tbuckley/cabot-search huggingface dataset:
Virtual Group Exercise Program Improved Long COVID Symptoms
Authors: Emily Harris
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identifying Core Outcome Domains in Chronic Skin Disease Using the Best-Worst Scaling Method
Authors: Ali Shields, Frances K. Barg, Wendy Smith Begolka, Kathy Sage, Kelly Druby, George C. Gondo, David J. Margolis, Andrea L. Pusic, John S. Barbieri
Journal: JAMA Dermatology (2024)

The use of patient-reported outcome measures (PROMs) potentially holds promise as an opportunity to improve outcomes and quality of care for patients with skin disease, but the routine use of PROMs remains limited. While the Patient-Reported Outcomes Measurement Information System (PROMIS) has several strengths and domains relevant to those with chronic skin disease, it is not clear which are most useful.
High Lipoprotein(a) May Increase CVD Risk Even Without Inflammation
Authors: Emily Harris
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Racial and Ethnic Disparities in Patient Restraint in Emergency Departments by Police Transport Status
Authors: Erika Chang-Sing, Colin M. Smith, Jane P. Gagliardi, Laura D. Cramer, Leah Robinson, Dhruvil Shah, Morgan Brinker, Patelle Jivalagian, Yue Hu, Nicholas A. Turner, Ambrose H. Wong
Journal: JAMA Network Open (2024)

Importance Black patients are more likely than White patients to be restrained during behavioral crises in emergency departments (EDs). Although the perils of policing mental health for Black individuals are recognized, it is unclear whether or to what extent police transport mediates the association between Black race and use of physical restraint in EDs. Objective To evaluate the degree to which police transport mediates the association between Black race and use of physical restraint in EDs. Design, Setting, and Participants This retrospective, cross-sectional study used electronic health record data from ED visits by adults (aged ≥18 years) to 3 hospitals in the southeastern US and 10 in the northeastern US between January 1, 2015, and December 31, 2022. Data were analyzed from September 1, 2022, to May 30, 2023. Exposures Race, ethnicity, and police transport to the hospital. Main Outcomes and Measures The primary outcome variable was the presence of an order for restraints during an ED visit. Results A total of 4 263 437 ED visits by 1 257 339 patients (55.5% of visits by female and 44.5% by male patients; 26.1% by patients 65 years or older) were included in the study. Black patients accounted for 27.5% of visits; Hispanic patients, 17.6%; White patients, 50.3%; and other or unknown race or ethnicity, 4.6%. In models adjusted for age, sex, site, previous behavioral or psychiatric history, and visit diagnoses, Black patients were at increased odds of experiencing restraint compared with White patients (adjusted odds ratio [AOR], 1.33 [95% CI, 1.28-1.37]). Within the mediation analysis, Black patients had higher odds of being brought to the hospital by police compared with all other patients (AOR, 1.38 [95% CI, 1.34-1.42]). Patients brought to the ED under police transport had increased odds of experiencing restraint compared with all other modes of transport (AOR, 5.51 [95% CI, 5.21-5.82]). The estimated proportion of use of restraints for Black patients mediated by police transport was 10.70% (95% CI, 9.26%-12.53%). Conclusions and Relevance In this cross-sectional study of ED visits across 13 hospitals, police transport may have mediated the association between Black race and use of physical restraint. These findings suggest a need to further explore the mechanisms by which transport to emergency care may influence disparate restrictive interventions for patients experiencing behavioral emergencies.
Error in Supplement 2
Journal: JAMA Network Open (2024)

