tbuckley/cabot-search huggingface dataset:
Proposal of the Physicians' Working Group for Single-Payer National Health Insurance
Authors: Steffie Woolhandler, David U Himmelstein, Marcia Angell, Quentin D Young
Journal: JAMA (2003)

The United States spends more than twice as much on health care as the average of other developed nations, all of which boast universal coverage. Yet more than 41 million Americans have no health insurance. Many more are underinsured. Confronted by the rising costs and capabilities of modern medicine, other nations have chosen national health insurance (NHI). The United States alone treats health care as a commodity distributed according to the ability to pay, rather than as a social service to be distributed according to medical need. In this market-driven system, insurers and providers compete not so much by increasing quality or lowering costs, but by avoiding unprofitable patients and shifting costs back to patients or to other payers. This creates the paradox of a health care system based on avoiding the sick. It generates huge administrative costs that, along with profits, divert resources from clinical care to the demands of business. In addition, burgeoning satellite businesses, such as consulting firms and marketing companies, consume an increasing fraction of the health care dollar. We endorse a fundamental change in US health care—the creation of an NHI program. Such a program, which in essence would be an expanded and improved version of traditional Medicare, would cover every American for all necessary medical care. An NHI program would save at least $200 billion annually (more than enough to cover all of the uninsured) by eliminating the high overhead and profits of the private, investor-owned insurance industry and reducing spending for marketing and other satellite services. Physicians and hospitals would be freed from the concomitant burdens and expenses of paperwork created by having to deal with multiple insurers with different rules, often designed to avoid payment. National health insurance would make it possible to set and enforce overall spending limits for the health care system, slowing cost growth over the long run. An NHI program is the only affordable option for universal, comprehensive coverage.
Incidental Neurofibroma on 18F-Fluorocholine PET/MR
Authors: Kanhaiyalal Agrawal, Rakesh S. Sajjan, Maria Gavra, Francesco Fraioli, Jamshed Bomanji, Rizwan Syed
Journal: Clinical Nuclear Medicine (2015)

Neurofibromas are benign peripheral nerve sheath tumors. We described a unique case of recurrent prostate cancer with coexisting neurofibroma diagnosed on 18F-fluorocholine PET/MRI.
The World Health Report 2012 That Wasn't
Authors: Virginia Barbour, Jocalyn Clark, Laureen Connell, Paul Simpson, Margaret Winker, Emma Veitch
Journal: PLoS Medicine (2012)

The PLOS Medicine editors comment on the history of the World Health Organization's latest World Health Report, originally planned for publication in 2012, and the outcomes of the journal's collaboration with WHO on the intended theme of no health without research.
Ongoing mumps outbreak in a student population with high vaccination coverage, Netherlands, 2010
Authors: J Whelan, R van Binnendijk, K Greenland, E Fanoy, M Khargi, K Yap, H Boot, N Veltman, C Swaan, A van der Bij, H de Melker, S Hahné
Journal: Eurosurveillance (2010)

Since December 2009, mumps incidence has increased in the Netherlands. As of 20 April 2010, 172 cases have been notified on the basis of laboratory confirmation or linkage to a laboratory-confirmed case. Of these, 112 were students, the majority of whom had been vaccinated (81%). Although outbreaks in vaccinated populations have been described before, risk factors for exposure and susceptibility, and dose-dependent vaccine effectiveness in a student population of this nature are relatively unknown.
Borderline and schizophrenic patients: A comparative study
Authors: J G Gunderson, W T Carpenter, J S Strauss
Journal: American Journal of Psychiatry (1975)

The authors describe the evaluation and follow-up of matched samples of borderline and schizophrenic patients to determine the ways that borderline disorders are similar to or different from schizophrenia. The borderline patients presented more confusing diagnostic pictures, but they could be differentiated from the schizophrenic patients by the absence of definite or prolonged psychotic episode, by the relative severity of their dissociative experiences, by more severe anger, and by less anxiety. Despite the discrepant symptom pictures of the two patient groups, a systematic review of prehospitalization functioning and two-year posthospitalization course did not reveal significant differences between them.
“正常”血糖与冠状动脉的危险性——量效作用似乎与糖血症的整个病程相一致
Authors: 李景东
Journal: BMJ (2002)

