tbuckley/cabot-search huggingface dataset:
Abstract 9589: Conduction Abnormalities in Pediatric Patients with Restrictive Cardiomyopathy
Authors: Mark A Walsh, John L Jefferies, Jeffrey A Towbin, Richard J Czosek
Journal: Circulation (2011)

Introduction: Pediatric restrictive cardiomyopathy (RCM) carries a poor prognosis secondary to a high risk of sudden cardiac death. Sudden death in pediatric patients has previously been attributed to ventricular tachyarrhythmias. There are many reasons why patients with RCM might develop conduction system disease and it is conceivable that in the acute setting, this might be a triggering event for sudden death. Methods: A single center, retrospective chort of pediatric patients with RCM, diagnosed between April 1994 and April 2011 was analyzed for conduction system abnormalities and potential triggering events for sudden death. Patient demographic, cardiac and electrocardiographic characteristics were reviewed. Incidence of sudden cardiac events was determined (defined as death or an episode of acute hemodynamic compromise felt to be secondary to a cardiac arrhythmia). Non-parametric statistical methods were used to determine associations between clinical characteristics and sudden cardiac events. Results: Fifteen patients (1 - 17 years) were reviewed; there were 5 sudden cardiac events including 4 deaths. Two of the deaths were precipitated by the abrupt onset of complete heart block. Another patient with syncope had intermittent heart block and survived as a result of the defibrillator pacing features. Sudden cardiac events were statistically associated with an older age ( p &lt;0.01 ). On initial presentation, the median PR interval (222 vs. 140 msec; p &lt; 0.01 ) and the median QRS duration (111 vs. 73.5; p = 0.01 ) was significantly longer in those having an acute cardiac event. No other functional or echocardiographic variables were associated with a sudden cardiac event. Conclusion: Pediatric patients with RCM are at risk for acute high grade heart block and bradycardic events may represent a significant portion of all arrhythmic events. Since PR interval prolongation and wider QRS complex were associated with acute cardiac events, these findings suggest increased monitoring for bradyarrhythmic episodes with consideration for prophylactic pacemaker implantation in certain patients. Particular care should be taken in patients with RCM and evidence of conduction system disease.
PROX1 IS A PREDICTOR OF SURVIVAL FOR ASTROCYTIC GLIOMAS BUT NOT FOR OLIGODENDROGLIOMAS GRADE II
Authors: T. Elsir, M. Qu, Shala Berntsson, A. Orrego, T. Olofsson, M. Lindström, M. Nister, Dan Ribom, Anja Smits
Journal: Neuro-Oncology (2010)

PROX1 IS A PREDICTOR OF SURVIVAL FOR ASTROCYTIC GLIOMAS BUT NOT FOR OLIGODENDROGLIOMAS GRADE II
The Circulatory Disturbances of the Extremities. Including Gangrene, Vasomotor and Trophic Disorders.
Authors: Leo Buerger
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immune signatures hold prognostic import across solids tumors
Authors: S. D. Hsu, C. K. Anders, C. R. Acharya, Y. Zhang, Y. Wang, J. A. Foekens, K. L. Blackwell, C. G. Drake, M. A. Morse, P. G. Febbo
Journal: Journal of Clinical Oncology (2007)

