tbuckley/cabot-search huggingface dataset:
Abstract 848: Growth-differentiation Factor-15 Promotes Anti-inflammatory Effects And Enhances Survival After Experimental Myocardial Infarction
Authors: Tibor Kempf, Christian Widera, Udo Bavendiek, Christian Willenbockel, Mortimer Korf-Klingebiel, Anna Kanwischer, Kai C Wollert
Journal: Circulation (2007)

Growth-differentiation factor (GDF)-15 is a stress-responsive TGF-ß related cytokine. GDF-15 plasma levels are increased and provide independent prognostic information in patients with acute coronary syndrome. After coronary ligation in mice, GDF-15 protein expression is rapidly induced and remains elevated within the infarcted myocardium for at least 7 days. We therefore postulated that GDF-15 is involved in wound healing post MI. The left descending coronary artery was ligated in male GDF-15 knock-out (KO, n=36), heterozygous (+/-, n=72) and wild-type mice (WT, n=26). Six-week mortality was significantly enhanced in KO (81%) and +/- (67%), as compared to WT mice (35%, P=0.004 by log-rank test). Four days after MI, no differences in infarct size (H.E. staining), cardiac dimensions, wall thickness, and systolic function (echocardiography) were observed (n=8 –12 per group). However, cardiac rupture was more frequent in KO (31%) as compared to WT mice (4%, P&lt;0.01). Immunohistochemistry on day 4 demonstrated significantly elevated numbers of granulocytes (KO, 514±61/mm 2 vs. WT, 181±22/mm 2 ; P=0.003) and macrophages (KO, 176±19/mm 2 vs. WT, 89±11/mm 2 ; P=0.002) within the infarct border zone of KO mice (n=8–12 per group). This was paralleled by an increase in MMP-9 activity (in-gel zymography) within the infarct border zone (KO, 246±33% vs. WT, 100±14%; n=8–10; P=0.004); no differences in TIMP1 expression were noted between both genotypes. In vitro, pre-stimulation with GDF-15 dose-dependently inhibited the migration of human granulocytes towards the chemoattractant fMLP (10 −8 mol/L) in transwell migration chambers (3 μm pore size), control 100%; GDF-15 0.5ng/mL 78±5%, 5ng/mL 47±10%, 50ng/mL 34±10% (P&lt;0.001). Our data identify GDF-15 as an endogenous anti-inflammatory cytokine that inhibits leukocyte infiltration, and promotes wound healing and survival after myocardial infarction.
Is Thrombin Time Useful To Guide Peri-Procedural Management For Patients On Dabigatran Etexilate?: An In Vitro Validation Study
Authors: François Mullier, Jonathan Douxfils, Helene Baes, Justine Baudar, Sarah Lessire, Medical Doctor, Maximilien Gourdin, Jean-Francois Classen, Christian Chatelain, Bernard Chatelain, Jean-Michel Dogné
Journal: Blood (2013)
A Platform Minigene AAVS1 Targeted Safe Harbor Approach For Genetic Correction Of iPSC Derived From Patients With Each Of The 5 Genetic Forms Of Chronic Granulomatous Disease
Authors: Randall K Merling, Colin L Sweeney, Uimook Choi, Aaron Bodansky, Jessica Chu, Debra Long Priel, Douglas B Kuhns, Hongmei Wang, Sam Vasilevsky, Thomas Winkler, Suk See DeRavin, Jizhong Zou, Thomas Leto, Cynthia E. Dunbar, John Gallin, Steven M. Holland, Harry Malech
Journal: Blood (2013)
Abstract 5949: Abnormal NT-Pro-BNP Levels in Asymptomatic Long Term Survivors of Childhood Cancer Treated with Anthracyclines
Authors: Annelies M Mavinkurve-Groothuis, Jacqueline Groot-Loonen, Louise Bellersen, Milanthy S Pourier, Ton Feuth, Jos P Bokkerink, Peter M Hoogerbrugge, Livia Kapusta
Journal: Circulation (2008)

Objectives : to document plasma concentrations of cardiac Troponin T (cTnT) and NT-pro-brain natriuretic peptide (NT-pro-BNP) in a large group of asymptomatic long term survivors of childhood cancer treated with anthracyclines, to study the relation of the abnormal biomarker levels with different risk factors for anthracycline-induced cardiotoxicity and conventional echocardiographic parameters. Methods : 122 asymptomatic survivors of childhood cancer underwent a detailed echocardiography. Blood samples were taken to determine the levels of NT-pro-BNP and cTnT. Results : None of the survivors had abnormal cTnT levels. The mean NT-pro-BNP level of our survivor group was 10 pmol/l (SD±9) with a range of 1–55 pmol/l. Thirteen percent of the survivors had abnormal NT-pro-BNP levels. Abnormal NT-pro-BNP levels were significantly related to cumulative anthracycline dosage (p&lt;0.003). Eleven of 31 (35%) survivors treated with cumulative anthracycline dose of 300 mg/m 2 or more, had abnormal NT-pro-BNP levels which were significantly related to end-diastolic left ventricular internal diameter (LVIDd) indexed for body surface area (BSA) (p&lt;0.01). Conclusion : Cardiac TnT does not contribute to the early detection of late onset anthracyline-induced cardiotoxicity. Abnormal levels of NT-pro-BNP were frequently detected in asymptomatic, long term survivors of childhood cancer. Follow up of these survivors, with both echocardiography and NT-pro-BNP, is essential to answer the question whether NT-pro-BNP is an early marker for late onset anthracycline-induced cardiotoxicity.
Abstract 17800: Very Long-term Outcomes (up To 8 Years) Of Patients With Renal Insufficiency Treated With Drug-eluting Stents
Authors: Jose de Ribamar Costa, Amanda Sousa, Adriana Moreira, Ricardo Costa, Galo Maldonado, Manuel Cano, Mariana Carballo, Cantidio Campos, J Eduardo Sousa
Journal: Circulation (2010)

Background:  Despite the marked benefits of PCI with DES, especially in complex scenarios, renal insufficiency (RI) remains as an independent predictor of negative outcomes in most series of patients treated with these devices. In clinical practice, the diagnostic of RI relies, most of the time, only on the levels of serum creatinine (Cr), which may underestimate the real incidence of this disease when compared to creatinine clearance (CrCl). We sought to compare the very long term clinical outcomes of patients with RI estimated by the Cr vs. CrCl when treated with PCI with DES.   Methods:  Between May 2002 and Jan 2010, 3,320 consecutive patients treated in a single center with DES were divided into 3 groups according to their renal function:group I- normal renal function (n= 2,714); group II — Cr > 1.5mg/dL (n= 242), and; group III — Cr    Results:  Patients allocated to group III were more frequently female (58% vs. 19% in group I and 16.1% in group II, p   Conclusions:  The use of serum Cr to identify patients with RI may underestimate the occurrence of this serious illness in up to 60% of the cases. Notably, patients with “normal” Cr but impaired CrCl have poorer clinical outcomes when compared with those with normal renal function.
Abstract 851: Usual Doses of Aspirin Markedly Increase Nitric Oxide Formation in Humans
Authors: Charles H Hennekens, Wendy R Schneider, Alex Pokov, Scott Hetzel, David DeMets, Henning Schroder, Victor Serebruany
Journal: Circulation (2009)

Introduction: In ex vivo studies, aspirin added to blood, platelets, or endothelial cells releases nitric oxide (NO) presumably by synthesis of arginine and NO synthase (NOS). We know of no publish...
L'herpès et le zona: "Ectodermoses neurotropes": Étude étiologique et pathogénique.
Authors: Constantin Levaditi
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Readings in Abnormal Psychology and Mental Hygiene.
Authors: William Sentman Taylor
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anatomie topographique du système nerveux central.
Authors: Georges Guillain, Ivan Bertrand
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correlation between post therapy radiation-induced pathophysiology and T-lymphocyte sensitivity
Authors: G. D. Padula, N. Kent, J. M. Kane, B. Gates, R. Hay, N. Crompton
Journal: Journal of Clinical Oncology (2008)

22190 Background: We have developed an ex vivo technique to predict various clinical responses to radiation therapy based on radiation-induced apoptosis (RIA) in cancer patient T-lymphocytes. The method involves flow cytometric evaluation of T-lymphocytes. It is a functional assay of physiological response to radiation-induced DNA damage; almost certainly double strand breaks, as we have previously shown that ATM and NBS proteins are critical to the response. These data demonstrate the utility of the assay for clinical practice. Methods: Post-therapy radiation-induced pathophysiology (RIP) in patients was monitored and compared with pre-therapy RIA from patient T-lymphocytes. Scoring of post-therapy response was performed by trained staff at St. Mary's Health Care. Radiation-induced apoptosis in T cells was determined as previously described. Of a cohort of 73 patients, symptom data were available for 60 patients. Of the 33 symptoms scored, 23 symptoms were actually observed in the cohort of 60 patients. Symptom and apoptosis data were compared statistically by difference-of-means t-test analysis comparing apoptotic yield in symptom-free and symptom-positive patients. Variance was compared using an F-test. Results: RIA in T cells from patients with excessive therapy-induced cough, nocturia, pain, skin change, and shortness of breath, were significantly different (p<0.05). Four other symptoms were of borderline significance. Levels of RIA in T cells were consistently lower in patients exhibiting post-therapy symptoms, except in the case of skin change where higher RIA was prognostic of greater skin change (p<0.02). Conclusions: Correlation between RIA and various clinical outcomes of interest has been observed. The cohort size of the patients was modest. Taken together with our previous studies, these data suggest that RIA can be used to predict various post-therapy RIP outcomes. Therapy-induced skin change appears to indicate a positive response to radiation therapy. No significant financial relationships to disclose.
"Metopirone"
Authors: 清 三浦
Journal: BMJ (1962)

Assessment of the value of a drug in these circumstances presents formidable difficulties, and any conclusions reached on the basis of subjective criteria of this kind need to be treated with reserve.The authors came to the conclusion that haloperidol "deserves a place as an adjuvant to pethidine for routine use in labour," but whether it has any advantages over chlorpromazine in this respect seems impossible to say on the present evidence.On the dosage of 3 mg.intramuscularly no side-effects, extrapyramidal or otherwise, were seen.
Telomere Dysfunction and Cell Senescence in Chronic Lung Diseases: Therapeutic Potential
Authors: Serge Adnot, Valérie Amsellem, Laurent Boyer, Elisabeth Marcos, Mirna Saker, Amal Houssaini, Kanny Kebe, Maylis Dagouassat, Larissa Lipskaia, Jorge Boczkowski
Journal: Pharmacology & Therapeutics (2015)
Reduced intensity regimen using low dose total body irradiation prior to allogeneic transplant for hematologic malignancies: A retrospective review from the acute leukemia working party of the European Bone Marrow Transplant Group
Authors: Y. Belkacemi, N. Basara, M. Labopin, S. Hoffstetter, R. Mungai, M. Vygoda, M. Lundel, J. Finke, C. Aktinson, F. Lorchel
Journal: Journal of Clinical Oncology (2005)

6675 Background: One the main limitations myeloablative regimens is its high toxicity. This has led to the development of non-myeloablative procedures which allow for initial engraftment of stem cells and subsequent transfer of immune cells for the induction of graft-versus-tumor reaction. In this setting the impact of the low dose TBI parameters on outcome have never been studied. Methods: Data of 106 patients (pts) treated between 1998 and 2003 were analyzed. Median age was 50y (3–72), male to female ratio: 65/41. Hematologic malignancies included AML (n=26), other leukemias (n=30), myeloproliferative syndrome or myelodysplasia (n=12), lymphoma (n=23) and myeloma (n=15). Allogeneic transplant were performed from HLA identical sibling donor (n=79), MUD (n=23) or unmatched related donors (n=4). TBI delivered 2Gy in 1 fraction in 77pts whereas 29pts received a total dose 4–6Gy. The median dose rate (DR) was 0.105 (0.06–0.57) Gy/min. Results: The median follow-up was 17 (1–62) m. Engraftment was obtained in 99pts. Full chimerism was observed in 44 (61%) pts. GVHD grade I to IV was developed in 13, 19, 13, 11, respectively. it was not influenced by the TBI dose (p=0.31) or DR (p=0.27). In Univariate analyses, the 2-year LFS tends to be higher after TBI > 2Gy and using DR ≥ 0.1 Gy/min. LFS was significantly better for pts in complete remission (52% vs 34%; p=0.006), for female donor to male recipient (52% vs 36%; p=0.04), HLA id sibling donor (52% vs 12%; p<0.0001). Multivariate analysis showed 2 independent factors for relapse and LFS: HLA id sibling donor (p=0.0002; RR:12 and p<0.0001; RR: 0.18) and CR (p=0.0009; RR: 0.06 and p=0.0006; RR: 3.46). For overall survival the 3 independent factors were: CR (p=0.001, RR:3.3), HLA id sibling donor (p=0.0003; RR=0.19) and DR (p=0.02; RR:2.07). Conclusion: In this multicenter retrospective study we found that remission status and HLA sibling donor influence independently the outcome. DR seems to have an impact on OS. Incidence of GVHD, engraftment and chimerism are similar to the literature. No significant financial relationships to disclose.
腹痛-黄疸-贫血
Authors: 王玉, 韩潇, 陈嘉林, 曾学军
Journal: BMJ (2007)

@@ 患者,女,36岁,河北人,农民.因皮肤黄染10年,右季肋部疼痛1个月入院. 10年前无意中发现皮肤黄染,诊断为黄疸性肝炎,无乏力、纳差、厌油感.治疗后未复查,平素未注意面色的变化,体力劳动无受限.患者于1个月前无诱因出现右季肋部隐痛,疼痛阵发性加重,变换体位可自行缓解,无放射,与进食无关,无纳差、厌油,无恶心、呕吐,无发热、腹泻,并逐渐出现间断茶色尿,可自行消失,无便色异常,未诊治.10 d前上述症状加重,疼痛较前剧烈,持续时间较前延长,当地医生发现其皮肤黄染,考虑胆结石,梗阻性黄疸建议转上级医院就诊.
Abstract MP44: Biomarker Measures of Fish-Derived Omega-3 Fatty Acids and J-Point Elevation in the Atherosclerosis Risk in Communities (ARIC) Study
Authors: Noelle N Gronroos, Pamela J Schreiner, Elsayed Z Soliman, Lisa Harnack, Richard F MacLehose, Alvaro Alonso
Journal: Circulation (2013)

Background: Higher intake of fish-derived omega-3 polyunsaturated fatty acids (PUFAs) has been associated with lower incidence of Sudden Cardiac Death (SCD), but the exact mechanisms underlying this association are unconfirmed. Early ventricular repolarization characterized by an elevation of the QRS-ST junction (J-Point) in the surface ECG has been associated with idiopathic ventricular fibrillation, the most common cause of SCD. We aimed to study the association of fish-derived PUFAs in plasma with the prevalence of J-Point elevation. Methods: We conducted a cross-sectional analysis of participants aged 45-64 (45.7% male, 100% whites) from the Minnesota Field Center of the Atherosclerosis Risk in Communities (ARIC) Study. Participants were excluded if they did not have an ECG, had a QRS duration ≥ 120 ms, were taking Class I or Class III antiarrhythmic agents, or had prevalent cardiovascular disease. Fish-derived PUFAs were measured in plasma phospholipids as a percentage of total fatty acids, categorized into quartiles, and logistic regression was used to estimate the odds of J-Point Elevation, defined as elevation of greater than 100 microvolts in at least two contiguous leads. Models were adjusted for potential confounders and tests of linear trend were conducted by assigning the median values for each exposure category and modeling as a continuous variable. Results: Among 3,330 eligible individuals, 126 presented J-Point elevation. Median fish-derived fatty acid percentage was 3.2% (range: 0.7-12.2). Using multivariable analyses, plasma measures of fish-derived omega-3 PUFAs were linearly associated with the log odds of J-Point elevation with increasing fatty acid percentages associated with lower odds of J-Point elevation (see Table). Conclusions: In this population, higher plasma levels of fish-derived PUFAs were inversely associated with J-Point elevation. Fish-derived PUFAs could reduce risk of SCD through decreased prevalence of early repolarization.
Medical Aspects of Peptic Ulcer
Authors: Albert F. R. Andresen
Journal: Annals of Internal Medicine (1931)

Article1 August 1931Medical Aspects of Peptic UlcerALBERT F. R. ANDRESEN, M.D., F.A.C.P.ALBERT F. R. ANDRESEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-2-192 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is almost necessary to make an excuse for writing about peptic ulcer. Medical literature of the past twenty years has been filled with articles on this subject, volumes have been written about it and a verbal war between the advocates of medical and surgical treatment is still being waged with great intensity. When so much verbiage is wasted on any subject it engenders the suspicion that the reason for this wastage is a lack of knowledge or understanding of the subject. In the case of ulcer this is undoubtedly true. So much good research work has been done in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Submitted for publication, February 19, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1931Volume 5, Issue 2Page: 192-200KeywordsPeptic ulcersUlcers Issue Published: 1 August 1931 PDF downloadLoading ...
Acceptability of side effects as reason for stopping may bias results
Authors: P. Ramchandani, V. Webb
Journal: BMJ (1995)

patients with cancers before the skin cancer were retained in the analysis or not (Frisch et al, unpublished data).This argues against Sasieni and Bataille's proposal.By no means do we consider our observations to be evidence of a causal role for ultraviolet light in the pathogenesis of non-Hodgkin's lymphoma.Sasieni and Bataille and Robert Newton suggest that immunosuppression rather, than ultraviolet light explains our findings.We do not disagree with this.As we suggested in our paper, one of the possible mechanisms that link skin cancers and non-Hodgkin's lymphoma is the local and systemic immunological dysregulation caused by ultraviolet light.34The considerable indirect support for such an association5 needs further consideration.
Eye-Strain in Every-Day Practice.
Authors: Sydney Stephenson
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal