tbuckley/cabot-search huggingface dataset:
Abstract 5755: The Role of Adhesion and Migration of Stimulated Multipotent Stromal Cell With EGF in Vasculogenesis in Type 2 Diabetes
Authors: Ali H Amin, Zakaria Y Abd Elmageed, Megan Partyka, Mohammed F Ismail, Osman Y Elazeik, Souad Belmadani, Khalid Matrougui
Journal: Circulation (2009)

Background: Chronic tissue ischemia due to defective vascular perfusion is a marker of peripheral artery disease for which minimal therapeutic options exist. Thus, type 2 diabetes is characterized with altered stem cells and vasculogenesis. Because of the capability of stem cells to differentiate into vascular cells and the importance of epidermal growth factor (EGF) in angiogenesis, their critical role in the treatment of type 2 diabetic patients with ischemia peripheral artery disease may be as prophylactic agents preventing tissue damage by stimulating vasculogenesis. Therefore we determined if multipotent stromal cells (MSC) tagged with enhanced green fluorescent protein (EGFP) stimulated with or without exogenous EGF would improve vasculogenesis in ischemia hind limb of type 2 diabetic (db−/db−) mice. Methods and Results: Isolated bone marrow from db−/db− mice showed an increase in oxidative stress and reduction in Akt compared to control. Ischemia was induced in the hind limb of db−/db− mice and control for 28 days. EGFP-MSC stimulated with or without exogenous EGF (10 ng/ml) for 24 hr were locally injected in the mice hind limb once a week for 4 weeks. After 4 weeks, blood flow measured with MoorLDI-Laser and angiogenesis assessed with X-ray were completely recovered in control mice compared to db−/db− mice. Interestingly db−/db− mice display a significant improvement of blood flow (60% and 96%) and vasculogenesis (61% and 98%) when treated with MSC or MSC pre-stimulated with exogenous EGF, respectively. Western blot analysis on hind limb muscles revealed an increase in phosphorylated Akt and VEGF receptor in db−/db− mice injected with MSC or MSC+EGF compared to non-treated db−/db− mice. Fluorescent microscopy images indicate that EGFP-MSCs differentiate into new microvessels. In vitro studies showed that adhesion and migration of MSC on cultured microvascular endothelial cells were elevated when MSC were pre-stimulated with EGF compared to non-stimulated MSC. Conclusion: Our novel data provide evidence that in type 2 diabetes, MSC stimulated with EGF are able to significantly improve, better than MSC alone, the formation of microvessels in response to ischemia.
Some differences between men and women who commit suicide
Authors: C L Rich, J E Ricketts, R C Fowler, D Young
Journal: American Journal of Psychiatry (1988)

Men have persistently had a several-fold higher suicide rate than women. In this study of 204 consecutive suicides, the authors examined three areas in which the men differed from the women. Men used more violent, immediately lethal methods of suicide, were almost three times more likely to be substance abusers, and were more likely to have economic problems as stressors. The authors conclude that while the difference in suicide rate between men and women is complexly determined, the weight of the evidence suggests that more men than women intend to commit suicide.
Informed consent and follow up in aTTom trial are inadequate
Authors: H. Cunnigham
Journal: BMJ (1996)

Table 1-Data available from trial comparng short term (five years') treatment with adjuvant tamoxifen with longer term treatment (eight years and seven months) for breast cancer.Figures are numbers of women except where otherwise stated Short term Long term treatment treatment Survival (%) 96 94 (P = 0.11) Event free survival (%) 92 86 (P = 0.016) Recurrence 10 23 Death 13 23 Cancer in contralateral breast 5 6 Second primaries 16 24unpublished data.Table 1 gives the data, which are available under the American Freedom of Information Act.Baum and Cuzick believe that the statistical analysis is highly unreliable and that the National Surgical Adjuvant Breast and Bowel Project, the National Cancer Institute and its independent
Mitral balloon valvotomy for patients with mitral stenosis in atrial fibrillation
Authors: Miltiadis N Leon, Lari C Harrell, Hector F Simosa, Nasser A Mahdi, Asad Pathan, Julio Lopez-Cuellar, Ignacio Inglessis, Pedro R Moreno, Igor F Palacios
Journal: Journal of the American College of Cardiology (1999)
Abstract 14508: Vorapaxar for Secondary Prevention after Myocardial Infarction According to Aspirin Dose - Insights from the TRA2{degrees}P-TIMI 50 Trial
Authors: Benjamin M Scirica, Marc P Bonaca, Eugene Braunwald, Amadeo Betriu, David J Moliterno, Ramon Corbalan, Sabina A Murphy, David A Morrow
Journal: Circulation (2012)

Background: In patients with a recent MI, aspirin (ASA) dose varies considerably depending on local practice patterns. Vorapaxar inhibits thrombin-mediated platelet activation by blocking the prote...
Abstract 12249: Underuse and Underdose of Oral Anticoagulants for Patients With Atrial Fibrillation in Japan: From the Fushimi Af Registry
Authors: Masaharu Akao, Hisashi Ogawa, Nobutoyo Masunaga, Moritake Iguchi, Mitsuru Ishii, Mitsuru Abe, Masahiro Esato, Yeong-Hwa Chun, Hiromichi Wada, Koji Hasegawa
Journal: Circulation (2013)

Background: Atrial fibrillation (AF) is a common arrhythmic disorder among the elderly, and is increasing significantly as the population ages (reportedly 0.6% of total population in Japan). AF inc...
Abstract 16938: Novel Oral Anticoagulants (NOAC) vs Warfarin Peri-Ablation for Atrial Fibrillation (AF): A Meta-Analysis of Embolic and Bleeding Complications
Authors: Dan L Musat, Naga Garikipati, Suneet Mittal, Aysha Arshad, Mark W Preminger, Tina Sichrovsky, Jonathan S Steinberg
Journal: Circulation (2013)

Introduction:  NOAC like dabigatran and rivaroxaban (R) are being used pre and post AF ablation. There are concerns that peri-AF ablation use of NOAC may be associated with worse outcome than warfarin (W). However, individual studies may be too small to accurately compare anticoagulation strategies given low procedural complication rates.   Methods:  We conducted a meta-analysis of all published abstracts (n=10) and papers (n=10) to date that compared complication rates for peri-AF ablation use of NOAC vs W (with or without heparin bridging). Bleeding complications included pericardial effusion, groin hematoma, GI bleeding and embolic complications included any systemic embolism. We used the Mantel-Haenszel fixed effect model for pooling the study results, with a random effects model for heterogeneous samples/results.   Results:  The 2614 pts on a NOAC (9.6% R) were similar to the 4262 pts on W. NOAC were stopped 2.5-96 hrs pre-procedure and restarted 1-48 hrs post-procedure; in 3190 (75%) W pts, W was uninterrupted. Composite bleeding rates were significantly lower in NOAC pts (4.47% vs 6.96% in W, OR 0.60, 95% CI 0.48-0.75; I2 = 47%). Composite embolic rates were similar in both groups (0.61% in NOAC vs 0.39% in W, OR 1.42, 95% CI 0.76-2.66; I2 = 0%; Figure)   Conclusions:  This meta-analysis demonstrates that NOAC are an alternative for per-AF ablation anticoagulation. They are associated with a decrease in bleeding and no significant increase in embolic events compared to W. However, given the trend for a higher embolic complication rate with NOAC,a randomized study to evaluate the two anticoagulation strategies is needed, and to determine optimal time to discontinue and resume therapy.
Abstract 2034: Clinical Significance of Sleep-disordered Breathing (SDB) in a Large Population of Japanese Patients: Efficacy of CPAP Therapy in SDB-associated Arrhythmias
Authors: Hidetoshi Abe, Matsumoto Kyoritsu, Masafumi Takahashi, Daisuke Yokota, Katsuaki Tsukioka, Jun Suzuki, Hironobu Yaegashi, Hiro Clinic, Seiichiro Eda, Hideo Tsunemoto, Mamoru Kamikozawa, Kyohei Yamazaki, Uichi Ikeda
Journal: Circulation (2007)

OBJECTIVES: The purpose of this study was to determine the relationship between Sleep-disordered breathing (SDB) and cardiovascular disorders in a large Japanese population, and to assess the efficacy of continuous positive airway pressure (CPAP) in the treatment of SDB-associated arrhythmias. BACKGROUND: SDB is associated with cardiovascular disorders, such as hypertension, ischemic heart disease, and arrhythmias, and CPAP is one of the effective treatments for SDB; however, this relationship and the efficacy of CPAP treatment in a large population of Japanese patients remain undefined. METHODS AND RESULTS: The study population comprised 1413 Japanese subjects (mean age: 56.6 years old, 1123 men and 290 women) who were divided into 2 groups: SDB group ( n = 1064, apnea-hypopnea index (AHI)≥20)and control group ( n = 349, AHI &lt; 20) by polysomnography (PSG) analysis. In baseline characteristics, age (58.3±14.7vs.50.0±18.4, p &lt;0.0001), gender (male: 88.4%vs.72.9%, p &lt;0.0001), BMI (25.9±4.4vs.23.2±3.7, p &lt;0.0001), hypertension (38.0%vs.19.3%, p &lt;0.0001), diabetes (10.4%vs.5.2%, p =0.015), or hyperlipidemia (15.6%vs.9.3%, p =0.018) were significantly associated with SDB. PSG revealed predominant occurrence of paroxysmal atrial fibrillation (PAF: 108/1064 vs. 3/349, p=0.005), premature ventricular complex (PVC: 359/1064vs.17/349, p=0.0012) and pause (sinus arrest ≥2 sec: 172/859vs.6/349, p=0.002) in SDB group. In the SDB group, 291 patients underwent CPAP titration and were then re-evaluated. CPAP therapy significantly reduced the occurrences of PAF (59/291vs.2/291, p=0.005), sinus bradycardia (18/291vs.0/291, p=0.002), and sinus pause (26/291 vs. 4/291, p=0.016). CONCLUSIONS: The results of this study provide a significant relationship between SDB and several cardiac disorders, and efficacy of CPAP in preventing SDB-associated arrhythmias in a large population of Japanese patients. Effect of CPAP on the arryhthmic events in patients with SAS during PSG recording
ECT and memory: brief pulse versus sine wave
Authors: L R Squire, J A Zouzounis
Journal: American Journal of Psychiatry (1986)

The authors evaluated the effects on memory of ECT given with either unilateral or bilateral electrode placement and with brief-pulse or sine-wave stimulus waveform. Clinical criteria determined the mode of ECT and the treatment parameters. As expected, right unilateral ECT produced less memory impairment than bilateral ECT. Brief-pulse ECT resulted in less memory impairment than sine-wave ECT during the first hour after treatment but had similar effects on memory after the first hour. Brief-pulse ECT might produce less memory impairment than conventional sine-wave ECT; however, this can probably be achieved in clinical practice only if treatment parameters that keep stimulation close to the seizure threshold are developed individually for each patient.
Abstract 917: AKT-Runx2 Signaling Regulates Oxidative Stress-induced Vascular Smooth Muscle Cell Calcification
Authors: Chang Hyun Byon, McDonald M Jay, Yabing Chen
Journal: Circulation (2007)

Oxidative stress plays a critical role in the pathogenesis of atherosclerosis, including the development of atherovascular calcification, a prominent feature of atherosclerosis. Enhanced osteogenic...
Parents' emotional neglect and overprotection according to the recollections of patients with borderline personality disorder [published erratum appears in Am J Psychiatry 1991 Sep;148(9):1282]
Authors: H Zweig-Frank, J Paris
Journal: American Journal of Psychiatry (1991)

