tbuckley/cabot-search huggingface dataset:
Abstract 14043: A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Authors: Venkatesh Mani, Sarayu Ramachandran, Nadia Alie, Gregory Piazza, Hans Lanz, Michael Grosso, Valentin Fuster, Michele Mercuri, Samuel Z Goldhaber, Zahi A Fayad
Journal: Circulation (2013)

Background: Compression ultrasound (CUS) is used to diagnose acute deep venous thrombosis (DVT). However, CUS cannot assess pelvic veins or quantify thrombus volume. In a study of edoxaban monother...
THE DOCTOR, THE PATIENT, AND THE TRUTH
Authors: C C LUND
Journal: Annals of Internal Medicine (1946)

Article1 June 1946THE DOCTOR, THE PATIENT, AND THE TRUTHCHARLES C. LUND, M.D.CHARLES C. LUND, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-6-955 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen Pilate asked Jesus, "What is the truth?", He did not answer.1After a doctor has completed a careful examination he will frequently be in possession of information about a patient that will indicate to him quite definitely that the patient is suffering from a serious disease which is in a probably or possibly curable condition if a certain course of treatment or of surgery is carried out promptly. Should he then and there tell the patient "the truth, the whole truth, and nothing but the truth" and then ask the patient to let him arrange for the treatment? Is...Bibliography1. St. John, 18, 38. Google Scholar2. HENDERSON LJ: Physician and patient as a social system, New England Jr. Med., 1935, ccxii, 819-823. CrossrefGoogle Scholar3. WHITEHEAD AN: Process and reality, page 11, 1929, Macmillan Co., New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication February 15, 1946.From the Department of Surgery, Harvard Medical School, and the Third Surgical Service, Boston City Hospital, Boston, Mass. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTruth and lies: Disclosure and the power of diagnosisCommunication with Cancer Patients in Culturally Diverse SocietiesPsychological problems in terminal cancer managementThe patient with inoperable cancer from the psychiatric and social standpoints.A study of 101 casesPsychogenic Factors in Surgery 1 June 1946Volume 24, Issue 6Page: 955-959KeywordsSurgery ePublished: 1 December 2008 Issue Published: 1 June 1946 Copyright & PermissionsCopyright, 1946, by The American College of PhysiciansPDF downloadLoading ...
Peripherally inserted central catheter as a predominant risk factor for candidemia in critically ill patients in Internal Medicine wards in Italy
Authors: Carlo Tascini, Emanuela Sozio, Giancarlo Tintori, Andrea Ripoli, Francesco Sbrana, Elena Rosselli Del Turco, Giacomo Bertolino, Simona Fortunato, Franco Carmassi, Gianluigi Cardinali, Francesco Menichetti
Journal: Intensive Care Medicine (2015)
Abstract MP22: Mortality Due to Sugar-Sweetened Beverage Consumption: A Global, Regional, and National Comparative Risk Assessment
Authors: Gitanjali M Singh, Renata Micha, Shahab Katibzadeh, Stephen Lim, Majid Ezzati, Dariush Mozaffarian
Journal: Circulation (2013)

Background: Sugar-sweetened beverages (SSBs) are consumed globally and contribute to adiposity. However, the worldwide quantitative impact of sugar-sweetened beverages on burdens of adiposity-relat...
Caring for Older People: Homes and Housing for Elderly People
Authors: P Wanklyn
Journal: BMJ (1996)

Most elderly people in Britain live independently in their own homes. Moving to alternative accommodation may be necessary for some people but requires careful consideration. A multidisciplinary assessment should be performed when a person plans to move into residential care; this should include the input of a doctor trained in geriatric medicine. A range of housing options is open to elderly people and these options are discussed here.
Abstract 2007: A 67-year-old Man with Waldenstrom’s Macroglobulinemia, Heart Failure, and a Pericardial Effusion
Authors: Duy T Nguyen, Yerem Yeghiazarians, Philip C Ursell, Michael H Crawford
Journal: Circulation (2006)

