tbuckley/cabot-search huggingface dataset:
Cost-effectiveness of therapist-assisted internet-delivered psychological therapies for PTSD differing in trauma focus in England: an economic evaluation based on the STOP-PTSD trial
Authors: Ed Penington, Jennifer Wild, Emma Warnock-Parkes, Nick Grey, Hannah Murray, Alice Kerr, Richard Stott, Alexander Rozental, Gerhard Andersson, David M Clark, Apostolos Tsiachristas, Anke Ehlers
Journal: The Lancet Psychiatry (2024)

BackgroundAlthough there are effective psychological treatments for post-traumatic stress disorder (PTSD), they remain inaccessible for many people. Digitally enabled therapy is a way to overcome this problem; however, there is little evidence on which forms of these therapies are most cost effective in PTSD. We aimed to assess the cost-effectiveness of the STOP-PTSD trial, which evaluated two therapist-assisted, internet-delivered cognitive behavioural therapies: cognitive therapy for PTSD (iCT-PTSD) and a programme focusing on stress management (iStress-PTSD).MethodsIn this health economic evaluation, we used data from the STOP-PTSD trial (n=217), a single-blind, randomised controlled trial, to compare iCT-PTSD and iStress-PTSD in terms of resource use and health outcomes. In the trial, participants (aged ≥18 years) who met DSM-5 criteria for PTSD were recruited from primary care therapy services in South East England. The interventions were delivered online with therapist support for the first 12 weeks, and three telephone calls over the next 3 months. Participants completed questionnaires on symptoms, wellbeing, quality of life, and resource use at baseline, 13 weeks, 26 weeks, and 39 weeks after randomisation. We used a cost-effectiveness analysis to assess cost per quality-adjusted life year (QALY) at 39 weeks post-randomisation, from the perspective of the English National Health Service (NHS) and personal social services and on the basis of intention-to-treat for complete cases. Treatment modules and the platform design were developed with extensive input from service users: service users also advised on the trial protocol and methods, including the health economic measures. This is a pre-planned analysis of the STOP-PTSD trial; the trial was registered prospectively on the ISRCTN Registry (ISRCTN16806208).FindingsNHS costs were similar across treatment groups, but clinical outcomes were superior for iCT-PTSD compared with iStress-PTSD. The incremental cost-effectiveness ratio for NHS costs and personal social services was estimated as £1921 per QALY. iCT-PTSD had an estimated 91·6% chance of being cost effective at the £20 000 per QALY threshold. From the societal perspective, iCT-PTSD was cost saving compared with iStress-PTSD.InterpretationiCT-PTSD is a cost-effective form of therapist-assisted, internet-delivered psychological therapy relative to iStress-PTSD, and it could be considered for clinical implementation.FundingWellcome Trust and National Institute of Health Research Oxford Health Biomedical Research Centre.
Riociguat in patients with sickle cell disease and hypertension or proteinuria (STERIO-SCD): a randomised, double-blind, placebo controlled, phase 1–2 trial
Authors: Mark T Gladwin, Victor R Gordeuk, Payal C Desai, Caterina Minniti, Enrico M Novelli, Claudia R Morris, Kenneth I Ataga, Laura De Castro, Susanna A Curtis, Fuad El Rassi, Hubert James Ford, Thomas Harrington, Elizabeth S Klings, Sophie Lanzkron, Darla Liles, Jane Little, Alecia Nero, Wally Smith, James G Taylor, Ayanna Baptiste, Ward Hagar, Julie Kanter, Amy Kinzie, Temeia Martin, Amina Rafique, Marilyn J Telen, Christina M Lalama, Gregory J Kato, Kaleab Z Abebe
Journal: The Lancet Haematology (2024)
Development of a diagnostic prediction model for giant cell arteritis by sequential application of Southend Giant Cell Arteritis Probability Score and ultrasonography: a prospective multicentre study
Authors: Alwin Sebastian, Kornelis S M van der Geest, Alessandro Tomelleri, Pierluigi Macchioni, Giulia Klinowski, Carlo Salvarani, Diana Prieto-Peña, Edoardo Conticini, Muhammad Khurshid, Lorenzo Dagna, Elisabeth Brouwer, Bhaskar Dasgupta
Journal: The Lancet Rheumatology (2024)
Bridging the gap between testing and clinics exploring alternative pre-clinical models in melanoma research
Authors: Juliana Viegas, Bruno Sarmento
Journal: Advanced Drug Delivery Reviews (2024)

