tbuckley/cabot-search huggingface dataset:
The Relationship of Pain to Jaundice
Authors: James F. Weir, Wallace T. Partch
Journal: Annals of Internal Medicine (1931)

Article1 June 1931The Relationship of Pain to JaundiceJAMES F. WEIR, M.D., WALLACE T. PARTCH, M.D.JAMES F. WEIR, M.D.Search for more papers by this author, WALLACE T. PARTCH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-12-1509 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the last decade certain adjustments have been made in our conception of jaundice. This has been due largely to the application by van den Bergh of Ehrlich's diazo reagent to the blood serum and to the demonstration by Mann and his associates, and others, that bilirubin forms chiefly outside the liver and that the polygonal hepatic cell is the normal pathway of excretion of bilirubin. Jaundice may be produced in one of three ways: obstruction of the biliary passages, increased production of bilirubin beyond the ability of the liver to excrete it, or functional derangement of the polygonal hepatic...Bibliography1 BOLLMAN JL: Peptic ulcer in experimental obstructive jaundice. Proc. Staff Meetings of Mayo Clinic, 5:357-358 (Dec. 10) 1930. Google Scholar2 EUSTERMAN GB: Carcinoma of the pancreas: A clinical study of 138 cases. Tr. Am. Gastro-Enterol. Assn. 126-135, 1922. Google Scholar3 GRAHAMCOLECOPHERMOORE EAWHGHS: Diseases of the gallbladder and bile ducts. Philadelphia, Lea and Febiger, 1928, 477 pp. Google Scholar4 HARTMAN HR: Jaundice in surgical cholecystitis without stones. Med. Clin. N. Amer. 7:89-95 (July) 1923. Google Scholar5 JUDD ES: Stricture of the common bile duct. Ann. Surg. 84:404-410 (Sept.) 1926. CrossrefMedlineGoogle Scholar6 JUDDMCINDOE ESA: Cholangitis. Jour. Michigan State Med. Soc. 29:174-179 (March) 1930. Google Scholar7 JUDDWHITE ESRB: Prolonged drainage of the common duct. Tr. South. Surg. and Gynec. Assn. 41:159-167, 1928. Google Scholar8 MANNSHEARDBOLLMANBALDES FCCJLEJ: The site of the formation of bilirubin. Am. Jour. Physiol. 74:497-510 (Nov.) 1925. CrossrefGoogle Scholar9 MCNEE JW: Jaundice: A review of recent work. Quart. Jour. Med. 16:390-420 (July) 1923. CrossrefGoogle Scholar10 MCVICARFITTS CSWT: Clinical aspects of jaundice. Jour. Am. Med. Assn. 89:2018-2021 (Dec. 10) 1927. CrossrefGoogle Scholar11 MUSSEY RD: Pancreatic carcinoma. Med. Clin. N. Amer. 3:681-688 (Nov.) 1919. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Medicine The Mayo Clinic Rochester, MinnesotaWelborn Hospital Clinic Evansville, Indiana*Submitted for publication February 11, 1931.**Work done while a Fellow in Medicine, The Mayo Foundation, Rochester, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1931Volume 4, Issue 12Page: 1509-1520KeywordsBilirubinBlood cellsExcretionHepatocytesLiver ePublished: 1 December 2008 Issue Published: 1 June 1931 PDF downloadLoading ...
Defects of the Mismatch Repair Gene MSH2 Are Implicated in the Development of Murine and Human Lymphoblastic Lymphomas and Are Associated With the Aberrant Expression of Rhombotin-2 (Lmo-2) and Tal-1 (SCL)
Authors: Robert Lowsky, John F. DeCoteau, Armin H. Reitmair, Ryo Ichinohasama, Wei-Feng Dong, Yi Xu, Tak W. Mak, Marshall E. Kadin, Mark D. Minden
Journal: Blood (1997)
Our Changing Profession
Authors: Thomas B. Cooley
Journal: Annals of Internal Medicine (1929)

