tbuckley/cabot-search huggingface dataset:
Development and validation of a deep learning radiomics model with clinical-radiological characteristics for the identification of occult peritoneal metastases in patients with pancreatic ductal adenocarcinoma
Authors: Siya Shi, Chuxuan Lin, Jian Zhou, Luyong Wei, Mingjie chen, Jian Zhang, Kangyang Cao, Yaheng Fan, Bingsheng Huang, Yanji Luo, Shi-Ting Feng
Journal: International Journal of Surgery (2024)

Background: Occult peritoneal metastases (OPM) in patients with pancreatic ductal adenocarcinoma (PDAC) are frequently overlooked during imaging. We aimed to develop and validate a CT-based deep learning-based radiomics (DLR) model to identify OPM in PDAC before treatment. Methods: This retrospective, bicentric study included 302 patients with PDAC (training: n=167, OPM-positive, n=22; internal test: n=72, OPM-positive, n=9: external test, n=63, OPM-positive, n=9) who had undergone baseline CT examinations between January 2012 and October 2022. Handcrafted radiomics (HCR) and DLR features of the tumor and HCR features of peritoneum were extracted from CT images. Mutual information and least absolute shrinkage and selection operator algorithms were used for feature selection. A combined model, which incorporated the selected clinical-radiological, HCR, and DLR features, was developed using a logistic regression classifier using data from the training cohort and validated in the test cohorts. Results: Three clinical-radiological characteristics (carcinoembryonic antigen 19-9 and CT-based T and N stages), nine HCR features of the tumor, 14 DLR features of the tumor and three HCR features of the peritoneum were retained after feature selection. The combined model yielded satisfactory predictive performance, with an area under the curve (AUC) of 0.853 (95% confidence interval [CI], 0.790–0.903), 0.845 (95% CI, 0.740–0.919), and 0.852 (95% CI, 0.740–0.929) in the training, internal test, and external test cohorts, respectively (all P &lt;0.05). The combined model showed better discrimination than the clinical-radiological model in the training (AUC=0.853 vs. 0.612, P &lt;0.001) and the total test (AUC=0.842 vs. 0.638, P &lt;0.05) cohorts. The decision curves revealed that the combined model had greater clinical applicability than the clinical-radiological model. Conclusions: The model combining CT-based deep learning radiomics and clinical-radiological features showed satisfactory performance for predicting occult peritoneal metastases in patients with pancreatic ductal adenocarcinoma.
A commentary on ‘transcutaneous electrical acupoint stimulation for preventing postoperative nausea and vomiting after general anesthesia: a meta-analysis of randomized controlled trials’
Authors: Yue Wang, Jianrong Guo, Yong Cheng
Journal: International Journal of Surgery (2024)

Department of Anesthesiology, Shanghai Gongli Hospital, Naval Military Medical University, Shanghai 200135, China All data is available Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: Department of Anesthesiology, Shanghai Gongli Hospital, Naval Military Medical University, Shanghai 200135, China. E-mail address: [email protected] (J. Guo). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
Development of interpretable machine learning models for prediction of acute kidney injury after noncardiac surgery: a retrospective cohort study
Authors: Rao Sun, Shiyong Li, Yuna Wei, Liu Hu, Qiaoqiao Xu, Gaofeng Zhan, Xu Yan, Yuqin He, Yao Wang, Xinhua Li, Ailin Luo, Zhiqiang Zhou
Journal: International Journal of Surgery (2024)

