tbuckley/cabot-search huggingface dataset:
Multifunctional Composite Scaffold with Nano‐silver, Graphene Oxide, and Macrophage Membrane Vesicles for Sequential Treatment of Infected Bone Defects
Authors: Mingjie Sun, Yang Lu, Hongrui Zhang, Weiqian Jiang, Wenzhao Wang, Xiao Huang, Shichun Zhang, Dulei Xiang, Boyu Tang, Yu Chen, Tingmei Chen, Chengjie Lian, Jian Zhang
Journal: Advanced Healthcare Materials (2024)

Abstract The management of infected bone defects poses a significant clinical challenge, and current treatment modalities exhibit various limitations. This study focuses on the development of a multifunctional composite scaffold comprising nanohydroxyapatite/polyethyleneglycol diacrylate matrix, silver nanoparticles, graphene oxide (GO), sodium alginate, and M2‐type macrophage membrane vesicles (MVs) to enhance the healing of infected bone defects. The composite scaffold demonstrates several key features: first, it releases sufficient quantities of silver ions to effectively eliminate bacteria; second, the controlled release of MVs leads to a notable increase in M2‐type macrophages, thereby significantly mitigating the inflammatory response. Additionally, GO acts synergistically with nanohydroxyapatite to enhance osteoinductive activity, thereby fostering bone regeneration. Through meticulous in vitro and in vivo investigations, the composite scaffold exhibits broad‐spectrum antimicrobial effects, robust immunomodulatory capabilities, and enhanced osteoinductive activity. This multifaceted composite scaffold presents a promising approach for the sequential treatment of infected bone defects, addressing the antimicrobial, immunomodulatory, and osteogenic aspects. This study introduces innovative perspectives and offers new and effective treatment alternatives for managing infected bone defects.
Sodium–Glucose Cotransporter-2 Inhibitors and the Risk for Dialysis and Cardiovascular Disease in Patients With Stage 5 Chronic Kidney Disease
Authors: Fu-Shun Yen, Chii-Min Hwu, Jia-Sin Liu, Yi-Ling Wu, Keong Chong, Chih-Cheng Hsu
Journal: Annals of Internal Medicine (2024)

No studies have reported the long-term outcomes of initiating sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with estimated glomerular filtration rates less than 20 mL/min/1.73 m
Photo‐tuning of Hyaluronic‐acid‐based Hydrogel Properties to Control Network Formation in Human Vascular Endothelial Cells
Authors: Kelum Chamara Manoj Lakmal Elvitigala, Lakshmi Mohan, Wildan Mubarok, Shinji Sakai
Journal: Advanced Healthcare Materials (2024)

In vitro network formation by endothelial cells serves as a fundamental model for studies aimed at understanding angiogenesis. The morphogenesis of these cells to form a network is intricately regulated by the mechanical and biochemical properties of the extracellular matrix. Here the effects of modulating these properties in hydrogels derived from phenolated hyaluronic acid (HA-Ph) and phenolated gelatin (Gelatin-Ph) are presented. Visible-light irradiation in the presence of tris(2,2'-bipyridyl)ruthenium(II) chloride hexahydrate and sodium persulfate induces the crosslinking of these polymers, thereby forming a hydrogel and degrading HA-Ph. Human vascular endothelial cells form networks on the hydrogel prepared by visible-light irradiation for 45 min (42 W cm
Cancer incidence, treatment, and survival in the prison population compared with the general population in England: a population-based, matched cohort study
Authors: Margreet Lüchtenborg, Jennie Huynh, Jo Armes, Emma Plugge, Rachael M Hunter, Renske Visser, Rachel M Taylor, Elizabeth A Davies
Journal: The Lancet Oncology (2024)

The growing and ageing prison population in England makes accurate cancer data of increasing importance for prison health policies. This study aimed to compare cancer incidence, treatment, and survival between patients diagnosed in prison and the general population.
Safety and immunogenicity of a polyvalent DNA–protein HIV vaccine with matched Env immunogens delivered as a prime–boost regimen or coadministered in HIV-uninfected adults in the USA (HVTN 124): a phase 1, placebo-controlled, double-blind randomised controlled trial
Authors: Ian Frank, Shuying S Li, Nicole Grunenberg, Edgar T Overton, Samuel T Robinson, Hua Zheng, Kelly E Seaton, Jack R Heptinstall, Mary A Allen, Kenneth H Mayer, Daniel A Culver, Michael C Keefer, Sri Edupuganti, Michael N Pensiero, Vijay L Mehra, Stephen C De Rosa, Daryl E Morris, Shixia Wang, Michael S Seaman, David C Montefiori, Guido Ferrari, Georgia D Tomaras, James G Kublin, Lawrence Corey, Shan Lu
Journal: The Lancet HIV (2024)
Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer (TOPAZ-1): patient-reported outcomes from a randomised, double-blind, placebo-controlled, phase 3 trial
Authors: Howard A Burris, Takuji Okusaka, Arndt Vogel, Myung Ah Lee, Hidenori Takahashi, Valeriy Breder, Jean-Frédéric Blanc, Junhe Li, Melinda Bachini, Magdalena Żotkiewicz, Jayne Abraham, Nikunj Patel, Julie Wang, Muzammil Ali, Nana Rokutanda, Gordon Cohen, Do-Youn Oh
Journal: The Lancet Oncology (2024)
International Myeloma Working Group immunotherapy committee consensus guidelines and recommendations for optimal use of T-cell-engaging bispecific antibodies in multiple myeloma
Authors: Paula Rodriguez-Otero, Saad Usmani, Adam D Cohen, Niels W C J van de Donk, Xavier Leleu, Jaime Gállego Pérez-Larraya, Salomon Manier, Ajay K Nooka, Maria Victoria Mateos, Hermann Einsele, Monique Minnema, Michele Cavo, Benjamin A Derman, Noemi Puig, Francesca Gay, P Joy Ho, Wee-Joo Chng, Efstathios Kastritis, Gösta Gahrton, Katja Weisel, Chandramouli Nagarajan, Fredik Schjesvold, Joseph Mikhael, Luciano Costa, Noopur S Raje, Elena Zamagni, Roman Hájek, Niels Weinhold, Kwee Yong, Jing Christine Ye, Surbhi Sidhana, Giampaolo Merlini, Tom Martin, Yi Lin, Ajai Chari, Rakesh Popat, Jonathan L Kaufman
Journal: The Lancet Oncology (2024)
Trastuzumab deruxtecan versus treatment of physician's choice in patients with HER2-positive metastatic breast cancer (DESTINY-Breast02): patient-reported outcomes from a randomised, open-label, multicentre, phase 3 trial
Authors: Tanja Fehm, Francesco Cottone, Kyle Dunton, Fabrice André, Ian Krop, Yeon Hee Park, Michelino De Laurentiis, Yasuo Miyoshi, Anne Armstrong, Manuel Ruiz Borrego, Rinat Yerushalmi, Francois P Duhoux, Toshimi Takano, Wenjing Lu, Anton Egorov, Sung-Bae Kim
Journal: The Lancet Oncology (2024)

In DESTINY-Breast02, patients with HER2-positive unresectable or metastatic breast cancer who received trastuzumab deruxtecan demonstrated superior progression-free and overall survival compared with those receiving treatment of physician's choice. We present the patient-reported outcomes (PROs) and hospitalisation data.
Delphi consensus on stereotactic ablative radiotherapy for oligometastatic and oligoprogressive renal cell carcinoma—a European Society for Radiotherapy and Oncology study endorsed by the European Association of Urology
Authors: Giulia Marvaso, Barbara Alicja Jereczek-Fossa, Mattia Zaffaroni, Maria Giulia Vincini, Giulia Corrao, Nicolaus Andratschke, Ehsan H Balagamwala, Jens Bedke, Oliver Blanck, Umberto Capitanio, Rohann J M Correa, Gert De Meerleer, Ciro Franzese, Aurora Gaeta, Sara Gandini, Cristina Garibaldi, Peter C Gerszten, Silke Gillessen, William R Grubb, Matthias Guckenberger, Raquibul Hannan, Pavan M Jhaveri, Mirjana Josipovic, Linda G W Kerkmeijer, Eric J Lehrer, Magnus Lindskog, Alexander V Louie, Quynh-Nhu Nguyen, Piet Ost, David A Palma, Giuseppe Procopio, Maddalena Rossi, Michael Staehler, Alison C Tree, Yat Man Tsang, Nicholas Van As, Nicholas G Zaorsky, Thomas Zilli, David Pasquier, Shankar Siva
Journal: The Lancet Oncology (2024)
Curbing the climb in cancer incidence
Authors: None The Lancet Oncology
Journal: The Lancet Oncology (2024)

The Lancet's Breast Cancer Commission, published on April 15, 2024, predicts that by 2040, the global incidence of new cases of breast cancer will be more than 3 million per year, with the greatest rise in low-income and middle-income countries. Similarly, The Lancet's Commission on prostate cancer, published on April 4, 2024, forecasts the number of new cases of prostate cancer to increase annually worldwide from 1·4 million in 2020, to 2·9 million by 2040, and the number of deaths worldwide is predicted to rise from 375 000 in 2020, to almost 700 000 by 2040.
Traction-assisted endoscopic submucosal dissection to resect ileo-cecal valve neoplasia: a French retrospective multicenter case series
Authors: Clara Yzet, Timothee Wallenhorst, Jeremie Jacques, Mariana Figueiredo Ferreira, Jérôme Rivory, Florian Rostain, Louis Jean Masgnaux, Jean Grimaldi, Romain Legros, Pierre Lafeuille, Jérémie Albouys, Fabien Subtil, Marion Schaefer, Mathieu Pioche
Journal: Endoscopy (2024)

The ileocecal valve (ICV) is considered to be one of the most difficult locations for endoscopic submucosal dissection (ESD). The objective of this study was to evaluate the efficacy and safety of traction-assisted ESD in this situation.
Injectable and Dynamically Crosslinked Zwitterionic Hydrogels for Anti‐Fouling and Tissue Regeneration Applications
Authors: Zhicheng Pan, Jonathan Dorogin, Andrew Lofts, Gurpreet Randhawa, Fei Xu, Rebecca Slick, Mosana Abraha, Cecilia Tran, Michael Lawlor, Todd Hoare
Journal: Advanced Healthcare Materials (2024)

A zwitterionic injectable and degradable hydrogel based on hydrazide and aldehyde-functionalized [2-(methacryloyloxy)ethyl] dimethyl-(3-sulfopropyl)ammonium hydroxide (DMAPS) precursor polymers that can address practical in vivo needs is reported. Zwitterion fusion interactions between the zwitterionic precursor polymers create a secondary physically crosslinked network to enable much more rapid gelation than previously reported with other synthetic polymers, facilitating rapid gelation at much lower polymer concentrations or degrees of functionalization than previously accessible in addition to promoting zero swelling and long-term degradation responses and significantly stiffer mechanics than are typically accessed with previously reported low-viscosity precursor gelation systems. The hydrogels maintain the highly anti-fouling properties of conventional zwitterionic hydrogels against proteins, mammalian cells, and bacteria while also promoting anti-fibrotic tissue responses in vivo. Furthermore, the use of the hydrogels for effective delivery and subsequent controlled release of viable cells with tunable profiles both in vitro and in vivo is demonstrated, including the delivery of myoblasts in a mouse skeletal muscle defect model for reducing the time between injury and functional mobility recovery. The combination of the injectability, degradability, and tissue compatibility achieved offers the potential to expand the utility of zwitterionic hydrogels in minimally invasive therapeutic applications.
T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia
Authors: Philipp M. Roessner, Isabelle Seufert, Vicente Chapaprieta, Ruparoshni Jayabalan, Hannah Briesch, Ramon Massoni-Badosa, Pavle Boskovic, Julian Beckendorff, Tobias Roider, Lavinia Arseni, Mariana Coelho, Supriya Chakraborty, Alicia Vaca, Mariela Sivina, Markus Muckenhuber, Sonia Rodriguez-Rodriguez, Alice Bonato, Sophie A. Herbst, Marc Zapatka, Clare Sun, Helene Kretzmer, Thomas Naake, Peter-Martin Bruch, Felix Czernilofsky, Elisa ten Hacken, Martin Schneider, Dominic Helm, Deyan Yordanov Yosifov, Joseph Kauer, Alexey V. Danilov, Moritz Bewarder, Kristina Heyne, Christof Schneider, Stephan Stilgenbauer, Adrian Wiestner, Jan-Philipp Mallm, Jan A. Burger, Dimitar G Efremov, Peter Lichter, Sascha Dietrich, José Ignacio Martín-Subero, Karsten Rippe, Martina Seiffert
Journal: Blood (2024)
Placental circulating T cells: a novel, allogeneic CAR-T cell platform with preserved T-cell stemness, more favorable cytokine profile, and durable efficacy compared to adult PBMC-derived CAR-T
Authors: Natalia Ruggeri Barbaro, Theodore Drashansky, Kristina Tess, Mansour Djedaini, Robert Hariri, Shuyang He, William van der Touw, Kathy Karasiewicz
Journal: Journal for ImmunoTherapy of Cancer (2024)

