tbuckley/cabot-search huggingface dataset:
FES Effect on Muscle Fatigue based on Fatigue Characteristic Curve of Dumbbell Weight Training
Authors: Shihao Sun, Guizhi Xu, Mengfan Li, Mingyu Zhang, Yuxin Zhang, Wentao Liu, Alan Wang
Journal: Cyborg and Bionic Systems (2024)

The parameter setting of functional electrical stimulation (FES) is important for active recovery training since it affects muscle health. Among the FES parameters, current amplitude is the most influential factor. To explore the FES effect on the maximum stimulation time, this study establishes a curve between FES current amplitude and the maximum stimulation time based on muscle fatigue. We collect 10 subjects' surface electromyography under dumbbell weightlifting training and analyze the muscle fatigue state by calculating the root mean square (RMS) of power. By analyzing signal RMS, the fatigue characteristic curves under different fatigue levels are obtained. According to the muscle response under FES, the relationship curve between the current amplitude and the maximum stimulation time is established and FES parameters' effect on the maximum stimulation time is obtained. The linear curve provides a reference for FES parameter setting, which can help to set stimulation time safely, thus preventing the muscles from entering an excessive fatigue state and becoming more active to muscle recovery training.
Microelectrode Arrays for Detection of Neural Activity in Depressed Rats: Enhanced Theta Activity in the Basolateral Amygdala
Authors: Fanli Kong, Zhaojie Xu, Gucheng Yang, Qianli Jia, Fan Mo, Luyi Jing, Jinping Luo, Hongyan Jin, Xinxia Cai
Journal: Cyborg and Bionic Systems (2024)

Depression is a common and severely debilitating neuropsychiatric disorder. Multiple studies indicate a strong correlation between the occurrence of immunological inflammation and the presence of depression. The basolateral amygdala (BLA) is crucial in the cognitive and physiological processing and control of emotion. However, due to the lack of detection tools, the neural activity of the BLA during depression is not well understood. In this study, a microelectrode array (MEA) based on the shape and anatomical location of the BLA in the brain was designed and manufactured. Rats were injected with lipopolysaccharide (LPS) for 7 consecutive days to induce depressive behavior. We used the MEA to detect neural activity in the BLA before modeling, during modeling, and after LPS administration on 7 consecutive days. The results showed that after LPS treatment, the spike firing of neurons in the BLA region of rats gradually became more intense, and the local field potential power also increased progressively. Further analysis revealed that after LPS administration, the spike firing of BLA neurons was predominantly in the theta rhythm, with obvious periodic firing characteristics appearing after the 7 d of LPS administration, and the relative power of the local field potential in the theta band also significantly increased. In summary, our results suggest that the enhanced activity of BLA neurons in the theta band is related to the depressive state of rats, providing valuable guidance for research into the neural mechanisms of depression.
High-throughput microelectrode arrays for functional localization of the globus pallidus internus
Authors: Yuxin Zhu, Luyi Jing, Ruilin Hu, Fan Mo, Qianli Jia, Gucheng Yang, Zhaojie Xu, Meiqi Han, Mixia Wang, Xinxia Cai, Jinping Luo
Journal: Cyborg and Bionic Systems (2024)

The globus pallidus internus (GPi) was considered a common target for stimulation in Parkinson’s disease (PD). Located deep in the brain and of small size, pinpointing it during surgery is challenging. Multi-channel microelectrode arrays (MEAs) can provide micrometer-level precision functional localization, which can maximize the surgical outcome. In this paper, a 64-channel MEA modified by platinum nanoparticles with a detection site impedance of 61.1 kΩ was designed and prepared, and multiple channels could be synchronized to cover the target brain region and its neighboring regions so that the GPi could be identified quickly and accurately. The results of the implant trajectory indicate that, compared to the control side, there is a reduction in local field potential (LFP) power in multiple subregions of the upper central thalamus on the PD-induced side, while the remaining brain regions exhibit an increasing trend. When the MEA tip was positioned at 8,700 μm deep in the brain, the various characterizations of the spike signals, combined with the electrophysiological characteristics of the β-segmental oscillations in PD, enabled MEAs to localize the GPi at the single-cell level. More precise localization could be achieved by utilizing the distinct characteristics of the internal capsule (ic), the thalamic reticular nucleus (Rt), and the peduncular part of the lateral hypothalamus (PLH) brain regions, as well as the relative positions of these brain structures. The MEAs designed in this study provide a new detection method and tool for functional localization of PD targets and PD pathogenesis at the cellular level.
Nature‐Inspired Gelatin‐Based Adhesive Hydrogel: A Rapid and User‐Friendly Solution for Hemostatic Applications
Authors: Haihua Wang, Mengxi Wang, Jingheng Wu, Shilei Zhu, Yanan Ye, Yushan Liu, Ke Li, Ruyue Li, Yuhang Zhang, Meng Wei, Xin Yang, Leixin Meng
Journal: Advanced Healthcare Materials (2024)

Conventional hemostatic agents face challenges in achieving rapid hemostasis and effective tissue repair due to limited hemostatic scenarios, suboptimal efficacy, and inadequate adhesion to wet tissues. Drawing inspiration from nature-sourced materials, a gelatin-based adhesive hydrogel (AOT) is designed, easily prepared and quick to form, driven by Schiff base and multiple hydrogen bonds for applications in arterial and liver bleeding models. AOT exhibits exceptional adhesion to wet tissues (48.67 ± 0.16 kPa) and displays superior hemostatic properties with reduced blood loss and hemostatic time compared to other hydrogels and conventional hemostatic materials. Moreover, AOT exhibits good biocompatibility and biodegradability. In summary, this easily prepared adhesive hydrogel has the potential to supplant traditional hemostatic agents, offering a novel approach to achieve swift sealing of hemostasis and facilitate wound healing and repair in broader application scenarios, owing to its unique advantages.
Endoscopic ultrasound-guided embolization of a gastric varix by injection of RADA16 self-assembling peptide and coils
Authors: Jonathan Wilen, Judy A Trieu, Todd H. Baron
Journal: Endoscopy (2024)

Gastric variceal bleeding accounts for 10%–30% of variceal bleeding and has higher mortality than esophageal variceal bleeding [1]. Endoscopic ultrasound (EUS) offers new modalities for treatment and prevention of gastric variceal bleeding. Acrylate polymers such as cyanoacrylate are traditionally injected into gastric varices under EUS guidance. However, adverse events, such as systemic embolization, ulceration with rebleeding, and failed withdrawal of the needle, are drawbacks to cyanoacrylate use. Coil embolization is more effective with fewer adverse events than cyanoacrylate injection and with high technical and clinical success [2]. The combination of cyanoacrylate and coil embolization appears more effective than monotherapy [3]. Because of the particular handling and side-effect profile of cyanoacrylate, alternative agents have been used for treatment of gastric varices [4]. We present the use of a novel hemostatic gel (PuraStat; 3-D Matrix, Newton, Massachusetts, USA) injected for treatment of gastric variceal bleeding. PuraStat is composed of 2.5% RADA16, a synthetic hemostatic material that forms a 3D matrix mimicking human extracellular matrix [5]. It has been used in a variety of clinical scenarios with promising results [5].
Interlimb and Intralimb Synergy Modeling for Lower Limb Assistive Devices
Authors: Fengyan Liang, Lifen Mo, Yiou Sun, Cheng Guo, Fei Gao, Wei-Hsin Liao, Junyi Cao, Binbin Li, Zhenhua Song, Dong Wang, Ming Yin
Journal: Cyborg and Bionic Systems (2024)

The concept of gait synergy provides novel human–machine interfaces and has been applied to the control of lower limb assistive devices, such as powered prostheses and exoskeletons. Specifically, on the basis of gait synergy, the assistive device can generate/predict the appropriate reference trajectories precisely for the affected or missing parts from the motions of sound parts of the patients. Optimal modeling for gait synergy methods that involves optimal combinations of features (inputs) is required to achieve synergic trajectories that improve human–machine interaction. However, previous studies lack thorough discussions on the optimal methods for synergy modeling. In addition, feature selection (FS) that is crucial for reducing data dimensionality and improving modeling quality has often been neglected in previous studies. Here, we comprehensively investigated modeling methods and FS using 4 up-to-date neural networks: sequence-to-sequence (Seq2Seq), long short-term memory (LSTM), recurrent neural network (RNN), and gated recurrent unit (GRU). We also conducted complete FS using 3 commonly used methods: random forest, information gain, and Pearson correlation. Our findings reveal that Seq2Seq (mean absolute error: 0.404° and 0.596°, respectively) outperforms LSTM, RNN, and GRU for both interlimb and intralimb synergy modeling. Furthermore, FS is proven to significantly improve Seq2Seq’s modeling performance ( P &lt; 0.05). FS-Seq2Seq even outperforms methods used in existing studies. Therefore, we propose FS-Seq2Seq as a 2-stage strategy for gait synergy modeling in lower limb assistive devices with the aim of achieving synergic and user-adaptive trajectories that improve human–machine interactions.
mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
Authors: Brian Montoya, Carolina R Melo-Silva, Lingjuan Tang, Samita Kafle, Peter Lidskiy, Csaba Bajusz, Máté Vadovics, Hiromi Muramatsu, Edit Abraham, Zoltan Lipinszki, Debotri Chatterjee, Gabrielle Scher, Juliana Benitez, Molly M H Sung, Ying K Tam, Nicholas J Catanzaro, Alexandra Schäfer, Raul Andino, Ralph S Baric, David R Martinez, Norbert Pardi, Luis J Sigal
Journal: Molecular Therapy (2024)

