer. Paradoxically, bi-allelic inactivation of BRCA1 or BRCA2 (bBRCA1/2) is embryonically lethal and decreases cellular proliferation . The compensatory mechanisms that facilitate oncogenesis in bBRCA1/2 tumors remain unclear. Methods We identified recurrent genetic alterations enriched in human bBRCA1/2 tumors and experimentally validated if these improved proliferation in cellular models. We analyzed mutations and copy number alterations (CNAs) in bBRCA1/2 breast and ovarian cancer from the TCGA and ICGC. We used Fisher’s exact test to identify CNAs enriched in bBRCA1/2 tumors compared to control tumors that lacked evidence of homologous recombination deficiency. Genes located in CNA regions enriched in bBRCA1/2 tumors were further screened by gene expression and their effects on proliferation in genome-wide CRISPR/Cas9 screens. A set of candidate genes was functionally validated with in vitro clonogenic survival and functional assays to validate their influence on proliferation in the setting of bBRCA1/2 mutations. Results We found that bBRCA1/2 tumors harbor recurrent large-scale genomic deletions significantly more frequently than histologically matched controls ( n = 238 cytobands in breast and ovarian cancers). Within the deleted regions, we identified 277 BRCA1-related genes and 218 BRCA2-related genes that had reduced expression and increased proliferation in bBRCA1/2 but not in wild-type cells in genome-wide CRISPR screens. In vitro validation of 20 candidate genes with clonogenic proliferation assays validated 9 genes, including RIC8A and ATMIN (ATM-Interacting protein). We identified loss of RIC8A , which occurs frequently in both bBRCA1/2 tumors and is synthetically viable with loss of both BRCA1 and BRCA2 . Furthermore, we found that metastatic homologous recombination deficient cancers acquire loss-of-function mutations in RIC8A . Lastly, we identified that RIC8A does not rescue homologous recombination deficiency but may influence mitosis in bBRCA1/2 tumors, potentially leading to increased micronuclei formation. Conclusions This study provides a means to solve the tumor suppressor paradox by identifying synthetic viability interactions and causal driver genes affected by large-scale CNAs in human cancers.
Diabetes, Prediabetes, and Brain Aging: The Role of Healthy Lifestyle
Authors: Abigail Dove, Jiao Wang, Huijie Huang, Michelle M. Dunk, Sakura Sakakibara, Marc Guitart-Masip, Goran Papenberg, Weili Xu
Journal: Diabetes Care (2024)

OBJECTIVE Diabetes is a well-known risk factor for dementia. We investigated the association between (pre)diabetes and older brain age and whether this can be attenuated by modifiable lifestyle behaviors. RESEARCH DESIGN AND METHODS The study included 31,229 dementia-free adults from the UK Biobank between the ages of 40 and 70 years. Glycemic status (normoglycemia, prediabetes, or diabetes) was ascertained based on medical history, medication use, and HbA1c measured at baseline. Information on cardiometabolic risk factors (obesity, hypertension, low HDL, and high triglycerides) and lifestyle behaviors (smoking, drinking, and physical activity) was also collected at baseline. Participants underwent up to two brain MRI scans over 11 years of follow-up. Brain age was estimated using a machine learning model based on 1,079 brain MRI phenotypes and used to calculate brain age gap (BAG; i.e., brain age minus chronological age). RESULTS At baseline, 13,518 participants (43.3%) had prediabetes and 1,149 (3.7%) had diabetes. Prediabetes (β = 0.22 [95% CI 0.10, 0.34]) and diabetes (2.01 [1.70, 2.32]) were both associated with significantly higher BAG, and diabetes was further associated with significant increase in BAG over time (0.27 [0.01, 0.53]). The association between (pre)diabetes and higher BAG was more pronounced in men and in people with two or more cardiometabolic risk factors. In joint exposure analysis, having a healthy lifestyle (i.e., no smoking, no heavy drinking, and high physical activity) significantly attenuated the diabetes-BAG association. CONCLUSIONS Diabetes and even prediabetes are associated with accelerated brain aging, especially among men and people with poor cardiometabolic health. However, a healthy lifestyle may counteract this.
Health and economic impacts of Lassa vaccination campaigns in West Africa
Authors: David R M Smith, Joanne Turner, Patrick Fahr, Lauren A Attfield, Paul R Bessell, Christl A Donnelly, Rory Gibb, Kate E Jones, David W Redding, Danny Asogun, Oladele Oluwafemi Ayodeji, Benedict N Azuogu, William A Fischer, Kamji Jan, Adebola T Olayinka, David A Wohl, Andrew A Torkelson, Katelyn A Dinkel, Emily J Nixon, Koen B Pouwels, T Déirdre Hollingsworth
Journal: Nature Medicine (2024)

