ASPECTS OF THE ACTION OF INSULIN
Authors: C H BEST
Journal: Annals of Internal Medicine (1953)

Article1 September 1953ASPECTS OF THE ACTION OF INSULINCHARLES H. BEST, C.B.E., M.D., F.R.S.CHARLES H. BEST, C.B.E., M.D., F.R.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-3-433 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe award of the John Phillips Memorial Lectureship and Medal from this College has given me deep pleasure and great encouragement. I knew Dr. Phillips and therefore do not depend entirely on the statements of others in appreciating why you have perpetuated his name with these annual distinctions. John Phillips was a classmate in Medicine in Toronto with teachers, colleagues and close friends of mine—Drs. Edward Gallie, John Oille, George Wilson and the late Gerald FitzGerald.†John Oille won the Gold Medal when they were graduated 50 years ago this spring. John Phillips and George Wilson won Silver Medals. From...Bibliography1. Schoenheimer R: The dynamic state of body constituents, 1942, Harvard University Press, Cambridge. Google Scholar2. BantingBestCollipMacleodNoble FGCHJBJJEC: Preliminary studies on the physiological effects of insulin, Tr. Roy. Soc. Canada (Sect. V, Biol. Sc.) 1922, 1-18. Google Scholar3. StettenBoxer DGE: Studies in carbohydrate metabolism. III. Metabolic defects in alloxan diabetes, J. Biol. Chem. 156: 271-278, 1944. CrossrefGoogle Scholar4. StettenKlein DBV: Studies in carbohydrate metabolism; origin of stable hydrogen in glycogen formed from various precursors, J. Biol. Chem. 165: 157-162, 1946. CrossrefMedlineGoogle Scholar5. BlochKramer KW: The effect of pyruvate and insulin on fatty acid synthesis in vitro, J. Biol. Chem. 173: 811-812, 1948. CrossrefMedlineGoogle Scholar6. GurinCrandall SDI: Lipid metabolism, Ann. Rev. Biochem. 20: 179-208, 1951. CrossrefMedlineGoogle Scholar7. BradyGurin ROS: Biosynthesis of labeled fatty acids and cholesterol in experimental diabetes, J. Biol. Chem. 187: 589-596, 1950. CrossrefMedlineGoogle Scholar8. FeltsChaikoffOsborn JMILMJ: Insulin and the fate of lactate in the diabetic liver, J. Biol. Chem. 191: 683-692, 1951. CrossrefMedlineGoogle Scholar9. ChernickChaikoffMasoroIsaeff SSILEJE: Lipogenesis and glucose oxidation in the liver of the alloxan-diabetic rat, J. Biol. Chem. 186: 527-534, 1950. CrossrefMedlineGoogle Scholar10. BakerChaikoffSchusdek NILA: Effect of fructose on lipogenesis from lactate and acetate in diabetic liver, J. Biol. Chem. 194: 435-443, 1952. CrossrefMedlineGoogle Scholar11. PopjakBeeckmans GML: Extrahepatic lipid synthesis, Biochem. J. 47: 233-238, 1950. CrossrefMedlineGoogle Scholar12. WeinhouseMedesFloyd SGNF: Fatty acid metabolism. The mechanism of ketone body synthesis from fatty acids, with isotopic carbon as tracer, J. Biol. Chem. 155: 143-151, 1944. CrossrefGoogle Scholar13. BradyLukensGurin ROFDS: Hormonal influence upon the in vitro synthesis of radioactive fatty acids, Science 113: 413-415, 1951. CrossrefMedlineGoogle Scholar14. VilleeHastings CAAB: The utilization in vitro of C14-labeled acetate and pyruvate by diaphragm muscle of rat, J. Biol. Chem. 181: 131-139, 1949. CrossrefMedlineGoogle Scholar15. SacksSinex JFM: Effect of insulin on phosphate transport and glucose metabolism, Federation Proc. 11: 135, 1952. Google Scholar16. WickDruryBancroftMacKay ANDRRWEM: Action of insulin on the extrahepatic tissues, J. Biol. Chem. 188: 241-249, 1951. CrossrefMedlineGoogle Scholar17. FellerChaikoffStrisowerSearle DDILEHGL: Glucose utilization in the diabetic dog, studied with C14-glucose, J. Biol. Chem. 188: 865-880, 1951. CrossrefMedlineGoogle Scholar18. BearnBillingSherlock AGBHS: The response of the liver to insulin in normal subjects and in diabetes mellitus: hepatic vein catheterisation studies, Clin. Sc. 11: 151-165, 1952. Google Scholar19. Gemmill CL: The effect of insulin on the glycogen content of isolated muscles, Bull. Johns Hopkins Hospital 66: 232-244, 1940. Google Scholar20. Nelson JF: The anti-insulin action of anterior pituitary extracts, Australian J. Exper. Biol. and M. Sc. 22: 131-133, 1944. CrossrefGoogle Scholar21. Krahl ME: The effect of insulin and pituitary hormones on glucose uptake in muscle, Ann. New York Acad. Sc. 54: 649-670, 1951. CrossrefMedlineGoogle Scholar22. Krahl ME: Hormones and the metabolism of isolated tissues, Diabetes 2: 26-30, 1953. CrossrefMedlineGoogle Scholar23. Gourley DR: Effects of insulin on intact rat leg muscle, Federation Proc. 12: 55, 1953. Google Scholar24. LevineGoldsteinHuddlestunKlein RMSBSP: Action of insulin on the "permeability" of cells to free hexoses, as studied by its effect on the distribution of galactose, Am. J. Physiol. 