tbuckley/cabot-search huggingface dataset:
Clinical, Histologic, and Transcriptomic Evaluation of Sequential Fat Grafting for Morphea
Authors: Juzi Liu, Jing Wang, Qian Zhang, Feng Lu, Junrong Cai
Journal: JAMA Dermatology (2024)

Importance Morphea is a rare disease of unknown etiology without satisfactory treatment for skin sclerosis and soft tissue atrophy. Objective To provide clinical, histologic, and transcriptome evidence of the antisclerotic and regenerative effects of sequential fat grafting with fresh fat and cryopreserved stromal vascular fraction gel (SVF gel) for morphea. Design, Setting, and Participants This single-center, nonrandomized controlled trial was conducted between January 2022 and March 2023 in the Department of Plastic and Reconstructive Surgery of Nanfang Hospital, Southern Medical University and included adult participants with early-onset or late-onset morphea who presented with varying degrees of skin sclerosis and soft tissue defect. Interventions Group 1 received sequential grafting of fresh fat and cryopreserved SVF gel (at 1 and 2 months postoperation). Group 2 received single autologous fat grafting. All patients were included in a 12-month follow-up. Main Outcome and Measures The primary outcome included changes in the modified Localized Scleroderma Skin Severity Index (mLoSSI) and Localized Scleroderma Skin Damage Index (LoSDI) scores as evaluated by 2 independent blinded dermatologists. The histologic and transcriptome changes of morphea skin lesions were also evaluated. Results Of 44 patients (median [IQR] age, 26 [23-33] years; 36 women [81.8%]) enrolled, 24 (54.5%) were assigned to group 1 and 20 (45.5%) to group 2. No serious adverse events were noted. The mean (SD) mLoSSI scores at 12 months showed a 1.6 (1.50) decrease in group 1 and 0.9 (1.46) in group 2 ( P = .13), whereas the mean (SD) LoSDI scores at 12 months showed a 4.3 (1.34) decrease in group 1 and 2.1 (1.07) in group 2 ( P &amp;amp;lt; .001), indicating that group 1 had more significant improvement in morphea skin damage but not disease activity compared with group 2. Histologic analysis showed improved skin regeneration and reduced skin sclerosis in group 1, whereas skin biopsy specimens of group 2 patients did not show significant change. Transcriptome analysis of skin biopsy specimens from group 1 patients suggested that tumor necrosis factor α signaling via NFκB might contribute to the immunosuppressive and antifibrotic effect of sequential fat grafting. A total of 15 hub genes were captured, among which many associated with morphea pathogenesis were downregulated and validated by immunohistochemistry, such as EDN1 , PAI-1 , and CTGF . Conclusions and Relevance The results of this nonrandomized trial suggest that sequential fat grafting with fresh fat and cryopreserved SVF gel was safe and its therapeutic effect was superior to that of single autologous fat grafting with improved mLoSSI and LoSDI scores. Histological and transcriptomic changes further support the effectiveness after treatment. Trial Registration Chinese Clinical Trial Registry identifier: ChiCTR2200058003
Health Insurance Status and Unplanned Surgery for Access-Sensitive Surgical Conditions
Authors: Shukri H. A. Dualeh, Sara L. Schaefer, Nicholas Kunnath, Andrew M. Ibrahim, John W. Scott
Journal: JAMA Surgery (2024)

Access-sensitive surgical conditions, such as abdominal aortic aneurysm, ventral hernia, and colon cancer, are ideally treated with elective surgery, but when left untreated have a natural history requiring an unplanned operation. Patients' health insurance status may be a barrier to receiving timely elective care, which may be associated with higher rates of unplanned surgery and worse outcomes.
Home Insulin Pump Use in Hospitalized Children With Type 1 Diabetes
Authors: Jodi Owens, Joshua Courter, Christine L. Schuler, Michelle Lawrence, Lindsey Hornung, Sarah Lawson
Journal: JAMA Network Open (2024)

