tbuckley/cabot-search huggingface dataset:
Multistep endoscopic approach for recalcitrant colorectal anastomosis
Authors: Jaime Escobar Ortiz, Jorge Pérez Pérez, José Carlos Villa Poza, Francisco Garrido, Marta Castillo, Ángel Ponferrada Díaz, Álvaro Martínez Alcalá García
Journal: Endoscopy (2024)

We present the case of a 69-year-old man with a history of sigmoid colon adenocarcinoma pN1c treated by laparoscopic sigmoidectomy who required a Hartmann's intervention for anastomotic dehiscence. The patient subsequently underwent reconstruction of the colon by terminolateral anastomosis. However, he then developed a symptomatic stenosis in the region of the colorectal anastomosis, which resulted in recurrent subocclusive episodes.
A migrating fishbone
Authors: Lei Shi, SaiLing Wei, Qiong Yan, Jia Xun Xie, JinYu Wu, Lisheng Wang
Journal: Endoscopy (2024)

A 65-year-old man presented to our hospital having had epigastric discomfort for 1 month. Abdominal computed tomography (CT) demonstrated a strip of high density shadow in the medial wall of the gastric antrum ([Fig. 1]). After a detailed medical history had been taken, the patient recalled the ingestion of fish 1 month previously.
Endoscopic incision of malignant stenosis for the retrieval of a retained capsule endoscope
Authors: Takashi Taida, Ryosuke Horio, Kenichiro Okimoto, Yuki Ohta, Tomoaki Matsumura, Jun Kato, Naoya Kato
Journal: Endoscopy (2024)

Capsule endoscopy is one of the least invasive options for enteroscopy, allowing detailed observation of the entire small intestine. However, capsule retention can occur, particularly in patients with small-intestinal stenosis, which may require surgical retrieval in some cases [1]. In cases of capsule retention due to small-intestinal stenosis in Crohn's disease or other benign lesions, retrieval using balloon enteroscopy has recently been performed. Endoscopic retrieval involving stenosis dilation has also been reported [2] [3] [4]. Here, we report a case of successful endoscopic retrieval of a capsule endoscope retained in a malignant tumor through an incision made using a needle-knife ([Video 1]).
Novel method for retrieving a migrated plastic stent using an 11.5-Fr pusher sheath: The stent encapsulation method
Authors: Fumitaka Niiya, Masataka Yamawaki, Jun Noda, Tetsushi Azami, Yuichi Takano, Fumiya Nishimoto, Masatsugu Nagahama
Journal: Endoscopy (2024)

Plastic stent placement using endoscopic retrograde cholangiopancreatography (ERCP) is a widely used biliary drainage technique [1]. Migration of the plastic stent is a major adverse effect. Retrieval grasping techniques using baskets, snares, forceps, and balloon catheters have been reported [2]; however, these techniques are not always successful because of biliary stenosis and tight anchoring of plastic stent flaps [3]. Herein, we introduce a novel method for retrieving a migrated plastic stent using an 11.5-Fr pusher sheath.
Single-session endoscopic ultrasound-guided hepaticogastrostomy and enteral stenting using forward-viewing endoscopic ultrasonography for malignant biliary and duodenal obstruction
Authors: Kenji Nakamura, Sakiko Takarabe, Tadashi Katayama, Masataka Ichikawa, Keisuke Ojiro, Hiroshi Kishikawa, Jiro Nishida
Journal: Endoscopy (2024)

Recently, endoscopic biliary and enteral stenting techniques, including the use of endoscopic ultrasound (EUS), have been developed for patients with malignant biliary obstruction (MBO) and malignant gastric outlet obstruction (GOO) [1] [2] [3] [4]. However, when these conditions are encountered simultaneously, including during reintervention, the use of this strategy remains controversial [5].
Infected percutaneous transhepatic cholangiography catheter and rescue hepaticogastrostomy in patient with gallbladder carcinoma
Authors: Sevil Tokdemir Sisman, Can Boynukara, Gurhan Sisman
Journal: Endoscopy (2024)

We present the case of a 58-year-old man with stage IV gallbladder carcinoma. The metastases of the liver caused obstructive jaundice, and due to the choledochal, cystic, and intrahepatic biliary duct metastases, endoscopic retrograde cholangiopancreatography (ERCP) was unsuccessful. Therefore, percutaneous transhepatic cholangiography (PTC) was performed.
Endoscopic submucosal dissection of recurrent duodenal adenoma: combined use of multiple strategies for a difficult case
Authors: Ludovico Alfarone, Jérémie Albouys, Romain Legros, Mathieu Pioche, Timothée Wallenhorst, Sophie Geyl, Jérémie Jacques
Journal: Endoscopy (2024)

The duodenal anatomy, which involves a thin muscle layer and rich vascularization, makes endoscopic resection harder and more dangerous in this region than in other regions of the gastrointestinal tract. Additionally, the physiological shape of the stomach decreases endoscope maneuverability. Thus, large non-ampullary duodenal adenomas are usually removed through snare-based techniques because endoscopic submucosal dissection (ESD) is considered excessively hazardous. However, in select difficult cases, ESD may be the sole viable option for successful resection [1].
Association of accelerometer-measured physical activity and its change with progression to chronic kidney disease in adults with type 2 diabetes and overweight/obesity
Authors: Mengyi Liu, Yanjun Zhang, Yuanyuan Zhang, Panpan He, Chun Zhou, Ziliang Ye, Sisi Yang, Xiaoqin Gan, Fan Fan Hou, Xianhui Qin
Journal: British Journal of Sports Medicine (2024)

Objective To examine the long-term association of objectively measured moderate-to-vigorous physical activity (MVPA) and its longitudinal changes with progression to chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) and overweight/obesity. Methods This study included 1746 participants in the Look AHEAD trial with baseline estimated glomerular filtration rate (eGFR)≥60 mL/min/1.73 m 2 . MVPA was measured at baseline, year 1, year 4 and year 8 using an RT3 accelerometer. The outcome was progression to CKD, defined as eGFR&lt;60 mL/min per 1.73 m 2 with a drop of ≥30% or end-stage kidney disease. Cox hazards models were fitted to examine the association between MVPA and outcomes. Results Over a median follow-up of 12.0 years, 567 participants experienced progression to CKD. Overall, there was a linear inverse association of cumulative average total MVPA (per 100 min/week higher amount, HR: 0.91; 95% CI: 0.86 to 0.96) and MVPA accumulated in bouts of ≥10 min (per 100 minutes/week higher amount, HR: 0.81; 95% CI: 0.72 to 0.91) with progression to CKD. Moreover, an increase in total MVPA from baseline to year 4 (the fourth quartile, ≥63.2 min/week) was associated with a 33% lower risk of progression to CKD compared with the largest MVPA reduction (the first quartile, &lt;−198.3 min/week). A lower risk of progression to CKD was also observed for increases in MVPA accumulated in bouts of both &lt;10 min and ≥10 min. Conclusions Longer MVPA time and increases in MVPA was associated with a reduced risk of progression to CKD in adults with overweight/obesity and T2D.
Neuroadaptive Bayesian optimisation can allow integrative design spaces at the individual level in the social and behavioural sciences… and beyond
Authors: Rianne Haartsen, Anna Gui, Emily J. H. Jones
Journal: Behavioral and Brain Sciences (2024)

Abstract Almaatouq et al. propose an integrative experiment design space combined with large samples for scientific advancement. We argue recent innovative designs combining closed-loop experiment designs and Bayesian optimisation allow for integrative experiments at an individual level during a single session, circumventing the necessity for large samples. This method can be applied across disciplines, including developmental and clinical research.
Experiment commensurability does not necessitate research consolidation
Authors: Milena Tsvetkova
Journal: Behavioral and Brain Sciences (2024)

Integrative experiment design promises to foster cumulative knowledge by changing how we design experiments, build theories, and conduct research. I support the push to increase commensurability across experimental research but raise several reservations regarding results-driven and large-team-based research. I argue that it is vital to preserve academic diversity and adversarial debate via independent efforts.
Replies to commentaries on beyond playing 20 questions with nature
Authors: Abdullah Almaatouq, Thomas L. Griffiths, Jordan W. Suchow, Mark E. Whiting, James Evans, Duncan J. Watts
Journal: Behavioral and Brain Sciences (2024)

Abstract Commentaries on the target article offer diverse perspectives on integrative experiment design. Our responses engage three themes: (1) Disputes of our characterization of the problem, (2) skepticism toward our proposed solution, and (3) endorsement of the solution, with accompanying discussions of its implementation in existing work and its potential for other domains. Collectively, the commentaries enhance our confidence in the promise and viability of integrative experiment design, while highlighting important considerations about how it is used.
Phenomena complexity, disciplinary consensus, and experimental versus correlational research in psychological science
Authors: Dean Keith Simonton
Journal: Behavioral and Brain Sciences (2024)

Abstract The target article ignores the crucial role of correlational methods in the behavioral and social sciences. Yet such methods are often mandated by the greater complexity of the phenomena investigated. This necessity is especially conspicuous in psychological research where its position in the hierarchy of the sciences implies the need for both experimental and correlational investigations, each featuring distinct assets.
Dimensional versus conceptual incommensurability in the social and behavioral sciences
Authors: Eugene Vaynberg, Kate Nicole Hoffman, Jacqueline Mae Wallis, Michael Weisberg
Journal: Behavioral and Brain Sciences (2024)

Abstract This commentary analyzes the extent to which the incommensurability problem can be resolved through the proposed alternative method of integrative experiment design. We suggest that, although one aspect of incommensurability is successfully addressed ( dimensional incommensurability ), the proposed design space method does not yet alleviate another major source of discontinuity, which we call conceptual incommensurability .
Against naïve induction from experimental data
Authors: David Kellen, Gregory E. Cox, Chris Donkin, John C. Dunn, Richard M. Shiffrin
Journal: Behavioral and Brain Sciences (2024)

Abstract This commentary argues against the indictment of current experimental practices such as piecemeal testing, and the proposed integrated experiment design (IED) approach, which we see as yet another attempt at automating scientific thinking. We identify a number of undesirable features of IED that lead us to believe that its broad application will hinder scientific progress.
Is generalization decay a fundamental law of psychology?
Authors: David R. Mandel
Journal: Behavioral and Brain Sciences (2024)

Abstract Generalizations strengthen in traditional sciences, but in psychology (and social and behavioral sciences, more generally) they decay. This is usually viewed as a problem requiring solution. It could be viewed instead as a law-like phenomenon. Generalization decay cannot be squelched because human behavior is metastable and all behavioral data collected thus far have resulted from a thin sliver of human time.
Consensus meetings will outperform integrative experiments
Authors: Maximilian A. Primbs, Leonie A. Dudda, Pia K. Andresen, Erin M. Buchanan, Hannah K. Peetz, Miguel Silan, Daniël Lakens
Journal: Behavioral and Brain Sciences (2024)

We expect that consensus meetings, where researchers come together to discuss their theoretical viewpoints, prioritize the factors they agree are important to study, standardize their measures, and determine a smallest effect size of interest, will prove to be a more efficient solution to the lack of coordination and integration of claims in science than integrative experiments.
Are language–cognition interactions bigger than a breadbox? Integrative modeling and design space thinking temper simplistic questions about causally dense phenomena
Authors: Debra Titone, Esteban Hernández-Rivera, Antonio Iniesta, Anne L. Beatty-Martínez, Jason W. Gullifer
Journal: Behavioral and Brain Sciences (2024)

Abstract We affirm the utility of integrative modeling, according to which it is advantageous to move beyond “one-at-a-time binary paradigms” through studies that position themselves within realistic multidimensional design spaces. We extend the integrative modeling approach to a target domain with which we are familiar, the consequences of bilingualism on mind and brain, often referred to as the “bilingual advantage.” In doing so, we highlight work from our group consistent with integrative modeling.
Measurement validity and the integrative approach
Authors: Wendy C. Higgins, Alexander J. Gillett, Eliane Deschrijver, Robert M. Ross
Journal: Behavioral and Brain Sciences (2024)

Abstract Almaatouq et al. propose a novel integrative approach to experiments. We provide three examples of how unaddressed measurement issues threaten the feasibility of the approach and its promise of promoting commensurability and knowledge integration.
Beyond integrative experiment design: Systematic experimentation guided by causal discovery AI
Authors: Erich Kummerfeld, Bryan Andrews
Journal: Behavioral and Brain Sciences (2024)

Integrative experiment design is a needed improvement over ad hoc experiments, but the specific proposed method has limitations. We urge a further break with tradition through the use of an enormous untapped resource: Decades of causal discovery artificial intelligence (AI) literature on optimizing the design of systematic experimentation.
Assume a can opener
Authors: Cory J. Clark, Calvin Isch, Paul Connor, Philip E. Tetlock
Journal: Behavioral and Brain Sciences (2024)

We propose a friendly amendment to integrative experiment design (IED), adversarial-collaboration IED, that incentivizes research teams from competing theoretical perspectives to identify zones of the design space where they possess an explanatory edge. This amendment is especially critical in debates that have high policy stakes and carry a strong normative-political charge that might otherwise prevent free exchange of ideas.
Discovering the unknown unknowns of research cartography with high-throughput natural description
Authors: Tanay Katiyar, Jean-François Bonnefon, Samuel A. Mehr, Manvir Singh
Journal: Behavioral and Brain Sciences (2024)

Abstract To succeed, we posit that research cartography will require high-throughput natural description to identify unknown unknowns in a particular design space. High-throughput natural description, the systematic collection and annotation of representative corpora of real-world stimuli, faces logistical challenges, but these can be overcome by solutions that are deployed in the later stages of integrative experiment design.
The future of experimental design: Integrative, but is the sample diverse enough?
Authors: Sakshi Ghai, Sanchayan Banerjee
Journal: Behavioral and Brain Sciences (2024)

Almaatouq et al. propose an "integrative approach" to increase the generalisability and commensurability of experiments. Yet their metascientific approach has one glaring omission (and misinterpretation of) - the role of sample diversity in generalisability. In this commentary, we challenge false notions of subsumed duality between contexts, population, and diversity, and propose modifications to their design space to accommodate sample diversity.
Confidence in research findings depends on theory
Authors: David Gal, Brian Sternthal, Bobby J. Calder
Journal: Behavioral and Brain Sciences (2024)

Almaatouq et al. view the purpose of research is to map variable-to-variable relationships (e.g., the effect of X on Y). They also view theory as this mapping of variable-to-variable relationships rather than an explanation of why the relationships occur. However, it is theory as explanation that allows us to reconcile disparate findings and that should guide application.
The miss of the framework
Authors: Paul E. Smaldino
Journal: Behavioral and Brain Sciences (2024)

Abstract The authors rightly critique existing social sciences approaches. However, they are too quick to dismiss the criticism that their proposed paradigm is atheoretical. Social and cognitive theories are indeed incommensurate, often due to the lack of a unifying framework. Without proper integration with theoretical frameworks, their proposal may merely produce a resource-intensive veneer of thoroughness without substantive improvements to understanding.
Commensurability engineering is first and foremost a theoretical exercise
Authors: Joachim Vandekerckhove
Journal: Behavioral and Brain Sciences (2024)

I provide a personal perspective on metastudies and emphasize lesser-known benefits. I stress the need for integrative theories to establish commensurability between experiments. I argue that mathematical social scientists should be engaged to develop integrative theories, and that likelihood functions provide a common mathematical framework across experiments. The development of quantitative theories promotes commensurability engineering on a larger scale.
Test many theories in many ways
Authors: Wilson Cyrus-Lai, Warren Tierney, Eric Luis Uhlmann
Journal: Behavioral and Brain Sciences (2024)

Abstract Demonstrating the limitations of the one-at-a-time approach, crowd initiatives reveal the surprisingly powerful role of analytic and design choices in shaping scientific results. At the same time, cross-cultural variability in effects is far below the levels initially expected. This highlights the value of “medium” science, leveraging diverse stimulus sets and extensive robustness checks to achieve integrative tests of competing theories.
Integrative design for thought-experiments
Authors: Daniel Dohrn, Angelica Mezzadri
Journal: Behavioral and Brain Sciences (2024)

Abstract Integrative experiment design should be extended to thought-experiments. Thought-experiments are closely connected to “real” experiments. They are involved in devising the design space of theories and possible experiments. The latter may be partitioned into experiments to be really performed and mere thought-experiments. The proposed extension of integrative experiment design lends guidance to a more methodical performance of thought-experiments.
Getting lost in an infinite design space is no solution
Authors: Mario Gollwitzer, Johannes Prager
Journal: Behavioral and Brain Sciences (2024)

