tbuckley/cabot-search huggingface dataset:
Understanding the relationship between obesity and in-hospital outcomes in gastric cancer patients : A nationwide analysis.
Authors: Nataly Ortega Yaguachi, Saad Javaid, Kelly Frasier, Vivian Li, Julia Vinagolu-Baur, Evadne Rodriguez, Olivia Del Castillo, Raquel Batista, Kenlee Jonas, Laura Palma
Journal: Journal of Clinical Oncology (2024)

e16050 Background: Gastric cancer is the fifth most common form of cancer and the third leading cause of cancer-related deaths worldwide. Obesity has been identified as a significant risk factor for gastric cancer, associated with increased incidence and heightened complications in hospitalized patients. Our analysis comprehensively evaluates obesity's impact on hospital-admitted gastric cancer patients. Methods: Using the National Inpatient Sample (NIS) 2020, we identified gastric cancer patients with regional and advanced metastatic disease, and they were stratified into patients with and without obesity. The primary outcome was mortality, and secondary outcomes included length of stay, the total cost of hospitalization, and other in-hospital adverse outcomes. Multivariate logistic regression analysis was used to calculate the outcomes after adjusting for confounding variables. Results: A total of 17560 patients were hospitalized with gastric cancer, among which 1720(9.8%) had the concurrent diagnosis of Obesity. The mean age of patients with and without Obesity was 63 (+/- 13.88) and 66 (+/- 12.93),p&lt;0.001 respectively. The obese category had the greater percentage of male patients as compared to females (58.14% vs 44.85% respectively, p&lt;0.001). After adjusting for confounding variables, Obesity was not considered as an independent predictor of mortality in patients with gastric cancer (OR=1.06(0.59-1.92); p=0.90). However, patients with Obesity had prolonged length of stay (+ 1.52 days(1.49-2.26); p=0.004) and total cost of hospitalization (+ $30977(12320-49633); p=0.001). Similarly, obese patients had an increased likelihood of Acute kidney injury (OR=1.47(1.09-1.96); p=0.01), ICU admission (OR=2.01(1.30-3.09); p=0.002), invasive (OR=2.14(1.29-3.54); p=0.003) Noninvasive mechanical ventilation (OR=5.36(2.17-13.14); p&lt;0.001) and Heart failure (OR=1.68(1.09-2.57); p=0.02). No difference was noted in the risk of cardiac arrest (OR=1.26(0.28-5.68); p=0.76), and sepsis(OR=1.76(0.99-3.13); p=0.05). Conclusions: Obesity in patients with gastric cancer is not an independent predictor of mortality but is associated with increased length of stay, the total cost of hospitalization, increased risk of mechanical ventilation, and ICU admissions. Management of obesity can prove crucial in averting a wide range of potential health complications and significantly enhancing the overall quality of life in gastric cancer patients. [Table: see text]
Targeted delivery of anti-miRNA21 sensitizes PD-L1<sup>high</sup> tumor to immunotherapy by promoting immunogenic cell death
Authors: Eun Hye Kim, Jiwoong Choi, Hochung Jang, Yelee Kim, Jong Won Lee, Youngri Ryu, Jiwon Choi, Yeonho Choi, Sung-Gil Chi, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim
Journal: Theranostics (2024)

Growing evidence has demonstrated that miRNA-21 (miR-21) upregulation is closely associated with tumor pathogenesis. However, the mechanisms by which miR-21 inhibition modulates the immunosuppressive tumor microenvironment (TME) and improves tumor sensitivity to immune checkpoint blockade therapies remain largely unexplored. In this study, we demonstrate the precise delivery of anti-miR-21 using a PD-L1-targeting peptide conjugate (P21) to the PD-L1
Highlighting fibroblast plasticity in lung fibrosis: the WI-38 cell line as a model for investigating the myofibroblast and lipofibroblast switch
Authors: Esmeralda Vásquez-Pacheco, Manuela Marega, Arun Lingampally, Julien Fassy, Marin Truchi, Kerstin Goth, Lisa Trygub, Sara Taghizadeh, Marek Bartkuhn, Ioannis Alexopoulos, Ying Dong, Kevin Lebrigand, Andreas Gunther, Chengshui Chen, JinSan Zhang, Cho-Ming Chao, Denise Al Alam, Elie El Agha, Bernard Mari, Saverio Bellusci, Stefano Rivetti
Journal: Theranostics (2024)

