AB1046 EVALUATION OF ACCRUAL DAMAGE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: COMPARISON OF DATA FROM THE NATIONAL CROSS-SECTIONAL AND PROSPECTIVE LUPUS REGISTRY
Authors: J. M. Dapeña, L. Garcia, C. Gobbi, R. Quintana, P. Alba, S. Roverano, A. Alvarez, C. Graff, C. Pisoni, A. Spindler, C. Gomez, H. M. Figueredo, S. Papasidero, R. H. Paniego, M. C. De la Vega, E. E. Civit, L. González Lucero, M. V. Martire, R. Águila Maldonado, S. A. Gordon Dolimpio, M. L. Micelli, R. Nieto, G. Rausch, V. Góngora, M. A. D´amico, D. Dubinsky, A. O. Orden, J. Zacariaz, J. Romero, M. Pera, M. A. Goñi, O. Rillo, R. Baez, V. Arturi, A. Gonzalez, F. Vivero, M. E. Bedoya, M. Schmid, V. Caputo, M. S. Larroude, N. Dominguez, G. Gomez, G. Rodriguez, J. Marin, M. V. Collado, M. Jorfen, Z. Bedran, A. Curti, M. V. Gazzoni, J. Sarano, P. Finucci, R. Rojas Tessel, M. Arias Saavedra, M. E. Sattler, M. Machado Escobar, P. Astesana, U. V. Paris, J. M. Vandale, M. J. Santa Cruz, B. Pons-Estel, P. M. Corbalán, L. M. Mendoza Martinez, G. Alle, B. Sardi, M. Sarde, M. F. Gordillo, G. Pons-Estel, M. A. García
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Adequate control of disease activity and early therapeutic interventions can minimize damage in Systemic Lupus Erythematosus (SLE) [1-2] <h3>Objectives:</h3> The aim of this study was to describe and compare damage in patients with SLE from the national cross-sectional and prospective registries of the Argentine Society of Rheumatology (RELESSAR) and to assess associated factors. <h3>Methods:</h3> A cross- sectional study was performing using two national lupus registries: the cross-sectional (RELESSAR-CS) and the prospective (RELESSAR-P) ones. Data from 1648 patients across 67 centers were analyzed, with 9-year Abstract Preview difference between both initiatives. Sociodemographic data, clinical manifestations, hospitalizations, activity and damage scores in patients with less than 5 years of SLE evolution were analysed. Statistical analysis: Descriptive statistics, Chi2, Fisher, Student's t, or Wilcoxon tests as appropriate. Univariate/multivariate logistic regression identified factors associated with accrual damage. <h3>Results:</h3> Data were collected from RELESSAR-CS (n=1515) and the basal visit of RELESSAR-P (n=133). Cumulative damage was evaluated by domain (Table 1). Patients with &lt;5 years of evolution from both registries were compared (Table 2): patients who belonged to RELESSAR-CS were younger (p=O.002), had longer diagnosis delay (p&lt;O.001), and lower use of rituximab (p&lt;O.001). No difference in accrual damage was found. Patients with (n=311) and without cumulative damage (n=428) from both registries were compared. Patients with SLICC/SDI 21 were Older (36126-471 vs 31[25-411, p&lt;O.001) and showed more frequency of male sex (14% vs 9%, p=O.046) and mestizos (58% vs 44%, p&lt;0.001), and lower educational level (12110-15] vs 12111-15], p=O.019). Additionally, they exhibited higher SLEDAI activity (2[0-6] vs 1 (0-4], p=O.008) and increased use of MTX (26% vs 18%, p=O.021), CYC (38% vs 21%, p&lt;O.001), and MMF (27% vs 19%, p=O.021). They had a higher rate of hospitalizations (64% vs 44%, p&lt;O.001) and infections (18% vs 9%, p&lt;O.001). Age, mestizo ethnicity, SLEDAI, and the use Of MTX and CYC were independently associated with damage. <h3>Conclusion:</h3> Musculoskeletal domain was affected less frequently in the prospective registry, which could be associated with lower frequency of avascular necrosis and lower use of corticosteroids. Age, mestizo ethnicity, SLEDAI, and the use of MTX and CYC were significantly associated with damage. <h3>REFERENCES:</h3> [1] Rua-Figueroa Fernández de Larrinoa Í, et al. Expert Opin Biol Ther. 2022 Jul;22(7):821-829. [2] Bruce IN, et al. Ann Rheum Dis. 2015;74 (9):1706–1713]. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>