虽然糖尿病是冠心病的强危险因子 ,但是对于“正常血糖范围”内的糖血症与冠心病之间的关系仍然存在着一些争议1。在 1979年 ,一项 15个国家合作的研究报道 :在芬兰、丹麦、法国、英国和美国的男性中 ,血糖最高十分位与最低十分位的危险比为0 34%至 6 0 7%2 。而在其他队列研究中 ,包括白厅试验3 和弗明汉4试验 ,又发现似乎存在着一个阈值效应 ,即糖血症的危险性只在血糖水平接近或达到目前糖尿病的诊断标准时才显示出来。对以上矛盾的结果有几个可能的解释 ,包括 :未从队列中排除糖尿病病人 ,存在着相一致的阈值效应 ;冠心病的多种病因学 ,存在着模糊概念 ;或者是个体的葡萄糖水平(
Abstract 15465: Calpain Inhibition by Constitutive Calpastatin Overexpression Leads to Increased Mortality and More Severe Left Ventricular Dysfunction at Long Term After Myocardial Infarction in Mice
Authors: Feng Wan, Amal Houssaini, Pierre-Francois Lesault, Shariq Abid, Dominique Rideau, Olivier le Coz, Florence Canoui-Poitrine, Laurent Baud, Serge Adnot, Barnabas Gellen
Journal: Circulation (2011)

Introduction: Calpains play an essential role in left ventricular (LV) remodeling post myocardial infarction (MI). Its inhibition reduces LV dysfunction at short term post MI. We examined if calpai...
Pre-BCR Signaling Activity Predicts Sensitivity To Syk Kinase Inhibition In B Cell Acute Lymphoblastic Leukemia (B-ALL)
Authors: Stefan Koehrer, Richard E. Davis, Greg Coffey, Ekaterina Kim, Nathalie Y. Rosin, Elisa ten Hacken, Susan O'Brien, William G. Wierda, Zeev Estrov, Deborah A. Thomas, Hagop M. Kantarjian, Zhiqiang Wang, Hassan Jumaa, Jan A. Burger
Journal: Blood (2013)
磁共振成像脑白质高信号在临床上重要吗？是的，并且应该详细筛查卒中和痴呆的危险因素
Authors: Anders, Wallin, Tormod, Fladby, 廖怡, 李飞, 龚启勇, 付诗琴
Journal: BMJ (2010)

脑的小血管病是所有神经疾病中常见之一，经常发生，甚至在年轻健康的人群，导致神经退行性变、血管性认知障碍以及残疾。迄今为止，小血管病尚不能被直接检测。然而，典型的临床症状或者在影像上确诊的脑白质损伤，例如磁共振成像（MRI）上的脑白质高信号，都可被视作小血管病的替代性标记物。
Fourier-Domain Optical Coherence Tomography Imaging in Keratoconus
Authors: Otman Sandali, Mohamed El Sanharawi, Cyril Temstet, Taous Hamiche, Alice Galan, Wajdene Ghouali, Isabelle Goemaere, Elena Basli, Vincent Borderie, Laurent Laroche
Journal: Ophthalmology (2013)
Arginine Deprivation With Pegylated Arginine Deiminase Induces Death Of Acute Myeloid Leukaemia Cells In Vivo
Authors: Farideh Miraki-Moud, Linda Ariza-McNaughton, Essam A Ghazaly, Katharine A Hodby, Phuong Luong, Andrew Clear, Fareeda Sohrabi, John Bomalaski, John Gribben, Dominique Bonnet, Peter Szlosarek, David C Taussig
Journal: Blood (2013)
Induction of androgen receptor by a novel nitroacridine, C-1748: Implications for its role as a chemotherapeutic agent in hormone independent prostate cancer
Authors: Kiranmayi Tadi, Yuangen Chen, Badithe T. Ashok, Debabrata Banerjee, Jerzy Konopa, Raj K. Tiwari
Journal: Cancer Research (2005)

5885   Development of a chemotherapeutic regimen against prostate cancer (CaP) is a challenge. We have identified a novel nitroacridine, C-1748 (Capridine-β) that has pronounced antitumor activity in human prostate cancer xenograft models and its activity was comparable in both hormone dependent (LnCaP) and hormone independent (DU-145) models. In an effort to delineate the molecular targets of C-1748, we found a marked induction of androgen receptor (AR) in C-1748 treated hormone independent DU-145 cells. The induction of the androgen receptor was observed starting at 6 hours after treatment with 5 nM C-1748 and continued to increase till 24 hours as measured by western blot analysis. These observations were further confirmed by immunoflourescence studies which showed a dose dependent enhancement of AR in response to C-1748 in DU-145 cells. We also examined the steady state level of ERβ which showed a dose dependent down regulation consistent with the anticancer effect of ERβ in prostate cancer. The functional consequence of C-1748 mediated AR induction in hormone independent CaP was analyzed by examining the synergistic effect of the anti-androgen flutamide and C-1748 on DU-145 and LnCaP cells by XTT assays. We observed marked synergistic activity between C-1748 and flutamide in DU-145 cells suggesting that the andogen receptor induced by C-1748 was functional. In LnCaP, flutamide inhibited cell proliferation but no synergism with C-1748 was observed. We conclude that androgen receptor mediated signal transduction is one of the targets of C-1748 that is presumably restricted to hormone independent cells. This implies that C-1748 can be incorporated synergistically in an antiandrogen based treatment regimen for hormone independent, highly aggressive prostate cancer.
Authors’ reply to Caldwell
Authors: Zac Etheridge, Emma Gatland
Journal: BMJ (2015)

In the Tracey case, no distinction is made regarding the mode of dying. Mrs Tracey had advanced lung cancer, a cervical spine injury, and pneumonia.1 2 Testimony given by David Pilcher, chairman of Research Councils UK, states that the chance of successful resuscitation in such a case is extremely low. As far as has been reported, Mrs Tracey had no cardiac problems; she was therefore likely to die of what Caldwell describes as …
Abstract 17782: New Generation Drug Eluting Stent Has Increased Vascular Healing by Resolved Postprocedural Incomplete Stent Apposition
Authors: Sang-Rok Lee, Hye-Eun Yoon, Min-Ju Song, Sun-Hwa Lee, Kyoung-Suk Rhee, Jae-Keon Chae, Won-Ho Kim, Jae-Ki Ko
Journal: Circulation (2011)

