tbuckley/cabot-search huggingface dataset:
A comparative analysis of perioperative complications and biochemical recurrence between standard and extended pelvic lymph node dissection in prostate cancer patients undergoing radical prostatectomy: a systematic review and meta-analysis
Authors: Guixin Ding, Gonglin Tang, Tianqi Wang, Qingsong Zou, Yuanshan Cui, Jitao Wu
Journal: International Journal of Surgery (2023)

Introduction: Pelvic lymph node dissection (PLND) is commonly performed during radical prostatectomy (RP) for prostate cancer staging. This study aimed to comprehensively analyze existing evidence compare perioperative complications associated with standard (sPLND) versus extended PLND templates (ePLND) in RP patients. Methods: A meta-analysis of prospective studies on PLND complications was conducted. Systematic searches were performed on Web of Science, Pubmed, Embase, and the Cochrane Library until May 2023. Risk ratios (RRs) were estimated using random-effects models in the meta-analysis. The statistical analysis of the data was carried out using Review Manager software. Results: Nine studies, including three randomized clinical trial and six prospective studies, with a total of 4962 patients were analyzed. The meta-analysis revealed that patients undergoing ePLND had a higher risk of partial perioperative complications, such as lymphedema ( I 2 =28%; RR 0.05; 95% CI: 0.01–0.27; P &lt;0.001) and urinary retention ( I 2 =0%; RR 0.30; 95% CI: 0.09–0.94; P =0.04) compared to those undergoing sPLND. However, there were no significant difference was observed in pelvic hematoma ( I 2 =0%; RR 1.65; 95% CI: 0.44–6.17; P =0.46), thromboembolic ( I 2 =57%; RR 0.91; 95% CI: 0.35–2.38; P =0.85), ureteral injury ( I 2 =33%; RR 0.28; 95% CI: 0.05–1.52; P =0.14), intraoperative bowel injury ( I 2 =0%; RR 0.87; 95% CI: 0.14–5.27; P =0.88), and lymphocele ( I 2 =0%; RR 1.58; 95% CI: 0.54–4.60; P =0.40) between sPLND and ePLND. Additionally, no significant difference was observed in overall perioperative complications ( I 2 =85%; RR 0.68; 95% CI: 0.40–1.16; P =0.16). Furthermore, ePLND did not significantly reduce biochemical recurrence ( I 2 =68%; RR 0.59; 95% CI: 0.28–1.24; P =0.16) of prostate cancer. Conclusion: This analysis found no significant differences in overall perioperative complications or biochemical recurrence between sPLND and ePLND, but ePLND may offer enhanced diagnostic advantages by increasing the detection rate of lymph node metastasis.
Red cell exchange for rapid leukoreduction in adults with hyperleukocytosis and leukostasis
Authors: Ethan A. Mack, Meaghan C. Dougher, Ashley M. Ginda, Caitlin Cahill, Melissa Murter, Kevin Schell, Yvette C. Tanhehco, Vijay G. Bhoj, Andrew D. Fesnak, Don L. Siegel, Taku Kambayashi, Nicole A. Aqui, Una O’Doherty
Journal: Blood (2023)
NIS2+TM as a screening tool to optimize patient selection in metabolic dysfunction-associated steatohepatitis clinical trials
Authors: Vlad Ratziu, Stephen A. Harrison, Yacine Hajji, Jeremy Magnanensi, Stephanie Petit, Zouher Majd, Elodie Delecroix, Christian Rosenquist, Dean Hum, Bart Staels, Quentin M. Anstee, Arun J. Sanyal
Journal: Journal of Hepatology (2023)

Strategies to reduce liver biopsy (LB) screen failures through better patient selection are needed for clinical trials. Standard fibrosis biomarkers were not derived to detect "at-risk" metabolic dysfunction-associated steatohepatitis (MASH; MASH with metabolic dysfunction-associated steatotic liver disease score ≥4 and fibrosis stage ≥2). We compared the performance of screening pathways that incorporate NIS2+™, an optimized version of the blood-based NIS4® technology designed to identify at-risk MASH, with those incorporating fibrosis (FIB)-4 within the RESOLVE-IT clinical trial (NCT02704403), aiming for optimized selection of patients for LB.
The efficacy and safety of hydrotherapy in patients with knee osteoarthritis: a meta-analysis of randomized controlled trials
Authors: Changjiang Lei, Haiting Chen, Su Zheng, Qingyun Pan, Jing Xu, Yuan Li, Yang Liu
Journal: International Journal of Surgery (2023)

