tbuckley/cabot-search huggingface dataset:
ENABLING DISABLED PEOPLE TO DRIVE: INFORMATION AND INSTRUCTION SHOULD BE EASIER TO COME BY
Authors: C F Murray-Leslie
Journal: BMJ (1991)

This brief article suggests that disabled drivers may have problems in finding out whom to go to to obtain tuition and advice and attempts to rectify the situation. The obstacles that need to be overcome include finding whether a disabled person is capable of driving a car, getting advice on a suitable vehicle and driving aids, and finding a suitable instructor. Many regions in Britain are now served by assessment centres, nearly all of them equipped to provide test drives in adapted vehicles, and an address is provided for the Forum of Driving Assessment Centres. A peripatetic driving advisor is also available at the Mobility Advice and Vehicle Information Service (MAVIS) based at the Transport Research Laboratory. Some insurance brokers specialise in insuring disabled drivers, and the Disabled Drivers Association should have information on such brokers. Sound advice on driving aids and on the most suitable vehicle remains a problem, as does the ability to find a local driving instructor who is experienced in teaching disabled drivers and has an adapted car. The Banstead Mobility Centre, which runs courses for instructors on teaching disabled drivers is setting up a national disability tuition register. The Association of Driver Education for People with Disabilities also has such a register. Membership includes assessors, motor manufacturers and conversion specialists, as well as doctors and psychologists.
Abstract 18393: Plakophilin-2, Ankyrin-G and Connexin43 Mutually Interact to Regulate Intercellular Coupling and Sodium Channel Function. Implications to Arrhythmogenic Cardiomyopathies?
Authors: Priscila Sato, Xianming Lin, Hassan Musa, Wanda Coombs, Steven Taffet, Lori Isom, Mario Delmar
Journal: Circulation (2010)

Plakophilin-2 (PKP2) is a protein associated with the cardiac desmosome. Mutations in PKP2 have been linked to up to 70% of cases of familial Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) ...
Current developments in pharmacological therapeutics for chronic constipation
Authors: Chunhuan Jiang, Qinglong Xu, Xiaoan Wen, Hongbin Sun
Journal: Acta Pharmaceutica Sinica B (2015)

Chronic constipation is a common gastrointestinal disease severely affecting the patient׳s quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-HT4 receptor modulators velusetrag and naronapride, the guanylate cyclase C agonist plecanatide and the ileal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field.
Pharmaceutical and Medical Chemistry.
Authors: Samuel P. Sadtler, Virgil Coblentz, Jeannot Hostmann, Freeman P. Stroup
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cloud of Consonants and a Vowel
Authors: Carol Snyder Halberstadt
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessing the Reliability of 5S rRNA Sequence Data for Phylogenetic Analysis in Green Plants
Authors: Kelly P. Steele, Kent E. Holsinger, Robert K. Jansen, David W. Taylor
Journal: Molecular Biology and Evolution (1991)

Elimination of compensating substitutions in portions of 5S rRNA sequences that exhibit secondary structure and scoring of common gaps as homologous characters affects both the topology of phylogenetic estimates within green plants and measures of their reliability. Allowing for a transition / transversion bias, on the other hand, has little affect. Detailed analysis of these data results in phylogenetic estimates largely congruent with widely accepted hypotheses of relationships among green plants, but bootstrapping provides little statistical support for most of these groupings. The lack of statistical support is a direct result of both the small number of phylogenetically informative sites in the SS rRNA molecule and the high rate of change at those positions that are free to vary. When considered in conjunction with earlier distance-based analyses of phylogeny that use 5s rRNA, these results demonstrate that phylogenetic estimates based only on analyses of 5S rRNA sequences must be viewed with considerable caution.
Optimal coronary balloon angioplasty with provisional stenting versus primary stent (OCBAS)
Authors: Alfredo Rodríguez, Francisco Ayala, Victor Bernardi, Omar Santaera, Eugenio Marchand, Cesar Pardiñas, Carlos Mauvecin, Daniel Vogel, Lari C Harrell, Igor F Palacios
Journal: Journal of the American College of Cardiology (1998)
Abstract 199: Miniaturized Chest Compressor Improves Neurological Recovery in a Porcine Cardiac Arrest Model
Authors: Wei Chen, Yinlun Weng, Sen Ye, Xiaobo Wu, Shijie Sun, Max H Weil, Wanchun Tang
Journal: Circulation (2011)