Myofibroblasts (MYFs) are generally considered the principal culprits in excessive extracellular matrix deposition and scar formation in the pathogenesis of lung fibrosis. Lipofibroblasts (LIFs), on the other hand, are defined by their lipid-storing capacity and are predominantly found in the alveolar regions of the lung. They have been proposed to play a protective role in lung fibrosis. We previously reported that a LIF to MYF reversible differentiation switch occurred during fibrosis formation and resolution. In this study, we tested whether WI-38 cells, a human embryonic lung fibroblast cell line, could be used to study fibroblast differentiation towards the LIF or MYF phenotype and whether this could be relevant for idiopathic pulmonary fibrosis (IPF).
A novel selenium analog of HDACi-based twin drug induces apoptosis and cell cycle arrest via CDC25A to improve prostate cancer therapy
Authors: Zhiyong Shi, Miaomiao Liu, Xiaowen Zhang, Jingyang Wang, Junwei Zhang, Zeyan Peng, Li Meng, Ruijing Wang, Lihong Guo, Qiang Zhang, Jing Li, Liang Yang, Jie Liu, Yang Xu, Jie Yan, Jianlin Cui, Shan Ren, Yang Gao, Yanming Wang, Zhi Qi
Journal: Theranostics (2024)

Cancer therapy has moved from single agents to more mechanism-based targeted approaches. In recent years, the combination of HDAC inhibitors and other anticancer chemicals has produced exciting progress in cancer treatment. Herein, we developed a novel prodrug via the ligation of dichloroacetate to selenium-containing potent HDAC inhibitors. The effect and mechanism of this compound in the treatment of prostate cancer were also studied.
GPAT3 is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma
Authors: Yu Zhou, Huakan Zhao, Ran Ren, Mingyue Zhou, Jiangang Zhang, Zhijuan Wu, Yu Chen, Juan Lei, Yang Chen, Ying Yu, Yongsheng Li
Journal: Theranostics (2024)

Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC), but acquired resistance during the treatment greatly limits its clinical efficiency. Lipid metabolic disorder plays an important role in hepatocarcinogenesis. However, whether and how lipid metabolic reprogramming regulates sorafenib resistance of HCC cells remains vague.
Incidence and Prediction of Anoxic Brain Injury in Concomitant Cardiac Arrest and Cardiogenic Shock
Authors: Lisa Besch, Jessica Weimann, Jacob Jentzer, Benedikt Beer, Angela Dettling, Jonas Sundermeyer, Paulus Kirchhof, Stefan Blankenberg, Dirk Westermann, Benedikt Schrage
Journal: JACC Heart Failure (2024)
Opto-seq reveals input-specific immediate-early gene induction in ventral tegmental area cell types
Authors: Rhiana C. Simon, Mary C. Loveless, Joshua X. Yee, Brandon Goh, Su G. Cho, Zainab Nasir, Koichi Hashikawa, Garret D. Stuber, Larry S. Zweifel, Marta E. Soden
Journal: Neuron (2024)
Enhancing precision: A predictive model for <sup>177</sup>Lu-DOTATATE treatment response in neuroendocrine tumors using quantitative <sup>68</sup>Ga-DOTATATE PET and clinicopathological biomarkers
Authors: Azadeh Akhavanallaf, Sonal Joshi, Arathi Mohan, Francis P Worden, John C Krauss, Habib Zaidi, Kirk Frey, Krithika Suresh, Yuni K Dewaraja, Ka Kit Wong
Journal: Theranostics (2024)