Abstract Lassa fever is a zoonotic disease identified by the World Health Organization (WHO) as having pandemic potential. This study estimates the health-economic burden of Lassa fever throughout West Africa and projects impacts of a series of vaccination campaigns. We also model the emergence of ‘Lassa-X’—a hypothetical pandemic Lassa virus variant—and project impacts of achieving 100 Days Mission vaccination targets. Our model predicted 2.7 million (95% uncertainty interval: 2.1–3.4 million) Lassa virus infections annually, resulting over 10 years in 2.0 million (793,800–3.9 million) disability-adjusted life years (DALYs). The most effective vaccination strategy was a population-wide preventive campaign primarily targeting WHO-classified ‘endemic’ districts. Under conservative vaccine efficacy assumptions, this campaign averted $20.1 million ($8.2–$39.0 million) in lost DALY value and $128.2 million ($67.2–$231.9 million) in societal costs (2021 international dollars ($)). Reactive vaccination in response to local outbreaks averted just one-tenth the health-economic burden of preventive campaigns. In the event of Lassa-X emerging, spreading throughout West Africa and causing approximately 1.2 million DALYs within 2 years, 100 Days Mission vaccination averted 22% of DALYs given a vaccine 70% effective against disease and 74% of DALYs given a vaccine 70% effective against both infection and disease. These findings suggest how vaccination could alleviate Lassa fever’s burden and assist in pandemic preparedness.
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity
Authors: Dominik Soll, Chang-Feng Chu, Shan Sun, Veronika Lutz, Mahima Arunkumar, Mariam Gachechiladze, Sascha Schäuble, Maha Alissa-Alkhalaf, Trang Nguyen, Michelle-Amirah Khalil, Ignacio Garcia-Ribelles, Michael Mueller, Katrin Buder, Bernhard Michalke, Gianni Panagiotou, Kai Ziegler-Martin, Pascal Benz, Philipp Schatzlmaier, Karsten Hiller, Hannes Stockinger, Maik Luu, Kilian Schober, Carolin Moosmann, Wolfgang W. Schamel, Magdalena Huber, Christina E. Zielinski
Journal: Nature Immunology (2024)

Abstract The efficacy of antitumor immunity is associated with the metabolic state of cytotoxic T cells, which is sensitive to the tumor microenvironment. Whether ionic signals affect adaptive antitumor immune responses is unclear. In the present study, we show that there is an enrichment of sodium in solid tumors from patients with breast cancer. Sodium chloride (NaCl) enhances the activation state and effector functions of human CD8 + T cells, which is associated with enhanced metabolic fitness. These NaCl-induced effects translate into increased tumor cell killing in vitro and in vivo. Mechanistically, NaCl-induced changes in CD8 + T cells are linked to sodium-induced upregulation of Na + /K + -ATPase activity, followed by membrane hyperpolarization, which magnifies the electromotive force for T cell receptor (TCR)-induced calcium influx and downstream TCR signaling. We therefore propose that NaCl is a positive regulator of acute antitumor immunity that might be modulated for ex vivo conditioning of therapeutic T cells, such as CAR T cells.
Phase separation of phospho-HDAC6 drives aberrant chromatin architecture in triple-negative breast cancer
Authors: Bing Lu, Ru Qiu, Jiatian Wei, Li Wang, Qinkai Zhang, Mingsen Li, Xiudan Zhan, Jian Chen, I-Yun Hsieh, Ciqiu Yang, Jing Zhang, Zicheng Sun, Yifan Zhu, Tao Jiang, Han Zhu, Jie Li, Wei Zhao
Journal: Nature Cancer (2024)
Activity of nested neural circuits drives different courtship songs in Drosophila
Authors: Hiroshi M. Shiozaki, Kaiyu Wang, Joshua L. Lillvis, Min Xu, Barry J. Dickson, David L. Stern
Journal: Nature Neuroscience (2024)