A 67-year-old man with Waldenstrom’s macroglobulinemia and renal failure was admitted for fatigue. On exam, he had signs of congestive heart failure. His electrocardiogram revealed low voltages. A ...
SPECT with N-lsopropyl-p lodoamphetamine in Occlusive Cerebrovascular Diseases
Authors: TOSHIAKI HIGA, TOMOJI TANAKA, KATSUJI IKEKUBO, TAKASHI KOMATSU, KANJI TORIZUKA
Journal: Clinical Nuclear Medicine (1986)

The role of SPECT imaging with N-isopropyl-p iodoamphetamine (I-123 IMP) in the detection of angiographically documented occlusive cerebrovascular diseases was evaluated in 24 patients, and the results of regional cerebral blood flow (rCBF) were compared with x-ray CT. Twelve patients had internal carotid occlusion, ten had intracranial occlusion beyond the circle of Willis, one had common carotid occlusion, and one had basilar artery occlusion. SPECT images were obtained with a gamma camera, which was rotated 360° around the patient's head 30 minutes after an intravenous injection of 3 mCi of I-123 IMP. CT images in the transverse plane were obtained, and the regions of reduced attenuation were identified for comparison of topographic extension of the lesion with the regions of decreased rCBF seen on SPECT. In six cases, the lesions seen on the SPECT images were distinctly more extensive than those seen on CT. In the remaining 18 cases, the extent of the lesion was identical on both CT and SPECT images. Radiochemical and radionuclide impurities, the distance of the detector from the head, and the nature of the collimator affected the SPECT results. I-123 IMP SPECT imaging complements CT findings in detecting the ischemic zones beyond the regions identified on CT images, and may have a major rule in the management of patients with occlusive cerebrovascular diseases.
Abstract 1512: Heteromeric Assembly of HCN4 and C-Terminal Truncated HCN2 Subunits in the Generation of Cardiac Pacemaker (If) Channels
Authors: Bin Ye, Jeanne Nerbonne
Journal: Circulation (2008)

In sino-atrial and atrio-ventricular nodal cells, hyperpolarization- activated cyclic nucleotide-gated (HCN) cationic channels are expressed that carry inward currents, I f , contributing importantly to the diastolic depolarization critical for cardiac pacemaker functioning. Although previous studies have demonstrated myocardial expression of HCN2 and HCN4 subunits, the roles of these subunits in the generation of mature, functional I f channels remains unclear. In preliminary experiments, completed on transiently transfected HEK293 cells expressing wild type and dominant negative mutant HCN2 and HCN4 subunits, we find that HCN2 and HCN4 preferentially co-assemble to form heteromeric channels. In further studies focused on defining the molecular compositions of functional cardiac I f channels, we developed and validated C-and N-terminal HCN2 and HCN4 subunit specific antibodies and exploited these to identify the HCN subunits expressed in adult (mouse) heart and to immunoprecipitate cardiac HCN-encoded I f channel complexes. These experiments revealed that the HCN2 and HCN4 proteins co-immunoprecipitate from heart, In addition, Western blot experiments revealed that, although the full length HCN2 (105Da) and HCN4 (160Da) proteins are expressed in transiently transfected HEK293 cells and in adult (mouse) brain, the molecular weight of the HCN2 protein in the heart is reduced to about 60 kDa. In addition, the mature, 60 kDa HCN2 protein lacks the C-terminal cAMP binding domain. These observations likely explain the results of previous studies demonstrating that the targeted deletion of HCN2 does not affect the cAMP sensitivity of I f . In addition, taken together, these results demonstrate that functional myocardial I f channels reflect the heteromeric assembly of HCN2 and HCN4 subunits and further that the HCN4 subunit regulates cAMP-mediated regulation of I f channels. This research has received full or partial funding support from the American Heart Association, AHA National Center.
Abstract P167: The Long-term Effect of a Low-Carbohydrate Diet on Appetite Hormones: A Randomized Controlled Trial
Authors: Tian Hu, Kristi Reynolds, Lu Yao, Calynn Bunol, Yanxi Liu, Chung-Shiuan Chen, Jiang He, Lydia Bazzano
Journal: Circulation (2013)

The long-term effects of low-carbohydrate diets on hormones related to appetite are unclear. We recruited a total of 148 study participants with a body mass index of 30 - 45 kg/m2 (Mean: 35.4 kg/m2) who were free of diabetes, cardiovascular diseases and kidney disease. The participants were randomly assigned to either a low-carbohydrate diet (&lt;40 g/day; N=75) or a low fat (&lt;30% energy from fat, &lt;10% from saturated fat; N=73) diet. Two 24-hour dietary recalls were conducted at each clinic visit (0, 3, 6 and 12 months of the intervention). Participants met with a study dietitian weekly for the first month followed by group settings bi-weekly for 5 months then monthly for the subsequent 6 months. Each group was provided the same behavioral curriculum related to diet emphasizing portion control and eating habits. Total ghrelin and peptide YY were determined using radioimmunoassay methods. Of the study participants, 60 in the low-fat group (81.1%) and 59 in the low-carbohydrate group (79.7%) completed the entire intervention. The mean age was 46.8 years, 88.5% were women and 55.1% were African-Americans. The low-carbohydrate group lost approximately 3.5 kg more body weight than did the low-fat group (P value: 0.002) over the course of the intervention. Both diets decreased total peptide YY and ghrelin. Compared to low-fat diets, the low-carbohydrate diet resulted in a significantly greater decrease in total peptide YY at 6 (Net change: -6.8 ph/mL; P value: 0.04) and 12 months (Net change: -10.6 ph/mL; P value: 0.02). The changes in total ghrelin were not significantly different throughout the study. Our findings suggest that the low-carbohydrate diet did not result in a greater loss of appetite, compared to the low-fat diet.
Fishing in the Heart
Authors: José Manuel Montero-Cabezas, María Teresa Velázquez-Martín, Sagrario Fernández-Casares, Agustín Albarrán-González-Trevilla, Beatriz López-Melgar, Jorge Centeno-Rodríguez, Juan Carlos Tascón-Pérez
Journal: Journal of the American College of Cardiology (2013)
Abstract 14321: MURC/Cavin-4, a Muscle-Specific Caveolae-Related Protein, Mediates the Development of Pulmonary Arterial Hypertension Through Enhanced G{alpha}13/p115RhoGEF/RhoA Signaling
Authors: Naohiko Nakanishi, Takehiro Ogata, Kotaro Miyagawa, Daisuke Naito, Takuya Taniguchi, Tomomi Ueyama, Hiroaki Matsubara
Journal: Circulation (2012)

[Background] Pulmonary arterial hypertension (PAH) is a progressive disease associated with poor clinical outcome. MURC (muscle-restricted coiled-coil protein)/Cavin-4 is a fourth member of the cav...
Abstract 165: Percutaneous Left Ventricular Support Improves Survival in Patients Undergoing Emergency Percutaneous Coronary Intervention After Cardiac Arrest Complicating STEMI
Authors: Atman P Shah, Janet Karol, Jacob Doll, Aashna Patel, Sandeep Nathan, Neeraj Jolly
Journal: Circulation (2011)

