tbuckley/cabot-search huggingface dataset:
Covered self-expandable metal stent for hemostasis of ruptured pseudoaneurysm caused by partial stent-in-stent method
Authors: Hideaki Kazumori, Masaki Onoe, Satoshi Ooya, Yasuhiko Ohno, Kousaku Kawashima
Journal: Endoscopy (2023)

Placement of a covered self-expandable metal stent (CSEMS) is useful for hemostasis in patients with hemobilia [1] [2]. Following SEMS placement with a partial stent-in-stent (PSIS) method, an SEMS is not generally used for hilar bile duct hemostatsis as this type of stent may cause contralateral biliary obstruction. This is the first reported case of pseudoaneurysm rupture caused by PSIS, in which hemostasis was subsequently achieved using a CSEMS.
Omental patch-assisted endoscopic closure of the transmural defect after endoscopic removal of a 40-mm gastric gastrointestinal stromal tumor
Authors: Renato Medas, Julia L. Gauci, Clarence Kerrison, Francesco Vito Mandarino, Anthony Whitfield, Nicholas G. Burgess, Michael J. Bourke
Journal: Endoscopy (2023)

A 55-year-old woman with a gastric subepithelial lesion (SEL) was referred for treatment. Endoscopic ultrasound (EUS) revealed a 38 × 31-mm hypoechogenic lesion, originating in the muscularis propria, suggestive of a gastrointestinal stromal tumor (GIST). Computed tomography excluded extramural or metastatic disease.
Does endoprosthesis design impact bleeding risk when using lumen-apposing metal stents for drainage of pancreatic fluid collections?
Authors: Shyam Varadarajulu
Journal: Endoscopy (2023)

Lumen-apposing metal stents (LAMSs) were the answer to an urgent plea made in 2008 by an endoscopic ultrasound (EUS) working group for the development of dedicated devices to treat symptomatic pancreatic fluid collections (PFCs) [11]. The Axios platform (Boston Scientific) was designed to simplify, streamline, and improve the procedural safety of EUS-guided PFC drainage. While initial studies reported high technical and clinical success rates, delayed bleeding was observed in some patients. It was hypothesized that, unlike double-pigtail plastic stents (DPPSs), which migrate towards the gastric lumen with resolution of the PFC, the LAMS with its rigid spikes at both ends could erode into adjacent vasculature and precipitate bleeding [22]. Consequently, recommendations were made for timely removal of the LAMS [33]; however, the problem has not been fully eliminated [44].
Diagnosis and treatment of Tropheryma whipplei infection in patients with inflammatory rheumatic disease: Data from the French Tw-IRD registry
Authors: Damien Caillet Portillo, Xavier Puéchal, Maëva Masson, Marie Kostine, Alexia Michaut, André Ramon, Daniel Wendling, Nathalie Costedoat-Chalumeau, Pascal Richette, Hubert Marotte, Justine Vix-Portet, Jean-Jacques Dubost, Sébastien Ottaviani, Gaël Mouterde, Anne Grasland, Aline Frazier, Vincent Germain, Fabienne Coury, Anne Tournadre, Martin Soubrier, Laurent Cavalie, Pauline Brevet, Laurent Zabraniecki, Bénédicte Jamard, Guillaume Couture, Laurent Arnaud, Christophe Richez, Yannick Degboé, Adeline Ruyssen-witrand, Arnaud Constantin
Journal: Journal of Infection (2023)

ObjectivesTropheryma whipplei infection can manifest as inflammatory joint symptoms, which can lead to misdiagnosis of inflammatory rheumatic disease and the use of disease-modifying antirheumatic drugs. We investigated the impact of diagnosis and treatment of Tropheryma whipplei infection in patients with inflammatory rheumatic disease.MethodsWe initiated a registry including patients with disease-modifying antirheumatic drugs -treated inflammatory rheumatic disease who were subsequently diagnosed with Tropheryma whipplei infection. We collected clinical, biological, treatment data of the inflammatory rheumatic disease, of Tropheryma whipplei infection, and impact of antibiotics on the evolution of inflammatory rheumatic disease.ResultsAmong 73 inflammatory rheumatic disease patients, disease-modifying antirheumatic drugs initiation triggered extra-articular manifestations in 27% and resulted in stabilisation (51%), worsening (34%), or improvement (15%) of inflammatory rheumatic disease. At the diagnosis of Tropheryma whipplei infection, all patients had rheumatological symptoms (mean age 58 years, median inflammatory rheumatic disease duration 79 months), 84% had extra-rheumatological manifestations, 93% had elevated C-reactive protein, and 86% had hypoalbuminemia. Treatment of Tropheryma whipplei infection consisted mainly of doxycycline plus hydroxychloroquine, leading to remission of Tropheryma whipplei infection in 79% of cases. Antibiotic treatment of Tropheryma whipplei infection was associated with remission of inflammatory rheumatic disease in 93% of cases and enabled disease-modifying antirheumatic drugs and glucocorticoid discontinuation in most cases.ConclusionsTropheryma whipplei infection should be considered in inflammatory rheumatic disease patients with extra-articular manifestations, elevated C-reactive protein, and/or hypoalbuminemia before disease-modifying antirheumatic drugs initiation or in inflammatory rheumatic disease patients with an inadequate response to one or more disease-modifying antirheumatic drugs. Positive results of screening and diagnostic tests for Tropheryma whipplei infection involve antibiotic treatment, which is associated with complete recovery of Tropheryma whipplei infection and rapid remission of inflammatory rheumatic disease, allowing disease-modifying antirheumatic drugs and glucocorticoid discontinuation.Fundingnone.
Effects of low molecular weight heparin, alone or combined with antithrombin III, on mortality, fibrin deposits and hemostatic parameters in endotoxin‐induced disseminated intravascular coagulation in rabbits
Authors: J. Hermida, R. Montes, M.C. Muñoz, J. Orbe, J.A. Páramo, E. Rocha
Journal: American Journal of Hematology (1999)
Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach
Authors: Rachel E. Young, Katherine M. Nelson, Samuel I. Hofbauer, Tara Vijayakumar, Mohamad-Gabriel Alameh, Drew Weissman, Charalampos Papachristou, Jason P. Gleghorn, Rachel S. Riley
Journal: Bioactive Materials (2023)

Ionizable lipid nanoparticles (LNPs) have gained attention as mRNA delivery platforms for vaccination against COVID-19 and for protein replacement therapies. LNPs enhance mRNA stability, circulation time, cellular uptake, and preferential delivery to specific tissues compared to mRNA with no carrier platform. However, LNPs are only in the beginning stages of development for safe and effective mRNA delivery to the placenta to treat placental dysfunction. Here, we develop LNPs that enable high levels of mRNA delivery to trophoblasts
A community-based child health and parenting intervention to improve child HIV testing, health, and development in rural Lesotho (Early Morning Star): a cluster-randomised, controlled trial
Authors: Mark Tomlinson, Marguerite Marlow, Jackie Stewart, Moroesi Makhetha, Tholoana Sekotlo, Sebuoeng Mohale, Carl Lombard, Lynne Murray, Peter J Cooper, Nathene Morley, Stephan Rabie, Sarah Gordon, Amelia van der Merwe, Gretchen Bachman, Xanthe Hunt, Lorraine Sherr, Lucie Cluver, Sarah Skeen
Journal: The Lancet HIV (2023)
Abrogation of the G2/M checkpoint as a chemosensitization approach for alkylating agents
Authors: Fengchao Lang, James A Cornwell, Karambir Kaur, Omar Elmogazy, Wei Zhang, Meili Zhang, Hua Song, Zhonghe Sun, Xiaolin Wu, Mirit I Aladjem, Michael Aregger, Steven D Cappell, Chunzhang Yang
Journal: Neuro-Oncology (2023)

The cell cycle is tightly regulated by checkpoints, which play a vital role in controlling its progression and timing. Cancer cells exploit the G2/M checkpoint, which serves as a resistance mechanism against genotoxic anticancer treatments, allowing for DNA repair prior to cell division. Manipulating cell cycle timing has emerged as a potential strategy to augment the effectiveness of DNA damage-based therapies.
Measuring prognostic awareness in patients with advanced cancer: a scoping review and interpretive synthesis of the impact of hope
Authors: Jean Mathews, Shaila Merchant, Jacqueline Galica, Michael J Palmer, Jennifer O’Donnell, Rachel Koven, Christopher Booth, Michael Brundage
Journal: JNCI Journal of the National Cancer Institute (2023)

Abstract Background Assessment of prognostic awareness (PA) in patients with advanced cancer is challenging because patient responses often indicate their hopes. The objectives of this scoping review were to summarize studies that measured PA in patients with advanced cancer and to synthesize data about how PA was measured and whether hope was incorporated into the measurement. Methods MEDLINE and Embase databases were searched from inception to December 14, 2021. Data regarding the impact of hope on assessment of PA were extracted when studies reported on patients’ beliefs about prognosis and patients’ beliefs about their doctor’s opinion about prognosis. An interpretive synthesis approach was used to analyze the data and to generate a theory regarding the incorporation of hope into the assessment of PA. Results In total, 52 studies representing 23 766 patients were included. Most were conducted in high-income countries and measured PA based on the goal of treatment (curable vs incurable). Five studies incorporated hope into the assessment of PA and reported that among patients who responded that their treatment goal was a cure, an average of 30% also acknowledged that their doctors were treating them with palliative intent. Interpretive synthesis of the evidence generated a trinary conceptualization of PA patients who are aware and accepting of their prognosis; aware and not accepting; and truly unaware. Each of these groups will benefit from different types of interventions to support their evolving PA. Conclusion The trinary conceptualization of PA may promote understanding of the impact of hope in the assessment of PA and guide future research.
Advancing the Science and Application of Implementation Science to Promote Health Equity: Commentary on the Symposium
Authors: Rachel C. Shelton, Ross C. Brownson
Journal: Annual Review of Public Health (2023)

There has been an increasing focus on making health equity a more explicit and foundational aspect of the research being conducted in public health and implementation science. This commentary provides an overview of five reviews in this Annual Review of Public Health symposium on Implementation Science and Health Equity. These articles reflect on and advance the application of core implementation science principles and concepts, with a focus on promoting health equity across a diverse range of public health and health care settings. Taken together, the symposium articles highlight critical conceptual, methodological, and empirical advances in the study designs, frameworks, and approaches that can help address equity considerations in the use of implementation science in both domestic and global contexts. Finally, this commentary highlights how work featured in this symposium can help inform future directions for rapidly taking public health to scale, particularly among systemically marginalized populations and communities.
Embedded 3D Bioprinting of Collagen Inks into Microgel Baths to Control Hydrogel Microstructure and Cell Spreading
Authors: Lucia G. Brunel, Fotis Christakopoulos, David Kilian, Betty Cai, Sarah M. Hull, David Myung, Sarah C. Heilshorn
Journal: Advanced Healthcare Materials (2023)

Microextrusion-based 3D bioprinting into support baths has emerged as a promising technique to pattern soft biomaterials into complex, macroscopic structures. It is hypothesized that interactions between inks and support baths, which are often composed of granular microgels, can be modulated to control the microscopic structure within these macroscopic-printed constructs. Using printed collagen bioinks crosslinked either through physical self-assembly or bioorthogonal covalent chemistry, it is demonstrated that microscopic porosity is introduced into collagen inks printed into microgel support baths but not bulk gel support baths. The overall porosity is governed by the ratio between the ink's shear viscosity and the microgel support bath's zero-shear viscosity. By adjusting the flow rate during extrusion, the ink's shear viscosity is modulated, thus controlling the extent of microscopic porosity independent of the ink composition. For covalently crosslinked collagen, printing into support baths comprised of gelatin microgels (15-50 µm) results in large pores (≈40 µm) that allow human corneal mesenchymal stromal cells (MSCs) to readily spread, while control samples of cast collagen or collagen printed in non-granular support baths do not allow cell spreading. Taken together, these data demonstrate a new method to impart controlled microscale porosity into 3D printed hydrogels using granular microgel support baths.
Addressing Social Needs in Clinical Settings: Implementation and Impact on Health Care Utilization, Costs, and Integration of Care
Authors: Emmeline Chuang, Nadia Safaeinili
Journal: Annual Review of Public Health (2023)

In recent years, health care policy makers have focused increasingly on addressing social drivers of health as a strategy for improving health and health equity. Impacts of social, economic, and environmental conditions on health are well established. However, less is known about the implementation and impact of approaches used by health care providers and payers to address social drivers of health in clinical settings. This article reviews current efforts by US health care organizations and public payers such as Medicaid and Medicare to address social drivers of health at the individual and community levels. We summarize the limited available evidence regarding intervention impacts on health care utilization, costs, and integration of care and identify key lessons learned from current implementation efforts.
Long-term outcomes of pulmonary embolism in children and adolescents
Authors: Denise Bastas, Leonardo R. Brandão, Jennifer Vincelli, David Wilson, Lucy Perrem, Vitor Guerra, Gina Wong, Robert F. Bentley, Soumitra Tole, Jane E. Schneiderman, Nour Amiri, Suzan Williams, M. Laura Avila
Journal: Blood (2023)
Advances in Microfluidic Technologies in Organoid Research
Authors: Haitao Liu, Zhongqiao Gan, Xinyuan Qin, Yaqing Wang, Jianhua Qin
Journal: Advanced Healthcare Materials (2023)

Organoids have emerged as major technological breakthroughs and novel organ models that have revolutionized biomedical research by recapitulating the key structural and functional complexities of their in vivo counterparts. The combination of organoid systems and microfluidic technologies has opened new frontiers in organoid engineering and offers great opportunities to address the current challenges of existing organoid systems and broaden their biomedical applications. In this review, the key features of the existing organoids, including their origins, development, design principles, and limitations, are described. Then the recent progress in integrating organoids into microfluidic systems is highlighted, involving microarrays for high-throughput organoid manipulation, microreactors for organoid hydrogel scaffold fabrication, and microfluidic chips for functional organoid culture. The opportunities in the nascent combination of organoids and microfluidics that lie ahead to accelerate research in organ development, disease studies, drug screening, and regenerative medicine are also discussed. Finally, the challenges and future perspectives in the development of advanced microfluidic platforms and modified technologies for building organoids with higher fidelity and standardization are envisioned.
Assessment and comparative analysis of renal function parameters in patients with liver cirrhosis and atrial fibrillation
Authors: A.E. Baylo, V.V. Cherniavskyi, L.S. Hvozdetska, V.V. Tishchenko, D.O. Reshotko
Journal: GASTROENTEROLOGY (2023)

Background. Currently, there is insufficient scientific data on renal function in patients with comorbid course of liver cirrhosis (LC) and atrial fibrillation (AF), as well as the effect of anticoagulant treatment on kidney function in these patients. The aim of the study is assessment and comparison of renal function parameters in patients with liver cirrhosis and atrial fibrillation before and after warfarin and dabigatran treatment during three months. Materials and methods. A randomized clinical trial with a 2-stage design was conducted. At the I stage, 106 patients took part in the study: 70 of them with a comorbid course of LC and AF, 36 with LC alone. At the II stage, 56 people with LC and AF received warfarin and dabigatran for three months. A comparative assessment of creatinine, blood urea nitrogen (BUN), glomerular filtration rate (GFR) before and after treatment was carried out. Results and discussion. In patients with LC and AF, renal dysfunction is more severe due to deterioration of creatinine, BUN and GFR compared to those with LC alone (p &lt; 0.05). Warfarin treatment of patients with LC and AF is characterized by a statistically significant worsening of creatinine, BUN and GFR (р &lt; 0.05). On the other hand, in the group of patients with LC and AF treated with dabigatran, these paraments do not differ significantly from the baseline values (р &gt; 0.05). Conclusions. Patients with the comorbid pathology of LC and AF have statistically worse renal function parameters compared to individuals with LC alone. After treatment of patients with LC and AF with anticoagulant drugs for three months, functional kidney parameters significantly worsened compared to those before treatment. Warfarin treatment of patients with LC and AF is characterized by a statistically significant worsening of creatinine, BUN and GFR compared to dabigatran-treated patients.
Endoscopic ultrasonography in diagnosis of digestive diseases. Review of clinical cases
Authors: Yu.M. Stepanov, N.V. Prolom, S.O. Tarabarov, M.V. Titova, I.M. Adamska, O.V. Zeleniuk
Journal: GASTROENTEROLOGY (2023)

