tbuckley/cabot-search huggingface dataset:
Multiorgan Involvement of Systemic Lupus Erythematosus in a Patient With Negative Serology: A Lupus Criteria Dilemma
Authors: S. Wajid, L. Grigoryan, A. Pal, M. Faiz, L. Masood, M.S. Wasim, R. Peredo-Wende
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Severe Hyponatremia in Obstructive Uropathy With Post Obstructive Diuresis
Authors: N. Frattaroli, D. Morales, N. Gonzalez, L. Jorde, J. Avigan, E. Bailey, J. Penn, E. Brezel, C. Kalish, G. Nangia, M. Sunseri
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Navigating the Gas Traps: Conservative Triumph in Gastric Pneumatosis and Pneumatosis Portalis
Authors: I. Andriushchenko, C.J. Eneh, M.H. Zaman, S. Ogbonda, F. Debellotte, M. Chandio, G. Derevenskikh, N. KC, K. Kozii, E. Ukenenye
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Clinical Challenge: Managing Euglycemic Diabetic Ketoacidosis in a Post-Whipple Procedure Patient on SGLT-2 Inhibitors and GLP-1 Agonist
Authors: H. Butt, D. Rajagopalan, S. Ahsan, A. Ahmad, S. Wettimuny, A. De La Torre, R.A. Shah
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Sex Based Disparities in Mechanical Ventilation for ARDS Patients: A Focus on Lung Cancer Comorbidity
Authors: J.A. Galindo Castaneda, A.B.M.N. Alam, A. Grange, J.A. Biguerias Osuna, E. Figueroa, A. Harb
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
A Validated 4-gene Signature to Exclude Bacterial Etiology of Lower Respiratory Tract Infection
Authors: T.J. Mariani, D. Peterson, S. Bhattacharya, A. Baran, C.-Y. Chu, M. Peasley, J. Ashton, D. Croft, A. Branche, E. Walsh, A. Falsey
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
The Negative Predictive Value for Malignancy of Non-diagnostic Robotic Bronchoscopy Results in the Setting of Tool-in-Lesion Intraprocedural Cone Beam Imaging
Authors: V.J. Kiselevskaya, M. Andronov, K. Lobo, B. Balan, D. Dibardino
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
A Systematic Review and Meta-analysis to Assess the Safety and Efficacy of Nebulised Colistin as an Adjunct for the Treatment of Ventilator Associated Pneumonia (VAP)
Authors: I. Pugazhendi, A. Agrawal, T. Imtiaz, J. Ramharack, N. Mahmood, V. Nookala, P. Cheriyath
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Development and Nested Cross-Validation of Explainable Machine-Learning Models for Predicting the Risk of Propofol-Associated Hypertriglyceridemia in Critically-Ill, Mechanically-Ventilated Patients
Authors: J. Deng, K. Heybati, G. Xie, K. Poudel, Y. Hemang
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Glycocalyx Shedding Product Sydecan-1 as a Predictor of Increased Lung Vascular Permeability and Outcome in Patients With Neurogenic Pulmonary Edema After Subarachnoid Hemorrhage
Authors: T. Mutoh, R. Tochinai, J. Moroi, M. Kuwahara, T. Ishikawa
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
MicroRNA-Based Therapy as a Potential Treatment for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS)
Authors: J.L. Pavelick, C.M. Vaswani, G.W. Tan, S.S. Batah, A.M. Ektesabi, J.N. Tsoporis, C.C. Dos Santos, J. Pavelick
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Relationship Between NIV Telemonitoring Data and Patient-reported Outcomes (S<sup>3</sup>NIV) in the First Six Months of Treatment: The INOVAL-1 Study