Chimeric antigen receptor (CAR)-T cell quality and stemness are associated with responsiveness, durability, and memory formation, which benefit clinical responses. Autologous T cell starting material across patients with cancer is variable and CAR-T expansion or potency can fail during manufacture. Thus, strategies to develop allogeneic CAR-T platforms including the identification and expansion of T cell subpopulations that correspond with CAR-T potency are an active area of investigation. Here, we compared CAR-T cells generated from healthy adult peripheral blood T cells versus placental circulating T (P-T) cells.
Peripheral Oxygenation and Pulmonary Hemodynamics in Individuals With Fontan Circulation During 24-Hour High-Altitude Exposure Simulation
Authors: Nicole Müller, Julian Alexander Härtel, Jan Schmitz, Ute Baur, Melanie von der Wiesche, Iris Rieger, Darius Gerlach, Jon von Stritzky, Anja Bach, Christopher Hart, Janina Bros, Benedikt Seeger, Emily Zollmann, Marijke Grau, Boris Dragutinovic, Laura-Maria de Boni, Jan-Niklas Hönemann, Wilhelm Bloch, Daniel Aeschbach, Eva-Maria Elmenhorst, Ulrike Herberg, Alena Hess, Moritz Schumann, Tobias Kratz, Jens Jordan, Johannes Breuer, Jens Tank
Journal: Circulation (2024)
Will submucosal injection for colonic polyps get left out in the cold?
Authors: John J. Guardiola
Journal: Endoscopy (2024)

Cold snare resection is now recommended for adenomatous polyps <10 mm in size, and there is a growing body of evidence supporting its use for polyps larger than this [1] [2]. For sessile serrated lesions, cold snare resection has been repeatedly demonstrated to be successful, regardless of the lesion size, with or without submucosal injection, possibly owing to the ease of transection and the lack of submucosal fibrosis within sessile serrated lesions [3]. In this issue of Endoscopy, do Espirito Santo et al. report a systematic review and meta-analysis of 1556 patients from seven randomized controlled trials that compared cold snare resection versus cold snare endoscopic mucosal resection (C-EMR) using submucosal injection for colonic polyps and found there was no difference in the rates of complete resection, en bloc resection, and adverse events, although C-EMR did have a longer procedure time [4].
Endoscopic suture-based closure of a dehiscent rectal stump
Authors: Alanna Ebigbo, Julia Wanzl, Shimaa Afify, Sandra Nagl, Helmut Messmann
Journal: Endoscopy (2024)

Lower anterior rectal resection (LAR) with discontinuity resection is performed to avoid leakage of the colorectal anastomosis in high risk patients [1]. Unfortunately, rectal stump leakage can occur, and reoperation is associated with high morbidity and mortality. Endoscopic techniques, such as rinsing or vacuum-based therapy, have shown promising results in rectal leak management [2]. Recently, various endoscopic suture-based techniques have been introduced to facilitate gastrointestinal defect closure and leak or fistula management [3]. We describe the case of a 66-year-old man with rectal stump leakage, presenting to our unit 12 days after LAR and discontinuity resection. We opted for a two-step approach with initial suturing of the large post-surgical defect using the through-the-scope X-Tack Endoscopic HeliX Tacking System (Apollo Endosurgery, Austin, Texas, USA) ([Video 1]).
Alzheimer’s disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis
Authors: Lena Erkert, Reyes Gamez-Belmonte, Melanie Kabisch, Lena Schödel, Jay V Patankar, Miguel Gonzalez-Acera, Mousumi Mahapatro, Li-Li Bao, Christina Plattner, Anja A Kühl, Jie Shen, Lutgarde Serneels, Bart De Strooper, Markus F Neurath, Stefan Wirtz, Christoph Becker
Journal: Gut (2024)

Mutations in presenilin genes are the major cause of Alzheimer's disease. However, little is known about their expression and function in the gut. In this study, we identify the presenilins Psen1 and Psen2 as key molecules that maintain intestinal homoeostasis.
Identification and validation of anti-protein arginine methyltransferase 5 (PRMT5) antibody as a novel biomarker for systemic sclerosis (SSc)
Authors: Minrui Liang, Lingbiao Wang, Xiaolong Tian, Kun Wang, Xiaoyi Zhu, Linlin Huang, Qing Li, Wenjing Ye, Chen Chen, Haihua Yang, Wanqing Wu, Xiangjun Chen, Xiaoxia Zhu, Yu Xue, Weiguo Wan, Yanling Wu, Liwei Lu, Jiucun Wang, Hejian Zou, Tianlei Ying, Feng Zhou
Journal: Annals of the Rheumatic Diseases (2024)

In the complex panorama of autoimmune diseases, the characterisation of pivotal contributing autoantibodies that are involved in disease progression remains challenging. This study aimed to employ a global antibody profiling strategy to identify novel antibodies and investigate their association with systemic sclerosis (SSc).
Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer
Authors: Jad I. Belle, Devashish Sen, John M. Baer, Xiuting Liu, Varintra E. Lander, Jiayu Ye, Blake E. Sells, Brett L. Knolhoff, Ahmad Faiz, Liang-I Kang, Guhan Qian, Ryan C. Fields, Li Ding, Hyun Kim, Paolo P. Provenzano, Sheila A. Stewart, David G. DeNardo
Journal: Cancer Discovery (2024)

Pancreatic ductal adenocarcinoma (PDAC) therapeutic resistance is largely attributed to a unique tumor microenvironment embedded with an abundance of cancer-associated fibroblasts (CAF). Distinct CAF populations were recently identified, but the phenotypic drivers and specific impact of CAF heterogeneity remain unclear. In this study, we identify a subpopulation of senescent myofibroblastic CAFs (SenCAF) in mouse and human PDAC. These SenCAFs are a phenotypically distinct subset of myofibroblastic CAFs that localize near tumor ducts and accumulate with PDAC progression. To assess the impact of endogenous SenCAFs in PDAC, we used an LSL-KRASG12D;p53flox;p48-CRE;INK-ATTAC (KPPC-IA) mouse model of spontaneous PDAC with inducible senescent cell depletion. Depletion of senescent stromal cells in genetic and pharmacologic PDAC models relieved immune suppression by macrophages, delayed tumor progression, and increased responsiveness to chemotherapy. Collectively, our findings demonstrate that SenCAFs promote PDAC progression and immune cell dysfunction. Significance: CAF heterogeneity in PDAC remains poorly understood. In this study, we identify a novel subpopulation of senescent CAFs that promotes PDAC progression and immunosuppression. Targeting CAF senescence in combination therapies could increase tumor vulnerability to chemo or immunotherapy. See related article by Ye et al., p. 1302.
Assessment of biological organ age using molecular pathology in pre-transplant kidney biopsies
Authors: Roy Zhang, Patrick B. Trotter, James McCaffrey, Rory Fitzroy, Giorgio Trivioli, Benjamin J. Stewart, John R. Ferdinand, Kevin W. Loudon, Alexandra Riding, Jonathan West, Ashley Ferro, Menna R. Clatworthy
Journal: Kidney International (2024)

