tbuckley/cabot-search huggingface dataset:
Genetic Association of Juvenile Idiopathic Arthritis With Adult Rheumatic Disease
Authors: Jingxian Fan, Jian Hao, Yuqiao Fu, Xiaoyang Liu, Hui-Qi Qu, Joseph T. Glessner, Dandan Ji, Wei Liu, Gang Zheng, Zhiyong Ding, Shuzhong Cui, Qianghua Xia, Hakon Hakonarson, Wei Wei, Jin Li
Journal: JAMA Network Open (2024)

Importance Patients with juvenile idiopathic arthritis (JIA) may develop adult rheumatic diseases later in life, and prolonged or recurrent disease activity is often associated with substantial disability; therefore, it is important to identify patients with JIA at high risk of developing adult rheumatic diseases and provide specialized attention and preventive care to them. Objective To elucidate the full extent of the genetic association of JIA with adult rheumatic diseases, to improve treatment strategies and patient outcomes for patients at high risk of developing long-term rheumatic diseases. Design, Setting, and Participants In this genetic association study of 4 disease genome-wide association study (GWAS) cohorts from 2013 to 2024 (JIA, rheumatoid arthritis [RA], systemic lupus erythematosus [SLE], and systemic sclerosis [SSc]), patients in the JIA cohort were recruited from the US, Australia, and Norway (with a UK cohort included in the meta-analyzed cohort), while patients in the other 3 cohorts were recruited from US and Western European countries. All analyses were conducted between September 2023 and April 2024. Exposures Genetic associations. Main Outcomes and Measures Genetic correlations and shared genomic loci between JIA and adult rheumatic diseases. Genetic correlation analyses and cross-trait meta-analysis were conducted on the JIA cohort and the summary statistics of the GWASs from adult rheumatic diseases (RA, SLE, and SSc). Mendelian randomization analyses were also conducted. Results This study included 33 207 patients across the 4 cohorts, with 4550 patients in the meta-analyzed JIA cohort (JIA cohort: 1485 patients with arthritis onset before 16 years; 1017 female [68.5%]; 10 352 controls; UK cohort: 3305 patients with JIA; 9196 controls), 143 61 patients in the RA cohort, 5201 patients in the SLE cohort; and 9095 patients in the SSc cohort. After the GWAS result of the JIA cohort was meta-analyzed with the UK JIA cohort, there was a total of 4550 JIA cases and 18 446 controls. The analysis revealed a significant global correlation between JIA and adult rheumatic diseases, with 84 regions harboring signals associated with multiple diseases. Cross-trait analyses uncovered novel disease loci and 20 loci associated with JIA and adult diseases. Mendelian randomization analysis revealed the significant association of 11 proteins with rheumatic disorders. Both shared, organ-specific, and disease-specific critical cell types were highlighted. Conclusions and Relevance In this genetic association study, there was significant genetic overlap between JIA and adult rheumatic diseases. These findings may help to refine JIA classification, risk stratification, and therapeutic strategy of repurposing adult disease drugs for pediatric patients with similar mechanisms.
Household Food Allergen Exclusion Practices and Food Allergy-Related Psychosocial Functioning
Authors: Hana B. Ruran, Gabrielle D’Ambrosi, Roxanne Dupuis, Linda J. Herbert, Scott H. Sicherer, Wanda Phipatanakul, Lisa M. Bartnikas
Journal: JAMA Network Open (2024)

This cross-sectional study examines households that exclude allergens by specific food allergy and the association of food allergy-related psychosocial functioning.
Global Measles Cases Rose 20% in 1 Year as Vaccine Coverage Fell Short
Authors: Samantha Anderer
Journal: JAMA (2024)

Measles cases worldwide rose by 20% in a single year—from about 8.6 million in 2022 to 10.3 million in 2023, which the World Health Organization (WHO) and the US Centers for Disease Control and Prevention (CDC) attributed to insufficient immunization coverage.
Prevalence of Disability Among Older Adults in Prison
Authors: Katherine E. M. Miller, Karen Shen, Yang Yang, Brie A. Williams, Jennifer L. Wolff
Journal: JAMA Network Open (2024)

