tbuckley/cabot-search huggingface dataset:
Ambient air pollution exposure and adult asthma incidence: a systematic review and meta-analysis
Authors: Spencer Lee, Derek Tian, Rose He, Jacquelyn J Cragg, Chris Carlsten, Amanda Giang, Prubjot K Gill, Kate M Johnson, Emily Brigham
Journal: The Lancet Planetary Health (2024)

Ambient (outdoor) air pollutant exposures have emerged as a plausible risk factor for incident childhood asthma. However, the effect of ambient air pollutant exposures on risk of incident adult asthma is unclear. We aimed to investigate associations between specific ambient air pollutants and the risk of incident adult asthma.
Indigenous Elders' voices on health-systems change informed by planetary health: a qualitative and relational systems mapping inquiry
Authors: Nicole Redvers, Felix Lockhart, John B Zoe, Rassi Nashalik, Denise McDonald, Gladys Norwegian, Jamie Hartmann-Boyce, Sarah Tonkin-Crine
Journal: The Lancet Planetary Health (2024)

Indigenous Peoples and their knowledge systems are increasingly being looked to for solutions regarding climate change, including within clinical health-care settings. Indigenous Elders specifically are noted knowledge keepers within their communities and are often looked to with great respect for their Land-based knowledges as they pertain to planetary health approaches. We sought to explore the views of health-systems change informed by planetary health within the circumpolar north from the perspective of Indigenous Elders. We held a sharing circle, in which Elders identified four interconnected themes following a cyclical pattern that were also depicted with relational systems mapping, including the past and how we got here, where we are now, where we need to go in the future, and our reflections. Our findings showed that any concepts related to planetary health that are discussed within health systems cannot be disconnected from the context around them. Overall, health systems were stated to be currently devoid of any environmental context or consideration.
The role of vector population variation and climate in Zika virus transmission patterns in Africa: a modelling study
Authors: Jamie M Caldwell, Louis Lambrechts, Noah H Rose
Journal: The Lancet Planetary Health (2024)

Zika virus (ZIKV) outbreaks have raised major global health concerns recently, yet reported outbreaks are rare in Africa, where ZIKV was first discovered. Recent studies on Aedes aegypti, the mosquito that transmits ZIKV, might explain this phenomenon. The Ae aegypti subspecies present in Africa shows lower preference for biting humans and reduced susceptibility to ZIKV infection compared with the subspecies distributed outside Africa. Alternatively, climate might strongly limit transmission as it affects multiple traits of ZIKV and the mosquito vector.
Intersections between climate change and antimicrobial resistance: a systematic scoping review
Authors: Bianca van Bavel, Lea Berrang-Ford, Kelly Moon, Fredrick Gudda, Alexander J Thornton, Rufus F S Robinson, Rebecca King
Journal: The Lancet Planetary Health (2024)