Introduction: Patients with acute ST segment elevation myocardial infarction (STEMI) and cardiac arrest have a very poor prognosis, primarily due to low success rates of cardiopulmonary resuscitati...
Epidemiological review of lymphoma diagnosis in a French rural area between 2003 and 2008.
Authors: M. Touati, M. Gourin, J. Abraham, N. Weinbreck, N. Gachard, A. Olivrie-Gamaury, J. Feuillard, A. Jaccard, D. Bordessoule
Journal: Journal of Clinical Oncology (2010)

e18551 Background: An hematological regional French network was created in 2003 with the objective to obtain an epidemiological register of lymphomas (NHL) and Hodgkin lymphoma (HL) diagnosed in this area characterized by an old population, a low socio-economic level and a geographically isolated rural country. A database was developed for annotating the LNH tissue bank for transversal and clinical research projects about LNH. We presents the main results of the analysis of the cases registered between 2003 and 2008. Methods: All consecutive cases of NHL and HL histologically proved, diagnosed in the regional care network HEMATOLIM are collected prospectively since 2003 from the multidisciplinary meetings and registrated. A statistical analysis of main characteristics of this cases was realised with Statview. Results: Between 2003-2008: 1,036 cases were included: 901 NHL, 135 HL. For NHL: sex ratio (SR) 1.07, median age 69 [17-94], with incidence (I) 15.3/100000 persons/y. Histology: B-cell NHL: 91%(n=820)with diffuse large B-cell lymphoma (DLBCL) 40,6% (n = 366), follicular (FL) 18,1% (n = 163), marginal zone (MZL) 12,7% (n = 114), other low grade NHL (LG) 10,2% (n = 92), mantle cell lymphoma (MCL) 6,4% (n = 58), high grade (HG) NHL non DLBCL 2,8% (n = 25). T cell NHL: 9,2% (n = 83). Initial stage AA: I 18.9%, II 11.2%, III 12.8% and IV 56.6%. Overall survival (OS) at 5 y are respectively FL: 79.2% DLBCL: 58.8%, other LG NHL: 58%, HG NHL non DLBCL: 55.4%, MZL: 54.6%, MCL :49% and T cell NHL: 36.7%. Median OS: T-cell NHL: 21.3m, MCL: 46.4m and not reached for the others. Results for HL: SR 1.5, median age 42 [16-85], I 2/100000 persons/y. Initial stage I: 11.1%, II: 51.1% III 15.6% and IV 21.5%, median OS not reached, 5 y OS 83.8%. Results on OS, EFS, TTP will be presented according to age, histology, stage, prognostic score, hospital and treatments. Conclusions: An observatory, like this network database, shows in real life the impact on overall survival of a consecutive nonselective cohort of patients and of different characteristic in terms of prognostic factors. Moreover, these studies evaluate the care access, environmental epidemiology and OS of pts outside of clinical research trials regardless of age, comorbidities and socioeconomic status. No significant financial relationships to disclose.
Intracoronary Cytoprotective Gene Therapy
Authors: Felix Woitek, Lorena Zentilin, Nicholas E. Hoffman, Jeffery C. Powers, Isabel Ottiger, Suraj Parikh, Anna M. Kulczycki, Marykathryn Hurst, Nadja Ring, Tao Wang, Farah Shaikh, Polina Gross, Harinder Singh, Mikhail A. Kolpakov, Axel Linke, Steven R. Houser, Victor Rizzo, Abdelkarim Sabri, Muniswamy Madesh, Mauro Giacca, Fabio A. Recchia
Journal: Journal of the American College of Cardiology (2015)
Abstract 5424: Hypoxia Induces the Histone Demethylase Jmjd3 and Epigenetically Reprograms Endothelial Progenitor Cells
Authors: Kisho Ohtani, Masamichi Koyanagi, Jes-Niels Boeckel, Andreas Zeiher, Stefanie Dimmeler
Journal: Circulation (2009)

