tbuckley/cabot-search huggingface dataset:
Two-year outcome of social skills training and group psychotherapy for outpatients with schizophrenia
Authors: Stephen R. Marder, William C. Wirshing, Jim Mintz, Joanne McKenzie, Kathleen Johnston, Thad A. Eckman, Malca Lebell, Karin Zimmerman, Robert P. Liberman
Journal: American Journal of Psychiatry (1996)

The authors evaluated the effectiveness of behaviorally oriented social skills training and supportive group therapy for improving the social adjustment of schizophrenic patients living in the community and for protecting them against psychotic relapse.Eighty male outpatients with schizophrenia were stabilized with a low dose of fluphenazine decanoate (5 to 10 mg every 14 days), which was supplemented with oral fluphenazine (5 mg twice daily) or a placebo when they first met criteria for a prodromal period. (Half of the patients did so at some time during the study.) Patients were randomly assigned to receive either social skills training or supportive group therapy twice weekly for 6 months and then weekly for the next 18 months. Rates of psychotic exacerbation were monitored, as were scores on the Social Adjustment Scale II.There were significant main effects favoring social skills training over supportive group therapy on two of the six Social Adjustment Scale II cluster totals examined (personal well-being and total) and significant interactions between psychosocial treatment and drug treatment for three items (external family, social and leisure activities, and total). In each case, these interactions indicated that the advantage of social skills training over supportive group therapy was greatest when it was combined with active drug supplementation. Social skills training did not significantly decrease the risk of psychotic exacerbation in the full group, but an advantage was observed (post hoc) among patients who received placebo supplementation.These findings suggest that social skills training resulted in greater improvement in certain measures of social adjustment than supportive group therapy. The greatest improvement in social outcomes occurred when social skills training was combined with a pharmacological strategy of active drug supplementation at the time prodromal worsening of psychotic symptoms was first observed. However, these improvements were modest in absolute terms and confined to certain subgroups of patients.
Die Nierenkrankheiten in der Praxis.
Authors: Carl Robert Schlayer
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physical Methods in Physiology.
Authors: William Thorpe Catton
Journal: Annals of Internal Medicine (1958)

Unlike its prototypes, McAuliffe's "Practical Otolaryn- gology" designated as a handbook for the general practi- tioner, is not a standard abridgement.It is, rather, a well organized compilation of gleanings from many years of practice and teaching.Much of its value is derived from the unorthodox style of exposition employed by the author.This book offers a great deal of information concerning practical approaches to diagnosis and therapy of common otolaryngologic diseases.The presentation of this material is similar to what might be encountered in brief, intimate, clinical conferences in a postgraduate course.While many of this book's virtues lie in its brevity, so do most of its faults; in many of the passages its conciseness tends to be misleading or confusing.The work is studded with categorical statements of a controversial nature.For example, Dr. McAuliffe recommends the use of novobiocin (referred to in the text by a trade name) in traumatic perforations of the tympanic membrane.Dr. McAuliffe illustrates his material with his own admir- able line drawings.More of these should have been included.Many of the other illustrations, especially the photographs of the "McAuliffe Aerosol Machine" and the "McAuliffe Wet Suction Apparatus for Treatment and Diagnostic Irri- gation of the Tonsil," could well have been deleted.(An entire chapter is devoted to the "McAuliffe Wet Suction Apparatus."Since this device, which was originally reported by the author in 1931, has not gained acceptance by oto- laryngologists, the inclusion of a chapter describing it to the general practitioner seems to be injudicious.)Despite these criticisms, this book is recommended to the general practitioner, so much of whose work is in ear, nose, and throat.The handbook would also be helpful to medical students, interns, and residents in fields other than otolaryngology.
Study Hgb-205: Outcomes of Gene Therapy for Hemoglobinopathies Via Transplantation of Autologous Hematopoietic Stem Cells Transduced Ex Vivo with a Lentiviral βΑ-T87Q-Globin Vector (LentiGlobin® BB305 Drug Product)
Authors: Marina Cavazzana, Jean-Antoine Ribeil, Emmanuel Payen, Felipe Suarez, Yves Beuzard, Fabien Touzot, Resy Cavallesco, Francois Lefrère, Stany Chretien, Phillipe Bourget, Fabrice Monpoux, Corrine Pondarre, Benedicte Neven, Manfred Schmidt, Christof von Kalle, Laura Sandler, Sandeep Soni, Olivier Hermine, Stephanie Blanche, Mariane De Montalembert, Salima Hacein-Bey-Abina, Philippe Leboulch
Journal: Blood (2014)
Über die Darstellung des zentralen und peripheren Nervensystems im Röntgenbild
Authors: Walter Jacobi, Wilhelm Löhr, Otto Wustmann, Julius Hallervorden
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2664: Clinical Outcome and Left Ventricular Contractile Function After Distal Protection in Primary Percutaneous Coronary Intervention The Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction (DEDICATION) Trial
Authors: Klaus F Kofoed, Henning Kelbæk, Leif Thuesen, Steen H Poulsen, Christian Hassager, Niels H Andersen, Steffen Helqvist, Jens F Lassen, Peter Clemmensen, Lene Kløvgaard, Anne Kaltoft, Thomas Engstrøm, Lars R Krusell, Christian J Terkelsen, Lars Køber
Journal: Circulation (2008)

Objective Embolization of material from an infarct-related lesion during percutaneous coronary intervention (PCI) may result in an increased infarct size. We evaluated the effect of distal protection during PCI for ST-segment elevation myocardial infarction (STEMI) on clinical outcome and myocardial function. Methods and results Patients with STEMI were randomly referred within 12 hours for PCI with (n = 312) or without distal protection (n = 314). Left ventricular (LV) contractile function was assessed with echocardiography 8 month after PCI. Global LV myocardial wall motion index (WMI) was calculated as the average wall motion score of all myocardial segments. Major adverse cardiac and cerebral events (MACCE) 8 months after PCI was 7.1 % after distal protection and 5.7 % after conventional treatment (p = 0.17). WMI improved by 4.1% at 8 months in patients treated with distal protection compared to patients receiving conventional PCI (p&lt;0.01). In myocardium subtended by culprit coronary vessels treated with distal protection regional LV function was 9 –11% higher than myocardial regions treated conventionally (p&lt;0.02). Conclusion Routine use of distal protection during primary PCI is associated with a significant improvement in LV contractile function, with no detectable impact on intermediate term clinical outcome.
The New Dietetics. A Guide to Scientific Feeding in Health and Disease.
Authors: John Harvey Kellogg
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Central Nervous System Metastases in Small Cell Carcinoma of the Lung — A Review
Authors: F. R. Hirsch, H. H. Hansen, O. B. Paulson
Journal: Neuro-Oncology (1980)

Small cell anaplastic carcinoma of the lung (SCCL) constitutes 20–25% of all malignant lung tumours. It is biologically known to be characterized by a number of clinical features which separate it from epidermoid carcinoma, adenocarcinoma and large cell carcinoma of the lung. The tendency of small cell carcinoma to be ectopically active, and to spread very early and widely is among the most typical characteristics (1).
Respiratory Infections in the Elderly
Authors: Michael S. Niederman
Journal: Annals of Internal Medicine (1992)

Part 1 Epidemiology of respiratory infections in the elderly, David Bentley and Joseph M. Mylotte: pneumonia - incidence, demographics defining the patient at risk community-acquired pneumonia nursing home-related pneumonia nosocomial pneumonia and relation to underlying illness tuberculosis - an increasing problem in the elderly airway infections - acute bronchitis in patients with lung disease. Part 2 Pulmonary host defenses in the elderly, Anthony L. Esposito: overview of the normal respiratory host defense system impairments in respiratory host defenses in the elderly - impairments related in aging impairments related to coexisting illness, including malnutrition impairments related to therapeutic interventions and medications. Part 3 Community-acquired pneumonia in the elderly, Michael S. Niederman and Alan M. Fein: general features - presentations, laboratory findings, effect on coexisting illness, relationship of presentation to outcome specific common bacterial and viral infections - pneumococcus, legionella, gram-negative microorganisms, viral pneumonia / influenza. Part 4 The common cold, Ann R. Falsey: incidence clinical features morbidity and complications therapy - antiviral approaches, symptom control. Part 5 Influenza in the elderly, Thomas R. Cate: clinical syndromes, including variations in the elderly complicatons therapy prevention, including control in nursing homes. Part 6 Airway infection, Robert A. Stockley: acute bronchitis - presentation, complications, therapy bronchiectasis - clinical picture, pathogenesis, antibiotic therapy and prophylaxis, diagnostic techniques. Part 7 Newer or emerging pulmonary pathogens for respiratory infection in the elderly, Elizabeth A. Williams and Abraham Verghese: common pathogens in the elderly newer pathogens - why do they emerge in the elderly? clinical settings for the new pathogens. Part 8 Tuberculosis in the elderly, Asim K. Dutt and William W. Stead: clinical features - how tuberculosis differs in the elderly diagnosis and control of tuberculosis in nursing homes therapy and prophylaxis of tuberculosis in the elderly. Part 9 Nosocomial pneumonia in the elderly, Michael S. Niederman: the postoperative patient the intubated patient aspiration pneumonia in the hospital. Part 10 Pharmacology of antimocrobials in the elderly. Part 11 Aspiration pneumonia in the elderly. Part 12 Slowly resolving pneumonia in the elderly. Part 13 Airborne infections in nursing homes. Part 14 Respiratory infections in the elderly. Part contents.
Predictive markers of response to neoadjuvant chemotherapy in locally advanced breast cancer (LAPC)
Authors: A. Mukherjee, M. Shehata, R. Sharma, E. Rakha, I. Ellis, G. Ball, B. M. Ball, S. Chan
Journal: Journal of Clinical Oncology (2008)

581 Background: It is important to identify chemo-resistance to avoid unnecessary treatment. This study aimed to investigate markers for this purpose using tumor biopsy and serum samples before and after chemotherapy in the neoadjuvant setting. Methods: 135 LAPC patients were treated with either 6 cycles of FEC (n=96) or 4 cycles of EC followed by 4 cycles of paclitaxel/paclitaxel-gemcitabine (n=19) or the same regimen in reverse sequence (n=20) between 1996 and 2007. Standard immunohistochemistry (IHC) techniques were employed to assess marker expression in prechemo core biopsies (110) and postchemo surgical samples (90) and results correlated (chi-square) with clinical (RECIST) and pathologic complete response (pCR). Markers included ER, PR, HER2, Topo2α, Ki67, p53, EGFR and the basal phenotype (BP) (cytokeratins CK5/6 and/or CK14 IHC positive in >10% tumor cells). Serum samples of 40 patients pre- and postchemotherapy were studied using MALDI- mass spectrometry for protein profile. Results: For FEC combination, clinical CR and pCR was 34% and 21%, respectively. This is similar to the 60 patients who have adequate tumor samples for analysis by IHC (clinical CR and pCR: 41% and 24%). Clinical CR correlated with pCR in 40% cases; clinical nonCR was false negative in 10%. Prechemotherapy Topo2α +ve (p=0.003), p53 + ve (p=0.04), EGFR -ve (p=0.013) and ER -ve (p=0.04) status correlated with pCR (univariate analysis). On multivariate analysis, only Topo2α (p=0.005) and EGFR (p=0.01) correlated with pCR. Though the BP was highly expressed (56% positive), it did not correlate with either clinical (p=0.7) or pathologic (p=0.34) CR. Excluding the pCR cases (due to resolution of tumor), there were no significant changes in marker expression pre- and postchemotherapy except for p53. Conclusions: The study suggested that high Topo2α and low EGFR correlated with pCR to anthracycline combination. The BP did not predict differences in chemotherapy response. The data from IHC in combination with proteomic analysis may indicate the functional proteome correlating with chemotherapy response. No significant financial relationships to disclose.
B-Cell Lymphoma Unclassified, Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma: A Single Center Experience of Intensive Chemotherapy with and without Auto-SCT
Authors: Anna E. Lukina, Elena A. Baryakh, Alla M. Kovrigina, Eduard G. Gemdzhian, Vsevolod A. Misyurin, Sergey K. Kravchenko, Vladimir I. Vorobyev, Jana K. Mangasarova, Aminat U. Magomedova, Yuri U. Polyakov, Tatiana N. Obukhova, Eugene E. Zvonkov, Anna K. Morozova, Valeri G. Savchenko
Journal: Blood (2014)
Systematic Comparison of Digital Electrocardiograms From Healthy Athletes and Patients With Hypertrophic Cardiomyopathy
Authors: Rachel E. Bent, Matthew T. Wheeler, David Hadley, Joshua W. Knowles, Aleksandra Pavlovic, Gherardo Finocchiaro, Francois Haddad, Heidi Salisbury, Sarah Race, Yael Shmargad, Gordon O. Matheson, Nikhil Kumar, Divya Saini, Victor Froelicher, Euan Ashley, Marco V. Perez
Journal: Journal of the American College of Cardiology (2015)
Proceedings of the British Thoracic Society. 1988 summer meeting. 13-15 July, Newcastle upon Tyne. Abstracts.
Authors: C.E. Bucknall, C. Robertson, F. Moran, R.D. Stevenson
Journal: Thorax (1988)

We have examined the pattern of change in serial peak flow recordings (SPFRs) in 53 patients who subsequently under- went specific bronchial provocation tests with occupational agents as part of the investigation into possible occupational asthma.These patients represented all those in whom both tests were performed out ofa total of41 1 patients seen during a five year period.SPFR data were reviewed by two observers independent of knowledge of the results of subsequent bronchial provocation tests.In 29 patients in whom inhala- tion tests with a specific occupational agent provoked an asthmatic response SPFRs demonstrated work related asthma (WRA) in 10 (34%), asthma without work relation- ship in 17 (59%), and no abnormality in two (7%).In 24 patients in whom specific inhalation tests provoked no asthmatic response SPFRs demonstrated asthma without work relationship in 15 (63%), no abnormality in seven (29%), and WRA in two (8%) in whom occupational asthma was subsequently diagnosed as being caused by an agent other than that tested in the inhalation tests.SPFR data were also examined in a further 15 patients in whom occupational asthma was diagnosed by the combination of a characteristic history and evidence of specific immunological response.SPFRs in these patients demonstrated WRA in four (27%), asthma without work relationships in nine (60%), and no abnormality in two (13%).These findings suggest that where SPFRs show WRA a diagnosis of occupational asthma can be made with confidence.Where they show asthma without clear relationship to work, it is not possible to exclude an occupational cause, and further investigations can be neces- sary.Where SPFRs do not demonstrateany abnormality it is very improbable that the patient has occupational asthma unless the patient is no longer exposed to the inducing cause of asthma.
Abstract 2882: Directed Evolution of Cardiac Specific Adeno-Associated Vector Variants
Authors: Roger J Hajjar, Jiqiu Chen, Yoshiaki Kawase, Scott McPhee, Jade Samulski, R. J Samulski
Journal: Circulation (2008)

Adeno-associated vectors (AAV) have gained popularity in cardiovascular gene transfer because of their distinct characteristics: long-term expression, minimal immune response and strong tropism to cardiac tissue for specific serotypes (such as AAV9). However AAVs have certain limitations: Neutralizing antibodies in 40% of humans for each AAV serotype and non-specificity of the AAV serotypes to various organs. Chimeric viruses composed of capsid proteins of different serotypes, show distinct transduction profiles. To identify hybrid viruses that can selectively transduce cardiomyocytes in vivo, we generated a library of diverse AAV variants, obtained by DNA shuffling, with an enrichment of cardiotropic AAV variants, called biological nanoparticles (BNPs). We selected five BNPs from these experiments: BNP 108, 109, 111, 689, and 693. We then injected these different BNPs using GFP as a marker gene under the control of CMV along with AAV9 into rats (3 in each group and each time point) through their tail vein at a concentration of 1011 vg (viral genomes). We sacrificed the animals at one and four weeks and examined expression in the heart, liver, lung, kidneys, and aorta. We found that at 1 week, BNP 108 and 109 had the best expression in the heart (61±12% of the myocytes with green fluorescence) while BNP 111 and AAV9 had strong cardiac expression at 4 weeks (93±11% and 79±12% of the myocytes with green fluorescence). None of the BNPs showed expression in the liver, lung, kidneys, and aorta, while AAV9 demonstrated widespread expression in all these tissues. Transcoronary injection of BNP111 at a concentration of 1012 vg demonstrated the efficiency of BNP in transducing myocardium of large animals. We also found that all the BNPs are resistant to preexisting neutralizing antibodies against parent serotypes. These results show that directed evolution of AAV variants can yield BNPs that are highly cardiotropic and highly efficient of transducing cardiac tissue without infecting other organs and having resistance to preexisting neutralizing antibodies against parent serotypes. These BNPs may become very useful for clinical applications.
The revised IPSS predicts survival and leukemic evolution of myelodysplastic syndromes significantly better than IPSS and WPSS: validation by the GROM Italian regional database
Authors: MT Voso, S Fenu, R Latagliata, F Buccisano, A Piciocchi, M Aloe Spiriti, M Breccia, M Criscuolo, A Andriani, S Mancini, P Niscola, Naso, C Nobile, A Piccioni, M D'Andrea, A D'Addosio, G Leone, A Venditti
Journal: Journal of Clinical Oncology (2013)
Dental Caries: Mechanism and Present Control Technics as Evaluated at the University of Michigan Workshop
Authors: Kenneth Alexander Easlick
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal