tbuckley/cabot-search huggingface dataset:
Abstract 4733: Impact of Pericardial Adhesions on Diastolic Transmitral Flow Efficiency: Analysis by Vortex Formation Time
Authors: Panupong Jiamsripong, Mohsen S Alharthi, Anna M Calleja, Eileen M McMahon, Partho P Sengupta, Bijoy K Khandheria, Marek Belohlavek
Journal: Circulation (2008)
Medical school applications
Authors: C. Katona
Journal: BMJ (2003)

# Pool of potential medical students needs to be enlarged {#article-title-2} EDITOR—McManus says that the only way to increase the pool of medical school applicants is to lower A level requirements or to increase the pool of A level chemistry candidates.1 We argue that a better pathway to recruiting successful medical students is to appeal to a much larger pool both of able school pupils and of mature, older graduates and health professionals. Selection from this enlarged pool should be based on overall academic ability, which predicts both the likelihood of staying the course and ultimate success more powerfully than having science A levels and assessment of the personal qualities required to be a good doctor.2–4 The real challenges are of affirmative action (making medicine seem an attractive career to the many young people who have the appropriate potential but are not currently considering it) and of tailoring undergraduate curriculums to meet the needs of students with the necessary scientific reasoning abilities but without the science knowledge base. Specific elements of such a strategy would include:
Therapeutic vaccination against advanced pancreatic cancer by autologous dendritic cells pulsed with a MUC1 peptide: Preclinical results of a clinical phase I trial
Authors: D. Jin, Y. Rong, W. Lou, X. Qin, W. Wu, X. Nin, X. Nin, D. Wang, T. Kuang, Y. Qin
Journal: Journal of Clinical Oncology (2009)

e15652 Background: Pancreatic ductal adenocarcinoma has a particularly poor prognosis. Therefore, novel therapeutic strategies such as immunotherapy are required. The aim of the present phase I study was to evaluate the safety, immune responses and clinical activity of a vaccine based on autologous dendritic cells (DC) pulsed with a specific MUC1 peptide in advanced pancreatic cancer patients. Methods: Five patients who had pancreatic cancer ductal adenocarcinoma expressing MUC1 in stage of III/IV were enrolled to the clinical trial. Patients underwent leukapheresis to generate dendritic cells by culture in vitro with granulocyte macrophage colony-stimulating factor and interleukin-4 for 5 days. Dendritic cells were then pulsed overnight with MUC1 peptide (GVTSAPDTRPAPGSTAPPAH) and harvested for vaccination. Dendritic cells (3×10 6 -6×10 6 ) were injected intradermally every 2 weeks for 3–4 times. Results: All patients remained with progressive disease. Four patients developed strong T-cell IFN-γ and Granzyme B Elispot responses to the vaccine. Most interestingly, the patient who was treated with the highest number of DC(6×10 6 ) had more number of CTL than other patients and showed delayed-type hypersensitivity responses at injection sites and this patient stopped application of the analgetics. Another patient with relapsed pancreatic cancer who had finished the 4 times of vaccination and then followed 6 times of chemotherapy with Gemcitabine had a surprisingly long term of survival of 12 month. No evidence of significant treatment related toxicity or auto-immunity was observed. Conclusions: This study showed the safety and clinical response of MUC1 peptide-pulsed dendritic cell therapy for patients with advanced pancreatic cancer. It confirms the capability of this DC vaccine to stimulate an immune response in patients with pancreatic cancer even in the presence of a large tumor burden. Dendritic cell therapy is recommended for further clinical studies in pancreatic cancer patients. No significant financial relationships to disclose.
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
Authors: Søren D. Østergaard, Shubhabrata Mukherjee, Stephen J. Sharp, Petroula Proitsi, Luca A. Lotta, Felix Day, John R. B. Perry, Kevin L. Boehme, Stefan Walter, John S. Kauwe, Laura E. Gibbons, Eric B. Larson, John F. Powell, Claudia Langenberg, Paul K. Crane, Nicholas J. Wareham, Robert A. Scott
Journal: PLoS Medicine (2015)