Melanoma, the deadliest form of skin cancer, poses a significant clinical challenge for the development of effective treatments. Conventional in vivo animal studies have shown limited translational relevance to humans, raising strength to pre-clinical models for melanoma research. This review provides an in-depth analysis of alternative pre-clinical models including in vitro and ex vivo platforms such as reconstructed skin, spheroids, organoids, organotypic models, skin-on-a-chip, and bioprinting. Through a comprehensive analysis, the specific attributes, advantages, and limitations of each model are elucidated. It discusses the points related to the uniqueness advantages, from capturing complex interactions between melanoma cells and their microenvironment to enabling high-throughput drug screening and personalized medicine approaches. This review is structured covering firstly the roadmap to identify the co-occurrence of discovering new melanoma treatments and the development of its models, secondly it covers a comparative between the most used models followed by a section discussing each of them: the in vitro and ex vivo models. It intends to serve as an asset for researchers of melanoma field and clinicians involved in melanoma therapy, offering insights into the diverse preclinical models available for optimizing their integration into the translational pipeline.
Personal versus therapist perioperative music intervention: a randomized controlled trial
Authors: Fan Jiang, Tingting Wang, Liqiong Hu, Shangui Chen, Lijian Chen, Xuesheng Liu, Yao Lu, Erwei Gu, Luis Ulloa
Journal: International Journal of Surgery (2024)

Introduction: Music interventions can alleviate patient anxiety and improve post-surgical satisfaction. However, it remains uncertain whether music personal preferences affect efficacy. We tested whether personal music intervention with patient-selected songs played ad libitum is more effective than standard therapist-designed treatment with classical music. Methods: A prospective, parallel-group, single-blinded, randomized controlled trial with 229 participants (aged 18 to 60 y) previously scheduled for elective surgery. Data analyses followed a modified intention-to-treat principle. The patients were randomized into three groups: Standard care without music (Control), therapist-designed classic music treatment (TT), or personal music intervention with patient-selected songs played ad libitum by the patient (PI). All patients received standard post-anesthesia care, and music intervention was started upon arrival at the post-anesthesia care unit. Primary outcomes were anxiety and overall satisfaction at discharge. In contrast, secondary outcomes were systolic blood pressure during music intervention, the sleep quality of the night after surgery, and the occurrence of postoperative nausea and vomiting within the first 24 hours after surgery. Results: Compared with therapist-designed music treatment, personal intervention decreased systolic blood pressure (T 0 : 124.3±13.7, 95%CI:121-127.7; T 20min : 117.6±10.4, 95%CI:115-120.1; T 30min : 116.9±10.6, 95%CI:114.3-119.4), prevented postoperative nausea and vomiting (Control: 55.9%, TT: 64.6%, PI: 77.6%), including severe postoperative nausea (VAS score&gt;4; Control:44.1%; TT:33.8%; PI:20.9%) and severe emesis (Frequency≥3, Control:13.2%; TT:7.7%; PI:4.5%). None of the treatments affected sleep quality at night after surgery (Median, Q1-Q3, Control:3,1-3; TT:3,1-4; PI:3,1-3.5). Personal, but not therapist, music intervention significantly prevented anxiety (Control: 36.4±5.9, 95% CI:35.0-37.9; TT: 36.2±7.1, 95%CI: 34.4-37.9; PI: 33.8±5.6, 95%CI: 32.4-35.2) and emesis (Control:23.9%; TT:23.4%; PI:13.2%) and improved patient satisfaction (Median, Q1-Q3, C:8, 6-8; TT:8,7-9; PI:8,7-9). Conclusions: Personal music intervention improved postoperative systolic blood pressure, anxiety, nausea, emesis, and overall satisfaction, but not sleep quality, as compared to therapist-designed classic intervention.
A commentary on “Global research status and frontiers on autophagy in hepatocellular carcinoma: A comprehensive bibliometric and visualized analysis”
Authors: Sike He, Hao Zeng
Journal: International Journal of Surgery (2024)

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. E-mail address: [email protected] (H. Zeng). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
A commentary on ‘Worldwide research trends on tumor burden and immunotherapy: A bibliometric analysis’
Authors: Lele Miao, Juan Zhang, Chaoyan Shen, Wei Wang
Journal: International Journal of Surgery (2024)

aDepartment of Thyroid and Breast Surgery, Jining NO.1 people' Hospital, Jining, China bDepartment of Hematology, Jining NO.1 people' Hospital, Jining, China cDepartment of Ultrasound, Jining NO.1 people' Hospital, Jining, China Lele Miao, Juan Zhang These three authors contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. *Corresponding author. Address: Jining NO.1 People's Hospital, Jining, Shandong Province, 272000, China. E-mail address: [email protected] (W. Wang). *Corresponding author. Address: Jining NO.1 People's Hospital, Jining, Shandong Province, 272000, China. E-mail address: [email protected] (C. Shen). Supplemental Digital Content is available for this article. Direct URL citations are provided in the HTML and PDF versions of this article on the journal's website, www.lww.com/international-journal-of-surgery. Published online ■ ■ This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
An MRI radiomics approach to discriminate hemorrhage prone intracranial tumors before stereotactic biopsy
Authors: Yupeng Zhang, Tingliang Cao, Haoyu Zhu, Yuqi Song, Changxuan Li, Chuhan Jiang, Chao Ma
Journal: International Journal of Surgery (2024)

Purpose: To explore imaging biomarkers predictive of intratumoral hemorrhage for lesions intended for elective stereotactic biopsy. Method: This study included a retrospective cohort of 143 patients with 175 intracranial lesions intended for stereotactic biopsy. All the lesions were randomly split into a training dataset (n=121) and a test dataset (n=54) at a ratio of 7:3. 34 lesions were defined as “hemorrhage-prone tumors” as hemorrhage occurred between initial diagnostic MRI acquisition and the scheduled biopsy procedure. Radiomics features were extracted from the contrast-enhanced T1WI and T2WI images. Features informative of hemorrhage were then selected by the LASSO algorithm and an SVM model was built with selected features. The SVM model was further simplified by discarding features with low importance calculated using a “permutation importance” method. The model’s performance was evaluated with confusion matrix-derived metrics and AUC value on the independent test dataset. Results: Nine radiomics features were selected as hemorrhage related features of intracranial tumors by the LASSO algorithm. The simplified model’s sensitivity, specificity, accuracy, and AUC reached 0.909, 0.930, 0.926, and 0.949 (95%CI: 0.865-1.000) on the test dataset in the discrimination of “hemorrhage-prone tumors”. The permutation method rated feature “T2_gradient_firstorder_10Percentile” as the most important, the absence of which decreased the model’s accuracy by 10.9%. Conclusion: Radiomics features extracted on contrast-enhanced T1WI and T2WI sequences were predictive of future hemorrhage of intracranial tumors with favorable accuracy. This model may assist in the arrangement of biopsy procedures and the selection of target lesions in patients with multiple lesions.
Long-term cardiovascular risk reduction after gastric cancer surgery: a nationwide cohort study
Authors: Yeongkeun Kwon, Dohyang Kim, Sangwoo Kim, Jane Ha, Jinseub Hwang, Sungsoo Park, Jin-Won Kwon
Journal: International Journal of Surgery (2024)

Gastrectomy for gastric cancer is associated with postoperative changes in cardiovascular risk factors, however, the impact of gastrectomy on cardiovascular events remains unclear. The authors assessed the incidence of cardiovascular events between patients undergoing gastrectomy or endoscopic resection for gastric cancer, and the general population.
Nomogram for predicting difficult total laparoscopic hysterectomy: A multi-institutional, retrospective model development and validation study
Authors: Yin Chen, Jiahong jiang, Min He, Kuiyan Zhong, Shuai Tang, Li Deng, Yanzhou Wang
Journal: International Journal of Surgery (2024)

