tbuckley/cabot-search huggingface dataset:
POS1418 ESOPHAGEAL MUCOSAL EROSIONS CAN PREDICT THE DETERIORATION OF LUNG FUNCTION OVER A FOUR-YEAR FOLLOW-UP PERIOD AND LONG-TERM MORTALITY IN PATIENTS WITH INTERSTITIAL LUNG DISEASE ASSOCIATED WITH SCLERODERMA
Authors: E. De Lorenzis, G. Alonzi, G. Natalello, L. Berardini, L. Verardi, P. G. Cerasuolo, A. Papa, L. Richeldi, M. A. D’agostino, S. L. Bosello
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Interstitial lung disease (ILD) is a major cause of morbidity and disease-related death in systemic sclerosis (SSc). Esophageal disease is common in SSc, and micro-aspiration of gastroesophageal reflux may contribute to the pathogenesis of ILD. <h3>Objectives:</h3> The aim of this study is to explore the association of erosive esophagitis (EE) determined by esophagogastroduodenoscopy (EGD) with lung function deterioration and survival in patients with SSc. <h3>Methods:</h3> Consecutive patients presenting with symptoms of gastro-esophageal involvement who underwent EGD from 2005 to 2015 were characterized based on the occurrence of EE, following the Los Angeles criteria [1], and longitudinally evaluated. Patients with SSc-ILD were assessed over a 48-month period for pulmonary function test deterioration according to OMERACT criteria [2]. Both raw and SSc-associated mortality were documented over a ten-year period for the entire cohort. SSc patients, with or without EE, were compared though survival analysis. A competing risk survival analysis was specifically performed to investigate the association of EE with SSc-related mortality with death due to alternative causes as competing event. <h3>Results:</h3> Of the 214 SSc patients studied, 9.8% were male, the mean age was 58.8±13.5 years, the median disease duration was 5.0 years (IQR 1.0-9.0), and the diffuse variant was present in 36.9%. Out of these patients, 33.6% had EE and 59.8% had ILD and no association was found between these two disease characteristics. Forty-nine SSc-ILD patients experienced OMERACT deterioration. EE was associated with a reduced OMERACT progression-free survival (Log-Rank p=0.015) (Figure 1A) and an independently doubled risk of progression (HR 1.97, 95% CI 1.09-3.55 adjusted for age, gender, digital ulcers, disease duration, p=0.025). In the overall cohort, fifty-one deaths were reported, 37 of which were SSc-related. In the ILD group, there were a total of 27 deaths due to any cause, with 23 specifically due to SSc. EE was associated with the risk of SSc-related death in the ILD group (HR 2.08, 95% CI 1.05-5.28, Fine-Gray p=0.038) (Figure 1B), but not in SSc patients without ILD. <h3>Conclusion:</h3> In our cohort, EE represents a risk factor for functional deterioration and SSc-related long-term mortality specifically in SSc patients with ILD, supporting a detrimental role of gastro-esophageal micro-aspiration in exacerbating lung fibrosis. <h3>REFERENCES:</h3> [1] Lundell LR, Gut. 1999;45(2):172-80.[2] Khanna D, J Rheumatol. 2015;42(11):2168-71. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
AB0962 STATUS OF HOME EXERCISE AND PHYSICAL THERAPY IN SOUTHERN CHINESE PATIENTS WITH ANKYLOSING SPONDYLITIS
Authors: Y. LI, Z. Liao
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> In ASAS/EULAR recommendations for management of ankylosing spondylitis, home exercise and physical therapy are effective non-pharmacological methods. But the non-pharmacological therapy is ignored by the rheumatologists in China for a long time. <h3>Objectives:</h3> This study aimed to investigate the status and home exercise and physical therapy in patients with ankylosing spondylitis from southern China. <h3>Methods:</h3> A network survey questionnaire was distributed by social software WeChat to an AS patients group. The questionnaire included questions about disease status, non-pharmacological methods received, contents and effects of exercise and physical therapy. A descriptive statistics was performed for the individual question. <h3>Results:</h3> (1)Totally one hundred and twenty-eight patients which contained 92 male and 36 female filled the questionnaire. More than 62,5% of patients (80/128) had more than 10 years of disease duration, and 71% (91/128) had moderate to severe symptoms. 