Importance The number of older adults in long-term correctional facilities (prisons) has increased rapidly in recent years. The cognitive and functional status of this population is not well understood due to limitations in the availability of longitudinal data. Objective To comparatively examine the prevalence and disability status of the population of adults 55 years and older in prisons and adults living in community settings for a 14-year period (2008-2022). Design, Setting, and Participants This repeated cross-sectional study used nationally representative data from the American Community Survey to identify cohorts of community-dwelling adults 55 years or older and adults 55 years or older in prisons. Data were accrued from surveys from 2008 to 2022 and analyzed from August 25, 2023, to October 18, 2024. Exposure Residence in federal or state prison. Main Outcomes and Measures Self-reported cognitive, ambulatory, independent living, or self-care difficulties. Results The population of older adults in prisons increased between 2008 and 2022 from 102 700 to 171 700, but the pace of growth slowed during the COVID-19 pandemic. The analysis included 32 623 adults 55 years or older in prison (mean [SD] age, 62.6 [8.3] years; 28 927 [89.64%] male) and 13 877 665 living in the community (mean [SD] age, 67.4 [9.5] years; 7 497 784 [54.02%] female). Disability prevalences in all categories, including cognitive, ambulatory, independent living, and self-care difficulties, were significantly higher compared with their community-dwelling peers. The difference was particularly stark for cognitive difficulty, which was 15.2% (95% CI, 14.8%-15.7%) for older adults in prisons vs 7.1% (95% CI, 7.1%-7.2%) in the community, after adjusting for demographic characteristics. These prevalences have remained stable over the sample period, including the COVID-19 pandemic. Conclusions and Relevance Results of this cross-sectional study suggest that adults in prison are more likely to report disability than those in community settings, with the largest differences in cognitive difficulties. These differences persisted during the COVID-19 pandemic. The notable increase among older adults in prisons coupled with the high prevalences of disability has important implications for identifying care models and environmental policies to address the chronic and end-of-life care needs of this population, particularly within the context of constrained resources of health care in prisons.
Epidemiology and Outcomes of Alcohol-Associated Hepatitis in Adolescents and Young Adults
Authors: Jennifer A. Flemming, Maya Djerboua, Orli Chapman, Oyedeji Ayonrinde, Norah A. Terrault
Journal: JAMA Network Open (2024)

Importance Alcohol-associated hepatitis (AH) has high mortality, and rates are increasing among adolescents and young adults (AYAs). Objective To define the sex-specific epidemiology of AH in AYAs and the association between female sex and liver-related outcomes after a first presentation of AH. Design, Setting, and Participants A retrospective, population-based cohort study of routinely collected health care data held at ICES from Ontario, Canada, was conducted. Data on AYAs (age, 13-39 years) with first presentation of AH without a history of cirrhosis and/or decompensation from January 1 to December 31, 2022, were included in the analysis. Exposures Study year and female sex. Main Outcome and Measures Overall and sex-specific yearly rates of AH were compared using Poisson regression and rate ratios (RRs). Associations between female sex and incident cirrhosis and/or decompensation were evaluated using competing risks regression, and liver-related mortality by sex was evaluated with cumulative incidence functions. Results A total of 3340 AYAs with AH were identified. Median age was 33 (IQR, 28-36) years, and the population included 1190 (36%) females and 2150 (64%) males. Rates of AH increased by 8% per year (RR, 1.08; 95% CI, 1.07-1.09), with yearly rates increasing faster among females (RR, 1.11; 95% CI, 1.09-1.12) than males (RR, 1.07; 95% CI, 1.06-1.07). A total of 2374 individuals (71%) were alive without cirrhosis 6 months after AH presentation. Of those, 527 (22%) developed incident cirrhosis and/or decompensation after a median follow-up of 4 (IQR, 2-9) years (37% females vs 29% males; P &amp;amp;lt; .001). After adjustment, female sex was associated with a 47% higher subhazard of cirrhosis and/or decompensation compared with male sex (38%) (subhazard, 1.47; 95% CI, 1.23-1.76; P &amp;amp;lt; .001). The cumulative incidence of liver-related mortality at 10 years was higher among females (11.0%; 95% CI, 8.3%-14.2%) than males (6.9%; 95% CI, 5.4%-8.6%) ( P = .01). Conclusions and Relevance Over the past 2 decades, the rates of AH among AYAs increased significantly, with the greatest increase observed among females. The findings of this study suggest sex-specific interventions to prevent the development of AH and the progression to cirrhosis after an episode of AH are needed.
Estimated Vaccine Effectiveness for Pediatric Patients With Severe Influenza, 2015-2020
Authors: Kelsey M. Sumner, Leila C. Sahni, Julie A. Boom, Natasha B. Halasa, Laura S. Stewart, Janet A. Englund, Eileen J. Klein, Mary A. Staat, Elizabeth P. Schlaudecker, Rangaraj Selvarangan, Christopher J. Harrison, Geoffrey A. Weinberg, Peter G. Szilagyi, Monica N. Singer, Parvin H. Azimi, Benjamin R. Clopper, Heidi L. Moline, Emma K. Noble, John V. Williams, Marian G. Michaels, Samantha M. Olson, Jennifer E Schuster
Journal: JAMA Network Open (2024)