Endothelial progenitor cells (EPCs) contribute to vascular repair and postnatal neovascularisation. Cell therapy using EPCs improved neovascularisation and functional recovery after ischemia. However, it has been extensively debated whether EPCs can differentiate into endothelial cells and the mechanisms of EPC differentiation are poorly understood. Endothelial differentiation requires the expression of endothelial marker genes, which are silenced by chromatin dependent repressive mechanisms such as histone H3 lysine 27 trimethylation (H3K27me3) in non-endothelial cells. We observed that induction of hind limb ischemia increased the expression of Jmjd3, which was shown to demethylate H3K27me3 thereby removing repressive histone marks. Therefore, we examined whether EPC might be reprogrammed by hypoxic/ischemic injury through epigenetic pathways. We report here that Jmjd3 was induced when EPCs were exposed to hypoxia for more than 24 hours. Hypoxia additionally stimulated the nuclear translocation of Jmjd3 in EPC as shown by immunostaining (12.0±3.2% in normoxia, 68.5±3.6% in hypoxia, Jmjd3 positive nuclei/whole nuclei). Increased expression and nuclear translocation of Jmjd3 after hypoxic stimulation was associated with a reduction of global H3K27m3. Additionally, chromatin immunoprecipitation showed that the promoter of eNOS and KDR, which is transcriptionally silenced by high levels of H3K27me3 in early EPC under normoxic conditions, is activated by hypoxia. Hypoxia induced a down-regulation of H3K27me3 (0.045±0.017% input in normoxia and 0.024±0.010% input in hypoxia at the eNOS promoter, 0.197±0.067% input in normoxia and 0.126±0.030% input in hypoxia at the KDR promoter) and increased the ratio of active versus repressive chromatin marks at the eNOS and KDR promoter. Consistently, eNOS and KDR mRNA levels in EPC were increased after hypoxia. In summary, these data demonstrate that hypoxia-induced up-regulation and translocation of the histone demethylase Jmjd3 is associated with a reduction of repressive histone marks at the promoter of endothelial genes. These findings indicate that hypoxia may epigenetically modulate endothelial commitment.
Abstract 1131: The Prognostic Utility of Secretory Phospholipase A2 in Patients With Stable Coronary Artery Disease
Authors: Michelle L O'Donoghue, Ziad Mallat, David A Morrow, Joelle Benessiano, Sarah Sloan, Alain Tedgui, Marc S Sabatine
Journal: Circulation (2009)

Background: Secretory phospholipase A2 (sPLA2) is believed to be involved in atherogenesis. To date, few prospective studies have examined the utility of sPLA2 for risk stratification. We examined ...
Indatuximab Ravtansine (BT062) in Combination with Lenalidomide and Low-Dose Dexamethasone in Patients with Relapsed and/or Refractory Multiple Myeloma: Clinical Activity in Patients Already Exposed to Lenalidomide and Bortezomib
Authors: Kevin R. Kelly, Asher Chanan-Khan, Leonard T Heffner, George Somlo, David S. Siegel, Todd Zimmerman, Anand Karnad, Nikhil C. Munshi, Sundar Jagannath, Allen L. Greenberg, Sagar Lonial, Vivek Roy, Sikander Ailawadhi, Farima Barmaki-Rad, Shailesh Chavan, Pankaj Patel, Andrea Wartenberg-Demand, Thomas Haeder, Kenneth C Anderson
Journal: Blood (2014)
Abstract 14945: Clinical and CMR Predictors of Myocardial Fibrosis in Hypertrophic Cardiomyopathy: Role of LV Wall Thickness
Authors: Tevfik F Ismail, Andrew Jabbour, Bibek Das, Thomas Cowling, Niraj Mistry, Ankur Gulati, Ricardo Wage, Susan Clark, Carl Shakespeare, Amanda Varnava, Dudley J Pennell, Sanjay K Prasad
Journal: Circulation (2011)