85.9% of patients had received NSAIDs and 56.3% received biological agents. (2) About home exercise, 66.4% (85/128) of patients hadn't had home exercises. The reasons included no enough time (42.4%), couldn't persist (48.2%), too pain to exercise (25,9%), and etc. In patients who carried out regular exercises (43/128), most of them had pulling motions (60.5%) and aerobic exercises (46.5%). But most of them learned the exercise methods from internet by themselves (62.8%). Few of them got direct from their doctors (32,6% from rheumatologists and 25.6% from rehabilitation doctors. About half of patients thought exercise could help pain releasing (48.8%) and improving sport ability (46.5%). (3) About physical therapy, 42,2% of patients received Chinese traditional acupuncture and massage, and 23.4% received other physical factors therapy such as heat, ultrasound, etc. 64.8% of patients thought physical therapy could help pain releasing, and 40.6% thought it could help blood circulation. Interestingly, about 71.9% of patients didn't continue the physical therapy because of lack of effect and boring to use. <h3>Conclusion:</h3> This network survey described the home exercise and physical therapy status in a Chinese AS patient group with long disease duration. Few Chinese AS patients preformed regular home exercise and less of them got professional directs. Chinese traditional physical therapies were commonly used in AS patients, but hard to persist. Rehabilitation treatment should be paid more attention in AS patients in China. <h3>REFERENCES:</h3> <b>NIL.</b> <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
AB0908 PREVALENCE OF DIABETES IN AXIAL SPONDYLOARTHRITIS: SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: L. Gumber, H. Samarasinghe, P. Gladston, A. Moorthy
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Axial spondyloarthritis (axSpA) is a chronic inflammatory condition with an increased risk of cardiovascular events. Diabetes is a well-established risk factor for cardiovascular disease and stroke. Multiple lines of evidence have suggested a connection between axSpA and diabetes due to inflammatory processes and shared risk factors<sup>1</sup>. <h3>Objectives:</h3> This study aimed to conduct a systematic review and meta-analyses to: (i) identify the prevalence of diabetes in axSpA and (ii) compare the risk of diabetes between axSpA and control populations. <h3>Methods:</h3> A comprehensive literature search was conducted for articles published between 1 January 2000 and 15 November 2023 using Medline, Embase and Scopus. All observational studies reporting prevalence, incidence, or risk of diabetes in axSpA were included. Studies not published in English were excluded. Search results were independently screened by at least two reviewers, and data extracted into a proforma. A meta-analysis was performed using a random-effects model. The methodological quality of each included study was assessed using the JBI critical appraisal tool. The study protocol was registered in PROSPERO (CRD42023482573). <h3>Results:</h3> In total, 2257 articles were identified, from which 23 studies were included for analysis amounting to a combined sample size of 65 025 patients. The pooled prevalence of diabetes in patients with axSpA was 7.0% (95% CI 5.0-8.0%) which was statistically significant (p=0.00). There was also a significantly higher odds of diabetes in patients with axSpA compared to controls (pooled OR 1.29, 95% CI 1.08-1.55). The funnel plot was symmetric, thereby indicating a low risk of publication bias. <h3>Conclusion:</h3> Our findings indicate that the prevalence of diabetes in patients with axSpA is high. Routine screening for diabetes and lifestyle modifications should be encouraged in this population. <h3>REFERENCES:</h3> [1] Hintenberger R, Affenzeller B, Vladychuk V, et al. Cardiovascular risk in axial spondyloarthritis-a systematic review. <i>Clin Rheumatol</i> 2023; 42: 2621–2633. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> Leher Gumber: None declared, Harini Samarasinghe: None declared, Praveen Gladston: None declared, Arumugam Moorthy Previously received speaker fee from Ellily, Galapagos and Novartis but not related to this project.