José Ignacio Ruiz Azpiazu, MD; Patricia Fernández del Valle, MStat; Alfredo Echarri Sucunza, PhD; Jose Antonio Iglesias Vázquez, PhD; Carmen del Pozo, MD; Emily Caitlin Lily Knox, MStat; Youcef Azeli, PhD; Francisco José Sánchez García, PhD; Cristian Fernández Barreras, MD; María Carmen Escriche, MD; Pedro Jesús Martín Hernández, MD; Marcos Juanes García, MD; Natividad Ramos García, MD; Sonia Royo Embid, MD; José Antonio Cortés Ramas, MD; Inmaculada Mateo-Rodríguez, PhD; Silvia Sola Muñoz, PhD; Elena Alcalá-Zamora Marcó, RN; Ana Belén Fornér Canos, MD; Belén Mainar Gómez, MD; Pedro Dacal Pérez, MD; Carmen Camacho Leis, MD; Jose Javier García Cortés, MD; José Manuel Hernández Royano, MD; Xavier Escalada Roig, PhD; Antonio Daponte Codina, ScD; Fernando Rosell Ortiz, PhD; OHSCAR Investigators Group; Luis Olavarria Govantes; María J Luque-Hernández; Miguel A Paz-Rodríguez; Fernando Ayuso-Batista; Carmen Gutiérrez-García ; María R Soto-García ; María A Caballero-García; Roberto Antón Ramas; Marcel Chueca García ; Ignacio González Herráiz; Maria I Ceniceros-Rozalen; Esther Arias Moya; María N Gonzalez Quintana; Faustino Redondo Revilla; Cesar M Guerra García ; Juan Valenciano Rodriguez; Juan J Lara Sánchez; Cristina Martinez-Villalobos Aguilar; Almudena Noriega Miguez; Leticia Sánchez del Rio; Vanessa Tomàs Fort; Carlos Sanchis Nuñez; Jose L Nieto Ferrando; Itziar I Ilzarbe Ucelay; Francesc X Jimenez Fabrega; Ruth Salaberria Udabe; Fernando Vicente Casanova; Susana Batres Gomez; Francisco J Medina Aragon; Xesús M López Alvarez; Marta Dorribo Masid; María J García-Ochoa Blanco; Jose M Jose María Navalpotro Pascual; Alicia Villar Arias; Manuel J González León; Belén Muñoz Isabel; Jose A Hortelano Alonso; Francisco A Jose Peinado; Francisco A Guirao Salinas; Cruz Lopez Perez; Junior J García Mendoza; Miguel Artigas; Félix Rivera Sánz; Alvaro Fernández González
Erratum. Computed Tomography Versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease. Diabetes Care 2023;46:2015–2023
Authors: Theodora Benedek, Viktoria Wieske, Bálint Szilveszter, Klaus F. Kofoed, Patrick Donnelly, José Rodriguez-Palomares, Andrejs Erglis, Josef Veselka, Gintarė Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca Saba, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Bela Merkely, Per E. Sigvardsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Martin Horváth, Antanas Jankauskas, Filip Ađić, Michael Woinke, Niall Mulvihill, Iñigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Milica Stefanovic, Massimo Mancone, Donata Kuśmierz, Gudrun Feuchtner, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Marco Melis, Michael Fisher, Melinda Boussoussou, Charlotte Kragelund, Rosca Aurelian, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Mihály Károlyi, Jens D. Hove, Ioana Rodean, Susan Regan, Hug Cuéllar Calabria, László Gellér, Linnea Larsen, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Mahmoud Mohamed, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, John Danesh, Melanie Estrella, Maria Bosserdt, Peter Martus, Jonathan D. Dodd, Marc Dewey
Journal: Diabetes Care (2024)

In the abstract of the article cited above, the clinical trial number for DISCHARGE (NCT02400229) was inadvertently omitted. The abstract has been revised to include the ClinicalTrials.gov identification. The editors apologize for the error. The online version of the article (https://doi.org/10.2337/dc23-0710) has been updated to correct the error.
Accelerometer-Measured Physical Activity, Sedentary Time, and Heart Failure Risk in Women Aged 63 to 99 Years
Authors: Michael J. LaMonte, Andrea Z. LaCroix, Steve Nguyen, Kelly R. Evenson, Chongzhi Di, Marcia L. Stefanick, Eric T. Hyde, Blake Anuskiewicz, Charles B. Eaton
Journal: JAMA Cardiology (2024)

