POS1114 PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPARATIVE STUDY BETWEEN TWO LARGE NATIONAL REGISTRIES: SPANISH AND ARGENTINE, FOCUSED ON OUTCOMES DIFFERENCES
Authors: R. Quintana, Í. Rúa-Figueroa, J. Martínez-Barrio, M. A. García, M. Galindo-Izquierdo, L. Garcia, J. Calvo Alén, C. Gobbi, E. Uriarte Isacelaya, P. Alba, E. Tomero Muriel, V. Bellomio, M. Freire González, S. Roverano, V. Martinez Taboada, A. Alvarez, E. Salgado Perez, C. Graff, P. Vela Casasempere, C. Pisoni, A. Fernández-Nebro, A. Spindler, C. Sanguesa, C. Gomez, J. Narváez, H. M. Figueredo, G. Santos Soler, S. Papasidero, J. A. Hernandez Beriain, R. H. Paniego, A. Pecondon, M. C. De la Vega, O. Ibarguengoitia, E. E. Civit, G. Bonilla, L. González Lucero, V. Torrente Segarra, M. V. Martire, A. P. Cacheda, R. Aguila Maldonado, M. J. Garcia-Villanueva, S. A. Gordon Dolimpio, C. Moriano, M. L. Micelli, L. Horcada, R. Nieto, G. Rausch, G. Pons-Estel, N. Lozano Rivas, J. M. Pego-Reigosa
Journal: Annals of the Rheumatic Diseases (2024)

<h3>Background:</h3> Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multi-organ involvement, associated with substantial morbidity and mortality. A characteristic that distinguishes lupus patients is the aggressiveness of the disease, associated with worse outcomes, especially in certain ethnic groups. Patients of Afro-American ethnicity or Hispanics present more frequency of renal disease and higher damage accrual, as compared to Caucasians, and there is certain controversy regarding the factors that explain these differences and the relevance of the socioeconomic status on there. <h3>Objectives:</h3> To compare the clinical and serological features, treatments, outcomes and comorbidities of SLE patients from the cross-sectional phase of the Spanish lupus registry (RELESSER), those Latin American patients residing in Spain, who belong to the RELESSER register and patients from the Argentinian register (RELESSAR). <h3>Methods:</h3> RELESSER and RELESSAR are large multicenter registries and share the same database, with identical definitions of the variables. Likewise, both include patients who meet the ACR/1997 classification criteria. The variables collected were: demographics, clinical, serology, comorbidities and treatments; disease activity index (SELENA-SLEDAI), damage (SLICC/ACR Damage Index (SDI). The Charlson Comorbidity Index was performed as well as Katz score. In RELESSER, Latin American patients were defined as those born in Latin American countries, whose Latin American parents have emigrated to Spain. Other ethnic groups of RELESSER were excluded from this analysis. The categorical variables were compared using Chi-square test or Fisher's test, and for the continuous variables, ANOVA or the Kruskal Wallis test were carried out. In cases where significant differences were found between the groups, and multiple comparisons were performed. The significance level &lt; 0.05 was considered. R software was used for data analysis. <h3>Results:</h3> A total of 5423 patients were included: 1475 in the RELESSAR group, 3627 in the Caucasian RELESSER, and 208 Latin-American from RELESSER. Table 1 shows the multiple comparisons between the groups. Latin-American patients irrespective of the country in which they live have a younger age, shorter duration of the disease with a shorter time to diagnosis, higher severity as measured by Katz Index, more frequency of nephritis, higher SLEDAI and higher use of corticosteroids treatment. However, RELESSER patients had showed higher frequency of comorbidities and hospitalizations. <h3>Conclusion:</h3> Latin-American patients had severe disease, with higher frequency of renal involvement and use of corticosteroids, no matter the country of residence suggesting that health resources would not be a good explanation for these differences. However, Spanish Caucasian patients have more mortality and infection, probably linked to lesser use of antimalarials and high degree of comorbidity. <h3>REFERENCES:</h3> <b>NIL.</b> <h3>Acknowledgements:</h3> <b>NIL.</b> <h3>Disclosure of Interests:</h3> <b>None declared.</b>