Authors: S. Pontier, Z. Owadally, M. Guillemot, R. Barthes, D. Adler, J.C. Borel, M. Lebret, M. Rahim, J.B. Texereau
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Utilizing Artificial Intelligence for Enhanced Interpretation of Endotracheal Tube Position in Chest Radiographs
Authors: M.-J. Tsai, C.-H. Cheng, L.-L. Wang, D.-C. Shih, W.-A. Chang, C.-J. Lee, C.-C. Sheu, Y.-C. Liou
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
The High Prevalence of Rare Pulmonary Diseases Among Patients With Severe Asthma
Authors: A.T. Samad, P. Avillach, S.W. Kong, M.-S. Ong, A. Geva, E. Mendonca, R.L. Davis, S. Chun, J.M. Gaffin, A.M.H. Casey, K.D. Mandl, B.A. Raby
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Safety and Efficacy of Bronchus-Blocked Ultrasound-Guided Percutaneous Transthoracic Needle Biopsy (BUS-PTNB) for Critically Ill Patients Under Invasive Mechanical Ventilation: A Prospective, Single-Arm Trial
Authors: H. Yu, Y. Liu, X. Lin, W. Wang, J. Fan, Y. Wang
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Use of Systemic Corticosteroids and Antibiotics in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation Receiving Dupilumab
Authors: M. Bafadhel, A. Anzueto, J. Bourbeau, A. Papi, S.P. Bhatt, S. Korn, I. Satia, F.J. Martinez, G. Deslee, C. Xia, J. Heble, M. Soliman
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
A Scoping Review of Experimental Acute Lung Injury in Preclinical Settings: A Call to Improve Methodologies for Enhanced Translatability
Authors: G. Fior, A. Natani, K. Liu, A. Milani, F. Baccoli, H. Nonaka, K. Hoshino, J. Graham, C. McGrath, C. Zhang, J. Suen, J.F. Fraser, G. Li Bassi
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Pulmonary Gangrene Among COVID-19 Patients: A National Analysis of a Rare, Yet Dangerous Complication
Authors: K.B.S. Dhaliwal, K. Mahajan, A. Grewal, P.P. Boyne, R. Verma, R. Kamleshun, S. Hemamalini, K. Kaur
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Unveiling the Role of Pulmonary Inflammatory Biofluids in Propagating Early Acute Lung Injury
Authors: G. Fior, A. Milani, K. Liu, O. Nchafatso, H. Nonaka, J. Bösch, J. Smalcova, K. Hoshino, I. Schinichi, S. Portatadino, G. Abbate, R. Panduru, S. Parker, K. Hyslop, M. Bouquet, M. Passmore, N. White, J. Suen, J.F. Fraser, G. Li Bassi
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Population-based Frequency and Functional Characterization of a Pathogenic ABCA3 Intronic Variant Associated With Lethal Neonatal RDS
Authors: J.A. Wambach, D.J. Wegner, S.A. Hamilton, P. Yang, M. Leff, C. Min, G.A. Giraldo Ospina, A. Uribe, F.S. Cole
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Speaking Common Longitudinal ICU Data Format (CLIF): A Large Language Model for Critical Care Phenotyping
Authors: V. Chaudhari, K. Chhikara, B. Beaulieu-Jones, M. Burkhart, C. Gao, N.E. Ingraham, W.F. Parker, J.C. Rojas
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Dynamic Changes in Renal Angina Index for Predicting Acute Kidney Injury in Septic Shock
Authors: K. Kumar, S. Gautham, S. Rao, K. Karabulut Kapici, P. Lakra, S. Venkat Ramanan, C. Tanba, S.P.S. Cherukuri, K.R. Nunna
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Brains vs Bytes: Who Predicts Mortality Better in Patients With Acute Kidney Injury on Continuous Renal Replacement Therapy - Clinicians or Artificial Intelligence?
Authors: R.J. Gonzalez, M. Sadrolashrafi, M.C. Morales Alvarez, S. Cabral, H. Ferrera, S. Rokaw, M. Samuel, L. Celi, P. Czarnecki, E. Stevenson
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Preload-dependent Left Ventricular Collapse During Hemodialysis in a Patient With Cardiorenal Syndrome and Diastolic Dysfunction
Authors: F.A. Rauf, G. Swaminathan, M. Haseeb Ul Rasool, D. Miller, N. Al-Howthi, S. Patrizi, J. Muratori, T. Trandafirescu
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Acute Exacerbation of Interstitial Lung Disease Is Associated With Significantly Increased Mortality Compared to Acute Respiratory Distress Syndrome Despite Lower Systemic Inflammation
Authors: J. Deberry, G. Kitsios, W. Bain, L.K. Sharma, C.S. Dela Cruz, M.I. Seedahmed, Y. Zhang, D. Kass, E. Valenzi, B.J. Mcverry, F.A. Shah
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
A Novel Platinum(IV) Prodrug, Gramine-Pt(IV) Enhances Chemoimmunotherapy by activating cGAS-STING and modulating TGF-β-MHC-I axis
Authors: Bowen Ding, Xiaomeng Liu, Zhe Li, Xinru Xie, Jiaqi Li, Jiaqian Wang, Shouyi Li, Pengyu Wang, Yongjie Xie, Xiaoqing Ma, Hongwei Wang, Chengzhi Xie, Xin Qiao, Yumin Wang, Jingyuan Xu, Yukuan Feng, Jihui Hao
Journal: Drug Resistance Updates (2025)
COPD-HELP: A Randomised Controlled Trial of Mepolizumab Initiated Following Admission to Hospital for a Severe Exacerbation of Eosinophilic COPD
Authors: C. Flynn, H.J.C. McAuley, O. Elneima, H.W.W. Aung, W. Ibrahim, T.J.C. Ward, M. Bourne, T. Thornton, V. Mistry, G. Waheed, H.R. Gilbert, A.K.A. Wright, R.A. Evans, M.C. Steiner, C.L. Brookes, C.E. Brightling, N.J. Greening
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Infection Specific Versus General Early Warning Scores for Predicting Sepsis on a Medical-Surgical Ward: A Multicenter Analysis
Authors: D. Edelson, M.M. Churpek, K. Carey, Z. Lin, C. Huang, J.M. Siner, J. Johnson, H. Krumholz, D. Rhodes
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
The Association of Type 2 Diabetes Mellitus (T2DM) and Hypertension (HTN) With Mortality Among Patients With Acute Respiratory Distress Syndrome (ARDS): A Systematic Review and Meta-analysis
Authors: A. Saha, M. Kennedy, G. Stone, Y. Zu, A. Sisk, M. Brown, A. Corder, J. Shaffer, R. Kashyap, N. Qadir, J.L. Denson
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
A Peer-Led Rapid Response Curriculum Improves Confidence and Clinical Decision Making Among Internal Medicine Residents
Authors: D. Potarazu, K. Santerian, K. Motley, R. Strock, J. Hall, E. Oskar, S. Tittaferrante, D. Shah Pandya, A. Ajmeri
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Boosting the Confidence of the Code Leaders of Tomorrow - A Quality Improvement Project
Authors: V. Turcan, A. Hassan, N. Khalid, A. Ruppel, S. Kananeh, A. Vazquez Gonzalez, B. Ghafoor, A. Abdelrehim, V. Muyolema Arce, E. Vypritskaya
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
A Case of Acute Onset Minimal Change Disease in a 92 Year Old Male Mimicking Heart Failure
Authors: L. Philip, C. Talone, N. Patel, S.H. Gandhamaneni, R. Al-Ahmad, S. Khawam, L. Morrison, S. Hassan, P. Patel, G. Hassinger
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Tezepelumab: Real-life Experience in Specialized Severe Asthma Units in Northern Spain
Authors: R. García Hernáez, T. Hermida Valverde, M.V. Garcia-Gallardo Sanz, J.L. Garcia Rivero, A. Pallares Sanmartin, L. Carazo Fernández, S. Dorronsoro Quintana, A.I. Enriquez Rodriguez, I. De Los Santos, U. Calvo Alvarez, I. Carrascosa Anguiano, A. Lama López, A. Mardones Charroalde, L. Perez-De-Llano
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Mechanistic Insights Into Human Immunodeficiency Virus (HIV)-Associated Pulmonary Hypertension: Influence of Time and HIV Nef Sequence Variations in Nitric Oxide Synthesis and Inflammatory Cytokine Production in Pulmonary Vascular Cells
Authors: A. Garcia, E. Heath, M. Nguyen, P. Campbell, M. Rodriguez, N. Lujea, S. Almodovar
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
The Dimethyl-Methylene Blue Assay Rapidly Detects Circulating Sulfated Glycosaminoglycans in Children With Acute Respiratory Failure
Authors: C.J. Sallee, B. Lopez, A.B. Maddux, J.A. Hippensteel, K. Oshima, P.M. Mourani, A. Schwingshackl, E.P. Schmidt, A. Sapru
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
International CCHS Secure Health-hub Advancing Research Efforts (SHARE) Registry: Analysis of Patient-Reported Symptoms by PHOX2B Genotype in Congenital Central Hypoventilation Syndrome (CCHS)
Authors: D. Vandemore, C. Rand, E. Lonergan, D.E. Weese-Mayer
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Long-Term Protection by Mesenchymal Stromal Cell-Derived Extracellular Vesicles in a Double-Hit Model of Neonatal Hyperoxia and House Dust Mite-Allergen Challenges
Authors: V.T. Ha, S. Tung, J.-K. Kim, X. Liu, J. Cortinas, Y. Hao, E. Obeng, A. Mitsialis, S. Kourembanas
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Proactive Patient Management: Evaluating the Role of Clinical Deterioration Index (CDI) in Deterioration Detection and Reduction of Rapid Response Team (RRT) Utilization
Authors: A. Abu Shanab, S.R. Gaddameedi, M. Alrjoob, D. Aquino, A. Khalid, R.S. Macasaet, F. Payal, P. Fish
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Assessing Reliability, Reproducibility, and Adherence of Home Spirometry in Patients With Idiopathic Pulmonary Fibrosis: A Korean Multicenter Prospective Study
Authors: H.-Y. Yoon, S.-W. Park, J. Park, S.M. Choi, W.-I. Choi, J.H. Park, J. Lee, Y.S. Jo, H.K. Kang, J. Kang, S.Y. Kim, A. Woo, H. Yoo, Y.H. Kim, J.S. Park, E.J. Lee, J.H. Oh, J.W. Song
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Stability of Blood Eosinophil Counts in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation in the BOREAS and NOTUS Trials
Authors: M. Bafadhel, N.N. Hansel, W.L.H. Janssens, S. Muro, D.J. Maselli, J.H. Yun, J.A. Wedzicha, S.A. Christenson, P. Saha-Chaudhuri, D.M. Cunoosamy, M. Soliman, J. Heble
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Association Between Baseline Fractional Exhaled Nitric Oxide and Mucus Response in Patients With Uncontrolled Moderate-To-Severe Asthma Treated With Dupilumab in the Vestige Study
Authors: A. Bourdin, L.A. Pérez de Llano, S.P. Bhatt, E.M. Dunican, N.L. Lugogo, M. Castro, A. Papi, A.P. Comellas, A. Altincatal, X. Soler, H. Awad
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Outcomes of Mechanical Ventilation in Patients With Lung Cancer and ARDS: A Nationwide Analysis
Authors: J.A. Galindo Castaneda, A.B.M.N. Alam, Y. Petryshyn, A. Abdelkhalek, L. Nagarajan, J.A. Biguerias Osuna, E. Figueroa
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Validation of a Dried Blood Spot-based Assay for Detection of RSPH4A Founder Mutation in Primary Ciliary Dyskinesia: A Population-based Screening Tool for Puerto Rico
Authors: E.L. Acevedo Soto, K. Guerra Torres, A. Rosado-Ayala, J. Martínez-Cruzado, M.J. Ramos-Benitez, W. De Jesus-Rojas
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Adequacy for Next Generation Sequencing in Endobronchial Ultrasound Guided Transbronchial Needle Aspiration (EBUS-BNA) Specimens vs. Liquid Biopsies in Patients With Non-small Cell Lung Cancer (NSCLC)
Authors: T. Ferguson, N.J. Pastis, C.R. Gilbert, J. Thiboutot, A. Fox, N.T. Tanner, L.B. Yarmus, R. Ward, C. Ghattas, J.K. Pannu, A.E. Revelo, G.A. Silvestri
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Association Between Lidocaine Infusion and Acute Renal Failure Requiring Dialysis: A Retrospective Propensity Score-matched Study
Authors: J. Alvarado, C.A. Pérez-Velásquez, G.E. Fonseca-Medina, G.J. Gonzales-Pereira, A.F. Mora-Salamanca
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Predictors Factors of Mortality Related to Prone Positioning Among Individuals With Moderate to Severe ARDS Due to COVID-19: A Multicenter Retrospective Study
Authors: M. Cunha, J. Schardong, N.C. Righi, A.C. Lunardi, R.F. Xavier, A.M.V.D. Silva, A.C. Starke, F.M. Mortimer, D.L. Matte, R.D.M. Plentz, J.C. Ferreira, C.R.F.D. Carvalho
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Novel Compounds Targeting the Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-2 (MK2) Binding Site in P38alpha MAPK Exhibit Distinct Biological Effect Profiles
Authors: M. Tulapurkar, A. Mackerell, F. Steven, R. Lal, P. Shapiro, J.D. Hasday
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Mepolizumab in patients with COPD: Results from the MATINEE Phase III Randomized Controlled Trial
Authors: N. Roche, I.D. Pavord, F.C. Sciurba, J. Bourbeau, J. Min, S. Kolterer, B. Mayer, S. Gould, F.J. Martinez
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Novel Compounds Targeting the Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-2 (MK2) Binding Site in P38alpha MAPK Exert Distinct Anti-inflammatory Effects on Gene Expression in TNFalpha-stimulated Endothelial Cells
Authors: M. Tulapurkar, R. Lal, A. MacKerell, S. Fletcher, P. Shapiro
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Impact of Biologic Initiation on New-onset of Corticosteroid-related Adverse Effects in Patients With Severe Asthma
Authors: D.B. Price, B. Emmanuel, G. Scelo, A. Altraja, B. Cochrane, W. Chen, M.S. Koh, I. Solarte Rodriguez, M.-J. Tsai, C.S. Ulrik, C. Bergeron, G.C. Christoff, A. Gogali, S. Hansen, M. Hew, R. Katial, L. Perez-De-Llano, F. Puggioni, A.A. Bulkhi, A. Côté, C. Emmas, L.G. Heaney, L.J. Jimenez Maldonado, P.D. Mitchell, A.I. Papaioannou, F. Schleich, C.-C. Sheu, J. Maspero, P.G. Gibson, C.A. Torres-Duque, C.M. Porsbjerg, A. Bourdin, G.W. Canonica, E. Heffler, T. Iwanaga, D. Larenas-Linnemann, P. Kuna, R.O. Al-Lehebi, C.K. Rhee, B.G. Cosio, D.-W. Perng, B. Mahboub, J. Busby, D.J. Jackson, P.H. Patel, P.E. Pfeffer, K. Fletton, R.B. Murray, J. Townend, T.N. Tran
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Lung Ultrasound-based Artificial Intelligence Prediction of Congestive Heart Failure Readmission
Authors: L. Hutchins, J. Duplantis, G. Gare, J. Armouti, M. Shivaram, T. Deiss, T.H. Fox, A. Krishnan, R. Rodriguez, J. Galeotti, B.P. Deboisblanc
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Mood and Psychotic Disorders as Prognostic Factors for Sepsis and Septic Shock Mortality: A Meta-Analysis
Authors: A. Gupta, T. Tejpal, C. Seo, N. Fabiano, Y. Qiu, S. Wong, J. Talia, M. Solmi, J. Fiedorowicz
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Neutrophil-to-Lymphocyte Ratio and Post-Tuberculosis Pulmonary Function: A Potential Marker for Reduced Function
Authors: J. Dinh, M. Paradkar, S. Gaikwad, N. Suryavanshi, N. Gupte, V. Kulkarni, N. Pradhan, A.C. Law, L.E. Hanna, V. Mave, C. Padmapriyadarsini, A. Gupta, A. Gupte
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Intermittent Hypoxia Induces Epigenetic Changes and P16-mediated Senescence in Left Cardiac Ventricle and Aorta Which Are Associated With Vascular Dysfunction
Authors: R.G. Cortese, K. Cataldo, M. Badran, Z. Qiao, A. Khalyfa, D. Gozal
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Efficacy of Tezepelumab in Adults With Severe, Uncontrolled Asthma Across Multiple Exacerbation Trigger Types: The Phase 3 Direction Study
Authors: C.S. Ambrose, X. Yang, L. Wang, K. Huang, W. Tang, E.J. Berame, H.-S. Park, G. Hunter, W. Jiang, C.C. Wu, C.W. Min, K. Domek-Łopacinska, H. Lal, N.A. Molfino, S.S. Ponnarambil, N. Zhong
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Differential Correlation Network Analysis Illustrates Novel Biomarker Interactions Underlying Hyperinflammation in Pediatric ARDS
Authors: M.S. Taylor, M.S. Zinter, D. Markovic, M.J. Lim, C.J. Sallee, M. Butte, A. Schwingshackl, M. Pellegrini, A. Sapru
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
HDAC inhibitors: Cardiotoxicity and paradoxical cardioprotective effect in ischemia-reperfusion myocardiocyte injury
Authors: Kenneth K W To, Seda Tolu, Longling Wang, Hang Zhang, William C Cho, Susan E Bates
Journal: Seminars in Cancer Biology (2025)

Histone deacetylase inhibitors (HDACIs) are epigenetic drugs that regulate the acetylation status of histones and non-histone proteins, thereby leading to chromatin remodeling and transcriptional regulation of key apoptotic and cell cycle regulatory genes. There are currently five HDACIs clinically approved by the major regulatory authorities for treating hematological cancers, primarily as monotherapy. While HDACIs have been particularly effective in T-cell lymphomas, their clinical efficacies have not yet extended to solid tumors. The development of HDACIs continues, including for the treatment of a non-malignant conditions, with givinostat recently approved by the US FDA. However, the early development of HDACIs was limited by concerns about cardiotoxicity including QT interval prolongation. Yet, paradoxically, the latest research suggests some cardioprotective effect of HDACIs in ischemic heart disease or heart failure. This review presents the latest update about the cardiotoxicity of the clinically approved HDACIs. The mechanisms leading to HDACI-induced cardiotoxic adverse events and clinical strategies for their management are discussed. We will also deliberate the potential repurposing use of HDACIs and their HDAC isoform selectivity for treating ischemia-reperfusion cardiac muscle injury, cardiac hypertrophy, and fibrosis.
