tbuckley/cabot-search huggingface dataset:
A systematic, updated review of Xuezhikang, a domestically developed lipid-lowering drug, in the application of cardiovascular diseases
Authors: Cheng Yang, Yongjian Wu, Jie Qian, Jian-Jun Li
Journal: Acta Pharmaceutica Sinica B (2024)

Cardiovascular diseases (CVDs) are a major threat to public health globally. A large proportion of people with dyslipidaemia have poorly controlled lipid levels, emphasizing the need for alternative lipid-lowering treatments that are both effective and safe. Xuezhikang, a red yeast rice (RYR) extract, containing 13 kinds of monacolins and other bioactive components, emerges as one such promising option. Its discovery was built on a long history of RYR use as a functional food supplement and traditional Chinese medicine. Several randomized, controlled clinical trials have substantiated its lipid-lowering effects and its potential to protect against CVDs. Safety concerns with statins did not arise during decades of experience with Xuezhikang treatment in clinical practice. The approval of Xuezhikang in multiple regions of Asia marked a conceptual shift in CVD management, moving from single agents to polypills and from synthetic medicines to natural extracts. This review comprehensively addresses important topics related to this medicinal natural extract, including the ancient utilization of RYR, the development of Xuezhikang, its mechanisms of action, pleiotropic effects, clinical studies, challenges, and future perspectives to enhance our understanding regarding the role of Xuezhikang, a representative, domestic lipid-lowering drug of RYR, in prevention and treatment of CVD.
Letter to the Editor: a commentary on “impact of immediate postrecanalization cooling on outcome in acute ischemic stroke patients with a large ischemic core: prospective cohort study”
Authors: Lingjia Xu, Haiyan Wang
Journal: International Journal of Surgery (2024)

Department of Neurology, Shaoxing Second Hospital, Shaoxing, Zhejiang, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Neurology, Shaoxing Second Hospital, Shaoxing, Zhejiang, China. E-mail address: [email protected] (H. Wang). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Letter to the editor for the article “Pharmacologic prevention and therapy of postoperative paralytic ileus after gastrointestinal cancer surgery – systematic review and meta-analysis”
Authors: Yajie Wang, Shumin Gao, Yisheng Pan
Journal: International Journal of Surgery (2024)

aDepartment of Gastrointestinal Surgery, Peking University First Hospital, Beijing, China bNational Institute on Drug Dependence, Peking University, Beijing, China Yajie Wang and Shumin Gao Contributed equally for the manuscript. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Gastrointestinal Surgery, Peking University First Hospital, Beijing, China, 100191. E-mail address: [email protected] (Y. Pan). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Artificial intelligence and augmented reality innovate skin tumor surgery: Continuous improvement and broadened applications
Authors: Hongda Li, Jianhua Li
Journal: International Journal of Surgery (2024)

aShandong University of Traditional Chinese Medicine bShandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences cDepartment of Dermatology, Dongying People's Hospital Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Dermatology, Dongying People's Hospital. Tel: +86 15689693072. E-mail address: [email protected] (J. Li). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Functional genotype-phenotype associations in recessive dystrophic epidermolysis bullosa
Authors: Jodi Y So, Jaron Nazaroff, Vamsi K Yenamandra, Emily S Gorell, Nicki Harris, Shivali Fulchand, Edward Eid, John A Dolorito, M Peter Marinkovich, Jean Y Tang
Journal: Journal of the American Academy of Dermatology (2024)
Enhancing pediatric postoperative pain management: strategies, challenges, and Innovations-A comprehensive review and observational study
Authors: Chengpin Tao, Yongsheng Cao, Junting Li
Journal: International Journal of Surgery (2024)

Department of Urology, Anhui Provincial Children's Hospital, Hefei,Anhui, 230041,China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding Author. Address: Anhui Provincial Children's Hospital, CHINA. E-mail address: [email protected] (C. Tao). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Letter to the editor “A real-time augmented reality robot integrated with artificial intelligence for skin tumor surgery - experimental study and case series”
Authors: Jie Wang, Ying Li, Jing Liu
Journal: International Journal of Surgery (2024)

