tbuckley/cabot-search huggingface dataset:
Nationwide incidence of anterior cruciate ligament reconstruction in higher-level athletes in Sweden: a cohort study from the Swedish National Knee Ligament Registry linked to six sports organisations
Authors: Daniel Castellanos Dolk, Henrik Hedevik, Helena Stigson, Per Wretenberg, Joanna Kvist, Anders Stålman
Journal: British Journal of Sports Medicine (2024)

Objective To determine and compare the incidence rate (IR) of anterior cruciate ligament reconstruction (ACL-R) among higher-level athletes across six sports in the Swedish National Knee Ligament Registry (SNKLR). Methods Patient data from the SNKLR, between 2005 and 2020, was linked to team and event data of six sports (football, handball, basketball, ice hockey, floorball and alpine sports) to identify higher-level athletes aged 15–40 with ACL-R. Unadjusted and adjusted IR ratios (IRRs) with 99% CIs were calculated between sports, sex, age and divisions. Results Female athletes had a 3.3 times higher ACL-R IR compared with males (1.08 vs 0.32, IRR=3.33, 99% CI: 2.65 to 4.19) per 1000 athlete exposures (AE). Basketball had the largest difference in ACL-R IR per 1000 AE between females and males (1.26 vs 0.22, IRR=5.69, 99% CI: 2.79 to 11.60). Female second-division athletes had higher ACL-R IR per 1000 AE compared with female highest-division athletes (1.27 vs 0.76, IRR=1.67, 99% CI: 1.30 to 2.15). No significant association between age and IR was observed. Compared with football, lower ACL-R IR was observed in floorball and ice hockey in females, as well as in floorball, basketball and ice hockey in males. Conclusion Female athletes had higher ACL-R IRs than males and second-division female athletes had higher ACL-R IRs than highest-division female athletes. Lower ACL-R IRs were observed in floorball and ice hockey compared with football for both sexes. The remaining sports had ACL-R IRs similar to football, except basketball where rates were lower for male athletes.
Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression
Authors: Amaia Martinez-Usatorre, Laura Ciarloni, Paolo Angelino, Victoria Wosika, Alessandra Jordano Conforte, Sara S Fonseca Costa, Eric Durandau, Sylvain Monnier-Benoit, Hector Fabio Satizabal, Jérémie Despraz, Andres Perez-Uribe, Mauro Delorenzi, Stephan Morgenthaler, Brian Hashemi, Noushin Hadadi, Sahar Hosseinian-Ehrensberger, Pedro J Romero
Journal: Journal for ImmunoTherapy of Cancer (2024)

Background Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. CRC deaths can be reduced with prevention and early diagnosis. Circulating tumor DNA-based liquid biopsies, are emerging tools for cancer detection. However, the tumor-signal-dependent nature of this approach results in low sensitivity in precancerous and early CRC stages. Here we propose the host immune response to the onset of cancer as an alternative approach for early detection of CRC. Methods We perform whole transcriptome analysis of peripheral blood mononuclear cells (PBMCs) isolated from individuals with CRC, precancerous lesions or negative colonoscopy in two independent cohorts using next-generation sequencing. Results We discover and validate novel early CRC RNA biomarkers. Taking into account, and adjusting for, the sensitivity of PBMCs transcriptomes to processing times, we report distinct transcriptomic changes in the periphery related to specific CRC stages. Activation of innate immunity is already detectable in the peripheral blood of individuals with pre-malignant advanced adenomas. This immune response is followed by signs of transient B-cell activation and sustained inhibition of T-cell responses along CRC progression, whereby at late stages, protumoral myeloid cells, wound healing and coagulation processes prevail. Moreover, some biomarkers show similar dysregulation in tumors and are implicated in known pathways of CRC pathophysiology. Conclusions The strong systemic immune modulation triggered during CRC progression leads to previously unnoticed alterations detectable in PBMCs, paving the way for the development of an early CRC screening blood test, incorporating 226 validated biomarkers identified through immunotranscriptomics.
Antitumor Cream: Transdermal Hydrogel Containing Liposome‐Encapsulated Ruthenium Complex for Infrared‐Controlled Multimodal Synergistic Therapy
Authors: Yu‐Fei Yan, Xue‐Lian Li, Li‐Zhen Zeng, Qishuai Liu, Zhongyan Cai, Yanrong Ren, Xiaoxia Ren, Feng Gao
Journal: Advanced Healthcare Materials (2024)