AB0848 COMPARISON OF FATIGUE AND ASSOCIATED FACTORS AMONG PATIENTS WITH PRIMARY AND SECONDARY SJOGREN’S SYNDROME AND PATIENTS WITH CONNECTIVE TISSUE DISEASE WITHOUT SJOGREN’S SYNDROME
Authors: K. A. Lee, H. Jeon
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Fatigue is a prevalent symptom in Sjogren's syndrome (SS) patients with dryness and pain serving as robust predictors. <h3>Objectives:</h3> This study compares fatigue levels among patients with primary SS (pSS), secondary SS (SS), and those with connective tissue disorder (CTD) without SS, while exploring associated factors. <h3>Methods:</h3> In this single-center, cross-sectional study, adult patients with pSS, sSS, and CTD without SS were assessed using the EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI), patient global assessment (PGA), and Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) (higher FACIT-F scores indicates less fatigue). <h3>Results:</h3> Results from 115 pSS, 125 sSS, and 52 CTD without SS patients showed significant differences in median FACIT-F (30 vs. 36 vs. 42) and ESSPRI (5.5 vs. 4.3 vs. 4.1) (all P-values &lt; 0.05). Compared to sSS, pSS patients reported more severe symptoms in FACIT-F's experience domain and ESPPRI's fatigue and dryness domain. Fatigue severity correlated with pain, dryness, and PGA in all three groups. Multivariate regression analysis identified subjective pain and dryness as independent predictors of fatigue in both pSS and sSS groups. In pSS patients, female gender, fibromyalgia and arthritis were associated with fatigue, while in sSS patients, CRP levels was linked to fatigue. <h3>Conclusion:</h3> Patients with pSS reported more severe fatigue than those with sSS or CTD patients without SS. Independent risk factors for fatigue in pSS patients included female gender, fibromyalgia, arthritis, subjective pain, and dryness, differing somewhat from sSS patients. Proper management of arthritis and fibromyalgia could ameliorate fatigue in pSS patients. <h3>REFERENCES:</h3> [1] Zhao R, Dong C, Gu Z, Ding X, Li J. Development and validation of a nomogram for predicting fatigue in patients with primary Sjögren's syndrome. <i>Clin Rheumatol</i>. Published online December 28, 2023. doi:10.1007/s10067-023-06853-9 <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
AB1092 MONTREAL COGNITIVE ASSESSMENT (MOCA) AND SYMBOL DIGIT MODALITIES TEST（SDMT）AS A SCREENING TOOL FOR EVALUATION OF COGNITIVE IMPAIRMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Q. Huang, X. Huang, P. Wang, B. Zhou, Q. Cui, M. Yang
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Cognitive impairment is a common occurrence in individuals with systemic lupus erythematosus (SLE),a chronic autoimmune disease. This impairment falls under the category of centra-l nervous system disorders, known as neuropsychiatric SLE(NPSLE). The American College of Rheumatology recom-mends the use of the 1-hour neuropsychological test (ACR-NB) as the gold standard for diagnosing cognitive impairment in SLE patients. However, due to its time-consuming nature and requirement for specialized personnel, its practicality in clinical settings is limited. Therefore, the development of accurate and practical screening tools is warranted. <h3>Objectives:</h3> This study aims to evaluate the concurrent reliability and validity of Montreal Cognitive Assessment (MoCA) and Symbol Digit Modalities Test (SDMT) in identifying cognitive impairment among patients with systemic lupus erythematosus comparing with ACR-NB. <h3>Methods:</h3> Cognitive function was evaluated in 50 SLE patients and 50 healthy controls who were matched for sex, age, and years of education using ACR-NB, MoCA, and SDMT. Utilizing ACR-NB as the referencestandard, we examined three definitions of cognitive impairment, employed binary logistic regressio-n to generate predictive probabilities of combined