Almaatouq et al. argue that an "integrative experiment design" approach can help generating cumulative empirical and theoretical knowledge. Here, we discuss the novelty of their approach and scrutinize its promises and pitfalls. We argue that setting up a "design space" may turn out to be theoretically uninformative, inefficient, and even impossible. Designing truly diagnostic experiments provides a better alternative.
Explore your experimental designs and theories before you exploit them!
Authors: Marina Dubova, Sabina J. Sloman, Ben Andrew, Matthew R. Nassar, Sebastian Musslick
Journal: Behavioral and Brain Sciences (2024)

Abstract In many areas of the social and behavioral sciences, the nature of the experiments and theories that best capture the underlying constructs are themselves areas of active inquiry. Integrative experiment design risks being prematurely exploitative, hindering exploration of experimental paradigms and of diverse theoretical accounts for target phenomena.
Sampling complex social and behavioral phenomena
Authors: Henrik Olsson, Mirta Galesic
Journal: Behavioral and Brain Sciences (2024)

Abstract We comment on the limits of relying on prior literature when constructing the design space for an integrative experiment; the adaptive nature of social and behavioral phenomena and the implications for the use of theory and modeling when constructing the design space; and on the challenges of measuring random errors and lab-related biases in measurement without replication.
Representative design: A realistic alternative to (systematic) integrative design
Authors: Gijs A. Holleman, Mandeep K. Dhami, Ignace T. C. Hooge, Roy S. Hessels
Journal: Behavioral and Brain Sciences (2024)

Abstract We disagree with Almaatouq et al. that no realistic alternative exists to the “one-at-a-time” paradigm. Seventy years ago, Egon Brunswik introduced representative design , which offers a clear path to commensurability and generality. Almaatouq et al.'s integrative design cannot guarantee the external validity and generalizability of results which is sorely needed, while representative design tackles the problem head on.
The elephant's other legs: What some sciences actually do
Authors: Jonathan Baron
Journal: Behavioral and Brain Sciences (2024)

Abstract Integrative experiments, as described, seem blindly empirical, as if the question of generality of effects could not be understood through controlled one-at-a-time experiments. But current research using such experiments, especially applied research, can resolve issues and make progress through understanding of cause–effect pathways, leaving to engineers the task of translating this understanding into practice.
Eliminativist induction cannot be a solution to psychology's crisis
Authors: Mehmet Necip Tunç, Duygu Uygun Tunç
Journal: Behavioral and Brain Sciences (2024)

Abstract Integrative experiment design assumes that we can effectively design a space of factors that cause contextual variation. However, this is impossible to do so in a sufficiently objective way, resulting inevitably in observations laden with surrogate models. Consequently, integrative experiment design may even deepen the problem of incommensurability. In comparison, one-at-a-time approaches make much more tentative assumptions about the factors excluded from experiment design, hence still seem better suited to deal with incommensurability.
Don't let perfect be the enemy of better: In defense of unparameterized megastudies
Authors: Wei Li, Joshua K. Hartshorne
Journal: Behavioral and Brain Sciences (2024)

Abstract The target article argues researchers should be more ambitious, designing studies that systematically and comprehensively explore the space of possible experiments in one fell swoop. We argue that while “systematic” is rarely achievable, “comprehensive” is often enough. Critically, the recent popularization of massive online experiments shows that comprehensive studies are achievable for most cognitive and behavioral research questions.
The social sciences needs more than integrative experimental designs: We need better theories
Authors: Moshe Hoffman, Tadeg Quillien, Bethany Burum
Journal: Behavioral and Brain Sciences (2024)

Abstract Almaatouq et al.'s prescription for more integrative experimental designs is welcome but does not address an equally important problem: Lack of adequate theories. We highlight two features theories ought to satisfy: “Well-specified” and “grounded.” We discuss the importance of these features, some positive exemplars, and the complementarity between the target article's prescriptions and improved theorizing.
There are no shortcuts to theory
Authors: Berna Devezer
Journal: Behavioral and Brain Sciences (2024)

Almaatouq et al. claim that the integrative experiment design can help "develop a reliable, cohesive, and cumulative theoretical understanding." I will contest this claim by challenging three underlying assumptions about the nature of scientific theories. I propose that the integrative experiment design should be viewed as an exploratory framework rather than a means to build or evaluate theories.