tbuckley/cabot-search huggingface dataset:
New Genetic Biomarkers to Diagnose Pediatric Appendicitis
Authors: Maurizio Pacilli, Rishikesan Kamaleswaran
Journal: JAMA Pediatrics (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Neighborhood Segregation and Access to Live Donor Kidney Transplantation
Authors: Yiting Li, Gayathri Menon, Byoungjun Kim, Sunjae Bae, Evelien E. Quint, Maya N. Clark-Cutaia, Wenbo Wu, Valerie L. Thompson, Deidra C. Crews, Tanjala S. Purnell, Roland J. Thorpe, Sarah L. Szanton, Dorry L. Segev, Mara A. McAdams DeMarco
Journal: JAMA Internal Medicine (2024)

Identifying the mechanisms of structural racism, such as racial and ethnic segregation, is a crucial first step in addressing the persistent disparities in access to live donor kidney transplantation (LDKT).
Pitfalls of Cuff Size and Blood Pressure Measurement—Reply
Authors: Junichi Ishigami, Lawrence J. Appel, Tammy M. Brady
Journal: JAMA Internal Medicine (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Correction: Respectful Maternity Care
Authors: Amy G. Cantor, MD, MPH, Rebecca M. Jungbauer, DrPH, MA, Andrea C. Skelly, PhD, MPH, Erica L. Hart, MST, Katherine Jorda, MD
Journal: Annals of Internal Medicine (2024)

Corrections20 February 2024Correction: Respectful Maternity CareFREEThis correction concerns the following article:ReviewsJan 2024Respectful Maternity CareFREEAmy G. Cantor, MD, MPH, Rebecca M. Jungbauer, DrPH, MA, Andrea C. Skelly, PhD, MPH, Erica L. Hart, MST, Katherine Jorda, MDAmy G. Cantor, MD, MPHPacific Northwest Evidence-based Practice Center, Department of Medical Informatics and Clinical Epidemiology; Department of Family Medicine; and Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon (A.G.C.), Rebecca M. Jungbauer, DrPH, MAPacific Northwest Evidence-based Practice Center, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon (R.M.J., E.L.H., C.D.), Andrea C. Skelly, PhD, MPHPacific Northwest Evidence-based Practice Center, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon, and Aggregate Analytics, Fircrest, Washington (A.C.S.), Erica L. Hart, MSTPacific Northwest Evidence-based Practice Center, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon (R.M.J., E.L.H., C.D.), Katherine Jorda, MDDepartment of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon (K.J., A.B.C.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L24-0036 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the review by Cantor and colleagues (1), the authors identified errors in Tables 3 and 4. In Table 3, one of the studies of the Person-Centered Maternity Care scale was corrected to 35 items rather than 32 as originally written and the quality assessment category for reference 55 was revised from poor quality to fair quality. In Table 4, many checkmarks were in the incorrect location. These have been revised to correctly reflect the content of the validated tools.The tables have been corrected accordingly. These errors do not affect the overall content, results, main conclusions, or findings of the review.Reference1. Cantor AG, Jungbauer RM, Skelly AC, et al. Respectful maternity care. A systematic review. Ann Intern Med. 2024;177:50-64. [PMID: 38163377] doi:10.7326/M23-2676 LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationThis article was published at Annals.org on 20 February 2024. Nextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRespectful Maternity Care Amy G. Cantor , Rebecca M. Jungbauer , Andrea C. Skelly , Erica L. Hart , Katherine Jorda , Cynthia Davis-O'Reilly , Aaron B. Caughey , and Ellen L. Tilden Metrics Latest ePublished: 20 February 2024 Copyright & PermissionsCopyright © 2024 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Correction: Personalized Estimates of Benefit From Preventive Care Guidelines
Authors: Glen B. Taksler, PhD, Melanie Keshner, MSN, FNP, Angela Fagerlin, PhD, Negin Hajizadeh, MD, MPH, R. Scott Braithwaite, MD, MSc
Journal: Annals of Internal Medicine (2024)

