tbuckley/cabot-search huggingface dataset:
Abstract 17449: PACT: Preventable Admission Care Team: A Unique Approach to Reducing 30 Day Readmissions
Authors: Maria Basso Lipani, Susan R Bernstein, James Stulman, Doran Ricks, Claudia Colgan, Ira Nash, Jill Kalman
Journal: Circulation (2011)

Background/Significance: There is a national mandate to prevent hospital readmissions. In 2009, CMS began publicly reporting 30-day readmission rates for patients hospitalized with pneumonia, acute myocardial infarction, and heart failure. Multiple factors contribute to avoidable readmissions, and can result from: poor quality care, premature discharges, poor coordination and communication between patient and providers. Program: Mount Sinai Hospital (MSH) has created The PACT Program, with the goal of reducing 30 day readmissions. PACT is internally funded and consists of 4 social workers (SW) in the hospital and 2 NP's and 1 SW in the internal medicine clinic. Patients at high risk of readmission are identified in the hospital based on their readmission history. The SW performs a 75 minute patient/caregiver psychosocial assessment. A five week post-discharge care coordination plan follows by the same enrolling SW. This includes intensive phone follow-up and home visits to appraise home safety, environmental hazards, family involvement, medication compliance, nutritional/dietary assessments. Patients with fragmented primary care are referred to the PACT clinic. Patient Profile: Age range from 19-99; 52% are 65+; 8% 85+; 52% women; 48% male; 38% are African-American; 32% Hispanic; 43% have congestive heart failure, 45% diabetes; 16% dialysis, 21% documented mental illness; 66% greater than 2 co-morbidities; 85% Medicare and/or Medicaid; 87% have a family caregiver. Results: 6 month (see table) Conclusions: PACT is engaging the most challenging patients and is successful in reducing 30,60,90 day readmissions. PACT patients represent a diversity of age, gender and ethnicity, are medically complex, enriched in cardiovascular disease and diabetes. PACT includes non-english speaking patients with cognitive impairment, mental illness, which other transitional programs have excluded. The model is replicable, sustainable, and improving quality of care.
The PPARγ ligand ciglitazone alters expression of multiple cell cycle proteins in androgen-independent human prostate cancer cells
Authors: Lamonica V. Stewart, Besstina Lyles, Tunde Akinyeke, Justin Turner, Patrice Moss
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4658 

Although ligands for the peroxisome proliferator activated receptor gamma (PPARγ) are known to inhibit proliferation of human prostate cancer cells, the mechanisms underlying PPARγ agonist-induced reductions in prostate cancer cell proliferation are not fully understood. In MCF-7 human breast cancer cells, PPARγ ligands inhibit cell proliferation by arresting the cells in the G1 phase of the cell cycle. This G1 arrest is due, in part, to the down-regulation of cyclin D1 and other proteins that regulate the G1-S transition. To determine whether PPARγ agonists alter expression of G1-associated cell cycle proteins in human prostate cancer cells, we tested the effects of the PPARγ ligand ciglitazone on the PC-3 and C4-2 androgen-independent human prostate cancer cell lines. Western blot analysis revealed that ciglitazone concentrations (30-45 μM) that inhibit PC-3 and C4-2 cell proliferation also reduced expression of cyclin D1. Cyclin D1 protein levels were reduced by greater than 50% in both cell lines after twenty-four hours of ciglitazone exposure, and cyclin D1 levels remained depressed after three days of treatment. Transient transfection of cyclin D1-specific siRNA into PC-3 cells not only lowered cyclin D1 protein levels, but also decreased PC-3 cell proliferation, as measured by a reduction in cell number and [3H]-thymidine incorporation. In addition, luciferase-based reporter assays indicated that PPARγ transcriptional activity was increased in PC-3 cells transfected with cyclin D1 siRNA. These data suggest that down-regulation of cyclin D1 by ciglitazone resulted not only in an increase in PPARγ activity but also a decrease in PC-3 cell proliferation. However, cyclin D1 was not the only cell cycle-related protein whose expression was altered by ciglitazone. Ciglitazone reduced protein levels of cyclin D3 within both PC-3 and C4-2 cells. Expression of the cyclin dependent kinase inhibitor p21 was also induced by ciglitazone in the PC-3 cell line. Therefore, while decreases in cyclin D1 appear to play a significant role in ciglitazone-induced inhibition of human prostate cancer cell proliferation, alterations in p21 and cyclin D3 protein expression may also contribute to the net anti-proliferative effect produced by ciglitazone.
A Phase I Study Of The Oral Btk Inhibitor ONO-4059 In Patients With Relapsed/Refractory and High Risk Chronic Lymphocytic Leukaemia (CLL)
Authors: Lionel Karlin, Simon Rule, Nimish Shah, Franck Morschhauser, Louis Terriou, Martin Js Dyer, BMedSci Claire Hutchinson, Chris Fegan, Guillaume Cartron, Tomasz Knurowski, Andrew J Saunders, James G Wright, Hideyuki Honda, Andrew Mazur, Toshio Yoshizawa, Kazuhito Kawabata, Joseph Tp Birkett
Journal: Blood (2013)
Urinary Incontinence in Men
Authors: Natalia Skierkowska, Agnieszka Kujawska, Jakub Husejko, Małgorzata Gajos, Monika Prylińska, Weronika Topka, Marcin Kożuchowski, Oktawia Wysocka, Kornelia Kędziora-Kornatowska, Joanna Androsiuk-Perkowska, Radosław Perkowski, Sławomir Kujawski
Journal: Annals of Internal Medicine (2000)