This study aims to elucidate the role of quantitative SSTR-PET metrics and clinicopathological biomarkers in the progression-free survival (PFS) and overall survival (OS) of neuroendocrine tumors (NETs) treated with peptide receptor radionuclide therapy (PRRT).
Effectiveness and cost-effectiveness of an individualised, progressive walking and education intervention for the prevention of low back pain recurrence in Australia (WalkBack): a randomised controlled trial
Authors: Natasha C Pocovi, Chung-Wei Christine Lin, Simon D French, Petra L Graham, Johanna M van Dongen, Jane Latimer, Dafna Merom, Anne Tiedemann, Christopher G Maher, Ornella Clavisi, Shuk Yin Kate Tong, Mark J Hancock
Journal: The Lancet (2024)
Automated cooling tower detection through deep learning for Legionnaires’ disease outbreak investigations: a model development and validation study
Authors: Karen K Wong, Thaddeus Segura, Gunnar Mein, Jia Lu, Elizabeth J Hannapel, Jasen M Kunz, Troy Ritter, Jessica C Smith, Alberto Todeschini, Fred Nugen, Chris Edens
Journal: The Lancet Digital Health (2024)

Cooling towers containing Legionella spp are a high-risk source of Legionnaires' disease outbreaks. Manually locating cooling towers from aerial imagery during outbreak investigations requires expertise, is labour intensive, and can be prone to errors. We aimed to train a deep learning computer vision model to automatically detect cooling towers that are aerially visible.
Proteomic prediction of diverse incident diseases: a machine learning-guided biomarker discovery study using data from a prospective cohort study
Authors: Julia Carrasco-Zanini, Maik Pietzner, Mine Koprulu, Eleanor Wheeler, Nicola D Kerrison, Nicholas J Wareham, Claudia Langenberg
Journal: The Lancet Digital Health (2024)

Broad-capture proteomic technologies have the potential to improve disease prediction, enabling targeted prevention and management, but studies have so far been limited to very few selected diseases and have not evaluated predictive performance across multiple conditions. We aimed to evaluate the potential of serum proteins to improve risk prediction over and above health-derived information and polygenic risk scores across a diverse set of 24 outcomes.
Disparities in the prevalence of acute pulmonary embolism in patients with ovarian cancer: A nationwide analysis.
Authors: Evadne Rodriguez, Saad Javaid, Kelly Frasier, Vivian Li, Julia Vinagolu-Baur, Nataly Ortega Yaguachi, Olivia Del Castillo, Raquel Batista, Kenlee Jonas, Laura Palma
Journal: Journal of Clinical Oncology (2024)

e17560 Background: Ovarian cancer is the leading cause of death among gynecological cancers. It is highly thrombogenic and is associated with increased venous thromboembolism events. We conducted a retrospective analysis to study the prevalence and disparities in the association of Acute Pulmonary embolism(PE) with ovarian cancer. Methods: National Inpatient Sample (2017-2020) was used to identify the patients with primary diagnosis of Acute PE and was stratified into those with and without concurrent diagnosis of Ovarian cancer ( regional and advanced metastatic disease). Basic demographic variables were analyzed to identify disparities in the prevalence of Acute PE among ovarian cancer patients.Multivariate logistic regression analysis was conducted to examine the association between Acute PE and Ovarian cancer. Results: A total of 651435 patients were hospitalized with a primary diagnosis of Acute PE, and 2980 (0.46%) had a secondary diagnosis of Ovarian cancer. The ovarian cancer group had a greater percentage of white (73.4% vs.71.93%), Hispanics (7.98% vs. 6.04%), and fewer Black patients (15.78% vs. 19.86), p=0.021. Compared to the white, Black population with ovarian cancer (OR=0.77(0.6-0.9); p=0.04) had a decreased likelihood of developing Acute PE without any difference noted in the Hispanics (OR=1.13 (0.81-1.58); p=0.44) and other races (OR=1.11 (0.67-1.83); p=0.67). Patients in the high income groups were more likely to be admitted due to acute PE ($65,000-$85,999: OR=1.35 (1.05-1.73), p=0.018; &gt;$86,000: OR=1.24 (1.14-1.62), p=0.01). A greater percentage of patients with ovarian cancer had private insurance (35.2% vs. 28.91%), while a greater percentage of patients without ovarian cancer had Medicare (54.38% vs. 50.34%) and Medicaid (11.9% vs. 12.5%), p=0.003. Patients with private insurance were more likely to be admitted due to acute PE (OR=1.73(1.36-2.22); p&lt;0.001). Patients with a Charlson comorbidity index of 3 or more had higher odds of Acute PE (OR=1.3(1.12-3.4); p=0.02). A greater percentage of Acute PE patients with ovarian cancer were admitted to large (54.03% vs. 47.86%; p=0.014), urban (95.3% vs. 90.35%; p&lt;0.001), and teaching hospitals (79.87% vs. 69.15%; p&lt;0.001). Teaching hospitals had higher odds of admissions due to acute PE in ovarian cancer patients (OR=1.37(1.07-1.75); p=0.01). On multivariate regression analysis, Ovarian cancer patients had higher odds of Acute PE (OR=1.88 (1.73-2.05); p&lt;0.001). Conclusions: Ovarian cancer patients with Black race and private insurance showed a significantly increased likelihood of admissions due to acute pulmonary embolism. Additionally, urban and teaching hospitals demonstrated higher odds of encountering cases of acute pulmonary embolism. Further prospective studies are necessary to validate the findings presented in our study.
Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies
Authors: Jiayao Chen, Zhuowen Hao, Hanke Li, Jianping Wang, Tianhong Chen, Ying Wang, Guang Shi, Junwu Wang, Zepu Wang, Zheyuan Zhang, Jingfeng Li
Journal: Theranostics (2024)

