tbuckley/cabot-search huggingface dataset:
Registries on transcatheter edge‐to‐edge repair in heart failure: Current evidence and future perspectives
Authors: Gianluigi Savarese, Christian Basile, Marianna Adamo, Stefan D. Anker, Antoni Bayes‐Genis, Michael Böhm, Erwan Donal, Gerasimos S. Filippatos, Francesco Maisano, Piotr Ponikowski, Giuseppe M.C. Rosano, Ralph Stephan von Bardeleben, Marco Metra, Javed Butler
Journal: European Journal of Heart Failure (2025)

Abstract Aims Secondary mitral regurgitation (SMR) and tricuspid regurgitation (TR) are the most common valvular heart diseases in patients with heart failure (HF). Transcatheter edge‐to‐edge repair (TEER) devices designed for treating MR and TR have been successfully tested in randomized controlled trials, but methodological issues have often challenged their interpretation. This manuscript aimed to provide an overview of TEER registries on SMR and TR in HF, highlighting their key features, describing clinical characteristics and outcomes of patients receiving these devices, and exploring the available data limitations. Methods and results PubMed, Web of Science, and EMBASE were searched for registries reporting on TEER in SMR or TR. Registries were excluded if single‐centre and with &lt;100 patients. Twenty‐six registries (46% prospective, 12% ongoing), including a total cohort of 18 925 patients, were retrieved for TEER in SMR, and six registries (50% retrospective, 33% ongoing) reported on the use of TEER for TR in a total cohort of 1412 patients. Limited geographical representativity outside North America and Europe, high number of missing values, and inconsistency in data reporting were the main existing evidence limitations. Conclusion Registries on TEER represent a key data source in a setting where it is difficult to conduct randomized controlled trials. However, limitations in design, patient characterization, and outcomes reporting restrain their use. A novel conceptual framework for future prospective TEER registries, as proposed in this document, might inform current practice, address relevant clinical questions and future trial design.
Real-world effectiveness and safety of bulevirtide monotherapy for up to 96 weeks in patients with HDV-related cirrhosis
Authors: Elisabetta Degasperi, Maria Paola Anolli, Mathias Jachs, Thomas Reiberger, Victor De Ledinghen, Sophie Metivier, Gianpiero D'Offizi, Francesco di Maria, Christoph Schramm, Hartmut Schmidt, Caroline Zöllner, Frank Tacke, Christopher Dietz-Fricke, Heiner Wedemeyer, Margarita Papatheodoridi, George Papatheodoridis, Ivana Carey, Kosh Agarwal, Florian Van Bömmel, Maurizia R Brunetto, Mariana Cardoso, Gabriella Verucchi, Alessia Ciancio, Fabien Zoulim, Soo Aleman, Nasser Semmo, Alessandra Mangia, Marie-Noelle Hilleret, Uta Merle, Teresa A Santantonio, Nicola Coppola, Adriano Pellicelli, Bruno Roche, Xavier Causse, Louis D'Alteroche, Jérome Dumortier, Nathalie Ganne, Frederic Heluwaert, Isabelle Ollivier, Dominique Roulot, Mauro Viganò, Alessandro Loglio, Alessandro Federico, Francesca Pileri, Monia Maracci, Matteo Tonnini, Jean-Pierre Arpurt, Karl Barange, Eric Billaud, Stanislas Pol, Anne Gervais, Anne Minello, Isabelle Rosa, Massimo Puoti, Pietro Lampertico
Journal: Journal of Hepatology (2025)
MicroRNA Biomarkers and Host Response Pathways in Severe Pulmonary Hemorrhagic Syndrome due to Leptospirosis: A Multi-Omics Study
Authors: Phu Nguyen Trong Tran, Umaporn Limothai, Janejira Dinhuzen, Sasipha Tachaboon, Theerapon Sukmark, Chayomon Dokpong, Sittiruk Roytrakul, David A. Haake, Nattachai Srisawat
Journal: Journal of Infection (2025)

Highlights•MiR-5010-3p and miR-147b-3p are novel miRNA biomarkers of SPHS in patients with leptospirosis.•TNF signaling pathway is among the major host response mechanisms differentially enriched in SPHS patients.•Significant correlations were found between miRNA biomarkers and the expression profile of TNF signaling pathway proteins, suggesting the relevance of miRNA biomarkers in host response mechanisms.AbstractBackgroundSevere pulmonary hemorrhagic syndrome (SPHS) remains a fatal complication of leptospirosis with poorly understood mechanisms and an urgent need for effective biomarkers.MethodsA nested case-control analysis was conducted using blood specimens from two previous Thai leptospirosis cohorts. Candidate microRNAs were initially discovered through a global profiling of 798 serum microRNAs in five SPHS and seven non-SPHS patients, and then validated using real-time polymerase chain reactions in 168 patients. Pathways enriched from microRNA targets were compared to those from an integrated transcriptomic-proteomic analysis. Proteins pertaining to the key resulting pathway were measured to validate significance and reveal correlation with microRNA biomarkers.ResultsSerum microRNA profiling revealed a total of 81 significantly expressed microRNAs, of which seven were selected for further validation in the whole cohort of 168 leptospirosis patients, including 28 in SPHS and 140 nonSPHS groups. Among the selected microRNAs, miR-5010-3p and miR-147b-3p had significantly higher expression in SPHS group compared to nonSPHS group, with consistently higher expression after adjusting for age, sex, days of illness, comorbidity, smoking status or recruitment site. The two had area under the curve (AUC) values of 0.76 (95% CI: 0.67–0.85) and 0.70 (95% CI: 0.56–0.81) for discriminating SPHS, respectively. These microRNAs also exhibited consistent AUC values in patients tested before chest radiograph shadows manifested. Combination of miR-5010-3p with miR-548ai and miR-224-5p, as selected by Bayesian Model Average algorithm, substantially boosts the AUC value to 0.86 (95% CI: 0.77−0.94). The miRNA biomarkers also enhanced the predictive values of a previously validated clinical model, increasing AUC value from 0.87 to 0.92 with a significant reclassification net index. Multi-omics pathway analysis incorporating microRNA targets and transcriptomic-proteomic data suggested TNF signaling as among the key pathways. In validation, seven out of ten pathway proteins were significantly different between groups, with principal components correlated with severity and miR-5010-3p.ConclusionsMiR-5010-3p and miR-147b-3p are novel biomarkers with good predictability and potential relevance with TNF signaling pathway, an important host response mechanism in leptospirosis SPHS.Graphical abstract
Metabolic dysfunction‐associated steatotic liver disease is associated with increased risks of heart failure
Authors: Kai‐Chun Chang, Tung‐Hung Su, Cho‐Kai Wu, Shang‐Chin Huang, Tai‐Chung Tseng, Chun‐Ming Hong, Shih‐Jer Hsu, Chen‐Hua Liu, Hung‐Chih Yang, Chun‐Jen Liu, Jia‐Horng Kao
Journal: European Journal of Heart Failure (2025)
Highlighted Research Articles
Journal: Blood Cancer Discovery (2025)

In This Issue| January 08 2025 Highlighted Research Articles Author & Article Information Online ISSN: 2643-3249 Print ISSN: 2643-3230 ©2024 American Association for Cancer Research2024American Association for Cancer Research Blood Cancer Discov (2025) 6 (1): 4. https://doi.org/10.1158/2643-3230.BCD-6-1-ITI Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record January 8 2025 Citation Highlighted Research Articles. Blood Cancer Discov 1 January 2025; 6 (1): 4. https://doi.org/10.1158/2643-3230.BCD-6-1-ITI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Bridging therapy (BT) is warranted in the majority of relapsed/refractory multiple myeloma patients before CAR-T cell infusion. In this work, Fandrei and colleagues characterized the impact of bispecific T cell–engaging antibodies (BsAb), chemotherapy, anti-CD38, and anti-SLAMF7 antibody-based bridging options. Depth of response to BT was associated with progression-free survival, and BsAbs showed the highest overall response rate to BT. There was no difference in total CAR-T cell expansion with BsAbs compared to other regimens. Single-cell RNA- and TCR-sequencing revealed increased clonality of T-cell effector subsets after bridging with BsAbs. These findings suggest that BsAbs are a safe and feasible bridging option. See article, p. 28. No single antigen in acute myeloid leukemia (AML) has been successfully and safely targeted by immunotherapy due to on-target, off-cancer toxicity to essential healthy cell types, including hematopoietic stem and progenitor cells (HSPC). To tackle this, increased specificity to AML cells can be potentially... You do not currently have access to this content.
Photo‐Facilitated Nitric Oxide‐Triggered Turn‐on Photodynamic Therapy for Precise Antitumor Application
Authors: Yiliang Qin, Hanyi Gao, Yuting Yin, Jiayi Li, Xia He, Meng Gao, Liying Sun, Yi Yuan, Ying Tian, Yizhao Zhou, Zebing Zeng, Xiaodong Zhang, Rong Hu
Journal: Advanced Healthcare Materials (2025)

Abstract Photodynamic therapy (PDT) is a powerful strategy for tumor therapy with noninvasiveness and desirable efficacy. However, the phototoxicity of photosensitizer after the post‐PDT is the major obstacle limiting the clinic applications. Herein, a nitric oxide (NO)‐activatable photosensitizer is reported with turn‐on PDT behavior and endoplasmic reticulum (ER) targeting ability for precise tumor therapy. Four o ‐thiophenediamine derivatives with reaction‐tunable donor/acceptor push‐pull electronic effect are established, and the systematic structure and property relationship observation reveals the following features: 1) the reactivity against NO can be improved by enhancing the electron density and further facilitated upon photo‐irradiation. 2) the reactivity with NO enables the improved intramolecular charge transfer process with the evoking of photosensitizing effect. 3) only o ‐thiophenediamine derivative with ER enrichment behavior exhibited cancer cell ablation effect compared to photosensitizers localized in lysosome and lipid droplet. Thus, the efficient inhibition of cancer cells both in vitro and in vivo is realized based on the photo‐controlled PDT strategy. This work provides more insights into developing promising activatable photosensitizers for advanced therapy based on tumor microenvironment trigger.
Metal‐Protein Hybrid Materials: Unlocking New Frontiers in Biomedical Applications
Authors: Yong Pan, Han Zhao, Wenyong Huang, Siyang Liu, Yanxin Qi, Yubin Huang
Journal: Advanced Healthcare Materials (2025)

Abstract Metal‐protein hybrid materials represent a novel class of functional materials that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including materials engineering, biocatalysis, biosensing, and biomedicine. The design and development of multifunctional and biocompatible metal‐protein hybrid materials have been the subject of extensive research and a key aspiration for practical applications in clinical settings. This review provides a comprehensive analysis of the design strategies, intrinsic properties, and biomedical applications of these hybrid materials, with a specific emphasis on their potential in cancer therapy, drug and vaccine delivery, antibacterial treatments, and tissue regeneration. Through rational design, stable metal‐protein hybrid materials can be synthesized using straightforward methods, enabling them with therapeutic, delivery, immunomodulatory, and other desired functionalities. Finally, the review outlines the existing limitations and challenges associated with metal‐protein hybrid materials and evaluates their potential for clinical translation, providing insights into their practical implementation within biomedical applications.
Understanding GABAergic synapse diversity and its implications for GABAergic pharmacotherapy
Authors: Dilja Krueger-Burg
Journal: Trends in Neurosciences (2025)

Despite the substantial contribution of disruptions in GABAergic inhibitory neurotransmission to the etiology of psychiatric, neurodevelopmental, and neurodegenerative disorders, surprisingly few drugs targeting the GABAergic system are currently available, partly due to insufficient understanding of circuit-specific GABAergic synapse biology. In addition to GABA receptors, GABAergic synapses contain an elaborate organizational protein machinery that regulates the properties of synaptic transmission. Until recently, this machinery remained largely unexplored, but key methodological advances have now led to the identification of a wealth of new GABAergic organizer proteins. Notably, many of these proteins appear to function only at specific subsets of GABAergic synapses, creating a diversity of organizer complexes that may serve as circuit-specific targets for pharmacotherapies. The present review aims to summarize the methodological developments that underlie this newfound knowledge and provide a current overview of synapse-specific GABAergic organizer complexes, as well as outlining future avenues and challenges in translating this knowledge into clinical applications.
Patient-Specific Hematologic Setpoints Inform Diagnosis and Prognosis
Journal: Cancer Discovery (2025)

Main Findings: Complete blood count indices are patient-specific and stable over decades in healthy adults.Concept: These hematologic setpoints are deep physiological phenotypes associated with variation in clinical risk.Impact: A deeper understanding of patient-specific setpoints may inform the management of many common conditions, including myeloproliferative neoplasms.
Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner
Authors: Wenxiang Qing, Huimin Chen, Xin Ma, Jie Chen, Yuan Le, Hui Chen, Jianhua Tong, Kaiming Duan, Daqing Ma, Wen Ouyang, Jianbin Tong
Journal: Gut Microbes (2025)

Chronic stress can result in various conditions, including psychological disorders, neurodegenerative diseases, and accelerated brain aging. Gut dysbiosis potentially contributes to stress-related brain disorders in individuals with chronic stress. However, the causal relationship and key factors between gut dysbiosis and brain disorders in chronic stress remain elusive, particularly under non-sterile conditions. Here, using a repeated restraint stress (RRS) rat model, we show that sequential transplantation of the cecal contents of different RRS stages to normal rats reproduced RRS-induced core phenotypes, including abnormal behaviors, increased peripheral blood corticosterone and inflammatory cytokines, and a unique gut microbial phenotype. This core phenotypic development was effectively inhibited with probiotic supplement. The RRS-induced unique gut microbial phenotypes at the genus level were positively or negatively associated with the levels of 20 plasma metabolites, including vitamin B6 metabolites 4-pyridoxic acid and 4-pyridoxate. Vitamin B6 supplement during RRS alleviated weight loss, abnormal behaviors, peripheral inflammation, and neuroinflammation, but did not affect the peripheral corticosterone levels in chronic stressed rats. Dampening inflammatory signaling via knocking out caspase 11 or caspase 1 inhibitor abolished RRS-induced abnormal behaviors and peripheral and neuroinflammation but did not decrease peripheral corticosterone in mice. These findings show that gut dysbiosis-induced vitamin B6 metabolism disorder is a new non-hypothalamic-pituitary-adrenal axis mechanism of chronic stress-related brain disorders. Both probiotics and vitamin B6 supplement have potential to be developed as therapeutic strategies for preventing and/or treating chronic stress-related illness.
Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism
Authors: Naika Prince, Lucia N. Peralta Marzal, Léa Roussin, Magali Monnoye, Catherine Philippe, Elise Maximin, Sabbir Ahmed, Karoliina Salenius, Jake Lin, Reija Autio, Youri Adolfs, R. Jeroen Pasterkamp, Johan Garssen, Laurent Naudon, Sylvie Rabot, Aletta D. Kraneveld, Paula Perez-Pardo
Journal: Gut Microbes (2025)

Several factors are linked to the pathophysiology of autism spectrum disorders (ASD); however, the molecular mechanisms of the condition remain unknown. As intestinal problems and gut microbiota dysbiosis are associated with ASD development and severity, recent studies have focused on elucidating the microbiota-gut-brain axis' involvement. This study aims to explore mechanisms through which gut microbiota might influence ASD. Briefly, we depleted the microbiota of conventional male BALB/cAnNCrl (Balb/c) and C57BL/6J (BL/6) mice prior to human fecal microbiota transplantation (hFMT) with samples from children with ASD or their neurotypical siblings. We found mouse strain-specific responses to ASD hFMT. Notably, Balb/c mice exhibit decreased exploratory and social behavior, and show evidence of intestinal, systemic, and central inflammation accompanied with metabolic shifts. BL/6 mice show less changes after hFMT. Our results reveal that gut microbiota alone induce changes in ASD-like behavior, and highlight the importance of mouse strain selection when investigating multifactorial conditions like ASD.
Nutritional optimization of fecal microbiota transplantation in humans: a scoping review
Authors: Levi M Teigen, Austin Hoeg, Hijab Zehra, Priyali Shah, Remy Johnson, Kristen Hutchison, Megan Kocher, Annie W Lin, Abigail J Johnson, Byron P Vaughn
Journal: Gut Microbes (2025)

Diet constitutes a major source of nutrient flow to the gut microbes. As such, it can be used to help shape the gut microbiome. Fecal microbiota transplantation (FMT) is an increasingly promising therapy in disease states beyond recurrent Clostridioides difficile infection, but diet is largely overlooked for its potential to help optimize this therapy. Therefore, the aim of this scoping review is to present the literature landscape that captures pre- and post-FMT dietary intake in humans, identify research gaps, and provide recommendations for future research. A comprehensive search strategy was developed and searches were run in five databases. Studies were included if they discussed adults who underwent FMT for any recognized treatment indication and had dietary intake as a study objective, this search encompassed studies with interventions that included foods and dietary supplements. The initial screening identified a total of 7721 articles, of which 18 met the inclusion criteria for this review. Studies were heterogeneous, but taken together, they introduce a framework that defines important nutritional considerations for both donors and FMT recipients in the period around FMT dosing. This framework is summarized with this review and highlights the opportunities available to develop FMT-based precision nutrition strategies to optimize its clinical efficacy.
Comment on: 2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases
Authors: Julian Segan, Michael Putman, Richard Conway
Journal: Arthritis & Rheumatology (2025)

Disclosure Form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The Last Decade in Cardiac Amyloidosis
Authors: Marianna Fontana, Adam Ioannou, Sarah Cuddy, Sharmila Dorbala, Ahmad Masri, James C Moon, Vasvi Singh, Olivier Clerc, Mazen Hanna, Fredrick Ruberg, Martha Grogan, Michele Emdin, Julian Gillmore
Journal: JACC. Cardiovascular imaging (2025)

Cardiac amyloidosis represents a unique disease process characterized by amyloid fibril deposition within the myocardial extracellular space. Advances in multimodality cardiac imaging enable accurate diagnosis and facilitate prompt initiation of disease-modifying therapies. Furthermore, rapid advances in multimodality imaging have enriched understanding of the underlying pathogenesis, enhanced prognostication, and resulted in the development of imaging-based markers that reflect the amyloid burden, which is of increasing importance when assessing the response to treatment. Whereas conventional therapies have focused on reducing amyloid formation and subsequent stabilization of the cardiac disease process, novel agents are being developed to accelerate the immune-mediated removal of amyloid fibrils from the heart. In this context, the ability to track changes in the amyloid burden over time is of paramount importance. Although advanced imaging techniques have shown efficacy in tracking the treatment response, future research focused on improved precision through use of artificial intelligence may augment the detection of changes earlier in the course of treatment.
Standardized patient profile review using large language models for case adjudication in observational research
Authors: Martijn J. Schuemie, Anna Ostropolets, Aleh Zhuk, Uladzislau Korsik, Seung In Seo, Marc A. Suchard, George Hripcsak, Patrick B. Ryan
Journal: npj Digital Medicine (2025)

Abstract Using administrative claims and electronic health records for observational studies is common but challenging due to data limitations. Researchers rely on phenotype algorithms, requiring labor-intensive chart reviews for validation. This study investigates whether case adjudication using the previously introduced Knowledge-Enhanced Electronic Profile Review (KEEPER) system with large language models (LLMs) is feasible and could serve as a viable alternative to manual chart review. The task involves adjudicating cases identified by a phenotype algorithm, with KEEPER extracting predefined findings such as symptoms, comorbidities, and treatments from structured data. LLMs then evaluate KEEPER outputs to determine whether a patient truly qualifies as a case. We tested four LLMs including GPT-4, hosted locally to ensure privacy. Using zero-shot prompting and iterative prompt optimization, we found LLM performance, across ten diseases, varied by prompt and model, with sensitivities from 78 to 98% and specificities from 48 to 98%, indicating promise for automating phenotype evaluation.
False-Positive Uptake of 123I-MIBG in the Basal Ganglion in a Pediatric Neuroblastoma Patient
Authors: Yanfeng Xu, Siqi Li, Xia Lu, Wei Wang, Jigang Yang
Journal: Clinical Nuclear Medicine (2025)

Abstract A 7-year-old boy with high-risk neuroblastoma underwent 123 I-MIBG SPECT/CT to evaluate the therapy response. The scan revealed abnormal 123 I-MIBG uptake in the left basal ganglion, indicating the possibility of brain metastasis. Subsequent contrast-enhanced brain MRI, however, did not show any abnormal signal intensity in the left basal ganglion. Follow-up 123 I-MIBG SPECT/CT scans at 3-month and 9-month also did not show abnormal MIBG uptake in the same area. The case highlights the possibility of false-positive uptake of 123 I-MIBG in the basal ganglion.
18F-FAZA, 18F-FDG, and 123I-IMP Imaging Reveal Hypoxia and Metabolism in Acute MOGAD
Authors: Kota Yokoyama, Junichi Tsuchiya, Hiroya Kuwahara, Motoki Inaji, Ukihide Tateishi
Journal: Clinical Nuclear Medicine (2025)

Abstract We report the first case of myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) evaluated with hypoxic imaging using 18 F-FAZA PET/CT. A healthy woman in her 20s presented to our hospital with seizures, headaches, and vomiting. MRI and CT scans suggested a wide range of differential diagnoses, from neoplastic lesions, such as malignant lymphoma, to inflammatory diseases, such as vasculitis, making her case challenging to diagnose. MOGAD was confirmed by positive myelin oligodendrocyte glycoprotein antibodies, and her condition improved with steroid therapy. The 18 F-FAZA PET/CT findings in this case may aid in understanding the pathogenesis of MOGAD.