tbuckley/cabot-search huggingface dataset:
Response Assessment in Neuro-Oncology (RANO) 2009-2025: Broad Scope and Implementation - A Progress Report
Authors: Martin J van den Bent, Michael A Vogelbaum, Tim Cloughesy, Norbert Galldiks, Nathalie L Albert, Joerg-Christian Tonn, Edward Avila, Jason Fangusaro, David Mirsky, Arjun Sahgal, Ricardo Soffietti, Philipp Karschnia, Minesh Mehta, Michelle M Kim, Florien Boele, Jason T Huse, Lakshmi Nayak, Mary Jane Lim-Fat, Emilie le Rhun, Annick Desjardins, Eudocia Q Lee, Ugonma Chukwueke, Johan A F Koekkoek, Tito Mendoza, Ashlee R Loughan, Joshua A Budhu, Spyridon Bakas, Raymond Y Huang, Javier E Villanueva-Meyer, Jose Pablo Leone, Hideho Okada, David A Reardon, Wenya L Bi, Patrick Y Wen, Susan M Chang
Journal: Neuro-Oncology (2025)

Abstract Since its first activities in 2008 and 2009, the Response Assessment in NeuroOncology (RANO) group has given guidance on response assessment, trial design and trial procedures in order to improve and standardize the way clinical trials in neurooncological studies are performed. To achieve its objectives, a variety of working groups have been initiated that cover many aspects of clinical trial design and outcome assessment in patients with tumors affecting the Central Nervous System. The RANO working groups are built on expertise without a formal structure, which makes rapid responses to new developments possible. RANO is aiming at evidence based guidelines and recommendations, but in the absence of evidence will provide consensus based guidance achieved by inviting recognized international experts. In its 15 year of existence, more than 60 RANO papers have been published mostly in high ranking journals, and its recommendations have been accepted by regulators and industry as guiding principes. RANO organizes two meetings per year, one in conjunction with the annual American Society for Clinical Oncology (ASCO) meeting, and one during the annual Society for Neuro-Oncology meeting. These meetings are open, as are the working groups of RANO. New initiatives are welcomed.
A choice based conjoint analysis of mobile healthcare application preferences among physicians, patients, and individuals
Authors: Junbok Lee, Jung Hyun Kim, Mingee Choi, Jaeyong Shin
Journal: npj Digital Medicine (2025)

The rapid proliferation of healthcare service applications (apps) makes it challenging for consumers to determine the best one for their needs, prompting the Korean government to introduce an accreditation program to verify app safety. This study aims to identify the factors influencing the choice of healthcare service apps among physicians, patients with chronic diseases, and healthy individuals. We conducted a choice-based conjoint analysis with six factors (number of studies on effectiveness, frequency of information delivery, cybersecurity and data safety, user satisfaction, accreditation, and costs). 1,093 participants (407 healthy individuals, 589 patients, and 97 physicians) participated in the online survey. Across all groups, cybersecurity and data safety were the most important preference factors (healthy individuals: β = 2.127, 95% CI 2.096-2.338, patients: β = 1.569, 95% CI 1.481-1.658, physicians: β = 1.111, 95% CI 0.908-1.314). All groups were willing to pay more approximately $12 for high cybersecurity and data safety compared to low.
Multifunctional Fluorescent Probes for Profiling Cys, Hcy, GSH, and SO₂: Illuminating Their Dynamics in Apoptosis and Ferroptosis
Authors: Guoxing Yin, Ting Yu, Chunhua Lian, Yang Li, Dian Liu, Haitao Li, Huijun Zhou, Peng Yin, Shouzhuo Yao
Journal: Advanced Healthcare Materials (2025)