Abstract A transdermal drug delivery cream, which is non‐invasive and painless, containing a liposome‐encapsulated Ru(II) complex ( LipoRu ) is created for the treatment of skin cancer. This formulation capitalizes on the synergistic antitumor effects of two‐photon excited photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy. LipoRu exhibits effective tumor accumulation, efficient cellular uptake, pH‐sensitive and infrared‐accelerated release, and dual localization to the nucleus and mitochondria. The released Ru(II) complexes within cells exert multiple antitumor mechanisms, such as DNA topoisomerase and RNA polymerase inhibition, Type I and II PDT, PTT, DNA photodamage, and apoptosis and ferroptosis induction. The biodistribution and therapeutic efficacy of LipoRu in vivo are systematically compared via three distinct administration routes: intratumoral injection, intravenous injection, and transdermal delivery through topical cream application. The positive therapeutic effects of the LipoRu cream fabricated here in subcutaneous tumor‐bearing mice offer optimistic potential for the painless and non‐invasive treatment of both early‐stage and advanced skin cancers, as well as superficially located solid tumors.
Ultrasound‐Responsive Carbon Monoxide Microneedle for Enhanced Healing of Infected Diabetic Wounds
Authors: Lei Cao, Chuang Liu, Chuan Mu, Qingqing Li, Min Wu, Luntao Liu, Bin Liu
Journal: Advanced Healthcare Materials (2024)

Abstract Efficient management of difficult‐to‐heal diabetic wounds remains a clinical challenge owing to bacterial infections, as well as oxidative and hyperglycemic complex pathology. Therefore, developing intelligent strategies for diabetic wound healing is urgently needed. Herein, an ultrasound (US)‐responsive microneedle (MN) patch ( MN@GOX@TiO 2‐X @CO ) capable of controlled delivery of carbon monoxide (CO) gas within the skin for effective treatment of diabetic infected wounds is developed. Benefiting from the specific form of microneedle (MN) patch, sonosensitizer (TiO 2‐X ), •OH‐responsive CO prodrug (MPA‐CO), and glucose oxidase (GOX) can be loaded together and effectively delivered to infectious wounds. With the semi‐fluidic hyaluronic acid (HA) coating under the physiological condition, CO could be released efficiently in situ and directly acted on infected wound tissue upon US triggering. Both in vitro and in vivo results showed that US‐triggered CO release from MN@GOX@TiO 2‐X @CO not only effectively inhibited the S. aureus and MRSA infection but also promoted fibroblasts proliferation and migration under hyperglycemic physiology, thereby accelerating diabetic wound healing. Collectively, the approach effectively addresses the impaired skin regeneration function in diabetic wounds and offers a promising therapeutic strategy for the efficient healing of infected diabetic wounds.
Hybrid Cell Membrane‐Coated Nanoparticles for Synergizing Sonodynamic Therapy and Immunotherapy against Triple‐Negative Breast Cancer
Authors: Jiali Gong, Danling Cheng, Changcun Liu, Shan Wu, Na Sun, Lingzhou Zhao, Jingchao Li, Yan Xing, Jinhua Zhao
Journal: Advanced Healthcare Materials (2024)

Tumor immunotherapy represents a highly promising modality for the treatment of triple-negative breast cancer (TNBC). Nevertheless, its therapeutic efficacy has been profoundly impacted by challenges such as low drug uptake, hypoxia, and immunosuppression. To address these problems, the study develops a strategy combining sonodynamic therapy (SDT) and immunotherapy using biomimetic nanoparticles coated with hybrid membranes. The nanoparticles are loaded with semiconducting polymers (PFODBT), Atovaquone (ATO), and TMP195 to enhance biocompatibility, targeting ability, and drug uptake and retention at the tumor site. In in vitro experiments, the biomimetic nanoparticles alleviate hypoxia, induce immunogenic cell death (ICD), and prompt reprogramming of tumor-associated macrophages (TAMs) from M2 type to M1 type. In in vivo experiments, the synergistic effects of enhanced SDT-mediated ICD and TAMs repolarization significantly inhibit the proliferation of primary and distant tumor in the 4T1 subcutaneous tumor model, and effectively attenuated metastasis of lung and liver. Moreover, the in vivo immune responses are further activated by improving the maturation of dendritic cells, filtration of CD8
Near‐Infrared Bioimaging Using Two‐photon Fluorescent Probes
Authors: None Pragti, Bidyut Kumar Kundu, Rui Chen, Jiajie Diao, Yujie Sun
Journal: Advanced Healthcare Materials (2024)

Abstract Near‐infrared (NIR) bioimaging has emerged as a transformative technology in biomedical research. Among many fluorescent probes that are suitable for NIR imaging studies, two‐photon absorption (TPA) ones represent a particularly promising category, because TPA fluorescent probes can overcome the inherent limitations of one‐photon absorption (OPA) counterparts. By leveraging the unique properties of two‐photon absorption, TPA fluorescent probes achieve superior tissue penetration, significantly reduced photodamage, and enhanced spatial resolution. This perspective article delves into the fundamental principles, design strategies, and representative TPA probes for various imaging applications. In particular, a number of molecular fluorescent probes, ranging from organic, inorganic, and COF/MOF‐based systems are highlighted to showcase the vast scope of possible TPA probe design and application scenarios. In addition, the employment of stimulated TPA probes that are responsive to different external factors, including pH, redox species, enzymes, and hypoxia, is also discussed. In the end, the future perspectives for the continuous advancement of TPA fluorescent probes in the NIR bioimaging field are presented. For instance, it is essential to transition from cellular to in vivo imaging studies to obtain more physiologically relevant insights. Additionally, the development of “dual‐function” TPA probes for both disease diagnosis and therapeutic treatment is particularly promising.
Human milk oligosaccharides combine with <i>Bifidobacterium longum</i> to form the “golden shield” of the infant intestine: metabolic strategies, health effects, and mechanisms of action
Authors: Shuo Yang, Junwu Cai, Qian Su, Qiaohui Li, Xiangchen Meng
Journal: Gut Microbes (2024)

Human milk oligosaccharides (HMOs) are the third most important nutrient in human milk and are the gold standard for infant nutrition. Due to the lack of an enzyme system capable of utilizing HMOs in the infant intestine, HMOs cannot be directly utilized. Instead, they function as natural prebiotics, participating in the establishment of the intestinal microbiota as a "bifidus factor." A crucial colonizer of the early intestine is
Butyrate reduces epithelial barrier dysfunction induced by the foodborne mycotoxin deoxynivalenol in cell monolayers derived from pig jejunum organoids
Authors: Julie Alberge, Eloïse Mussard, Carine Al-Ayoubi, Corinne Lencina, Christelle Marrauld, Laurent Cauquil, Caroline S. Achard, Ivan Mateos, Imourana Alassane-Kpembi, Isabelle P. Oswald, Laura Soler, Sylvie Combes, Martin Beaumont
Journal: Gut Microbes (2024)

The foodborne mycotoxin deoxynivalenol (DON) produced by
When I use a word . . . Academic fraud—plagiarism
Authors: Jeffrey K Aronson
Journal: BMJ (2024)

