tbuckley/cabot-search huggingface dataset:
Oxytocin-Augmented Modular-Based Group Intervention for Loneliness: A Proof-Of-Concept Randomized Controlled Trial
Authors: Ruben Berger, Rene Hurlemann, Simone Shamay-Tsoory, Alisa Kanterman, Maura Brauser, Jessica Gorni, Maike Luhmann, Elisabeth Schramm, Johannes Schultz, Alexandra Philipsen, Jana Lieberz, Dirk Scheele
Journal: Psychotherapy and Psychosomatics (2024)

Loneliness poses a significant health problem and existing psychological interventions have shown only limited positive effects on loneliness. Based on preliminary evidence for impaired oxytocin signaling in trait-like loneliness, the current proof-of-concept study used a randomized, double-blind, placebo-controlled design to probe intranasal oxytocin (OT) as an adjunct to a short-term modular-based group intervention for individuals suffering from high trait-like loneliness (HL, UCLA Loneliness Scale ≥55).
Outcomes of younger patients with mantle-cell lymphoma experiencing late relapse (&amp;gt;24 months): the LATE-POD study
Authors: Chiara Malinverni, Andrea Bernardelli, Ingrid Glimelius, Massimo Mirandola, Karin E. Ekstrom Smedby, Maria Chiara Tisi, Eva Giné, Alexandra Albertsson-Lindblad, Ana Marin-Niebla, Alice Di Rocco, Filipa Moita, Roberta Sciarra, Sandra Bašić-Kinda, Georg R Hess, Anke Ohler, Christian W. Eskelund, Alessandro Re, Isacco Ferrarini, Arne Kolstad, Riikka Katariina Räty, Francesca Maria Quaglia, Toby A. Eyre, Greta Scapinello, Piero Maria Stefani, Lucia Morello, Luca Nassi, Stefan Hohaus, Simone Ragaini, Vittorio Ruggero Zilioli, Riccardo Bruna, Federica Cocito, Annalisa Arcari, Mats Jerkeman, Carlo Visco
Journal: Blood (2024)
Error in the Exclusion of Participants From Analysis in the ACTIV-6 Platform Randomized Clinical Trial
Authors: Susanna Naggie
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of puberty suppression on bone, body composition, handgrip strength and glucolipid profile in early-pubertal transgender adolescents
Authors: Silvia Ciancia, Vanessa Dubois, Margarita Craen, Daniel Klink, Charlotte Verroken, Dirk Vanderschueren, Martine Cools
Journal: International Journal of Transgender Health (2024)

Introduction The effects of puberty suppression for more than 2 years before the start of gender-affirming hormones (GAH) on bone mass acquisition and body composition are understudied.
Increased incidence of co-trimoxazole-induced rash in patients on systemic corticosteroid treatment for toxicity associated with immune checkpoint inhibitors
Authors: Daniel Yiu, Silvia Aguilar-Duran, Charlotte Edwards, Dharmisha Chauhan, Andrew Furness, Samra Turajlic, James Larkin, Louise Fearfield, Kara Heelan
Journal: British Journal of Dermatology (2024)

Our cross-sectional study demonstrates that there is a high rate of co-trimoxazole-induced drug rash in patients treated for immune-related adverse events, with those developing rash appearing to have a reduced survival.
Single-cell transcriptomes and chromatin accessibility of endothelial cells unravel transcription factors associated with dysregulated angiogenesis in systemic sclerosis
Authors: Mengqi Huang, Tracy Tabib, Dinesh Khanna, Shervin Assassi, Robyn Domsic, Robert Lafyatis
Journal: Annals of the Rheumatic Diseases (2024)

Vasculopathy emerges early in systemic sclerosis (SSc) and links to endothelial cell (EC) injury and angiogenesis. Understanding EC transcriptomes and epigenomes is crucial for unravelling the mechanisms involved.
Remission and low disease activity are associated with lower healthcare costs: results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort
Authors: Megan R W Barber, Manuel Francisco Ugarte-Gil, John G Hanly, Murray B Urowitz, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J Wallace, David A Isenberg, Anisur Rahman, Joan T Merrill, Paul R Fortin, Dafna D Gladman, Ian N Bruce, Michelle Petri, Ellen M Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jönsen, Ronald F van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, S Sam Lim, Murat Inanc, Kenneth C Kalunian, Søren Jacobsen, Christine A Peschken, Diane L Kamen, Anca Askanase, Bernardo A Pons-Estel, Francesca S Cardwell, Graciela S Alarcón, Ann E Clarke
Journal: Annals of the Rheumatic Diseases (2024)

