tbuckley/cabot-search huggingface dataset:
Abstract 18979: Early Termination of Adjuvant Trastuzumab Associated with Cardiovascular Events in Older Women with Breast Cancer
Authors: Jersey Chen, Jessica Long, Arti Hurria, Cynthia Owusu, Richard Steingart, Cary Gross
Journal: Circulation (2012)

Background: Biologic therapies for breast cancer such as trastuzumab, (i.e. Herceptin© [H]) increase risk of cardiovascular (CV) events such as heart failure (HF) in clinical trials. However, it is unknown how often H therapy is terminated early (i.e. &lt; 1yr), and which CV complications are associated with early termination. Methods: Using Medicare data linked with SEER cancer registry data from 2000 through 2007, we identified women age 67-94 with stage I-III breast cancer who started H within 90 days of completing adjuvant chemotherapy. Completion of H was defined as &gt;=9 months of continuous H treatments with no delay between H treatments &gt;3 months. We assessed factors contributing to completion of H including age, race, cancer characteristics, and comorbidities. CV events occurring +/- 3 months from last H treatment were ascertained from billing claims. Results: The sample included 294 older women (mean age 71.5 years) without CV events within the year prior to initiation of H. Approximately 79.3% (233) patients completed at least 9 months of H. Early termination of H was significantly associated with any CV complications (27.9% v 8.6%, p&lt;.001), particularly HF or cardiomyopathy (6.6% v 0.4%, p&lt;.001), p=.02) and atrial fibrillation [AF] (8.2% v 2.1%, p=0.02) Conclusion: Early termination of H is common among older women, and associated with higher rates of cardiovascular events. Preventing CV complications such as AF may improve survival in patients with breast cancer by increasing the likelihood of receiving the recommended course of H therapy. Funding(This research has received full or partial funding support from the American Heart Association)
Teeth, Diet and Health.
Authors: Kurt Hermann Thoma
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tuberculosis in the Child and the Adult: A Discussion of Pathologic Anatomy, Pathologic Physiology, Immunology, Diagnosis and Treatment
Authors: Francis Marion Pottenger
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Skiascopy and Its Practical Application to the Study of Refraction.
Authors: Edward Jackson
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2011 Update
Authors: Sidney C. Smith, Emelia J. Benjamin, Robert O. Bonow, Lynne T. Braun, Mark A. Creager, Barry A. Franklin, Raymond J. Gibbons, Scott M. Grundy, Loren F. Hiratzka, Daniel W. Jones, Donald M. Lloyd-Jones, Margo Minissian, Lori Mosca, Eric D. Peterson, Ralph L. Sacco, John Spertus, James H. Stein, Kathryn A. Taubert
Journal: Journal of the American College of Cardiology (2011)
Abstract 13640: Dapagliflozin Lowers HbA1c, Systolic Blood Pressure and Serum Uric Acid in Patients With Type 2 Diabetes and Hypertension, Regardless of Class of Concomitant Antihypertensive Therapy
Authors: Michael A Weber, Traci A Mansfield, Nayyar Iqbal, Shamik J Parikh, Agata Ptaszynska
Journal: Circulation (2014)

