Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the empa-kidney trial
Authors: N Staplin, R Haynes, PK Judge, C Wanner, JB Green, J Emberson, D Preiss, KJ Mayne, SYA Ng, E Sammons, D Zhu, M Hill, W Stevens, K Wallendszus, S Brenner, AK Cheung, ZH Liu, J Li, LS Hooi, WJ Liu, T Kadowaki, M Nangaku, A Levin, D Cherney, AP Maggioni, R Pontremoli, R Deo, S Goto, X Rossello, KR Tuttle, D Steubl, M Petrini, S Seidi, MJ Landray, C Baigent, WG Herrington, S Abat, R Abd Rahman, R Abdul Cader, MI Abdul Hafidz, MZ Abdul Wahab, NK Abdullah, T Abdul-Samad, M Abe, N Abraham, S Acheampong, P Achiri, JA Acosta, A Adeleke, V Adell, R Adewuyi-Dalton, N Adnan, A Africano, M Agharazii, F Aguilar, A Aguilera, M Ahmad, MK Ahmad, NA Ahmad, NH Ahmad, NI Ahmad, N Ahmad Miswan, H Ahmad Rosdi, I Ahmed, S Ahmed, S Ahmed, J Aiello, A Aitken, R AitSadi, S Aker, S Akimoto, A Akinfolarin, S Akram, F Alberici, C Albert, L Aldrich, M Alegata, L Alexander, S Alfaress, M Alhadj Ali, A Ali, A Ali, R Alicic, A Aliu, R Almaraz, R Almasarwah, J Almeida, A Aloisi, L Al-Rabadi, D Alscher, P Alvarez, B Al-Zeer, M Amat, C Ambrose, H Ammar, Y An, L Andriaccio, K Ansu, A Apostolidi, N Arai, H Araki, S Araki, A Arbi, O Arechiga, S Armstrong, T Arnold, S Aronoff, W Arriaga, J Arroyo, D Arteaga, S Asahara, A Asai, N Asai, S Asano, M Asawa, MF Asmee, F Aucella, M Augustin, A Avery, A Awad, IY Awang, M Awazawa, A Axler, W Ayub, Z Azhari, R Baccaro, C Badin, B Bagwell, E Bahlmann-Kroll, AZ Bahtar, C Baigent, D Bains, H Bajaj, R Baker, E Baldini, B Banas, D Banerjee, S Banno, S Bansal, S Barberi, S Barnes, C Barnini, C Barot, K Barrett, R Barrios, B Bartolomei Mecatti, I Barton, J Barton, W Basily, S Bavanandan, A Baxter, L Becker, S Beddhu, J Beige, S Beigh, S Bell, U Benck, A Beneat, A Bennett, D Bennett, S Benyon, J Berdeprado, T Bergler, A Bergner, M Berry, M Bevilacqua, J Bhairoo, S Bhandari, N Bhandary, A Bhatt, M Bhattarai, M Bhavsar, W Bian, F Bianchini, S Bianco, R Bilous, J Bilton, D Bilucaglia, C Bird, D Birudaraju, M Biscoveanu, C Blake, N Bleakley, K Bocchicchia, S Bodine, R Bodington, S Boedecker, M Bolduc, S Bolton, C Bond, F Boreky, K Boren, R Bouchi, L Bough, D Bovan, C Bowler, L Bowman, N Brar, C Braun, A Breach, M Breitenfeldt, S Brenner, B Brettschneider, A Brewer, G Brewer, V Brindle, E Brioni, C Brown, H Brown, L Brown, R Brown, S Brown, D Browne, K Bruce, M Brueckmann, N Brunskill, M Bryant, M Brzoska, Y Bu, C Buckman, M Budoff, M Bullen, A Burke, S Burnette, C Burston, M Busch, J Bushnell, S Butler, C Büttner, C Byrne, A Caamano, J Cadorna, C Cafiero, M Cagle, J Cai, K Calabrese, C Calvi, B Camilleri, S Camp, D