tbuckley/cabot-search huggingface dataset:
CLO25-072: A Multicenter, Randomized, Controlled, Non-Inferiority Study of Narlumosbart Compared With Denosumab in the Treatment of Bone Disease in Patients With Multiple Myeloma
Authors: Honghui Huang, Fei Li, Yan Xu, Wenming Chen, Guangxun Gao, Zhongjun Xia, Xiaobing Huang, Jun Luo, Xiaoling Guo, Chunrui Li, Chunyan Sun, Baijun Fang, Fengyan Jin, Yongqian Jia, Shuhao Mei, Juan Du, Rong Zhan, Zhen Cai, Luqun Wang, Hongming Huang, Hongfeng Ge, Xiuhua Han, Jian Hou
Journal: Journal of the National Comprehensive Cancer Network (2025)

"CLO25-072: A Multicenter, Randomized, Controlled, Non-Inferiority Study of Narlumosbart Compared With Denosumab in the Treatment of Bone Disease in Patients With Multiple Myeloma" published on 28 Mar 2025 by National Comprehensive Cancer Network.
CRE25-050: Durable Response to Immunotherapy Rechallenge With Double Immunotherapy for a Patient With Advanced Non-Small Cell Lung Cancer
Authors: Jason T. Huynh, Rui Li, Daniel S. Shin
Journal: Journal of the National Comprehensive Cancer Network (2025)

"CRE25-050: Durable Response to Immunotherapy Rechallenge With Double Immunotherapy for a Patient With Advanced Non-Small Cell Lung Cancer" published on 28 Mar 2025 by National Comprehensive Cancer Network.
CLO25-078: Deciphering Risk of Early Biochemical Recurrence in Prostate Cancer Prior to Definitive Therapy
Authors: Purvish Trivedi, Shivanshu Awasthi, Jasreman Dhillon, Jong Park, Elai Davicioni, Alexander Hakansson, Seagle Liu, Esther Katende, Riley Smith, Kenneth Gage, Ryan Burri, Cesar Ercole, Julio Pow-Sang, Kosj Yamoah
Journal: Journal of the National Comprehensive Cancer Network (2025)
A stress-dependent TDP-43 SUMOylation program preserves neuronal function
Authors: Terry R. Suk, Caroline E. Part, Jenny L. Zhang, Trina T. Nguyen, Meghan M. Heer, Alejandro Caballero-Gómez, Veronica S. Grybas, Paul M. McKeever, Benjamin Nguyen, Tahir Ali, Steve M. Callaghan, John M. Woulfe, Janice Robertson, Maxime W. C. Rousseaux
Journal: Molecular Neurodegeneration (2025)

Abstract Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are overwhelmingly linked to TDP-43 dysfunction. Mutations in TDP-43 are rare, indicating that the progressive accumulation of exogenous factors – such as cellular stressors – converge on TDP-43 to play a key role in disease pathogenesis. Post translational modifications such as SUMOylation play essential roles in response to such exogenous stressors. We therefore set out to understand how SUMOylation may regulate TDP-43 in health and disease. We find that TDP-43 is regulated dynamically via SUMOylation in response to cellular stressors. When this process is blocked in vivo, we note age-dependent TDP-43 pathology and sex-specific behavioral deficits linking TDP-43 SUMOylation with aging and disease. We further find that SUMOylation is correlated with human aging and disease states. Collectively, this work presents TDP-43 SUMOylation as an early physiological response to cellular stress, disruption of which may confer a risk for TDP-43 proteinopathy.
Achilles tendinopathy
Authors: Andreas Traweger, Alex Scott, Michael Kjaer, Evi Wezenbeek, Rodrigo Scattone Silva, John G. Kennedy, James J. Butler, Manuel Gomez-Florit, Manuela E. Gomes, Jess G. Snedeker, Stephanie G. Dakin, Britt Wildemann
Journal: Nature Reviews Disease Primers (2025)
CLO25-064: Development and Validation of a Prediction Model for Acute Kidney Injury Following Hyperthermic Intraperitoneal Chemotherapy in Patients With Ovarian Cancer
Authors: Lai Yuting, Yanan Lu, Dan Xie, Hui Li, Dongyan Wang, Yichun Xing, Miaofang Wu, Jing Li
Journal: Journal of the National Comprehensive Cancer Network (2025)