Abstract The ability to perform simultaneous fluorescence imaging of multiple targets is essential, providing crucial multi‐parametric information necessary for understanding complex biological interactions and processes. In this study, TBC , a novel multi‐signal fluorescent probe is presented, crafted for simultaneous differentiation and in situ real‐time monitoring of homocysteine (Hcy), cysteine (Cys), sulfur dioxide (SO 2 ), and glutathione (GSH), illuminating the dynamic metabolic status of endogenous reactive sulfur species. TBC achieves an ultrahigh signal‐to‐background ratio, enabling wash‐free direct fluorescence imaging of the dynamics and distribution of these entities in living cells and zebrafish. Notably, TBC has revealed distinctive dynamic metabolic features of Hcy/Cys/SO 2 /GSH during apoptosis and ferroptosis. This innovative probe acts as a key tool for unraveling the conversion networks of multiple reactive sulfur species and assessing the impact of metabolic oscillations during programmed cell death and the progression of diverse diseases, effectively uncovering concurrent biochemical dynamics in various biological settings and cell death events.
Biohybrid Vascular Graft Made of Textile‐Reinforced Elastin‐Like Recombinamers and Its Preservation via Drying Processes
Authors: Dominic Pascal Andre, Stephan Ruetten, José Carlos Rodríguez‐Cabello, Stefan Jockenhoevel, Thomas Schmitz‐Rode, Alicia Fernández‐Colino
Journal: Advanced Healthcare Materials (2025)

Abstract Vascular grafts are crucial for treating cardiovascular diseases and providing vascular access for hemodialysis in end‐stage renal disease, conditions that affect millions of people globally. To address the persisting clinical need for better therapy for these conditions, new designs involving novel materials and innovative tissue‐engineered approaches are being developed. Successful clinical translation of such designs will require to ensure device safety, particularly sterility and mechanical integrity. The prevailing method for ensuring sterility is ethylene oxide sterilization, which requires a dry product. The challenge of drying biohybrid implants is substantial, as they contain multiple components (e.g., textile and hydrogel) with differing properties. To address this open question, the effects of different drying methods on the morphological and mechanical properties of biohybrid implants made from elastin‐like recombinamers (ELRs) are investigated. For that, mechanical characteristics defined in ISO 7198, as well as the cell attachment behavior on biohybrid vascular grafts, treated either with lyophilization (LYO) or CO 2 ‐based critical point drying, are compared. The results show that the applied drying method can significantly influence the properties of the scaffolds and highlight the importance of developing implant‐specific drying schemes that ensure its safety and functionality.
Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
Authors: Xiaojie Zhao, Yan Li, Siwei Zhang, Ari Sudwarts, Hanwen Zhang, Alena Kozlova, Matthew J Moulton, Lindsey D Goodman, Zhiping P Pang, Alan R Sanders, Hugo J Bellen, Gopal Thinakaran, Jubao Duan
Journal: Molecular Neurodegeneration (2025)

Abstract Background Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified a plethora of risk loci. However, the disease variants/genes and the underlying mechanisms have not been extensively studied. Methods Bulk ATAC-seq was performed in induced pluripotent stem cells (iPSCs) differentiated various brain cell types to identify allele-specific open chromatin (ASoC) SNPs. CRISPR-Cas9 editing generated isogenic pairs, which were then differentiated into glutamatergic neurons (iGlut). Transcriptomic analysis and functional studies of iGlut co-cultured with mouse astrocytes assessed neuronal excitability and lipid droplet formation. Results We identified a putative causal SNP of CLU that impacted neuronal chromatin accessibility to transcription-factor(s), with the AD protective allele upregulating neuronal CLU and promoting neuron excitability. And, neuronal CLU facilitated neuron-to-glia lipid transfer and astrocytic lipid droplet formation coupled with reactive oxygen species (ROS) accumulation. These changes caused astrocytes to uptake less glutamate thereby altering neuron excitability. Conclusions For a strong AD-associated locus near Clusterin ( CLU ), we connected an AD protective allele to a role of neuronal CLU in promoting neuron excitability through lipid-mediated neuron-glia communication. Our study provides insights into how CLU confers resilience to AD through neuron-glia interactions.
Multimodal GPT model for assisting thyroid nodule diagnosis and management
Authors: Jincao Yao, Yunpeng Wang, Zhikai Lei, Kai Wang, Na Feng, Fajin Dong, Jianhua Zhou, Xiaoxian Li, Xiang Hao, Jiafei Shen, Shanshan Zhao, Yuan Gao, Vicky Wang, Di Ou, Wei Li, Yidan Lu, Liyu Chen, Chen Yang, Liping Wang, Bojian Feng, Yahan Zhou, Chen Chen, Yuqi Yan, Zhengping Wang, Rongrong Ru, Yaqing Chen, Yanming Zhang, Ping Liang, Dong Xu
Journal: npj Digital Medicine (2025)

Although using artificial intelligence (AI) to analyze ultrasound images is a promising approach to assessing thyroid nodule risks, traditional AI models lack transparency and interpretability. We developed a multimodal generative pre-trained transformer for thyroid nodules (ThyGPT), aiming to provide a transparent and interpretable AI copilot model for thyroid nodule risk assessment and management. Ultrasound data from 59,406 patients across nine hospitals were retrospectively collected to train and test the model. After training, ThyGPT was found to assist in reducing biopsy rates by more than 40% without increasing missed diagnoses. In addition, it detects errors in ultrasound reports 1,610 times faster than humans. With the assistance of ThyGPT, the area under the curve for radiologists in assessing thyroid nodule risks improved from 0.805 to 0.908 (p < 0.001). As an AI-generated content-enhanced computer-aided diagnosis (AIGC-CAD) model, ThyGPT has the potential to revolutionize how radiologists use such tools.
XCAT 3.0: A Comprehensive Library of Personalized Digital Twins Derived from CT scans
Authors: Lavsen Dahal, Mobina Ghojoghnejad, Liesbeth Vancoillie, Dhrubajyoti Ghosh, Yubraj Bhandari, David Kim, Fong Chi Ho, Fakrul Islam Tushar, Sheng Luo, Kyle J Lafata, Ehsan Abadi, Ehsan Samei, Joseph Y Lo, W Paul Segars
Journal: Medical Image Analysis (2025)
Mitigating the risk of health inequity exacerbated by large language models
Authors: Yuelyu Ji, Wenhe Ma, Sonish Sivarajkumar, Hang Zhang, Eugene M Sadhu, Zhuochun Li, Xizhi Wu, Shyam Visweswaran, Yanshan Wang
Journal: npj Digital Medicine (2025)

Recent advancements in large language models (LLMs) have demonstrated their potential in numerous medical applications, particularly in automating clinical trial matching for translational research and enhancing medical question-answering for clinical decision support. However, our study shows that incorporating non-decisive socio-demographic factors, such as race, sex, income level, LGBT+ status, homelessness, illiteracy, disability, and unemployment, into the input of LLMs can lead to incorrect and harmful outputs. These discrepancies could worsen existing health disparities if LLMs are broadly implemented in healthcare. To address this issue, we introduce EquityGuard, a novel framework designed to detect and mitigate the risk of health inequities in LLM-based medical applications. Our evaluation demonstrates its effectiveness in promoting equitable outcomes across diverse populations.
A cross-sectional observational study of patients with sicca with salivary autoantibodies defines a potential new phenotype of Sjögren’s disease
Authors: Martha Tsaliki, Joshua Cavett, Biji T Kurien, Christina Bruxvoort, Valerie M Lewis, John A Ice, Devavrat Dave, Sina Khosravani, Kiely Grundahl, Christopher J Lessard, Astrid Rasmussen, Kathy L Sivils, Amy Darise Farris, Kristi A Koelsch, Robert Hal Scofield
Journal: Annals of the Rheumatic Diseases (2025)

Diagnosis of Sjögren's disease (SjD) consists of clinical examinations that include invasive studies such as lower lip biopsies and blood collection to identify presence of serum autoantibodies. Salivary glands of patients with SjD are sites where antibody-secreting cells accumulate and secrete immunoglobulins. Many patients with dry manifestations who do not meet classification criteria are grouped as non-Sjögren's sicca (NSS) and are heavily understudied. We undertook this cross-sectional observational study to investigate the role of salivary autoantibodies as a diagnostic tool and determine presence of salivary autoantibodies in patients with NSS. In this cross-sectional observational study, we screened whole unstimulated saliva from 446 subjects by direct enzyme-linked immunosorbent assays and capillary western blotting for anti-Ro60, anti-La, and rheumatoid factor (immunoglobulin (Ig)G and IgA) antibodies. All subjects were classified following the ACR/EULAR classification at the Oklahoma Medical Research Foundation Sjögren's Research Clinic. Patients with SjD were significantly more likely to have salivary antibodies compared with those with NSS and healthy control subjects. In this cohort, there were 88 subjects with NSS with seronegative profiles who had detectable salivary autoantibodies and objective measures of dryness. Of these 88 subjects with NSS, we identified 75 subjects that had positive objective examinations of dryness and could belong to an early-onset SjD group. Alternatively, these 75 subjects with NSS could belong to a distinct phenotype of SjD that will remain seronegative while being saliva positive for anti-Ro60. These data showed a relationship between ocular and oral dryness and the presence of salivary anti-Ro60 antibodies in subjects with NSS.
Vesical Mucosal Graft for the Treatment of Ureteral Strictures with a Total Robot-assisted Approach
Authors: Ivano Morra, Giovanni Busacca, Paola Irene Ornaghi, Roberta Aimar, Filippo Poletti, Luciano Ola, Juliette Meziere, Bianca Sabrina Ribolzi, Ettore Dalmasso
Journal: European Urology (2025)
Characterizing predictors of response to behavioral interventions for children with autism spectrum disorder: A meta-analytic approach
Authors: Lacey Chetcuti, Mirko Uljarević, Rachel K Schuck, Antonio Y Hardan, Grace W Gengoux, David Trembath, Yagnesh Vadgama, Kandice J Varcin, Giacomo Vivanti, Andrew J O Whitehouse, Maria Helton, Thomas W Frazier
Journal: Clinical Psychology Review (2025)
Response to Lee and Tung “Critical Considerations Remain for Utilizing Artificial Intelligence Chatbot to Translate Dermatopathology Reports”
Authors: Yuying Zhang, Ryan Chen, Dan Nguyen, Stephanie Choi, Colleen Gabel, Nicholas Leonard, Kaitlyn Yim, Patrick O'Donnell, Zendee Elaba, April Deng, Nikki A Levin
Journal: Journal of the American Academy of Dermatology (2025)
Enhancing organoid technology with carbon-based nanomaterial biosensors: Advancements, challenges, and future directions
Authors: Zahra Rezaei, Niyou Wang, Yipei Yang, Kannan Govindaraj, Jose Joaquin Velasco, Alvaro Dario Martinez Blanco, Nam Ho Bae, HeaYeon Lee, Su Ryon Shin
Journal: Advanced Drug Delivery Reviews (2025)
Delivery of Itgb1-siRNA by triptolide-modified and anti-Flt1 peptide-guided ionizable cationic LNPs for targeted therapy of corneal neovascularization
Authors: Yuwen Song, Tingting Xu, Hao Li, Jing Liu, Shumin Cao, Yichen Yang, Nianlu Li, Peiwen Lv, Min Han, Haohan Sun, Guangfu Dang, Jianxin Li, Hao Sun, Tao Xin, Huitang Xia, Canwei Zhang
Journal: Journal of Controlled Release (2025)
Cardiosplenic axis-targeted immunomodulatory liposome for myocardial ischemia-reperfusion injury treatment
Authors: Jiankai Dong, Zechuan Li, Chenxing Fu, Ding Yang, Huijie Yang, Li Lin, Xing-Jie Liang, Zhaoyang Chen, Lianglong Chen, Weisheng Guo
Journal: Journal of Controlled Release (2025)
Event‐free survival in early polycythemia vera patients correlates with molecular response to ropeginterferon alfa‐2b or hydroxyurea/best available therapy (PROUD‐PV/CONTINUATION‐PV)
Authors: Jean‐Jacques Kiladjian, Christoph Klade, Pencho Georgiev, Dorota Krochmalczyk, Liana Gercheva‐Kyuchukova, Miklos Egyed, Petr Dulicek, Arpad Illes, Halyna Pylypenko, Lylia Sivcheva, Jiří Mayer, Vera Yablokova, Kurt Krejcy, Victoria Empson, Hans C. Hasselbalch, Robert Kralovics, Heinz Gisslinger
Journal: HemaSphere (2025)
Thrombotic Thrombocytopenic Purpura (<scp>TTP</scp>) Survivors Exhibit Impaired Stress Perfusion on Cardiac <scp>MRI</scp>
Authors: Senthil Sukumar, Leah Danish, Yuchi Han, Spero Cataland
Journal: American Journal of Hematology (2025)

Stress images are on the left and rest images are on the right. The top row is a TTP subject and the bottom row is a control subject. The color maps show myocardial blood flow (MBF) in ml/g/min with brighter colors indicating higher perfusion. Stress imaging of the TTP patient shows decreased MBF compared with control, primarily noted in the subendocardium. The rest images do not show any significant difference in MBF at rest.
Re: Richard J. Bryant, Ioana R. Marian, Roxanne Williams, et al. Local anaesthetic transperineal biopsy versus transrectal prostate biopsy in prostate cancer detection (TRANSLATE): a multicentre, randomised, controlled trial. Lancet Oncol. In press. https://doi.org/10.1016/s1470-2045(25)00100-7
Authors: Alessandro Uleri, Michael Baboudjian, Guillaume Ploussard
Journal: European Urology (2025)
Re: Douglas M. Dahl, Joseph P. Rodgers, William U. Shipley, et al. Bladder-preserving Trimodality Treatment for High-grade T1 Bladder Cancer: Results From Phase II Protocol NRG Oncology/RTOG 0926. J Clin Oncol 2024;42:4095–102
Authors: Paolo Zaurito, Marco Moschini, Alberto Briganti, Francesco Montorsi
Journal: European Urology (2025)
Dental Management of Patients on Anticoagulant and Antiplatelet Therapy: A Comprehensive Clinical Guide
Authors: Ashish Pandey
Journal: Clinical Cardiology and Cardiovascular Interventions (2025)

The increasing prevalence of patients on anticoagulant and antiplatelet therapy presents significant considerations for dental practitioners, particularly concerning bleeding risks during invasive procedures. This article provides an updated, evidence-based guide for managing such patients, emphasizing a balance between minimizing bleeding complications and preventing thromboembolic events. Key areas discussed include pharmacological insights, preoperative assessments, procedural adaptations, local hemostatic techniques, and postoperative care. The guidance aligns with the latest clinical recommendations to ensure safe and effective dental care.
Unforeseen Threats: Mechanical Complications in the Aftermath of Acute Coronary Syndromes
Authors: Rim Zerhoudi
Journal: Clinical Cardiology and Cardiovascular Interventions (2025)

Introduction: Acute coronary syndromes (ACS) are cardiovascular emergencies resulting from the rupture or erosion of atherosclerotic plaque in the coronary arteries. Despite therapeutic advances that have reduced mortality, serious mechanical complications, such as myocardial rupture, acute valvular insufficiency and ventricular septal defect, can still occur, increasing the risk of mortality. The present work aims to describe mechanical complications in ACS in our setting, examine their frequencies, pathophysiological mechanisms and therapeutic approaches through our series and literature review. Materials and methods: This retrospective study included 20 patients with mechanical complications of myocardial infarction, mainly diagnosed at the thoracic pain unit of the Mohammed VI University Hospital, Marrakech, and hospitalized in cardiology over a two-year period. Selected patients presented with myocardial rupture, acute mitral insufficiency, interventricular septal rupture, right ventricular free wall rupture or left ventricular aneurysm. Data on incidence, diagnosis and clinical outcome were analyzed. Results: During the study period, 20 patients, with a mean age of 69 and a female predominance, presented with post-infarction mechanical complications without a history of ischemic heart disease. The main complications included ventricular septal defects (50%), intramyocardial dissections (15%), acute mitral insufficiency (15%) and ventricular wall rupture. Echocardiography enabled rapid diagnosis. Half the patients were stable on admission, while three quarters progressed to cardiogenic shock, often fatal. Discussion and conclusion: Mechanical complications of ACS are rare but serious events that complicate patients' prognosis. Early detection by echocardiography or cardiac MRI, followed by surgical management, remains crucial to improving survival. Advances in early revascularization, notably coronary angioplasty, have helped to reduce the incidence of these complications, but optimal treatment of advanced cases relies on an experienced multidisciplinary team.
Unroofing of Anomalous Right Coronary Artery: Interesting Images
Authors: Ajmer Singh
Journal: Clinical Cardiology and Cardiovascular Interventions (2025)