Currently, there is poor evidence of the effect of hydrotherapy on patients with knee osteoarthritis (OA). The authors performed a meta-analysis from randomized controlled trials to determine the efficacy and safety of a hydrotherapy program on measures of pain and knee function in individuals living with knee OA.
Scrutinizing VTE risk factors in complex renal tumor patients: a comprehensive look at the VTE-RT-IVCTT study
Authors: Ru Chen, Zubing Mei, Jianhui Chen
Journal: International Journal of Surgery (2023)

aDepartment of Urology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou City, Fujian Province, 350000, China bDepartment of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, China cAnorectal Disease Institute of Shuguang Hospital, 201203, Shanghai, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Urology, Fujian Medical University Union Hospital, 29 Xinquan Road, Gulou District, Fuzhou City, Fujian Province, 350000, China. E-mail address: [email protected] (J. Chen). *Corresponding author. Address: Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine; Anorectal Disease Institute of Shuguang Hospital, 528 Zhangheng Road, Shanghai 201203, Shanghai, China. E-mail address: [email protected], [email protected] (Z. Mei). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Controversy Surrounding Bladder-Sparing Radical Dose Radiotherapy as an Alternative to Radical Cystectomy for Clinically Node-Positive Nonmetastatic Bladder Cancer
Authors: Wei He, Shuxiong Zeng, Chuanliang Xu
Journal: Journal of Clinical Oncology (2023)

Previous discussions of bladder-sparing strategies have revolved around a highly selected cohort of patients with node-negative locally muscle-invasive bladder cancer (MIBC).Swinton et al 1 conducted a multicenter, retrospective study on the basis of real-world data to evaluate whether bladder-sparing trimodal therapy (TMT) could be an effective alternative to radical cystectomy (RC) for patients with nonmetastatic nodepositive bladder cancer (cN1M0 BCa).The main findings showed that there was no significant difference in median overall survival (OS, 2.53 years v 2.09 years) and median progression-free survival (PFS, 1.93 years v 1.22 years) between radical dose radiotherapy (RadRT) and RC.Multivariate analysis revealed that the choice of radical treatment modality was not associated with OS (hazard ratio [HR], 0.94; 95% CI, 0.63 to 1.41; P 5 .76)or PFS (HR, 0.74; 95% CI, 0.50 to 1.08; P 5 .12).The authors should be applauded for their efforts to expand the knowledge of treatment options for cN1M0 BCa.However, some limitations should be considered before translating this study's results into clinical settings.
Carbon dioxide gas-induced pneumothorax versus one-lung ventilation in minimally invasive esophagectomy: a multicenter propensity score matching cohort study
Authors: Junying Chen, Jiao Heng, Bin Zheng, Taidui Zeng, Hao Wang, Peizong Wang, Yaobin Lin, Wuyou Gao, Chun Chen, Lijie Tan, Jianhua Fu
Journal: International Journal of Surgery (2023)

Background: Carbon dioxide gas-induced pneumoperitoneum might be the reason for the shorter postoperative survival of patients with malignant tumors. Whether CO 2 gas-induced pneumothorax has unfavorable impacts on the surgical and oncological outcomes of minimally invasive esophagectomy remains unclear. Methods: Between 2010 and 2016, a total of 998 patients with squamous cell carcinoma of the esophagus who received video-assisted surgery were registered from three large-volume medical centers. The overall survival (OS) and disease-free survival (DFS) were compared after using propensity score-matched and inverse probability-weighted methods. In addition, the tumor-relapse state was evaluated, and the relapse pattern was compared. Results: A total of 422 and 576 minimally invasive esophagectomies with intraoperative one-lung ventilation and CO 2 -induced pneumothorax were enrolled, respectively. The 5-year OS and DFS were similar between the CO 2 -induced pneumothorax (64.2% and 64.7%) and one-lung ventilation (65.3% and 62.4%) groups following propensity matching. The inverse probability weighting revealed similarly equal survival results in the two groups. The 5-year relapse rates were 35.1% and 30.6% in the one-lung ventilation and CO 2 -induced pneumothorax groups, respectively. Moreover, the relapse patterns were not significantly different between the two groups. Conclusion: The results of this study suggested that the use of intraoperative one-lung ventilation and CO 2 -induced pneumothorax have similar oncological outcomes; therefore, the two methods are both viable options in esophagectomy.
Changing patterns and surgical outcomes of small bowel obstruction in the era of minimally invasive surgery for colorectal cancer
Authors: Jin-Tung Liang, Yu-Tso Liao, Tzu-Chun Chen, John Huang, Ji-Shiang Hung
Journal: International Journal of Surgery (2023)

