tbuckley/cabot-search huggingface dataset:
Abstract 17974: Prognostic Impact After Acute Kidney Injury in Patients with Acute Heart Failure: An evaluation of the RIFLE Criteria
Authors: Akihiro Shirakabe, Noritake Hata, Takuro Shinada, Nobuaki Kobayashi, Kazunori Tomita, Mitsunobu Kitamura, Masato Matsushita, Kuniya Asai, Kyoichi Mizuno
Journal: Circulation (2011)

Background: The clinical course and the outcome of acute heart failure (AHF) are known to correlate with renal dysfunction. However, the evaluation of renal dysfunction, especially acute kidney injury (AKI), has not yet been standardized. This study, therefore, investigated the relationship between the short term and long term prognosis of AHF and AKI using the risk, injury, failure, and end stage (RIFLE) criteria. Methods and Results: This study analyzed seven hundred ten patients with AHF who were admitted to the intensive care unit. The most severe RIFLE classifications during hospitalization were adopted to assess the patient outcome. The AHF patients were assigned to no AKI (n=244), Class R (risk; n=259), Class I (injury; n=106), and Class F (failure; n=101). This study evaluated the relationships between the RIFLE classifications and in-hospital mortality, cardiovascular death and HF events including cardiovascular death, and readmission to the hospital for HF within 2 years. The results of the multivariate logistic regression model for in-hospital mortality found that the specific factors were Class I (p=0.005, hazard ratio: 4.01; 95% CI: 1.51-10.69) and Class F (p&lt;0.001, hazard ratio: 10.64; 95% CI: 4.21-26.90). Furthermore, Class I and Class F were independently associated with cardiovascular death (Class I p=0.006, hazard ratio: 2.49; 95% CI: 1.31-4.75, Class F p&lt;0.001, hazard ratio: 5.42; 95% CI: 2.84-10.35) and Class F were independently associated with HF events (p&lt;0.001, hazard ratio: 3.09; 95% CI: 1.76-5.43). The Kaplan-Meier survival curves showed the prognosis including cardiovascular death to be significantly poorer among the patients with Class I and Class F in comparison to no-AKI and Class R (p&lt;0.001, Log-Rank test), and the prognosis including HF events to be significantly poorer among the patients with Class F in comparison to no-AKI, Class R and Class I (p&lt;0.001, Log-Rank test). Conclusions: The presence of severe AKI (Class I and F) was found to be independently associated with both short-term and long-term mortality in patients with AHF, however, mild AKI (Class R) and no AKI were not associated with those events. The RIFLE criteria should therefore be developed into a clinically applicable and standardized method for AHF patients.
Abstract 629: 3D Integration of Intracardiac Echocardiography and Multi-Slice Computed Tomography to Facilitate Radiofrequency Catheter Ablation for Atrial Fibrillation
Authors: Dennis W den Uijl, Laurens F Tops, Jose M Tolosana, Serge A Trines, Katja Zeppenfeld, Jeroen J Bax, Martin J Schalij
Journal: Circulation (2008)
Hodgkin Disease/Lymphoma Clinical Practice Guidelines
Authors: Richard T. Hoppe, Ranjana Hira Advani, Philip Jay Bierman, Clara D. Bloomfield, Francis Buadi, Benjamin Djulgegovic, Andres Forero, Leo I. Gordon, Francisco J. Hernandez-Ilizaliturri, Mark S. Kaminski, Gena Love, David G. Maloney, Peter M. Mauch, Joseph O. Moore, Russell J. Schilder, Lawrence Weiss, Jane N. Winter, Joachim Yahalom, Andrew D. Zelenetz
Journal: Journal of the National Comprehensive Cancer Network (2006)

Cure rates for Hodgkin disease/lymphoma have increased to such an extent that the overriding treatment considerations often relate to long-term toxicity, especially for patients with early- or intermediate-stage disease. Current management programs are based on comprehensive clinical staging followed by combined modality therapy for patients with favorable and intermediate prognosis, or chemotherapy alone for patients with advanced disease. Relapse is uncommon, but secondary management with peripheral stem cell transplantation may be effective. The excellent prognosis for these patients mandates careful long-term follow-up to detect late treatment effects. For the most recent version of the guidelines, please visit NCCN.org
AMERICAN MEDICINE IN WAR AND PEACE
Authors: Ernest E. Irons
Journal: Annals of Internal Medicine (1944)

