tbuckley/cabot-search huggingface dataset:
Flexible Electrohydrodynamic Fluid-Driven Valveless Water Pump via Immiscible Interface
Authors: Zebing Mao, Naoki Hosoya, Shingo Maeda
Journal: Cyborg and Bionic Systems (2024)

The conventional electrohydrodynamic (EHD) pump is limited to pumping functional and dielectric liquids, which restricts its applications in fields like microfluidics, food safety, and materials production. In this study, we present a flexible water pump driven by EHD fluid, achieved by integrating valveless elements into the fluidic channel. Our approach leverages the water–EHD interface to propel the immiscible aqueous liquid and reciprocate this process using the nozzle–diffuser system. All components of the water pump are digitally fabricated and assembled. The valveless parts are created using a laser cutting machine. Additionally, we develop a model for the EHD pump and nozzle–diffuser system to predict the generated flow rate, considering factors such as the asymmetrical performance of the EHD pump, pulse frequency, applied voltage, and structural parameters. Finally, we experimentally characterize the flow rates of both the EHD pump and water pump and apply the newly developed device to air bubble manipulation and droplet generation. This research broadens the range of specialized liquids pumped by EHD pumps to include other aqueous liquids or mixtures.
A commentary on ‘Preventing postoperative cognitive dysfunction using anesthetic drugs in elderly patients undergoing noncardiac surgery: a systematic review and meta-analysis’
Authors: Jing Huang, Xin Zhu, Weijie Cao, Xinru Guo, Xue Liu
Journal: International Journal of Surgery (2024)

Department of Anesthesiology,The first affiliated hospital of dalian medical university, 116011,Dalian,China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Anesthesiology,The first affiliated hospital of dalian medical university, 116011,Dalian,China. E-mail address: [email protected] (X. L). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A commentary on ‘A systematic review and meta-analysis comparing negative pressure wound therapy to conventional wound dressings in the treatment of open fractures’
Authors: Muthupandian Saravanan, Samhita Ganugula, Jesu Arockiaraj, Tsehaye A. Dejene
Journal: International Journal of Surgery (2024)

Saravanan, Muthupandian; Ganugula, Samhita; Arockiaraj, Jesu; Dejene, Tsehaye A. PhD Author Information
Silibinin, a potential fasting mimetic, inhibits hepatocellular carcinoma by triggering extrinsic apoptosis
Authors: Biying Xiao, Yanyu Jiang, Shuying Yuan, Lili Cai, Tong Xu, Lijun Jia
Journal: MedComm (2024)

Abstract Fasting, without inducing malnutrition, has been shown to have various beneficial effects, including the inhibition of tumor initiation and progression. However, prolonged fasting poses challenges for many cancer patients, particularly those in intermediate and terminal stages. Thus, there is an urgent need for the development of fasting mimetics which harness the protective effects of fasting but more suitable for patients. In this study, we first highlighted the pivotal role of silibinin in AMP‐activated protein kinase (AMPK) pathway and may serve, as a potential fasting mimetic via screening hepatoprotective drugs. Further metabolic analysis showed that silibinin inhibited the adenosine triphosphate (ATP) levels, glucose uptake and diminished glycolysis process, which further confirmed that silibinin served as a fasting mimetic. In addition, fasting synergized with silibinin, or used independently, to suppress the growth of hepatocellular carcinoma (HCC) in vivo. Mechanistically, silibinin upregulated death receptor 5 (DR5) through AMPK activation, and thus promoting extrinsic apoptosis and inhibiting HCC growth both in vitro and in vivo. Inhibition of AMPK using small interfering RNA (siRNA) or compound C, an AMPK inhibitor, significantly attenuated the upregulation of DR5 and the apoptotic response induced by silibinin. These findings suggest that silibinin holds promise as a fasting mimetic and may serve as an adjuvant drug for HCC treatment.
Highlighted research articles
Journal: Cancer Discovery (2024)

In This Issue| January 12 2024 Highlighted research articles Author & Article Information Online ISSN: 2159-8290 Print ISSN: 2159-8274 ©2024 American Association for Cancer Research2024American Association for Cancer Research Cancer Discov (2024) 14 (1): 5–7. https://doi.org/10.1158/2159-8290.CD-14-1-ITI Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record January 12 2024 Citation Highlighted research articles. Cancer Discov 1 January 2024; 14 (1): 5–7. https://doi.org/10.1158/2159-8290.CD-14-1-ITI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search The proportion of patients with cancer that benefit from precision oncology remains under debate. Suehnholz and colleagues sought to quantify the expansion of clinical actionability over a 5-year period from 2017 to 2022 by annotating 47,271 clinically sequenced solid tumors for actionable molecular alterations using the OncoKB knowledge base and showed that the fraction of tumors harboring a standard care response biomarker increased (8.9% to 31.6%) while tumors carrying non-actionable drivers were reduced (44.2% to 22.8%). Additionally, frequent alterations in TP53, KRAS, and CDKN2A were observed in tumors with limited or no clinical actionability. These results indicate that progress has been made with precision oncology-based treatment paradigms, but strategies to target currently undruggable oncogenic drivers remain an unmet need. See article, p. 49. Despite the efficacy of Bruton's tyrosine kinase (BTK) inhibitors in B-cell malignancies, relapse occurs over time and therapeutic options for patients with relapsed/refractory disease... You do not currently have access to this content.
The effect of perioperative sequential application of multiple doses of tranexamic acid on postoperative blood loss after PLIF: a prospective randomized controlled trial
Authors: Wei Dong, Yuchen Tang, Miao Lei, Zhaoxin Ma, Xiaojun Zhang, Jieliang Shen, Jie Hao, Wei Jiang, Zhenming Hu
Journal: International Journal of Surgery (2024)

Tranexamic acid (TXA) has been utilized in spinal surgery to effectively reduce intraoperative blood loss (IBL) and allogeneic blood transfusion rates. However, the traditional TXA regimen might last the entire duration of hyperfibrinolysis caused by surgical trauma, resulting in its limited ability to reduce postoperative blood loss (PBL). Therefore, the aim of this study was to investigate the effectiveness of perioperative sequential administration of multiple doses of TXA in reducing PBL in patients who underwent posterior lumbar interbody fusion (PLIF).
Underwater robots and key technologies for operation control
Authors: Linxiang Sun, Yu Wang, Xiaolong Hui, Xibo Ma, Xuejian Bai, Min Tan
Journal: Cyborg and Bionic Systems (2024)

Over time, the utilization of the Underwater Vehicle-Manipulator System (UVMS) has steadily increased in exploring and harnessing marine resources. However, the underwater environment poses big challenges for controlling, navigating, and communicating with UVMS. These challenges have not only spurred the continuous advancement of related technologies, but also made the development of the UVMS even more captivating. This article firstly provides a review of development status of the UVMS and discusses the current limitations and future directions, and then reviews in detail the dynamic and hydrodynamic modeling methods, and analyzes the principles, advantages, and disadvantages of various approaches. Then, we try to review 2 key technologies of operation control methods, including underwater positioning and navigation technologies and vehicle-manipulator coordinated control approaches. Finally, a reasonable prospect for the future development of UVMS is given.
ASMNet: Action and Style-Conditioned Motion Generative Network for 3D Human Motion Generation
Authors: Zongying Li, Yong Wang, Xin Du, Can Wang, Reinhard Koch, Mengyuan Liu
Journal: Cyborg and Bionic Systems (2024)

Extensive research has explored human motion generation, but the generated sequences are influenced by different motion styles. For instance, the act of walking with joy and sorrow evokes distinct effects on a character’s motion. Due to the difficulties in motion capture with styles, the available data for style research are also limited. To address the problems, we propose ASMNet, an action and style-conditioned motion generative network. This network ensures that the generated human motion sequences not only comply with the provided action label but also exhibit distinctive stylistic features. To extract motion features from human motion sequences, we design a spatial temporal extractor. Moreover, we use the adaptive instance normalization layer to inject style into the target motion. Our results are comparable to state-of-the-art approaches and display a substantial advantage in both quantitative and qualitative evaluations. The code is available at https://github.com/ZongYingLi/ASMNet.git .
Follow-up from the A041202 study shows continued efficacy of ibrutinib regimens for older adults with CLL
Authors: Jennifer A. Woyach, Gabriela Perez Burbano, Amy S. Ruppert, Cecelia Miller, Nyla A. Heerema, Weiqiang Zhao, Anna Wall, Wei Ding, Nancy L. Bartlett, Danielle M. Brander, Paul M. Barr, Kerry A. Rogers, Sameer A. Parikh, Deborah M. Stephens, Jennifer R. Brown, Gerard Lozanski, James Blachly, Sreenivasa Nattam, Richard A. Larson, Harry Erba, Mark Litzow, Selina Luger, Carolyn Owen, Charles Kuzma, Jeremy S. Abramson, Richard F. Little, Shira Dinner, Richard M. Stone, Geoffrey Uy, Wendy Stock, Sumithra J. Mandrekar, John C. Byrd
Journal: Blood (2024)
Arcturus (XBB.1.16) COVID-19 variant and global public health emergency: correspondence
Authors: Hinpetch Daungsupawong, Viroj Wiwanitkit
Journal: International Journal of Surgery (2024)

aPrivate Academic Consultant, Phonhong, Lao People's Democratic Republic bAdjunct professor, Chandigarh University, India There is no new data generated. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Private Academic Consultant, Phonhong, Lao People's Democratic Republic. E-mail address: [email protected] (H. Daungsupawong). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Continuous Kalman Estimation Method for Finger Kinematics Tracking from Surface Electromyography
Authors: Haoshi Zhang, Boxing Peng, Lan Tian, Oluwarotimi Williams Samuel, Guanglin Li
Journal: Cyborg and Bionic Systems (2024)

Deciphering hand motion intention from surface electromyography (sEMG) encounters challenges posed by the requisites of multiple degrees of freedom (DOFs) and adaptability. Unlike discrete action classification grounded in pattern recognition, the pursuit of continuous kinematics estimation is appreciated for its inherent naturalness and intuitiveness. However, prevailing estimation techniques contend with accuracy limitations and substantial computational demands. Kalman estimation technology, celebrated for its ease of implementation and real-time adaptability, finds extensive application across diverse domains. This study introduces a continuous Kalman estimation method, leveraging a system model with sEMG and joint angles as inputs and outputs. Facilitated by model parameter training methods, the approach deduces multiple DOF finger kinematics simultaneously. The method’s efficacy is validated using a publicly accessible database, yielding a correlation coefficient (CC) of 0.73. With over 45,000 windows for training Kalman model parameters, the average computation time remains under 0.01 s. This pilot study amplifies its potential for further exploration and application within the realm of continuous finger motion estimation technology.
Coaches of youth field sports as delivery agents of injury prevention programmes: how are we training the trainers? A scoping review
Authors: Lauren Guilfoyle, Ian C Kenny, Kieran O'Sullivan, Mark J Campbell, Giles D Warrington, Liam G Glynn, Tom Comyns
Journal: British Journal of Sports Medicine (2024)

Objective To systematically map the coach education (CE) component of injury prevention programmes (IPPs) for youth field sports by identifying and synthesising the design, content and facilitation strategies used to address competency drivers and behaviour change. Design Scoping review. Data sources PubMed, PsycInfo, EMBASE, CINAHL, SportDiscus and Google Scholar electronic databases were searched using keywords related to IPPs and youth field sports. Eligibility criteria for selecting studies Studies of IPPs in youth field sports, that provided ‘train-the-trainer’ education to coaches as designated delivery agents. Results 20 studies from two field sports (soccer/football; n=17, Rugby Union; n=3) fulfilled the eligibility criteria. Eleven CE interventions occurred in the preseason and 18 occurred at one time-point (single day). Five studies cited use of a behavioural change theory or model in the design of their CE, most frequently the Health Action Process Approach model (n=5); and use of behavioural change techniques varied. Twelve of twenty studies (60%) reported some form of ongoing support to coaches following the CE primary intervention concurrent with IPP implementation. Conclusion CE that occurs on 1 day (one time-point) is most popular for preparing coaches as delivery agents of IPPs in youth field sports. While recognising pragmatic barriers, more expansive in-service training, support and feedback may enhance the effective implementation of IPPs. Trial registration number https://doi.org/10.17605/OSF.IO/FMHGD
p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL
Authors: Hwang Chan Yu, Yong Geun Jeon, Ann-Yae Na, Chang Yeob Han, Mi Rin Lee, Jae Do Yang, Hee Chul Yu, Jung Beom Son, Nam Doo Kim, Jae Bum Kim, Sangkyu Lee, Eun Ju Bae, Byung-Hyun Park
Journal: Nature Metabolism (2024)
Finite-Time Topology Identification of Delayed Complex Dynamical Networks and Its Application
Authors: Yu Chen, Zhi-Wei Liu, Yuzhen Qin
Journal: Cyborg and Bionic Systems (2024)

To understand the functional behaviors of systems built on networks, it is essential to determine the uncertain topology of these networks. Traditional synchronization-based topology identification methods generally converge asymptotically or exponentially, resulting in their inability to give timely identification results. The finite-time stability theory is adopted in this paper with the aim of addressing the problem of fast identification of uncertain topology in networks. A novel finite-time topology observer is proposed to achieve finite-time topology identification and synchronization of general complex dynamical networks with time delay and second-order dynamical networks with time delay and nonlinear coupling. In addition, the proposed finite-time identification method is applied to power grids to address the problem of fast detection of line outages. Finally, 2 numerical experiments are provided to demonstrate the effectiveness and rapidity of the proposed finite-time identification method.
Hybrid Directed Hypergraph Learning and Forecasting of Skeleton-Based Human Poses
Authors: Qiongjie Cui, Zongyuan Ding, Fuhua Chen
Journal: Cyborg and Bionic Systems (2024)

Forecasting 3-dimensional skeleton-based human poses from the historical sequence is a classic task, which shows enormous potential in robotics, computer vision, and graphics. Currently, the state-of-the-art methods resort to graph convolutional networks (GCNs) to access the relationships of human joint pairs to formulate this problem. However, human action involves complex interactions among multiple joints, which presents a higher-order correlation overstepping the pairwise (2-order) connection of GCNs. Moreover, joints are typically activated by the parent joint, rather than driving their parent joints, whereas in existing methods, this specific direction of information transmission is ignored. In this work, we propose a novel hybrid directed hypergraph convolution network (H-DHGCN) to model the high-order relationships of the human skeleton with directionality. Specifically, our H-DHGCN mainly involves 2 core components. One is the static directed hypergraph, which is pre-defined according to the human body structure, to effectively leverage the natural relations of human joints. The second is dynamic directed hypergraph (D-DHG). D-DHG is learnable and can be constructed adaptively, to learn the unique characteristics of the motion sequence. In contrast to the typical GCNs, our method brings a richer and more refined topological representation of skeleton data. On several large-scale benchmarks, experimental results show that the proposed model consistently surpasses the latest techniques.
Current myositis clinical trials and tribulations
Authors: Didem Saygin, Victoria Werth, Julie J Paik, Jin Kyun Park, Merrilee Needham, Ingrid E Lundberg, Lisa Christopher-Stine
Journal: Annals of the Rheumatic Diseases (2024)

With improved understanding of disease pathogenesis and availability of outcome measures, there has been a remarkable increase in the number of therapeutic clinical trials in idiopathic inflammatory myopathies (myositis) over the last three years reaching as many as five trials per site. These trials share similar design and inclusion/exclusion criteria resulting in a competitive clinical trial landscape in myositis. While these are exciting times for the myositis field, we have a number of concerns about the design and conduct of the myositis trials. These include competitive landscape, lengthy placebo arms, underrepresentation of minority groups among participants, use of patient reported outcome measures with limited/no data on validity in myositis, antiquated disease classification criteria, and unclear performance of the ACR/EULAR Myositis Response Criteria in skin-predominant patients despite inclusion of these patients in trials. In this viewpoint, we further discuss these concerns and offer potential solutions such as including patient perspectives in the trial design and adoption of innovative frameworks.
A commentary on ‘Neurosurgical application of pineal region tumor resection with 3D 4K exoscopy via infratentorial approach: a retrospective cohort study’
Authors: Jiahua Zhou, Di Yang, Dayun Feng, Huaizhou Qin, Chao Wang
Journal: International Journal of Surgery (2024)

aDepartment of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shanxi, 710038,China 2Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, Shanxi, 710038,China Co-authors: Jiahua Zhou and Di Yang equally contributed to the article. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding Author. Address: Department of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shanxi, 710038, China. E-mail address: [email protected] (C. Wang). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A commentary on ‘Survival benefit of liver resection following complete response to transarterial chemoembolization for intermediate-stage hepatocellular carcinoma: a retrospective, multicenter, cohort study’
Authors: Fengwei Gao, Xin Zhao, Qingyun Xie, Jiayin Yang, Hong Wu
Journal: International Journal of Surgery (2024)

Gao, Fengwei MD; Zhao, Xin MM; Xie, Qingyun MM; Yang, Jiayin MD; Wu, Hong MD Author Information
The forecasted prevalence of comorbidities and multimorbidity in people with HIV in the United States through the year 2030: A modeling study
Authors: Keri N. Althoff, Cameron Stewart, Elizabeth Humes, Lucas Gerace, Cynthia Boyd, Kelly Gebo, Amy C. Justice, Emily P. Hyle, Sally B. Coburn, Raynell Lang, Michael J. Silverberg, Michael A. Horberg, Viviane D. Lima, M. John Gill, Maile Karris, Peter F. Rebeiro, Jennifer Thorne, Ashleigh J. Rich, Heidi Crane, Mari Kitahata, Anna Rubtsova, Cherise Wong, Sean Leng, Vincent C. Marconi, Gypsyamber D’Souza, Hyang Nina Kim, Sonia Napravnik, Kathleen McGinnis, Gregory D. Kirk, Timothy R. Sterling, Richard D. Moore, Parastu Kasaie
Journal: PLoS Medicine (2024)

Estimating the medical complexity of people aging with HIV can inform clinical programs and policy to meet future healthcare needs. The objective of our study was to forecast the prevalence of comorbidities and multimorbidity among people with HIV (PWH) using antiretroviral therapy (ART) in the United States (US) through 2030.
The emergence and implications of SARS-CoV-2 omicron subvariant BA.2.86 on global health
Authors: Prakasini Satapathy, Pawan Kumar, Jeetendra K. Gupta, Ali A. Rabaan, Nawal A. Al Kaabi, Dibyalochan Mohanty, Pathakala Naveen, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Quazi Syed Zahiruddin, Ahmad Neyazi
Journal: International Journal of Surgery (2024)

The SARS-CoV-2 subvariant BA.2.86 ‘Pirola’, first identified in Denmark in August 2023, has manifested with a significantly mutated spike protein profile, suggesting a heightened ability to evade vaccine-induced and infection-induced antibodies. This article outlines the epidemiological spread, immune response implications, and global responses to BA.2.86. Preliminary observations indicate community transmissions of the subvariant, even among those previously infected or vaccinated. Notably, the BA.2.86 infection has shown a potential to amplify antibody responses. The variant’s emergence has evoked memories of the Omicron variant’s rise in late 2021, though global immunity levels might modulate the impact of BA.2.86 impact differently. Continuous genomic surveillance, coupled with integrated diagnostic and epidemiological strategies, proves crucial in early detection and management. The emergence of BA.2.86 reaffirms the unpredictable nature of the COVID-19 pandemic, emphasizing the need for ongoing research, adaptability, and global collaboration.