Organ shortage is a major challenge in kidney transplantation but the use of older donors, often with co-morbidities, is hampered by inconsistent outcomes. Methods of accurately stratifying marginal donor organs by clinical and histological assessment are lacking. To better understand organ variability, we profiled the transcriptomes of 271 kidneys from deceased donors at retrieval. Following correction for biopsy composition, we assessed molecular pathways that associated with delayed, and sub-optimal one-year graft function. Analysis of cortical biopsies identified an adaptive immune gene-rich module that significantly associated with increasing age and worse outcomes. Cellular deconvolution using human kidney reference single cell transcriptomes confirmed an increase in kidney-specific B and T cell signatures, as well as kidney macrophage, myofibroblast and fibroblast gene sets in this module. Surprisingly, innate immune pathway and neutrophil gene signature enrichment was associated with better outcomes. Thus, our work uncovers cellular molecular features of pathological organ ageing, identifiable at kidney retrieval, with translational potential.
Abdominal surgery in patients with chronic noncirrhotic extrahepatic portal vein obstruction: A multicenter retrospective study
Authors: Laure Elkrief, Corentin Denecheau-Girard, Marta Magaz, Michael Praktiknjo, Nicola Colucci, Isabelle Ollivier-Hourmand, Jérôme Dumortier, Macarena Simon Talero, Luis Tellez, Florent Artru, Magdalena Meszaros, Xavier Verhelst, Nicolas Tabchouri, Francisca Beires, Irene Andaluz, Massimo Leo, Mara Diekhöner, Safi Dokmak, Yliam Fundora, Judit Vidal-Gonzalez, Christian Toso, Aurélie Plessier, Juan Carlos Garcia Pagan, Pierre-Emmanuel Rautou
Journal: Hepatology (2024)

In patients with noncirrhotic chronic extrahepatic portal vein obstruction (EHPVO), data on the morbimortality of abdominal surgery are scarce.
Reply: Health warning for humble writers, distracted reviewers, and naive readers
Authors: Alena F. Ehrenbauer, Julius F.M. Egge, Benjamin Maasoumy, Karin Weissenborn
Journal: Hepatology (2024)

Ehrenbauer, Alena F.; Egge, Julius F. M.; Maasoumy, Benjamin; Weissenborn, Karin Author Information
Nanopore sequencing of influenza A and B in Oxfordshire and the United Kingdom, 2022–23
Authors: Jennifer Cane, Nicholas Sanderson, Sophie Barnett, Ali Vaughan, Megan Pott, Natalia Kapel, Marcus Morgan, Gerald Jesuthasan, Reggie Samuel, Muhammad Ehsaan, Hugh Boothe, Eric Haduli, Ruth Studley, Emma Rourke, Ian Diamond, Tom Fowler, Conall Watson, Nicole Stoesser, Ann Sarah Walker, Teresa Street, David W. Eyre
Journal: Journal of Infection (2024)

ObjectivesWe evaluated Nanopore sequencing for influenza surveillance.MethodsInfluenza A and B PCR-positive samples from hospital patients in Oxfordshire, UK, and a UK-wide population survey from winter 2022-23 underwent Nanopore sequencing following targeted rt-PCR amplification.ResultsFrom 941 infections, successful sequencing was achieved in 292/388(75%) available Oxfordshire samples: 231(79%) A/H3N2, 53(18%) A/H1N1, and 8(3%) B/Victoria and in 53/113(47%) UK-wide samples. Sequencing was more successful at lower Ct values. Most same-sample replicate sequences had identical haemagglutinin segments (124/141;88%); 36/39(92%) Illumina vs. Nanopore comparisons were identical, and 3(8%) differed by 1 variant.Comparison of Oxfordshire and UK-wide sequences showed frequent inter-regional transmission. Infections were closely-related to 2022-23 vaccine strains. Only one sample had a neuraminidase inhibitor resistance mutation.849/941(90%) Oxfordshire infections were community-acquired. 63/88(72%) potentially healthcare-associated cases shared a hospital ward with ≥1 known infectious case. 33 epidemiologically-plausible transmission links had sequencing data for both source and recipient: 8 were within ≤5 SNPs, of these, 5(63%) involved potential sources that were also hospital-acquired.ConclusionsNanopore influenza sequencing was reproducible and antiviral resistance rare. Inter-regional transmission was common; most infections were genomically similar. Hospital-acquired infections are likely an important source of nosocomial transmission and should be prioritised for infection prevention and control.