tbuckley/cabot-search huggingface dataset:
Dynamic susceptibility contrast MRI of regional cerebral blood volume in Alzheimer's disease
Authors: G J Harris, R F Lewis, A Satlin, C D English, T M Scott, D A Yurgelun-Todd, P F Renshaw
Journal: American Journal of Psychiatry (1996)

The purpose of this study was to investigate the potential effectiveness of dynamic susceptibility contrast magnetic resonance imaging (MRI) to discriminate elderly patients with Alzheimer's disease from normal matched comparison subjects.Images of regional cerebral blood volume (CBV) were generated from echo-planar MRI with the dynamic susceptibility contrast method in 13 Alzheimer's disease patients and 13 comparison subjects group-matched on age and gender.Temporoparietal cerebral blood volume, expressed as a percentage of the cerebellum value, was reduced 17% bilaterally in the patients with Alzheimer's disease. Blood volume in sensorimotor regions was reduced only 8.5% in the patients. Discriminant function analysis based on left and right temporoparietal measures correctly classified 88.5% of the subjects as patients or comparison subjects. Temporoparietal CBV was reduced even in mildly affected Alzheimer's disease patients (Mini-Mental State scores > 24).Dynamic susceptibility contrast MRI of regional CBV is promising as a nonradioactive, potentially lower-cost alternative to other functional neuroimaging methods for evaluating Alzheimer's disease.
Abstract 3016: Delayed Hyperenhancement Magnetic Resonance Imaging is a Significant Prognostic Factor in Patients with Non-ischemic Left Ventricular Systolic Dysfunction
Authors: Jung Rae Cho, Sungha Park, Byoung Wook Choi, Young Jin Kim, Se-Joong Rim, Eui-Young Choi, Seok-Min Kang, Jong-Won Ha, Namsik Chung, Kyu-Ok Choe, Seung-Yun Cho
Journal: Circulation (2006)
Abstract 12799: Left Ventricular End-Diastolic Pressure Correlates with Right Ventricular End-Diastolic Volume in Patients Following Tetralogy of Fallot Repair
Authors: Matthew C Schwartz, Jonathan J Rome, Matthew A Harris, Mark C Fogel, Andrew C Glatz
Journal: Circulation (2010)

Introduction: Right ventricular dilation is a long-term complication after tetralogy of Fallot (TOF) repair and is associated with poor outcomes. Left ventricular end-diastolic pressure (LVEDP) ≥12...
Abstract 5999: Optical Coherence Tomography Findings At Two Years Follow Up In Fully Biodegradable Everolimus Eluting Stents
Authors: Nieves Gonzalo, Patrick W Serruys, Rafael Freire, Jurgen Ligthart, Wim vd Giessen, Nico Bruining, Evelyn Regar
Journal: Circulation (2008)

Fully biodegradable stents may avoid the potential long-term complications of metallic drug-eluting stents such as late and very late stent thrombosis. We sought to evaluate the structural changes in a bioabsorbable DES and its interaction with the coronary vessel wall over time using optical coherence tomography (OCT). We investigated 14 consecutive patients undergoing implantation of a bioabsorbable everolimus-eluting coronary stent (BVS: Abbott Laboratories, IL, USA), composed of a poly-L-lactic acid backbone, coated with a degradable polymer/everolimus matrix. OCT (LightLab Imaging, Inc., Westford, MA) was performed immediately after stent implantation, at 6 months and at 24 months follow-up. All patients tolerated OCT imaging without complications. At baseline, OCT could detect the interface between the BVS stent and other tissues or fluid, but the inside of the strut appeared black, giving a unique box appearance. After 6 months, the struts were still clearly visible; however, their optical properties had changed considerably. In patients undergoing two years follow up (n=5, full dataset will be available at time of presentation) the majority of struts was not visible anymore and all visible struts were embedded into the vessel wall with complete tissue coverage. In contrast to 6months follow-up, at 2 years no intraluminal thrombi or dissections were visible. At 2 years follow-up the majority of stent struts were not visible by OCT. All the visible struts were covered and apposed. The lumen surface was smooth without intraluminal thrombi or dissections.
Abstract 21205: Reduction of Functional Mitral Regurgitation via Percutaneous Annuloplasty Associated With Exercise Improvement and Reverse Remodeling
Authors: Tom Siminiak, Michael Haude, Uta C Hoppe, Jerzy Sadowski, janusz Lipiecki, Jean Fajadet, Nawzer Mehta, David G Reuter
Journal: Circulation (2010)

Background: Functional Mitral Regurgitation (FMR) contributes to both ventricular remodeling and exercise intolerance. Whether percutaneous reduction in FMR is sufficient to confer functional benef...
Inheritance in Erythropoietic Protoporphyria: A Common Wild-Type Ferrochelatase Allelic Variant With Low Expression Accounts for Clinical Manifestation
Authors: Laurent Gouya, Herve Puy, Jerôme Lamoril, Vasco Da Silva, Bernard Grandchamp, Yves Nordmann, Jean-Charles Deybach
Journal: Blood (1999)
DIABETIC LIPEMIA
Authors: 恵子 小林, 朋也 梅園, 真弓 丸山, 麻記子 阿部, 貴子 小林, 麻祐子 加藤, 雅晃 宮内, 直之 山本, 守次 木村, 雅夫 豊田, 光則 谷亀, 大輔 鈴木
Journal: JAMA (1922)
Platelet secretion induced by phorbol esters stimulation is mediated through phosphorylation of MARCKS: a MARCKS-derived peptide blocks MARCKS phosphorylation and serotonin release without affecting pleckstrin phosphorylation*
Authors: Abdelbaset Elzagallaai, Sergio D. Rosé, José-Marı́a Trifaró
Journal: Blood (2000)
Thiotepa-Based Vs TBI-Based Myeloablative Conditioning Prior To Allogeneic Stem Cell Transplantation (HSCT) For Acute Myeloid Leukemia (AML) In First Complete Remission (CR1): A Retrospective Analysis From The ALWP Of The EBMT
Authors: Sandra Eder, Myriam Labopin, William Arcese, Reuven Or, Ignazio Majolino, Andrea Bacigalupo, Gennaro de Rosa, Liisa Volin, Dietrich Beelen, Hendrik Veelken, Nicolaas PM Schaap, Jurgen H Kuball, Jan Cornelissen, Arnon Nagler, Mohamad Mohty
Journal: Blood (2013)
Donor-Derived Anti-CD19 Chimeric-Antigen-Receptor-Expressing T Cells Cause Regression Of Malignancy Persisting After Allogeneic Hematopoietic Stem Cell Transplantation
Authors: James N Kochenderfer, Mark E. Dudley, Robert O. Carpenter, Sadik H Kassim, Jeremy J. Rose, William Telford, Frances T Hakim, David Halverson, Daniel H. Fowler, Nancy M. Hardy, Anthony Mato, Dennis D. Hickstein, Juan Gea-Banacloche, Steven Z. Pavletic, Claude Sportes, Irina Maric, Steven Feldman, Brenna G Hansen, Jennifer Wilder, Bazetta Blacklock-Schuver, Bipulendu Jena, Michael Bishop, Steven A. Rosenberg, Ronald E. Gress
Journal: Blood (2013)
Abstract 212: Advantage of CPR-First Over Call-First Basic Life Support Actions in Out-of-Hospital Cardiac Arrest of Noncardiac Etiology and Young Adults/Children
Authors: Hose Iwasaki, Takahisa Kamikura, Testuo Maeda, Minoru Kubo, Yutaka Takei, Masaaki Hashimoto, Hideo Inaba
Journal: Circulation (2014)

