tbuckley/cabot-search huggingface dataset:
Association of Autoimmune Diseases With Coronary Atherosclerosis Severity and Ischemic Events
Authors: Martin Bødtker Mortensen, Jesper Møller Jensen, Niels Peter Rønnow Sand, Kristian Kragholm, Michael J. Blaha, Erik Lerkevang Grove, Henrik Toft Sørensen, Kevin Olesen, Michael Maeng, Brian Løgstrup, Martin Busk, Ellen Margrethe Hauge, Ann Marie Navar, Hans Erik Bøtker, Bjarne Linde Nørgaard
Journal: Journal of the American College of Cardiology (2024)
Safety concern of recombination between self-amplifying mRNA vaccines and viruses is mitigated in vivo
Authors: Tessy A H Hick, Corinne Geertsema, Wilson Nguyen, Cameron R Bishop, Linda van Oosten, Sandra R Abbo, Troy Dumenil, Frank J M van Kuppeveld, Martijn A Langereis, Daniel J Rawle, Bing Tang, Kexin Yan, Monique M van Oers, Andreas Suhrbier, Gorben P Pijlman
Journal: Molecular Therapy (2024)

Self-amplifying mRNA (SAM) vaccines can be rapidly deployed in the event of disease outbreaks. A legitimate safety concern is the potential for recombination between alphavirus-based SAM vaccines and circulating viruses. This theoretical risk needs to be assessed in the regulatory process for SAM vaccine approval. Herein, we undertake extensive in vitro and in vivo assessments to explore recombination between SAM vaccine and a wide selection of alphaviruses and a coronavirus. SAM vaccines were found to effectively limit alphavirus co-infection through superinfection exclusion, although some co-replication was still possible. Using sensitive cell-based assays, replication-competent alphavirus chimeras were generated in vitro as a result of rare, but reproducible, RNA recombination events. The chimeras displayed no increased fitness in cell culture. Viable alphavirus chimeras were not detected in vivo in C57BL/6J, Rag1
Nano‐Titanium Oxide‐Coated Carbon Nanotubes for Photothermal Therapy in the Treatment of Colorectal Cancer
Authors: Jun Xie, Da Li, Sen Niu, Yufan Sheng, Renhui Shen, Yiding He, Chenhao Xu, Ye Zhang, Tong Wang, Yuzheng Xue
Journal: Advanced Healthcare Materials (2024)

