tbuckley/cabot-search huggingface dataset:
Coupled systolic-ventricular and vascular stiffening with age
Authors: Chen-Huan Chen, Masaru Nakayama, Erez Nevo, Barry J Fetics, W.Lowell Maughan, David A Kass
Journal: Journal of the American College of Cardiology (1998)

Objectives. We tested the hypothesis that age-related arterial stiffening is matched by ventricular systolic stiffening, and that both enhance systolic pressure sensitivity to altered cardiac preload. Background. Arterial rigidity with age likely enhances blood pressure sensitivity to ventricular filling volume shifts. Tandem increases in ventricular systolic stiffness may also occur and could potentially enhance this sensitivity. Methods. Invasive left ventricular pressure-volume relations were measured by conductance catheter in 57 adults aged 19 to 93 years. Patients had normal heart function and no cardiac hypertrophy and were referred for catheterization to evaluate chest pain. Twenty-eight subjects had normal coronary angiography and hemodynamics, and the remaining had either systolic hypertension or coronary artery disease without infarction. Data recorded at rest and during transient preload reduction by inferior vena caval obstruction yielded systolic and diastolic left ventricular chamber and effective arterial stiffness and pulse pressure. Results. Left ventricular volumes, ejection fraction and heart rate were unaltered by age, whereas vascular load and stiffening increased (p < 0.008). Arterial stiffening (Ea) was matched by increased ventricular systolic stiffness (Ees): Ees=0.91·Ea+0.53, (r = 0.50, p < 0.0001), maintaining arterial-heart interaction (Ea/Eesratio) age-independent. Ventricular systolic and diastolic stiffnesses correlated (r = 0.51, p < 0.0001) and increased with age (p < 0.03). Both ventricular and vascular stiffening significantly increased systolic pressure sensitivity to cardiac preload (p < 0.006). Conclusions. Arterial stiffening with age is matched by ventricular systolic stiffening even without hypertrophy. The two effects contribute to elevating systolic pressure sensitivity to altered chamber filling. In addition to recognized baroreflex and autonomic dysfunction with age, combined stiffening could further enhance pressure lability with diuretics and postural shifts in the elderly.
Identification Of a Novel Mode Of Kinase Inhibitor Resistance In JAK2: JAK2 Inhibitor Resistance Is Mediated By The Generation Of 45-Kda JAK2 Variant Which Alters The Kinase Domain Structure
Authors: Sivahari Prasad Gorantla, Nikolas von Bubnoff, Martina Rudelius, Corinna Albers, Anna Lena Illert, Heiko Becker, Christian Peschel, Justus Duyster
Journal: Blood (2013)
A phase I study of tumor treating fields (TTFields) in combination with pemetrexed for pretreated advanced non-small cell lung cancer
Authors: E. D. Kirson, U. Weinberg, D. Betticher, R. Von Moos, N. Fischer, J. Studt, M. Buess, N. Burger, Y. Palti, M. Pless
Journal: Journal of Clinical Oncology (2009)

