tbuckley/cabot-search huggingface dataset:
Abstract 4840: Tako-Tsubo Cardiomyopathy without Apical Ballooning - Results of the German Tako-Tsubo Registry
Authors: Anastasios Athanasiadis, Birke Schneider, Johannes Schwab, Uta Gottwald, Ellen Hoffmann, Juergen Hauber, Karl Giso Mackes, Chrisoph Stellbrink, Wolfgang von Scheidt, Udo Sechtem
Journal: Circulation (2008)

Background : The German tako-tsubo cardiomyopathy (TTC) registry has been initiated to further evaluate this syndrome in a western population. We aimed to assess different patterns of left ventricular involvement in TTC. Methods : Inclusion criteria were: 1) acute chest symptoms, 2) reversible ECG changes (ST-segment elevation±T-wave inversion), 3) reversible left ventricular dysfunction with a wall motion abnormality not corresponding to a single coronary artery territory, 4) no significant coronary artery stenoses. Results : A total of 258 patients (pts) from 33 centers were included with a mean age of 68±12 years. Left ventriculography revealed the typical pattern of apical ballooning in 170 pts (66%) and an atypical mid-ventricular ballooning with normal wall motion of the apical and basal segments in 88 pts (34%). Mean age (68±11 vs 67±13 years) and gender distribution (150 women/20 men vs 80 women/8 men) were similar in both groups. Triggering events were present in 78% of the pts with apical ballooning (35% emotional, 34 physical and 9% combination) and in 75% of the pts with mid-ventricular ballooning (39% emotional, 25% physical and 11% combination). As assessed by left ventriculography, ejection fraction was significantly lower in pts with mid-ventricular ballooning (50±15% vs 45±13%, p=0.006). There was no difference in right ventricular involvement. Creatine kinase and troponin I were comparable in both groups. The ECG on admission showed ST-segment elevation in 87% of pts with apical ballooning and in 78% of pts with mid-ventricular ballooning. T-wave inversion was seen in 70% of the pts irrespective of the TTC variant. A Q-wave was significantly less present in pts with mid-ventricular ballooning (30% vs 16%, p=0.04). The QTc interval during the first 3 days was not different among both groups. Conclusion : A variant form with mid-ventricular ballooning was observed in one third of the pts with TTC. Left ventricular ejection fraction was significantly lower in these pts, although they revealed significantly less Q-waves on the admission ECG. All other parameters were similar and confirm the concept that apical and mid-ventricular ballooning represent two different manifestations of the same syndrome.
Abstract 4838: Diffuse, Marked, Reversible Impairment in Coronary Microcirculation in Stress Cardiomyopathy: A Vasodilator Stress Echo Study
Authors: Fausto Rigo, Rosa Sicari, Rodolfo Citro, Giovanni Ossena, Paolo Buja, Eugenio Picano
Journal: Circulation (2008)

Stress cardiomyopathy, also referred to as Takotsubo cardiomyopathy (TC) has been linked to excessive sympathetic stimulation, which can be toxic for myocytes and coronary microcirculation. Aim: To assess coronary flow reserve (CFR) in TC. Methods: 30 consecutive patients (5 males; 68±12 years) meeting diagnostic criteria for TC were evaluated with transthoracic dipyridamole (0.84 mg/kg over 6′) stress echo and Pulsed Doppler CFR assessment on mid-distal left anterior descending (LAD) and posterior descending of right coronary artery (PD). Wall Motion Score Index (WMSI) was evaluated at baseline and during stress. All patients were followed-up clinically and - on day 1, day 7 (±2 days) and at 6 months - by repeat stress echo. Twenty-one age and gender matched controls were also studied. Results: CFR was obtained in all patients on LAD and in 25 on PD. All pts showed a transient apical ballooning in the acute phase (day 1 of admission), with progression recovery of function at follow-up (WMSI, day 1=1.7±.2; day 7=1.4±.14; 6-months=1.0±0.1; p&lt;0.001 vs day 1 and vs. day 7). When compared to controls, CFR was reduced on day 1 (upon admission) and it showed early recovery in the subacute (pre-discharge) assessment on day 7. CFR values remained stable at 6-months follow-up (see figure ). Conclusion: TC is characterized by a profound, diffuse, coronary microcirculatory disturbance in the acute phase, with early reversal to near-normal values within a few days, paralleling the functional recovery in regional wall motion. The reversible coronary microcirculatory abnormality can be observed also in the territory of right coronary artery.
The validity of DSM-III axis IV (severity of psychosocial stressors)
Authors: Mark Zimmerman, Bruce Pfohl, Dalene Stangl, William Coryell
Journal: American Journal of Psychiatry (1985)

