tbuckley/cabot-search huggingface dataset:
Abstract 5464: CD40 Targeted Imaging of Atherosclerotic Plaque Lesions in ApoE−/− Mice
Authors: Michael Grafe, Thore Dietrich, Dietger Stibenz, Jan Klohs, Andreas Wunder, Esther Lutgens, Mat Daemen, Eckart Fleck, Kristof Graf
Journal: Circulation (2008)

Active inflammation has been identified as major criteria for vulnerable atherosclerotic plaques. So far, they are not detectable by conventional diagnostic methods, such as coronary angiography. Therefore, we wanted to investigate whether molecules expressed in inflammatory, unstable plaques, such as CD40 receptor, can be used for molecular imaging and identification of such lesions. Monoclonal antibodies against CD40 were either coupled to cross-linked dextran-coated iron particles (CLIO) for MR imaging, or to the dye Cy5′5 for near-infrared fluorescence (NIRF) imaging. A matched IgG2A isotype antibody was used as negative control. ApoE−/− mice were fed for 4 month with high cholesterol diet and used as a model of atherosclerosis. Histological specimens of aortic tissues showed abundant expression of CD40 in atherosclerotic lesions of these animals. For NIRF imaging, either 25μg or 500μg Cy5′5-CD40 or Cy5′5-IgG2A were injected into the tail vein, and the aorta was imaged 6 and 24 hours after injection. For MR-imaging CLIO-CD40 (25μg/ml protein) or CLIO-IgG2A were injected and MR images were acquired 2 and 6 hours after injection using a 7 T scanner (Bruker). To prove the specificity of this approach NIRF imaging was also performed in double knockout Apo−/− CD40−/− mice High antibody concentrations (500μg Cy5′5-antiCD40) induced high fluorescence in the aortic wall and no difference to Cy5′5-control IgG2A at 6 and at 24 hours was detectable. Low concentrations (25μg) resulted in accumulation of fluorescence in Sudan-positive areas (r2=0.62) whereas low background fluorescence was detected after injection of Cy5′5-IgG2A (p &lt; 0,05, n = 4) and in double knockout Apo−/− CD40−/− mice in the aortic arch. Fluorescence increased slightly after 24 hours compared to 6 hours after injection. Injection of CLIO-anti-CD40 induced a stable signal in the aortic arch in T2 weighted images of ApoE−/− mice compared to control CLIO-IgG2A. Detection of CD40 in atherosclerotic plaques with different imaging modalities is feasible. The approach might serve as a tool for detection of lesions with high inflammatory activity.
Abstract 17131: Mir-204 Downregulation Triggers the Activation of Src/stat3/nfat/bmpr2 Axis in Pulmonary Arterial Hypertension.
Authors: Audrey Courboulin, Roxane Paulin, Nellie J Giguere, Nehme Saksouk, Caroline Lambert, Tanya Perreault, Eric Paquet, Jacques Cote, Martin J Simard, Sebastien Bonnet
Journal: Circulation (2010)
Weight reduction in schizophrenics by molindone
Authors: G Gardos, J O Cole
Journal: American Journal of Psychiatry (1977)

The weight-reducing property of molindone, a recently introduced antipsychotic drug, was tested in 9 hospitalized chronic schizophrenic patients. There was an average weight loss of 7.6 kg after 3 months on molindone; most of the loss occurred during the first month. The mechanism producing this weight loss is uncertain, but a central anorexigenic effect may be an important factor.
Abstract 632: Autonomic Innervation in Atrial Fibrillation - Immunohistochemical Findings
Authors: Thomas Deneke, Huda Chaar, Peter H Grewe, Thomas Lawo, Andrea Tannapfel, Johanna Mundig, Klaus-Michael Mueller, Andreas Mugge
Journal: Circulation (2008)

Atrial fibrillation (AF) has been determined to be a multifactorial disease of the atria. In addition to electrophysiological and structural remodeling during AF changes in cardiac autonomic innerv...
Abstract P290: Low and High Birth Weight in Relationship to BMI and Risk of Obesity as Adult in U.S. Black Women
Authors: Edward A Ruiz-Narvaez, Lauren A Wise, Hanna Gerlovin, Lynn Rosenberg, Julie R Palmer
Journal: Circulation (2013)

Background: Obesity occurs disproportionately among African-American (AA) women. Although a westernized life-style (e.g. low physical activity and high energy diet) is a major contributor to the obesity epidemic, the higher incidence of obesity in AA women is not fully explained by behavioral factors. Growing evidence indicates that events in the perinatal period may have long-term effects on an individual’s metabolism. In particular, extremes of the birth weight distribution may alter programming of the neuroendocrine system. We postulate that both low and high birth weights result in greater weight gain and obesity risk in adulthood.

Methods: We assessed the association of birth weight with adult body mass index (BMI) and risk of obesity (BMI ≥ 30) in the Black Women’s Health Study (BWHS), an ongoing prospective cohort study that began in 1995 (baseline). We used general linear regression models to estimate mean BMI (baseline) across categories of birth weight (very low birth weight (≤1500 g), low birth weight (1500-2499 g), normal birth weight (2500-3999 g; referent), high birth weight (4000+ g)). We also estimated risk ratios (RR) for obesity (baseline) using log-binomial regression models. Models were adjusted for age at baseline, parental education, maternal age at birth, and energy intake at baseline. The present analyses included 24,089 women who reported their birth weights on a self-administered questionnaire in 1997. We validated self-reported birth weight for the subset of BWHS participants from Massachusetts using birth registry data from the Massachusetts Department of Public Health. Pearson correlation coefficient between self-reported birth weight and registry data was 0.88 and there were no significant differences across BMI categories.

Results: At baseline, mean BMI (±SE, standard error) was 28.0 ± 0.03, and about 28% of the participants were obese. Approximately 2.5% had very low birth weight, 24.3% had low birth weight, 65.2% had normal birth weight, and 8.1% had high birth weight. In multivariate analyses, mean BMI was 0.40 units higher among women with very low birth weight relative to women with normal birth weight (95% CI = -0.08, 0.88); mean BMI was 1.07 units higher among women with high birth weight (95% CI = 0.79, 1.35). Women with very low birth weight had 9% higher risk of obesity (RR = 1.09, 95% CI = 0.97, 1.23) relative to women with normal birth weight; women with high birth weight had 22% higher risk of obesity (RR = 1.22, 95% CI = 1.15, 1.30).

Conclusions: Women with very low or high birth weight had higher mean BMI and greater obesity risk as adults compared with women of normal birth weight. Our results suggest that extremes of the birth weight distribution may inversely affect metabolism over the long-term. Further study is needed to assess the extent to which birth weight explains the higher incidence of obesity in black women.
Abstract 19844: Impact of the CRUSADE, ACUITY and TIMI Major Bleeding Definitions on in-Hospital Mortality in Patients with Non-ST Elevation Acute Myocardial Infarction.
Authors: Rosa Maria Agra Bermejo, Emad Abu Assi, Sergio Raposeiras Roubin, Pilar Cabanas Grandio, Jose Maria Garcia Acuna, Carlos Pena Gil, Jose Ramon Gonzalez Juanatey
Journal: Circulation (2010)

Background: Major bleeding is associated with increased mortality in patients with non-ST elevation acute myocardial infarction (NSTEMI). Although several major bleeding definitions exist, the pred...
Abstract 16031: Effects of Nocturnal Hypertension on Arterial Stiffness and Urinary Albumin Excretion in Dipper Hypertensives: Absolute Nocturnal BP Values over and Beyond Dipping Status
Authors: D. Syrseloudis, C. Tsioufis, V. Tzamou, M. Selima, E. Stefanadi, A. Kordalis, I. Kallikazaros, C. Stefanadis
Journal: Circulation (2010)

Introduction: Both blood pressure (BP) non-dipping and nocturnal hypertension have been associated with accelerated target organ damage (TOD) in hypertension. However the combination of a dipping profile of circadian BP variation with increased absolute nocturnal BP values has never been investigated as regards TOD. Hypothesis: We investigated whether nocturnal hypertensive compared to nocturnal normotensive dipper hypertensives exhibit higher values of indices of vascular and kidney damage and whether nighttime, as compared to daytime, BP is a stronger determinant of arterial stiffness and microalbuminuria. Methods: We studied 402 subjects with stage I -II, newly diagnosed essential hypertension. According to two 24h ambulatory BP recordings 127 dipper subjects were selected and subdivided in nighttime hypertensives (NH, n=75) (nighttime BP ≥120/70) and nighttime normotensives (NN, n=52) (nighttime BP <120/70mmHg). All the participants underwent echocardiographic examination, pulse wave velocity (PWV), a...
Abstract 9312: Prediction of Plasma Brain Natriuretic Peptide Levels Using ECG Gated 320 Slice CT in Subjects with Pulmonary Hypertension in Multiple Regression Models
Authors: Akihisa Kataoka, Nobusada Funabashi, Masae Uehara, Toshihiko Sugiura, Nobuhiro Tanabe, Hiroyuki Takaoka, Koichiro Tatsumi, Yoshio Kobayashi
Journal: Circulation (2011)

Purpose: Plasma brain natriuretic peptide (BNP) levels integrates responses of cardiovascular and pulmonary systems. We tied to predict plasma BNP levels in subjects with pulmonary hypertension (PH) using 320 slice CT and right heart catheter (RHC) examinations. Materials and Methods: 19 consecutive PH subjects (13 female, mean 53 yrs, 13 chronic pulmonary arterial thromboembolism and 6 primary PH) underwent retrospective ECG gated 320 slice CT (Aquilion one), and RHC. CT images were reconstructed every 5% from 0-95% of the R-R interval. We quantified right ventricular (RV) end-diastole (ED) (RVEDV) and end-systole (ES) volumes (RVESV), and RV ejection fraction (EF) (RVEF) and left ventricular (LV) end-diastole (ED) (LVEDV) and end-systole (ES) volumes (LVESV), and LV EF (LVEF) by CT, and mean pulmonary artery (PA) pressure (MPAP) and pulmonary vascular resistance (PVR) by RHC. Results: Plasma BNP was 100.9±100.0pg/ml. RVEDV, RVESV, RVEF, LVEDV LVESV and LVEF by CT were 155.9±47.8ml, 88.3±49.7ml, 46.1±14.1%, 101.1±26.8ml, 31.7±9.6ml and 68.4±6.5%, respectively. MPAP and PAR on RHC were 37.9±10.7mmHg, and 570.3±263.4 dyne.sec.cm-5, respectively. Significant positive correlations were seen between plasma BNP levels and RVEDV (0.536, P&lt;0.05), RVESV (0.645, P&lt;0.01) on CT, MPAP (0.582, P&lt;0.01), PVR (0.661, P&lt;0.01) on RHC. Significant negative correlations were seen between plasma BNP levels and RVEF (-0.578, P=0.01), and LVEF (-0.674, P&lt;0.01) on CT. All predictor variables using CT and RHC were analyzed and plasma BNP levels was predicted by multiple regression formula Y=-6.3X1+0.1X2+1.9X3-1.1X4+0.2X5+384 (Y, plasma BNP levels, X1=LVEF on CT, X2= PAR on RHC, X3=age (yrs), X4=RVEF on CT, X5= RVEDV on CT) (R2=0.646, p&lt;0.05). Conclusion: Plasma BNP levels can be predicted by 320 slice CT and RHC. LVEF and RVEF on CT might be negative predictors and PAR, MPAP on RHC and RVEDV and RVESV on CT might be positive predictors for estimating plasma BNP levels in subjects with PH.
Abstract 13368: Angiotensin-Receptor Neprilysin-Inhibitor Reduces Adverse Cardiac Remodeling after Experimental Myocardial Infarction by Direct Effect on Cardiac Hypertrophy and Fibrosis
Authors: Thomas G von Lueder, Bing H Wang, Andrew R Kompa, Randy Webb, Pierre Jordaan, Dan Atar, Henry Krum
Journal: Circulation (2013)

Purpose: Dual-acting angiotensin-receptor neprilysin (NEP) inhibitors (ARNi), a novel drug class blocking both the angiotensin-II (AngII) receptor and breakdown of natriuretic peptides by NEP, may ...
Abstract 15514: Lymphoid but Not Phagocytic Deficiency in G Protein-Coupled Receptor Kinase 2 Decreases Atherosclerotic Plaque Formation in LDLr−/− Mice
Authors: Jeroen J Otten, Saskia C de Jager, Beatriz Bermudez, Ilze Bot, Theo J van Berkel, Annemieke Kavelaars, Cobi J Heijnen, Erik A Biessen
Journal: Circulation (2010)

Background: Migration of leukocytes towards sites of inflammation, such as atherosclerotic lesions, is guided through chemokines, which interact with G protein-coupled receptors (GPCR) on leukocyte...
Results of Low-Dose Human Atrial Natriuretic Peptide Infusion in Nondialysis Patients With Chronic Kidney Disease Undergoing Coronary Artery Bypass Grafting
Authors: Akira Sezai, Mitsumasa Hata, Tetsuya Niino, Isamu Yoshitake, Satoshi Unosawa, Shinji Wakui, Haruka Kimura, Motomi Shiono, Tadateru Takayama, Atsushi Hirayama
Journal: Journal of the American College of Cardiology (2011)
Abstract 3345: Impact of Preoperative Statin Therapy on Postoperative Major Adverse Cardiac Events Following Coronary Artery Bypass Surgery
Authors: Matthias Thielmann, Markus Neuhäuser, Nikolaus Pizanis, Ivan Aleksic, Markus Kamler, Ulf Herold, Jarowit Piotrowski, Parwis Massoudy, Heinz Jakob
Journal: Circulation (2006)

Background–Statin therapy has been clearly shown to reduce the risk of mortality and coronary events in patients with coronary artery disease. Whether these beneficial effects similarly exist in pa...
Lead Poisoning Associated With Intravenous-Methamphetamine Use—Oregon, 1988
Authors: D.B. Chandler, R.L. Norton, K.W. Kauffman, J. Gordon, L.R. Foster
Journal: JAMA (1990)

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Abstract 17044: Myeloid-Related Protein 8/14 Implicated in Atherothrombosis According to Activated Leukocyte
Authors: Masashi Sakuma, Teruo Inoue, Hiroshi Komoda, Yutaka Hikichi, Isao Taguchi, Norihiko Kotooka, Koichi Node
Journal: Circulation (2013)

Objectives: MRP-14 (S100A9) has been identified by platelet transcriptional profiling as an acute myocardial infarction gene. MRP-14, a member of the S100- family of calcium-modulated proteins, also broadly regulates vascular inflammation. Elevated plasma levels of MRP-8/14 (S100A8/A9) heterodimer predict first and recurrent cardiovascular events. However, a role for MRP-8/14 in acute coronary syndromes (ACS) is largely undefined. The aim of this study was to elucidate clinical and biological significance of MRP-8/14 in patients with ACS. Methods and Results: Plasma levels of MRP-8/14 were measured in 21 patients with ACS and 10 patients with stable coronary artery disease (CAD) using peripheral venous blood samples. MRP-8/14 levels was higher in ACS compared to stable CAD (10.7 vs. 6.4 mcg/L, P=0.033). In 38 consecutive ACS patients, coronary artery MRP-8/14 level was measured using thrombectomy catheter aspiration at the site of the culprit lesion. MRP-8/14 concentration was significantly higher in 23 p...
Abstract 1895: ICD And CRT-D Therapy In The Elderly; High Rates Of Use And Little Data
Authors: Andrew Epstein, G N Kay, Vance Plumb, Jeff Shafiroff, Zaffer A Syed
Journal: Circulation (2007)

Introduction: in primary and secondary prevention (PP and SP)randomized controlled trials (RCTs) of implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy (CRT-D)devices, the median age of enrolled patients (pts) was approximately 64 years(yrs). The purpose of this study is to describe: actual prescribing practice of ICD and CRT-D therapy in the elderly, given their under-representation in these studies. Methods: The ACT Registry is a prospective database that includes over 5,000 pts with an ICD or CRT-D implanted for standard indications. They are herein reported stratified by age ≥ 70 and ≥ 80 yrs old, indication (PP vs SP), device type, and then by device type for each indication. Results : Of 4,560 pts with age recorded, 41% (n= 1,867) of those undergoing initial implantation were ≥ 70 yrs, and 12% (n=546) were ≥ 80 yrs old. For those ≥ 70–79 yrs old (n=1,321), 82% had a PP indication. For those ≥ 80 yrs old (n=546), 79.5% had a PP indication. The distribution of’ CRT-D, dual chamber (DC) ICDs and single chamber (SC) ICDs was 33.1%, 40.7%, and 26.2% respectively for pts 70–79 yrs old. For pts ≥ 80 yrs old, a similar distribution was observed: 32.8%, 40.7% and 26.6%, respectively. For PP pts 70–79 yrs old (n=1,083), the distribution of CRT-D, DC, and SC devices was 37.5%, 37.2%, and 25.3%, respectively. For PP pts ≥ 80, yrs (n=434), the distribution of CRT-D, DC, and SC devices was 37.1%, 36.2%, and 26.7%, respectively. Among SP pts 70–79 (n=238), the distribution of CRT-D, DC and SC devices was 13%, 56.7%, and 30.3% respectively. Among SP pts ≥ 80 (n=112), the distribution of CRT-D, DC and SC devices was 16.1%, 58.0% and 25.9% respectively. For PP pts ≥ 80 yrs receiving a CRT-D, 36% had a QRS duration &gt; 120 ms, 41% were NYHA Class III-IV, and 20.4% met both criteria. Conclusions: Although relatively few elderly pts were included in RCTs on which current practice is based, over 40% of new devices are implanted in pts ≥ 70, and over 10% in pts ≥ 80 yrs. Despite a PP ICD indication in 80% of elderly pts, only ~ 25% receive SC devices. Of elderly pts receiving a CRT-D, &lt; 40% have a QRS duration or NYHA Class meeting usual accepted implant criteria. These data indicate that study of device efficacy and selection in the elderly in needed.
Abstract 1570: Cardioprotection With Red Wine Polyphenol [rwp] Is Regulated By Intracellular Redox Changes Through Thioredoxin
Authors: Samarjit Das, Nadeem Khan, Subhendu Mukherjee, Debasis Bagchi, Narasimman Gurusamy, Harold Swartz, Dipak K Das
Journal: Circulation (2007)
Chimeric CLL-1 Antibody Fusion Proteins Containing Granulocyte-Macrophage Colony-Stimulating Factor or Interleukin-2 With Specificity for B-Cell Malignancies Exhibit Enhanced Effector Functions While Retaining Tumor Targeting Properties
Authors: Jason L. Hornick, Leslie A. Khawli, Peisheng Hu, Maureen Lynch, Peter M. Anderson, Alan L. Epstein
Journal: Blood (1997)

Abstract Although monoclonal antibody (MoAb) therapy of the human malignant lymphomas has shown success in clinical trials, its full potential for the treatment of hematologic malignancies has yet to be realized. To expand the clinical potential of a promising human-mouse chimeric antihuman B-cell MoAb (chCLL-1) constructed using the variable domains cloned from the murine Lym-2 (muLym-2) hybridoma, fusion proteins containing granulocyte-macrophage colony-stimulating factor (GM-CSF) (chCLL-1/GM–CSF) or interleukin (IL)-2 (chCLL-1/IL–2) were generated and evaluated for in vitro cytotoxicity and in vivo tumor targeting. The glutamine synthetase gene amplification system was employed for high level expression of the recombinant fusion proteins. Antigenic specificity was confirmed by a competition radioimmunoassay against ARH-77 human myeloma cells. The activity of chCLL-1/GM–CSF was established by a colony formation assay, and the bioactivity of chCLL-1/IL–2 was confirmed by supporting the growth of an IL-2–dependent T-cell line. Antibody-dependent cellular cytotoxicity against ARH-77 target cells demonstrated that both fusion proteins mediate enhanced tumor cell lysis by human mononuclear cells. Finally, biodistribution and imaging studies in nude mice bearing ARH-77 xenografts indicated that the fusion proteins specifically target the tumors. These in vitro and in vivo data suggest that chCLL-1/GM–CSF and chCLL-1/IL–2 have potential as immunotherapeutic reagents for the treatment of B-cell malignancies.
Correction: Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection
Authors: DL Paterson, S Swindells, J Mohr, M Brester, EN Vergis, C Squier, MM Wagener, N Singh
Journal: Annals of Internal Medicine (2002)

Letters5 February 2002Correction: Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV InfectionSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-3-200202050-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In an article on adherence to protease inhibitor therapy and outcomes in HIV infection (1), the General Health Questionnaire score in Table 4 should be 6.8 ± 0.8 for patients with less than 95% adherence, and the P value for this variable should be 0.0014.Reference1. Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, et al . Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000;133:21-30. [PMID: 10877736] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAdherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection David L. Paterson , Susan Swindells , Jeffrey Mohr , Michelle Brester , Emanuel N. Vergis , Cheryl Squier , Marilyn M. Wagener , and Nina Singh Metrics Cited byPotential roles of pharmacists in HIV/AIDS care delivery in Nepal: A qualitative study 5 February 2002Volume 136, Issue 3Page: 253KeywordsHIV infectionsProtease inhibitor therapyQuestionnaires ePublished: 5 February 2002 Issue Published: 5 February 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 17212: T-Cell Compartment Shifts Following Reperfusion After Primary Angioplasty in Patients with Acute Myocardial Infarction
Authors: Jedrzej Hoffmann, Thomas Wiley, Karel Fiser, Ian Dimmick, Rebecca Stewart, Monika Loeher, Hanspeter Pircher, Jolanta Weaver, Bernard Keavney, Carmen Martin-Ruiz, Thomas von Zglinicki, Ioakim Spyridopoulos
Journal: Circulation (2011)

Background: Primary PCI (PPCI) has substantially improved clinical outcomes of patients with acute ST elevation myocardial infarction (STEMI). However, myocardial ischemia-reperfusion (I/R) injury still remains an important clinical problem. CD4+ T-lymphocytes have been shown to promote I/R injury in a mouse model. It is unknown though, whether T-cells play any role in I/R inflammatory response in patients with STEMI. The goal of our study was to identify relevant changes in T-cell subsets in reperfused STEMI by using newly established 13-parameter flow cytometry (FACS) and hierarchical cluster analysis (HCA) of surface expression as a screening tool. Methods and Results: We analysed 30 patients (pts) with STEMI (12-24h after PCI), 24 stable post-STEMI pts and 18 healthy controls (ctrl) (all male, mean age 60 y). Peripheral blood mononuclear cells were stained for T-cell subset markers (CD3, CD4, CD8, CCR7, CD45RA), co-stimulatory molecules (CD27, CD28) and proliferation-associated markers (CD57, KLRG1, PD1). Following FACS data aquisition, HCA and sequential gating were performed using MATLAB software. While total lymphocyte counts did not differ between STEMI pts, stable post-STEMI pts and ctrl, the analysis of T-cell subsets revealed a significant increase in CD45RA-CCR7+ central memory (CM) populations in both CD4 and CD8 T-cells (see table). HCA revealed strong upregulation of the proliferation marker CD57 on CD4 CM T-cells in STEMI pts. Mean telomere length (mTL) in sorted CD4 T-cells was also reduced in STEMI. A pilot time course study showed a rapid decrease in CD4 T-cells by approx. 30% during the first 60 min following PPCI, possible due to invasion of myocardial tissue by T-cells, which might trigger compensatory proliferation of memory cells. Conclusion: Our results identify for the first time expansion of memory T-cells following reperfusion after PPCI in STEMI, which could provide novel insight into the mechanism of myocardial reperfusion injury.