Osteoporosis is a systemic skeletal disease caused by an imbalance between bone resorption and formation. Current treatments primarily involve systemic medication and hormone therapy. However, these systemic treatments lack directionality and are often ineffective for locally severe osteoporosis, with the potential for complex adverse reactions. Consequently, treatment strategies using bioactive materials or external interventions have emerged as the most promising approaches. This review proposes twelve microenvironmental treatment targets for osteoporosis-related pathological changes, including local accumulation of inflammatory factors and reactive oxygen species (ROS), imbalance of mitochondrial dynamics, insulin resistance, disruption of bone cell autophagy, imbalance of bone cell apoptosis, changes in neural secretions, aging of bone cells, increased local bone tissue vascular destruction, and decreased regeneration. Additionally, this review examines the current research status of effective or potential biophysical and biochemical stimuli based on these microenvironmental treatment targets and summarizes the advantages and optimal parameters of different bioengineering stimuli to support preclinical and clinical research on osteoporosis treatment and bone regeneration. Finally, the review addresses ongoing challenges and future research prospects.
A Machine Learning Algorithm Avoids Unnecessary Paracentesis for Exclusion of SBP in Cirrhosis in Resource-limited Settings
Authors: Scott Silvey, Nilang Patel, Jinze Liu, Asiya Tafader, Mahum Nadeem, Galvin Dhaliwal, Jacqueline G. O’Leary, Heather Patton, Timothy R. Morgan, Shari Rogal, Jasmohan S. Bajaj
Journal: Clinical Gastroenterology and Hepatology (2024)
Deciphering m<sup>6</sup>A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy
Authors: Jiawen Li, Li Wei, Kaifeng Hu, Yunxiang He, Guidong Gong, Qisong Liu, Yue Zhang, Kaiyu Zhou, Junling Guo, Yimin Hua, Jun Tang, Yifei Li
Journal: Theranostics (2024)

Device implantation frequently triggers cardiac remodeling and fibrosis, with monocyte-driven inflammatory responses precipitating arrhythmias. This study investigates the role of m
Sleep deprivation causes gut dysbiosis impacting on systemic metabolomics leading to premature ovarian insufficiency in adolescent mice
Authors: Jiamao Yan, Xiaoyuan Zhang, Kexin Zhu, Mubin Yu, Qingchun Liu, Massimo De Felici, Teng Zhang, Junjie Wang, Wei Shen
Journal: Theranostics (2024)

