tbuckley/cabot-search huggingface dataset:
AB1249 THE MONOCYTE-TO-HIGH-DENSITY LIPOPROTEIN-CHOLESTEROL RATIO AT DIAGNOSIS IS ASSOCIATED WITH CEREBROVASCULAR ACCIDENT DURING FOLLOW-UP IN PATIENTS WITH ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS
Authors: J. W. Ha, S. W. Lee
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> The monocyte-to-high-density lipoprotein-cholesterol (HDL-cholesterol) ratio (MHR) was introduced, and MHR at diagnosis or study entry was reported to be associated with all-cause mortality, acute coronary syndrome (ACS), and atherosclerosis. <h3>Objectives:</h3> In this study, the association between the MHR at diagnosis and poor outcomes of atherosclerosis-related antineutrophil cytoplasmic antibody-associated vasculitis (AAV) during follow-up in patients with AAV was investigated. <h3>Methods:</h3> This retrospective study included 138 patients diagnosed with AAV. Their comprehensive medical records were meticulously reviewed. All-cause mortality, cerebrovascular accident (CVA), and ACS were evaluated as atherosclerosis-related poor outcomes of AAV. MHR was obtained by dividing monocyte counts (/mm3) by HDL-cholesterol (mg/dL) levels. <h3>Results:</h3> The median age of the 138 patients was 58.3 years with 44 being male (31.9%). Among the 138 patients, 11 (8.0%) died, and 11 (8.0%) and nine (6.5%) had CVA, and ACS, respectively. MHR at diagnosis was significantly correlated with the Birmingham Vasculitis Activity Score, erythrocyte sedimentation rate, and C-reactive protein at diagnosis. Among the three poor outcomes of AAV, only CVA during follow-up was significantly associated with MHR at diagnosis, and thus, only CVA was considered an atherosclerosis-related poor outcome of AAV. In the multivariable Cox hazards model analysis, MHR (hazard ratio [HR] 1.195) and serum albumin (HR 0.203) at diagnosis were independently associated with CVA during follow-up. Additionally, patients with MHR at diagnosis ≥3.0 exhibited a significantly higher risk for CVA and lower cumulative CVA-free survival rate than those with MHR at diagnosis &lt;3.0. <h3>Conclusion:</h3> This study is the first to demonstrate clinical implications of MHR suggesting that MHR at diagnosis is significantly and independently associated with CVA during follow-up in patients with AAV. <h3>REFERENCES:</h3> [1] Jiang M, Yang J, Zou H, Li M, Sun W, Kong X (2022) Monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) and the risk of all-cause and cardiovascular mortality: a nationwide cohort study in the United States. Lipids Health Dis 21(1):30. https://DOI:10.1186/s12944-022-01638-6. [2] Xi J, Men S, Nan J, Yang Q, Dong J (2022) The blood monocyte to high density lipoprotein cholesterol ratio (MHR) is a possible marker of carotid artery plaque. Lipids Health Dis 21(1):130. https://DOI:10.1186/s12944-022-01741-8. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
AB1054 VENOUS THROMBOEMBOLISM (VTE) OUTCOMES IN GENERAL POPULATION COMPARED TO INDIVIDUALS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: INSIGHTS FROM NATIONWIDE INPATIENT SAMPLE 2015-2020
Authors: V. Jelic, S. Piplani, S. T. Kolli, P. K. Komminni, J. Reet, S. R. Goguri, V. R. Bejugam, S. P. Kasire, P. Mogga, N. Tanasijevic, D. Damania, M. Vukelic, M. Radulovic
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Venous thromboembolism (VTE) poses a significant health concern in individuals with SLE. SLE patients exhibit an increased risk of VTE due to inflammation, antiphospholipid antibodies, and other factors. Understanding this association is crucial for effective management and preventive strategies in this vulnerable population. <h3>Objectives:</h3> To examine Venous Thromboembolism (VTE) outcomes in general population compared to individuals with Systemic Lupus Erythematosus. <h3>Methods:</h3> National Inpatient Database was queried from 2015 to 2020, with principal diagnosis of venous thromboembolism and secondary diagnosis was used for SLE using ICD-10 codes. Data was appended using latest HCUP guidelines. Univariate analysis with student t test and chi square was performed, and a multivariate regression model was created to generate odds ratio adjusting for hospital level confounders and various co-morbidities. P-value of &lt;0.05 was considered significant, and all the analysis was performed using STATA-MP v 14.2. <h3>Results:</h3> Among 1,525,844 in the general population and 5,510 with SLE, SLE patients were younger (50.8 vs. 62.8 years), with varying