Pediatric data on inpatient home insulin pumps are absent in the literature. Understanding safety of home insulin pumps, managed by patients or caregivers, during times of illness will help diabetes technology securely move into pediatric hospitals.
Including Cystatin C Levels May Be Better for Diagnosing CKD
Authors: Emily Harris
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sex-Specific Pathways From Prenatal Maternal Inflammation to Adolescent Depressive Symptoms
Authors: Emily Lipner, Naoise Mac Giollabhui, Elizabeth C. Breen, Barbara A. Cohn, Nickilou Y. Krigbaum, Piera M. Cirillo, Thomas M. Olino, Lauren B. Alloy, Lauren M. Ellman
Journal: JAMA Psychiatry (2024)

Importance Prenatal maternal inflammation has been associated with major depressive disorder in offspring in adulthood as well as with internalizing and externalizing symptoms in childhood; however, the association between prenatal inflammation and offspring depression in adolescence has yet to be examined. Objective To determine whether maternal levels of inflammatory biomarkers during pregnancy are associated with depressive symptomatology in adolescent-aged offspring and to examine how gestational timing, offspring sex, and childhood psychiatric symptoms impact these associations. Design, Setting, and Participants This was an observational study of a population-based birth cohort from the Child Health and Development Studies (CHDS), which recruited almost all mothers receiving obstetric care from the Kaiser Foundation Health Plan (KFHP) in Alameda County, California, between June 1959 and September 1966. Pregnancy data and blood sera were collected from mothers, and offspring psychiatric symptom data were collected in childhood (ages 9-11 years) and adolescence (ages 15-17 years). Mother-offspring dyads with available maternal prenatal inflammatory biomarkers during first and/or second trimesters and offspring depressive symptom data at adolescent follow-up were included. Data analyses took place between March 2020 and June 2023. Exposures Levels of inflammatory biomarkers (interleukin 6 [IL-6], IL-8, IL-1 receptor antagonist [IL-1RA], and soluble tumor necrosis factor receptor-II) assayed from maternal sera in the first and second trimesters of pregnancy. Main Outcomes and Measures Self-reported depressive symptoms at adolescent follow-up. Results A total of 674 mothers (mean [SD] age, 28.1 [5.9] years) and their offspring (350 male and 325 female) were included in this study. Higher second trimester IL-6 was significantly associated with greater depressive symptoms in offspring during adolescence ( b , 0.57; SE, 0.26); P = .03). Moderated mediation analyses showed that childhood externalizing symptoms significantly mediated the association between first trimester IL-6 and adolescent depressive symptoms in male offspring ( b , 0.18; 95% CI, 0.02-0.47), while childhood internalizing symptoms mediated the association between second trimester IL-1RA and adolescent depressive symptoms in female offspring ( b , 0.80; 95% CI, 0.19-1.75). Conclusions and Relevance In this study, prenatal maternal inflammation was associated with depressive symptoms in adolescent-aged offspring. The findings of the study suggest that pathways to adolescent depressive symptomatology from prenatal risk factors may differ based on both the timing of exposure to prenatal inflammation and offspring sex.
Respiratory System Compliance Accurately Assesses the “Baby Lung” in Pediatric Acute Respiratory Distress Syndrome
Authors: Pablo Cruces, Sonia Reveco, Paola Caviedes, Franco Díaz
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

"Respiratory System Compliance Accurately Assesses the “Baby Lung” in Pediatric Acute Respiratory Distress Syndrome." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Cell-based Therapies for Acute Respiratory Distress Syndrome: Where Are We Now?
Authors: Gerard F. Curley, Cecilia M. O’Kane, Daniel F. McAuley, Michael A. Matthay, John G. Laffey
Journal: American Journal of Respiratory and Critical Care Medicine (2024)

Section:ChooseTop of pageAbstract <<Insights from ARDS Clinic...Insights from COVID-19 Cl...Insights from GvHDKey Insights and Knowledg...Future Directions: Develo...ConclusionsReferences
Africa’s First Routine Malaria Vaccination Campaign Begins
Authors: Emily Harris
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatric Inpatient Insulin Pump Use and Glycemic Control
Authors: Sarah Rosenheck, Charlotte Chen, Molly O. Regelmann
Journal: JAMA Network Open (2024)

