tbuckley/cabot-search huggingface dataset:
SCOT: Short Course Oncology Therapy—A comparison of 12 and 24 weeks of adjuvant chemotherapy in colorectal cancer.
Authors: J. Paul, A. Briggs, A. Harkin, A. M. Haydon, T. Iveson, M. Masterson, R. A. Midgley, J. Cassidy
Journal: Journal of Clinical Oncology (2011)

e14145 Background: Colorectal cancer is one of the leading causes of cancer mortality worldwide. Many large randomized clinical trials have established a benefit for adjuvant 5-fluorouracil (5-FU) based chemotherapy in this disease. More recently the NSABP C-07 and MOSAIC trials have shown a benefit for the addition of oxaliplatin to adjuvant treatment, but this has also led to increased toxicity (Kuebler JP, Wieand HS, O'Connell MJ, et al. J Clin Oncol. 2007;25:2198-2204; Andre T, Boni C, Mounedji-Boudiaf L, et al. N Engl J Med. 2004;350:2343-2351.). This is an important issue for a population of patients in whom a proportion will be cured of their disease by surgery alone. Currently the standard treatment duration for adjuvant chemotherapy for colorectal cancer is 24 weeks. One way to address the important issues of increasing toxicity and cost would be to shorten treatment. The SCOT study aims to ascertain whether 12 weeks of treatment is as efficacious as 24 weeks. Methods: SCOT is a randomised non-inferiority study comparing 12 and 24 weeks of adjuvant treatment. The primary end-point is disease free survival (DFS) and the study is designed to exclude a maximum 2.5% fall in 3-year DFS on the 12 week arm with 90% power at the 2.5% 1-sided level of statistical significance. This requires 9,500 patients recruited over 5 years with minimum subsequent follow-up of 2 years. Secondary end-points are cost-effectiveness, survival, quality of life and toxicity. Patients with fully resected fully resected stage III/high risk stage II colorectal cancer are eligible for SCOT. Participating sites can select either oxaliplatin/capecitabine (q3/52) or oxaliplatin/5FU (q2/52) for each individual patient prior to randomization. Results: UK enrollment began in May 2008 and currently 1,917 patients are on study. Australasia is participating, shortly to be joined by Denmark and Spain. Conclusions: The study will contribute to the IDEA collaboration (International Duration Evaluation of Adjuvant Chemotherapy – secretariat Daniel Sargent/Axel Grothey) which is a planned prospective analysis of several studies (currently from USA, France and Italy) looking at the question of treatment duration in stage III colon cancer.
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Idelalisib and Rituximab for Previously Treated Patients with Chronic Lymphocytic Leukemia (CLL)
Authors: Richard R. Furman, Jeff P. Sharman, Steven E. Coutre, Bruce D. Cheson, John M. Pagel, Peter Hillmen, Jacqueline C. Barrientos, Andrew D. Zelenetz, Thomas J. Kipps, Ian Flinn, Paolo Ghia, Herbert Eradat, Thomas Ervin, Nicole Lamanna, Michael Hallek, Bertrand Coiffier, Andrew R. Pettitt, Shuo Ma, Stephan Stilgenbauer, Paula Cramer, Maria Aiello, Dave M. Johnson, Langdon L. Miller, Daniel Li, Thomas M. Jahn, Roger D. Dansey, Susan M. O'Brien
Journal: Blood (2013)
Abstract 15212: Reduction in Radiation Exposure Rate During Transradial Catheterization and Intervention Using a Simple Lead Drape
Authors: Ali F Iqtidar, Randall Snead, Richard Rothman, Cathy Jeon, Kevin Dwyer, Christopher Pyne
Journal: Circulation (2011)

Background: Transradial access for cardiac catheterization and intervention reduces vascular access complications and improves outcomes in certain patient groups, but concerns persist over operator...
Abstract 14715: The Efficacy and Safety of New Strategy for Refractory Kawasaki Disease: A Clinical Trial in Single Institution
Authors: Masahiro Ishii, Shohei Ogata, Takashi Honda, Yoshihito Ogihara, Sumito Kimura, Yayoi Nakahata
Journal: Circulation (2010)

Background: Approximately 15-20% of patients with Kawasaki disease (KD) are not responsive to intravenous immunoglobulin (IVIG). This KD was defined as refractory KD. In these refractory KD patient...
Blood Clotting and Allied Problems: Transactions of the Fifth Conference, January 21 and 22, 1952, New York, New York.
Authors: Allied Problems, Joseph E. Flynn
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arnold Waterlow. A Life.
Authors: May Sinclair
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4027: Negative Hemodynamic Effects of Pantoprazole at High Infusion Rates in Mice
Authors: Bernhard Unsold, Nils Teucher, Michael Didie, Samuel Sosalla, Claudius Jacobshagen, Tim Seidler, Friedrich Schondube, Lars S Maier, Wolfgang Schillinger, Gerd Hasenfuss
Journal: Circulation (2009)
Alkylpurine-DNA glycosylase and alkylguanine-DNA alkyltransferase repair activity in peripheral blood mononuclear cell nuclei from lung cancer cases and cancer free controls
Authors: P A Crosbie, A Watson, G McGown, M R Thorncroft, R Agius, A C Povey, P V Barber, G P Margison
Journal: Thorax (2006)
Case 18-2015
Authors: Suzanne K. Freitag, Mary E. Cunnane, Michael K. Yoon, Jeffrey A. Barnes, Karen M. Winkfield, Aliyah R. Sohani
Journal: New England Journal of Medicine (2015)

A 41-year-old woman presented with decreased visual acuity in the left eye and diplopia. MRI of the head and orbits revealed abnormal soft tissue in the left sphenoid sinus and orbital apex, extending to the left cavernous sinus. A diagnostic procedure was performed.
Nature's Transplant. The Transplantation Immunology of Viviparity.
Authors: John Maxwell Anderson
Journal: Annals of Internal Medicine (1973)

Biology of the Academy of Sciences of the U.S.S.R., was to bring to American readers his own and other Russian work on the ability of mammalian organs to regenerate.He is careful to point out that limitations of space have meant a synoptic rather than a discusive presentation, and when allowance has been made for reference lists and illustrations, the text is certainly short.It deals only with limbs, skull bones, tooth tissues, heart muscle and nervous tissue.
CT-SYNTAX Score
Authors: Stella-Lida Papadopoulou, Chrysafios Girasis, Anoeshka Dharampal, Vasim Farooq, Yoshinobu Onuma, Alexia Rossi, Marie-angèle Morel, Gabriel P. Krestin, Patrick W. Serruys, Pim J. de Feyter, Hector M. Garcia Garcia
Journal: JACC. Cardiovascular imaging (2013)
Drug-Induced Anaphylaxis
Authors: 正治 村中
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Roundabout Harley Street: The Story of Some Famous Streets.
Authors: Cyril Phillips Bryan
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase III randomized, placebo-controlled trial of L-carnitine supplementation for fatigue in patients with cancer
Authors: R. A. Cruciani, J. Zhang, J. B. Manola, D. Cella, B. Ansari, M. J. Fisch
Journal: Journal of Clinical Oncology (2009)