racial distributions. Notably, SLE patients exhibited higher rates of VTE in certain demographics. The Charlson Comorbidity Index (CCI) indicated significant differences, suggesting Lupus patients with lower comorbidity indices had higher VTE rates. Various comorbidities, including CHF, COPD, cancer, obesity, and others, exhibited significantly different prevalence between the two groups with p&lt;0.0001. While univariate analysis showed significant differences in mortality, hospital stay, total charges, and respiratory failure, multivariate analysis revealed non-significant differences in mortality and respiratory failure. Hospital stay and total charges remained significantly different, highlighting the impact of confounding factors on certain outcomes in VTE patients. <h3>Conclusion:</h3> It was found that VTE in SLE is associated with younger age, female gender, and several other distinct demographic and clinical characteristics, reflecting a unique profile compared to the general population. <h3>REFERENCES:</h3> <b>NIL.</b> <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
AB0996 HUMAN PAPILLOMAVIRUS VACCINATION AWARENESS IN CHINESE AUTOIMMUNE INFLAMMATORY RHEUMATIC DISEASES: A LARGE REAL-WORLD SURVEY
Authors: J. Zhao, Z. Zhang
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Women with autoimmune inflammatory rheumatic diseases (AIIRDs) may be more vulnerable to human papillomavirus (HPV) infection and HPV-related cervical cancers [1,2]. However, the HPV test and HPV vaccination rate was low in those patients [3]. <h3>Objectives:</h3> We conducted a real-world survey to evaluate the HPV vaccination awareness and HPV vaccination status in Chinese AIIRDs patients. <h3>Methods:</h3> Female AIIRDs patients with age≥9 years were enrolled. From 1 April 2023 to 31 Aug 2023, eligible participants completed a predefined 47-question-based questionnaire by invitation on social media and visiting the outpatient department. We evaluated the demographics, rheumatic disease history, HPV infection and HPV vaccination awareness, HPV test, HPV vaccination status and HPV vaccination willingness of all the participants and compared the above status between SLE and RA patients. <h3>Results:</h3> 562 participants with age of 34.9 (29.7-42.6) years completed the relevant questionnaires. The disease distribution was demonstrated in Table 1. The awareness rate of HPV and HPV vaccination were 82.0% and 85.9%, respectively. Only 69.2% participants were aware of the increased cervical cancer risk associated with HPV. Only 52.3% patients underwent cervical cancer screening in the past 5 years. The willingness rate of HPV vaccine was 72.2%, however the vaccination rate was only 26.1%. 334 SLE patients and 98 RA patients were enrolled. Comparing to RA patients, the SLE patients were younger, had higher HPV vaccination awareness rate but a low vaccination rate (Table 2). <h3>Conclusion:</h3> Patients with AIIRDs have high awareness rate of HPV infection, HPV vaccination and high willingness of HPV vaccine but low cervical cancer screening rate and HPV vaccination rate. SLE patients have higher awareness rate of HPV vaccination but lower vaccination rate than RA patients. <h3>REFERENCES:</h3> [1] García-Carrasco M, Mendoza-Pinto C, Rojas-Villarraga A, et al. Prevalence of cervical HPV infection in women with systemic lupus erythematosus: A systematic review and meta-analysis. Autoimmun Rev. 2019 Feb;18(2):184-191. [2] Dreyer L, Faurschou M, Mogensen M, Jacobsen S. High incidence of potentially virus-induced malignancies in systemic lupus erythematosus: a long-term followup study in a Danish cohort. Arthritis Rheum. 2011 Oct;63(10):3032-7. [3] Dhar JP, Essenmacher L, Dhar R, Ragina N, Sokol RJ. Lack of Uptake of Prophylactic Human Papilloma Virus Vaccine Among Women With Systemic Lupus Erythematosus Seen at a Regional Medical Center. J Clin Rheumatol. 2019 Dec;25(8):348-350. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
AB0995 ABNORMALITIES OF CIRCULATING CD4+T CELL SUBPOPULATIONS IN PATIENTS WITH LATE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS CLINICAL SIGNIFICANCE
Authors: L. Xue, H. Q. Niu
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> CD4<sup>+</sup>T cell subpopulations play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE). Both numerical and functional disturbances have been reported in patients with adult-onset SLE [1,2], while little is known about their status in untreated late-onset SLE. <h3>Objectives:</h3> To explore the changes and clinical significance of circulating CD4<sup>+</sup>T cell subpopulations in patients with untreated late-onset SLE. <h3>Methods:</h3> Peripheral blood samples and clinical information were collected from 55 patients with late-onset SLE (≥50 years), 195 patients with adult-onset (18-49 years), and 160 healthy controls. All patients were newly diagnosed and untreated. Percentages and absolute numbers of CD4<sup>+</sup> T cell subsets were determined by flow cytometric analysis. <h3>Results:</h3> Patients with late-onset SLE had lower SLEDAI scores than those with adult-onset SLE. The absolute numbers of circulating Treg (CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup>), Th17 (CD4<sup>+</sup>IL-17<sup>+</sup>), Th1 (CD4<sup>+</sup>IFN-γ<sup>+</sup>) and Th2 (CD4<sup>+</sup>IL-4<sup>+</sup>) cells in patients with late-onset SLE were lower than those in age-matched healthy controls, while the percentages of Treg cells in patients with late-onset SLE also decreased significantly. In addition, the ratios of Th17/Treg were higher in late-onset SLE patients than those in age-matched healthy controls. However, the ratios of Th17/Treg were lower in patients with late-onset SLE than those in adult-onset SLE patients. <h3>Conclusion:</h3> Patients with late-onset SLE show the decreased numbers of Treg cells and the immune imbalance of Th17/Treg. However, the imbalance of Th17/Treg in late-onset SLE patients was milder than that in adult-onset SLE patients, which may be associated with lower disease activity. <h3>REFERENCES:</h3> [1] Li H, Boulougoura A, Endo Y, Tsokos GC. Abnormalities of T cells in systemic lupus erythematosus: new insights in pathogenesis and therapeutic strategies. J Autoimmun. 2022; 132:102870. [2] Chen M, Chen X, Wan Q. Altered frequency of Th17 and Treg cells in new-onset systemic lupus erythematosus patients. Eur J Clin Invest. 2018; 48(11):e13012. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
POS1423 ASSOCIATION BETWEEN VASCULAR FDG UPTAKE DURING FOLLOW-UP AND THE DEVELOPMENT OF THORACIC AORTIC ANEURYSMS IN GIANT CELL ARTERITIS
Authors: D. Blockmans, L. Moreel, A. Betrains, S. Vanderschueren, W. Coudyzer, L. Boeckxstaens, K. Van Laere
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Higher total vascular score at diagnosis is associated with a greater yearly increase in thoracic aortic diameters and volume in patients with giant cell arteritis (GCA)[1]. Radiologic and histopathologic vascular abnormalities persist in a subset of treated GCA patients despite clinical remission. <h3>Objectives:</h3> The aim of this study was to evaluate the association between vascular FDG uptake during follow-up and the development of thoracic aortic aneurysms. <h3>Methods:</h3> In this post-hoc analysis, GCA patients who have had FDG PET imaging at diagnosis ≤3 days after initiation of glucocorticoids and during follow-up were included. PET scans were visually scored (0-3) at 7 vascular areas. PET scans were considered positive in case of FDG uptake ≥ grade 2 in any large vessel. Patients underwent CT imaging at diagnosis and yearly thereafter for a maximum of 10 years. <h3>Results:</h3> Eighty-eight repeat PET scans were performed in 52 out of 106 GCA patients, who were included in the original prospective cohort. 55 (63%) PET scans were done at the time of a relapse and 33 (38%) were done while the patient was in remission. Nine out of ten patients with an incident thoracic aortic aneurysm had both a positive PET scan at diagnosis and during follow-up. <h3>Conclusion:</h3> In addition to the intensity and extent of the initial inflammation, ongoing aortic inflammation also may contribute to the development of thoracic aortic aneurysms in GCA. However, this should be confirmed in a large prospective trial with repeat PET scans at predefined time points during follow-up. <h3>REFERENCES:</h3> [1] Moreel L, Coudyzer W, Boeckxstaens L, Betrains A, Molenberghs G, Vanderschueren S, Claus E, Van Laere K, Blockmans D. Association Between Vascular 18F-Fluorodeoxyglucose Uptake at Diagnosis and Change in Aortic Dimensions in Giant Cell Arteritis. <i>Ann Intern Med</i> (2023) 176:1321–1329. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> Daniel Blockmans GSK, Lily, Roche, Roche, Roche, Lien Moreel: None declared, Albrecht Betrains: None declared, Steven Vanderschueren: None declared, Walter Coudyzer: None declared, Lennert Boeckxstaens: None declared, Koen Van Laere: None declared.