21041 Background: The host immune response can impact cancer growth, prognosis, and response to therapy. In colorectal cancer, the presence of cells involved with T-cell mediated adaptive immunity better predicts of survival than the current staging method. Immune signatures based on host response to cancer have the potential to predict prognosis and facilitate target specific therapy. Methods: We used the gene expression data associated with immune host response to colorectal cancer (Galon et al., Science 2006) to perform hierarchical clustering of solid tumors for which the clinical annotation were available. Specifically, prostate (n=79), breast (n=132), lung (n=37), and lymphoma (n=127) samples were clustered based upon expression of genes associated with host immune responses (Th1 mediated adaptive immunity (Th1), inflammation, and immune suppression (IS)). Kaplan-Meier survival analysis was then used to determine if major sample clusters had significantly different disease free survival. Results: Clusters with differential prognosis (disease free survival) were consistently seen across all tumors. Among adenocarcinomas, and similar to previously published colorectal data, the Th1 genes were consistently associated with better prognosis. Specifically, in breast cancer patients, increased expression of the Th1 genes was protective, but only in patients under 45 years of age (HR=0.42; p=0.05). In prostate cancer, patients with increased expression of the Th1 genes and inflammation genes had better prognosis when compared to those without the Th1 genes (HR=0.36; p=0.03) or inflammation genes (HR=0.37; p=0.03). Lung cancer patients expressing the Th1 genes and IS genes appear to have improved survival when compared to those without the IS genes (HR=0.33; p=0.08). In contrast, Th1 genes were associated with poorer prognosis in lymphoma patients. Patients with decreased Th1 genes and increased expression of inflammation genes had better prognosis than those expressing the Th1 genes (HR=0.43; p=0.013) or IS genes (HR= 0.35; p=0.002) only. Conclusions: Signatures of the host immune response to solid tumors hold prognostic significance. Future work will determine if immune signatures can be predictive of response to therapy and help guide management. No significant financial relationships to disclose.
Medical Management of Gastric Ulcer
Authors: G. G. Richards
Journal: Annals of Internal Medicine (1929)

Article1 February 1929Medical Management of Gastric UlcerG. G. RICHARDSG. G. RICHARDSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-8-771 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe most important single factor in the treatment of a gastric ulcer is an accurate diagnosis. To subject a patient to a long period of careful dieting and control of his acid for an ulcer that does not exist is wasted effort and certainly not appreciated by the patient. To operate on him and perform a needless gastroenterostomy is not to be excused. To attempt an ulcer cure medically for a malignancy of the stomach, whose only hope lies in surgery, will remain a face in the darkness of one's own conscience even after his mistake is hidden in the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Salt Lake City, Utah*From the Salt Lake Clinic, Salt Lake City, Utah.†Read before the Southwest Idaho Medical Society on May 9, 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1929Volume 2, Issue 8Page: 771-795KeywordsGastric ulcersGastroenterology and hepatologySaltsStomachSurgeryUlcers ePublished: 1 December 2008 Issue Published: 1 February 1929 PDF downloadLoading ...
Les groupes sanguins, schémas et applications pratiques: La transfusion sanguine, technique et indications.
Authors: Paul Michon
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Consulting Surgeon in the Near East.
Authors: A. H. Tubby
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atypical E2F Dependent Dysregulation Of Cell Cycling By Microrna-142 Regulates T-Cell Responses and Experimental Graft-Versus-Host Disease
Authors: Yaping Sun, Kay Oravecz-Wilson, Thomas Saunders, Ying Wang, Tomomi Toubai, Nathan Mathewson, Chen Liu, Guoqing Hou, Emily Cummings, Charles Ross, Pavan Reddy
Journal: Blood (2013)
Recapitulation of in vivo-like paracrine signals of human mesenchymal stem cells for functional neuronal differentiation of human neural stem cells in a 3D microfluidic system
Authors: Kisuk Yang, Hyun-Ji Park, Sewoon Han, Joan Lee, Eunkyung Ko, Jin Kim, Jong Seung Lee, Ji Hea Yu, Ki Yeong Song, Eunji Cheong, Sung-Rae Cho, Seok Chung, Seung-Woo Cho
Journal: Biomaterials (2015)
STATISTICS, SCIENCE, AND SENSE
Authors: Sidney Shindell
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sustainability of medical imaging: Proposed licensing system and consent procedure are impractical
Authors: Bob Bury
Journal: BMJ (2004)

Editor—It is difficult to argue with Picano's premise that it would be a good thing if the doctors who referred patients for examinations using ionising radiation had a clearer idea of the risks involved.1 However, Hardingham is right to point out that his suggested solution of a “driving licence” is completely impractical, and is based on a misunderstanding of the current legislation for the protection of patients.2

The licensing system he proposes would be bureaucratic and impossible to administer. It is also unnecessary. The legislation makes it quite clear that the referrer's responsibility is to provide the practitioner with sufficient information to decide whether the examination is justified. Whenever possible, that practitioner should be the radiologist (or nuclear medicine doctor) responsible for performing and reporting the examination, who will hopefully have the requisite knowledge of the radiation hazard and will be able to make an informed judgment.