Background: Early identification of patients at high risk of postoperative acute kidney injury (AKI) can facilitate the development of preventive approaches. This study aimed to develop prediction models for postoperative AKI in noncardiac surgery using machine learning algorithms. We also evaluated the predictive performance of models that included only preoperative variables or only important predictors. Materials and methods: Adult patients undergoing noncardiac surgery were retrospectively included in the study (76,457 patients in the discovery cohort and 11,910 patients in the validation cohort). AKI was determined using the KDIGO criteria. The prediction model was developed using 87 variables (56 preoperative variables and 31 intraoperative variables). A variety of machine learning algorithms were employed to develop the model, including logistic regression, random forest, extreme gradient boosting, and gradient boosting decision trees (GBDT). The performance of different models was compared using the area under the receiver operating characteristic curve (AUROC). Shapley Additive Explanations (SHAP) analysis was employed for model interpretation. Results: The patients in the discovery cohort had a median age of 52 years (IQR: 42-61 y), and 1179 patients (1.5%) developed AKI after surgery. The GBDT algorithm showed the best predictive performance using all available variables, or only preoperative variables. The AUROCs were 0.849 (95% CI, 0.835-0.863) and 0.828 (95% CI, 0.813-0.843), respectively. The SHAP analysis showed that age, surgical duration, preoperative serum creatinine and gamma-glutamyltransferase, as well as American Society of Anesthesiologists physical status III were the most important five features. When gradually reducing the features, the AUROCs decreased from 0.852 (including the top 40 features) to 0.839 (including the top 10 features). In the validation cohort, we observed a similar pattern regarding the models’ predictive performance. Conclusions: The machine learning models we developed had satisfactory predictive performance for identifying high-risk postoperative AKI patients. Further, we found that model performance was only slightly affected when only preoperative variables or only the most important predictive features were included.
A commentary on ‘Efficacy and safety of vitamin C for atrial fibrillation after cardiac surgery: a meta-analysis with trial sequential analysis of randomized controlled trials’
Authors: Changzhong Wang, Zijin Sun, Wei Zhou
Journal: International Journal of Surgery (2024)

aGraduate School of Tianjin University of Traditional Chinese Medicine,301600, Tianjin, China bSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 100105, Beijing, China cThe Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, 300000, Tianjin, China #Co-authors:No Co-authors. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, 300000, Tianjin, China. E-mail address: [email protected] (W. Zhou). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Propensity score matching is recommended for retrospective comparative analysis of sarcopenia’s clinical prognostic impact on hepatocellular carcinoma resection patients in Eastern and Western cohorts
Authors: Jia-Xi Mao, Jing-Jing Li, Yuan-Yu Zhao, Han-Xiang Zhong, Xin-Yi Lu, Li-Ye Zhu, Hong Fu, Guo-Shan Ding, Wen-Yuan Guo, Fei Teng
Journal: International Journal of Surgery (2024)

Mao, Jia-Xi MM; Li, Jing-Jing MM; Zhao, Yuan-Yu BMed; Zhong, Han-Xiang MM; Lu, Xin-Yi MM; Zhu, Li-Ye BMed; Fu, Hong MD; Ding, Guo-Shan MD; Guo, Wen-Yuan MD; Teng, Fei MD Author Information
A commentary on ‘Incidence, risk factors, and outcomes of venous thromboembolism in patients undergoing surgery for retroperitoneal tumors: a propensity-matched retrospective cohort study’
Authors: Jiawen Liu, Zheng Jiang, Yefeng Yin
Journal: International Journal of Surgery (2024)

aDepartment of Gastrointestinal,The Ansteel Group Hospital,Anshan,114001,Liaoning,China bDepartment of Colonrectal,Cancer Hospital Chinese Academy of Medical Sciences,Beijing,100000,China Co-authors: Jiawen Liu and Zheng Jiang equally contributed to the article. Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Gastrointestinal, The Ansteel Group Hospital, Anshan, 114001, Liaoning, China. E-mail address: [email protected] (J. Liu). This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0/
Reflections on intraoperative PTH monitoring and frozen biopsy in managing persistent hypercalcemia post-kidney transplant
Authors: Dan Shan
Journal: International Journal of Surgery (2024)

aDepartment of Biobehavioral Sciences, Columbia University, New York, USA bCentre for Ageing Research, Lancaster University, Lancaster, the UK Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Dan Shan, PhD. Centre For Ageing Research, Lancaster University, LA1 4YW, Lancaster, the UK TEL: +353 083-093-5773. E-mail address: [email protected] (D. Shan) This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Envelope protein-specific B cell receptors direct lentiviral vector tropism in vivo
Authors: Kari-Ann Takano, Anita A.L. Wong, Rebecca Brown, Kathy Situ, Bernadette Anne Chua, Angel Elma Abu, Truc T. Pham, Glania Carel Reyes, Sangeetha Ramachandran, Masakazu Kamata, Melody M.H. Li, Ting-Ting Wu, Dinesh S. Rao, Vaithilingaraja Arumugaswami, Kenneth Dorshkind, Steve Cole, Kouki Morizono
Journal: Molecular Therapy (2024)
A commentary on ‘causal effects of gut microbiota on renal tumor: a Mendelian randomization study’ (Int J Surg 2024 Jan 15; Online ahead of print.)
Authors: Junhao Chen, Jieming Zuo, Hongjin Shi, Haifeng Wang, Shi Fu
Journal: International Journal of Surgery (2024)

Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Yunnan, 650106, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article Published online ■ ■ *Corresponding author. Address: Kunming Medical University Second Hospital: Kunming Medical University Second Affliated Hospital, CHINA. E-mail address: [email protected] (S. Fu). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Knowledge mapping of application of image-guided surgery in prostate cancer: a bibliometric analysis (2013–2023)
Authors: Na Zeng, Jian-Xuan Sun, Chen-Qian Liu, Jin-Zhou Xu, Ye An, Meng-Yao Xu, Si-Han Zhang, Xing-Yu Zhong, Si-Yang Ma, Hao-Dong He, Shao-Gang Wang, Qi Dong Xia
Journal: International Journal of Surgery (2024)

Background: Image-guided surgery (IGS) refers to surgery navigated by medical imaging technology, helping doctors better clarify tumor boundaries, identify metastatic lymph nodes and preserve surrounding healthy tissue function. Recent studies have provided expectable momentum of the application of IGS in prostate cancer (PCa). We aim to comprehensively construct a bibliometric analysis of the application of IGS in PCa. Method: We searched publications related to application of IGS in PCa from 2013 to 2023 on the web of science core collection (WoSCC) databases. VOSviewer, CiteSpace and R package “bibliometrix” were used for bibliometric analysis. Results: 2, 389 articles from 75 countries and 2, 883 institutions led by the United States were included. The number of publications related to the application of IGS in PCa kept high in the last decade. Johns Hopkins University is the top research institutions. Journal of Nuclear Medicine has the highest popularity as the selection of journal and co-cited journal. Pomper Martin G. had published the most paper. Ali Afshar-Oromieh was co-cited most frequently. The clinical efficacy of PSMA-PET/CT in PCa diagnosis and treatment are main topics in this research field, with emerging focuses on the use of fluorescence imaging guidance technology in PCa. “PSMA” and “PET/CT” are the main keywords as long-term research hotspots. Conclusion: This study is the first bibliometric analysis of researches on application of IGS in PCa with 3 recognized bibliometric software, providing an objective description and comprehensive guidance for the future relevant investigations.
Site-specific regulation of Th2 differentiation within lymph node microenvironments
Authors: Miranda R. Lyons-Cohen, Elya A. Shamskhou, Michael Y. Gerner
Journal: The Journal of Experimental Medicine (2024)

T helper 2 (Th2) responses protect against pathogens while also driving allergic inflammation, yet how large-scale Th2 responses are generated in tissue context remains unclear. Here, we used quantitative imaging to investigate early Th2 differentiation within lymph nodes (LNs) following cutaneous allergen administration. Contrary to current models, we observed extensive activation and "macro-clustering" of early Th2 cells with migratory type-2 dendritic cells (cDC2s), generating specialized Th2-promoting microenvironments. Macro-clustering was integrin-mediated and promoted localized cytokine exchange among T cells to reinforce differentiation, which contrasted the behavior during Th1 responses. Unexpectedly, formation of Th2 macro-clusters was dependent on the site of skin sensitization. Differences between sites were driven by divergent activation states of migratory cDC2 from different dermal tissues, with enhanced costimulatory molecule expression by cDC2 in Th2-generating LNs promoting prolonged T cell activation, macro-clustering, and cytokine sensing. Thus, the generation of dedicated Th2 priming microenvironments through enhanced costimulatory molecule signaling initiates Th2 responses in vivo and occurs in a skin site-specific manner.
Blood pressure and intensive treatment up‐titration after acute heart failure hospitalization: Insights from the <scp>STRONG‐HF</scp> trial
Authors: Matteo Pagnesi, Oscar Alberto Gomez Vilamajó, Alejandro Meiriño, Carlos Alberto Dumont, Alexandre Mebazaa, Beth Davison, Marianna Adamo, Mattia Arrigo, Marianela Barros, Jan Biegus, Jelena Celutkiene, Kamilė Čerlinskaitė‐Bajorė, Ovidiu Chioncel, Alain Cohen‐Solal, Albertino Damasceno, Rafael Diaz, Christopher Edwards, Gerasimos Filippatos, Etienne Gayat, Antoine Kimmoun, Carolyn S.P. Lam, Maria Novosadova, Peter S. Pang, Piotr Ponikowski, Hadiza Saidu, Karen Sliwa, Koji Takagi, Jozine M. ter Maaten, Daniela Tomasoni, Adriaan A. Voors, Gad Cotter, Marco Metra
Journal: European Journal of Heart Failure (2024)
Clinical outcomes of patients with lymphoid blastic phase of chronic myeloid leukemia treated with CAR T-cell therapy
Authors: Yujie Liu, Yuqing Tu, Jinyan Xiao, Yifan Shen, Biqi Zhou, Qiannan Yang, Lei Yu, Lijuan Qi, Jia Chen, Tianhui Liu, Depei Wu, Yang Xu
Journal: Blood Cancer Journal (2024)
Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing
Authors: Jian-Rong Li, Shahram Arsang-Jang, Yan Cheng, Fumou Sun, Anita D'Souza, Binod Dhakal, Parameswaran Hari, Quillan Huang, Paul Auer, Yong Li, Raul Urrutia, Fenghuang Zhan, John D Shaughnessy, Siegfried Janz, Jing Dong, Chao Cheng
Journal: Blood Cancer Journal (2024)