"CLO25-064: Development and Validation of a Prediction Model for Acute Kidney Injury Following Hyperthermic Intraperitoneal Chemotherapy in Patients With Ovarian Cancer" published on 28 Mar 2025 by National Comprehensive Cancer Network.
CLO25-070: Effects and Mechanisms of CD16+/-NK Cells on Ovarian Malignant Tumor Cells Platinum-Based Drug Responsiveness in Tumor Microenvironment
Authors: Feifei Song, Xiaodong Cheng
Journal: Journal of the National Comprehensive Cancer Network (2025)

"CLO25-070: Effects and Mechanisms of CD16+/-NK Cells on Ovarian Malignant Tumor Cells Platinum-Based Drug Responsiveness in Tumor Microenvironment" published on 28 Mar 2025 by National Comprehensive Cancer Network.
CLO25-102: Survival Outcomes in Breast Cancer Patients With Diseased Axillary Lymph Nodes: The Role of Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy.
Authors: Marwa Youssef, Suaad AlAghbari, Hasan Al-Sayegh, Khalid Albaimani, Badriya AlQassabi, Adil AlAjmi
Journal: Journal of the National Comprehensive Cancer Network (2025)

"CLO25-102: Survival Outcomes in Breast Cancer Patients With Diseased Axillary Lymph Nodes: The Role of Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy." published on 28 Mar 2025 by National Comprehensive Cancer Network.
CLO25-069: Single Dose Nivolumab and Ipilimumab Treatment Causing Complete and Durable Response in Extensive Stage Small Cell Lung Cancer Complicated By Severe Sensory Autoimmune Neuropathy
Authors: Aaron Charles Lobo, Nur Rahman, Nicholas Blondin, Neal Fischbach
Journal: Journal of the National Comprehensive Cancer Network (2025)

"CLO25-069: Single Dose Nivolumab and Ipilimumab Treatment Causing Complete and Durable Response in Extensive Stage Small Cell Lung Cancer Complicated By Severe Sensory Autoimmune Neuropathy" published on 28 Mar 2025 by National Comprehensive Cancer Network.
CLO25-080: Outcomes of Extreme Low PD-L1 Expression in Advanced Non-Small Cell Lung Cancer: Implications for Treatment Approaches
Authors: Alexander Rudich, Natalie Johns, Songzhu Zhao, Kenneth Chian, Po-Lan Su, Adam Khorasanchi, Jinesh Gheeya, Daniel Spakowicz, Lai Wei, Logan Roof, Asrar Alahmadi, Regan Memmott, Jacob Kaufman, Carolyn Presley, Kai He, Peter Shields, Christian Rolfo, David Carbone, Mingjia Li, Dwight Owen
Journal: Journal of the National Comprehensive Cancer Network (2025)
CLO25-076: CD13 as a Potential Membrane Marker in PSMA-Negative Prostate Cancer and First-in-Human Study of [18F]AlF-CD13-L1 PET/CT Imaging
Authors: Wei Tang, Ming Zhou, Chenxi Lu, Lin Qi, Ye Zhang, Yongxiang Tang, Xiaomei Gao, Shuo Hu, Yi Cai
Journal: Journal of the National Comprehensive Cancer Network (2025)

"CLO25-076: CD13 as a Potential Membrane Marker in PSMA-Negative Prostate Cancer and First-in-Human Study of [18F]AlF-CD13-L1 PET/CT Imaging" published on 28 Mar 2025 by National Comprehensive Cancer Network.
CLO25-074: Outcomes to Immune Checkpoint Inhibitors (ICIs) According to Programmed Death-Ligand 1 (PD-L1) Levels in KRAS-, KEAP1-, STK11-Mutant Lung Squamous Cell Carcinoma (LSCC)
Authors: Justin W. Shi, Ahmad Karkash, Weston He, Mya T. Tran, Yan Han, Misty Dawn Shields, Julian A. Marin-Acevedo
Journal: Journal of the National Comprehensive Cancer Network (2025)

