tbuckley/cabot-search huggingface dataset:
Preliminary data from a multicenter Italian study: use of EUS-Elastography and Contrast in the differential diagnosis of SELs
Authors: M. Terrin, A. Facciorusso, M. Colombo, K. Khalaf, E. Maldi, F. M. Nicolosi, A. Fantin, T. Staiano, M. Gruppo, G. Donato, M. Spadaccini, M. Andreozzi, R. E. Rossi, D. Rahal, S. L. Renne, F.C. M. Cananzi, A. F. Bertuzzi, A. Fugazza, A. Repici, S. Carrara
Journal: Endoscopy (2024)

Aims Distinguishing gastrointestinal subepithelial lesions (GI-SELs) poses a clinical challenge because Endoscopic Ultrasound (EUS) is adept at detecting them but may fall short in providing effective differentiation. New methodologies have been introduced which provide further details and potential prognostic information. Elastography (EUS-E) allows to carry out a qualitative and semi-quantitative assessment of tissue stiffness, but for now only a few studies have examined its role in the diagnosis of SELs. Recent findings indicate that contrast agents enhance the diagnostic accuracy of EUS (CE-EUS) for SELs. The purpose of the study is to examine the performance of the EUS-E and CE-EUS in differentiating GI-SELs, and in particular gastrointestinal stromal tumors (GISTs).
Prediction of Lymph Node Metastasis from Whole Slide Pathology Images of Early Gastric Cancer using a 2 step Machine Learning Approach
Authors: B. Lee, B. Keum, S. Ahn, H. J. Jeon, S. Kim, Y. T. Jeen, H. J. Chun
Journal: Endoscopy (2024)

Aims In Early Gastric Cancer(EGC), if the risk of lymph node metastasis(LNM) is negligible, endoscopic curative resection is performed preferentially. If LNM is suspicious, additional gastrectomy with lymphadenectomy should be performed.
Impact of EUS-guided choledochoduodenostomy versus transpapillary endoscopic biliary drainage on the intra- and post-operative outcome of pancreatoduodenectomy: a multicenter propensity score matched study
Authors: J. A. Fritzsche, M. J. De Jong, B. A. Bonsing, O. Busch, F. Daams, F. Van Delft, W. J. Derksen, J. I. Erdmann, S. Festen, P. Fockens, E. M. Van Geenen, A. Inderson, G. Kazemier, S. D. Kuiken, M. S. Liem, D. J. Lips, W. Te Riele, H. Van Santvoort, P. D. Siersema, N. G. Venneman, R. Verdonk, F. Vleggaar, M. Besselink, R.L J van Wanrooij, R. P. Voermans
Journal: Endoscopy (2024)

Aims Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) with lumen-apposing metal stents (LAMS) may be used in patients with a distal malignant biliary obstruction in whom either conventional biliary drainage by endoscopic retrograde cholangiopancreatography (ERCP) failed or as primary drainage approach in research setting. [1] [2] Although EUS-CDS has shown promising results, experience with EUS-CDS prior to pancreatoduodenectomy (PD) is still limited. [2] [3] [4] [5] [6] Therefore, in daily clinical practice multidisciplinary teams are reluctant to opt for EUS-CDS in patients with potentially resectable tumors. Aim of this study was to assess the impact of EUS-CDS on the intra- and post-operative outcome of PD when compared with transpapillary drainage.
First Clinical Application of a Novel Duodenal Mucosal Ablation Device for Type 2 Diabetes Using Radiofrequency Vapor Ablation: A Video-Case
Authors: A. Papaefthymiou, N. Benjamin, P. Hoebel, L. Grunert, R. Haidry
Journal: Endoscopy (2024)

Abstract Text Duodenal mucosal ablation is an emerging endoscopic technique in the management of metabolic disease, providing promising results for type 2 diabetes (T2D) control. A novel through the scope (TTS) ablation device, the circumferential radiofrequency (RF) vapor ablation system (Aqua Medical, California, USA) is currently under evaluation in a first in human clinical trial. We present a patient with poorly controlled T2D, who underwent the procedure using a double-channel upper endoscope. This new circumferential RF vapor ablation system for duodenal ablation adds another promising intervention for T2D. Results from the first-in-human STEAM T2D trial will inform overall safety and efficacy.
EUS-guided Fine-Needle Biopsy for Diagnosis and Molecular Profiling of Extrahepatic Cholangiocarcinoma: a Single-Center Retrospective Study
Authors: E. Troncone, F. Gadaleta, L. Savino, R. Amendola, A. Moscardelli, P. Santangelo, E. De Cristofaro, P. De Vico, G. Monteleone, G. Del Vecchio Blanco
Journal: Endoscopy (2024)

Aims The most common cause of biliary stricture is malignancy, but histological confirmation is mandatory before performing invasive surgical interventions or chemotherapy. Moreover, the increasing use of targeted anti-cancer therapies based on tumor molecular profiling makes the quality of the sampling of the neoplastic tissue even more important. In this study, we aimed to investigate the performance of endoscopic ultrasound (EUS) guided fine-needle biopsy (FNB) in diagnosis of extra-hepatic biliary strictures. Additionally, we evaluated the adequacy of the tissue sample for molecular biology analysis.
Successful management of a full-thickness muscularis propria defect with an omental patch after endoscopic resection of an 50 mm gastric GIST
Authors: M. E. Argenziano, S. Smeets, L. Debels, P. J. Poortmans, M. Montori, S. Ridolfo, T. Tornai, L. Desomer, D. J. Tate
Journal: Endoscopy (2024)

Abstract Text A 69 year old female received an upper GI endoscopy; a 50 mm, submucosal, ulcerated, bulky, lesion was found in the gastric body. CT scan confirmed a gastric GIST without loco-regional lymph nodes or metastasis. Submucosal Tunnelling Endoscopic Resection (STER) was attempted but due to the ulceration completion was not feasible. During tunnelling, tumour involvement of the muscularis propria was revealed. The dissection was completed from the muscularis resulting in a large full-thickness defect of the gastric wall. Due to the size of the defect closure was difficult and successfully achieved with an omental patch fixed with through the scope endoscopic clips. Histopathology confirmed the GIST (pT2NX, mitotic index of 4 per 5 mm²). MDT discussion agreed to follow-up. No additional treatment was deemed necessary. 6 months radiologic, endoscopic and histologic follow-up was negative.
Double guide-wire technique versus transpancreatic biliary sphincterotomy for difficult biliary cannulation: a randomized controlled trial
Authors: K. Amalou, F. Belghanem, M. Medkour
Journal: Endoscopy (2024)

Aims During endoscopic retrograde cholangiopancreatography (ERCP) for biliary indication, difficult biliary cannulation with an unintended access to the main pancreatic duct (PD) increases the risk of post-ERCP pancreatitis (PEP). Both double guidewire technique (DGW) and transpancreatic biliary sphincterotomy (TPBS) can be performed. The purpose of this prospective, randomized, controlled trial is to compare the technical success and adverse events (AEs) rate of these techniques.
The Hybrid-APC study: initial results of a Multicenter Observational Study on Barrett Esophagus treatment
Authors: R. Maselli, D. Massimi, A. Capogreco, A. Galtieri, R. Nicoletti, A. D'aprano, R. de Sire, M. Menini, F. Coppola, M. A. La Terra, G. Andrisani, F. M. Di Matteo, S. Pecere, S. Cristiano, C. Hassan, A. Repici
Journal: Endoscopy (2024)

Aims Preliminary data from a prospective, single-arm, multicenter observational study to evaluate the initial treatment success of the Hybrid-APC (H-APC) technique, which combines argon plasma coagulation (APC) with a previous saline injection for ablation therapy of neoplastic Barrett's esophagus (BE). This technique is being evaluated as an alternative to radiofrequency (RFA), the current gold standard.
EUS-guided choledochoduodenostomy for primary drainage of malignant distal biliary obstruction (SCORPION-II-p): a prospective pilot study using FCSEMS through LAMS
Authors: J. A. Fritzsche, P. Fockens, M. Besselink, O. Busch, F. Daams, J. Wilmink, R. P. Voermans, R.L J van Wanrooij
Journal: Endoscopy (2024)