Background: While there are controversies regarding the late clinical impact of post-procedural incomplete stent apposition (PISA) and late incomplete stent apposition (LISA), there has been limited data in the newer generation of drug eluting stent. The aim of this study was to investigate the morphologic change of PISA and incidence of LISA during 1 year follow up. Methods: We prospectively enrolled 128 patients who underwent percutaneous coronary intervention (PCI); stable angina (n=30), unstable angina (n=82), and non-ST segment elevation myocardial infarction (n=16) (61.2±10.4 years, 78 male, 194 lesions - 106 left anterior descending artery, 25 left circumflex artery, 63 right coronary artery). The implanted stent was randomly assigned (the proportion of 2:1), zotarolimus eluting stent (group I, n=130, Endeavor Resolute TM , Medtronic) or everolimus eluting stent (group II, n=64, Xience TM V, Abbott Vascular). Post-PCI and 1 year follow up intravascular ultrasound (IVUS) analysis were performed in all patients. Results: There were no baseline clinical, angiographic, and procedural differences between the two groups. The Post-PCI external elastic membrane (EEM) volume (group I vs group II, 377.2±111.8 vs 436.1±219.6 mm 3 , p =0.155), Post-PCI lumen volume (208.3±66.1 vs 233.8±112.3 mm 3 , p =0.283), 1 year EEM volume (387.4±106.8 vs 436.6±218.3 mm 3 , p =0.240), 1 year lumen volume (212.5±64.9 vs 231.9±112.5 mm 3 , p =0.395), and 1 year intra-stent neointimal hyperplasia volume (4.8±7.3 vs 5.2±17.6 mm 3 , p =0.914) by IVUS analysis were not different between the two groups. There were three LISA (1.5%, two Endeavor, one Xience), and ten PISA (5.2%, five Endeavor, five Xience) that were resolved (40%, three Endeavor, one Xience) or persistent (60%, two Endeavor, four Xience). However, both LISA and PISA did not associated with MACE during 1 year follow up. Conclusions: In conclusion, the incidence of both LISA and PISA was very low in new generation drug eluting stent. The morphologic healing or persistence of PISA during 1 year IVUS follow up was observed. Future larger long-term follow up study to clarify the clinical course of LISA and PISA would be needed.
Evaluation of hydrophobically-modified glycol chitosan nanoparicle as a carrier for RGD peptides
Authors: Rang-Woon Park, In-San Kim, Yoo-Shin Kim, Ick-Chan Kwon, Kwangmeyung Kim, Jong-Ho Kim, Yun-Hee Bae
Journal: Cancer Research (2006)

3084  The synthetic peptide containing Arg-Gly-Asp (RGD) motif is a ligand for integrin αvβ3 expressed on endothelial cells in the angiogenic blood vessels and has been used extensively as inhibitors of angiogenesis. As a carrier for the RGD pep tide, hydrophobically modified glycol chitosan (HGC) capable of forming nano-sized self-aggregates was prepared by the chemical conjugation of 5β-cholanic acid. The linear (lRGD) and cyclic RGD (cRGD) peptides were respectively loaded into HGC (RGD-HGC) by solvent evaporation method. Three quarters of loaded RGD peptides were released from RGD-HGC within 1 day and then gradually released for 1 week. There were no difference between the effect of free cRGD and cRGD-HGC in biological experiments in vitro such as endothelial cell adhesion and migration and proliferation. However, cRGD-HGC demonstrated much more higher effect than free lRGD, lRGD-HGC, and free cRGD on inhibiting in vivo angiogenesis in matrigel plug assay. In B16F10 melanoma-bearing mice intratumoral injection of RGD peptides and RGD-HGC nanoparticles inhibited the tumor growth and angiogenesis. cRGD-HGC group showed the smallest tumor size and the least blood vessel amount in tumor. Therefore, HGC nanoparticles have excellent potential as a carrier of RGD peptide and other peptide or protein drugs.
Call to needle times after acute myocardial infarction
Authors: J. Edhouse, J Wardrope, F P Morris, M. Hough, J. Knighton, R. Ahmad, M. Pritchard, M. Fairfield, J. Middleton, J. Rawles
Journal: BMJ (1999)

Editor—We agree with the central message of Rawles et al’s article, that for patients with acute myocardial infarction the first medical attendant has the ideal opportunity to provide early thrombolysis.1 Rawles et al show the massive reduction in call to needle times achieved when thrombolysis is given by the general practitioner who first attends the patient.
Abstract 13375: Participation in Heart Healthy Behaviors: A Secondary Analysis of the American Heart Association Go Red Heart Match Data
Authors: Cynthia Arslanian-Engoren, Jo-Ann Eastwood, Marla De Jong, Kathy Berra
Journal: Circulation (2013)