Hypertension (HTN) in Type 2 diabetes (T2D) is often treated with an ACEi/ARB + additional antihypertensives agents (AHTs). Dapagliflozin (DAPA) is an inhibitor of sodium glucose co-transporter 2, reducing hyperglycemia in T2D by increasing urinary glucose excretion. This is associated with weight reduction, osmotic diuresis and serum uric acid reduction, all of which may contribute to BP lowering. This Phase 3 study assessed 12 weeks of DAPA 10 mg (N=225) or placebo (PBO; N=224) in T2D patients (HbA1c 7.0-10.5%) with HTN (seated SBP / DBP 140 - &lt;165 / 85 - &lt;105 mmHg) receiving glucose-lowering drugs, an ACEi/ARB, + an additional AHT: β-blockers (27%), Ca-channel blockers (CCBs; 27%), thiazide/thiazide-like diuretics (diuretics; 44%) or α-adrenergic antagonists (α-AAs; 1%). Main results were presented previously. Here we describe treatment effects according to the additional AHT (α-AA group not analyzed due to small sample size). Patients were randomized to DAPA 10 mg or PBO, stratified by insulin use and diuretics vs CCBs/β-blockers/α-AA. Baseline characteristics were similar for DAPA vs PBO. Reduction in HbA1c and mean 24-hour ambulatory SBP was greater with DAPA vs PBO overall, and appeared greater with DAPA vs PBO in all AHT sub-groups (Fig). Reduction in seated SBP was greater with DAPA overall (diff vs PBO; –4.28 [95% CI: –6.54, –2.02] mmHg) and also appeared greater with DAPA in sub-groups (diff vs PBO: β-blockers –5.76 [–10.28, –1.23]; CCB –5.13 [–9.47, –0.79]; diuretics –2.38 [–6.16, 1.40] mmHg). Serum uric acid decreased more with DAPA overall (diff vs PBO; –0.40 [95% CI: –0.57, –0.23]), and was observed to decrease more with DAPA in sub-groups (diff vs PBO: β-blockers –0.62 [–0.95, –0.29]; CCBs –0.33 [–0.65, –0.01]; diuretics –0.22 [–0.49, 0.05] mg/dL). DAPA was well tolerated; AEs were similar for DAPA (44%) vs PBO (42%). In summary, regardless of the concomitant AHT, DAPA reduced HbA1c, SBP and serum uric acid vs PBO in patients with uncontrolled T2D and HTN.
A study of DSM-III schizophreniform disorder
Authors: D L Fogelson, B M Cohen, H G Pope
Journal: American Journal of Psychiatry (1982)

Using five methods of validation the authors evaluated six patients satisfying DSM-III criteria for schizophreniform disorder. These patients did not differ importantly from patients with affective disorders but differed markedly from schizophrenic patients in past psychiatric history, family history, acute treatment response, short-term course, and dexamethasone suppression test results. The findings suggest that schizophreniform disorder, as defined by DSM-III, may not be a valid entity separate from affective disorder and that acuteness of onset, even in the absence of affective symptoms, implies the presence of affective disorder. The authors suggest that a diagnosis of schizophreniform disorder should not exclude patients from treatment with lithium and antidepressants.
"Burnout" in group home houseparents
Authors: J W Thompson
Journal: American Journal of Psychiatry (1980)

Forty-seven houseparents of group homes for emotionally disturbed adolescents completed questionnaires measuring "burnout." There were profound differences between male and female subjects; for men, higher burnout scores were significantly correlated with higher salaries, screening prospective residents, and having no decision-making power in accepting residents. Women burned out more if they screened prospective residents or ran group meetings with residents. Significant relationships were also found between burnout and where time off was spent and support of friends, staff, and the organization. The author suggests that group home programs should differentially allocate tasks to men and women and should work with men on overly high expectations.
Die Schwebelaryngoskopie und Ihre Praktische Verwertung.
Authors: Gustav Killian
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase I/II Trial of Weekly Escalated Dose Bortezomib Combined with Lenalidomide and Dexamethasone in Patients in First Relapse or Primary Refractory Disease after First Line Therapy for Multiple Myeloma
Authors: Annemiek Broijl, Marie José Kersten, Wendim Ghidey Alemayehu, Mark-David Levin, Okke de Weerdt, Edo Vellenga, Ellen Meijer, Shulamiet Wittebol, Rosita Ghiraw-Visser, Marian Stevens-Kroef, Berna Beverloo, Gerard M.J. Bos, Pierre W. Wijermans, Henk Lokhorst, Pieter Sonneveld
Journal: Blood (2014)
Treatise on the Diseases of Women. For the use of Students and Practitioners
Authors: Alexander Johnstone Chalmers Skene, Alexander Johnston Chalmers Skene
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of staging and scoring systems in hepatocellular carcinoma (HCC): Lessons from U.S. regional analysis of the GIDEON registry.
Authors: Rebecca A. Miksad, Allen Lee Cohn, Anthony B. El-Khoueiry, Jean-Francois Geschwind, Pierre Michel Gholam, Alec Goldenberg, Parvez Mantry, Robert C. G. Martin, Brendan McGuire, Bilal Piperdi, Arun J. Sanyal, Joanne Imperial, Alan Paul Venook
Journal: Journal of Clinical Oncology (2014)

