tbuckley/cabot-search huggingface dataset:
A sex- and gender-based analysis of alcohol treatment intervention research involving youth: A methodological systematic review
Authors: A.J. Lowik, Caroline Mniszak, Michelle Pang, Kimia Ziafat, Mohammad Karamouzian, Rod Knight
Journal: PLoS Medicine (2024)

Background While there is widespread consensus that sex- and gender-related factors are important for how interventions are designed, implemented, and evaluated, it is not currently known how alcohol treatment research accounts for sex characteristics and/or gender identities and modalities. This methodological systematic review documents and assesses how sex characteristics, gender identities, and gender modalities are operationalized in alcohol treatment intervention research involving youth. Methods and findings We searched MEDLINE, Embase, Cochrane Central Registry of Controlled Trials, PsycINFO, CINAHL, LGBT Life, Google Scholar, Web of Science, and grey literature from 2008 to 2023. We included articles that reported genders and/or sexes of participants 30 years of age and under and screened participants using AUDIT, AUDIT-C, or a structured interview using DSM-IV criteria. We limited the inclusion to studies that enrolled participants in alcohol treatment interventions and used a quantitative study design. We provide a narrative overview of the findings. Of 8,019 studies screened for inclusion, 86 articles were included in the review. None of the studies defined, measured, and reported both sex and gender variables accurately. Only 2 studies reported including trans participants. Most of the studies used gender or sex measures as a covariate to control for the effects of sex or gender on the intervention but did not discuss the rationale for or implications of this procedure. Conclusions Our findings identify that the majority of alcohol treatment intervention research with youth conflate sex and gender factors, including terminologically, conceptually, and methodologically. Based on these findings, we recommend future research in this area define and account for a spectrum of gender modalities, identities, and/or sex characteristics throughout the research life cycle, including during study design, data collection, data analysis, and reporting. It is also imperative that sex and gender variables are used expansively to ensure that intersex and trans youth are meaningfully integrated. Trial registration Registration: PROSPERO, registration number: CRD42019119408
Incorporating Supramaximal Resection into Survival Stratification of IDH-wildtype Glioblastoma: A Refined Multi-institutional Recursive Partitioning Analysis
Authors: Yae Won Park, Kyu Sung Choi, Martha Foltyn-Dumitru, Gianluca Brugnara, Rouzbeh Banan, Sooyon Kim, Kyunghwa Han, Ji Eun Park, Tobias Kessler, Martin Bendszus, Sandro Krieg, Wolfgang Wick, Felix Sahm, Seung Hong Choi, Ho Sung Kim, Jong Hee Chang, Se Hoon Kim, Doonyaporn Wongsawaeng, Jeffrey Michael Pollock, Seung-Koo Lee, Ramon Francisco Barajas, Philipp Vollmuth, Sung Soo Ahn
Journal: Clinical Cancer Research (2024)

To propose a novel recursive partitioning analysis (RPA) classification model in patients with IDH-wildtype glioblastomas that incorporates the recently expanded conception of the extent of resection (EOR) in terms of both supramaximal and total resections. This multicenter cohort study included a developmental cohort of 622 patients with IDH-wildtype glioblastomas from a single institution (Severance Hospital) and validation cohorts of 536 patients from three institutions (Seoul National University Hospital, Asan Medical Center, and Heidelberg University Hospital). All patients completed standard treatment including concurrent chemoradiotherapy and underwent testing to determine their IDH mutation and MGMTp methylation status. EORs were categorized into either supramaximal, total, or non-total resections. A novel RPA model was then developed and compared with a previous Radiation Therapy Oncology Group (RTOG) RPA model. In the developmental cohort, the RPA model included age, MGMTp methylation status, Karnofsky performance status, and EOR. Younger patients with MGMTp methylation and supramaximal resections showed a more favorable prognosis [class I: median overall survival (OS) 57.3 months], whereas low-performing patients with non-total resections and without MGMTp methylation showed the worst prognosis (class IV: median OS 14.3 months). The prognostic significance of the RPA was subsequently confirmed in the validation cohorts, which revealed a greater separation between prognostic classes for all cohorts compared with the previous RTOG RPA model. The proposed RPA model highlights the impact of supramaximal versus total resections and incorporates clinical and molecular factors into survival stratification. The RPA model may improve the accuracy of assessing prognostic groups. See related commentary by Karschnia et al., p. 4811.
Prevalence of urinary incontinence in Brazilian para athletes
Authors: Pê Nascimento Barbosa, Marina Petter Rodrigues, Anselmo de Athayde Costa e Silva, Carla Iasmin Lima Lemos, Marília Passos Magno e Silva
Journal: British Journal of Sports Medicine (2024)

