tbuckley/cabot-search huggingface dataset:
In vitro and in vivo studies on the degradation of high-purity Mg (99.99wt.%) screw with femoral intracondylar fractured rabbit model
Authors: Pei Han, Pengfei Cheng, Shaoxiang Zhang, Changli Zhao, Jiahua Ni, Yuanzhuang Zhang, Wanrun Zhong, Peng Hou, Xiaonong Zhang, Yufeng Zheng, Yimin Chai
Journal: Biomaterials (2015)
Nutrition and Metabolism in Pregnancy: Mother and Fetus
Authors: Pedro Rosso
Journal: Annals of Internal Medicine (1991)

Discusses maternal-fetal exchange of nutrients indicating that the quantity of nutrients reaching the fetus reflects not only what the mother eats, but also her capacity to make the ingested nutrients available to the fetus. Includes chapters on physiological changes of pregnancy; maternal metabolism of energy substrates, amino acids, vitamins and minerals; fetal growth and nutritional needs; maternal-fetal exchange of nutrients; maternal caloric intake and fetal growth; fetal consequences of vitamin and mineral deficiencies; nutritional care during pregnancy; and nutritional care of gravidas with special problems
Isotopic Tracers in Biochemistry and Physiology
Authors: Jacob Sacks
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RESTRAINT OF CHILDREN IN CARS: EDUCATION IS NOT JUST LEGISLATION
Authors: A Bodenham, R J Newman
Journal: BMJ (1991)

This brief article discusses the need for greater education about the correct way to use child seat belts and other child restraint systems. Following the introduction of legislation making it mandatory that children be restrained in the rear seats of cars when suitable equipment is fitted, there have been an increasing number of reports of injuries, particuarly to the spine, to children thus restrained in cars involved in road traffic accidents. Use of restraints in the United Kingdom is following the same pattern of widespread misuse identified previously in the United States and Sweden. Errors in restraint fall into four broad categories: (a) the child is placed in a restraint that is not designed to give protection in a crash; (b) the child is placed in a restraint that is not designed for his or her size or weight; (c) the child restraint is not properly anchored to the car; and (d) the restraint is not correctly applied to the child. The problem of selecting the 'best' restraint for any particular child is compounded by the facts that: (a) in practice such restraints may need to be used by several children of differing heights and weights; and (b) current devices are not always easy to fit, and adjustments to fit an individual child is often difficult and unnecessarily time consuming. The legislation in the United Kingdom offers only guidelines but useful interpretation is provided by the British Standards Institution and the Child Accident Prevention Trust. It is recommended that: (a) car manufacturers should recommend certain restraints as suitable for their vehicles and include instructions in the car handbook; (b) manufacturers of restraints should be able to provide accurate and detailed advice about their products; and (c) sound research should be carried out to determine the types of restraint best suited to children of different sizes and weights.
Relationship between sex hormones and cognition in men with and without prostate cancer
Authors: S. M. H. Alibhai, S. Gogov, I. Tannock, I. Chemerynsky, A. Park, M. Homer, N. E. Fleshner, G. Naglie, M. D. Krahn, S. Duff Canning
Journal: Journal of Clinical Oncology (2005)

4619 Background: Several small reports have suggested that androgen deprivation therapy (ADT)-induced hypogonadism may be associated with neuropsychological side effects in men with prostate cancer, although results are inconsistent. Studies in other settings have identified several cognitive domains that may be affected by circulating sex hormone levels. Methods: Men age 50 or older with non-metastatic prostate cancer who were fluent in English were enrolled and matched on age and education to controls without prostate cancer. No man had started ADT at the time of testing. Five cognitive domains were examined using a comprehensive neuropsychological battery - attention; language; visuo-spatial function (2 tests); memory (2 tests); executive function (2 tests). Sex hormones included total and bioavailable testosterone, and estradiol. Relationships between sex hormones and each cognitive test were examined using Pearson’s correlation. Multivariable linear regression was used to control for age and education. Results: 52 patients (30 with prostate cancer, 22 controls) have been enrolled to date (mean age 69, range 57–87; mean education 16 years). 50% had biochemical evidence of hypogonadism. Age was negatively correlated with performance on both memory tests (r=0.48–0.50, p<0.001) and one of two executive function tasks (r=0.44, p<0.005) Education was positive correlated with performance on one of two visuo-spatial tasks (r=0.52, p<0.001). Bioavailable testosterone was positively correlated with one of two memory tasks (r=0.38, p=0.01) and weakly with language (r=0.28, p=0.07). Correlations between other sex hormones and cognitive tasks were not statistically significant (p>0.05). After adjusting for age and educational level, relationships between sex hormones and cognitive tasks were no longer statistically significant but confidence limits were relatively wide. Conclusions: Preliminary data suggest testosterone may have some influence on memory but does not affect four of five other cognitive domains. A larger sample and longitudinal data on patients initiating ADT will be important to determine if cognitive function declines with ADT use. No significant financial relationships to disclose.
Diseases of the Heart: Their Diagnosis, Prognosis, and Treatment by Modern Methods, with a Chapter on the Electro-Cardiograph.
Authors: Frederick William Price
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A multicenter phase 2 study of irinotecan (CPT-11) and doxifluridine (5’-DFUR), an intermediate form of capecitabine, for metastatic colorectal cancer (MCRC)
Authors: M. Ikenaga, T. Kato, H. Mishima, M. Fukunaga, K. Murata, S. Tominaga, T. Kano, S. Morita, M. Sekimoto, J. Sakamoto, M. Monden
Journal: Journal of Clinical Oncology (2005)

