tbuckley/cabot-search huggingface dataset:
Influenza Vaccine in High-Risk Cardiovascular Diseases—Define the Target—Reply
Authors: Alexander Peikert, Scott D. Solomon, Orly Vardeny
Journal: JAMA Cardiology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Comparison of Outcomes for Patients Treated by Allopathic vs Osteopathic Surgeons
Authors: Tara A. Russell, Ryu Yoshida, Mauranda Men, Ruixin Li, Melinda Maggard-Gibbons, Christian de Virgilio, Marcia M. Russell, Yusuke Tsugawa
Journal: JAMA Surgery (2024)

There are 2 degree programs for licensed physicians in the US: allopathic medical doctorate (MD) and osteopathic doctorate (DO). However, evidence is limited as to whether outcomes differ between patients treated by MD vs DO surgeons.
Outcomes Following Resection of Stage I to III Thymic Tumors in High-Volume Centers
Authors: Sara Sakowitz, Syed Shahyan Bakhtiyar, Saad Mallick, Jane Yanagawa, Peyman Benharash
Journal: JAMA Surgery (2024)

This cohort study examines the association of patient outcomes following resection of stage I to III thymic tumors with whether the procedure was conducted at high-volume centers.
Perspectives on Artificial Intelligence–Generated Responses to Patient Messages
Authors: Jiyeong Kim, Michael L. Chen, Shawheen J. Rezaei, April S. Liang, Susan M. Seav, Sonia Onyeka, Julie J. Lee, Shivam C. Vedak, David Mui, Rayhan A. Lal, Michael A. Pfeffer, Christopher Sharp, Natalie M. Pageler, Steven M. Asch, Eleni Linos
Journal: JAMA Network Open (2024)

This cross-sectional study of patient queries in US electronic health records examines laypersons’ satisfaction with answers generated with artificial intelligence (AI) compared with clinician responses, and whether results were concordant with clinician-determined quality of AI responses.
Gut symbiont-derived anandamide promotes reward learning in honeybees by activating the endocannabinoid pathway
Authors: Zhaopeng Zhong, Xiaohuan Mu, Haoyu Lang, Yueyi Wang, Yanling Jiang, Yuwen Liu, Qian Zeng, Siyuan Xia, Baotong Zhang, Zilong Wang, Xiaofei Wang, Hao Zheng
Journal: Cell Host & Microbe (2024)
The Potential Outcome-Modification Influences Introduced by ESKD Life Plan on eGFR Slopes
Authors: Kuo-Chin Hung, Chia-Ter Chao
Journal: Journal of the American Society of Nephrology (2024)

In a recent study published in JASN, Tabcheh et al. conducted an intriguing study investigating the influences of arteriovenous (AV) access creation on the slope of eGFR decline in patients with advanced CKD from the Chronic Kidney Disease-Renal Epidemiology and Information (CKD-REIN) cohort.1 They demonstrated that the inflection point in the eGFR slope occurred 8.1 months before AV access creation, suggesting that factors other than AV access creation contributed to retarding kidney function deterioration. We believe that their findings are noteworthy and wish to provide our thoughts on plausible contributors to this phenomenon in those with advanced CKD. First of all, the process of ESKD life planning can influence patients' eGFR trajectory. ESKD life planning aims to establish a strategy for patients to manage life before and after ESKD by introducing treatment modality choices and subsequent arrangements within the patients' foreseeable lifespan through shared decision making.2 This planning considers patients' individual medical conditions, functional status, preferences, family and social support background, and life goals. Existing literature shows that shared decision making improves CKD patients' motivation, satisfaction, and adherence to treatments, which helps to prevent CKD-related complications and further kidney function worsening.3 Moreover, when patients with CKD are motivated to monitor their physical and mental health, they may emphasize mitigating adverse influences from detrimental phenotypes such as sarcopenia and frailty, both of which can aggravate kidney outcomes. As ESKD life planning is frequently initiated during late CKD stages (4–5), there may be a lag between the start of planning and its indirect outcome benefits. This is partially supported by the approximate eGFR level (approximately 17 ml/min per 1.73 m2) when patients are at the inflection point in the study by Tabcheh et al.1 In addition, the involvement of multidisciplinary members during shared decision making, including surgeons, radiologists, nurses, and pharmacists, also assists in preserving kidney function in these patients with CKD. Medication reconciliation is associated with a lower risk of polypharmacy, which increases drug–drug interactions and aggravates patients' health.4 This can be another pathway through which the eGFR decline rate is ameliorated. In conclusion, we commend Tabcheh et al. for their insightful study and suggest that ESKD life planning and multidisciplinary care may play significant roles in the observed inflection point in eGFR decline among patients with advanced CKD.
Trends in Transcatheter Aortic Valve Replacement Outcomes
Authors: Suzanne V. Arnold, Pratik Manandhar, Sreekanth Vemulapalli, Andrzej S. Kosinski, Wayne B. Batchelor, Vinod H. Thourani, Michael J. Mack, David J. Cohen
Journal: JAMA Cardiology (2024)