Background Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these associations is unclear. We sought to assess the causal nature of these associations using Mendelian randomization (MR). Methods and Findings We used SNPs associated with each risk factor as instrumental variables in MR analyses. We considered type 2 diabetes (T2D, NSNPs = 49), fasting glucose (NSNPs = 36), insulin resistance (NSNPs = 10), body mass index (BMI, NSNPs = 32), total cholesterol (NSNPs = 73), HDL-cholesterol (NSNPs = 71), LDL-cholesterol (NSNPs = 57), triglycerides (NSNPs = 39), systolic blood pressure (SBP, NSNPs = 24), smoking initiation (NSNPs = 1), smoking quantity (NSNPs = 3), university completion (NSNPs = 2), and years of education (NSNPs = 1). We calculated MR estimates of associations between each exposure and AD risk using an inverse-variance weighted approach, with summary statistics of SNP–AD associations from the International Genomics of Alzheimer's Project, comprising a total of 17,008 individuals with AD and 37,154 cognitively normal elderly controls. We found that genetically predicted higher SBP was associated with lower AD risk (odds ratio [OR] per standard deviation [15.4 mm Hg] of SBP [95% CI]: 0.75 [0.62–0.91]; p = 3.4 × 10−3). Genetically predicted higher SBP was also associated with a higher probability of taking antihypertensive medication (p = 6.7 × 10−8). Genetically predicted smoking quantity was associated with lower AD risk (OR per ten cigarettes per day [95% CI]: 0.67 [0.51–0.89]; p = 6.5 × 10−3), although we were unable to stratify by smoking history; genetically predicted smoking initiation was not associated with AD risk (OR = 0.70 [0.37, 1.33]; p = 0.28). We saw no evidence of causal associations between glycemic traits, T2D, BMI, or educational attainment and risk of AD (all p > 0.1). Potential limitations of this study include the small proportion of intermediate trait variance explained by genetic variants and other implicit limitations of MR analyses. Conclusions Inherited lifetime exposure to higher SBP is associated with lower AD risk. These findings suggest that higher blood pressure—or some environmental exposure associated with higher blood pressure, such as use of antihypertensive medications—may reduce AD risk.
Bread: A Collection of Popular Papers on Wheat, Flour and Bread.
Authors: Harry Snyder, Andrew Lincoln Winton
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4678: Surgical versus Percutaneous Revascularization for the Treatment of Patients With Multivessel Disease in the Setting of Acute Coronary Syndromes: Analysis From the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) Trial
Authors: Yanai Ben Gal, Roxana Mehran, Jeffrey W Moses, Giora Weisz, Ramin Ebrahimi, Alexandra J Lansky, Matthew R Williams, Eugenia Nikolsky, Michael Argenziano, Susheel Kodali, Gregg W Stone
Journal: Circulation (2009)
Ethics and psychiatric research: problems and justification
Authors: B Eichelman, D Wikler, A Hartwig
Journal: American Journal of Psychiatry (1984)

The discussion of ethics in psychiatry continues to increase. Research in psychiatry, like all medical research, is of ethical concern because it often involves risks to subjects so that others may benefit. It also involves the allocation of monetary and human resources. In recent years these concerns have been brought to the forefront of professional and public attention. The authors consider the problem of justifying resource allocations and the risks involved in psychiatry research, survey some of the special problems faced by researchers in this field, and give a brief account of present government regulations that pertain to research ethics in psychiatry.
Abstract 266: Peri-Shock Pause: an Independent Predictor of Survival From Out-of-Hospital Shockable Cardiac Arrest
Authors: Sheldon Cheskes, Robert H Schmicker, Jim Christenson, James J Menegazzi, Tom Rea, Judy Powell, Susanne May, David D Salcido, Michele Olsufka, Sarah Pennington, Jacob Simonini, Dana Edelson, Ian Stiell, Robert A Berg, Lois Van Ottingham, Ahamed Idris, Rebecca Sell, Blair Bigham, Laurie Morrison
Journal: Circulation (2010)