One hundred thirty depressed inpatients were rated on DSM-III axis IV on the basis of information collected from a comprehensive life events interview. Axis IV scores were more highly correlated with undesirable than desirable events, with exits than entrances, and with time-limited than chronic events. Higher axis IV scores were associated with a lower rate of abnormal dexamethasone suppression test results, a higher morbid risk for alcoholism, a greater frequency of personality disorders, and a greater likelihood of attempted suicide during the index episode.
Patient Derived Xenograft (PDX) Models Faithfully Recapitulate The Genetic Composition Of Primary AML
Authors: Andrei V. Krivtsov, Wang Xujun, Noushin Rahnamay Farnoud, Michael Hadler, Kristina M. Knapp, Eytan M Stein, Martin S. Tallman, Amy L Donahue, Doron Lipson, Michelle K. Nahas, Philip J. Stephens, Eric M Sanford, Kai Wang, Garrett M Frampton, Tim Brennan, Geoff A. Otto, Roman Yelensky, Vincent A. Miller, Ross L. Levine, Scott A. Armstrong
Journal: Blood (2013)
The Impact Of European Leukemia Net (ELN) Genetic Classification On The Outcome Of Allogeneic Stem Cell Transplantation (ALLOHCT) For Acute Myeloid Leukemia (AML) In First Complete Remission
Authors: Jorge Sierra, Ana Garrido, Mar Tormo, Ramon Guardia, Josep F Nomdedeu, Jordi Esteve, Josep-Maria Ribera, Rafael F. Duarte, M. Paz Queipo De Llano, Olga Salamero, Carmen Pedro, Joan Bargay, Juan Besalduch, Andreu Llorente, Montserrat Hoyos, Montserrat Arnan, Marta Pratcorona, Susana Vives, Marisa Calabuig, David Gallardo, Salut Brunet
Journal: Blood (2013)
Abstract P356: In Vitro Effect of Blackcurrant Anthocyanins on Flow-Dependent Dilatation of Human Intracerebral Arteries and Alzheimer Nanoplaque Formation
Authors: Guenter Siegel, Eugeny Ermilov, Stephanie Hammersen, Gwenda Elmen
Journal: Circulation (2012)

