tbuckley/cabot-search huggingface dataset:
Pemetrexed in the treatment of Asian patients with non-small cell lung cancer (NSCLC) and mesothelioma: Experience at the Johns Hopkins Singapore International Medical Centre
Authors: G. Lopes, J. Kukutschka, P. Portillo, E. H. Lim, L. Bharwani, W. Hsieh, A. Y. Chang
Journal: Journal of Clinical Oncology (2008)

20662 Background: The efficacy and toxicity of Pemetrexed (P) in Asian patients is unknown. Methods: Retrospective review of patients treated with P in a single institution between July 2005 and November 2007. Medical records, radiologic and laboratory data were reviewed. RECIST were used to assess efficacy independently of the treating physician’s assessment. National Cancer Institute CTCAE v3.0 were used for the description of adverse events. Results: Forty-three patients received P: 37 had NSCLC and 6 had mesothelioma. Patients with NSCLC had a median age of 60 years (range, 45 to 89), and were predominantly male (29 men and 8 women), ethnic Chinese (32 patients) and smokers (22 patients). Histology was as follows: NSCLC, 19; adenocarcinoma, 12; squamous cell carcinoma, 4; bronchioalveolar and large cell, 1 each. Twenty-four patients had stage IV at diagnosis, 12 had stage III and 1 had stage II. All had received at least one prior regimen (median 1, range 1 to 4): Carboplatin and Gemcitabine, 21 patients; Carboplatin, Irinotecan and Paclitaxel, 9; Gefitinib, 9; Carboplatin and Paclitaxel, 6; Erlotinib, 2; Gemcitabine and Cisplatin, Single agent paclitaxel, Carboplatin and Docetaxel, Cisplatin and Etoposide, 1 patient each. Twenty-nine individuals had an ECOG PS of 0 or 1. Patients received a median of 2 cycles (total, 95; range 1 to 12). Grade 3 and 4 adverse events were as follows: anemia, 3 patients; pneumonia, 2 patients; neutropenic fever, 1 patient; thrombocytopenia, 1 patient. Five (14%) patients had an objective response (1 CR, 4 PR) and 13 (35%) had stable disease. Median Time to Treatment Failure was 8 weeks. Median overall survival was 80 weeks. The median age for patients with mesothelioma was 46.5 years (range 29 to 73). Five men and one woman (4 ethnic Chinese, 1 Indian and 1 Arab) received a median of 4 cycles (total 30, range 1 to 15) of Pemetrexed in combination with cisplatin. Three patients had a PR, 2 had SD and one had progressed at the time of first evaluation. Grade 3 and 4 toxicity was as follows: leukocytopenia, neutropenia, and thrombocytopenia, 1 patient. Conclusions: Pemetrexed is safe and active in the treatment of Asian patients with NSCLC and mesothelioma. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Eli Lilly
Personality disorders in DSM-III and DSM-III-R: convergence, coverage, and internal consistency
Authors: L C Morey
Journal: American Journal of Psychiatry (1988)

Although many sections of DSM-III-R reflect few changes from DSM-III, the diagnostic criteria for the personality disorders involve more substantial revisions. This study examined the impact of DSM-III-R revisions in terms of convergence with DSM-III, the diagnostic coverage of patients with personality disorders, and the internal consistency of the personality disorder criteria sets. The results demonstrated a substantial divergence between DSM-III and DSM-III-R diagnoses, increased coverage accompanied by a large increase in overlap among personality disorders, and internal consistency estimates of DSM-III-R criterion sets comparable to those in DSM-III.
Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels
Authors: Valentin K. Gribkoff, John E. Starrett, Steven I. Dworetzky, Piyasena Hewawasam, Christopher G. Boissard, Deborah A. Cook, Stephen W. Frantz, Karen Heman, Jeffrey R. Hibbard, Kevin Huston, Graham Johnson, Bala S. Krishnan, Gene G. Kinney, Lynn A. Lombardo, Nicholas A. Meanwell, Perry B. Molinoff, Robert A. Myers, Sandra L. Moon, Astrid Ortiz, Lorraine Pajor, Rick L. Pieschl, Debra J. Post-Munson, Laura J. Signor, Nugehally Srinivas, Matthew T. Taber, George Thalody, Joanne T. Trojnacki, Harvey Wiener, Krishnaswamy Yeleswaram, Sarita W. Yeola
Journal: Nature Medicine (2001)
Randomized trial of systematic lymphadenectomy (LY) vs nodal sampling (SA) at second look surgery (SLS) in ovarian cancer patients: Final results
Authors: F. Landoni, A. Maggioni, T. Dell’anna, P. Benedetti Panici, N. Manci, V. Torri, R. Tironi, R. Garcia Parra, C. Falci, R. Fossati
Journal: Journal of Clinical Oncology (2006)

5068 Background: The role of systematic pelvic and para-aortic lymphadenectomy at SLS in ovarian cancer patients has not been addressed by randomized clinical trials (RCTs). We conducted a RCT to determine whether LY improves progression-free (PFS) and overall survival (OS) compared with SA. Methods: From January 1991 through December 1999, 303 eligible patients (i.e. patients with FIGO stage I-IV epithelial ovarian carcinoma at up front surgery and in complete remission after primary debulking surgery and first line chemotherapy) were randomly assigned to undergo LY (N = 156) or SA (N = 147) at the end of SLS. Survival was analyzed using a Cox multivariable regression analysis. All statistical tests were two-sided. Results: Median operating time was longer and the percentage of patients requiring blood transfusions was higher in the LY arm than the SA (240 vs 135 min., P &lt; .001, and 30% vs 10%, P &lt; .001, respectively). In the LY arm and SA arm the median number of removed nodes and the percentages of patients with nodal involvement was statistically different (44 vs 8, P &lt; .0001, and 24% vs 13%, P = 0.018, respectively). At a median follow-up of 59 months, 156 events (i.e., recurrences or deaths) were observed, and 98 patients had died. The 5-year progression-free and overall survival was 41% and 65% for LY, 49% and 61% for SA, respectively. The risk for first event (hazard ratio [HR] = 1.11, 95% CI = 0.81 to 1.53; P = .50) and death (HR = 0.79, 95% CI = 0.53 to 1.18; P = .24) after adjustment for residual tumor at first surgery was not significantly different between the two arms. Conclusions: Although LY at SLS seemed to improve overall survival, this survival gain (21% decrease in the hazard of death) was not statistically significant and therefore the routine use of LY at SLS for ovarian cancer is not supported by this RCT. No significant financial relationships to disclose.
A Single Course of 2-chloro-deoxyadenosine (2-cda) Does Not Eradicate Leukemic-cells in Hairy-cell Leukemia (hcl) Patients Achieving Complete Remission
Authors: B. Filleul, Augustin Ferrant, André Delannoy, A. Zeenebergh, André Bosly, Chantal Doyen, P. Mineur, P. Driesschaert, G. Sokal, P. Martiat, Jl. Michaux
Journal: Blood (1993)
Abstract 11766: 3d Strain in Evaluating of Left Ventricular Mechanical Function in Athletes
Authors: Laura Stefani, Alessio De Luca, loira Toncelli, Gianni Pedrizzetti, Giorgio Galanti
Journal: Circulation (2014)

Introduction:  Regular physical exercise induces morphological and functional heart’s modifications, the so called “athlete’s heart, whose characterization is based on morphology only.   Hypothesis:  The study aims to exploit the potential of 3D strain to improve the physiological understanding of LV functional changes in trained athletes.   Methods:  Three age-matched groups of young (age 20.3±5.4) individuals are prospectively enrolled: 13 normal healthy subjects (Controls), 15 professional athletes (Athletes), and 20 professional athletes with bicuspid aortic valve and low-to-mild aortic regurgitation (BAV Athletes). They underwent echocardiographic examination and both 2D and 3D strain analysis.   Results:  All echo parameters were within the normal range in the three groups. Global values of end-systolic longitudinal and circumferential strain, assesses by either 2D or 3D analysis, were not significantly different. The 3D strain analysis was extended in terms of principal and secondary strain (PS, SS). Global PS was not different, global SS was significantly higher in athletes (Controls: -6.6%±3.0, Athletes: -12.8%±2.8, BAV Athletes: -12.4%±6.3; p   Conclusions:  3D strain analysis allows a deeper physiological understanding of LV contraction. Secondary strain, only available in 3D, detected improvement of performances in Athletes with normal systolic function. This appear to be a result of the synergic activation of endocardial and epicardial fibers, with minor differences in presence of BAV where exercise may play a protective role.
Gender and diagnostic performance of the growth hormone response to clonidine for major depression : A large scale multicenter study
Authors: Michel Schittecatte, Gerard Charles, R. Machowski, P. Dumont, J. Garcia-Valentin, Jean Wilmotte, Patrick Papart, William Pitchot, Jacques Wauthy, Marc Ansseau, Isidor Pelc, Guy Hoffman
Journal: American Journal of Psychiatry (1994)
The Man a Woman Marries: Problems in Consideration.
Authors: Victor Cox Pedersen
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Behavioral characteristics of high- and low-IQ autistic children
Authors: B J Freeman, E R Ritvo, P C Schroth, I Tonick, D Guthrie, L Wake
Journal: American Journal of Psychiatry (1981)

The authors are developing the Behavior Observation Scale to objectively differentiate autistic, normal, and mentally retarded children aged 30--60 months. They describe operational definitions and procedures and report data on the frequency of selected behaviors among 114 children. Prior studies have revealed that to assess the clinical significance of behaviors in autistic children, both frequency of occurrence per subject and the number of children exhibiting the behaviors must be considered concurrently. This study confirms the hypothesis that it is critical to consider the IQ of the child when assessing the clinical significance of individual behaviors and groups of behaviors.
Clinical Method: A General Practice Approach.
Authors: Robin C. Fraser
Journal: Annals of Internal Medicine (1988)

Preface List of contributors Setting the scene The consultation The diagnostic process Patient management The doctor-patient relationship Doctor-patient communication Anticipatory care A systematic approach in the consultation to lifestyle modification: helping patients to stop smoking Ethics in practice Clinical problem-solving and patient management: some practical challenges Assessing and enhancing consultation performance Appendix: The detailed contribution of general practice to undergraduate medical education and to the attributes of the independent practitioner.
Monthly estimates of leisure-time physical inactivity - United States, 1994.
Authors: J. Cook, P. Owen, B. Bender, J. Senner, B. Davis, M. Leff, M. Adams, F. Breukelman, C. Mitchell, D. McTague, E. Pledger, J. Cooper, C. Johnson, B. Steiner, N. Costello, A. Wineski, M. Perry, K. Asher, R. Meriweather, D. Maines, A. Weinstein, D. Brooks, H. McGee, N. Salem, P. Arbuthnot, T. Murayi
Journal: MMWR Morbidity and Mortality Weekly Report (1997)
New Types of Old Americans at Harvard and at Eastern Women's Colleges.
Authors: Gordon Townsend Bowles
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die primäre Verrücktheit: Psychopathologische, klinische und genealogische Untersuchungen.
Authors: Kurt Kolle
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 814: Atorvastatin Attenuates Oxidative Stress And Improves Neuronal Nitric Oxide Synthase In The Brain Stem Of Heart Failure Mice
Authors: Joseph Francis, Li Yu, Anuradha Guggilam, Srinivas Sriramula, Irving H Zucker
Journal: Circulation (2007)

3-Hydroxyl-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been shown to reduce the incidence of myocardial infarction independent of their lipid-lowering effects. Nitric oxide (NO) in the central nervous system contributes to cardiovascular regulatory mechanisms. Imbalance between nitric oxide (NO) and superoxide anion (O 2 . − ) in the brain may contribute to enhanced sympathetic drive in heart failure (HF). This study was done to determine whether treatment with atorvastatin (ATS) ameliorates the imbalance between NO and O 2 . − production in the brain stem and contributes to improvement of left ventricular (LV) function. Methods and Results: Myocardial infarction (MI) was induced by ligation of the left coronary artery or sham surgery. Subsequently, mice were treated with ATS (10 μg/kg) (MI + ATS), or vehicle (MI + V). After 5 weeks, echocardiography revealed left ventricular dilatation in MI mice. Realtime RT-PCR indicated an increase in the mRNA expression of the LV hypertrophy markers, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Neuronal NOS (nNOS) and endothelial NOS (eNOS) mRNA expression were significantly reduced, while that of NAD(P)H oxidase subunit (gp91phox) expression was elevated in the brain stem of MI mice. Compared with sham-operated mice, ATS-treated mice showed reduced cardiac dilatation, decreased ANP and BNP in the LV. ATS also reduced gp91phox expression and increased nNOS mRNA expression in the brain stem, while no changes in eNOS and iNOS were observed. Conclusion: These findings suggest that ATS reduces oxidative stress and increases neuronal NOS in the brain stem, and improves left ventricular function in heart failure.
Die Croon-Vorlesungen über Aufbau und Abbau des Nervensystems. (Croonian Lectures on the Evolution and Dissolution of the Nervous System.)
Authors: J. Hughlings Jackson, Otto Sittig
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 11936: Development of Monthly to Quarterly Subcutaneous Administration of RNAi Therapeutics Targeting the Metabolic Diseases Genes PCSK9, ApoC3 and ANGPTL3
Authors: Anna Borodovsky, William Querbes, Jessica Sutherland, Renta Hutabarat, Stuart Milstein, Satya Kuchimanchi, Rajeev Kuchimanchi, Klaus Charisse, Kristina Yucius, Abigail Liebow, Andrew Sprague, Martin Maier, David Kallend, Amy Simon, Jay Horton, Kevin Fitzgerald
Journal: Circulation (2014)

Introduction: Cardiovascular disease remains the top cause of mortality in the United States. We have developed, and validated in human trials, a platform for reducing the synthesis of genes expressed in the liver. The platform utilizes a GalNAc sugar ligand attached to the 3’end of the sense strand of an RNAi molecule to enable delivery specifically to the liver. Here we present data from this platform on multiple targets of interest in cardiovascular disease, including PCSK9, ANGPLT3 and ApoC3. Hypothesis: RNAi therapeutics targeting liver genes of interest (such as PCSK9, ApoC3 and Angptl3) will allow for control of lipid levels and reduce the risk of cardiovascular disease. Methods: Chemically modified siRNAs were designed using bioinformatic algorithms and were screened for potency in vitro . pM active siRNA molecules were developed targeting PCSK9, ANGPLT3 and ApoC3. Results: ALN-PCSsc: In NHPs a single dose of ALN-PCSsc at ≥ 6 mg/kg reduced circulating PCSK9 levels up to 97% and LDL-C up to 67%. Moreover the nadir effect ( where LDL-C is clamped) lasted ~90 days suggesting that once monthly to quarterly dosing could be supported. Multidose studies in NHP at 2 mg/kg reduced circulating PCSK9 levels up to 94% with a subsequent lowering of LDL-C up to 67%. Safety studies in rat and NHP at doses up to 300 mg/kg (multi-dose) showed that ALN-PCSsc was safe demonstrating potential for a very wide therapeutic index. ALN-PCSsc was selected as a development candidate and is being advanced towards an IND for the treatment of hypercholesterolemia. ALN-ANGsc: Was tested in two models of hyperlipidemia, the OB/OB mouse and the hCETP-ApoB mouse. In the Ob/Ob model, treatment with ALN-ANGsc at 3mg/kg resulted in a significant lowering ANGPLT3 protein (&gt;95%), cholesterol (&gt;60%) and triglycerides (&gt;85%). ALN-ApoC3: Was tested in the db/db mouse model of hyperlipidemia. A robust lowering of plasma ApoC3 (&gt;90%) lead to a &gt;50% lowering of triglycerides. Screening for both programs is underway for a development candidates. Conclusions: We have developed a modular, robust and reliable platform for the delivery of RNAi therapeutics to the liver with a large therapeutic index. This small volume, subcutaneous, platform has a remarkable duration of effect.
Should “policlinics” replace “polyclinics”?
Authors: Michel R Odent
Journal: BMJ (2008)

The spellcheckers of my English and French computers accept both polyclinic and policlinic. Etymology suggests that the focus of polyclinic is the multiple competences of the heath professionals while that of policlinic (Greek: polis, the town) is proximity. Might spelling influence the current discussions?1
Abstract 6090: Major Prognostic Impact of Persistent Microvascular Obstruction as Assessed by Contrast-Enhanced Cardiac Magnetic Resonance Imaging in the Setting of Reperfused Myocardial Infarction
Authors: Alexandre Cochet, Marianne Zeller, Alain Lalande, Luc Lorgis, Claude Touzery, Paul Walker, Jean-Eric Wolf, Francois Brunotte, Yves Cottin
Journal: Circulation (2008)

To investigate the prognostic significance of microvascular obstruction (MO) and persistent microvascular obstruction (PMO) as assessed by Cardiac Magnetic Resonance Imaging (CMR) in patients with myocardial infarction (MI). CMR was performed in 184 consecutive patients during the week following successfully reperfused first MI. First-pass images were performed to evaluate presence or absence of MO and Late Gadolinium-enhanced images to assess extent of myocardial damage: regions of hyperenhancement, reflecting myocardial infarct size (IS) were manually contoured and expressed as a percentage of myocardial volume; regions of hypoenhancement, surrounded by hyperenhancement, reflecting PMO, were visually interpreted as present or absent. One-year follow-up was performed to collect the occurrence of Major Adverse Cardiac Event (MACE), as defined by cardiac death, non fatal recurrent MI, unstable angina or heart failure. MO was present in 127(69%) patients. PMO was present in 87 (46%) patients. Forty-four patients had MACE during the year following MI (including 5 cardiac death and 18 non fatal recurrent MI). By univariate logistic regression analysis, GRACE risk score>median (odds ratio [OR] 3.6; 95% confidence interval [CI] 1.8 –7.4; p 10% (OR 2.7; 95%CI 1.1– 6.9; p=0.04) LVEF median (OR 2.8; 95%CI 1.3– 6; p=0.01) presence of MO (OR 2.5; CI 1.0 – 6.2; p=0.04) and presence of PMO (OR 8.7; 95%CI 3.6 –21.1; p
The differentiation of vomiting/weight loss as a conversion disorder from anorexia nervosa
Authors: P E Garfinkel, A S Kaplan, D M Garner, P L Darby
Journal: American Journal of Psychiatry (1983)

The authors studied patients with weight loss and vomiting, distinguishing by means of objective criteria those who had what they feel is a conversion disorder from those with anorexia nervosa. The group of patients with conversion disorder were quite different from those with anorexia nervosa and could be considered as suffering from less pervasive psychological deficits. Medical and psychotherapeutic intervention must take into account the differences between these two groups for treatment to achieve maximal benefit.