The role of CD8
Influence of artificial intelligence on the diagnostic performance of endoscopists in the assessment of Barrett’s esophagus: a tandem randomized and video trial
Authors: Michael Meinikheim, Robert Mendel, Christoph Palm, Andreas Probst, Anna Muzalyova, Markus W. Scheppach, Sandra Nagl, Elisabeth Schnoy, Christoph Römmele, Dominik A. H. Schulz, Jakob Schlottmann, Friederike Prinz, David Rauber, Tobias Rückert, Tomoaki Matsumura, Glòria Fernández-Esparrach, Nasim Parsa, Michael F. Byrne, Helmut Messmann, Alanna Ebigbo
Journal: Endoscopy (2024)

This study evaluated the effect of an artificial intelligence (AI)-based clinical decision support system on the performance and diagnostic confidence of endoscopists in their assessment of Barrett's esophagus (BE).
Airway clearance management in people with bronchiectasis: data from the European Bronchiectasis Registry (EMBARC)
Authors: Arietta Spinou, Beatriz Hererro-Cortina, Stefano Aliberti, Pieter C. Goeminne, Eva Polverino, Katerina Dimakou, Charles S. Haworth, Michael R. Loebinger, Anthony De Soyza, Montserrat Vendrell, Pierre Regis Burgel, Melissa McDonnell, Sivagurunathan Sutharsan, Sabina Škrgat, Luiz Maiz-Carro, Oriol Sibila, Daiana Stolz, Paula Kauppi, Apostolos Bossios, Adam T. Hill, Ian Clifton, Megan L. Crichton, Paul Walker, Rosario Menendez, Sermin Borekci, Dusanka Obradovic, Adam Nowinski, Adelina Amorim, Antoni Torres, Natalie Lorent, Tobias Welte, Francesco Blasi, Mateja Jankovic Makek, Michal Shteinberg, Wim Boersma, J. Stuart Elborn, James D. Chalmers, Felix C. Ringshausen
Journal: European Respiratory Journal (2024)

Background International guidelines recommend airway clearance management as one of the important pillars of bronchiectasis treatment. However, the extent to which airway clearance is used for people with bronchiectasis in Europe is unclear. The aim of the study was to identify the use of airway clearance management in patients with bronchiectasis across different countries and factors influencing airway clearance use. Methods This was a prospective observational study using data from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) Registry between January 2015 and April 2022. Prespecified options for airway clearance management were recorded, including airway clearance techniques, devices and use of mucoactive drugs. Results 16 723 people with bronchiectasis from 28 countries were included in the study. The mean age was 67 years (interquartile range 57–74 years, range 18–100 years) and 61% were female. 72% of the participants reported daily sputum expectoration and 52% (95% CI 51–53%) of all participants reported using regular airway clearance management. Active cycle of breathing technique was used by 28% of the participants and airway clearance devices by 16% of participants. The frequency of airway clearance management and techniques used varied significantly between different countries. Participants who used airway clearance management had greater disease severity and worse symptoms, including a higher daily sputum volume, compared to those who did not use it regularly. Mucoactive drugs were also more likely to be used in participants with more severe disease. Access to specialist respiratory physiotherapy was low throughout Europe, but particularly low in Eastern Europe. Conclusions Only a half of people with bronchiectasis in Europe use airway clearance management. Use of and access to devices, mucoactive drugs and specialist chest physiotherapy appears to be limited in many European countries.
Objective sputum colour assessment and clinical outcomes in bronchiectasis: data from the European Bronchiectasis Registry (EMBARC)
Authors: Stefano Aliberti, Felix C. Ringshausen, Raja Dhar, Charles S. Haworth, Michael R. Loebinger, Katerina Dimakou, Megan L. Crichton, Anthony De Soyza, Montse Vendrell, Pierre-Regis Burgel, Melissa McDonnell, Sabina Skrgat, Luis Maiz Carro, Andres de Roux, Oriol Sibila, Apostolos Bossios, Menno van der Eerden, Paula Kauppi, Robert Wilson, Branislava Milenkovic, Rosario Menendez, Marlene Murris, Sermin Borekci, Oxana Munteanu, Dusanka Obradovic, Adam Nowinski, Adelina Amorim, Antoni Torres, Natalie Lorent, Eva Van Braeckel, Josje Altenburg, Amelia Shoemark, Michal Shteinberg, Wim Boersma, Pieter C. Goeminne, J. Stuart Elborn, Adam T. Hill, Tobias Welte, Francesco Blasi, Eva Polverino, James D. Chalmers
Journal: European Respiratory Journal (2024)

Background A validated 4-point sputum colour chart can be used to objectively evaluate the levels of airway inflammation in bronchiectasis patients. In the European Bronchiectasis Registry (EMBARC), we tested whether sputum colour would be associated with disease severity and clinical outcomes. Methods We used a prospective, observational registry of adults with bronchiectasis conducted in 31 countries. Patients who did not produce spontaneous sputum were excluded from the analysis. The Murray sputum colour chart was used at baseline and at follow-up visits. Key outcomes were frequency of exacerbations, hospitalisations for severe exacerbations and mortality during up to 5-year follow-up. Results 13 484 patients were included in the analysis. More purulent sputum was associated with lower forced expiratory volume in 1 s (FEV 1 ), worse quality of life, greater bacterial infection and a higher bronchiectasis severity index. Sputum colour was strongly associated with the risk of future exacerbations during follow-up. Compared to patients with mucoid sputum (reference group), patients with mucopurulent sputum experienced significantly more exacerbations (incident rate ratio (IRR) 1.29, 95% CI 1.22–1.38; p&lt;0.0001), while the rates were even higher for patients with purulent (IRR 1.55, 95% CI 1.44–1.67; p&lt;0.0001) and severely purulent sputum (IRR 1.91, 95% CI 1.52–2.39; p&lt;0.0001). Hospitalisations for severe exacerbations were also associated with increasing sputum colour with rate ratios, compared to patients with mucoid sputum, of 1.41 (95% CI 1.29–1.56; p&lt;0.0001), 1.98 (95% CI 1.77–2.21; p&lt;0.0001) and 3.05 (95% CI 2.25–4.14; p&lt;0.0001) for mucopurulent, purulent and severely purulent sputum, respectively. Mortality was significantly increased with increasing sputum purulence, hazard ratio 1.12 (95% CI 1.01–1.24; p=0.027), for each increment in sputum purulence. Conclusion Sputum colour is a simple marker of disease severity and future risk of exacerbations, severe exacerbations and mortality in patients with bronchiectasis.
Three-dimensional printing-assisted interventional therapy for thoracogastric right main bronchial fistula
Authors: Zhen Li, Yifan Li, Zongming Li, Huibin Lu, Xin Li, Xinwei Han, Kewei Ren
Journal: Endoscopy (2024)

Based on 3D printed models, the size, location, and morphology of thoracogastric airway fistulas can be more accurately assessed, which can help physicians better determine the size and location of stents or occluders [1].
Correction: A rare case of endoscopic full-thickness resection of a laterally spreading tumor at the anastomotic site of appendectomy
Authors: Yinong Zhu, Wei Liu, Bing Hu
Journal: Endoscopy (2024)

Correction to: A rare case of endoscopic full-thickness resection of a laterally spreading tumor at the anastomotic site of appendectomyEndoscopy 2024; 56(S 01): E199-E200DOI: 10.1055/a-2248-0579
Correction:<i>Identification of c-FLIPL and c-FLIPS as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells</i>
Journal: Gut (2024)

Figure 9a illustrates the downregulation of c-FLIP by Cisplatin.The authors observed that while five Western Blot lanes depict the effect of increasing Cisplatin concentrations on c-FLIP protein, six lanes are presented for the loading control beta-Actin.Thus, the 6th lane of the loading control beta-Actin has unintentionally been included in Figure 9a.
Cannabis smoking is associated with advanced epigenetic age
Authors: Ana I. Hernandez Cordero, Xuan Li, Chen Xi Yang, Amirtha Ambalavanan, Julie L. MacIsaac, Michael S. Kobor, Dany Doiron, Wan Tan, Jean Bourbeau, Don D. Sin, Qingling Duan, Janice M. Leung
Journal: European Respiratory Journal (2024)

Cannabis use has been controversial, largely having been designated a controlled substance over the last century. While certain studies have linked cannabis smoking with harmful effects such as increased respiratory symptoms and faster lung function decline in older adults [1, 2], these findings have not been fully replicated by others [3]. The link between cannabis and disease pathogenesis may best be explored through DNA methylation. This mechanism consists of the addition or removal of a methyl group at a cytosine-guanine residue (CpG), can be influenced by exposures, and can modify transcription. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article. Conflicts of Interests: None reported by any of the authors.
The carbon footprint of as-needed budesonide/formoterol in mild asthma: a<i>post hoc</i>analysis
Authors: Lee Hatter, Mark Holliday, Allie Eathorne, Pepa Bruce, Ian D. Pavord, Helen K. Reddel, Robert J. Hancox, Alberto Papi, Mark Weatherall, Richard Beasley
Journal: European Respiratory Journal (2024)

Introduction The use of pressurised metered-dose inhalers (pMDIs) and asthma exacerbations necessitating healthcare reviews contribute substantially to the global carbon footprint of healthcare. It is possible that a reduction in carbon footprint could be achieved by switching patients with mild asthma from salbutamol pMDI reliever-based therapy to inhaled corticosteroid-formoterol dry powder inhaler (DPI) reliever therapy, as recommended by the Global Initiative for Asthma. Methods This post hoc analysis included all 668 adult participants in the Novel START trial, who were randomised 1:1:1 to treatment with as-needed budesonide/formoterol DPI, as-needed salbutamol pMDI or maintenance budesonide DPI plus as-needed salbutamol pMDI. The primary outcome was carbon footprint of asthma management, expressed as kilograms of carbon dioxide equivalent emissions (kgCO 2 e) per person-year. Secondary outcomes explored the effect of baseline symptom control and adherence (maintenance budesonide DPI arm only) on carbon footprint. Results As-needed budesonide/formoterol DPI was associated with 95.8% and 93.6% lower carbon footprint compared with as-needed salbutamol pMDI (least-squares mean 1.1 versus 26.2 kgCO 2 e; difference −25.0, 95% CI −29.7 to −20.4; p&lt;0.001) and maintenance budesonide DPI plus as-needed salbutamol pMDI (least-squares mean 1.1 versus 17.3 kgCO 2 e; difference −16.2, 95% CI −20.9 to −11.6; p&lt;0.001), respectively. There was no statistically significant evidence that treatment differences in carbon footprint depended on baseline symptom control or adherence in the maintenance budesonide DPI arm. Conclusions The as-needed budesonide/formoterol DPI treatment option was associated with a markedly lower carbon footprint than as-needed salbutamol pMDI and maintenance budesonide DPI plus as-needed salbutamol pMDI.
Fluorescence in situ hybridization reveals the evolutionary biology of minor clone of gain/amp(1q) in multiple myeloma
Authors: Jian Cui, Yuntong Liu, Rui Lv, Wenqiang Yan, Jingyu Xu, Lingna Li, Chenxing Du, Tengteng Yu, Shuaishuai Zhang, Shuhui Deng, Weiwei Sui, Mu Hao, Shuhua Yi, Dehui Zou, Lugui Qiu, Yan Xu, Gang An
Journal: Leukemia (2024)

Abstract Growing evidence suggests that gain or amplification [gain/amp(1q)] accumulates during disease progression of multiple myeloma (MM). Previous investigations have indicated that small gain/amp(1q) subclones present at the time of diagnosis may evolve into dominant clones upon MM relapse. However, the influence of a minor clone of gain/amp(1q) on MM survival, as well as the correlation between different clonal sizes of gain/amp(1q) and the chromosomal instability (CIN) of MM, remains poorly understood. In this study, we analyzed fluorescence in situ hybridization (FISH) results of 998 newly diagnosed MM (NDMM) patients. 513 patients were detected with gain/amp(1q) at diagnosis. Among these 513 patients, 55 had a minor clone (≤20%) of gain/amp(1q). Patients with a minor clone of gain/amp(1q) displayed similar survival outcomes compared to those without gain/amp(1q). Further analysis demonstrated patients with a minor clone of gain/amp(1q) exhibited a clonal architecture similar to those without gain/amp(1q). Lastly, our results showed a significant increase in the clonal size of the minor clone of gain/amp(1q), frequently observed in MM. These findings suggested that a minor clone of gain/amp(1q) might represent an earlier stage in the pathogenesis of gain/amp(1q) and propose a “two-step” process in the clonal size changes of gain/amp(1q) in MM.