THE EFFECT AND RATE OF REMOVAL OF PYRUVIC ACID ADMINISTERED TO NORMAL PERSONS AND TO PATIENTS WITH AND WITHOUT "VITAMIN B DEFICIENCY"
Authors: Robert W. Wilkins, Soma Weiss, F. H. L. Taylor
Journal: Annals of Internal Medicine (1939)

Article1 January 1939THE EFFECT AND RATE OF REMOVAL OF PYRUVIC ACID ADMINISTERED TO NORMAL PERSONS AND TO PATIENTS WITH AND WITHOUT "VITAMIN B DEFICIENCY"ROBERT W. WILKINS, M.D., SOMA WEISS, M.D., F.A.C.P., F. H. L. TAYLOR, Ph.D.ROBERT W. WILKINS, M.D.Search for more papers by this author, SOMA WEISS, M.D., F.A.C.P.Search for more papers by this author, F. H. L. TAYLOR, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-7-938 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPyruvic acid has long been known as an intermediary product of carbohydrate metabolism. Nevertheless, there are but few reports on the pharmacological action of this substance in higher animals1, 2and, so far as we know, none on its action in human beings. Recently, considerable importance has been attached to pyruvic acid, chiefly through the rôle claimed for it in vitamin B1deficiencies. Peters and his coworkers3consider it an important, if not a specific substance in the "biochemical lesion" in experimental B1deficiency states, while Platt and Lu4report increased amounts of pyruvic acid in the blood, spinal fluid...Bibliography1. ISSIKIMATSUSHIMA TH: Ein Beitrag zur Pharmakologie der Phenylbrenztraubensäure, Folia pharmacol. japon., 1931, xi, 261; Abstract: Chem. Abstr., 1931, xxv, 2196. Google Scholar2. PUGLIESEROMOLI-VENTURI AD: Contributo alla terapia calcica. Il piruvato di calcio, Minerva med., 1931, i, 366. Google Scholar3. PETERS RA: The biochemical lesion in vitamin B1 deficiency, Lancet, 1936, i, 1161. CrossrefGoogle Scholar4. PLATTLU BSGD: Chemical and clinical findings in beri-beri with special reference to vitamin B1 deficiency, Quart. Jr. Med., 1936, v, 355. Google Scholar5. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySimultaneous determination of lactic acid and pyruvic acid in tissue and cell culture media by gas chromatography after in situ derivatization-ultrasound-assisted emulsification microextractionExperimentelle Untersuchung über die Vitamin B1-Versorgung der großstädtischen Bevölkerung in den Jahren 1941/42 und 43Responses of the normal heart and the heart in experimental vitamin B1 deficiency to metabolites (pyruvic acid, lactic acid, methyl glyoxal, glyceraldehyde, and adenylic acid) and to thiamin 1 January 1939Volume 12, Issue 7Page: 938-950KeywordsBloodCarbohydrate metabolismHospital medicineLesionsMedical servicesResearch laboratories ePublished: 1 December 2008 Issue Published: 1 January 1939 PDF downloadLoading ...