This study aims to determine the independent impact of definitions of remission/low disease activity (LDA) on direct/indirect costs (DCs, ICs) in a multicentre inception cohort.
Mechanical heterogeneity in a soft biomaterial niche controls BMP2 signaling
Authors: Erik Brauer, Aaron Herrera, Raphaela Fritsche-Guenther, Sophie Görlitz, Hans Leemhuis, Petra Knaus, Jennifer A. Kirwan, Georg N. Duda, Ansgar Petersen
Journal: Biomaterials (2024)

The extracellular matrix is known to impact cell function during regeneration by modulating growth factor signaling. However, how the mechanical properties and structure of biomaterials can be used to optimize the cellular response to growth factors is widely neglected. Here, we engineered a macroporous biomaterial to study cellular signaling in environments that mimic the mechanical stiffness but also the mechanical heterogeneity of native extracellular matrix. We found that the mechanical interaction of cells with the heterogeneous and non-linear deformation properties of soft matrices (E<5kPa) enhances BMP-2 growth factor signaling with high relevance for tissue regeneration. In contrast, this effect is absent in homogeneous hydrogels that are often used to study cell responses to mechanical cues. Live cell imaging and in silico finite element modeling further revealed that a subpopulation of highly active, fast migrating cells is responsible for most of the material deformation, while a second, less active population experiences this deformation as an extrinsic mechanical stimulation. At an overall low cell density, the active cell population dominates the process, suggesting that it plays a particularly important role in early tissue healing scenarios where cells invade tissue defects or implanted biomaterials. Taken together, our findings demonstrate that the mechanical heterogeneity of the natural extracellular matrix environment plays an important role in triggering regeneration by endogenously acting growth factors. This suggests the inclusion of such mechanical complexity as a design parameter in future biomaterials, in addition to established parameters such as mechanical stiffness and stress relaxation.
A Functional Survey of the Regulatory Landscape of Estrogen Receptor–Positive Breast Cancer Evolution
Authors: Iros Barozzi, Neil Slaven, Eleonora Canale, Rui Lopes, Inês Amorim Monteiro Barbosa, Melusine Bleu, Diana Ivanoiu, Claudia Pacini, Emanuela Mensa’, Alfie Chambers, Sara Bravaccini, Sara Ravaioli, Balázs Győrffy, Maria Vittoria Dieci, Giancarlo Pruneri, Giorgio Giacomo Galli, Luca Magnani
Journal: Cancer Discovery (2024)

Abstract Only a handful of somatic alterations have been linked to endocrine therapy resistance in hormone-dependent breast cancer, potentially explaining ∼40% of relapses. If other mechanisms underlie the evolution of hormone-dependent breast cancer under adjuvant therapy is currently unknown. In this work, we employ functional genomics to dissect the contribution of cis-regulatory elements (CRE) to cancer evolution by focusing on 12 megabases of noncoding DNA, including clonal enhancers, gene promoters, and boundaries of topologically associating domains. Parallel epigenetic perturbation (CRISPRi) in vitro reveals context-dependent roles for many of these CREs, with a specific impact on dormancy entrance and endocrine therapy resistance. Profiling of CRE somatic alterations in a unique, longitudinal cohort of patients treated with endocrine therapies identifies a limited set of noncoding changes potentially involved in therapy resistance. Overall, our data uncover how endocrine therapies trigger the emergence of transient features which could ultimately be exploited to hinder the adaptive process. Significance: This study shows that cells adapting to endocrine therapies undergo changes in the usage or regulatory regions. Dormant cells are less vulnerable to regulatory perturbation but gain transient dependencies which can be exploited to decrease the formation of dormant persisters.
U.S. Preparedness and Response to Increasing Clade I Mpox Cases in the Democratic Republic of the Congo — United States, 2024
Authors: Jennifer H. McQuiston, Richard Luce, Dieudonne Mwamba Kazadi, Christian Ngandu Bwangandu, Placide Mbala-Kingebeni, Mark Anderson, Joanna M. Prasher, Ian T. Williams, Amelia Phan, Victoria Shelus, Anna Bratcher, Gnakub Norbert Soke, Peter N. Fonjungo, Joelle Kabamba, Andrea M. McCollum, Robert Perry, Agam K. Rao, Jeff Doty, Bryan Christensen, James A. Fuller, Nicolle Baird, Jasmine Chaitram, Christopher K. Brown, Amy E. Kirby, David Fitter, Jennifer M. Folster, Mushtaq Dualeh, Regan Hartman, Stephen M. Bart, Christine M. Hughes, Yoshinori Nakazawa, Emily Sims, Athalia Christie, Christina L. Hutson
Journal: MMWR Morbidity and Mortality Weekly Report (2024)