323 Background: Because HCC usually occurs in the presence of liver disease, patient (pt) evaluation and treatment are complex and require multidisciplinary care. Tumor staging and liver function scoring systems facilitate HCC research and treatment. However, specialists have varied training in these systems. We evaluated specialty-specific reporting of HCC-related staging/scoring data. Methods: GIDEON is a global, prospective, non-interventional study to evaluate sorafenib (SOR) in HCC under real-life practice conditions. Pts with unresectable HCC who were candidates for systemic therapy and for whom a decision was made to treat with SOR were eligible. Frequency of recorded Child-Pugh (CP); Barcelona Clinic Liver Cancer (BCLC); Cancer of the Liver Italian Program (CLIP); Tumor, Nodes, Metastasis (TNM); and calculated Model for End-stage Liver Disease (MELD) data were analyzed by physician specialty. Results are descriptive. Results: In the safety population (n=563), 299 pts (41%) were enrolled by medical oncology (MO), 228 (40%) by hepatology/gastroenterology (H/G), and 39 (5%) by other (23 by surgeons; 7 by interventional radiologists). 89% were treated by a multidisciplinary team. MO pts were twice as likely as H/G pts to be not evaluable (NE) for CP (table). Unknown international normalized ratio (INR) was the primary reason CP was NE. MO and H/G pts had similar % NE for BCLC stage. H/G pts were more likely to have ECOG performance status (PS) not recorded. MO pts were less likely to have CLIP or MELD data, while H/G pts were less likely to have TNM data. Portal vein thrombosis (PVT) and alpha-fetoprotein (AFP) were unknown in 17% overall. Conclusions: The elements of HCC staging systems represent factors that may influence patient management. Lack of complete data in up to 44% of pts, despite registry enrollment requiring data collection, suggests clinicians may be missing important information and the prevalence of clinicians using comprehensive HCC staging systems is variable. Clinical trial information: NCT00812175. [Table: see text]
Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study
Journal: BMJ (2006)

<h3>Abstract</h3> <b>Objective</b> To assess the accuracy of preoperative staging of rectal cancer with magnetic resonance imaging to predict surgical circumferential resection margins. <b>Design</b> Prospective observational study of rectal cancers treated by colorectal multidisciplinary teams between January 2002 and October 2003. <b>Setting</b> 11 colorectal units in four European countries. <b>Participants</b> 408 consecutive patients presenting with all stages of rectal cancer and undergoing magnetic resonance imaging before total mesorectal excision surgery and histopathological assessment of the surgical specimen. <b>Main outcome measures</b> Accuracy of magnetic resonance imaging in predicting a curative resection based on the histological yardstick of presence or absence of tumour at the margins of the specimen. <b>Results</b> 354 of the 408 patients had a clear circumferential resection margin (87%, 95% confidence interval 83% to 90%). Specificity for prediction of a clear margin by magnetic resonance imaging was 92% (327/354, 90% to 95%). High resolution scans were technically satisfactory in 93% (379/408). Surgical specimens were histopathologically graded as complete or moderate in 80% (328/408), and the median lymph node harvest was 12 (range 0-49). Magnetic resonance imaging predicted clear margins in 349 patients. At surgery 327 had clear margins (94%, 91% to 96%). <b>Conclusion</b> High resolution magnetic resonance imaging accurately predicts whether the surgical resection margins will be clear or affected by tumour. This technique can be reproduced accurately in multiple centres to predict curative resection and warns the multidisciplinary team of potential failure of surgery, thus enabling selection of patients for preoperative treatment.
Abstract P4-04-21: Host response to microbes found in the tumor microenvironment and healthy adjacent tissue
Authors: Marian Navarrete, Peter A Sieling, Delphine J Lee, Andrew W Chung
Journal: Cancer Research (2015)