Aims EUS-guided choledochoduodenostomy (EUS-CDS) with a lumen-apposing metal stent (LAMS) is an alternative for ERCP in patients with a malignant distal biliary obstruction (MBO). [1] [2] The main drawback of EUS-CDS using LAMS is the high rate of stent dysfunction which leads to cholangitis and reinterventions. [3] [4] Presumably, the short length and perpendicular angle of the LAMS to the bile duct contribute to the risk of stent dysfunction. [5] Therefore, the aim was to investigate whether placement of a fully covered self-expandable metal stent (FCSEMS) through the LAMS, thereby changing the axis of biliary drainage towards the descending duodenum, will decrease the risk of stent dysfunction while maintaining high technical success and low adverse event rates.
Endoscopic Management of Retrorectal Cystic Hamartoma
Authors: O. Kiosov, V. Tkachov, S. Gulevskyi
Journal: Endoscopy (2024)

Abstract Text An extremely rare retrorectal cystic hamartoma, linked to embryonic hindgut remnants, often benign and asymptomatic, primarily affects middle-aged women. Complications involve infections causing fistulas and potential malignancy. Complete surgical removal is advised due to these risks. We detail a successful endoscopic approach for a forty-five year old woman with a 2cm retrorectal tumor, incidentally found on CT, devoid of symptoms or familial gastrointestinal history. Endoscopy revealed a smooth bulge on the rectal wall. Endoscopic ultrasound depicted a 25x13mm oval tumor near the rectal wall. Considering its location and characteristics, retrorectal extraluminal endoscopic resection was performed in STER-like manner under general anesthesia. Histology confirmed a cystic hamartoma (tailgut cyst). This case highlights the first example of effective endoscopic management for such lesions. [1] [2] [3]
Impact of temperature-controlled endobiliary radiofrequency ablation on biliary drainage in patients with inoperable hilar cholangiocarcinoma: A propensity score–matched analysis
Authors: I. S. Shin, J. H. Moon, Y. N. Lee, J. H. Myeong, J. W. Park, J. W. Park, T. H. Lee, J. K. Yang, Y. D. Cho, S. H. Park
Journal: Endoscopy (2024)

Aims Few studies have evaluated outcomes of endobiliary radiofrequency ablation (RFA) for malignant obstruction in the hilar bile duct, which has a thin wall and complex duct–vascular contacts. We evaluated the efficacy and safety of temperature-controlled endobiliary RFA, which can reduce the risk of unintentional thermal injury, in the treatment of inoperable hilar cholangiocarcinoma (CCA).
EUS- versus ERCP-guided biliary drainage for malignant biliary obstruction: a systematic review and meta-analysis of randomized controlled trials
Authors: E. Barbosa, P. Santo, S. Baraldo, A. Nau, G. Meine
Journal: Endoscopy (2024)

Aims This systematic review and meta-analysis aimed to compare the efficacy and safety of endoscopic ultrasound-guided biliary drainage (EUS-BD) and endoscopic retrograde cholangiopancreatography-guided biliary drainage (ERCP-BD) as the initial approach for malignant biliary obstruction (MBO).
Only half of the patients treated endoscopically for early Barrett related neoplasia is detected during Barrett surveillance
Authors: L. Boer, L. Alvarez Herrero, A. Alkhalaf, B. Schenk, E. Schoon, W. Curvers, A. Koch, P.J. F. De Jonge, W. B. Nagengast, J. Westerhof, M.H.M. G. Houben, J. Bergman, R. Pouw, L.A. A. Brosens, B.L.A. M. Weusten, S. N. Van Munster
Journal: Endoscopy (2024)

Aims Barrett's esophagus (BE) with early neoplasia is an indication for endoscopic treatment. Patients with non-dysplastic BE are typically enrolled in an endoscopic surveillance program to enable early detection, and treatment, of BE related neoplasia. In contrast, a subset of patients with early BE neoplasia is concurrently diagnosed with BE and early neoplasia. Our goal was to distinguish cases detected through endoscopic surveillance programs (i.e. initial detection of non-dysplastic BE with progression to neoplasia later in time (metachronous neoplasia)) from cases where BE and neoplasia were diagnosed simultaneously (synchronous neoplasia).
Which scoring systems are useful for predicting the prognosis of LGI bleeding? Old and New
Authors: H. S. Moon
Journal: Endoscopy (2024)

Aims Lower gastrointestinal (GI) bleeding can be fatal and a common indication for hospital admission. Therefore, several scoring systems have been developed to predict its prognosis. Rockall score (RS), Glasgow-Blatchford score (GBS), and AIMS65 score are frequently used for lower GI bleeding assessments. Recently, ABC score, Oakland score, SHA2PE score, CHAMPS score were developed, for predicting mortality rates and hospitalizations of lower GI bleeding. We compared the mortality predictions and prolonged hospital stay (≥10days) of these various scoring systems.
Endoscopic ultrasound-guided hepaticogastrostomy versus percutaneous transhepatic biliary drainage as a salvage therapy in patients with malignant biliary obstruction
Authors: E. Ghoneem, A. Mahgoub, T. Sheta, O. Shiha, M. Ebrahim
Journal: Endoscopy (2024)

Aims The current prospective study aims to assess the safety and efficacy of EUS guided -Hepaticogastrostomy (HGS) compared to Percutaneous transhepatic biliary drainage (PTBD) in this setting.
Safety, technical efficacy and long-term clinical outcomes of endoscopic therapy for foregut Neuroendocrine Tumors (NETs)
Authors: R. Yewale, A. A. Pagadapelli, A. Bale, M. Borkar, S. Korrapati, A. Bapaye
Journal: Endoscopy (2024)

Aims Early, localized neuroendocrine tumors (NETs) arising from foregut (stomach/duodenum/ampullary) are amenable to endoscopic treatment due to low frequency of lymph node and distant metastases. Dearth of literature on technical feasibility, safety and long-term outcomes of endoscopic resection modalities limits widespread adoption of endo-therapy for foregut NETs. Our objective was to outline the technical challenges and long-term clinical outcomes of endo-therapy for foregut NETs.
Optimal timing for a second ERCP after failure of initial biliary cannulation following precut sphincterotomy in difficult biliary cannulation: a randomized clinical trial
Authors: K. Amalou, F. Belghanem, M. Medkour
Journal: Endoscopy (2024)

Aims Precut sphincterotomy is a technique usually employed for difficult biliary cannulation during endoscopic retrograde cholangiopancreatography (ERCP), it increases the success of deep biliary cannulation, but the method fails at the initial ERCP in 5-12% of cases. Although other invasive strategies are often used to access the bile duct, a second ERCP may be effective and safe. We evaluated the efficacy, safety, and factors related to a second ERCP after failed cannulation using a precut sphincterotomy.
Comparison of the efficacy and safety of endoscopic management of fistulas after bariatric surgery with the Luso-Cor and conventional covered metallic stents
Authors: I. Coelho Rodrigues, C. N. Ferreira, C. Freitas, M. Moura, I. Seves, R. Freire, P. Russo, M. S. Santos, E. Barjas, L. Glória, J. Lopes, A. Marques, L. Carrilho-Ribeiro, R. Marinho, L. Correia
Journal: Endoscopy (2024)

Aims Fistulas after bariatric surgery may develop in upto 4.9% patients. A primarily endoscopic approach to manage these fistulas is successful in 2/3 of patients but is burdensome. The Luso-Cor(R) esophagealstent (LCES) was designed to manage fistulas and strictures while taking into account the altered anatomy after bariatric and gastric oncologic surgery. We aimed to compare the efficacy and safety of management of post bariatric surgery fistulas with the LCES and other metallic covered stents (CS).
Endoscopic Ampullectomy: a multi-centred study of tertiary centres across the United Kingdom
Authors: E. Lim, J. Leeds
Journal: Endoscopy (2024)

Aims Ampullary tumours are becoming more prevalent with increasing modalities of imaging and endoscopies. Resection of ampullary adenomas are mandatory given the potential for malignancy. A recent systematic review has shown endoscopic ampullectomies complication rate of 24.7% and a recurrence rate of 13%. Our aim was to review the practice in multi-centred pancreato-biliary units across the United Kingdom to identify techniques, risks profile and recurrence.
Successful endoscopic management of a juxta-pyloric lumen obstructing Lipoma using Endoscopic submucosal dissection (ESD)
Authors: A. Gandhi, H. Jain, V. Kahalekar, U. Takalkar, B. Takle, U. Kulkarni, P. Apsingekar, J. Tekale, V. Daunde, A. Bapaye
Journal: Endoscopy (2024)

Abstract Text 70-y-female – recurrent vomiting episodes post meals; Comorbidities–Obesity, COPD, DM, HTN. EGD – 2 'kissing' lesions – 1 epithelial (15mm, sessile, JNET 2A, posterior antral wall) & 1 sub-epithelial (30mm, pseudo-pedunculated, juxta-pyloric/anterior antral wall); additionally, SEL – ball valve effect on pyloric ring & prolapse into D1. Posterior wall polyp – underwent EMR(HPE – Adenoma). Juxta-pyloric SEL – underwent ESD. Procedure–supine,GA, prolapsed SEL repositioned from D1 into antrum; submucosal injection f/b pocket dissection–muscle and mucosal side–en bloc (30mm size) retrieval – hemostasis – incision closure using clips. Post ESD – no complications; Procedure duration – 70min. Clinical recovery – Oral diet resumed on day 1. Discharged after 48 hours. HPE – Lipoma. F/u at 4-wk – asymptomatic. EGD at 4-wk – healed incision site, no GI obstruction.
Endoscopic ultrasound guided choledocoduodenostomy (CD) versus hepaticogastrostomies (HG) in distal malignant biliary obstruction: is it only a matter of expertise?
Authors: J. M. Gonzalez, T. Heusse, R. Legros, M. Gasmi, J. Albouys, M. Barthet, J. Jacques
Journal: Endoscopy (2024)

Aims Endoscopic retrograde drainage remains the first line treatment in distal malignant biliary obstructions (DMBO). However, recent series increasingly evaluate and propose EUS-CD as serious alternative, particularly in center with limited experience in EUS-HG. Indeed, randomized study demonstrated equivalent clinical efficacy and safety between ERCP and EUS-CD, without the risk of acute pancreatitis. However, in the case of duodenal stenosis, CD dysfunctions were observed, and EUS-HG seems the best option, but requires a higher level of expertise. We conducted this study to evaluate these two techniques in two centers with different level of expertise in EUS-HG.
Transstomal EUS-guided ileocolostomy for relief of malignant small-bowel obstruction
Authors: G. Vanella, P. Biamonte, G. Di Cosmo, L. Archibugi, M. Tacelli, E. Ortolano, P. Arcidiacono
Journal: Endoscopy (2024)

Abstract Text A 53-years-old man with bladder carcinoma underwent radical cystectomy in 2018 and Hartman's procedure with left colostomy in 2022 due to recurrent disease. He was admitted in 2023 for complete intestinal obstruction. The patient was deemed unfit for surgery, hence endoscopic recanalization was proposed as an alternative. Thus, the cecum was reached using a standard colonoscope and a guidewire was released as a reference. The echoendoscope was therefore advanced via the colostomy up to the cecum, using fluoroscopy and the guidewire. Under endosonographic view, a dilated loop with buildup of intestinal material was immediately visible and a ileocolonic anastomosis was performed with fecal material backflow upon LAMS release.
High sensitivity of biliary brush cytology after optimization of protocol in patients with suspected perihilar or intrahepatic cholangiocarcinoma: a prospective cohort study with historical control
Authors: J. A. Fritzsche, E. Smit, O. Van Delden, F. Dijk, J. I. Erdmann, P. Fockens, A. Farina Sarasqueta, G. Kazemier, H. J. Klümpen, S. L. Meijer, C. Y. Ponsioen, A. M. Uyterlinde, R.L J van Wanrooij, M. C. Wielenga, I. A. Zijlstra, J. Verheij, R. P. Voermans
Journal: Endoscopy (2024)