Of the various types of academic misdemeanours and felonies, perhaps plagiarism is the most difficult and complex to study and write about. Even defining it is difficult. The US Office of Research Integrity (ORI) defines plagiarism as "the appropriation of another person9s ideas, processes, results, or words without giving appropriate credit," but how do you define when it has occurred? What are the quantitative and qualitative thresholds? What are the different types of plagiarism? Why does plagiarism occur? How does one detect it? What is self-plagiarism and should we even call it that? There is an enormous literature on the subject and it needs to be tamed; an annotated bibliography would help, if anyone would create one. Perhaps they already have?
Prothrombotic Antibodies Targeting the Spike Protein's Receptor-Binding Domain in Severe COVID-19
Authors: Wen Zhu, Yongwei Zheng, Mei Yu, Nathan Witman, Lu Zhou, Jianhui Wei, Yongguang Zhang, Paytsar Topchyan, Christine Nguyen, Rae Janecke, Anand Padmanabhan, Lisa Baumann Kreuziger, Gilbert C White, Parameswaran Hari, Tongjun Gu, Alexander Thompson Fields, Lucy Kornblith, Richard H Aster, Jieqing Zhu, Weiguo Cui, Shawn M Jobe, Mary Beth Graham, Demin Wang, David Wang, Renren Wen
Journal: Blood (2024)
Covid inquiry: Hancock claims NHS was “hours” from running out of PPE
Authors: Jacqui Wise, Matthew Limb, Gareth Iacobucci
Journal: BMJ (2024)

The inquiry has heard further testimony from former ministers on the effect of the pandemic on UK healthcare systems. <b>Jacqui Wise</b>, <b>Matthew Limb</b>, and <b>Gareth Iacobucci</b> summarise some of the key findings in the latest evidence
A DNA methylation database of human and mouse hematological malignancy cell lines
Authors: Aleix Noguera-Castells, Carlos A. García-Prieto, Gerardo Ferrer, Veronica Davalos, Fernando Setien, Eulàlia Genescà, Jordi Ribera, Josep M. Ribera, Manel Esteller
Journal: Leukemia (2024)
Itacitinib for Prevention of Graft-Versus-Host Disease and Cytokine Release Syndrome in Haploidentical Transplantation
Authors: Ramzi Abboud, Mark A. Schroeder, Michael P Rettig, Reyka G Jayasinghe, Feng Gao, Jeremy Eisele, Leah Gehrs, Julie K. Ritchey, Jaebok Choi, Camille N Abboud, Iskra Pusic, Meagan A Jacoby, Peter Westervelt, Matthew Christopher, Amanda F. Cashen, Armin Ghobadi, Keith Stockerl-Goldstein, Geoffrey L Uy, John F. DiPersio
Journal: Blood (2024)
Beyond static measurements: dynamic frailty improves survival prediction in multiple myeloma
Authors: F. Smits, Kaz Groen, Mark-David Levin, Claudia Stege, Roel J.W. van Kampen, Ellen van der Spek, Yavuz M. Bilgin, Noortje Thielen, Inger S. Nijhof, Inge Ludwig, Esther G.M. de Waal, Yorick Sandberg, Alain Kentos, Gert-Jan Timmers, Josien C. Regelink, Matthijs Westerman, Koen de Heer, Marie-Christiane MB Vekemans, Nazik Durdu-Rayman, Nicole C.H.P. de Graauw, Maarten R. Seefat, Niels W.C.J. van de Donk, Paula F Ypma, Kazem Nasserinejad, Sonja Zweegman
Journal: Blood (2024)
Low dose computed tomography for lung cancer screening in Tuberculosis endemic countries: A Systematic Review and Meta-analysis
Authors: Vikram Damaraju, Juhu Kiran Krushna Karri, Gayathri Gandrakota, Yamini Marimuthu, Adimulam Ganga Ravindra, Rajeev Aravindakshan, Navneet Singh
Journal: Journal of Thoracic Oncology (2024)
Identification of defined molecular subgroups based on immunohistochemical analyses and potential therapeutic vulnerabilities of pulmonary carcinoids
Authors: D J G Leunissen, L Moonen, J H von der Thüsen, M A den Bakker, L M Hillen, T J J van Weert, A Zur Hausen, T P P van den Bosch, L M V Lap, R A Damhuis, N L Reynaert, Esther C van den Broek, L Fernandez-Cuesta, M Foll, N Alcala, A Sexton Oates, A-M C Dingemans, E J M Speel, J L Derks
Journal: Journal of Thoracic Oncology (2024)
Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status-a brief report
Authors: Batel Blechter, Chao Agnes Hsiung, Xiaoyu Wang, Haoyu Zhang, Wei Jie Seow, Jianxin Shi, Nilanjan Chatterjee, Hee Nam Kim, Maria Pik Wong, Yun-Chul Hong, Jason Y Y Wong, Juncheng Dai, H Dean Hosgood, Zhaoming Wang, I-Shou Chang, Jiyeon Choi, Jiucun Wang, Minsun Song, Wei Hu, Wei Zheng, Jin Hee Kim, Baosen Zhou, Demetrius Albanes, Min-Ho Shin, Lap Ping Chung, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young Tae Kim, Xiao-Ou Shu, Young-Chul Kim, Roel C H Vermeulen, Bryan A Bassig, Jiang Chang, James Chung Man Ho, Bu-Tian Ji, Michiaki Kubo, Yataro Daigo, Yukihide Momozawa, Yoichiro Kamatani, Takayuki Honda, Hideo Kunitoh, Shun-Ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Masahiro Tsuboi, Koichi Goto, Zhihua Yin, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Kimihiro Shimizu, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Wu-Chou Su, Yuh-Min Chen, Gee-Chen Chang, Kuan-Yu Chen, Ming-Shyan Huang, Hsien-Chih Lin, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Chien-Jen Chen, Yu-Tang Gao, Chen Wu, Biyun Qian, Daru Lu, Jianjun Liu, Hyo-Sung Jeon, Chin-Fu Hsiao, Jae Sook Sung, Ying-Huang Tsai, Yoo Jin Jung, Huan Guo, Zhibin Hu, Tzu-Yu Chen, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Sonja I Berndt, Wei Wu, Junwen Wang, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Chung-Hsing Chen, Jun Xu, Peng Guan, Wen Tan, Chih-Liang Wang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, Qiuyin Cai, In Kyu Park, Ping Xu, Qincheng He, Chih-Yi Chen, Junjie Wu, Wei-Yen Lim, Kun-Chieh Chen, John K C Chan, Jihua Li, Hongyan Chen, Chong-Jen Yu, Li Jin, Joseph F Fraumeni, Jie Liu, Maria Teresa Landi, Taiki Yamaji, Yang Yang, Belynda Hicks, Kathleen Wyatt, Shengchao A Li, Hongxia Ma, Bao Song, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Li-Hsin Chien, Fang-Yu Tsai, Jinming Yu, Victoria L Stevens, Pan-Chyr Yang, Dongxin Lin, Kexin Chen, Yi-Long Wu, Keitaro Matsuo, Nathaniel Rothman, Kouya Shiraishi, Hongbing Shen, Stephen J Chanock, Takashi Kohno, Qing Lan
Journal: Journal of Thoracic Oncology (2024)
Brief Report: Final overall survival and long-term safety of lorlatinib in patients with ALK-positive non-small cell lung cancer from the pivotal phase 2 study
Authors: Sai-Hong Ignatius Ou, Benjamin J Solomon, Benjamin Besse, Alessandra Bearz, Chia-Chi Lin, Rita Chiari, D Ross Camidge, Jessica J Lin, Antonello Abbattista, Francesca Toffalorio, Ross A Soo
Journal: Journal of Thoracic Oncology (2024)
Minimally invasive versus open surgery for non-functioning pancreatic neuroendocrine tumors: a systematic review and meta-analysis
Authors: Kongyuan Wei, Qingyong Zheng, Luying Cheng, Wei li, Anna Nießen, Faik G. Uzunoglu, Felix Nickel, Jinhui Tian, Zheng Wang, Thilo Hackert
Journal: International Journal of Surgery (2024)

Introduction: Nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) have been diagnosed increasingly often but still represent rare pancreatic neoplasms. Surgery is a potentially curative approach for patients with NF-PNETs. In recent years, minimally invasive surgery (MIS) has been applied more frequently for surgical resection of NF-PNETs. The evidence for using MIS for NF-PNETs is still being determined and controversial. Materials and Methods: PubMed, Cochrane Library, and the Web of Science database were searched systematically from its inception to July 2023. All studies comparing MIS versus open surgery (OPS) of NF-PNETs were included. The primary outcomes were the incidence of overall postoperative complications and pancreas-specific complications [postoperative pancreatic fistula (POPF) and delayed gastric emptying (DGE)]. The secondary measures were duration of operation, intraoperative blood loss, and length of postoperative hospital stay. Pooled results are presented as odds ratios (OR) or mean difference (MD) with a 95% CI. Results: Five observational studies with a total of 1178 patients were included in the final analysis. The meta-analysis indicated that MIS attained less intraoperative blood loss (MD=−58.59, 95% CI [−92.76 to −24.41], P &lt;0.01) and shorter length of hospital stay (MD=−3.07, 95% CI [−5.28 to −0.87], P &lt;0.01) in contrast to open surgery for NF-PNETs. There were no significant differences concerning operative time (MD=52.04, 95% CI [−8.74 to 112.81], P =0.67), overall postoperative complications (OR=0.78, 95% CI [0.59–1.03], P =0.08), POPF (OR=0.99, 95% CI [0.66–1.47], P =0.94), and DGE (OR=0.58, 95% CI [0.58–1.42], P =0.67). Conclusions: This study demonstrates that minimally invasive surgery for NF-PNETs is safe and associated with a considerably shorter postoperative hospital stay. Further studies are needed to verify the evidence.
Dynamic gene expression pattern in zebrafish gall bladder - an experimental study
Authors: Pranay Tanwar, Debashruti Bhattacharya, Abhilash Dasari, Manthan Bijwe, Rashmi Rana, Ishaan Gupta, Shilpi Minocha
Journal: International Journal of Surgery (2024)

Gall bladder cancer (GBC) is one of the common biliary tract malignancies that is often associated with late presentation of clinical symptoms resulting in poor prognosis, thereby considerably increasing the mortality rate. Geographic and ethnic variations are one of the major causes of GBC incidence. However, in addition to genetic susceptibility to GBC, other factors like age, obesity, gender, and exposure to certain heavy chemicals may also lead to the incidence of GBC. Most of GBC research has so far used traditional cell culture systems. Recently, newer approaches using 2D and 3D cultures, xenograft models, and organoids are also becoming popular. However, whole organism model systems for GBC research have not yet been established. In this study, we propose the use of zebrafish as a model organism to study GBC. However, the zebrafish gall bladder is relatively unexplored besides the anatomical features. Here, we unravel and then compare the unique transcriptomic profile of zebrafish gall bladder with humans to identify genes consistently expressed in both species. We provide a comprehensive list of all gall bladder specific genes in zebrafish that also have their orthologous counterparts in humans. Therefore, they can be used as potential biomarkers for gall bladder transcriptomic profile. To the best of our knowledge, this is the only study so far to provide a complete genomic expression profile of zebrafish gall bladder along with an exhaustive cross-species comparison, thus paving the path for using zebrafish as a model organism to study GBC and help identify novel biomarkers for its early detection and diagnosis.