Endoscopic ultrasound (EUS) is a high-tech ultrasound examination that simultaneously combines the options of endoscopic and ultrasound diagnosis of diseases of the gastrointestinal tract, pancreas, bile ducts and liver. The advantages of endoscopic ultrasound over traditional transabdominal ultrasound are that the ultrasound transducer can be guided directly through the lumen of the gastrointestinal tract to the object under visual control. The EUS is the method of choice for the study of submucosal lesions in the upper gastrointestinal tract. It is the most accurate method for the detection and diagnosis of submucosal formations due to its high sensitivity, specificity, is used as the next research method after endoscopy and can provide information about the origin, size, borders, homogeneity, as well as the choice of treatment method: endoscopic or surgical one. A more important application of EUS is the determination of the stage of malignant neoplasms of the gastrointestinal tract, as it determines the treatment and predicts the disease. And the real-time strain elastography, which allows analyzing the stiffness of tissues, helps in this. The high accuracy of this study allows for the differential diagnosis of benign and malignant neoplasms. The article presents cases of examination of patients with submucosal neoplasms of the stomach who were treated in the SI “Institute of Gastroentero­logy of the National Academy of Medical Sciences of Ukraine”.
A systematic review of studies on the effectiveness of biosuggestive therapy in the correction of psychosomatic disorders: focus on disorders of the gut-brain interaction
Authors: O.Yu. Gubska, V.V. Alekseeva, O.V. Dudko, A.A. Kuzminets, O.M. Bozhitska, B.R. Maftychuk
Journal: GASTROENTEROLOGY (2023)

Background. The increasing pace of modern life, the pandemic, the war in Ukraine, the presence of somatic pathology and mental states are interconnected and have a direct cause and effect relationship. Psychological distress is often experienced as physical symptoms. Psychotherapeutic and psychocorrective methods recommended by the Rome Committee have become the standard of therapy for patients with functional gastrointestinal disorders or, according to modern terminology, disorders of the gut-brain interaction (DGBI). In adjustment disorders and many neurotic disorders against the background of chronic distress, psychocorrection, cognitive behavioral and other types of psychotherapy play an important role in addition to pharmacological correction. The method of biosuggestive therapy (BST) is the successor of hypnotherapy in Ukraine and, as an effective non-pharmacological psychocorrective approach, has recently gained considerable popularity in the correction of psychological disorders. The goal of our research was to analyze all publications available in 2023 on the experience of using and the results of the effectiveness of the BST as a method of intestinal-directed therapy, and in other clinical situations researched and published in the scientific literature. Discussion. As a result of our analysis, 21 works were selected that were presented in Ukrainian and foreign publications regarding the effectiveness of the biosuggestive therapy. When BST is used in patients with functional gastrointestinal disorders or DGBI, a decrease in the manifestations of the disease was noted in addition to a decrease in the severity of mental disorders. In forcibly displaced persons from the ATO zone and during military operations in Ukraine, the use of BST in chronic pain led to a decrease in symptoms of anxiety and depression, the level of stress and an increase in general well-being in stress-related conditions. The BST showed a reduction in behavioral disorders in children and adults. Conclusions. The BST method can be used to correct various psychosomatic and stress-related disorders, combined with functional and chronic diseases, endocrine pathology, behavioral problems of childhood and adolescence. The use of BST as a branch of gut-directed hypnotherapy needs further research with regard to different manifestations of DGBI, which will be presented in the near future.