163: 70-76, 1950. CrossrefMedlineGoogle Scholar25. MirskyHaftPerisutti IADG: Action of insulin on uptake of sugars by isolated rat diaphragm, Federation Proc. 12: 100, 1953. Google Scholar26. BantingBestCollipCampbellFletcher FGCHJBWRAA: Pancreatic extracts in the treatment of diabetes mellitus, Canad. M. A. J. 12: 141-146, 1922. MedlineGoogle Scholar27. BantingCampbellFletcher FGWRAA: Insulin in the treatment of diabetes mellitus, J. Metab. Research 2: 547-604, 1922. Google Scholar28. Allan FN: The glucose equivalent of insulin in depancreated dogs, Am. J. Physiol. 67: 275-290, 1924. CrossrefGoogle Scholar29. JanneyShapiro NWI: Role of insulin in protein metabolism, Arch. Int. Med. 38: 96-108, 1926. CrossrefGoogle Scholar30. Tashiro K: Effect of guanidine and insulin upon blood urea-nitrogen concentration, Tohoku J. Exper. Med. 7: 268-277, 1926. CrossrefGoogle Scholar31. LuckMorrisonWilbur JMGLF: Effect of insulin on the amino acid content of blood, J. Biol. Chem. 77: 151-156, 1928. CrossrefGoogle Scholar32. MirskySwadeshRansohoff IASJ: Influence of insulin on amino acid utilization, Proc. Soc. Exper. Biol. and Med. 37: 223-225, 1937. CrossrefGoogle Scholar33. Mirsky IA: The influence of insulin on the protein metabolism of nephrectomized dogs, Am. J. Physiol. 124: 569-575, 1938. CrossrefGoogle Scholar34. FrameRussell EGJA: The effects of insulin and anterior pituitary extract on the blood amino nitrogen in eviscerated rats, Endocrinology 39: 420-429, 1946. CrossrefMedlineGoogle Scholar35. RussellCappiello JAM: The relationship of temperature and insulin dosage to the rise in plasma amino nitrogen in the eviscerated rat, Endocrinology 44: 127-133, 1949. CrossrefMedlineGoogle Scholar36. InglePrestrudNezamis DJMCJE: Effect of insulin upon level of blood amino acids in eviscerated rat as related to level of blood glucose, Am. J. Physiol. 150: 682-685, 1947. CrossrefMedlineGoogle Scholar37. ChaikoffForker ILLL: The antidiabetic action of insulin on nitrogen metabolism, Endocrinology 46: 319-326, 1950. CrossrefMedlineGoogle Scholar38. Hoberman HD: Endocrine regulation of amino acid and protein metabolism during fasting, Yale J. Biol. and Med. 22: 341-367, 1950. MedlineGoogle Scholar39. ForkerChaikoffEntenmanTarver LLILCH: Formation of muscle protein in diabetic dogs, studied with S35-methionine, J. Biol. Chem. 188: 37-48, 1951. CrossrefMedlineGoogle Scholar40. Lotspeich WD: Relations between insulin and pituitary hormones in amino acid metabolism, J. Biol. Chem. 185: 221-229, 1950. CrossrefMedlineGoogle Scholar41. Luetscher JA: The metabolism of amino acids in diabetes mellitus, J. Clin. Investigation 21: 275-279, 1942. CrossrefMedlineGoogle Scholar42. SinexMacMullenHastings FMJAB: The effect of insulin on the incorporation of C14 into the protein of rat diaphragm, J. Biol. Chem. 198: 615-619, 1952. CrossrefMedlineGoogle Scholar43. Krahl ME: Incorporation of C14-amino acids into glutathione and protein fractions of normal and diabetic rat tissues, J. Biol. Chem. 200: 99-109, 1953. CrossrefMedlineGoogle Scholar44. Young FG: Growth and diabetes in normal animals treated with pituitary (anterior lobe) diabetogenic extract, Biochem. J. 39: 515-536, 1945. CrossrefMedlineGoogle Scholar45. BakerAbramsIngleLi BLGDDJCH: The influence of somatotropin and corticotropin on the islets of Langerhans of the rat, Anat. Rec. 115: 278-279, 1953 (abstract). Google Scholar46. HaistEvansKinashBryansAshworth REMBFEMA: Factors affecting the volume of the islands of Langerhans, Proc. Am. Diabetes A. 9: 51-62, 1949. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Toronto,*Presented as the John Phillips Memorial Lecture at the Thirty-Fourth Annual Session of the American College of Physicians, Atlantic City, New Jersey, April 15, 1953.†Professor W. E. Gallie, head of the Department of Surgery, University of Toronto, for many years; Dr. John Oille, dean of Canadian cardiologists; Dr. George Wilson, head of Surgery, St. Michael's Hospital, Toronto, for many years; Professor J. G. FitzGerald, founder of the Connaught Laboratories and School of Hygiene, University of Toronto. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe mechanism of action of insulinGlycosuriaIntroductionDiabetes mellitus: observations, theoretical and practicalOVEREATING AND VASCULAR DEGENERATION: EXCESSES CAUSING INSUFFICIENCIESThe mechanism of action of insulinPREMATURE VASCULAR DEGENERATION IN DIABETES MELLITUS: PATHOGENESIS, AND RELATION TO AGINGDie Serumlipoide unter besonderer Ber�cksichtigung des PlasmalogensÜber die Beziehungen zwischen Insulin und Zink in den Langerhansschen Inseln des PankreasThe Mechanism of Action of Insulin 1 September 1953Volume 39, Issue 3Page: 433-443KeywordsHygieneInsulinSurgery ePublished: 1 December 2008 Issue Published: 1 September 1953 Copyright & PermissionsCopyright, 1953, by The American College of PhysiciansPDF downloadLoading ...