Background: Total laparoscopic hysterectomy (TLH) is the most commonly performed gynecological surgery. However, the difficulty of the operation varies depending on the patient and surgeon. Subsequently, patient’s outcomes and surgical efficiency are affected. We aimed to develop and validate a pre-operative nomogram to predict the operative difficulty in patients undergoing TLH. Methods: This retrospective study included 663 patients with TLH from XXX Hospital and 102 patients from YYY Hospital in Chongqing, China. A multivariate logistic regression analysis was used to identify the independent predictors of operative difficulty, and a nomogram was constructed. The performance of the nomogram was validated internally and externally. Results: The uterine weight, history of pelvic surgery, presence of adenomyosis, surgeon’s years of practice, and annual hysterectomy volume were identified as significant independent predictors of operative difficulty. The nomogram demonstrated good discrimination in the training dataset (area under the receiver operating characteristic curve [AUC], 0.827 (95% confidence interval [CI], 0.783–0.872), internal validation dataset (AUC, 0.793 [95% CI, 0.714–0.872]), and external validation dataset (AUC, 0.756 [95% CI, 0.658–0.854]). The calibration curves showed good agreement between the predictions and observations for both internal and external validations. Conclusion: The developed nomogram accurately predicted the operative difficulty of TLH, facilitated pre-operative planning and patient counseling, and optimized surgical training. Further prospective multicenter clinical studies are required to optimize and validate this model.
A commentary on “Mapping the landscape of immunonutrition and cancer research: a comprehensive bibliometric analysis on behalf of NutriOnc research group”
Authors: Lin Wang, Yongcheng Wang, Xiao Li
Journal: International Journal of Surgery (2024)

aFirst Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China bDepartment of Cardiovascular Diseases, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China Lin Wang and Yongcheng Wang: Co-authors: These authors have contributed equally to this work. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Cardiovascular Diseases, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, Shandong, China. E-mail address: [email protected] (X. Li). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Effect of dexmedetomidine on the incidence of postoperative acute kidney injury in living donor liver transplantation recipients: a randomized controlled trial
Authors: Hye-Mee Kwon, Sa-jin Kang, Sang-Bin Han, Jae Hwan Kim, Sung-Hoon Kim, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang
Journal: International Journal of Surgery (2024)

Background: Acute kidney injury (AKI) is one of the most common complications after living-donor liver transplantation (LDLT) that has great impact on recipient and graft outcomes. Dexmedetomidine is reported to decrease the incidence of AKI. In the current study, the authors investigated whether intraoperative dexmedetomidine infusion would reduce the AKI following LDLT. Material and methods: In total, 205 adult patients undergoing elective LDLT were randomly assigned to the dexmedetomidine group ( n =103) or the control group ( n =102). Dexmedetomidine group received continuous dexmedetomidine infusion at a rate of 0.4 mcg/kg/h after the anesthesia induction until 2 h after graft reperfusion. The primary outcome was to compare the incidence of AKI. Secondary outcomes included serial lactate levels during surgery, chronic kidney disease, major adverse cardiovascular events, early allograft dysfunction, graft failure, overall mortality, duration of mechanical ventilation, intensive care unit, and hospital length of stay. Intraoperative hemodynamic parameters were also collected. Results: Of 205 recipients, 42.4% ( n =87) developed AKI. The incidence of AKI was lower in the dexmedetomidine group (35.0%, n =36/103) compared with the control (50.0%, n =51/102) ( P =0.042). There were significantly lower lactate levels in the dexmedetomidine group after reperfusion [4.39 (3.99–4.8) vs 5.02 (4.62–5.42), P =0.031] until the end of surgery [4.23 (3.73–4.74) vs 5.35 (4.84–5.85), P =0.002]. There were no significant differences in the other secondary outcomes besides lactate. Also, intraoperative mean blood pressure, cardiac output, and systemic vascular resistance did not show any difference. Conclusion: Our study suggests that intraoperative dexmedetomidine administration was associated with significantly decreased AKI incidence and lower intraoperative serum lactate levels in LDLT recipients, without untoward hemodynamic effects.
The role of robotic-assisted surgery in the management of rectal cancer: a systematic review and meta-analysis
Authors: Chenxion Zhang, Hao Tan, Han Xu, Jiaming Ding
Journal: International Journal of Surgery (2024)

