THE MECHANISM AND PREVENTION OF CARDIOVASCULAR CHANGES DUE TO INSULIN
Authors: Richard A. Gilbert, Joseph W. Goldzieher
Journal: Annals of Internal Medicine (1946)

Article1 December 1946THE MECHANISM AND PREVENTION OF CARDIOVASCULAR CHANGES DUE TO INSULINRICHARD A. GILBERT, JOSEPH W. GOLDZIEHER, M.D.RICHARD A. GILBERTSearch for more papers by this author, JOSEPH W. GOLDZIEHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-6-928 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAside from troublesome hypoglycemic reactions insulin is generally considered a rather innocuous drug in therapeutic dosage. Joslin1and others2have alluded to dangers of insulin therapy in patients with cardiac disease, but very little attention has been paid to these warnings, and insulin is often dispensed to older diabetics in a care-free and almost routine fashion. Büdingen,3von Noorden4and others were impressed even at an early period by dangerous and sometimes fatal cases of anginal syndrome following insulin therapy in aging diabetics. Gigon5reported the sudden death of a diabetic with heart disease after the third injection of insulin....Bibliography1. JOSLINROOTWHITEMARBLE EPHFPA: The treatment of diabetes mellitus, 1940, Philadelphia. Google Scholar2. SOSKINKATZSTROUSERUBINFELD SLNSSH: The treatment of elderly diabetic patients with cardiovascular disease; available carbohydrate and blood sugar level, Arch. Int. Med., 1933, li, 122-142. CrossrefGoogle Scholar3. BÜDINGEN T: Zentralbl. f. Herzkrankh., 1925, xvii, 215-224 and 231-240. Google Scholar4. VON NOORDEN H: Die Zuckerkrankheit, 1927 (8th Ed.), p. 307. Google Scholar5. GIGON A: Diabetes und Insulintherapie, Klin. Wchnschr., 1923, ii, 1670-1671. Google Scholar6. SCHÖNBRUNNER E: Über ein Fall von Schädigung des Herzens durch Insulin, Med. Klin., 1935, xxxi, 1571-1572. Google Scholar7. 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BRANDTKATZ FG: Über den Nachweis von Adrenalinsekretion beim Menschen, Ztschr. f. klin. Med., 1933, clxxiii, 40-50. Google Scholar48. ASK-UPMARK E: Der Einfluss des Prostigmins auf das normale Elektrocardiogram, Ztschr. f. Kreislaufforsch., 1941, xxxiii, 41-48. Google Scholar49. LARSEN K: Effect of anoxemia on the human electrocardiogram, Acta med. Scandinav. (Suppl.) 1936, lxxviii, 141-149. Google Scholar50. TOLSTOIALMYTOSCANI ETPN: Treatment of diabetes mellitus with protamine insulin: is a persistent glycosuria harmful? Metabolic study of a severe case, Ann. Int. Med., 1942, xvi, 893-903. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North Carolina*Received for publication March 14, 1946.From the Second Medical Division, City Hospital, Welfare Island, N. Y., Department of Hospitals, New York, N. Y.†Now on active duty with the U. S. Army.‡Now at the Endocrine Division, Duke University Hospital, Durham, N. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypoglycaemia is more frequent in type 2 diabetic patients with co-morbid vascular disease: an analysis of the DiaRegis registryVascular disease and diabetes: is hypoglycaemia an aggravating factor?The mechanism of arrhythmias during insulin-induced hypoglycemiaKrankheiten der GefäßeTHE ASSOCIATION BETWEEN HYPOGLYCÆMIA AND MYOCARDIAL INFARCTIONA relationship between electrocardiographic changes and hypokalemia in insulin-induced hypoglycemiaCardiac complications of diabetes mellitusNeurohormanal bedingte Herzkrankheiten (Pathogenese und Therapie) 1 December 1946Volume 25, Issue 6Page: 928-940KeywordsAgingCardiovascular therapyDrug therapyDrugsEndocrine therapyHeart diseasesHypoglycemicsInsulin Issue Published: 1 December 1946 PDF downloadLoading ...