Climate change and antimicrobial resistance (AMR) present crucial challenges for the health and wellbeing of people, animals, plants, and ecosystems worldwide, yet the two are largely treated as separate and unrelated challenges. The aim of this systematic scoping Review is to understand the nature of the growing evidence base linking AMR and climate change and to identify knowledge gaps and areas for further research. We conducted a systematic search of the peer-reviewed literature in Scopus, Web of Science, and PubMed on 27 June, 2022. Our search strategy identified and screened 1687 unique results. Data were extracted and analysed from 574 records meeting our inclusion criteria. 222 (39%) of these reviewed articles discussed harmful synergies in which both climate change and AMR exist independently and can interact synergistically, resulting in negative outcomes. Just over a quarter (n=163; 28%) of the literature contained general or broad references to AMR and climate change, whereas a fifth (n=111; 19%) of articles referred to climate change influencing the emergence and evolution of AMR. 12% of articles (n=70) presented positive synergies between approaches aimed at addressing climate change and interventions targeting the management and control of AMR. The remaining literature focused on the shared drivers of AMR and climate change, the trade-offs between climate actions that have unanticipated negative outcomes for AMR (or vice versa), and, finally, the pathways through which AMR can negatively influence climate change. Our findings indicate multiple intersections through which climate change and AMR can and do connect. Research in this area is still nascent, disciplinarily isolated, and only beginning to converge, with few documents primarily focused on the equal intersection of both topics. Greater empirical and evidence-based attention is needed to investigate knowledge gaps related to specific climate change hazards and antimicrobial resistant fungi, helminths, protists, and viruses.
Publisher Correction: Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders
Authors: Zhen Xia, Qihan Jin, Zhilin Long, Yexuan He, Fuyi Liu, Chengfang Sun, Jinyang Liao, Chun Wang, Chentong Wang, Jian Zheng, Weixi Zhao, Tianxin Zhang, Jeremy N Rich, Yongdeng Zhang, Longxing Cao, Qi Xie
Journal: Nature Biomedical Engineering (2024)
Antibiotic-perturbed microbiota and the role of probiotics
Authors: Hania Szajewska, Karen P. Scott, Tim de Meij, Sofia K. Forslund-Startceva, Rob Knight, Omry Koren, Paul Little, Bradley C. Johnston, Jan Łukasik, Jotham Suez, Daniel J. Tancredi, Mary Ellen Sanders
Journal: Nature Reviews Gastroenterology & Hepatology (2024)
Interdisciplinary perspectives on the co-management of metabolic dysfunction-associated steatotic liver disease and coronary artery disease
Authors: Jacob J Gries, Jeffrey V Lazarus, Paul N Brennan, Mohammad S Siddiqui, Giovanni Targher, Chim C Lang, Salim S Virani, Carl J Lavie, Scott Isaacs, Juan Pablo Arab, Kenneth Cusi, Chayakrit Krittanawong
Journal: The Lancet. Gastroenterology & hepatology (2024)
Climate and health education in public health schools worldwide during 2023–24: a survey
Authors: Cecilia Sorensen, Danielly Magalhães, Nicola Hamacher, James K Sullivan, Hannah N W Weinstein, Ana-Catarina Pinho-Gomes, Dorothy Biberman, Holly Donaldson, Ingrid Gómez-Duarte, John Middleton, Laura Magaña, Manuel Urbina, Margaret Kaseje, Nora Cascante-Flores, Rajendra Surenthirakumaran, Rebecca Ivers, Rocío Sáenz, Tara Tai-Wen Chen, Wendy Lopez, Marina Romanello, Ying Zhang
Journal: The Lancet Planetary Health (2024)

Public health professionals are crucial in implementing health-promoting climate change adaptation and mitigation measures, yet climate education is inconsistently integrated into public health curricula worldwide. We aimed to assess the proportion of institutions that provided public health degrees with climate and health education, the annual number of students trained in climate and health, and the extent to which students had climate and health knowledge during 2023-24.
Development, validation, and prognostic evaluation of LiverPRO for the prediction of significant liver fibrosis in primary care: a prospective cohort study
Authors: Katrine P Lindvig, Katrine H Thorhauge, Johanne K Hansen, Maria Kjærgaard, Camilla D Hansen, Stine Johansen, Ellen Lyngbeck, Mads Israelsen, Peter Andersen, Katrine T Bech, Nikolaj Torp, Helle L Schnefeld, Sönke Detlefsen, Sören Möller, Isabel Graupera, Morten B Trelle, Steen Antonsen, Rebecca Harris, Line L Kårhus, Kirsten S Bjørnsbo, Charlotte Brøns, Torben Hansen, Andreas Geier, Heiner Wedemeyer, Stefan Zeuzem, Jörn M Schattenberg, Pere Ginès, Indra Neil Guha, Aleksander Krag, Maja Thiele
Journal: The Lancet. Gastroenterology & hepatology (2024)
Health outcomes, environmental impacts, and diet costs of adherence to the EAT-Lancet Diet in China in 1997–2015: a health and nutrition survey
Authors: Hongyi Cai, Elise F Talsma, Zhiyao Chang, Xin Wen, Shenggen Fan, Pieter Van't Veer, Sander Biesbroek
Journal: The Lancet Planetary Health (2024)

In 2019, the EAT-Lancet Commission proposed a global reference dietary pattern. Although research on the EAT-Lancet reference diet and its associations with mortality, cardiovascular disease, type 2 diabetes, dietary environmental impacts, and cost of diets is increasing, studies done in low-income and middle-income countries remain scarce. This study aimed to assess the health outcomes, environmental impacts, and dietary costs of adherence to the EAT-Lancet reference diet in China.
Planetary Health Research Digest
Authors: Cahal McQuillan
Journal: The Lancet Planetary Health (2024)

Climate migration refers to migration driven by the impact of sudden weather events (eg, hurricanes and floods) or gradual climate-exacerbated disasters (eg, rising temperatures and fluctuating rainfall). The frequency and intensity of weather shifts such as these is expected to increase as a result of anthropogenic climate change, which will likely exacerbate the ongoing global migration crisis. In their new study, Julia Li Zhu (San Diego State University, CA, USA) and colleagues delve into the specifics and examine how extreme weather influenced undocumented migration between Mexico and the USA between 1992 and 2018.
The impact of natural climate variability on the global distribution of Aedes aegypti: a mathematical modelling study
Authors: Alexander R Kaye, Uri Obolski, Lantao Sun, William S Hart, James W Hurrell, Michael J Tildesley, Robin N Thompson
Journal: The Lancet Planetary Health (2024)

Aedes aegypti spread pathogens affecting humans, including dengue, Zika, and yellow fever viruses. Anthropogenic climate change is altering the spatial distribution of Ae aegypti and therefore the locations at risk of vector-borne disease. In addition to climate change, natural climate variability, resulting from internal atmospheric processes and interactions between climate system components (eg, atmosphere-land and atmosphere-ocean interactions), determines climate outcomes. However, the role of natural climate variability in modifying the effects of anthropogenic climate change on future environmental suitability for Ae aegypti has not been assessed fully. In this study, we aim to assess uncertainty arising from natural climate variability in projections of Ae aegypti suitability up to the year 2100.
Estimating the burden of temperature-related low birthweight attributable to anthropogenic climate change in low-income and middle-income countries: a retrospective, multicentre, epidemiological study
Authors: Zhenghong Zhu, Tuantuan Zhang, Tarik Benmarhnia, Xin Chen, Huailin Wang, Maimaitiminjiang Wulayin, Luke D Knibbs, Song Yang, Lianlian Xu, Cunrui Huang, Qiong Wang
Journal: The Lancet Planetary Health (2024)

Pregnant individuals are particularly susceptible to non-optimal temperatures due to their physiological status. Moreover, pregnancy is a crucial period for programming fetal health. Quantifying the impact of non-optimal temperature exposure and the contribution of anthropogenic climate change is crucial for mitigating and adapting to climate-related health risks. However, this has not been thoroughly studied in pregnant individuals in low-income and middle-income countries (LMICs).
Somebody has to move first
Authors: None The Lancet Planetary Health
Journal: The Lancet Planetary Health (2024)

It is abundantly clear from the science and from people's experience of an increasingly unstable, more polluted environment globally, that substantial and rapid action is needed to transition to more regenerative and sustainable ways of living. While we have ambitious global targets to reduce greenhouse gas (GHG) emissions and biodiversity loss, and there are some good individual actors, global politics has largely failed to deliver on action this year.
Estimating the effect of annual PM2·5 exposure on mortality in India: a difference-in-differences approach
Authors: Suganthi Jaganathan, Massimo Stafoggia, Ajit Rajiva, Siddhartha Mandal, Shweta Dixit, Jeroen de Bont, Gregory A Wellenius, Kevin J Lane, Amruta Nori-Sarma, Itai Kloog, Dorairaj Prabhakaran, Poornima Prabhakaran, Joel Schwartz, Petter Ljungman
Journal: The Lancet Planetary Health (2024)

In 2019, the Global Burden of Diseases, Injuries, and Risk Factors Study attributed 0·98 million deaths to ambient air pollution in India based on potentially inappropriate exposure-response functions from countries with low air pollution levels. Instead, using data from India, we investigated long-term exposure to PM
We're living through a planetary health crisis: health guidelines must consider planetary health
Authors: Thomas Piggott, Grigorios I Leontiadis, Alina Herrmann, Karolina Anna Scahill, Josep M Antó, Jodi D Sherman, Pablo Alonso-Coello, Ignacio Neumann, Holger Schünemann, Fiona A Miller
Journal: The Lancet Planetary Health (2024)
The potential for reducing greenhouse gas emissions through disease prevention: a secondary analysis of data from the CREDENCE trial
Authors: Benjamin Talbot, Robert A Fletcher, Bruce Neal, Megumi Oshima, Fiona Adshead, Keith Moore, Forbes McGain, Scott McAlister, Katherine A Barraclough, John Knight, Brendon L Neuen, Clare Arnott
Journal: The Lancet Planetary Health (2024)

The health-care sector is responsible for 5·2% of global emissions, however, little data exist regarding the environmental impact of disease management strategies. SGLT2 inhibitors are now widely used to reduce the risk of hospital admission and kidney failure in people with type 2 diabetes and chronic kidney disease. This study aimed to estimate the impact of SGLT2 inhibitors on greenhouse gas emissions using data from the CREDENCE trial.
Rome Foundation and international neurogastroenterology and motility societies’ consensus on idiopathic gastroparesis
Authors: Jolien Schol, I-Hsuan Huang, Florencia Carbone, Luis Maria Bustos Fernandez, Guillaume Gourcerol, Vincent Ho, Geoffrey Kohn, Brian E Lacy, Aurelio Lopez Colombo, Hiroto Miwa, Baha Moshiree, Linda Nguyen, Greg O’Grady, Kewin T H Siah, Vincenzo Stanghellini, Jan Tack
Journal: The Lancet. Gastroenterology & hepatology (2024)
Impact of radiotherapy dose, fractionation and immunotherapeutic partner in a mouse model of HR+ mammary carcinogenesis
Authors: Aitziber Buqué, Norma Bloy, Giulia Petroni, Carlos Jiménez-Cortegana, Ai Sato, Cristina Iribarren, Takahiro Yamazaki, Claudia Galassi, Michal Hensler, Bhavneet Bhinder, Andrea Guarracino, Brady Rippon, Manuel Beltran-Visiedo, Ruth Soler-Agesta, Tania Pannellini, Jitka Fucikova, Sandra Demaria, Xi Kathy Zhou, Olivier Elemento, Silvia C Formenti, Lorenzo Galluzzi
Journal: JNCI Journal of the National Cancer Institute (2024)

Abstract Background Hormone receptor (HR)+ breast cancer is poorly responsive to immune checkpoint inhibitors (ICIs). In some settings, radiation therapy (RT) has been shown to mediate immunostimulatory effects and promote ICI sensitivity. Methods We investigated whether hypofractionated RT may be successfully combined with ICIs in a mouse model of multifocal, metachronous HR+ mammary carcinogenesis. We hypothesized that focal RT targeting the first detectable (primary) tumor combined with ICIs may generate effective immunity, hence delaying the development of new lesions. Results Focal RT in various doses and fractionations limited primary tumor growth, with an optimum for a 20 Gy X 2 regimen (ablative in ∼90% of mice). The degree of primary disease control, however, did not necessarily correlate with overall survival (OS) extension, owing to changes in the development of new neoplastic lesions contributing to global tumor burden. Adding a PD-1 blocker to focal RT delivered in a 10 Gy X 3, 20 Gy X 2 or 8 Gy X 6 regimen failed to alter OS extension enabled by RT alone. Similar results were obtained with a CTLA4 blocker, an IL1B inhibitor, and a PD-1 blocker plus recombinant FLT3LG when combined with the 10 Gy X 3 regimen. Conclusions In this model of HR+ mammary carcinogenesis, RT to the primary tumor ameliorates OS (to an extent depending on dose and fractionation). Increasing local control by RT alone or RT plus immunotherapy beyond a hitherto undefined threshold, however, does not necessarily inhibit the development of subsequent non-irradiated neoplasms and hence does not necessarily provide extra OS benefits.
Saltational episodes of reticulate evolution in the <i>Drosophila saltans</i> species group
Authors: Carolina Prediger, Erina A Ferreira, Samara Videira Zorzato, Aurélie Hua-Van, Lisa Klasson, Wolfgang J Miller, Amir Yassin, Lilian Madi-Ravazzi
Journal: Molecular Biology and Evolution (2024)

Abstract Phylogenomics reveals reticulate evolution to be widespread across taxa, but whether reticulation is due to low statistical power or it is a true evolutionary pattern remains a field of study. Here, we investigate the phylogeny and quantify reticulation in the Drosophila saltans species group, a Neotropical clade of the subgenus Sophophora comprising 23 species whose relationships have long been problematic. Phylogenetic analyses revealed conflicting topologies between the X chromosome, autosomes and the mitochondria. We extended the ABBA-BABA test of asymmetry in phylogenetic discordance to cases where no “true” species tree could be inferred, and applied our new test (called 2A2B) to whole genome data and to individual loci. We used four strategies, two based on our new assemblies using either conserved genes or ≥50 kb-long syntenic blocks with conserved collinearity across Neotropical Sophophora, and two consisted of windows from pseudo-reference genomes aligned to either an ingroup or outgroup species. Evidence for reticulation varied among the strategies, being lowest in the synteny-based approach, where it did not exceed ∼7% of the blocks in the most conflicting species quartets. High incidences of reticulation were restricted to three nodes on the tree that coincided with major paleogeographical events in South America. Our results identify possible technical biases in quantifying reticulate evolution and indicate that episodic rapid radiations have played a major role in the evolution of a largely understudied Neotropical clade.
Novel IgG-IgM Autoantibody Panel Enhances Detection of Early-stage Lung Adenocarcinoma from Benign Nodules
Authors: Rongrong Luo, Xiying Li, Ruyun Gao, Mengwei Yang, Juan Cai, Liyuan Dai, Nin Lou, Guangyu Fan, Haohua Zhu, Shasha Wang, Zhishang Zhang, Le Tang, Jiarui Yao, Di Wu, Yuankai Shi, Xiaohong Han
Journal: Genomics Proteomics & Bioinformatics (2024)

Autoantibodies hold promise for diagnosing lung cancer. However, their effectiveness in early-stage detection needs improvement. We investigated novel IgG and IgM autoantibodies for detection of early-stage lung adenocarcinoma (Early-LUAD) across three independent cohorts of 1246 individuals. A multi-step approach, including Human proteome microarray (HuProtTM) discovery, focused array verification, and ELISA validation, was conducted on 634 individuals with Early-LUAD (stage 0-I), 280 with benign lung disease (BLD), and 332 normal healthy controls (NHC). HuProtTM profiling discovered 417 IgG/IgM candidates, and focused array verified 32 autoantibodies with distinct distributions in Early-LUAD and BLD/NHC. A novel panel of 10 autoantibodies (ELAVL4-IgM, GDA-IgM, GIMAP4-IgM, GIMAP4-IgG, MGMT-IgM, UCHL1-IgM, DCTPP1-IgM, KCMF1-IgM, UCHL1-IgG, and WWP2-IgM) demonstrated a sensitivity of 70.5% and specificities of 77.0% or 80.0% in detecting Early-LUAD from BLD or NHC in ELISA validation. Positive predictive value for distinguishing Early-LUAD from BLD with nodules ≤ 8 mm, 9 ≤ IMD ≤ 20 mm, and > 20 mm significantly increased from 47.27%, 52.00% and 62.90% [low-dose computed tomography (LDCT) alone] to 79.17%, 71.13% and 87.88% (10-autoantibody panel with LDCT), respectively. The combined risk score (CRS), based on 10-autoantibody panel, sex, and imaging maximum diameter, effectively stratified risk for Early-LUAD. Individuals with scores 10-25 and > 25 indicated a higher risk of Early-LUAD compared to the reference (scores < 10), with adjusted odds ratios of 5.28 (95% CI:3.18-8.76) and 9.05 (95% CI:5.40-15.15), respectively. This novel panel of IgG and IgM autoantibodies offers a complementary approach to LDCT in distinguishing Early-LUAD from benign nodules.
‘Behind the scenes’ of a clinic appointment: Insights from the patient experience of eczema
Authors: Ria Patel
Journal: British Journal of Dermatology (2024)

This article reflects on my experience as both a clinical medical student and a dermatology patient, providing insights into the lived experience of eczema beyond the clinic setting. It offers a patient’s perspective on how clinicians can empower patients by acknowledging the daily impact of their condition.
Integrating artificial intelligence into skin cancer pathways; the opportunities and obstacles
Authors: Buket Beresford-Wylie, Samuel Ashcroft, Bindi Gaglani, Alice Green, Robert W Smillie, Katie Tucker, Ameet Bakhai, Ben Esdaile, Ioulios Palamaras
Journal: British Journal of Dermatology (2024)

Artificial intelligence (AI) is a possible paradigm shift in our ability to provide dermatology services. Our article endeavours to outline the opportunities and obstacles faced by our specialty with integrating AI into our departments.
Discharge Medication After Natriuresis-Guided Dosing of Diuretic Therapy in Patients Hospitalized for Acute Heart Failure
Authors: Adriaan A Voors, Kevin Damman, Iris E Beldhuis, Peter van der Meer, Jan A Krikken, Jenifer E Coster, Wybe Nieuwland, Dirk J van Veldhuisen, Jozine M Ter Maaten
Journal: JACC Heart Failure (2024)
The Biology and Clinical Implications of PCSK7
Authors: Vatsal Sachan, Delia Susan-Resiga, Kalista Lam, Nabil G Seidah
Journal: Endocrine Reviews (2024)

Discovered in 1996, PCSK7 is the seventh of the nine-membered proprotein convertase subtilisin-kexin (PCSK) family. This article reviews the various aspects of the multifaceted biology of PCSK7 and what makes it an exciting new target for metabolic dysfunction-associated steatotic liver disease (MASLD) affecting ∼30% of the population globally, dyslipidemia, cardiovascular disease (CVD), and likely cancer/metastasis. We will systematically review and discuss all the available epidemiological data, structural, cell biology, and in vivo evidence that eventually led to the discovery of PCSK7 as a novel post-translational regulator of apolipoprotein B. Interestingly, PCSK7 is the only convertase, other than PCSK9, that exhibits non-canonical/non-enzymatic functions, which will be amply described in this review. The data so far suggested that PCSK7 is a potential safe target in MASLD treatment. This was based on human epidemiological data, as well as mouse Pcsk7 knockout and mRNA translation inhibition using hepatocyte-targeted antisense oligonucleotides following a diet-induced MASLD. Additionally, of all the 9 convertases only the gene deletion of Pcsk7 and/or Pcsk9 in mice leads to healthy and fertile animals with no apparent deleterious consequences, suggesting that their pharmacological targeting is likely safe. Accordingly, the synergistic effects of inhibiting both PCSK7 and PCSK9 in a clinical setting may represent a novel therapy for various diseases. We believe that the current surge in oligonucleotide therapy, with many FDA-approved oligonucleotide-based drugs now available in the clinics, and the urgent need for novel MASLD therapeutics present an opportune moment for this timely review article.