Introduction: Peri-shock pauses, defined as the pauses before and after defibrillatory shock interrupt chest compressions and are associated with reduced defibrillation success rates. We examined t...
The Deubiquitinating Enzymes Of The 19S Proteasome Offer Novel Therapeutic Opportunity In Bortezomib Resistant Waldenströms Macroglobulinemia
Authors: Aneel Paulus, Kasyapa S. Chitta, Sharoon Akhtar, Maja Kuranz, Vivek Roy, Stephen M Ansell, Anne J. Novak, Peter Martin, Richard R. Furman, Morton Coleman, Stig Linder, Asher Chanan-Khan
Journal: Blood (2013)
THE INTERNIST AND THE SYPHILIS CONTROL PROGRAM
Authors: Hugh J. Morgan
Journal: Annals of Internal Medicine (1937)

Article1 September 1937THE INTERNIST AND THE SYPHILIS CONTROL PROGRAMHUGH J. MORGAN, M.D., F.A.C.P.HUGH J. MORGAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-3-469 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmong the objectives of the American College of Physicians that have been enumerated in the articles of its Constitution are: "maintaining and advancing the highest possible standards in medical education and medical practice; . . . maintaining both the dignity and efficiency of internal medicine in its relationship to public welfare; . . . to foster measures for the prevention of disease and for improving public health." If the College is to maintain these purposes and ideals, the fullest participation on the part of the membership is required in the current program for the control of syphilis, for this is...References1. PARRAN T: The next great plague to go, Survey Graphic, 1936, xxv, 405. Google Scholar2. VONDERLEHR RA: Prevalence, incidence and trend of syphilis, Conference on Venereal Disease Control Work, Washington, D. C., December 28-30, 1936. Supplement No. 3 to Venereal Disease Information, United States Treasury Department. Google Scholar3. PARRAN T: Eradication of syphilis as a practical public health objective, Jr. Am. Med. Assoc., 1931, xcvii, 73. CrossrefGoogle Scholar4. MOORE JE: The modern treatment of syphilis, 1933, Charles C. Thomas, Baltimore. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HUGH J. MORGAN, M.D., F.A.C.P.Affiliations: Nashville, Tennessee*Read at the St. Louis meeting of the American College of Physicians, April 21, 1937.From the Department of Medicine, Vanderbilt Medical School, Nashville, Tennessee. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1937Volume 11, Issue 3 Page: 469-473 Keywords Medical education Prevention, policy, and public health Syphilis ePublished: 1 December 2008 Issue Published: 1 September 1937 PDF downloadLoading ...
Angiotensinogen and AT1-receptor gene polymorphisms are related to regression of left ventricular mass during AT1-receptor antagonist treatment in hypertensives
Authors: L Kurland, H Melhus, J Karlsson, T Kahan, K Malmqvist, P Ohman, F Nystrom, A Hagg, L Lind
Journal: Circulation (2001)

Angiotensinogen and AT1-receptor gene polymorphisms are related to regression of left ventricular mass during AT1-receptor antagonist treatment in hypertensives
Frequent Activating Mutations Of JAK-STAT Pathway Genes In Natural Killer Cell Lymphomas
Authors: Can Kucuk, Bei Jiang, Xiaozhou Hu, Philippe Gaulard, Wenyan Zhang, Wenming Xiao, Louis M. Staudt, Javeed Iqbal, Weiwei Zhang, Adam Cornish, Pinar Kavak, Can Alkan, Qiang Gong, Qunpei Yang, Hong Sun, Francesco d'Amore, Sirpa Leppa, Weiping Liu, Timothy McKeithan, Wing C. Chan
Journal: Blood (2013)
Pulmonary Embolism and PO_2
Authors: DENNIS BAUMAN
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 November 1971Pulmonary Embolism and PO2DENNIS BAUMAN, M.D.DENNIS BAUMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-5-806_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their recent paper "Diagnostic Sensitivity of Laboratory Findings in Acute Pulmonary Embolism" (Ann Intern Med 74:161-166, 1971) Szucs and associates state that:We believe that the sensitivity of the lung scan and the arterial PO2 permits exclusion of the diagnosis of acute pulmonary embolism if either test is normal.We recently cared for a patient with a well-documented acute pulmonary embolis and a normal arterial PO2.Mr. M.S., a 40-year-old man, underwent medial menisectomy on 4 June 1971. His convalescence was uneventful until early on the morning of 19 June, when he noticed the sudden onset... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DENNIS BAUMAN, M.D.Affiliations: Cardiology Division Salt Lake V. A. Hospital Salt Lake City, Utah PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1971Volume 75, Issue 5Page: 806-807KeywordsConvalescenceLungsPartial pressure of oxygenPulmonary embolismResearch laboratories ePublished: 1 December 2008 Issue Published: 1 November 1971 PDF downloadLoading ...
Abstract 9676: Additive Prognostic Value of Diastolic Dysfunction and Coronary Flow Reserve in Non-Ischemic Dilated Cardiomyopathy
Authors: Quirino Ciampi, Fausto Rigo, Lorenza Pratali, Sonia Gherardi, Lauro Cortigiani, Bruno Villari, Eugenio Picano, Rosa Sicari
Journal: Circulation (2011)