Campbell, R Campbell, H Cao, I Capelli, M Caple, B Caplin, A Cardone, J Carle, V Carnall, M Caroppo, S Carr, G Carraro, M Carson, P Casares, C Castillo, C Castro, B Caudill, V Cejka, M Ceseri, L Cham, A Chamberlain, J Chambers, CBT Chan, JYM Chan, YC Chan, E Chang, E Chang, T Chant, T Chavagnon, P Chellamuthu, F Chen, J Chen, P Chen, TM Chen, Y Chen, Y Chen, C Cheng, H Cheng, MC Cheng, D Cherney, AK Cheung, CH Ching, N Chitalia, R Choksi, C Chukwu, K Chung, G Cianciolo, L Cipressa, S Clark, H Clarke, R Clarke, S Clarke, B Cleveland, E Cole, H Coles, L Condurache, A Connor, K Convery, A Cooper, N Cooper, Z Cooper, L Cooperman, L Cosgrove, P Coutts, A Cowley, R Craik, G Cui, T Cummins, N Dahl, H Dai, L Dajani, A D'Amelio, E Damian, K Damianik, L Danel, C Daniels, T Daniels, S Darbeau, H Darius, T Dasgupta, J Davies, L Davies, A Davis, J Davis, L Davis, R Dayanandan, S Dayi, R Dayrell, L De Nicola, S Debnath, W Deeb, S Degenhardt, K DeGoursey, M Delaney, R Deo, R DeRaad, V Derebail, D Dev, M Devaux, P Dhall, G Dhillon, J Dienes, M Dobre, E Doctolero, V Dodds, D Domingo, D Donaldson, P Donaldson, C Donhauser, V Donley, S Dorestin, S Dorey, T Doulton, D Draganova, K Draxlbauer, F Driver, H Du, F Dube, T Duck, T Dugal, J Dugas, H Dukka, H Dumann, W Durham, M Dursch, R Dykas, R Easow, E Eckrich, G Eden, E Edmerson, H Edwards, LW Ee, J Eguchi, Y Ehrl, K Eichstadt, W Eid, B Eilerman, Y Ejima, H Eldon, T Ellam, L Elliott, R Ellison, J Emberson, R Epp, A Er, M Espino-Obrero, S Estcourt, L Estienne, G Evans, J Evans, S Evans, G Fabbri, M Fajardo-Moser, C Falcone, F Fani, P Faria-Shayler, F Farnia, D Farrugia, M Fechter, D Fellowes, F Feng, J Fernandez, P Ferraro, A Field, S Fikry, J Finch, H Finn, P Fioretto, R Fish, A Fleischer, D Fleming-Brown, L Fletcher, R Flora, C Foellinger, N Foligno, S Forest, Z Forghani, K Forsyth, D Fottrell-Gould, P Fox, A Frankel, D Fraser, R Frazier, K Frederick, N Freking, H French, A Froment, B Fuchs, L Fuessl, H Fujii, A Fujimoto, A Fujita, K Fujita, Y Fujita, M Fukagawa, Y Fukao, A Fukasawa, T Fuller, T Funayama, E Fung, M Furukawa, Y Furukawa, M Furusho, S Gabel, J Gaidu, S Gaiser, K Gallo, C Galloway, G Gambaro, CC Gan, C Gangemi, M Gao, K Garcia, M Garcia, C Garofalo, M Garrity, A Garza, S Gasko, M Gavrila, B Gebeyehu, A Geddes, G Gentile, A George, J George, L Gesualdo, F Ghalli, A Ghanem, T Ghate, S Ghavampour, A Ghazi, A Gherman, U Giebeln-Hudnell, B Gill, S Gillham, I Girakossyan, M Girndt, A Giuffrida, M Glenwright, T Glider, R Gloria, D Glowski, BL Goh, CB Goh, T Gohda, R Goldenberg, R Goldfaden, C Goldsmith, B Golson, V Gonce, Q Gong, B Goodenough, N