Aim: To assess the benefit of immediate call-first or CPR-first basic life support (BLS) in promoting a better outcome of out-of-hospital cardiac arrest (OHCA). Methods: From the nation-wide database of 2005 to 2012, we extracted bystander-witnessed OHCAs in which both emergency call and CPR were performed by bystanders on their own initiative (without instruction over telephone) within 6 min of witnessing patient collapse. These cases were categorized into the following four groups; immediate Call+CPR group (N=10,195 ,emergency call and/or CPR within 2 min of witness, call-CPR time interval = 0 or 1 min), immediate Call-First group (N=1,820 , emergency call within 2 min of witness, call-CPR interval = 2[[Unable to Display Character: &amp;#8210;]]4 min), immediate CPR-First group (N=5,446 , bystander CPR within 2 min of witness, CPR-call interval =2[[Unable to Display Character: &amp;#8210;]]4 min), the delayed Call/CPR group (N=4,671, the remaining cases). We compared the rates of neurologically favorable survival at 1-month among the four groups for all OHCAs and subgroups of OHCAs. Results: The overall survival rate was highest in Call-First group and lowest in delayed Call/CPR group (Figure). The rate of Call-First group was significantly higher than that of CPR-First group in OHCAs of presumed cardiac etiology (17.2% vs. 14.1%, unadjusted OR; 95% CI, 1.26; 1.05[[Unable to Display Character: &amp;#8210;]]1.52). The rate of CPR-First group was significantly higher than that of Call-First group in OHCAs of presumed non-cardiac etiology (7.7% vs. 5.0%, 1.59; 1.11[[Unable to Display Character: &amp;#8210;]]2.33) and young adults/children (age&lt;35y, 32.8% vs. 17.8%, 2.25; 1.33[[Unable to Display Character: &amp;#8210;]]3.95). Multiple logistic regression analysis confirmed the results of univariate analyses and disclosed that delayed Call/CPR is associated with poor outcomes. Conclusions: The immediate (within 2 min) CPR-first BLS action followed by emergency call without a large (&gt;4 min) delay may be recommended when a single bystander having a fundamental skill to initiate CPR witnesses OHCAs of non-cardiac etiology and young adults/children.
Retrospective study of 2,200 involuntary psychiatric admissions and readmissions
Authors: V R Sanguineti, S E Samuel, S L Schwartz, M R Robeson
Journal: American Journal of Psychiatry (1996)

The authors describe demographic data, the distribution of diagnoses, and comorbid psychoactive substance use in a large sample of patients involuntarily admitted to a psychiatric hospital from multiple crisis centers and explore the relative roles these variables may play in service utilization and admission rates.Data on demographic characteristics and comorbid psychoactive substance use in 2,200 consecutive involuntary hospital admissions of 1,755 psychiatric patients were gathered. Pertinent demographic and comorbidity data at first admission for the 1,755 patients, 314 of whom were admitted more than once, were analyzed; then the data for the 1,441 single-admission patients and the data at first admission for the 314 patients who had multiple admissions were compared. Finally, the diagnostic distribution and comorbid psychoactive substance use in all 2,200 admissions were investigated, with attention to a subgroup of 88 high-risk patients (those with three or more admissions) who represented a total of 307 admissions.Specific demographic characteristics were represented in the patient group at a high level of statistical significance. The diagnosis of schizophrenia was significantly overrepresented. Schizophrenia and psychosis not elsewhere classified clustered in the subgroup with a high risk of readmission.The results suggest a specific profile for the patient with heightened risk of hospital admission: a young, unmarried, African American male who has schizophrenia without comorbid substance abuse. An effect size data analysis identified marital status and a diagnosis of schizophrenia as the variables associated with the greatest likelihood of admission. Unexpectedly, the impact of comorbid psychoactive substance use was relatively modest and showed a uniform distribution among diagnostic groups.
Abstract 835: Downregulation Of Cardiomyocyte-enriched Micrornas Contributes To Altered Gene Expression In Heart Failure
Authors: Sadakatsu Ikeda, Sek Won Kong, Jun Lu, Egbert Bisping, Natalya Bodyak, Kyu-Ho Lee, Qing Ma, Peter M Kang, Burkert Pieske, Paul D Allen, Todd Golub, William T Pu
Journal: Circulation (2007)

Background: MicroRNAs (miRNAs) are a novel class of non-coding RNAs that regulate gene expression posttransciptionally. Altered miRNA expression has been implicated in diverse human diseases such as cancer. Accumulating evidence suggests the importance of miRNAs in the heart. However, the contribution of miRNAs to heart disease remains incompletely understood. Methods and Results: We measured the expression of 261 miRNAs in heart failure resulting from transgenic overexpression of calcineurin. 59 miRNAs were confidently detected in the heart, and 11 miRNAs belonging to 6 families (miR-1, -15, -30, -133, -195, -208) were downregulated compared to non-transgenic control (Welch’s t-test nominal p&lt;0.05, false discovery rate &lt;0.001). The results were validated by qRTPCR. There was no upregulated miRNA. Four of these miRNAs (miR-1, -30, -133, -208) were enriched in a purified cardiomyocyte preparation, compared to non-myocytes. Downregulation of these four miRNAs was reproduced in purified failing versus non-failing cardiomyocytes. This excluded artifactual downregulation from reduced myocyte fraction in failing hearts. The remaining two miRNAs (miR-15, and -195) were exclusively expressed in non-cardiomyocytes and did not changed in failing cardiomyocytes. Next, we used Affymetrix expression profiling to show that the predicted targets of these downregulated miRNAs were disproportionately upregulated compared to the entire transcriptome (Fisher’s exact p &lt; 0.001). This suggests an association between downregulation of these miRNAs and upregulation of predicted target genes in heart failure. One particularly intriguing target of the predominant cardiac microRNA miR-1 is calmodulin, a key regulator of calcium signaling. We showed that calmodulin and downstream calmodulin signaling to NFAT is regulated by miR-1 in cultured cardiomyocytes. Conclusion: Our results indicate that altered expression of cardiomyocyte-enriched miRNAs may contribute to abnormal gene expression in heart failure. The regulation of calmodulin and calcium signaling by miR-1 suggests a mechanism by which miR-1 may regulate heart function.
Basal cell-like signature is an independent prognostic factor in triple-negative breast cancer
Authors: Y. Yamamoto, M. Ibusuki, T. Kawasoe, M. Nakano, A. Sueta, M. Hayashi, H. Iwase
Journal: Journal of Clinical Oncology (2008)

22184 Background: Triple-negative (TN) breast cancer, ER(−), PgR(−) and HER2(−) subtype, has poor prognosis. TN cancer consisted of two subtypes, with or without basal-cell like signature (BC). The aim of this study is to clarify clinical and biological characteristics of TN cancer with or without BC. Methods: We examined, by IHC analysis, expression of CK5/6 and EGFR in TN breast cancer. BC was defined as CK5/6 positive and/or EGFR positive, and non-BC was defined as no expression of those two factors. We studied the correlation between the presence of basal-cell like signature and several factors related to tumor progression. We also studied the prognostic value of BC and other biological markers in TN cancer. Results: In the 39 cases of operable TN breast cancer examined, BC was detected in 15 (38.5%) cases and non-BC was detected in 24 (61.5%) cases. BC marginally correlated with nodal status (p=0.0568). BLF was also marginally associated with increased microvessel density (p=0.050) and hypoxia-inducible factor-1α (p=0.074). No association was detected BC and other biological markers. Patients who had BC in TN cancer showed shorter disease-free survival (p=0.001) and overall survival (p=0.0106) than those lacking BC. BC was an independent prognostic factor in TN cancer (Cox regression, p=0.0361) Conclusions: These findings suggest that TN cancer was divided two types of cancer from a prognostic value. It is necessary to development of novel treatment strategy for TN cancer with basal-cell like signature. No significant financial relationships to disclose.
SOME ASPECTS OF CELL PHYSIOLOGY
Authors: W. J. V. Osterhout
Journal: Annals of Internal Medicine (1933)