Abstract Motor systems implement diverse motor programs to pattern behavioral sequences, yet how different motor actions are controlled on a moment-by-moment basis remains unclear. Here, we investigated the neural circuit mechanisms underlying the control of distinct courtship songs in Drosophila . Courting males rapidly alternate between two types of song: pulse and sine. By recording calcium signals in the ventral nerve cord in singing flies, we found that one neural population is active during both songs, whereas an expanded neural population, which includes neurons from the first population, is active during pulse song. Brain recordings showed that this nested activation pattern is present in two descending pathways required for singing. Connectomic analysis reveals that these two descending pathways provide structured input to ventral nerve cord neurons in a manner consistent with their activation patterns. These results suggest that nested premotor circuit activity, directed by distinct descending signals, enables rapid switching between motor actions.
Attenuated effector T cells are linked to control of chronic HBV infection
Authors: Kathrin Heim, None Sagar, Özlem Sogukpinar, Sian Llewellyn-Lacey, David A. Price, Florian Emmerich, Anke R. M. Kraft, Markus Cornberg, Sophie Kielbassa, Percy Knolle, Dirk Wohlleber, Bertram Bengsch, Tobias Boettler, Christoph Neumann-Haefelin, Robert Thimme, Maike Hofmann
Journal: Nature Immunology (2024)

Hepatitis B virus (HBV)-specific CD8
NaCl enhances CD8+ T cell effector functions in cancer immunotherapy
Authors: Caterina Scirgolea, Rosa Sottile, Marco De Luca, Alberto Susana, Silvia Carnevale, Simone Puccio, Valentina Ferrari, Veronica Lise, Giorgia Contarini, Alice Scarpa, Eloise Scamardella, Simona Feno, Chiara Camisaschi, Gabriele De Simone, Gianluca Basso, Desiree Giuliano, Emilia Maria Cristina Mazza, Luca Gattinoni, Rahul Roychoudhuri, Emanuele Voulaz, Diletta Di Mitri, Matteo Simonelli, Agnese Losurdo, Davide Pozzi, Carlson Tsui, Axel Kallies, Sara Timo, Giuseppe Martano, Elettra Barberis, Marcello Manfredi, Maria Rescigno, Sebastien Jaillon, Enrico Lugli
Journal: Nature Immunology (2024)
Nanoscale Octopus Guiding Telomere Entanglement: An Innovative Strategy for Inducing Apoptosis in Cancer Cells
Authors: Xiuping Cao, Liyang Fang, Yifan Jiang, Tao Zeng, Shiyan Bai, Shiqing Li, Yana Liu, Wukun Zhong, Chunhua Lu, Huanghao Yang
Journal: Biomaterials (2024)
B-cell intrinsic RANK signaling cooperates with TCL1 to induce lineage-dependent B-cell transformation
Authors: Lisa Pfeuffer, Viola Siegert, Julia Frede, Leonie Rieger, Riccardo Trozzo, Niklas de Andrade Krätzig, Sandra Ring, Shamim Sarhadi, Nicole Beck, Stefan Niedermeier, Mar Abril-Gil, Mohamed Elbahloul, Marianne Remke, Katja Steiger, Ruth Eichner, Julia Jellusova, Roland Rad, Florian Bassermann, Christof Winter, Jürgen Ruland, Maike Buchner
Journal: Blood Cancer Journal (2024)

