tbuckley/cabot-search huggingface dataset:
Circadian variation of blood pressure and endothelial function in patients with essential hypertension
Authors: Yukihito Higashi, Keigo Nakagawa, Masashi Kimura, Kensuke Noma, Keiko Hara, Satoshi Sasaki, Chikara Goto, Tetsuya Oshima, Kazuaki Chayama, Masao Yoshizumi
Journal: Journal of the American College of Cardiology (2002)
Comparative Multivariate Analysis of Codon and Amino Acid Usage in Three Leishmania Genomes
Authors: Nutan Chauhan, Ambarish Sharan Vidyarthi, Raju Poddar
Journal: Genomics Proteomics & Bioinformatics (2011)

Multivariate analysis of codon and amino acid usage was performed for three Leishmania species, including L. donovani, L. infantum and L. major. It was revealed that all three species are under mutational bias and translational selection. Lower GC12 and higher GC3S in all three parasites suggests that the ancestral highly expressed genes (HEGs), compared to lowly expressed genes (LEGs), might have been rich in AT-content. This also suggests that there must have been a faster rate of evolution under GC-bias in LEGs. It was observed from the estimation of synonymous/non-synonymous substitutions in HEGs that the HEG dataset of L. donovani is much closer to L. major evolutionarily. This is also supported by the higher dN value as compared to dS between L. donovani and L. major, suggesting the conservation of synonymous codon positions between these two species and the role of translational selection in shaping the composition of protein-coding genes.
Nothing Too Much
Authors: 卞恺灵
Journal: New England Journal of Medicine (1928)

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Abstract 2526: Fetal Programming of Hypertension: Decreased Compliance and IGF-I Plasma Levels in Umbilical Arteries of Infants with Intrauterine Growth Restriction
Authors: Tilo Burkhardt, Christian M Matter, Christine Lohmann, Hao Cai, Thomas F Lüscher, Andreas H Zisch, Ernst Beinder
Journal: Circulation (2007)

Background : Epidemiological studies link intrauterine growth restriction (IUGR) to arterial hypertension in adulthood. Intrauterine stress may induce decreased arterial compliance that persists after birth, thus predisposing the individual for arterial hypertension in adult life. Methods and Results : We compared umbilical arteries from IUGR (n=13, &lt;5 th weight percentile) vs. appropriate for gestational age (AGA) infants (n=13) using structural and functional analyses. Vessel wall thickness and stiffness were determined in umbilical artery-derived vessel rings. Vessel wall elastin, the main determinant of arterial elasticity, was quantified by elastin extraction. Cord blood was assayed for growth factors known to modulate vessel wall matrix. IUGR infants had decreased umbilical artery compliance in vivo in terms of an increased resistance-index (P&lt;0.05). In parallel, the vessel wall area of umbilical arteries in the IUGR group was significantly smaller than in the AGA group (2.8 vs. 3.8 mm 2 , P&lt;0.05). Myographic measurements showed that maximal tension [mN/mm] as well as maximal force [mN] were both significantly increased in IUGR arteries compared with AGA arteries (P&lt;0.05). Serum levels of IGF-I, a regulator of elastin synthesis, were significantly lower in IUGR cord blood (P&lt;0.01) than in AGA cord blood. These IGF-I serum levels correlated significantly with maximum tension in umbilical arteries (P&lt;0.01). In parallel, we found a trend to reduced elastin content in the vessel wall of IUGR vessels. Conclusions : IUGR infants possess thinner and stiffer umbilical arteries than AGA infants. Low intrauterine IGF-I serum levels may account for reduced arterial elastin at birth, thereby providing a potential link to arterial hypertension in adulthood.
Abstract 3196: Regular Physical Exercise Training Induces Neovascularization in the Skeletal Muscle in Patients with Severe Chronic Heart Hailure
Authors: Robert Hoellriegel, Sandra Erbs, Axel Linke, Volker Adams, Marcus Sandri, Norman Mangner, Stephan Gielen, Rainer Hambrecht, Schuler Gerhard
Journal: Circulation (2008)
Abstract 5021: The Paradox of Gender in Long-Term Survival Following AMI: A Comparison of the 1995 and 2001 Minnesota Heart Survey Cohorts
Authors: Alan K Berger, Susan J Duval, Cheryl Barber, Lindsay Smith, Russell V Luepker
Journal: Circulation (2008)