This study aimed to investigate whether the incidence, patterns, and surgical outcomes of small bowel obstruction (SBO) have changed in the era of minimally invasive surgery (MIS) for primary colorectal cancer (CRC).
Comment on ‘Efficacy of electroacupuncture in improving postoperative ileus in patients receiving colorectal surgery: A systematic review and meta-analysis’
Authors: Xian-Wen Liang, Liang Chen, Jin-Cai Wu
Journal: International Journal of Surgery (2023)

Department of Hepatobiliary and Pancreatic Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou 570311, Hainan Province, China # Co-first authorships: Liang Xian-Wen, and Chen Liang. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Hepatobiliary and Pancreatic Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou 570311, Hainan Province, China. Tel:+8618889765723. E-mail address: [email protected] (Wu. Jin-Cai). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A commentary on ‘Survival benefit and impact of adjuvant chemotherapy following systemic neoadjuvant chemotherapy in patients with resected pancreas ductal adenocarcinoma: a retrospective cohort study’
Authors: Furui Zhong, Chuanbo Xieb, Xuefeng Peng, Jinlong Luo, Hua Yang
Journal: International Journal of Surgery (2023)

aDepartment of General Surgery of Huidong, Zigong Fourth People's Hospital, Zigong, 643000, Sichuan Province, China bDepartment of Ultrasound, Zigong Hospital of Woman and Children Healthcare, Zigong, 643000, Sichuan Province, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of General Surgery of Huidong, Zigong Fourth People's Hospital, No. 282, Dangui Street, Ziliujing District, Zigong, 643000, Sichuan Province, China. Tel: +86 15884169385; E-mail address: [email protected] (H. Yang). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Neoadjuvant camrelizumab combined with paclitaxel and nedaplatin for locally advanced esophageal squamous cell carcinoma: a single-arm phase 2 study (cohort study)
Authors: Yingnan Yang, Jinfeng Zhang, Hongxue Meng, Xiaodong Ling, Xiaoyuan Wang, Yanzhong Xin, Hao Jiang, Luquan Zhang, Chengyuan Fang, Hao Liang, Jianqun Ma, Jinhong Zhu
Journal: International Journal of Surgery (2023)