"CLO25-074: Outcomes to Immune Checkpoint Inhibitors (ICIs) According to Programmed Death-Ligand 1 (PD-L1) Levels in KRAS-, KEAP1-, STK11-Mutant Lung Squamous Cell Carcinoma (LSCC)" published on 28 Mar 2025 by National Comprehensive Cancer Network.
CLO25-066: Prognostic Role of Pre-Transplant EASIX on Non-Relapse Mortality and Overall Survival in Allogeneic Stem Cell Transplantation: A Meta-Analysis
Authors: Diksha Sanjana Pasnoor, Rishabh Arun Vashisht, Mohit Mirchandani, Nency Ganatra, Beenish Najam, Akhil Jain, Rupak Desai
Journal: Journal of the National Comprehensive Cancer Network (2025)

"CLO25-066: Prognostic Role of Pre-Transplant EASIX on Non-Relapse Mortality and Overall Survival in Allogeneic Stem Cell Transplantation: A Meta-Analysis" published on 28 Mar 2025 by National Comprehensive Cancer Network.
QIM25-222: Evaluating Implementation of Advanced Provider Driven Comprehensive Management Program to Support Patients With Immune-Oncology Toxicity
Authors: Anamika Chaudhuri, Julia S. Pimkina
Journal: Journal of the National Comprehensive Cancer Network (2025)

"QIM25-222: Evaluating Implementation of Advanced Provider Driven Comprehensive Management Program to Support Patients With Immune-Oncology Toxicity" published on 28 Mar 2025 by National Comprehensive Cancer Network.
HSR25-198: A Systematic Review and Meta-Analysis of Randomized Controlled Trials to Evaluate the Incidence of Hand-Foot Skin Reaction (HFSR) or Palmar-Plantar Erythrodysesthesia (PPE) in Patients With Cancers Treated With Fruquintinib
Authors: Jason Ta, Benjamin Tzer-Ming Chuang, Hazem Aboaid, Daniel Thomas Jones, Ramaditya Srinivasmurthy, Kevin Nguyen, Rishi Kumar Nanda, Yin Mon Myat, Kyaw Zin Thein
Journal: Journal of the National Comprehensive Cancer Network (2025)

"HSR25-198: A Systematic Review and Meta-Analysis of Randomized Controlled Trials to Evaluate the Incidence of Hand-Foot Skin Reaction (HFSR) or Palmar-Plantar Erythrodysesthesia (PPE) in Patients With Cancers Treated With Fruquintinib" published on 28 Mar 2025 by National Comprehensive Cancer Network.
EPR25-117: Cardiovascular Events in Patients Diagnosed With Light Chain Amyloidosis in the USA: A Real-World Analysis Utilizing Electronic Health Records
Authors: Pedro A. Laires, Shona Fang, Jennifer Evans, Jeffrey Thompson, Abhishek Gaur, Brendon Staruk, Ankita Gupta, Richa Manwani
Journal: Journal of the National Comprehensive Cancer Network (2025)

"EPR25-117: Cardiovascular Events in Patients Diagnosed With Light Chain Amyloidosis in the USA: A Real-World Analysis Utilizing Electronic Health Records" published on 28 Mar 2025 by National Comprehensive Cancer Network.
CLO25-091: Impact of PD-L1 Expression on Immune-Related Adverse Events (irAEs) in Non-Small Cell Lung Cancer (NSCLC): Real-World Data From Community Oncology Practice
Authors: Tejas Karawadia, Hardik Chhatrala, Avani Shah, Audrey Bui, Min Chae, Bijoy Telivala
Journal: Journal of the National Comprehensive Cancer Network (2025)

"CLO25-091: Impact of PD-L1 Expression on Immune-Related Adverse Events (irAEs) in Non-Small Cell Lung Cancer (NSCLC): Real-World Data From Community Oncology Practice" published on 28 Mar 2025 by National Comprehensive Cancer Network.
HPV Vaccine Cuts Cervical Precancer Incidence, but Rural Access Gaps Remain
Authors: Samantha Anderer
Journal: JAMA (2025)

Trisha L. Amboree, PhD, MPH; Haluk Damgacioglu, PhD; Elizabeth Y. Chiao, MD; Kathleen M. Schmeler, MD; Kalyani Sonawane, PhD; Ashish A. Deshmukh, PhD; Jane R. Montealegre, PhD
CLO25-093: Surgical Timing and Its Effect on Disease Progression in Non-Small Cell Lung Cancer: A Stage-Specific Analysis
Authors: Ahmed Fahmy Mandisha, Stamatina Koskolou, Mohammad Ibrahim, Kamran Inamdar, Md Kamrul Hasan, Joshua Samuel, Anfal Farah, Abdelhadi Isamil, Musab Mohammed, Tom Combellack, Malgorzata Kornaszewska, Ainis Pirtnieks, Vasilios Valtzoglou
Journal: Journal of the National Comprehensive Cancer Network (2025)
QIM25-224: Demonstrating Value of a Shared Management Approach in the Care of Surgical Oncology Patients at an Academic Cancer Center
Authors: Misbahuddin Syed, Reurita Deam, Timothy Hembree
Journal: Journal of the National Comprehensive Cancer Network (2025)

"QIM25-224: Demonstrating Value of a Shared Management Approach in the Care of Surgical Oncology Patients at an Academic Cancer Center" published on 28 Mar 2025 by National Comprehensive Cancer Network.
US Hospital Bed Shortage Looms as Occupancy Rates Climb
Authors: Samantha Anderer
Journal: JAMA (2025)

Richard K. Leuchter, MD; Benjo A. Delarmente, MD, PhD, MPP; Sitaram Vangala, MS; Yusuke Tsugawa, MD, PhD, MPH; Catherine A. Sarkisian, MD, MSHS
EPR25-140: Socioeconomic and Clinical Determinants of Survival in Young Breast Cancer Patients: A Population Based Study
Authors: Charmi Bhanushali, Sharanya Tripathi, Kalaivani Babu, Srinishant Rajarajan, Jayalekshmi Jayakumar, Vidhi Bhanushali, Arya Mariam Roy
Journal: Journal of the National Comprehensive Cancer Network (2025)
EPR25-138: Glioblastoma Multiforme: A SEER STAT Analysis of Epidemiological, Laterality, and Anatomical Prognostic Indicators
Authors: Jaison Lawrence Alexander Santhi, Hassan Ali, Charan Thej Reddy Vegivinti, Elizaveta Bodrova, Mansi Mehta, Reema Sara Varghese, Varsha Sriram, Rajesh Thirumaran
Journal: Journal of the National Comprehensive Cancer Network (2025)
EPR25-127: The Changing Landscape of Venous Thromboembolism in Breast Cancer: Trends Over the Years 2016-2020
Authors: Jayalekshmi Jayakumar, Manasa Ginjupalli, Fiqe Khan, Davin Turku, Surbhi Singh, Arya Mariam Roy
Journal: Journal of the National Comprehensive Cancer Network (2025)
HSR25-146: How Mental Health and Substance Use Drive Cancer Disparities in Urban Communities
Authors: Eunhee Choi, Rama Nada, Abdullah Salahie, Ho Yin Henry Chan, Ruth Benites Llerena, Alejandrina Cuello Ramirez, Maria Albuja Altemirano, Krishna Kishore Anne, Lucia Boettner, Ani Gvajaia, Michael Imeh, Gabriela Galicia Garcia, Monika Ramzy, Saad Alam, Melissa Begolli, Monica Reddy Muppidi, Vidya Menon
Journal: Journal of the National Comprehensive Cancer Network (2025)
HSR25-143: Meta-Analysis of Phase 3 Randomized Controlled Trials to Evaluate the Incidence of Systemic Toxicities in Patients With Relapsed/Refractory Multiple Myeloma Treated With Belantamab Mafodotin
Authors: Riccesha Hattin, Abbas Hussain, Hazem Aboaid, Savannah Schauer, Tal Schlesinger, Rory Twells, Karl Aharonian, Ryan Parto, Rodd Rahmani, Chalette Lambert-Swainston, Daniel Thomas Jones, Ramaditya Srinivasmurthy, Kyaw Zin Thein, Thura Win Htut
Journal: Journal of the National Comprehensive Cancer Network (2025)

"HSR25-143: Meta-Analysis of Phase 3 Randomized Controlled Trials to Evaluate the Incidence of Systemic Toxicities in Patients With Relapsed/Refractory Multiple Myeloma Treated With Belantamab Mafodotin" published on 28 Mar 2025 by National Comprehensive Cancer Network.
Increasing Access to Research Opportunities Among Those Who Speak Languages Other Than English
Authors: Elizabeth A. Jacobs, Monica Vela
Journal: JAMA Network Open (2025)

Henry Hoffman, BA; Tran T. Doan, PhD, MPH; Olivia Migliori, BA; Alisa Khan, MD, MPH; Jaime Sidani, PhD, MPH; Sabrina Liu, MS; Abby Jo Perez, MS; Lani Mears, MBA; Benoit Kihumbu, MS; Khara Timsina, BA; Diego Chaves-Gnecco, MD, MPH; John D. Cowden, MD, MPH; Maya I. Ragavan, MD, MPH, MS
EPR25-132: Hospital-Based Cancer Registry (HBCR) Data Analysis for Women at a Tertiary Care Center in North India
Authors: Kirti Srivastava, Divya Kukreja, Mrinalini Verma, Sumaira Qayoom, Puneet Prakash, Shiv Rajan, Arun Chaturvedi
Journal: Journal of the National Comprehensive Cancer Network (2025)
HSR25-150: Meta-Analysis of Randomized Controlled Trials (RCTs) to Evaluate the Incidence of Health-Related Quality of Life (HRQOL) Events in Patients with Primary Advanced or Recurrent Endometrial Cancer Treated With First-Line Immunochemotherapy
Authors: Daniel Thomas Jones, Hazem Aboaid, Ramaditya Srinivasmurthy, Kevin Nguyen, Jason Ta, Benjamin Tzer-Ming Chuang, Rishi Kumar Nanda, Yin Mon Myat, Kyaw Zin Thein
Journal: Journal of the National Comprehensive Cancer Network (2025)

"HSR25-150: Meta-Analysis of Randomized Controlled Trials (RCTs) to Evaluate the Incidence of Health-Related Quality of Life (HRQOL) Events in Patients with Primary Advanced or Recurrent Endometrial Cancer Treated With First-Line Immunochemotherapy" published on 28 Mar 2025 by National Comprehensive Cancer Network.
TIP25-244: Comprehensive Outcomes for After Cancer Health (COACH) Study: 2024 Trial in Progress Updates
Authors: Kelly Brassil, Barbara Halpenny, Elizabeth Arthur, Maria Chang Swartz, Abbey Kaler, Jessica Krok-Schoen, Robin Lally, Jennifer Loftis, Leorey Saligan, Rachael Schmidt, Angela Starkweather, Alexi Wright, Meagan Whisenant, Sarah Alzahid, Betty Arceneaux, Lauren Ashley Anderson, Jerry Armah, Kristen Fessele, Laura Flora, Alyssa Garcia, Anneliese Gonzalez, Michael Harrison, Kaukab Jafry, Rebecca Johnson-Beller, Ginny Kirklin, Arianna Mohan, Darcy Ponce, Whitney Posada, Elham Samami, Grace Smith, Gisele Tlusty, Martha Thompson, Inga Van Wieren, Gloria Yang, Marilyn Hammer
Journal: Journal of the National Comprehensive Cancer Network (2025)
EPR25-131: Hematologic Adverse Effects Profile of Immune Checkpoint Inhibitors: A Real-World Pharmacovigilance Study Using FAERS Database
Authors: Syed Maaz Tariq, Shafaq Jawed
Journal: Journal of the National Comprehensive Cancer Network (2025)

"EPR25-131: Hematologic Adverse Effects Profile of Immune Checkpoint Inhibitors: A Real-World Pharmacovigilance Study Using FAERS Database" published on 28 Mar 2025 by National Comprehensive Cancer Network.
HSR25-141: Adolescent and Young Adult Cancer Patients: Our Most Financially Vulnerable Demographic
Authors: Brittany C. Kimball, Minji K. Lee, Kimberly O. Steinert, Jordan A. Mason, Wendy A. Hanson, Wendy A. Allen-Rhoades, Allison C. Rosenthal, Robert R. McWilliams
Journal: Journal of the National Comprehensive Cancer Network (2025)
EPR25-125: Therapy-Induced Acute Myeloid Leukemia in Multiple Myeloma Patients: Database Analysis of Risk, Overall Survival and Prognostic Factors
Authors: Nisheem Pokharel, Pravash Budhathoki, Navin Ramlal, Nehemias Guevara-Rodriguez, Elina Shrestha
Journal: Journal of the National Comprehensive Cancer Network (2025)

"EPR25-125: Therapy-Induced Acute Myeloid Leukemia in Multiple Myeloma Patients: Database Analysis of Risk, Overall Survival and Prognostic Factors" published on 28 Mar 2025 by National Comprehensive Cancer Network.
QIM25-223: Acceptability, Facilitators, and Barriers to the Implementation of Screening and Brief Intervention for Alcohol Counseling in the Oncology Setting
Authors: Sydney Freiberg, Noelle LoConte
Journal: Journal of the National Comprehensive Cancer Network (2025)

"QIM25-223: Acceptability, Facilitators, and Barriers to the Implementation of Screening and Brief Intervention for Alcohol Counseling in the Oncology Setting" published on 28 Mar 2025 by National Comprehensive Cancer Network.
HSR25-164: Mapping Patient Reported Side-Effect Incidence to Degradation of Health-Related Quality of Life Dimensions in Lymphoma and Chronic Lymphocytic Leukemia – A Study From the Lymphoma Coalition’s 2024 Global Patient Survey on Lymphomas &amp; CLL
Authors: Steve E. Kalloger, Amanda Watson, Shawn Sajkowski, Natacha Bolaños, Lorna Warwick
Journal: Journal of the National Comprehensive Cancer Network (2025)

"HSR25-164: Mapping Patient Reported Side-Effect Incidence to Degradation of Health-Related Quality of Life Dimensions in Lymphoma and Chronic Lymphocytic Leukemia – A Study From the Lymphoma Coalition's 2024 Global Patient Survey on Lymphomas & CLL" published on 28 Mar 2025 by National Comprehensive Cancer Network.
HSR25-173: Impact of Social Determinants of Health on Lung Cancer Screening and Small Cell Lung Cancer Outcomes in a County Hospital
Authors: Ahmad Karkash, Weston He, Mya Tran, Julian A. Marin-Acevedo, Misty Dawn Shields
Journal: Journal of the National Comprehensive Cancer Network (2025)

"HSR25-173: Impact of Social Determinants of Health on Lung Cancer Screening and Small Cell Lung Cancer Outcomes in a County Hospital" published on 28 Mar 2025 by National Comprehensive Cancer Network.
HSR25-162: Long-term Outcomes in Patients With Tumor Lysis Syndrome and Comorbid Gout: A Propensity-Matched Study From the Global Federated Health Research Network
Authors: Sarah Eidbo, Nanuka Tsibadze, Diego Lema, Justin Lam, Fabian Rodriguez
Journal: Journal of the National Comprehensive Cancer Network (2025)

"HSR25-162: Long-term Outcomes in Patients With Tumor Lysis Syndrome and Comorbid Gout: A Propensity-Matched Study From the Global Federated Health Research Network" published on 28 Mar 2025 by National Comprehensive Cancer Network.
HSR25-177: Impact of the Surin One-Stop Service (S.O.S) System on Reducing Patient Travel and Improving Cancer Treatment Access in Rural Thailand
Authors: Chawalit Chayangsu, Thiya Nusairam, Chalermchai Lertanansit
Journal: Journal of the National Comprehensive Cancer Network (2025)

"HSR25-177: Impact of the Surin One-Stop Service (S.O.S) System on Reducing Patient Travel and Improving Cancer Treatment Access in Rural Thailand" published on 28 Mar 2025 by National Comprehensive Cancer Network.
HSR25-165: The Effectiveness of Implementing a Community-Based Lung Clinic in Rural Community Cancer Center
Authors: Enam A. Alsrayheen, Danial G. French, Alexander Ednie, Aneil Mujoomdar, Madelaine Plourde, Valerie Nugent, Kwamena Beecham, Alison Wallace, Yoana Fuentes, Sarah Gillis, Godson Johnson, Rajbir Pahil
Journal: Journal of the National Comprehensive Cancer Network (2025)
HSR25-157: The Epidemiology and Clinical Outcomes of Lung Cancer Patients With Hypercalcemia: Evidence From a National Inpatient Database.
Authors: Abdu Mohammed, Adamsegd Isac Gebremedhen, Yifang Song, M. Pervaiz Rahman, Kevin Dell, Muhammed Y Jumani, Love Kumar
Journal: Journal of the National Comprehensive Cancer Network (2025)

"HSR25-157: The Epidemiology and Clinical Outcomes of Lung Cancer Patients With Hypercalcemia: Evidence From a National Inpatient Database." published on 28 Mar 2025 by National Comprehensive Cancer Network.
HSR25-181: Assessment of Content Validity of the Functional Assessment of Cancer Therapy – Cutaneous T-Cell Lymphoma (FACT-CTCL)
Authors: Caroline Raymundo, Niloufer Khan, Kevin Molloy, Julia Scarisbrick, Susan Thornton, Rosanne Ottevanger, Cecilia Larocca, Jennifer Chen, David Cella, Michi Shinohara
Journal: Journal of the National Comprehensive Cancer Network (2025)
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence
Authors: Asma Farhat, Mariem Radhouani, Florian Deckert, Sophie Zahalka, Lisabeth Pimenov, Alina Fokina, Anna Hakobyan, Felicitas Oberndorfer, Jessica Brösamlen, Anastasiya Hladik, Karin Lakovits, Fanzhe Meng, Federica Quattrone, Louis Boon, Cornelia Vesely, Philipp Starkl, Nicole Boucheron, Jörg Menche, Joris van der Veeken, Wilfried Ellmeier, Anna-Dorothea Gorki, Clarissa Campbell, Riem Gawish, Sylvia Knapp
Journal: Science Immunology (2025)

Pulmonary fibrosis is an incurable disease that manifests with advanced age. Yet, how hematopoietic aging influences immune responses and fibrosis progression remains unclear. Using heterochronic bone marrow transplant mouse models, we found that an aged bone marrow exacerbates lung fibrosis irrespective of lung tissue age. Upon lung injury, there was an increased accumulation of monocyte-derived alveolar macrophages (Mo-AMs) driven by cell-intrinsic hematopoietic aging. These Mo-AMs exhibited an enhanced profibrotic profile and stalled maturation into a homeostatic, tissue-resident phenotype. This delay was shaped by cell-extrinsic environmental signals such as reduced pulmonary interleukin-10 (IL-10), perpetuating a profibrotic macrophage state. We identified regulatory T cells (T regs ) as critical providers of IL-10 upon lung injury that promote Mo-AM maturation and attenuate fibrosis progression. Our study highlights the impact of an aging bone marrow on lung immune regulation and identifies T reg -mediated IL-10 signaling as a promising target to mitigate fibrosis and promote tissue repair.
HSR25-159: Real-World Effectiveness of First-Line Osimertinib for Patients in the US With Epidermal Growth Factor Receptor-Mutated Advanced Non-Small Cell Lung Cancer Who Were Eligible for Medicare
Authors: Pritesh S. Karia, Yan Kwan Lau, Darren Thomas, Rachel Salomonsen, Rahul Shenolikar
Journal: Journal of the National Comprehensive Cancer Network (2025)

"HSR25-159: Real-World Effectiveness of First-Line Osimertinib for Patients in the US With Epidermal Growth Factor Receptor-Mutated Advanced Non-Small Cell Lung Cancer Who Were Eligible for Medicare" published on 28 Mar 2025 by National Comprehensive Cancer Network.