tbuckley/cabot-search huggingface dataset:
High rates of metallo-beta-lactamase-producing Klebsiella pneumoniae in Greece - a review of the current evidence
Authors: A Vatopoulos
Journal: Eurosurveillance (2008)

For the last four years Greece has faced a large number of infections, mainly in the intensive care units (ICU), due to carbapenem-resistant, VIM-1-producing Klebsiella pneumoniae. The proportion of imipenem-resistant K. pneumoniae has increased from less than 1% in 2001, to 20% in isolates from hospital wards and to 50% in isolates from ICUs in 2006. Likewise, in 2002, these strains were identified in only three hospitals, whereas now they are isolated in at least 25 of the 40 hospitals participating in the Greek Surveillance System. This situation seems to be due to the spread of the blaVIM-1 cassette among the rapidly evolving multiresistant plasmids and multiresistant or even panresistant strains of mainly K. pneumoniae and also other enterobacterial species. However, the exact biological basis of this phenomenon and the risk factors that facilitate it are not yet fully understood. Moreover, the fact that most strains display minimum inhibitory concentration (MIC) values below or near the Clinical Laboratory Standard Institute (CLSI) resistance breakpoint create diagnostic and therapeutic problems, and possibly obstruct the assessment of the real incidence of these strains. An evidence-based consensus on the therapeutic strategy for these infections is urgently needed. The problem of VIM-producing K. pneumoniae was timely recognized by the Greek System for the Surveillance of Antimicrobial Resistance and various guidelines, including advice on antibiotic policy and infection control, were developed by the National Centre for Disease Control and Prevention. However, these measures have yet had a relatively small impact on the situation. The best way to handle the problem of antibiotic resistance would be the development and implementation of a national integrated strategic action plan (currently under development) affirming the political commitment of the public health administration in confronting this issue.
An outbreak of Campylobacter jejuni enteritis in a school of Madrid, Spain
Authors: M Jiménez, P Soler, J D Venanzi, P Canté, C Varela, J. F. Martinez Navarro
Journal: Eurosurveillance (2005)

An outbreak of gastroenteritis caused by Campylobacter infection was identified in May 2003 in a school in Madrid, Spain. Eighty one cases were identified in a total of 253 people studied. A retrospective cohort study showed that a custard made with ultra high temperature (UHT) milk was associated with illness (RR: 3.15; 95% CI: 1.25-7.93). The custard was probably contaminated with Campylobacter jejuni from a raw chicken prepared a day previously in the same kitchen. Our recommendations were to periodically remind the school s authorities how to act if an outbreak should be suspected, to include the monitoring of a food handler s working day in each environmental investigation in order to detect any risk behaviour; to implement microbiological analysis from the surfaces and utensils of the collective kitchens and improve the sanitary education of food handlers.
MAPK-Erk1/2 Pathway Activation and Survival Of Chronic Lymphocytic Leukemia (CLL) Cells Is Induced By In Vitro Modeling Of The Tumor Microenvironment and Can Be Effectively Inhibited Using The MEK1 Inhibitor MEK162
Authors: Kyle Crassini, William s Stevenson, Stephen P Mulligan, Frcpa
Journal: Blood (2013)
Abstract 3405: Thoracic Aortic Calcium vs. Coronary Artery Calcium for the Prediction of Coronary Heart Disease and Cardiovascular Events
Authors: Nathan D Wong, Heidi Gransar, Leslee J Shaw, Donna Polk, Johanna Moon, Romalisa Miranda-Peats, Sean Hayes, John D Friedman, Louise Thomson, Alan Rozanski, Daniel S Berman
Journal: Circulation (2007)

Background: Coronary artery calcium (CAC) measured by computed tomography (CT) independently predicts coronary heart disease (CHD) and cardiovascular disease (CVD) events. We investigated whether t...
P0333 : An epidemiological association between the trends of nucleoside analogue prescription and liver cancer incidence from 1999 to 2012 in Hong Kong, China
Authors: W.-K. Seto, E.H.Y. Lau, J.T. Wu, I.F.-N. Hung, W.K. Leung, J. Fung, C.-L. Lai, M.-F. Yuen
Journal: Journal of Hepatology (2015)
FDA: Epilepsy Drugs May Carry Skin Risks for Asians
Authors: Bridget M Kuehn
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Empathy and outcome in brief focal dynamic therapy
Authors: N K Free, B L Green, M C Grace, L A Chernus, R M Whitman
Journal: American Journal of Psychiatry (1985)

