tbuckley/cabot-search huggingface dataset:
Abstract P066: Associations Between Coronary Artery Calcium and HDL Particle Characteristics in MESA Participants with Very-High Levels of HDL Cholesterol (&gt;80mg/dL)
Authors: John Wilkins, Neil Stone, Kiang Liu, Rachel Mackey, Emil DeGoma, Daniel Rader, Greg Burke, Donald M LLoyd-Jones
Journal: Circulation (2013)

Despite the inverse association between HDL-C and CHD risk across HDL-C values of 20-80mg/dL CHD risk persists in people with very-high levels of HDL-C (&gt; 80mg/dL). These risks may be explained by traditional risk factors and by structural and functional polymorphisms in HDL particles in people with HDL-C &gt;80mg/dL. In Multi-Ethnic Study of Atherosclerosis (MESA) participants with HDL-C &gt;80mg/dL we assessed differences in traditional risk factors and NMR-spectroscopy-derived (NMR) HDL particle characteristics between individuals with and without CAC. We included MESA participants with HDL-C values &gt; 80mg/dL (not on niacin, fibrates, or statins), traditional risk factor and CAC data at baseline exam. We examined the associations between HDL-C, NMR data (HDL particle number, particle size, and the concentrations of large, medium and small-HDL particles and in post hoc analysis ratios of particle size concentrations) and baseline CAC &gt; 0 in separate logistic regression models. We included 269 participants in the analysis, 105 had prevalent CAC. Individuals with CAC&gt;0 were older, had higher fasting blood glucose, higher carotid IMT; there were more men, more people taking blood pressure lowering medications, and more with diabetes as well. There were no significant differences in mean values of traditional lipid fractions between groups, however individuals with CAC&gt;0 had a lower concentration of medium-sized HDL particles and a higher ratio of large to medium HDL particle concentration. There were no significant associations between NMR HDL characteristics and CAC&gt; 0 after multivariable adjustment. In post hoc analysis there was a significant adjusted association between the ratio of large to medium sized HDL particle concentration and the presence of CAC&gt;0 (OR [95% CI]: 1.86 [1.15, 3.00]). In conclusion, participants with CAC and very-high HDL-C had a higher burden of traditional risk factors. However, the ratio of particle size concentrations may help differentiate those with HDL&gt;80mg/dL who are at risk for CAC as well.
Abstract 17172: Depressed Heart Rate Variability and Inflammatory Process in Sarcoidosis Patients.
Authors: Elias Gialafos, Gerasimos Siasos, Dimitris Tousoulis, Evangelos Oikonomou, Marina Zaromitidou, Konstantinos Zisimos, Stamatios Kioufis, Elias Peros, Aggeliki Rapti, Athanasios G Papavassiliou, Christodoulos Stefanadis
Journal: Circulation (2010)

Introduction: Sarcoidoisis (Sar) is a multisystemic disease characterized by extensive inflammation and disturbance of autonomic nervous system function. However, the effect of inflammatory process...
Low Dose of Interleukin-2 Therapy Could Prevent Chronic Graft-Versus-Host Disease: A Randomized Study
Authors: Xiangyu Zhao, Xiaosu Zhao, Yutong Wang, Xin Qian, Yingjun Chang, Lanping Xu, Xiaohui Zhang, Chen Yuhong, Yu Wang, Wei Han, Huan Chen, Chenhua Yan, Fengrong Wang, Wang Jingzhi, Yao Chen, Yuqian Sun, Kaiyan Liu, Xiaojun Huang
Journal: Blood (2014)
Abstract 10868: Diffusion Magnetic Cerebral Imaging (dMRI) Pre and 24 Hours Post Ablation of Atrial Fibrillation: Results on Therapeutic Anticoagulation with Coumadin
Authors: Luigi Di Biase, Andrea Natale, Alessandro Blandino, Pasquale Santangeli, Prasant Mohanty, Rong Bai, Martina Pianelli, Javier E. Sanchez, Rodney Horton, Sanghamitra Mohanty, Elisabetta Toso, Agnes Pump, Mauricio Cereceda Brantes, G.Joseph Gallinghouse, Shane Bailey, Marco Scaglione, J. David Burkhardt, Fiorenzo Gaita
Journal: Circulation (2011)