Abstract Next generation sequencing methods have defined the bacterial microbiome in human breast milk and breast tissue, but the role of bacteria or their components in breast cancer has not been well defined. There is growing evidence in humans and animals that alterations of the gut microbiome may contribute to host susceptibility to cancer. However, the presence of bacteria at the site of the tumor microenvironment may also contribute to carcinogenesis (e.g. by promoting chronic inflammation) or immune surveillance (e.g. by stimulating antitumor pathways). Previously, we found that bacterial load in breast cancer tissue is inversely correlated to the progression of disease and that antimicrobial gene expression was comparatively higher in breast tissue from healthy subjects. Our investigation of the microbiome of breast tissue showed that overall microbiome signatures in breast cancer patients are similar when comparing their healthy adjacent tissue vs. the tumor tissue. However, our published preliminary studies did identify some differences in the abundance of specific bacteria between the two tissues. Here we investigated how those bacteria in healthy adjacent vs. tumor tissue may differentially stimulate cells found in breast tissue including breast ductal epithelium, adipocytes, and immune cells. Our preliminary data suggest that bacteria found in healthy adjacent vs. tumor tissue stimulate differential cytokine responses that may shape the local tumor microenvironment and beyond and may also contribute to local/regional immune surveillance. Citation Format: Marian Navarrete, Peter A Sieling, Delphine J Lee, Andrew W Chung. Host response to microbes found in the tumor microenvironment and healthy adjacent tissue [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-04-21.
Abstract 3155: Protective Effect of Endothelial Kruppel-like Transcription Factor- 2 Gene Transfer in the Monocrotaline Model of Pulmonary Hypertension
Authors: Alison A Dungey, Yupu Deng, Steffen-Sebastian Bolz, Duncan J Stewart
Journal: Circulation (2009)

RATIONALE: Pulmonary Hypertension (PH) is a result of endothelial damage and dysfunction. Kruppel-like factor-2 (KLF2) is a shear-responsive transcription factor thought to maintain endothelial ho...
Abstract 3734: Live Three-Dimensional Color-Flow Doppler Improves the Comprehensive Analysis of Mitral Regurgitant Jet
Authors: Thierry Le Tourneau, Marjorie Richardson, Anne-Sophie Polge, Sebastien Pouwels, Audrey Duchemin, Georges Fayad, Andre Vincentelli, Henri Warembourg, Christophe Bauters, Ghislaine Deklunder
Journal: Circulation (2006)
Le liquide céphalo-rachidien: Physiologie et exploration du système ventriculoméningé.
Authors: Marcel Riser
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3429: SIRT3 Blocks Agonist Mediated Cardiomyocyte Hypertrophy by Suppressing the ROS Mediated Ras Activation and the Downstream ERK and Akt/mTOR Pathways
Authors: Nagalingam Sundaresan, Vinodkumar Pillai, Senthilkumar Rajamohan, Sadhana Samant, Mahesh P Gupta
Journal: Circulation (2008)
Korean MERS virus is not a mutation, say experts
Authors: D. Sachan
Journal: BMJ (2015)

Korean scientists have said that the virus causing the severe outbreak of Middle East respiratory syndrome in their country has not undergone significant mutation.

MERS has killed 10 people so far in South Korea, and 122 cases of the disease have been confirmed. The first case was diagnosed on 20 May.1 South Korea is experiencing the biggest outbreak of the disease outside Saudi Arabia, where the first case of MERS was reported in 2012. Symptoms of MERS include fever, cough, and shortness of breath.

MERS is a type of coronavirus. The outbreak of severe acute respiratory …