Abstract Multiple myeloma (MM) is a heterogenous plasma cell malignancy, for which the established prognostic models exhibit limitations in capturing the full spectrum of outcome variability. Leveraging single-cell RNA-sequencing data, we developed a novel plasma cell gene signature. We evaluated and validated the associations of the resulting plasma cell malignancy (PBM) score with disease state, progression and clinical outcomes using data from five independent myeloma studies consisting of 2115 samples (1978 MM, 65 monoclonal gammopathy of undetermined significance, 35 smoldering MM, and 37 healthy controls). Overall, a higher PBM score was significantly associated with a more advanced stage within the spectrum of plasma cell dyscrasias (all p &lt; 0.05) and a shorter overall survival in MM (hazard ratio, HR = 1.72; p &lt; 0.001). Notably, the prognostic effect of the PBM score was independent of the International Staging System (ISS) and Revised ISS (R-ISS). The downstream analysis further linked higher PBM scores with the presence of cytogenetic abnormalities, TP53 mutations, and compositional changes in the myeloma tumor immune microenvironment. Our integrated analyses suggest the PBM score may provide an opportunity for refining risk stratification and guide decisions on therapeutic approaches to MM.
Translating ultrasound-mediated drug delivery technologies for CNS applications
Authors: Ederlyn Perolina, Svenja Meissner, Brad Raos, Bruce Harland, Sachin Thakur, Darren Svirskis
Journal: Advanced Drug Delivery Reviews (2024)

Ultrasound enhances drug delivery into the central nervous system (CNS) by opening barriers between the blood and CNS and by triggering release of drugs from carriers. A key challenge in translating setups from in vitro to in vivo settings is achieving equivalent acoustic energy delivery. Multiple devices have now been demonstrated to focus ultrasound to the brain, with concepts emerging to also target the spinal cord. Clinical trials to date have used ultrasound to facilitate the opening of the blood–brain barrier. While most have focused on feasibility and safety considerations, therapeutic benefits are beginning to emerge. To advance translation of these technologies for CNS applications, researchers should standardise exposure protocol and fine-tune ultrasound parameters. Computational modelling should be increasingly used as a core component to develop both in vitro and in vivo setups for delivering accurate and reproducible ultrasound to the CNS. This field holds promise for transformative advancements in the management and pharmacological treatment of complex and challenging CNS disorders.
Unrelated donor hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for adults with severe aplastic anemia
Authors: Liangliang Wu, Limin Liu, Xin Zhao, Ming Zhou, Andie Fu, Yuping Zhang, Wenrui Yang, Xiaowei Chen, Wenjian Mo, Caixia Wang, Yumiao Li, Shilin Xu, Shiyi Pan, Ruiqing Zhou, Fankai Meng, Fengkui Zhang, Depei Wu, Shunqing Wang
Journal: Blood Cancer Journal (2024)

Unrelated donor hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for
Clinical outcomes and safety of immune checkpoint inhibitors in patients with solid tumors and paraneoplastic syndromes
Authors: Amin H Nassar, Talal El Zarif, Ahmed Bilal Khalid, Serena Rahme, Caiwei Zhong, Lucia Kwak, Marita Salame, Elias Bou Farhat, Dory Freeman, Edward El-Am, Arjun Ravishankar, Bachar Ahmad, Frank Aboubakar Nana, David Kaldas, Abdul Rafeh Naqash, Elad Sharon, Nicole R LeBoeuf, Alessio Cortellini, Andrea Malgeri, Shruti Gupta, Ahmad Al-Hader, Jeffrey A Sparks, Jenny Linnoila, Ole-Petter R Hamnvik, Tarek H Mouhieddine, Thomas Marron, Kaushal Parikh, Rana R McKay, Thomas Dilling, Toni K Choueiri, Elio Adib, Elie Najem, So Yeon Kim, Guru Sonpavde
Journal: Journal for ImmunoTherapy of Cancer (2024)

Background Patients with paraneoplastic syndromes (PNS) are excluded from clinical trials involving immune checkpoint inhibitors (ICIs) due to safety concerns. Moreover, real-world data on efficacy and safety is scarce. Methods In this retrospective study, data were collected on patients with PNS and solid tumors receiving ICI between 2015 and 2022 at nine institutions. Patients were classified into: Cohort 1 (pre-existing PNS before ICI initiation), cohort 2 (PNS during ICI treatment), and cohort 3 (PNS after ICI discontinuation). Patients with metastatic non-small cell lung cancer (NSCLC) (mNSCLC) from cohort 1 were matched to patients who were PNS-free at each institution up to a 1:3 ratio for age, sex, type of ICI, use of concurrent chemotherapy, and number of lines of systemic therapy prior to ICI initiation. Kaplan-Meier method was used to assess overall survival (OS) and time-to-next treatment (TTNT). Results Among 109 patients with PNS treated with ICIs, median age at ICI initiation was 67 years (IQR: 58–74). The most represented cancer type was NSCLC (n=39, 36%). In cohort 1 (n=55), PNS exacerbations occurred in 16 (29%) patients with median time to exacerbation after ICI of 1.1 months (IQR: 0.7–3.3). Exacerbation or de novo PNS prompted temporary/permanent interruption of ICIs in 14 (13%) patients. For cohort 2 (n=16), median time between ICI initiation and de novo PNS was 1.2 months (IQR: 0.4–3.5). Treatment-related adverse events (trAEs) occurred in 43 (39%) patients. Grade ≥3 trAEs occurred in 18 (17%) patients. PNS-directed immunosuppressive therapy was required in 55 (50%) patients. We matched 18 patients with mNSCLC and PNS (cohort 1) to 40 without PNS, treated with ICIs. There was no significant difference in OS or TTNT between patients with mNSCLC with and without PNS, although a trend was seen towards worse outcomes in patients with PNS. TrAEs occurred in 6/18 (33%) and 14/40 (35%), respectively. Grade ≥3 trAEs occurred in 4 (22%) patients with PNS and 7 (18%) patients without PNS. Conclusions Exacerbations of pre-existing PNS occurred in 29% of patients treated with ICIs and both exacerbations and de novo PNS occur early in the ICI course. TrAE from ICIs were similar between patients with and without PNS. Our data suggest that pre-existing PNS should not preclude consideration of ICI therapy although patients may not derive the same clinical benefit compared with patients without PNS.
Highly Sensitive and Fast Responding Flexible Force Sensors Using ZnO/ZnMgO Coaxial Nanotubes on Graphene Layers for Breath Sensing
Authors: Asad Ali, Jamin Lee, Kyoungho Kim, Hongseok Oh, Gyu‐Chul Yi
Journal: Advanced Healthcare Materials (2024)

Abstract The authors report the fabrication of highly sensitive, rapidly responding flexible force sensors using ZnO/ZnMgO coaxial nanotubes grown on graphene layers and their applications in sleep apnea monitoring. Flexible force sensors are fabricated by forming Schottky contacts to the nanotube array, followed by the mechanical release of the entire structure from the host substrate. The electrical characteristics of ZnO and ZnO/ZnMgO nanotube‐based sensors are thoroughly investigated and compared. Importantly, in force sensor applications, the ZnO/ZnMgO coaxial structure results in significantly higher sensitivity and a faster response time when compared to the bare ZnO nanotube. The origin of the improved performance is thoroughly discussed. Furthermore, wireless breath sensing is demonstrated using the ZnO/ZnMgO pressure sensors with custom electronics, demonstrating the feasibility of the sensor technology for health monitoring and the potential diagnosis of sleep apnea.