Importance Increasing the understanding of vaccine effectiveness (VE) against levels of severe influenza in children could help increase uptake of influenza vaccination and strengthen vaccine policies globally. Objective To investigate VE in children by severity of influenza illness. Design, Setting, and Participants This case-control study with a test-negative design used data from 8 participating medical centers located in geographically different US states in the New Vaccine Surveillance Network from November 6, 2015, through April 8, 2020. Participants included children 6 months through 17 years of age who were hospitalized or presented to an emergency department (ED) with acute respiratory illness. Exposures Receipt of at least 1 dose of the current season’s influenza vaccine. Main Outcomes and Measures Demographic and clinical characteristics of patients presenting to the hospital or ED with or without influenza were recorded and grouped by influenza vaccination status. Estimated VE against severe influenza illness was calculated using multiple measures to capture illness severity. Data were analyzed between June 1, 2022, and September 30, 2023. Results Among 15 728 children presenting for care with acute respiratory illness (8708 [55.4%] male; 13 450 [85.5%] 6 months to 8 years of age and 2278 [14.5%] 9-17 years of age), 2710 (17.2%) had positive influenza tests and 13 018 (82.8%) had negative influenza tests (controls). Of the influenza test–positive cases, 1676 children (61.8%) had an ED visit, 896 children (33.1%) required hospitalization for noncritical influenza, and 138 children (5.1%) required hospitalization for critical influenza. About half (7779 [49.5%]) of the children (both influenza test positive and test negative) were vaccinated. Receiving at least 1 influenza vaccine dose was estimated to have a VE of 55.7% (95% CI, 51.6%-59.6%) for preventing influenza-associated ED visits or hospitalizations among children of all ages. The estimated VE was similar across severity levels: 52.8% (95% CI, 46.6%-58.3%) for ED visits, 52.3% (95% CI, 44.8%-58.8%) for noncritical hospitalization, and 50.4% (95% CI, 29.7%-65.3%) for critical hospitalization. Conclusions and Relevance Findings from this case-control study with a test-negative design involving children with a spectrum of influenza severity suggest that influenza vaccination protects children against all levels of severe influenza illness.
Shear Forces and the Vulnerability of the Podocyte
Authors: Josephine P. Briggs, Mark A. Knepper
Journal: Journal of the American Society of Nephrology (2024)

1Department of Medicine, University of Michigan, Ann Arbor, Michigan 2National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland Correspondence: Dr. Josephine P. Briggs, email: [email protected] See related article, "Numerical Flow Simulations of the Shear Stress Forces Arising in Filtration Slits during Glomerular Filtration in Rat Kidney," on pages XXX–XXX.
Podocyte-Mediated Protection from Kidney Injury
Authors: Sanna Lehtonen, Seppo Meri
Journal: Journal of the American Society of Nephrology (2024)

1Department of Pathology, University of Helsinki, Helsinki, Finland 2Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland 3Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland 4Translational Immunology Research Program, University of Helsinki, Helsinki, Finland 5Diagnostic Center, Helsinki University Hospital, Helsinki, Finland Correspondence: Prof. Sanna Lehtonen, email: [email protected] See related article, "Production of Acetylcholine by Podocytes and its Protection from Kidney Injury in GN," on pages XXX–XXX.
Reply to Aravindh Rathinam, Jonathan Katz, Robert Marcovich, and Hemendra N. Shah’s Letter to the Editor re: Michael Baboudjian, Hashim Hashim, Nikita Bhatt, et al. Summary Paper on Underactive Bladder from the European Association of Urology Guidelines on Non-neurogenic Male Lower Urinary Tract Symptoms. Eur Urol 2024;86:213–20
Authors: Michael Baboudjian, Massimiliano Creta, Hashim Hashim, Vasileios Sakalis, Jean-Nicolas Cornu
Journal: European Urology (2024)
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics
Authors: Chih-Chun Lee, Yu-Huei Huang, Ching-Chi Chi, Wen-Hung Chung, Chun-Bing Chen
Journal: Trends in Immunology (2024)