Importance Although transcatheter aortic valve replacement (TAVR) outcomes in the US have improved substantially since 2011, it is unknown whether these trends have continued since 2019. Objective To examine changes in risk-adjusted TAVR outcomes from 2019 to 2022 and to examine any noteworthy trends over time. Design, Setting, and Participants This cohort study examined data from patients with severe aortic stenosis treated with TAVR at 786 US hospitals between January 1, 2019, and March 31, 2022, included in the Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapies (TVT) Registry. Exposure Patients who underwent TAVR. Main Outcomes and Measures The primary outcome was 30-day mortality, and the secondary outcomes were in-hospital mortality and 30-day composite adverse events. To understand factors explaining these trends, a series of logistic regression models was constructed for each outcome, with time as the primary explanatory variable. After adjusting for changing patent characteristics and procedural factors, a series of exploratory analyses was performed to examine the extent to which these findings could be explained by several plausible hypotheses. Results This study’s analytic cohort included a total of 210 495 patients. Median (IQR) patient age was 79 (73-85) years, and 91 313 patients (43.4%) were female. Median (IQR) STS predicted risk of mortality (PROM) was 3.3% (2.0%-5.3%). There were no significant changes in unadjusted 30-day mortality from quarter 1 of 2019 (2.4%) to the end of quarter 1 of 2022 (2.2%) ( P for trend = .10), with an unadjusted odds ratio (OR) for time of 0.98 per year (95% CI, 0.94-1.01). After adjusting for patient characteristics, the OR increased to 1.05 per year (95% CI, 1.02-1.08), which increased further after adjusting for procedural characteristics to 1.09 per year (95% CI, 1.05-1.13). In exploratory analyses, there were no meaningful changes in the adjusted odds of death after excluding sites that entered the STS/ACC TVT Registry in 2019 or later (OR, 1.09; 95% CI, 1.05-1.13), low-volume sites (OR, 1.09; 95% CI, 1.06-1.13), low-risk patients (OR, 1.11; 95% CI, 1.07-1.15), patients with a bicuspid aortic valve (OR, 1.09; 95% CI, 1.05-1.13), in-hospital deaths (OR, 1.08; 95% CI, 1.03-1.14), or patients who experienced a major vascular complication (OR, 1.09; 95% CI, 1.05-1.12). Conclusions and Relevance In this observational cohort study performing a national analysis of outcomes after TAVR, it was found that risk-adjusted 30-day mortality increased modestly from January 2019 to March 2022. However, no site-level, patient-related, or process-related factors were identified that could explain these findings. Although the absolute increase in risk-adjusted mortality during the study period was relatively small, these findings warrant continued surveillance.
SARS-CoV-2 and Offspring Neurodevelopment—We Don’t Know Yet
Authors: Andrea G. Edlow
Journal: JAMA Network Open (2024)