B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), remain incurable, with MM particularly prone to relapse. Our study introduces a novel mouse model with active RANK signaling and the TCL1 oncogene, displaying both CLL and MM phenotypes. In younger mice, TCL1 and RANK expression expands CLL-like B1-lymphocytes, while MM originates from B2-cells, becoming predominant in later stages and leading to severe disease progression and mortality. The induced MM mimics human disease, exhibiting features like clonal plasma cell expansion, paraproteinemia, anemia, and kidney and bone failure, as well as critical immunosurveillance strategies that promote a tumor-supportive microenvironment. This research elucidates the differential impacts of RANK activation in B1- and B2-cells and underscores the distinct roles of single versus combined oncogenes in B-cell malignancies. We also demonstrate that human MM cells express RANK and that inhibiting RANK signaling can reduce MM progression in a xenotransplantation model. Our study provides a rationale for further investigating the effects of RANK signaling in B-cell transformation and the shaping of a tumor-promoting microenvironment.
Quantifying benefit and harm of extracorporeal life support in cardiogenic shock complicating acute myocardial infarction
Authors: Christian Jung, Bernhard Wernly, Malte Kelm, Uwe Zeymer, Holger Thiele, Raphael Bruno, Anne Freund, Janine Pöss, Steffen Desch, Steffen Schneider, Ibrahim Akin, Tobias Schupp, Janine Pöss, Tienush Rassaf, Ralf Lehmann, Ingo Eitel, Carsten Skurk, Peter Clemmensen, Marcus Hennersdorf, Ingo Voigt, Axel Linke, Eike Tigges, Peter Nordbeck, Raphael Bruno, Philipp Lauten, Hans-Josef Feistritzer, Maria Buske, Steffen Schneider, Daniel Duerschmied, Steffen Desch, Anne Freund, Ibrahim Akin
Journal: Intensive Care Medicine (2024)
Gut microbiota contributes to high-altitude hypoxia acclimatization of human populations
Authors: Qian Su, Dao-Hua Zhuang, Yu-Chun Li, Yu Chen, Xia-Yan Wang, Ming-Xia Ge, Ting-Yue Xue, Qi-Yuan Zhang, Xin-Yuan Liu, Fan-Qian Yin, Yi-Ming Han, Zong-Liang Gao, Long Zhao, Yong-Xuan Li, Meng-Jiao Lv, Li-Qin Yang, Tian-Rui Xia, Yong-Jun Luo, Zhigang Zhang, Qing-Peng Kong
Journal: Genome biology (2024)

The relationship between human gut microbiota and high-altitude hypoxia acclimatization remains highly controversial. This stems primarily from uncertainties regarding both the potential temporal changes in the microbiota under such conditions and the existence of any dominant or core bacteria that may assist in host acclimatization.
The right heart in patients with cancer. A scientific statement of the Heart Failure Association (<scp>HFA</scp>) of the <scp>ESC</scp> and the <scp>ESC Council</scp> of Cardio‐Oncology
Authors: Kalliopi Keramida, Dimitrios Farmakis, Amina Rakisheva, Carlo Gabriele Tocchetti, Pietro Ameri, Riccardo Asteggiano, Ana Barac, Jeroen Bax, Antoni Bayes‐Genis, Jutta Bergler Klein, Chiara Bucciarelli‐Ducci, Jelena Celutkiene, Andrew J.S. Coats, Alain Cohen Solal, Susan Dent, Gerasimos Filippatos, Arjun Ghosh, Joerg Hermann, Yvonne Koop, Daniel Lenihan, Teresa Lopez Fernandez, Alexander R. Lyon, Valentina Mercurio, Brenda Moura, Massimo Piepoli, Yusuf Ziya Sener, Thomas Suter, Aaron L. Sverdlov, Marijana Tadic, Thomas Thum, Peter van der Meer, Sophie van Linthout, Marco Metra, Giuseppe Rosano
Journal: European Journal of Heart Failure (2024)
NERD-seq: a novel approach of Nanopore direct RNA sequencing that expands representation of non-coding RNAs
Authors: Luke Saville, Li Wu, Jemaneh Habtewold, Yubo Cheng, Babita Gollen, Liam Mitchell, Matthew Stuart-Edwards, Travis Haight, Majid Mohajerani, Athanasios Zovoilis
Journal: Genome biology (2024)