Currently, there are occasional reports of health problems caused by sleep deprivation (SD). However, to date, there remains a lack of in-depth research regarding the effects of SD on the growth and development of oocytes in females. The present work aimed to investigate whether SD influences ovarian folliculogenesis in adolescent female mice.
Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria
Authors: Kelly A. Hagadorn, Mary E. Peterson, Hemanta Kole, Bethany Scott, Jeff Skinner, Ababacar Diouf, Eizo Takashima, Aissata Ongoiba, Safiatou Doumbo, Didier Doumtabe, Shanping Li, Padmapriya Sekar, Mei Yan, Chengsong Zhu, Hikaru Nagaoka, Bernard N. Kanoi, Quan-Zhen Li, Carole Long, Eric O. Long, Kassoum Kayentao, Scott A. Jenks, Ignacio Sanz, Takafumi Tsuboi, Boubacar Traore, Silvia Bolland, Kazutoyo Miura, Peter D. Crompton, Christine S. Hopp
Journal: Immunity (2024)
Metronomic chemotherapy in cancer treatment: new wine in an old bottle
Authors: Huai-Liang Wu, Han-Xing Zhou, Li-Min Chen, Shu-Sen Wang
Journal: Theranostics (2024)

Over the past two decades, metronomic chemotherapy has gained considerable attention and has demonstrated remarkable success in the treatment of cancer. Through chronic administration and low-dose regimens, metronomic chemotherapy is associated with fewer adverse events but still effectively induces disease control. The identification of its antiangiogenic properties, direct impact on cancer cells, immunomodulatory effects on the tumour microenvironment, and metabolic reprogramming ability has established the intrinsic multitargeted nature of this therapeutic approach. Recently, the utilization of metronomic chemotherapy has evolved from salvage treatment for metastatic disease to adjuvant maintenance therapy for high-risk cancer patients, which has been prompted by the success of several substantial phase III trials. In this review, we delve into the mechanisms underlying the antitumour effects of metronomic chemotherapy and provide insights into potential combinations with other therapies for the treatment of various malignancies. Additionally, we discuss health-economic advantages and candidates for the utilization of this treatment option.
Caspase-mediated AURKA cleavage at Asp<sup>132</sup> is essential for paclitaxel to elicit cell apoptosis
Authors: Xiaoting Chen, Shujuan Du, Yulin Zhang, Ke Peng, Lina Liu, Ting Wang, Hao Zhang, Shen Cai, Caixia Zhu, Youhai Li, Wen Tuo, Yuyan Wang, Fang Wei, Qiliang Cai
Journal: Theranostics (2024)

Aurora kinase A (AURKA) is a potent oncogene that is often aberrantly expressed during tumorigenesis, and is associated with chemo-resistance in various malignancies. However, the role of AURKA in chemo-resistance remains largely elusive.
Environment-responsive dendrobium polysaccharide hydrogel embedding manganese microsphere as a post-operative adjuvant to boost cascaded immune cycle against melanoma
Authors: Nan Gao, Yiran Huang, Shisuo Jing, Meng Zhang, Ergang Liu, Lu Qiu, Jing Huang, Bahtiyor Muhitdinov, Yongzhuo Huang
Journal: Theranostics (2024)

Surgical resection is a primary treatment for solid tumors, but high rates of tumor recurrence and metastasis post-surgery present significant challenges. Manganese (Mn
A mussel-inspired, antibacterial, antioxidant, injectable composite hydrogel for the sustain delivery of salvianolic acid B for the treatment of frozen shoulder
Authors: Yan Yan, Xinhao Li, Chen Chen, Dedong Cui, Zhuo Wang, Ming Li, Yi Long, Jinming Zhang, Cheng Li, Zhiling Wang, Chuanhai Zhou, Zeyu Yao, Dan Wang, Jingyi Hou, Rui Yang
Journal: Bioactive Materials (2024)
A smart hypochlorous acid fluorescent probe enabling Ibuprofen-release for osteoarthritis theranostics
Authors: Zhenni Lu, Peng Wei, Hongying Peng, Libo Jiang, Peiyi Wu, Tao Yi
Journal: Theranostics (2024)

Osteoarthritis (OA) standing as the most prevalent form of arthritis, closely associates with heightened levels of reactive oxygen species, particularly hypochlorous acid (HOCl). Although there are numerous probes available for detecting HOCl in the OA region, probes with dual functions of diagnostic and therapeutic capabilities are still significantly lacking. While this type of probe can reduce the time gap between diagnosis and treatment, which is clinically needed.
Extracellular vesicles from apoptotic BMSCs ameliorate osteoporosis via transporting regenerative signals
Authors: Maojiao Li, Qi Tang, Chengcheng Liao, Zhuo Wang, Siyuan Zhang, Qingqing Liang, Cheng Liang, Xiaodong Liu, Jingyi Zhang, Weidong Tian, Li Liao
Journal: Theranostics (2024)