Goodwin, M Goonasekera, A Gordon, J Gordon, A Gore, H Goto, S Goto, S Goto, D Gowen, A Grace, J Graham, G Grandaliano, M Gray, JB Green, T Greene, G Greenwood, B Grewal, R Grifa, D Griffin, S Griffin, P Grimmer, E Grobovaite, S Grotjahn, A Guerini, C Guest, S Gunda, B Guo, Q Guo, S Haack, M Haase, K Haaser, K Habuki, A Hadley, S Hagan, S Hagge, H Haller, S Ham, S Hamal, Y Hamamoto, N Hamano, M Hamm, A Hanburry, M Haneda, C Hanf, W Hanif, J Hansen, L Hanson, S Hantel, T Haraguchi, E Harding, T Harding, C Hardy, C Hartner, Z Harun, L Harvill, A Hasan, H Hase, F Hasegawa, T Hasegawa, A Hashimoto, C Hashimoto, M Hashimoto, S Hashimoto, S Haskett, SJ Hauske, A Hawfield, T Hayami, M Hayashi, S Hayashi, R Haynes, A Hazara, C Healy, J Hecktman, G Heine, H Henderson, R Henschel, A Hepditch, K Herfurth, G Hernandez, A Hernandez Pena, C Hernandez-Cassis, WG Herrington, C Herzog, S Hewins, D Hewitt, L Hichkad, S Higashi, C Higuchi, C Hill, L Hill, M Hill, T Himeno, A Hing, Y Hirakawa, K Hirata, Y Hirota, T Hisatake, S Hitchcock, A Hodakowski, W Hodge, R Hogan, U Hohenstatt, B Hohenstein, L Hooi, S Hope, M Hopley, S Horikawa, D Hosein, T Hosooka, L Hou, W Hou, L Howie, A Howson, M Hozak, Z Htet, X Hu, Y Hu, J Huang, N Huda, L Hudig, A Hudson, C Hugo, R Hull, L Hume, W Hundei, N Hunt, A Hunter, S Hurley, A Hurst, C Hutchinson, T Hyo, FH Ibrahim, S Ibrahim, N Ihana, T Ikeda, A Imai, R Imamine, A Inamori, H Inazawa, J Ingell, K Inomata, Y Inukai, M Ioka, A Irtiza-Ali, T Isakova, W Isari, M Iselt, A Ishiguro, K Ishihara, T Ishikawa, T Ishimoto, K Ishizuka, R Ismail, S Itano, H Ito, K Ito, M Ito, Y Ito, S Iwagaitsu, Y Iwaita, T Iwakura, M Iwamoto, M Iwasa, H Iwasaki, S Iwasaki, K Izumi, K Izumi, T Izumi, SM Jaafar, C Jackson, Y Jackson, G Jafari, M Jahangiriesmaili, N Jain, K Jansson, H Jasim, L Jeffers, A Jenkins, M Jesky, J Jesus-Silva, D Jeyarajah, Y Jiang, X Jiao, G Jimenez, B Jin, Q Jin, J Jochims, B Johns, C Johnson, T Johnson, S Jolly, L Jones, L Jones, S Jones, T Jones, V Jones, M Joseph, S Joshi, P Judge, N Junejo, S Junus, M Kachele, T Kadowaki, H Kadoya, H Kaga, H Kai, H Kajio, W Kaluza-Schilling, L Kamaruzaman, A Kamarzarian, Y Kamimura, H Kamiya, C Kamundi, T Kan, Y Kanaguchi, A Kanazawa, E Kanda, S Kanegae, K Kaneko, K Kaneko, HY Kang, T Kano, M Karim, D Karounos, W Karsan, R Kasagi, N Kashihara, H Katagiri, A Katanosaka, A Katayama, M Katayama, E Katiman, K Kato, M Kato, N Kato, S Kato, T Kato, Y Kato, Y Katsuda, T Katsuno, J Kaufeld, Y Kavak, I Kawai, M Kawai, M Kawai, A Kawase, S Kawashima, A Kazory, J Kearney, B Keith, J Kellett, S Kelley, M Kershaw, M Ketteler, Q Khai, Q Khairullah, H