Article1 September 1933SOME ASPECTS OF CELL PHYSIOLOGYW. J. V. OSTERHOUTW. J. V. OSTERHOUTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-3-396 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAll agree that progress in medicine depends on accurate knowledge of the fundamental laws which govern all life processes. The study of these laws is the province of General Physiology, whose rise and development have been most gratifying, particularly since it has made use of the rapid advances of chemistry and physics.In such studies it seems best to avoid the complexities of higher organisms and to attack first of all the simpler problems presented by single cells. This plan has met with a good deal of success, so that General Physiology is largely concerned with the study of the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Read at the Montreal Meeting of the American College of Physicians, February 6, 1933.From the Rockefeller Institute for Medical Research, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBIBLIOGRAPHYBIBLIOGRAPHY 1 September 1933Volume 7, Issue 3Page: 396-400KeywordsCell physiology ePublished: 1 December 2008 Issue Published: 1 September 1933 PDF downloadLoading ...
Tuberculous Peritonitis in Association with Pancytopenia and Pseudo-Obstruction of the Colon
Authors: N Couse, D Tyrrell, N McMurray, W A Tanner
Journal: Journal of the Royal Society of Medicine (1987)

We report the case of a 72-year-old woman with tuberculous peritonitis, complicated by the unusual association of pancytopenia and pseudo-obstruction of the colon.
Abstract 5451: Deficiency of Glutathione Peroxidase-3 Promotes Platelet Activation <i>in vivo</i>
Authors: Richard C Jin, Christopher E Mahoney, Laura Coleman, Filomena G Ottaviano, Yingyi Zhang, Diane E Handy, Joseph Loscalzo
Journal: Circulation (2008)

Plasma glutathione peroxidase (GPx-3) is a selenocysteine-containing protein with antioxidant properties. GPx-3 plays an important role in plasma against oxidant stress by scavenging reactive oxygen species. A deficiency of this enzyme has been associated with platelet dependent thrombosis. We recently developed an animal model to assess platelet function in GPx-3 deficient mice. We hypothesized that GPx-3 deficiency induces platelet activation in vivo . GPx-3 (−/−) mice showed an attenuated bleeding time compared with wild-type mice (94.5 ± 28.8 s versus 153.4 ± 32.3, P&lt;0.05). We also noted an increase in the plasma levels of soluble P-selectin, a marker of platelet activation and prothrombotic activity, in GPx-3 (−/−) mice compared with wild-type mice (137.8 ± 12.3 ng/ml plasma versus 101.5 ± 8.8, P&lt;0.05). Cyclic GMP, a key intracellular second messenger molecule and marker for activation of soluble guanylyl cyclase by nitric oxide, was decreased in the plasma of GPx-3 (−/−) mice compared with wild-type mice (5.38 ± 1.75 pmol/ml plasma versus 23.67 ± 3.59, P&lt;0.001), consistent with less bioactive NO in GPx-3 (−/−) mice. ADP was infused into the right ventricle of mice to induce platelet aggregation in the pulmonary vasculature; this assay resulted in higher pulmonary artery pressure in GPx-3 (−/−) compared with wild-type mice suggesting a more robust platelet activation response in the GPx-3 (−/−) mice. To confirm this interpretation, histological sections from the pulmonary vasculature of GPx-3 (−/−) compared with wild-type mice showed increased thrombi per 7.5 mm 2 section normalized to wild-type mice based on staining intensity for P-selectin (1.7 ± 0.4 versus 1.0 ± 0.1, P&lt;0.001), as well as a higher percentage of occluded vessels (0.82 ± 0.16 % versus 0.54 ± 0.21, P&lt;0.05). These findings demonstrate that GPx-3 deficiency causes platelet activation resulting in a prothrombotic state. These data illustrate the importance of this plasma antioxidant enzyme in regulating platelet activity and platelet-dependent thrombosis.
Thyroid Antagonists (Perchlorate, Thiocyanate, and Nitrate) and Childhood Growth in a Longitudinal Study of U.S. Girls
Authors: Nancy A. Mervish, Ashley Pajak, Susan L. Teitelbaum, Susan M. Pinney, Gayle C. Windham, Lawrence H. Kushi, Frank M. Biro, Liza Valentin-Blasini, Benjamin C. Blount, Mary S. Wolff
Journal: Environmental Health Perspectives (2015)

Perchlorate, thiocyanate, and nitrate are sodium/iodide symporter (NIS) inhibitors that block iodide uptake into the thyroid, thus affecting thyroid function. Thyroid dysfunction can adversely affect somatic growth and development in children. To our knowledge, no studies have examined effects of NIS inhibitors on body size measures.We investigated associations between NIS inhibitors and childhood growth in 940 girls from the Puberty Study of the Breast Cancer and Environment Research Program.Urine samples collected from girls 6-8 years of age at enrollment (2004-2007) from New York City, greater Cincinnati, Ohio, and the Bay Area in California were analyzed for NIS inhibitors and creatinine (C). The longitudinal association between NIS inhibitors and anthropometric measures [height, waist circumference, and body mass index (BMI)] during at least three visits was examined using mixed effects linear models, adjusted for race and site.Compared with girls in the low-exposure group (3.6, 626, and 500 mg/gC, median perchlorate, thiocyanate, and nitrate, respectively) girls with the highest NIS inhibitor exposure (9.6, 2,343, and 955 mg/gC, median perchlorate, thiocyanate, and nitrate, respectively) had slower growth in waist circumference and BMI but not height. Significant differences in the predicted mean waist circumference and BMI between the low- and high-exposure groups were observed beginning at 11 years of age.Higher NIS inhibitor exposure biomarkers were associated with reductions in waist circumference and BMI. These findings underscore the need to assess exposure to NIS inhibitors with respect to their influence on childhood growth.Mervish NA, Pajak A, Teitelbaum SL, Pinney SM, Windham GC, Kushi LH, Biro FM, Valentin-Blasini L, Blount BC, Wolff MS, for the Breast Cancer and Environment Research Project (BCERP). 2016. Thyroid antagonists (perchlorate, thiocyanate, and nitrate) and childhood growth in a longitudinal study of U.S. girls. Environ Health Perspect 124:542-549; http://dx.doi.org/10.1289/ehp.1409309.
Abstract 1784: Mir-199a Is A Key Regulator Of Hif-1alpha And An Inhibitor Of Hypoxia-induced Apoptosis
Authors: Shweta Rane, Minzhen He, Danish Sayed, Chull Hong, Maha Abdellatif
Journal: Circulation (2008)

MicroRNAs (miRNA) are touted to be fundamental posttranscriptional regulators of gene expression. They are differentially regulated during health and disease states with a major impact on cellular functions. We found that miR-199a is upregulated (4.8 ± 1 fold) during compensatory cardiac hypertrophy, returning to basal levels in the failing heart, and is virtually undetectable during cardiac ischemia. The response of miR-199a to ischemia is rapid through posttranscriptional inhibition of its processing. To determine its targets we analyzed myocytes overexpressing miR-199a by using an antibody array analysis, the outcome of which unequivocally indicated an antiapoptotic function of this miRNA. Target prediction software revealed hypoxia-inducible factor 1 alpha (Hif-1α) as one of its potential targets. We confirmed this by protein expression, luciferase-miR-199a target reporter, and recombinant Hif-1α gene expression under hypoxic conditions in cardiac myocytes. The results show that miR-199a inhibited hypoxia-induced Hif-1α &gt; 70%, and vice versa, knockdown of miR-199a by a miR-199a ‘eraser’ resulted in its upregulation (1.8 fold). Hif-1α, which is undetectable during normoxia and induced by hypoxia, mediates hypoxia-induced apoptosis through a p53-dependent pathway. MiR-199a overexpression in myocytes exposed to anoxia or ischemia resulted in inhibition of Hif-1α expression, as well as, &gt;80% inhibition of the increase in p53. Moreover, miR-199a inhibited hypoxia-induced expression of caspase-6, caspase-9, caspase-12, and caspase-3 activity (~60%). To determine if the protective effect of miR-199a was indeed mediated through inhibition of Hif-1α, we co-delivered a miR-199a-indepndent Hif-1α construct to the myocytes. This resulted in complete reversal of the miR-199a effect on anoxia-induced p53 expression and its downstream caspase effectors. Thus, our results indicate that downregulation of miR-199a by hypoxia is necessary for enhancing expression of Hif-1α and its downstream apoptosis effector p53. Moreover, we show that replenishing miR-199a protects the myocytes against ischemia- or hypoxia-induced apoptosis.