Abstract Non-coding RNAs (ncRNAs) are frequently documented RNA modification substrates. Nanopore Technologies enables the direct sequencing of RNAs and the detection of modified nucleobases. Ordinarily, direct RNA sequencing uses polyadenylation selection, studying primarily mRNA gene expression. Here, we present NERD-seq, which enables detection of multiple non-coding RNAs, excluded by the standard approach, alongside natively polyadenylated transcripts. Using neural tissues as a proof of principle, we show that NERD-seq expands representation of frequently modified non-coding RNAs, such as snoRNAs, snRNAs, scRNAs, srpRNAs, tRNAs, and rRFs. NERD-seq represents an RNA-seq approach to simultaneously study mRNA and ncRNA epitranscriptomes in brain tissues and beyond.
Synergism of Fusobacterium periodonticum and N-nitrosamines promote the formation of EMT subtypes in ESCC by modulating Wnt3a palmitoylation
Authors: Mingjun Sun, Zhenyan Peng, Weitao Shen, Xinxin Guo, Yinghao Liao, Yang Huang, Ping Ye, Mohan Hu, Qiang Lin, Ran Liu
Journal: Gut Microbes (2024)

N-Nitrosamine disinfection by-products (NAs-DBPs) have been well proven for its role in esophageal carcinogenesis. However, the role of intratumoral microorganisms in esophageal squamous cell carcinoma (ESCC) has not yet been well explored in the context of exposure to NAs-DBPs. Here, the multi-omics integration reveals
Dynamic evolution of tricuspid regurgitation during hospitalization in patients with acute decompensated heart failure
Authors: Eugenio Zocca, Daniele Cocianni, Davide Barbisan, Maria Perotto, Stefano Contessi, Jacopo Giulio Rizzi, Giulio Savonitto, Enrico Brollo, Elisa Soranzo, Antonio De Luca, Marco Merlo, Gianfranco Sinagra, Davide Stolfo
Journal: European Journal of Heart Failure (2024)
The clinical impact of acquired von Willebrand syndrome secondary to Waldenström macroglobulinemia: an underrecognized source of major bleeding events
Authors: Karan L. Chohan, Rajiv K. Pruthi, Saurabh Zanwar, Jonas Paludo, Ronald Go, Animesh Pardanani, Aneel Ashrani, Joselle M. Cook, Carrie A. Thompson, Asher Chanan-Khan, Sikander Ailawadhi, Thomas M. Habermann, Thomas E. Witzig, Morie A. Gertz, David Dingli, Fransis K. Buadi, Angela Dispenzieri, Nelson Leung, Shaji K. Kumar, Vincent Rajkumar, William L. Nichols, Robert A. Kyle, Stephen M. Ansell, Prashant Kapoor, Meera Sridharan, Jithma P. Abeykoon
Journal: Leukemia (2024)
Nirmatrelvir/ritonavir treatment and risk for postacute sequelae of COVID-19 in older Singaporeans
Authors: Liang En Wee, Jue Tao Lim, An Ting Tay, Calvin J. Chiew, Barnaby Edward Young, Betty Wong, Ruth Lim, Ching Li Lee, Joyce Tan, Shawn Vasoo, David Chien Lye, Kelvin Bryan Tan
Journal: Clinical Microbiology and Infection (2024)
O-PRESS: Boosting OCT axial resolution with Prior guidance, Recurrence, and Equivariant Self-Supervision
Authors: Kaiyan Li, Jingyuan Yang, Wenxuan Liang, Xingde Li, Chenxi Zhang, Lulu Chen, Chan Wu, Xiao Zhang, Zhiyan Xu, Yueling Wang, Lihui Meng, Yue Zhang, Youxin Chen, S Kevin Zhou
Journal: Medical Image Analysis (2024)
Maternal allergy‐preventive diet index, offspring infant diet diversity, and childhood allergic diseases
Authors: Carina Venter, Kaci Pickett‐Nairne, Donald Leung, David Fleischer, Liam O'Mahony, Deborah H. Glueck, Dana Dabelea
Journal: Allergy (2024)

Studies of childhood diet diversity and allergic disease have not examined additional associations with an offspring allergy-linked maternal diet index during pregnancy. We studied both associations in a pre-birth cohort.
FDG PET/MRI in a Case of Isolated Abdominal Incisional Site Metastasis After Laparoscopic Surgery for Colon Cancer
Authors: Xia Ji, Aisheng Dong, Yang Wang, Changjing Zuo
Journal: Clinical Nuclear Medicine (2024)

Abdominal-wall metastasis following laparoscopic surgery for colorectal cancer is rare. We describe FDG PET/MRI findings in a case of isolated abdominal incisional site metastasis after laparoscopic surgery for colon cancer. The abdominal-wall metastasis showed slight hyperintensity on T2-weighted fat-suppressed image and intense focal FDG uptake on PET. This case demonstrates the usefulness of FDG PET/MRI in detecting the atypical metastasis from colon cancer.
Elevated 131I Activity in Adrenal Cyst in a Patient With Thyroid Cancer
Authors: Wei Liu, Xiao Yang, Weidong Gong, Jianqiang Wang, Xueyuan Fan
Journal: Clinical Nuclear Medicine (2024)

A 23-year-old man with papillary thyroid cancer underwent radioiodine ( 131 I) treatment following total thyroidectomy and node dissection. Posttreatment 131 I SPECT/CT images revealed an additional focus of increased 131 I activity in the left adrenal gland, raising suspicion for possible adrenal metastasis. Ultimately, pathological examination confirmed the diagnosis of an adrenal cyst.
Nivolumab and Cabozantinib Immunotherapy Induced Thyroid Dysfunction Detected on 18F-FDG PET/CT in Renal Cell Carcinoma
Authors: Moulish Reddy, Mudalsha Ravina, Harish Goyal, Amit Kumar, Rutuja Kote
Journal: Clinical Nuclear Medicine (2024)

Targeted immunotherapy became the most advanced approach for cancer treatment. Programmed death-1 (PD-1) expressed on activated T cells can reverse immune suppression and cause T-cell activation. Nivolumab, a PD-1 immune checkpoint inhibitor antibody that is a fully human immunoglobulin G4, blocks PD-1 and promotes antitumor immunity. Cabozantinib (tyrosine kinase inhibitor) inhibits the tyrosine kinase activity of vascular endothelial growth factor receptors 1, 2, and 3. As a result of enhancing immune response in normal tissues, immune-related adverse events can occur. Thyroid dysfunction is a common form of immune-related adverse event and seen on 18 F-FDG PET/CT scans post therapy.
68Ga-FAPI-04 PET/CT Imaging in a Patient With Psoriatic Arthritis
Authors: Zitong Zhang, Lixiang Yang, Lisha Jiang, Rong Tian, Qianrui Li
Journal: Clinical Nuclear Medicine (2024)

We described the findings of 68 Ga-FAPI-04 PET/CT of psoriatic arthritis in a 56-year-old man. Intense FAPI uptake was observed alongside the spine and in the joints of bilateral feet and the right hip. 68 Ga-FAPI PET/CT is potentially valuable for the evaluation of join involvement and disease activity in patients with psoriasis.