Eleni G. Jaswa, MD, MSc, MAS; Heather G. Huddleston, MD; Karla J. Lindquist, PhD; Alan H. B. Wu, PhD; Somer L. Bishop, PhD; Young-Shin Kim, MD, MS, MPH, PhD; Amy Kaing, MD; Mary Prahl, MD; Stephanie L. Gaw, MD, PhD; Jamie Corley, BS; Elena Hoskin, MS; Yoon Jae Cho, MD; Elizabeth E. Rogers, MD; Marcelle I. Cedars, MD
Addressing the Escalating Problems That Patients Encounter When Filling Buprenorphine Prescriptions
Authors: Erin L. Winstanley, Angela Gray, Douglas Thornton
Journal: JAMA Psychiatry (2024)

This Viewpoint describes both the current barriers patients face when filling their prescriptions for buprenorphine at pharmacies and a list of proposed fixes requiring changes at the federal, state, insurance, and clinician level.
Genotyping methods to distinguish Plasmodium falciparum recrudescence from new infection for the assessment of antimalarial drug efficacy: an observational, single-centre, comparison study
Authors: Annina Schnoz, Carla Beuret, Maura Concu, Salome Hosch, Liliana K Rutaihwa, Monica Golumbeanu, Christian Nsanzabana
Journal: The Lancet Microbe (2024)
Rapid multiplex PCR panel for pneumonia in hospitalised patients with suspected pneumonia in the USA: a single-centre, open-label, pragmatic, randomised controlled trial
Authors: Abinash Virk, Angel P Strasburg, Kami D Kies, Alexander D Donadio, Jay Mandrekar, William S Harmsen, Ryan W Stevens, Lynn L Estes, Aaron J Tande, Douglas W Challener, Douglas R Osmon, Madiha Fida, Paschalis Vergidis, Gina A Suh, John W Wilson, Nipunie S Rajapakse, Bijan J Borah, Ruchita Dholakia, Katelyn A Reed, Lisa M Hines, Audrey N Schuetz, Robin Patel
Journal: The Lancet Microbe (2024)
Toward Equitable Interventions in Public Mental Health
Authors: Ulrich Reininghaus, Annika S. Reinhold, Stefan Priebe, Christian Rauschenberg, Leonie Fleck, Anita Schick, Frederike Schirmbeck, Inez Myin-Germeys, Craig Morgan, Jessica A. Hartmann
Journal: JAMA Psychiatry (2024)

The field of public mental health is evolving to tackle the profound impact of global challenges such as climate change, migration, and health crises. These issues accentuate health and social inequities, necessitating a focus on how to achieve interventions that are equitable and enhance mental health across all societal strata.
Influenza Vaccine in High-Risk Cardiovascular Diseases—Define the Target
Authors: Alberto Donzelli
Journal: JAMA Cardiology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Poetry, Again, Confronts Death
Authors: Rafael Campo
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of Sensory Regions vs the Rest of the Cortex in Autism
Authors: Jessica Girault
Journal: JAMA Psychiatry (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast JAMA+ AI Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
A randomized clinical trial testing digital mindset intervention for knee osteoarthritis pain and activity improvement
Authors: Melissa A. Boswell, Kris M. Evans, Disha Ghandwani, Trevor Hastie, Sean R. Zion, Paula L. Moya, Nicholas J. Giori, Jennifer L. Hicks, Alia J. Crum, Scott L. Delp
Journal: npj Digital Medicine (2024)

This randomized clinical trial evaluated the effectiveness of short, digital interventions in improving physical activity and pain for individuals with knee osteoarthritis. We compared a digital mindset intervention, focusing on adaptive mindsets (e.g., osteoarthritis is manageable), to a digital education intervention and a no-intervention group. 408 participants with knee osteoarthritis completed the study online in the US. The mindset intervention significantly improved mindsets compared to both other groups (P < 0.001) and increased physical activity levels more than the no-intervention group (mean = 28.6 points, P = 0.001), but pain reduction was not significant. The mindset group also showed significantly greater improvements in the perceived need for surgery, self-imposed physical limitations, fear of movement, and self-efficacy than the no-intervention and education groups. This trial demonstrates the effectiveness of brief digital interventions in educating about osteoarthritis and further highlights the additional benefits of improving mindsets to transform patients' approach to disease management. The study was prospectively registered (ClinicalTrials.gov: NCT05698368, 2023-01-26).
COVID-19-related morbidity and mortality in people with multiple long-term conditions: a systematic review and meta-analysis of over 4 million people
Authors: Shukrat O Salisu-Olatunji, Yogini V Chudasama, Navjot Kaur, Zara Kayani, Babatunde A Odugbemi, Olasope Esther Bolodeoku, Shirley Akua Konnor, Elpida Vounzoulaki, Atanu Bhattacharjee, Radia Fahami, Jonathan Valabhji, Amitava Banerjee, Francesco Zaccardi, Clare L Gillies, Kamlesh Khunti
Journal: Journal of the Royal Society of Medicine (2024)

Objectives To describe the direct impact of coronavirus disease 2019 (COVID-19) infection on morbidity and mortality in people with multiple long-term conditions (MLTCs). Design A systematic review and meta-analysis including observational studies. Setting Studies conducted between 1 January 2020 and 4 May 2023 across 51 countries were identified from five databases. Participants A total of 4,084,469 patients with confirmed COVID-19 infection. Main outcome measures Pooled risk ratios (RRs) for mortality, hospitalisation, severe disease, intensive care unit (ICU) admission and mechanical ventilation were estimated with random effect meta-analysis models. Results A total of 38,356 studies were identified and 111 included. In most (74%) of the studies, MLTCs referred to having two or more long-term conditions. Others described MLTCs by high weighted indices: the Charlson Comorbidity Index in 11% and the Clinical Frailty Score in 7%. Using the National Institutes of Health quality assessment tool for observational studies, the risk of bias was judged as low and moderate in 86 and 25 studies, respectively. Having MLTCs was associated with increased mortality (RR: 2.61 [95% CI: 2.27 to 3.0]); hospitalisation (2.4 [1.92 to 2.99]); severe disease (2.61 [1.92 to 3.54]); ICU admission (1.22 [1.07 to 1.39]) and mechanical ventilation (1.83 [1.18 to 2.84]) compared with those with no MLTCs. Pooled RRs for adverse outcomes were higher in children and young people compared with all age groups. In meta-regression analyses, men were more likely to need ICU admission ( p = 0.013) and mechanical ventilation ( p = 0.002). Conclusions Public health policies, clinical and preventative interventions should prioritise people with MLTCs to minimise direct adverse outcomes from COVID-19 disease.
Assessment of patient satisfaction with dupilumab for chronic rhinosinusitis with nasal polyps
Authors: Aiko Oka, Kengo Kanai, Shoji Matsune, Kei Hosoya, Taro Komachi, Ryosuke Murakami, Kimihiro Okubo, Kojiro Hirano, Isao Suzaki, Tomotaka Shimura, Takatoshi Tokudome, Sho Kanzaki, Ken‐ichiro Wakabayashi, Hiroyuki Ozawa, Yasuhide Okamoto, Kenji Kondo, Hironobu Nishijima, Ami Nishijima, Mitsuhiro Okano
Journal: Allergy (2024)

The data that support the findings of this study are available from the corresponding author upon reasonable request. Data S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Reducing Learning and Psychosocial Disparities in Latino Children with Cancer: A Randomized Intervention Trial
Authors: Sunita K Patel, Seong-Hyeon Kim, Kathleen Ingman, Van Huynh, Heather Huszti, Kimberly Kayser, Grace Mucci, Melissa Balderrama, Laura Bava, Abigail Onderwyzer Gold, Alicia Wuth, Nicole Delgado, Alysia Bosworth, Emily Nishimura, Harneet Hara, Anna Pawlowska, Lisa Mueller, F Lennie Wong
Journal: JNCI Journal of the National Cancer Institute (2024)

