tbuckley/cabot-search huggingface dataset:
Management of Foreign Bodies in the Gastrointestinal Tract: An Analysis of 104 Cases in Children
Authors: None Kim, None Kim, None Kim, None Kim, None Yang, None Cho, None Lee, None Han, None Han, None Chung, None Chung, None Sun
Journal: Endoscopy (1999)

Background and Study Aims: Ingested foreign bodies may be managed by endoscopy, observation, or surgery. The aim of the study was to investigate the methods of removal of foreign bodies according to type and location, success rates, and complications.
Preventing injuries in children
Authors: E. Waters, P. Priest, C. Foster, A. Andermann, D. Kendrick, P. Marsh, K. Fielding, P. Miller
Journal: BMJ (1999)

# Elements of trial's design and analysis might have biased results {#article-title-2} EDITOR—We overwhelmingly believe that trials should be carried out in primary care to assess child health promotion. Kendrick et al report the lack of effectiveness of a package of health injury prevention strategies delivered by health visitors.1 Before this lack of effectiveness is accepted, we recommend critical analysis of elements of the design and analysis of the trial that might bias results towards the null hypothesis. Further information is needed to enable the generalisability of interventions to be assessed. Factors possibly leading to bias
Abstract 407: Stress Myocardial Perfusion Imaging by Cardiac Magnetic Resonance Provides Accurate Detection of Coronary Artery Disease and Strong Prognostic Value to Hard Cardiac Events Regardless of Patient's Gender
Authors: Otavio R Coelho-Filho, Luciana F Seabra, Shuaib M Abdullah, David A Carballo, Sanjeev A Francis, Sanjay Gupta, Ron Blankstein, Michael Jerosch-Herold, Raymond Y Kwong
Journal: Circulation (2009)

Background Noninvasive detection of CAD in women is often limited by soft tissue attenuation and limits in spatial resolution. CMR perfusion imaging (CMRPI) may characterize evidence of flow limiti...
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
Authors: Xinli Hu, Aaron J Deutsch, Tobias L Lenz, Suna Onengut-Gumuscu, Buhm Han, Wei-Min Chen, Joanna M M Howson, John A Todd, Paul I W de Bakker, Stephen S Rich, Soumya Raychaudhuri
Journal: Nature Genetics (2015)
Abstract 12105: Chronic Bendavia (a Mitochondrial-Targeting Peptide) Restores Mitochondrial Related Gene Expression in the Noninfarcted Border Zone of Infarcted Hearts
Authors: Jianru Shi, Wangde Dai, Sharon L Hale, Robert A Kloner
Journal: Circulation (2013)

Background: Mitochondrial dysfunction has been implicated in post-infarction heart failure. Bendavia, a mitochondrial-targeting peptide, protects mitochondrial function by enhancing bioenergetics u...
The Utility of Therapeutic Hypothermia for Post–Cardiac Arrest Syndrome Patients With an Initial Nonshockable Rhythm
Authors: Sarah M. Perman, Anne V. Grossestreuer, Douglas J. Wiebe, Brendan G. Carr, Benjamin S. Abella, David F. Gaieski
Journal: Circulation (2015)

Background— Therapeutic hypothermia (TH) attenuates reperfusion injury in comatose survivors of cardiac arrest. The utility of TH in patients with nonshockable initial rhythms has not been widely accepted. We sought to determine whether TH improved neurological outcome and survival in postarrest patients with nonshockable rhythms. Methods and Results— We identified 519 patients after in- and out-of-hospital cardiac arrest with nonshockable initial rhythms from the Penn Alliance for Therapeutic Hypothermia (PATH) registry between 2000 and 2013. Propensity score matching was used. Patient and arrest characteristics used to estimate the propensity to receive TH were age, sex, location of arrest, witnessed arrest, and duration of arrest. To determine the association between TH and outcomes, we created 2 multivariable logistic models controlling for confounders. Of 201 propensity score–matched pairs, mean age was 63±17 years, 51% were male, and 60% had an initial rhythm of pulseless electric activity. Survival to hospital discharge was greater in patients who received TH (17.6% versus 28.9%; P &lt;0.01), as was a discharge Cerebral Performance Category of 1 to 2 (13.7% versus 21.4%; P =0.04). In adjusted analyses, patients who received TH were more likely to survive (odds ratio, 2.8; 95% confidence interval, 1.6–4.7) and to have better neurological outcome (odds ratio, 3.5; 95% confidence interval, 1.8–6.6) than those that did not receive TH. Conclusions— Using propensity score matching, we found that patients with nonshockable initial rhythms treated with TH had better survival and neurological outcome at hospital discharge than those who did not receive TH. Our findings further support the use of TH in patients with initial nonshockable arrest rhythms.
Abstract 13900: Impact of Paravalvular Leak
Authors: Sandro Sponga, Jean Perron, Francois Dagenais, Siamak Mohammadi, Richard Baillot, Daniel Doyle, Pierre Voisine
Journal: Circulation (2011)

OBJECTIVE Mild to moderate aortic regurgitation (AR) is not infrequently encountered after standard aortic valve replacement, and reportedly more often following transcatheter aortic valve implanta...
Abstract 16130: Right Ventricular Dysfunction After Acute Myocardial Infarction in the Absence of Pulmonary Hypertension
Authors: Benjamin W Van Tassell, Hem L Bhardwaj, Herman J Bogaard, John D Grizzard, Michael C Kontos, Stefano Toldo, Eleonora Mezzaroma, George W Vetrovec, Norbert F Voelkel, Antonio Abbate
Journal: Circulation (2011)

Background. Cardiac remodelling after AMI is characterized by molecular and cellular mechanisms involving both the ischemic and non-ischemic myocardium. The extent of right ventricular (RV) dilatat...
TP53 mutations in de novo acute myeloid leukemia patients: longitudinal follow-ups show the mutation is stable during disease evolution
Authors: H-A Hou, W-C Chou, Y-Y Kuo, C-Y Liu, L-I Lin, M-H Tseng, Y-C Chiang, M-C Liu, C-W Liu, J-L Tang, M Yao, C-C Li, S-Y Huang, B-S Ko, S-C Hsu, C-Y Chen, C-T Lin, S-J Wu, W Tsay, Y-C Chen, H-F Tien
Journal: Blood Cancer Journal (2015)

Abstract The TP53 mutation is frequently detected in acute myeloid leukemia (AML) patients with complex karyotype (CK), but the stability of this mutation during the clinical course remains unclear. In this study, TP53 mutations were identified in 7% of 500 patients with de novo AML and 58.8% of patients with CK. TP53 mutations were closely associated with older age, lower white blood cell (WBC) and platelet counts, FAB M6 subtype, unfavorable-risk cytogenetics and CK, but negatively associated with NPM1 mutation, FLT3/ ITD and DNMT3A mutation. Multivariate analysis demonstrated that TP53 mutation was an independent poor prognostic factor for overall survival and disease-free survival among the total cohort and the subgroup of patients with CK. A scoring system incorporating TP53 mutation and nine other prognostic factors, including age, WBC counts, cytogenetics and gene mutations, into survival analysis proved to be very useful to stratify AML patients. Sequential study of 420 samples showed that TP53 mutations were stable during AML evolution, whereas the mutation was acquired only in 1 of the 126 TP53 wild-type patients when therapy-related AML originated from different clone emerged. In conclusion, TP53 mutations are associated with distinct clinic-biological features and poor prognosis in de novo AML patients and are rather stable during disease progression.
Abstract 2632: Stroke Protection Is Largely Related To Cholesterol-lowering In Lipid-lowering Intervention Trials: A Meta-analysis And Meta-regression
Authors: Raffaele De Caterina, Marco Scarano, Francesco Palma, Rosamaria Marfisi, Pericle Di Napoli, Giovanna Borrelli, Roberto Marchioli
Journal: Circulation (2008)

Background: In clinical trials, statins reduce the incidence of strokes. It has been proposed that such effect is independent of cholesterol lowering and best explained by alternative mechanisms. We tested whether the effects of statins on stroke is qualitatively similar to that of other cholesterol-lowering interventions, and explained by cholesterol lowering. Methods: We reviewed the literature of randomized lipid-lowering trials reporting the stroke incidence, for a total of 176,974 patients investigated and a cumulative 627,117 patients/year exposure. Strokes incidence was related to treatments tested in the trials, and a meta-regression related the extent of stroke reduction as a function of the reduction in total cholesterol. Results: The odds ratio and 95% confidence interval (95% CI) for the total incidence of stroke in the actively-treated group compared with controls were 0.86 (0.81– 0.91, p&lt;0.001). Statins decreased the risk of total stroke significantly (0.83, 0.78 – 0.89, p&lt;0.001). The benefit of non-statin interventions on total stroke was small and not statistically significant (OR 0.95, 95% CI 0.85–1.08, p=N.S.). In the meta-regression, however, we found a significant relationship between the percent reduction of total cholesterol obtained in both statin and non-statin trials and the percent reduction of the relative risk of total stroke (p=0.0471). Neither statins nor other cholesterol-lowering interventions reduced the risk of fatal stroke. Conclusions: Among lipid-lowering interventions, statins are effective in decreasing the risk of total stroke, but their benefit appears associated with the extent of reduction of blood cholesterol, and is in line with their greater cholesterol-lowering potency compared with non-statin interventions.
Abstract 2439: Invasive Right Ventricular Hemodynamics and Tricuspid Annular Plane Systolic Excursion to Predict Right Ventricular Dysfunction After Left Ventricular Assist Device Implantation
Authors: Elizabeth A Ketner, Paul R Forfia, Stuart R Russell, Ilan S Wittstein, John V Conte, Ashish Shah, David Yuh, Hunter C Champion
Journal: Circulation (2008)

Introduction : Right ventricular (RV) failure is a major cause of morbidity and mortality in heart failure patients undergoing destination left ventricular assist device (LVAD) implantation. Using tricuspid annular plane systolic excursion (TAPSE; an echo based measure of RV function linked to mortality in patients with pulmonary arterial hypertension) and invasive measurement of RV systolic function (dP/dtmax/IP; dP/dt max normalized to instantaneous pressure) we hypothesized that these parameters correlate with the incidence of RV failure post LVAD implantation. Methods : 65 consecutive patients with heart failure and clinical indication for LVAD implantation were prospectively evaluated. All patients underwent transthoracic echocardiography and right heart catheterization within 14 days prior to implantation. TAPSE was measured by M-mode echocardiography as the mean displacement (cm) of the tricuspid annular plane towards the RV apex from end-diastole to end-systole over 3 to 5 cycles. RVFAC was measured as the percent change in RV area from end diastole to end systole as measured in the apical four chamber view. Pressure-dependent measures of RV function were derived from PA catheterization based RV waveforms analyzed using pressure volume loop software (WinPVAN 3.5.8). RV failure post LVAD was defined as IV inotrope therapy requirement &gt;14 days, inhaled NO use &gt;48 hrs, death due to decompensated RV failure, or RVAD implantation. Clinical, hemodynamic and echo data were compared in patients with RV Failure (group I; n=14) vs. those without RV failure (group II; n=51). Results : Groups I and II had similar mean pulmonary arterial pressure, cardiac index, systolic blood pressure, baseline liver function test values, and renal function (P&gt;0.05). Group I had higher right atrial pressure (14±5vs.11±4 mmHg; *p&lt;0.05). TAPSE of less than 1.8 cm and dP/dt max /IP of less than 10 correlated strongly with RV failure post LVAD implantation (P&lt;0.005 and P&lt;0.001, respectively) while RVFAC showed no correlation. Conclusions : TAPSE and the load-independent index dP/dt max/IP correlate strongly with RV failure post-LVAD implantation. These data provide the basis for future study of these endpoints in patients with heart failure and RV dysfunction.
Abstract 5862: Development of Systolic Dysfunction Not Related to Myocardial Infarction in Treated Hypertensive Patients With Left Ventricular Hypertrophy: The LIFE Echo Substudy
Authors: Marcello Chinali, Gerard P Aurigemma, Peter M Okin, Eva Gerdts, Kristian Wachtell, Sverre E Kjeldsen, Stevo Julius, Bjorn Dahlof, Giovanni de Simone, Richard B Devereux
Journal: Circulation (2009)
尿频、尿急、尿痛并非都是尿路感染
Authors: 蒲冶青
Journal: BMJ (2008)

在日常工作中我经常遇到因尿频、尿急、尿痛而就诊的女性患者.检查多有膀胱区压痛,尿中白细胞.通常是按尿路感染给予抗炎治疗.但有些患者反复出现上述症状,开始时用抗生素治疗还有效,时间一长就不起作用了.通过详细了解病史,我发现引起上述症状反复发作的原因是多方面的,除了细菌感染外,还有解剖及内分泌改变的影响,与患者的年龄和卫生习惯也有关系。
Abstract 21313: A Proposed Innovative Approach to Compute Individual Carotid Intima-Media Thickness Progression
Authors: Fabrizio Veglia, Damiano Baldassarre, Mauro Amato, Alessio Ravani, Daniela Sansaro, Calogero C Tedesco, Andrea Discacciati, Beatrice Frigerio, Samuela Castelnuovo, Elena Tremoli
Journal: Circulation (2010)

Background: Carotid intima media thickness (IMT) progression is more inconsistently associated with vascular risk factors (VRFs) than cross-sectional measurements of carotid IMT. We propose here a new approach to compute IMT progression, which performs much better than progression variables used so far. Methods: This new approach is based on the computation of the “fastest IMT progression”, defined as the fastest IMT increase occurring in the whole carotid tree over a definite time period, regardless of its location. The dataset of the IMPROVE study (3703 subjects) was analyzed to investigate how the “fastest IMT progression” associates with a list of 28 VRFs, as compared to three conventional progression variables, i.e. progression of maximal IMT of the whole carotid tree, progression of mean IMT of the whole carotid tree, and progression of mean IMT of common carotid. Results: Using a P-value cut-off of 0.01, the “fastest IMT progression” showed a significant univariate correlation with 20 out of the 28...