Abstract Carbon nanotubes (CNTs) display good potential in tumor photothermal therapy (PTT). In this study, it is aimed to investigate the therapeutic potential of nano‐titanium oxide‐coated multi‐walled carbon nanotubes (MCNTs) against colorectal cancer (CRC). First, TiO 2 nanosheets are modified on the surface of MCNTs to obtain nano‐TiO 2 ‐coated MCNTs. Next, cell compatibility validation is conducted on nano‐TiO 2 ‐coated MCNTs, and it is found that nano‐TiO 2 ‐coated MCNTs are safe within a certain concentration range (0–200 µg mL⁻ 1 ). Interestingly, nano‐TiO 2 ‐coated MCNTs display a good killing effect in CRC cells under near‐infrared (NIR) laser irradiation. Subsequently, nano‐TiO 2 ‐coated MCNTs markedly promote the proapoptotic effects of NIR laser irradiation and significantly inhibit the expression of cell cycle proteins CCNA1 and CCND1 in CRC cells under NIR laser irradiation, which indicates that nano‐TiO 2 ‐coated MCNTs exert anti‐CRC effects under NIR laser irradiation by regulating cell apoptosis and cell cycle. Furthermore, nano‐TiO 2 ‐coated MCNTs accelerate inhibitory effects on the AKT signaling pathway under NIR laser irradiation. Finally, a cell line‐derived xenograft model is established, and the results showed that nano‐TiO 2 ‐coated MCNTs significantly exhibit superior tumor‐killing ability under NIR laser irradiation in vivo. Collectively, these results demonstrate that nano‐TiO 2 ‐coated MCNTs with NIR laser irradiation may serve as an effective strategy for the treatment of CRC.
Contesting the BACPAP consortium's consensus – Authors' reply
Authors: Eva Kosek, Jo Nijs, Alessandro Chiarotto, Chad Cook, Lieven A Danneels, César Fernández-de-Las-Peñas, Paul W Hodges, Bart Koes, Adriaan Louw, Raymond Ostelo, Gwendolyne G M Scholten-Peeters, Michele Sterling, Othman Alkassabi, Hana Alsobayel, Darren Beales, Paraskevi Bilika, Jacqui R Clark, Liesbet De Baets, Christophe Demoulin, Rutger M J de Zoete, Ömer Elma, Annelie Gutke, Rikard Hanafi, Sabina Hotz Boendermaker, Eva Huysmans, Eleni Kapreli, Mari Lundberg, Anneleen Malfliet, Ney Meziat Filho, Felipe J J Reis, Lennard Voogt, Kory Zimney, Rob Smeets, Bart Morlion, Kurt de Vlam, Steven Z George
Journal: The Lancet Rheumatology (2024)
Call for effective therapies for preventing dementia in people with type 2 diabetes
Authors: Thomas T van Sloten, José A Luchsinger, Lenore J Launer, Mark Strachan, Tali Cukierman-Yaffe, Hertzel C Gerstein, Naveed Sattar, Geert Jan Biessels
Journal: The Lancet Diabetes & Endocrinology (2024)
School performance in children with prenatal drug exposure and out-of-home care in NSW, Australia: a retrospective population-based cohort study
Authors: Hannah Uebel, Mithilesh Dronavalli, Kate Lawler, Evelyn Lee, Barbara Bajuk, Lucinda Burns, Andrew Page, Michelle Dickson, Charles Green, Lauren Dicair, John Eastwood, Ju Lee Oei
Journal: The Lancet Child & Adolescent Health (2024)
Optical Fiber‐Enabled In Situ Photocatalytic Hydrogen Generation for Infiltrating Tumor Therapy in Brain
Authors: Hang Zhang, Shujuan Guan, Lei Wang, Min Zhang, Zhaoyin Wang, Zhihui Dai
Journal: Advanced Healthcare Materials (2024)

In addition to repressing proliferation, inhibiting the infiltration of tumor cells is an important strategy to improve the treatment of malignant tumors. Herein, a photocatalyst (pCNMC@Pt) is designed by sequentially assembling manganese dioxide, chlorin e6, and platinum (Pt) nanoparticles onto protonated graphitic carbon nitride. With the help of a Z-scheme structure and near-infrared (NIR) photosensitizer, pCNMC@Pt is capable of responding to NIR light to generate large amounts of hydrogen (H
Correlating Material Properties to Osteoprotegerin Expression on Nanoparticulate Mineralized Collagen Glycosaminoglycan Scaffolds
Authors: Wei Chen, Meiwand Bedar, Qi Zhou, Xiaoyan Ren, Youngnam Kang, Kelly X. Huang, Grace Rubino, Vasiliki Kolliopoulos, Shahrzad Moghadam, Catherine T. Cascavita, Jeremiah M. Taylor, Jose M. Chevalier, Brendan A.C. Harley, Justine C. Lee
Journal: Advanced Healthcare Materials (2024)

Abstract Precision material design directed by cell biological processes represents a frontier in developing clinically translatable regenerative technologies. While understanding cell‐material interactions on multipotent progenitor cells yields insights on target tissue differentiation, equally if not more important is the quantification of indirect multicellular interactions. In this work, the relationship of two material properties, phosphate content and stiffness, of a nanoparticulate mineralized collagen glycosaminoglycan scaffold (MC‐GAG) in the expression of an endogenous anti‐osteoclastogenic secreted protein, osteoprotegerin (OPG) by primary human mesenchymal stem cells (hMSCs) is evaluated. The phosphate content of MC‐GAG requires the type III sodium phosphate symporter PiT‐1/SLC20A1 for OPG expression, correlating with β ‐catenin downregulation, but is independent of the effects of phosphate ion on osteogenic differentiation. Using three stiffness MC‐GAG variants that do not differ significantly by osteogenic differentiation, it is observed that the softest material elicited ≈1.6–2 times higher OPG expression than the stiffer materials. Knockdown of the mechanosensitive signaling axis of YAP, TAZ, β ‐catenin and combinations thereof in hMSCs on MC‐GAG demonstrates that β‐catenin downregulation increases OPG expression by 1.5‐fold. Taken together, these data constitute a roadmap for material properties that can used to suppress osteoclast activation via osteoprotegerin expression separately from the anabolic processes of osteogenesis.
Multiple Human Population Movements and Cultural Dispersal Events Shaped the Landscape of Chinese Paternal Heritage
Authors: Mengge Wang, Yuguo Huang, Kaijun Liu, Zhiyong Wang, Menghan Zhang, Haibing Yuan, Shuhan Duan, Lanhai Wei, Hongbing Yao, Qiuxia Sun, Jie Zhong, Renkuan Tang, Jing Chen, Yuntao Sun, Xiangping Li, Haoran Su, Qingxin Yang, Liping Hu, Libing Yun, Junbao Yang, Shengjie Nie, Yan Cai, Jiangwei Yan, Kun Zhou, Chuanchao Wang, Guanglin He, Chao Liu, Mengge Wang, Renkuan Tang, Libing Yun, Junbao Yang, Chuan-Chao Wang, Jiangwei Yan, Bofeng Zhu, Liping Hu, Shengjie Nie, Hongbing Yao, Bofeng Zhu, Chao Liu, Guanglin He
Journal: Molecular Biology and Evolution (2024)

Abstract Large-scale genomic projects and ancient DNA innovations have ushered in a new paradigm for exploring human evolutionary history. However, the genetic legacy of spatiotemporally diverse ancient Eurasians within Chinese paternal lineages remains unresolved. Here, we report an integrated Y-chromosome genomic database encompassing 15,563 individuals from both modern and ancient Eurasians, including 919 newly reported individuals, to investigate the Chinese paternal genomic diversity. The high-resolution, time-stamped phylogeny reveals multiple diversification events and extensive expansions in the early and middle Neolithic. We identify four major ancient population movements, each associated with technological innovations that have shaped the Chinese paternal landscape. First, the expansion of early East Asians and millet farmers from the Yellow River Basin predominantly carrying O2/D subclades significantly influenced the formation of the Sino-Tibetan people and facilitated the permanent settlement of the Tibetan Plateau. Second, the dispersal of rice farmers from the Yangtze River Valley carrying O1 and certain O2 sublineages reshapes the genetic makeup of southern Han Chinese, as well as the Tai-Kadai, Austronesian, Hmong-Mien, and Austroasiatic people. Third, the Neolithic Siberian Q/C paternal lineages originated and proliferated among hunter-gatherers on the Mongolian Plateau and the Amur River Basin, leaving a significant imprint on the gene pools of northern China. Fourth, the J/G/R paternal lineages derived from western Eurasia, which were initially spread by Yamnaya-related steppe pastoralists, maintain their presence primarily in northwestern China. Overall, our research provides comprehensive genetic evidence elucidating the significant impact of interactions with culturally distinct ancient Eurasians on the patterns of paternal diversity in modern Chinese populations.
Paternal Use of Metformin During the Sperm Development Period Preceding Conception and Risk for Major Congenital Malformations in Newborns
Authors: Ran S. Rotem, Marc G. Weisskopf, Krista F. Huybrechts, Sonia Hernández-Díaz
Journal: Annals of Internal Medicine (2024)

Metformin is the most used oral antidiabetic medication. Despite its established safety profile, it has known antiandrogenic and epigenetic modifying effects. This raised concerns about possible adverse developmental effects caused by genomic alterations related to paternal use of metformin during the spermatogenesis period preceding conception.
Metformin Use in the First Trimester of Pregnancy and Risk for Nonlive Birth and Congenital Malformations: Emulating a Target Trial Using Real-World Data
Authors: Yu-Han Chiu, Krista F. Huybrechts, Elisabetta Patorno, Jennifer J. Yland, Carolyn E. Cesta, Brian T. Bateman, Ellen W. Seely, Miguel A. Hernán, Sonia Hernández-Díaz
Journal: Annals of Internal Medicine (2024)

Metformin is a first-line pharmacotherapy for type 2 diabetes, but there is limited evidence about its safety in early pregnancy.
Immune Cell‐Based Microrobots for Remote Magnetic Actuation, Antitumor Activity, and Medical Imaging
Authors: Nihal Olcay Dogan, Eylül Suadiye, Paul Wrede, Jelena Lazovic, Cem Balda Dayan, Ren Hao Soon, Amirreza Aghakhani, Gunther Richter, Metin Sitti
Journal: Advanced Healthcare Materials (2024)

Translating medical microrobots into clinics requires tracking, localization, and performing assigned medical tasks at target locations, which can only happen when appropriate design, actuation mechanisms, and medical imaging systems are integrated into a single microrobot. Despite this, these parameters are not fully considered when designing macrophage-based microrobots. This study presents living macrophage-based microrobots that combine macrophages with magnetic Janus particles coated with FePt nanofilm for magnetic steering and medical imaging and bacterial lipopolysaccharides for stimulating macrophages in a tumor-killing state. The macrophage-based microrobots combine wireless magnetic actuation, tracking with medical imaging techniques, and antitumor abilities. These microrobots are imaged under magnetic resonance imaging and optoacoustic imaging in soft-tissue-mimicking phantoms and ex vivo conditions. Magnetic actuation and real-time imaging of microrobots are demonstrated under static and physiologically relevant flow conditions using optoacoustic imaging. Further, macrophage-based microrobots are magnetically steered toward urinary bladder tumor spheroids and imaged with a handheld optoacoustic device, where the microrobots significantly reduce the viability of tumor spheroids. The proposed approach demonstrates the proof-of-concept feasibility of integrating macrophage-based microrobots into clinic imaging modalities for cancer targeting and intervention, and can also be implemented for various other medical applications.
Sex differences in glioblastoma based on tumor subtypes
Authors: Berta Segura-Collar, Ricardo Gargini
Journal: Neuro-Oncology (2024)

Journal Article Corrected proof Sex differences in glioblastoma based on tumor subtypes Get access Berta Segura-Collar, Berta Segura-Collar Instituto de investigaciones Biomédicas I+12 (Imas12), Hospital 12 de Octubre, Madrid, SpainPathology and Neurooncology Unit, Hospital Universitario 12 de Octubre, Madrid, Spain Corresponding Author: Berta Segura-Collar, PhD, Pathology and Neurooncology Unit, Hospital Universitario 12 de Octubre, Av. de Córdoba, S/N, 28041 Madrid, Spain (bertasegura.imas12@h12o.es) https://orcid.org/0000-0001-8507-7434 Search for other works by this author on: Oxford Academic PubMed Google Scholar Ricardo Gargini Ricardo Gargini Pathology and Neurooncology Unit, Hospital Universitario 12 de Octubre, Madrid, SpainInstituto de investigaciones Biomédicas I+12 (Imas12), Hospital 12 de Octubre, Madrid, Spain Ricardo Gargini, PhD, Pathology and Neurooncology Unit, Hospital Universitario 12 de Octubre, Av. de Córdoba, S/N, 28041 Madrid, Spain (ricgargini.imas12@h12o.es) https://orcid.org/0000-0003-4032-0095 Search for other works by this author on: Oxford Academic PubMed Google Scholar Neuro-Oncology, noae089, https://doi.org/10.1093/neuonc/noae089 Published: 17 June 2024 Article history Corrected and typeset: 17 June 2024 Published: 17 June 2024
The Sybil prophecy: Searching for predictors of response to bevacizumab in glioblastoma
Authors: Martina Offi, Lucia Gabriele, Giulia Romagnoli, Liverana Lauretti, Roberto Pallini, Quintino Giorgio D’Alessandris
Journal: Neuro-Oncology (2024)

Journal Article Corrected proof The Sybil prophecy: Searching for predictors of response to bevacizumab in glioblastoma Get access Martina Offi, Martina Offi Department of Neuroscience, Catholic University School of Medicine, ItalyDepartment of Neurosurgery, Fondazione Policlinico Gemelli IRCCS, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Lucia Gabriele, Lucia Gabriele Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Giulia Romagnoli, Giulia Romagnoli Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Liverana Lauretti, Liverana Lauretti Department of Neuroscience, Catholic University School of Medicine, ItalyDepartment of Neurosurgery, Fondazione Policlinico Gemelli IRCCS, Italy https://orcid.org/0000-0001-7997-1624 Search for other works by this author on: Oxford Academic PubMed Google Scholar Roberto Pallini, Roberto Pallini Department of Neuroscience, Catholic University School of Medicine, ItalyDepartment of Neurosurgery, Fondazione Policlinico Gemelli IRCCS, Italy Corresponding Author: Roberto Pallini, MD, PhD, Department of Neuroscience, Catholic University School of Medicine, and Department of Neurosurgery, Fondazione Policlinico Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Rome, Italy (roberto.pallini@unicatt.it). https://orcid.org/0000-0002-4611-8827 Search for other works by this author on: Oxford Academic PubMed Google Scholar Quintino Giorgio D'Alessandris Quintino Giorgio D'Alessandris Department of Neuroscience, Catholic University School of Medicine, ItalyDepartment of Neurosurgery, Fondazione Policlinico Gemelli IRCCS, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Neuro-Oncology, noae088, https://doi.org/10.1093/neuonc/noae088 Published: 17 June 2024 Article history Corrected and typeset: 17 June 2024 Published: 17 June 2024
Microfluidic Interfaces for Chronic Bidirectional Access to the Brain
Authors: Simone Marcigaglia, Robin De Plus, Charysse Vandendriessche, Eleonore Schiltz, Marie‐Lynn Cuypers, Jordi Cools, Luis D. Hoffman, Roosmarijn E. Vandenbroucke, Maarten Dewilde, Sebastian Haesler
Journal: Advanced Healthcare Materials (2024)

Two-photon polymerization (TPP) is an additive manufacturing technique with micron-scale resolution that is rapidly gaining ground for a range of biomedical applications. TPP is particularly attractive for the creation of microscopic three-dimensional structures in biocompatible and noncytotoxic resins. Here, TPP is used to develop microfluidic interfaces which provide chronic fluidic access to the brain of preclinical research models. These microcatheters can be used for either convection-enhanced delivery (CED) or for the repeated collection of liquid biopsies. In a brain phantom, infusions with the micronozzle result in more localized distribution clouds and lower backflow compared to a control catheter. In mice, the delivery interface enables faster, more precise, and physiologically less disruptive fluid injections. A second microcatheter design enables repeated, longitudinal sampling of cerebrospinal fluid (CSF) over time periods as long as 250 days. Moreover, further in vivo studies demonstrate that the blood-CSF barrier is intact after chronic implantation of the sampling interface and that samples are suitable for downstream molecular analysis for the identification of nucleic acid- or peptide-based biomarkers. Ultimately, the versatility of this fabrication technique implies a great translational potential for simultaneous drug delivery and biomarker tracking in a range of human neurological diseases.
Multilevel Interventions Targeting Obesity: State of the Science and Future Directions
Authors: Rebecca A. Seguin-Fowler, Meredith L. Graham, Margaret Demment, Alexandra L. MacMillan Uribe, Chad D. Rethorst, Jacob Szeszulski
Journal: Annual Review of Nutrition (2024)

A seminal report, released in 2001 by the Institute of Medicine, spurred research on the design, implementation, and evaluation of multilevel interventions targeting obesity and related behaviors. By addressing social and environmental factors that support positive health behavior change, interventions that include multiple levels of influence (e.g., individual, social, structural) aim to bolster effectiveness and, ultimately, public health impact. With more than 20 years of multilevel obesity intervention research to draw from, this review was informed by published reviews ( n = 51) and identified intervention trials ( n = 103), inclusive of all ages and countries, to elucidate key learnings about the state of the science. This review provides a critical appraisal of the scientific literature related to multilevel obesity interventions and includes a description of their effectiveness on adiposity outcomes and prominent characteristics (e.g., population, setting, levels). Key objectives for future research are recommended to advance innovations to improve population health and reduce obesity.
Iron-(Fe3+) dependent reactivation of telomerase drives colorectal cancers
Authors: Raghuvaran Shanmugam, Prativa Majee, Wei Shi, Mert B. Ozturk, Thamil S. Vaiyapuri, Khaireen Idzham, Anandhkumar Raju, Seung H. Shin, Kerem Fidan, Joo-Leng Low, Joelle Y.H. Chua, Yap C. Kong, Ong Y. Qi, Emile Tan, Aik Y. Chok, Isaac Seow-En, Ian Wee, Dominique C. Macalinao, Dawn Q. Chong, Hong Y. Chang, Fiona Lee, Wei Q. Leow, Maki Murata-Hori, Zhang Xiaoqian, Chia Shumei, Chris S.H. Tan, Ramanuj Dasgupta, Iain B. Tan, Vinay Tergaonkar
Journal: Cancer Discovery (2024)

Over-consumption of iron-rich red meat and hereditary or genetic iron overload are associated with increased risk of colorectal carcinogenesis, yet the mechanistic basis of how metal-mediated signaling leads to oncogenesis remains enigmatic. Using fresh colorectal cancer (CRC) samples we identify Pirin, an iron sensor, that overcomes a rate-limiting step in oncogenesis, by re-activating the dormant human-reverse-transcriptase (hTERT) subunit of telomerase holoenzyme in an iron-(Fe3+)-dependent-manner and thereby drives CRCs. Chemical genetic screens combined with isothermal-dose response fingerprinting and mass-spectrometry identified a small molecule SP2509, that specifically inhibits Pirin-mediated hTERT reactivation in CRCs by competing with iron-(Fe3+) binding. Our findings, first to document how metal ions reactivate telomerase, provide a molecular mechanism for the well-known association between red meat, and increased incidence of CRCs. Small molecules like SP2509 represent a novel modality to target telomerase that acts as driver of 90% human cancers and is yet to be targeted in clinic.
Lateral episiotomy or no episiotomy in vacuum assisted delivery in nulliparous women (EVA): multicentre, open label, randomised controlled trial
Authors: Sandra Bergendahl, Maria Jonsson, Susanne Hesselman, Victoria Ankarcrona, Åsa Leijonhufvud, Anna-Carin Wihlbäck, Tove Wallström, Emmie Rydström, Hanna Friberg, Helena Kopp Kallner, Sophia Brismar Wendel
Journal: BMJ (2024)

To assess the effect of lateral episiotomy, compared with no episiotomy, on obstetric anal sphincter injury in nulliparous women requiring vacuum extraction.
Early Renal Dysfunction in Middle-Aged Adults Predicts Fatal and Nonfatal Cardiovascular Events
Authors: Yap-Hang Chan, Jie V. Zhao, Shiu-Lun Au Yeung, Yuen-Kwun Wong, Ka-Wing Au, Aimin Xu, Tai-Hing Lam, Bernard M.Y. Cheung, Karen Siu-Ling Lam, Hung-Fat Tse
Journal: Journal of the American College of Cardiology (2024)
10-Year Mortality After ST-Segment Elevation Myocardial Infarction Compared to the General Population
Authors: Pernille Gro Thrane, Kevin Kris Warnakula Olesen, Troels Thim, Christine Gyldenkerne, Malene Kærslund Hansen, Nina Stødkilde-Jørgensen, Lars Jakobsen, Martin Bødtker Mortensen, Steen Dalby Kristensen, Michael Maeng
Journal: Journal of the American College of Cardiology (2024)