3698
Abstract 9191: MicroRNA-150 is Essential in the Regulation of Blood Pressure
Authors: Zhong Zuo, Han Lei, Zhongjie Sun
Journal: Circulation (2011)

Background &amp; Hypothesis. Micro RNAs are small noncoding RNAs that regulate protein expression at the post-transcriptional level. The purpose of this study was to determine if microRNA-150 (miR-150) plays a role in the regulation of blood pressure (BP). Methods &amp; Results. We found that knockout of miR-150 resulted in a significant increase in systolic, diastolic and mean BP in mice. Vascular relaxing responses to acetylcholine were decreased significantly in miR-150 knockout (miR150-KO) mice, suggesting impaired endothelial function. Therefore, miR-150 is essential in the maintenance of normal BP and endothelial function. MiR150-KO was accompanied by a significant increase in NADPH oxidase activity and superoxide production in aortas and kidneys. MiR150-KO mice demonstrated vascular and renal remodeling. Interestingly, miR150-KO significantly increased Cyp11β2 protein expression in adrenal cortex, suggesting that miR-150 is a negative regulator of Cyp11β2. Plasma level of aldosterone was elevated in the miR150-KO mice. It was noted that daily treatment with aldosterone receptor blockade eplerenone (EPL) effectively reversed hypertension, endothelial dysfunction, increases in NADPH oxidase activity and superoxide production, and vascular and renal damage in miR150-KO mice. Conclusions. These results suggest that miR150-KO-inudced hypertension may be mediated by the upregulation of Cyp11β2 expression which led to increased biosynthesis of aldosterone. It is concluded that miR-150 is a critical regulator of Cyp11β2 in the control of BP. MiR-150 may be a novel therapeutic target for hypertension. (Supported by NIH R01 HL105362).
De la psychose paranoïaque dans ses rapports avec la personnalité
Authors: Jacques Lacan
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
System der Neurose.
Authors: Emil Kugler
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 11159: Acute Coronary Syndrome in Adults with a History of Kawasaki Disease: A Japanese Nationwide Survey
Authors: Yoshihide Mitani, Etsuko Tsuda, Hitoshi Kato, Syunichi Ogawa, Yosikazu Nakamura, Kei Takahashi, Mamoru Ayusawa, Touru Kobayashi, Fukiko Ichida, Masaki Matsushima, Masahiro Kamata, Takashi Higaki, Kenji Suda, Hiroyuki Ohashi, Hiroyoshi Yokoi, Kenji Hamaoka
Journal: Circulation (2011)

Background: A risk for acute coronary events in adults with a history of Kawasaki disease (KD) is still speculative. Methods: We conducted a nationwide questionnaire survey to test the hypothesis t...
Association of serum level of YKL-40 in patients with squamous cell carcinoma of the head and neck with survival
Authors: A. Roslind, J. S. Johansen, I. J. Christensen, J. Bentzen, D. L. Nielsen, P. A. Price, E. Andersen
Journal: Journal of Clinical Oncology (2006)

5551 Background: High serum YKL-40 is associated with poor prognosis in breast-, colorectal-, ovarian-, prostate-, small cell lung carcinoma and malignant melanoma. YKL-40 is secreted by cancer cells, macrophages and neutrophils. Its function in cancer is unknown. It may be a growth factor, play a role in angiogenesis or protect against apoptosis. The aim was to examine serum YKL-40 in patients with squamous cell carcinoma of the head and neck (SCCHN). Methods: YKL-40 was determined by ELISA (Quidel, Santa Clara, CA) in serum samples from 138 patients with SCCHN (median age 60, range 44–92 years) before surgery and/or fractionated radiotherapy (total dose of 60–68 Gy, 2-Gy fractions). 42 patients had stage 1, 28 stage 2, 22 stage 3, and 46 stage 4 disease. The median follow-up time was 4.0 years (range 15 days–8.5 years). 91 patients had died. Results: Serum YKL-40 was increased (p &lt; 0.001) in patients with SCCHN (median 120 μg/l, range 25–1848 μg/l) compared to healthy controls (43 μg/l, 20–184 μg/l, n = 245). Serum YKL-40 was elevated in 52% of the patients. Patients with stage 1 disease had lower, but non-significant, serum YKL-40 compared to patients with stage 2–4 disease (median 113 μg/l, range 25–1000 μg/l vs. 139 μg/l, 29–1848 μg/l, p = 0.06). Patients with high serum YKL-40 had significantly shorter survival than patients with normal serum YKL-40 (33 months vs. 74 months, p = 0.01 logrank test). Univariate analysis of serum YKL-40 (log transformed and treated as a continuous covariate) showed significant association with overall survival after start of therapy (HR = 1.4, 95% CI: 1.2–1.7, p = 0.0004). Multivariate Cox analysis including age, stage and serum YKL-40 (log transformed and treated as a continuous variable) showed that stage (stage 3–4 vs. stage 1–2, HR = 3.0, 95% CI: 1.9–4.6, p &lt; 0.0001) and serum YKL-40 (HR = 1.5, 95% CI: 1.2–1.8, p = 0.0003) were independent prognostic variables of overall survival. Conclusions: Serum YKL-40 is a prognostic biomarker of overall survival in SCCHN patients. No significant financial relationships to disclose.
Particulate Air Pollution Exposure and Expression of Viral and Human MicroRNAs in Blood: The Beijing Truck Driver Air Pollution Study
Authors: Lifang Hou, Jitendra Barupal, Wei Zhang, Yinan Zheng, Lei Liu, Xiao Zhang, Chang Dou, John P. McCracken, Anaité Díaz, Valeria Motta, Marco Sanchez-Guerra, Katherine Rose Wolf, Pier Alberto Bertazzi, Joel D. Schwartz, Sheng Wang, Andrea A. Baccarelli
Journal: Environmental Health Perspectives (2015)

MicroRNAs (miRNAs) are post-transcriptional gene suppressors and potential mediators of environmental effects. In addition to human miRNAs, viral miRNAs expressed from latent viral sequences are detectable in human cells.In a highly exposed population in Beijing, China, we evaluated the associations of particulate air pollution exposure on blood miRNA profiles.The Beijing Truck Driver Air Pollution Study (BTDAS) included 60 truck drivers and 60 office workers. We investigated associations of short-term air pollution exposure, using measures of personal PM2.5 (particulate matter ≤ 2.5 μm) and elemental carbon (EC), and ambient PM10 (≤ 10 μm), with blood NanoString nCounter miRNA profiles at two exams separated by 1-2 weeks.No miRNA was significantly associated with personal PM2.5 at a false discovery rate (FDR) of 20%. Short-term ambient PM10 was associated with the expression of 12 miRNAs in office workers only (FDR < 20%). Short-term EC was associated with differential expression of 46 human and 7 viral miRNAs, the latter including 3 and 4 viral miRNAs in office workers and truck drivers, respectively. EC-associated miRNAs differed between office workers and truck drivers with significant effect modification by occupational group. Functional interaction network analysis suggested enriched cellular proliferation/differentiation pathways in truck drivers and proinflammation pathways in office workers.Short-term EC exposure was associated with the expression of human and viral miRNAs that may influence immune responses and other biological pathways. Associations between EC exposure and viral miRNA expression suggest that latent viral miRNAs are potential mediators of air pollution-associated health effects. PM2.5/PM10 exposures showed no consistent relationships with miRNA expression.
Nutrition in Health and Disease.
Authors: Gary Price Todd
Journal: JAMA (1963)

Dr. Todd demonstrates first that our diet is not only deficient and why, but that it cannot be made adequate without supplementation. He explains the concept of free radical pathology in simple, understandable terms, and shows how elevated blood cholesterol is the result of the body's attempt to neutralize the destructive free radicals. Cholesterol is a friend, rather than an enemy, and selected vitamins and minerals effectively neutralize free radicals and thus allow cholesterol levels to drop. There is no reason, Dr. Todd concludes, that our normal life span shouldn't be about 120 years. Concisely written, this book is aimed squarely at the people who are increasingly concerned about their health, and accept responsibility for their own destiny. It is without a doubt the best book on health and nutrition ever written for a growing health-conscious population.
Diagnostic Value of Secretory Function in Gastric Disease: Various Methods Studied and Compared
Authors: Ernest H. Gaither
Journal: Annals of Internal Medicine (1932)

Article1 February 1932Diagnostic Value of Secretory Function in Gastric Disease: Various Methods Studied and ComparedERNEST H. GAITHER, M.D., F.A.C.P.ERNEST H. GAITHER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-8-992 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past few years, renewed and continued interest has been manifested by numerous investigators in the domain of gastric secretion, and the test which has apparently met with almost universal favor has been that in which histamine, subcutaneously administered, has been used as the stimulator of gastric gland activity.A careful survey of the current literature on this subject reveals the interesting fact that practically all observers agree as to the direct action of this drug upon the gastric glands, or upon a mechanism which has intimately to do with their secretion; innumerable tests of acidity have satisfied many... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Md.*Read before the American Gastro-Enterological Association, Atlantic City, May 5, 1931.†From the Gastro-Intestinal Clinic of Johns Hopkins Hospital, Baltimore. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySpontaneous variations in gastric secretion in response to histamine stimulationHistory and development of gastric analysis procedure (third installment) 1 February 1932Volume 5, Issue 8Page: 992-996KeywordsDrugsGastric mucosaGastroenterology and hepatologyHistamineHospitals Issue Published: 1 February 1932 PDF DownloadLoading ...
A randomized phase II study of pemetrexed-carboplatin and gemcitabine-vinorelbine in patients with anthracycline- and taxane-pretreated advanced breast cancer.
Authors: D. Amadori, I. La Torre, E. M. Carrasco, S. Roesel, R. Labianca, V. Moreau-Donnet, D. Desaiah, M. Martin
Journal: Journal of Clinical Oncology (2011)

1051 Background:Pemetrexed (Pem) and platinum compounds have single-agent activity in advanced breast cancer (BC). Anthracyclines (Atc) and taxanes are used to treat BC patients (pts), with limited options available after their failure. Pem-carboplatin (Pem-Carb) combination was active and well tolerated in a phase II study in first-line BC pts. It is worth exploring Pem-Carb combination in pts pretreated with Atc and taxanes. Methods:In this collaborative study with GEICAM, women pts with advanced BC previously treated with Atc and taxanes, with ≥1 measurable lesion by RECIST, and had received ≥1 dose of study drug. Pts were stratified by line of treatment (1st, 2nd), visceral disease (yes/no), and ECOG PS (0−1 vs 2) and randomized 1:1 to Pem-Carb (Pem, 600 mg/m2, D1 iv q21; Carb, AUC 5, D1 iv q21, vitamin B12 and folic acid supplementation) or gemcitabine-vinorelbine (Gem, 1200 mg/m2 D1, D8 iv q21; Vin, 30 mg/m2 D1, D8 iv q 21). Tx was continued until progression. The primary endpoint was objective response rate (RR). Secondary endpoints were duration of response (DOR), time to response (TTR), time to progressive disease (TTP), and safety. A two-stage design was employed independently for each arm which should contain 68 evaluable pts and at least 21 pts to reject H0 (RR≤22%), respectively. Results: Of 135 (Pem-Carb, 69; Gem-Vin, 66) randomized pts, 125 (Pem-Carb, 64; Gem-Vin, 61) were qualified for tumor response analysis. Baseline characteristics were similar in both arms, with a median age of 52 years. Median number of cycles delivered in both arms: 6.0 (range 1−21); relative dose intensity, mean % (SD): Pem, 88.5 (12.7); Carb, 86.1 (13.8); Vin, 68.1 (14.4); Gem, 68.4 (14.4). Efficacy findings—RR, 95% CI: Pem-Carb, 26.6 (16.3−39.1), Gem-Vin, 29.5 (18.5−42.6); median DOR, months: Pem-Carb, 7.7, Gem-Vin, 7.5; median TTP, months: Pem-Carb, 5.1, Gem-Vin, 5.6; overall median TTR, 1.8 months. Most common (≥5% of pts) study drug–related hematological adverse events: anemia, neutropenia, and thrombocytopenia. Conclusions: In this heavily pre-treated population, both arms showed moderate activity as predefined RR was not reached. Both regimens were well tolerated.