e20532 Background: Carnitine deficiency has been reported in pts with cancer. This study was done to determine the prevalence of carnitine deficiency and the impact of supplementation on fatigue. Methods: Between November 2005 and January 2007, 376 pts with an invasive malignancy and normal hemoglobin levels with fatigue assessed as moderate or severe (score of 2 or higher on “I feel fatigued” question on FACIT-F) within 4 wks were randomized to 4 wks of supplementation with oral carnitine (n=189) or placebo (n=187) 1000 mg twice daily with meals. All pts then received 4 wks of open-label carnitine. Pts were stratified on gender, performance status (PS), and current receipt of chemotherapy. Quality of life was assessed at baseline, wk 4, and wk 8. The study was designed to detect a difference of 0.5 standard deviations in the change of average daily fatigue between the arms at 4 wks using the Brief Fatigue Index (BFI). Results: More than half of pts were male, had metastatic disease and were currently receiving chemotherapy. At study entry, 15% had ECOG PS 2–3, 39% were taking analgesics and 28% were taking antidepressants. There was no difference in the change in scores from baseline to wk 4 on the BFI, FACIT-F, Brief Pain Index (BPI) severity, BPI interference, or CES-D between arms (Wilcoxon p=0.56, 0.62, 0.61, .64, 0.93, respectively). The proportion of pts with severe fatigue or significant depression declined over time on both arms. Carnitine deficiency was defined using the acyl:free carnitine ratio and free carnitine levels. Deficiency levels were 34%, 11%, and 14% among pts randomized to carnitine and 32%, 33%, and 11% among pts randomized to placebo at baseline, wk 4, and wk 8, respectively (p&lt;0.001 at 4 wks). An exploratory analysis suggests an improvement among pts who were carnitine deficient at the beginning of supplementation. Conclusions: Carnitine supplementation reduced deficiency levels but did not have a significant effect on fatigue, pain or depression. Analyses of carnitine metabolites are ongoing. No significant financial relationships to disclose.
A New Portable Hybrid Camera for Fused Optical and Scintigraphic Imaging
Authors: Daan Hellingman, Sergi Vidal-Sicart, Linda J. de Wit-van der Veen, Pilar Paredes, Renato A. Valdés Olmos
Journal: Clinical Nuclear Medicine (2015)

Although portable gamma cameras (PGCs) have been helpful to depict sentinel nodes (SNs), sometimes nuclear physicians or surgeons have difficulties to interpret PGC images because of the lack of anatomical information. The aim of the present study was to develop and clinically test the prototype of a new portable hybrid camera (PHC), which adds optical to γ-imaging.In 2 hospitals, the existing PGC (Sentinella S102; Oncovision) was upgraded with an optical module (BB2-08S2C-25; Point Grey Research) to build a PHC. Preoperative PHC overview images (positioned at 15 cm distance) and close-up image (position at <5 cm distance) were obtained from 25 patients (12 melanoma, 2 oral cavity, and 11 breast cancer) after conventional lymphoscintigraphy. Errors in the optical image coregistration were evaluated with a 5-mm accuracy for each patient.Conventional lymphoscintigraphy and the close-up PHC images depicted 55 SNs in total. In the PHC overview images, the optical module offered fused optical and γ-imaging indicating the image field of view and anatomical SN locations. Average optical image coregistration errors were 1.0 cm (range, 0-2.0 cm).Fused optical and γ-imaging with the prototype PHC is technically feasible and helpful for the image interpretation. The optical image visualizes the γ-image field of view, enabling SN localization in an anatomical context in a preoperative setting; however, for the operating room, the use of its optical component needs to be additionally adjusted.
Vasopressin: Disturbed Secretion and Its Effects
Authors: L. Kovács, Branislav Lichardus, Milan Erban
Journal: Annals of Internal Medicine (1990)

A synthesis of recent advances covering the hormone's physiology, pathophysiology, and clinical use in children, adults, and the elderly. The largest part of the book is devoted to clinical questions relating to hypo- and hypervasopressinism. Covers problems encountered in the practice of fluid ther
La tuberculose du lobe azygos.
Authors: B. Le Bourdellès, Jalet. J.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Novel Hybrids of Hydroxyurea and Thalidomide Based Pharmacophores Induce Fetal Hemoglobin and Block Monocyte Activation
Authors: Carolina Lanaro, Carla Franco-Penteado, Jean Leandro Santos, Marlene Wade, Shobha Yerigenahally, Sheley Gambero, Lidia Moreira Lima, Chung Man Chin, Abdullah Kutlar, Fernando Ferreira Costa, Steffen E. Meiler
Journal: Blood (2010)
Abstract 18057: Impact of Elevated Peripheral Chemosensitivity on Spontaneous Baroreflex Function in Chronic Heart Failure Patients with Cardiorenal Anaemia Syndrome
Authors: Fabien Despas, Nicolas Franchitto, Michel Galinier, Jean-Michel Senard, Atul Pathak
Journal: Circulation (2011)

Objective Cardiorenal anaemia syndrome is known to increase mortality and morbidity in patients with CHF. The role of the sympathetic nervous system and related-reflexes in the pathophysiology remains unknown. Design and Methods The prospective study was conducted at the Intensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, France. We studied 15 patients with CRA syndrome (age: 66.5 ± 3.1 years; mean BMI: 24.12 ± 0.9 kg/m 2 ) and 15 control patients with CHF alone matched for age, gender distribution, type of cardiomyopathy, left ventricular ejection fraction (LVEF) and BMI. We compared sympathetic nerve activity (MSNA), sympathetic baroreflex function (assessed by the slope of the relationship between muscle sympathetic nerve activity (MSNA) and diastolic blood pressure) and its modulation by peripheral chemoreflex, in both groups. Results Baseline MSNA was significantly elevated in CHF patients with CRA syndrome compared with patients with CHF alone (83.1 ± 4.6 versus 64.9 ± 2.9 bursts/100 heart beats; P &lt;0.01) and sympathetic baroreflex function impaired (2.69 ± 0.44 versus 5.25 ± 0.60 %/mmHg; P &lt;0.01). In comparaison with control, chemoreflex deactivation with administration of 100% oxygen led to a significant decrease in muscle sympathetic nerve activity and an increase in arterial baroreflex sensitivity in patients with CRA syndrome. Conclusion CRA syndrome is associated with elevated sympathetic activity mediated by both baroreflex impairment and tonic activation of peripheral chemoreflex. The latter, through direct interaction with sympathetic baroreflex function subsequently contributes to further activation of the SNS tone. Altogether, mechanisms described in this study could partly explain how CRAS contributes to the progression of CHF and increases morbidity and mortality in these patients.
Practical Obstetrics for Students and Practitioners.
Authors: P. Brooke Bland, Thaddeus Lemert Montgomery
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Administration of tetradecylthioacetic acid (TTA) stimulates myocardial fatty acid oxidation despite having a lipid-lowering effect
Authors: DL Severson, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Kieran Clarke, Martin Hagve, Rolf Berge, trine Lund, Terje Larsen, Ellen Aasum
Journal: Cardiovascular Research (2009)

This is the submitted version of the article, later published with altered title in Cardiovascular Research.
 The article is part of Khalid's doctoral thesis which is available at  http://hdl.handle.net/10037/1802
Abstract 2381: Socioeconomic Status is Associated with Increased Morbidity in Patients Enrolled in a Dedicated Heart Failure Program
Authors: Jane T Luu, Christopher P Gans, Paymon Mesgarzadeh, Thomas Stamos, John A Kao
Journal: Circulation (2008)

Despite continued advances in medicine, the NIH has reported that differences in the incidence, prevalence, and burden of diseases persist between socioeconomic classes. Heart failure (HF) is the leading cause of hospitalizations in all patients over the age of 65. The effect of socioeconomic disparities on this major cause of morbidity has not been well studied. A retrospective analysis was performed on 500 patients with heart failure followed in the University of Illinois-Chicago heart failure clinic from 1/1/2000 –1/1/2008. Patients were stratified by household income and education level by correlating patient zip codes with the 2000 U.S. Census Data. The primary endpoint was admission for HF exacerbation. In patients with established HF, patients living in areas with lower median household incomes were significantly more likely to have a HF exacerbation (P = 0.006), as well as an increase in total exacerbations (P = 0.005) through an average follow up period of 5.2 years. The same trend was observed when areas were stratified according to the percentage of population with bachelor’s degrees. Overall, baseline characteristics were similar between groups. Significant differences by household income and education level were found in hypertension, presence of coronary artery disease and medication use (Tables 1 and 2 ). Despite uniform treatment according to ACC/AHA guidelines, socioeconomic disparities were associated with increased morbidity in patients established in a dedicated heart failure program. Further studies are needed to address these disparities. Heart Failure Outcomes by Median Household Income Heart Failure Outcomes by Education