Summaries for Patients4 April 2000Urinary Incontinence in MenSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-7-200004040-00040 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Urinary incontinence, the involuntary loss of urine, is an important health concern. Incontinence affects many adults, but much more is known about incontinence in women than in men.Why did the researchers do this particular study?The authors wanted to find out how often urinary incontinence happens in men.Who was studied?The researchers studied 840 men (average age about 60 years) who visited primary care clinics at the Louisville Veterans Affairs Medical Center.How was the study done?Male patients in the waiting rooms of the clinics ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Urinary Incontinence among Male Veterans Receiving Care in Primary Care Clinics.”. It is in the 4 April 2000 issue of Annals of Internal Medicine (volume 132, pages 547-551). The authors are.H. Smoger, T.L. Felice, and G.H. Kloecker.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUrinary Incontinence among Male Veterans Receiving Care in Primary Care Clinics Steven H. Smoger , Toni L. Felice , and Goetz H. Kloecker Metrics 4 April 2000Volume 132, Issue 7Page: 547KeywordsBladderHealth care providersHealth information technologyIncontinenceProstate cancerQuality of lifeSurgeryUrinary incontinenceUrinationUrine ePublished: 15 August 2000 Issue Published: 4 April 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
Editorial made extravagant claims
Authors: S. Due
Journal: BMJ (1996)

EDITOR,—The Internet is a truly marvellous way for computers to communicate with each other, and indirectly it allows people to communicate as well. As one who uses the Internet daily as part of my work, I am an enthusiast. I am surprised, however, by the extravagant claims made by Enrico Coiera.1

Coiera states that, as a result of the Internet, the provision of information on health will no longer be the exclusive remit of health care professionals. This …
介入心脏病学知识（五）——急性冠状动脉综合征：不稳定型心绞痛和非ST段抬高性心肌梗死
Authors: Ever, Grech, David, Ramsdale, 李崇剑（译）, 吴永健（校）
Journal: BMJ (2005)

急性冠状动脉综合征是指一组急性心肌缺血症状，包括不稳定型心绞痛、非ST段抬高性心肌梗死（通常没有ST段抬高）和ST段抬高性心肌梗死（多见持续性ST段抬高）。本文将重点讨论经皮冠状动脉介入治疗在不稳定型心绞痛和非ST段抬高性心肌梗死治疗中的作用。
Drug-Induced Extrapyramidal Symptoms
Authors: W P Jackson
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 836: Downregulation of microRNA-1/microRNA-133 and Overexpression of Sp1 activates Re-expression of Pacemaker Channel Genes HCN2 and HCN4 in Hypertrophic Heart
Authors: Xiaobin Luo, Huixian Lin, Zhiming Du, Jiening Xiao, Yanjie Lu, Baofeng Yang, Zhiguo Wang
Journal: Circulation (2007)