Introduction: Catheter ablation of atrial fibrillation (AF) carries the potential risk of peri-procedural symptomatic and silent ischemic stroke. We sought to determine the prevalence of positive d...
Abstract 12063: Exercise Stress Echocardiography Exposes Reduced Left Ventricular Contractile Reserve and Abnormalities of Biventricular Function in Children with Repaired Tetralogy of Fallot
Authors: Susan L Roche, Lars Grosse-Wortmann, Mark K Friedberg, Anderw N Redington, Derek Stevens, Paul F Kantor
Journal: Circulation (2011)

Introduction: Early hallmarks of ventricular compromise are needed in patients with repaired tetralogy of Fallot (TOF) so that the evolving pathophysiology might be monitored from its earliest stag...
Neutraligands of CXCL12: Anti-inflammatory activity in an allergic model of asthma
Authors: François Daubeuf, Muriel Hachet-Haas, Vincent Gasparik, Patrick Gizzi, François Rohmer, Jacques Haiech, Dominique Bonnet, Marcel Hibert, Jean-Luc Galzi, Nelly Frossard
Journal: European Respiratory Journal (2011)

Introduction:  The chemokine CXCL12 plays an important role in inflammation. Our team identified a small molecule neutralizing CXCL12, belonging to the family of chalcone, named C05. C05 inhibits interaction with its receptors, CXCR4 and CXCR7 (Hachet-Haas et al, JBC 283,23189,2008), and the eosinophil infiltration in a mouse model of allergic eosinophilic airway inflammation. We here evaluated the effect of this neutraligand C05 on airway hyperresponsiveness (AHR), inflammation and airway remodelling.   Methods:  Nine week-old male Balb/c mice were sensitized to ovalbumin (OVA+Alum i.p., D0, D7) and challenged to OVA or solvent i.n. on D18,19,20,21. C05 (350μmol/kg)  vs  vehicle was administered i.p. once daily, 2h before each OVA challenge.   Results:  OVA induced AHR (whole body plethysmography), eosinophilia, increase in IL-4, IL-5 and mucus secretion in bronchoalveolar lavage fluid, increase in lung collagen, as well as increased IgE and IgG1 in plasma. C05 decreased AHR (44±2%), eosinophilia (48±7%), IL-5 (44±8%), mucus (67±10%) in BAL, and lung collagen (100±21%). IgE and IgG1 levels in plasma and IL-4 secretion in BAL were not modified. In addition, C05 did not modify body or spleen weight. Furthermore, C05 did not induce any CXCR4+ cell recruitment in blood as opposed to AMD3100, a CXCR4 antagonist  vs  control group (11±1, 30±3  vs  9±1%).   Conclusion:  The CXCL12 neutraligand therefore appears as a safe and good candidate in this asthma model.
Abstract 16479: Cardiomyocyte Aldose Reductase Expression Increases Cardiac Fibrosis and Heart Dysfunction in the Setting of Reduced Fatty Acid Oxidation
Authors: Ni-Huiping Son, Radha Ananthakrishnan, Shuiqing Yu, Raffay Khan, Qing Li, Ira J Goldberg, Ravichandran Ramasamy
Journal: Circulation (2011)

Introduction: A switch in energy source from fatty acid (FA) oxidation (FAO) towards glucose oxidation has been implicated in cardiac ischemic injury and dysfunction. Recent investigations suggest ...
Abstract 3264: N-cadherin Mediated Mechanosensitivity and Its Role in Myocyte Cytoskeleton Remodeling
Authors: Anant Chopra, Erdem Tabdanov, Gregory P Botta, J. Yasha Kresh, Paul Janmey
Journal: Circulation (2009)

Cell-matrix and cell-cell adhesions are crucial in maintaining the structural integrity and contractile function of cardiac myocytes. Changes or disruptions to these adhesions can have adverse affe...
Unusual Visualization of the Ilium in Lower-Extremity Radionuclide Venography With 99mTc MAA
Authors: Zhanli Fu, Jin Zhang, Qian Li, Meng Liu, Tong Zhou
Journal: Clinical Nuclear Medicine (2015)

A 60-year-old man was admitted with dilated cardiomyopathy, right-sided heart failure, and massive ascites. Tc-labeled macroaggregated albumin radionuclide venography of the lower extremities was performed, which showed stagnated radioactivity in the heart chambers, decreased uptake in the lung, and increased uptake in the proximal main renal veins and hepatic vein. Unexpectedly, radioactive accumulation in the ilium was noted on subsequent images acquired 3 minutes later.
Abstract P092: Relation of Nutrient-rich Diet to Blood Pressure and BMI: The INTERMAP Study
Authors: Ghadeer S Aljuraiban, Queenie Chan, Linda Oude Griep, Jeremiah Stamler, Linda Van Horn, Martha L Daviglus, Lyn M Steffen, Katsuyuki Miura, Liancheng Zhao, Paul Elliott, Gary Frost
Journal: Circulation (2013)

Objective The Nutrient Rich Food (NRF) index serves for measurement of nutrient quality of individual foods and can also be used to assess nutrient density of the overall diet. Unlike other methods...
Abstract 2776: Intravascular Ultrasound Guidance: Angiographic and Procedural Correlates of Stent Thrombosis After Intracoronary Implantation of Drug-Eluting Stents
Authors: Probal Roy, Rebecca Torguson, Ashesh N Buch, Aamir Javaid, Teruo Okabe, Tina L Pinto Slottow, Daniel H Steinberg, Kimberly Smith, Zhenyi Xue, Lowell F Satler, Kenneth M Kent, William O Suddath, Augusto D Pichard, Ron Waksman
Journal: Circulation (2007)
Abstract 17087: Doubled Survival From Out-of-Hospital Cardiac Arrest in a Rural Community in North-Norway Following Implementation of an Aggressive Chest Pain Protocol with Early Prehospital Thrombolysis for STEMI
Authors: Janne M Lien Nilsen, Ida Bø, Jan R Rasmussen, Esten K Haanaes, Mads Gilbert
Journal: Circulation (2011)

Introduction Survival from prehospital cardiac arrest (PCA) remains low. Tromsø municipality in rural North-Norway has a mixed urban-rural population of 60.000, good ground and air ambulance systems, short response times, and dispatch centres staffed with nurses and paramedics, all loyal to current guidelines. Hypothesis By changing focus from the onset of ‘ collapse ’ in PCA to the onset of chest pain in acute coronary syndrome, we hypothesized that more PCA-patients could survive by saving time to alarm, dispatch, diagnosis and first defibrillation. We started an aggressive criteria based prehospital chest pain protocol in 2000. Local GPs and ambulance paramedics were trained in symptoms and signs of STEMI, to access and transmit prehospital 12-leads ECG, give MONA as well as early prehospital thrombolysis (PHT) to patients with prehospital diagnosed acute STEMI. We applied defibrillation pads to all chest pain. The population was informed through media stunts. Methods Retrospective study of survival from PCA during two 5-years periods in Tromsø (1999 -2004; 2004-2009). Each PCA patient's Utstein-chart, digital dispatch centre logs, hospital records and non-survivors autopsy reports were analysed. Results Annual incidence of PCA with resuscitation attempts and ambulance dispatched was 45,3 pr. 100.000. During first 5-years, 10,5 % of all patients (18/172) with PCA were discharged alive. During second period, survival to discharge doubled to 22,3 % (31/139, p&lt;0,05). Presence of an initial shockable rhythm (VF/VT) increased significantly. In patients with witnessed PCA of cardial etiology and a shockable first rhythm, survival to discharge was 21,4 % during the first 5-years period, but doubled to 44,2 % (19/43, p&lt;0,05) in the second period. CPR was started by lay bystanders prior to ambulance arrival in 68,2 % of patients during first, increasing to 76,3 % during the second study period (NS). Prehospital ambulance response time was unchanged at 10 min in each period. By moving system attention ‘to the left of cardiac arrest’, survival to discharge doubled.
Abstract 9050: Drug-Drug Interactions Between Aspirin and NSAIDs are Predicted by Kinetics of Cyclooxygenase-1 Inhibition
Authors: Aaruni Saxena, Holger Gohlke, Supriya Singh, Karsten Schroer, Thomas Hohlfeld
Journal: Circulation (2012)

Background and aims : Therapy with NSAIDs may interfere with antiplatelet activity of aspirin. The mechanism of this drug-drug interaction has not yet been established on the level of enzyme kinetics and quantitative structure-activity relationship (QSAR). Methods: Time-dependent kinetics (log K) for the onset of COX-1 inhibition was measured for 17 common NSAIDs using arachidonic acid-induced COX-1 activity (human platelet microsomes, bioluminescence). IC50 values of all NSAIDs were determined by arachidonic acid-induced platelet thromboxane (TX) formation in platelet rich plasma, as well as the in vitro interaction with aspirin. Dragon and SYSTAT softwares served to develop QSAR models in which dependent parameters were log K and IC50 and independent parameters were structural/physico-chemical parameters (MoR32m, G2v, L3S, representing the shape, size and polarizibility). Results: All NSAIDs could be classified into a time-dependent (slow onset) or a time-independent (fast onset) mode of inhibition. Time-dependent NSAIDs included diclofenac, flurbiprofen, indomethacin, ketoprofen and ketorolac. These NSAIDs did not decrease TX inhibition by aspirin. In contrast, all other studied NSAIDs were time-independent inhibitors and prevented inhibiton by aspirin. The inhibition kinetics (log K) and IC50 were correlated with MoR32m, G2v and L3S (equations 1 and 2). eq.1: -log IC50 = 4.54 (±0.99) MoR32m - 64.62 (±12.58) G2v + 3.41 (±0.56) L3S + 8.59; r = 0.91; r2 = 0.84; s = 0.41; F = 22.81; PRESS = 5.00. eq.2: -log K = 2.35 (±0.69) MoR32m - 16.50 (±8.68) G2v + 1.18 (±0.39) L3S + 1.61; r = 0.74; r2 = 0.55; s = 0.29; F = 5.49, PRESS= 3.01; r, correlation coefficient; s, standard deviation; F, Fisher’s test; PRESS, sum of square differences. Conclusions: NSAIDs decrease the antiplatelet activity of aspirin. This is highly dependent on the inhibition kinetics of platelet COX-1, whereas the inhibition kinetics and IC50 values for TX inhibition further depends on MoR32m, G2v and L3S of a particular NSAID. Time-independent NSAIDs decrease the anti-platelet activity of aspirin. Therefore, time-dependent NSAIDs should be preferred in patients on antiplatelet treatment with aspirin. The QSAR models may predict the kinetics and enzyme inhibition by NSAIDs.
Abstract 5412: Cardiomyocytes Produces Acetylcholine in Response to Muscarinic Receptor Stimulation: A Possible Mechanism for Amplification of Cardioprotective Effects of Cardiac Vagal Nerve
Authors: Yoshihiko Kakinuma, Tsuyoshi Akiyama, Mikihiko Arikawa, Takemi Handa, Takayuki Sato
Journal: Circulation (2008)
Abstract 15467: The Impact of Systolic Blood Pressure on Arterial Stiffness is Exaggerated in Young Prehypertensive Patients
Authors: Joseph Poole, Alanna Morris, Dorothy Coverson, Danny Eapen, Robert Neuman, Gary Gibbons, Rebecca Din-Dzietham, Jose Binongo, Arshed Quyyumi
Journal: Circulation (2011)

Background: Measures of arterial stiffness predict adverse CVD events. Both age and blood pressure (BP) are determinants of arterial stiffness, but their interaction is unknown. We hypothesized tha...
Abstract 4414: DNA Variations in Voltage-gated Calcium Channel Beta 2 Subunit (CACNB2) Gene, Functional Consequences, and Association with Adverse Cardiovascular Outcomes in the INternational VErapamil SR-trandolapril STudy-GENEtic Substudy
Authors: Yuxin Niu, Taimour Y Langaee, Yan Gong, James I Moss, Rhonda M Cooper-Dehoff, Carl J Pepine, Julie A Johnson
Journal: Circulation (2008)

Background: Genetic variations in the CACNB2 gene, which encodes a regulatory subunit of the L-type calcium channel, have not been thoroughly characterized. We undertook a single nucleotide polymorphism (SNP) discovery effort to characterize SNPs in CACNB2 and to determine if these SNPs were associated with adverse cardiovascular outcomes in patients with hypertension and coronary artery disease (CAD), and if associated, to determine functional underpinnings. Methods: Genomic DNA from 60 ethnically diverse individuals was used for SNP discovery. SNPs from exons, intron/exon junctions, 5′ and 3′UTR of CACNB2 were identified and characterized by direct DNA sequencing. Four common SNPs (rs12764271, rs7069292, rs16917273, and rs2357928) from the 14 SNPs that were predicted to be functional by PolyMApr, were selected for a clinical association study in 1032 hypertensive CAD patients in INVEST-GENES who were randomized to atenolol or verapamil-SR-based treatment. Reporter assays were performed in CHO and HEK293...
Abstract 3288: Association of Treatment with Non-Steroidal Anti-Inflammatory Agents (NSAIDS) on Study Entry with 30 Day Adverse Outcomes Among ST Elevation MI (STEMI) Patients Treated with a Fibrinolytic Agent. An EXTRACT-TIMI 25 Analysis
Authors: C Michael Gibson, Sabina A Murphy, Carolyn H McCabe, David A Morrow, Elliott M Antman, Eugene Braunwald
Journal: Circulation (2006)

Background: Many over-the-counter non-aspirin NSAIDs obstruct access to the binding site of aspirin to platelet cyclooxygenase-1 (COX-1), which potentially interferes with aspirin’s cardioprotectiv...
围手术期急性肾损伤：危险因素、识别、治疗及预后
Authors: Emma, Borthwick, Andrew, Ferguson, 林琼真, 杨莉
Journal: BMJ (2010)

急性肾损伤（AKI），既往称为“急性肾衰竭”，与增加合并症和病死率、延长住院时间以及增加医疗费用相关。尽管如此，关于围手术期急性肾损伤，即发生在外科手术入院及出院期间的AKI，已发表的资料基本来自心血管外科，其他外科系统的报道很少。无论临床哪个科室，普遍存在AKI延误诊断的问题，并且很大一部分病例治疗并不恰当。
Abstract 2141: Lead Extraction in Pediatric and Congenital Heart Disease Patients
Authors: Joseph Atallah, Charles I Berul, Mark E Alexander, John K Triedman, Edward P Walsh, Frank Cecchin
Journal: Circulation (2008)

Background: Transvenous pacemaker and defibrillator device implant is a rapidly growing practice in pediatric and young adult congenital heart disease. The need for lead extraction is an associated eventuality in certain patients. Although several techniques have emerged in the past few years, the safety and efficacy of lead extraction in the pediatric population remains unknown. We report our experience with lead extraction using simple traction or complex extraction methods. Methods: Retrospective cohort study of all patients having undergone a lead extraction at Children’s Hospital Boston from 2002 to 2008. Lead extraction was defined as simple if only traction was required and complex if it required the use of an interlocking stylet. Results: A total of 114 patients underwent 124 lead extraction procedures with a total of 172 extraction attempts. The average age was 17.1 (2.47– 48.23) years at lead implant and 23.0 (6 –52.7) years at lead extraction. Congenital heart disease was present in 57.3% (71/124) of patients. Extraction by simple traction was achieved for 51 leads (mean lead age=3.1 years), while the remaining 121 leads required complex extraction (mean lead age=7.5 years), of which 32 were abandoned. Of the remaining leads 83/89 (93%) were extracted successfully. Only 2/55 (4%) leads &gt;7.5 years of age could be extracted with simple traction. However, 63/99 (64%) leads &gt;1 and &lt;7.5 years of age were a complex extraction. Multivariable logistic regression analysis showed that a younger lead age (OR=0.7, 95% CI 0.6 – 0.9, P&lt;0.01), silicone-type of lead insulation (OR=7.6, 95% CI 1.6 –36.7, P=0.01) and a lead in the atrial position (OR=3.0, 95% CI 1.1– 8.7, P=0.05) were independent predictors of a simple extraction. There was only one major complication consisting of right atrial perforation and tamponade that was controlled with surgical exploration. There was no mortality related to lead extraction procedures. Conclusion: The majority of leads implanted in pediatric and young adult patients with congenital heart disease can be extracted successfully. Though certain lead characteristics correlated with a simple extraction procedure, the majority of leads &gt;1 year of age will require a complex extraction technique.
Empathy: misconceptions and misuses in psychotherapy
Authors: H E Book
Journal: American Journal of Psychiatry (1988)

The frequent misconceptions and misuses of empathy that occur during psychotherapy are related to confusion about the definition of empathy, misunderstanding of the difference between the process of empathy and the therapist's response of being empathic, countertransference exploitation of empathy to act out the therapist's needs, the therapist's unawareness of the "layering" phenomenon, and overlooking the patient's level of self-other differentiation. These misuses result in the patient's feeling misunderstood and damaged, with a subsequent weakening of the therapeutic alliance and, at times, a breakdown in self-other differentiation. Once identified, misuses should be addressed and explored in psychotherapy to offset disruptions in treatment.
Abstract 303: Frequency of Newborn Resuscitation and Stabilization in Three Normal-Risk Delivery Units in Norway
Authors: Christiane Skåre, Britt Nakstad, Jo Kramer-Johansen, Silje ødegaard, Thorbjørn Steen, Dana Niles, Anne L Solevåg, Vinay M Nadkarni, Theresa M Olasveengen
Journal: Circulation (2013)

Introduction: Most newborn infants transition from intra- to extrauterine life without interventions; yet neonatal morbidity remains a significant health problem in both resource rich and resource poor health care systems. Although advanced resuscitation of newborn infants with chest compressions, intravenous drugs, and fluids is relatively rare, there are limited data on the frequency of neonatal stabilization and resuscitation measures in normal-risk delivery units. METHODS: Prospective, observational study conducted in the delivery units in three hospitals in Norway. All newborn infants assessed for stabilization and/or resuscitation during one month were included. After each incident, data on resuscitation measures and outcome were registered and reviewed by study personnel at every on-call team shift during the study period. Approval was obtained from department heads and institutional review boards. Results: 1507 babies were live born during the study period, mean weight 3.3 kg and gestational age 39.4 weeks.: 113 (7 %) needed resuscitation interventions beyond drying and stimulation. Suctioning of oropharynx was performed in 77 babies (5 %) and tracheal suctioning in 10 (1%). Positive pressure ventilation (PPV) was provided by a T-piece resuscitator and/or by a self-inflating bag to 58 (4 %) with 39 (3 %) receiving supplementary oxygen. In addition CPAP (but no PPV) was provided to 17 (1 %). One needed chest compressions. Tracheal intubation was accomplished in 4 infants of whom 3 were prematurely born and treated with tracheal surfactant. Intravenous access was established in 8 infants, two received saline infusions and one received epinephrine. After initial resuscitation, 64 (4 %) were admitted to the neonatal intensive care unit and two died. Twenty-one events were handled exclusively by midwifes, 244 by pediatric residents and 39 by attending neonatologists. CONCLUSION: Most newborns do not need advanced resuscitation procedures. However, even in low risk deliveries, more than 4 % of newborns required assisted ventilation. Correct assessment of need for ventilatory support and correct execution of positive pressure ventilation needs to be ensured.