Population-specific Risk of Intensive Care Patient Pharmacogenomics-related Inaccurate Drug Dosing
Authors: M. Rostami, J. Rodriguez-Flores, A. Al Shakaka, H. Khan, M. Vakayil, A. Ait Hssain, J.G. Mezey, R.J. Kaner, A. Robay, R.G. Crystal
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Deep Learning Identifies Patients at Risk of Rapid Radiologic Progression in Pulmonary Fibrosis
Authors: S.M. Humphries, D. Baraghoshi, D. Thieke, E.R. Fernández Pérez, T.J. Huie, R.C. Keith, M. Koslow, M.P. Mohning, J. Pryor, J. Solomon, J.J. Swigris, Z.X. Yunt, K.K. Brown, D.A. Lynch
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Is Watchful Waiting a Viable Strategy in Mycobacterium Avium Complex Pulmonary Disease? Insights From a Propensity-matched Cohort Study
Authors: A. Hwang, M.C. Kim, H.T. Hwang, S.M. Yoon, D.-H. Joo, Y.J. Lee, M.J. Song, B.S. Kwon, Y.W. Kim, S.Y. Lim, Y.-J. Lee, J.S. Park, Y.-J. Cho, J.H. Lee, C.-T. Lee, H.-J. Kim
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Efficacy of Tezepelumab on Upper and Lower Airway Outcomes in Adults With Severe, Uncontrolled Chronic Rhinosinusitis With Nasal Polyps in Patients With and Without Comorbid Asthma: Results From the Phase 3 Waypoint Study
Authors: M. Desrosiers, J.K. Han, B.J. Lipworth, C. Hopkins, S.E. Lee, J. Mullol, O. Pfaar, T.M. Laidlaw, A.T. Peters, A.A. White, C.S. Ambrose, T. Li, C. Chen, G. Almqvist, M.K. Margolis, J. McLaren, S. Jagadeesh, V.S. Mankad, L. Bahadori, S.S. Ponnarambil
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Development of a Training Framework for Radiographic Assessment of Lung Edema (RALE) Scoring and Assessment of Inter-rater Reliability in Acute Respiratory Failure
Authors: P. Jain, H. Qurashi, N. Singh, K. Inman, A.N. Rizzo, V.L. Gipson, J. Sinopoli, T.M. Mirza, R. Ali, N. Naghshtabrizi, H. Bobrysheva, N. Venkatesan, K. Golubykh, N. Prendergast, K. Samanthapudi, C. Schaefer, R. Joyce, K. Mitchel, E. Hughes
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Provider Bias in Decision Making About Treatment of Early-stage Lung Cancer With Stereotactic Body Radiation Therapy or Sub-lobar Resection
Authors: J. Mudd, H. Zafar, G. Mhango, C.G. Slatore, R.M. Flores, S. Swanson, K. Rosenzweig, J.A. Kern, J.P. Wisnivesky
Journal: American Journal of Respiratory and Critical Care Medicine (2025)
Characteristics and Clinical Course of Hospitalized Patients Receiving Benzodiazepines, Phenobarbital, or Both Treatments for Alcohol Withdrawal Syndrome in a University Health System: A Retrospective Case Series and Qualitative Study
Authors: C. Tian, K.A. Bradley, N.J. Johnson, K.A. Hallgren, T.E. Matson, A.H. Weeks, J.W. Schattenkerk, H. Nadeem, K.M. Gressman, C.W. Fling, R. Desta, A.J. Choi, T.L. Steel
Journal: American Journal of Respiratory and Critical Care Medicine (2025)