The pacemaker current If, carried by hyperpolarization-activated channels encoded mainly by HCN2 and HCN4 genes in the heart, plays an important role in rhythmogenesis. Their expressions reportedly increase in hypertrophic and failing hearts, contributing to arrhythmogenesis under these pathological conditions. However, how their expressions are controlled remained unclear. We performed a mechanistic study on transcriptional and posttranscriptional regulation of HCN2 and HCN4 by transcription factors and microRNAs. We identified the transcription start sites and core promoter regions of these genes, and revealed striking similarities between HCN2 and HCN4 promoter regions and ubiquitous Sp1 protein as a common transactivator of HCN2/HCN4. We experimentally established HCN2 mRNA as a target for repression by the muscle-specific miRNAs miR-1 and miR-133, and HCN4 as a target for miR-1 only. We further unraveled robust increases in HCN2/HCN4 transcripts and protein levels in a rat model of left ventricular h...
Age at diagnosis in children with primary ciliary dyskinesia (PCD) in Russian Federation (RF)
Authors: Liliya Selimzyanova, Elena Sereda
Journal: European Respiratory Journal (2011)

Background:  PCD is often diagnosed late.   Aim:  To identify age at PCD diagnosis in children in RF.   Methods:  A retrospective study of medical histories in 43 patients with PCD.   Results:  We followed up19 girls (44%), 24 boys (56%). Situs inversus was revealed in 30 (70%), situs solitus – in 13 (30%) patients. Median age at onset of the first symptoms was 0 (IQR 0-0, range 0 to 4). 20 patients were diagnosed at age 0-4 years, 11 at age 5-9, 10 at age 10-14, 2 at age 15-18. Median age at diagnosis in all patients was 5 yrs (IQR 1-10,2, range 0-16). Median age at diagnosis was lower in children with situs inversus compared to those without (3,5 (IQR 0,7-7, range 0-14) vs 9 yrs (IQR 6-13, range 0,6-16), p   Conclusion:  PCD in Russian Federation is diagnosed at an average of 5 years. Diagnosis of PCD without situs inversus presents particular difficulties. Children with PCD usually are directed to pulmonologists late.
Abstract 17271: An Alternatively Spliced Kcnh2 Variant Restores Cardiac Repolarization in a Model of Long QT Syndrome: Implications for Phenotypic Variation in Human Long QT Syndrome
Authors: Chuanchau J Jou, Jiantao Bian, Angelica Lopez, Zhi Su, Martin Tristani-Firouzi
Journal: Circulation (2011)

Introduction: Mutations in KCNH2 ( HERG1 , LQT-2) are a common cause of Long QT Syndrome (LQTS). Despite sharing the same mutation, affected family members often display marked differences in disease severity, including risk of sudden cardiac death. The genetic basis of this phenotypic variation is not known. We previously validated a zebrafish model of human LQT-2. Here, we use a repolarization-deficient zebrafish mutant ( breakdance , bre ) to probe the molecular basis of phenotypic variation. Methods: Bre is due to a recessive kchn2 mutation (I59S) within the cytoplasmic N-terminal domain. 5’-RACE and qPCR were used to clone and quantify novel N-terminal variants from zebrafish and human heart. Biophysical properties of zebrafish and human variants were characterized using voltage- and patch-clamp techniques. In vivo functional effects were determined by over-expressing the variants in knch2-null zebrafish embryos, and assaying for ability to restore ventricular repolarization by characterizing phenotypes of the embryonic heart at 48 hour-post-fertilization. Results: We identified a novel, alternatively spliced N-terminal variant, kcnh2 1c , with in-frame deletion of Exon 2-6. The 1c variant constitutes ~40% of the kcnh2 transcript, and is expressed 4X greater in atrium than ventricle. The 1c variant deletes the disease-causing mutation, I59S. Activation of kcnh2 1c channels is similar to WT, but deactivation is accelerated. In vivo , kcnh2 1c functions similar to WT, and is able to partially restore ventricular repolarization in knch2-null zebrafish. We identified 2 novel N-terminal variants in human heart that are also differentially expressed between the atrium and ventricle. Biophysical function of the human variants is similar to zebrafish 1c. Conclusion: Kcnh2 1c modulates cardiac repolarization in the bre mutant by excising the disease-causing mutation. Approximately 30% of LQT-2 mutations localize to the N-terminus, and are subject to alternative splicing. By excising N-terminal mutations human 1c variants may modulate repolarization and influence phenotypic expression in LQTS.
Evaluation of association between OSA and metabolic syndrome, insulin resistance and Hs-CRP
Authors: Abolhasan Halvani, Maryam Salami, Mahmood Karimi
Journal: European Respiratory Journal (2011)