Heart failure (HF) prevention is paramount to public health in the 21st century. To examine incident HF and its subtypes with preserved ejection fraction (HFpEF) and reduced EF (HFrEF) according to accelerometer-measured physical activity (PA) and sedentary time. This was a prospective cohort study, the Objective Physical Activity and Cardiovascular Health (OPACH) in Older Women study, conducted from March 2012 to April 2014. Included in the analysis were women aged 63 to 99 years without known HF, who completed hip-worn triaxial accelerometry for 7 consecutive days. Follow-up for incident HF occurred through February 2022. Data were analyzed from March to December 2023. Daily PA (total, light, moderate to vigorous PA [MVPA], steps) and sedentary (total, mean bout duration) behavior. Adjudicated incident HF, HFpEF, and HFrEF. A total of 5951 women (mean [SD] age, 78.6 [6.8] years) without known HF were included in this analysis. Women self-identified with the following race and ethnicity categories: 2004 non-Hispanic Black (33.7%), 1022 Hispanic (17.2%), and 2925 non-Hispanic White (49.2%). There were 407 HF cases (257 HFpEF; 110 HFrEF) identified through a mean (SD) of 7.5 (2.6) years (range, 0.01-9.9 years) of follow-up. Fully adjusted hazard ratios (HRs) for overall HF, HFpEF, and HFrEF associated with a 1-SD increment were 0.85 (95% CI, 0.75-0.95), 0.78 (95% CI, 0.67-0.91), and 1.02 (95% CI, 0.81-1.28) for minutes per day total PA; 0.74 (95% CI, 0.63-0.88), 0.71 (95% CI, 0.57-0.88), and 0.83 (95% CI, 0.62-1.12) for steps per day; and 1.17 (95% CI, 1.04-1.33), 1.29 (95% CI, 1.10-1.51), and 0.94 (95% CI, 0.75-1.18) for minutes per day total sedentary. Cubic spline curves for overall HF and HFpEF were significant inverse for total PA and steps per day and positive for total sedentary. Light PA and MVPA were inversely associated with overall HF (HR per 1 SD: 0.88; 95% CI, 0.78-0.98 and 0.84; 95% CI, 0.73-0.97) and HFpEF (0.80; 95% CI, 0.70-0.93 and 0.85; 95% CI, 0.72-1.01) but not HFrEF. Associations did not meaningfully differ when stratified by age, race and ethnicity, body mass index, physical function, or comorbidity score. Results for sedentary bout duration were inconsistent. Higher accelerometer-measured PA (MVPA, light PA, steps per day) was associated with lower risk (and greater total sedentary time with higher risk) of overall HF and HFpEF in a racially and ethnically diverse cohort of older women. Increasing PA and reducing sedentary time for primary HFpEF prevention may have relevant implications for cardiovascular resilience and healthy aging in later life.
The revised International Code of Medical Ethics unites doctors under one global medical ethos
Authors: Ramin W Parsa-Parsi, Raanan Gillon, Urban Wiesing
Journal: BMJ (2024)

The World Medical Association's revised International Code of Medical Ethics offers a core set of ethical norms for all doctors worldwide to follow, write <b>Ramin W Parsa-Parsi</b>, <b>Raanan Gillon</b>, and <b>Urban Wiesing</b>
Fenton‐like Reaction Inspired “·OH Catalyzed” Osteogenic Process for the Treatment of Osteoporosis
Authors: Jingcheng Wang, Jing Ye, Guoyu Yang, Jialiang Xie, Xinxin Miao, Jianjian Deng, Tianlong Wu, Xigao Cheng, Xiaolei Wang
Journal: Advanced Healthcare Materials (2024)

Inspired by the Fenton-like reaction, this work combines copper peroxide (CP) nanoparticles with black phosphorus (BP) nanosheets to form a hydroxyl radical (·OH)-centered "catalytic" osteogenic system. CP-produced ·OH interacts with BP to rapidly produce a large amount of phosphate ions, thus accelerating self-mineralization and promoting bone formation. In turn, BP not only exerts anti-inflammatory effects, thereby providing a favorable microenvironment for bone formation, but also offsets the potential toxicity of CP induced by reactive oxygen species (ROS). Together with copper ions (Cu
Continuous Glucose Monitoring–Based Metrics and Hypoglycemia Duration in Insulin-Experienced Individuals With Long-standing Type 2 Diabetes Switched From a Daily Basal Insulin to Once-Weekly Insulin Icodec: Post Hoc Analysis of ONWARDS 2 and ONWARDS 4
Authors: Harpreet S. Bajaj, Björg Ásbjörnsdóttir, Lisbeth Carstensen, Christian Laugesen, Chantal Mathieu, Athena Philis-Tsimikas, Tadej Battelino
Journal: Diabetes Care (2024)

This post hoc analysis assessed continuous glucose monitoring (CGM)-based metrics and hypoglycemia duration with once-weekly insulin icodec versus once-daily basal insulin analogs in insulin-experienced individuals with long-standing type 2 diabetes from two 26-week phase 3a trials (ONWARDS 2 and ONWARDS 4).
Relative prognostic value of flow cytometric measurable residual disease before allogeneic hematopoietic cell transplantation for adults with <scp>MDS</scp>/<scp>AML</scp> or <scp>AML</scp>
Authors: Corentin Orvain, Naveed Ali, Megan Othus, Eduardo Rodríguez‐Arbolí, Filippo Milano, Calvin M. Le, Brenda M. Sandmaier, Bart L. Scott, Frederick R. Appelbaum, Roland B. Walter
Journal: American Journal of Hematology (2024)

Multiparameter flow cytometry (MFC) measurable residual disease (MRD) before allogeneic hematopoietic cell transplantation (HCT) independently predicts poor outcomes in acute myeloid leukemia (AML). Conversely, its prognostic value in the newly defined disease entity, myelodysplastic neoplasm (MDS)/AML is unknown. To assess the relationship between disease type, pre-HCT MRD, and post-HCT outcomes, we retrospectively analyzed 1265 adults with MDS/AML (n = 151) or AML (n = 1114) who received a first allograft in first or second morphologic remission at a single institution between April 2006 and March 2023. At 3 years, relapse rates (29% for MDS/AML vs. 29% for AML, p = .98), relapse-free survival (RFS; 50% vs. 55%, p = .22), overall survival (OS; 52% vs. 60%, p = .073), and non-relapse mortality (22% vs. 16%, p = .14) were not statistically significantly different. However, a significant interaction was found between pre-HCT MFC MRD and disease type (MDS/AML vs. AML) for relapse (p = .009), RFS (p = .011), and OS (p = .039). The interaction models indicated that the hazard ratios (HRs) for the association between pre-HCT MRD and post-HCT outcomes were lower in patients with MDS/AML (for relapse: HR = 1.75 [0.97-3.15] in MDS/AML vs. 4.13 [3.31-5.16] in AML; for RFS: HR = 1.58 [1.02-2.45] vs. 2.98 [2.48-3.58]; for OS: HR = 1.50 [0.96-2.35] vs. 2.52 [2.09-3.06]). On the other hand, residual cytogenetic abnormalities at the time of HCT were equally informative in MDS/AML as in AML patients. Our data indicate that MFC-based pre-HCT MRD testing, but not testing for residual cytogenetic abnormalities, is less informative for MDS/AML than AML patients when used for prognostication of post-HCT outcomes.
CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors
Authors: Xin Lei, Daniël C. de Groot, Marij J. P. Welters, Tom de Wit, Ellen Schrama, Hans van Eenennaam, Saskia J. Santegoets, Timo Oosenbrug, Annemarthe van der Veen, Joris L. Vos, Charlotte L. Zuur, Noel F. C. C. de Miranda, Heinz Jacobs, Sjoerd H. van der Burg, Jannie Borst, Yanling Xiao
Journal: Cellular and Molecular Immunology (2024)

CD4
Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis
Authors: Xin Huang, Weiyue Zhang
Journal: Ageing Research Reviews (2024)

Arthritis has become the most common joint disease globally. Current attention has shifted towards preventing the disease and exploring pharmaceutical and surgical treatments for early-stage arthritis. M2 macrophages are known for their anti-inflammatory properties and their ability to support cartilage repair, offering relief from arthritis. Whereas, it remains a great challenge to promote the beneficial secretion of M2 macrophages to prevent the progression of arthritis. Therefore, it is warranted to investigate new strategies that could use the functions of M2 macrophages and enhance its therapeutic effects. This review aims to explore the macrophage cell membrane-coated biomimetic nanovesicles for targeted treatment of arthritis such as osteoarthritis (OA), rheumatoid arthritis (RA), and gouty arthritis (GA). Cell membrane-camouflaged biomimetic nanovesicle has attracted increasing attention, which successfully combine the advantages and properties of both cell membrane and delivered drug. We discuss the roles of macrophages in the pathophysiology and therapeutic targets of arthritis. Then, the common preparation strategies of macrophage membrane-coated nanovesicles are concluded. Moreover, we investigate the applications of macrophage cell membrane-camouflaged nanovesicles for arthritis, such as OA, RA, and GA. Taken together, macrophage cell membrane-camouflaged nanovesicles hold the tremendous prospect for biomedical applications in the targeted treatment of arthritis.
Personality traits and pre-treatment beliefs and cognitions predicting patient adherence to continuous positive airway pressure: A systematic review
Authors: P Kasetti, N F Husain, T C Skinner, K Asimakopoulou, J Steier, S A Sathyapala
Journal: Sleep Medicine Reviews (2024)

Adherence to Continuous Positive Airway Pressure (CPAP) for obstructive sleep apnoea (OSA) can be improved by behavioural interventions which modify patients' beliefs and cognitions about OSA, CPAP, and themselves. We have conducted the first systematic review of the literature on beliefs and cognitions held before starting treatment, and personality (which influences the former) that predict the decision to purchase or start CPAP, or CPAP adherence one month or more after CPAP initiation. A systematic search and screen of articles identified 21 eligible publications from an initial 1317. Quality assessment performed using an adapted Newcastle-Ottawa Scale demonstrated that 13 (62%) studies were poor quality and only seven (33%) were high quality. Eighteen factors, such as self-efficacy (confidence) in using CPAP and value placed on health predicted CPAP adherence; however, for only six (33%), utility as an intervention target is known, from calculation of individual predictive power. Studies did not use new behavioural frameworks effective at explaining adherence behaviours, nor did they interview patients to collect in-depth data on barriers and facilitators of CPAP use. Future studies cannot have these limitations if high quality evidence is to be generated for intervention development, which is currently sparse as highlighted by this review.
Emotion regulation and emotion dysregulation in children and adolescents with Autism Spectrum Disorder: A meta-analysis of evaluation and intervention studies
Authors: Damián Restoy, Montserrat Oriol-Escudé, Teresa Alonzo-Castillo, María Magán-Maganto, Ricardo Canal-Bedia, Emiliano Díez-Villoria, Laura Gisbert-Gustemps, Imanol Setién-Ramos, María Martínez-Ramírez, Josep Antoni Ramos-Quiroga, Jorge Lugo-Marín
Journal: Clinical Psychology Review (2024)

Children and adolescents with Autism Spectrum Disorder (ASD) often experience challenges in emotion regulation (ER) and emotion dysregulation (ED) which can interfere with their adaptive functioning. This study aimed to systematically review and meta-analyze the evidence on ER/ED in children and/or adolescents with ASD, examining its relationship with the following variables: internalizing and externalizing symptoms, cognitive function and social skills, and the effectiveness of non-pharmacological interventions addressing ER difficulties. Both electronic and manual searches were conducted to identify potential studies. Fifty-five studies were included in the meta-analysis. A statistically significant between-group difference was found, suggesting greater ER/ED challenges in the ASD group. Also, the ASD group showed more maladaptive ER strategies and fewer adaptive ER strategies compared to the non-ASD participants. Additionally, more severe ASD and poorer social skills were associated with greater ED and poorer ER skills, respectivelly. Furthermore, there was a significant correlation between internalizing symptomatology and both adaptive and maladaptive ER strategies. Studies of non-pharmacological interventions showed significant improvement in both ER and ED. These results imply that assessing ER/ED in children and adolescents with ASD should be part of the evaluation process, and it should also be a focal point for intervention in this population.
Prognostic Impact and Spatial Interplay of Immune Cells in Urothelial Cancer
Authors: Nicolaus F. Debatin, Elena Bady, Tim Mandelkow, Zhihao Huang, Magalie C.J. Lurati, Jonas B. Raedler, Jan H. Müller, Eik Vettorazzi, Henning Plage, Henrik Samtleben, Tobias Klatte, Sebastian Hofbauer, Sefer Elezkurtaj, Kira Furlano, Sarah Weinberger, Paul Giacomo Bruch, David Horst, Florian Roßner, Simon Schallenberg, Andreas H. Marx, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten H. Ecke, Steffen Hallmann, Stefan Koch, Nico Adamini, Maximilian Lennartz, Sarah Minner, Ronald Simon, Guido Sauter, Henrik Zecha, Thorsten Schlomm, Niclas C. Blessin
Journal: European Urology (2024)

Quantity and the spatial relationship of specific immune cell types can provide prognostic information in bladder cancer. The objective of the study was to characterize the spatial interplay and prognostic role of different immune cell subpopulations in bladder cancer.