CONCEPTION AND PREGNANCY IN A PATIENT WITH CHRONIC MYELOCYTIC LEUKEMIA UNDER CONTINUOUS COLCEMIDE THERAPY
Authors: E M LESSMANN, J E SOKAL
Journal: Annals of Internal Medicine (1959)

Case Reports1 June 1959CONCEPTION AND PREGNANCY IN A PATIENT WITH CHRONIC MYELOCYTIC LEUKEMIA UNDER CONTINUOUS COLCEMIDE THERAPYELLEN M. LESSMANN, JOSEPH E. SOKALELLEN M. LESSMANNSearch for more papers by this author, JOSEPH E. SOKALSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-6-1512 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of pregnancy and leukemia is rare.1, 2 There has been much interest in this subject, and several comprehensive reviews have been published.3, 4, 5 The dangers of x-ray irradiation therapy in pregnant women have been well documented.6, 7 However, very little information is available on the effects of antileukemic chemotherapy on the course of pregnancy and on the fetus. This report deals with a patient who conceived, had an uneventful pregnancy, and was delivered of a normal infant while under continuous therapy with the antimitotic agent, Colcemide.†Colcemide (also known as Demecolcin), an alkaloid closely related to colchicine,...Bibliography1. McGoldrickLapp JLWA: Leukemia and pregnancy, Am. J. Obst. and Gynec. 46: 711-718, 1943. CrossrefGoogle Scholar2. Gillim DL: Leukemia and pregnancy, Am. J. Obst. and Gynec. 70: 1047-1056, 1955. CrossrefMedlineGoogle Scholar3. Erf HA: Leukemia (summary of 100 cases) and lymphosarcoma complicated by pregnancy, Am. J. Clin. Path. 17: 268-280, 1947. CrossrefMedlineGoogle Scholar4. Harris LJ: Leukemia and pregnancy, Canad. M. A. J. 68: 234-236, 1953. MedlineGoogle Scholar5. NewsonBruceTablerStrother AACHJWWK: Leukemia and pregnancy, Am. J. Obst. and Gynec. 69: 892-894, 1955. CrossrefMedlineGoogle Scholar6. Rolleston H: Harmful effects of irradiation, Quart. J. Med. 24: 101-131, 1930. CrossrefGoogle Scholar7. 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CrossrefMedlineGoogle Scholar21. MerskyRigal CW: Pregnancy in acute leukemia treated with 6 M-P, Lancet 2: 1268-1269, 1956. CrossrefGoogle Scholar22. Zizumi HM: Myleran in pregnancy. Report of a case, J. A. M. A. 161: 969, 1956. CrossrefMedlineGoogle Scholar23. LessmannSokal EMJE: Colcemide in the treatment of chronic myelogenous leukemia, Roswell Park Mem. Inst. Bull. 2: 129-142, 1957. Google Scholar24. BockGross HER: Leukaemie- und Tumorbehandlung mit einem Nebenalkaloid aus Colchicum autumnale (Demecolcin), Acta haemat. 11: 281-300, 1954. CrossrefGoogle Scholar25. Lichtman A: The effect of Demecolcin on the peripheral blood and bone marrow in the rabbit and cat, Thesis, Zurich, 1954. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Buffalo, N. Y.*Received for publication March 22, 1958.From the Division of Medicine, Roswell Park Memorial Institute, Buffalo, N. Y.Requests for reprints should be addressed to Ellen M. Lessmann, M.D., Roswell Park Memorial Institute, Buffalo 3, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPregnancy and concurrent chronic myelogenous leukemiaCOLCHICINE AND CHROMOSOME ABERRATIONSPRACTICAL AND THEORETICAL IMPLICATIONS OF FETAL/MATERNAL LYMPHOCYTE TRANSFERCYTOTOXIC DRUGS IN PREGNANCY. Review of Reported CasesCompounds Interfering with Ovum Implantation and Development 1 June 1959Volume 50, Issue 6Page: 1512-1518KeywordsAlkaloidsBirthChemotherapyChronic myelocytic leukemiaColchicineFetusesInfantsPregnancy ePublished: 1 December 2008 Issue Published: 1 June 1959 PDF downloadLoading ...