Article1 May 1944AMERICAN MEDICINE IN WAR AND PEACEERNEST E. IRONS, M.D., F.A.C.P.ERNEST E. IRONS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-5-738 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe are at war and every power of the College of Physicians is mobilized in assistance of the war effort. We accept without question the limitations on medical and other activities made necessary by the exigencies of war. Our first consideration is the winning of the war; our present effectiveness, however, is conditioned by our educational preparation in past years.Throughout its entire history, the purpose of the College of Physicians has included the improvement of standards of education and of the quality of performance of physicians. Our annual meetings have been primarily educational. Fellowships and awards have been established... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Inaugural Address as President of the American College of Physicians, delivered before the Annual Dinner Meeting, Chicago, April 1, 1944. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1944Volume 20, Issue 5Page: 738-742KeywordsFellowships ePublished: 1 December 2008 Issue Published: 1 May 1944 PDF downloadLoading ...
The National Cardiovascular Data Registry (NCDR) Data Quality Brief
Authors: John C. Messenger, Kalon K.L. Ho, Christopher H. Young, Lara E. Slattery, Jasmine C. Draoui, Jeptha P. Curtis, Gregory J. Dehmer, Frederick L. Grover, Michael J. Mirro, Matthew R. Reynolds, Ivan C. Rokos, John A. Spertus, Tracy Y. Wang, Stuart A. Winston, John S. Rumsfeld, Frederick A. Masoudi
Journal: Journal of the American College of Cardiology (2012)
Genetic Alterations in Colorectal Cancer Have Different Patterns on 18F-FDG PET/CT
Authors: Shang-Wen Chen, Chien-Yu Lin, Cheng-Man Ho, Ya-Sian Chang, Shu-Fen Yang, Chia-Hung Kao, Jan-Gowth Chang
Journal: Clinical Nuclear Medicine (2015)

The aim of this study was to understand the association between various genetic mutation and (18)F-FDG PET-related parameters in patients with colorectal cancer (CRC).One hundred three CRC patients who had undergone preoperative PET/CTs were included in this study. Several PET/CT-related parameters, including SUV(max), and various thresholds of metabolic tumor volume, total lesion glycolysis, and PET/CT-based tumor width (TW) were measured. Using high-resolution melting methods for genetic mutation analysis, tumor- and PET/CT-related parameters were correlated with various genetic alterations including TP53, KRAS, APC, BRAF, and PIK3CA. Mann-Whitney U test and logistic regression analysis were carried out for this analysis.Genetic alterations in TP53, KRAS, and APC were found in 41 (40%), 34 (33%), and 27 (26%) of tumors, respectively. PIK3CA and BRAF were exhibited by 5 and 4 of the patients with CRC. TP53 mutants exhibited higher SUV(max). The odds ratio was 1.28 (P = 0.04; 95% confidence interval, 1.01-1.61). Tumors with a mutated KRAS had an increased accumulation of FDG using a 40% threshold level for maximal uptake of TW (TW(40%)), whereas the odds ratio was 1.15 (P = 0.001; 95% confidence interval, 1.06-1.24). The accuracy of SUV(max) greater than 10 in predicting TP53 mutation was 60%, whereas that for TW(40%) for KRAS was 61%.Increased SUV(max) and TW(40%) were associated in CRC tumors with TP53 and KRAS mutations, respectively. Further studies are required because of the low predictive accuracy.
Gene expression module associated with Insulin-like Growth Factor 1 (IGF1) pathway activation predicts poor response to tamoxifen in women with ER+/HER2- early breast cancer (BC)
Authors: Michail Ignatiadis, Benjamin Haibe-Kains, Philippe L Bedard, Sandeep Singhal, Françoise Lallemand, Christine Desmedt, Fatima Cardoso, Martine Piccart-Gebhart, Christos Sotiriou
Journal: Cancer Research (2009)

Background: Insulin-like Growth Factor 1 (IGF1) signaling has been shown to be crucial for tumor transformation and survival of malignant cells. In BC, IGF1 pathway activation was related to tamoxifen resistance in estrogen receptor (ER)-positive cell lines and in vivo mouse models. In this present study, we sought to investigate the clinical relevance of IGF1 pathway activation in a large homogenous data set of ER+/HER2- BC patients with well-annotated microarray data and long clinical follow-up. Material and Methods: The IGF1 pathway module was developed in silico by selecting genes that were specifically correlated with the expression levels of IGF1 gene without looking at gene annotation and clinical outcome. The association between IGF1 module and clinical outcome was investigated using several publicly available datasets including 590 systemically untreated and 383 tamoxifen only treated node negative and node positive ER+/HER2- early BC patients. Low (luminal A) vs high (luminal B) proliferative ER+/HER2- BC subtypes were defined based on the Genomic Grade Index (GGI). Results: IGF1 module was composed of 142 IGF1 pathway related genes. IGF1 pathway activation was significantly associated with high-proliferative ER+/HER2- tumors (luminal B). In the van de Vijver and Wang datasets, the IGF1 module demonstrated a significant correlation (Pearson correlation 0.619 and 0.601, respectively) with an IGF1 signature developed by in vitro IGF1 stimulation of MCF7 cells lines (Creighton et al JCO 2008). IGF1 pathway activation was associated with worse distant metastasis free survival (DMFS) in systemically untreated and tamoxifen-only treated women with ER+/HER2- BC (P  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 2743.
Beneficial effects of weight loss associated with a high protein diet on cardiovascular risk profile, functional status and quality of life in obese heart failure patients: A feasibility study
Authors: Lorraine S Evangelista, David Heber, Zhaoping Li, Michele Hamilton, Gregg C Fonarow
Journal: Circulation (2007)

CLINICAL SCIENCE Abstract 1818: Beneficial Effects of Weight Loss Associated with a High Protein Diet on Cardiovascular Risk Profile, Functional Status and Quality of Life in Obese Heart Failure Patients: A Feasibility Study Lorraine S Evangelista, David Heber, Zhaoplng U, Michele Hamllton and Gregg C Fonarow Published: October 16, 2007 Article Figures & Tables Info & Metrics eLetters .., Jumpto Abstract OBJECTIVE: Clinical management of chronic heart failure (HF) related to adequate nutritional intake currently lacks a strong scientific basis. This study was conducted to evaluate the impact of 3 diet interventions on body weight and its potential to reduce cardiovascular risks and improve functional status. METHOD: Fourteen obese HF patients (BMI > 27 kg/m2) were randomized to1 of 3 diets: high protein (HP); low fat (LF) or average diet/control group (CG). Body anthropometrics (weight, BMI, waist circumference), indices of cardiovascular risks including (% body fat, blood pressure, cholesterol, triglycerides), and measures of functional status (6-minute walk, max V02) were obtained at baseline and after a 12-week nutritional support program. Statistics included two-way RMANOVA. RESULTS: There were no significant differences in age (59±10 years), gender (78% male), NYHA (43% class II; 57% class Ill), HF etiology (57% non-ischemic), or ejection fraction (0.26±0.07) between the groups. The HP diet resulted in moderate reductions in bodyweight (FigureU) and improvements in several health parameters (Table~).
Analyses of the Post-reflux Swallow-induced Peristaltic Wave Index and Nocturnal Baseline Impedance Parameters Increase the Diagnostic Yield of Impedance-pH Monitoring of Patients With Reflux Disease
Authors: Marzio Frazzoni, Edoardo Savarino, Nicola de Bortoli, Irene Martinucci, Manuele Furnari, Leonardo Frazzoni, Vincenzo Giorgio Mirante, Helga Bertani, Santino Marchi, Rita Conigliaro, Vincenzo Savarino
Journal: Clinical Gastroenterology and Hepatology (2015)
Consensus Meeting on New Approaches in the Pharmacotherapy of Benign Prostatic Hyperplasia (BPH)
Authors: A. Jardin, K.E. Andersson, C.C. Schulman, D. Graham, S. Arbilla, C. Pimoule, S.Z. Langer, J.M. Buzelin, J.M.C.H. de la Rosette, T.J. Chrismas, C.R. Chapple
Journal: European Urology (1996)
Characterization of the Underlying Molecular Defect in Hereditary Spherocytosis Associated With Spectrin Deficiency
Authors: H. Hassoun, J.N. Vassiliadis, J. Murray, P.R. Njolstad, John J. Rogus, S.K. Ballas, F. Schaffer, P. Jarolim, V. Brabec, J. Palek
Journal: Blood (1997)
Abstract 2052: Long term Patency of Decellularized Vascular Grafts in a Canine Model
Authors: Alan P Kypson, Juliana L Blum, Yuling Li, Justin T Strader, Tiare P Williams, M T Hensley, Laura E Niklason, Shannon L Dahl
Journal: Circulation (2007)

Cryopreserved and synthetic vascular conduits have limitations to their widespread adoption while the demand for suitable alternatives to native vascular conduits will increase. Tissue engineering ...
Feasibility of hand-assisted laparoscopic surgery (HALS) in gynecologic oncology patients
Authors: W. A. Spannuth, R. P. Rocconi, J. M. Straughn, W. K. Huh, M. N. Barnes
Journal: Journal of Clinical Oncology (2005)

5153 Objective: Although hand-assisted laparoscopic surgery (HALS) has been utilized in multiple surgical procedures, limited data exists on the use of HALS for gynecologic oncology indications. Our goal was to evaluate the indications, potential benefits, and complications of HALS in cases of suspected gynecologic malignancy. Methods: We performed a retrospective chart review of patients who had an HALS procedure performed from 1/03 until 10/04. Data was collected on patient demographics, indications for surgery, operative morbidity, and length of stay. Results: 37 patients who underwent a HALS procedure were identified. The median age was 51 years (range, 19–86) and the mean BMI was 28.7 m2 (range, 17.8–40.7). The indications for surgery included pelvic mass (n=29), prophylactic oophorectomy (n=2), secondary cytoreduction for ovarian cancer (n=2), uterine fibroids (n=2), surgical staging for endometrial cancer (n=1), post-menopausal bleeding (n=1), and vaginal vault prolapse (n=1). The mean estimated size of pelvic mass removed was 11.2 cm (range, 3–30). 6 of 29 (21%) patients with a pelvic mass were diagnosed with an ovarian carcinoma. All patients underwent general endotracheal anesthesia for the following procedures performed: oophorectomy (n=31), lysis of adhesions (n=14), surgical staging (n=9), hysterectomy (n=9), loop colostomy (n=1), and sacrocolpo suspension (n=1). Mean operating time was 90 minutes (range, 46–157) with mean estimated blood loss of 110 cc (range, 10–400). One patient was converted to laparotomy due to a large unresectable mass. One intraoperative complication of epigastric vessel injury due to trocar placement occurred. The average length of post-operative hospital stay was 2.8 days (range, 2–5). 4 of 37 (11%) patients experienced a post-operative complication including ileus (n=2), pre-renal azotemia (n=1), and transfusion of packed red blood cells (n=1). Conclusions: HALS is an innovative surgical technique that allows a number of surgical procedures to be accomplished in gynecologic oncology patients. HALS appears to be safe and feasible based on acceptable operating time, estimated blood loss, conversion rate, complication rate, and length of hospital stay. No significant financial relationships to disclose.
Overcoming racism in the NHS
Authors: N. Turner, R. Bedi, U. M MacFadyen
Journal: BMJ (1997)

Objective: To quantify the effectiveness and safety of corticosteroids in the treatment of acute traumatic brain injury.Design: Systematic review of randomised controlled trials of corticosteroids in acute traumatic brain injury.Summary odds ratios were estimated as an inverse variance weighted average of the odds ratios for each study.Setting: Randomised trials available by March 1996.Subjects: The included trials with outcome data comprised 2073 randomised participants. Results:The effect of corticosteroids on the risk of death was reported in 13 included trials.The pooled odds ratio for the 13 trials was 0.91 (95% confidence interval 0.74 to 1.12).Pooled absolute risk reduction was 1.8% ( -2.5% to 5.7%).For the 10 trials that reported death or disability the pooled odds ratio was 0.90 (0.72 to 1.11).For infections of any type the pooled odds ratio was 0.92 (0.69 to 1.23) and for the seven trials reporting gastrointestinal bleeding it was 1.05 (0.44 to 2.52).With only those trials with the best quality of concealment of allocation, the pooled odds ratio estimates for death and death or disability became closer to unity.Conclusions: This systematic review of randomised controlled trials of corticosteroids in acute traumatic brain injury shows that there remains considerable uncertainty over their effects.Neither moderate benefits nor moderate harmful effects can be excluded.The widely practicable nature of the drugs and the importance of the health problem suggest that large simple trials are feasible and worth while to establish whether there are any benefits from use of corticosteroids in this setting.
Abstract 18220: High-intensity Interval Training Reduces P53 Expression and Increases Telomerase Activity in Circulating Mononuclear Cells of Untrained Subjects
Authors: Christian Werner, Maxi Hauser, Tim Meyer, Michael Boehm, Ulrich Laufs
Journal: Circulation (2012)

Aim:  In athletes, vigorous long-term endurance training is associated with increased telomerase activity and prevention of age-dependent telomere erosion and p53 up-regulation in circulating mononuclear cells. We examined whether high-intensity interval running exercise activates cellular anti-senescent pathways in untrained healthy subjects. Methods and Results: N=10 untrained healthy subjects with normal aerobic exercise capacity (age 44±3 years, BMI 24±3kg/m2, VO2max 38±7ml/min*kg) were subjected to a supervised high-intensity interval running exercise for 3 months. Before the first and after the last training, ECG and treadmill stress tests were performed to measure training status and maximal heart rate (maxHR). The training intervention consisted of three HR-controlled training sessions per week. After warm-up four intervals consisting of 4 minutes fast running at 80-90% maxHR interspersed by 3 minutes slow running at 65-75% maxHR were performed before cool-down. Peripheral blood mononuclear cells (MNC) were isolated by density gradient centrifugation before and after training. After three months training, MNC telomerase activity was increased (145±7%; p=0.04, TRAP assay). Protein expression of the senescence marker and apoptosis regulator p53 was reduced (68±23% vs. inclusion, p   Conclusion:  This pilot study suggests that a high-intensity interval training over three months leads to an increase in telomerase activity and a reduction in the expression of senescence markers in circulating blood cells in healthy subjects without prior training experience. In concert with previous studies, the findings set the stage to address the question which training modality, intensity and duration are optimal to exert vascular anti-aging effects and whether monocyte senescence proteins are useful markers to assess the preventive potential of a training intervention.
Abstract 19706: Increasing Survival and Decreasing Sudden Death Rate from Commotio Cordis
Authors: Barry Maron, Tammy Haas, Aneesha Ahluwalia, Ross Garberich, N.A. Mark Estes, Mark Link
Journal: Circulation (2012)

Introduction. Commotio cordis events due to precordial blows triggering ventricular fibrillation are a cause of sudden death (SD) in competitive and recreational sports and normal daily activities. Despite normal cardiac structure, these events have been considered predominantly fatal with survival rates of &lt; 20%. Hypothesis. To determine whether there has been a change in the expected mortality rate for commotio cordis over time, associated with (or due to) greater public visibility of this condition. Methods. U.S. Commotio Cordis Registry was accessed to tabulate the frequency of resuscitated cardiac arrest or SD from 1970 to 2012. Results. At the time of their commotio cordis event, 215 study patients were 1 to 50 years old, mean 15; 95% were male. Death due to commotio cordis occurred in 156 individuals (73%), and the other 59 (27%) survived. Notably, the proportion of commotio cordis survivors increased steadily with a concomitant decrease in fatal events over 43 years: for the first 24 years (1970-1993) only 6 of 59 survived (10%) while in the most recent 19 years (1994-2012), 53/156 (34%) survived (p &lt; 0.001). From 2006-2012, survival was 30/52 (58%), at which point the survivor and non-survivor curves crossed (Figure). Survival from commotio cordis was lower in African-Americans (1/24; 4%) compared to whites (53/165; 32%; p=0.007), and less common in recreational sports (16%)/daily activities (12%) than during competitive sports (39%; p &lt; 0.001). Multivariate analysis showed adverse independent predictors of survival to be black race (p=0.051), recreational sports (p=0.019), and daily activities (p=0.012), while the onsite use of AEDs was protective vs. SD (p=0.006). Conclusions. Survival from commotio cordis has become significantly more common, largely due to public access defibrillation and greater public awareness. Racial disparity in survival is a notable concern.