Mesenchymal stromal cells (MSCs) are considered a promising resource for cell therapy, exhibiting efficacy in ameliorating diverse bone diseases. However, most MSCs undergo apoptosis shortly after transplantation and produce apoptotic extracellular vesicles (ApoEVs). This study aims to clarify the potential role of ApoEVs from apoptotic MSCs in ameliorating osteoporosis and molecular mechanism.
Trop2-targeted therapies in solid tumors: advances and future directions
Authors: Xinlin Liu, Leina Ma, Jiyixuan Li, Li Sun, Ying Yang, Ting Liu, Dongming Xing, Saisai Yan, Miao Zhang
Journal: Theranostics (2024)

Trophoblast cell surface antigen 2 (Trop2) is overexpressed in a range of solid tumors and participants in multiple oncogenic signaling pathways, making it an attractive therapeutic target. In the past decade, the rapid development of various Trop2-targeted therapies, notably marked by the advent of the antibody-drug conjugate (ADC), revolutionized the outcome for patients facing Trop2-positive tumors with limited treatment opinions, such as triple-negative breast cancer (TNBC). This review provides a comprehensive summary of advances in Trop2-targeted therapies, including ADCs, antibodies, multispecific agents, immunotherapy, cancer vaccines, and small molecular inhibitors, along with in-depth discussions on their designs, mechanisms of action (MOAs), and limitations. Additionally, we emphasize the clinical research progress of these emerging Trop2-targeted agents, focusing on their clinical application and therapeutic efficacy against tumors. Furthermore, we propose directions for future research, such as enhancing our understanding of Trop2's structure and biology, exploring the best combination strategies, and tailoring precision treatment based on Trop2 testing methodologies.
PSMA-PET follow-up to assess response in patients not receiving PSMA therapy: Is there value beyond localization of disease?
Authors: Alina T Küper, David Kersting, Tugce Telli, Ken Herrmann, Axel Rominger, Ali Afshar-Oromieh, Leonor Lopes, Sofia Karkampouna, Kuangyu Shi, Moon Kim, Boris Hadaschik, Christopher Darr, Lale Umutlu, Wolfgang P Fendler, Robert Seifert
Journal: Theranostics (2024)

Prostate Specific Membrane Antigen Positron Emission Tomography (PSMA-PET) is routinely used for the staging of patients with prostate cancer, but data on response assessment are sparse and primarily stem from metastatic castration-resistant prostate cancer (mCRPC) patients treated with PSMA radioligand therapy. Still, follow-up PSMA-PET is employed in earlier disease stages in case of clinical suspicion of disease persistence, recurrence or progression to decide if localized or systemic treatment is indicated. Therefore, the prognostic value of PSMA-PET derived tumor volumes in earlier disease stages (i.e., hormone-sensitive prostate cancer (HSPC) and non-[
Chronic stress dysregulates the Hippo/YAP/14-3-3η pathway and induces mitochondrial damage in basolateral amygdala in a mouse model of depression
Authors: Yan Zhao, Yulong Chen, Chihua Guo, Pingping Li, Zhao Cheng, Lei Zheng, Baoyong Sha, Hao Xu, Xingli Su, Yunpeng Wang
Journal: Theranostics (2024)

: Recent evidence highlights the pivotal role of mitochondrial dysfunction in mood disorders, but the mechanism involved remains unclear. We studied whether the Hippo/YAP/14-3-3η signaling pathway mediates mitochondrial abnormalities that result in the onset of major depressive disorder (MDD) in a mouse model.
Host and pathogen factors that influence variability of Mycobacterium tuberculosis lipid body content in sputum from patients with tuberculosis: an observational study
Authors: Baye G Tarekegn, Leopold D Tientcheu, Jonathan Decker, Andrew J Bell, Galina V Mukamolova, Beate Kampmann, Gashaw Messele, Tadeye Abeje, Abraham Aseffa, Hazel M Dockrell, Pranabashis Haldar, Michael R Barer, Natalie J Garton
Journal: The Lancet Microbe (2024)