Acupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in Pregnancy
Authors: Jing-Shu Gao, Hong-Li Ma, Chi Chiu Wang, Tian Xie, Xiao-Ke Wu
Journal: Annals of Internal Medicine (2024)

LettersFebruary 2024Acupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in PregnancyJing-Shu Gao, MSc, Hong-Li Ma, MD, Chi Chiu Wang, MD, PhD, Tian Xie, PhD, Xiao-Ke Wu, MD, PhDJing-Shu Gao, MScFirst Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, and College of Pharmacy, The Department of Medicine, Hangzhou Normal University, Hangzhou, China, Hong-Li Ma, MDFirst Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China, Chi Chiu Wang, MD, PhDDepartment of Obstetrics & Gynaecology, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, and The Chinese University of Hong Kong–Sichuan University Joint Laboratory in Reproductive Medicine, The Chinese University of Hong Kong, Hong Kong, China, Tian Xie, PhDHolistic Integrative Pharmacy Institutes of Medicine School, Hangzhou Normal University, Hangzhou, Zhejiang, China, Xiao-Ke Wu, MD, PhDFirst Affiliated Hospital, Heilongjiang University of Chinese Medicine, and Heilongjiang Provincial Hospital, Harbin, ChinaAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L23-0427 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE: We appreciate and agree with Drs. Fan and Gu's comment that our sham acupuncture control intervention is a form of acupressure or a mild form of active acupuncture and that the true effect of active acupuncture therefore may be underestimated. Evidence suggests that physiologic effects may be generated by this kind of control acupuncture (1). Two common sham acupuncture protocols are adopted in many acupuncture trials, namely, superficial and nonpenetrating acupuncture. In our trial, nonpenetrating acupuncture was used. Application of a blunt needle without skin penetration at the acupoint allowed for superior blinding and fewer effects than superficial ...References1. Vickers AJ, Vertosick EA, Lewith G, et al; Acupuncture Trialists' Collaboration. Do the effects of acupuncture vary between acupuncturists? Analysis of the Acupuncture Trialists' Collaboration individual patient data meta-analysis. Acupunct Med. 2021;39:309-317. [PMID: 33300369] doi:10.1177/0964528420959089 CrossrefMedlineGoogle Scholar2. Fei YT, Cao HJ, Xia RY, et al. Methodological challenges in design and conduct of randomised controlled trials in acupuncture. BMJ. 2022;376:e064345. [PMID: 35217507] doi:10.1136/bmj-2021-064345 CrossrefMedlineGoogle Scholar3. Jung WM, Park IS, Lee YS, et al. Characterization of hidden rules linking symptoms and selection of acupoint using an artificial neural network model. Front Med. 2019;13:112-120. [PMID: 29651775] doi:10.1007/s11684-017-0582-z CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Jing-Shu Gao, MSc; Hong-Li Ma, MD; Chi Chiu Wang, MD, PhD; Tian Xie, PhD; Xiao-Ke Wu, MD, PhDAffiliations: First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, and College of Pharmacy, The Department of Medicine, Hangzhou Normal University, Hangzhou, ChinaFirst Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Obstetrics & Gynaecology, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, and The Chinese University of Hong Kong–Sichuan University Joint Laboratory in Reproductive Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHolistic Integrative Pharmacy Institutes of Medicine School, Hangzhou Normal University, Hangzhou, Zhejiang, ChinaFirst Affiliated Hospital, Heilongjiang University of Chinese Medicine, and Heilongjiang Provincial Hospital, Harbin, ChinaDisclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L23-0427. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAcupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in Pregnancy Xiao-Ke Wu , Jing-Shu Gao , Hong-Li Ma , Yu Wang , Bei Zhang , Zhao-Lan Liu , Jian Li , Jing Cong , Hui-Chao Qin , Xin-Ming Yang , Qi Wu , Xiao-Yong Chen , Zong-Lin Lu , Ya-Hong Feng , Xue Qi , Yan-Xiang Wang , Lan Yu , Ying-Mei Cui , Chun-Mei An , Li-Li Zhou , Yu-Hong Hu , Lu Li , Yi-Juan Cao , Ying Yan , Li Liu , Yu-Xiu Liu , Zhi-Shun Liu , Rebecca C. Painter , Ernest H.Y. Ng , Jian-Ping Liu , Ben Willem J. Mol , and Chi Chiu Wang Acupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in Pregnancy Arthur Yin Fan , and Sherman Gu Acupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in Pregnancy Qi Wang Metrics Current IssueFebruary 2024Volume 177, Issue 2KeywordsAcupunctureNauseaPregnancyRandomized trialsVomiting ePublished: 20 February 2024 Issue Published: February 2024 Copyright & PermissionsCopyright © 2024 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...