We developed a high-intensity parenting intervention (HIP) to help parents support the academic success of childhood cancer survivors (CCSs), who often face post-treatment challenges affecting their school-related functioning. This randomized controlled trial (NCT03178617) evaluated HIP's efficacy compared to lower-intensity, single-session, treatment-as-usual services (LIP) in Latino families. Primary outcomes were parenting efficacy and CCSs' school functioning; secondary outcomes included parenting knowledge and measures of CCSs' academic performance, attention, and functioning outside of school.
Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis
Authors: Seiji Kaji, Stefan A Berghoff, Lena Spieth, Lennart Schlaphoff, Andrew O Sasmita, Simona Vitale, Luca Büschgens, Shreeya Kedia, Martin Zirngibl, Taisiia Nazarenko, Alkmini Damkou, Leon Hosang, Constanze Depp, Frits Kamp, Patricia Scholz, David Ewers, Martin Giera, Till Ischebeck, Wolfgang Wurst, Benedikt Wefers, Martina Schifferer, Michael Willem, Klaus-Armin Nave, Christian Haass, Thomas Arzberger, Sarah Jäkel, Oliver Wirths, Gesine Saher, Mikael Simons
Journal: Immunity (2024)
Assessment of Neutralizing Antibody Response as a Correlate of Protection against Symptomatic SARS-CoV-2 Infections after Administration of two doses of the CoronaVac inactivated COVID-19 Vaccine: A Phase III Randomized Controlled Trial
Authors: Xinhua Chen, Xing Meng, Qianhui Wu, Wey Wen Lim, Qianqian Xin, Benjamin J Cowling, Weining Meng, Hongjie Yu, Dimas Tadeu Covasa
Journal: Journal of Infection (2024)

The emergence of variants of concerns of SARS-CoV-2 highlights the need for comprehensively elucidating the correlates of protection for different COVID-19 vaccine types. Inactivated COVID-19 vaccines are currently amongst the most widely administered vaccines globally. However, investigations into the correlates of protection for inactivated COVID-19 vaccines are relatively rare.
Factors influencing antibiotic use in pets: Insight into pet owners’ knowledge and personal antibiotic use suggests a benefit to cross-sectoral education to combat inappropriate antimicrobial use
Authors: Angela Chow, Seema K Aithal, Huiling Guo, Timothy Chua, Boon Han Teo, Zoe Jane-Lara Hildon
Journal: Clinical Microbiology and Infection (2024)
Privacy Preserving Technology using Federated Learning and Blockchain in protecting against Adversarial Attacks for Retinal Imaging
Authors: Zhen Ling Teo, Xiaoman Zhang, Yechao Yang, Liyuan Jin, Chi Zhang, Stanley Shuoh Jieh Poh, Weihong Yu, Youxin Chen, Jost B Jonas, Ya Xing Wang, Wei-Chi Wu, Chi-Chun Lai, Yong Liu, Rick Siow Mong Goh, Daniel Shu Wei Ting
Journal: Ophthalmology (2024)
Polygenic risk scores stratify breast cancer risk among women with benign breast disease
Authors: Mark E Sherman, Stacey J Winham, Robert A Vierkant, Bryan M Mccauley, Christopher G Scott, Sarah Schrup, Mia M Gaudet, Melissa A Troester, Sandhya Pruthi, Derek C Radisky, Amy C Degnim, Fergus J Couch, Manjeet K Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Pascal Guenel, Therese Truong, Jenny Chang-Claude, Nadia Obi, Kristan J Aronson, Rachel Murphy, Montserrat Garcia-Closas, Stephen Chanock, Thomas Ahearn, Xiaohong Yang, Alison M Dunning, Nasim Mavaddat, Paul D P Pharoah, Douglas F Easton, Celine M Vachon
Journal: JNCI Journal of the National Cancer Institute (2024)

Most breast biopsies are diagnosed as benign breast disease (BBD), with 1.5- to fourfold increased breast cancer (BC) risk. Apart from pathologic diagnoses of atypical hyperplasia, few factors aid in BC risk assessment of these patients. We assessed whether a 313-SNP polygenic risk score (PRS) stratifies risk of BBD patients.