Safety and efficacy of low-intensity versus standard monitoring following intravenous thrombolytic treatment in patients with acute ischaemic stroke (OPTIMISTmain): an international, pragmatic, stepped-wedge, cluster-randomised, controlled non-inferiority trial
Authors: Craig S Anderson, Debbie Summers, Menglu Ouyang, Yi Sui, Brenda Johnson, Laurent Billot, Alejandra Malavera, Roland Faigle, Paula Muñoz-Venturelli, Diana Day, Xiaoqiu Liu, Qiang Li, Lili Song, Thompson G Robinson, Francisca González, Francisca Urrutia-Goldsack, Michael Iacobelli, Michelle Montalbano, April Pruski, Candice Delcourt, Alice C Durham, Ahtasam Ebraimo, Ha Hong Van Ta, Pratiti Ghosh, Ann Leonhardt-Caprio, Huy Thang Nguyen, Mai Duy Ton, Stephen Jan, Hueiming Liu, Richard I Lindley, Antonio Arauz, Andrés Mercado, Wan Asyraf Wan Zaidi, Pooja Khatri, Xia Wang, Victor C Urrutia, Sheila Jala, Susan Day, Ying Hu, Aneeta Lal, Elizabeth O'Brien, Michael Devlin, Carol Bendall, Christianna Nebauer, Duncan Maddox, Melissa Brooks, Timothy Kleinig, Jennifer Cranefield, Samantha McMahon, Roy Drew, Patrick McMullan, Joschka Straha, Donna Rowley, Helen Rodgers, Jessica Pyman, Rohan Grimley, Kylie Tastula, Xiaowen (Erin) Li, Stephen Walker, Alanah Bailey, Julia R Hennessey, Ken S Butcher, Darshan Ghia, Gillian Edmonds, Erin Casey, Lydia Ting, Jane Prosser, Krystle Franklin, Henry Ma, Thanh Phan, Jason Vuong, Berzenn Urbi, Rebecca Phair, Nino Jose, Andrew Shine, Susan Lane, Juliette Mai, F O'Rourke, Christine Fuller, Ravindra Urkude, Nerida Myers, Nicole Bradford, Yi Sui, Wei Bian, Xinze Guo, Yang Zhao, Yang Zhang, Xuchen Qi, Yanxing Zhang, Huan Tang, Xuan Fang, Min Zheng, Mingzong Yan, Yanyan Yin, Penglai Shi, Junmei Li, Junming Luo, Fuqiang Fan, Xueting Guo, Huaxiang Zhou, Xueqing Ba, Yongxia Nie, Chenguang Song, Hong'an Gao, Lili Sun, Chunnan Jia, Mingyue Wang, Lihong Zhang, Jing Yang, Aijie Song, Yanli Zhang, Shuang Yu, Ying Guan, Ruyu Bai, Changqing Li, Tong Bai, Xin Li, Dongyu Wang, Haiyan Yu, Wei Zhao, Nan Li, Hongjun L, Tao Yan, Jinnan Zhang, Shumin Jiang, Yi Shen, Xiaowei Hu, Runhui Li, Li Cui, Yan Kong, Hong Zhang, Shuang Yang, Guiying Guo, Xiaochen Zhao, Haishan Zhao, Fan Zhang, Siheng Li, Yan Yang, Ying Wang, Haiyan Jin, Zijia Liu, Ping Jiang, Hongquan Jiang, Yao Shai, Ying Tang, Jing Xue, Xinyu Dong, Jinchun Wang, Jingyu Guo, Xiuying Wang, Yihe Bao, Hongyan Li, Xiangna Yang, Longna Xie, Shanshan Zhang, Xinxin Yang, Minglei Qu, Dan Deng, Jianghua Liu, Zhonglei Bao, Tieyan Wang, Li Lin, Cheng Bi, Ying Pan, Xinli Chen, Na Gao, Bo