Article1 January 1929Our Changing ProfessionTHOMAS B. COOLEYTHOMAS B. COOLEYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-7-685 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThese somewhat random thoughts are the result of cogitation over a questionaire from the Council on Medical Education, which I daresay some of you also received, and to answer which satisfactorily would involve consideration of the history and development of medicine, the past and present status of the medical profession, in itself and in relation to the community, and possible changes due on the one hand to the advance of science, and on the other to developments in the general social structure.It is the veriest commonplace to say that there has been, within the past quarter century, a very... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Presidential address, Detroit Academy of Medicine, 1927. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChoosing the Student Body: Masculinity, Culture, and the Crisis of Medical School Admissions, 1920–1950 1 January 1929Volume 2, Issue 7Page: 685-688KeywordsHistory of medicineMedical education ePublished: 1 December 2008 Issue Published: 1 January 1929 PDF downloadLoading ...
Rosacea
Authors: Frank C. Powell
Journal: New England Journal of Medicine (2005)

A 47-year-old white woman reports facial redness and flushing. Her eyes are itchy and irritated. She thinks she may have rosacea and is worried that she will have a "whiskey nose." On examination, multiple erythematous papules, pustules, and telangiectasias are observed on a background of erythema of the central portion of her face. How should her case be managed?
Abstract 10237: Interleukin-1 Receptor-associated Kinase 3 (IRAK3) is a Potential Monocyte-related Link between Inflammation and Oxidative Stress in Obesity and Atherosclerosis
Authors: Maarten Hulsmans, Benjamine Geeraert, Dieuwke De Keyzer, Paul Holvoet
Journal: Circulation (2010)
Abstract 12271: Association of Sex Hormone Status with Circulating Natriuretic Peptides
Authors: Carolyn S Lam, Susan Cheng, Andrea D Coviello, Martin G Larson, Joanne M Murabito, Christopher Newton-Cheh, Shalender Bhasin, Elizabeth L McCabe, Karen K Miller, Margaret M Redfield, Ramachandran S Vasan, Thomas J Wang
Journal: Circulation (2010)
Insurance practice inhibits GPs exploring the sexual behaviour of patients
Authors: P. Thornton
Journal: BMJ (1996)

when abnormalities had been reported by patients-that is, lumpy semen (cells and spermatozoa around eggs), semen that was more fluid than usual, blood in the semen, or discoloration of the semen.Often this group of travellers has been exposed to potentially infected waters in a range of coun- tries in Africa.The references cited by P Jordan and G Webbe attest to the longstanding focus of infection in Lake Malawi.Our point in emphasising the occurrence of infection among those exposed only in this lake was to indicate that travellers are often not aware of this risk.
Abstract 11312: Psychosocial Factors Influencing Mental Health in Adults with Congenital Heart Disease in Japan
Authors: Junko Enomoto, Jun Nakazawa, Yoshiko Mizuno, Takeaki Shirai, Junko Ogawa, Koichiro Niwa
Journal: Circulation (2011)

Background: Adults with congenital heart disease (ACHD) patients face unique social challenges that are related to psychosocial adjustment and mental health. Despite this, studies specifically examining psychosocial issues and the mental health of ACHD patients are few in Japan and we do not have any knowledge about the psychosocial mechanism related to the mental health of patients. The aim of this study was (1) to compare the psychosocial aspects of ACHD with that of a control group, (2) to determine psychosocial factors influencing the mental health of patients. Method: Seventy-two ACHD patients (aged 18-39 years; 57% male) and 86 control participants (aged 18-39 years; 48% male) completed SF36 which measures mental health and self-report questionnaires composed of 4 psychosocial measures including Independency-dependency on parents, Social problem solving, Locus of control and Self-esteem. Result: ANOVAs (sex ×ACHD•control) revealed that patients showed significantly lower scores in “ Independence”, “...
Selective Anti Leukemic Activity Of Low Dose Decitabine In Combination With Ruxolitinib Against Stem/Progenitor Cells From Elderly AML Patients
Authors: Cedric Dos Santos, Puneet Agarwal, McDonald Tinisha, Allen Lin, Stephen J. Forman, Ya-Huei Kuo, Ravi Bhatia
Journal: Blood (2013)
Abstract 10538: Endogenous Prostacyclin Inhibitor Coupling Factor 6 Enhances Spontaneous Platelet Micro-Aggregation in Patients with Recent Onset Stroke Independently of Anti-Platelet Therapy
Authors: Takanori Sukekawa, Tomohiro Osanai, Akiko Suzuki, Tomohide Endo, Shunta Tateyama, Fumie Nishizaki, Yuko Yamamoto, Kei Izumiyama, Shigeki Sagara, Norifumi Metoki, Joji Hagii, Satoko Sasaki, Takaatsu Kamada, Yoshiyuki Konta, Ken Okumura
Journal: Circulation (2011)

Backgrounds: Spontaneous platelet micro-aggregation is a marker for the prognosis of patients with cardiovascular diseases. Coupling factor 6 (CF6) is a pro-atherogenic molecule, and functions afte...
The usefulness of contrast-enhanced ultrasonography in the early detection of hepatocellular carcinoma viability after transarterial chemoembolization: pilot study
Authors: Youn Zoo Cho, So Yeon Park, Eun Hee Choi, Soon Koo Baik, Sang Ok Kwon, Young Ju Kim, Seung Hwan Cha, Moon Young Kim
Journal: Clinical and Molecular Hepatology (2015)

Background/Aims The therapeutic effect of transarterial chemoembolization (TACE) against hepatocellular carcinoma (HCC) is usually assessed using multidetector computed tomography (MDCT). However, dense lipiodol depositions can mask the enhancement of viable HCC tissue in MDCT. Contrast-enhanced ultrasonography (CEUS) could be effective in detecting small areas of viability and patency in vessels. We investigated whether arterial enhancement in CEUS after treatment with TACE can be used to detect HCC viability earlier than when using MDCT. Methods Twelve patients received CEUS, MDCT, and gadoxetic-acid-enhanced dynamic magnetic resonance imaging (MRI) at baseline and 4 and 12 weeks after TACE. The definition of viable HCC was defined as MRI positivity after 4 or 12 weeks. Results Eight of the 12 patients showed MRI positivity at 4 or 12 weeks. All patients with positive CEUS findings at 4 weeks (n=8) showed MRI positivity and residual viable HCC at 4 or 12 weeks. Five of the eight patients with positive CEUS findings at 4 weeks had negative results on the 4-week MDCT scan. Four (50%) of these eight patients did not have MRI positivity at 4 weeks and were ultimately confirmed as having residual HCC tissue at the 12-week MRI. Kappa statistics revealed near-perfect agreement between CEUS and MRI (κ=1.00) and substantial agreement between MDCT and MRI (κ=0.67). Conclusions In the assessment of the response to TACE, CEUS at 4 weeks showed excellent results for detecting residual viable HCC, which suggests that CEUS can be used as an early additive diagnosis tool when deciding early additional treatment with TACE. Keywords: Hepatocellular carcinoma; Transarterial chemoembolization; Contrast-enhanced ultrasonography; Computed tomography; Magnetic resonance imaging
Abstract 4348: Additive Value of Interventricular Mechanical Delay to Intraventricular Dyssynchrony for Predicting Response to Cardiac Resynchronization Therapy
Authors: Hideyuki Hara, Olusegun Oyenuga, Hidekazu Tanaka, Han-Na Kim, Samir Saba, John Gorcsan
Journal: Circulation (2008)

Echocardiographic measures of dyssynchrony have typically been used individually to predict response to cardiac resynchronization therapy (CRT). Our objective was to test the hypothesis that the ad...
Abstract 15319: Thioredoxin Interacting Protein Interacts with Protein Disulfide Isomerases and increases Endoplasmic Reticulum Stress
Authors: Samuel Lee, William A Chutkow, Parth Patwari, Edward P Feener, Richard T Lee
Journal: Circulation (2011)

Introduction: The alpha arrestin Thioredoxin interacting protein (Txnip) is an inhibitor of the antioxidant thioredoxin and regulates the endothelial response to shear stress as well as metabolism ...
Abstract 12986: Is Beta3-Adrenoceptor (AR) a Target for Heart Failure Therapy? Evidence From Beta3-AR Knockout Mice
Authors: Che Ping Cheng, Heng-Jie Cheng, Peng Zhou, Satoshi Masutani, Michael F Callahan, J M Cline, William C Little
Journal: Circulation (2011)

Background. Heart failure (HF) is associated with the upregulation of β3-adrenergic-receptor (AR)-mediated cardiac inhibitory pathway. This suggests cardiac β3-AR activation may contribute to HF pr...
Abstract 2425: MR Imaging of Atherosclerotic Lesions in Rabbit Aortas Using Gadofosveset
Authors: Marc Lobbes, Sylvia Heeneman, Robbert-Jan Miserus, Tim Leiner, Fons Kessels, Andrea Wiethoff, Mat Daemen, Jos van Engelshoven, M. Eline Kooi
Journal: Circulation (2006)

Introduction: MS-325 (Vasovist®, Schering AG, Germany) is an albumin-binding contrast agent. We hypothesized that MS-325 can be used as a contrast agent to detect atherosclerotic lesions in rabbit ...
Effects in Rats of Sodium Chloride on Experimental Gastric Cancers Induced by N-Methyl-N′-nitro-N-nitrosoguanidine or 4-Nitroquinoline-1-oxide2
Authors: Masae Tatematsu, Michihito Takahashi, Shoji Fukushima, Motoo Hananouchi, Tomoyuki Shirai
Journal: JNCI Journal of the National Cancer Institute (1975)

The effects were studied of NaCl on the production of gastric carcinomas by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and by 4-nitroquinoline-1-oxide (NQO) in male Wistar rats. Nine groups of rats were treated as follows: Group 1 was given 50 mg MNNG/liter and 6 g NaCl solution/liter to drink and was fed a stock diet supplemented with 10% NaCl. Group 2 received 1 ml saturated NaCl once a week and 50 mg MNNG/liter to drink. Group 3 was treated with MNNG alone. Group 4 was given a solution of 1 mg NQO once a week and fed a stock diet supplemented with 10% NaCl. Group 5 received a solution of 1 mg NQO saturated with NaCl. Group 6 was given NQO alone. Groups 7 and 8 were given NaCl alone. Group 9 was untreated. Adenocarcinomas developed in the glandular stomach in group 2 at a significantly higher incidence than in group 3. Poorly differentiated adenocarcinomas of the glandular stomach were detected in only groups 1 and 2. One poorly differentiated adenocarcinoma metastasized to the lymph nodes. A high incidence of squamous cell carcinomas of the forestomach was found in groups 4 and 5. No malignant tumors were seen in groups 6-9. NaCl given alone had no apparent carcinogenicity in rats but, when administered with MNNG or NQO, it enhanced the carcinogenic effects of MNNG and NQO in the stomach.
Abstract 206: Utilization and Outcome of Therapeutic Hypothermia for Out-of-Hospital Cardiac Arrest
Authors: Awani Deshmukh, Achint Patel, Nileshkumar Patel, Abhishek Deshmukh, Neil Patel, Avirup Guha, Grishma Dhaduk, Sadip Pant, Shantanu Solanki, Sohilkumar Manvar, Shilpkumar Arora, Nilay Patel, Vinaykumar Panchal, Badal Thakkar, Apurva Badheka, Hakan Paydak, Manish Joshi
Journal: Circulation (2014)