Background: Vascular wall amyloidosis, one of the important cell and tissue changes in dementiae of the Alzheimer type, is characterized by massive deposition of β-amyloid in the walls of leptomeningeal and cortical arteries and arterioles, as well as in vessels in the brainstem and cerebellum. This deposition depends critically on both lipoprotein isoform and cholesterol, which has prompted research on the link between coronary disease and Alzheimer's disease. High cholesterol diets were found to induce accumulation of β-amyloid in the brain. Anthocyanins from blackcurrant extract (BCE) may have beneficial effects on Alzheimer dementiae via other target points than cholesterol lowering. Materials and Methods: Flow-dependent isometric tension was measured in segments of isolated human intracerebral arteries from consciousness areas, coming from brain surgery. The blood vessel segments were stretched by 1.5 g pretension. The flow of the blood substitute solution (Krebs) was varied in the steps 3, 5, 20, 40, and 100 mL/min. Krebs solution without and with addition of 0.01% BCE (BC ACL-1.5, BerryPharma AG, Leichlingen, Germany) was used as superfusate. Nanotechnologic biosensor ellipsometry, photometric methods, ELISAs and EIAs were applied. VLDLapoE4/E4 (10 mg/dL) from genotypized patients and human β-amyloid peptide (1-42) (Aβ) were used in the ellipsometric measurements. Results: In the controls (n = 14), the smooth muscle cells of the brain arteries relaxed from 1.416 ± 0.009 g to 1.011 ± 0.033 g (p &lt; 0.001) corresponding to 28.6% of their initial tone. Under blackcurrant liquid extract (n = 5), the decrease in wall tension was much more distinct. Vascular tone decreased from 1.454 ± 0.010 g (flow 3 mL/min) to 0.867 ± 0.052 g (flow 100 mL/min) (p &lt; 0.001; against the control p &lt; 0.0354). This is equivalent to a 40.4% reduction in tension, a 45.2% increase in flow-dependent relaxation, and an estimated 50.7% rise in blood perfusion under blackcurrant. BCE (0.001%) is strongly bound to membrane integral proteoheparan sulphate (HS-PG), the natural flow sensor and peripheral lipoprotein receptor, as measured by ellipsometric techniques. Addition of VLDLapoE4/E4, Aβ, and Ca 2+ ions (2.52 to 17.64 mmol/L) to HS-PG adsorbed to a silica surface led to quaternary Alzheimer plaque formation in control experiments. Preincubation of HS-PG with BCE reduced VLDL docking by 5.9%, ternary plaque formation with Aβ by 11.6%, and quaternary calcified Alzheimer nanoplaque formation by 17.3%. Conclusion: The flow experiments impressively show that BCE clearly improves endothelial function by an additional NO release. This vasodilatation together with the reduction of Alzheimer nanoplaque neoformation, detected here for the first time as a novel pleiotropic action of BCE, may have a beneficial effect on the cognitive functions in dementiae of the Alzheimer type, in the prevention of TIA and stroke.
Abstract 9586: Existence of Small Juvenile Cells in the Aging Bone Marrow Stromal Cells and Their Therapeutic Potential for Ischemic Heart Disease
Authors: Motoi Okada, Husnain K Haider, Koichi Igura, Seojin Kim, Shujia Jiang, Muhammad Ashraf
Journal: Circulation (2011)

Background: We have previously reported that aging of stem cells compromises their growth and proliferation potential and their regenerative capacity post transplantation in the infarcted heart. We have identified small juvenile population of stem cells in aging rat derived bone marrow (BM) which expressed cardiac lineage markers GATA-4 and MEF-2C. We proposed that these cells possessed great potential for repair of the ischemic heart. Methods and Results: Small cells were isolated from male young ( Yng Small; 8-12 weeks) and old ( Old Small; 24-28 months) Fischer-344 rats BM-stromal cells by filtration through 3 μ m pore sized sieve. The proliferation and colony formation capacity of Yng Small cells and Old Small cells were significantly higher than total population of the old cells ( Old Hetero). Flow cytometry showed both Old Small and Yng Small cells were positive for CD29, CD44, CD59 (Sca-1 homologue) and CD90 but negative for CD45 and CD117 (c-kit). Myocardial regenerative capacity of Old Small and Old Hetero cells was assessed in a rat model of acute myocardial infarction (n=10 /group) using DMEM injected animals as controls. Echocardiography at 4 weeks after cell transplantation showed preserved indices of global heart function including left ventricle (LV) diastolic volume ( Old Hetero: 58.2±3.6 vs Old Small: 40.1±5.4ml, p &lt;0.01), LV ejection fraction ( Old Hetero: 48.2±5.1 vs Old Small: 55.2±3.8%, p &lt;0.05) and fractional shortening ( Old Hetero: 19.8±3.5 vs Old Small: 23.5±2.1%, p &lt;0.05) in Old Small cell treated animals. Histological studies showed smaller infarction size in Old Small cell treated hearts ( Old Hetero: 53.5±3.1 vs Old Small: 41.0±2.9, p &lt;0.01). Border zone capillary density was higher in Old Small group ( Old Hetero: 29.0±9.5 vs Old Small: 39.5±10.2%, p &lt;0.05). We also confirmed that the QDot labeled Old Small cells differentiated into cardiac and endothelial cells as indentified by actinin and vWF-VIII specific immunostaining. Conclusions: Old Small cell transplantation enhanced angiogenesis in border zone of infarcted heart and improved LV function as compared to Old Hetero. These findings suggested that Old Small cells could be excellent source for autologous cell transplantation in elderly patients for better prognosis.
Abstract 8682: Microarray and Proteomic Analysis of Cardioprotection in the Mature and Aged Male and Female: Role of the Mitochondrion and Mitochondrial Pathways
Authors: Kendra M Black, Reanne Barnett, Manoj K Bhasin, Christian Daly, Simon J Dillon, Towia A Libermann, Akihiro Masuzawa, Sidney Levitsky, James D McCully
Journal: Circulation (2011)