Background: Current risk stratification of patients with hypertrophic cardiomyopathy (HCM) relies upon the identification of risk markers which indirectly reflect disease severity. Individually how...
Pediatric Basic and Advanced Life Support Chapter Collaborators: Part 10: pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Authors: ME Kleinman, AR De Caen, L. Chameides, Dl. Atkins, RA Berg, Berg, F. Bhanji, Dominique Biarent, Robert Bingham, A. Coovadia, MF Hazinski, RW Hickey, Vm. Nadkarni, AG Reis, Antonio Rodriguez Nunez, J. Tiballs, Al. Zaritsky, David Zideman
Journal: Circulation (2010)
241. Effects of the Sustained Expression of GDNF in Fetal Dopaminergic Grafts
Authors: Enni Lehtonen, David Blum, Olivier Bockstael, Abdelwahed Chtarto, Catherine Melas, Marc Peschanski, Thierry Velu, Jacques Brotchi, Marc Levivier, Liliane Tenenbaum
Journal: Molecular Therapy (2003)
Abstract 10353: Changes in the Mitral Annulus Geometry in Patients After Transcatheter Aortic Valve Implantation
Authors: Robert Petr, See Hooi Ewe, Frank van der Kley, Nina Ajmone Marsan, Meindert Palmen, Arend de Weger, Martin J Schalij, Jeroen J Bax, Victoria Delgado
Journal: Circulation (2011)
The function of tumor suppressor genes in ovarian cancer: the role of LSAMP
Authors: Melanie Spears, Genevieve J. Rabiasz, Diane Scott, Evangelos Ntougkos, Scott Fegan, Eric P. Miller, John F. Smyth, Grant C. Sellar
Journal: Cancer Research (2006)

2482  We have investigated the relationship between LSAMP (limbic system-associated membrane protein) expression and human sporadic epithelial ovarian cancer (EOC) to determine whether LSAMP is a candidate tumor suppressor. LSAMP is a member of the IgLON family of immunoglobulin domain-containing glycosylphosphatidylinositol-anchored cell adhesion molecules. The IgLONs comprise LSAMP, OPCML (opioid binding protein cell adhesion molecule-like), HNT (Neurotrimin) and NEGR1/Kilon (neuronal growth regulator 1). IgLONs may function mainly as heterodimers termed Diglons. We previously demonstrated tumor suppressor function for OPCML and also an association of altered IgLON expression, including LSAMP, in EOC. LSAMP is also a candidate tumor suppressor in clear cell renal cell carcinoma. Two alternative exons encoding LSAMP signal peptides have been identified: 1a & 1b. CpG island methylation was detected by methylation-specific PCR (MS-PCR). In ovarian tumors, methylation at exons 1a and 1b was detected in 46% (n=68) and 20% (n=60) of cases, respectively. Normal ovaries were unmethylated (n=13). Somatic methylation at exons 1a and 1b was found in 79% (n=15) and 54% (n=11) of cases, respectively. In cancer cell lines methylation associated with exons 1a and 1b was 90% and 51% (n=84), respectively. Isoform non-specific quantitative RT-PCR in cancer cell lines demonstrated low levels of LSAMP expression, with the exception of SKOV-3 and PEO16. There was no evidence of correlation between methylation status and expression level in the cell lines. In addition, azacytidine treatment of SKOV-3 cells resulted in decreased LSAMP expression, suggesting that a mechanism other than CpG island methylation may influence expression. Stable transfection of SKOV-3 with sense and antisense LSAMP constructs (exon 1b isoform) generated cell lines for functional analyses. This resulted in elevated and reduced levels of LSAMP expression, respectively. The antisense cell lines displayed suppressed cell growth in both in vitro and in vivo (sub-cutaneous and intra-peritoneal) assays. Of two sense cell lines, one displayed enhanced growth in vivo but not in vitro, whereas the other displayed suppressed growth in both assays. The LSAMP sense cell lines show decreased migration towards fibronectin compared to control cells. Our data suggests the involvement of altered LSAMP expression in ovarian carcinogenesis. We present evidence that LSAMP is inactivated in EOC and that methylation is common in ovarian tumors. LSAMP may function as a suppressor of migration towards extracellular matrix components, fibronectin in particular. The evaluation of LSAMP function is complex and may be dependent upon, and indeed may influence or be influenced by, the expression of other IgLONs, including the tumor suppressor OPCML. Further functional studies are ongoing to elucidate the precise role of LSAMP and other IgLONs in EOC.