Jodi Owens, MSN, RN; Joshua Courter, PharmD; Christine L. Schuler, MD, MPH; Michelle Lawrence, MSN, RN, NPD-BC, CPN; Lindsey Hornung, MS; Sarah Lawson, MD
The Reliability of Traumatic and Adverse Experiences—Reply
Authors: Andrea Danese, Cathy Spatz Widom
Journal: JAMA Psychiatry (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Health Insurance for Care—Access-Sensitive Surgical Conditions
Authors: Casey M. Silver, Anne M. Stey
Journal: JAMA Surgery (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Hospitals Receiving Drug Discounts Make Large Profits From Markups
Authors: Emily Harris
Journal: JAMA (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for Prostate Cancer With Modern Diagnostics—Another Piece of the Puzzle
Authors: Ola Bratt
Journal: JAMA Network Open (2024)

Tobias Nordström, MD, PhD; Magnus Annerstedt, MD; Axel Glaessgen, MD, PhD; Stefan Carlsson, MD, PhD; Mark Clements, PhD; Ahmad Abbadi, MD; Henrik Grönberg, MD, PhD; Fredrik Jäderling, MD, PhD; Martin Eklund, PhD; Andrea Discacciati, PhD
Contribution of Infant Rhinovirus Bronchiolitis to Hospital Bed and Ventilation Use
Authors: Côme Horvat, Jean-Sebastien Casalegno, Elsa Masson, Clémence Benveniste, Julie Haesebaert, John Paget, Dominique Ploin
Journal: JAMA Network Open (2024)

This cohort study compares the use of hospital resources related to human rhinovirus and respiratory syncytial virus infections among infants during 3 consecutive seasons before nirsevimab implementation.
The Promise and Drawbacks of Federated Learning for Dermatology AI
Authors: Kivanc Kose, Veronica Rotemberg
Journal: JAMA Dermatology (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Incorrect Study Dates and Author Affiliation
Journal: JAMA (2024)

Ravi Prakash Upadhyay, MD; Sunita Taneja, PhD; Ranadip Chowdhury, PhD; Neeta Dhabhai, MD; Savita Sapra, PhD; Sarmila Mazumder, PhD; Sitanshi Sharma, MD; Mark Tomlinson, PhD; Tarun Dua, PhD; Harish Chellani, MD; Rupali Dewan, MD; Pratima Mittal, MD; M. K. Bhan, MD; Nita Bhandari, PhD; Women and Infants Integrated Interventions for Growth Study (WINGS) Group; Ratan Shekhawat; Sabreen Siraj; Sugandhi Nagpal; Farah Abbasi; Heena Chaudhary; Karishma Sharma ; Farhana Rafiqui; Kiran Bhatia; Jasmine Kaur; Medha Shekhar; Anita Kate; Gunjan Aggarwal; Runa Ghosh; Kunal Kishore; Navneet Mehra; Nikita Arya; Ritu Chaudhary; Anuradha Tamaria; Tivendra Kumar; Sowmya Karantha C; Purnima Modi; Neelam Kaur; Neha Tyagi; Geeta Mehto; Afifa Khatun; Sayeed Ahmed; Aparna Singh; Gulafshan Ansari; Ramanjeet Kaur; Manisha Gupta; Girish Chand Pant; Ankita Dutta; Deepak More; Mukesh Kumar; Sonia Kuruvilla ; Anjali Chandra; Pradeep Debata; Anita Yadav; Abhinav Jain; Rahul Sachdev; Omprakash Bansal; Raghav Agarwal
Presentation Acuity and Surgical Outcomes for Patients With Health Insurance Living in Highly Deprived Neighborhoods
Authors: Susanne Schmidt, Michael A. Jacobs, Jeongsoo Kim, Daniel E. Hall, Karyn B. Stitzenberg, Lillian S. Kao, Bradley B. Brimhall, Chen-Pin Wang, Laura S. Manuel, Hoah-Der Su, Jonathan C. Silverstein, Paula K. Shireman
Journal: JAMA Surgery (2024)

Insurance coverage expansion has been proposed as a solution to improving health disparities, but insurance expansion alone may be insufficient to alleviate care access barriers.
Antibiotic Use in Gangrenous, Suppurative, or Exudative Appendicitis
Authors: Fari Fall, Loren Berman
Journal: JAMA Surgery (2024)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses
Authors: Jinye Dai, Jason Aoto, Thomas C. Südhof
Journal: Neuron (2024)

