AB1648-PARE CROSS-SECTIONAL STUDY ON THE IMPACT OF SYMPTOMATIC OSTEOARTHRITIS ON SLEEP QUALITY
Authors: Y. Henrotin, P. Acker, M. Zwingelstein, C. Mathy
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Osteoarthritis (OA) affects 560 million people worldwide. It is essentially age-related and is the main cause of impaired quality of life in adults over the age of 40 [1]. Recently, the "STOP ARTHROSE II" survey on the main consequences of OA on patients' quality of life revealed that 50% of participants said they had difficulty falling asleep, and 67.6% woke up at night because of their pain [2]. <h3>Objectives:</h3> This cross-sectional study looked at the factors affecting sleep quality in subjects suffering from OA. <h3>Methods:</h3> This cross-sectional study including 295 French and Belgian participants was conducted online between January and April 2023. The questionnaire comprised 55 items including socio-demographic data, characteristics and treatments of OA, sleep quality, and the impact of OA on sleep quality. Quantitative data were summarized as mean and standard deviation (SD) or median and interquartile range (IQR). Frequency tables were used for categorical variables. Mean values were compared using the non-parametric Mann-Whitney test. Correlation between variables was also studied using the Spearman or Pearson test. Results were considered significant at the 5% critical level (P&lt;0.05). <h3>Results:</h3> 295 questionnaires were collected. 120 were excluded because they were incomplete or because the diagnosis of OA had not been made by a doctor. A total of 175 questionnaires were analyzed. Of the respondents, 76% were women, and 24% were men. The mean age of the participants was 54.7 ± 11.6 years, and their BMI was 26.8 ± 4.4 kg/m<sup>2</sup>. The mean duration of OA symptoms was 9.47 ± 9.67 years, and pain intensity was rated as mild to moderate by 71.5% of participants. The main joints affected by OA were the spine (57.7%), knees (45.7%) and hips (33.1%), and 61.8% of participants reported suffering from more than one joint. 65% disclosed to have sleep disorders, 47.4% reported that pain disturbed sleep, and 32% that sleep disorders appeared with OA. 32% had difficulty falling asleep, 53.1% had difficulty finding a comfortable position and 47.4% had sleep disturbances due to pain. 40% took medication to relieve pain before going to sleep, and 19.2% took sleeping pills. Overall, patients with poor sleep quality (p = 0.042), difficulty finding a comfortable position in bed (p = 0.001), and difficulty falling asleep (P = 0.0035) had higher joint pain intensity. Pain intensity was inversely correlated with sleep duration (r = -0.15; p = 0.038). Similarly, patients with poor sleep quality (p = 0.0039) and sleep disorders (p = 0.0042) suffered from OA longer than others. When considering the location of osteoarthritis, hip and shoulder osteoarthritis were both associated with difficulties in finding a comfortable position in bed (p = 0.019). No association was found between OA of the spine and knee and sleep quality. Hip OA was also associated with a significant reduction in sleep time and more restless sleep. <h3>Conclusion:</h3> The intensity of OA pain has an impact on sleep quality and difficulties in finding a comfortable position in bed. OA of the hip, but not of the knee or spine, was associated with poor sleep quality. These observations suggest that better pain management before going to sleep would be a good strategy for improving sleep quality in patients with OA. <h3>REFERENCES:</h3> [1] GBD 2021 Osteoarthritis Collaborators. Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023 Aug 21;5(9):e508-e522. doi: 10.1016/S2665-9913(23)00163-7. [2] Henrotin Y, Mathy C, Alliot-Launois F, Grange L. Les patients arthrosiques ont besoin de changements dans leur prise en charge. Résultats de l'enquête Stop-Arthrose 2021. Rhumatos, 2022: 5: 23-29. <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>