screening tools (MoCA and SDMT), and compared the area under the curve (AUC), sensitivity, and specificity of MoCA, SDMT, and the combined screeni-ng tools. <h3>Results:</h3> As assessed by ACR-NB, the combination of MoCA and SDMT demonstrates good reliability and valid-ty, significantly reducing the required testing time.When patients were classified as severe cognitive impairment if there were two cognitive domains with SD &gt;2 below the HC group mean,a MoCA score < 26 and a SDMT score < 42 were determined as optimal cutoff points, based on having the highest Younden's index (0.68 and 0.74respectively). The composite screening tool, consisting of both MoCA and SDMT, had an area under the ROC curve (AUC) value of 0.94 (P &lt; 0.01), which was significantly hi-gher by 0.10 compared to using only MoCA alone. For patients with moderate cognitive impairment identified as two cognitive domains with SD &gt;1.5 below the HC group mean,the AUC value for the co-mposite screening tool was found to be 0.90 (P &lt; 0.01). For patients with mild cognitive impairment identified as one cognitive domain with SD &gt;2 below the HC group mean, the AUC value for the com-posite screening tool was found to be 0.85 (P &lt; 0.01)(Table 1 and Figure 1). <h3>Conclusion:</h3> The combined detection of MoCA and SDMT represents a quick and accurate screening tool for asses-sing cognitive impairment in patients with systemic lupus erythematosus. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
AB0853 THE LONG-TERM OUTCOME OF RENAL INVOLVEMENT IN PRIMARY SJOGREN’S SYNDROME
Authors: W. U. Kim, J. H. Koh, Y. Park, H. Jeon, Y. S. Suh, Y. S. Suh
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Renal involvement is a rare manifestation of primary Sjögren's syndrome (pSS). The long-term outcome of renal disease in pSS remains poorly understood. <h3>Objectives:</h3> This observational study aimed to investigate the prevalence, clinical features, and long-term prognosis of renal involvement in pSS. <h3>Methods:</h3> A multicenter, retrospective longitudinal study was performed using laboratory data and medical chart review. Renal outcome was compared between patients with and without renal involvement, matched for age and sex. <h3>Results:</h3> Among 1306 pSS patients (mean age, 51 years; 98% female), 28 (2.1%) exhibited renal disease; 15 with tubular interstitial nephritis (TIN), 11 with glomerulonephritis (GN), and one with both. Those with renal involvement showed a higher prevalence of hypergammaglobulinemia, positive Ro, La antibodies, and rheumatoid factor. The prevalence of hematological malignancies was significantly higher in patients with renal involvement (10% vs. 1%, P = 0.020). Sixty-three percent of TIN patients were treated with potassium citrate, while high-dose glucocorticoids were administered to some TIN and GN patients. Over the mean 8.5-year follow-up, 25% of TIN and GN patients experienced significant renal function decline. Renal involvement was identified as a significant risk factor for hematological malignancy. <h3>Conclusion:</h3> A quarter of pSS patients with renal involvement experienced renal function deterioration. Early detection and proper management through appropriate screening are crucial. Additionally, monitoring for hematological malignancies is recommended in pSS patients with renal involvement. <h3>REFERENCES:</h3> [1] François H, and Mariette X. Renal involvement in primary Sjögren syndrome. <i>Nat Rev</i> Nephrol. 2016;12(2):82-93. [2] Maripuri S, Grande JP, Osborn TG, Fervenza FC, Matteson EL, Donadio JV, and Hogan MC. Renal involvement in primary Sjögren's syndrome: a clinicopathologic study. Clin <i>J Am Soc Nephrol.</i> 2009;4(9):1423-31. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
AB0923 LATENT TUBERCULOSIS RESCREENING IN SPONDYLOARTHRITIS: HOW SHOULD LATENT TUBERCULOSIS NEGATIVE PATIENTS BE FOLLOWED UP?