AB0603 IMPACT OF BODY MASS INDEX VARIATION ON DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS
Authors: A. Fazaa, F. Rouatbi, S. Miladi, H. Boussaa, Y. Makhlouf, K. Ben Abdelghani, A. Laatar
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Obesity is a frequent comorbidity in rheumatoid arthritis (RA) that can affect therapeutic efficacy. <h3>Objectives:</h3> The aim of this study was to assess the impact of variations in body mass index (BMI) on RA activity. <h3>Methods:</h3> This is a prospective, monocentric study of patients with RA (ACR/EULAR 2010 criteria) who fasted during the month of Ramadan in 2021. Changes in BMI and disease activity parameters, including number of nocturnal awakenings, number of swollen and painful joints, the global assessment of the disease, erythrocyte sedimentation rate (ESR) and Disease Activity Score 28 based on ESR (DAS28-ESR), were determined during two visits: A first visit before fasting (T1) and a second visit after fasting (T2). The difference (Δ) was calculated between T1 and T2. In all statistical tests, the p significance level was set at 0.05. <h3>Results:</h3> Seventy-two patients, including 13 men and 59 women, with a mean age of 57.8±10.8 years were included. The mean duration of the disease was 11.3 ± 6.6 years. RA was immunopositive in 86% of cases and erosive in 89%. A statistically significant reduction in mean BMI was observed between T1 and T2: 28.1 ± 5.6 (T1) versus 27.6 ± 5.7 kg/m2 (T2) (p=0.001). A significantly positive correlation was found between the decrease in BMI and the decrease in the number of nocturnal awakenings (Δ=-0.3; p&lt;0.05; r=0.234) as well as with the decrease in the number of swollen joints (Δ=-0.3; p=0.05; r= 0.210). No correlation was found between the decrease in BMI and the change in the DAS 28 ESR score (p=0.221), the number of painful joints (p=0.174), the global assessment of the disease (p=0.118) and the ESR rate (p=0.591). <h3>Conclusion:</h3> In agreement with the literature, our study illustrates the impact of a reduction in BMI on certain parameters of disease activity. As a result, integrating weight loss into the therapeutic objectives of the overall management of RA could improve the disease progression. <h3>REFERENCES:</h3> <b>NIL.</b> <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
AB0972 FREQUENCY OF SARCOPENIA IN PATIENTS WITH ANKYLOSING SPONDYLITIS, ITS ASSOCIATION WITH DISEASE COURSE AND PHYSICAL FUNCTION
Authors: Y. Seheda, S. Shevchuk, S. Seheda, I. Kuvikova, A. Boienko
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> During last years association between autoimmune inflammation and early development of sarcopenia was reported in many autoimmune diseases. Ankylosing spondylitis (AkS) is also an autoimmune disorder, which is characterized by predominant skeletal involvement and as a result of this decrease of physical activity. Nevertheless, the role of autoimmunity and disease course in the development of muscle injuries and sarcopenia in AkS patients is still unknown. <h3>Objectives:</h3> The objectives of this study were to estimate prevalence of sarcopenia in AkS patients compared to healthy controls and to investigate the association of low muscle quality with disease course and physical function in AkS patients and healthy subjects. <h3>Methods:</h3> The 35 men with AkS (mean age 38,9±8,99 years, mean disease duration 11,4±6,05 years, mean BMI 22,7±3,09 kg) and 29 age and sex matched healthy controls were included this cross-sectional study. Muscle function was measured with handgrip strength test and short physical performance battery tests (SPPB). Body composition status was measured by dual-energy X-ray absorbtiometry (DXA). Diagnose of sarcopenia, cut-off point of low muscle quality and physical function for handgrip strength (&lt;27 kg) and SBBP-test (&lt;8.0 points) were according to the EWGSOP2 Sarcopenia criteria (2019). The course of disease was evaluated according to BASDAI, ASDAS, BASFI indexes. Statistical analysis was conducted with a t-test for mean difference, and linear regression was used to adjust confounders (age, disease duration, physical exercise, and BMI). <h3>Results:</h3> The subjects' mean muscle strength by handgrip strength tests was 36,3±15,63 kg in AkS patients compared to 41.3±16,7 kg in healthy controls. Low muscle strenghs was found in 45,7% AkS patients (n = 16) and in 17,2% (n= 5) healthy controls. Sarcopenia was diagnosed in 31,1% (n= 11) of AkS patients and only in 10,3% (n=3) healthy controls. The subjects' mean SBPP test score was 9,2±1,75 in main group compared to 11.7± 0,84 in controls. The difference of disease activity in subjects with normal and low muscle strength was found to be significant. Thus the lower muscle strength significantly associated with BASDAI, ASDAS and BASFI indexes and disease duration (p &lt; 0.005) but not associated with age, physical exercise level and BMI (p &lt; 0.005). <h3>Conclusion:</h3> We see more often prevelance of sarcopenia in patients with AkS than in general population. The higher disease activity and prolong disease duration could be the probable risk factors of low muscle mass and function in this patients. <h3>REFERENCES:</h3> <b>NIL.</b> <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
AB0707 PREVALENCE OF NEUROPATHIC PAIN IN RHEUMATOID ARTHRITIS
Authors: S. Bouden, S. Ben Massoud, S. Mhamdi, L. Rouached, A. Ben Tekaya, I. Mahmoud, R. Tekaya, O. Saidane, L. Abdelmoula
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Rheumatoid arthritis (RA) is a chronic inflammatory rheumatism often leading to a progressive deterioration in the quality of life of patients mainly due to pain. The neuropathic component has recently been recognized as an important aspect of this pain. <h3>Objectives:</h3> To determine the frequency of neuropathic pain (NP) in patients with RA, and its associated factors. <h3>Methods:</h3> A single-center cross-sectional study was carried out in the rheumatology department of Charles Nicole Hospital. Patients diagnosed with RA according to the ACR/EULAR 2010 criteria were included. Pain was measured using the visual analog scale (VAS), while the neuropathic component was detected using the DN4 and PAIN-DETECT scores. <h3>Results:</h3> Our study included 121 patients. The average age was 40±10 years. 83.3% (n=106) were female. Concerning the therapeutic aspect, 69.9% were treated by MTX and 53.7% were treated by biologics. For symptomatic treatment, 93.4% were under analgesics, 76% were on corticosteroid therapy and 24.8% were under NSAIDs. According to the DN4 score, NP was present in 74 of the cases (61.2%); and according to the PAIN-DETECT score, 57 (47.1%) were categorized as likely NP, 33 (27.3%) were categorized as possible NP, and 31 (25.6%) were categorized as unlikely NP. A positive correlation was observed between the presence of NP detected by the DN4 score and the following parameters: the pain VAS (p=0.01), the CRP level (p=0.007) and the DAS28 value (p=0.04). <h3>Conclusion:</h3> In our study, NP was significantly associated with activity parameters of RA. Consideration of the neuropathic component is of significant importance in the context of pain associated with RA. <h3>REFERENCES:</h3> <b>NIL.</b> <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
AB0989 CHATGPT4’S PROFICIENCY IN ADDRESSING PATIENTS’ QUESTIONS ON SYSTEMIC LUPUS ERYTHEMATOSUS: A BLINDED COMPARATIVE STUDY WITH SPECIALISTS
Authors: R. Mu, C. Xu, D. Xu, J. Zhao, R. Liu, Y. Dai, K. Sun, P. Wong, S. S. M. Lee, L. W. Koh, J. Wang, S. Xie, L. Zeng
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Artificial intelligence (AI)-driven chatbots like ChatGPT are gaining recognition for their healthcare applications, yet the efficacy of ChatGPT4 in specialized medical consultations remains underexplored, particularly in rheumatology. <h3>Objectives:</h3> This study compares the proficiency of ChatGPT4' responses with practicing rheumatologists to inquiries from patients with systemic lupus erythematosus (SLE). <h3>Methods:</h3> In this cross-sectional study, 95 frequently asked questions (FAQs) were curated from the Kidney Online platform (www.shensx.com). Responses for FAQs from ChatGPT4 and 5 rheumatologists were generated and then scored separately by a panel of rheumatologists and a group of patients with SLE. Responses were scored across 6 domains (scientific validity, logical consistency, comprehensibility, completeness, satisfaction level, and empathy) on a 0-10 scale (a score of 0 indicates entirely incorrect responses, while 10 indicates accurate and comprehensive answers). <h3>Results:</h3> Rheumatologists' scoring revealed that ChatGPT4-generated responses outperformed those from rheumatologists in satisfaction level and empathy, with mean differences of 0.542 (95% CI, 0.258 to 0.827; <i>P&lt;</i>0.01) and 0.453 (95% CI, 0.221 to 0.685; <i>P</i>&lt;0.01), respectively (Figure 1). No significant differences were observed in scientific validity, logical consistency, comprehensibility or completeness (Figure 1). From the SLE patients' perspective, ChatGPT4-generated responses were comparable with the rheumatologist-provided answers in all 6 domains (Figure 2). <h3>Conclusion:</h3> ChatGPT4 demonstrated comparable, possibly better in certain domains, to address the FAQs from patients with SLE, when compared with the answers provided by specialists. This study showed the potential of applying ChatGPT4 to improve the consultation in rheumatology. <h3>REFERENCES:</h3> <b>NIL.</b> <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>