Clade I monkeypox virus (MPXV), which can cause severe illness in more people than clade II MPXVs, is endemic in the Democratic Republic of the Congo (DRC), but the country has experienced an increase in suspected cases during 2023-2024.In light of the 2022 global outbreak of clade II mpox, the increase in suspected clade I cases in DRC raises concerns that the virus could spread to other countries and underscores the importance of coordinated, urgent global action to support DRC's efforts to contain the virus.To date, no cases of clade I mpox have been detected outside of countries in Central Africa where the virus is endemic.CDC and other partners are working to support DRC's response.In addition, CDC is enhancing U.S. preparedness by raising awareness, strengthening surveillance, expanding diagnostic testing capacity for clade I MPXV, ensuring appropriate specimen handling and waste management, emphasizing the importance of appropriate medical treatment, and communicating guidance on the recommended contact tracing, containment, behavior modification, and vaccination strategies.
Measles Outbreak Associated with a Migrant Shelter — Chicago, Illinois, February–May 2024
Authors: Kimberly Gressick, Amy Nham, Thomas D. Filardo, Kendall Anderson, Stephanie R. Black, Katherine Boss, Maribel Chavez-Torres, Shelby Daniel-Wayman, Peter Dejonge, Emily Faherty, Michelle Funk, Janna Kerins, Do Young Kim, Alyse Kittner, Colin Korban, Massimo Pacilli, Anne Schultz, Alexander Sloboda, Shane Zelencik, Arti Barnes, Joshua J. Geltz, Jodi Morgan, Kyran Quinlan, Heather Reid, Kevin Chatham-Stephens, Tatiana M. Lanzieri, Jessica Leung, Chelsea S. Lutz, Ponesai Nyika, Kelley Raines, Sumathi Ramachandran, Maria I. Rivera, Jordan Singleton, Dennis Wang, Paul A. Rota, David Sugerman, Stephanie Gretsch, Brian F. Borah, Ashley Becht, Danielle Belanger, Marco Ciaccio, Anna Esquivel, Molly Gabaldo, Kevin Hansen, David Juen, Gira Patel, Bethlehem Solomon, Karrie-Ann Toews, Christy Zelinski
Journal: MMWR Morbidity and Mortality Weekly Report (2024)

Measles, a highly contagious respiratory virus with the potential to cause severe complications, hospitalization, and death, was declared eliminated from the United States in 2000; however, with ongoing global transmission, infections in the United States still occur.On March 7, 2024, the Chicago Department of Public Health (CDPH) confirmed a case of measles in a male aged 1 year residing in a temporary shelter for migrants in Chicago.Given the congregate nature of the setting, high transmissibility of measles, and low measles vaccination coverage among shelter residents, measles virus had the potential to spread rapidly among approximately 2,100 presumed exposed shelter residents.CDPH immediately instituted outbreak investigation and response activities in collaboration with state and local health departments, health care facilities, city agencies, and shelters.On March 8, CDPH implemented active case-finding and coordinated a mass vaccination campaign at the affected shelter (shelter A), including vaccinating 882 residents and verifying previous vaccination for 784 residents over 3 days.These activities resulted in 93% measles vaccination coverage (defined as receipt of ≥1 recorded measles vaccine dose) by March 11.By May 13, a total of 57 confirmed measles cases associated with residing in or having contact with persons from shelter A had been reported.Most cases (41; 72%) were among persons who did not have documentation of measles vaccination and were considered unvaccinated.In addition, 16 cases of measles occurred among * These authors contributed equally to this report.persons who had received ≥1 measles vaccine dose ≥21 days before first known exposure.This outbreak underscores the need to ensure high vaccination coverage among communities residing in congregate settings. Investigation and ResultsMeasles is a highly contagious respiratory virus with the potential to cause severe complications, hospitalization, and death (1).Although measles was declared eliminated from the United States in 2000, global transmission is ongoing (2).Receipt of 1 and 2 doses of measles vaccine is 93% and 97% effective, respectively, in preventing measles (1).
Progress Toward Poliomyelitis Eradication — Worldwide, January 2022–December 2023
Authors: Keri Geiger, Tasha Stehling-Ariza, John Paul Bigouette, Sarah D. Bennett, Cara C. Burns, Arshad Quddus, Steven G.F. Wassilak, Omotayo Bolu
Journal: MMWR Morbidity and Mortality Weekly Report (2024)