If the licensing were an administrative nightmare then obtaining written consent for every exposure would bring radiology departments to a halt. The concept of counselling all the anxious patients referred for a chest x ray and confused and alarmed by the information that they are about to receive an exposure of 0.02 mSv, which may, or may not, cause cancer in 30 years' time hardly bears thinking about. There may be a case for this with some of the higher dose procedures, but even here we would need to give it careful thought. Simply stating the absolute level of risk (which we don't actually know with any degree of accuracy) without any attempt to put it into the context of the patient's illness and the benefits to be expected, would be unfair on them, and it would be impossible to do this adequately for more than a small minority.
The Long Term (5-Years) Objective TVT Success Rate Does Not Depend on Predictive Factors at Multivariate Analysis
Authors: Kyu-Sung Lee, Myung-Soo Choo, Chin Kyung Doo, Deok-Hyun Han, Young-Suk Lee, Ji Yoon Kim, Wan Suk Kim, Hee Chang Jung
Journal: European Urology (2007)
The Lung. Clinical Physiology and Pulmonary Function Tests.
Authors: Julius H. Comroe
Journal: Annals of Internal Medicine (1963)

Since World War II there has rapidly developed a scheme of pulmonary-function tests which quantitatively analyze the patient's ability to breathe. This development is analagous to that of liver-function tests and kidney-function tests. "The Lung: Clinical Physiology and Pulmonary Function Tests," by Dr. Julius Comroe and co-workers, at the University of Pennsylvania, presents the system of analysis of the patient with breathing difficulties which has been in use in 1955, gives the reason behind individual procedures, and shows clinical situations in which the tests are helpful. The recent uses of alveolar ventilation, ventilation-blood flow ratios, blood-gas diffusion, and compliance studies are handled, as well as older ideas about lung volumes and blood gas analysis. Physicians who have been appalled by the complicated mathematical presentation of pulmonary physiology in review papers will be pleased with the frequent use of understandable diagrams. Ten case studies illustrate application of the tests. An appendix
Early CMV Reactivation Still Remains a Cause of Increased Transplant Related Mortality in the Current Era: A CIBMTR Analysis
Authors: Muthalagu Ramanathan, Pierre Teira, Minoo Battiwalla, A. John Barrett, Caroline A Lindemans, Jeffery Auletta, Kwang Woo Ahn, Min Chen, Marcie L Riches, Michael Boeckh
Journal: Blood (2014)
The Effect of Multiple Micronutrient Supplementation on Left Ventricular Ejection Fraction in Patients With Chronic Stable Heart Failure
Authors: Nicholas A. McKeag, Michelle C. McKinley, Mark T. Harbinson, Rebecca L. Noad, Lynn H. Dixon, Ann McGinty, Charlotte E. Neville, Jayne V. Woodside, Pascal P. McKeown
Journal: JACC Heart Failure (2014)