(Neuron 102, 993–1008.e1–e5; June 5, 2019) The source data Excel file and graphs of this paper contained the following errors for which we sincerely apologize. None of the corrections affects the conclusions of experiments. We would like to correct these errors as follows:1.In the source data for the AMPA/NMDA ratios of Figure 2D, we accidentally copy-pasted the dividing formula into the Excel sheet for the “Nrxn1SS4−” condition instead of the actual AMPA/NMDA ratio values. As a result, the data shown were the ratios of the two previous columns (the WT and Nrxn1SS4+ conditions) instead of the AMPA/NMDA ratios of the Nrxn1SS4− condition. The correct values have now been entered into the source data Excel file. The figure is unchanged since it was drafted from the right values of the AMPA/NMDA ratios from the original Excel data file.2.In Figure 4A, the x axis labels of Nrxn1SS4+ and Nrxn1SS4− were switched. 3.In Figure 5E, the data for cell 12 were accidentally pasted twice in the condition “Nrxn2SS4+.” 4In Figure 6A, the data of cell 5 were inadvertently pasted twice instead of the correct data points in the “Nrxn3SS4+” condition. In Figure 6B, cell 12 was accidentally pasted twice from the “Nrxn1SS4+” condition. In addition, the y axes for Figures 6B and 6C were mislabeled; the correct labels are “NMDA total charge” and “GABA total charge,” respectively. 5.In Figure S4, the data in cell 4 and cell 1 of the “Nrxn2SS4+” condition in panels (A) and (B), respectively, as well as cell 5 and cells 5–7 of the “Nrxn2SS4−” condition, were inadvertently pasted from other cells. Download .xlsx (.27 MB) Help with xlsx files Table S1. Data for All Figures, Related to Figures 1, 2, 3, 4, 5, 6, 7, 8, and S1–S8 Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor ResponsesDai et al.NeuronApril 17, 2019In BriefAlternative splicing of presynaptic neurexin-1 and -3 at splice site 4 is shown to regulate the receptor composition of excitatory synapses. Neurexin-1-SS4+ increases NMDA receptor responses, whereas neurexin-3-SS4+ suppresses AMPA receptor responses. Thus, presynaptic neurexin alternative splicing shapes the postsynaptic glutamate receptor composition. Full-Text PDF Open Archive
Preclinical characterization and phase 1 results of ADG106 in patients with advanced solid tumors and non-Hodgkin’s lymphoma
Authors: Yuxiang Ma, Fan Luo, Yang Zhang, Qianwen Liu, Jinhui Xue, Yan Huang, Yuanyuan Zhao, Yunpeng Yang, Wenfeng Fang, Ting Zhou, Gang Chen, Jiaxin Cao, Qun Chen, Xiaohong She, Peter Luo, Guizhong Liu, Li Zhang, Hongyun Zhao
Journal: Cell Reports Medicine (2024)

ADG106, a ligand-blocking agonistic antibody targeting CD137 (4-1BB), exhibits promising results in preclinical studies, demonstrating tumor suppression in various animal models and showing a balanced profile between safety and efficacy. This phase 1 study enrolls 62 patients with advanced malignancies, revealing favorable tolerability up to the 5.0 mg/kg dose level. Dose-limiting toxicity occurs in only one patient (6.3%) at 10.0 mg/kg, resulting in grade 4 neutropenia. The most frequent treatment-related adverse events include leukopenia (22.6%), neutropenia (22.6%), elevated alanine aminotransferase (22.6%), rash (21.0%), itching (17.7%), and elevated aspartate aminotransferase (17.7%). The overall disease control rates are 47.1% for advanced solid tumors and 54.5% for non-Hodgkin's lymphoma. Circulating biomarkers suggest target engagement by ADG106 and immune modulation of circulating T, B, and natural killer cells and cytokines interferon γ and interleukin-6, which may affect the probability of clinical efficacy. ADG106 has a manageable safety profile and preliminary anti-tumor efficacy in patients with advanced cancers (this study was registered at ClinicalTrials.gov: NCT03802955).