In 1988, poliomyelitis (polio) was targeted for eradication.Global efforts have led to the eradication of two of the three wild poliovirus (WPV) serotypes (types 2 and 3), with only WPV type 1 (WPV1) remaining endemic, and only in Afghanistan and Pakistan.This report describes global polio immunization, surveillance activities, and poliovirus epidemiology during January 2022-December 2023, using data current as of April 10, 2024.In 2023, Afghanistan and Pakistan identified 12 total WPV1 polio cases, compared with 22 in 2022.WPV1 transmission was detected through systematic testing for poliovirus in sewage samples (environmental surveillance) in 13 provinces in Afghanistan and Pakistan, compared with seven provinces in 2022.The number of polio cases caused by circulating vaccine-derived polioviruses (cVDPVs; circulating vaccine virus strains that have reverted to neurovirulence) decreased from 881 in 2022 to 524 in 2023; cVDPV outbreaks (defined as either a cVDPV case with evidence of circulation or at least two positive environmental surveillance isolates) occurred in 32 countries in 2023, including eight that did not experience a cVDPV outbreak in 2022.Despite reductions in paralytic polio cases from 2022, cVDPV cases and WPV1 cases (in countries with endemic transmission) were more geographically widespread in 2023.Renewed efforts to vaccinate persistently missed children in countries and territories where WPV1 transmission is endemic, strengthen routine immunization programs in countries at high risk for poliovirus transmission, and provide more effective cVDPV outbreak responses are necessary to further progress toward global polio eradication.* POLIS is a centralized database that integrates polio case-based and environmental surveillance, with supplemental immunization activity data from all WHO regions.https://extranet.who.int/polis(Access is limited to members of GPEI partner organizations).
Treating necrotizing skin and soft-tissue infections
Authors: Philippe Montravers, Anna Norrby-Teglund, Patricia Munoz
Journal: Intensive Care Medicine (2024)

Among skin and soft-tissue infections, necrotizing skin and soft-tissue infections (NSTIs) are by far the most frequent and the most severe cases admitted to the intensive care unit (ICU).Timely and adequate surgical and medical care are the only modifiable features in their management [1].The heterogeneity of patients, including varying comorbidities, clinical presentations, causative microbes and treatments, requires a team approach involving multidisciplinary management [2,3]. Early diagnosisTypical cases are usually readily identified on clinical grounds, leading to early emergency admission and source control.In contrast, underestimation of the burden of comorbidities, slow onset or atypical symptoms without sepsis, are common risk factors for delayed diagnosis, and late adequate care.Immunocompromised patients are at particular risk and should be considered severe cases [3,4].NSTIs can affect any part of the body, most commonly the extremities, pelvix and cervix [4,5].Initial misdiagnosis, admission of these patients to a nonacute care surgery service, or interhospital transfer to tertiary centers before source control represent the most common reasons for belated surgical management.
Music Therapy in Infancy and Neurodevelopmental Outcomes in Preterm Children
Authors: Łucja Bieleninik, Ingrid Kvestad, Christian Gold, Andreas Størksen Stordal, Jörg Assmus, Shmuel Arnon, Cochavit Elefant, Mark Ettenberger, Tora Söderström Gaden, Dafna Haar-Shamir, Tonje Håvardstun, Marcela Lichtensztejn, Julie Mangersnes, Anne-Marthe Nygård Wiborg, Bente Johanne Vederhus, Claire M. Ghetti
Journal: JAMA Network Open (2024)