Generalized pustular psoriasis (GPP) is a rare human autoinflammatory disorder with life-threatening systemic effects. Keratinocyte-derived interleukin (IL)-36 signaling has been identified as a key mediator of immune response in the skin of affected individuals. Recognition of various mutations along the IL-36 axis and the downstream nuclear transcription factor κB (NF-κB) signaling have established GPP as genetically, immunologically, and histopathologically distinct and amenable to immunomodulation, which is epitomized by the recent success of IL-36 antagonism. This review covers recent discoveries of the genetic and immunological underpinnings of GPP, which have proved fertile ground for improving the quality of care of this clinically challenging and debilitating condition.
Multi-omic markers of Intraductal Papillary Mucinous Neoplasms progression into pancreatic cancer
Authors: Chiara Corradi, Manuel Gentiluomo, Volkan Adsay, Juan Sainz, Paolo Riccardo Camisa, Barbara Wlodarczyk, Stefano Crippa, Francesca Tavano, Gabriele Capurso, Daniele Campa
Journal: Seminars in Cancer Biology (2024)
Targeting m6A demethylase FTO to heal diabetic wounds with ROS-scavenging nanocolloidal hydrogels
Authors: Xinyao Zheng, Shaohui Deng, Yuan Li, Zhipeng Luo, Ziqi Gan, Zhaoping Zheng, Rui Xu, Shan Xiao, Yuxiong Cai, Jianfu Meng, Li Li, Changxing Li, Xiaowen Xue, Wei Dai, Si Qin, Mengying Wang, Kang Zeng, Zecong Xiao, Laixin Xia
Journal: Biomaterials (2024)
Skin microbiome and polymorphous light eruption
Authors: Vijaykumar Patra, Peter Wolf
Journal: British Journal of Dermatology (2024)

Journal Article Accepted manuscript Skin microbiome and polymorphous light eruption Get access Vijaykumar Patra, Vijaykumar Patra Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria Search for other works by this author on: Oxford Academic Google Scholar Peter Wolf Peter Wolf Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria Correspondence: Peter Wolf, Email:[email protected] Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, ljae513, https://doi.org/10.1093/bjd/ljae513 Published: 26 December 2024 Article history Received: 23 December 2024 Accepted: 24 December 2024 Published: 26 December 2024
The inconsistent terminology for the extent of resection in glioblastoma: A systematic review on 6 decades of neuro-oncological studies
Authors: Nina C Teske, Leonard B Jung, Nico Teske, Niklas Thon, Jörg-Christian Tonn, Philipp Karschnia
Journal: Neuro-Oncology (2024)