Background/Significance: The AHA created “Heart Match,” a free and secure online program that enables women to connect with each other as they fight heart disease either personally or as a caregive...
Abstract 3837: Effect of Postconditioning on Infarct Size in Patients With ST-elevation Myocardial Infarction
Authors: Peder Sorensson, Nawzad Saleh, Frederic Bouvier, Felix Bohm, Magnus Settergren, Kenneth Caidahl, Per Tornvall, Hakan Arheden, Lars Ryden, John Pernow
Journal: Circulation (2009)
Abstract 4133: Dietary Change Induced Weight Loss Produces a Dramatic Rise in Serum Homocysteine Levels: Modification by Folic Acid and B Vitamin Supplementation
Authors: Steven R Gundry, Walter J Ehrman
Journal: Circulation (2006)

It has recently been suggested that homocysteine levels rise following bariatric- surgical induced weight loss; the mechanism by which this occurs is unclear. It is also unknown whether this occurs...
Premilitary MMPI scores as predictors of combat-related PTSD symptoms
Authors: P P Schnurr, M J Friedman, S D Rosenberg
Journal: American Journal of Psychiatry (1993)

The authors used data collected before military service to assess predictors of combat-related lifetime symptoms of posttraumatic stress disorder (PTSD).The subjects were 131 male Vietnam and Vietnam-era veterans who had taken the MMPI in college and who were interviewed as adults with the Structured Clinical Interview for DSM-III-R. Scores on the basic MMPI scales were used to predict combat exposure, lifetime history of any PTSD symptoms given exposure, and lifetime PTSD classification (symptoms only, subthreshold PTSD, or full PTSD).Group means on the MMPI scales were within the normal range. No scale predicted combat exposure. Hypochondriasis, psychopathic deviate, masculinity-femininity, and paranoia scales predicted PTSD symptoms. Depression, hypomania, and social introversion predicted diagnostic classification among subjects with PTSD symptoms. The effects persisted when amount of combat exposure was controlled for.Pre-military personality can affect vulnerability to lifetime PTSD symptoms in men exposed to combat.
Management Of Pregnancy In Paroxysmal Nocturnal Hemoglobinuria (PNH): A Report Of 10 Cases From The Working Group On Pregnancy Of The Japan PNH Study Group
Authors: Kensuke Usuki, Akio Urabe, Tatsuya Kawaguchi, Naoyuki Miyasaka, Osamu Miura, Eriko Morishita, Nobuyoshi Arima, Yasuyoshi Morita, Kaichi Nishiwaki, Haruhiko Ninomiya, Akihiko Gotoh, Shinsaku Imashuku, Tsutomu Shichishima, Jun-ichi Nishimura, Yuzuru Kanakura
Journal: Blood (2013)
"Anger attacks": possible variants of panic and major depressive disorders
Authors: M Fava, K Anderson, J F Rosenbaum
Journal: American Journal of Psychiatry (1990)

The authors report a series of illustrative cases in which patients presented with sudden "spells" of anger with physical features that resembled panic attacks but lacked the affects of fear and anxiety. These spells or "attacks" of anger were experienced as uncharacteristic and were inappropriate to the situations in which they occurred. Since treatment of these attacks with antidepressants produced in each case marked improvements in behavior, the authors also formulate some hypotheses as to the nature of these episodes.
Abstract 12546: Pericardial Delayed Hyperenhancement with Magnetic Resonance Imaging Predicts Inflammation: A Histopathologic Correlation.
Authors: Andrew O Zurick, Deborah Kwon, Michael Bolen, Carmela Tan, E R Rodriguez, Zoran Popovic, Prabhakar Rajiah, Allan Klein
Journal: Circulation (2010)