First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: E-mail address: [email protected]) (Y. Li). *Corresponding author. Address: E-mail address: [email protected]) (J. Liu). This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0/
Factors contributing to weight loss success after bariatric procedures in patient over 65 years old - a multicenter retrospective cohort study
Authors: Izabela Karpińska, Natalia Dowgiałło-Gornowicz, Paula Franczak, Michał Orłowski, Paweł Lech, Grzegorz Kowalski, Piotr Major
Journal: International Journal of Surgery (2024)

Although bariatric surgery in patients over 65 years of age gives comparable results to treatment in the younger population, there are still controversies regarding the indications for surgery, risk assessment, and choice between different types of surgery. The study aimed to identify the factors contributing to weight loss success after bariatric surgery in patients over 65 years of age.
The professionalism of ChatGPT in the field of surgery: low or high level?
Authors: Haiyang Wu, Wanqing Li, Xiaofeng Chen, Cheng Li
Journal: International Journal of Surgery (2024)

aDepartment of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China bDepartment of Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China cDepartment of Operating Room, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China dDepartment of Orthopaedic Surgery, Yangxin People's Hospital, Yangxin, 435200, Hubei, China eDepartment of Orthopaedic Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China fCenter for Musculoskeletal Surgery (CMSC), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt University of Berlin, Berlin Institute of Health, Berlin, Germany Haiyang Wu, Zaijie Sun, and Xiaofeng Chen contributed equally to this study. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: The First Affiliated Hospital of Zhengzhou University Durham, NC UNITED STATES. E-mail address: [email protected] (H. Wu). *Corresponding author. Address: . E-mail address: [email protected] (C. Li). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A new MVA ancestor-derived oncolytic vaccinia virus induces immunogenic tumor cell death and robust antitumor immune responses
Authors: Juan J. Rojas, Lien Van Hoecke, Miquel Conesa, Carmen Bueno-Merino, Ana del Canizo, Stephanie Riederer, Maria Barcia, Katrin Brosinski, Michael H. Lehmann, Asisa Volz, Xavier Saelens, Gerd Sutter
Journal: Molecular Therapy (2024)

Vaccinia viruses (VACV) are versatile therapeutic agents and different features of various VACV strains allow for a broad range of therapeutic applications. Modified Vaccinia virus Ankara (MVA) is a particularly altered VACV strain that is highly immunogenic, incapable of replicating in mammalian hosts, and broadly used as a safe vector for vaccination. Alternatively, Western Reserve (WR) or Copenhagen (Cop) are VACV strains that efficiently replicate in cancer cells and therefore are used to develop oncolytic viruses. However, the immune evasion capacity of WR or Cop hinders their ability to elicit antitumor immune responses, which is crucial for efficacy in the clinic. Here, we describe a new VACV strain named Immune-Oncolytic Vaccinia virus Ankara (IOVA), which combines efficient replication in cancer cells with induction of immunogenic tumor cell death (ICD). IOVA was engineered from an MVA ancestor and shows superior cytotoxicity in tumor cells. In addition, the IOVA genome incorporates mutations that lead to massive fusogenesis of tumor cells, which contributes to improved antitumor effects. In syngeneic mouse tumor models, induction of ICD results in robust antitumor immunity directed against tumor neo-epitopes and eradication of large established tumors. These data present IOVA as an improved immunotherapeutic oncolytic vector.
A commentary on “efficacy of surgical intervention over conservative management in intertrochanteric fractures among nonagenarians and centenarians: a prospective cohort study”
Authors: Zhaokai Jin, Kuangying Xu, Yi Tang, Peijian Tong
Journal: International Journal of Surgery (2024)

aThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China bThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: The First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou, Zhejiang, 310006, China. E-mail address: [email protected] (P. Tong). This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0/
Assessment of surgery delay-associated risk in resectable stage I-IIIA non-small cell lung cancer
Authors: Zhenyi Niu, Yijun Wu, Runsen Jin, Hecheng Li
Journal: International Journal of Surgery (2024)

Niu, Zhenyi MD; Wu, Yijun MD; Jin, Runsen MD; Li, Hecheng MD, PhD, FACS Author Information
Sleep: a neglected public health issue
Authors: None The Lancet Diabetes & Endocrinology
Journal: The Lancet Diabetes & Endocrinology (2024)

Controlled by circadian rhythms and sleep–wake homeostasis, sleep is a state of reduced mental and physical activity—a time for body and mind to recharge in preparation for the next day. Although adults aged 18 years and older are recommended to get 7–9 h of sleep per day (and children up to 12 h), the 24/7 economy, modern lifestyles, job stresses, and living environments adversely affect the timing, duration, and quality of sleep for many people.
A commentary on “causal effects of gut microbiota on renal tumor: a mendelian randomization study”
Authors: Zhen Huang, Baisheng Ye, Wei Li, Xiaolin Shi
Journal: International Journal of Surgery (2024)

aThe Second School of Clinical Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310053, China bThe Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou,310000, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding Author. Address: Xinhua Hospital of zhejiang Province: The Second Affiliated Hospital of Zhejiang, Chinese Medical University, CHINA, Tel:+86 13516724553. E-mail address: email: [email protected] (X. Shi). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
A commentary on “clinical results of a 10-year follow-up of surgical treatment for elbow stiffness in rheumatoid arthritis: a case series”
Authors: Ying Zhu, Chujun Luo, Xinchang Wang
Journal: International Journal of Surgery (2024)

aThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China bThe Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: The Second Affiliated Hospital of Zhejiang Chinese Medical University, 318 Chaowang Road, Gongshu District, Hangzhou, Zhejiang, 310005, People's Republic of China. E-mail address: [email protected] (X. Wang). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Does an aptitude for surgery exist and can we predict it? an experimental study
Authors: Zino Ruchay, Julian Pape, Julia-Sophie Cordt, Carolina Kerres, Sebastian Siehl, Karina Jansone, Johannes Ackermann, Guenther Veronika, Mettler Liselotte, Leila Allahqoli, Nicolai Maass, Nees Frauke, Ibrahim Alkatout
Journal: International Journal of Surgery (2024)

The selection and allocation of surgeons with a greater potential for high surgical performance are essential aspects of improving the quality, safety, and effectiveness of surgical procedures. Objective of this trial was to determine the existence of basic skills and traits that would predict better performance in surgery, and those predictive factors that constitute a driving force in different stages of training.
Letter to the editor: Limitations of acetylcholinesterase inhibitor (AChEI) therapy for Alzheimer’s disease
Authors: Guang Yang, Jiawen Wu, Hang Lei, Yining Hui
Journal: International Journal of Surgery (2024)

