SOME OBSERVATIONS ON MERCURIAL DIURETICS
Authors: J. Hamilton Crawford, W. S. Mcdaniel
Journal: Annals of Internal Medicine (1935)

Article1 April 1935SOME OBSERVATIONS ON MERCURIAL DIURETICSJ. HAMILTON CRAWFORD, M.D., F.A.C.P., W. S. MCDANIEL, M.D.J. HAMILTON CRAWFORD, M.D., F.A.C.P.Search for more papers by this author, W. S. MCDANIEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-10-1266 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe use of mercury as a diuretic was advocated first by Jendrassik1in 1886. He administered frequent small doses of calomel by mouth and by this means obtained in many cases a marked increase in urine volume. Gradually this form of treatment fell into more or less disuse as observers reported deleterious effects as a result of the mercury absorbed. In recent years, following the introduction of the complex organic compound of mercury, novasurol, first described by Saxl and Heilig2in 1920, mercury has again assumed a prominent place in the treatment of edematous conditions. The favorable results which the...References1. JENDRÁSSIK E: Das Calomel als Diureticum, Deutsch. Arch. f. klin. Med., 1886, xxxviii, 499-524. Google Scholar2. SAXLHEILIG PR: Über die diuretische Wirkung von Novasurol und anderen Quecksilberinjektionen, Wien. klin. Wchnschr., 1920, xxxiii, 943. Google Scholar3. BINGERKEITH MWNM: Effect of diuretics in different types of edema, Jr. Am. Med. Assoc., 1933, ci, 2009-2016. CrossrefGoogle Scholar4. SCHMITZ HL: Studies on action of diuretics; effect of euphyllin and salyrgan upon glomerular filtration and tubular reabsorption, Jr. Clin. Invest., 1932, xi, 1075-1097. CrossrefGoogle Scholar5. KEITHBARRIERWHELAN NMCWM: Diuretic action of ammonium chloride and novasurol in cases of nephritis with edema, Jr. Am. Med. 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Google Scholar13. SPENGLER G: Zur Therapie der Leberzirrhose, Wien. klin. Wchnschr., 1931, xliv, 257-259. Google Scholar14. PRATSIKAS A: Das Quecksilber-Diuretikum "Novurit" in der Klinik, Wien. med. Wchnschr., 1933, lxxxiii, 28-30. Google Scholar15. CRAWFORDMCINTOSH JHJF: Use of novasurol in edema due to heart failure, Jr. Clin. Invest., 1925, i, 333-358. CrossrefGoogle Scholar16. SCHMITZ HL: Studies on action of diuretics; effect of salyrgan upon water content of plasma as measured by refractive index, Jr. Clin. Invest., 1933, xii, 741-750. CrossrefGoogle Scholar17. LASSEN HC: Studies on kidney function after Rehberg method; variations of filtration in normal adults, Acta med. Scandinav., 1932, lxxix, 275-297. Google Scholar18. LASSEN HC: Some investigations on kidney function in heart lesions, Acta med. Scandinav., 1932, Suppl. 50, 216-413. Google Scholar19. BARTRAM EA: Experimental observations on effect of various diuretics when injected directly into one renal artery of dog, Jr. Clin. Invest., 1932, xi, 1197-1219. CrossrefGoogle Scholar20. DAVENPORTFULTONVAN AUKENPARSONS LFMNHARJ: Creatinine clearance as measure of glomerular filtration in dogs with particular reference to effect of diuretic drugs, Am. Jr. Physiol., 1934, cviii, 99-106. CrossrefGoogle Scholar21. BLUMGARTGILLIGANLEVYBROWNVOLK HLDRRCMGMC: Action of diuretics. I. Action of diuretics in normal persons, Arch. Int. Med., 1934, liv, 40-81. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Received for publication July 23, 1934.From the Department of Cardiology, Kings County Hospital, and the Department of Physiology and Pharmacology of the Long Island College of Medicine.†Originally introduced as Novurit, this drug is sold in America under the name of Mercupurin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA History of DiureticsApproaches to Diuretic Therapy and Electrolyte Imbalance in Congestive Heart FailureClinical trials of diuretic therapy in heart failure: Research directions and clinical considerationsThe use of mercupurin in the treatment of congestive heart failure and in the mobilization of excess body fluid 1 April 1935Volume 8, Issue 10Page: 1266-1273KeywordsDiureticsDrugsHospital medicineMouthPharmacologyUrine ePublished: 1 December 2008 Issue Published: 1 April 1935 PDF downloadLoading ...