The purpose of this study was to test clinical hypotheses about the role of emotional neglect and overprotection in the childhood of patients with borderline personality disorder.The subjects were male and female borderline (N = 62) and nonborderline (N = 99) patients from a general hospital psychiatric clinic and a university student mental health clinic. Both groups were administered the Parental Bonding Instrument, which measures subjects' recollections of parenting on dimensions of care and protection.The findings showed that the patients with borderline personality disorder remembered both their fathers and their mothers as having been significantly less caring and more controlling than did the nonborderline patients. The results were the same for male and female subjects and for subjects from both sites.The recollections provide support for psychodynamic theories about the childhood of borderline patients and for a theory of biparental failure in the development of borderline pathology.
Abstract 1662: Arrhythmic Events During the 40/90 days “Cooling Off” Period: Clinical Utility of the Wearable Defibrillator
Authors: Indrajit Choudhuri, Rozalia Tverskaya, Galina Kazanikova, Jason A Gluck, Seth I Keller, Ranjit Suri
Journal: Circulation (2007)

Background: A “cooling off” period (COP) of 40 days after MI and 90 days after coronary revascularization or non-ischemic CM (NICM) diagnosis is customary to allow clinical improvement prior to assessing the need for ICD implantation. The COP creates a clinical dilemma that requires balancing ongoing sudden death (SD) risk and the cost of potentially unnecessary ICD implants. We reviewed our wearable defibrillator (WD) experience to assess its clinical utility during this period of uncertainty. Methods: Medical records from 27 patients with EF≤35% requiring a COP who were offered WD (LifeVest, ZOLL Lifecor) were reviewed for clinical indication, EF before and after WD use, sudden cardiac arrest (SCA) or treated VT/VF, and subsequent outcome. Results: Wearable defibrillator indications were: recent MI (n=7), ischemic CM (ICM) with recent revascularization (n=10), untreated NICM (n=9), and tachycardia-CM (n=1). Twenty-five of 27 patients agreed to WD and 23 complied. Two patients had 3 clinical events: 1 (not wearing WD) was resuscitated from SCA; 1 (treated by WD) survived sustained syncopal VT/VF but later died suddenly not wearing the WD. One patient was shocked for AF. After the COP (n=24), 6/24 (25%) patients had EF&gt;35% (3 ICM and 3 NICM) and no ICD was implanted. Eighteen of 24 (75%) had an EF ≤ 35% and received an ICD. Three of 24 (12.5%) patients that received an ICD ultimately had an EF ≥35% over continued follow-up. Conclusions: During the COP, patients with EF ≤ 35% had a 12% clinical event rate (3 events in 25 patients). WD protected patients during this high-risk period but non-adherence was associated with death/cardiac arrest. While ICD implantation was safely avoided in 25%, unnecessary ICD implantation still occurred. Prolonged WD therapy beyond the COP may be more prudent in some to observe for delayed recovery (12%). In patients with newly diagnosed LV systolic dysfunction or after revascularization, risk and recovery are in flux. We suggest that this continuum is not confined to the COP. In patients with low EF, prolonged application of WD may provide additional SD prevention beyond the initial high-risk period and may prevent unnecessary ICD implantation.
Resignation of US judge puts reproductive rights at risk
Authors: Janice Hopkins Tanne
Journal: BMJ (2005)

Justice Sandra Day O'Connor has announced her resignation but will stay until a replacement is found. It will be a disputatious summer in Washington, DC, as President George Bush searches for a nomination to fill the Supreme Court seat that she vacates.

The choice of Justice O'Connor's successor is seen as crucial to both the conservative right and to liberals and women's groups because it will affect the future composition of the court. Justice O'Connor is a centrist, who has voted with both liberal and conservative members of the nine member court in “swing vote” five to four decisions. She has been the deciding vote in decisions in favour of abortion rights, civil rights, environmental issues, affirmative action, voting rights, and the government's neutrality toward religion.

Abortion was legalised by the …
Cyclin D1 Expression in Mantle Cell Lymphoma Is Accompanied by Downregulation of Cyclin D3 and Is Not Related to the Proliferative Activity
Authors: M. Michaela Ott, Jirina Bartkova, Jiri Bartek, Alexander Dürr, Lars Fischer, German Ott, Hans Konrad Müller-Hermelink, Hans Kreipe
Journal: Blood (1997)
TV: Prime time torture
Authors: K. Sherlock, B. Ayotte
Journal: BMJ (1999)

For the first time in the history of television drama, a prime time series is focusing on the issue of torture. The popular US series ER is currently airing a recurring storyline that centres on two survivors of torture from Nigeria who resettle in Chicago and begin working at the city hospital. (The first episode of the story is transmitted on British television next week on 28 April). The US based group Physicians for Human Rights suggested the storyline and assisted the producers and cast with the script.



