tbuckley/cabot-search huggingface dataset:
American Health Directory.
Authors: Henry Hatton
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 10959: Can the Preoperative Assessment of Genetic Polymorphisms for Cytokines Reliably Predict Clinical Events Induced by the Post-Cardiopulmonary Bypass Inflammatory Response?
Authors: Jerome Jouan, Lisa Golmard, Ludovic Trinquart, Nicolas Durrleman, Eric Tartour, Xavier Jeunemaitre, Jean-Noel Fabiani, Philippe Menaschee
Journal: Circulation (2010)

Background:  The inflammatory response induced by cardiopulmonary bypass (CPB) is still accountable for severe post-operative complications. Recent genetic studies have assessed the  individual  implication of single nucleotide polymorphisms (SNPs) of cytokines and apolipoprotein E in the magnitude of this response but the clinical relevance of these findings remains uncertain. We therefore studied the relationship between  several  SNPs, the corresponding cytokine circulating levels and postoperative clinical events in patients who underwent coronary artery bypass grafting (CABG) under CPB.   Methods:  We prospectively analyzed 126 consecutive patients referred for elective CABG. Patients were genotyped for SNPs of TNFβ ( Arg13Cys, +252A>G ), TNFα ( -308G>A ), IL6 ( -597A>G, −572G>C, −174G>C ), IL10 ( -592C>A, c*117C>T ), and apoE ( Cys112Arg, Arg158Cys ). Serum samples were retrieved at different perioperative time points to measure cytokine levels. The Primary Clinical Endpoint (PCE) was a composite of postoperative death, low cardiac output, myocardial infarction, acute respiratory distress syndrome, hepatic insufficiency, sepsis, or acute renal insufficiency. The Secondary Clinical Endpoint (SCE) extended PCE to include diuresis  2 /FiO 2   1L/24h.   Results:  In multivariate analysis, neither SNPs nor serum cytokine levels were predictive for PCE. Only patients homozygous for  IL6-174GG  were found to have a reduced incidence of the SCE (p=0.02) whereas this risk was higher for those carrying  TNFβ+252 AA-AG  (p   Conclusions:  Genomic determination of SNPs for cytokines predominantly involved in the postCPB inflammatory response seems to only have a limited predictive value of clinically relevant postoperative complications. Consequently this mode of screening is unlikely to really impact the perioperative management of patients undergoing on-pump CABG surgery.
发热-气短-咳嗽-浮肿
Authors: 刘浩, 沈敏, 田新平
Journal: BMJ (2010)

患者女，37岁，因“发热、胸痛、双下肢水肿25d”于2009年12月8日入院。患者于25d前无诱因出现发热，最高39℃，伴畏寒、寒战。伴心前区及胸骨下段疼痛，持续性，与呼吸相关，无咳嗽、咯痰。于外院查X线胸片示“双肺下野片状模糊影，考虑肺炎”，予美洛西林抗感染治疗，无缓解。继之出现呼吸困难，夜间不能平卧，上2层楼即感气短．伴干咳，双下肢可凹性水肿，无尿量减少。18d前出现心悸，
Study to see the efficacy and toxicity profile of docetaxel-based chemotherapy in advanced stomach cancer in Bangladeshi patient population
Authors: E. Hoque, S. Karim, M. Hossen, T. U. Ahmed
Journal: Journal of Clinical Oncology (2009)

e15687 Background: Gastric cancer is the second most common cause of cancer death worldwide. In Bangladesh it is one of the major causes of cancer death. Advanced gastric cancer patients have a poor prognosis of 3 to 5 months. Docetaxel has shown activity against gastric cancer as monotherapy and in combination with other agents. The purpose of this study was to investigate the efficacy and toxicity profile of docetaxel based chemotherapy in advanced stomach cancer in Bangladeshi patient population. Methods: From January 2004 to December 2006, thirty patients with advanced inoperable gastric cancer (Gastric or esophagogastric adenocarcinoma) were included in the study. Patients received no prior chemotherapy. Patients were given docetaxel 75mg/m 2 I/V in 1 hour infusion and Cisplatin 75mg/m 2 (d1) plus 5-fluorouracil 750mg/m 2 /d (days 1 to 5) I/V with adequate hydration every 3 weeks. The primary end point was time to tumour progression. Secondary end point was overall survival and toxicity profile. Results: Among the 30 evaluable patients time to tumour progression was 11.5 months. Overall response rate was 87% (26 patients). Complete response rate was 20% (6 patients), 27% (8 patients) had stable disease, 7% (2 patients) had developed progressive disease. Two-year survival rate was 21%. Grade 3 to 4 treatment related adverse events occurred in 63%. Among the toxicities there were: neutropenia (80%), stomatitis (19%), and diarrhea (15%). There was no treatment related death. Conclusions: Adding docetaxel to CF regimen significantly improved time to tumour progression and survival rate in advanced gastric cancer patients. In context with the survival benefit the toxicities of this regimen are acceptable. Docetaxel in combination with Cisplatin and 5-fluorouracil is a very safe and active in patients of Bangladesh with advanced gastric cancer. Larger studies involving higher number of patients are needed to evaluate these results in case of Bangladeshi patient population. No significant financial relationships to disclose.
Abstract 16030: Heterogeneity of Electrocardiographic Findings in Cardiac Transthyretin (ATTR) Amyloidosis and Impact on Survival
Authors: Ketna S Patel, Marianna Fontana, Sajitha Sachchithanantham, Rabya Sayed, Ashutosh D Wechalekar, Helen J Lachmann, Philip N Hawkins, Carol J Whelan, Julian D Gillmore
Journal: Circulation (2014)

Introduction: Cardiac transthyretin (ATTR) amyloidosis is an increasingly diagnosed cause of heart failure. Wild-type ATTR amyloidosis (ATTRwt) is a disease of older Caucasian men. Hereditary (mutant) cardiac ATTR amyloidosis (ATTRm) is most commonly associated with the V122I transthyretin (TTR) variant carried by 3-4% of African Americans or the T60A TTR variant in patients of Irish ancestry, the latter presenting with a mixed cardiac and neurologic phenotype. Most published data consider electrocardiographic (ECG) findings in ATTR amyloidosis as a single entity. Prognostic factors for survival in cardiac ATTR amyloidosis are poorly defined. Methods and Results: We analysed ECGs from 158 patients with cardiac ATTR amyloidosis (ATTRwt=75; V122I=49; T60A=34) in a longitudinal retrospective study. Results are shown in Table 1. 63 patients died; 29 ATTRwt, 24 V122I, 10 T60A, during follow-up of 22.7±14.6, 23.8±12.8, and 31.3±20.4 months respectively. Overall median survival: ATTRwt 3.1yr (95%CI:2.2-4.0); V122I 2.6 yr (95%CI:2.2-3.0); T60A not reached. In ATTRwt, broad QRS (≥120ms) was associated with worse survival (1.6yr; 95%CI:1.3-1.9 vs not reached). No other ECG parameter in ATTRwt, and none in either ATTRm group affected survival. On univariate analysis of the ATTRwt cohort, broad QRS, age, systolic BP, TropT and NTproBNP were significant variables at the &lt;1% level, and eGFR at the 5% level; LVEF, septal S’ TDI and global longitudinal strain were not significant. On multivariate analysis only broad QRS (HR: 3.0, CI 1.2-7.5; P=0.024) and NTproBNP (HR: 3.0, CI 1.1-7.4; P=0.026) predicted mortality. Among ATTRwt patients, there were no significant differences of other characteristics between those with narrow and those with broad QRS complexes. Conclusions: The ECG in cardiac ATTR amyloidosis is heterogeneous, greater awareness of which might help prevent diagnostic delays. Broad QRS complexes and NTproBNP are independent predictors of mortality in ATTRwt.
The Blood Vessels of the Human Skin and Their Responses.
Authors: Lewis, Thomas, Sir
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluating angiogenic cytokines VEGF, basic FGF and TGF- β1 as tumor markers in ascites
Authors: I. L. Nascimento, H. S. Barbosa, R. E. Schaer, D. C. Lemaire, S. M. Freire, V. Vale, M. L. Salomao, G. S. Lessa, R. J. Meyer
Journal: Journal of Clinical Oncology (2005)

9627 Background: To differentiate between malignant and nonmalignant ascites is an important clinical problem for further diagnostic and therapeutic procedures. As the majority of angiogenic factors are soluble peptides secreted by tumors, their use have been proposed as tumor markers in effusions. Three angiogenic cytokines were dosed in ascites samples - Vascular Endothelial Growth Factor (VEGF), basic Fibroblast Growth Factor (bFGF) and Transforming Growth Factor - β1 (TGF- β1) - to evaluate their ability to discriminate malignant and nonmalignant etiologies and to establish a correlation between the three growth factors in these two groups. Methods: A total of 63 (32 malignant and 31 nonmalignant) ascites samples obtained from paracentesis were used. Concentrations of VEGF, basic FGF and TGF-β1 in ascites were determined with ELISA (Quantikine, R&D Systems) following the manufacturer’s guidelines and the samples were analyzed in duplicate. Differences between the two groups were tested with nonparametric Mann-Whitney U Test and the correlation between the cytokines was evaluated by Spearmann coefficient. Results: Significantly higher concentrations of VEGF were detected in ascites from patients with cancer, median = 1,265.9 pg/mL, than without cancer, median= 114.1pg/mL, P< 0.0001. Using a ROC curve a 662 pg/mL cut-off value was chosen and a 72% sensibility and 90% specificity was obtained. Only a borderline significant difference between the bFGF levels in malignant and nonmalignant ascites (P value=0.053) had been found, and the ROC curve did not established acceptable values either for sensitivity or specificity. However, when ascites samples from tuberculosis were excluded a significant difference between the two groups was detected and the same was observed in regard to the samples from ovarian cancer compared to those from other neoplasias. TGF-β1 median values were not significantly different between the two groups and once again the ROC curve failed to determine adequate values of sensitivity or specificity. No correlation between the three cytokines studied was found. Conclusions: VEGF but not basic FGF or TGF-β1 is a valuable tumor marker to discriminate between malignant and nonmalignant ascites. No significant financial relationships to disclose.
Textbook of Adult and Pediatric Echocardiography and Doppler
Authors: Martin St. John Sutton, Paul Oldershaw
Journal: Annals of Internal Medicine (1989)

Physics and principles of echocardiography physics and principles of colorflow mapping and annular array transducers practical recording of echocardiography and Doppler echocardiography echophonocardiography contrast echocardiography echo image analysis by computer - M-mode echo image analysis by computer - 2D tissue characterization, back scatter, acoustic impedance, color encoded an integrated approach to the non-invasive assessment of left ventricular systolic and diastolic performance assessment of right ventricular function by echo clinical use of Doppler echocardiography atrio-ventricular valve disease semilunar valve disease prothetic valves and malfunction myocardial disease, ischemia myocardial disease, nonischemic pericardial disease intracardiac masses extracardiac vascular abnormalities echocardiograph sequential chamber analysis and pathoanatomic correlations fetal growth, shape, and cardiogenesis and the newborn systemic venous anomalies total anomalous pulmonary venous connection atrioseptal defects assessment of univentricular-atrioventricular connection discordant atrioventricular connections ebstein's malformation of the tricuspid valve right ventricular outflow tract obstruction complete transposition double outlet right ventricle left ventricular and right ventricular hypoplasia aortic anomalies.
The Biochemistry of Alkaloids.
Authors: Kurt Mothes, Horst Robert Schütte, Martin Luckner, H. Böhm
Journal: Annals of Internal Medicine (1969)

Historical Introduction Methods in Biosynthetical Research The Biochemical Genetics of Alkaloids Regulation of Alkaloid Metabolism Compartmentation and Channelling in Alkaloid Biosynthesis Storage of Alkaloids The Ecological Significance of Alkaloids Metabolism of Amino Acids Related to Alkaloid Biosynthesis Basic Principles of Alkaloid Biosynthesis Alkaloids Derived from Ornithine Lysine-derived Alkaloids Alkaloids Derived from Nicotinic Acid Alkaloids Derived from Tyrosine and Phenylalanine Alkaloids Derived from Tryptophan Alkaloids Derived from Anthranilic Acid Alkaloids Derived from Purines Alkaloids Formed from Histidine Isoprenoid Alkaloids.
Paired Serum and Urine Concentrations of Biomarkers of Diethyl Phthalate, Methyl Paraben, and Triclosan in Rats
Authors: Susan L. Teitelbaum, Qian Li, Luca Lambertini, Fiorella Belpoggi, Fabiana Manservisi, Laura Falcioni, Luciano Bua, Manori J. Silva, Xiaoyun Ye, Antonia M. Calafat, Jia Chen
Journal: Environmental Health Perspectives (2015)

Exposure to environmental chemicals, including phthalates and phenols such as parabens and triclosan, is ubiquitous within the U.S. general population.This proof-of-concept rodent study examined the relationship between oral doses of three widely used personal care product ingredients [diethyl phthalate (DEP), methyl paraben (MPB), and triclosan] and urine and serum concentrations of their respective biomarkers.Using female Sprague-Dawley rats, we carried out two rounds of experiments with oral gavage doses selected in accordance with no observed adverse effect levels (NOAELs) derived from previous studies: 1,735 (DEP), 1,050 (MPB), 50 (triclosan) mg/kg/day. Administered doses ranged from 0.005 to 173 mg/kg/day, 10-100,000 times below the NOAEL for each chemical. Controls for the MPB and triclosan experiments were animals treated with olive oil (vehicle) only; controls for the DEP serum experiments were animals treated with the lowest doses of MPB and triclosan. Doses were administered for 5 days with five rats in each treatment group. Urine and blood serum, collected on the last day of exposure, were analyzed for biomarkers. Relationships between oral dose and biomarker concentrations were assessed using linear regression.Biomarkers were detected in all control urine samples at parts-per-billion levels, suggesting a low endemic environmental exposure to the three chemicals that could not be controlled even with all of the precautionary measures undertaken. Among the exposed animals, urinary concentrations of all three biomarkers were orders of magnitude higher than those in serum. A consistently positive linear relationship between oral dose and urinary concentration was observed (R2 > 0.80); this relationship was inconsistent in serum.Our study highlights the importance of carefully considering the oral dose used in animal experiments and provides useful information in selecting doses for future studies.Teitelbaum SL, Li Q, Lambertini L, Belpoggi F, Manservisi F, Falcioni L, Bua L, Silva MJ, Ye X, Calafat AM, Chen J. 2016. Paired serum and urine concentrations of biomarkers of diethyl phthalate, methyl paraben, and triclosan in rats. Environ Health Perspect 124:39-45; http://dx.doi.org/10.1289/ehp.1409586.
Metastatic melanoma in the elderly: Case series of clinical outcome and immune characteristics
Authors: U. P. Hegde, N. Chakraborty, A. Chhabra, S. Ray
Journal: Journal of Clinical Oncology (2009)

e20018 Background: Cutaneous melanoma incidence is rapidly rising in the elderly population. Imbalances of the immune system are described due to aging associated changes between CD4+, CD8+, T helper (Th) 1, Th 2 and T regulatory and T effector lymphocytes (lym). We describe clinical outcome in 10 elderly patients (pts) with cutaneous metastatic melanoma (CMM) and results of the immune studies done in a subgroup. Methods: Between October 2002 and October 2008, 10 elderly pts with treatment naïve CMM, 6 males and 4 female, median ages 76, range 57–84 years were treated at the University of Connecticut Health Center. Metastatic sites included soft tissue in 2 patients (pts), lung and/or liver with lymph node (LN) involvement (6 pts) and distant LN metastasis (2pts). Eight pts opted for treatment and received single or combination chemotherapy (5pts), high dose Interleukin 2 (2 pts), complete tumor resection followed by tumor derived heat shock protein vaccine (1 pt on clinical trial) and bio chemotherapy (1pt). One patient declined treatment (included in follow up). In vitro immune characteristics were studied in HLA-A2 positive subgroup (5pts) and included cytotoxic T lym (CTL) generation against self and non self peptides (Mart-1 27–35 and influenza MP derived peptide flu 58–66), proliferative activity of CD4+ lym in response to anti CD3 antibody under Th1 and Th2 conditions and regulatory T lym activity of CD4+CD25+ lym against CTL. Results: All patients tolerated treatments well resulting in 1 complete response, 4 partial responses, and 4 stable diseases. During 6 year follow up period, 6 patients died while 4 patients are living (one with disease). The median survival of all patients is 28.1 month (mo) while in those surviving (4pts) is 72 mo. Immune studies revealed preserved proliferative activity of CD4+ lym with stronger Th1 induction than Th2. The CTL responses to self and non self antigens were preserved while regulatory T lym showed weak activity against CTL. Conclusions: Some elderly patients with metastatic melanoma demonstrate improved outcomes and favorable immune characteristics. Further studies are needed to understand the impact of aging immune system on cutaneous melanoma. No significant financial relationships to disclose.
Die Bestimmung des Astigmatismus durch die Schattenprobe mit Cylindergläsern.
Authors: K. Linder
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Validity of the Surface Electrocardiogram Criteria for Right Ventricular Hypertrophy
Authors: Isaac R. Whitman, Vickas V. Patel, Elsayed Z. Soliman, David A. Bluemke, Amy Praestgaard, Aditya Jain, David Herrington, Joao A.C. Lima, Steven M. Kawut
Journal: Journal of the American College of Cardiology (2013)
Abstract 15017: NLRP3 Inflammasome Activation Through the Heart-Brain Interaction Contributes to Adaptive Cardiac Hypertrophy in Response to Pressure Overload
Authors: Yasutomi Higashikuni, Ryozo Nagai, Masataka Sata, Issei Komuro
Journal: Circulation (2013)

Background: We have shown that interleukin-1β (IL-1β) upregulation via activation of Toll-like receptor 2 signaling contributes to adaptive cardiac hypertrophy in response to pressure overload. IL-...
Abstract 12353: Genetic Basis of Left Ventricular Noncompaction
Authors: Fukiko Ichida, Yukiko Hata, Bo Chang, Sayaka Ozawa, Kazuyoshi Saito, Keijiro Ibuki, Kazuhiro Watanabe, Heiichi Hirono, Naoki Nishida, Neil E Bowles, Toshio Miyawaki
Journal: Circulation (2011)

Purpose The purpose of this study was to investigate patients with Left ventricular noncompaction( LVNC) for mutations and investigate the role of SCN5A variants as phenotypic modifiers. Methods We...
Abstract 3029: Major Impact of Genetic and Physiologic Variables on Ischemia/reperfusion Injury in the Murine Heart
Authors: Yiru Guo, Michael P Flaherty, Wen-Jian Wu, Wei Tan, Xiaoping Zhu, Tao Wang, Qianhong Li, Roberto Bolli
Journal: Circulation (2009)

The mouse has become the most commonly used model for assessing the response of the heart to ischemic injury. However, the confounding influences of genetic strain, gender, age, body temperature, a...
Problems in Tuberculosis. Administration: Diagnosis: Employment: Settlements.
Authors: Fowler, James Kingston, Sir
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal