AB1354 SPANISH NATIONAL MULTICENTER REGISTRY OF PREGNANCY IN SYSTEMIC AUTOINMUNE RHEUMATIC DISEASES
Authors: D. Fernández Fernández, I. L. Mamani Velarde, I. Altabás González, A. Comins-Boo, V. Martinez Taboada, J. Martínez-Barrio, E. Rodríguez Almaraz, E. De La Mata, M. Galindo-Izquierdo, B. P. Magallares, H. Corominas, M. E. Ruiz Lucea, M. Enjuanes-Noguero, J. A. Martinez Lopez, A. A. García Fernández, E. Couceiro-Naveira, A. Concheiro-Guisán, J. J. Alegre Sancho, A. Taberner-Cortés, S. Garrote-Corral, M. J. Garcia-Villanueva, I. Añón Oñate, I. Carrión-Barberà, T. C. Salman-Monte, C. Sieiro Santos, S. Gómez Sabater, R. Caño Alameda, P. Vela Casasempere, J. M. Pego-Reigosa
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> A large part of systemic autoimmune rheumatic diseases (SARD) affect women of childbearing age [1] so coincidence/concurrence of the disease and pregnancy is common. It is therefore important to know the clinical and therapeutical characteristics of this group of patients to improve their approach, planning and reducing the risk of maternal-fetal complications, in addition to achieving a greater understanding of the relationship between SARDs and pregnancy. <h3>Objectives:</h3> To increase the knowledge about the evolution of pregnancy in patients with SARDs through the creation of a National Multicenter Prospective Registry of patients treated in the Rheumatology services of Spain, under conditions of usual clinical practice and taking into account the EULAR recommendations [2]. To describe the characteristics of pregnant patients with different SARDs. To describe the characteristics and evolution of the disease and the different treatments used during pregnancy of women with SARDs. To describe the maternal-fetal complications during pregnancy, their predictive factors, the characteristics of the newborns and their development during the first two years of life. <h3>Methods:</h3> This is a prospective observational multicenter study with participation of pregnant women with SARDs followed in specialized clinics of Rheumatology and Obstetrics. Data were collected from the patients at baseline (preconception visit), at the time of confirmation of the pregnancy and, subsequently, in each trimester and after delivery. The mother and child were assessed every 6 months during the first two years of life (Table 1). <h3>Results:</h3> So far, 11 hospital centers from Spain have participated. Data from 107 women with SARDs and gestational desire were collected from January 2019 to October 2023. Dated October 2023, a preliminary descriptive analysis of the patients included in the registry is carried out (Tables 2 and 3). The inclusion of patients and their children remains open. <h3>Conclusion:</h3> This national registry is constituted as a tool with a huge potential for future research in the field of SARDs and pregnancy, providing clinically relevant and reliable information, in line with the EULAR Recommendations (2), under conditions of daily clinical practice. <h3>REFERENCES:</h3> [1] Seoane-Mato D, Sánchez-Piedra C, Silva-Fernández L, et al. Prevalence of rheumatic diseases in adult population in Spain (EPISER 2016 study): Aims and methodology. Prevalencia de enfermedades reumáticas en población adulta en España (estudio EPISER 2016). Objetivos y metodología. Reumatol Clin (Engl Ed). 2019;15(2):90-96. [2] Meissner Y, Fischer-Betz R, Andreoli L, et al. EULAR recommendations for a core data set for pregnancy registries in rheumatology. Ann Rheum Dis. 2021;80(1):49-56.DOI:10.1136/annrheumdis-2020-218356. <h3>Acknowledgements:</h3> Project financed by the Carlos III Health Institute through the Health Research Fund (PI21/01894) and European Regional Developement Funds (ERDF). <h3>Disclosure of Interests:</h3> <b>None declared.</b>