e18500 Background: TTFields (tumor treating fields) are low intensity, intermediate frequency, alternating electric fields which slow the growth of solid tumors in-vivo, and have shown promise in pilot clinical trials in patients with advanced solid tumors. TTFields are a regional treatment which acts both by interfering with microtubules polymerization and by physical disruption of the cell structure during cytokinesis. It has been shown previously that TTFields sensitize non-small cell lung cultures to Pemetrexed. In-Vivo, TTFields did not increase pemetrexed related toxicity. Methods: A prospective trial was performed in 14, pretreated, stage IIIb-IV, NSCLC patients. Patients with brain metastases were excluded, as were patients with abnormal marrow, kidney, liver or cardiac functions. Patients with history of clinically significant arrhythmias or those having pacemakers were excluded as well. Patients received Pemetrexed 500mg/m 2 IV q3w together with daily TTFields (12 h/day) using a portable medical device (NovoTTF-100L). The device generated 2 direction (AP and Lat), 150 kHz TTFields. Patients were followed every three weeks and had a lung CT every 9 weeks. The primary endpoint was the safety and tolerability of the NovoTTF-100L device in combination with pemetrexed. Results: The 14 patients received an average of 4 courses of pemetrexed (Range 1–9) and a cumulative TTFields treatment time of 182 weeks. The device was well tolerated as indicated in the device log files which showed an average daily use of 11±1 hours. There were no device-related, nor pemetrexed-related SAEs. In addition, no unexpected abnormalities were evident in the lab tests or EKGs, done every 3 weeks for all patients. There were no reports of arrhythmias. The only device related AE seen in all patients was dermatitis under the electrodes. This improved with meticulous skin care, topical steroid use and in extreme cases oral steroids. One patient (7.6%) had a CR, 1 a PR (7.6%), 9 SD (69.2%) and 3 PD (23%). 77% of patients were progression free at 12 weeks and the 6 month survival was 89%. Conclusions: TTFields are well tolerated when given together with pemetrexed. The excellent safety profile and initial efficacy results reported here justify further clinical testing. [Table: see text]
Abstract 1815: Outcomes of the Norwood Operation in Infants Randomized to a Modified Blalock-Taussig versus Right Ventricle-to-Pulmonary Artery Shunt: The Pediatric Heart Network Single Ventricle Reconstruction Trial
Authors: Richard G Ohye, Sarah Tabbutt, Lynn A Sleeper, Gail D Pearson, Lynn Mahony, Jane W Newburger, Minmin Lu, Peter C Laussen, Caren S Goldberg, Nancy S Ghanayem, Peter C Frommelt, Andrew M Atz, Steven Colan, Jeffrey P Jacobs, James Jaggers, Kirk R Kanter, Catherine D Krawczeski, Alan B Lewis, Brian W McCrindle, L L Minick, Seema Mital, Christian Pizarro, Chitra Ravishankar, Ismee A Williams, J W Gaynor
Journal: Circulation (2009)
The Relationship of Left Ventricular Trabeculation to Ventricular Function and Structure Over a 9.5-Year Follow-Up
Authors: Filip Zemrak, Mark A. Ahlman, Gabriella Captur, Saidi A. Mohiddin, Nadine Kawel-Boehm, Martin R. Prince, James C. Moon, William G. Hundley, João A.C. Lima, David A. Bluemke, Steffen E. Petersen
Journal: Journal of the American College of Cardiology (2014)
Drug treatment of hypertension
Authors: D. G Hackam
Journal: BMJ (2003)

Medical staff need to be aware of major incident planningEditor-Last month the BMA warned that too few people in the United Kingdom know how to respond to a terrorist attack. 1 Its concerns about too few senior officials being aware of plans and recommendations to improve preparedness are sensible, but we believe that not enough medical staff are aware of their role in the event of a terrorist attack.We recently carried out a survey in the largest acute NHS trust of the south west of England to assess medical staff's knowledge about the local major incident plan.We sent questionnaires to the 107 doctors in North Bristol NHS Trust with a potential role in the mobile medical team if they were on duty during a major incident.Seventy seven doctors replied (72%).Sixty nine were aware of the existence of the local major incident plan, but only 26 had read part or all of it.Only 11 of the responding doctors were aware of their potential role in the mobile medical team.Of these 11 doctors, only three thought themselves adequately trained for this position, and all three had been trained as medical incident officers.Last year's National Audit Office report highlighted deficiencies in NHS plans to deal with major incidents in England. 2 It recommended upgrading training arrangements.Five months later some doctors are still unaware of their roles in the event of a terrorist attack.As a trust we are currently considering several measures to improve on our results.We suspect, however, that our findings are not unique and encourage other acute trusts to look closely at their staff's knowledge and training and act accordingly.
Abstract 10669: Activation of Retinoid Receptor-Mediated Signaling Ameliorates Diabetes-Induced Cardiac Dysfunction in Zucker Diabetic Fatty Rats
Authors: Rakeshwar S Guleria, Amar B Singh, Irina T Nizamutdinova, Tatiana Souslova, Amin A Mohammad, Kenneth M Baker, Jing Pan
Journal: Circulation (2012)
Titian's Schoolmaster
Authors: M. Therese Southgate
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatocellular Carcinoma: Contrast-Enhanced Sonography
Authors: Byung Ihn Choi, Se Hyung Kim
Journal: Liver Cancer (2009)

In patients with chronic liver disease, sono-graphy and measurements of serum alpha-fetoprotein (αFP) levels are frequently used to screen for hepatocellular carcinoma (HCC). The sensitivity of sonography for HCC detection, however, in the end-stage cirrhotic liver is only 50% (Dodd et al., 1992). Furthermore, sonographic findings of HCC are variable and frequently nonspecific. Hepatocellular carcinoma is highly vascularized and often shows irregular neovascularization within the tumor. Therefore, detection and characterization of tumor vascularity are important in the differential diagnosis, the choice of treatment method, and assessment of the therapeutic response for HCC. Although color and power Doppler sonography are helpful in detecting vascularity of hepatic tumors, it has not proved satisfactory. Since intravenous microbubble contrast agents including SH U 508A (Levovist; Schering AG, Berlin, Germany) for sonography have become available, many researchers have reported that contrast-enhanced sonography could be a promising technique for assessing post-treatment response of HCC (Bartolozzi et al., 1998; Choi, D. et al., 2000; Ding et al., 2001; Meloni et al., 2001; Solbiati et al., 1999; Youk et al., 2003b) as well as for making a correct diagnosis of HCC by observing tumoral vascularity (Choi et al., 2000a; Dill-Macky et al., 2002; Kim et al., 1998; Wen et al., 2004). Indeed, there is an increasing consensus that the use of contrast agents improves the ability of sonography to detect and characterize focal hepatic lesions. Levovist, one of the most popular sonographic contrast agents, is a suspension of galactose microparticles in sterile water. The microbubbles (2–8 μm in diameter, with a mean of 3 μm), which are stabilized in the microparticle suspension, can traverse the pulmonary capillary bed and diverse into whole blood circulation (Kim et al., 1998).
Safety results of a phase III randomized trial of adjuvant treatment with 5- fluorouracil and folinic acid with or without irinotecan, in Dukes B2 and C colon cancer
Authors: P. Papakostas, H. P. Kalofonos, G. Pentheroudakis, E. Timotheadou, C. Papadimitriou, D. Tsavdaridis, T. Economopoulos, E. Galani, D. Bafaloukos, G. Aravantinos
Journal: Journal of Clinical Oncology (2007)

4053 Background: The aim of our phase III study was to compare the effectiveness and the toxicity profile of 5-Fluorouracil (5- FU) + folinic acid (FA) + irinotecan (CPT-11) as adjuvant chemotherapy for resectable colon cancer (Dukes B2 and C) to that of 5-FU + FA which was considered the standard treatment. Since patients are still on follow-up regarding the primary endpoint, only safety results will be presented. Methods: Eligible patients received either 5-FU (450 mg/m 2 bolus) + FA (200 mg/m 2 , 120 min infusion) + CPT- 11 (80 mg/m 2 , 90 min infusion) given 4 weeks on, two weeks off for a total of 6 treatment cycles (Arm A) or 5-FU (500 mg/m 2 bolus) + FA (200 mg/m 2 , 120 min infusion) given 6 weeks on, two weeks off for a total of 4 treatment cycles (Arm B). Results: From January 1999 to September 2004, 910 patients (pts) were enrolled in this multi-center phase III trial. Safety data are available for 826 of the 910 pts, (415 in arm A and 411 in arm B). The total number of chemotherapy courses delivered was 8,906 (92%) in arm A and 8,775 (91%) in arm B, with median courses per patient 24 in both groups. Among patients who received treatment as randomized (403 in arm A and 398 in arm B), treatment was completed in 342 pts (82%) in arm A and in 341 pts (83%) in arm B. The number of patients who discontinued the treatment was 61 (15%) in arm A and 57 (14%) in arm B. Hospitalizations because of toxic effects happened in 37 pts (9%) in arm A and in 45 pts (11%) in arm B. Three deaths occurred in both arms. Use of G-CSF was more common in arm A (94 pts, 23%) than in arm B (38 pts, 9.5%) (p&lt; 0.001). Significantly higher grade 3/4 neutropenia was observed in group A (11% in arm A and 3% in arm B, p&lt; 0.001). Severe diarrhea was also frequently reported in both groups. Conclusions: These data show that both regimens have comparable and manageable toxicity profiles as adjuvant treatment in colon cancer. Severe neutropenia was more often seen in arm A. No significant financial relationships to disclose.
Abstract 2917: BNP Predicts Event-Free Survival in African American Patients with Moderate to Severe Heart Failure but does not Identify Responders to Fixed-dose Combination of Isosorbide Dinitrate / Hydralazine
Authors: J. Eduardo Rame, Teresa De Marco, Dana McGlothlin, Xinge Hu, Daniel L Dries, Manuel Worcel, S. William Tam, Jay N Cohn
Journal: Circulation (2007)