aDepartment of Neurology, Kunshan Hospital of Traditional Chinese Medicine,Kunshan bInstitute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China cSouthwest Medical University, Luzhou 646000, China Guang Yang, Jiawen Wu, Hang Lei: These authors have contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Southwest Medical University, Luzhou 646000, China. E-mail address: [email protected] (Y. Hui). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Extended pleurectomy decortication and chemotherapy versus chemotherapy alone for pleural mesothelioma (MARS 2): a phase 3 randomised controlled trial
Authors: Eric Lim, David Waller, Kelvin Lau, Jeremy Steele, Anthony Pope, Clinton Ali, Rocco Bilancia, Manjusha Keni, Sanjay Popat, Mary O'Brien, Nadza Tokaca, Nick Maskell, Louise Stadon, Dean Fennell, Louise Nelson, John Edwards, Sara Tenconi, Laura Socci, Robert C Rintoul, Kelly Wood, Amanda Stone, Dakshinamoorthy Muthukumar, Charlotte Ingle, Paul Taylor, Laura Cove-Smith, Raffaele Califano, Yvonne Summers, Zacharias Tasigiannopoulos, Andrea Bille, Riyaz Shah, Elizabeth Fuller, Andrew Macnair, Jonathan Shamash, Talal Mansy, Richard Milton, Pek Koh, Andreea Alina Ionescu, Sarah Treece, Amy Roy, Gary Middleton, Alan Kirk, Rosie A Harris, Kate Ashton, Barbara Warnes, Emma Bridgeman, Katherine Joyce, Nicola Mills, Daisy Elliott, Nicola Farrar, Elizabeth Stokes, Vikki Hughes, Andrew G Nicholson, Chris A Rogers
Journal: The Lancet Respiratory Medicine (2024)

Extended pleurectomy decortication for complete macroscopic resection for pleural mesothelioma has never been evaluated in a randomised trial. The aim of this study was to compare outcomes after extended pleurectomy decortication plus chemotherapy versus chemotherapy alone.
From genetic associations to genes: methods, applications, and challenges
Authors: Ting Qi, Liyang Song, Yazhou Guo, Chang Chen, Jian Yang
Journal: Trends in Genetics (2024)

Genome-wide association studies (GWASs) have identified numerous genetic loci associated with human traits and diseases. However, pinpointing the causal genes remains a challenge, which impedes the translation of GWAS findings into biological insights and medical applications. In this review, we provide an in-depth overview of the methods and technologies used for prioritizing genes from GWAS loci, including gene-based association tests, integrative analysis of GWAS and molecular quantitative trait loci (xQTL) data, linking GWAS variants to target genes through enhancer-gene connection maps, and network-based prioritization. We also outline strategies for generating context-dependent xQTL data and their applications in gene prioritization. We further highlight the potential of gene prioritization in drug repurposing. Lastly, we discuss future challenges and opportunities in this field.
Challenges and considerations in interpreting the age-dependent benefit of neoadjuvant treatment for adenocarcinoma of the esophagus and gastroesophageal junction
Authors: Kexun Li, Hongchi Yan, Tengfei Ke
Journal: International Journal of Surgery (2024)

aDepartment of Thoracic Surgery I, Key Laboratory of Lung Cancer of Yunnan Province, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Cancer Center of Yunnan Province, Kunming, China bChangning County Traditional Chinese Medicine Hospital, Yibin, China cDepartment of Radiology, Yunnan Cancer Hospital,the Third Affiliated Hospital of Kunming Medical University, Kunming,China Dose Old Patients Benefit Less From Neoadjuvant Treatment Compared to Younger Patients in Overall Survival ? Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: 519 Kunzhou Road, Xishan District, Kunming City, Yunnan Province, China. Tel: +861821358857. E-mail address: [email protected] (T. Ke). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
MRI-based deep learning and radiomics for prediction of occult cervical lymph node metastasis and prognosis in early-stage oral and oropharyngeal squamous cell carcinoma: a diagnostic study
Authors: Tianjun Lan, Shijia Kuang, Peisheng Liang, Chenglin Ning, Qunxing Li, Liansheng Wang, Youyuan Wang, Zhaoyu Lin, Huijun Hu, Lingjie Yang, Jintao Li, Jingkang Liu, Yanyan Li, Fan Wu, Hua Chai, Xinpeng Song, Yiqian Huang, Xiaohui Duan, Dong Zeng, Jinsong Li, Haotian Cao
Journal: International Journal of Surgery (2024)

The incidence of occult cervical lymph node metastases (OCLNM) is reported to be 20-30% in early-stage oral cancer and oropharyngeal cancer. There is a lack of an accurate diagnostic method to predict occult lymph node metastasis and to help surgeons make precise treatment decisions.