In an attempt to test the hypothesis that therapist empathy is an important variable in successful dynamic therapy, the authors collected outcome measures and empathy ratings in the brief focal dynamic therapy of 59 patients. There was no significant agreement among patients, therapists, and clinical supervisors when they used the same scale to rate therapist empathy for the same sessions. Only the patients' ratings correlated significantly with some of the outcome measures, and they added modest but statistically significant predictive variance on multiple regression analysis. The authors discuss the implications of these findings for the traditional mode of supervision of dynamic therapy.
Residual immunity in older people against the influenza A(H1N1) – recent experience in northern Spain
Authors: E Pérez-Trallero, L Piñeiro, D Vicente, M Montes, G Cilla
Journal: Eurosurveillance (2009)

The 2009 pandemic influenza A(H1N1) virus has a higher incidence in children and young adults, a pattern that has also been reported in seasonal influenza caused by the influenza A(H1N1) virus. We analysed age at infection in symptomatic patients with influenza in the Basque Country (northern Spain), reported through the sentinel influenza surveillance system which monitors 2.2-2.5% of the population. Between September 1999 and August 2009, influenza A(H3N2) or seasonal influenza A(H1N1) was detected in 941 patients, and from April to August 2009, pandemic influenza A(H1N1) was detected in 112 patients. The H3/H1 seasonal influenza ratio was between 3.3 and 3.4 in the under 60 year-olds, but 9.8 in older individuals, suggesting that people born before 1950 have residual immunity against the influenza A H1N1 subtype (both seasonal and pandemic). Introduction In 1957, the Asian influenza pandemic was caused by influenza A(H2N2) virus, which circulated until 1968 when it was displaced by the influenza A(H3N2) virus which was responsible for the Hong Kong pandemic. Before 1957, direct descendants of the influenza A(H1N1) virus that had caused the 1918 pandemic (Spanish flu) had circulated. In 1977, an influenza A(H1N1) strain re-emerged, which, together with the dominant influenza A(H3N2) strain, has been the cause of seasonal human influenza for more than three decades [1]. Despite the prolonged co-circulation of both subtypes, few studies have analysed their ability to affect distinct age groups. The current pandemic influenza A(H1N1) virus, influenza A(H1N1)v, which emerged in the spring of 2009, has spread throughout the world. The aim of this study was to compare the distribution in distinct age groups of infections caused by the two subtypes of seasonal influenza in the past 10 seasons and refer therelate this to recent infections due to influenza A(H1N1)v.
Management of women with early breast cancer
Authors: J. Bell, D. Robinson, H. Moller, R. Williams, H. Fielder, R T D Oliver, U. M Macleod, S. Ross, G. C M Watt, C. Twelves, W D George, C. Gillis
Journal: BMJ (2000)

Risks of syringe exchange programmes in prisons prevailEditor-Since 1998, 203 366 prisoners in Bavaria have been tested for HIV when placed under detention; 1379 prisoners were diagnosed for the first time as being infected with HIV.During the course of their detention around 35 000 inmates have been tested, predominantly drug addicts; only one serum conversion has been found.
Ruxolitinib-Induced Modulation of Bone Marrow Microenvironment in Patients with Myelofibrosis Is Associated with Inflammatory Cytokine Levels
Authors: Hans Michael Kvasnicka, Juergen Thiele, Carlos E. Bueso-Ramos, William Sun, Jorge E. Cortes, Hagop M. Kantarjian, Srdan Verstovsek
Journal: Blood (2014)
Abstract 2008: Impact of Hyperglycemia on Myocardial Damage and its Prognostic Implications in Patients with Acute ST-Segment Elevation Myocardial Infarction (STEMI) Assessed by Contrast-Enhanced Cardiac Magnetic Resonance Imaging (CMR)
Authors: Christoph J Jensen, Markus Jochims, Kai Nassenstein, Michael Bell, Thomas Schlosser, Georg V Sabin, Oliver Bruder
Journal: Circulation (2008)

To investigate the impact of admission glucose levels on myocardial damage and long term outcome in patients with acute STEMI using contrast-enhanced CMR. 130 consecutive patients (104 males; mean age 59.4±11.8 years) with first reperfused STEMI were included. Hyperglycemia was defined as glucose levels above 7.8mmol/l. CMR was performed within 3.9±2.2 days after admission on a 1.5 Tesla MR System. The imaging protocol included SSFP cine sequences for the calculation of LV function, volumes and mass. Total no reflow volumes (NRV) and delayed enhancement volumes (DEV) were calculated from planimetry of the IR-SSFP stacks of short axis images by disc-summation performed early / late following administration of 0.2mmol/kg/BW of gadodiamid. NRV and DEV were expressed as percent of LV Mass (NR%, DE%). Continuous variables were compared by Mann-Whitney test. Correlation of admission hyperglycemia and NR% was tested by spearman rank test. Patients were prospectively followed for 30±9 months. A stepwise logistic regression model was used to analyze the impact of hyperglycemia and CMR parameters on NR% and outcome. 55 of 130 (42%) patients had hyperglycemia on admission. Patients with admission hyperglycemia had lower LV ejection fraction (38.6±12.9% vs. 47.7±11.9%, p=0.001), greater ESV (89.2±39.2ml vs. 71.7±34.1ml, p=0.002), greater LV Mass (156.7±40.4g vs. 136.3±36.7g, p=0.003), larger DE% (19.3±13.8% vs. 9.7±8.5%, p&lt;0.001) and larger NR% (8.1± 9.2% vs. 2.3± 4.2%, p&lt;0.001). Admission hyperglycemia correlated moderate but significant to DE% (r=0.386, p&lt;0.001) and NR% (r=0.421, p&lt;0.001). In a multivariable logistic regression model admission hyperglycemia was an independent predictor (OR 6.8; CI 2.8 −16.6) of extensive (&gt; median) microvascular obstruction, extensive delayed enhancement (OR 3.2; CI 1.5–7.1) and was associated with an increased risk for death and reinfarction (OR 4.7; CI 1.2–18.3) during follow up. Admission hyperglycemia in acute, reperfused STEMI is independently related to the extent of microvascular obstruction on early contrast-enhanced CMR and is associated with worse long-term outcome. Thus, CMR may play a major role in monitoring effects of glucose control on myocardial damage in AMI.
Effect of the I1307K polymorphism in <i>APC</i> confers a higher risk for polyp recurrence in Jewish Ashkenazi carriers
Authors: A. Figer, E. Shacham-Shmueli, E. Liberman, E. Sagiv, M. J. Hall, O. Dolkart, D. Kazanov, S. Kraus, A. I. Neugut, M. Inbar, N. Arber
Journal: Journal of Clinical Oncology (2009)

e22003 Background: The I1307K adenomatous polyposis coli gene variant, prevalent among Ashkenazi Jews, may increase risk for colorectal neoplasia [colorectal cancer (CRC) and CR adenoma]. We studied the clinical importance of this polymorphism in 3283 Israelis undergoing colonoscopic assessment. Methods: Blood samples and risk factor information were collected from individuals undergoing colonoscopic examination at our medical center. Germline genetic analysis for the APC I1307K variant was performed using real-time PCR for DNA extracted from peripheral mononuclear cells. Results: The overall prevalence of the I1307K polymorphism was 8.1% (10.2% among Ashkenazi while only 2.5% among Sephardic Jews, p=0.001). The overall adjusted odds ratio (OR) for CR neoplasia among carriers was 1.3 (1.0 -1.7, p=0.049). Among Ashkenazi Jews, the I1307K variant was significantly more prevalent among persons with a personal or family history (1 st degree) of CR neoplasia (p=0.01) as compared to Ashkenazi Jews with no family history. The histopathological features of adenomas and cancers did not differ between carriers and non-carriers. No interactions were found between the I1307K variant and demographic, lifestyle, or dietary modifiers that independently modulated the risk for CR neoplasia. Conclusions: In the general population, the APC I1307K variant does not change the risk or prognosis of colorectal neoplasia in carriers and does not necessarily change their clinical practice. Nevertheless, the variant, which is more prevalent among high risk individuals of Ashkenazi Jewish origin, is an important risk factor for the assessment of recurrence of neoplasia as it confers a higher risk for polyp recurrence in this population. No significant financial relationships to disclose.
GONOCOCCUS BACTEREMIA WITH JOINT AND SKIN MANIFESTATIONS; A CASE REPORT
Authors: Ruth C. Foster
Journal: Annals of Internal Medicine (1942)

Case Reports1 May 1942GONOCOCCUS BACTEREMIA WITH JOINT AND SKIN MANIFESTATIONS; A CASE REPORTRUTH C. FOSTER, M.D.RUTH C. FOSTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-5-1018 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe following case is reported because it represents a syndrome characterized by fever, joint pains and rash typical of certain gonococcal bacteremias. It was undiagnosed before the laboratory isolated the organism from the blood stream, but it is probable that the case could have been diagnosed from the clinical course alone and proper therapy started at once. Several similar cases have been reported by Wheeler and Cornell,8 Rubenstone,7 Cabot,1 Filler,3 and Keil.5 The following case report is identical in many ways to these reported cases.CASE REPORTA 20-year-old white female was admitted to the University of Wisconsin Student Infirmary...Bibliography1. CABOT RC: An obscure general infection, Boston Med. and Surg. Jr., 1927, cxcvii, 1141. Google Scholar2. DAVIS JS: Diagnosis and treatment of gonorrheal septicemia and gonorrheal endocarditis, Arch. Int. Med., 1940, lxvi, 418. CrossrefGoogle Scholar3. FILLER W: Gonococcemia with recovery, Jr. Am. Med. Assoc., 1933, c, 1149. CrossrefGoogle Scholar4. FUTCHER PH: The double quotidian temperature curve of gonococcal endocarditis. A diagnostic test, Am. Jr. Med. Sci., 1940, cxcix, 23. CrossrefGoogle Scholar5. KEIL H: A type of gonococcal bacteraemia with characteristic haemorrhagic vesiculopustular and bullous skin lesions, Quart. Jr. Med., 1938, vii, 1. Google Scholar6. OSLERMCCRAE WT: Modern medicine, 1913, i, 743. Google Scholar7. RUBENSTONEISRAEL AIS: Gonococcemia with recovery, Jr. Am. Med. Assoc., 1932, xcix, 1685. Google Scholar8. WHEELERCORNELL GWNW: Gonococcal bacteremia in a woman with apparent cure by surgical intervention, Jr. Am. Med. Assoc., 1930, xciv, 1568. CrossrefGoogle Scholar9. WILLIAMS RH: Gonococcic endocarditis. A study of twelve cases with ten postmortem examinations, Arch. Int. Med., 1938, lxi, 26. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Madison, Wisconsin*Received for publication July 21, 1941. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical studies on gonococcal arthritis and reiter's syndrome and measurement of gonococcal and bedsonia antibodies 1 May 1942Volume 16, Issue 5Page: 1018-1022KeywordsArthralgiaBacteremiaBloodFeversNeisseria gonorrhoeaeRashesResearch laboratoriesRivers Issue Published: 1 May 1942 PDF downloadLoading ...
P0311 : Balb/c and C57/Bl6 mice exhibit differences in their susceptibility and anti-tumor response to B16F10 melanoma liver metastasis
Authors: F. Foerster, S. Strobl, L. Kaps, S.-Y. Weng, Y.O. Kim, M. Bros, M. Diken, S. Boegel, J. Castle, E. Bockamp, D. Schuppan
Journal: Journal of Hepatology (2015)
Abstract 671: High Density Lipoprotein Restores Impaired Re-Endothelialization Capacity of Endothelial Progenitor Cells from Patients with Metabolic Syndrome via Lysophospholipid Receptor S1P3-mediated NAD(P)H Oxidase Inhibition
Authors: Sajoscha A Sorrentino, Christian Besler, Ferdinand H Bahlmann, Martin Meyer, Maja Mueller, Mariko Heinemann, Michael Sieniawski, Stella Flemmer, Matthias J Bahr, Hermann Haller, Helmut Drexler, Ulf Landmesser
Journal: Circulation (2006)