Aims Endoscopic or percutaneous bile duct brushing is often performed as first step to differentiate between benign and malignant biliary strictures. Although brush cytology has a high specificity (95-100%), the sensitivity for detection of malignancy has been reported to be poor (41-67%) (1-4). This results in repeated diagnostic procedures with potential treatment delay, adverse events, and additional costs. Aim of this study was to evaluate a change in protocol with optimization of obtaining, handling and rating of brush cytology in patients with suspected perihilar or intrahepatic cholangiocarcinoma (pCCA/iCCA).
Clinical, histological and endoscopical characterization in patients with ischemic colitis. A case series
Authors: J. Garcia, J. Rodriguez, E. Rodriguez, E. Suarez Zambrano, C. Suárez Montesdeoca, P. Moreno, P. Borque Barrera, F. A. Perez
Journal: Endoscopy (2024)

Aims Ischemic colitis (IC) is a frequent colonic vascular disorder due to an imbalance in the colonic tissue between the oxygen intake and the oxygen need. Incidence is increasing because of the rise of cardiovascular risk factors prevalence and the ageing population.
Differential Diagnosis between Crohn&amp;apos;s Disease and Intestinal Tuberculosis Using an Artificial Intelligence Algorithm
Authors: J. S. Byeon, K. Park, J. Lim, N. Kim
Journal: Endoscopy (2024)

Aims Differential diagnosis between Crohn's disease (CD) and intestinal tuberculosis (ITB) is challenging. This study aimed to investigate the potential for employing a convolutional neural network (CNN)-based model, utilizing colonoscopy images, to facilitate the differential diagnosis between CD and ITB.
Artificial Intelligence for Automatic Diagnosis and Pleomorphic Morphologic Characterization of Malignant Biliary Strictures Using Digital Cholangioscopy: A Multicentric Transatlantic Study
Authors: M. González-Haba Ruiz, M. Mascarenhas, J. Widmer, B. Agudo, T. Ribeiro, J. P. Afonso, M. Francisco, M. Martins, C. Pedro, F. Vilas Boas, J. Ferreira, M. Guilherme
Journal: Endoscopy (2024)

Aims Despite the advances of recent years, the diagnosis and characterization of biliary strictures is challenging. Artificial intelligence applied to digital single-operator cholangioscopy (D-SOC) is expected to provide a significant increase in the diagnostic yield of indeterminate biliary strictures. Pilot studies using artificial intelligence (AI) algorithms applied to D-SOC have shown promising results. This multicentric study aimed to validate a CNN model on a large dataset of D-SOC images, providing automatic detection of malignant biliary strictures, as well as their morphological characterization
Electrochemical in-situ intraoperative testing during ERCP for safer cannulation: A Novel Approach Using Multi-Pole Electrodes and Electrochemical Impedance Spectroscopy
Authors: T. Khoury, S. Abboud, R. Shlewet, W. Sbeit
Journal: Endoscopy (2024)

Aims Inadvertent pancreatic duct cannulation is a common unwanted event during ERCP procedures that may increase the rates of complications. This study introduces a novel method for guiding ERCP navigation by employing multi-polar electrodes to measure the electrical properties of bile and pancreatic juices through Electrochemical Impedance Spectroscopy (EIS). The method is intended for use during ERCP to alert the user about pancreatic duct proximity and help in directing the position of the sphincterotome for selective biliary canulation
Endoscopic Sleeve Gastroplasty: can we predict its efficacy at an early stage?
Authors: M. V. Matteo, V. Bove, G. Ciasca, G. Carlino, V. Pontecorvi, M. De Siena, R. Di Santo, L. Gualtieri, G. Giannetti, M. Angeletti, N. Antonini, C. Massari, C. Chiarini, M. Papi, C. Spada, I. Boskoski
Journal: Endoscopy (2024)

Aims Obesity is a complex multifactorial disease requiring a multidisciplinary approach. Endoscopic Sleeve Gastroplasty (ESG) is an effective, minimally invasive bariatric procedure for the treatment of obesity. However, not all subjects achieve the same results. Factors related to better outcomes after ESG are poorly understood. According to the literature, the efficacy threshold for a "primary" bariatric procedure is a%EWL of 25% at 12 months. Identifying baseline and early predictors of success may improve weight loss outcomes through a smart selection of patients as well as the identification of poor responders who may need additional treatment. This study aims to investigate the presence of any baseline or early indicators of long-term favourable or unfavourable responses to ESG.