This study sought to investigate the effect of a multiple micronutrient supplement on left ventricular ejection fraction (LVEF) in patients with heart failure. Observational studies suggest that patients with heart failure have reduced intake and lower concentrations of a number of micronutrients. However, there have been very few intervention studies investigating the effect of micronutrient supplementation in patients with heart failure. This was a randomized, double-blind, placebo-controlled, parallel-group study involving 74 patients with chronic stable heart failure that compared multiple micronutrient supplementation taken once daily versus placebo for 12 months. The primary endpoint was LVEF assessed by cardiovascular magnetic resonance imaging or 3-dimensional echocardiography. Secondary endpoints were Minnesota Living With Heart Failure Questionnaire score, 6-min walk test distance, blood concentrations of N-terminal prohormone of brain natriuretic peptide, C-reactive protein, tumor necrosis factor alpha, interleukin-6, interleukin-10, and urinary levels of 8-iso-prostaglandin F2 alpha. Blood concentrations of a number of micronutrients increased significantly in the micronutrient supplement group, indicating excellent compliance with the intervention. There was no significant difference in mean LVEF at 12 months between treatment groups after adjusting for baseline (mean difference: 1.6%, 95% confidence interval: −2.6 to 5.8, p = 0.441). There was also no significant difference in any of the secondary endpoints at 12 months between treatment groups. This study provides no evidence to support the routine treatment of patients with chronic stable heart failure with a multiple micronutrient supplement. (Micronutrient Supplementation in Patients With Heart Failure [MINT-HF]; NCT01005303)
Rate of surgery for gall stones is increasing
Authors: C.-M. Lam, A. Cuschieri, F. E Murray
Journal: BMJ (1995)

EDITOR,--In their review on the treatment of gall stones N Tait and J M Little suggest that the selection of patients for cholecystectomy has not been changed by the introduction of laparoscopic surgery.1 Our work2 and studies by others,3 4 5 however, have shown that the total cholecystectomy rate has increased by an average of 25% since the introduction of laparoscopic cholecystectomy.

The causes for this increased rate have not …
Plasma clozapine levels and clinical response for treatment-refractory schizophrenic patients
Authors: M H Kronig, R A Munne, S Szymanski, A Z Safferman, S Pollack, T Cooper, J M Kane, J A Lieberman
Journal: American Journal of Psychiatry (1995)

The purpose of this study was to determine if plasma clozapine levels were associated with treatment response.To examine this question, neuroleptic nonresponsive patients with schizophrenia or schizoaffective disorder were given clozapine, which was titrated to 500 mg/day by day 14 of treatment, and the dose was held fixed at least through day 21. Subsequently, clozapine doses were adjusted as clinically indicated, up to a maximum of 900 mg/day. Plasma clozapine levels were obtained at weeks 3 and 6, and standard clinical ratings (Brief Psychiatric Rating Scale [BPRS] and Clinical Global Impression) were done at baseline and at weeks 3 and 6.Data from 45 subjects were analyzed. There were no correlations between plasma clozapine levels and change in BPRS scores at treatment weeks 3 and 6. However, when the subjects were classified as responders or nonresponders, therapeutic response was associated with clozapine blood levels above 350 ng/ml.This study suggest that clozapine blood levels are correlated with clinical response.
Abstract 16433: A Novel Approach to Measure Distal Pulmonary Vascular Remodeling in Pulmonary Aterial Hypertension: Microfil® Perfused Lungs and CT-Scan Analysis in Different Pulmonary Hypertension Models
Authors: Marjorie Barrier, Audrey Courboulin, Mathilde Chapolard, Maria Helena Jacob, Malik Bisserier, Caroline Lambert, Sébastien Bonnet
Journal: Circulation (2011)

Background: Pulmonary arterial hypertension (PAH) is a vascular disease that is restricted to small pulmonary arteries (PA). PAH is characterized by distal PA remodeling, elevating pulmonary vascular resistance, and decreasing blood lung perfusion. This causes right ventricular failure and premature death. This distal PA remodeling is mainly caused by pulmonary arterial smooth muscle cells proliferation phenotype. In addition, the most dramatic pathological findings in PAH are the plexiform lesions, which are usually found at branch points, often distal to an occluded arteriole further decreasing lung perfusion. However, in vivo assessment of lung perfusion abnormalities in PAH remains limited, indirect or restrictive to lung histology. We hypothesize that CT-scan Microfil®-perfused lung angiogram is an efficient way in assessing lung perfusion and thus overall lung microcirculation abnormalities accounting for pulmonary vascular remodeling. Methods/Results: Microfil®-CT angiograms were perform in control...