Journal Article Corrected proof The inconsistent terminology for the extent of resection in glioblastoma: A systematic review on 6 decades of neuro-oncological studies Get access Nina C Teske, Nina C Teske Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, Germany https://orcid.org/0009-0008-1200-745X Search for other works by this author on: Oxford Academic PubMed Google Scholar Leonard B Jung, Leonard B Jung Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Nico Teske, Nico Teske Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, GermanyDepartment of Neurosurgery, FAU University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Niklas Thon, Niklas Thon Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Jörg-Christian Tonn, Jörg-Christian Tonn Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Philipp Karschnia Philipp Karschnia Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Partner Site Munich, GermanyDepartment of Neurosurgery, FAU University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany Corresponding Author: Philipp Karschnia, MD (Priv.-Doz. Dr.), Department of Neurosurgery, Friedrich-Alexander-University Erlangen-Nuremberg, Schwabachanlage 6, Erlangen 91054, Germany ([email protected]). https://orcid.org/0000-0002-1254-5310 Search for other works by this author on: Oxford Academic PubMed Google Scholar Neuro-Oncology, noae254, https://doi.org/10.1093/neuonc/noae254 Published: 26 December 2024 Article history Corrected and typeset: 26 December 2024 Published: 26 December 2024
Association between gut microbiome profiles and host metabolic health across the life course: a population-based study
Authors: Ruolin Li, Alexander Kurilshikov, Shuyue Yang, Julie A E van Oortmerssen, Arno van Hilten, Fariba Ahmadizar, Gennady Roshchupkin, Robert Kraaij, Liesbeth Duijts, Jingyuan Fu, M Kamran Ikram, Vincent W V Jaddoe, André G Uitterlinden, Fernando Rivadeneira, Maryam Kavousi, Alexandra Zhernakova, Carolina Medina-Gomez
Journal: The Lancet Regional Health - Europe (2024)
Syndromic Retinitis Pigmentosa
Authors: Jessica S Karuntu, Hind Almushattat, Xuan-Thanh-An Nguyen, Astrid S Plomp, Ronald J A Wanders, Carel B Hoyng, Mary J van Schooneveld, Nicoline E Schalij-Delfos, Marion M Brands, Bart P Leroy, Clara D M van Karnebeek, Arthur A Bergen, Maria M van Genderen, Camiel J F Boon
Journal: Progress in Retinal and Eye Research (2024)
Multi-stain deep learning prediction model of treatment response in lupus nephritis based on renal histopathology
Authors: Cheng Cheng, Bin Li, Jie Li, Yiqin Wang, Han Xiao, Xingji Lian, Lizhi Chen, Junxian Wang, Haiyan Wang, Shuguang Qin, Li Yu, Tingbo Wu, Sui Peng, Weiping Tan, Qing Ye, Wei Chen, Xiaoyun Jiang
Journal: Kidney International (2024)
Population pharmacokinetics and dosing simulations of temocillin in liver transplanted paediatric patients: a prospective, open-label, non-randomized study
Authors: Perrin Ngougni Pokem, Xavier Stéphenne, Xin Liu, Suzanne L Parker, Dimitri Van der Linden, Marie-Laura Godet, Gert-Jan Wijnant, Olga Chatzis, Laurent Houtekie, Astrid Haenecour, Etienne Sokal, Jason A Roberts, Laure Elens, Françoise Van Bambeke
Journal: Clinical Microbiology and Infection (2024)
Resazurin dye is an in vivo sensor of kidney tubular function.
Authors: Shirely Acosta Martinez, Isaac Z Karel, Josie A Silvaroli, Eman Ahmed, Ji Young Kim, Amanda Stayton, Prisha S Patel, Mohammad Amir Afjal, Thomas Horton, Margaret Bohmer, Thitinee Vanichapol, Veronika Sander, Gabriel Mayoral Andrade, Corynne Vermillion Allison, Milon Mondal, Victoria C Thorson, Alexandra Partey, Kartik Nimkar, Victoria Williams, Jessica Quimby, Latha Ganesan, Sethu M Madhavan, Alan J Davidson, Blake R Peterson, Adebowale Adebiyi, Reena Rao, Douglas H Sweet, Prabhleen Singh, Kevin M Bennett, Diana Zepeda-Orozco, Sandeep K Mallipattu, Eric D Eisenmann, Alex Sparreboom, Brad H Rovin, Amandeep Bajwa, Navjot S Pabla
Journal: Kidney International (2024)
Optimizing Ewing Sarcoma and Osteosarcoma Biopsy Acquisition: A Children’s Oncology Group Bone Tumor Committee Consensus Statement
Authors: Matthew S. Dietz, Alyaa Al-Ibraheemi, Jessica L. Davis, C. Matthew Hawkins, Brian T. Craig, Roshni Dasgupta, David S. Geller, David S. Shulman, Sarah Cohen-Gogo, Ajay Gupta, Susan L. Whiteway, Emily K. Slotkin, Christine M. Heske, Safia K. Ahmed, Daniel J. Indelicato, Catherine M. Albert, Nicole Montgomery, Jesse K. Sandberg, Holcombe E. Grier, Mark Krailo, Michael S. Isakoff, Elyssa Rubin, Elizabeth R. Lawlor, Steven G. DuBois, Leo Mascarenhas, Patrick J. Grohar, Odion Binitie, Damon Reed, Katherine Janeway, Ryan D. Roberts, Kelly M. Bailey
Journal: Journal of the National Comprehensive Cancer Network (2024)

Trends in diagnostic biopsy sample collection approaches for primary bone sarcomas have shifted in the past 2 decades. Although open/incisional biopsies used to be the predominant approach to obtain diagnostic material for Ewing sarcoma and osteosarcoma, image-guided core needle biopsies have increased in frequency and are safe for patients. These procedures are less invasive and reduce recovery times but have potential limitations. The quantity and quality of tissue obtained through these procedures vary between institutions. Acquired viable tissue volumes can be low, limiting the conduct of downstream expanded clinical workup, molecular analyses, and research. Patients with advanced Ewing sarcoma and osteosarcoma continue to have overall poor outcomes despite dose-intensive cytotoxic chemotherapy. The biology of treatment resistance is not currently well understood, partly due to limited availability of relevant tissue to study. There is a need for access to quality tumor specimens for molecular and other analyses to identify high-risk tumor subsets and drive discovery to improve patient outcomes. Given broad variability in bone tumor tissue procurement and processing across member institutions, the Children’s Oncology Group Bone Tumor Committee convened a multidisciplinary group of experts to outline the current and near-future tissue needs for optimal clinical care and access to research platforms. The goal of this working group was to provide high-level guidance on biopsy practices that safely meet these evolving needs. Harmonizing tissue collection practices is paramount to improving the care of children, adolescents, and young adults diagnosed with Ewing sarcoma and osteosarcoma.