During cardiopulmonary resuscitation (CPR), blood flow generated by chest compression is the most important factor for successful resuscitation. In the present study, we investigated the effects of a newly developed miniaturized chest compressor (MCC) on carotid blood flow (CBF) and neurological alertness score (NAS) in a porcine model of cardiac arrest. We hypothesized that MCC would yield equal or better CBF and post resuscitation neurological function when compared to a conventional mechanical device (Thumper). Ventricular fibrillation (VF) was induced in domestic pigs weighing between 35 and 36 kg. CPR was initiated after 7 minutes of untreated VF. Animals were randomized to receive mechanical chest compression with either the MCC or Thumper. Both devices provided the same compression rate of 100/min. The initial compression depth was adjusted to achieve a coronary perfusion pressure (CPP) above 12 mm Hg. After 5 minutes of CPR, a single 150J defibrillation (DF) was delivered. If resuscitation was not successful, CPR was continued for 2 minutes before the next DF. The protocol was continued until successful resuscitation or for a total of 15 minutes. After resuscitation, the NAS was measured daily. All animals were resuscitated except 1 from the Thumper group. The CBF during CPR was significantly greater in the MCC group when compared to the Thumper group (Table). A significantly better NAS was observed after resuscitation in the MCC group (Table). MCC significantly increased CBF during CPR which was associated with a significantly improved postresuscitation neurological function.
Studies on Tsutsugamushi Disease (Japanese Flood Fever).
Authors: 麟也 川村
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histological hepatic changes in patients undergoing liver resection for colorectal metastasis: A retrospective cohort study
Authors: S. M. Allegro, C. Rowsell, C. Law, Y. Ko
Journal: Journal of Clinical Oncology (2009)

e15034 Background: Patients with colorectal cancer (CRC) with liver metastases (LM) have a poor prognosis and the only potential cure is surgical resection. Neoadjuvant chemotherapy (NC) in this setting can increase the success of resection and can potentially improve survival. However, chemotherapy can be associated with hepatic toxicity which may influence postoperative morbidity. Methods: Consecutive patients who underwent hepatectomy for CRC with LM from 1999–2005 at a single institution (OCC) were retrospectively reviewed. Data on baseline characteristics, chemotherapy regimens, operative outcomes and pathology were collected. Results: 107 patients underwent hepatectomy for CRC LM. Median age was 62 years (range 24–84). 53 (53%) patients had positive lymph nodes (primary tumor) and 51 (48%) had with synchronous LM. 46 (43%) patients had a solitary LM and 90 (84%) underwent major resection (&gt;4 segments). 63 (59%) patients received NC. 96% received a 5FU-based regimen. The majority of patients (55%) received 6–12 cycles of NC. The median time between NC and surgery was 6.5 weeks. Patients receiving NC before surgery were younger (mean 59.5 versus 65.5 years, p=0.0056). NC was more often administered in patients with positive primary lymph node status (72%,versus 40%, p=0.0014) and with multiple (versus solitary) LM (75% versus 37%, p=0.0001). Patients more often received NC with synchronous (versus metachronous) LM (90% versus 30%, p&lt;0.0001). Operative and postoperative courses were not significantly different in patients with NC, including hemodynamic instability, postoperative complications, transfusion requirements (red blood cell and platelets) and mortality. Pathological analysis of the resected liver segments reviewed mild (&lt;30%) steatosis in 58% of patients. Most specimens did not reveal lobular inflammation (56%) or ballooning (87%). Sinusoidal injury was most often graded as 1 (33%). There were no significant increased rates of liver toxicity in patients with NC. Conclusions: This study demonstrates that neoadjuvant chemotherapy, although associated with increased steatosis is not associated with increased perioperative morbidity and mortality with liver resection. No significant financial relationships to disclose.
Preliminary Clinical Experience on the Efficacy and Feasibility of a New Combination Regimen Consisting of Pixantrone, Etoposide, and Bendamustine with or without the Addition of Rituximab in Patients with Relapsed/Refractory Aggressive Non-Hodgkin Lymphomas
Authors: Francesco d'Amore, Judit Joergensen, Ida Blok Sillesen, Erik Segel, Hans Bentzen, Michael Thorsgaard, Elisa Jacobsen Pulczynski, Bjarne Bach Pedersen, Dorte Gillström, Michael Clausen, Peter Kamper, Trine Silkjaer, Lars C. Gormsen, Sirpa Leppä, Helle Toldbod
Journal: Blood (2014)
INFECTIVITY OF RIBONUCLEIC ACID FROM POLIOVIRUS IN HUMAN CELL MONOLAYERS
Authors: Hattie E. Alexander, Gebhard Koch, Isabel Morgan Mountain, Olga Van Damme
Journal: The Journal of Experimental Medicine (1958)

Ribonucleic acid prepared by the method of Gierer and Schramm from concentrated and partially purified types I and II polioviruses has been demonstrated to be infectious for HeLa and human amnion cells in monolayers. In areas of cytopathogenic action resulting from invasion of cells by RNA, intact poliovirus, of the type from which the RNA had been prepared, is present. The infectivity of the RNA was completely inactivated by a 2 minute exposure to purified ribonuclease or to whole normal monkey serum shown to contain measurable concentrations of this enzyme. Whole virus infectivity was not influenced by RNAase or whole normal monkey serum. Normal and polio-immune globulin, desoxyribonuclease, lysozyme, proteolytic enzymes, and bovine albumin failed to inactivate the infectivity of RNA. The degree of infectivity of isolated RNA from poliovirus for cells in monolayer was greatly influenced by the ionic strength of the environment. The experimental evidence suggests that isolated poliovirus RNA is the carrier of the biological activity responsible for infection of cells and for transmission of genetic information which controls type specificity.
Abstract 14988: Low Beta-Carotene Levels are Associated with Elevated Insulin and Insulin Resistance in Healthy African American Men and Women
Authors: Edward C Suarez
Journal: Circulation (2012)

Introduction: Lower levels of beta-carotene are associated with increased risk of Type 2 diabetes, glucose intolerance and insulin resistance. Given the higher prevalence of Type 2 diabetes and poor conversion of beta-carotene to retinol in African Americans (AA), it was hypothesized that, relative to Caucasians, AA would exhibit lower beta-carotene levels and lower beta-carotene levels would be associated with insulin resistance in AA. .

Methods: Data were collected on 177 non-smoking, healthy adult men and women (18-65 yrs, 48% women, 33% African American). Fasting blood samples were collected for assessment of beta-carotene, insulin and glucose. Blood samples for premenopausal women were collected during the follicular phase. The Homeostatic model assessment (HOMA) was used to calculate insulin resistance (IR). Multivariate models with age, body mass index, vitamin supplement use, exercise, alcohol intake, education, and total cholesterol as covariates were used to test the interaction between log-transformed beta-carotene and ethnicity. Outcome variables included fasting insulin and glucose and log-transformed HOMA.

Results: Average level of beta-carotene was 21.5 mg/dl. Consistent with previous studies, significantly higher beta-carotene levels were observed in women (p = .008), Caucasians (p = .02) and vitamin supplement users (p < .001). Use of vitamin supplements did not differ by race or gender. Results of multivariate analysis revealed a significant Ethnicity by beta-carotene interaction for HOMA-IR (p = .037) and fasting insulin (p < .001) but not glucose. Among Caucasians, beta-carotene was not associated with HOMA-IR and fasting insulin. In contrast, for African Americans, lower beta-carotene levels were associated with greater HOMA-IR (beta = -0.91, p < .001) and higher fasting insulin (beta = -5.14, p < .001).

Discussion: Independent of potential confounding factors, African Americans exhibited lower beta-carotene levels that were associated with insulin resistance and higher fasting insulin levels, factors associated with increased risk of Type 2 diabetes. These observations may reflect ethnic differences in dietary intake and genetic influences on beta-carotene conversion to retinol in AA.
Medical Genetics Casebook: A Clinical Introduction to Medical Ethics Systems Theory.
Authors: Colleen D. Clements
Journal: Annals of Internal Medicine (1983)

1 (Cases 1-7) Introduction to the Problem:Is an Amniocentesis Program Good Medicine or Social Engineering?.- Curative and Preventive Labels in Medicine.- The Unfragmented Patient.- Cost/Benefit Uses and Abuses.- We Can Never Do Only One Thing: The Ecological Model.- Attitudes Toward Pain and Suffering.- 2 (Cases 8-23) Working with Information.- Lack of Documentation, Verified Diagnosis, or Autopsy.- One Syndrome or Separate Problems.- Catch-All Explanations.- New Syndromes.- 3 (Cases 24-51) Denial and Reality Testing.- How Much Patient Denial Can Be Accepted?.- Anxiety Induction and Lowering.- Perceptions of Risk.- Overmedicalization or Good Medical Practice?.- 4 (Cases 52-74) Self-Image.- The Worth of the Individual.- Carrier Status.- Affected Parents.- Affected Offspring.- Parents' Sense of Responsibility for the Defect.- 5 (Cases 75-92) Experimental Research and Procedures.- Thalassemia Research.- Other Applications of Fetoscopy.- HLA Linkage, Secretor Linkage Research.- Blood Sampling Studies, Amniotic Fluid Sampling Studies, and Psychological Studies.- Future Effects of Environmental Contaminants.- 6 (Cases 93-118) Selective Abortion:Range of Choices and Time Frames.- Counseling Decision After Physician Referral.- Prenatal Testing Decisions.- Abortion Decided Affirmatively or Negatively Before Testing.- Abortion Decided Affirmatively or Negatively with Test Results.- Followup Support for Abortion Decisions.- 7 (Cases 119-130) Social and Individual Interest Conflicts.- Sex Determination and Selection.- Excuse for Aborting Unwanted Pregnancies.- Referral and Feedback.- The Physician in the Dual Role of Filling Social Interests and Individual Interests.- 8 Pragmatics as an Ethical System.- Adaptation and the Pragmatic Criterion.- The Traditional Trio in Medical Ethics.- Pragmatics.- Value of a Systems Model.- The Nature and Justification of Intervention.- The Forgotten Human Condition.- The Worth of Human Beings.- Future Issues in Medical Ethics.- Medicine as Mythology.- Index of Case Studies.
Subcutaneous omacetaxine mepesuccinate in imatinib-resistant chronic myeloid leukemia (CML) patients (Pts) with the T315I mutation: Data from an ongoing phase II/III trial
Authors: J. E. Cortes, H. J. Khoury, S. Corm, F. Nicolini, T. Schenk, D. Jones, A. Hochhaus, A. R. Craig, E. Humphriss, H. Kantarjian
Journal: Journal of Clinical Oncology (2009)

7008 Background: Omacetaxine (OM), a first-in-class cetaxine shows clinical activity against Ph+ CML with a mechanism independent of tyrosine kinase inhibition. Currently available tyrosine kinase inhibitors (TKIs) have no activity against T315I. Methods: Adult Pts with T315I+ CML following TKI failure received OM induction at 1.25 mg/m 2 subcutaneous (SC) twice daily (BID) for 14 days every 28 days followed by maintenance at 1.25 mg/m 2 SC BID for 7 days every 28 days (maintenance after at least one induction cycle and achievement of hematologic response). Results: 66 pts (39 chronic [CP], 16 accelerated [AP] and 11 blast phase [BP]) have been enrolled. All had failed prior imatinib and 80% failed ≥2 prior TKIs. Median age is 58 yrs. Median disease duration is 58 mos. OM is well tolerated with transient myelosuppression as the primary toxicity. Grade 3/4 non-hematologic events are diarrhea (2%) and fatigue (4%). Efficacy data are available for 44 Pts. In CP Pts, the median number of cycles is 4 (1–22) with 39% having received ≥ 6 cycles of therapy; 64% of Pts have had the T315I clone reduced to below detection limits; the 2-year progression free survival is 70%. Conclusions: Omacetaxine in T315I+ CML Pts results in de-selection of the T315I clone and induces hematologic and cytogenetic responses. [Table: see text] [Table: see text]
Nierenphysiologie und funktionelle Nierendiagnostik im Dienste der Nierenchirurgie und der internen Klinik.
Authors: Victor Blum
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12275: Competing Cardiovascular Outcomes Associated with Electrocardiographic Left Ventricular Hypertrophy: The Atherosclerosis Risk in Communities Study
Authors: Chintan S Desai, Hongyan Ning, Donald M Lloyd-Jones
Journal: Circulation (2011)

Background: Individuals with electrocardiographically-determined left ventricular hypertrophy (ECG LVH) are at risk for multiple cardiovascular disease (CVD) outcomes simultaneously. We sought to d...
Abstract 16653: Bioequivalence of Chemoenzymatically Synthesized Bioengineered Heparin versus Porcine USP Heparins
Authors: Shaker A Mousa, Majde Takieddin, Nicole Vartigian, Jonathan S Dordick, Jian Liu, Robert J Linhardt
Journal: Circulation (2013)

Although most pharmaceutical heparin used today is obtained from porcine intestine, heparin has historically been prepared from bovine lung and ovine intestine. There is some regulatory concern abo...