Background: Recently we have shown that cardioprotection afforded by cardioplegia is modulated by RNA and protein dependent mechanisms and is significantly decreased with age and in particular is significantly decreased in the aged female, however, the pathways associated with these differences were unknown. Methods: Mature male and female (15 to 20 weeks; n=6 each) and aged male and female (&gt;32 months; n=6 each) New Zealand White rabbits were used for in situ blood perfused cardiopulmonary bypass (CPB). Control hearts received 30 min sham global ischemia (GI) and 120 min sham reperfusion. GI hearts received 30 min GI, achieved by crossclamping of the aorta. Cardioplegia hearts received cold blood cardioplegia prior to GI. Following 30 min GI the crossclamp was released and the hearts were reperfused for 120 min. RNA and proteins were isolated and microarray and proteomic analysis was performed on matched samples. Results: Microarray analysis showed that cardioplegia up-regulated genes for transcription and the mitochondrion in mature male and female hearts and cytoskeleton dependent intracellular transport and cell-substrate function in aged male and female hearts. Proteomic analysis identified 362 proteins of which 132 were common to all groups. Principal component analysis indicated differential protein expression in each treatment in the mature male and female and aged male, but in the aged female there was no difference in the proteins expressed during GI and cardioplegia. Cardioplegia up-regulated glycolytic and gluconeogenic pathways in the mature and aged male and oxidative phosphorylation, the electron transport chain, propanoate and pyruvate metabolism and the induction of apoptosis in the mature and aged female. The tricarboxylic acid cycle was uniquely up-regulated by cardioplegia in the aged female but not glycolysis or gluconeogenesis. Conclusions: These data demonstrate that the mitochondrion and mitochondrial pathways play a key role in age and gender specific cardioprotection. The identification of these specific pathways will allow for the development of age and gender specific cardioprotection which should significantly decrease morbidity and mortality in the aged female undergoing open heart surgery.
Clinical effects of clozapine in chronic schizophrenia: response to treatment and predictors of outcome
Authors: J A Lieberman, A Z Safferman, S Pollack, S Szymanski, C Johns, A Howard, M Kronig, P Bookstein, J M Kane
Journal: American Journal of Psychiatry (1994)

This study addressed the unique clinical properties attributed to the atypical antipsychotic clozapine, including its efficacy in patients with treatment-refractory psychosis and against negative symptoms, its lack of acute extrapyramidal side effects, and the longer time course of its therapeutic effects.The clinical responses of 84 schizophrenic inpatients (66 with treatment-refractory illness and 18 who were intolerant of antipsychotic treatment) were examined. After all previous antipsychotic medications had been withdrawn, the patients were treated with clozapine according to a standardized titration and dosage schedule. Patients who tolerated and responded to treatment were discharged and maintained on a regimen of clozapine for up to 52 weeks. Patients were evaluated for behavioral response and side effects after weeks 3, 6, 12, 26, 39, and 52 of treatment.Fifty percent of the patients with treatment-refractory illness and 76% of the treatment-intolerant patients responded to clozapine in up to 52 weeks. The optimal period for a trial of clozapine appeared to be 12-24 weeks. Clozapine exhibited therapeutic effects on negative symptoms, but these were not clearly independent of its effects on positive symptoms and extrapyramidal side effects. Several variables, including early age at onset of illness and female gender, were found to be predictors of poor response to treatment. Predictors of good response included the presence of extrapyramidal side effects during previous treatment with classic neuroleptics and a diagnosis of paranoid schizophrenia.These findings have important implications for the use of clozapine and our understanding of the pathophysiology of treatment-resistant schizophrenia.
The incidence of mammary gland carcinoma and cancer age in mice injected with estrogen and in noninjected mice of different strains.
Authors: Suntzeff, Moskop Kirtz M, Blumenthal Ht, Loeb L
Journal: Cancer Research (1941)

There exists in general a parallelism between the cancer incidence of the mammary gland in breeding control mice of various strains and the readiness with which the cancer rate can be increased in these strains in nonbreeding female mice or the occurrence of mammary gland carcinoma can be induced in male mice by injections of estrogen.  This parallelism is due to the fact that in all of these cases we have to deal with the same mechanism; i.e. the production of carcinoma through the action of endogenous or exogenous ovarian hormones acting on a substratum with a definite inherited degree of growth tendency in the mammary gland.  The proportion between cancer incidence in breeding and nonbreeding control mice varies greatly in different strains and these differences must be considered as due to an inherited strain characteristic a conclusion which confirms earlier observations made with different strains of mice.  In breeding control mice belonging to strains with the highest incidence of mammary gland carcinoma the cancer rate was approximately as high in the 1st as in the later age classes.  In strains with a weaker inherited tendency to the development of mammary gland carcinoma and in nonbreeding mice even of high tumor rate strains the cancer incidence increases in the direction from the 1st-3rd age class.  This indicates that the earlier in life cancer in general appears the greater the intensity with which the causative factor acts.  A similar relationship is observed in mice treated with exogenous estrogens--the stronger the dose injected and the greater the inherited tendency to cancer the earlier the mammary gland carcinoma appeared in the various strains.  No significant difference in the incidence of this carcinoma was observed in male and nonbreeding female mice injected with large amounts of estrogen and belonging to strains with a strong hereditary tendency to the development of this type of cancer.  (authors)
Abstract 5454: Oxidative Stress is Associated with Arterial Dysfunction and Enhanced Intima-Media Thickness in Children with Hypercholesterolemia. Potential Role of Nadph Oxidase
Authors: Lorenzo Loffredo, Francesco Martino, Roberto Carnevale, Valerio Sanguigni, Ludovica Perri, Eliana Martino, Elisa Catasca, Cristina Zanoni, Pasquale Pignatelli, Francesco Violi
Journal: Circulation (2008)

Endothelial dysfunction and intima-media thickness (IMT) are precocious manifestations of hypercholesterolemia but the mechanism is unclear. The aim of the study was to analyse the interplay among endothelial dysfunction, IMT and oxidative stress in hypercholesterolemic children (HC). We performed a cross-sectional study comparing flow mediated dilation (FMD), IMT, lipid profile, urinary isoprostanes as markers of oxidative stress, and platelet expression of gp91phox, the catalytic unit of NADPH oxidase, in a population of 50 HC (mean age 10.0±3.7 years) and 50 normocholesterolemic children (NC) (mean age 9.2±3.5 years). Four children with hereditary deficiency of gp91phox were also studied. HC had reduced FMD (6.2±2.4 vs. 9.2±2.5%; p&lt;0.001) and enhanced IMT (0.45±0.07 vs. 0.40±0.06 mm; p&lt;0.002), urinary isoprostanes (86.9±51.6 vs. 45.9±25.6 pg/mg of creatinine; p&lt;0.001) and gp91phox platelet expression (4.4±3.8 vs. 2.0±1.7 mean fluorescence; p&lt;0.001) compared to controls. At bivariate analysis, FMD was correlated with LDL cholesterol (r= −0.448; p&lt;0.001), IMT (r=−0.356; p=0.01), urinary isoprostanes (r=−0.388; p=0.005) and platelet gp91phox (r=−0.314; p=0.02). Stepwise multiple linear regression analysis showed that in HC, FMD and IMT were significantly associated with LDL cholesterol and urinary isoprostanes; also, gp91phox platelet expression was an independent predictor of urinary isoprostanes. Children with gp91phox hereditary deficiency showed down-regulation of platelet gp91phox and reduced urinary excretion of isoprostanes. The study suggests that gp91phox -mediated oxidative stress may have a pathogenic role in the anatomic and functional changes of the arterial wall occurring in children with premature atherosclerosis.
Models for the joint effect of genotype and environment on liability to psychiatric illness
Authors: Kenneth S. Kendler, Lindon J. Eaves
Journal: American Journal of Psychiatry (1986)

The authors present three major models for the joint effect of genes and environment on liability to psychiatric illness: additive effects of genotype and environment, genetic control of sensitivity to the environment, and genetic control of exposure to the environment. Each model is illustrated by several examples, including a quantitative one. The authors attempt to demonstrate that genes and the environment can interact in several interesting and potentially subtle ways, that these interactions can be expressed in simple models from which clear empirical predictions can be generated, and that elucidation of the etiology of psychiatric disorders will require the consideration of both genetic and environmental risk factors.
Targeting The BRAF-MEK-ERK Pathway In Hairy Cell Leukemia
Authors: Valentina Pettirossi, Alessia Santi, Guido Russo, Alessandra Pucciarini, Barbara Bigerna, Elisabetta Fortini, Elisa Imperi, Roberta Mannucci, Ildo Nicoletti, Maria Paola Martelli, Enrico Tiacci, Brunangelo Falini
Journal: Blood (2013)
Abstract 15740: Coping Styles and Blood Pressure in African Americans: The Jackson Heart Study
Authors: Sandra H Dunn, Daniel F Sarpong, Frances C Henderson, Joycelyn C Graff, Mona N Wicks, Yvette P Conley, Ann K Cashion
Journal: Circulation (2012)

Few investigators have examined the relationship between coping and blood pressure in African Americans despite the higher rate of psychological distress reported by and the lack of a clear rationa...
Evaluation of bipolar radiofrequency ablation for occluded self-expandable metal stents in the bile duct: in vivo and in vitro study
Authors: Won Yoon, Yong-Tae Kim, Ebubekir Daglilar, Mari Mino-Kenudson, William Brugge
Journal: Endoscopy (2015)

Endobiliary radiofrequency ablation (RFA) has been used to treat occluded self-expandable metal stents (SEMSs). The aim of this study was to determine the characteristics of bipolar RFA in occluded SEMSs using both in vivo and in vitro models.For the in vivo study, uncovered SEMSs were deployed in the bile ducts of three pigs; another pig was used as the control. RFA was performed at 10 W for 90 seconds. The bile duct was examined for histological changes. For the in vitro simulation of tissue ingrowth in SEMSs, RFA at 10 W for 30 seconds was performed on SEMS-occlusion polyacrylamide-gel phantoms.The ablation depth was markedly reduced in the stented porcine bile duct. RFA of uncovered SEMS-occlusion gel phantoms resulted in early termination of RFA when the coagulated area contacted the SEMS. This phenomenon was not observed in RFA of the covered SEMS-occlusion gel phantoms.The presence of SEMSs attenuated the effect of bipolar endobiliary RFA. Tumorous tissue outside the SEMS is unlikely to be affected.