Background. Coronary flow reserve (CFR) on left anterior descending (LAD) can be reduced in non-ischemic dilated cardiomyopathy (DCM). Aim of the study was to assess the additive prognostic value of CFR in LAD and resting severe diastolic dysfunction to identify responders to CRT. Methods. One hundred twenty-nine DCM patients (pts, 87 men, 62±12 years, ejection fraction: 33±7%) underwent dipyridamole (0.84 mg/kg in 6′) stress echo. CFR was defined as the ratio between maximal vasodilation and rest peak diastolic flow velocity in LAD, and diastolic dysfunction as the presence of resting irreversible restrictive transmitral pattern. Results. We divided DCM pts in 4 groups, according to normal (&gt;2, 56 pts) or abnormal (≤2, 73 pts) CFR on LAD and absence (88 pts) or presence (41 pts) of restrictive transmitral pattern. In pts with abnormal CFR on LAD, the additional presence of restrictive patterns was associated to lower ejection fraction at rest (26±5% vs 31±7% p=.007) and at peak stress (30±5% vs 36±8% p=.03) and larger end-systolic volume at rest (149±55 ml vs 185±48, p=.030). During median follow-up of 30 months, 19 deaths, and 33 cardiac adverse events. Abnormal CFR on LAD and diastolic dysfunction were associated with poorer event-free survival (Log Rank: 33.1, p&lt;0.0001, Figure), with additive negative prognostic value in pts with CFR on LAD &lt;2 and the presence of restrictive pattern. Conclusions. In DCM patients with reduced CFR left anterior descending territory during vasodilator stress, the associate presence of restrictive transmitral pattern is an additive independent prognostic marker of bad prognosis.
Abstract 6260: Up-Regulated Expression of MicroRNA-143 in Association with Obesity in the Adipose Tissue of Mice Fed High Fat Diet
Authors: Rieko Takanabe, Koh Ono, Tomohide Takaya, Takahiro Horie, Hiromichi Wada, Toru Kita, Akira Shimatsu, Koji Hasegawa
Journal: Circulation (2008)

Obesity is the result of an expansion and increase in the number of individual adipocytes. Since changes in gene expression during adipocyte differentiation and hypertrophy are closely associated with insulin resistance and cardiovascular diseases, further insight into the molecular basis of obesity is needed to better understand obesity-associated diseases. MicroRNAs (miRNAs) are approximately 17–24nt single stranded RNA, that post-transcriptionally regulate gene expression. MiRNAs control cell growth, differentiation and metabolism, and may be also involved in pathogenesis and pathophysiology of diseases. It has been proposed that miR-143 plays a role in the differentiation of preadipocytes into mature adipocytes in culture. However, regulated expression of miR-143 in the adult adipose tissue during the development of obesity in vivo is unknown. To solve this problem, C57BL/6 mice were fed with either high-fat diet (HFD) or normal chow (NC). Eight weeks later, severe insulin resistance was observed in mice on HFD. Body weight increased by 35% and the mesenteric fat weight increased by 3.3-fold in HFD mice compared with NC mice. We measured expression levels of miR-143 in the mesenteric fat tissue by real-time PCR and normalized with those of 5S ribosomal RNA. Expression of miR-143 in the mesenteric fat was significantly up-regulated (3.3-fold, p&lt;0.05) in HFD mice compared to NC mice. MiR-143 expression levels were positively correlated with body weight (R=0.577, p=0.0011) and the mesenteric fat weight (R=0.608, p=0.0005). We also measured expression levels in the mesenteric fat of PPARγ and AP2, whose expression are deeply involved in the development of obesity, insulin resistant and arteriosclerosis. The expression levels of miR-143 were closely correlated with those of PPARγ (R=0.600, p=0.0040) and AP2 (R=0.630, p=0.0022). These findings provide the first evidence for up-regulated expression of miR-143 in the mesenteric fat of HFD-induced obese mice, which might contribute to regulated expression of genes involved in the pathophysiology of obesity.
Abstract 3319: Autologous Transplantation of Peripheral Blood Mononuclear Cells for Patients with Peripheral Artery Diseases; Long Term Outcomes
Authors: Kaoru Tateno, Junji Moriya, Tohru Minamino, Kentaro Miura, Naomi Shimizu, Yoshio Kobayashi, Issei Komuro
Journal: Circulation (2007)

Mononuclear cell (MNC) transplantation for peripheral artery diseases (PAD) has become prevalent. However, long-term outcomes of this novel therapeutic strategy have not been documented in details. We had extended the observation period following peripheral blood (PB) MNC transplantation for severe PAD, and obtained clinical data suggesting beneficial yet caution requiring effect of therapeutic neovascularization. Indications for intervention were severe rest pain (36/42, 86%), ischemic ulcer of lower limbs (30/42, 71%), or severe intermittent claudication compromising their ADL (6/42, 14%). Altogether, 42 patients (34 men, 8 women; average age 61 +/− 14 years) underwent 94 transplantations. Sixty seven percents (28/42) of the patients were diagnosed as arteriosclerosis obliterans (ASO), and the remainders were thromboangiitis obliterans (TAO). Co-morbidities included diabetes (21/42 50%) and chronic renal insufficiency treated by dialysis (19/42 45%). Early phase (~6 months) success, defined by improvement in either rest pain, ischemic ulcer, or walking distance, was achieved in 76% (32/42) of the patients. During the long-term follow up (average 30+/− 10 months range 6 –50 months), 85% (17/20) of the responding patients were safe from the relapse of ischemic ulcers, and 89% (23/26) were maintained rest pain free. Limb salvage was 91 % (4/42) at early phase, and 97 % (33/34) during the late follow up period. While there were no major adverse events seen in the TAO patients, 32% (9/28) of the ASO patients had suffered the progression of atherosclerosis in their long term follow-up. There were 11 deaths among 28 ASO patients (39%) in the same period, which were notably associated with the presence of renal insufficiency. In the group of patients undergoing hemo-dialyses, responses to the treatment seemed to correlate with their prognosis, suggesting that improved QOL by the cell therapy may have some good contribution on their survival. In conclusion, PBMNC transplantation for severe PAD is a safe and durable intervention for non-ASO patients without renal failure. However, careful and discrete case selection, in company with stringent follow up of atherosclerosis, is critically advisable for ASO patients with severe renal insufficiency.
Abstract 14898: Cardiac-Restricted Overexpression of Liver X Receptor Attenuates Adverse Cardiac Remodeling
Authors: Megan V Cannon, Herman H Silljé, Linda van Genne, Inge Vreeswijk-Baudoin, Wiek H van Gilst, Rudolf A De Boer
Journal: Circulation (2011)

Background - Liver X Receptor (LXR) agonists have been studied for their potential antihypertrophic effects on the heart. However, LXR agonists elicit severe systemic side-effects such as hypertrig...
Mortality, disability, and intensive care in patients with mitochondrial 3243A>G mutation
Authors: Han-Chung Hsiue, Ni-Chung Lee, Hung-Bin Tsai, Chih-Chao Yang, Chao-Szu Wu, Wang-Tso Lee, Wen-Chin Weng, Pi-Chuan Fan, Yin-Hsiu Chien, Wuh-Liang Hwu, Kun-Long Hung, Chao-Ching Huang, Chih-Hung Chen, Shio-Jean Lin, Shao-Yin Chu, Tzu-Jou Wang, Chien-Jung Lu, Pei-Lin Lee
Journal: Intensive Care Medicine (2015)