Background: Neoadjuvant administration of immune checkpoint inhibitors (ICIs) combined with chemotherapy demonstrated promising efficacy and manageable safety in locally advanced esophageal squamous cell carcinoma (ESCC). This prospective, single-arm, phase 2 study evaluated the efficacy and safety of neoadjuvant therapy with camrelizumab plus paclitaxel and nedaplatin for 2–4 cycles in ESCC. Methods: Patients with locally advanced stage IIa–IIIb ESCC were enrolled in the study and received camrelizumab (200 mg), paclitaxel (155 mg/m 2 ), and nedaplatin (80 mg/m 2 ) intravenously on day one every 3 weeks. Patients underwent surgery after 2–4 cycles of treatment. The primary endpoint was the pathological complete response (pCR) rate. Secondary endpoints included the major pathological response (MPR) rate, R0 resection rate, tumor regression, objective response rate (ORR), and disease-free survival (DFS). Programmed cell death 1 ligand 1 (PD-L1) expression in tumor tissues was measured and quantified using immunohistochemistry staining and combined positive score (CPS), respectively. Results: In total, 75 patients were enrolled and received neoadjuvant treatment. Of them, 45 (60%) received two cycles, 18 (24%) received three cycles, and 10 patients (13.3%) received four cycles of neoadjuvant therapy. Ultimately, 62 patients (82.7%) underwent surgery. The patients achieved a pCR of 27.4% (95% CI: 16.9–40.2), an MPR of 45.2% (95% CI: 33.1–59.2), and an ORR of 48.4% (95% CI: 35.5–61.4); all patients had an R0 resection. T and N downstaging occurred in 39 (62.9%) and 19 (30.6%) patients Moreover, patients with CPS ≥10 tended to have enhanced ORR, pCR, and MPR compared to those with CPS &lt;10. Treatment-related adverse events (TRAEs) of grade 1–2 occurred in 59 (78.7%) patients, grade 3 TRAEs in four (5.3%), and one patient (1.3%) experienced a grade 4 TRAE. Conclusions: Neoadjuvant camrelizumab combined with chemotherapy showed promising efficacy in locally advanced ESCC, with a manageable safety profile, when administered flexibly in two to four cycles.
A practical tool for managing change: cross-sectional psychometric assessment of the safe surgery organizational readiness tool
Authors: Tuna C. Hayirli, John G. Meara, Egide Abahuje, Barnabas Alayande, Sylvio Augustin, David Barash, Adeline A. Boatin, Albino Kalolo, James Kengia, Paul Kingpriest, Innocent Kissima, Edwin R. Lugazia, Christophe Mpirimbanyi, Joseph Ngonzi, Abdoulie Njai, Victoria L. Smith, Ntuli Kapologwe, Shehnaz Alidina
Journal: International Journal of Surgery (2023)

Background: Strengthening health systems through planned safety and quality improvement initiatives is an imperative to achieve more equitable, resilient, and effective care. And yet, years of organizational behavior research demonstrate that change initiatives often fall short because managers fail to account for organizational readiness for change. This finding remains true especially among surgical safety and quality improvement initiatives in low- and middle-income countries. In this study, our aim was to psychometrically assess the construct validity and internal consistency of the Safe Surgery Organizational Readiness Tool (SSORT), a short survey tool designed to provide change leaders with insight into facility infrastructure that supports learning and readiness to undertake change. Materials and Methods: To demonstrate generalizability and achieve a large sample size (n=1,706) to conduct exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), a collaboration between seven surgical and anesthesia safety and quality improvement initiatives was formed. Collected survey data from health care workers were divided into pilot, exploration, and confirmation samples. The pilot sample was used to assess feasibility. The exploration sample was used to conduct EFA, while the confirmation sample was used to conduct CFA. Factor internal consistency was assessed using Cronbach’s alpha coefficient. Results: Results of the EFA retained 9 of the 16 proposed factors associated with readiness to change. CFA results of the identified 9 factor model, measured by 28 survey items, demonstrated excellent fit to data. These factors (appropriateness, resistance to change, team efficacy, team learning orientation, team valence, communication about change, learning environment, vision for sustainability, facility capacity) were also found to be internally consistent. Conclusion: Our findings suggest that communication, team learning, and supportive environment are components of change readiness that can be reliably measured prior to implementation of projects that promote surgical safety and quality improvement in low- and middle-income countries. Future research can link performance on identified factors to outcomes that matter most to patients.
A commentary on ‘Preoperative renal insufficiency predicts postoperative adverse outcomes in a mixed surgical population: a retrospective matched cohort study using the NSQIP database’
Authors: Wei Guo, Shu Li, Yuyu Zhao
Journal: International Journal of Surgery (2023)

Department of Nephrology, The Fourth People's Hospital Of Shenyang, Shenyang, Liaoning 110020, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Nephrology, The Fourth People's Hospital Of Shenyang, Shenyang, Liaoning 110020, China. E-mail address: [email protected] (W. Guo). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Inhibition of CAF-1 histone chaperone complex triggers cytosolic DNA and dsRNA sensing pathways and induces intrinsic immunity of hepatocellular carcinoma
Authors: For-Fan Chan, Vincent Wai-Hin Yuen, Jialing Shen, Don Wai-Ching Chin, Cheuk-Ting Law, Bowie Po-Yee Wong, Cerise Yuen-Ki Chan, Jacinth Wing-Sum Cheu, Irene Oi-Lin Ng, Carmen Chak-Lui Wong, Chun-Ming Wong
Journal: Hepatology (2023)

Chromatin assembly factor 1 (CAF-1) is a replication-dependent epigenetic regulator that controls cell cycle progression and chromatin dynamics. In this study, we aim to investigate the immunomodulatory role and therapeutic potential of the CAF-1 complex in HCC.
Reply to W. He et al
Authors: Martin Swinton, Peter Hoskin, Ananya Choudhury
Journal: Journal of Clinical Oncology (2023)

We agree with He et al 1 that there are limitations inherent to retrospective data and that results of our study 2 require careful interpretation and consideration of bias or potential confounders.Despite valiant attempts, a prospective randomized control trial comparing surgery to bladder preservation in bladder cancer (BC) has never been successful, 3 making retrospective comparisons the best available evidence in this setting.Our data represent the largest comparison of patients with node-positive BC and suggest that overall survival (OS) and progression-free survival (PFS) do not differ with choice of locally directed treatment. 2This finding in node-positive BC is consistent with retrospective analyses in node-negative BC comparing radical cystectomy (RC) and bladder preservation in matched cohorts.
Leveraging artificial intelligence for perioperative cancer risk assessment of oral potentially malignant disorders
Authors: John Adeoye, Yu-Xiong Su
Journal: International Journal of Surgery (2023)

Oral potentially malignant disorders (OPMDs) are mucosal conditions with an inherent disposition to develop oral squamous cell carcinoma. Surgical management is the most preferred strategy to prevent malignant transformation in OPMDs, and surgical approaches to treatment include conventional scalpel excision, laser surgery, cryotherapy, and photodynamic therapy. However, in reality, since all patients with OPMDs will not develop oral squamous cell carcinoma in their lifetime, there is a need to stratify patients according to their risk of malignant transformation to streamline surgical intervention for patients with the highest risks. Artificial intelligence (AI) has the potential to integrate disparate factors influencing malignant transformation for robust, precise, and personalized cancer risk stratification of OPMD patients than current methods to determine the need for surgical resection, excision, or re-excision. Therefore, this article overviews existing AI models and tools, presents a clinical implementation pathway, and discusses necessary refinements to aid the clinical application of AI-based platforms for cancer risk stratification of OPMDs in surgical practice.
UBXN9 inhibits the RNA exosome function to promote T cell control of liver tumorigenesis
Authors: Li Zhang, Kun Jiao, Yun Liu, Guiqin Xu, Zhaojuan Yang, Lvzhu Xiang, Zehong Chen, Chen Xu, You Zuo, Zhibai Wu, Ningqian Zheng, Xiaoren Zhang, Qiang Xia, Yongzhong Liu
Journal: Hepatology (2023)

Background and Aims: Liver tumorigenesis encompasses oncogenic activation and self-adaptation of various biological processes in premalignant hepatocytes to circumvent the pressure of cellular stress and host immune control. Ubiquitin regulatory X domain-containing proteins (UBXNs) participate in the regulation of certain signaling pathways. However, whether UBXN proteins function in the development of liver cancer remains unclear. Approach and Results: Here, we demonstrated that UBXN9 (Alveolar Soft Part Sarcoma Chromosomal Region Candidate Gene 1 Protein/Alveolar Soft Part Sarcoma Locus) expression was decreased in autochthonous oncogene-induced mouse liver tumors and ~47.7% of human HCCs, and associated with poor prognosis in patients with HCC. UBXN9 attenuated liver tumorigenesis induced by different oncogenic factors and tumor growth of transplanted liver tumor cells in immuno-competent mice. Mechanistically, UBXN9 significantly inhibited the function of the RNA exosome, resulting in increased expression of RLR-stimulatory RNAs and activation of the retinoic acid-inducible gene-I-IFN-Ι signaling in tumor cells, and hence potentiated T cell recruitment and immune control of tumor growth. Abrogation of the CD8 + T cell response or inhibition of tumor cell retinoic acid-inducible gene-I signaling efficiently counteracted the UBXN9-mediated suppression of liver tumor growth. Conclusions: Our results reveal a modality in which UBXN9 promotes the stimulatory RNA-induced retinoic acid-inducible gene-I-interferon signaling that induces anti-tumor T cell response in liver tumorigenesis. Targeted manipulation of the UBXN9-RNA exosome circuit may have the potential to reinstate the immune control of liver tumor growth.