Background:  Therapeutic hypothermia (TH) is recommended in international resuscitation guidelines.TH has been incorporated into the American Heart Association practice guidelines and use of TH has steadily increased, but widespread clinical uptake remains low   Hypothesis:  Our aim was to examine the frequency of TH use after cardiac arrest in United States.   Methods:  We analyzed data from years 2004-2011 from the United States Nationwide Inpatient Sample which is the largest hospitalization database available in United States. Using International Classification of Diseases-9 (ICD-9) codes, we identified cases with cardiac arrest (427.5) who underwent therapeutic hypothermia (99.81). Population estimates were obtained by complex sample analysis used for NIS design.   Results:  The utilization of TH in OHCA has significantly increased from 0.06% in 2004 to 6.43 % in 2011. The TH was utilized more in men (53.5%), age group 65-79 years (35.0%), white ( 59.3% ) , private insurance ( 52.8% ) , charlsons comorbidity index >=2 ( 88.2% ) , hospitals located in urban (91.6%) teaching hospitals ( 58.4% ) , hospitals on the West coast ( 28.1% ) , large bed hospitals ( 72.9% ) . The adjusted odds ratio for hospital mortality among patients undergoing TH was 1.6 (95% CI 1.05-2.52, p=0.027). Number of hospitals performing TH has increased from 2004(0.07%) to 2011(6.31%).   Conclusion:  TH utilization appears low but implementation is increasing. Case selection and referral biases limit the analysis of the relationship between center TH volume and in hospital mortality.
Abstract 13627: Long-term Clinical Efficacy of Endovascular Therapy for Patients with Critical Limb Ischemia due to Pure Isolated Infrapopliteal Lesions
Authors: Osamu Iida, Yoshimitsu Soga, Yasutaka Yamauchi, Keisuke Hirano, Daizo Kawasaki, Junichi Tazaki, Terutoshi Yamaoka, Nobuhiro Suematsu, Kenji Suzuki, Yoshiaki Shintani, Yusuke Miyashita, Masaaki Uematsu
Journal: Circulation (2012)

Background: The prognostic outcomes of endovascular therapy (EVT) for isolated infrapopliteal lesions remain to be adequately studied. Objectives: We investigated and risk-stratified long-term prog...
CONGENITAL DILATATION OF THE PULMONARY ARTERIES REVEALED BY ROENTGENKYMOGRAPHY
Authors: Sydney E. Johnson
Journal: Annals of Internal Medicine (1936)

Case Reports1 October 1936CONGENITAL DILATATION OF THE PULMONARY ARTERIES REVEALED BY ROENTGENKYMOGRAPHYSYDNEY E. JOHNSON, M.D., F.A.C.P.SYDNEY E. JOHNSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-4-546 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRoentgenkymography is so new an addition to the diagnostic procedures of roentgenology that few physicians in general practice are aware of its value and diagnostic indications. The writer is of the opinion that the method has a wide field of usefulness and that it will come into general use in radiological practice as soon as its various applications are more generally known.Roentgenkymography differs from other roentgenographic methods in that its single function is to record movement (and negatively, the absence of movement in organs or parts of the body that normally have movement). With this method it is possible...References1. STUMPF P: Das roentgenographische Bewegungsbild, Fortschr. a. d. Geb. d. Röntgenstr., 1931, xxxviii, 6. Google Scholar2. HIRSCH IS: The recording of cardiac movements and sounds by the roentgen-ray, Radiology, 1934, xxii, 403-422. CrossrefGoogle Scholar3. JOHNSON SE: The roentgenkymograph as a new aid in the diagnosis of adhesive pericarditis, Surg., Gynec. and Obst., 1935, lxi, 169-174. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisville, Kentucky*Received for publication April 23, 1936. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBenign Infundibular Pulmonary Stenosis with Secondary Dilatation of the Main Pulmonary Artery 1 October 1936Volume 10, Issue 4Page: 546-549KeywordsPrimary carePulmonary arteries ePublished: 1 December 2008 Issue Published: 1 October 1936 PDF downloadLoading ...
Abstract 16243: Beta-Blocker Therapy Reduce Threshold for Exercise Induced Ventricular Arrhythmias in Patients with CPVT
Authors: Kristina H Haugaa, Ida S Leren, Knut Erik Berge, Jorn Bathen, Jan Pal Loennechen, Ole-Gunnar Anfinsen, Andreas Fruh, Thor Edvardsen, Erik Kongsgard, Trond p Leren, Jan p Amlie
Journal: Circulation (2010)

Introduction: Catecolaminergic polymorphic ventricular tachycardia (CPVT) is an inherited cardiac disease which predisposes to exercise-induced life-threatening arrhythmias. The current therapeutic...
Fitness programme for chronic low back pain
Authors: M Williams
Journal: BMJ (1995)

has allowed safe and easy access to the upper gastrointestinal tract for feeding.These systems have almost entirely replaced surgical gastrostomy procedures.3A double channel valve allows separate ports for feeding and stomach drainage.Various kits are now available.Short term follow up studies have shown reduced mortality and morbidity in patients who have had an endoscopic gastrostomy compared with those who have had a surgical gastrostomy, but long term follow up data are limited.4Severe gastroparesis diabeticorum has a high mortality.'This treatment allowed our patient to go home for considerably longer than he had managed previously, and we consider that per- cutaneous endoscopic gastrojejunostomy feeding is a useful therapeutic option in gatroparesis diabeticorum that has not responded to standard medical management.
Abstract 16622: Frailty Predicts Outcomes in Elderly Patients Undergoing Cardiac Surgery
Authors: Chris P Childers, S. C Malaisrie, Patrick M McCarthy, Attapoom Susupaus, Adin-Cristian Andrei, Brittany Lapin, Lee Lindquist, Richard Lee, Edwin C McGee, Kathleen L Grady
Journal: Circulation (2011)

Background: Preoperative composite frailty measures have been shown to predict a multitude of postoperative outcomes in general surgical patients but there is little data on their predictive capacity on cardiac surgery (CS) outcomes. The aim of this study was to evaluate the predictive ability of a composite assessment of frailty in CS practice. Methods: From April 2009 to April 2011, 1657 patients underwent CS at a single-center, tertiary-care hospital. Of these, 836 patients were ≥ 65 years of age and baseline frailty data were available on a convenience sample of 136. Operations included 20 (15%) isolated CABG, 31 (23%) isolated valve, and 85 (62%) combination and other-cardiac procedures. Frailty status was classified using modified Fried criteria including (1) unintentional weight loss, (2) weakness (grip strength), (3) exhaustion (SF 36 vitality subscale), (4) slowness (walking time, 15 feet), and (5) low activity (SF 36 physical function subscale). Of the 136, 17 (13%) patients met 3 or more criter...
Study overestimates depression due to victimisation in adolescence
Authors: Mike A Males
Journal: BMJ (2015)

Bowes and colleagues overstate the amount of adult depression associated with peer bullying in adolescence because of serious limitations in their dataset1—for example, failure to control for confounding by previous adult bullying in childhood. Adult violence and bullying against children and adolescents is widespread. In the US, authorities substantiated 120 000 physical abuses, …
Abstract 20644: Comparison of Efficacy and Safety of First-line Transplacental Treatment of Fetal Supraventricular Tachycardia (SVT) and Atrial Flutter (AF) with Sotalol, Flecainide and Digoxin
Authors: Edgar T Jaeggi, Julene S Carvalho, Ernestine De Groot, Olus Api, Sally-Ann Clur, Cedric Manlhiot, Brian W McCrindle, Lukas Rammeloo, Nico A Blom
Journal: Circulation (2010)

Background: Fetal tachyarrhythmias may result in low cardiac output and death. Consequently, treatment is offered to most affected pregnancies. We compared 3 commonly used drugs in controlling feta...