Preterm children are at risk for neurodevelopment impairments.
Effectiveness of a Web-Based Cognitive Behavioral Self-Help Intervention for Binge Eating Disorder
Authors: Luise Pruessner, Christina Timm, Sven Barnow, Julian A. Rubel, Christopher Lalk, Steffen Hartmann
Journal: JAMA Network Open (2024)

Binge eating disorder (BED) is one of the most frequent eating pathologies and imposes substantial emotional and physical distress, yet insufficient health care resources limit access to specialized treatment. Web-based self-help interventions emerge as a promising solution, offering more accessible care.
Pharmacogenomics, Race, and Treatment Outcome in Pediatric Acute Myeloid Leukemia
Authors: Jatinder K. Lamba, Richard Marrero, Huiyun Wu, Xueyuan Cao, Phani Krisha Parcha, Seth E. Karol, Hiroto Inaba, Dennis John Kuo, Barbara A. Degar, Kenneth Heym, Jeffrey W. Taub, Norman J. Lacayo, Ching-Hon Pui, Raul C. Ribeiro, Stanley B. Pounds, Jeffrey E. Rubnitz
Journal: JAMA Network Open (2024)

Disparities in outcomes exist between Black and White patients with acute myeloid leukemia (AML), with Black patients experiencing poorer prognosis compared with their White counterparts.
ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—2024 update
Authors: Jitka Malcikova, Sarka Pavlova, Panagiotis Baliakas, Thomas Chatzikonstantinou, Eugen Tausch, Mark Catherwood, Davide Rossi, Thierry Soussi, Boris Tichy, Arnon P. Kater, Carsten U. Niemann, Frederic Davi, Gianluca Gaidano, Stephan Stilgenbauer, Richard Rosenquist, Kostas Stamatopoulos, Paolo Ghia, Sarka Pospisilova
Journal: Leukemia (2024)

In chronic lymphocytic leukemia (CLL), analysis of TP53 aberrations (deletion and/or mutation) is a crucial part of treatment decision-making algorithms. Technological and treatment advances have resulted in the need for an update of the last recommendations for TP53 analysis in CLL, published by ERIC, the European Research Initiative on CLL, in 2018. Based on the current knowledge of the relevance of low-burden TP53-mutated clones, a specific variant allele frequency (VAF) cut-off for reporting TP53 mutations is no longer recommended, but instead, the need for thorough method validation by the reporting laboratory is emphasized. The result of TP53 analyses should always be interpreted within the context of available laboratory and clinical information, treatment indication, and therapeutic options. Methodological aspects of introducing next-generation sequencing (NGS) in routine practice are discussed with a focus on reliable detection of low-burden clones. Furthermore, potential interpretation challenges are presented, and a simplified algorithm for the classification of TP53 variants in CLL is provided, representing a consensus based on previously published guidelines. Finally, the reporting requirements are highlighted, including a template for clinical reports of TP53 aberrations. These recommendations are intended to assist diagnosticians in the correct assessment of TP53 mutation status, but also physicians in the appropriate understanding of the lab reports, thus decreasing the risk of misinterpretation and incorrect management of patients in routine practice whilst also leading to improved stratification of patients with CLL in clinical trials.
Calculation of Overall Hospital Quality Star Ratings With and Without Inclusion of the Peer Grouping Step
Authors: Cameron J. Gettel, Kyle Bagshaw, Li Qin, Zhenqiu Lin, Eve Rothenberg, Prince Omotosho, Demetri P. Goutos, Jeph Herrin, Lisa G. Suter, Michelle Schreiber, Lee A. Fleisher, Raquel Myers, Steven B. Spivack, Arjun K. Venkatesh
Journal: JAMA Network Open (2024)

The Centers for Medicare & Medicaid Services (CMS) Overall Star Rating is widely used by patients and consumers, and there is continued stakeholder curiosity surrounding the inclusion of a peer grouping step, implemented to the 2021 Overall Star Rating methods.
Trends in Industry-Sponsored Research Payments to Physician Principal Investigators
Authors: Zhuo T. Su, Zeyad Hammadeh, Joseph G. Cheaib, Yuezhou Jing, Bruce J. Trock, Misop Han
Journal: JAMA Network Open (2024)

This cohort study investigates trends in total and per-physician industry-sponsored research payments to physician principal investigators from 2015 to 2022.
AI-Generated Clinical Summaries
Authors: Charlaine Chen, Joseph E. Thornton
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal