tbuckley/cabot-search huggingface dataset:
Fortnightly review : the diagnosis of pulmonary embolism
Authors: T. Fennerty
Journal: BMJ (1997)

Currently, clinicians have to make decisions about how to manage pulmonary embolism on the basis of imperfect tests and assessment of odds. Management protocols that inevitably result in large numbers of patients being referred for angiography are unhelpful. Management decisions based on assessment of odds and investigation of leg veins will inevitably result in some patients who have survived a pulmonary embolus being left untreated. Current evidence suggests that for most patients this is probably not important, the clear exception being those patients with underlying cardiorespiratory disease.
The Practitioner's Guide to the Diagnosis and Treatment of Diseases of Women.
Authors: Gustavus Maximilian Blech
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Self-Propelled Vehicles. A Practical Treatise on the Theory, Construction, Operation, Care and Management of all Forms of Automobiles.
Authors: Homans, James E. , b.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1444: Reversal of Sepsis-induced Contractile Dysfunction by Targeting Cardiac TnI Phosphorylation
Authors: Melanie Marshall, Joanne Layland, Narayana Anilkumar, Robert S Haworth, Jonathan C Kentish, Ajay M Shah, Alison C Cave
Journal: Circulation (2006)

Systemic sepsis is associated with an intrinsic impairment of cardiomyocyte contraction due in part to a decrease in myofilament Ca2+ sensitivity associated with a sustained increase in cardiac tro...
Hypoxia and Cold.
Authors: John R. Sutton, Charles S. Houston, Geoff Coates
Journal: Annals of Internal Medicine (1988)

Foreword Acknowledgments Contributors Part I: Extreme Environments: An Overview Part II: Interactions Between Cold and Hypoxia Part III: Oxygen Delivery in Cold, Exercise and Hypoxia Part IV: The Lungs in Cold and Hypoxia: The Circulation The Lungs in Cold and Hypoxia: The Airways Part V: Pathophysiology, Treatment, and Prevention of Hypothermia Part VI: Frostbite Part VII: Extreme Environments: Coping Strategies of Animal and Humans Part VIII: Physiology of Elite Mountaineers Part IX: Factors Limiting Performance at Extreme Altititude Abstracts Index
Predicting psychosocial well-being in head and neck cancer (HNC)
Authors: K. A. Dwyer, B. A. Murphy, A. J. Cmelak, C. Chung, B. B. Burkey, J. L. Netterville, W. Yarbrough, M. R. McDowell
Journal: Journal of Clinical Oncology (2004)

5538 Background: Head and Neck cancer is associated with numerous tumor and treatment related sequelae that affect function, quality of life and psychosocial well-being. Coping styles may affect these outcomes. We conducted a cross sectional, descriptive study of HNC patients across the trajectory of diagnosis and treatment to examine the relationship between coping patterns and biopsychosocial outcomes. Methods: 99 patients completed the following: the Vanderbilt Multi-dimensional Coping Inventory, the Vanderbilt Head and Neck Symptom Survey, the EORTC HN 35, the Center for Epidemiology-Depression, the Impact of Illness Events Scale, the Psychological Vulnerability Scale, and the Brief Religious Coping Scale. Results: Patient characteristics: mean age - 55 (range 21–89 years), educational level 13 years (7–21), 75% male, 93% white, 70% married, 41% employed, 12% currently using a feeding tube. Using hierarchical cluster analysis, two distinctive coping profiles were identified. Cluster 1 used active coping strategies; cluster 2 used low levels of coping strategies. Differences between the two clusters were noted in: use of planful problem solving, distraction, wishful thinking, positive reframing, acceptance and turning to religion. The groups did not differ in the overall report of symptoms, depressive symptoms, perceived health competence or their overall rating of well-being. Separate regression analyses were conducted to identify the best predictors of well-being within clusters. In cluster 1, weight loss and negative religious coping explained 58% of the variance in well-being. For cluster 2, symptom burden, depressed mood, and perceived health competence explained 78% of the variance in well-being. Conclusions: Unlike patients who use "active coping" methods, the global well being of patients with minimal coping skills is affected by symptom burden. Interventions to enhance coping strategies in this group of patients should be designed in order to minimize this effect. No significant financial relationships to disclose.
Handbook for the Bio-Chemical Laboratory, including methods of preparation and numerous tests arranged alphabetically.
Authors: John Alfred Mandel
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Therapeutics. A Handbook on the Special Treatment of Internal Disease.
Authors: Alfred Careno Croftan
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Teeth. Their Diagnosis and Treatment.
Authors: John Albert Marshall
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A multicenter phase 2 consortium (P2C) study of triapine in patients (pts) with advanced adenocarcinoma of the pancreas
Authors: D. L. Groteluschen, M. R. Mahoney, H. C. Pitot, D. Laheru, J. Kolesar, J. P. Thomas, C. Erlichman, K. D. Holen
Journal: Journal of Clinical Oncology (2006)