Background:  Obstructive sleep apnoea (OSA) is an important medical problem that shares many cardiovascular risk factors with metabolic syndrome. This study aimed to evaluate the possible association of OSA severity with metabolic syndrome, Insulin resistance and Hs-CRP.   Methods:  We evaluated 90 subjects who suspected for OSA (54.92 years). Blood sampling was taken after 12 hours fasting for glucose, insulin, high-density lipoprotein (HDL)-cholesterol, triglycerides, high-sensitivity C-reactive protein (Hs-CRP), and then Overnight polysomnograghy was done. Insulin resistance was assessed by the homeostatic model (HOMA) and metabolic syndrome was evaluated according to The National Cholesterol Education Program9s Adult Treatment Panel III report (ATP III), and subjects categorized by OSA severity. We compared three groups: without OSA, mild OSA and moderate to severe OSA.   Results:  28 subjects hadn9t OSA, 28 and 34 subjects had mild and moderate to severe OSA, respectively. Metabolic score was 3.29±1.21, 3.07±1.27 and 3.59±1.048 in subjects without OSA and mild OSA and moderate to severe OSA, respectively (r=0.13 p=0.22).HOMA index was 56.87±55.84, 106.42±199.68 and 96.23±127.81 (r=0.33 p=0.37) and hs-CRP levels was 1.62±1.8, 2.10±2.24 and 2.36±2.38 ng/ml (r=0.21 p=0.38) order in above three subjects. There was significant association between metabolic score and HOMA index (p=0.01) and also between metabolic score and hs-CRP level (p=0.02)   Conclusion:  Although Hs-CRP, insulin resistance and metabolic syndrome increase with OSA severity but there was not significant association between apnea hypopnea index and Hs-CRP, insulin resistance and metabolic syndrome.
Soundings: PIGPEN therapy for head lice
Authors: Trisha Greenhalgh
Journal: BMJ (2003)

Background A review of the evidence suggests that chemical treatment is superior to combing in the treatment of head lice (BMJ 2003;326: 1256-8 [PubMed]). But there's combing and combing.

Participants and methods Two hundred urchins were recruited from a school playground and randomised using a culturally congruent method (“Oi, you lot—number off”). Exclusion criteria included congenital alopecia (n=1), dreadlocks (n=4), and having a parent who showed enthusiasm for rubbing organophosphates into his or her child's head (n=0). The intervention group were each supplied with a plain white envelope (0.03p, Woolworths), a plastic nit comb (40p, Boots), and a magnifying glass (free with cornflakes).

In phase 1, the child was offered 1p for every live louse caught in the envelope. The creatures were carefully counted and a strict taxonomy applied (“that's only a bit of skin,” “he's not wriggling,” etc), and the debt paid in cash. In phase 2, the stakes were raised to 10p, and in phase 3 to 50p.

Results The mean fee paid to each child was: in phase 1, 31p (95% confidence interval 16 to 78); in phase 2, 63p (7 to 99); and in phase 3, 21p (0 to 157). No parent in the intervention group reported physical abuse from his or her child as a result of attempting to apply chemicals without full consent, and no child was rushed to casualty with organophosphates in the eyes. All were nit free a week later. By three months all had been reinfested—that's nits for you.

Conclusion Parent-incentivised, graded, patient extraction of nits (PIGPEN) therapy is an acceptable, safe, and cost effective treatment.

Discussion Previous studies of physical treatments for head lice have ignored the social and psychological dimensions. “Wet combing” using liberal application of hair conditioner requires passive co-operation from the child and runs counter to prevailing norms (see, for example, negative role models in popular culture—eg, Softie Walter,1 Draco Malfoy,2 Olive Oyl3). In contrast, PIGPEN therapy draws subliminally on contemporary peer written literature to develop a ghoulish interest in micro-organisms and apply creative schemes to extract money from parents.4
Abstract 1166: In-vivo Serial Assessment of Aortic Aneurysm Formation in a Hyperlipidimic Mouse Model
Authors: Gregory Turner, Alan Olzinski, Roberta Bernard, Karpagam Aravindhan, Heather Karr, Robert Willette, Peter Gough, Beat Jucker
Journal: Circulation (2007)

Introduction Abdominal aortic aneurysms (AAA) can be consistently produced in hyperlipidimic mice by continuous infusion of Angiotensin-II (Ang-II). MRI allows for AAA visualization in-vivo with sufficient spatial resolution to assess changes in aneurysm size and morphology. Bright-blood contrast allows for detection of medial breaks, an index of AAA severity, and USPIO contrast agent uptake allows for detection of macrophage activity in AAA. For this study we used MRI to characterize AAA development in a murine model and examined the effect of the broad-based MMP inhibitor, doxycycline, on AAA progression over a 4 week period. Methods Osmotic pumps were implanted subcutaneously in ApoE−/− mice for infusion of Ang-II (1000 ng/kg/min) over 4 weeks. Animals were given 30 mg/kg/day doxycycline or vehicle (n=15 per group) via drinking water. Weekly scans were performed using a 9.4T MRI scanner. In addition, uptake of USPIO (Combidex, 1000 μmol/kg) in AAA was measured. Results MRI revealed two distinct features of AAA development: remodeling of the adventitia which compresses the aortic lumen (Fig 1B ) and a break in the medial wall characterized by bright-blood signal within the AAA (Fig 1C ). Higher incidence of AAA formation in the vehicle vs. doxycycline group was detected along with a significantly larger (P&lt;.01) AAA area. For mice given USPIO, MRI revealed signal loss in the periphery and shoulder region of the AAA which corresponded to macrophage rich regions as determined by IHC. Conclusion These results demonstrate MRI’s potential for non-invasively and temporally assessing AAA development and pharmacological intervention in this pre-clinical cardiovascular disease model.
Abstract 8724: Short and Long-Term Mortality of Pediatric Stroke: A Fourteen Year Statewide Study
Authors: Sampada K Gandhi, James S McKinney, Jeanine E Sedjro, Jerry Q Cheng, Yingzi Deng, Nora M Cosgrove, Javier Cabrera, John B Kostis
Journal: Circulation (2011)

Objectives: Since there are no recent data on the short and long-term mortality of pediatric stroke, we examined the 30-day, 1 year and 5 year mortality of children admitted to New Jersey (NJ) hospitals with a diagnosis of stroke using a statewide administrative database. Methods: We used the Myocardial Infarction Data Acquisition System (MIDAS) database, which includes demographic and clinical data on children (aged &gt; 30 days to ≤ 19 years) admitted with a first time diagnosis of stroke to all non-federal hospitals in NJ between 1994 and 2007. Deaths were ascertained by matching the MIDAS records to death information from NJ Death Registration Files within 30 days, 1 year and 5 years from the index admission. Cox proportional hazards regression models were fitted to assess the effect of demographic characteristics and predisposing conditions of stroke on time to death. Results: Thirty-day, 1-year and 5-year mortality rates were 10.2%, 13.7% and 16.2% respectively (Figure 1a) among 1,034 children admitted during the study period. At all time periods, mortality rates from hemorrhagic stroke were 2-3 times higher compared to ischemic stroke and adjusted survival from hemorrhagic stroke was significantly lower compared to ischemic stroke (p&lt; 0.0001) (Figure 1b, 1c, 1d). Twenty-four percent of the deaths were due to a cardiovascular cause, mostly comprising of cerebrovascular hemorrhage and congenital malformations of the circulatory system. The remaining 76% percent of the deaths were due to a non-cardiovascular cause such as cancer, diseases or malformations of nervous system. After adjusting for all covariates, important predictors of mortality were: type of stroke, prior history of cardiac dysrhythmia, CNS tumor, leukemia, human immunodeficiency virus (HIV) and meningitis. Conclusion: At 5 years, roughly 85% of the children with stroke were alive. However, children with hemorrhagic stroke were at a much higher risk of death compared to those with ischemic stroke.
False-positive I-131 accumulation in a liver cyst in a patient with thyroid carcinoma.
Authors: CHIO OKUYAMA, YO USHIJIMA, MASAYUKI KIKKAWA, TAKUJI YAMAGAMI, TOSHIYUKI NAKAMURA, KANA KOBAYASHI, TATSUYA HIROTA, TSUNEHIKO NISHIMURA
Journal: Clinical Nuclear Medicine (2001)

Iodine-131 uptake was seen in the right upper abdominal quadrant of a patient with postoperative differentiated thyroid cancer that corresponded with a large liver cyst.
补充抗氧化剂对预防马拉维儿童恶性营养不良的作用：随机、双盲、安慰剂对照试验
Authors: Heather, Ciliberto, Michael, Andreé, Briend, Per, Ashorn, Dennis, Bier, Mark, Manary, 胡恩坦（译）
Journal: BMJ (2005)