Rectal cancer poses a significant global health burden. There is a lack of concrete evidence concerning the benefits of robotic-assisted surgery (RAS) for rectal cancer surgery as compared to laparoscopic and open techniques. To address this gap, we conducted a meta-analysis to assess the intraoperative, postoperative, and safety outcomes of robotic surgery in this context.
Perioperative outcomes and long-term survival of cryosurgery on unresectable pancreatic cancer: a systematic review and meta-analysis
Authors: Kang Xue, Xiaofeng Liu, Xiaolin Xu, Li Wang, Bole Tian
Journal: International Journal of Surgery (2024)

Background: Pancreatic cancer (PC) continues to rank as one of the deadliest forms of cancer, with the majority of patients being diagnosed with unresectable disease. The implementation of cryoablation-based comprehensive treatment is expected to lead to a reduction in tumor size and potentially achieve complete resection. However, the availability of systematic and evidence-based treatment guidelines for cryoablation in pancreatic cancer is currently limited. Materials and Methods: A computerized search was conducted in the Medline, Embase, Cochrane Library databases, and Clinicaltrials to retrieve studies published from August 1987 to June 2023. The perioperative outcomes and long-term survival of patients with locally advanced pancreatic cancer (LAPC) or metastatic pancreatic cancer (mPC) who underwent cryosurgery were systematically collected. Heterogeneity was assessed using the Cochran’s Q test, and a funnel plot was implemented to evaluate publication bias. Data were pooled and analyzed using Stata 14.0 software. The Newcastle-Ottawa Quality Assessment Form tool was employed for quality evaluation. Results: 9 studies including 368 patients were identified. The pooled overall incidence rate was 4% (95%CI: 0-14%; I²=54.06%) for acute pancreatitis, 0% (95%CI: 0-0%; I²=0.0%) for delayed gastric emptying, 0% (95%CI: 0-1%; I²=0.0%) for postoperative pancreatic fistula (POPF) or bile leakage, 2% (95%CI:0-5%; I²=0.0%) for bleeding, and 4% (95%CI: 0-12%; I²=70.46%) for fever. Our subgroup analysis revealed that the percutaneous treatment group had a lower incidence of complications compared to laparotomy, but had higher incidences of POPF, bleeding, and pancreatitis than the intraoperative group. Median overall survival (OS) varied from 5 to 16.2 months. The median survival rates at 6, 12, 24, and 36 months for patients who underwent cryosurgery were as follows: 94.9%, 64.8% (range: 4.8%–63.1%), 22.80%, and 9.5%, respectively. Conclusion: With the advancements in cryoablation and anti-tumor therapy, cryoablation emerges as a promising treatment modality for patients with unresectable pancreatic cancer. According to existing literature, the combination of cryoablation with radioactive particle implantation or immunotherapy has demonstrated considerable efficacy and safety. However, while the majority of included data is derived from retrospective studies, it is imperative to conduct larger sample sizes or prospective trials for further validation.
Intraoperative nerve monitoring reduces recurrent laryngeal nerve palsy in endoscopic thyroid surgery: A trial sequential analysis
Authors: Kuo-Chuan Hung, Wei-Ting Wang, I-Wen Chen
Journal: International Journal of Surgery (2024)

aDepartment of Anesthesiology, Chi Mei Medical Center, Tainan city, Taiwan bDepartment of Anesthesiology, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan cDepartment of Anesthesiology, Chi Mei Medical Center, Liouying, Tainan city, Taiwan Note: The affiliations for Kuo-Chuan Hung (affiliation 1) and I-Wen Chen (affiliation 3) represent different hospitals, despite both being under the Chi Mei Medical Center. These affiliations should not be combined or confused as they are distinct entities within different locations Short title: Nerve Monitoring and Laryngeal Nerve Palsy. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Anesthesiology, Chi Mei Medical Center, Liouying, Tainan city, Taiwan Chi Mei Medical Center, No.201, Taikang Taikang Vil., Liouying Dist., Tainan City 73657, Taiwan (R.O.C.) TEL: +886-6-281-2811 FAX: +886-6-283-3806. E-mail address: [email protected] (I-W. Chen). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/