Background: Brain Natriuretic Peptide (BNP), a central component of the counter-regulatory cardiac hormonal system, is a well-validated prognostic indicator of clinical worsening and survival in co...
Abstract 15558: Increases in Dietary Fat Intake among the Framingham Heart Study Participants: Trends from 1991-2008
Authors: Maya Vadiveloo, Marc Scott, Paula Quatromoni, Paul Jacques, Niyati Parekh
Journal: Circulation (2012)

Introduction: Few longitudinal studies among US adults have evaluated long-term dietary intakes and whether national recommendations for macronutrient intake are met. The objective of this study wa...
Abstract 5022: Socioeconomic Disparities in Sudden Cardiac Arrest: Analysis of US Metropolitan Areas Within the Resuscitation Outcomes Consortium
Authors: Kyndaron Reinier, Sumeet S Chugh, Elizabeth Thomas, Thomas D Rea, Scott S Emerson, Tom P Aufderheide, Clifton W Callaway, Ahamed Idris, Ian Stiell
Journal: Circulation (2008)
Abstract 16473: Decreased Right Ventricular Strain Before Left Ventricular Assist Device Implantation is Associated With Adverse Early Outcome
Authors: Mingya Liu, Grace Lin, Yan Topilsky, Tal Hasin, Monica A Boege, Sudhir S Kushwaha, Jae K Oh, Soon J Park, Fletcher A Miller, Robert P Frantz, Peter A Brady
Journal: Circulation (2011)

Background: Right ventricular (RV) dysfunction predicts poor outcome in patients (Pts) undergoing left ventricular assist device (LVAD) implantation but accurate quantification of RV dysfunction by...
Conclusions not supported by data
Authors: J. Temple
Journal: BMJ (1995)

Ophthalmologists is more helpful and avoids confusion.This states: The minimal visual field for safe driving is a field of vision of at least 120 degrees on the horizontal measured by the Goldmann perimeter using the III4e settings (or equivalent perimetry).In addition there should be no significant field defect in the binocular field which encroaches within 20 degrees of fixation either above or below the horizontal meridian.By these means homonymous or bitemporal defects which come close to fixation, whether hemianopic or quadrantanopic, are not accepted as safe for driving.Isolated scotomata represented in the binocular field near to the central fixation area may also be inconsistent with safe driving.2This definition is incorporated in the forthcoming revised edition of the booklet Medical Aspects of Fitness to Drive3 and is thought to be the best interpretation of the standard as it is applied to individual patients.
Prodromal symptoms in panic disorder with agoraphobia
Authors: G A Fava, S Grandi, R Canestrari
Journal: American Journal of Psychiatry (1988)

Of 20 patients suffering from panic disorder with agoraphobia, 18 reported experiencing agoraphobic avoidance, generalized anxiety, and/or hypochondriacal fears and beliefs before the first panic attack. The prevalence of these symptoms in the patients was significantly higher than the prevalence in 20 healthy control subjects. The results indicate that phobic avoidance in panic disorder with agoraphobia may not be secondary to the panic attacks, a finding that runs counter to the current DSM-III-R classification of anxiety disorders.
Increasing response rates to postal questionnaires
Authors: C. P Iglesias
Journal: BMJ (2002)

Editor—The systematic review by Edwards et al is helpful to those of us who routinely design and use questionnaires in our research.1 One area not covered by the review, which is important, is the quality of the response.

Response rates are clearly important, but the quality of the responses is also important in that returned questionnaires with some questions either missing or incorrectly filled in will have the same effect as a poor response. In a pilot study of questionnaires for a trial among people with venous ulcers one of us (CPI) noticed that many items on the SF12 were either missed or incorrectly completed. The questions that were missed were those within the stem and leaf format of the SF12; questions in a self contained format were not missed.

We therefore changed the layout of the questionnaire by altering all the stem and leaf questions to self contained ones. We then tested the revised version in a randomised trial among 1500 women aged 70 or over.2 The rates of questionnaires returned did not differ, but there was a large difference in the proportion of missing or incorrectly completed questions.

Thus 26.6% of women missed or incorrectly completed at least one item in the standard version of the SF12 compared with only 8.5% for the revised version (difference = 18.1%, 95% confidence interval 11.1% to 25.1%). The quality of the revised version was tested in a factor analysis, which showed that it had similar internal reliability to the standard version. In short, therefore, attention should be given to factors that improve the quality of responses as well as to response rates.
Increase of hormone-dependent cancer incidence in population under the age of forty
Authors: M. Gamulin, A. Znaor, A. Fucic
Journal: Journal of Clinical Oncology (2008)

1518 Background: Due to the synthesis and introduction of new compounds over the last few decades, environmental human exposure has been increasingly complex. In these settings, some xenobiotics express oestrogen-like activity. As these compounds are present in the living environment and diet, exposure starts in utero and continues over the childhood with still unknown health effects in the adulthood. Methods: Based on recently published data on increased breast cancer incidence in women under the age of forty (Bouchardy, 2007) we analysed age-specific breast and testicular cancer incidence rates in Croatia for the period between 1994 and 2005. Additionally to crude rates age-standardized rates were defined (World population) for age groups 25–54 years for breast cancer and 20–54 years for testicular cancer. Results: Age-standardized breast cancer incidence rates increased by 21% (from 55.55 per 100,000 women in 1994 to 67.39 per 100,000 women in 2005.). Increase was even more pronounced in population with testicular cancer; age-standardized incidence rates increased by 278% (from 3.39 per 100,000 men in 1994 to 12.83 per 100,000 men in 2005). In both cancer groups, the increase was significantly greater in younger patients (under the age of 35) than in older patients (35–54 years) (p=0.023 for breast cancer and p<0.001 for testicular cancer, chi-square test). Conclusions: In conclusion, breast and testicular cancer incidence in Croatia is on the rise, which is significantly pronounced in the population younger than 35 years. The increased hormone-dependent cancer incidence in younger population may be a consequence of complex environmental exposure, additionally burdened by xenoestrogens. Our findings urge further research. In case of breast cancer, preventive screening should include younger population in order to adjust health care policies to the actual dynamics of cancer incidence. No significant financial relationships to disclose.
Abstract 14218: Soluble Vascular Endothelial Growth Factor Receptor-1 Serves as a Marker of Cardiovascular Risk in Chronic Kidney Disease Patients
Authors: Hiromichi Wada, Shuichi Ura, Nobutoyo Masunaga, Masaharu Akao, Mitsuru Abe, Junko Funatsu, Yasuyo Nakajima, Mikihiko Kanasaki, Tameo Nakano, Koh Ono, Tatsuya Morimoto, Akira Shimatsu, Koji Hasegawa
Journal: Circulation (2011)

Background: Vascular endothelial growth factor (VEGF) plays a key role not only in angiogenesis but also in endothelial integrity. The soluble form of VEGF receptor-1 (sVEGFR-1/sFlt-1) is an endoge...
T-Cell Engineering For “off-The-shelf” Adoptive Immunotherapy
Authors: Laurent Poirot, Cécile Schiffer-Mannioui, Brian Philip, Sophie Derniame, Agnes Gouble, Isabelle Chion-Sotinel, Diane Le Clerre, Laetitia Lemaire, Stéphanie Grosse, Gordon Cheung, Sylvain Arnould, Julianne Smith, Martin Pule, Andrew Scharenberg
Journal: Blood (2013)