14118 Background: Triapine is a small molecule iron chelator that has been shown to inhibit ribonucleotide reductase (RR) at the M2 subunit. Early trials suggested activity in pancreatic cancer. The P2C initiated a study of single agent Triapine as both first-line therapy and for pts with gemcitabine-refractory disease. Correlatives included: pharmacokinetics, MDR polymorphisms, and the effects of Triapine on cell cycle and electron paramagnetic resonance spectroscopy (EPR). Methods: Standard eligibility criteria were used, however, pts with G6PD deficiency were excluded. Triapine was given 96 mg/m 2 IV over 2 hours, days 1–4 and 15–18, repeated q 28 days. Primary goals - evaluate survival (S) at 6 mos (previously untreated pts) and 4 mos (refractory pts). Interim analyses were planned when 28 previously untreated and 20 refractory pts were enrolled. Results: 14 eligible pts were enrolled in 10 mos (13 refractory, 9 male). The previously untreated pt received only 1 cycle secondary to progressive disease. Of the 13 refractory pts, 7 pts received at most 2 cycles; 6 received 1. Disease progression precluded further treatment in 11 pts. 6 pts had Gr 4 toxicities at least possibly related to drug, including: neutropenia-4, hyperkalemia-1, hyponatremia-1, leukopenia-1, thrombocytopenia-1, hypophosphatemia-1. 6 pts had a Gr 3 fatigue. One refractory patient expired on study. No responses were seen. Estimated 4 mos S in refractory pts is 16% (95% CI 3–94). EPR studies showed that Triapine led to a loss of the RR tyrosine radical EPR signal. Conclusions: Enrollment was suspended due to excess toxicity and lack of activity in pts refractory to gemcitabine. Correlative studies confirm the mechanism of action of Triapine as a chelating agent on RR. Supported by NCI Grant N01 CM17104 and the NCI Translational Research Fund. No significant financial relationships to disclose.
Applied Electrocardiography. An Introduction to Electrocardiography for Physicians and Students.
Authors: Aaron Ephim Parsonnet, Albert Solomon Hyman
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The importance of the rites of passage in assigning semantic structures to autobiographical memory
Authors: Oana Benga, Bogdan Neagota, Ileana Benga
Journal: Behavioral and Brain Sciences (2015)

As cultural anthropologists, we noticed an unexpected and interesting convergence of the therapeutic practices suggested in the target article and the rites of passage occurring across multiple societies, as individuals make the transition from one significant age or status to another.
Growth Inhibitory Function Of a Novel T-LAK Cell-Originated Protein Kinase Inhibitor On FLT3-ITD Positive Acute Myeloid Leukemia (AML) Cells
Authors: Houda Alachkar, Jae-Hyun Park, Makoto Nakakido, Alex Wood, Gordana Raca, Yo Matsuo, Wendy Stock, Yusuke Nakamura
Journal: Blood (2013)
The Pathology of Limb Ischaemia.
Authors: James Henry Dible
Journal: Annals of Internal Medicine (1967)

4Book reviews seven cover the ordinary types that one commonly encounters; epidermoid carcinoma, small cell, anaplastic carcinoma, adenocarcinoma, large cell carcinoma, com- bined epidermoid and adenocarcinomas, carcinoids, and bronchial gland tumours.The other seven comprise uncommon tumours and include pleural mesotheliomas.These groups are usually subdivided into three or four types.After listing the tumour types that they accept, the authors give six pages of short descriptions of the characters of the individual tumours and include short notes on their anatomical and clinical characters.This is followed by a description of the combined staining method they have used and finally 40 colour photo- micrographs to illustrate the tumour types.The latter are, with a few obvious exceptions, of one standard magnification and are therefore comparable.These figures measure 11 x 7l5 cm. and clearly illustrate the tumour types listed.This is a valuable little monograph.Lung tumours are amongst the commonest we encounter and it is particu- larly useful to have a standardized nomenclature that can be shared by clinicians and pathologists and that will enable us to communicate our findings with precision to our colleagues.
Increase of creatine kinase value (CK) correlates with muscoloskeletal complaints (MSC) in GIST patients during imatinib therapy
Authors: P. Allione, G. Grignani, S. Aliberti, D. Rota Scalabrini, F. Carnevale Schianca, A. Capaldi, R. Vormola, D. Caravelli, A. Galla, M. Aglietta
Journal: Journal of Clinical Oncology (2006)

9509 Background: MSC-pain, muscle cramps, myalgias, arthralgias-are commonly associated with imatinib therapy, affecting 25% to 50% of patients. The cause is still unknown. MSC is usually mild to moderate and manageable without reduction of imatinib dose. Calcium and magnesium supplements have occasionally provided some relief. It is rather difficult to quantify MSC and patients who deserve interruption or analgesia on the base of symptoms alone. Since CK values are commonly elevated during imatinib therapy, we evaluate CK as a surrogate marker of MSC. Methods: Since 2002, 40 patients (pts) affected by advanced GIST were treated with imatinib 400 mg/day until progressive disease when dosage would be increased to 800 mg/day. Toxicity (CTC 2.0) and blood chemical values were prospectively collected on a monthly basis. Results: G1–2 MSC was observed in 22 pts (55%). We had to stop therapy in one patient only for one week because of uncontrolled MSC. CK was abnormal in 23 pts (57%). 13 pts (32%) had CK values up to twice upper normal value (UNV); 8 pts (20%) above thrice the UNV and 2 pts (5%) above 5 times the UNV. Among 10 pts having MSC G2, seven had CK above thrice UNV. The 2 pts experiencing MSC G3 had also CK above 5 times UNV. Conclusions: CK increase reflects MSC in a great majority of the patients who experienced this rather common imatinib side effect. To consider CK into standard clinical chemistry work up of patients on imatinib allows clinicians to add an objective measure of MSC. No significant financial relationships to disclose.
Action on AIDS: National Policies in Comparative Perspective
Authors: Barbara A. Misztal, David Moss
Journal: Annals of Internal Medicine (1991)

Introduction by David Moss and Barbara A. Misztal AIDS Policies and Practices in the United States by Michael Quam and Nancy Ford Responding to AIDS in Brazil by Richard G. Parker AIDS Policy in France: Biomedical Leadership and Preventative Impotence by Michael Pollak AIDS in Belgium: Africa in Microcosm by Michel Hubert AIDS in West Germany: Coordinating Policy in a Federal System by Michael Pollak AIDS in Italy: Emergency in Slow Motion by David Moss AIDS in Poland: The Fear of Unmasking Intolerance by Barbara A. Misztal AIDS in Australia: Diffusion of Power and Making of Policy by Barbara A. Misztal AIDS, Development and the Limitations of the African State by Alfred J. Fortin Conclusion by Barbara A. Misztal and David Moss Bibliographic Essay Index
Prognostic prediction and preoperative staging of F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) in patients with gastric cancer
Authors: J. Kim, S. Choi, M. Lee, I. Hyun, Y. Hur, H. Kim, Y. Shin, S. Shin, Y. Kim, C. Kim
Journal: Journal of Clinical Oncology (2008)

15530 Background: The aim of this study was to evaluate the utility of F-18 FDG PET for preoperative staging and prognostic prediction of gastric adenocarcinoma. Methods: We evaluated 153 consecutive patients admitted for gastric adenocarcinoma from January 2004 through November 2007. All patients underwent routine staging procedures, including complete history taking, physical examination, laboratory tests, upper GI endoscopy, and spiral CT of the abdomen and pelvis. CT scan was reviewed for extent of primary tumor, presence of perigastric infiltration, lymph node enlargement and metastatic lesion. Surgical staging was done in accordance to the American Joint Committee on Cancer (AJCC) 6th edition. For quantitative PET analysis, the FDG uptake of every detected lesion was measured by the standardized uptake value (SUV). Results: The median age of 153 patients was 62 (range: 24–85), 101 of whom (66.0%) underwent laparotomy. The primary site of the tumor demonstrated increased SUV uptake in 129 of 153 patients (sensitivity, 84.3%) on PET, with a median SUV of 4.33 (range: 1.33–27.25). The comparison of FDG uptake with clinicopathologic features showed significant correlation of FDG uptake to differentiation (P<.001), histologic type (P=.001) and lymphatic invasion (P<0.0001). The SUV showed no significant correlation to location, Borrmann type, Lauren classification, vascular and perineural invasion, T stage, N stage, and tumor size. The SUV of primary tumor was significantly different between tumors larger than 30mm and those smaller than 30mm (P<.001). For the diagnosis of nodal involvement, PET was inferior in sensitivity (42.8% vs. 75.0%) and superior in specificity (89.3% vs. 53.8%) to CT. PET had additional diagnostic value in 24 (15.7%) of 153 patients enabling it to upstage. Among 8 patients with pathology-proven peritoneal carcinomatosis, the findings of CT were suggestive of peritoneal seeding in 7, while the findings of PET were in 6. Among 9 patients with suspicious adrenal metastasis on CT, 2 were also suspected on PET. One of them had benign pathology, and the other was not confirmed. Conclusion: FDG-PET improves the preoperative TNM staging of gastric adenocarcinoma. No significant financial relationships to disclose.
How decision support tools help define clinical problems
Authors: Frank Sullivan, Jeremy C Wyatt
Journal: BMJ (2005)

The patient, Mr Evans, presented with headaches and early morning wakening (dealt with in article of 24 September) as the main reason for his consultation.This article, however, discusses how informatics resources can be used to consider issues other than the presenting problem.The Stott and Davies model of the consultation indicates that three other areas of the interaction should be considered.x Management of continuing problems-The patient's diabetes may be contributing to the overall picture.x Opportunistic health promotion-Ask screening questions about alcohol use and measure the patient's blood pressure.x Modification of help seeking behaviours-Discuss issues relevant to self care and when to attend for health checks for established or potential problems. Management of continuing problems Awareness of problemsSometimes doctors and patients are not aware of relevant problems.Issues that are apparent to one person may not be apparent to the other.In Mr Evans's case the diabetes is known to doctor and patient.The alcohol problem is, perhaps dimly, apparent to Mr Evans.The high blood pressure reading is something that only the doctor is aware of initially.Neither doctor nor patient is aware of the depression at the beginning of the consultation, but information conveyed before, or during, the consultation may alter that.When a health professional realises that he or she is aware of an issue that the patient is not, the matter can be remedied.It is more difficult if the patient is aware of an issue that is relevant, but is unwilling to divulge it.Even more difficult is a situation where neither patient nor doctor is aware of a problem that may be relevant to the patient's problems (see Johari Window).Electronic prompts to bring up such hidden issues are being incorporated into clinical systems, and are increasingly effective.