Khandwala, KKL Khoo, A Khwaja, K Kidokoro, J Kielstein, M Kihara, C Kimber, S Kimura, H Kinashi, H Kingston, M Kinomura, E Kinsella-Perks, M Kitagawa, M Kitajima, S Kitamura, A Kiyosue, M Kiyota, F Klauser, G Klausmann, W Kmietschak, K Knapp, C Knight, A Knoppe, C Knott, M Kobayashi, R Kobayashi, T Kobayashi, M Koch, S Kodama, N Kodani, E Kogure, M Koizumi, H Kojima, T Kojo, N Kolhe, H Komaba, T Komiya, H Komori, SP Kon, M Kondo, M Kondo, W Kong, M Konishi, K Kono, M Koshino, T Kosugi, B Kothapalli, T Kozlowski, B Kraemer, A Kraemer-Guth, J Krappe, D Kraus, C Kriatselis, C Krieger, P Krish, B Kruger, KR Ku Md Razi, Y Kuan, S Kubota, S Kuhn, P Kumar, S Kume, I Kummer, R Kumuji, A Küpper, T Kuramae, L Kurian, C Kuribayashi, R Kurien, E Kuroda, T Kurose, A Kutschat, N Kuwabara, H Kuwata, G La Manna, M Lacey, K Lafferty, P LaFleur, V Lai, E Laity, A Lambert, MJ Landray, M Langlois, F Latif, E Latore, E Laundy, D Laurienti, A Lawson, M Lay, I Leal, I Leal, AK Lee, J Lee, KQ Lee, R Lee, SA Lee, YY Lee, Y Lee-Barkey, N Leonard, G Leoncini, CM Leong, S Lerario, A Leslie, A Levin, A Lewington, J Li, N Li, X Li, Y Li, L Liberti, ME Liberti, A Liew, YF Liew, U Lilavivat, SK Lim, YS Lim, E Limon, H Lin, E Lioudaki, H Liu, J Liu, L Liu, Q Liu, WJ Liu, X Liu, Z Liu, D Loader, H Lochhead, CL Loh, A Lorimer, L Loudermilk, J Loutan, CK Low, CL Low, YM Low, Z Lozon, Y Lu, D Lucci, U Ludwig, N Luker, D Lund, R Lustig, S Lyle, C Macdonald, I MacDougall, R Machicado, D MacLean, P Macleod, A Madera, F Madore, K Maeda, H Maegawa, S Maeno, M Mafham, J Magee, AP Maggioni, DY Mah, V Mahabadi, M Maiguma, Y Makita, G Makos, L Manco, R Mangiacapra, J Manley, P Mann, S Mano, G Marcotte, J Maris, P Mark, S Markau, M Markovic, C Marshall, M Martin, C Martinez, S Martinez, G Martins, K Maruyama, S Maruyama, K Marx, A Maselli, A Masengu, A Maskill, S Masumoto, K Masutani, M Matsumoto, T Matsunaga, N Matsuoka, M Matsushita, M Matthews, S Matthias, E Matvienko, M Maurer, P Maxwell, KJ Mayne, N Mazlan, SA Mazlan, A Mbuyisa, K McCafferty, F McCarroll, T McCarthy, C McClary-Wright, K McCray, P McDermott, C McDonald, R McDougall, E McHaffie, K McIntosh, T McKinley, S McLaughlin, N McLean, L McNeil, A Measor, J Meek, A Mehta, R Mehta, M Melandri, P Mené, T Meng, J Menne, K Merritt, S Merscher, C Meshykhi, P Messa, L Messinger, N Miftari, R Miller, Y Miller, E Miller-Hodges, M Minatoguchi, M Miners, R Minutolo, T Mita, Y Miura, M Miyaji, S Miyamoto, T Miyatsuka, M Miyazaki, I Miyazawa, R Mizumachi, M Mizuno, S Moffat, FS Mohamad Nor, SN Mohamad Zaini, FA Mohamed Affandi, C Mohandas, R Mohd, NA Mohd Fauzi, NH Mohd Sharif, Y Mohd Yusoff, L Moist, A Moncada, M Montasser, A Moon, C Moran, N Morgan, J Moriarty, G Morig, H Morinaga, K Morino, T Morisaki, Y Morishita, S Morlok, A Morris, F Morris, S Mostafa, Y Mostefai, M Motegi, N Motherwell, D Motta, A Mottl, R Moys, S Mozaffari, J Muir, J Mulhern, S Mulligan, Y Munakata, C Murakami, M Murakoshi, A Murawska, K Murphy, L Murphy, S Murray, H Murtagh, MA Musa, L Mushahar, R Mustafa, R Mustafar, M Muto, E Nadar, R Nagano, T Nagasawa, E Nagashima, H Nagasu, S Nagelberg, H Nair, Y Nakagawa, M Nakahara, J Nakamura, R Nakamura, T Nakamura, M Nakaoka, E Nakashima, J Nakata, M Nakata, S Nakatani, A Nakatsuka, Y Nakayama, G Nakhoul, M Nangaku, G Naverrete, A Navivala, I Nazeer, L Negrea, C Nethaji, E Newman, SYA Ng, TJ Ng, LLS Ngu, T Nimbkar, H Nishi, M Nishi, S Nishi, Y Nishida, A Nishiyama, J Niu, P Niu, G Nobili, N Nohara, I Nojima, J Nolan, H Nosseir, M Nozawa, M Nunn, S Nunokawa, M Oda, M Oe, Y Oe, K Ogane, W Ogawa, T Ogihara, G Oguchi, M Ohsugi, K Oishi, Y Okada, J Okajyo, S Okamoto, K Okamura, O Olufuwa, R Oluyombo, A Omata, Y Omori, LM Ong, YC Ong, J Onyema, A Oomatia, A Oommen, R Oremus, Y Orimo, V Ortalda, Y Osaki, Y Osawa, J Osmond Foster, A O'Sullivan, T Otani, N Othman, S Otomo, J O'Toole, L Owen, T Ozawa, A Padiyar, N Page, S Pajak, A Paliege, A Pandey, R Pandey, H Pariani, J Park, M Parrigon, J Passauer, M Patecki, M Patel, R Patel, T Patel, Z Patel, R Paul, R Paul, L Paulsen, L Pavone, A Peixoto, J Peji, BC Peng, K Peng, L Pennino, E Pereira, E Perez, P Pergola, F Pesce, G Pessolano, W Petchey, EJ Petr, T Pfab, P Phelan, R Phillips, T Phillips, M Phipps, G Piccinni, T Pickett, S Pickworth, M Piemontese, D Pinto, J Piper, J Plummer-Morgan, D Poehler, L Polese, V Poma, R Pontremoli, A Postal, C Pötz, A Power, N Pradhan, R Pradhan, D Preiss, E Preiss, K Preston, N Prib, L Price, C Provenzano, C Pugay, R Pulido, F Putz, Y Qiao, R Quartagno, M Quashie-Akponeware, R Rabara, R Rabasa-Lhoret, D Radhakrishnan, M Radley, R Raff, S Raguwaran, F Rahbari-Oskoui, M Rahman, K Rahmat, S Ramadoss, S Ramanaidu, S Ramasamy, R Ramli, S Ramli, T Ramsey, A Rankin, A Rashidi, L Raymond, WAFA Razali, K Read, H Reiner, A Reisler, C Reith, J Renner, B Rettenmaier, L Richmond, D Rijos, R Rivera, V Rivers, H Robinson, M Rocco, I Rodriguez-Bachiller, R Rodriquez, C Roesch, J Roesch, J Rogers, M Rohnstock, S Rolfsmeier, M Roman, A Romo, A Rosati, S Rosenberg, T Ross, X Rossello, M Roura, M Roussel, S Rovner, S Roy, S Rucker, L Rump, M Ruocco, S Ruse, F Russo, M Russo, M Ryder, A Sabarai, C Saccà, R Sachson, E Sadler, NS Safiee, M Sahani, A Saillant, J Saini, C Saito, S Saito, K Sakaguchi, M Sakai, H Salim, C Salviani, E Sammons, A Sampson, F Samson, P Sandercock, S Sanguila, G Santorelli, D Santoro, N Sarabu, T Saram, R Sardell, H Sasajima, T Sasaki, S Satko, A Sato, D Sato, H Sato, H Sato, J Sato, T Sato, Y Sato, M Satoh, K Sawada, M Schanz, F Scheidemantel, M Schemmelmann, E Schettler, V Schettler, GR Schlieper, C Schmidt, G Schmidt, U Schmidt, H Schmidt-Gurtler, M Schmude, A Schneider, I Schneider, C Schneider-Danwitz, M Schomig, T Schramm, A Schreiber, S Schricker, B Schroppel, L Schulte-Kemna, E Schulz, B Schumacher, A Schuster, A Schwab, F Scolari, A Scott, W Seeger, W Seeger, M Segal, L Seifert, M Seifert, M Sekiya, R Sellars, MR Seman, S Shah, S Shah, L Shainberg, M Shanmuganathan, F Shao, K Sharma, C Sharpe, M Sheikh-Ali, J Sheldon, C Shenton, A Shepherd, M Shepperd, R Sheridan, Z Sheriff, Y Shibata, T Shigehara, K Shikata, K Shimamura, H Shimano, Y Shimizu, H Shimoda, K Shin, G Shivashankar, N Shojima, R Silva, CSB Sim, K Simmons, S Sinha, T Sitter, S Sivanandam, M Skipper, K Sloan, L Sloan, R Smith, J Smyth, T Sobande, M Sobata, S Somalanka, X Song, F Sonntag, B Sood, SY Sor, J Soufer, H Sparks, G Spatoliatore, T Spinola, S Squyres, A Srivastava, J Stanfield, N Staplin, K Staylor, A Steele, O Steen, D Steffl, J Stegbauer, C Stellbrink, E Stellbrink, W Stevens, A Stevenson, V Stewart-Ray, J Stickley, D Stoffler, B Stratmann, S Streitenberger, F Strutz, J Stubbs, J Stumpf, N Suazo, P Suchinda, R Suckling, A Sudin, K Sugamori, H Sugawara, K Sugawara, D Sugimoto, H Sugiyama, H Sugiyama, T Sugiyama, M Sullivan, M Sumi, N Suresh, D Sutton, H Suzuki, R Suzuki, Y Suzuki, Y Suzuki, Y Suzuki, E Swanson, P Swift, S Syed, H Szerlip, M Taal, M Taddeo, C Tailor, K Tajima, M Takagi, K Takahashi, K Takahashi, M Takahashi, T Takahashi, E Takahira, T Takai, M Takaoka, J Takeoka, A Takesada, M Takezawa, M Talbot, J Taliercio, T Talsania, Y Tamori, R Tamura, Y Tamura, CHH Tan, EZZ Tan, A Tanabe, K Tanabe, A Tanaka, A Tanaka, N Tanaka, S Tang, Z Tang, K Tanigaki, M Tarlac, A Tatsuzawa, JF Tay, LL Tay, J Taylor, K Taylor, K Taylor, A Te, L Tenbusch, KS Teng, A Terakawa, J Terry, ZD Tham, S Tholl, G Thomas, KM Thong, D Tietjen, A Timadjer, H Tindall, S Tipper, K Tobin, N Toda, A Tokuyama, M Tolibas, A Tomita, T Tomita, J Tomlinson, L Tonks, J Topf, S Topping, A Torp, A Torres, F Totaro, P Toth, Y Toyonaga, F Tripodi, K Trivedi, E Tropman, D Tschope, J Tse, K Tsuji, S Tsunekawa, R Tsunoda, B Tucky, S Tufail, A Tuffaha, E Turan, H Turner, J Turner, M Turner, KR Tuttle, YL Tye, A Tyler, J Tyler, H Uchi, H Uchida, T Uchida, T Uchida, T Udagawa, S Ueda, Y Ueda, K Ueki, S Ugni, E Ugwu, R Umeno, C Unekawa, K Uozumi, K Urquia, A Valleteau, C Valletta, R van Erp, C Vanhoy, V Varad, R Varma, A Varughese, P Vasquez, A Vasseur, R Veelken, C Velagapudi, K Verdel, S Vettoretti, G Vezzoli, V Vielhauer, R Viera, E Vilar, S Villaruel, L Vinall, J Vinathan, M Visnjic, E Voigt, M von-Eynatten, M Vourvou, J Wada, J Wada, T Wada, Y Wada, K Wakayama, Y Wakita, K Wallendszus, T Walters, WH Wan Mohamad, L Wang, W Wang, X Wang, X Wang, Y Wang, C Wanner, S Wanninayake, H Watada, K Watanabe, K Watanabe, M Watanabe, H Waterfall, D Watkins, S Watson, L Weaving, B Weber, Y Webley, A Webster, M Webster, M Weetman, W Wei, H Weihprecht, L Weiland, J Weinmann-Menke, T Weinreich, R Wendt, Y Weng, M Whalen, G Whalley, R Wheatley, A Wheeler, J Wheeler, P Whelton, K White, B Whitmore, S Whittaker, J Wiebel, J Wiley, L Wilkinson, M Willett, A Williams, E Williams, K Williams, T Williams, A Wilson, P Wilson, L Wincott, E Wines, B Winkelmann, M Winkler, B Winter-Goodwin, J Witczak, J Wittes, M Wittmann, G Wolf, L Wolf, R Wolfling, C Wong, E Wong, HS Wong, LW Wong, YH Wong, A Wonnacott, A Wood, L Wood, H Woodhouse, N Wooding, A Woodman, K Wren, J Wu, P Wu, S Xia, H Xiao, X Xiao, Y Xie, C Xu, Y Xu, H Xue, H Yahaya, H Yalamanchili, A Yamada, N Yamada, K Yamagata, M Yamaguchi, Y Yamaji, A Yamamoto, S Yamamoto, S Yamamoto, T Yamamoto, A Yamanaka, T Yamano, Y Yamanouchi, N Yamasaki, Y Yamasaki, Y Yamasaki, C Yamashita, T Yamauchi, Q Yan, E Yanagisawa, F Yang, L Yang, S Yano, S Yao, Y Yao, S Yarlagadda, Y Yasuda, V Yiu, T Yokoyama, S Yoshida, E Yoshidome, H Yoshikawa, A Young, T Young, V Yousif, H Yu, Y Yu, K Yuasa, N Yusof, N Zalunardo, B Zander, R Zani, F Zappulo, M Zayed, B Zemann, P Zettergren, H Zhang, L Zhang, L Zhang, N Zhang, X Zhang, J Zhao, L Zhao, S Zhao, Z Zhao, H Zhong, N Zhou, S Zhou, D Zhu, L Zhu, S Zhu, M Zietz, M Zippo, F Zirino, FH Zulkipli
Journal: The Lancet Diabetes & Endocrinology (2023)

Sodium-glucose co-transporter-2 (SGLT2) inhibitors reduce progression of chronic kidney disease and the risk of cardiovascular morbidity and mortality in a wide range of patients. However, their effects on kidney disease progression in some patients with chronic kidney disease are unclear because few clinical kidney outcomes occurred among such patients in the completed trials. In particular, some guidelines stratify their level of recommendation about who should be treated with SGLT2 inhibitors based on diabetes status and albuminuria. We aimed to assess the effects of empagliflozin on progression of chronic kidney disease both overall and among specific types of participants in the EMPA-KIDNEY trial.