Anomalous origin of the coronary artery from the opposite sinus can potentially lead to life-threatening complications including myocardial infarction, arrhythmia, or sudden death. The interarterial course between the aortic root and pulmonary artery, the so-called malignant course, can cause compression of the artery; and can lead to adverse outcomes including death. The unroofing technique is suitable for those with intramural course, and it creates a new coronary ostium in the correct sinus of Valsalva. We describe a thirteen-year-old patient with an anomalous right coronary artery arising from the left sinus of Valsalva. The interarterial course of the right coronary artery was lying between the aorta and pulmonary artery. The patient underwent an unroofing of the right coronary artery and made an uneventful recovery.
Pathologies of the Cardiovascular System
Authors: Elizaveta I Bon
Journal: Clinical Cardiology and Cardiovascular Interventions (2025)

Purpose of the work: to study in detail the pathologies of the cardiovascular system in children and adults Heart failure is a syndrome of symptoms and signs caused by cardiac dysfunction, resulting in reduced life expectancy. To establish the diagnosis of heart failure, the guidelines of the European Society of Cardiology require the presence of symptoms and signs, objective evidence of cardiac dysfunction (preferably by echocardiography) and, in case of remaining doubt, a favourable response to treatment directed at heart failure. Numerous compensatory mechanisms are involved in supporting the heart in heart failure, including activation of the neurohormonal system.
Expert of Experts Verification and Alignment (EVAL) Framework for Large Language Models Safety in Gastroenterology
Authors: Mauro Giuffrè, Kisung You, Ziteng Pang, Simone Kresevic, Sunny Chung, Ryan Chen, Youngmin Ko, Colleen Chan, Theo Saarinen, Milos Ajcevic, Lory S Crocè, Guadalupe Garcia-Tsao, Ian Gralnek, Joseph J Y Sung, Alan Barkun, Loren Laine, Jasjeet Sekhon, Bradly Stadie, Dennis L Shung
Journal: npj Digital Medicine (2025)

Large language models generate plausible text responses to medical questions, but inaccurate responses pose significant risks in medical decision-making. Grading LLM outputs to determine the best model or answer is time-consuming and impractical in clinical settings; therefore, we introduce EVAL (Expert-of-Experts Verification and Alignment) to streamline this process and enhance LLM safety for upper gastrointestinal bleeding (UGIB). We evaluated OpenAI's GPT-3.5/4/4o/o1-preview, Anthropic's Claude-3-Opus, Meta's LLaMA-2 (7B/13B/70B), and Mistral AI's Mixtral (7B) across 27 configurations, including zero-shot baseline, retrieval-augmented generation, and supervised fine-tuning. EVAL uses similarity-based ranking and a reward model trained on human-graded responses for rejection sampling. Among the employed similarity metrics, Fine-Tuned ColBERT achieved the highest alignment with human performance across three separate datasets (ρ = 0.81-0.91). The reward model replicated human grading with 87.9% of cases across temperature settings and significantly improved accuracy through rejection sampling by 8.36% overall. EVAL offers scalable potential to assess accuracy for high-stakes medical decision-making.