Authors: Z. Özsoy, A. Ozdemir, M. Ekici, E. Bilgin, A. Eken, F. Çakmak, Z. Saribaş, B. Şener, A. I. Ertenli, O. Karadag, L. Kiliç
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> The frequency of rescreening and monitoring for latent tuberculosis (TB) infection (LTBI) in patients with inflammatory arthritis on biological therapy is uncertain. Some health authorities recommend annual LTBI screening for patients who initially test negative. <h3>Objectives:</h3> The aim of this study was to evaluate the effectiveness of LTBI rescreening using the IGRA method and to assess the frequency of rescreening in real-life spondyloarthritis (SpA) patients on biological therapy. <h3>Methods:</h3> This study focused on patients with SpA who were scheduled for b-DMARD treatment and underwent QFT-Plus testing to screen for latent tuberculosis infection (LTBI). The study recorded demographic information, blood chemistry test results, comorbidities, and smoking status of the patients along with the QFT-Plus test. The results of the QFT-Plus test were analysed as positive, negative, or indeterminate. The study also analysed whether IGRA-negative patients underwent repeat IGRA tests during follow-up and the timing of these tests. Cases of tuberculosis reactivation during follow-up were documented, and the clinical status of affected patients was recorded. The study also investigated the management of patients who initially tested negative for IGRA but tested positive on subsequent follow-up tests, even if they did not show symptoms of active tuberculosis. <h3>Results:</h3> Of the 946 patients included in the study, 534 (56.4%) were female and the median age was 41 years (min:18-max:80). The QFT-Plus test was positive in 107 (11.3%) patients and negative in 827 (87.4%) (Figure 1). The median duration of disease follow-up for initial IGRA negative patients was 27 months (min-max: 0-52). Follow-up tests were carried out only 67 (%8.1) of the 827 initial IGRA negative patients. Among them, 65 patients had negative results, while two asymptomatic patient was positive for rescreening test and they continued their biological treatment while receiving INH prophylaxis. Remarkably, only one patient (0.13%), who was IGRA negative at the initation of biological treatment and did not undergo a follow-up test, exhibited positivity for TB in a sputum culture at the 27th month of follow-up (Figure 2). <h3>Conclusion:</h3> This study found that compliance with annual testing was particularly low in patients without LTBI. On the other hand, the occurrence of TB infection or activation in IGRA-negative patients was extremely rare over a median follow-up of 27 months. These results suggest that national and international guidelines may need to be updated to reflect real-world data and clinical practice. <h3>REFERENCES:</h3> <b>NIL.</b> <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>
AB0938 PERFORMANCE OF INFLAMMATORY BACK PAIN CRITERIA FOR SPONDYLARTHRITIS: ASAS CRITERIA MIGHT HAVE OVERALL BETTER PERFORMANCE
Authors: H. Kocaayan, A. Özkan, O. Yogurtcu, H. İ. Y. Atli, E. Erpek, E. Durak Ediboglu, İ. Kurut Aysin, E. Otman, H. Cinakli, G. Alp, S. Gucenmez, M. Ozmen, D. Solmaz, S. Akar
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Objectives:</h3> To evaluate the performance characteristics of inflammatory low back pain (IBP) criteria sets and to demonstrate the discriminative values of individual items of IBP criteria in patients with axSpA. <h3>Methods:</h3> A total 706 patients referred to a single center with back pain and a suspicion of spondyloarthritis (SpA) were included in this analysis. According to ASAS criteria, 568 patients were classified as axial SpA (axSpA) (37.9% female; mean age: 39.9 ±11.6 years) and 138 were classified as non-SpA (72.5% female; mean age: 36.6 ±10.2 years) by the physician. Demographic and clinical characteristics were collected by using a standardized form. Calin, Berlin and ASAS criteria were used for IBA classification. A BASDAI score of ≥4 or an ASDAS score of ≥2.1 used as cut of for the definition of active disease. <h3>Results:</h3> HLA B27 positivity, male sex were higher and duration of back pain was found to be longer in patients classified as axSpA. Interestingly more patients were classified as active according to BASDAI score in non-SpA group, however as expected mean serum CRP level was higher among patients with axSpA. The demographic and disease related characteristics were summarized in Table 1. It was observed that a significant proportion of patients in non-SpA could be classified as IBA (79.7%-62.3%) according to different criteria sets. The sensitivities of Calin, Berlin, ASAS criteria sets in AxSpA were 90.3%, 77.0%, and 82.6%, respectively. Berlin and ASAS criteria sets had better specificity in comparison with Calin criteria. In addition diagnostic Odds of ASAS set was found to be a bit higher. Morning stiffness, improvement with exercise, and insidious onset items were significantly higher in the axSpA group. In addition, all components of the Berlin criteria for IBA were significantly different between the axSpA and non-SpA groups (Table 1). <h3>Conclusion:</h3> In this group of patients referred with back pain and a suspicion of axSpA demonstrated that considerable proportion of patients who could not be classified as axSpA might have IBA according to the different IBA criteria sets. However ASAS and Berlin crfiteri may be more specific for axSpA. In our study group overall diagnostic performance of ASAS criteria might be better. <h3>REFERENCES:</h3> <b>NIL.</b> <h3>Acknowledgements:</h3> Thank you for your scientific support. <h3>Disclosure of Interests:</h3> <b>None declared.</b>