ER's Dr Green discovers that Mobalage has been tortured



The story begins with Dr Mark Green noticing a janitor named Mobalage wincing with back pain as he works. He is resistant to Green's offer to examine his back but, as Green continues to show concern, finally agrees to the examination. When placed in the examination room he becomes claustrophobic, ripping the curtain down in a rage. As Green lifts Mobalage's shirt, an array of keloids are revealed (probably the result of burns). Mobalage also complains of erectile dysfunction and asks for the drug Viagra. Green orders some urological tests and ultimately recommends surgery. Mobalage's wife, Kubby, chases Green, expressing fear …
Abstract 1321: African Americans Have Worse Arterial Compliance Than Whites, Independent of Risk Factor Burden and Framingham Risk Estimates
Authors: Riyaz S Patel, Alanna Morris, Yusuf Ahmed, Neli Stoyanova, Ibhar Al Mheid, Nino Kavtaradze, Dorothy Coverson, Liping Zhao, Aurelian Bidulescu, Zhimin Chen, Kenneth L Brigham, Rebecca Din-Dzietham, Viola Vaccarino, R. Wayne Alexande, Gary Gibbons, Arshed A Quyyumi
Journal: Circulation (2009)
Abstract 2279: Fibroblasts Are Essential for the Generation of Embryonic Stem Cell Derived Bioengineered Myocardium
Authors: Peter Christalla, Michael Didie, Thomas Eschenhagen, Magdalini Tozakidou, Heimo Ehmke, Wolfram-Hubertus Zimmermann
Journal: Circulation (2009)

The heart is mainly composed of non-myocytes (NMs; ~70%). Here we used a novel in vitro model of heart muscle development, namely engineered heart tissue (EHT) to test the hypothesis that NMs are e...
Abstract 12148: CXCR4 Mediated Bone Marrow Progenitor Cell Maintenance and Mobilization are Modulated by c-kit Activity
Authors: Min Cheng, Junlan Zhou, Min Wu, Qiutang Zeng, Raj Kishore, Douglas Losordo, Gangjian Qin
Journal: Circulation (2010)

Rationale: The mobilization of bone-marrow (BM) progenitor cells (PCs) is largely governed by interactions between stromal-cell derived factor 1 (SDF-1) and CXC-chemokine receptor 4 (CXCR4). Ischemic injury disrupts the SDF-1-CXCR4 interaction and releases BM PCs into the peripheral circulation, where the mobilized cells are recruited to the injured tissue and contribute to vessel growth. BM PCs can also be mobilized by the pharmacological CXCR4 antagonist AMD3100, but the other components of the SDF-1-CXCR4 signaling pathway are largely unknown. c-kit, a membrane bound tyrosine-kinase and the receptor for stem cell factor, has also been shown to play a critical role in BM PC mobilization and ischemic tissue repair. Objective: To investigate the functional interaction between SDF-1-CXCR4 signaling and the c-kit activity in BM PC mobilization. Methods and Results: AMD3100 administration failed to mobilize BM PCs in mice defective in c-kit kinase activity or in mice transplanted with BM cells that expressed...
Abstract 2281: Mitral E Wave Deceleration Time to Peak E Velocity Ratio And Cardiovascular Outcome in Hypertensive Patients During Anti-Hypertensive Treatment: the LIFE Echo-Substudy.
Authors: Marcello Chinali, Rakesh K Mishra, Giovanni de Simone, Gerard P Aurigemma, Eva Gerdts, Kristian Wachtell, Kurt Boman, Bjorn Dahlof, Richard B Devereux
Journal: Circulation (2007)

Background: Early mitral flow deceleration time (DTE) is a prognostically validated marker of LV chamber stiffness. However, for any given LV stiffness, a higher E peak velocity (E) is associated with longer DTE, suggesting that the prognostic relevance of DTE might be influenced by variations in cardiac preload (e.g. during anti-hypertensive treatment). It is not known whether normalization of deceleration time for E-velocity (DTE/E) might be a more stable diastolic index for prediction of incident cardiovascular (CV) events in hypertensive patients during treatment, as compared to DTE. Methods: We evaluated 770 hypertensive patients (66±7 years; 42% women) with ECG-LV hypertrophy enrolled in the LIFE echo-substudy. Echocardiographic exams were performed annually for 5 years during anti-hypertensive treatment. Prognostic value of basal DTE/E was preliminary evaluated. Variation over time of both DTE/E and DTE were therefore analyzed in relation to incident combined fatal and non-fatal CV events. Results: During follow-up, 69 CV events occurred (9% of study population). Mean basal DTE/pE was 3.55±1.55 sec 2 /cm*10 −3. In univariate analysis baseline DTE/E was associated positively with age (r=0.10; p&lt;0.01), relative wall thickness (r=0.13; p&lt;0.01) and isovolumic relaxation time (r=0.26; p&lt;0.001) and negatively with heart rate (r=−0.20; p&lt;0.001); no association was found with systolic blood pressure, diastolic blood pressure, LV mass or ejection fraction. Unadjusted Cox regression showed a positive association between baseline DTE/E and CV events [(HR=1.21 (95%CI= 1.07–1.37); p=0.002]. In time-varying Cox model, independently of age, gender, type of anti-hypertensive treatment and in-treatment heart rate, higher in-treatment DTE/E was associated with higher rate of CV events [(HR=1.26 (95%CI= 1.04 –1.80); p&lt;0.026], whereas no association was found for in-treatment DTE (p=NS). Conclusions: In a population of treated hypertensive patients with ECG-LV hypertrophy, the ratio of in-treatment DTE/E, but not DTE alone, independently predicts incident CV events. In high-risk hypertensive patients, normalization of DTE for E peak velocity might be preferred to DTE in evaluating diastolic function during anti-hypertensive treatment.
Abstract 15966: Impact of Sustained Anemia on Long Term Clinical Outcomes in Patients Who Underwent Drug-Eluting Stent
Authors: Tae-Hoon Kim, Ki-Bae Seung, Yoon-Seok Koh, Eun Ho Choo, Soe Hee Ann, Jeong-Eun Yi, Jung Yeon Chin, Tae-Seok Kim, Hun Jun Park, Kiyuk Chang, Sang Hyun Ihm, Jong Min Lee
Journal: Circulation (2011)

Introduction: Only a few studies presented concerning anemia because of its association with myocardial ischemia, and demonstrated that anemia is an independent predictor of high 30-day major adver...
Abstract 20290: Spectrum and Contribution of Mutations in Minor Long QT Syndrome (LQTS)-Susceptibility Genes in Patients Referred for FAMILION(R) LQTS Genetic Testing
Authors: Thomas E Callis, Benjamin A Salisbury, Carole Harris-Kerr, Magda Smielewska-Antov, Argelia Medeiros-Domingo, David J Tester, Michael J Ackerman
Journal: Circulation (2010)

Background: Inherited long QT syndrome (LQTS) is a potentially lethal arrhythmogenic syndrome marked by significant genetic heterogeneity. In recent years, several new genetic substrates for LQTS h...
Abstract 985: Renin-Angiotensin System (RAS) Blockade Ameliorates Diuretic Induced Hyperglycemia in Obese Hypertensive Normoglycemic or Prediabetic Individuals
Authors: Prakash C Deedwania, James R Sowers, Ishwarlal Jialal, Brent M Egan, Leopoldo Raij, Das Purkayastha, Rita Samuel, Dion Zappe
Journal: Circulation (2009)
Endovascular Repair of Ascending Aortic Dissection
Authors: Qingsheng Lu, Jiaxuan Feng, Jian Zhou, Zhiqing Zhao, Junmin Bao, Rui Feng, Liangxi Yuan, Xiang Feng, Lefeng Qu, Yifei Pei, Zhijun Mei, Zaiping Jing
Journal: Journal of the American College of Cardiology (2012)