Peng, Guozhi Lu, Zidian Jiang, Yongmei Pan, Lianjing Kang, Chunxue Zhu, Lei Zhang, Yan Liang, Huiping Peng, Baiyan Song, Lilan Xiao, Jingyun Kuang, Xuejiao Lu, Xueying Liao, Zefeng Tan, Weiqi Zeng, Wanyi Lin, Enyang Zhou, Jun Wu, Yiqiao Chen, Yajun Liu, Li Meng, Zuo Wang, Yang Liu, Xuefeng Xu, Wei Xu, Yongyi Dai, Yong'e Dong, Yi'nan Zhang, Xiaodi Wang, Ying Hai, Zhi Li, Ying Pei, Guosheng Zheng, Chenyao Li, Zhifei Wang, Yundong Shi, Shanshan Li, Zhichen Liu, Jiaxin Zhang, Liying Cui, Xiaowei Zhao, Yu Qiao, Li Liu, Jingyu Zhang, Changhao Jiang, Cheng Fang, Rui Su, Chenwen Zhang, Yi Ren, Liyang Zhang, Yan Liu, Mingming Dong, Ting Yang, Sirui Gao, Rong Yin, Zhongxia Fu, Yuanming Li, Yaqin Ke, Xiaoxiao Liu, Hongguang Gao, Ying Liu, Chao Wang, Yang Liu, Bo Zhang, Zhenli Guo, Qian Tan, Wanhua Zhong, Ke Ling, Shi'e Ma, Yi Cheng, Ying Bi, Fei Jiang, Yuying Hao, Xiaoxi Yao, Zhiying Wang, Mengju Lei, Liya Lei, Dongyou Yue, Hanyan Xiao, Shuhua Chen, Yiqun Chao, Guangzhao He, Yan Li, Muhui Lin, Jiao Lv, Caixia Liu, Juan Feng, Xuedong Zhao, Xue Yang, Haiyang Yu, Ning Ma, Xuerong Lu, Runzhe Jiang, Xuemei Sun, Na Liu, Yan Zhuang, Andrés Silva-Pozo, Philippe Grandjean Silva, Nataly Cisterna Carrera, Enrico Mazzon, Alejandro Brunser, Pablo Brinck, Andrés Gallardo, Pablo Gonzalez Valdivieso, Juan Almeida, Olivia Sanhueza Neira, Astrid Haleby, Aldo Letelier Durán, Denisse Wenger, Pedro Canales, Keren Zambrano, Camila Rojas, Diego Rocha Jiménez, Mario Rivera, María Jose Orellana, Juan Polanco, Tomás Esparza, Wan Asyraf, Tan Hui Jan Tan, Rabani Remli, Wan Nur Nafisah Wan Yahya, Khoo Ching Soong, Law Zhe Kang, Siti Zaleha Sahibulddin, Dayang Anis Binti Awang Baki, Hamidah Hassan, Nur Liyana Rahmat, Nur Arifah Mohd Khaili, Rathika Rajah, Tan Juen Kiem, Abdul Hanif Khan Yusof Khan, Adnan Lutfi A. Rauf, Shi Hajjar Zakaria, Sanihah Abdul Halim, Jafri Malin Abdullah, Zamzuri Idris, Kamarul Aryffin Bin Baharuddin, Muhammad Ihfaz Ismail, Law Wan Chung, Tay Jiann Shyang, Anderson Steven, Wong Siaw Cheng, Sim Chun Yang, Sheila Ong, Judith James, Irene Looi, Antonio Arauz, Andrés Mercado-Pompa, Vanessa Cano-Nigenda, Ricardo Romero-Vucovich, Pablo Nava-Sánchez, Alejandro López-Pizano, Ranferi E. Herrera-Calderón, Fernando Góngora-Rivera, Adrian Infante-Valenzuela, Ricardo López-Soto, Raymundo Chávez-Gamboa, Luis Daniel Arreola-Sánchez, Gustavo Gonzalez Gonzalez, Sebastián León Vallejo, José Luis Galvez Romero, María Del Rocio Marquez Estudillo, Daniel Reyes Ortega, Amado Jiménez-Ruiz, José Luis Ruiz-Sandoval, Victor Aguilar-Fuentes, Juan Antonio Sotelo-Ramirez, Ricardo Gabriel Ascencio-Tene, Eric De la Cruz Estrada, Victor Mateo Perez, Duy Ton Mai, Viet Phuong Dao, Tien Dung Nguyen, Tuan Anh Le, Quoc Viet Bui, Thi Phuong Nga Nguyen, Thi Thuy Uyen Le, Thi Ngoc Nhung Tran, Thai Hoang Nguyen, Quoc Huy Nguyen, Duc Chien Vo, Trung Thanh Tran, Thai My Phuong Nguyen, Hao Nhien Cao, Linh Tuyen Nguyen, Huy Thang Nguyen, Nguyen Binh Pham, Thanh Thai An Nguyen, Quang Huy Dang, Thi Kim Anh Nguyen, Tri Thanh Vu, Tran Vinh Le, Cong Tri Le, Nguyen Mai Thao Dang, Thi Thu Trang Nguyen, Rachel Teal, Jeethu Joseph, Phil Mathieson, James Kennedy, Tim Comont, Gillian Cumberbatch, Ana Margarida Castanheira, Cai Hua Sim, Rita Ghatala, Kate Kennedy, Beatrix Sari, Jatinder Minhas, Kashif Musarrat, Shagufta Khan, Tracy Harris, Jennifer Mitchell-Douglas, Smriti Agarwal, Arshi Iqbal, Karolina Kowalska, Alex McGovern, Joel Stanton, Marilena Marinescu, Shez Feerick, Sabaa Obarey, Georgia Raingold, Katie Flanagan, Gemenelie Ann Revilla, Roberto Avila, Rose Kennedy, Yee Chin Lee, James Lyon, Alexandra Lewis, Riham El Sayed, None Jannine, Bianca Bandiola, Lance Vincent Sese, Kevin Babia, Zubeda Nungu, Joice Timotec, Stephanie Drysdale, Maria Consuelo Tibasia, Caroline Domingos Belo, Samantha Bayhonan Rubern, Beatrix Sari, Aaizza Naqvi, Emma Richards, Jo Howe, Chris Kamara, Sadaf Younis, Saul Sundayi, Lakshmanan Sekaran, Lisa Reid, Jimy David, Lincy Poolon, Mair A Carpenter, Balasubramanian Venkatesh, Charity W Kimaru, Courtney Greaves, Sarah E Watson, Daniel Ryan, Nichola Kearsley, Natalie Temple, Kirsty Allen, Dan Arcoria, Zoey Horne, Emelda Veraque, Junyao Zhao, Susan Evans, Alix Baird, Tomas Hannam-Penfold, Simon Smith, Camille Hutchinson, Amanda Hedstorm, Lucy Gray, Rachael Jones, Tegan Taylor, Blessing Oduh, Nasar Ahmad, Rachel Evans, Esther Erumere, Brittany Sanders, Edward Kinsella-Perks, Kevin Villa, Samantha Keenan, Sharon Finch, Rebecca Page, Lucy Topliss, Thirukumaran Duraisami, Tamsyn Pattenden, Katie Morgan, Emilie Williams, Nicola Yeo, Sonia Mariampillai, Ruth Penn, Marjorie Castillo, Nicola Cook, Susan Campbell, Shumita Palit, Helen Tench, Ronda Loosley, Tanya Sims, Rebecca Wolf-Roberts, Cerrys Parker, Senthil Kumar Subbarayan, Linda O'Brien, Victoria Riddell, Anna Smith, Cristopher Price, Mark Garside, Nina Jensen, Yaw Duodu, Cheryl Padilla-Harris, Patricia Avila Del Puerto, Bernard Esisi, Emma Clarkson, Mike Murrey, Vivek Rai, Megan Heckathorn, Heather Bartelt, Michelle Hill, Dalida Akhmedova, Brian Silver, Christina Manxhari, Tatiana Thompson, Michelle Manxhari, Ann Leonhardt-Caprio, Emily Prentiss, Curtis Benesch, Paige Hepple, Raymond Reichwein, Cesar Velasco, Andrea Singer, Erin Cekovich, Alicia Richardson, Olivia Christman, Leonard Kishel, Iftekhar Ahmed, Jana Braklow, Richard Smith, Jennifer McMahon, Carly Rossi, Alex Graves, Julie Schafer, Jamie Lynch, Sheryl Giambartolomei, Maria Aguilar, Melissa Ortiona, Elizabeth Dienst, Karin Olds, Debbie Summers, Christine Kennish, Claranne Mathiesen, Erin Conahan, Vivek Rai, Megan Heckathorn, Heather Bartelt, Michelle Hill, Dalida Akhmedova, Pramod Sethi, Sharon Biby, Amber Carter, Jessica Buckner, McNeill Kirkpatrick, Jindong Xu, Tammy Blackburn, Hannah Bell, Karen Newnam, Hannah Mack, Sarah Hocutt, Laith Altaweel, Saqib Chaudhry, Laura Madarász, Karlie Smith, Stefannie Belardo, Tugce Karageyer, Mihaela Alexander, Danielle Hagedorn, Nicole Westensee, Lisa Cohen, Teresa Wiegand, John (Hughes) Barghols, Russell Wheeler, Keri Smith, Kathy Stilwell, Victor Urrutia, Brenda Johnson, Jaime Butler, Roland Faigle, Amer AlShekhlee, Chizoba Ezepue, Bridget Gatscher, Richard King, Mike Ke, Gloria Dow, Michael Seamon, Travis Smith, Burton Tabaac, Kristen Gurnea, Jeffery Webb, Michael Phipps, Chad Schrier, Ann Leonhardt-Caprio, Emily Prentiss, Bruce Silverman, Nicole Green, Jean Kelly, Lynne Froehlich, Craig Anderson, Victor Urrutia, Brenda Johnson, Debbie Summers, Roland Faigle, Diana Day, Thompson Robinson, Paula Muñoz Venturelli, Pooja Khatri, Richard Lindley, Xia Wang, Yi Sui, Lili Song, Wan Asyraf, Huy Thang Nguyen, Robert Herbert, Andrew Barreto, Karen S. Rapp, Laurent Billot, Qiang Li, Xiaoqiu Liu, Yinyan Wang, Qiao Han, Menglu Ouyang, Hueiming Liu, Lizheng Xu, Stephen Jan, Rachel Tang, Michelle Montalbano, April Pruski, Francisca González, Diana Day, Alejandra Del Rio Weldt, Alejandro Jesus López Pizano, Siti Zaleha Sahibulddin, Nur Liyana Rahmat, Nur Afrifah Mohd Khaili, Dayang Anis, Hamidah Hassan, Ahtasam Ebraimo, Ranjit J. Injety, Alejandra Malavera, Ha Hong Van (Melanie) Ta, Pratiti Ghosh, Natalie Espinosa, Lauren Clancy, Aisling Byrne, Luke Hatchwell, Alexandra Hurden, Antonio Michell, Manuela Armenis, Ravikumar Tummapudi, Ullas Arabhavi, Menglu Ouyang, Jipeng Cheng, Zhuo Meng, Alice Durham, Ahtasam Ebraimo, Uyen Hong, Linh Le Thi My, Nguyen Nhat Ha, Thi Thao Van, Thi Kim Nhung, Tuyet Mai, Nhat Phuong Ha, Thi Huong Giang, Nhat Linh, Thi Kim Chi, Thi Nhi, Hai Ngo Thanh, Paula Muñoz Venturelli, Francisca González, Francisca Urrutia Goldsack, Alejandra Del Rio Weldt
Journal: The Lancet (2025)