Corrections20 February 2024Correction: Personalized Estimates of Benefit From Preventive Care GuidelinesFREEThis correction concerns the following article:Original ResearchAug 2013Personalized Estimates of Benefit From Preventive Care GuidelinesGlen B. Taksler, PhD, Melanie Keshner, MSN, FNP, Angela Fagerlin, PhD, Negin Hajizadeh, MD, MPH, and R. Scott Braithwaite, MD, MScGlen B. Taksler, PhDFrom New York University School of Medicine, New York, New York, and University of Michigan, Ann Arbor, Ann Arbor, Michigan., Melanie Keshner, MSN, FNPFrom New York University School of Medicine, New York, New York, and University of Michigan, Ann Arbor, Ann Arbor, Michigan., Angela Fagerlin, PhDFrom New York University School of Medicine, New York, New York, and University of Michigan, Ann Arbor, Ann Arbor, Michigan., Negin Hajizadeh, MD, MPHFrom New York University School of Medicine, New York, New York, and University of Michigan, Ann Arbor, Ann Arbor, Michigan., and R. Scott Braithwaite, MD, MScFrom New York University School of Medicine, New York, New York, and University of Michigan, Ann Arbor, Ann Arbor, Michigan.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L24-0039 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the article by Taksler and colleagues (1), Supplement 1 was missing inserted formulas because of a file conversion error. A corrected file with the formulas present has been uploaded.Reference1. Taksler GB, Keshner M, Fagerlin A, et al. Personalized estimates of benefit from preventive care guidelines. A proof of concept. Ann Intern Med. 2013;159:161-168. doi:10.7326/0003-4819-159-3-201308060-00005. [PMID: 23922061] LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationThis article was published at Annals.org on 20 February 2024. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPersonalized Estimates of Benefit From Preventive Care Guidelines Glen B. Taksler , Melanie Keshner , Angela Fagerlin , Negin Hajizadeh , and R. Scott Braithwaite Metrics Latest ePublished: 20 February 2024 Copyright & PermissionsCopyright © 2024 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Reassuring pregnancy outcomes in women with mild COL4A3-5–related disease (Alport syndrome) and genetic type of disease can aid personalized counseling
Authors: Margriet E. Gosselink, Rozemarijn Snoek, Agne Cerkauskaite-Kerpauskiene, Sophie P.J. van Bakel, Renee Vollenberg, Henk Groen, Rimante Cerkauskiene, Marius Miglinas, Rossella Attini, Kálmán Tory, Kathleen J. Claes, Kristel van Calsteren, Aude Servais, Margriet F.C. de Jong, Valentine Gillion, Liffert Vogt, Antonio Mastrangelo, Monica Furlano, Roser Torra, Kate Bramham, Kate Wiles, Elizabeth R. Ralston, Matthew Hall, Lisa Liu, Michelle A. Hladunewich, A. Titia Lely, Albertien M. van Eerde
Journal: Kidney International (2024)

Individualized pre-pregnancy counseling and antenatal care for women with chronic kidney disease (CKD) require disease-specific data. Here, we investigated pregnancy outcomes and long-term kidney function in women with COL4A3-5 related disease (Alport Syndrome, (AS)) in a large multicenter cohort. The ALPART-network (mAternaL and fetal PregnAncy outcomes of women with AlpoRT syndrome), an international collaboration of 17 centers, retrospectively investigated COL4A3-5 related disease pregnancies after the 20th week. Outcomes were stratified per inheritance pattern (X-Linked AS (XLAS)), Autosomal Dominant AS (ADAS), or Autosomal Recessive AS (ARAS)). The influence of pregnancy on estimated glomerular filtration rate (eGFR)-slope was assessed in 192 pregnancies encompassing 116 women (121 with XLAS, 47 with ADAS, and 12 with ARAS). Median eGFR pre-pregnancy was over 90ml/min/1.73m
Annals On Call - Encouraging Influenza Vaccination
Authors: Robert M. Centor, Mark W. Tenforde, Fatimah S. Dawood
Journal: Annals of Internal Medicine (2024)

Web ExclusivesFebruary 2024Annals On Call - Encouraging Influenza VaccinationFREERobert M. Centor, MD, Mark W. Tenforde, MD, PhD, MPH, DTM&H, and Fatimah S. Dawood, MDRobert M. Centor, MDHuntsville Regional Medical Campus, University of Alabama Birmingham School of Medicine, Birmingham, Alabama (R.M.C.), Mark W. Tenforde, MD, PhD, MPH, DTM&HInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia (M.W.T., F.S.D.), and Fatimah S. Dawood, MDInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia (M.W.T., F.S.D.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/A23-0004 CME/MOC SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In this episode of Annals On Call, Dr. Centor discusses encouraging patients to receive influenza vaccination with Drs. Mark Tenforde and Fatimah Dawood.Annals articles discussed include...Communicating the Value of Influenza Vaccines to Patients: Translating Vaccine Effectiveness to Acceptance: https://www.acpjournals.org/doi/10.7326/M23-2802About Annals On CallAnnals On Call focuses on a clinically influential article published in Annals of Internal Medicine. Dr. Robert Centor shares his own perspective on the material and interviews topic area experts to discuss, debate, and share diverse insights about patient care and health care delivery.For more information on Annals On Call and for more episodes, visit go.annals.org/OnCall. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAuthors: Robert M. Centor, MD; Mark W. Tenforde, MD, PhD, MPH, DTM&H; Fatimah S. Dawood, MDAffiliations: Huntsville Regional Medical Campus, University of Alabama Birmingham School of Medicine, Birmingham, Alabama (R.M.C.)Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia (M.W.T., F.S.D.)Disclosures: All relevant financial relationships have been mitigated. Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=A23-0004.Editors' Disclosures: The editors have no relevant financial relationships to disclose. Individual forms may be viewed at www.annals.org/editorsdisclosures. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCommunicating the Value of Influenza Vaccines to Patients: Translating Vaccine Effectiveness to Acceptance Mark W. Tenforde , Fatimah S. Dawood , Sascha R. Ellington , Lisa A. Grohskopf , Brendan Flannery , Shikha Garg , and Carrie Reed Metrics Current IssueFebruary 2024Volume 177, Issue 2 ePublished: 20 February 2024 Issue Published: February 2024 Copyright & PermissionsCopyright © 2024 by American College of Physicians. All Rights Reserved.Loading ...
On the Pineal Gland
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2024)

Ad LibitumFebruary 2024On the Pineal GlandJack Coulehan, MDJack Coulehan, MDCenter for Medical Humanities, Compassionate Care, and Bioethics at Stony Brook University, Stony Brook, New YorkAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M23-1760 Audio Reading - “On the Pineal Gland” Supplement. Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “On the Pineal Gland” by Jack Coulehan Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail An insignificant pinecone stuck betweenthalamic lobes, like a dropped particle of foodlodged between cushions, a site convenientfor the grandmother of sleep to whispermelatonin, melatonin to her neighbors,but not the location of the soul, becausethe eighty-six billion cells of the brain,after a thorough search and considerabledebate, and although it appears in manydisguises, say the soul doesn’t occupy spacein the brain. If it had a location, the gemwould’ve been stolen long ago, hiddenby natural selection, and the rest of uswould’ve forgotten and ceased searching. Author, Article, and Disclosure InformationAuthors: Jack Coulehan, MDAffiliations: Center for Medical Humanities, Compassionate Care, and Bioethics at Stony Brook University, Stony Brook, New YorkCorresponding Author: Jack Coulehan, MD; e-mail, john.coulehan@stonybrookmedicine.edu. PreviousarticleNextarticle Advertisement Audio Reading - “On the Pineal Gland” Supplement. Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “On the Pineal Gland” by Jack Coulehan Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Current IssueFebruary 2024Volume 177, Issue 2Page: 259 ePublished: 20 February 2024 Issue Published: February 2024 Copyright & PermissionsCopyright © 2024 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
AI‐Driven Design System for Fabrication of Inhalable Nanocatchers for Virus Capture and Neutralization (Adv. Healthcare Mater. 5/2024)
Authors: Hao‐Han Pang, Nan‐Si Li, Ying‐Pei Hsu, Shin‐Pon Ju, Guan‐Da Syu, Pin‐Xian Du, Chiung‐Yin Huang, Kuo‐Chen Wei, Hung‐Wei Yang
Journal: Advanced Healthcare Materials (2024)
A Smart Stimulation–Deadhesion and Antimicrobial Hydrogel for Repairing Diabetic Wounds Infected with Methicillin‐Resistant <i>Staphylococcus aureus</i> (Adv. Healthcare Mater. 5/2024)
Authors: Zhongwu Bei, Linghong Zhang, Jianan Li, Qi Tong, Kun Shi, Wen Chen, Yan Yu, Ao Sun, Yang Xu, Jie Liu, Zhiyong Qian
Journal: Advanced Healthcare Materials (2024)

Diabetes WounD DressingIn article 2303042, Zhiyong Qian and co-workers report a multifunctional hydrogel wound dressing for diabetic wounds infected with bacteria.This hydrogel dressing exhibit excellent antibacterial properties, adhesion, and mild stimulation-triggered detachment, offering a potential avenue for the development of painless antibacterial dressings.
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline
Authors: Lexiang Yu, Qianfen Wan, Qiongming Liu, Yong Fan, Qiuzhong Zhou, Alicja A. Skowronski, Summer Wang, Zhengping Shao, Chen-Yu Liao, Lei Ding, Brian K. Kennedy, Shan Zha, Jianwen Que, Charles A. LeDuc, Lei Sun, Liheng Wang, Li Qiang
Journal: Cell Metabolism (2024)
Microbial and metabolic profiles unveil mutualistic microbe-microbe interaction in obesity-related colorectal cancer
Authors: Jinming Li, Ziying Chen, Qinying Wang, Lutao Du, Yongzhi Yang, Fanying Guo, Xinxiang Li, Yanjie Chao, Yanlei Ma
Journal: Cell Reports Medicine (2024)

Obesity is a risk factor for colorectal cancer (CRC), and the involvement of gut microbiota in the pathogenesis of obesity and CRC is widely recognized. However, the landscape of fecal microbiome and metabolome distinguishing patients with obesity-related CRC from obesity remains unknown. Here, we utilize metagenomic sequencing and metabolomics from 522 patients with CRC and healthy controls to identify the characteristics of obese CRC. Our integrated analysis reveals that obesity-related CRC is characterized by elevated Peptostreptococcus stomatis, dysregulated fatty acids and phospholipids, and altered Kyoto Encyclopedia of Genes and Genomes pathways involving glycerophospholipid metabolism and lipopolysaccharide synthesis. Correlation analysis unveils microbial interactions in obesity, where the probiotic Faecalibacterium prausnitzii and the tumor-promoting species P. stomatis may engage in cross-feeding, thereby promoting tumorigenesis. In vitro experiments affirm enhanced growth under cross-feeding conditions. The mutualistic microbe-microbe interaction may contribute to the association between obesity and elevated CRC risk. Additionally, diagnostic models incorporating BMI-specific microbial biomarkers display promise for precise CRC screening.
Prevalence and risk factors for development of recurrent calciphylaxis
Authors: Joyce Xia, Alice J. Tan, Colleen K. Gabel, Emily D. Nguyen, Sidharth Chand, Renajd Rrapi, Allison S. Dobry, Anna Cristina Garza-Mayers, Lauren N. Ko, Radhika Shah, Jessica St. John, Sagar U. Nigwekar, Daniela Kroshinsky
Journal: Journal of the American Academy of Dermatology (2024)
Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons
Authors: Ayako Kawatake-Kuno, Haiyan Li, Hiromichi Inaba, Momoka Hikosaka, Erina Ishimori, Takatoshi Ueki, Yury Garkun, Hirofumi Morishita, Shuh Narumiya, Naoya Oishi, Gen Ohtsuki, Toshiya Murai, Shusaku Uchida
Journal: Neuron (2024)
XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1
Authors: Qian Wang, Yicheng Guo, Anthony Bowen, Ian A. Mellis, Riccardo Valdez, Carmen Gherasim, Aubree Gordon, Lihong Liu, David D. Ho
Journal: Cell Host & Microbe (2024)

COVID-19 vaccines have recently been updated to specifically encode or contain the spike protein of the SARS-CoV-2 XBB.1.5 subvariant, but their immunogenicity in humans has yet to be fully evaluated and reported, particularly against emergent viruses that are rapidly expanding. We now report that administration of an updated monovalent mRNA vaccine booster (XBB.1.5 MV) to previously uninfected individuals boosted serum virus-neutralizing antibodies significantly against not only XBB.1.5 (27.0-fold increase) and EG.5.1 (27.6-fold increase) but also key emerging viruses such as HV.1, HK.3, JD.1.1, and JN.1 (13.3- to 27.4-fold increase). Individuals previously infected by an Omicron subvariant had the highest overall serum neutralizing titers (ID
mRNA PROTACs: engineering PROTACs for high‐efficiency targeted protein degradation
Authors: Xiaoqi Xue, Chen Zhang, Xiaolin Li, Junqiao Wang, Haowei Zhang, Ying Feng, Naihan Xu, Hongyan Li, Chunyan Tan, Yuyang Jiang, Ying Tan
Journal: MedComm (2024)

Abstract Proteolysis‐targeting chimeras (PROTACs) are essential bifunctional molecules that target proteins of interest (POIs) for degradation by cellular ubiquitination machinery. Despite significant progress made in understanding PROTACs' functions, their therapeutic potential remains largely untapped. As a result of the success of highly flexible, scalable, and low‐cost mRNA therapies, as well as the advantages of the first generation of peptide PROTACs (p‐PROTACs), we present for the first time an engineering mRNA PROTACs (m‐PROTACs) strategy. This design combines von Hippel–Lindau (VHL) recruiting peptide encoding mRNA and POI‐binding peptide encoding mRNA to form m‐PROTAC and promote cellular POI degradation. We then performed proof‐of‐concept experiments using two m‐PROTACs targeting two cancer‐related proteins, estrogen receptor alpha and B‐cell lymphoma‐extra large protein. Our results demonstrated that m‐PROTACs could successfully degrade the POIs in different cell lines and more effectively inhibit cell proliferation than the traditional p‐PROTACs. Moreover, the in vivo experiment demonstrated that m‐PROTAC led to significant tumor regression in the 4T1 mouse xenograft model. This finding highlights the enormous potential of m‐PROTAC as a promising approach for targeted protein degradation therapy.
Infective Endocarditis in Patients Addicted to Injected Opioid Drugs
Authors: Michael J. Javorski, Brad F. Rosinski, Shawn Shah, Matthew A. Thompson, David Streem, Steven M. Gordon, Steven Insler, Penny L. Houghtaling, Brian Griffin, Eugene H. Blackstone, Shinya Unai, Lars G. Svensson, Gösta B. Pettersson, Haytham Elgharably
Journal: Journal of the American College of Cardiology (2024)