Improved mortality following acute myocardial infarction (AMI) has been observed in recent decades. We sought to identify how improved adherence to standard pharmacologic therapies and widespread use of percutaneous coronary intervention (PCI) impact mortality in men (M) and women (W). The Minnesota Heart Survey (MHS) abstracted a random sample of all medical records from patients age 30 –74 hospitalized with an AMI in the Minneapolis metro area in 1995 and 2001. Hospital mortality was ascertained from the medical record and verified using death certificates. General linear models were used to compare the outcomes of M and W between the 1995 and 2001 surveys. Survival curves were estimated using Cox proportional hazard models incorporating demographic factors and baseline characteristics. We identified 1313 AMI patients (764 M, 549 W) in 1995 and 1518 AMI patients (630 M, 888 W) in 2001. W were younger in 2001 compared to 1995; there was no significant age difference in M. The prevalence of hypertension and diabetes in AMI patients increased between 1995 and 2001. The use of aspirin, beta-blockers and ACE inhibitors during hospitalization as well as coronary angiography and PCI significantly increased between 1995 and 2001. There was a significant decline in hospital length of stay for M (2.0 days) and W (1.5 days). There was a significant decline in 3-year adjusted mortality for M but a nonsignificant increase in mortality in W [Figure ]. Improved utilization of recommended AMI pharmacologic therapies and coronary revascularization between 1995 and 2001 in M and W have only translated into improved survival among M in a population-based study.
Abstract 690: Variability and Predictors of Patient Radiation Dose with Dual Source Cardiac CT: Implications for Future Algorithms to Reduce Patient Radiation Dose
Authors: Ron Blankstein, Rodrigo Pale, Khurram Nasir, Amar B Shah, Hiram Bezerra, Michael Bolen, Rajiv Gupta, Wilfred S Mamuya, Suhny Abbara, Thomas J Brady, Ricardo C Cury
Journal: Circulation (2008)

Intro : DSCT provides improved temporal resolution due to the simultaneous use of two x-ray sources &amp; detectors. Although use of two sources may increase radiation, the DSCT offers key mechanisms to reduce dose (i.e. pitch adaptation, tube current modulation (TCM) &amp; prospective triggering). Thus, our aim was to assess the patient radiation exposure associated with DSCT and identify variations based on the use of different scan related parameters. Methods : Prospective study of a single tertiary medical center where radiation and image quality related data was collected on 304 consecutive patients (pts) presenting for clinical CCT examination. Effective radiation dose was calculated by multiplying the dose-length product × (k=.017 mSv/mGy/cm). Image quality was rated on a subjective IQ score [1=poor to 4=excellent], as well as contrast (CNR) and signal-to-noise (SNR) ratios. Adjusted means of increased radiation dose were calculated based on linear regression models. Results: Among 304 consecutive studies (mean age 56.4, BMI 29.4 kg/m 2 , 37% Female), 60% were performed for coronary evaluation, 8% for CABG, 18% for pulmonary veins and 11% for aortic disease. The average radiation dose was 13.5±9.2mSv [range 0.5–55.5 mSv]. TABLE provides unadjusted and adjusted mean radiation dose for parameters which had a significant univariate association with radiation dose. Independent predictors of lower radiation included low kV, use of TCM, higher pitch, smaller scan length, and regular heart rhythm. Selected use of various TCM algorithms &amp; low KV resulted in no significant difference in IQ, CNR, or SNR. Conclusions : DSCT is associated with a wide range of patient radiation exposure. The variability in dose is due to both controllable parameters (i.e. use of TCM, low kV, scan length) as well as parameters that cannot be altered (i.e. irregular rhythm). These results suggest that individualizing scan protocols may result in lower radiation dose without compromising image quality. Table: Cardiac DSCT Parameters Affecting Patient Radiation Dose
Timing is more important than choice of agent
Authors: T. Sulkin
Journal: BMJ (1995)

technique, and outcome of peripheral thrombolysis for the past two years.2This is a continual process to provide a system for the national audit of peripheral arterial thrombolysis, and so far over 450 events of thrombolysis have been recorded.In these, only 13% of infusions were given with a pulse spray technique, in a median time of six hours (range 1-78 hours).Pulse spray lysis is certainly faster than conventional low dose techniques, but it requires expensive catheters and infusion systems.Other methods, such as high dose bolus thrombolysis and six hourly dose infusions, have also been reported to reduce infusion times without expensive equipment.34Personal communications with the manu- facturers of pulse spray infusion catheters also suggest that relatively few hospitals in Britain use the pulse spray technique.Little information is available on many of the techniques for peripheral thrombolysis, and low dose infusions remain the gold standard for many hospitals in Britain.
A new tissue acquisition technique in pancreatic cystic neoplasm: endoscopic ultrasound-guided through-the-needle forceps biopsy
Authors: Luca Barresi, Ilaria Tarantino, Dario Ligresti, Gabriele Curcio, Antonino Granata, Mario Traina
Journal: Endoscopy (2015)

A 46-year-old woman with diabetes mellitus type 2 was admitted for endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/B) because of the incidental diagnosis of a 5-cm pancreatic cystic lesion (PCL) in the pancreatic body, suspicious for pseudocyst ([Fig. 1]). The procedure was performed through the patient's stomach with a standard 19-gauge needle. FNA/B targeting the pancreatic cystic wall was followed by several bites with a through-the-needle forceps (mini biopsy forceps, 0.8 mm in diameter; Endo-flex GmbH, Voerde, Germany) ([Fig. 2] and [Fig. 3], [Video 1]).
Abstract 16010: A Novel Biodegradable Stent Design Applicable for Pediatric Use in Congenital Heart Disease : Bench Testing and Initial Results in a Rabbit Model
Authors: Surendranath R Veeram Reddy, Tre R Welch, Jian Wang, Frederic Bernstein, James A Richardson, Robert C Eberhart, Joseph M Forbess, Alan W Nugent
Journal: Circulation (2011)

INTRODUCTION: Biodegradable stents designed for use in infants would offer tremendous advantages by avoiding a permanent implant in a growing child. The bench testing and initial results of a coil ...
Prognostic Criteria for Hospice Eligibility
Authors: David A. Simpson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatal aortic hemorrhage after over-the-scope clipping and subsequent esophageal stenting for sealing of iatrogenic esophageal perforation
Authors: Joerg Lindenmann, Alfred Maier, Nicole Fink-Neuboeck, Freyja Smolle-Juettner
Journal: Endoscopy (2015)

Endoscopic fixation using over-the-scope clips (OTSCs) is mostly done to prevent migration of esophageal stents placed in the absence of a stenosis [1] [2] [3] [4]. Additional stenting of areas treated with OTSCs has not yet been described.
CONDITIONS TO BE DIFFERENTIATED IN THE ROENTGEN DIAGNOSIS OF PULMONARY TUBERCULOSIS
Authors: L H GARLAND
Journal: Annals of Internal Medicine (1948)

Article1 November 1948CONDITIONS TO BE DIFFERENTIATED IN THE ROENTGEN DIAGNOSIS OF PULMONARY TUBERCULOSISL. H. GARLAND, M.D.L. H. GARLAND, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-5-878 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe use of roentgenology as an aid in the diagnosis of chest disease is now standard medical practice. Conservative physicians, be they internists, radiologists or chest specialists, are well aware of the fact that the bacteriological origin of the disease which produces a shadow in the roentgenogram cannot be determined from the roentgenogram alone. This important fact is sometimes lost sight of, especially by enthusiastic proponents of mass chest roentgen-ray surveys.In order that physicians may have a convenient reference list of diseases, disorders and anomalies which may resemble pulmonary tuberculosis in the roentgenogram, that is, which may cast shadows... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Presented, by invitation, before the annual meeting of the American College of Physicians, San Francisco, April 19-23, 1948. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosisChanging pattern of tuberculosis controlIndustrial Hygiene Section 1 November 1948Volume 29, Issue 5Page: 878-880KeywordsPulmonary diseasesRadiologistsThorax ePublished: 1 December 2008 Issue Published: 1 November 1948 PDF downloadLoading ...
Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria–type cells
Authors: Xingmin Feng, Tatsuya Chuhjo, Chiharu Sugimori, Takeharu Kotani, Xuzhang Lu, Akiyoshi Takami, Hiroyuki Takamatsu, Hirohito Yamazaki, Shinji Nakao
Journal: Blood (2004)
Prevention of infection after TAC chemotherapy for node-positive breast cancer as an adjuvant therapy with or without ciprofloxacin
Authors: Y. Suh, C. Chun, S. Oh, B. Song, S. Jung
Journal: Journal of Clinical Oncology (2008)

613 Background: TAC (docetaxel, doxorubicin and cyclophosphamide) chemotherapy has been accepted as an adjuvant chemotherapy for the node positive breast cancer. But, moderate to severe adverse reactions, especially neutropenia, right after this regimen have been major hurdle for the wider enthusiasm. Until now, ciprofloxacin has been given to patients on completion of each cycle to prevent systemic infection. We tried to determine if ciprofloxacin is to be included in the post-chemotherapy medications or not to stop possible infection. Methods: We randomly assigned 100 patients into two groups between Jan. 2006 to Oct. 2007. Study group (A; n=50 patients, 300 cycles) was given prophylactic G-CSF (300 ug) from day 5 to day 10, and the control group (B; n=50, 300 cycles) was given G-CSF and ciprofloxacin (500 mg, orally twice daily) from day 5 to 10. We compared the incidence of infection and neutropenia prospectively. This study was reviewed by the IRB and informed consent from the patient should be compulsory for her to be included in this trial. Results: The incidence of infection in group A was 0.5% and in group B was 0.4% (p=0.14). The incidence of febrile neutropenia was 12% (A) versus 10% (B) (p=0.09). We couldn't find the significant differences in grade 4 neutropenia nor leukopenia after G-CSF with/without ciprofloxacin. Conclusions: The use of ciprofloxacin was not helpful to reduce systemic infection nor neutropenia after TAC chemotherapy. Even though larger number of patients should be enrolled to get the definite answer to delineate the protective role of ciprofloxacin against infection or neutropenia, we don't think that ciprofloxacin itself gives additional advantage to the patients having TAC chemotherapy to go through all cycles with less adverse reactions. No significant financial relationships to disclose.
Study of Sepsis in Surgical Wounds
Authors: S I HNATKO, G R MACDONALD, A E RODIN
Journal: JAMA (1963)

Published records of the frequency of wound sepsis are often unreliable sources of information on the general frequency of this complication because of unstandardized methods of reporting and because of the various views of different investigators as to what constitutes sepsis. A method of infection reporting, its study and analysis are outlined. A survey of postoperative infections by this method for the years 1959, 1960 and 1961 revealed infection rates of 2.02%, 1.20% and 1.14%, respectively. For the same period the percentages of wound infections caused by Staph. aureus were 83.06%, 69.8% and 51.8%, respectively. The most prevalent phage types were 55/53/54 and 52/80/81/82, although types 80/81/82 and 80 were also involved. Infections with Gram-negative organisms were encountered more often in 1961 than in 1959. The majority of these were of mixed type, and followed abdominal surgery.There is need for more comprehensive study and analysis of postoperative wound sepsis and its complications. It was apparent from this study that, statistically, a relatively low rate of postoperative infections may mask a high rate following a specific surgical procedure.
Abstract 13956: High Risk Patients with ST-segment Elevation Myocardial Infarction on The Global Registry of Acute Coronary Events (GRACE) Risk Score Have Higher Index of Microcirculatory Resistance Values
Authors: Yuma Kurozumi, Noritoshi Ito, Shinsuke Nanto, Yasuji Doi, Mai Hatano, Daisuke Tonomura, Tomoaki Natsukawa, Noriaki Yamada, Ken-ichiro Okada, Hirotaka Sawano, Yasuyuki Hayashi, Tatsuro Kai, Toru Hayashi
Journal: Circulation (2010)

Background: Index of microcirculatory resistance (IMR) has been proposed as a novel predictor of microvascular dysfunction and recovery of left ventricular function after ST-segment elevation myocardial infarction (STEMI). However, the impact of IMR values on mortality risk in STEMI remains uncertain. One previous study showed high risk patients with acute coronary syndromes on the Global Registry of Acute Coronary Events (GRACE) risk score benefits more from early-intervention (coronary angiography≤24 hours) than low-to-intermediate risk. Objective: We investigated whether high risk patients with ST-segment elevation myocardial infarction on the GRACE risk score have higher IMR values. Methods and Results: We investigated the association between the GRACE risk score for predicting in-hospital mortality and IMR after primary percutaneous coronary intervention (PCI) in patients with STEMI. Seventy-one consecutive patients with STEMI (mean age: 65±11 years, male: 59, female: 12) were divided into two groups...
Abstract 12745: Is Myocardial Bridging Truly Benign? Impact of Myocardial Bridging Induced Arterial Compression on Atherosclerotic Plaque Formation
Authors: Ryotaro Yamada, Ingela Schnittger, Jennifer A Tremmel, Shin Lin, Paul G Yock, Peter J Fitzgerald, Yasuhiro Honda
Journal: Circulation (2012)

Introduction: A myocardial bridge (MB) that partially covers the left anterior descending coronary artery (LAD) sometimes leads to atherosclerotic plaque formation proximal to the MB because of hem...
Inhaled Cyclosporine For The Treatment Of Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation (HSCT) Or Lung Transplantation
Authors: Nicole Gormley, Catalina Ramos, Robert Reger, Margaret Tropea, Xin Tian, Elena Cho, Debra Reda, Michael Terrin, Leigh Samsel, Millie Whatley, James Shelhamer, Clara C. Chen, Minoo Battiwalla, A. John Barrett, Tim Corcoran, Aldo Iacono, J. Philip McCoy, Anthony Suffredini, Richard W. Childs
Journal: Blood (2013)
CLINICAL APPROACH TO ALLEGED TRAUMATIC DISEASE
Authors: Leopold Brahdy, Samuel Kahn
Journal: Annals of Internal Medicine (1943)

Article1 April 1943CLINICAL APPROACH TO ALLEGED TRAUMATIC DISEASELEOPOLD BRAHDY, M.D., SAMUEL KAHN, M.D.LEOPOLD BRAHDY, M.D.Search for more papers by this author, SAMUEL KAHN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-4-491 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEvery part of the body is daily subject to all kinds of minor traumata, of which the individual is usually only vaguely conscious. When, following any such trauma, undue symptoms appear, the patient promptly recalls the recent injury and tends to attribute to it the condition from which he suffers. If the accident was an unusually dramatic one, a patient will be even more convinced that his condition resulted therefrom, even though it occurred long before the symptoms became manifest.In eliciting the history in such a case, it is important to remember that the patient's opinion as to the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LEOPOLD BRAHDY, M.D.; SAMUEL KAHN, M.D.Affiliations: New York, N. Y.*Received for publication February 8, 1943. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1943Volume 18, Issue 4 Page: 491-499 ePublished: 1 December 2008 Issue Published: 1 April 1943 PDF downloadLoading ...
Mouse podocytes in culture express aminopeptidase A (APA), but not other components of the renin-angiotensin system (RAS)
Authors: S. Mentzel, J.P.H.F. van Son, H.B.P.M. Dijkman, A.S. de Jong, M.J.M. Bosch, J.F.M. Wetzels, R.A.P. Koene, K.J.M. Assmann
Journal: Kidney International (1996)