To describe the prevalence of urinary incontinence (UI) in para athletes in Brazil.
Hearing loss in Australian First Nations children at 6-monthly assessments from age 12 to 36 months: Secondary outcomes from randomised controlled trials of novel pneumococcal conjugate vaccine schedules
Authors: Amanda Jane Leach, Nicole Wilson, Beth Arrowsmith, Jemima Beissbarth, Kim Mulholland, Mathuram Santosham, Paul John Torzillo, Peter McIntyre, Heidi Smith-Vaughan, Sue A. Skull, Victor M. Oguoma, Mark D. Chatfield, Deborah Lehmann, Christopher G. Brennan-Jones, Michael J. Binks, Paul V. Licciardi, Ross M. Andrews, Tom Snelling, Vicki Krause, Jonathan Carapetis, Anne B. Chang, Peter Stanley Morris
Journal: PLoS Medicine (2024)

In Australian remote communities, First Nations children with otitis media (OM)-related hearing loss are disproportionately at risk of developmental delay and poor school performance, compared to those with normal hearing. Our objective was to compare OM-related hearing loss in children randomised to one of 2 pneumococcal conjugate vaccine (PCV) formulations.
Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial final results
Authors: Changsong Qi, Chang Liu, Jifang Gong, Dan Liu, Xicheng Wang, Panpan Zhang, Yanru Qin, Sai Ge, Miao Zhang, Zhi Peng, Jun Zhou, Zhihao Lu, Ming Lu, Yanshuo Cao, Jiajia Yuan, Yakun Wang, Zhenghang Wang, Ran Xue, Xiaohui Peng, Yumeng Wang, Daijing Yuan, Jian Li, Xiaotian Zhang, Lin Shen
Journal: Nature Medicine (2024)
Association of Psychiatric Emergency Visits and Warm Ambient Temperature during Pregnancy: A Time-Stratified Case-Crossover Study
Authors: Jennifer D. Runkle, Margaret M. Sugg, Anne Berry, Charlie Reed, Kristen Cowan, Luke Wertis, Sophie Ryan
Journal: Environmental Health Perspectives (2024)

Acute exposure to high ambient temperature and heat waves during the warm season has been linked with psychiatric disorders. Emerging research has shown that pregnant people, due to physiological and psychological changes, may be more sensitive to extreme heat, and acute exposure has been linked to increased risk of pregnancy complications; however, few studies have examined psychiatric complications.
The Joint Effects of Thunderstorms and Power Outages on Respiratory-Related Emergency Visits and Modifying and Mediating Factors of This Relationship
Authors: Shao Lin, Quan Qi, Han Liu, Xinlei Deng, Ian Trees, Xiaojun Yuan, Mary P. Gallant
Journal: Environmental Health Perspectives (2024)

While limited studies have evaluated the health impacts of thunderstorms and power outages (POs) separately, few have assessed their joint effects. We aimed to investigate the individual and joint effects of both thunderstorms and POs on respiratory diseases, to identify disparities by demographics, and to examine the modifications and mediations by meteorological factors and air pollution. Distributed lag nonlinear models were used to examine exposures during three periods (i.e., days with both thunderstorms and POs, thunderstorms only, and POs only) in relation to emergency department visits for respiratory diseases (2005-2018) compared to controls (no thunderstorm/no PO) in New York State (NYS) while controlling for confounders. Interactions between thunderstorms and weather factors or air pollutants on health were assessed. The disparities by demographics and seasons and the mediative effects by particulate matter with aerodynamic diameter ≤2.5μm (PM2.5) and relative humidity (RH) were also evaluated. Thunderstorms and POs were independently associated with total and six subtypes of respiratory diseases in NYS [highest risk ratio (RR) = 1.12; 95% confidence interval (CI): 1.08, 1.17], but the impact was stronger when they co-occurred (highest RR = 1.44; 95% CI: 1.22, 1.70), especially during grass weed, ragweed, and tree pollen seasons. The stronger thunderstorm/PO joint effects were observed on chronic obstructive pulmonary diseases, bronchitis, and asthma (lasted 0-10 d) and were higher among residents who lived in rural areas, were uninsured, were of Hispanic ethnicity, were 6-17 or over 65 years old, and during spring and summer. The number of comorbidities was significantly higher by 0.299-0.782/case. Extreme cold/heat, high RH, PM2.5, and ozone concentrations significantly modified the thunderstorm-health effect on both multiplicative and additive scales. Over 35% of the thunderstorm effects were mediated by PM2.5 and RH. Thunderstorms accompanied by POs showed the strongest respiratory effects. There were large disparities in thunderstorm-health associations by demographics. Meteorological factors and air pollution levels modified and mediated the thunderstorm-health effects. https://doi.org/10.1289/EHP13237.
Integrating Clinical Trials and Practice
Authors: Gregory Curfman
Journal: JAMA (2024)

Derek C. Angus, MD, MPH; Alison J. Huang, MD, MAS; Roger J. Lewis, MD, PhD; Amy P. Abernethy, MD, PhD; Robert M. Califf, MD; Martin Landray, PhD; Nancy Kass, ScD; Kirsten Bibbins-Domingo, PhD, MD, MAS; JAMA Summit on Clinical Trials Participants; Ali B Abbasi; Kaleab Z Abebe; Amy P Abernethy; Stacey J. Adam; Derek C Angus; Jamy Ard; Rachel A Bender Ignacio ; Scott M Berry; Deepak L. Bhatt; Kirsten Bibbins-Domingo; Robert O. Bonow; Marc Bonten; Sharon A. Brangman; John Brownstein; Melinda J. B. Buntin; Atul J Butte; Robert M. Califf; Marion K Campbell; Anne R. Cappola; Anne C Chiang; Deborah Cook; Steven R Cummings; Gregory Curfman; Laura J Esserman; Lee A Fleisher; Joseph B Franklin; Ralph Gonzalez; Cynthia I Grossman; Tufia C. Haddad; Roy S. Herbst; Adrian F. Hernandez; Diane P Holder; Leora Horn; Grant D. Huang; Alison Huang; Nancy Kass; Rohan Khera; Walter J. Koroshetz; Harlan M. Krumholz; Martin Landray; Roger J. Lewis; Tracy A Lieu; Preeti N. Malani; Christa Lese Martin; Mark McClellan; Mary M. McDermott; Stephanie R. Morain; Susan A Murphy; Stuart G Nicholls; Stephen J Nicholls; Peter J. O'Dwyer; Bhakti K Patel; Eric Peterson; Sheila A. Prindiville; Joseph S. Ross; Kathryn M Rowan; Gordon Rubenfeld; Christopher W. Seymour; Rod S Taylor; Joanne Waldstreicher; Tracy Y. Wang
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption
Authors: Mengyi Yan, Xiayun Chen, Xiaotong Li, Qianqian Liu, Baixue Yu, Yi Cen, Wei Zhang, Yibin Liu, Xinxuan Li, Ying Chen, Tao Wang, Shiying Li
Journal: Acta Pharmaceutica Sinica B (2024)

The immunosuppressive phenotype of tumor cells extensively attenuates the immune activation effects of traditional treatments. In this work, a transferrin receptor (TfR) targeted immunostimulant (PTI) is fabricated for photodynamic immunotherapy against metastatic tumors by interrupting
Synthesis and evaluation of TSPO-targeting radioligand [18F]F-TFQC for PET neuroimaging in epileptic rats
Authors: Wenhui Fu, Qingyu Lin, Zhequan Fu, Tingting Yang, Dai Shi, Pengcheng Ma, Hongxing Su, Yunze Wang, Guobing Liu, Jing Ding, Hongcheng Shi, Dengfeng Cheng
Journal: Acta Pharmaceutica Sinica B (2024)

The translocator protein (TSPO) positron emission tomography (PET) can noninvasively detect neuroinflammation associated with epileptogenesis and epilepsy. This study explored the role of the TSPO-targeting radioligand [18F]F-TFQC, an m-trifluoromethyl ER176 analog, in the PET neuroimaging of epileptic rats. Initially, [18F]F-TFQC was synthesized with a radiochemical yield of 8%–10% (EOS), a radiochemical purity of over 99%, and a specific activity of 38.21 ± 1.73 MBq/nmol (EOS). After determining that [18F]F-TFQC exhibited good biochemical properties, [18F]F-TFQC PET neuroimaging was performed in epileptic rats at multiple time points in various stages of disease progression. PET imaging showed specific [18F]F-TFQC uptake in the right hippocampus (KA-injected site, i.e., epileptogenic zone), which was most pronounced at 1 week (T/NT 1.63 ± 0.21) and 1 month (T/NT 1.66 ± 0.20). The PET results were further validated using autoradiography and pathological analysis. Thus, [18F]F-TFQC can reflect the TSPO levels and localize the epileptogenic zone, thereby offering the potential for monitoring neuroinflammation and guiding anti-inflammatory treatment in patients with epilepsy.
Evidence for dynastic succession among early Celtic elites in Central Europe
Authors: Joscha Gretzinger, Felicitas Schmitt, Angela Mötsch, Selina Carlhoff, Thiseas Christos Lamnidis, Yilei Huang, Harald Ringbauer, Corina Knipper, Michael Francken, Franziska Mandt, Leif Hansen, Cäcilia Freund, Cosimo Posth, Hannes Rathmann, Katerina Harvati, Günther Wieland, Lena Granehäll, Frank Maixner, Albert Zink, Wolfram Schier, Dirk Krausse, Johannes Krause, Stephan Schiffels
Journal: Nature Human Behaviour (2024)

The early Iron Age (800 to 450 BCE) in France, Germany and Switzerland, known as the 'West-Hallstattkreis', stands out as featuring the earliest evidence for supra-regional organization north of the Alps. Often referred to as 'early Celtic', suggesting tentative connections to later cultural phenomena, its societal and population structure remain enigmatic. Here we present genomic and isotope data from 31 individuals from this context in southern Germany, dating between 616 and 200 BCE. We identify multiple biologically related groups spanning three elite burials as far as 100 km apart, supported by trans-regional individual mobility inferred from isotope data. These include a close biological relationship between two of the richest burial mounds of the Hallstatt culture. Bayesian modelling points to an avuncular relationship between the two individuals, which may suggest a practice of matrilineal dynastic succession in early Celtic elites. We show that their ancestry is shared on a broad geographic scale from Iberia throughout Central-Eastern Europe, undergoing a decline after the late Iron Age (450 BCE to ~50 CE).
The BTLA–HVEM axis restricts CAR T cell efficacy in cancer
Authors: Puneeth Guruprasad, Alberto Carturan, Yunlin Zhang, Jong Hyun Cho, Kingsley Gideon Kumashie, Ruchi P. Patel, Ki-Hyun Kim, Jong-Seo Lee, Yoon Lee, Jong Hoon Kim, Junho Chung, Akshita Joshi, Ivan Cohen, Maksim Shestov, Guido Ghilardi, Jaryse Harris, Raymone Pajarillo, Mathew Angelos, Yong Gu Lee, Shan Liu, Jesse Rodriguez, Michael Wang, Hatcher J. Ballard, Aasha Gupta, Ositadimma H. Ugwuanyi, Seok Jae Albert Hong, Audrey C. Bochi-Layec, Christopher T. Sauter, Linhui Chen, Luca Paruzzo, Shane Kammerman, Olga Shestova, Dongfang Liu, Laura A. Vella, Stephen J. Schuster, Jakub Svoboda, Patrizia Porazzi, Marco Ruella
Journal: Nature Immunology (2024)
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus
Authors: Mahmoud Al-Azab, Elina Idiiatullina, Ziyang Liu, Meng Lin, Katja Hrovat-Schaale, Huifang Xian, Jianheng Zhu, Mandy Yang, Bingtai Lu, Zhiyao Zhao, Yiyi Liu, Jingjie Chang, Xiaotian Li, Caiqin Guo, Yunfeng Liu, Qi Wu, Jiazhang Chen, Chaoting Lan, Ping Zeng, Jun Cui, Xia Gao, Wenhao Zhou, Yan Zhang, Yuxia Zhang, Seth L. Masters
Journal: Nature Immunology (2024)

Abstract Rare genetic variants in toll-like receptor 7 (TLR7) are known to cause lupus in humans and mice. UNC93B1 is a transmembrane protein that regulates TLR7 localization into endosomes. In the present study, we identify two new variants in UNC93B1 (T314A, located proximally to the TLR7 transmembrane domain, and V117L) in a cohort of east Asian patients with childhood-onset systemic lupus erythematosus. The V117L variant was associated with increased expression of type I interferons and NF-κB-dependent cytokines in patient plasma and immortalized B cells. THP-1 cells expressing the variant UNC93B1 alleles exhibited exaggerated responses to stimulation of TLR7/-8, but not TLR3 or TLR9, which could be inhibited by targeting the downstream signaling molecules, IRAK1/-4. Heterozygous mice expressing the orthologous Unc93b1 V117L variant developed a spontaneous lupus-like disease that was more severe in homozygotes and again hyperresponsive to TLR7 stimulation. Together, this work formally identifies genetic variants in UNC93B1 that can predispose to childhood-onset systemic lupus erythematosus.
Higher Genetic Risk for Type 2 Diabetes Is Associated With a Faster Decline of β-Cell Function in an East Asian Population
Authors: Hyunsuk Lee, Jaewon Choi, Jong-Il Kim, Richard M. Watanabe, Nam H. Cho, Kyong Soo Park, Soo Heon Kwak
Journal: Diabetes Care (2024)

While most genetic variants of type 2 diabetes (T2D) are suggested to be associated with β-cell dysfunction cross sectionally, their association with the longitudinal change of β-cell function remains largely unknown.
ALK+/EGFRm NSCLC: Lorlatinib Wows; Toward Sub-Q Amivantamab
Authors: Alissa Poh
Journal: Cancer Discovery (2024)

Findings from two phase III trials, CROWN and PALOMA-3, respectively reaffirm third-generation ALK inhibitor lorlatinib's first-line place in the treatment arsenal for ALK–positive non–small cell lung cancer, and suggest that a subcutaneous formulation of the EGFR–MET bispecific amivantamab is no less effective than intravenous infusion, substantially reducing treatment time and toxicity.
Long Noncoding RNAs in Single Cells
Authors: Qiongzi Qiu, Mingyu Liang
Journal: Journal of the American Society of Nephrology (2024)

Department of Physiology, University of Arizona College of Medicine – Tucson, Tucson, Arizona Correspondence: Dr. Mingyu Liang, email: [email protected] See related article, "Cell Type– and Age-Specific Expression of lncRNAs across Kidney Cell Types," on pages XXX–XXX.
The influence of threat on visuospatial perception, affordances, and protective behaviour: A systematic review and meta-analysis
Authors: Erin MacIntyre, Eleana Pinto, Brendan Mouatt, Michael L. Henry, Christopher Lamb, Felicity A. Braithwaite, Ann Meulders, Tasha R. Stanton
Journal: Clinical Psychology Review (2024)

Perception has been conceptualised as an active and adaptive process, based upon incoming sensory inputs, which are modified by top-down factors such as cognitions. Visuospatial perception is thought to be scaled based on threat, with highly threatening objects or contexts visually inflated to promote escape or avoidance behaviours. This meta-analytical systematic review quantified the effect and evidence quality of threat-evoked visuospatial scaling, as well as how visuospatial scaling relates to affordances (perceived action capabilities) and behavioural avoidance/escape outcomes. Databases and grey literature were systematically searched inclusive to 10/04/24. Studies were assessed with a customised Risk of Bias form and meta-analysis was performed using a random-effects model. 12,354 records were identified. Of these, 49 experiments (n = 3027) were included in the review. There was consistent evidence that threat the of height influenced contextual perception (g = 0.66, 95% CI: 0.45, 0.88) and affordances (g = -0.43, 95% CI: -0.84, -0.03). Threatening objects were viewed as larger (g = 0.76, 95% CI: 0.26, 1.26) and as closer (g = 0.30, 95% CI: 0.17, 0.42). Bodily threat (pain) yielded conflicting effects on visuospatial perception/affordances. We conclude that threat may influence visuospatial perception and affordances. However, since behavioural measures were poorly reported, their relationship with visuospatial perception/affordances remains elusive.
T2-FLAIR mismatch sign predicts DNA methylation subclass and <i>CDKN2A/B</i> status in <i>IDH</i>-mutant astrocytomas
Authors: Matthew D. Lee, Rajan Jain, Kristyn Galbraith, Anna Chen, Evan Lieberman, Sohil H. Patel, Dimitris G. Placantonakis, David Zagzag, Marissa Barbaro, Maria del Pilar Guillermo Prieto Eibl, John G. Golfinos, Daniel A. Orringer, Matija Snuderl
Journal: Clinical Cancer Research (2024)

Abstract Purpose: DNA methylation profiling stratifies isocitrate dehydrogenase (IDH)-mutant astrocytomas into methylation low- and high-grade groups. We investigated the utility of the T2-fluid-attenuated inversion recovery (T2-FLAIR) mismatch sign for predicting DNA methylation grade and cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) homozygous deletion, a molecular biomarker for grade 4 IDH-mutant astrocytomas, according to the 2021 World Health Organization classification. Experimental Design: Preoperative MRI scans of IDH-mutant astrocytomas subclassified by DNA methylation profiling (n = 71) were independently evaluated by two radiologists for the T2-FLAIR mismatch sign. The diagnostic utility of T2-FLAIR mismatch in predicting methylation grade, CDKN2A/B status, copy number variation, and survival was analyzed. Results: The T2-FLAIR mismatch sign was present in 21 of 45 (46.7%) methylation low-grade and 1 of 26 (3.9%) methylation high-grade cases (P &amp;lt; 0.001), resulting in 96.2% specificity, 95.5% positive predictive value, and 51.0% negative predictive value for predicting low methylation grade. The T2-FLAIR mismatch sign was also significantly associated with intact CDKN2A/B status (P = 0.028) with 87.5% specificity, 86.4% positive predictive value, and 42.9% negative predictive value. Overall multivariable Cox analysis showed that retained CDKN2A/B status remained significant for progression-free survival (P = 0.01). Multivariable Cox analysis of the histologic grade 3 subset, which was nearly evenly divided by CDKN2A/B status, copy number variation, and methylation grade, showed trends toward significance for DNA methylation grade with overall survival (P = 0.045) and CDKN2A/B status with progression-free survival (P = 0.052). Conclusions: The T2-FLAIR mismatch sign is highly specific for low methylation grade and intact CDKN2A/B in IDH-mutant astrocytomas.