Background: Some constrictive pericarditis (CP) patients studied by cardiac magnetic resonance imaging (CMR) show pericardial delayed hyperenhancement (DHE) following gadolinium contrast administration. The aim of this study was to examine the prevalence and histopathologic correlates of pericardial DHE among CP patients undergoing pericardiectomy. Methods: We identified 25 CP patients who underwent pericardiectomy following CMR- gadolinium study. Ten control subjects with no evidence of pericardial disease, who were referred for cardiac viability imaging, were also assessed. A 14-segment pericardial model was utilized to determine pericardial DHE score and thickness score. Microscopic slides were reviewed and evaluated for the presence of calcification, fibrosis, inflammation, granulation tissue, fibrin deposition, hemosiderin and mesothelial hyperplasia and all histology findings were subsequently graded on a 4-point scale. Results: DHE was present in 12 (48%) of CP patients (DHE+ group), but absent in ...
Inflammation But Not Biliary Obstruction Is Associated With Carbohydrate Antigen 19-9 Levels in Patients With Primary Sclerosing Cholangitis
Authors: Andreas Wannhoff, Christian Rupp, Kilian Friedrich, Maik Brune, Johannes Knierim, Christa Flechtenmacher, Peter Sauer, Wolfgang Stremmel, Johannes R. Hov, Peter Schirmacher, Karl Heinz Weiss, Daniel N. Gotthardt
Journal: Clinical Gastroenterology and Hepatology (2015)
435. Efficient Transduction of Tyrosine-to-Phenylalanine Mutated AAV2 Vectors Carrying Human ND4 Gene and Biodistribution Following Intravitreal Delivery in a Rodent Model — A Gene Therapy for Leber Hereditary Optic Neuropathy
Authors: Rajeshwari D. Koilkonda, William W. Hauswirth, Vince Chiodo, Sanford L. Boye, John Guy
Journal: Molecular Therapy (2012)
Abstract 2266: Development of Tricuspid Regurgitation Late After Left-Sided Valve Surgery in Patients without Significant Preoperative Tricuspid Regurgitation :A Single-Center Experience with Long-term Echocardiographic Examinations
Authors: Jae-Jin Kwak, Min-Kyung Kim, Hyung-Kwan Kim, Jin-Shik Park, Kyung-Hwan Kim, Hyun-Jae Kang, Bon-Kwon Koo, Sang-Hyun Kim, In-Ho Chae, Hyuk Ahn, Dae-Won Sohn, Byung-Hee Oh, Young-Bae Park, Yun-Shik Choi, Yong-Jin Kim
Journal: Circulation (2007)

Aim: We investigated the incidence and predictors of tricuspid regurgitation (TR) development long after left-sided valve surgery in patients without significant preoperative TR. Methods: Of 615 patients who underwent surgery for left-sided valve disease between 1992 and 1995, 335 patients without preoperative TR who completed at least 5 years of clinical and echocardiographic follow-up were enrolled. Late significant TR development was assessed by echocardiography with a mean follow-up duration of 11.6 ± 2.1 years. Results: Significant late TR was found in 90 patients (26.9%). Patients with late TR showed; an advanced age, a higher prevalence of atrial fibrillation and prior valve surgery, and a greater left atrial dimension. In addition, late TR was more frequent in patients with mitral valve surgery. Systolic pulmonary artery pressure and mean right atrial pressure were not different between the groups. Multivariate analysis showed that the preoperative atrial fibrillation (OR 5.37; 95% CI. 2.71–10.65; p&lt;0.001) was the only independent factor of late TR development. Patients that developed late TR had a lower event-free survival rate than those that did not (p=0.03). Conclusion: The development of significant TR long after left-sided valve surgery is not uncommon and is associated with a poor prognosis. The preoperative atrial fibrillation is an independent predictor of the late TR. Main Clinical and Echocardiographic Characteristics According to the Presence of Significant Late TR
Abstract 16232: Comparative Effects of Weight Loss on Ventricular Repolarization in Normotensive Morbidly Obese Patients With and Without Heart Failure
Authors: Manish Jhawar, Rita Mukerji, Martin A Alpert
Journal: Circulation (2011)

Background: Delayed ventricular repolarization has been reported in obese patients and improves with weight loss. Factors responsible for these observations have not been identified. This study com...