Introduction: Recent studies suggest that endothelial injury in the absence of sufficient endothelial progenitor cells (EPCs) promotes progression of vascular disease. High density lipoprotein (HDL...
Abstract 15886: Tako-Tsubo Cardiomyopathy is Not a Benign Disease: Results of the German Tako-Tsubo Registry
Authors: Birke Schneider, Anastasios Athanasiadis, Wolfgang Pistner, Johannes Schwab, Uta Gottwald, Ralph Schoeller, Wolfgang Toepel, Klaus-Dieter Winter, Christoph Stellbrink, Tobias Muller-Honold, Christian Wegner, Claudia Stollberger, Udo Sechtem
Journal: Circulation (2011)

Aims: Tako-Tsubo cardiomyopathy (TTC) is regarded a benign disease since left ventricular (LV) function returns to normal within a short period of time. However, severe complications have been repo...
Cell-free DNA levels in colorectal cancer patients treated with irinotecan, healthy controls, and non-cancer patients with comorbidity.
Authors: Karen-Lise Garm Spindler, Ane L Appelt, Niels Pallisgaard, Rikke Fredslund Andersen, Ivan Brandslund, Anders Kristian Moeller Jakobsen
Journal: Journal of Clinical Oncology (2014)

3559 Background: The present study investigated the clinical value of total cell free DNA (cfDNA) measurement in metastatic colorectal cancer patients treated with second-line irinotecan monotherapy. Methods: Patient treated with second-line irinotecan for metastatic colorectal cancer (n=100), a cohort of healthy controls with and without co-morbidity (n=70 and 100, respectively) were included. CfDNA was quantified by an in-house developed qPCR (Spindler et al 2012) from plasma samples drawn prior to the first cycle of chemotherapy and at time of progression. Results: CfDNA levels were significantly higher in cancer patients compared to controls, with a clear capability for discriminating between the groups (AUC 0.82, p<0.0001). Patients with high levels had a shorter outcome compared to those with lover levels. The cohort independent upper normal limit (UNL) divided patients into high and low risk groups. The PFS was 2.1 months (95% CI 2.0-3.4), and 6.5 (95% CI 4.2-7.2) months, (HR 2.53 (95% CI 1.57-4.06), p=<0.0001) and OS 7.4 months (95% CI 4.3-8.7) and 13.8 months (95% CI 11.9-18.9), (HR 2.52 (95% CI 1.54-4.13), p<0.0001), respectively. Cox regression multivariate analysis showed a PFS Hazard Ratio of 1.4 (95% CI 1.1-1.7) for each increase in cfDNA quartile, p=0.03, and 1.6 (1.3-2.0) for OS, p<0.0001, respectively. CfDNA levels measured at time of progression showed similar consistent prognostic value. Conclusions: CfDNA measurement contains important clinical information and could become a useful tool for prediction of outcome from chemotherapy in mCRC.
Healthcare-associated infections in European long-term care facilities: how big is the challenge?
Authors: C Suetens
Journal: Eurosurveillance (2012)

Preview this article: Healthcare-associated infections in European long-term care facilities: how big is the challenge?, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/17/35/art20259-en-1.gif
Clinical medical officers could provide service
Authors: S. S. Sharma
Journal: BMJ (1994)

EDITOR,—Jackie Morris proposes that the gap between community and hospital services for elderly people should be bridged by a new subspecialty of community geriatric medicine.1 Since the formation of trusts and the implementation of community care, consultants in medicine of old age have been more involved in hospital work. The role of community geriatrician as specified by Morris seems the same as the role of a consultant geriatrician used to be when the specialty of geriatric medicine …
Hyperglycemia in Acute Illness
Authors: Ketan Dhatariya
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nursing shortages
Authors: A. Maynard
Journal: BMJ (1996)

Alternatives to hospital careStudy's results may not apply elsewhere EDrroR,-I wish to urge caution in extrapolating the results ofJoanna Coast and colleagues' study, which implies that a tenth of patients admitted to general hospitals could be relocated to more appropriate care.'I am leading a "total fundholding" project in Winchester, in which the practice will purchase all care on behalf of our patients, and have been examining the practice's use of acute services.We obviously have an inter- est in using expensive acute services carefully, and to that end we have followed up all our acute